Model of carbon nanofiber internal structure formation and instability of catalytic growth interface

NASA Astrophysics Data System (ADS)

Merkulov, I. A.; Merkulov, V. I.; Melechko, A. V.; Klein, K. L.; Lowndes, D. H.; Simpson, M. L.

2007-07-01

It is well known that the internal structure determines the properties of carbon nanotubes and carbon nanofibers. However, a fundamental understanding of the processes that drive structure formation is missing, hindering the development of controlled synthesis strategies. Here we use theoretical calculations to explore the time evolution of the shape of the interface between the catalyst nanoparticle and its associated graphitic nanofiber at the initial stages of growth. This phenomenological description of the behavior of the catalyst nanoparticle-graphite interface constructed with model parameters provides new understanding of the mechanisms that control the internal structure of carbon nanofibers. We show that if the magnitude of the interface curvature exceeds a critical value κcrit , the interface loses stability and a cavity forms in the center of the nanofiber.

Internal rib structure can be predicted using mathematical models: An anatomic study comparing the chest to a shell dome with application to understanding fractures.

PubMed

Casha, Aaron R; Camilleri, Liberato; Manché, Alexander; Gatt, Ruben; Attard, Daphne; Gauci, Marilyn; Camilleri-Podesta, Marie-Therese; Mcdonald, Stuart; Grima, Joseph N

2015-11-01

The human rib cage resembles a masonry dome in shape. Masonry domes have a particular construction that mimics stress distribution. Rib cortical thickness and bone density were analyzed to determine whether the morphology of the rib cage is sufficiently similar to a shell dome for internal rib structure to be predicted mathematically. A finite element analysis (FEA) simulation was used to measure stresses on the internal and external surfaces of a chest-shaped dome. Inner and outer rib cortical thickness and bone density were measured in the mid-axillary lines of seven cadaveric rib cages using computerized tomography scanning. Paired t tests and Pearson correlation were used to relate cortical thickness and bone density to stress. FEA modeling showed that the stress was 82% higher on the internal than the external surface, with a gradual decrease in internal and external wall stresses from the base to the apex. The inner cortex was more radio-dense, P < 0.001, and thicker, P < 0.001, than the outer cortex. Inner cortical thickness was related to internal stress, r = 0.94, P < 0.001, inner cortical bone density to internal stress, r = 0.87, P = 0.003, and outer cortical thickness to external stress, r = 0.65, P = 0.035. Mathematical models were developed relating internal and external cortical thicknesses and bone densities to rib level. The internal anatomical features of ribs, including the inner and outer cortical thicknesses and bone densities, are similar to the stress distribution in dome-shaped structures modeled using FEA computer simulations of a thick-walled dome pressure vessel. Fixation of rib fractures should include the stronger internal cortex. © 2015 Wiley Periodicals, Inc.

Model Comparison of Nonlinear Structural Equation Models with Fixed Covariates.

ERIC Educational Resources Information Center

Lee, Sik-Yum; Song, Xin-Yuan

2003-01-01

Proposed a new nonlinear structural equation model with fixed covariates to deal with some complicated substantive theory and developed a Bayesian path sampling procedure for model comparison. Illustrated the approach with an illustrative example using data from an international study. (SLD)

The Sociocultural Adjustment Trajectory of International University Students and the Role of University Structures: A Qualitative Investigation

ERIC Educational Resources Information Center

Coles, Rebecca; Swami, Viren

2012-01-01

The present research explores the sociocultural adjustment of international students and the role played by university structures in the process. The adjustment process of international students has been modelled in psychological literature as a U-curve, a learning curve and most recently as a long, uneven and unending process of change. Yet,…

Effect of cementitious permanent formwork on moisture field of internal-cured concrete under drying

NASA Astrophysics Data System (ADS)

Wang, Jiahe; Zhang, Jun; Ding, Xiaoping; Zhang, Jiajia

2018-02-01

Drying shrinkage of concrete may still be the main source of cracking in concrete structures, even though the autogenous shrinkage of concrete can be effectively reduced by using internal curing. In the present paper, the effect of internal curing with pre-soaked lightweight aggregate and engineered cementitious composite permanent formwork (ECC-PF) on a moisture distribution in three kinds of concrete in a drying environment are investigated from both aspects of experiments and theoretical modeling. The test results show that the combination use of ECC-PF and internal curing can well maintain the humidity at a relatively high level not only at a place far from drying surface, but also at a place close to the drying surfaces. The developed model can well catch the characteristics of the moisture distribution in concrete under drying and the impacts of internal curing and ECC-PF can well be reflected as well. The model can be used for the design of concrete structures with combination use of internal curing and permanent formwork.

Internal structure of copper(II)-phthalocyanine thin films on SiO2/Si substrates investigated by grazing incidence x-ray reflectometry

NASA Astrophysics Data System (ADS)

Brieva, A. C.; Jenkins, T. E.; Jones, D. G.; Strössner, F.; Evans, D. A.; Clark, G. F.

2006-04-01

The internal structure of copper(II)-phthalocyanine (CuPc) thin films grown on SiO2/Si by organic molecular beam deposition has been studied by grazing incidence x-ray reflectometry (GIXR) and atomic force microscopy. The electronic density profile is consistent with a structure formed by successive monolayers of molecules in the α form with the b axis lying in the substrate surface plane. The authors present an electronic density profile model of CuPc films grown on SiO2/Si. The excellent agreement between the model and experimental data allows postdeposition monitoring of the internal structure of the CuPc films with the nondestructive GIXR technique, providing a tool for accurate control of CuPc growth on silicon-based substrates. In addition, since the experiments have been carried out ex situ, they show that these structures can endure ambient conditions.

Validation of the internalization of the Model Minority Myth Measure (IM-4) and its link to academic performance and psychological adjustment among Asian American adolescents.

PubMed

Yoo, Hyung Chol; Miller, Matthew J; Yip, Pansy

2015-04-01

There is limited research examining psychological correlates of a uniquely racialized experience of the model minority stereotype faced by Asian Americans. The present study examined the factor structure and fit of the only published measure of the internalization of the model minority myth, the Internalization of the Model Minority Myth Measure (IM-4; Yoo et al., 2010), with a sample of 155 Asian American high school adolescents. We also examined the link between internalization of the model minority myth types (i.e., myth associated with achievement and myth associated with unrestricted mobility) and psychological adjustment (i.e., affective distress, somatic distress, performance difficulty, academic expectations stress), and the potential moderating effect of academic performance (cumulative grade point average). Results suggested the 2-factor model of the IM-4 had an acceptable fit to the data and supported the factor structure using confirmatory factor analyses. Internalizing the model minority myth of achievement related positively to academic expectations stress; however, internalizing the model minority myth of unrestricted mobility related negatively to academic expectations stress, both controlling for gender and academic performance. Finally, academic performance moderated the model minority myth associated with unrestricted mobility and affective distress link and the model minority myth associated with achievement and performance difficulty link. These findings highlight the complex ways in which the model minority myth relates to psychological outcomes. (c) 2015 APA, all rights reserved).

Internalized Heterosexism among HIV-Positive, Gay-Identified Men: Implications for HIV Prevention and Care

ERIC Educational Resources Information Center

Johnson, Mallory O.; Carrico, Adam W.; Chesney, Margaret A.; Morin, Stephen F.

2008-01-01

Internalized heterosexism (IH), or the internalization of societal antihomosexual attitudes, has been consistently linked to depression and low self-esteem among gay men, and it has been inconclusively associated with substance use and sexual risk in gay and bisexual men. Using structural equation modeling, the authors tested a model framed in…

An economic model of international wood supply, forest stock and forest area change

Treesearch

James A. Turner; Joseph Buongiorno; Shushuai Zhu

2006-01-01

Wood supply, the link between roundwood removals and forest resources, is an important component of forest sector models. This paper develops a model of international wood supply within the structure of the spatial equilibrium Global Forest Products Model. The wood supply model determines, for each country, the annual forest harvest, the annual change of forest stock...

Robust permanence for ecological equations with internal and external feedbacks.

PubMed

Patel, Swati; Schreiber, Sebastian J

2018-07-01

Species experience both internal feedbacks with endogenous factors such as trait evolution and external feedbacks with exogenous factors such as weather. These feedbacks can play an important role in determining whether populations persist or communities of species coexist. To provide a general mathematical framework for studying these effects, we develop a theorem for coexistence for ecological models accounting for internal and external feedbacks. Specifically, we use average Lyapunov functions and Morse decompositions to develop sufficient and necessary conditions for robust permanence, a form of coexistence robust to large perturbations of the population densities and small structural perturbations of the models. We illustrate how our results can be applied to verify permanence in non-autonomous models, structured population models, including those with frequency-dependent feedbacks, and models of eco-evolutionary dynamics. In these applications, we discuss how our results relate to previous results for models with particular types of feedbacks.

A drug procurement, storage and distribution model in public hospitals in a developing country.

PubMed

Kjos, Andrea L; Binh, Nguyen Thanh; Robertson, Caitlin; Rovers, John

2016-01-01

There is growing interest in pharmaceutical supply chains and distribution of medications at national and international levels. Issues of access and efficiency have been called into question. However, evaluations of system outcomes are not possible unless there are contextual data to describe the systems in question. Available guidelines provided by international advisory bodies such as the World Health Organization and the International Pharmacy Federation may be useful for developing countries like Vietnam when seeking to describe the pharmaceutical system. The purpose of this study was to describe a conceptual model for drug procurement, storage, and distribution in four government-owned hospitals in Vietnam. This study was qualitative and used semi-structured interviews with key informants from within the Vietnamese pharmaceutical system. Translated transcriptions were used to conduct a content analysis of the data. A conceptual model for the Vietnamese pharmaceutical system was described using structural and functional components. This model showed that in Vietnam, governmental policy influences the structural framework of the system, but allows for flexibility at the functional level of practice. Further, this model can be strongly differentiated from the models described by international advisory bodies. This study demonstrates a method for health care systems to describe their own models of drug distribution to address quality assurance, systems design and benchmarking for quality improvement. Copyright © 2016 Elsevier Inc. All rights reserved.

Structure and functions of internal working models of attachment and their role for emotion regulation.

PubMed

Zimmermann, P

1999-12-01

The concept of organization in the service of adaptation has been applied to attachment theory (Sroufe & Waters, 1977) as well as to a variety of life sciences (Ryan, Kuhi & Deci, 1997). Internal working models (IWMs) are postulated as providing organizing structure to the attachment behavior system controlling attachment behaviors toward caregivers and, with increasing age, autonomous individual adaptation. While many theoretical specifications have been suggested on that topic (e.g. Bretherton, 1987, 1990; Bretherton & Munholland, 1999; Main, Kaplan & Cassidy, 1985; Sroufe & Fleeson, 1986), empirical studies focusing directly on the structure or functions of internal working models are rare. Knowledge about the structure and functioning of IWMs could add to the understanding of the developmental influences of the attachment organization across the life-span. In this paper two topics will be addressed shortly and related to an empirical investigation concerning the relationship between attachment representations during late adolescence and emotion regulation patterns: (1) structure and functions of IWMs in terms of information-processing and emotion and behavior regulation; and (2) the transfer from IWMs of self-with-attachment figures to adaptive personality structures based on autonomous self-regulation.

Numerical investigations of internal stresses on carbon steel based on ultrasonic LCR waves

NASA Astrophysics Data System (ADS)

Ramasamy, R.; Ibrahim, Z.; Chai, H. K.

2017-10-01

Internal stresses or residual stresses in the structural elements are very crucial in carrying out in-service evaluations and fitness-for-purpose assessments. The generation of these internal stresses can occur as result of the fabrication of the steel members, installation sequence or other ad-hoc events such as accidents or impact. The accurate prediction of the internal stresses will contribute towards estimating the integrity state of the structural elements, with respect to their material allowable stresses. This paper investigates the explicit FE based numerical modelling of the ultrasonic based non-destructive technique, utilising the measurable longitudinal critical refracted wave (LCR) and relating these to the internal stresses within the structural elements by the evaluation of the material dependent acoustoelastic factors. The subsurface travel path of the LCR wave inside the structural elements makes it a sub-surface stress measurement technique and the linearised relationship with corresponding internal stresses can be systematically applied repeatedly. The numerical results are compared against laboratory tests data to correlate the findings and to establish modelling feasibility for future proof-of-concepts. It can be concluded from this numerical investigation, that the subsurface ultrasonic LCR wave has great potential to be implemented for in-situ structural residual stress measurements, as compared to other available surface measurements such as strain gauges or x-ray diffraction.

International Postgraduate Students' Cross-Cultural Adaptation in Malaysia: Antecedents and Outcomes

ERIC Educational Resources Information Center

Shafaei, Azadeh; Razak, Nordin Abd

2016-01-01

This study develops and empirically tests a conceptual model capturing the factors impacting students' cross-cultural adaptation and the outcomes resulting from such adaption. Data were obtained from a sample of international postgraduate students from six Malaysian public universities using a structured questionnaire. Structural equation…

Consolidating Orientation of Pedagogic Functions of University Teachers in International Students Training

ERIC Educational Resources Information Center

Dzhamalova, Bika B.; Timonin, Andrey I.; Kolesov, Vladimir I.; Pavlov, Vladimir V.; Evstegneeva, Anastasiia A.

2016-01-01

This article is focused on the development of the structure and content of consolidating orientation of pedagogical functions of university teachers in international students' training. The leading method of research is the modeling method that allows producing of the established structure's and content's justification of consolidating orientation…

Modeling a flexible representation machinery of human concept learning.

PubMed

Matsuka, Toshihiko; Sakamoto, Yasuaki; Chouchourelou, Arieta

2008-01-01

It is widely acknowledged that categorically organized abstract knowledge plays a significant role in high-order human cognition. Yet, there are many unknown issues about the nature of how categories are internally represented in our mind. Traditionally, it has been considered that there is a single innate internal representation system for categorical knowledge, such as Exemplars, Prototypes, or Rules. However, results of recent empirical and computational studies collectively suggest that the human internal representation system is apparently capable of exhibiting behaviors consistent with various types of internal representation schemes. We, then, hypothesized that humans' representational system as a dynamic mechanism, capable of selecting a representation scheme that meets situational characteristics, including complexities of category structure. The present paper introduces a framework for a cognitive model that integrates robust and flexible internal representation machinery. Three simulation studies were conducted. The results showed that SUPERSET, our new model, successfully exhibited cognitive behaviors that are consistent with three main theories of the human internal representation system. Furthermore, a simulation study on social cognitive behaviors showed that the model was capable of acquiring knowledge with high commonality, even for a category structure with numerous valid conceptualizations.

Heat up and failure of BWR upper internals during a severe accident

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robb, Kevin R.

In boiling water reactors, the shroud dome, separators, and dryers above the core are made of approximately 100,000 kg of stainless steel. During a severe accident in which the coolant boils away and exothermic oxidation of zirconium occurs, gases (steam and hydrogen) are superheated in the core region and pass through the upper internals. In this scenario, the upper internals can also be heated by thermal radiation from the hot degrading core. Historically, models of the upper internals have been relatively simple in severe accident codes. The upper internals are typically modeled in MELCOR as two lumped volumes with simplifiedmore » heat transfer characteristics and no structural integrity considerations, and with limited ability to oxidize, melt, and relocate. The potential for and the subsequent impact of the upper internals to heat up, oxidize, fail, and relocate during a severe accident was investigated. A higher fidelity representation of the shroud dome, steam separators, and steam driers was developed in MELCOR v1.8.6 by extending the core region upwards. The MELCOR modeling effort entailed adding 45 additional core cells and control volumes, 98 flow paths, and numerous control functions. The model accounts for the mechanical loading and structural integrity, oxidation, melting, flow area blockage, and relocation of the various components. Consistent with a previous study, the results indicate that the upper internals can reach high temperatures during a severe accident sufficient to lose their structural integrity and relocate. Finally, the additional 100 metric tons of stainless steel debris influences the subsequent in-vessel and ex-vessel accident progression.« less

Heat up and failure of BWR upper internals during a severe accident

DOE PAGES

Robb, Kevin R.

2017-02-21

In boiling water reactors, the shroud dome, separators, and dryers above the core are made of approximately 100,000 kg of stainless steel. During a severe accident in which the coolant boils away and exothermic oxidation of zirconium occurs, gases (steam and hydrogen) are superheated in the core region and pass through the upper internals. In this scenario, the upper internals can also be heated by thermal radiation from the hot degrading core. Historically, models of the upper internals have been relatively simple in severe accident codes. The upper internals are typically modeled in MELCOR as two lumped volumes with simplifiedmore » heat transfer characteristics and no structural integrity considerations, and with limited ability to oxidize, melt, and relocate. The potential for and the subsequent impact of the upper internals to heat up, oxidize, fail, and relocate during a severe accident was investigated. A higher fidelity representation of the shroud dome, steam separators, and steam driers was developed in MELCOR v1.8.6 by extending the core region upwards. The MELCOR modeling effort entailed adding 45 additional core cells and control volumes, 98 flow paths, and numerous control functions. The model accounts for the mechanical loading and structural integrity, oxidation, melting, flow area blockage, and relocation of the various components. Consistent with a previous study, the results indicate that the upper internals can reach high temperatures during a severe accident sufficient to lose their structural integrity and relocate. Finally, the additional 100 metric tons of stainless steel debris influences the subsequent in-vessel and ex-vessel accident progression.« less

A Componential IRT Model for Guilt.

ERIC Educational Resources Information Center

Smits, Dirk J. M.; De Boeck, Paul

2003-01-01

Studied the process structure of guilt with an adaptation of the Model with Internal Restrictions on Item Difficulty (R. Butter and others, 1998) administered to 270 high school students. Findings show that this kind of modeling is appropriate to investigate the structure of other emotions. (SLD)

International Energy Module - NEMS Documentation

EIA Publications

2014-01-01

Summarizes the overall structure of the International Energy Model and its interface with other NEMS modules, mathematical specifications of behavioral relationships, and data sources and estimation methods.

Heat up and potential failure of BWR upper internals during a severe accident

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robb, Kevin R

2015-01-01

In boiling water reactors, the steam dome, steam separators, and dryers above the core are comprised of approximately 100 tons of stainless steel. During a severe accident in which the coolant boils away and exothermic oxidation of zirconium occurs, gases (steam and hydrogen) are superheated in the core region and pass through the upper internals. Historically, the upper internals have been modeled using severe accident codes with relatively simple approximations. The upper internals are typically modeled in MELCOR as two lumped volumes with simplified heat transfer characteristics, with no structural integrity considerations, and with limited ability to oxidize, melt, andmore » relocate. The potential for and the subsequent impact of the upper internals to heat up, oxidize, fail, and relocate during a severe accident was investigated. A higher fidelity representation of the shroud dome, steam separators, and steam driers was developed in MELCOR v1.8.6 by extending the core region upwards. This modeling effort entailed adding 45 additional core cells and control volumes, 98 flow paths, and numerous control functions. The model accounts for the mechanical loading and structural integrity, oxidation, melting, flow area blockage, and relocation of the various components. The results indicate that the upper internals can reach high temperatures during a severe accident; they are predicted to reach a high enough temperature such that they lose their structural integrity and relocate. The additional 100 tons of stainless steel debris influences the subsequent in-vessel and ex-vessel accident progression.« less

Structural response of 1/20-scale models of the Clinch River Breeder Reactor to a simulated hypothetical core-disruptive accident

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romander, C M; Cagliostro, D J

Five experiments were performed to help evaluate the structural integrity of the reactor vessel and head design and to verify code predictions. In the first experiment (SM 1), a detailed model of the head was loaded statically to determine its stiffness. In the remaining four experiments (SM 2 to SM 5), models of the vessel and head were loaded dynamically under a simulated 661 MW-s hypothetical core disruptive accident (HCDA). Models SM 2 to SM 4, each of increasing complexity, systematically showed the effects of upper internals structures, a thermal liner, core support platform, and torospherical bottom on vessel response.more » Model SM 5, identical to SM 4 but more heavily instrumented, demonstrated experimental reproducibility and provided more comprehensive data. The models consisted of a Ni 200 vessel and core barrel, a head with shielding and simulated component masses, and an upper internals structure (UIS).« less

Two radars for AIM mission: A direct observation of the asteroid's structure from deep interior to regolith

NASA Astrophysics Data System (ADS)

Herique, A.; Ciarletti, V.

2015-10-01

Our knowledge of the internal structure of asteroids is, so far, indirect - relying entirely on inferences from remote sensing observations of the surface, and theoretical modeling. What are the bulk properties of the regolith and deep interior? And what are the physical processes that shape their internal structures? Direct measurements are needed to provide answers that will directly improve our ability to understand and model the mechanisms driving Near Earth Asteroids (NEA) for the benefit of science as well as for planetary defense or exploration. Radar tomography is the only technique to characterize internal structure from decimetric scale to global scale. This paper reviews the benefits of direct measurement of the asteroid interior. Then the radar concepts for both deep interior and shallow subsurface are presented and the radar payload proposed for the AIDA/AIM mission is outlined.

Why the Major Field Test in Business Does Not Report Subscores: Reliability and Construct Validity Evidence. Research Report. ETS RR-12-11

ERIC Educational Resources Information Center

Ling, Guangming

2012-01-01

To assess the value of individual students' subscores on the Major Field Test in Business (MFT Business), I examined the test's internal structure with factor analysis and structural equation model methods, and analyzed the subscore reliabilities using the augmented scores method. Analyses of the internal structure suggested that the MFT Business…

Numerical Modeling of Internal Flow Aerodynamics. Part 2: Unsteady Flows

DTIC Science & Technology

2004-01-01

fluid- structure coupling, ...). • • • • • Prediction: in this simulation, we want to assess the effect of a change in SRM geometry, propellant...surface reaches the structure ). The third characteristic time describes the slow evolution of the internal geometry. The last characteristic time...incorporates fluid- structure coupling facility, and is parallel. MOPTI® manages exchanges between two principal computational modules: • • A varying

The Structure of Personality Disorders in Individuals with Posttraumatic Stress Disorder

PubMed Central

Wolf, Erika J.; Miller, Mark W.; Brown, Timothy A.

2015-01-01

Research on the structure of personality disorders (PDs) has relied primarily on exploratory analyses to evaluate trait-based models of the factors underlying the covariation of these disorders. This study used confirmatory factor analysis to evaluate whether a model that included both PD traits and a general personality dysfunction factor would account for the comorbidity of the PDs better than a trait-only model. It also examined if the internalizing/externalizing model of psychopathology, developed previously through research on the structure of Axis I disorders, might similarly account for the covariation of the Axis II disorders in a sample of 245 veterans and non-veterans with posttraumatic stress disorder. Results indicated that the best fitting model was a modified bifactor structure composed of nine lower-order common factors. These factors indexed pathology ranging from aggression to dependency, with the correlations among them accounted for by higher-order Internalizing and Externalizing factors. Further, a general factor, reflecting a construct that we termed boundary disturbance, accounted for additional variance and covariance across nearly all the indicators. The Internalizing, Externalizing, and Boundary Disturbance factors evidenced differential associations with trauma-related covariates. These findings suggest continuity in the underlying structure of psychopathology across DSM-IV Axes I & II and provide empirical evidence of a pervasive, core disturbance in the boundary between self and other across the PDs. PMID:22448802

Understanding comorbidity among internalizing problems: Integrating latent structural models of psychopathology and risk mechanisms

PubMed Central

Hankin, Benjamin L.; Snyder, Hannah R.; Gulley, Lauren D.; Schweizer, Tina H.; Bijttebier, Patricia; Nelis, Sabine; Toh, Gim; Vasey, Michael W.

2016-01-01

It is well known that comorbidity is the rule, not the exception, for categorically defined psychiatric disorders, and this is also the case for internalizing disorders of depression and anxiety. This theoretical review paper addresses the ubiquity of comorbidity among internalizing disorders. Our central thesis is that progress in understanding this co-occurrence can be made by employing latent dimensional structural models that organize both psychopathology as well as vulnerabilities and risk mechanisms and by connecting the multiple levels of risk and psychopathology outcomes together. Different vulnerabilities and risk mechanisms are hypothesized to predict different levels of the structural model of psychopathology. We review the present state of knowledge based on concurrent and developmental sequential comorbidity patterns among common discrete psychiatric disorders in youth, and then we advocate for the use of more recent bifactor dimensional models of psychopathology (e.g., p factor, Caspi et al., 2014) that can help to explain the co-occurrence among internalizing symptoms. In support of this relatively novel conceptual perspective, we review six exemplar vulnerabilities and risk mechanisms, including executive function, information processing biases, cognitive vulnerabilities, positive and negative affectivity aspects of temperament, and autonomic dysregulation, along with the developmental occurrence of stressors in different domains, to show how these vulnerabilities can predict the general latent psychopathology factor, a unique latent internalizing dimension, as well as specific symptom syndrome manifestations. PMID:27739389

Modeling the Internal Structure of Mars Using Normal Mode Relaxation Theory

NASA Astrophysics Data System (ADS)

Pithawala, T. M.; Ghent, R. R.; Bills, B. G.

2010-12-01

We seek to resolve an apparent paradox between two sets of observations, which seem to suggest quite different thermal structures for the deep interior of Mars. The orbit of Phobos is observed to be accelerating along-track at a rate of (273.4 ± 1.2) 10^(-5) deg/yr^(2), which implies that the orbit is shrinking at (4.03 ± 0.03) cm/yr, and losing energy at a rate of 3.4 MW. The most likely sink for that energy is tidal dissipation within Mars, seemingly requiring a warm interior. However, static support of the gravity and topography of Mars requires a thick elastic lithosphere, indicating a relatively cool (and therefore stiff) mantle. Using normal mode relaxation theory we model the internal viscosity structure of Mars by analyzing its response to tidal forcing from Phobos. We investigate spherical axisymmetric layered viscoelastic models, seeking to satisfy what is known about planetary differentiation, to support large-scale topography via a thick elastic lithosphere, and to yield the observed tidal dissipation rate. We present a family of 4-layer models (core, mantle, lithosphere, and thin weak layer) that satisfy these constraints, and discuss the implications for Mars’ internal structure.

The supramolecular structure of bone: X-ray scattering analysis and lateral structure modeling

PubMed Central

Zhou, Hong-Wen; Burger, Christian; Wang, Hao; Hsiao, Benjamin S.; Chu, Benjamin; Graham, Lila

2016-01-01

The evolution of vertebrates required a key development in supramolecular evolution: internally mineralized collagen fibrils. In bone, collagen molecules and mineral crystals form a nanocomposite material comparable to cast iron in tensile strength, but several times lighter and more flexible. Current understanding of the internal nanoscale structure of collagen fibrils, derived from studies of rat tail tendon (RTT), does not explain how nucleation and growth of mineral crystals can occur inside a collagen fibril. Experimental obstacles encountered in studying bone have prevented a solution to this problem for several decades. This report presents a lateral packing model for collagen molecules in bone fibrils, based on the unprecedented observation of multiple resolved equatorial reflections for bone tissue using synchrotron small-angle X-ray scattering (SAXS; ∼1 nm resolution). The deduced structure for pre-mineralized bone fibrils includes features that are not present in RTT: spatially discrete microfibrils. The data are consistent with bone microfibrils similar to pentagonal Smith microfibrils, but are not consistent with the (nondiscrete) quasi-hexagonal microfibrils reported for RTT. These results indicate that collagen fibrils in bone and tendon differ in their internal structure in a manner that allows bone fibrils, but not tendon fibrils, to internally mineralize. In addition, the unique pattern of collagen cross-link types and quantities in mineralized tissues can be can be accounted for, in structural/functional terms, based on a discrete microfibril model. PMID:27599731

Structural testing and analysis of a braided, inflatable fabric torus structure

NASA Astrophysics Data System (ADS)

Young, Andrew C.; Davids, William G.; Whitney, Daniel J.; Clapp, Joshua D.; Goupee, Andrew J.

2017-10-01

Inflatable structural members have military, disaster relief, aerospace and other important applications as they possess low mass, can be stored in a relatively small volume and have significant load-carrying capacity once pressurized. Of particular interest to the present research is the Hypersonic Inflatable Aerodynamic Decelerator (HIAD) structure under development by NASA. In order to make predictions about the structural response of the HIAD system, it is necessary to understand the response of individual inflatable tori composing the HIAD structure. These inflatable members present unique challenges to structural testing and modeling due to their internal inflation pressure and relative compliance. Structural testing was performed on a braided, inflatable, toroidal structural member with axial reinforcing cords. The internal inflation pressure, magnitude of enforced displacement and loading methodology were varied. In-plane and out-of-plane experimental results were compared to model predictions using a three dimensional, corotational, flexibility-based fiber-beam finite element model including geometric and material nonlinearities, as well as the effects of inflation pressure. It was found that in order to approximate the load-deformation response observed in experimentation it is necessary to carefully control the test and model boundary conditions and loading scheme.

Multiple-Instance Regression with Structured Data

NASA Technical Reports Server (NTRS)

Wagstaff, Kiri L.; Lane, Terran; Roper, Alex

2008-01-01

We present a multiple-instance regression algorithm that models internal bag structure to identify the items most relevant to the bag labels. Multiple-instance regression (MIR) operates on a set of bags with real-valued labels, each containing a set of unlabeled items, in which the relevance of each item to its bag label is unknown. The goal is to predict the labels of new bags from their contents. Unlike previous MIR methods, MI-ClusterRegress can operate on bags that are structured in that they contain items drawn from a number of distinct (but unknown) distributions. MI-ClusterRegress simultaneously learns a model of the bag's internal structure, the relevance of each item, and a regression model that accurately predicts labels for new bags. We evaluated this approach on the challenging MIR problem of crop yield prediction from remote sensing data. MI-ClusterRegress provided predictions that were more accurate than those obtained with non-multiple-instance approaches or MIR methods that do not model the bag structure.

The Impact of Internal Wave Seasonality on the Continental Shelf Energy Budget

NASA Astrophysics Data System (ADS)

Wihsgott, Juliane U.; Sharples, Jonathan; Hopkins, Joanne; Palmer, Matthew R.; Mattias Green, J. A.

2017-04-01

Heating-stirring models are widely used to simulate the timing and strength of stratification in continental shelf environments. Such models are based on bulk potential energy (PE) budgets: the loss of PE due to thermal stratification is balanced by wind and tidal mixing. The model often fails to accurately predict the observed vertical structure, as it only considers forces acting on the surface and bottom boundary of the water column. This highlights the need for additional internal energy sources to close this budget, and produce an accurate seasonal cycle of stratification. We present new results that test the impact of boundary layer and internal wave forcing on stratification and vertical density structure in continental shelves. A new series of continuous measurements of full water depth vertical structure, dynamics and meteorological data spanning 17 months (March'14-July'15) provide unprecedented coverage over a full seasonal cycle at a station 120 km north-east from the continental shelf break. We observe a highly variable but energetic internal wave field from the onset of stratification that suggests a continuous supply of internal PE. The heating-stirring model reproduces bulk characteristics of the seasonal cycle. While it accurately predicts the timing of the onset in spring and peak stratification in late summer there is a persistent 20 J m-3 positive offset between the model and observations throughout this period. By including a source of internal energy in the model we improve the prediction for the strength of stratification and the vertical distribution of heat. Yet a constant source of PE seems to result in a seasonal discrepancy resulting in too little mixing during strong stratification and too much mixing during transient periods. The discrepancy seen in the model is consistent with the seasonality observed in the internal wave field. We will establish the role that changing stratification (N2) exerts on the internal wave field and vice versa. Ultimately, we will demonstrate how the strength and vertical range of shear varies seasonally and what effect it has on supplying PE to midwater mixing.

Studies on muon tomography for archaeological internal structures scanning

NASA Astrophysics Data System (ADS)

Gómez, H.; Carloganu, C.; Gibert, D.; Jacquemier, J.; Karyotakis, Y.; Marteau, J.; Niess, V.; Katsanevas, S.; Tonazzo, A.

2016-05-01

Muon tomography is a potential non-invasive technique for internal structure scanning. It has already interesting applications in geophysics and can be used for archaeological purposes. Muon tomography is based on the measurement of the muon flux after crossing the structure studied. Differences on the mean density of these structures imply differences on the detected muon rate for a given direction. Based on this principle, Monte Carlo simulations represent a useful tool to provide a model of the expected muon rate and angular distribution depending on the composition of the studied object, being useful to estimate the expected detected muons and to better understand the experimental results. These simulations are mainly dependent on the geometry and composition of the studied object and on the modelling of the initial muon flux at surface. In this work, the potential of muon tomography in archaeology is presented and evaluated with Monte Carlo simulations by estimating the differences on the muon rate due to the presence of internal structures and its composition. The influence of the chosen muon model at surface in terms of energy and angular distributions in the final result has been also studied.

The Concept of Adjustment: A Structural Model.

ERIC Educational Resources Information Center

Dodds, A.; And Others

1994-01-01

This study analyzed scores of 469 British adult clients with recent loss of sight on the Nottingham Adjustment Scale using LISREL structural modeling techniques. Results supported a theoretical model of the self in terms of two latent factors--internal self-worth and self as agent. Implications for rehabilitation and intervention with cognitive…

Determination of Elevator and Rudder Hinge Forces on the Learjet Model 55 Aircraft

NASA Technical Reports Server (NTRS)

Boroughs, R. R.; Padmanabhan, V.

1983-01-01

The empennage structure on the Learjet 55 aircraft was quite similar to the empennage structure on earlier Learjet models. However, due to an important structural change in the vertical fin along with the new loads environment on the 50 series aircraft, a structural test was required on the vertical fin, but the horizontal tail was substantiated by a comparative analysis with previous tests. NASTRAN analysis was used to investigate empennage deflections, stress levels, and control surface hinge forces. The hinge force calculations were made with the control surfaces in the deflected as well as undeflected configurations. A skin panel buckling analysis was also performed, and the non-linear effects of buckling were simulated in the NASTRAN model to more accurately define internal loads and stress levels. Comparisons were then made between the Model 55 and the Model 35/36 stresses and internal forces to determine which components were qualified by previous tests. Some of the methods and techniques used in this analysis are described.

Structural response of 1/20-scale models of the Clinch River Breeder Reactor to a simulated hypothetical core disruptive accident. Technical report 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romander, C. M.; Cagliostro, D. J.

Five experiments were performed to help evaluate the structural integrity of the reactor vessel and head design and to verify code predictions. In the first experiment (SM 1), a detailed model of the head was loaded statically to determine its stiffness. In the remaining four experiments (SM 2 to SM 5), models of the vessel and head were loaded dynamically under a simulated 661 MW-sec hypothetical core disruptive accident (HCDA). Models SM 2 to SM 4, each of increasing complexity, systematically showed the effects of upper internals structures, a thermal liner, core support platform, and torospherical bottom on vessel response.more » Model SM 5, identical to SM 4 but more heavily instrumented, demonstrated experimental reproducibility and provided more comprehensive data. The models consisted of a Ni 200 vessel and core barrel, a head with shielding and simulated component masses, an upper internals structure (UIS), and, in the more complex models SM 4 and SM 5, a Ni 200 thermal liner and core support structure. Water simulated the liquid sodium coolant and a low-density explosive simulated the HCDA loads.« less

Modeling ready biodegradability of fragrance materials.

PubMed

Ceriani, Lidia; Papa, Ester; Kovarich, Simona; Boethling, Robert; Gramatica, Paola

2015-06-01

In the present study, quantitative structure activity relationships were developed for predicting ready biodegradability of approximately 200 heterogeneous fragrance materials. Two classification methods, classification and regression tree (CART) and k-nearest neighbors (kNN), were applied to perform the modeling. The models were validated with multiple external prediction sets, and the structural applicability domain was verified by the leverage approach. The best models had good sensitivity (internal ≥80%; external ≥68%), specificity (internal ≥80%; external 73%), and overall accuracy (≥75%). Results from the comparison with BIOWIN global models, based on group contribution method, show that specific models developed in the present study perform better in prediction than BIOWIN6, in particular for the correct classification of not readily biodegradable fragrance materials. © 2015 SETAC.

Factorial and Structural Validity of Holland's Hexagonal Model for an Asian Student Population.

ERIC Educational Resources Information Center

Tay, Kenneth Kim; Hill, Joseph A.; Ward, Connie M.

A study examined the utility of Holland's hexagonal model as a culturally appropriate theoretical framework for U.S. career psychologists working with Asian international students. Chinese-descent international students enrolled in three Southeastern universities (n=170) completed three instruments: Holland's Self-Directed Search (SDS), an…

Validation of the Spanish version of Mackey childbirth satisfaction rating scale.

PubMed

Caballero, Pablo; Delgado-García, Beatriz E; Orts-Cortes, Isabel; Moncho, Joaquin; Pereyra-Zamora, Pamela; Nolasco, Andreu

2016-04-16

The "Mackey Childbirth Satisfaction Rating Scale" (MCSRS) is a complete non-validated scale which includes the most important factors associated with maternal satisfaction. Our primary purpose was to describe the internal structure of the scale and validate the reliability and validity of concept of its Spanish version MCSRS-E. The MCSRS was translated into Spanish, back-translated and adapted to the Spanish population. It was then administered following a pilot test with women who met the study participant requirements. The scale structure was obtained by performing an exploratory factorial analysis using a sample of 304 women. The structures obtained were tested by conducting a confirmatory factorial analysis using a sample of 159 women. To test the validity of concept, the structure factors were correlated with expectations prior to childbirth experiences. McDonald's omegas were calculated for each model to establish the reliability of each factor. The study was carried out at four University Hospitals; Alicante, Elche, Torrevieja and Vinalopo Salud of Elche. The inclusion criteria were women aged 18-45 years old who had just delivered a singleton live baby at 38-42 weeks through vaginal delivery. Women who had difficulty speaking and understanding Spanish were excluded. The process generated 5 different possible internal structures in a nested model more consistent with the theory than other internal structures of the MCSRS applied hitherto. All of them had good levels of validation and reliability. This nested model to explain internal structure of MCSRS-E can accommodate different clinical practice scenarios better than the other structures applied to date, and it is a flexible tool which can be used to identify the aspects that should be changed to improve maternal satisfaction and hence maternal health.

Relevance of Internal Friction and Structural Constraints for the Dynamics of Denatured Bovine Serum Albumin.

PubMed

Ameseder, Felix; Radulescu, Aurel; Holderer, Olaf; Falus, Peter; Richter, Dieter; Stadler, Andreas M

2018-05-17

A general property of disordered proteins is their structural expansion that results in a high molecular flexibility. The structure and dynamics of bovine serum albumin (BSA) denatured by guanidinium hydrochloride (GndCl) were investigated using small-angle neutron scattering (SANS) and neutron spin-echo spectroscopy (NSE). SANS experiments demonstrated the relevance of intrachain interactions for structural expansion. Using NSE experiments, we observed a high internal flexibility of denatured BSA in addition to center-of-mass diffusion detected by dynamic light scattering. Internal motions measured by NSE were described using concepts based on polymer theory. The contribution of residue-solvent friction was accounted for using the Zimm model including internal friction (ZIF). Disulfide bonds forming loops of amino acids of the peptide backbone have a major impact on internal dynamics that can be interpreted with a reduced set of Zimm modes.

International Curriculums.

ERIC Educational Resources Information Center

Neal, Larry L.

This workshop presentation on international curriculums in the field of parks, recreation, leisure, cultural services, and travel/tourism comments that the literature is replete with articles addressing what the field is about, but not about curriculum issues, models, and structure. It reports an international survey of 12 college educators…

Multilevel Structural Equation Models for the Analysis of Comparative Data on Educational Performance

ERIC Educational Resources Information Center

Goldstein, Harvey; Bonnet, Gerard; Rocher, Thierry

2007-01-01

The Programme for International Student Assessment comparative study of reading performance among 15-year-olds is reanalyzed using statistical procedures that allow the full complexity of the data structures to be explored. The article extends existing multilevel factor analysis and structural equation models and shows how this can extract richer…

Alignment of the system's chief nursing officer: staff or direct line structure?

PubMed

Kerfoot, Karlene M; Luquire, Rosemary

2012-01-01

The role of the system chief nursing officer nationally and internationally has been traditionally structured as a staff model, a direct line model, or a hybrid that includes parts of each model. The choice of structure should be made after a thorough investigation of what outcomes the system wants this position to accomplish, developing the appropriate structure to achieve these outcomes, and then engaging a chief nursing officer with the skills indicated by the type of structure chosen. This article describes these 3 structures and the support infrastructure necessary for each model.

Fast flexible modeling of RNA structure using internal coordinates.

PubMed

Flores, Samuel Coulbourn; Sherman, Michael A; Bruns, Christopher M; Eastman, Peter; Altman, Russ Biagio

2011-01-01

Modeling the structure and dynamics of large macromolecules remains a critical challenge. Molecular dynamics (MD) simulations are expensive because they model every atom independently, and are difficult to combine with experimentally derived knowledge. Assembly of molecules using fragments from libraries relies on the database of known structures and thus may not work for novel motifs. Coarse-grained modeling methods have yielded good results on large molecules but can suffer from difficulties in creating more detailed full atomic realizations. There is therefore a need for molecular modeling algorithms that remain chemically accurate and economical for large molecules, do not rely on fragment libraries, and can incorporate experimental information. RNABuilder works in the internal coordinate space of dihedral angles and thus has time requirements proportional to the number of moving parts rather than the number of atoms. It provides accurate physics-based response to applied forces, but also allows user-specified forces for incorporating experimental information. A particular strength of RNABuilder is that all Leontis-Westhof basepairs can be specified as primitives by the user to be satisfied during model construction. We apply RNABuilder to predict the structure of an RNA molecule with 160 bases from its secondary structure, as well as experimental information. Our model matches the known structure to 10.2 Angstroms RMSD and has low computational expense.

Faculty as Bridges to Co-Curricular Engagement and Community for First-Generation International Students

ERIC Educational Resources Information Center

Glass, Chris R.; Gesing, Peggy; Hales, Angela; Cong, Cong

2017-01-01

The proportion of first-generation international students at US institutions ranges from one-tenth to one-half of the total international student body. First-generation status is an underexplored, and potentially significant, demographic factor in international students' adaptation to college. Researchers used structural equation modelling (SEM)…

International migration network: Topology and modeling

NASA Astrophysics Data System (ADS)

Fagiolo, Giorgio; Mastrorillo, Marina

2013-07-01

This paper studies international migration from a complex-network perspective. We define the international migration network (IMN) as the weighted-directed graph where nodes are world countries and links account for the stock of migrants originated in a given country and living in another country at a given point in time. We characterize the binary and weighted architecture of the network and its evolution over time in the period 1960-2000. We find that the IMN is organized around a modular structure with a small-world binary pattern displaying disassortativity and high clustering, with power-law distributed weighted-network statistics. We also show that a parsimonious gravity model of migration can account for most of observed IMN topological structure. Overall, our results suggest that socioeconomic, geographical, and political factors are more important than local-network properties in shaping the structure of the IMN.

International migration network: topology and modeling.

PubMed

Fagiolo, Giorgio; Mastrorillo, Marina

2013-07-01

This paper studies international migration from a complex-network perspective. We define the international migration network (IMN) as the weighted-directed graph where nodes are world countries and links account for the stock of migrants originated in a given country and living in another country at a given point in time. We characterize the binary and weighted architecture of the network and its evolution over time in the period 1960-2000. We find that the IMN is organized around a modular structure with a small-world binary pattern displaying disassortativity and high clustering, with power-law distributed weighted-network statistics. We also show that a parsimonious gravity model of migration can account for most of observed IMN topological structure. Overall, our results suggest that socioeconomic, geographical, and political factors are more important than local-network properties in shaping the structure of the IMN.

Solution accuracies of finite element reentry heat transfer and thermal stress analyses of Space Shuttle Orbiter

NASA Technical Reports Server (NTRS)

Ko, William L.

1988-01-01

Accuracies of solutions (structural temperatures and thermal stresses) obtained from different thermal and structural FEMs set up for the Space Shuttle Orbiter (SSO) are compared and discussed. For studying the effect of element size on the solution accuracies of heat-transfer and thermal-stress analyses of the SSO, five SPAR thermal models and five NASTRAN structural models were set up for wing midspan bay 3. The structural temperature distribution over the wing skin (lower and upper) surface of one bay was dome shaped and induced more severe thermal stresses in the chordwise direction than in the spanwise direction. The induced thermal stresses were extremely sensitive to slight variation in structural temperature distributions. Both internal convention and internal radiation were found to have equal effects on the SSO.

Irreducible Uncertainty in Terrestrial Carbon Projections

NASA Astrophysics Data System (ADS)

Lovenduski, N. S.; Bonan, G. B.

2016-12-01

We quantify and isolate the sources of uncertainty in projections of carbon accumulation by the ocean and terrestrial biosphere over 2006-2100 using output from Earth System Models participating in the 5th Coupled Model Intercomparison Project. We consider three independent sources of uncertainty in our analysis of variance: (1) internal variability, driven by random, internal variations in the climate system, (2) emission scenario, driven by uncertainty in future radiative forcing, and (3) model structure, wherein different models produce different projections given the same emission scenario. Whereas uncertainty in projections of ocean carbon accumulation by 2100 is 100 Pg C and driven primarily by emission scenario, uncertainty in projections of terrestrial carbon accumulation by 2100 is 50% larger than that of the ocean, and driven primarily by model structure. This structural uncertainty is correlated with emission scenario: the variance associated with model structure is an order of magnitude larger under a business-as-usual scenario (RCP8.5) than a mitigation scenario (RCP2.6). In an effort to reduce this structural uncertainty, we apply various model weighting schemes to our analysis of variance in terrestrial carbon accumulation projections. The largest reductions in uncertainty are achieved when giving all the weight to a single model; here the uncertainty is of a similar magnitude to the ocean projections. Such an analysis suggests that this structural uncertainty is irreducible given current terrestrial model development efforts.

Internalized Homophobia and Relationship Quality among Lesbians, Gay Men, and Bisexuals

ERIC Educational Resources Information Center

Frost, David M.; Meyer, Ilan H.

2009-01-01

The authors examined the associations between internalized homophobia, outness, community connectedness, depressive symptoms, and relationship quality among a diverse community sample of 396 lesbian, gay, and bisexual (LGB) individuals. Structural equation models showed that internalized homophobia was associated with greater relationship problems…

Seasonal meridional energy balance and thermal structure of the atmosphere of Uranus - A radiative-convective-dynamical model

NASA Technical Reports Server (NTRS)

Friedson, James; Ingersoll, Andrew P.

1987-01-01

A model is presented for the thermodynamics of the seasonal meridional energy balance and thermal structure of the Uranian atmosphere. The model considers radiation and small-scale convection, and dynamical heat fluxes due to large-scale baroclinic eddies. Phase oscillations with a period of 0.5 Uranian year are discerned in the total internal power and global enthalpy storage. The variations in the identity of the main transport agent with the magnitude of the internal heat source are discussed. It is shown that meridional heat transport in the atmosphere is sufficient to lower seasonal horizontal temperature contrasts below those predicted with radiative-convection models.

Analytical model of cracking due to rebar corrosion expansion in concrete considering the structure internal force

NASA Astrophysics Data System (ADS)

Lin, Xiangyue; Peng, Minli; Lei, Fengming; Tan, Jiangxian; Shi, Huacheng

2017-12-01

Based on the assumptions of uniform corrosion and linear elastic expansion, an analytical model of cracking due to rebar corrosion expansion in concrete was established, which is able to consider the structure internal force. And then, by means of the complex variable function theory and series expansion technology established by Muskhelishvili, the corresponding stress component functions of concrete around the reinforcement were obtained. Also, a comparative analysis was conducted between the numerical simulation model and present model in this paper. The results show that the calculation results of both methods were consistent with each other, and the numerical deviation was less than 10%, proving that the analytical model established in this paper is reliable.

Explaining Scientists' Plans for International Mobility from a Life Course Perspective

ERIC Educational Resources Information Center

Netz, Nicolai; Jaksztat, Steffen

2017-01-01

We identify factors influencing young scientists' plans for research stays abroad by embedding theories of social inequality, educational decision making, and migration into a life course framework. We test the developed model of international academic mobility by calculating a structural equation model using data from an online survey of…

Modeling potential structure ignitions from flame radiation exposure with implications for wildland/urban interface fire management

Treesearch

Jack D. Cohen; Bret W. Butler

1998-01-01

Residential losses associated with wildland fires have become a serious international fire protection problem. The radiant heat flux from burning vegetation adjacent to a structure is a principal ignition factor. A thermal radiation and ignition model estimated structure ignition potential using designated flame characteristics (inferred from various types and...

A design pathfinder with material correlation points for inflatable systems

NASA Astrophysics Data System (ADS)

Fulcher, Jared Terrell

The incorporation of inflatable structures into aerospace systems can produce significant advantages in stowed volume to mechanical effectiveness and overall weight. Many applications of these ultra-lightweight systems are designed to precisely control internal or external surfaces, or both, to achieve desired performance. The modeling of these structures becomes complex due to the material nonlinearities inherent to the majority of construction materials used in inflatable structures. Furthermore, accurately modeling the response and behavior of the interfacing boundaries that are common to many inflatable systems will lead to better understanding of the entire class of structures. The research presented involved using nonlinear finite element simulations correlated with photogrammetry testing to develop a procedure for defining material properties for commercially available polyurethane-coated woven nylon fabric, which is representative of coated materials that have been proven materials for use in many inflatable systems. Further, the new material model was used to design and develop an inflatable pathfinder system which employs only internal pressure to control an assembly of internal membranes. This canonical inflatable system will be used for exploration and development of general understanding of efficient design methodology and analysis of future systems. Canonical structures are incorporated into the design of the phased pathfinder system to allow for more universal insight. Nonlinear finite element simulations were performed to evaluate the effect of various boundary conditions, loading configurations, and material orientations on the geometric precision of geometries representing typical internal/external surfaces commonly incorporated into inflatable pathfinder system. The response of the inflatable system to possible damage was also studied using nonlinear finite element simulations. Development of a correlated material model for analysis of the inflatable pathfinder system has improved the efficiency of design and analysis techniques of future inflatable structures. KEYWORDS: Nonlinear Finite Element, Inflatable Structures, Gossamer Space Systems, Photogrammetry Measurements, Coated Woven Fabric.

Research environments that promote integrity.

PubMed

Jeffers, Brenda Recchia; Whittemore, Robin

2005-01-01

The body of empirical knowledge about research integrity and the factors that promote research integrity in nursing research environments remains small. To propose an internal control model as an innovative framework for the design and structure of nursing research environments that promote integrity. An internal control model is adapted to illustrate its use for conceptualizing and designing research environments that promote integrity. The internal control model integrates both the organizational elements necessary to promote research integrity and the processes needed to assess research environments. The model provides five interrelated process components within which any number of research integrity variables and processes may be used and studied: internal control environment, risk assessment, internal control activities, monitoring, and information and communication. The components of the proposed research integrity internal control model proposed comprise an integrated conceptualization of the processes that provide reasonable assurance that research integrity will be promoted within the nursing research environment. Schools of nursing can use the model to design, implement, and evaluate systems that promote research integrity. The model process components need further exploration to substantiate the use of the model in nursing research environments.

Advancing viral RNA structure prediction: measuring the thermodynamics of pyrimidine-rich internal loops

PubMed Central

Phan, Andy; Mailey, Katherine; Saeki, Jessica; Gu, Xiaobo

2017-01-01

Accurate thermodynamic parameters improve RNA structure predictions and thus accelerate understanding of RNA function and the identification of RNA drug binding sites. Many viral RNA structures, such as internal ribosome entry sites, have internal loops and bulges that are potential drug target sites. Current models used to predict internal loops are biased toward small, symmetric purine loops, and thus poorly predict asymmetric, pyrimidine-rich loops with >6 nucleotides (nt) that occur frequently in viral RNA. This article presents new thermodynamic data for 40 pyrimidine loops, many of which can form UU or protonated CC base pairs. Uracil and protonated cytosine base pairs stabilize asymmetric internal loops. Accurate prediction rules are presented that account for all thermodynamic measurements of RNA asymmetric internal loops. New loop initiation terms for loops with >6 nt are presented that do not follow previous assumptions that increasing asymmetry destabilizes loops. Since the last 2004 update, 126 new loops with asymmetry or sizes greater than 2 × 2 have been measured. These new measurements significantly deepen and diversify the thermodynamic database for RNA. These results will help better predict internal loops that are larger, pyrimidine-rich, and occur within viral structures such as internal ribosome entry sites. PMID:28213527

External validity of a hierarchical dimensional model of child and adolescent psychopathology: Tests using confirmatory factor analyses and multivariate behavior genetic analyses.

PubMed

Waldman, Irwin D; Poore, Holly E; van Hulle, Carol; Rathouz, Paul J; Lahey, Benjamin B

2016-11-01

Several recent studies of the hierarchical phenotypic structure of psychopathology have identified a General psychopathology factor in addition to the more expected specific Externalizing and Internalizing dimensions in both youth and adult samples and some have found relevant unique external correlates of this General factor. We used data from 1,568 twin pairs (599 MZ & 969 DZ) age 9 to 17 to test hypotheses for the underlying structure of youth psychopathology and the external validity of the higher-order factors. Psychopathology symptoms were assessed via structured interviews of caretakers and youth. We conducted phenotypic analyses of competing structural models using Confirmatory Factor Analysis and used Structural Equation Modeling and multivariate behavior genetic analyses to understand the etiology of the higher-order factors and their external validity. We found that both a General factor and specific Externalizing and Internalizing dimensions are necessary for characterizing youth psychopathology at both the phenotypic and etiologic levels, and that the 3 higher-order factors differed substantially in the magnitudes of their underlying genetic and environmental influences. Phenotypically, the specific Externalizing and Internalizing dimensions were slightly negatively correlated when a General factor was included, which reflected a significant inverse correlation between the nonshared environmental (but not genetic) influences on Internalizing and Externalizing. We estimated heritability of the general factor of psychopathology for the first time. Its moderate heritability suggests that it is not merely an artifact of measurement error but a valid construct. The General, Externalizing, and Internalizing factors differed in their relations with 3 external validity criteria: mother's smoking during pregnancy, parent's harsh discipline, and the youth's association with delinquent peers. Multivariate behavior genetic analyses supported the external validity of the 3 higher-order factors by suggesting that the General, Externalizing, and Internalizing factors were correlated with peer delinquency and parent's harsh discipline for different etiologic reasons. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

A Point Rainfall Generator With Internal Storm Structure

NASA Astrophysics Data System (ADS)

Marien, J. L.; Vandewiele, G. L.

1986-04-01

A point rainfall generator is a probabilistic model for the time series of rainfall as observed in one geographical point. The main purpose of such a model is to generate long synthetic sequences of rainfall for simulation studies. The present generator is a continuous time model based on 13.5 years of 10-min point rainfalls observed in Belgium and digitized with a resolution of 0.1 mm. The present generator attempts to model all features of the rainfall time series which are important for flood studies as accurately as possible. The original aspects of the model are on the one hand the way in which storms are defined and on the other hand the theoretical model for the internal storm characteristics. The storm definition has the advantage that the important characteristics of successive storms are fully independent and very precisely modelled, even on time bases as small as 10 min. The model of the internal storm characteristics has a strong theoretical structure. This fact justifies better the extrapolation of this model to severe storms for which the data are very sparse. This can be important when using the model to simulate severe flood events.

Structural Validity of CLASS K-3 in Primary Grades: Testing Alternative Models

ERIC Educational Resources Information Center

Sandilos, Lia E.; Shervey, Sarah Wollersheim; DiPerna, James C.; Lei, Puiwa; Cheng, Weiyi

2017-01-01

This study examined the internal structure of the Classroom Assessment Scoring System (CLASS; K-3 version). The original CLASS K-3 model (Pianta, La Paro, & Hamre, 2008) and 5 alternative models were tested using confirmatory factor analysis with a sample of first- and second-grade classrooms (N = 141). Findings indicated that a slightly…

Evaluation of a Structural Model of Objectification Theory and Eating Disorder Symptomatology among European American and African American Undergraduate Women

ERIC Educational Resources Information Center

Mitchell, Karen S.; Mazzeo, Suzanne E.

2009-01-01

This study evaluated a structural equation model of objectification theory among European American (EA; n = 408) and African American women (AA; n = 233). Modeling results indicated a particularly strong association between thin-ideal internalization/body monitoring and eating disorder symptoms, with weaker relationships among body…

Testing Models of Psychopathology in Preschool-aged Children Using a Structured Interview-based Assessment

PubMed Central

Dougherty, Lea R.; Bufferd, Sara J.; Carlson, Gabrielle A.; Klein, Daniel N.

2014-01-01

A number of studies have found that broadband internalizing and externalizing factors provide a parsimonious framework for understanding the structure of psychopathology across childhood, adolescence, and adulthood. However, few of these studies have examined psychopathology in young children, and several recent studies have found support for alternative models, including a bi-factor model with common and specific factors. The present study used parents’ (typically mothers’) reports on a diagnostic interview in a community sample of 3-year old children (n=541; 53.9 % male) to compare the internalizing-externalizing latent factor model with a bi-factor model. The bi-factor model provided a better fit to the data. To test the concurrent validity of this solution, we examined associations between this model and paternal reports and laboratory observations of child temperament. The internalizing factor was associated with low levels of surgency and high levels of fear; the externalizing factor was associated with high levels of surgency and disinhibition and low levels of effortful control; and the common factor was associated with high levels of surgency and negative affect and low levels of effortful control. These results suggest that psychopathology in preschool-aged children may be explained by a single, common factor influencing nearly all disorders and unique internalizing and externalizing factors. These findings indicate that shared variance across internalizing and externalizing domains is substantial and are consistent with recent suggestions that emotion regulation difficulties may be a common vulnerability for a wide array of psychopathology. PMID:24652485

Structural Configuration Analysis of Crew Exploration Vehicle Concepts

NASA Technical Reports Server (NTRS)

Mukhopadhyay, V.

2006-01-01

Structural configuration modeling and finite element analysis of crew exploration vehicle (CEV) concepts are presented. In the structural configuration design approach, parametric solid models of the pressurized shell and tanks are developed. The CEV internal cabin pressure is same as in the International Space Station (ISS) to enable docking with the ISS without an intermediate airlock. Effects of this internal pressure load on the stress distribution, factor of safety, mass and deflections are investigated. Uniform 7 mm thick skin shell, 5 mm thick shell with ribs and frames, and isogrid skin construction options are investigated. From this limited study, the isogrid construction appears to provide most strength/mass ratio. Initial finite element analysis results on the service module tanks are also presented. These rapid finite element analyses, stress and factor of safety distribution results are presented as a part of lessons learned and to build up a structural mass estimation and sizing database for future technology support. This rapid structural analysis process may also facilitate better definition of the vehicles and components for rapid prototyping. However, these structural analysis results are highly conceptual and exploratory in nature and do not reflect current configuration designs being conducted at the program level by NASA and industry.

A discrete time-varying internal model-based approach for high precision tracking of a multi-axis servo gantry.

PubMed

Zhang, Zhen; Yan, Peng; Jiang, Huan; Ye, Peiqing

2014-09-01

In this paper, we consider the discrete time-varying internal model-based control design for high precision tracking of complicated reference trajectories generated by time-varying systems. Based on a novel parallel time-varying internal model structure, asymptotic tracking conditions for the design of internal model units are developed, and a low order robust time-varying stabilizer is further synthesized. In a discrete time setting, the high precision tracking control architecture is deployed on a Voice Coil Motor (VCM) actuated servo gantry system, where numerical simulations and real time experimental results are provided, achieving the tracking errors around 3.5‰ for frequency-varying signals. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

International Space Station Model Correlation Analysis

NASA Technical Reports Server (NTRS)

Laible, Michael R.; Fitzpatrick, Kristin; Hodge, Jennifer; Grygier, Michael

2018-01-01

This paper summarizes the on-orbit structural dynamic data and the related modal analysis, model validation and correlation performed for the International Space Station (ISS) configuration ISS Stage ULF7, 2015 Dedicated Thruster Firing (DTF). The objective of this analysis is to validate and correlate the analytical models used to calculate the ISS internal dynamic loads and compare the 2015 DTF with previous tests. During the ISS configurations under consideration, on-orbit dynamic measurements were collected using the three main ISS instrumentation systems; Internal Wireless Instrumentation System (IWIS), External Wireless Instrumentation System (EWIS) and the Structural Dynamic Measurement System (SDMS). The measurements were recorded during several nominal on-orbit DTF tests on August 18, 2015. Experimental modal analyses were performed on the measured data to extract modal parameters including frequency, damping, and mode shape information. Correlation and comparisons between test and analytical frequencies and mode shapes were performed to assess the accuracy of the analytical models for the configurations under consideration. These mode shapes were also compared to earlier tests. Based on the frequency comparisons, the accuracy of the mathematical models is assessed and model refinement recommendations are given. In particular, results of the first fundamental mode will be discussed, nonlinear results will be shown, and accelerometer placement will be assessed.

Effects of complex internal structures on rheology of multiple emulsions particles in 2D from a boundary integral method.

PubMed

Wang, Jingtao; Liu, Jinxia; Han, Junjie; Guan, Jing

2013-02-08

A boundary integral method is developed to investigate the effects of inner droplets and asymmetry of internal structures on rheology of two-dimensional multiple emulsion particles with arbitrary numbers of layers and droplets within each layer. Under a modest extensional flow, the number increment of layers and inner droplets, and the collision among inner droplets subject the particle to stronger shears. In addition, the coalescence or release of inner droplets changes the internal structure of the multiple emulsion particles. Since the rheology of such particles is sensitive to internal structures and their change, modeling them as the core-shell particles to obtain the viscosity equation of a single particle should be modified by introducing the time-dependable volume fraction Φ(t) of the core instead of the fixed Φ. An asymmetric internal structure induces an oriented contact and merging of the outer and inner interface. The start time of the interface merging is controlled by adjusting the viscosity ratio and enhancing the asymmetry, which is promising in the controlled release of inner droplets through hydrodynamics for targeted drug delivery.

Effect of Topology Structure on the Output Performance of an Automobile Exhaust Thermoelectric Generator

NASA Astrophysics Data System (ADS)

Fang, W.; Quan, S. H.; Xie, C. J.; Ran, B.; Li, X. L.; Wang, L.; Jiao, Y. T.; Xu, T. W.

2017-05-01

The majority of the thermal energy released in an automotive internal combustion cycle is exhausted as waste heat through the tail pipe. This paper describes an automobile exhaust thermoelectric generator (AETEG), designed to recycle automobile waste heat. A model of the output characteristics of each thermoelectric device was established by testing their open circuit voltage and internal resistance, and combining the output characteristics. To better describe the relationship, the physical model was transformed into a topological model. The connection matrix was used to describe the relationship between any two thermoelectric devices in the topological structure. Different topological structures produced different power outputs; their output power was maximised by using an iterative algorithm to optimize the series-parallel electrical topology structure. The experimental results have shown that the output power of the optimal topology structure increases by 18.18% and 29.35% versus that of a pure in-series or parallel topology, respectively, and by 10.08% versus a manually defined structure (based on user experience). The thermoelectric conversion device increased energy efficiency by 40% when compared with a traditional car.

Peer Victimization as a Mediator of the Relation between Facial Attractiveness and Internalizing Problems

PubMed Central

Rosen, Lisa H.; Underwood, Marion K.; Beron, Kurt J.

2011-01-01

This study examined the relations between facial attractiveness, peer victimization, and internalizing problems in early adolescence. We hypothesized that experiences of peer victimization would partially mediate the relationship between attractiveness and internalizing problems. Ratings of attractiveness were obtained from standardized photographs of participants (93 girls, 82 boys). Teachers provided information regarding peer victimization experiences in sixth grade, and seventh grade teachers assessed internalizing problems. Attractiveness was negatively correlated with victimization and internalizing problems. Experiences of peer victimization were positively correlated with internalizing problems. Structural equation modeling provided support for the hypothesized model of peer victimization partially mediating the relationship between attractiveness and internalizing problems. Implications for intervention programs and future research directions are discussed. PMID:21984861

Physical models have gender-specific effects on student understanding of protein structure-function relationships.

PubMed

Forbes-Lorman, Robin M; Harris, Michelle A; Chang, Wesley S; Dent, Erik W; Nordheim, Erik V; Franzen, Margaret A

2016-07-08

Understanding how basic structural units influence function is identified as a foundational/core concept for undergraduate biological and biochemical literacy. It is essential for students to understand this concept at all size scales, but it is often more difficult for students to understand structure-function relationships at the molecular level, which they cannot as effectively visualize. Students need to develop accurate, 3-dimensional mental models of biomolecules to understand how biomolecular structure affects cellular functions at the molecular level, yet most traditional curricular tools such as textbooks include only 2-dimensional representations. We used a controlled, backward design approach to investigate how hand-held physical molecular model use affected students' ability to logically predict structure-function relationships. Brief (one class period) physical model use increased quiz score for females, whereas there was no significant increase in score for males using physical models. Females also self-reported higher learning gains in their understanding of context-specific protein function. Gender differences in spatial visualization may explain the gender-specific benefits of physical model use observed. © 2016 The Authors Biochemistry and Molecular Biology Education published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 44(4):326-335, 2016. © 2016 The International Union of Biochemistry and Molecular Biology.

Perceived Social Relationships and Science Learning Outcomes for Taiwanese Eighth Graders: Structural Equation Modeling with a Complex Sampling Consideration

ERIC Educational Resources Information Center

Jen, Tsung-Hau; Lee, Che-Di; Chien, Chin-Lung; Hsu, Ying-Shao; Chen, Kuan-Ming

2013-01-01

Based on the Trends in International Mathematics and Science Study 2007 study and a follow-up national survey, data for 3,901 Taiwanese grade 8 students were analyzed using structural equation modeling to confirm a social-relation-based affection-driven model (SRAM). SRAM hypothesized relationships among students' perceived social relationships in…

Internal quantum efficiency enhancement of GaInN/GaN quantum-well structures using Ag nanoparticles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iida, Daisuke; Department of Photonics Engineering, Technical University of Denmark, 2800 Lyngby; Faculty of Science and Technology, Meijo University, 1-501 Shiogamaguchi Tempaku, 468-8502 Nagoya

2015-09-15

We report internal quantum efficiency enhancement of thin p-GaN green quantum-well structure using self-assembled Ag nanoparticles. Temperature dependent photoluminescence measurements are conducted to determine the internal quantum efficiency. The impact of excitation power density on the enhancement factor is investigated. We obtain an internal quantum efficiency enhancement by a factor of 2.3 at 756 W/cm{sup 2}, and a factor of 8.1 at 1 W/cm{sup 2}. A Purcell enhancement up to a factor of 26 is estimated by fitting the experimental results to a theoretical model for the efficiency enhancement factor.

RCWA and FDTD modeling of light emission from internally structured OLEDs.

PubMed

Callens, Michiel Koen; Marsman, Herman; Penninck, Lieven; Peeters, Patrick; de Groot, Harry; ter Meulen, Jan Matthijs; Neyts, Kristiaan

2014-05-05

We report on the fabrication and simulation of a green OLED with an Internal Light Extraction (ILE) layer. The optical behavior of these devices is simulated using both Rigorous Coupled Wave Analysis (RCWA) and Finite Difference Time-Domain (FDTD) methods. Results obtained using these two different techniques show excellent agreement and predict the experimental results with good precision. By verifying the validity of both simulation methods on the internal light extraction structure we pave the way to optimization of ILE layers using either of these methods.

Finite Element Modeling of the NASA Langley Aluminum Testbed Cylinder

NASA Technical Reports Server (NTRS)

Grosveld, Ferdinand W.; Pritchard, Joselyn I.; Buehrle, Ralph D.; Pappa, Richard S.

2002-01-01

The NASA Langley Aluminum Testbed Cylinder (ATC) was designed to serve as a universal structure for evaluating structural acoustic codes, modeling techniques and optimization methods used in the prediction of aircraft interior noise. Finite element models were developed for the components of the ATC based on the geometric, structural and material properties of the physical test structure. Numerically predicted modal frequencies for the longitudinal stringer, ring frame and dome component models, and six assembled ATC configurations were compared with experimental modal survey data. The finite element models were updated and refined, using physical parameters, to increase correlation with the measured modal data. Excellent agreement, within an average 1.5% to 2.9%, was obtained between the predicted and measured modal frequencies of the stringer, frame and dome components. The predictions for the modal frequencies of the assembled component Configurations I through V were within an average 2.9% and 9.1%. Finite element modal analyses were performed for comparison with 3 psi and 6 psi internal pressurization conditions in Configuration VI. The modal frequencies were predicted by applying differential stiffness to the elements with pressure loading and creating reduced matrices for beam elements with offsets inside external superelements. The average disagreement between the measured and predicted differences for the 0 psi and 6 psi internal pressure conditions was less than 0.5%. Comparably good agreement was obtained for the differences between the 0 psi and 3 psi measured and predicted internal pressure conditions.

Epidemic spreading on complex networks with community structures

PubMed Central

Stegehuis, Clara; van der Hofstad, Remco; van Leeuwaarden, Johan S. H.

2016-01-01

Many real-world networks display a community structure. We study two random graph models that create a network with similar community structure as a given network. One model preserves the exact community structure of the original network, while the other model only preserves the set of communities and the vertex degrees. These models show that community structure is an important determinant of the behavior of percolation processes on networks, such as information diffusion or virus spreading: the community structure can both enforce as well as inhibit diffusion processes. Our models further show that it is the mesoscopic set of communities that matters. The exact internal structures of communities barely influence the behavior of percolation processes across networks. This insensitivity is likely due to the relative denseness of the communities. PMID:27440176

HARMONY: a server for the assessment of protein structures

PubMed Central

Pugalenthi, G.; Shameer, K.; Srinivasan, N.; Sowdhamini, R.

2006-01-01

Protein structure validation is an important step in computational modeling and structure determination. Stereochemical assessment of protein structures examine internal parameters such as bond lengths and Ramachandran (φ,ψ) angles. Gross structure prediction methods such as inverse folding procedure and structure determination especially at low resolution can sometimes give rise to models that are incorrect due to assignment of misfolds or mistracing of electron density maps. Such errors are not reflected as strain in internal parameters. HARMONY is a procedure that examines the compatibility between the sequence and the structure of a protein by assigning scores to individual residues and their amino acid exchange patterns after considering their local environments. Local environments are described by the backbone conformation, solvent accessibility and hydrogen bonding patterns. We are now providing HARMONY through a web server such that users can submit their protein structure files and, if required, the alignment of homologous sequences. Scores are mapped on the structure for subsequent examination that is useful to also recognize regions of possible local errors in protein structures. HARMONY server is located at PMID:16844999

Bright-field electron tomography of individual inorganic fullerene-like structures

NASA Astrophysics Data System (ADS)

Bar Sadan, Maya; Wolf, Sharon G.; Houben, Lothar

2010-03-01

Nanotubes and fullerene-like nanoparticles of various inorganic layered compounds have been studied extensively in recent years. Their characterisation on the atomic scale has proven essential for progress in synthesis as well as for the theoretical modelling of their physical properties. We show that with electron tomography it is possible to achieve a reliable reconstruction of the 3D structure of nested WS2 or MoS2 fullerene-like and nanotube structures with sub-nanometre resolution using electron microscopes that are not aberration-corrected. Model-based simulations were used to identify imaging parameters, under which structural features such as the shell structure can be retained in the tomogram reconstructed from bright-field micrographs. The isolation of a particle out of an agglomerate for the analysis of a single structure and its interconnection with other particles is facilitated through the tomograms. The internal structure of the layers within the particle alongside the shape and content of its internal void are reconstructed. The tomographic reconstruction yields insights regarding the growth process as well as structural defects, such as non-continuous layers, which relate to the lubrication properties.Nanotubes and fullerene-like nanoparticles of various inorganic layered compounds have been studied extensively in recent years. Their characterisation on the atomic scale has proven essential for progress in synthesis as well as for the theoretical modelling of their physical properties. We show that with electron tomography it is possible to achieve a reliable reconstruction of the 3D structure of nested WS2 or MoS2 fullerene-like and nanotube structures with sub-nanometre resolution using electron microscopes that are not aberration-corrected. Model-based simulations were used to identify imaging parameters, under which structural features such as the shell structure can be retained in the tomogram reconstructed from bright-field micrographs. The isolation of a particle out of an agglomerate for the analysis of a single structure and its interconnection with other particles is facilitated through the tomograms. The internal structure of the layers within the particle alongside the shape and content of its internal void are reconstructed. The tomographic reconstruction yields insights regarding the growth process as well as structural defects, such as non-continuous layers, which relate to the lubrication properties. Electronic supplementary information (ESI) available: Figs. S1 and S2 and movies S1-S6. See DOI: 10.1039/b9nr00251k

Human substantia nigra and ventral tegmental area involvement in computing social error signals during the ultimatum game

PubMed Central

Hétu, Sébastien; Luo, Yi; D’Ardenne, Kimberlee; Lohrenz, Terry

2017-01-01

Abstract As models of shared expectations, social norms play an essential role in our societies. Since our social environment is changing constantly, our internal models of it also need to change. In humans, there is mounting evidence that neural structures such as the insula and the ventral striatum are involved in detecting norm violation and updating internal models. However, because of methodological challenges, little is known about the possible involvement of midbrain structures in detecting norm violation and updating internal models of our norms. Here, we used high-resolution cardiac-gated functional magnetic resonance imaging and a norm adaptation paradigm in healthy adults to investigate the role of the substantia nigra/ventral tegmental area (SN/VTA) complex in tracking signals related to norm violation that can be used to update internal norms. We show that the SN/VTA codes for the norm’s variance prediction error (PE) and norm PE with spatially distinct regions coding for negative and positive norm PE. These results point to a common role played by the SN/VTA complex in supporting both simple reward-based and social decision making. PMID:28981876

Advancing viral RNA structure prediction: measuring the thermodynamics of pyrimidine-rich internal loops.

PubMed

Phan, Andy; Mailey, Katherine; Saeki, Jessica; Gu, Xiaobo; Schroeder, Susan J

2017-05-01

Accurate thermodynamic parameters improve RNA structure predictions and thus accelerate understanding of RNA function and the identification of RNA drug binding sites. Many viral RNA structures, such as internal ribosome entry sites, have internal loops and bulges that are potential drug target sites. Current models used to predict internal loops are biased toward small, symmetric purine loops, and thus poorly predict asymmetric, pyrimidine-rich loops with >6 nucleotides (nt) that occur frequently in viral RNA. This article presents new thermodynamic data for 40 pyrimidine loops, many of which can form UU or protonated CC base pairs. Uracil and protonated cytosine base pairs stabilize asymmetric internal loops. Accurate prediction rules are presented that account for all thermodynamic measurements of RNA asymmetric internal loops. New loop initiation terms for loops with >6 nt are presented that do not follow previous assumptions that increasing asymmetry destabilizes loops. Since the last 2004 update, 126 new loops with asymmetry or sizes greater than 2 × 2 have been measured. These new measurements significantly deepen and diversify the thermodynamic database for RNA. These results will help better predict internal loops that are larger, pyrimidine-rich, and occur within viral structures such as internal ribosome entry sites. © 2017 Phan et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

Internal Structural Design of the Common Research Model Wing Box for Aeroelastic Tailoring

NASA Technical Reports Server (NTRS)

Jutte, Christine V.; Stanford, Bret K.; Wieseman, Carol D.

2015-01-01

This work explores the use of alternative internal structural designs within a full-scale wing box structure for aeroelastic tailoring, with a focus on curvilinear spars, ribs, and stringers. The baseline wing model is a fully-populated, cantilevered wing box structure of the Common Research Model (CRM). Metrics of interest include the wing weight, the onset of dynamic flutter, and the static aeroelastic stresses. Twelve parametric studies alter the number of internal structural members along with their location, orientation, and curvature. Additional evaluation metrics are considered to identify design trends that lead to lighter-weight, aeroelastically stable wing designs. The best designs of the individual studies are compared and discussed, with a focus on weight reduction and flutter resistance. The largest weight reductions were obtained by removing the inner spar, and performance was maintained by shifting stringers forward and/or using curvilinear ribs: 5.6% weight reduction, a 13.9% improvement in flutter speed, but a 3.0% increase in stress levels. Flutter resistance was also maintained using straight-rotated ribs although the design had a 4.2% lower flutter speed than the curved ribs of similar weight and stress levels were higher. For some configurations, the differences between curved and straight ribs were smaller, which provides motivation for future optimization-based studies to fully exploit the trade-offs.

A Fragment-Cloud Approach for Modeling Atmospheric Breakup of Asteroids with Varied Internal Structures

NASA Astrophysics Data System (ADS)

Wheeler, Lorien; Mathias, Donovan; NASA Engineering Risk Assessment Team, NASA Asteroid Threat Assessment Project

2016-10-01

As an asteroid descends toward Earth, it deposits energy in the atmosphere through aerodynamic drag and ablation. Asteroid impact risk assessments rely on energy deposition estimates to predict blast overpressures and ground damage that may result from an airburst, such as the one that occurred over Chelyabinsk, Russia in 2013. The rates and altitudes at which energy is deposited along the entry trajectory depend upon how the bolide fragments, which in turn depends upon its internal structure and composition. In this work, an analytic asteroid fragmentation model has been developed to model the atmospheric breakup and resulting energy deposition of asteroids with a range of internal structures. The modeling approach combines successive fragmentation of larger independent pieces with aggregate debris clouds released with each fragmentation event. The model can vary the number and masses of fragments produced, the amount of mass released as debris clouds, and the size-strength scaling used to increase the robustness of smaller fragments. The initial asteroid body can be seeded with a distribution of independent fragment sizes amid a remaining debris mass to represent loose rubble pile conglomerations, or can be defined as a monolith with an outer regolith layer. This approach enables the model to represent a range of breakup behaviors and reproduce detailed energy deposition features such as multiple flares due to successive burst events, high-altitude regolith blow-off, or initial disruption of rubble piles followed by more energetic breakup of the constituent boulders. These capabilities provide a means to investigate sensitivities of ground damage to potential variations in asteroid structure.

How things fall apart: understanding the nature of internalizing through its relationship with impairment.

PubMed

Markon, Kristian E

2010-08-01

The literature suggests that internalizing psychopathology relates to impairment incrementally and gradually. However, the form of this relationship has not been characterized. This form is critical to understanding internalizing psychopathology, as it is possible that internalizing may accelerate in effect at some level of severity, defining a natural boundary of abnormality. Here, a novel method-semiparametric structural equation modeling-was used to model the relationship between internalizing and impairment in a sample of 8,580 individuals from the 2000 British Office for National Statistics Survey of Psychiatric Morbidity, a large, population-representative study of psychopathology. This method allows one to model relationships between latent internalizing and impairment without assuming any particular form a priori and to compare models in which the relationship is constant and linear. Results suggest that the relationship between internalizing and impairment is in fact linear and constant across the entire range of internalizing variation and that it is impossible to nonarbitrarily define a specific level of internalizing beyond which consequences suddenly become catastrophic in nature. Results demonstrate the phenomenological continuity of internalizing psychopathology, highlight the importance of impairment as well as symptoms, and have clear implications for defining mental disorder. Copyright 2010 APA, all rights reserved

A ‘frozen volume’ transition model and working mechanism for the shape memory effect in amorphous polymers

NASA Astrophysics Data System (ADS)

Lu, Haibao; Wang, Xiaodong; Yao, Yongtao; Qing Fu, Yong

2018-06-01

Phenomenological models based on frozen volume parameters could well predict shape recovery behavior of shape memory polymers (SMPs), but the physical meaning of using the frozen volume parameters to describe thermomechanical properties has not been well-established. In this study, the fundamental working mechanisms of the shape memory effect (SME) in amorphous SMPs, whose temperature-dependent viscoelastic behavior follows the Eyring equation, have been established with the considerations of both internal stress and its resulted frozen volume. The stress-strain constitutive relation was initially modeled to quantitatively describe effects of internal stresses at the macromolecular scale based on the transient network theory. A phenomenological ‘frozen volume’ model was then established to characterize the macromolecule structure and SME of amorphous SMPs based on a two-site stress-relaxation model. Effects of the internal stress, frozen volume and strain rate on shape memory behavior and thermomechanical properties of the SMP were investigated. Finally, the simulation results were compared with the experimental results reported in the literature, and good agreements between the theoretical and experimental results were achieved. The novelty and key differences of our newly proposed model with respect to the previous reports are (1). The ‘frozen volume’ in our study is caused by the internal stress and governed by the two-site model theory, thus has a good physical meaning. (2). The model can be applied to characterize and predict both the thermal and thermomechanical behaviors of SMPs based on the constitutive relationship with internal stress parameters. It is expected to provide a power tool to investigate the thermomechanical behavior of the SMPs, of which both the macromolecular structure characteristics and SME could be predicted using this ‘frozen volume’ model.

Sources of motivation, interpersonal conflict management styles, and leadership effectiveness: a structural model.

PubMed

Barbuto, John E; Xu, Ye

2006-02-01

126 leaders and 624 employees were sampled to test the relationship between sources of motivation and conflict management styles of leaders and how these variables influence effectiveness of leadership. Five sources of motivation measured by the Motivation Sources Inventory were tested-intrinsic process, instrumental, self-concept external, self-concept internal, and goal internalization. These sources of work motivation were associated with Rahim's modes of interpersonal conflict management-dominating, avoiding, obliging, complying, and integrating-and to perceived leadership effectiveness. A structural equation model tested leaders' conflict management styles and leadership effectiveness based upon different sources of work motivation. The model explained variance for obliging (65%), dominating (79%), avoiding (76%), and compromising (68%), but explained little variance for integrating (7%). The model explained only 28% of the variance in leader effectiveness.

Determination of effective loss factors in reduced SEA models

NASA Astrophysics Data System (ADS)

Chimeno Manguán, M.; Fernández de las Heras, M. J.; Roibás Millán, E.; Simón Hidalgo, F.

2017-01-01

The definition of Statistical Energy Analysis (SEA) models for large complex structures is highly conditioned by the classification of the structure elements into a set of coupled subsystems and the subsequent determination of the loss factors representing both the internal damping and the coupling between subsystems. The accurate definition of the complete system can lead to excessively large models as the size and complexity increases. This fact can also rise practical issues for the experimental determination of the loss factors. This work presents a formulation of reduced SEA models for incomplete systems defined by a set of effective loss factors. This reduced SEA model provides a feasible number of subsystems for the application of the Power Injection Method (PIM). For structures of high complexity, their components accessibility can be restricted, for instance internal equipments or panels. For these cases the use of PIM to carry out an experimental SEA analysis is not possible. New methods are presented for this case in combination with the reduced SEA models. These methods allow defining some of the model loss factors that could not be obtained through PIM. The methods are validated with a numerical analysis case and they are also applied to an actual spacecraft structure with accessibility restrictions: a solar wing in folded configuration.

Experimental study and numerical simulation on the structural and mechanical properties of Typha leaves through multimodal microscopy approaches.

PubMed

Liu, Jingjing; Zhang, Zhihui; Yu, Zhenglei; Liang, Yunhong; Li, Xiujuan; Ren, Luquan

2018-01-01

The Typha leaf, with special multi-level structure, low density and excellent mechanical properties, is an ideal bionic prototype utilized for lightweight design. In order to further study the relationship between the structure and mechanical properties, the three-dimensional macroscopic morphology of Typha leaves was characterized by micro computed tomography (Micro-CT) and its internal microstructure was observed by scanning electron microscopy (SEM). The combination of experimental and computational research was carried out in this paper, to reveal and verify the effect of multi-level structure on the mechanical properties. A universal testing machine and a self-developed mechanical testing apparatus with high precision and low load were used to measure the mechanical properties of the axial compression and lateral bending of the leaves, respectively. Three models with different internal structures were established based on the above-mentioned three-dimensional morphologies. The result demonstrated that the structure of partitions and diaphragms within the Typha leaf could form a reinforcement ribs structure which could provide multiple load paths and make the process of compression and bending difficult. The further nonlinear finite element analysis through LS-DYNA proved that internal structure could improve the ability of the models to resist compression and deformation. The investigation can be the reference for lightweight thin-walled structure design and inspire the application of the bionic structural materials. Copyright © 2017 Elsevier Ltd. All rights reserved.

Closed-cell crystalline foams: self-assembling, resonant metamaterials.

PubMed

Spadoni, Alessandro; Höhler, Reinhard; Cohen-Addad, Sylvie; Dorodnitsyn, Vladimir

2014-04-01

Internal degrees of freedom and periodic structure are critical requirements in the design of acoustic/elastic metamaterials since they can give rise to extraordinary properties like negative effective mass and stiffness. However, they are challenging to realize in three dimensions. Closed-cell, crystalline foams are a particularly advantageous basis to develop metamaterials as they intrinsically have a complex microstructure, exhibiting internal resonances. Recently self-assembly techniques have been implemented to produce such foams: a Kelvin (body centered cubic) foam, a face centered cubic foam, and a Weaire-Phelan structure. Numerical models are employed to demonstrate that such foams are superanisotropic, selectively behaving as a fluid or a solid, pentamode solids as a result of fluid-structure interaction, in addition to having regimes characterized by film resonances and high density of states. Microstructural deformations obtained from numerical models allow the derivation of equivalent mechanical models.

Space shuttle solid rocket booster water entry cavity collapse loads

NASA Technical Reports Server (NTRS)

Keefe, R. T.; Rawls, E. A.; Kross, D. A.

1982-01-01

Solid rocket booster cavity collapse flight measurements included external pressures on the motor case and aft skirt, internal motor case pressures, accelerometers located in the forward skirt, mid-body area, and aft skirt, as well as strain gages located on the skin of the motor case. This flight data yielded applied pressure longitudinal and circumferential distributions which compare well with model test predictions. The internal motor case ullage pressure, which is below atmospheric due to the rapid cooling of the hot internal gas, was more severe (lower) than anticipated due to the ullage gas being hotter than predicted. The structural dynamic response characteristics were as expected. Structural ring and wall damage are detailed and are considered to be attributable to the direct application of cavity collapse pressure combined with the structurally destabilizing, low internal motor case pressure.

Consistency of internal fluxes in a hydrological model running at multiple time steps

NASA Astrophysics Data System (ADS)

Ficchi, Andrea; Perrin, Charles; Andréassian, Vazken

2016-04-01

Improving hydrological models remains a difficult task and many ways can be explored, among which one can find the improvement of spatial representation, the search for more robust parametrization, the better formulation of some processes or the modification of model structures by trial-and-error procedure. Several past works indicate that model parameters and structure can be dependent on the modelling time step, and there is thus some rationale in investigating how a model behaves across various modelling time steps, to find solutions for improvements. Here we analyse the impact of data time step on the consistency of the internal fluxes of a rainfall-runoff model run at various time steps, by using a large data set of 240 catchments. To this end, fine time step hydro-climatic information at sub-hourly resolution is used as input of a parsimonious rainfall-runoff model (GR) that is run at eight different model time steps (from 6 minutes to one day). The initial structure of the tested model (i.e. the baseline) corresponds to the daily model GR4J (Perrin et al., 2003), adapted to be run at variable sub-daily time steps. The modelled fluxes considered are interception, actual evapotranspiration and intercatchment groundwater flows. Observations of these fluxes are not available, but the comparison of modelled fluxes at multiple time steps gives additional information for model identification. The joint analysis of flow simulation performance and consistency of internal fluxes at different time steps provides guidance to the identification of the model components that should be improved. Our analysis indicates that the baseline model structure is to be modified at sub-daily time steps to warrant the consistency and realism of the modelled fluxes. For the baseline model improvement, particular attention is devoted to the interception model component, whose output flux showed the strongest sensitivity to modelling time step. The dependency of the optimal model complexity on time step is also analysed. References: Perrin, C., Michel, C., Andréassian, V., 2003. Improvement of a parsimonious model for streamflow simulation. Journal of Hydrology, 279(1-4): 275-289. DOI:10.1016/S0022-1694(03)00225-7

Representation and Structure in Connectionist Models

DTIC Science & Technology

1989-08-01

among those who are actively exploring the to wonder how these models might differ topic (cf. Dolan & Dyer, 1987; Dolan & from traditional theories , and...because one of the critical ways in which cognitive theories may differ is in the Elman Representation & Structure some of the specific questions raised...that whereas Classi- atomistic or can they possess internal struc- cal theories (e.g., the Language of Thought, ture? Can that structure be used to

Structural equation modeling of the effects of racism, LGBTQ discrimination, and internalized oppression on illicit drug use in LGBTQ people of color.

PubMed

Drazdowski, Tess K; Perrin, Paul B; Trujillo, Michael; Sutter, Megan; Benotsch, Eric G; Snipes, Daniel J

2016-02-01

Experiences with lesbian, gay, bisexual, transgender, or queer (LGBTQ) discrimination and racism have both been associated with mental health problems and illicit drug use. However, the cumulative effects of both forms of discrimination--and resulting internalized oppression--on illicit drug use in LGBTQ people of color (POC) has not been examined in the research literature. Using online questionnaires, this study collected self-report data from 200 LGBTQ POC about their experiences with racism, LGBTQ discrimination, internalized racism, internalized LGBTQ discrimination, and illicit drug use. Two structural equation models yielded adequate fit indices in which experiences with racism and LGBTQ discrimination led to more internalized oppression, which then led to greater illicit drug use magnitude. LGBTQ discrimination was directly related to increased internalized oppression, which was positively associated with illicit drug use magnitude; the relationship between LGBTQ discrimination and illicit drug use magnitude was mediated by internalized oppression in both models. However, racism and the interaction between racism and LGBTQ discrimination did not show valid direct effects on internalized oppression or indirect effects on illicit drug use magnitude. LGBTQ POC can be the targets of both racism and LGBTQ discrimination, although the current study found that the most psychologically damaging effects may come from LGBTQ discrimination. Interventions meant to decrease or prevent illicit drug use in LGBTQ POC may benefit from helping participants examine the links among LGBTQ discrimination, internalized oppression, and illicit drug use as a coping strategy, focusing on substituting more adaptive coping. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Predicting Future Capabilities of the People’s Liberation Army Air Forces of China

DTIC Science & Technology

2010-04-01

are important—offensive realism and defensive realism. The author will first discuss the origins of realism in international relations theory ... neoclassical realism. First, the international system is one of anarchy. There is no structural model to regulate international behavior among independent...of Relative Gains in International Politics,” The Journal of Conflict Resolution 46, no. 3 (Jun., 2002): 394. 6 Kenneth N. Waltz, Theory of

Fate and Contribution of Internal Wave-Forced Barnacle Settlers to Community Structure in Northern Baja California, a Year after Settlement

NASA Astrophysics Data System (ADS)

Lievana, A.; Ladah, L. B.; Lavin, M. F.; Filonov, A. E.; Tapia, F. J.; Leichter, J.; Valencia Gasti, J. A.

2016-02-01

Physical transport processes, such as nonlinear internal waves, operating within the coastal ocean of Baja California, Mexico, are diverse, variable and operate on a variety of temporal and spatial scales. Understanding the influence of nonlinear internal waves, in part responsible for the exchange of water properties between coastal and offshore environments, on the structure of intertidal communities is important for the generation of working ecological models. The relationship between the supply of ecological subsidies associated with physical transport processes that operate on relatively short spatial and temporal scales, such as the internal tide, and intertidal community structure must be understood as processes that operate on distinct spatial and temporal scales may be prone to react uniquely as the climate changes. We designed an experiment to quantify recruitment and adult survivorship of Chthamalus sp. whose settlement was associated with internal wave activity in the nearby ocean and found that the number of settlers was a robust predictor of the number of adults observed, indicating that post-settlement processes such as competition and predation are not likely to significantly affect the structure of the intertidal barnacle community resulting from internal-wave forced settlement.

Bright-field electron tomography of individual inorganic fullerene-like structures.

PubMed

Bar Sadan, Maya; Wolf, Sharon G; Houben, Lothar

2010-03-01

Nanotubes and fullerene-like nanoparticles of various inorganic layered compounds have been studied extensively in recent years. Their characterisation on the atomic scale has proven essential for progress in synthesis as well as for the theoretical modelling of their physical properties. We show that with electron tomography it is possible to achieve a reliable reconstruction of the 3D structure of nested WS(2) or MoS(2) fullerene-like and nanotube structures with sub-nanometre resolution using electron microscopes that are not aberration-corrected. Model-based simulations were used to identify imaging parameters, under which structural features such as the shell structure can be retained in the tomogram reconstructed from bright-field micrographs. The isolation of a particle out of an agglomerate for the analysis of a single structure and its interconnection with other particles is facilitated through the tomograms. The internal structure of the layers within the particle alongside the shape and content of its internal void are reconstructed. The tomographic reconstruction yields insights regarding the growth process as well as structural defects, such as non-continuous layers, which relate to the lubrication properties.

Attributional style as a mediator between parental abuse risk and child internalizing symptomatology.

PubMed

Rodriguez, Christina M

2006-05-01

This study examined a model wherein children's attributional style mediates the relationship between parental physical child-abuse risk and children's internalizing problems. Using structural equation modeling, three indices of abuse risk were selected (child abuse potential, physical discipline use, and dysfunctional parenting style) and two indices of children's internalizing problems (depression and anxiety). The sample included 75 parent-child dyads, in which parents reported on their abuse risk and children independently completed measures of depressive and anxious symptomatology and a measure on their attributional style. Findings supported the model that children's attributional style for positive events (but not negative events) partially mediated the relationship between abuse risk and internalizing symptoms, with significant direct and indirect effects of abuse risk on internalizing symptomatology. Future directions to continue evaluating additional mediators and other possible contextual variables are discussed.

Three layer functional model and energy exchange concept of aging process

PubMed Central

Mihajlovic, William

2006-01-01

Relying on a certain degree of abstraction, we can propose that no particular distinction exists between animate or living matter and inanimate matter. While focusing attention on some specifics, the dividing line between the two can be drawn. The most apparent distinction is in the level of structural and functional organization with the dissimilar streams of ‘energy flow’ between the observed entity and the surrounding environment. In essence, living matter is created from inanimate matter which is organized to contain internal intense energy processes and maintain lower intensity energy exchange processes with the environment. Taking internal and external energy processes into account, we contend in this paper that living matter can be referred to as matter of dissipative structure, with this structure assumed to be a common quality of all living creatures and living matter in general. Interruption of internal energy conversion processes and terminating the controlled energy exchange with the environment leads to degeneration of dissipative structure and reduction of the same to inanimate matter, (gas, liquid and/or solid inanimate substances), and ultimately what can be called ‘death.’ This concept of what we call dissipative nature can be extended from living organisms to social groups of animals, to mankind. An analogy based on the organization of matter provides a basis for a functional model of living entities. The models relies on the parallels among the three central structures of any cell (nucleus, cytoplasm and outer membrane) and the human body (central organs, body fluids along with the connective tissues, and external skin integument). This three-part structural organization may be observed almost universally in nature. It can be observed from the atomic structure to the planetary and intergalactic organizations. This similarity is corroborated by the membrane theory applied to living organisms. According to the energy nature of living matter and the proposed functional model, the decreased integrity of a human body's external envelope membrane is a first cause of the structural degradation and aging of the entire organism. The aging process than progresses externally to internally, as in single cell organisms, suggesting that much of the efforts towards the restoration and maintenance of the mechanisms responsible for structural development should be focused accordingly, on the membrane, i.e., the skin. Numerous reports indicate that all parts of the human body, like: bones, blood with blood vessels, muscles, skin, and so on, have some ability for restoration. Therefore, actual revival of not only aging tissue of the human body's membrane, but the entire human body enclosed within, with all internal organs, might be expected. We assess several aging theories within the context of our model and provide suggestions on how to activate the body's own anti-aging mechanisms and increase longevity. This paper presents some analogies and some distinctions that exist between the living dissipative structure matter and inanimate matter, discusses the aging process and proposes certain aging reversal solutions. PMID:23598683

Role of cerebellum in learning postural tasks.

PubMed

Ioffe, M E; Chernikova, L A; Ustinova, K I

2007-01-01

For a long time, the cerebellum has been known to be a structure related to posture and equilibrium control. According to the anatomic structure of inputs and internal structure of the cerebellum, its role in learning was theoretically reasoned and experimentally proved. The hypothesis of an inverse internal model based on feedback-error learning mechanism combines feedforward control by the cerebellum and feedback control by the cerebral motor cortex. The cerebellar cortex is suggested to acquire internal models of the body and objects in the external world. During learning of a new tool the motor cortex receives feedback from the realized movement while the cerebellum produces only feedforward command. To realize a desired movement without feedback of the realized movement, the cerebellum needs to form an inverse model of the hand/arm system. This suggestion was supported by FMRi data. The role of cerebellum in learning new postural tasks mainly concerns reorganization of natural synergies. A learned postural pattern in dogs has been shown to be disturbed after lesions of the cerebral motor cortex or cerebellar nuclei. In humans, learning voluntary control of center of pressure position is greatly disturbed after cerebellar lesions. However, motor cortex and basal ganglia are also involved in the feedback learning postural tasks.

Clues to Ceres' Internal Structure

NASA Image and Video Library

2017-10-26

This frame from an animation shows Ceres as seen by NASA's Dawn spacecraft from its high-altitude mapping orbit at 913 miles (1,470 kilometers) above the surface. The colorful map overlaid at right shows variations in Ceres' gravity field measured by Dawn, and gives scientists hints about the dwarf planet's internal structure. Red colors indicate more positive values, corresponding to a stronger gravitational pull than expected, compared to scientists' pre-Dawn model of Ceres' internal structure; blue colors indicate more negative values, corresponding to a weaker gravitational pull. The animation was created by projecting a map of Ceres onto a rotating sphere. The image scale is about 450 feet (140 meters) per pixel. The animations are available at https://photojournal.jpl.nasa.gov/catalog/PIA22083

Real-time subject-specific monitoring of internal deformations and stresses in the soft tissues of the foot: a new approach in gait analysis.

PubMed

Yarnitzky, G; Yizhar, Z; Gefen, A

2006-01-01

No technology is presently available to provide real-time information on internal deformations and stresses in plantar soft tissues of individuals during evaluation of the gait pattern. Because internal deformations and stresses in the plantar pad are critical factors in foot injuries such as diabetic foot ulceration, this severely limits evaluation of patients. To allow such real-time subject-specific analysis, we developed a hierarchal modeling system which integrates a two-dimensional gross structural model of the foot (high-order model) with local finite element (FE) models of the plantar tissue padding the calcaneus and medial metatarsal heads (low-order models). The high-order whole-foot model provides real-time analytical evaluations of the time-dependent plantar fascia tensile forces during the stance phase. These force evaluations are transferred, together with foot-shoe local reaction forces, also measured in real time (under the calcaneus, medial metatarsals and hallux), to the low-order FE models of the plantar pad, where they serve as boundary conditions for analyses of local deformations and stresses in the plantar pad. After careful verification of our custom-made FE solver and of our foot model system with respect to previous literature and against experimental results from a synthetic foot phantom, we conducted human studies in which plantar tissue loading was evaluated in real time during treadmill gait in healthy individuals (N = 4). We concluded that internal deformations and stresses in the plantar pad during gait cannot be predicted from merely measuring the foot-shoe force reactions. Internal loading of the plantar pad is constituted by a complex interaction between the anatomical structure and mechanical behavior of the foot skeleton and soft tissues, the body characteristics, the gait pattern and footwear. Real-time FE monitoring of internal deformations and stresses in the plantar pad is therefore required to identify elevated deformation/stress exposures toward utilizing it in gait laboratories to protect feet that are susceptible to injury.

Nonlinear model predictive control for chemical looping process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joshi, Abhinaya; Lei, Hao; Lou, Xinsheng

A control system for optimizing a chemical looping ("CL") plant includes a reduced order mathematical model ("ROM") that is designed by eliminating mathematical terms that have minimal effect on the outcome. A non-linear optimizer provides various inputs to the ROM and monitors the outputs to determine the optimum inputs that are then provided to the CL plant. An estimator estimates the values of various internal state variables of the CL plant. The system has one structure adapted to control a CL plant that only provides pressure measurements in the CL loops A and B, a second structure adapted to amore » CL plant that provides pressure measurements and solid levels in both loops A, and B, and a third structure adapted to control a CL plant that provides full information on internal state variables. A final structure provides a neural network NMPC controller to control operation of loops A and B.« less

The Internalizing and Externalizing Structure of Psychiatric Comorbidity in Combat Veterans

PubMed Central

Miller, Mark W.; Fogler, Jason M.; Wolf, Erika J.; Kaloupek, Danny G.; Keane, Terence M.

2013-01-01

This study examined the latent structure of psychiatric disorders in a sample with a high prevalence of PTSD. A series of confirmatory factor analyses tested competing models for the covariation between SCID diagnoses among 1,325 Vietnam veterans. The best fitting solution was a three-factor model that included two correlated internalizing factors: anxious-misery, defined by PTSD and major depression, and fear, defined by panic disorder/agoraphobia and obsessive-compulsive disorder. The third factor, externalizing, was defined by antisocial personality disorder, alcohol abuse/dependence, and drug abuse/dependence. Both substance-related disorders also showed significant, albeit smaller, cross-loadings on the anxious-misery factor. These findings shed new light on the structure of psychiatric comorbidity in a treatment-seeking sample characterized by high rates of PTSD. PMID:18302181

Modeling the Magnetic and Thermal Structure of Active Regions: 1st Year 1st Semi-Annual Progress Report

NASA Technical Reports Server (NTRS)

Mikic, Zoran

2003-01-01

This report covers technical progress during the first six months of the first year of NASA SR&T contract "Modeling the Magnetic and Thermal Structure of Active Regions", NASW-03008, between NASA and Science Applications International Corporation, and covers the period January 14, 2003 to July 13, 2003. Under this contract SAIC has conducted research into theoretical modeling of the properties of active regions using the MHD model.

Bem Sex Role Inventory Validation in the International Mobility in Aging Study.

PubMed

Ahmed, Tamer; Vafaei, Afshin; Belanger, Emmanuelle; Phillips, Susan P; Zunzunegui, Maria-Victoria

2016-09-01

This study investigated the measurement structure of the Bem Sex Role Inventory (BSRI) with different factor analysis methods. Most previous studies on validity applied exploratory factor analysis (EFA) to examine the BSRI. We aimed to assess the psychometric properties and construct validity of the 12-item short-form BSRI in a sample administered to 1,995 older adults from wave 1 of the International Mobility in Aging Study (IMIAS). We used Cronbach's alpha to assess internal consistency reliability and confirmatory factor analysis (CFA) to assess psychometric properties. EFA revealed a three-factor model, further confirmed by CFA and compared with the original two-factor structure model. Results revealed that a two-factor solution (instrumentality-expressiveness) has satisfactory construct validity and superior fit to data compared to the three-factor solution. The two-factor solution confirms expected gender differences in older adults. The 12-item BSRI provides a brief, psychometrically sound, and reliable instrument in international samples of older adults.

Fluid Analysis and Improved Structure of an ATEG Heat Exchanger Based on Computational Fluid Dynamics

NASA Astrophysics Data System (ADS)

Tang, Z. B.; Deng, Y. D.; Su, C. Q.; Yuan, X. H.

2015-06-01

In this study, a numerical model has been employed to analyze the internal flow field distribution in a heat exchanger applied for an automotive thermoelectric generator based on computational fluid dynamics. The model simulates the influence of factors relevant to the heat exchanger, including the automotive waste heat mass flow velocity, temperature, internal fins, and back pressure. The result is in good agreement with experimental test data. Sensitivity analysis of the inlet parameters shows that increase of the exhaust velocity, compared with the inlet temperature, makes little contribution (0.1 versus 0.19) to the heat transfer but results in a detrimental back pressure increase (0.69 versus 0.21). A configuration equipped with internal fins is proved to offer better thermal performance compared with that without fins. Finally, based on an attempt to improve the internal flow field, a more rational structure is obtained, offering a more homogeneous temperature distribution, higher average heat transfer coefficient, and lower back pressure.

Langevin Equation for DNA Dynamics

NASA Astrophysics Data System (ADS)

Grych, David; Copperman, Jeremy; Guenza, Marina

Under physiological conditions, DNA oligomers can contain well-ordered helical regions and also flexible single-stranded regions. We describe the site-specific motion of DNA with a modified Rouse-Zimm Langevin equation formalism that describes DNA as a coarse-grained polymeric chain with global structure and local flexibility. The approach has successfully described the protein dynamics in solution and has been extended to nucleic acids. Our approach provides diffusive mode analytical solutions for the dynamics of global rotational diffusion and internal motion. The internal DNA dynamics present a rich energy landscape that accounts for an interior where hydrogen bonds and base-stacking determine structure and experience limited solvent exposure. We have implemented several models incorporating different coarse-grained sites with anisotropic rotation, energy barrier crossing, and local friction coefficients that include a unique internal viscosity and our models reproduce dynamics predicted by atomistic simulations. The models reproduce bond autocorrelation along the sequence as compared to that directly calculated from atomistic molecular dynamics simulations. The Langevin equation approach captures the essence of DNA dynamics without a cumbersome atomistic representation.

PREFACE: International Conference on Structural Nano Composites (NANOSTRUC 2012)

NASA Astrophysics Data System (ADS)

Njuguna, James

2012-09-01

Dear Colleagues It is a great pleasure to welcome you to NanoStruc2012 at Cranfield University. The purpose of the 2012 International Conference on Structural Nano Composites (NanoStruc2012) is to promote activities in various areas of materials and structures by providing a forum for exchange of ideas, presentation of technical achievements and discussion of future directions. NanoStruc brings together an international community of experts to discuss the state-of-the-art, new research results, perspectives of future developments, and innovative applications relevant to structural materials, engineering structures, nanocomposites, modelling and simulations, and their related application areas. The conference is split in 7 panel sessions, Metallic Nanocomposites and Coatings, Silica based Nanocomposites, safty of Nanomaterials, Carboin based Nanocomposites, Multscale Modelling, Bio materials and Application of Nanomaterials. All accepted Papers will be published in the IOP Conference Series: Materials Science and Engineering (MSE), and included in the NanoStruc online digital library. The abstracts will be indexed in Scopus, Compedex, Inspec, INIS (International Nuclear Information System), Chemical Abstracts, NASA Astrophysics Data System and Polymer Library. Before ending this message, I would like to acknowledge the hard work, professional skills and efficiency of the team which ensured the general organisation. As a conclusion, I would like to Welcome you to the Nanostruc2012 and wish you a stimulating Conference and a wonderful time. On behalf of the scientific committee, Signature James Njuguna Conference Chair The PDF of this preface also contains committee listings and associates logos.

Dendrite Model

NASA Technical Reports Server (NTRS)

1999-01-01

Dr. Donald Gilles, the Discipline Scientist for Materials Science in NASA's Microgravity Materials Science and Applications Department, demonstrates to Carl Dohrman a model of dendrites, the branch-like structures found in many metals and alloys. Dohrman was recently selected by the American Society for Metals International as their 1999 ASM International Foundation National Merit Scholar. The University of Illinois at Urbana-Champaign freshman recently toured NASA's materials science facilities at the Marshall Space Flight Center.

The advising alliance for international and domestic graduate students: Measurement invariance and implications for academic stress.

PubMed

Rice, Kenneth G; Suh, Hanna; Yang, Xiaohui; Choe, Elise; Davis, Don E

2016-04-01

We expanded the focus of a prior study of international graduate student advising relationships (Rice et al., 2009) to examine advising experiences of both international and domestic students. International (n = 434) and domestic (n = 387) students completed the Advisory Working Alliance Inventory (AWAI-S; Schlosser & Gelso, 2001) and measures of advising experiences, perceived academic stress, and desire to change advisor. Measurement invariance analyses suggested that a 23-item AWAI-S showed support for scalar invariance. A bifactor structure showed superior fit to the 3-factor model or a second-order factor model for the AWAI-S. International and domestic graduate students did not differ in ratings of general alliance, academic stress, or desire to change advisors. General alliance was strongly related to less academic stress and less desire to change advisors. International students who felt disrespected by their advisors were more likely to be academically stressed than domestic students. Structured mentoring experiences were associated with lower stress and less desire to change, and this effect was similar in both international and domestic students. Overall, results suggested that the current level of measurement, and possibly theory development, regarding the advisory alliance is good at identifying generic satisfaction but weaker at differentiating components of the alliance. (c) 2016 APA, all rights reserved).

Effect of DEXTRAN-graft-POLYACRYLAMIDE Internal Structure on Flocculation Process Parameters

NASA Astrophysics Data System (ADS)

Bezugla, T.; Kutsevol, N.; Shyichuk, A.; Ziolkowska, D.

2008-08-01

Dextran-graft-Polyacrylamide copolymers (D-g-PAA) of brush-like architecture were tested as flocculation aids in the model kaolin suspensions. Due to expanded conformation the D-g-PAA copolymers are more effective flocculants than individual PAA with close molecular mass. The internal structure of D-g-PAA copolymers which is determined by number and length of grafted PAA chains, the distance between grafts, etc., has the significant influence on flocculation behavior of such polymers.

Proposed Use of the Computer as a Tool to Aid Analysis of Properties of Materials in Fixators of Spine

PubMed Central

Santos, Antonio; Moreira, Fernando

2014-01-01

With objective of analyzing the mechanical behavior of the internal fixators of spine and of the bony structure, the pieces and the group were made (it structures bony x internal fixator) with the aid a software of solid modeling. The materials used in the rehearsals had been the titanium, now in the market and a castor oil polyurethane destined to the development of you implant bony. PMID:24825938

Numerical Simulation of Internal Waves in the Andaman Sea

NASA Astrophysics Data System (ADS)

Mohanty, Sachiko; Devendra Rao, Ambarukhana

2017-04-01

The interactions of barotropic tides with irregular bottom topography generate internal waves with high amplitude known as large-amplitude internal waves (LAIW) in the Andaman Sea. These waves are an important phenomena in the ocean due to their influence on the density structure and energy transfer into the region. These waves are also important in submarine acoustics, underwater navigation, offshore structures, ocean mixing, biogeochemical processes, etc. over the shelf-slope region. In the present study, energetics analysis of M2 internal tides over the Andaman Sea is carried out in detail by using a three-dimensional MIT general circulation ocean model (MITgcm). In-situ observations of temperature, conductivity and currents with high temporal resolution are used to validate the model simulations. From the spectral energy estimate of density, it is found that the peak estimate is associated with the semi-diurnal frequency at all the depths in both observations and model simulations. The baroclinic velocity characteristics, suggests that a multi-mode features of baroclinic tides are present at the buoy location. To understand the generation and propagation of internal tides over this region, energy flux and barotropic-to-baroclinic M2 tidal energy conversion rates are examined. The model simulation suggests that the internal tide is generated at multiple sites and propagate off of their respective generation sources. Most of the energy propagation in the Andaman Sea follows the 1000m isobath. The maximum horizontal kinetic energy follows the energy flux pattern over the domain and the available potential energy is found to be maximum in the north of the Andaman Sea.

Work-Family Balance and Psychosocial Adjustment of Married International Students

ERIC Educational Resources Information Center

Bulgan, Gökçe; Çiftçi, Ayse

2018-01-01

The authors investigated how work-family balance mediated the relationship between personality traits, gender roles, social support, and psychosocial adjustment. Data were collected from 243 married international graduate students (MIGSs) studying in the United States. Results of structural equation modeling indicated that personality traits…

Internal structure of mushroom-shaped salt diapirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-01-01

This book focuses on the dynamics and kinematics of salt diapirs with crestal bulbs shaped like a mushroom, one of the most complex types of diapirs, as interpreted by experimental modeling and from naturally occurring examples. Direct, practical applications of this research include use in the evaluation of salt domes as repositories for radioactive waste, in the exploration and production of salt, potash, and sulfur, and in the search for subtle hydrocarbon traps. The authors conducted 8 centrifuge experiments, which produced more than 100 model diapirs. These experiments were dynamically scaled to U.S. Gulf Coast salt domes, but the qualitativemore » results are also relevant to salt diapirs in other provinces and to granitoid diapirs penetrating metamorphic crust. The centrifuged domes grew under overburdens of constant thickness or under aggrading and prograding overburdens, a new experimental approach. Results indicate that external mushroom structure results from toroidal circulation of buoyant source and immediate cover having similar effective viscosities, whereas internal structure is produced by toroidal circulation confined within the diapir. The internal diapir structure elucidates the mechanics of emplacement and indicates whether an external mushroom shape can be expected and sought by further exploration.« less

Structural variations of single and tandem mismatches in RNA duplexes: a joint MD simulation and crystal structure database analysis.

PubMed

Halder, Sukanya; Bhattacharyya, Dhananjay

2012-10-04

Internal loops within RNA duplex regions are formed by single or tandem basepairing mismatches with flanking canonical Watson-Crick basepairs on both sides. They are the most common motif observed in RNA secondary structures and play integral functional and structural roles. In this report, we have studied the structural features of 1 × 1, 2 × 2, and 3 × 3 internal loops using all-atom molecular dynamics (MD) simulation technique with explicit solvent model. As MD simulation is intricately dependent on the choice of force-field and these are often rather approximate, we have used both the most popular force-fields for nucleic acids-CHARMM27 and AMBER94-for a comparative analysis. We find that tandem noncanonical basepairs forming 2 × 2 and 3 × 3 internal loops are considerably more stable than the single mismatches forming 1 × 1 internal loops, irrespective of the force field. We have also analyzed crystal structure database to study the conservation of these helical fragments in the corresponding sets of RNA structures. We observe that the nature of stability in MD simulations mimic their fluctuating natures in crystal data sets also, probably indicating reliable natures of both the force fields to reproduce experimental results. We also notice significant structural changes in the wobble G:U basepairs present in these double helical stretches, leading to a biphasic stability for these wobble pairs to release the deformational strains introduced by internal loops within duplex regions.

The dynamical environment of asteroid 21 Lutetia according to different internal models

NASA Astrophysics Data System (ADS)

Aljbaae, S.; Chanut, T. G. G.; Carruba, V.; Souchay, J.; Prado, A. F. B. A.; Amarante, A.

2017-01-01

One of the most accurate models currently used to represent the gravity field of irregular bodies is the polyhedral approach. In this model, the mass of the body is assumed to be homogeneous, which may not be true for a real object. The main goal of the this paper is to study the dynamical effects induced by three different internal structures (uniform, three- and four-layered) of asteroid (21) Lutetia, an object that recent results from space probe suggest being at least partially differentiated. The Mascon gravity approach used in the this work consists of dividing each tetrahedron into eight parts to calculate the gravitational field around the asteroid. The zero-velocity curves show that the greatest displacement of the equilibrium points occurs in the position of the E4 point for the four-layered structure and the smallest one occurs in the position of the E3 point for the three-layered structure. Moreover, stability against impact shows that the planar limit gets slightly closer to the body with the four-layered structure. We then investigated the stability of orbital motion in the equatorial plane of (21) Lutetia and propose numerical stability criteria to map the region of stable motions. Layered structures could stabilize orbits that were unstable in the homogeneous model.

Segmentation of risk structures for otologic surgery using the Probabilistic Active Shape Model (PASM)

NASA Astrophysics Data System (ADS)

Becker, Meike; Kirschner, Matthias; Sakas, Georgios

2014-03-01

Our research project investigates a multi-port approach for minimally-invasive otologic surgery. For planning such a surgery, an accurate segmentation of the risk structures is crucial. However, the segmentation of these risk structures is a challenging task: The anatomical structures are very small and some have a complex shape, low contrast and vary both in shape and appearance. Therefore, prior knowledge is needed which is why we apply model-based approaches. In the present work, we use the Probabilistic Active Shape Model (PASM), which is a more flexible and specific variant of the Active Shape Model (ASM), to segment the following risk structures: cochlea, semicircular canals, facial nerve, chorda tympani, ossicles, internal auditory canal, external auditory canal and internal carotid artery. For the evaluation we trained and tested the algorithm on 42 computed tomography data sets using leave-one-out tests. Visual assessment of the results shows in general a good agreement of manual and algorithmic segmentations. Further, we achieve a good Average Symmetric Surface Distance while the maximum error is comparatively large due to low contrast at start and end points. Last, we compare the PASM to the standard ASM and show that the PASM leads to a higher accuracy.

Three-and-a-half-factor model? The genetic and environmental structure of the CBCL/6-18 internalizing grouping.

PubMed

Franić, Sanja; Dolan, Conor V; Borsboom, Denny; van Beijsterveldt, Catherina E M; Boomsma, Dorret I

2014-05-01

In the present article, multivariate genetic item analyses were employed to address questions regarding the ontology and the genetic and environmental etiology of the Anxious/Depressed, Withdrawn, and Somatic Complaints syndrome dimensions of the Internalizing grouping of the Child Behavior Checklist/6-18 (CBCL/6-18). Using common and independent pathway genetic factor modeling, it was examined whether these syndrome dimensions can be ascribed a realist ontology. Subsequently, the structures of the genetic and environmental influences giving rise to the observed symptom covariation were examined. Maternal ratings of a population-based sample of 17,511 Dutch twins of mean age 7.4 (SD = 0.4) on the items of the Internalizing grouping of the Dutch CBCL/6-18 were analyzed. Applications of common and independent pathway modeling demonstrated that the Internalizing syndrome dimensions may be better understood as a composite of unconstrained genetic and environmental influences than as causally relevant entities generating the observed symptom covariation. Furthermore, the results indicate a common genetic basis for anxiety, depression, and withdrawn behavior, with the distinction between these syndromes being driven by the individual-specific environment. Implications for the substantive interpretation of these syndrome dimensions are discussed.

My Science Class and Expected Career Choices--A Structural Equation Model of Determinants Involving Abu Dhabi High School Students

ERIC Educational Resources Information Center

Badri, Masood; Alnuaimi, Ali; Mohaidat, Jihad; Al Rashedi, Asma; Yang, Guang; Al Mazroui, Karima

2016-01-01

Background: This study is about Abu Dhabi high school students' interest in science in different contexts. The survey was conducted in connection with the international project, the Relevance of Science Education (ROSE). The sample consists of 5650 students in public and private schools. A structural equation model (SEM) is developed to capture…

Variable structure control of nonlinear systems through simplified uncertain models

NASA Technical Reports Server (NTRS)

Sira-Ramirez, Hebertt

1986-01-01

A variable structure control approach is presented for the robust stabilization of feedback equivalent nonlinear systems whose proposed model lies in the same structural orbit of a linear system in Brunovsky's canonical form. An attempt to linearize exactly the nonlinear plant on the basis of the feedback control law derived for the available model results in a nonlinearly perturbed canonical system for the expanded class of possible equivalent control functions. Conservatism tends to grow as modeling errors become larger. In order to preserve the internal controllability structure of the plant, it is proposed that model simplification be carried out on the open-loop-transformed system. As an example, a controller is developed for a single link manipulator with an elastic joint.

Simulation on the internal structure of three-dimensional proximal tibia under different mechanical environments.

PubMed

Fang, Juan; Gong, He; Kong, Lingyan; Zhu, Dong

2013-12-20

Bone can adjust its morphological structure to adapt to the changes of mechanical environment, i.e. the bone structure change is related to mechanical loading. This implies that osteoarthritis may be closely associated with knee joint deformity. The purposes of this paper were to simulate the internal bone mineral density (BMD) change in three-dimensional (3D) proximal tibia under different mechanical environments, as well as to explore the relationship between mechanical environment and bone morphological abnormity. The right proximal tibia was scanned with CT to reconstruct a 3D proximal tibia model in MIMICS, then it was imported to finite element software ANSYS to establish 3D finite element model. The internal structure of 3D proximal tibia of young normal people was simulated using quantitative bone remodeling theory in combination with finite element method, then based on the changing pattern of joint contact force on the tibial plateau in valgus knees, the mechanical loading was changed, and the simulated normal tibia structure was used as initial structure to simulate the internal structure of 3D proximal tibia for old people with 6° valgus deformity. Four regions of interest (ROIs) were selected in the proximal tibia to quantitatively analyze BMD and compare with the clinical measurements. The simulation results showed that the BMD distribution in 3D proximal tibia was consistent with clinical measurements in normal knees and that in valgus knees was consistent with the measurement of patients with osteoarthritis in clinics. It is shown that the change of mechanical environment is the main cause for the change of subchondral bone structure, and being under abnormal mechanical environment for a long time may lead to osteoarthritis. Besides, the simulation method adopted in this paper can more accurately simulate the internal structure of 3D proximal tibia under different mechanical environments. It helps to better understand the mechanism of osteoarthritis and provides theoretical basis and computational method for the prevention and treatment of osteoarthritis. It can also serve as basis for further study on periprosthetic BMD changes after total knee arthroplasty, and provide a theoretical basis for optimization design of prosthesis.

Simulation on the internal structure of three-dimensional proximal tibia under different mechanical environments

PubMed Central

2013-01-01

Background Bone can adjust its morphological structure to adapt to the changes of mechanical environment, i.e. the bone structure change is related to mechanical loading. This implies that osteoarthritis may be closely associated with knee joint deformity. The purposes of this paper were to simulate the internal bone mineral density (BMD) change in three-dimensional (3D) proximal tibia under different mechanical environments, as well as to explore the relationship between mechanical environment and bone morphological abnormity. Methods The right proximal tibia was scanned with CT to reconstruct a 3D proximal tibia model in MIMICS, then it was imported to finite element software ANSYS to establish 3D finite element model. The internal structure of 3D proximal tibia of young normal people was simulated using quantitative bone remodeling theory in combination with finite element method, then based on the changing pattern of joint contact force on the tibial plateau in valgus knees, the mechanical loading was changed, and the simulated normal tibia structure was used as initial structure to simulate the internal structure of 3D proximal tibia for old people with 6° valgus deformity. Four regions of interest (ROIs) were selected in the proximal tibia to quantitatively analyze BMD and compare with the clinical measurements. Results The simulation results showed that the BMD distribution in 3D proximal tibia was consistent with clinical measurements in normal knees and that in valgus knees was consistent with the measurement of patients with osteoarthritis in clinics. Conclusions It is shown that the change of mechanical environment is the main cause for the change of subchondral bone structure, and being under abnormal mechanical environment for a long time may lead to osteoarthritis. Besides, the simulation method adopted in this paper can more accurately simulate the internal structure of 3D proximal tibia under different mechanical environments. It helps to better understand the mechanism of osteoarthritis and provides theoretical basis and computational method for the prevention and treatment of osteoarthritis. It can also serve as basis for further study on periprosthetic BMD changes after total knee arthroplasty, and provide a theoretical basis for optimization design of prosthesis. PMID:24359345

Which preparatory curriculum for the International Baccalaureate Diploma Programme is best? The challenge for international schools with regard to mathematics and science

NASA Astrophysics Data System (ADS)

Corlu, M. Sencer

2014-12-01

There are two mainstream curricula for international school students at the junior high level: the International Baccalaureate (IB) Middle Years Programme (MYP) and the Cambridge International General Certificate of Secondary Education (IGCSE). The former was developed in the mid-1990s and is currently being relaunched in a 21st-century approach. The latter programme of study was developed by University of Cambridge International Examinations in 1985 and has become popular in recent years among British domestic and international schools worldwide due to the clarity of its learning content. The prevailing uncertainty about which curriculum is best to prepare students for the IB Diploma Programme represents a challenge for international schools. The purpose of the current study is to develop a methodology through causal models which can explain the relationship between student performance in the IGCSE and the Diploma Programme with regard to mathematics and science. The data evaluated here consisted of external examination scores of students who attended a private international high school between the years 2005 and 2012. Two structural equation models were developed. The first model employed a maximum likelihood estimation, while the second model used a Bayesian estimation with a Markov Chain Monte Carlo method. Both models fit the data well. The evidence suggests that the IGCSE provides a good foundational preparation for the Diploma Programme in mathematics and science.

Disorders without borders: current and future directions in the meta-structure of mental disorders.

PubMed

Carragher, Natacha; Krueger, Robert F; Eaton, Nicholas R; Slade, Tim

2015-03-01

Classification is the cornerstone of clinical diagnostic practice and research. However, the extant psychiatric classification systems are not well supported by research evidence. In particular, extensive comorbidity among putatively distinct disorders flags an urgent need for fundamental changes in how we conceptualize psychopathology. Over the past decade, research has coalesced on an empirically based model that suggests many common mental disorders are structured according to two correlated latent dimensions: internalizing and externalizing. We review and discuss the development of a dimensional-spectrum model which organizes mental disorders in an empirically based manner. We also touch upon changes in the DSM-5 and put forward recommendations for future research endeavors. Our review highlights substantial empirical support for the empirically based internalizing-externalizing model of psychopathology, which provides a parsimonious means of addressing comorbidity. As future research goals, we suggest that the field would benefit from: expanding the meta-structure of psychopathology to include additional disorders, development of empirically based thresholds, inclusion of a developmental perspective, and intertwining genomic and neuroscience dimensions with the empirical structure of psychopathology.

Health Promotion Behavior of Chinese International Students in Korea Including Acculturation Factors: A Structural Equation Model.

PubMed

Kim, Sun Jung; Yoo, Il Young

2016-03-01

The purpose of this study was to explain the health promotion behavior of Chinese international students in Korea using a structural equation model including acculturation factors. A survey using self-administered questionnaires was employed. Data were collected from 272 Chinese students who have resided in Korea for longer than 6 months. The data were analyzed using structural equation modeling. The p value of final model is .31. The fitness parameters of the final model such as goodness of fit index, adjusted goodness of fit index, normed fit index, non-normed fit index, and comparative fit index were more than .95. Root mean square of residual and root mean square error of approximation also met the criteria. Self-esteem, perceived health status, acculturative stress and acculturation level had direct effects on health promotion behavior of the participants and the model explained 30.0% of variance. The Chinese students in Korea with higher self-esteem, perceived health status, acculturation level, and lower acculturative stress reported higher health promotion behavior. The findings can be applied to develop health promotion strategies for this population. Copyright © 2016. Published by Elsevier B.V.

Molecular dynamics modelling of mechanical properties of polymers for adaptive aerospace structures

NASA Astrophysics Data System (ADS)

Papanikolaou, Michail; Drikakis, Dimitris; Asproulis, Nikolaos

2015-02-01

The features of adaptive structures depend on the properties of the supporting materials. For example, morphing wing structures require wing skin materials, such as rubbers that can withstand the forces imposed by the internal mechanism while maintaining the required aerodynamic properties of the aircraft. In this study, Molecular Dynamics and Minimization simulations are being used to establish well-equilibrated models of Ethylene-Propylene-Diene Monomer (EPDM) elastomer systems and investigate their mechanical properties.

The numerics of hydrostatic structured-grid coastal ocean models: State of the art and future perspectives

NASA Astrophysics Data System (ADS)

Klingbeil, Knut; Lemarié, Florian; Debreu, Laurent; Burchard, Hans

2018-05-01

The state of the art of the numerics of hydrostatic structured-grid coastal ocean models is reviewed here. First, some fundamental differences in the hydrodynamics of the coastal ocean, such as the large surface elevation variation compared to the mean water depth, are contrasted against large scale ocean dynamics. Then the hydrodynamic equations as they are used in coastal ocean models as well as in large scale ocean models are presented, including parameterisations for turbulent transports. As steps towards discretisation, coordinate transformations and spatial discretisations based on a finite-volume approach are discussed with focus on the specific requirements for coastal ocean models. As in large scale ocean models, splitting of internal and external modes is essential also for coastal ocean models, but specific care is needed when drying & flooding of intertidal flats is included. As one obvious characteristic of coastal ocean models, open boundaries occur and need to be treated in a way that correct model forcing from outside is transmitted to the model domain without reflecting waves from the inside. Here, also new developments in two-way nesting are presented. Single processes such as internal inertia-gravity waves, advection and turbulence closure models are discussed with focus on the coastal scales. Some overview on existing hydrostatic structured-grid coastal ocean models is given, including their extensions towards non-hydrostatic models. Finally, an outlook on future perspectives is made.

Feasibility of using piezoelectric actuators to control launch vehicle acoustics and structural vibrations

NASA Astrophysics Data System (ADS)

Niezrecki, Christopher; Cudney, Harley H.

2000-06-01

Future launch vehicle payload fairings will be manufactured form advanced lightweight composite materials. The loss of distributed mass causes a significant increase in the internal acoustic environment, causing a severe threat to the payload. Using piezoelectric actuators to control the fairing vibration and the internal acoustic environment has been proposed. To help determine the acoustic control authority of piezoelectric actuators mounted on a rocket fairing, the internal acoustic response created by the actuators needs to be determined. In this work, the internal acoustic response of a closed simply-supported (SS) cylinder actuated by piezoelectric (PZT) actuators is determined using a n impedance model for the actuator and boundary element analysis. The experimentally validated model is used to extrapolate results for a SS cylinder that emulates a Minotaur payload fairing. The internal cylinder acoustic levels are investigated for PZT actuation between 35 and 400 Hz. Significant reductions in the structural response due to increased damping do not equate to similar reductions in the acoustic SPLs for the cylinder. The sound levels at the acoustic resonant frequencies are essentially unaffected by the significant increase in structural damping while the acoustic level sat the structural resonant frequencies are mildly reduced. The interior acoustic response of the cylinder is dominated by the acoustic modes and therefore significant reductions in the overall interior acoustic levels will not be achieved if only the structural resonances are controlled. As the actuation frequency is reduced, the number of actuators required to generate acoustic levels commensurate to that found in the fairing increases to impractical values. Below approximately 100 Hz, the current demands reach levels that are extremely difficult to achieve with a practical system. The results of this work imply that PZT actuators do not have the authority to control the payload fairing internal acoustics below approximately 100 Hz.

Tuning algorithms for fractional order internal model controllers for time delay processes

NASA Astrophysics Data System (ADS)

Muresan, Cristina I.; Dutta, Abhishek; Dulf, Eva H.; Pinar, Zehra; Maxim, Anca; Ionescu, Clara M.

2016-03-01

This paper presents two tuning algorithms for fractional-order internal model control (IMC) controllers for time delay processes. The two tuning algorithms are based on two specific closed-loop control configurations: the IMC control structure and the Smith predictor structure. In the latter, the equivalency between IMC and Smith predictor control structures is used to tune a fractional-order IMC controller as the primary controller of the Smith predictor structure. Fractional-order IMC controllers are designed in both cases in order to enhance the closed-loop performance and robustness of classical integer order IMC controllers. The tuning procedures are exemplified for both single-input-single-output as well as multivariable processes, described by first-order and second-order transfer functions with time delays. Different numerical examples are provided, including a general multivariable time delay process. Integer order IMC controllers are designed in each case, as well as fractional-order IMC controllers. The simulation results show that the proposed fractional-order IMC controller ensures an increased robustness to modelling uncertainties. Experimental results are also provided, for the design of a multivariable fractional-order IMC controller in a Smith predictor structure for a quadruple-tank system.

Foundational model of structural connectivity in the nervous system with a schema for wiring diagrams, connectome, and basic plan architecture

PubMed Central

Swanson, Larry W.; Bota, Mihail

2010-01-01

The nervous system is a biological computer integrating the body's reflex and voluntary environmental interactions (behavior) with a relatively constant internal state (homeostasis)—promoting survival of the individual and species. The wiring diagram of the nervous system's structural connectivity provides an obligatory foundational model for understanding functional localization at molecular, cellular, systems, and behavioral organization levels. This paper provides a high-level, downwardly extendible, conceptual framework—like a compass and map—for describing and exploring in neuroinformatics systems (such as our Brain Architecture Knowledge Management System) the structural architecture of the nervous system's basic wiring diagram. For this, the Foundational Model of Connectivity's universe of discourse is the structural architecture of nervous system connectivity in all animals at all resolutions, and the model includes two key elements—a set of basic principles and an internally consistent set of concepts (defined vocabulary of standard terms)—arranged in an explicitly defined schema (set of relationships between concepts) allowing automatic inferences. In addition, rules and procedures for creating and modifying the foundational model are considered. Controlled vocabularies with broad community support typically are managed by standing committees of experts that create and refine boundary conditions, and a set of rules that are available on the Web. PMID:21078980

Investigation of impact phenomena on the marine structures: Part II - Internal energy of the steel structure applied by selected materials in the ship-ship collision incidents

NASA Astrophysics Data System (ADS)

Prabowo, A. R.; Baek, S. J.; Lee, S. G.; Bae, D. M.; Sohn, J. M.

2018-01-01

Phenomena of impact loads on the marine structures has attracted attention to be predicted regarding its influences to structural damage. This part demands sustainable analysis and observation as tendency may vary from one to others since impact involves various scenario models and the structure itself experiences continuous development. Investigation of the damage extent can be conducted by observation on the energy behaviour during two entities involve in a contact. This study aimed to perform numerical investigation to predict structural damage by assessing absorbed strain energy represented by the internal energy during a series of ship collisions. The collision target in ship-ship interactions were determined on the single and double hulls part of a passenger ship. Tendency of the internal energy by the steel structures was summarized, and verification was presented by several crashworthiness criteria. It was found that steel structures applied by the material grades A and B produced different tendencies compared to the material grades D and E. Effect of the structural arrangement to structural responses in terms of strain and stress indicated that the single hull presented contour expansion mainly on the longitudinal directions.

Nonlinearity measure and internal model control based linearization in anti-windup design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perev, Kamen

2013-12-18

This paper considers the problem of internal model control based linearization in anti-windup design. The nonlinearity measure concept is used for quantifying the control system degree of nonlinearity. The linearizing effect of a modified internal model control structure is presented by comparing the nonlinearity measures of the open-loop and closed-loop systems. It is shown that the linearization properties are improved by increasing the control system local feedback gain. However, it is emphasized that at the same time the stability of the system deteriorates. The conflicting goals of stability and linearization are resolved by solving the design problem in different frequencymore » ranges.« less

Adolescents' Emotion Regulation Strategies, Self-Concept, and Internalizing Problems

ERIC Educational Resources Information Center

Hsieh, Manying; Stright, Anne Dopkins

2012-01-01

This study examined the relationships among adolescents' emotion regulation strategies (suppression and cognitive reappraisal), self-concept, and internalizing problems using structural equation modeling. The sample consisted of 438 early adolescents (13 to 15 years old) in Taiwan, including 215 boys and 223 girls. For both boys and girls,…

Student Satisfaction with an Innovative Internship

ERIC Educational Resources Information Center

Petrila, Ann; Fireman, Orah; Fitzpatrick, Leslie Schnoll; Hodas, Robyn Wertheimer; Taussig, Heather N.

2015-01-01

This article describes an internship program designed specifically to meet graduate students' training needs within the context of their work in a prevention program for children in foster care. An internship based on a strong model of intern recruitment and supervision, structured inclusion of interns in a supportive agency culture, a…

Concealing Concealment: The Mediating Role of Internalized Heterosexism in Psychological Distress Among Lesbian, Gay, and Bisexual Older Adults

PubMed Central

Hoy-Ellis, Charles P.

2016-01-01

Recent population-based studies indicate that sexual minorities aged 50 and older experience significantly higher rates of psychological distress than their heterosexual age-peers. The minority stress model has been useful in explaining disparately high rates of psychological distress among younger sexual minorities. The purpose of this study is to test a hypothesized structural relationship between two minority stressors—internalized heterosexism and concealment of sexual orientation—and consequent psychological distress among a sample of 2,349 lesbian, gay, and bisexual adults aged 50 to 95 years old. Structural equation modeling indicates that concealment has a nonsignificant direct effect on psychological distress but a significant indirect effect that is mediated through internalized heterosexism; the effect of concealment is itself concealed. This may explain divergent results regarding the role of concealment in psychological distress in other studies, and the implications will be discussed. PMID:26322654

Towards Humanlike Social Touch for Prosthetics and Sociable Robotics: Three-Dimensional Finite Element Simulations of Synthetic Finger Phalanges

NASA Astrophysics Data System (ADS)

Cabibihan, John-John; Ge, Shuzhi Sam

Synthetic skins with humanlike characteristic would make it possible to address some of the psychosocial requirements of prosthetic hands as well as the safety and acceptance issues in social robotics. This paper describes the development of three-dimensional finite element models of synthetic finger phalanges. With the aim of duplicating the skin compliance of human finger phalanges, the model was used to investigate the effects of (i) introducing open pockets in the internal structure and (ii) combining different materials as external and internal layers. The results show that having pockets in the internal structure of the design can increase the skin compliance of the synthetic phalanges and make it comparable with the human counterpart. Moreover, having different layers can be used to satisfy skin compliance and other design requirements such as wear and tear.

Internalized Homophobia as a Partial Mediator between Homophobic Bullying and Self-Esteem among Sexual Minority Youths in Quebec (Canada)

PubMed Central

Blais, Martin; Gervais, Jesse; Hébert, Martine

2016-01-01

Verbal/psychological homophobic bullying is widespread among sexual minority youths. Homophobic bullying has been associated with both high internalized homophobia and low self-esteem. The objectives were to document verbal/psychological homophobic bullying among sexual minority youths and to model the relationships between homophobic bullying, internalized homophobia and self-esteem. Method: A community sample of 300 sexual minority youths aged 14 to 22 years old was used. A structural equations model was tested using a nonlinear, robust estimator implemented in Mplus. The model postulated that homophobic bullying impacts self-esteem both directly and indirectly, via internalized homophobia. Results: 60.7% of the sample reported at least on form of verbal/psychological homophobic bullying. The model explained 29% of the variance of self-esteem, 19.6% of the variance of internalized homophobia and 5.3% of the verbal/psychological homophobic bullying. The model suggests that the relationship between verbal/psychological homophobic bullying and self-esteem is partially mediated by internalized homophobia. Conclusion: Our results underscore the importance of initiatives to prevent homophobic bullying in order to prevent its negative effects on well-being of sexual minority youths. PMID:24714888

Internalized homophobia as a partial mediator between homophobic bullying and self-esteem among youths of sexual minorities in Quebec (Canada).

PubMed

Blais, Martin; Gervais, Jesse; Hébert, Martine

2014-03-01

Verbal/psychological homophobic bullying is widespread among youths of sexual minorities. Homophobic bullying has been associated with both high internalized homophobia and low self-esteem. The objectives were to document verbal/psychological homophobic bullying among youths of sexual minorities and model the relationships between homophobic bullying, internalized homophobia and self-esteem. A community sample of 300 youths of sexual minorities aged 14 to 22 years old was used. A structural equation model was tested using a nonlinear, robust estimator implemented in Mplus. The model postulated that homophobic bullying impacts self-esteem both directly and indirectly, via internalized homophobia. 60.7% of the sample reported at least one form of verbal/psychological homophobic bullying. The model explained 29% of the variance of self-esteem, 19.6% of the variance of internalized homophobia and 5.3% of the verbal/psychological homophobic bullying. The model suggests that the relationship between verbal/psychological homophobic bullying and self-esteem is partially mediated by internalized homophobia. The results underscore the importance of initiatives to prevent homophobic bullying in order to prevent its negative effects on the well-being of youths of sexual minorities.

Finite Element Based HWB Centerbody Structural Optimization and Weight Prediction

NASA Technical Reports Server (NTRS)

Gern, Frank H.

2012-01-01

This paper describes a scalable structural model suitable for Hybrid Wing Body (HWB) centerbody analysis and optimization. The geometry of the centerbody and primary wing structure is based on a Vehicle Sketch Pad (VSP) surface model of the aircraft and a FLOPS compatible parameterization of the centerbody. Structural analysis, optimization, and weight calculation are based on a Nastran finite element model of the primary HWB structural components, featuring centerbody, mid section, and outboard wing. Different centerbody designs like single bay or multi-bay options are analyzed and weight calculations are compared to current FLOPS results. For proper structural sizing and weight estimation, internal pressure and maneuver flight loads are applied. Results are presented for aerodynamic loads, deformations, and centerbody weight.

Impact of Soft Tissue Heterogeneity on Augmented Reality for Liver Surgery.

PubMed

Haouchine, Nazim; Cotin, Stephane; Peterlik, Igor; Dequidt, Jeremie; Lopez, Mario Sanz; Kerrien, Erwan; Berger, Marie-Odile

2015-05-01

This paper presents a method for real-time augmented reality of internal liver structures during minimally invasive hepatic surgery. Vessels and tumors computed from pre-operative CT scans can be overlaid onto the laparoscopic view for surgery guidance. Compared to current methods, our method is able to locate the in-depth positions of the tumors based on partial three-dimensional liver tissue motion using a real-time biomechanical model. This model permits to properly handle the motion of internal structures even in the case of anisotropic or heterogeneous tissues, as it is the case for the liver and many anatomical structures. Experimentations conducted on phantom liver permits to measure the accuracy of the augmentation while real-time augmentation on in vivo human liver during real surgery shows the benefits of such an approach for minimally invasive surgery.

TOWARDS REFINED USE OF TOXICITY DATA IN STATISTICALLY BASED SAR MODELS FOR DEVELOPMENTAL TOXICITY.

EPA Science Inventory

In 2003, an International Life Sciences Institute (ILSI) Working Group examined the potential of statistically based structure-activity relationship (SAR) models for use in screening environmental contaminants for possible developmental toxicants.

modeling lunar seisms in class

NASA Astrophysics Data System (ADS)

Blancou, Emmanuelle

2017-04-01

Students are taught that the internal structure of the Earth has been described by analyzing seismometer data collected at the surface of the Earth. With this in mind, a group of 17-years old students asked whether lunar seisms could be used to explore the internal structure of the Moon. Seismometers placed during Apollo 12, 14, 15 and 16 missions recorded many seismic events. The signals obtained on the Moon are different form those recorded on Earth and are due to meteorite impact, lunar tides and thermal variations. Students tried to model meteorite impacts and thermal moonquakes to determine whether they can be distinguished based on their seismic signature. To this aim, the impact of meteorites were modeled by a metallic ball falling in sand and thermal moonquakes were modeled by storing hydrates rocks on a freezer during a week and then upon a bain marie. Signal were collected in both conditions with microphones. Data showed distinctive feature depending on vibration origin.

A Three-dimensional Non-spherical Calculation Of The Rotationally Distorted Shape And Internal Structure Of A Model Of Jupiter With A Polytropic Index Of Unity

NASA Astrophysics Data System (ADS)

Zhang, Keke; Kong, D.; Schubert, G.; Anderson, J.

2012-10-01

An accurate calculation of the rotationally distorted shape and internal structure of Jupiter is required to understand the high-precision gravitational field that will be measured by the Juno spacecraft now on its way to Jupiter. We present a three-dimensional non-spherical numerical calculation of the shape and internal structure of a model of Jupiter with a polytropic index of unity. The calculation is based on a finite element method and accounts for the full effects of rotation. After validating the numerical approach against the asymptotic solution of Chandrasekhar (1933) that is valid only for a slowly rotating gaseous planet, we apply it to a model of Jupiter whose rapid rotation causes a significant departure from spherical geometry. The two-dimensional distribution of the density and the pressure within Jupiter is then determined via a hybrid inverse approach by matching the a priori unknown coefficient in the equation of state to the observed shape of Jupiter. After obtaining the two-dimensional distribution of Jupiter's density, we then compute the zonal gravity coefficients and the total mass from the non-spherical Jupiter model that takes full account of rotation-induced shape changes. Our non-spherical model with a polytrope of unit index is able to produce the known mass and zonal gravitational coefficients of Jupiter. Chandrasekhar, S. 1933, The equilibrium of distorted polytropes, MNRAS 93, 390

A NASTRAN Model of a Large Flexible Swing-Wing Bomber. Volume 1: NASTRAN Model Plane

NASA Technical Reports Server (NTRS)

Mock, W. D.

1982-01-01

A review was conducted of B-1 aircraft no. 2 (A/C-2) internal loads models to determine the minimum model complexity necessary to fulfill all of the airloads research study objectives. Typical model sizings were tabulated at selected vehicle locations, and scale layouts were prepared of the NASTRAN structural analysis model.

A selfsimilar behavior of the urban structure in the spatially inhomogeneous model

NASA Astrophysics Data System (ADS)

Echkina, E. Y.; Inovenkov, O. I.; Kostomarov, D. P.

2006-03-01

At present there is a strong tendency to use new methods for the description of the regional and spatial economy. In increasing frequency we consider that any economic activity is spatially dependent. The problem of the evolution of internal urban formation can be described with the exact supposition. So that is why we use partial derivative equations set with the appropriate boundary and initial conditions for the solving the problem of the urban evolution. Here we describe the model of urban population's density modification taking into account a modification of the housing quality. A program has been created which realizes difference method of mixed problem solution for population's density. For the wide class of coefficients it has been shown that the problem's solution “quickly forgets” the parts of the initial conditions and comes out to the intermediate asymptotic form, which nature depends only on the problem's operator. Actually it means that the urban structure does not depend on external circumstances and is formed by the internal structure of the model.

Testing theoretical models of subdwarf B stars using multicolor photometry

NASA Astrophysics Data System (ADS)

Reed, Mike; Baran, Andrzej; Ostensen, Roy; O'Toole, Simon

2012-08-01

Pulsating stars allow a direct investigation of their structure and evolutionary history from the evaluation of pulsation modes. However, the observed pulsation frequencies must first be identified with spherical harmonics (modes). For subdwarfs B (sdB) stars, such identifications using white light photometry currently have significant limitations. We intend to use multicolor photometry to identify pulsation modes and constrain structure models. We propose to observe the pulsating sdB star PG0154+182 (BI Ari) with our multicolor instrument GT Cam. Our observations will be compared with perturbative atmospheric models (BRUCE/KYLIE) to identify the pulsation modes. This is part of our NSF grant to obtain seismic tools to test structure and evolution models; constraining stellar parameters including total mass, envelope mass, internal composition discontinuities and internal rotation. During winter/spring 2012, we were allocated three runs on the 2.1 m to collect multicolor data on other promising pulsating subdwarf B stars as part of this work. Those runs were very successful, prompting our continued proposals. In addition, we will obtain 3-color data using MAIA on the Mercator Telescope (using guaranteed institutional time).

Solution structure of a GAAA tetraloop receptor RNA.

PubMed Central

Butcher, S E; Dieckmann, T; Feigon, J

1997-01-01

The GAAA tetraloop receptor is an 11-nucleotide RNA sequence that participates in the tertiary folding of a variety of large catalytic RNAs by providing a specific binding site for GAAA tetraloops. Here we report the solution structure of the isolated tetraloop receptor as solved by multidimensional, heteronuclear magnetic resonance spectroscopy. The internal loop of the tetraloop receptor has three adenosines stacked in a cross-strand or zipper-like fashion. This arrangement produces a high degree of base stacking within the asymmetric internal loop without extrahelical bases or kinking the helix. Additional interactions within the internal loop include a U. U mismatch pair and a G.U wobble pair. A comparison with the crystal structure of the receptor RNA bound to its tetraloop shows that a conformational change has to occur upon tetraloop binding, which is in good agreement with previous biochemical data. A model for an alternative binding site within the receptor is proposed based on the NMR structure, phylogenetic data and previous crystallographic structures of tetraloop interactions. PMID:9405377

[Volunteer satisfaction: Internal structure and relationship with permanence in organizations].

PubMed

Vecina Jiménez, M L; Chacón Fuertes, Fernando; Sueiro Abad, Manuel J

2009-02-01

Volunteer satisfaction: Internal structure and relationship with permanence in organizations. The concept of satisfaction is considered theoretically relevant in practically all the studies that have investigated the factors that influence the permanence of volunteer participation in organizations. However, the practical results are not conclusive, perhaps due to the wide range of ways in which the concept is understood and measured. The object of this study is: to analyse the internal structure of satisfaction and to verify its relationship with volunteer duration in organizations. The results of the factor analysis yield a three-factor structure: Satisfaction with the management of the organization, Satisfaction with the tasks, Satisfaction of motivations. The three factors allow us to differentiate between individuals who remain in the organization for a period of 12 consecutive months, and those who leave earlier. The results of structural equation model analysis show that the relationship between satisfaction and the length of time that volunteers stay with the organization is affected by the intention to remain.

Factor structure and internal reliability of an exercise health belief model scale in a Mexican population.

PubMed

Villar, Oscar Armando Esparza-Del; Montañez-Alvarado, Priscila; Gutiérrez-Vega, Marisela; Carrillo-Saucedo, Irene Concepción; Gurrola-Peña, Gloria Margarita; Ruvalcaba-Romero, Norma Alicia; García-Sánchez, María Dolores; Ochoa-Alcaraz, Sergio Gabriel

2017-03-01

Mexico is one of the countries with the highest rates of overweight and obesity around the world, with 68.8% of men and 73% of women reporting both. This is a public health problem since there are several health related consequences of not exercising, like having cardiovascular diseases or some types of cancers. All of these problems can be prevented by promoting exercise, so it is important to evaluate models of health behaviors to achieve this goal. Among several models the Health Belief Model is one of the most studied models to promote health related behaviors. This study validates the first exercise scale based on the Health Belief Model (HBM) in Mexicans with the objective of studying and analyzing this model in Mexico. Items for the scale called the Exercise Health Belief Model Scale (EHBMS) were developed by a health research team, then the items were applied to a sample of 746 participants, male and female, from five cities in Mexico. The factor structure of the items was analyzed with an exploratory factor analysis and the internal reliability with Cronbach's alpha. The exploratory factor analysis reported the expected factor structure based in the HBM. The KMO index (0.92) and the Barlett's sphericity test (p < 0.01) indicated an adequate and normally distributed sample. Items had adequate factor loadings, ranging from 0.31 to 0.92, and the internal consistencies of the factors were also acceptable, with alpha values ranging from 0.67 to 0.91. The EHBMS is a validated scale that can be used to measure exercise based on the HBM in Mexican populations.

In silico prediction of nematic transition temperature for liquid crystals using quantitative structure-property relationship approaches.

PubMed

Fatemi, Mohammad Hossein; Ghorbanzad'e, Mehdi

2009-11-01

Quantitative structure-property relationship models for the prediction of the nematic transition temperature (T (N)) were developed by using multilinear regression analysis and a feedforward artificial neural network (ANN). A collection of 42 thermotropic liquid crystals was chosen as the data set. The data set was divided into three sets: for training, and an internal and external test set. Training and internal test sets were used for ANN model development, and the external test set was used for evaluation of the predictive power of the model. In order to build the models, a set of six descriptors were selected by the best multilinear regression procedure of the CODESSA program. These descriptors were: atomic charge weighted partial negatively charged surface area, relative negative charged surface area, polarity parameter/square distance, minimum most negative atomic partial charge, molecular volume, and the A component of moment of inertia, which encode geometrical and electronic characteristics of molecules. These descriptors were used as inputs to ANN. The optimized ANN model had 6:6:1 topology. The standard errors in the calculation of T (N) for the training, internal, and external test sets using the ANN model were 1.012, 4.910, and 4.070, respectively. To further evaluate the ANN model, a crossvalidation test was performed, which produced the statistic Q (2) = 0.9796 and standard deviation of 2.67 based on predicted residual sum of square. Also, the diversity test was performed to ensure the model's stability and prove its predictive capability. The obtained results reveal the suitability of ANN for the prediction of T (N) for liquid crystals using molecular structural descriptors.

FAST Mast Structural Response to Axial Loading: Modeling and Verification

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Elliott, Kenny B.; Templeton, Justin D.; Song, Kyongchan; Rayburn, Jeffery T.

2012-01-01

The International Space Station s solar array wing mast shadowing problem is the focus of this paper. A building-block approach to modeling and analysis is pursued for the primary structural components of the solar array wing mast structure. Starting with an ANSYS (Registered Trademark) finite element model, a verified MSC.Nastran (Trademark) model is established for a single longeron. This finite element model translation requires the conversion of several modeling and analysis features for the two structural analysis tools to produce comparable results for the single-longeron configuration. The model is then reconciled using test data. The resulting MSC.Nastran (Trademark) model is then extended to a single-bay configuration and verified using single-bay test data. Conversion of the MSC. Nastran (Trademark) single-bay model to Abaqus (Trademark) is also performed to simulate the elastic-plastic longeron buckling response of the single bay prior to folding.

Internal friction in enzyme reactions.

PubMed

Rauscher, Anna; Derényi, Imre; Gráf, László; Málnási-Csizmadia, András

2013-01-01

The empirical concept of internal friction was introduced 20 years ago. This review summarizes the results of experimental and theoretical studies that help to uncover the nature of internal friction. After the history of the concept, we describe the experimental challenges in measuring and interpreting internal friction based on the viscosity dependence of enzyme reactions. We also present speculations about the structural background of this viscosity dependence. Finally, some models about the relationship between the energy landscape and internal friction are outlined. Alternative concepts regarding the viscosity dependence of enzyme reactions are also discussed. Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.

Internal protein motions in molecular-dynamics simulations of Bragg and diffuse X-ray scattering.

PubMed

Wall, Michael E

2018-03-01

Molecular-dynamics (MD) simulations of Bragg and diffuse X-ray scattering provide a means of obtaining experimentally validated models of protein conformational ensembles. This paper shows that compared with a single periodic unit-cell model, the accuracy of simulating diffuse scattering is increased when the crystal is modeled as a periodic supercell consisting of a 2 × 2 × 2 layout of eight unit cells. The MD simulations capture the general dependence of correlations on the separation of atoms. There is substantial agreement between the simulated Bragg reflections and the crystal structure; there are local deviations, however, indicating both the limitation of using a single structure to model disordered regions of the protein and local deviations of the average structure away from the crystal structure. Although it was anticipated that a simulation of longer duration might be required to achieve maximal agreement of the diffuse scattering calculation with the data using the supercell model, only a microsecond is required, the same as for the unit cell. Rigid protein motions only account for a minority fraction of the variation in atom positions from the simulation. The results indicate that protein crystal dynamics may be dominated by internal motions rather than packing interactions, and that MD simulations can be combined with Bragg and diffuse X-ray scattering to model the protein conformational ensemble.

Modeling functional neuroanatomy for an anatomy information system.

PubMed

Niggemann, Jörg M; Gebert, Andreas; Schulz, Stefan

2008-01-01

Existing neuroanatomical ontologies, databases and information systems, such as the Foundational Model of Anatomy (FMA), represent outgoing connections from brain structures, but cannot represent the "internal wiring" of structures and as such, cannot distinguish between different independent connections from the same structure. Thus, a fundamental aspect of Neuroanatomy, the functional pathways and functional systems of the brain such as the pupillary light reflex system, is not adequately represented. This article identifies underlying anatomical objects which are the source of independent connections (collections of neurons) and uses these as basic building blocks to construct a model of functional neuroanatomy and its functional pathways. The basic representational elements of the model are unnamed groups of neurons or groups of neuron segments. These groups, their relations to each other, and the relations to the objects of macroscopic anatomy are defined. The resulting model can be incorporated into the FMA. The capabilities of the presented model are compared to the FMA and the Brain Architecture Management System (BAMS). Internal wiring as well as functional pathways can correctly be represented and tracked. This model bridges the gap between representations of single neurons and their parts on the one hand and representations of spatial brain structures and areas on the other hand. It is capable of drawing correct inferences on pathways in a nervous system. The object and relation definitions are related to the Open Biomedical Ontology effort and its relation ontology, so that this model can be further developed into an ontology of neuronal functional systems.

Proposal of a socio-cognitive-behavioral structural equation model of internalized stigma in people with severe and persistent mental illness.

PubMed

Muñoz, Manuel; Sanz, María; Pérez-Santos, Eloísa; Quiroga, María de Los Ángeles

2011-04-30

The social stigma of mental illness has received much attention in recent years and its effects on diverse variables such as psychiatric symptoms, social functioning, self-esteem, self-efficacy, quality of life, and social integration are well established. However, internalized stigma in people with severe and persistent mental illness has not received the same attention. The aim of the present work was to study the relationships between the principal variables involved in the functioning of internalized stigma (sociodemographic and clinical variables, social stigma, psychosocial functioning, recovery expectations, empowerment, and discrimination experiences) in a sample of people with severe and persistent mental illness (N=108). The main characteristics of the sample and the differences between groups with high and low internalized stigma were analyzed, a correlation analysis of the variables was performed, and a structural equation model, integrating variables of social, cognitive, and behavioral content, was proposed and tested. The results indicate the relationships among social stigma, discrimination experiences, recovery expectation, and internalized stigma and their role in the psychosocial and behavioral outcomes in schizophrenia spectrum disorders. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Developmental effects of micronutrient supplementation and malaria in Zanzibari children

USDA-ARS?s Scientific Manuscript database

Background: Children’s development is affected by the interplay of internal and external factors and changes in one factor can precipitate changes in multiple developmental domains. Objective: To test a theoretical model of children’s development we used structural equation modeling to fit the model...

Correlations of External Landmarks With Internal Structures of the Temporal Bone.

PubMed

Piromchai, Patorn; Wijewickrema, Sudanthi; Smeds, Henrik; Kennedy, Gregor; O'Leary, Stephen

2015-09-01

The internal anatomy of a temporal bone could be inferred from external landmarks. Mastoid surgery is an important skill that ENT surgeons need to acquire. Surgeons commonly use CT scans as a guide to understanding anatomical variations before surgery. Conversely, in cases where CT scans are not available, or in the temporal bone laboratory where residents are usually not provided with CT scans, it would be beneficial if the internal anatomy of a temporal bone could be inferred from external landmarks. We explored correlations between internal anatomical variations and metrics established to quantify the position of external landmarks that are commonly exposed in the operating room, or the temporal bone laboratory, before commencement of drilling. Mathematical models were developed to predict internal anatomy based on external structures. From an operating room view, the distances between the following external landmarks were observed to have statistically significant correlations with the internal anatomy of a temporal bone: temporal line, external auditory canal, mastoid tip, occipitomastoid suture, and Henle's spine. These structures can be used to infer a low lying dura mater (p = 0.002), an anteriorly located sigmoid sinus (p = 0.006), and a more lateral course of the facial nerve (p < 0.001). In the temporal bone laboratory view, the mastoid tegmen and sigmoid sinus were also regarded as external landmarks. The distances between these two landmarks and the operating view external structures were able to further infer the laterality of the facial nerve (p < 0.001) and a sclerotic mastoid (p < 0.001). Two nonlinear models were developed that predicted the distances between the following internal structures with a high level of accuracy: the distance from the sigmoid sinus to the posterior external auditory canal (p < 0.001) and the diameter of the round window niche (p < 0.001). The prospect of encountering some of the more technically challenging anatomical variants encountered in temporal bone dissection can be inferred from the distance between external landmarks found on the temporal bone. These relationships could be used as a guideline to predict challenges during drilling and choosing appropriate temporal bones for dissection.

Radiosounding in the planned mission to Phobos

NASA Astrophysics Data System (ADS)

Zakharov, A. V.; Eismont, N. A.; Gotlib, V. M.; Smirnov, V. M.; Yushkova, O. V.; Marchuk, V. N.

2017-09-01

The opportunities to study Phobos' internal structure provided by radio methods are considered in this paper. The necessity of these studies is related to solution of the problem of the origin of the Martian moons. Radiosounding is one of the most efficient methods of analyzing the internal structure of small space objects and, in particular, that of Phobos. The new Boomerang project planned according to the Federal Space Program of Russia for 2016—2025 within the Expedition-M program aimed at the exploration of Phobos and delivery of soil samples from its surface to the Earth, as well as the specifics of a ballistic scenario of this expedition, provide a unique opportunity to carry out radioscopy of this space object to discover the internal structure Phobos and to solve the key problem of its origin. The model of Phobos' internal structure, radiosounding ballistic conditions, analysis of optimum frequency range of sounding, and key parameters of the device required for the experiment are considered in this paper. The significance of proposed studies and opportunities for their implementation are discussed.

The structure of internal stresses in the uncompacted ice cover

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sukhorukov, K.K.

1995-12-31

Interactions between engineering structures and sea ice cover are associated with an inhomogeneous space/time field of internal stresses. Field measurements (e.g., Coon, 1989; Tucker, 1992) have revealed considerable local stresses depending on the regional stress field and ice structure. These stresses appear in different time and space scales and depend on rheologic properties of the ice. To estimate properly the stressed state a knowledge of a connection between internal stress components in various regions of the ice cover is necessary. To develop reliable algorithms for estimates of ice action on engineering structures new experimental data are required to take intomore » account both microscale (comparable with local ice inhomogeneities) and small-scale (kilometers) inhomogeneities of the ice cover. Studies of compacted ice (concentration N is nearly 1) are mostly important. This paper deals with the small-scale spatial distribution of internal stresses in the interaction zone between the ice covers of various concentrations and icebergs. The experimental conditions model a situation of the interaction between a wide structure and the ice cover. Field data on a drifting ice were collected during the Russian-US experiment in Antarctica WEDDELL-I in 1992.« less

Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1×1 Nucleotide UU Internal Loop Conformations⊥

PubMed Central

Kumar, Amit; Park, HaJeung; Fang, Pengfei; Parkesh, Raman; Guo, Min; Nettles, Kendall W.; Disney, Matthew D.

2011-01-01

RNA internal loops often display a variety of conformations in solution. Herein, we visualize conformational heterogeneity in the context of the 5′CUG/3′GUC repeat motif present in the RNA that causes myotonic dystrophy type 1 (DM1). Specifically, two crystal structures are disclosed of a model DM1 triplet repeating construct, 5′r(UUGGGC(CUG)3GUCC)2, refined to 2.20 Å and 1.52 Å resolution. Here, differences in orientation of the 5′ dangling UU end between the two structures induce changes in the backbone groove width, which reveals that non-canonical 1×1 nucleotide UU internal loops can display an ensemble of pairing conformations. In the 2.20 Å structure, CUGa, the 5′UU forms one hydrogen-bonded pairs with a 5′UU of a neighboring helix in the unit cell to form a pseudo-infinite helix. The central 1×1 nucleotide UU internal loop has no hydrogen bonds, while the terminal 1×1 nucleotide UU internal loops each form a one hydrogen-bonded pair. In the 1.52 Å structure, CUGb, the 5′ UU dangling end is tucked into the major groove of the duplex. While the canonical paired bases show no change in base pairing, in CUGb the terminal 1×1 nucleotide UU internal loops form now two hydrogen-bonded pairs. Thus, the shift in major groove induced by the 5′UU dangling end alters non-canonical base patterns. Collectively, these structures indicate that 1×1 nucleotide UU internal loops in DM1 may sample multiple conformations in vivo. This observation has implications for the recognition of this RNA, and other repeating transcripts, by protein and small molecule ligands. PMID:21988728

Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations.

PubMed

Kumar, Amit; Park, HaJeung; Fang, Pengfei; Parkesh, Raman; Guo, Min; Nettles, Kendall W; Disney, Matthew D

2011-11-15

RNA internal loops often display a variety of conformations in solution. Herein, we visualize conformational heterogeneity in the context of the 5'CUG/3'GUC repeat motif present in the RNA that causes myotonic dystrophy type 1 (DM1). Specifically, two crystal structures of a model DM1 triplet repeating construct, 5'r[UUGGGC(CUG)(3)GUCC](2), refined to 2.20 and 1.52 Å resolution are disclosed. Here, differences in the orientation of the 5' dangling UU end between the two structures induce changes in the backbone groove width, which reveals that noncanonical 1 × 1 nucleotide UU internal loops can display an ensemble of pairing conformations. In the 2.20 Å structure, CUGa, the 5' UU forms a one hydrogen-bonded pair with a 5' UU of a neighboring helix in the unit cell to form a pseudoinfinite helix. The central 1 × 1 nucleotide UU internal loop has no hydrogen bonds, while the terminal 1 × 1 nucleotide UU internal loops each form a one-hydrogen bond pair. In the 1.52 Å structure, CUGb, the 5' UU dangling end is tucked into the major groove of the duplex. While the canonically paired bases show no change in base pairing, in CUGb the terminal 1 × 1 nucleotide UU internal loops now form two hydrogen-bonded pairs. Thus, the shift in the major groove induced by the 5' UU dangling end alters noncanonical base patterns. Collectively, these structures indicate that 1 × 1 nucleotide UU internal loops in DM1 may sample multiple conformations in vivo. This observation has implications for the recognition of this RNA, and other repeating transcripts, by protein and small molecule ligands.

Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Amit; Park, HaJeung; Fang, Pengfei

2012-03-27

RNA internal loops often display a variety of conformations in solution. Herein, we visualize conformational heterogeneity in the context of the 5'CUG/3'GUC repeat motif present in the RNA that causes myotonic dystrophy type 1 (DM1). Specifically, two crystal structures of a model DM1 triplet repeating construct, 5'r[{und UU}GGGC(C{und U}G){sub 3}GUCC]{sub 2}, refined to 2.20 and 1.52 {angstrom} resolution are disclosed. Here, differences in the orientation of the 5' dangling UU end between the two structures induce changes in the backbone groove width, which reveals that noncanonical 1 x 1 nucleotide UU internal loops can display an ensemble of pairing conformations.more » In the 2.20 {angstrom} structure, CUGa, the 5' UU forms a one hydrogen-bonded pair with a 5' UU of a neighboring helix in the unit cell to form a pseudoinfinite helix. The central 1 x 1 nucleotide UU internal loop has no hydrogen bonds, while the terminal 1 x 1 nucleotide UU internal loops each form a one-hydrogen bond pair. In the 1.52 {angstrom} structure, CUGb, the 5' UU dangling end is tucked into the major groove of the duplex. While the canonically paired bases show no change in base pairing, in CUGb the terminal 1 x 1 nucleotide UU internal loops now form two hydrogen-bonded pairs. Thus, the shift in the major groove induced by the 5' UU dangling end alters noncanonical base patterns. Collectively, these structures indicate that 1 x 1 nucleotide UU internal loops in DM1 may sample multiple conformations in vivo. This observation has implications for the recognition of this RNA, and other repeating transcripts, by protein and small molecule ligands.« less

Finite Element Simulation of Low Velocity Impact Damage on an Aeronautical Carbon Composite Structure

NASA Astrophysics Data System (ADS)

Lemanle Sanga, Roger Pierre; Garnier, Christian; Pantalé, Olivier

2016-12-01

Low velocity barely visible impact damage (BVID) in laminated carbon composite structures has a major importance for aeronautical industries. This contribution leads with the development of finite element models to simulate the initiation and the propagation of internal damage inside a carbon composite structure due by a low velocity impact. Composite plates made from liquid resin infusion process (LRI) have been subjected to low energy impacts (around 25 J) using a drop weight machine. In the experimental procedure, the internal damage is evaluated using an infrared thermographic camera while the indentation depth of the face is measured by optical measurement technique. In a first time we developed a robust model using homogenised shells based on degenerated tri-dimensional brick elements and in a second time we decided to modelize the whole stacking sequence of homogeneous layers and cohesive interlaminar interfaces in order to compare and validate the obtained results. Both layer and interface damage initiation and propagation models based on the Hashin and the Benzeggagh-Kenane criteria have been used for the numerical simulations. Comparison of numerical results and experiments has shown the accuracy of the proposed models.

Fear, Honor, Interest: An Analysis of Russia’s Operations in the Near Abroad (2007-2014)

DTIC Science & Technology

2015-05-21

model that reflects the internal structure of a decision-making system. This model delivers an approach of interrelated mechanisms based on history ...Cyber Warfare and the United States.” Denver Journal of International Law and Policy 40 (2012): 620-647 Laruelle, Marlene. “Negotiating History ...Russian minorities in former Soviet states. First, it describes the history of the collapse of the Soviet Union, the fate of the 25 million displaced

Nonlinear Analysis and Scaling Laws for Noncircular Composite Structures Subjected to Combined Loads

NASA Technical Reports Server (NTRS)

Hilburger, Mark W.; Rose, Cheryl A.; Starnes, James H., Jr.

2001-01-01

Results from an analytical study of the response of a built-up, multi-cell noncircular composite structure subjected to combined internal pressure and mechanical loads are presented. Nondimensional parameters and scaling laws based on a first-order shear-deformation plate theory are derived for this noncircular composite structure. The scaling laws are used to design sub-scale structural models for predicting the structural response of a full-scale structure representative of a portion of a blended-wing-body transport aircraft. Because of the complexity of the full-scale structure, some of the similitude conditions are relaxed for the sub-scale structural models. Results from a systematic parametric study are used to determine the effects of relaxing selected similitude conditions on the sensitivity of the effectiveness of using the sub-scale structural model response characteristics for predicting the full-scale structure response characteristics.

Tissue Expanders and Proton Beam Radiotherapy: What You Need to Know

PubMed Central

Howarth, Ashley L.; Niska, Joshua R.; Brooks, Kenneth; Anand, Aman; Bues, Martin; Vargas, Carlos E.

2017-01-01

Summary: Proton beam radiotherapy (PBR) has gained acceptance for the treatment of breast cancer because of unique beam characteristics that allow superior dose distributions with optimal dose to the target and limited collateral damage to adjacent normal tissue, especially to the heart and lungs. To determine the compatibility of breast tissue expanders (TEs) with PBR, we evaluated the structural and dosimetric properties of 2 ex vivo models: 1 model with internal struts and another model without an internal structure. Although the struts appeared to have minimal impact, we found that the metal TE port alters PBR dynamics, which may increase proton beam range uncertainty. Therefore, submuscular TE placement may be preferable to subcutaneous TE placement to reduce the interaction of the TE and proton beam. This will reduce range uncertainty and allow for more ideal radiation dose distribution. PMID:28740794

Internal state variable plasticity-damage modeling of AISI 4140 steel including microstructure-property relations: temperature and strain rate effects

NASA Astrophysics Data System (ADS)

Nacif el Alaoui, Reda

Mechanical structure-property relations have been quantified for AISI 4140 steel. under different strain rates and temperatures. The structure-property relations were used. to calibrate a microstructure-based internal state variable plasticity-damage model for. monotonic tension, compression and torsion plasticity, as well as damage evolution. Strong stress state and temperature dependences were observed for the AISI 4140 steel. Tension tests on three different notched Bridgman specimens were undertaken to study. the damage-triaxiality dependence for model validation purposes. Fracture surface. analysis was performed using Scanning Electron Microscopy (SEM) to quantify the void. nucleation and void sizes in the different specimens. The stress-strain behavior exhibited. a fairly large applied stress state (tension, compression dependence, and torsion), a. moderate temperature dependence, and a relatively small strain rate dependence.

Development and validation of a new population-based simulation model of osteoarthritis in New Zealand.

PubMed

Wilson, R; Abbott, J H

2018-04-01

To describe the construction and preliminary validation of a new population-based microsimulation model developed to analyse the health and economic burden and cost-effectiveness of treatments for knee osteoarthritis (OA) in New Zealand (NZ). We developed the New Zealand Management of Osteoarthritis (NZ-MOA) model, a discrete-time state-transition microsimulation model of the natural history of radiographic knee OA. In this article, we report on the model structure, derivation of input data, validation of baseline model parameters against external data sources, and validation of model outputs by comparison of the predicted population health loss with previous estimates. The NZ-MOA model simulates both the structural progression of radiographic knee OA and the stochastic development of multiple disease symptoms. Input parameters were sourced from NZ population-based data where possible, and from international sources where NZ-specific data were not available. The predicted distributions of structural OA severity and health utility detriments associated with OA were externally validated against other sources of evidence, and uncertainty resulting from key input parameters was quantified. The resulting lifetime and current population health-loss burden was consistent with estimates of previous studies. The new NZ-MOA model provides reliable estimates of the health loss associated with knee OA in the NZ population. The model structure is suitable for analysis of the effects of a range of potential treatments, and will be used in future work to evaluate the cost-effectiveness of recommended interventions within the NZ healthcare system. Copyright © 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Using Factor Mixture Models to Evaluate the Type A/B Classification of Alcohol Use Disorders in a Heterogeneous Treatment Sample

PubMed Central

Hildebrandt, Tom; Epstein, Elizabeth E.; Sysko, Robyn; Bux, Donald A.

2017-01-01

Background The type A/B classification model for alcohol use disorders (AUDs) has received considerable empirical support. However, few studies examine the underlying latent structure of this subtyping model, which has been challenged as a dichotomization of a single drinking severity dimension. Type B, relative to type A, alcoholics represent those with early age of onset, greater familial risk, and worse outcomes from alcohol use. Method We examined the latent structure of the type A/B model using categorical, dimensional, and factor mixture models in a mixed gender community treatment-seeking sample of adults with an AUD. Results Factor analytic models identified 2-factors (drinking severity/externalizing psychopathology and internalizing psychopathology) underlying the type A/B indicators. A factor mixture model with 2-dimensions and 3-classes emerged as the best overall fitting model. The classes reflected a type A class and two type B classes (B1 and B2) that differed on the respective level of drinking severity/externalizing pathology and internalizing pathology. Type B1 had a greater prevalence of women and more internalizing pathology and B2 had a greater prevalence of men and more drinking severity/externalizing pathology. The 2-factor, 3-class model also exhibited predictive validity by explaining significant variance in 12-month drinking and drug use outcomes. Conclusions The model identified in the current study may provide a basis for examining different sources of heterogeneity in the course and outcome of AUDs. PMID:28247423

Three Dimensional Characterization of Typical Urban and Desert Particles: Implications to Particle Optics

NASA Astrophysics Data System (ADS)

Goel, V.; Mishra, S.; Ahlawat, A. S.; Sharma, C.; Kotnala, R. K.

2017-12-01

Aerosol particles are generally considered as chemically homogeneous spheres in the retrieval techniques of ground and space borne observations which is not accurate approach and can lead to erroneous observations. For better simulation of optical and radiative properties of aerosols, a good knowledge of aerosol's morphology, chemical composition and internal structure is essential. Till date, many studies have reported the morphology and chemical composition of particles but very few of them provide internal structure and spatial distribution of different chemical species within the particle. The research on the effect of particle internal structure and its contribution to particle optics is extremely limited. In present work, we characterize the PM10 particles collected form typical arid (the Thar Desert, Rajasthan, India) and typical urban (New Delhi, India) environment using microscopic techniques. The particles were milled several times to investigate their internal structure. The EDS (Energy Dispersive X-ray Spectroscopy) spectra were recorded after each milling to check the variation in the chemical composition. In arid environment, Fe, Ca, C, Al, and Mg rich shell was observed over a Si rich particle whereas in urban environment, shell of Hg, Ag, C and N was observed over a Cu rich particle. Based on the observations, different model shapes [homogenous sphere and spheroid; heterogeneous sphere and spheroid; core shell] have been considered for assessing the associated uncertainties with the routine modeling of optical properties where volume equivalent homogeneous sphere approximation is considered. The details will be discussed during presentation.

Structural Model of the Effects of Poverty on Externalizing and Internalizing Behaviors of Four- to Five-Year-Old Children.

ERIC Educational Resources Information Center

Eamon, Mary Keegan

2000-01-01

Identifies the parenting practices that mediate relations between persistent, recent, and transitional poverty and the externalizing and internalizing behaviors of children four to five years old. Results reveal that lower-quality physical environment, maternal emotional unresponsiveness, and fewer stimulating experiences contribute significantly…

International Comparisons through Simultaneous and Conjunct Analysis: A Search for General Relationships across Countries.

ERIC Educational Resources Information Center

Lietz, Petra

1996-01-01

The six chapters of this theme issue explore data collected by the International Association for the Evaluation of Educational Achievement to investigate crucial issues in reading comprehension. Simultaneous analysis and conjunct analysis are used to examine models as structured combinations of factors in the search for relationships among…

Recovering bridge deflections from collocated acceleration and strain measurements

NASA Astrophysics Data System (ADS)

Bell, M.; Ma, T. W.; Xu, N. S.

2015-04-01

In this research, an internal model based method is proposed to estimate the displacement profile of a bridge subjected to a moving traffic load using a combination of acceleration and strain measurements. The structural response is assumed to be within the linear range. The deflection profile is assumed to be dominated by the fundamental mode of the bridge, therefore only requiring knowledge of the first mode. This still holds true under a multiple vehicle loading situation as the high mode shapes don't impact the over all response of the structure. Using the structural modal parameters and partial knowledge of the moving vehicle load, the internal models of the structure and the moving load can be respectively established, which can be used to form an autonomous state-space representation of the system. The structural displacements, velocities, and accelerations are the states of such a system, and it is fully observable when the measured output contains structural accelerations and strains. Reliable estimates of structural displacements are obtained using the standard Kalman filtering technique. The effectiveness and robustness of the proposed method has been demonstrated and evaluated via numerical simulation of a simply supported single span concrete bridge subjected to a moving traffic load.

Detection of bondline delaminations in multilayer structures with lossy components

NASA Technical Reports Server (NTRS)

Madaras, Eric I.; Winfree, William P.; Smith, B. T.; Heyman, Joseph H.

1988-01-01

The detection of bondline delaminations in multilayer structures using ultrasonic reflection techniques is a generic problem in adhesively bonded composite structures such as the Space Shuttles's Solid Rocket Motors (SRM). Standard pulse echo ultrasonic techniques do not perform well for a composite resonator composed of a resonant layer combined with attenuating layers. Excessive ringing in the resonant layer tends to mask internal echoes emanating from the attenuating layers. The SRM is made up of a resonant steel layer backed by layers of adhesive, rubber, liner and fuel, which are ultrasonically attenuating. The structure's response is modeled as a lossy ultrasonic transmission line. The model predicts that the acoustic response of the system is sensitive to delaminations at the interior bondlines in a few narrow frequency bands. These predictions are verified by measurements on a fabricated system. Successful imaging of internal delaminations is sensitive to proper selection of the interrogating frequency. Images of fabricated bondline delaminations are presented based on these studies.

A review and evaluation of the internal structure and consistency of the Approaches to Teaching Inventory

NASA Astrophysics Data System (ADS)

Harshman, Jordan; Stains, Marilyne

2017-05-01

This study presents a review from 39 studies that provide evidence for the structural validity and internal consistency of the Approaches to Teaching Inventory (ATI). In addition to this review, we evaluate many alternative factor structures on a sample of 267 first- and second-year chemistry faculty members participating in a professional development, a sample of instructors for which the ATI was originally designed. A total of 26 unique factor structures were evaluated. Through robust checking of assumptions, compilations of existing evidence, and new exploratory and confirmatory analyses, we found that there is greater evidence for the structural validity and internal consistency for the 22-item ATI than the 16-item ATI. Additionally, evidence supporting the original two-factor and four-factor structures proposed by the ATI authors (focusing on information transmission and conceptual change) were not reproducible and while alternative models were empirically viable, more theoretical justification is warranted. Recommendations for ATI use and general comments regarding best practices of reporting psychometrics in educational research contexts are discussed.

Measurement Invariance and the Five-Factor Model of Personality: Asian International and Euro American Cultural Groups.

PubMed

Rollock, David; Lui, P Priscilla

2016-10-01

This study examined measurement invariance of the NEO Five-Factor Inventory (NEO-FFI), assessing the five-factor model (FFM) of personality among Euro American (N = 290) and Asian international (N = 301) students (47.8% women, Mage = 19.69 years). The full 60-item NEO-FFI data fit the expected five-factor structure for both groups using exploratory structural equation modeling, and achieved configural invariance. Only 37 items significantly loaded onto the FFM-theorized factors for both groups and demonstrated metric invariance. Threshold invariance was not supported with this reduced item set. Groups differed the most in the item-factor relationships for Extraversion and Agreeableness, as well as in response styles. Asian internationals were more likely to use midpoint responses than Euro Americans. While the FFM can characterize broad nomothetic patterns of personality traits, metric invariance with only the subset of NEO-FFI items identified limits direct group comparisons of correlation coefficients among personality domains and with other constructs, and of mean differences on personality domains. © The Author(s) 2015.

Investigating the Latent Structure of the Teacher Efficacy Scale

ERIC Educational Resources Information Center

Wagler, Amy; Wagler, Ron

2013-01-01

This article reevaluates the latent structure of the Teacher Efficacy Scale using confirmatory factor analyses (CFAs) on a sample of preservice teachers from a public university in the U.S. Southwest. The fit of a proposed two-factor CFA model with an error correlation structure consistent with internal/ external locus of control is compared to…

The HTA Core Model®-10 Years of Developing an International Framework to Share Multidimensional Value Assessment.

PubMed

Kristensen, Finn Børlum; Lampe, Kristian; Wild, Claudia; Cerbo, Marina; Goettsch, Wim; Becla, Lidia

2017-02-01

The HTA Core Model ® as a science-based framework for assessing dimensions of value was developed as a part of the European network for Health Technology Assessment project in the period 2006 to 2008 to facilitate production and sharing of health technology assessment (HTA) information, such as evidence on efficacy and effectiveness and patient aspects, to inform decisions. It covers clinical value as well as organizational, economic, and patient aspects of technologies and has been field-tested in two consecutive joint actions in the period 2010 to 2016. A large number of HTA institutions were involved in the work. The model has undergone revisions and improvement after iterations of piloting and can be used in a local, national, or international context to produce structured HTA information that can be taken forward by users into their own frameworks to fit their specific needs when informing decisions on technology. The model has a broad scope and offers a common ground to various stakeholders through offering a standard structure and a transparent set of proposed HTA questions. It consists of three main components: 1) the HTA ontology, 2) methodological guidance, and 3) a common reporting structure. It covers domains such as effectiveness, safety, and economics, and also includes domains covering organizational, patient, social, and legal aspects. There is a full model and a focused rapid relative effectiveness assessment model, and a third joint action is to continue till 2020. The HTA Core Model is now available for everyone around the world as a framework for assessing value. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Micro-scale investigation on the quasi-static behavior of granular material

NASA Astrophysics Data System (ADS)

Li, Xia

Granular material exhibits complex responses when subjected to various external loading. Fundamental mechanisms have not been well established so far, including that about the critical state, one of the most important concepts in the modern soil mechanics. With the recognition that granular material is discrete in nature, the basic understanding can only be obtained from the particle scale. The complexity in granular material behavior lies in the fact that the macroscopic behavior of granular material is determined by not only the interactions operating at contacts, but also how the particles become arranged in space to form an internal structure. This research is aimed to microscopically investigate the influence of the internal structure and the fundamental mechanism about the critical state. In view of the extensive laboratory test data already available in the literature, a numerical simulation method, DEM, is employed as the tool to conduct particle-scale investigations. The contact model for two in-contact circular disks is derived theoretically from the elasticity theory, and the result is a linear contact model with constant stiffness and lateral sliding. Based on the contact model, a systematic series of numerical tests has been implemented, and the results can successfully reproduce the main characteristics in the behavior of natural granular material, under various loading conditions. The macro-micro relationship is the link between the investigations at the two worlds. The key point is to describe the internal structure with the two dual cell systems, a particle cell system and a void cell system. Based on these two systems, the stress and strain in a uniform field are equivalently expressed in terms of the contact forces/relative displacements, and the micro-geometrical variables. With the microstructural definition of the stress tensor, the stress state of granular material is studied microscopically. The stress-fabric-force relation is derived, based on the variables describing the statistics of the contact forces and the contact vectors. By studying the evolution of the micro-quantities during shearing, how the internal structure affects the macro stress state under different loading condition is revealed. With the assumption that the influence of the local variance in stress is ignorable, the response of granular material can be investigated based on the void cell system. Starting from the behavior of a single void cell, the evolutions of the internal structure and its influence on the response of granular material are explained. The stress ratio and the dilatancy behavior of granular material are investigated. The influences of the void ratio, the mean normal stress and the drainage condition are discussed. The fundamental mechanism of the critical state is studied in the framework of thermodynamics with properly considering the influence of the internal structure. The normalized stress ratio tensor at critical state is associated with the critical void cell anisotropy, corresponding to the maximal energy dissipation. The (e, p) relationship at critical state is associated with the critical combination of the void cell size and the contact interactions, corresponding to the minimal free energy. The investigation on the influence of the internal structure anisotropy on the granular material behavior and the critical state is carried out. The results show that at small strain levels, the behavior of granular material is mainly affected by the initial fabric. As shearing continuous, the internal structure of granular material is gradually changed. The granular material approaches the critical state, which is irrespective with the initial internal structure. The critical state of granular material is not unique. With different loading modes, the critical state of granular material, including both the critical stress ratio and the critical (e, p) relations, are found to be different. A fabric tensor is defined based on the characteristics of the void cells. The laboratory method to quantify the fabric anisotropy is proposed by deviatoric shearing. 3D numerical simulations have been carried out to investigate the influence of the loading mode, which is found to be an important factor in the large strain behavior of granular material. With the obtained microscopic understanding, the influence of contact model on granular material behavior is investigated. A method to quantify the fabric anisotropy is proposed. And a simple discussion on the state variable used in the elasto-plastic constitutive model is given.

Central Appalachia in advanced capitalism: its coal industry structure and coal operator associations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walls, D.S.

1978-01-01

This study traces the origins of the notion that Appalachia constitutes a unique social-problem region, examines the models of Appalachian problems popularized during the 1960s, proposes an alternative framework for situating the Central Appalachian coalfields, and examines aspects of the coal industry's structure in the Central Appalachian region. The idea of Appalachia as a distinctive social problem region was created between 1890 and 1930 by a social movement affiliated with various Protestant church home mission boards and organizationally focused in the Conference of Southern Mountain Workers and Berea College. The movement stressed an environmental explanation of regional problems. During themore » 1960s, three explanatory models of Appalachian poverty and underdevelopment achieved prominence: the subculture of poverty model, the regional development model, and the internal colonialism model. Each contributed to a regionalized conception of Appalachian problems. Empirical studies show the subculture of poverty model to fail as an explanation of regional underdevelopment. In the absence of a critique of domination and a redistribution of power and wealth, the regional development model serves as a rationalization of existing structures of privilege. The internal colonialism model provides a critique of domination, but not the most appropriate one. This study argues that the above models should not be viewed as mutually exclusive formulations, and that they may be reconstructed to represent different dimensions of social existence.« less

Internalized stigma and quality of life domains among people with mental illness: the mediating role of self-esteem.

PubMed

Oliveira, Sandra E H; Carvalho, Helena; Esteves, Francisco

2016-01-01

People with mental illness who internalize stigma often experience reduced self-esteem and impaired quality of life (QOL). To propose a theoretical model in which self-esteem mediates the effects of internalized stigma on the multidimensional domains comprising QOL. In 403 inpatients and outpatients (DSM-IV, American Psychiatric Association, 1994), from hospital-based and community mental health facilities, self-report measures of internalized stigma (ISMI), self-esteem (RSES) and QOL (WHOQOL-Bref) were administrated. Structural equation modeling results supported the proposed model. Self-esteem fully mediated the relation between internalized stigma and the physical and the social relationships domains, and partially mediated the relationship between internalized stigma and psychological, environment and level of independence QOL domains. Such results provided empirical support and shed light upon previous research. Specifically the results emphasize the mediating role that self-esteem plays in the degree to which internalized stigma exerts a negative effect on specific QOL domains. Self-esteem appears to be a core element in reducing the negative effects of internalized stigma on aspects of QOL among people with mental illness. These findings suggest there is a crucial impact regarding clinical mental health interventions along with important theoretical implications.

FAA/NASA International Symposium on Advanced Structural Integrity Methods for Airframe Durability and Damage Tolerance

NASA Technical Reports Server (NTRS)

Harris, Charles E. (Editor)

1994-01-01

International technical experts in durability and damage tolerance of metallic airframe structures were assembled to present and discuss recent research findings and the development of advanced design and analysis methods, structural concepts, and advanced materials. The symposium focused on the dissemination of new knowledge and the peer-review of progress on the development of advanced methodologies. Papers were presented on: structural concepts for enhanced durability, damage tolerance, and maintainability; new metallic alloys and processing technology; fatigue crack initiation and small crack effects; fatigue crack growth models; fracture mechanics failure, criteria for ductile materials; structural mechanics methodology for residual strength and life prediction; development of flight load spectra for design and testing; and advanced approaches to resist corrosion and environmentally assisted fatigue.

FAA/NASA International Symposium on Advanced Structural Integrity Methods for Airframe Durability and Damage Tolerance, part 2

NASA Technical Reports Server (NTRS)

Harris, Charles E. (Editor)

1994-01-01

The international technical experts in the areas of durability and damage tolerance of metallic airframe structures were assembled to present and discuss recent research findings and the development of advanced design and analysis methods, structural concepts, and advanced materials. The principal focus of the symposium was on the dissemination of new knowledge and the peer-review of progress on the development of advanced methodologies. Papers were presented on the following topics: structural concepts for enhanced durability, damage tolerance, and maintainability; new metallic alloys and processing technology; fatigue crack initiation and small crack effects; fatigue crack growth models; fracture mechanics failure criteria for ductile materials; structural mechanics methodology for residual strength and life prediction; development of flight load spectra for design and testing; and corrosion resistance.

The role of internal duplication in the evolution of multi-domain proteins.

PubMed

Nacher, J C; Hayashida, M; Akutsu, T

2010-08-01

Many proteins consist of several structural domains. These multi-domain proteins have likely been generated by selective genome growth dynamics during evolution to perform new functions as well as to create structures that fold on a biologically feasible time scale. Domain units frequently evolved through a variety of genetic shuffling mechanisms. Here we examine the protein domain statistics of more than 1000 organisms including eukaryotic, archaeal and bacterial species. The analysis extends earlier findings on asymmetric statistical laws for proteome to a wider variety of species. While proteins are composed of a wide range of domains, displaying a power-law decay, the computation of domain families for each protein reveals an exponential distribution, characterizing a protein universe composed of a thin number of unique families. Structural studies in proteomics have shown that domain repeats, or internal duplicated domains, represent a small but significant fraction of genome. In spite of its importance, this observation has been largely overlooked until recently. We model the evolutionary dynamics of proteome and demonstrate that these distinct distributions are in fact rooted in an internal duplication mechanism. This process generates the contemporary protein structural domain universe, determines its reduced thickness, and tames its growth. These findings have important implications, ranging from protein interaction network modeling to evolutionary studies based on fundamental mechanisms governing genome expansion.

The 3D geological model of the 1963 Vajont rockslide, reconstructed with implicit surface methods

NASA Astrophysics Data System (ADS)

Bistacchi, Andrea; Massironi, Matteo; Francese, Roberto; Giorgi, Massimo; Taller, Claudio

2015-04-01

The Vajont rockslide has been the object of several studies because of its catastrophic consequences and of its particular evolution. Several qualitative or quantitative models have been presented in the last 50 years, but a complete explanation of all the relevant geological and mechanical processes remains elusive. In order to better understand the mechanics and dynamics of the 1963 event, we have reconstructed the first 3D geological model of the rockslide, which allowed us to accurately investigate the rockslide structure and kinematics. The input data for the model consisted in: pre- and post-rockslide geological maps, pre- and post-rockslide orthophotos, pre- and post-rockslide digital elevation models, structural data, boreholes, and geophysical data (2D and 3D seismics and resistivity). All these data have been integrated in a 3D geological model implemented in Gocad®, using the implicit surface modelling method. Results of the 3D geological model include the depth and geometry of the sliding surface, the volume of the two lobes of the rockslide accumulation, kinematics of the rockslide in terms of the vector field of finite displacement, and high quality meshes useful for mechanical and hydrogeological simulations. The latter can include information about the stratigraphy and internal structure of the rock masses and allow tracing the displacement of different material points in the rockslide from the pre-1963-failure to the post-rockslide state. As a general geological conclusion, we may say that the 3D model allowed us to recognize very effectively a sliding surface, whose non-planar geometry is affected by the interference pattern of two regional-scale fold systems. The rockslide is partitioned into two distinct and internally continuous rock masses with a distinct kinematics, which were characterised by a very limited internal deformation during the slide. The continuity of these two large blocks points to a very localized deformation, occurring along a thin, continuous and weak cataclastic horizon. Finally, the chosen modelling strategy, based on both traditional "explicit" and implicit techniques, was found to be very effective for reconstructing complex folded and faulted geological structures, and could be applied also to other geological environments.

The anatomy of the thrips Heliothrips haemorrhoidalis (Thysanoptera, Thripidae) and its specific features caused by miniaturization.

PubMed

Polilov, Alexey A; Shmakov, Alexey S

2016-09-01

A new set of data on the internal and external structure of the adult and larva of the thrips Heliothrips haemorrhoidalis (Bouché, 1833) is presented. The structure of the internal systems of this thrips was revealed using modern methods of 3D computer modelling. The changes in shape and relative size are discussed as an outcome of miniaturization in comparison to the supposed ancestor of this species. The layout of the internal systems of thrips is compared to those of other insects similar in size: beetles of the families Ptiliidae and Corylophidae and wasps of the families Mymaridae and Trichogrammatidae. Copyright © 2016 Elsevier Ltd. All rights reserved.

[Design of Complex Cavity Structure in Air Route System of Automated Peritoneal Dialysis Machine].

PubMed

Quan, Xiaoliang

2017-07-30

This paper introduced problems about Automated Peritoneal Dialysis machine(APD) that the lack of technical issues such as the structural design of the complex cavities. To study the flow characteristics of this special structure, the application of ANSYS CFX software is used with k-ε turbulence model as the theoretical basis of fluid mechanics. The numerical simulation of flow field simulation result in the internal model can be gotten after the complex structure model is imported into ANSYS CFX module. Then, it will present the distribution of complex cavities inside the flow field and the flow characteristics parameter, which will provide an important reference design for APD design.

Constraining the volatile fraction of planets from transit observations

NASA Astrophysics Data System (ADS)

Alibert, Y.

2016-06-01

Context. The determination of the abundance of volatiles in extrasolar planets is very important as it can provide constraints on transport in protoplanetary disks and on the formation location of planets. However, constraining the internal structure of low-mass planets from transit measurements is known to be a degenerate problem. Aims: Using planetary structure and evolution models, we show how observations of transiting planets can be used to constrain their internal composition, in particular the amount of volatiles in the planetary interior, and consequently the amount of gas (defined in this paper to be only H and He) that the planet harbors. We first explore planets that are located close enough to their star to have lost their gas envelope. We then concentrate on planets at larger distances and show that the observation of transiting planets at different evolutionary ages can provide statistical information on their internal composition, in particular on their volatile fraction. Methods: We computed the evolution of low-mass planets (super-Earths to Neptune-like) for different fractions of volatiles and gas. We used a four-layer model (core, silicate mantle, icy mantle, and gas envelope) and computed the internal structure of planets for different luminosities. With this internal structure model, we computed the internal and gravitational energy of planets, which was then used to derive the time evolution of the planet. Since the total energy of a planet depends on its heat capacity and density distribution and therefore on its composition, planets with different ice fractions have different evolution tracks. Results: We show for low-mass gas-poor planets that are located close to their central star that assuming evaporation has efficiently removed the entire gas envelope, it is possible to constrain the volatile fraction of close-in transiting planets. We illustrate this method on the example of 55 Cnc e and show that under the assumption of the absence of gas, the measured mass and radius imply at least 20% of volatiles in the interior. For planets at larger distances, we show that the observation of transiting planets at different evolutionary ages can be used to set statistical constraints on the volatile content of planets. Conclusions: These results can be used in the context of future missions like PLATO to better understand the internal composition of planets, and based on this, their formation process and potential habitability.

Prediction of biodegradability from chemical structure: Modeling or ready biodegradation test data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loonen, H.; Lindgren, F.; Hansen, B.

1999-08-01

Biodegradation data were collected and evaluated for 894 substances with widely varying chemical structures. All data were determined according to the Japanese Ministry of International Trade and Industry (MITI) I test protocol. The MITI I test is a screening test for ready biodegradability and has been described by Organization for Economic Cooperation and Development (OECD) test guideline 301 C and European Union (EU) test guideline C4F. The chemicals were characterized by a set of 127 predefined structural fragments. This data set was used to develop a model for the prediction of the biodegradability of chemicals under standardized OECD and EUmore » ready biodegradation test conditions. Partial least squares (PLS) discriminant analysis was used for the model development. The model was evaluated by means of internal cross-validation and repeated external validation. The importance of various structural fragments and fragment interactions was investigated. The most important fragments include the presence of a long alkyl chain; hydroxy, ester, and acid groups (enhancing biodegradation); and the presence of one or more aromatic rings and halogen substituents (regarding biodegradation). More than 85% of the model predictions were correct for using the complete data set. The not readily biodegradable predictions were slightly better than the readily biodegradable predictions (86 vs 84%). The average percentage of correct predictions from four external validation studies was 83%. Model optimization by including fragment interactions improve the model predicting capabilities to 89%. It can be concluded that the PLS model provides predictions of high reliability for a diverse range of chemical structures. The predictions conform to the concept of readily biodegradable (or not readily biodegradable) as defined by OECD and EU test guidelines.« less

Photogrammetric Modeling and Image-Based Rendering for Rapid Virtual Environment Creation

DTIC Science & Technology

2004-12-01

area and different methods have been proposed. Pertinent methods include: Camera Calibration , Structure from Motion, Stereo Correspondence, and Image...Based Rendering 1.1.1 Camera Calibration Determining the 3D structure of a model from multiple views becomes simpler if the intrinsic (or internal...can introduce significant nonlinearities into the image. We have found that camera calibration is a straightforward process which can simplify the

Automated Generation of Finite-Element Meshes for Aircraft Conceptual Design

NASA Technical Reports Server (NTRS)

Li, Wu; Robinson, Jay

2016-01-01

This paper presents a novel approach for automated generation of fully connected finite-element meshes for all internal structural components and skins of a given wing-body geometry model, controlled by a few conceptual-level structural layout parameters. Internal structural components include spars, ribs, frames, and bulkheads. Structural layout parameters include spar/rib locations in wing chordwise/spanwise direction and frame/bulkhead locations in longitudinal direction. A simple shell thickness optimization problem with two load conditions is used to verify versatility and robustness of the automated meshing process. The automation process is implemented in ModelCenter starting from an OpenVSP geometry and ending with a NASTRAN 200 solution. One subsonic configuration and one supersonic configuration are used for numerical verification. Two different structural layouts are constructed for each configuration and five finite-element meshes of different sizes are generated for each layout. The paper includes various comparisons of solutions of 20 thickness optimization problems, as well as discussions on how the optimal solutions are affected by the stress constraint bound and the initial guess of design variables.

Modelling large deformation and soil—water—structure interaction with material point method: Briefing on MPM2017 conference

NASA Astrophysics Data System (ADS)

Rohe, Alexander; Liang, Dongfang

2017-06-01

The 1st International Conference on the Material Point Method for "Modelling Large Deformation and Soil-Water-Structure Interaction" (MPM2017) was held in Delft, The Netherlands on 10-13 January 2017. This is the first conference organised by the Anura3D MPM Research Community, following a series of international workshops and symposia previously held in The Netherlands, UK, Spain and Italy, as part of the European Commission FP7 Marie-Curie project MPM-DREDGE. We are delighted to present seven contributions in this Special Column of the Journal of Hydrodynamics, and take this opportunity to announce that the 2nd conference, MPM2019, will be held in Cambridge, UK in January 2019.

Adding thin-ideal internalization and impulsiveness to the cognitive-behavioral model of bulimic symptoms.

PubMed

Schnitzler, Caroline E; von Ranson, Kristin M; Wallace, Laurel M

2012-08-01

This study evaluated the cognitive-behavioral (CB) model of bulimia nervosa and an extension that included two additional maintaining factors - thin-ideal internalization and impulsiveness - in 327 undergraduate women. Participants completed measures of demographics, self-esteem, concern about shape and weight, dieting, bulimic symptoms, thin-ideal internalization, and impulsiveness. Both the original CB model and the extended model provided good fits to the data. Although structural equation modeling analyses suggested that the original CB model was most parsimonious, hierarchical regression analyses indicated that the additional variables accounted for significantly more variance. Additional analyses showed that the model fit could be improved by adding a path from concern about shape and weight, and deleting the path from dieting, to bulimic symptoms. Expanding upon the factors considered in the model may better capture the scope of variables maintaining bulimic symptoms in young women with a range of severity of bulimic symptoms. Copyright © 2012 Elsevier Ltd. All rights reserved.

How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model

PubMed Central

Hameed, Imran; Riaz, Zahid; Arain, Ghulam A.; Farooq, Omer

2016-01-01

The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail. PMID:27303345

How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model.

PubMed

Hameed, Imran; Riaz, Zahid; Arain, Ghulam A; Farooq, Omer

2016-01-01

The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail.

Entropy model of dissipative structure on corporate social responsibility

NASA Astrophysics Data System (ADS)

Li, Zuozhi; Jiang, Jie

2017-06-01

Enterprise is prompted to fulfill the social responsibility requirement by the internal and external environment. In this complex system, some studies suggest that firms have an orderly or chaotic entropy exchange behavior. Based on the theory of dissipative structure, this paper constructs the entropy index system of corporate social responsibility(CSR) and explores the dissipative structure of CSR through Brusselator model criterion. Picking up listed companies of the equipment manufacturing, the research shows that CSR has positive incentive to negative entropy and promotes the stability of dissipative structure. In short, the dissipative structure of CSR has a positive impact on the interests of stakeholders and corporate social images.

Psychometric Properties and Factor Structure of the German Version of the Clinician-Administered PTSD Scale for DSM-5.

PubMed

Müller-Engelmann, Meike; Schnyder, Ulrich; Dittmann, Clara; Priebe, Kathlen; Bohus, Martin; Thome, Janine; Fydrich, Thomas; Pfaltz, Monique C; Steil, Regina

2018-05-01

The Clinician-Administered PTSD Scale (CAPS) is a widely used diagnostic interview for posttraumatic stress disorder (PTSD). Following fundamental modifications in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ( DSM-5), the CAPS had to be revised. This study examined the psychometric properties (internal consistency, interrater reliability, convergent and discriminant validity, and structural validity) of the German version of the CAPS-5 in a trauma-exposed sample ( n = 223 with PTSD; n =51 without PTSD). The results demonstrated high internal consistency (αs = .65-.93) and high interrater reliability (ICCs = .81-.89). With regard to convergent and discriminant validity, we found high correlations between the CAPS severity score and both the Posttraumatic Diagnostic Scale sum score ( r = .87) and the Beck Depression Inventory total score ( r = .72). Regarding the underlying factor structure, the hybrid model demonstrated the best fit, followed by the anhedonia model. However, we encountered some nonpositive estimates for the correlations of the latent variables (factors) for both models. The model with the best fit without methodological problems was the externalizing behaviors model, but the results also supported the DSM-5 model. Overall, the results demonstrate that the German version of the CAPS-5 is a psychometrically sound measure.

On the generation of climate model ensembles

NASA Astrophysics Data System (ADS)

Haughton, Ned; Abramowitz, Gab; Pitman, Andy; Phipps, Steven J.

2014-10-01

Climate model ensembles are used to estimate uncertainty in future projections, typically by interpreting the ensemble distribution for a particular variable probabilistically. There are, however, different ways to produce climate model ensembles that yield different results, and therefore different probabilities for a future change in a variable. Perhaps equally importantly, there are different approaches to interpreting the ensemble distribution that lead to different conclusions. Here we use a reduced-resolution climate system model to compare three common ways to generate ensembles: initial conditions perturbation, physical parameter perturbation, and structural changes. Despite these three approaches conceptually representing very different categories of uncertainty within a modelling system, when comparing simulations to observations of surface air temperature they can be very difficult to separate. Using the twentieth century CMIP5 ensemble for comparison, we show that initial conditions ensembles, in theory representing internal variability, significantly underestimate observed variance. Structural ensembles, perhaps less surprisingly, exhibit over-dispersion in simulated variance. We argue that future climate model ensembles may need to include parameter or structural perturbation members in addition to perturbed initial conditions members to ensure that they sample uncertainty due to internal variability more completely. We note that where ensembles are over- or under-dispersive, such as for the CMIP5 ensemble, estimates of uncertainty need to be treated with care.

Linear decentralized systems with special structure. [for twin lift helicopters

NASA Technical Reports Server (NTRS)

Martin, C. F.

1982-01-01

Certain fundamental structures associated with linear systems having internal symmetries are outlined. It is shown that the theory of finite-dimensional algebras and their representations are closely related to such systems. It is also demonstrated that certain problems in the decentralized control of symmetric systems are equivalent to long-standing problems of linear systems theory. Even though the structure imposed arose in considering the problems of twin-lift helicopters, any large system composed of several identical intercoupled control systems can be modeled by a linear system that satisfies the constraints imposed. Internal symmetry can be exploited to yield new system-theoretic invariants and a better understanding of the way in which the underlying structure affects overall system performance.

Conceptualizing a model: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force--2.

PubMed

Roberts, Mark; Russell, Louise B; Paltiel, A David; Chambers, Michael; McEwan, Phil; Krahn, Murray

2012-01-01

The appropriate development of a model begins with understanding the problem that is being represented. The aim of this article was to provide a series of consensus-based best practices regarding the process of model conceptualization. For the purpose of this series of articles, we consider the development of models whose purpose is to inform medical decisions and health-related resource allocation questions. We specifically divide the conceptualization process into two distinct components: the conceptualization of the problem, which converts knowledge of the health care process or decision into a representation of the problem, followed by the conceptualization of the model itself, which matches the attributes and characteristics of a particular modeling type with the needs of the problem being represented. Recommendations are made regarding the structure of the modeling team, agreement on the statement of the problem, the structure, perspective, and target population of the model, and the interventions and outcomes represented. Best practices relating to the specific characteristics of model structure and which characteristics of the problem might be most easily represented in a specific modeling method are presented. Each section contains a number of recommendations that were iterated among the authors, as well as among the wider modeling taskforce, jointly set up by the International Society for Pharmacoeconomics and Outcomes Research and the Society for Medical Decision Making. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

A systematic multiscale modeling and experimental approach to protect grain boundaries in magnesium alloys from corrosion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horstemeyer, Mark R.; Chaudhuri, Santanu

2015-09-30

A multiscale modeling Internal State Variable (ISV) constitutive model was developed that captures the fundamental structure-property relationships. The macroscale ISV model used lower length scale simulations (Butler-Volmer and Electronics Structures results) in order to inform the ISVs at the macroscale. The chemomechanical ISV model was calibrated and validated from experiments with magnesium (Mg) alloys that were investigated under corrosive environments coupled with experimental electrochemical studies. Because the ISV chemomechanical model is physically based, it can be used for other material systems to predict corrosion behavior. As such, others can use the chemomechanical model for analyzing corrosion effects on their designs.

Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling.

PubMed

Jo, Sunhwan; Lee, Hui Sun; Skolnick, Jeffrey; Im, Wonpil

2013-01-01

Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions. Given the difficulties in obtaining the glycan's crystal structure in glycoconjugates due to its flexibility and heterogeneity, computational modeling could play an important role in providing glycosylated protein structure models. To address if glycan structures available in the PDB can be used as templates or fragments for glycan modeling, we present a survey of the N-glycan structures of 35 different sequences in the PDB. Our statistical analysis shows that the N-glycan structures found on homologous glycoproteins are significantly conserved compared to the random background, suggesting that N-glycan chains can be confidently modeled with template glycan structures whose parent glycoproteins share sequence similarity. On the other hand, N-glycan structures found on non-homologous glycoproteins do not show significant global structural similarity. Nonetheless, the internal substructures of these N-glycans, particularly, the substructures that are closer to the protein, show significantly similar structures, suggesting that such substructures can be used as fragments in glycan modeling. Increased interactions with protein might be responsible for the restricted conformational space of N-glycan chains. Our results suggest that structure prediction/modeling of N-glycans of glycoconjugates using structure database could be effective and different modeling approaches would be needed depending on the availability of template structures.

Restricted N-glycan Conformational Space in the PDB and Its Implication in Glycan Structure Modeling

PubMed Central

Jo, Sunhwan; Lee, Hui Sun; Skolnick, Jeffrey; Im, Wonpil

2013-01-01

Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions. Given the difficulties in obtaining the glycan's crystal structure in glycoconjugates due to its flexibility and heterogeneity, computational modeling could play an important role in providing glycosylated protein structure models. To address if glycan structures available in the PDB can be used as templates or fragments for glycan modeling, we present a survey of the N-glycan structures of 35 different sequences in the PDB. Our statistical analysis shows that the N-glycan structures found on homologous glycoproteins are significantly conserved compared to the random background, suggesting that N-glycan chains can be confidently modeled with template glycan structures whose parent glycoproteins share sequence similarity. On the other hand, N-glycan structures found on non-homologous glycoproteins do not show significant global structural similarity. Nonetheless, the internal substructures of these N-glycans, particularly, the substructures that are closer to the protein, show significantly similar structures, suggesting that such substructures can be used as fragments in glycan modeling. Increased interactions with protein might be responsible for the restricted conformational space of N-glycan chains. Our results suggest that structure prediction/modeling of N-glycans of glycoconjugates using structure database could be effective and different modeling approaches would be needed depending on the availability of template structures. PMID:23516343

New insights on the voltage dependence of the KCa3.1 channel block by internal TBA.

PubMed

Banderali, Umberto; Klein, Hélène; Garneau, Line; Simoes, Manuel; Parent, Lucie; Sauvé, Rémy

2004-10-01

We present in this work a structural model of the open IKCa (KCa3.1) channel derived by homology modeling from the MthK channel structure, and used this model to compute the transmembrane potential profile along the channel pore. This analysis showed that the selectivity filter and the region extending from the channel inner cavity to the internal medium should respectively account for 81% and 16% of the transmembrane potential difference. We found however that the voltage dependence of the IKCa block by the quaternary ammonium ion TBA applied internally is compatible with an apparent electrical distance delta of 0.49 +/- 0.02 (n = 6) for negative potentials. To reconcile this observation with the electrostatic potential profile predicted for the channel pore, we modeled the IKCa block by TBA assuming that the voltage dependence of the block is governed by both the difference in potential between the channel cavity and the internal medium, and the potential profile along the selectivity filter region through an effect on the filter ion occupancy states. The resulting model predicts that delta should be voltage dependent, being larger at negative than positive potentials. The model also indicates that raising the internal K+ concentration should decrease the value of delta measured at negative potentials independently of the external K+ concentration, whereas raising the external K+ concentration should minimally affect delta for concentrations >50 mM. All these predictions are born out by our current experimental results. Finally, we found that the substitutions V275C and V275A increased the voltage sensitivity of the TBA block, suggesting that TBA could move further into the pore, thus leading to stronger interactions between TBA and the ions in the selectivity filter. Globally, these results support a model whereby the voltage dependence of the TBA block in IKCa is mainly governed by the voltage dependence of the ion occupancy states of the selectivity filter.

A conflict model for the international hazardous waste disposal dispute.

PubMed

Hu, Kaixian; Hipel, Keith W; Fang, Liping

2009-12-15

A multi-stage conflict model is developed to analyze international hazardous waste disposal disputes. More specifically, the ongoing toxic waste conflicts are divided into two stages consisting of the dumping prevention and dispute resolution stages. The modeling and analyses, based on the methodology of graph model for conflict resolution (GMCR), are used in both stages in order to grasp the structure and implications of a given conflict from a strategic viewpoint. Furthermore, a specific case study is investigated for the Ivory Coast hazardous waste conflict. In addition to the stability analysis, sensitivity and attitude analyses are conducted to capture various strategic features of this type of complicated dispute.

Modelling explicit tides in the Indonesian seas: An important process for surface sea water properties.

PubMed

Nugroho, Dwiyoga; Koch-Larrouy, Ariane; Gaspar, Philippe; Lyard, Florent; Reffray, Guillaume; Tranchant, Benoit

2018-06-01

Very intense internal tides take place in Indonesian seas. They dissipate and affect the vertical distribution of temperature and currents, which in turn influence the survival rates and transports of most planktonic organisms at the base of the whole marine ecosystem. This study uses the INDESO physical model to characterize the internal tides spatio-temporal patterns in the Indonesian Seas. The model reproduced internal tide dissipation in agreement with previous fine structure and microstructure observed in-situ in the sites of generation. The model also produced similar water mass transformation as the previous parameterization of Koch-Larrouy et al. (2007), and show good agreement with observations. The resulting cooling at the surface is 0.3°C, with maxima of 0.8°C at the location of internal tides energy, with stronger cooling in austral winter. The cycle of spring tides and neap tides modulates this impact by 0.1°C to 0.3°C. These results suggest that mixing due to internal tides might also upwell nutrients at the surface at a frequency similar to the tidal frequencies. Implications for biogeochemical modelling are important. Copyright © 2017 Elsevier Ltd. All rights reserved.

Influence of an asymmetric ring on the modeling of an orthogonally stiffened cylindrical shell

NASA Technical Reports Server (NTRS)

Rastogi, Naveen; Johnson, Eric R.

1994-01-01

Structural models are examined for the influence of a ring with an asymmetrical cross section on the linear elastic response of an orthogonally stiffened cylindrical shell subjected to internal pressure. The first structural model employs classical theory for the shell and stiffeners. The second model employs transverse shear deformation theories for the shell and stringer and classical theory for the ring. Closed-end pressure vessel effects are included. Interacting line load intensities are computed in the stiffener-to-skin joints for an example problem having the dimensions of the fuselage of a large transport aircraft. Classical structural theory is found to exaggerate the asymmetric response compared to the transverse shear deformation theory.

A kinematically driven anisotropic viscoelastic constitutive model applied to tires

NASA Technical Reports Server (NTRS)

Johnson, Arthur R.; Tanner, John A.; Mason, Angela J.

1995-01-01

Aircraft tires are composite structures manufactured with viscoelastic materials such as carbon black filled rubber and nylon cords. When loaded they experience large deflections and moderately large strains. Detailed structural models of tires require the use of either nonlinear shell or nonlinear three dimensional solid finite elements. Computational predictions of the dynamic response of tires must consider the composite viscoelastic material behavior in a realistic fashion. We describe a modification to a nonlinear anisotropic shell finite element so it can be used to model viscoelastic stresses during general deformations. The model is developed by introducing internal variables of the type used to model elastic strain energy. The internal variables are strains, curvatures, and transverse shear angles which are in a one-to-one correspondence with the generalized coordinates used to model the elastic strain energy for nonlinear response. A difference-relaxation equation is used to relate changes in the observable strain field to changes in the internal strain field. The internal stress state is introduced into the equilibrium equations by converting it to nodal loads associated with the element's displacement degrees of freedom. In this form the tangent matrix in the Newton-Raphson solution algorithm is not modified from its form for the nonlinear statics problem. Only the gradient vector is modified and the modification is not computationally costly. The existing finite element model for the Space Shuttle nose gear tire is used to provide examples of the algorithm. In the first example, the tire's rim is displaced at a constant rate up to a fixed value. In the second example, the tire's rim is enforced to follow a saw tooth load and unload curve to generate hysteresis loops.

A kinematically driven anisotropic viscoelastic constitutive model applied to tires

NASA Astrophysics Data System (ADS)

Johnson, Arthur R.; Tanner, John A.; Mason, Angela J.

1995-08-01

Aircraft tires are composite structures manufactured with viscoelastic materials such as carbon black filled rubber and nylon cords. When loaded they experience large deflections and moderately large strains. Detailed structural models of tires require the use of either nonlinear shell or nonlinear three dimensional solid finite elements. Computational predictions of the dynamic response of tires must consider the composite viscoelastic material behavior in a realistic fashion. We describe a modification to a nonlinear anisotropic shell finite element so it can be used to model viscoelastic stresses during general deformations. The model is developed by introducing internal variables of the type used to model elastic strain energy. The internal variables are strains, curvatures, and transverse shear angles which are in a one-to-one correspondence with the generalized coordinates used to model the elastic strain energy for nonlinear response. A difference-relaxation equation is used to relate changes in the observable strain field to changes in the internal strain field. The internal stress state is introduced into the equilibrium equations by converting it to nodal loads associated with the element's displacement degrees of freedom. In this form the tangent matrix in the Newton-Raphson solution algorithm is not modified from its form for the nonlinear statics problem. Only the gradient vector is modified and the modification is not computationally costly. The existing finite element model for the Space Shuttle nose gear tire is used to provide examples of the algorithm. In the first example, the tire's rim is displaced at a constant rate up to a fixed value. In the second example, the tire's rim is enforced to follow a saw tooth load and unload curve to generate hysteresis loops.

The Standard Model in noncommutative geometry: fundamental fermions as internal forms

NASA Astrophysics Data System (ADS)

Dąbrowski, Ludwik; D'Andrea, Francesco; Sitarz, Andrzej

2018-05-01

Given the algebra, Hilbert space H, grading and real structure of the finite spectral triple of the Standard Model, we classify all possible Dirac operators such that H is a self-Morita equivalence bimodule for the associated Clifford algebra.

German Validation of the Conners 3® Rating Scales for Parents, Teachers, and Children.

PubMed

Christiansen, Hanna; Hirsch, Oliver; Drechsler, Renate; Wanderer, Sina; Knospe, Eva-Lotte; Günther, Thomas; Lidzba, Karen

2016-01-01

Attention-deficit/hyperactivity disorder (ADHD) rating scales such as the Conners’ Rating Scales (CRS) are valuable adjuncts for diagnosis, since they offer parent, teacher, and self-ratings of children susceptible for ADHD. Even though the scales are widely used internationally, cross-cultural comparability has rarely been verified, and culture and language invariance have only been presumed. The Conners 3(®) rating scales are the updated version of the CRS, though hardly any studies report the psychometric properties apart from the results published in the test edition itself. To our knowledge there are no studies on the various adaptations of the Conners 3(®) in other languages. The German translations of the Conners 3(®) were completed by 745 children, 953 parents, and 741 teachers (children’s age range: 6–18 years, mean: 11.74 years of age). Exploratory and confirmatory factor analyses on content scale items were conducted to obtain the factor structure for the German version and to replicate the factor structure of the original American models. Cronbach’s α was calculated to establish internal consistency. The exploratory analyses for the German model resulted in factor structures globally different from the American model, though confirmatory analyses revealed very good model fi ts with highly satisfying Cronbach’s αs. We were able to provide empirical evidence for the subscale Inattention which had only hypothetically been derived by Conners (2008). Even though the exploratory analyses resulted in different factor structures, the confirmatory analyses have such excellent psychometric properties that use of the German adaptation of the Conners 3(®) is justifi ed in international multicenter studies.

An Investigation of the Internal Structure of the Biggs Study Process Questionnaire.

ERIC Educational Resources Information Center

Watkins, David; Hattie, John

1980-01-01

Results of an Australian study of the Biggs Study Process Questionnaire (SPQ) are presented. The purposes of the research were to: (1) re-examine the SPQ's internal consistency; (2) explore dimensionality of the SPQ scales; and (3) investigate validity of Bigg's model of the study process complex through factor analysis. (Author/GK)

Risky Sexual Behavior in Gay and Bisexual Men: Internalized Heterosexism, Sensation Seeking, and Substance Use

ERIC Educational Resources Information Center

Kashubeck-West, Susan; Szymanski, Dawn M.

2008-01-01

This study investigated risky sexual behavior in a sample of 209 gay and bisexual men. Using structural equation modeling, the mediating relations of substance use factors (expectations about the sexually enhancing effects of substance use and substance use during sex) between internalized heterosexism (IH) and sensation seeking and unprotected…

The Teachers' Sense of Efficacy Scale: Confirming the Factor Structure with Beginning Pre-Service Teachers

ERIC Educational Resources Information Center

Duffin, Lisa C.; French, Brian F.; Patrick, Helen

2012-01-01

This study examined the factor structure of the Teachers' Sense of Efficacy Scale (TSES; Tschannen-Moran & Woolfolk Hoy, 2001) using the scores of pre-service teachers at the beginning stage of teacher development to gather internal structure score validity evidence. Two plausible rival models derived from prior research were tested using CFA.…

Modeling Functional Neuroanatomy for an Anatomy Information System

PubMed Central

Niggemann, Jörg M.; Gebert, Andreas; Schulz, Stefan

2008-01-01

Objective Existing neuroanatomical ontologies, databases and information systems, such as the Foundational Model of Anatomy (FMA), represent outgoing connections from brain structures, but cannot represent the “internal wiring” of structures and as such, cannot distinguish between different independent connections from the same structure. Thus, a fundamental aspect of Neuroanatomy, the functional pathways and functional systems of the brain such as the pupillary light reflex system, is not adequately represented. This article identifies underlying anatomical objects which are the source of independent connections (collections of neurons) and uses these as basic building blocks to construct a model of functional neuroanatomy and its functional pathways. Design The basic representational elements of the model are unnamed groups of neurons or groups of neuron segments. These groups, their relations to each other, and the relations to the objects of macroscopic anatomy are defined. The resulting model can be incorporated into the FMA. Measurements The capabilities of the presented model are compared to the FMA and the Brain Architecture Management System (BAMS). Results Internal wiring as well as functional pathways can correctly be represented and tracked. Conclusion This model bridges the gap between representations of single neurons and their parts on the one hand and representations of spatial brain structures and areas on the other hand. It is capable of drawing correct inferences on pathways in a nervous system. The object and relation definitions are related to the Open Biomedical Ontology effort and its relation ontology, so that this model can be further developed into an ontology of neuronal functional systems. PMID:18579841

Electromagnetic Scattering Analysis of Large Size Asteroids/Comets for Reflection/Transmission Tomography (RTT)

NASA Technical Reports Server (NTRS)

Deshpande, Manohar

2011-01-01

A precise knowledge of the interior structure of asteroids, comets, and Near Earth Objects (NEO) is important to assess the consequences of their impacts with the Earth and develop efficient mitigation strategies. Knowledge of their interior structure also provides opportunities for extraction of raw materials for future space activities. Low frequency radio sounding is often proposed for investigating interior structures of asteroids and NEOs. For designing and optimizing radio sounding instrument it is advantageous to have an accurate and efficient numerical simulation model of radio reflection and transmission through large size bodies of asteroid shapes. In this presentation we will present electromagnetic (EM) scattering analysis of electrically large size asteroids using (1) a weak form formulation and (2) also a more accurate hybrid finite element method/method of moments (FEM/MOM) to help estimate their internal structures. Assuming the internal structure with known electrical properties of a sample asteroid, we first develop its forward EM scattering model. From the knowledge of EM scattering as a function of frequency and look angle we will then present the inverse scattering procedure to extract its interior structure image. Validity of the inverse scattering procedure will be presented through few simulation examples.

Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).

PubMed

Park, HaJeung; González, Àlex L; Yildirim, Ilyas; Tran, Tuan; Lohman, Jeremy R; Fang, Pengfei; Guo, Min; Disney, Matthew D

2015-06-23

Spinocerebellar ataxia type 10 (SCA10) is caused by a pentanucleotide repeat expansion of r(AUUCU) within intron 9 of the ATXN10 pre-mRNA. The RNA causes disease by a gain-of-function mechanism in which it inactivates proteins involved in RNA biogenesis. Spectroscopic studies showed that r(AUUCU) repeats form a hairpin structure; however, there were no high-resolution structural models prior to this work. Herein, we report the first crystal structure of model r(AUUCU) repeats refined to 2.8 Å and analysis of the structure via molecular dynamics simulations. The r(AUUCU) tracts adopt an overall A-form geometry in which 3 × 3 nucleotide (5')UCU(3')/(3')UCU(5') internal loops are closed by AU pairs. Helical parameters of the refined structure as well as the corresponding electron density map on the crystallographic model reflect dynamic features of the internal loop. The computational analyses captured dynamic motion of the loop closing pairs, which can form single-stranded conformations with relatively low energies. Overall, the results presented here suggest the possibility for r(AUUCU) repeats to form metastable A-from structures, which can rearrange into single-stranded conformations and attract proteins such as heterogeneous nuclear ribonucleoprotein K (hnRNP K). The information presented here may aid in the rational design of therapeutics targeting this RNA.

Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10)

PubMed Central

Park, HaJeung; González, Àlex L.; Yildirim, Ilyas; Tran, Tuan; Lohman, Jeremy R.; Fang, Pengfei; Guo, Min; Disney, Matthew D.

2016-01-01

Spinocerebellar ataxia type 10 (SCA10) is caused by a pentanucleotide repeat expansion of r(AUUCU) within intron 9 of the ATXN10 pre-mRNA. The RNA causes disease by a gain-of-function mechanism in which it inactivates proteins involved in RNA biogenesis. Spectroscopic studies showed that r(AUUCU) repeats form a hairpin structure; however, there were no high-resolution structural models prior to this work. Herein, we report the first crystal structure of model r(AUUCU) repeats refined to 2.8 Å and analysis of the structure via molecular dynamics simulations. The r(AUUCU) tracts adopt an overall A-form geometry in which 3 × 3 nucleotide 5′UCU3′/3′UCU5′ internal loops are closed by AU pairs. Helical parameters of the refined structure as well as the corresponding electron density map on the crystallographic model reflect dynamic features of the internal loop. The computational analyses captured dynamic motion of the loop closing pairs, which can form single-stranded conformations with relatively low energies. Overall, the results presented here suggest the possibility for r(AUUCU) repeats to form metastable A-from structures, which can rearrange into single-stranded conformations and attract proteins such as heterogeneous nuclear ribonucleoprotein K (hnRNP K). The information presented here may aid in the rational design of therapeutics targeting this RNA. PMID:26039897

Individual- and Structural-Level Risk Factors for Suicide Attempts Among Transgender Adults.

PubMed

Perez-Brumer, Amaya; Hatzenbuehler, Mark L; Oldenburg, Catherine E; Bockting, Walter

2015-01-01

This study assessed individual (ie, internalized transphobia) and structural forms of stigma as risk factors for suicide attempts among transgender adults. Internalized transphobia was assessed through a 26-item scale including four dimensions: pride, passing, alienation, and shame. State-level structural stigma was operationalized as a composite index, including density of same-sex couples; proportion of Gay-Straight Alliances per public high school; 5 policies related to sexual orientation discrimination; and aggregated public opinion toward homosexuality. Multivariable logistic generalized estimating equation models assessed associations of interest among an online sample of transgender adults (N = 1,229) representing 48 states and the District of Columbia. Lower levels of structural stigma were associated with fewer lifetime suicide attempts (AOR 0.96, 95% CI 0.92-0.997), and a higher score on the internalized transphobia scale was associated with greater lifetime suicide attempts (AOR 1.18, 95% CI 1.04-1.33). Addressing stigma at multiple levels is necessary to reduce the vulnerability of suicide attempts among transgender adults.

The Development of Causal Structure without a Language Model

ERIC Educational Resources Information Center

Rissman, Lilia; Goldin-Meadow, Susan

2017-01-01

Across a diverse range of languages, children proceed through similar stages in their production of causal language: their initial verbs lack internal causal structure, followed by a period during which they produce causative overgeneralizations, indicating knowledge of a productive causative rule. We asked in this study whether a child not…

International Summer Institute in Surface Science (4th), (ISISS 1979).

DTIC Science & Technology

1980-07-09

Gold crystallites growing on KC1 substrates were found, under certain conditions during the coalescence stage, to form large, irregularly shaped, very...structure up to the interface. The next part gives results issued from structural models for the crystal-melt interface of monoatomic solids. The main

Three-dimensional radiation transfer modeling in a dicotyledon leaf

NASA Astrophysics Data System (ADS)

Govaerts, Yves M.; Jacquemoud, Stéphane; Verstraete, Michel M.; Ustin, Susan L.

1996-11-01

The propagation of light in a typical dicotyledon leaf is investigated with a new Monte Carlo ray-tracing model. The three-dimensional internal cellular structure of the various leaf tissues, including the epidermis, the palisade parenchyma, and the spongy mesophyll, is explicitly described. Cells of different tissues are assigned appropriate morphologies and contain realistic amounts of water and chlorophyll. Each cell constituent is characterized by an index of refraction and an absorption coefficient. The objective of this study is to investigate how the internal three-dimensional structure of the tissues and the optical properties of cell constituents control the reflectance and transmittance of the leaf. Model results compare favorably with laboratory observations. The influence of the roughness of the epidermis on the reflection and absorption of light is investigated, and simulation results confirm that convex cells in the epidermis focus light on the palisade parenchyma and increase the absorption of radiation.

Influence of internal channel geometry of gas turbine blade on flow structure and heat transfer

NASA Astrophysics Data System (ADS)

Szwaba, Ryszard; Kaczynski, Piotr; Telega, Janusz; Doerffer, Piotr

2017-12-01

This paper presents the study of the influence of channel geometry on the flow structure and heat transfer, and also their correlations on all the walls of a radial cooling passage model of a gas turbine blade. The investigations focus on the heat transfer and aerodynamic measurements in the channel, which is an accurate representation of the configuration used in aeroengines. Correlations for the heat transfer coefficient and the pressure drop used in the design of internal cooling passages are often developed from simplified models. It is important to note that real engine passages do not have perfect rectangular cross sections, but include a corner fillets, ribs with fillet radii and a special orientation. Therefore, this work provides detailed fluid flow and heat transfer data for a model of radial cooling geometry which has very realistic features.

METAPHOR: Programmer's guide, Version 1

NASA Technical Reports Server (NTRS)

Furchtgott, D. G.

1979-01-01

The internal structure of the Michigan Evaluation Aid for Perphormability (METAPHOR), an interactive software package to facilitate performability modeling and evaluation is described. Revised supplemented guides are prepared in order to maintain an up-to-date documentation of the system. Programmed tools to facilitate each step of performability model construction and model solution are given.

Travel in Time: Tradition to Technology. Proceedings of the 1985 ABC International Convention (Chicago, Illinois, October 1985).

ERIC Educational Resources Information Center

Bruno, Sam J., Ed.; Pettit, John D., Jr., Ed.

These conference proceedings contain the following 23 presentations: "Development of a Communication Skill Model Using Interpretive Structural Modeling" (Karen S. Nantz and Linda Gammill); "The Coincidence of Needs: An Inventional Model for Audience Analysis" (Gina Burchard); "A Computer Algorithm for Measuring Readability" (Terry D. Lundgren);…

Evaluating Mental Models in Mathematics: A Comparison of Methods

ERIC Educational Resources Information Center

Gogus, Aytac

2013-01-01

Cognitive scientists investigate mental models (how humans organize and structure knowledge in their minds) so as to understand human understanding of and interactions with the world. Cognitive and mental model research is concerned with internal conceptual systems that are not easily or directly observable. The goal of this research was to…

Using Student Ratings to Measure Quality of Teaching in Six European Countries

ERIC Educational Resources Information Center

Kyriakides, Leonidas; Creemers, Bert P. M.; Panayiotou, Anastasia; Vanlaar, Gudrun; Pfeifer, Michael; Cankar, Gašper; McMahon, Léan

2014-01-01

This paper argues for the value of using student ratings to measure quality of teaching. An international study to test the validity of the dynamic model of educational effectiveness was conducted. At classroom level, the model consists of eight factors relating to teacher behaviour: orientation, structuring, questioning, teaching modelling,…

[Factor structure of the German version of the BIS/BAS Scales in a population-based sample].

PubMed

Müller, A; Smits, D; Claes, L; de Zwaan, M

2013-02-01

The Behavioural Inhibition System/Behavioural Activation System Scale (BIS/BAS-Scales) developed by Carver and White 1 is a self-rating instrument to assess the dispositional sensitivity to punishment and reward. The present work aims to examine the factor structure of the German version of the BIS/BAS-Scales. In a large German population-based sample (n = 1881) the model fit of several factor models was tested by using confirmatory factor analyses. The best model fit was found for the 5-factor model with two BIS (anxiety, fear) and three BAS (drive, reward responsiveness, fun seeking) scales, whereas the BIS-fear, the BAS-reward responsiveness, and the BAS-fun seeking subscales showed low internal consistency. The BIS/BAS scales were negatively correlated with age, and women reported higher BIS subscale scores than men. Confirmatory factor analyses suggest a 5-factor model. However, due to the low internal reliability of some of the subscales the use of this model is questionable. © Georg Thieme Verlag KG Stuttgart · New York.

A model for process representation and synthesis. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Thomas, R. H.

1971-01-01

The problem of representing groups of loosely connected processes is investigated, and a model for process representation useful for synthesizing complex patterns of process behavior is developed. There are three parts, the first part isolates the concepts which form the basis for the process representation model by focusing on questions such as: What is a process; What is an event; Should one process be able to restrict the capabilities of another? The second part develops a model for process representation which captures the concepts and intuitions developed in the first part. The model presented is able to describe both the internal structure of individual processes and the interface structure between interacting processes. Much of the model's descriptive power derives from its use of the notion of process state as a vehicle for relating the internal and external aspects of process behavior. The third part demonstrates by example that the model for process representation is a useful one for synthesizing process behavior patterns. In it the model is used to define a variety of interesting process behavior patterns. The dissertation closes by suggesting how the model could be used as a semantic base for a very potent language extension facility.

Market structure and the role of consumer information in the physician services industry: an empirical test.

PubMed

Wong, H S

1996-04-01

This paper applies Panzar and Rosse's (1987) econometric test of market structure to examine two long-debated issues: What is the market structure for physician services? Do more physicians in a market area raise the search cost of obtaining consumer information and increase prices (Satterthwaite, 1979, 1985)? For primary care and general and family practice physicians, the monopolistically competitive model prevailed over the competing hypotheses--monopoly, perfect competition, and monopolistic competition characterized by consumer informational confusion. Although less conclisive, there is some evidence to support the monopolistically competitive model for surgeons and the consumer informational confusion model for internal medicine physicians.

Reassessment of the psychometric characteristics and factor structure of the 'Perceived Stress Questionnaire' (PSQ): analysis in a sample of dental students.

PubMed

Montero-Marin, Jesús; Piva Demarzo, Marcelo Marcos; Pereira, Joao Paulo; Olea, Marina; García-Campayo, Javier

2014-01-01

The training to become a dentist can create psychological distress. The present study evaluates the structure of the 'Perceived Stress Questionnaire' (PSQ), its internal consistency model and interrelatedness with burnout, anxiety, depression and resilience among dental students. The study employed a cross-sectional design. A sample of Spanish dental students (n = 314) completed the PSQ, the 'Goldberg Anxiety and Depression Scale' (GADS), 'Connor-Davidson Resilience Scale' (10-item CD-RISC) and 'Maslach Burnout Inventory-Student Survey' (MBI-SS). The structure was estimated using Parallel Analysis from polychoric correlations. Unweighted Least Squares was the method for factor extraction, using the Item Response Theory to evaluate the discriminative power of items. Internal consistency was assessed by squaring the correlation between the latent true variable and the observed variable. The relationships between the PSQ and the other constructs were analysed using Spearman's coefficient. The results showed a PSQ structure through two sub-factors ('frustration' and 'tenseness') with regard to one general factor ('perceived stress'). Items that did not satisfy discriminative capacity were rejected. The model fit were acceptable (GFI = 0.98; RSMR = 0.06; AGFI = 0.98; NFI = 0.98; RFI = 0.98). All the factors showed adequate internal consistency as measured by the congeneric model (≥0.91). High and significant associations were observed between perceived stress and burnout, anxiety, depression and resilience. The PSQ showed a hierarchical bi-factor structure among Spanish dental students. Using the questionnaire as a uni-dimensional scale may be useful in perceived stress level discrimination, while the sub-factors could help us to refine perceived stress analysis and improve therapeutic processes.

Reassessment of the Psychometric Characteristics and Factor Structure of the ‘Perceived Stress Questionnaire’ (PSQ): Analysis in a Sample of Dental Students

PubMed Central

Montero-Marin, Jesús; Piva Demarzo, Marcelo Marcos; Pereira, Joao Paulo; Olea, Marina; García-Campayo, Javier

2014-01-01

Background The training to become a dentist can create psychological distress. The present study evaluates the structure of the ‘Perceived Stress Questionnaire’ (PSQ), its internal consistency model and interrelatedness with burnout, anxiety, depression and resilience among dental students. Methods The study employed a cross-sectional design. A sample of Spanish dental students (n = 314) completed the PSQ, the ‘Goldberg Anxiety and Depression Scale’ (GADS), ‘Connor-Davidson Resilience Scale’ (10-item CD-RISC) and ‘Maslach Burnout Inventory-Student Survey’ (MBI-SS). The structure was estimated using Parallel Analysis from polychoric correlations. Unweighted Least Squares was the method for factor extraction, using the Item Response Theory to evaluate the discriminative power of items. Internal consistency was assessed by squaring the correlation between the latent true variable and the observed variable. The relationships between the PSQ and the other constructs were analysed using Spearman’s coefficient. Results The results showed a PSQ structure through two sub-factors (‘frustration’ and ‘tenseness’) with regard to one general factor (‘perceived stress’). Items that did not satisfy discriminative capacity were rejected. The model fit were acceptable (GFI = 0.98; RSMR = 0.06; AGFI = 0.98; NFI = 0.98; RFI = 0.98). All the factors showed adequate internal consistency as measured by the congeneric model (≥0.91). High and significant associations were observed between perceived stress and burnout, anxiety, depression and resilience. Conclusions The PSQ showed a hierarchical bi-factor structure among Spanish dental students. Using the questionnaire as a uni-dimensional scale may be useful in perceived stress level discrimination, while the sub-factors could help us to refine perceived stress analysis and improve therapeutic processes. PMID:24466330

Imaging Internal Structure of Long Bones Using Wave Scattering Theory.

PubMed

Zheng, Rui; Le, Lawrence H; Sacchi, Mauricio D; Lou, Edmond

2015-11-01

An ultrasonic wavefield imaging method is developed to reconstruct the internal geometric properties of long bones using zero-offset data acquired axially on the bone surface. The imaging algorithm based on Born scattering theory is implemented with the conjugate gradient iterative method to reconstruct an optimal image. In the case of a multilayered velocity model, ray tracing through a smooth medium is used to calculate the traveled distance and traveling time. The method has been applied to simulated and real data. The results indicate that the interfaces of the top cortex are accurately imaged and correspond favorably to the original model. The reconstructed bottom cortex below the marrow is less accurate mainly because of the low signal-to-noise ratio. The current imaging method has successfully recovered the top cortical layer, providing a potential tool to investigate the internal structures of long bone cortex for osteoporosis assessment. Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Structure-based predictions of 13C-NMR chemical shifts for a series of 2-functionalized 5-(methylsulfonyl)-1-phenyl-1H-indoles derivatives using GA-based MLR method

NASA Astrophysics Data System (ADS)

Ghavami, Raouf; Sadeghi, Faridoon; Rasouli, Zolikha; Djannati, Farhad

2012-12-01

Experimental values for the 13C NMR chemical shifts (ppm, TMS = 0) at 300 K ranging from 96.28 ppm (C4' of indole derivative 17) to 159.93 ppm (C4' of indole derivative 23) relative to deuteride chloroform (CDCl3, 77.0 ppm) or dimethylsulfoxide (DMSO, 39.50 ppm) as internal reference in CDCl3 or DMSO-d6 solutions have been collected from literature for thirty 2-functionalized 5-(methylsulfonyl)-1-phenyl-1H-indole derivatives containing different substituted groups. An effective quantitative structure-property relationship (QSPR) models were built using hybrid method combining genetic algorithm (GA) based on stepwise selection multiple linear regression (SWS-MLR) as feature-selection tools and correlation models between each carbon atom of indole derivative and calculated descriptors. Each compound was depicted by molecular structural descriptors that encode constitutional, topological, geometrical, electrostatic, and quantum chemical features. The accuracy of all developed models were confirmed using different types of internal and external procedures and various statistical tests. Furthermore, the domain of applicability for each model which indicates the area of reliable predictions was defined.

Psychometric properties of the Brief Symptom Inventory-18 in a Spanish breast cancer sample.

PubMed

Galdón, Ma José; Durá, Estrella; Andreu, Yolanda; Ferrando, Maite; Murgui, Sergio; Pérez, Sandra; Ibañez, Elena

2008-12-01

The objective of this work was to study the psychometric and structural properties of the Brief Symptom Inventory-18 (BSI-18) in a sample of breast cancer patients (N=175). Confirmatory factor analyses were conducted. Two models were tested: the theoretical model with the original structure (three-dimensional), and the empirical model (a four-factor structure) obtained through exploratory factor analysis initially performed by the authors of the BSI-18. The eligible structure was the original proposal consisting of three dimensions: somatization, depression, and anxiety scores. These measures also showed good internal consistency. The results of this study support the reliability and structural validity of the BSI-18 as a standardized instrument for screening purposes in breast cancer patients, with the added benefits of simplicity and ease of application.

Does Competence Mediate the Associations between Puberty and Internalizing or Externalizing Problems in Adolescent Girls

PubMed Central

Negriff, Sonya; Hillman, Jennifer, B.; Dorn, Lorah D.

2011-01-01

Purpose To examine separate mediational models linking a) menarcheal status or b) pubertal timing to internalizing and externalizing problems through competence. Method Cross-sectional analyses of 262 adolescent girls (11–17 years; M=14.93, SD=2.17) enrolled in a longitudinal study examining the association of psychological functioning and smoking with reproductive and bone health. Measures of menarcheal status (pre/post), pubertal timing (early, on-time, or late), internalizing and externalizing behavior, and perceived competence (parent and adolescent report) were obtained. Structural Equation Modeling was used for analyses. Results Perceived competence was found to fully mediate the association between menarcheal status and parent report of internalizing and externalizing problems. For adolescent report, there was a full mediation effect for internalizing problems but a partial mediation effect for externalizing problems. Being menarcheal was related to lower competence which was related to higher internalizing and externalizing problems. Models including pubertal timing were not significant. Conclusions Perceived competence is important in understanding the associations between menarcheal status and internalizing and externalizing problems. Interventions targeting competence, particularly in post-menarcheal girls, may reduce or prevent problem behaviors. PMID:21939864

The Model Parameter Estimation Experiment (MOPEX): Its structure, connection to other international initiatives and future directions

USGS Publications Warehouse

Wagener, T.; Hogue, T.; Schaake, J.; Duan, Q.; Gupta, H.; Andreassian, V.; Hall, A.; Leavesley, G.

2006-01-01

The Model Parameter Estimation Experiment (MOPEX) is an international project aimed at developing enhanced techniques for the a priori estimation of parameters in hydrological models and in land surface parameterization schemes connected to atmospheric models. The MOPEX science strategy involves: database creation, a priori parameter estimation methodology development, parameter refinement or calibration, and the demonstration of parameter transferability. A comprehensive MOPEX database has been developed that contains historical hydrometeorological data and land surface characteristics data for many hydrological basins in the United States (US) and in other countries. This database is being continuously expanded to include basins from various hydroclimatic regimes throughout the world. MOPEX research has largely been driven by a series of international workshops that have brought interested hydrologists and land surface modellers together to exchange knowledge and experience in developing and applying parameter estimation techniques. With its focus on parameter estimation, MOPEX plays an important role in the international context of other initiatives such as GEWEX, HEPEX, PUB and PILPS. This paper outlines the MOPEX initiative, discusses its role in the scientific community, and briefly states future directions.

2D MHD AND 1D HD MODELS OF A SOLAR FLARE—A COMPREHENSIVE COMPARISON OF THE RESULTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Falewicz, R.; Rudawy, P.; Murawski, K.

Without any doubt, solar flaring loops possess a multithread internal structure that is poorly resolved, and there are no means to observe heating episodes and thermodynamic evolution of the individual threads. These limitations cause fundamental problems in numerical modeling of flaring loops, such as selection of a structure and a number of threads, and an implementation of a proper model of the energy deposition process. A set of one-dimensional (1D) hydrodynamic and two-dimensional (2D) magnetohydrodynamic models of a flaring loop are developed to compare energy redistribution and plasma dynamics in the course of a prototypical solar flare. Basic parameters ofmore » the modeled loop are set according to the progenitor M1.8 flare recorded in AR 10126 on 2002 September 20 between 09:21 UT and 09:50 UT. The nonideal 1D models include thermal conduction and radiative losses of the optically thin plasma as energy-loss mechanisms, while the nonideal 2D models take into account viscosity and thermal conduction as energy-loss mechanisms only. The 2D models have a continuous distribution of the parameters of the plasma across the loop and are powered by varying in time and space along and across the loop heating flux. We show that such 2D models are an extreme borderline case of a multithread internal structure of the flaring loop, with a filling factor equal to 1. Nevertheless, these simple models ensure the general correctness of the obtained results and can be adopted as a correct approximation of the real flaring structures.« less

Point process models for localization and interdependence of punctate cellular structures.

PubMed

Li, Ying; Majarian, Timothy D; Naik, Armaghan W; Johnson, Gregory R; Murphy, Robert F

2016-07-01

Accurate representations of cellular organization for multiple eukaryotic cell types are required for creating predictive models of dynamic cellular function. To this end, we have previously developed the CellOrganizer platform, an open source system for generative modeling of cellular components from microscopy images. CellOrganizer models capture the inherent heterogeneity in the spatial distribution, size, and quantity of different components among a cell population. Furthermore, CellOrganizer can generate quantitatively realistic synthetic images that reflect the underlying cell population. A current focus of the project is to model the complex, interdependent nature of organelle localization. We built upon previous work on developing multiple non-parametric models of organelles or structures that show punctate patterns. The previous models described the relationships between the subcellular localization of puncta and the positions of cell and nuclear membranes and microtubules. We extend these models to consider the relationship to the endoplasmic reticulum (ER), and to consider the relationship between the positions of different puncta of the same type. Our results do not suggest that the punctate patterns we examined are dependent on ER position or inter- and intra-class proximity. With these results, we built classifiers to update previous assignments of proteins to one of 11 patterns in three distinct cell lines. Our generative models demonstrate the ability to construct statistically accurate representations of puncta localization from simple cellular markers in distinct cell types, capturing the complex phenomena of cellular structure interaction with little human input. This protocol represents a novel approach to vesicular protein annotation, a field that is often neglected in high-throughput microscopy. These results suggest that spatial point process models provide useful insight with respect to the spatial dependence between cellular structures. © 2016 International Society for Advancement of Cytometry. © 2016 International Society for Advancement of Cytometry.

Effects of state recovery on creep buckling under variable loading

NASA Technical Reports Server (NTRS)

Robinson, D. N.; Arnold, S. M.

1986-01-01

Structural alloys embody internal mechanisms that allow recovery of state with varying stress and elevated temperature, i.e., they can return to a softer state following periods of hardening. Such material behavior is known to strongly influence structural response under some important thermomechanical loadings, for example, that involving thermal ratchetting. The influence of dynamic and thermal recovery on the creep buckling of a column under variable loading is investigated. The column is taken as the idealized (Shanley) sandwich column. The constitutive model, unlike the commonly employed Norton creep model, incorporates a representation of both dynamic and thermal (state) recovery. The material parameters of the constitutive model are chosen to characterize Narloy Z, a representative copper alloy used in thrust nozzle liners of reusable rocket engines. Variable loading histories include rapid cyclic unloading/reloading sequences and intermittent reductions of load for extended periods of time; these are superimposed on a constant load. The calculated results show that state recovery significantly affects creep buckling under variable loading. Structural alloys embody internal mechanisms that allow recovery of state with varying stress and time.

Explaining the trade-growth link: Assessing diffusion-based and structure-based models of exchange.

PubMed

Clark, Rob; Mahutga, Matthew C

2013-03-01

International development scholars advance contrasting theoretical explanations for the hypothesized link between trade and growth. Diffusion-based models suggest that trade with integrated partners provides states with greater access to technical knowledge. Structure-based models propose that trading with isolated partners produces a bargaining advantage. In this study, we adjudicate between these competing visions by applying Bonacich's (1987) measure of power centrality to the international trade network. We manipulate the procedure's "attenuation factor" (β) such that a state's trade centrality can be enhanced when a state is connected to either central or isolated partners. Drawing from a sample of 101 states during the 1980-2000 period, we use difference-of-logs models to assess the impact of trade centrality on economic growth net of controls. We find that the positive relationship between trade centrality and growth peaks when states trade with isolated partners in the periphery. Copyright © 2012 Elsevier Inc. All rights reserved.

Unification theory of optimal life histories and linear demographic models in internal stochasticity.

PubMed

Oizumi, Ryo

2014-01-01

Life history of organisms is exposed to uncertainty generated by internal and external stochasticities. Internal stochasticity is generated by the randomness in each individual life history, such as randomness in food intake, genetic character and size growth rate, whereas external stochasticity is due to the environment. For instance, it is known that the external stochasticity tends to affect population growth rate negatively. It has been shown in a recent theoretical study using path-integral formulation in structured linear demographic models that internal stochasticity can affect population growth rate positively or negatively. However, internal stochasticity has not been the main subject of researches. Taking account of effect of internal stochasticity on the population growth rate, the fittest organism has the optimal control of life history affected by the stochasticity in the habitat. The study of this control is known as the optimal life schedule problems. In order to analyze the optimal control under internal stochasticity, we need to make use of "Stochastic Control Theory" in the optimal life schedule problem. There is, however, no such kind of theory unifying optimal life history and internal stochasticity. This study focuses on an extension of optimal life schedule problems to unify control theory of internal stochasticity into linear demographic models. First, we show the relationship between the general age-states linear demographic models and the stochastic control theory via several mathematical formulations, such as path-integral, integral equation, and transition matrix. Secondly, we apply our theory to a two-resource utilization model for two different breeding systems: semelparity and iteroparity. Finally, we show that the diversity of resources is important for species in a case. Our study shows that this unification theory can address risk hedges of life history in general age-states linear demographic models.

Unification Theory of Optimal Life Histories and Linear Demographic Models in Internal Stochasticity

PubMed Central

Oizumi, Ryo

2014-01-01

Life history of organisms is exposed to uncertainty generated by internal and external stochasticities. Internal stochasticity is generated by the randomness in each individual life history, such as randomness in food intake, genetic character and size growth rate, whereas external stochasticity is due to the environment. For instance, it is known that the external stochasticity tends to affect population growth rate negatively. It has been shown in a recent theoretical study using path-integral formulation in structured linear demographic models that internal stochasticity can affect population growth rate positively or negatively. However, internal stochasticity has not been the main subject of researches. Taking account of effect of internal stochasticity on the population growth rate, the fittest organism has the optimal control of life history affected by the stochasticity in the habitat. The study of this control is known as the optimal life schedule problems. In order to analyze the optimal control under internal stochasticity, we need to make use of “Stochastic Control Theory” in the optimal life schedule problem. There is, however, no such kind of theory unifying optimal life history and internal stochasticity. This study focuses on an extension of optimal life schedule problems to unify control theory of internal stochasticity into linear demographic models. First, we show the relationship between the general age-states linear demographic models and the stochastic control theory via several mathematical formulations, such as path–integral, integral equation, and transition matrix. Secondly, we apply our theory to a two-resource utilization model for two different breeding systems: semelparity and iteroparity. Finally, we show that the diversity of resources is important for species in a case. Our study shows that this unification theory can address risk hedges of life history in general age-states linear demographic models. PMID:24945258

Methods for computing internal flattening, with applications to the Earth's structure and geodynamics

NASA Astrophysics Data System (ADS)

Denis, C.; Amalvict, M.; Rogister, Y.; Tomecka-Suchoń, S.

1998-03-01

After general comments (Section 1) on using variational procedures to compute the oblateness of internal strata in the Earth and slowly rotating planets, we recall briefly some basic concepts about barotropic equilibrium figures (Section 2), and then proceed to discuss several accurate methods to derive the internal flattening. The algorithms given in Section 3 are based on the internal gravity field theory of Clairaut, Laplace and Lyapunov. They make explicit use of the concept of a level surface. The general formulation given here leads to a number of formulae which are of both theoretical and practical use in studying the Earth's structure, dynamics and rotational evolution. We provide exact solutions for the figure functions of three Earth models, and apply the formalism to yield curves for the internal flattening as a function of the spin frequency. Two more methods, which use the general deformation equations, are discussed in Section 4. The latter do not rely explicitly on the existence of level surfaces. They offer an alternative to the classical first-order internal field theory, and can actually be used to compute changes of the flattening on short timescales produced by variations in the LOD. For short durations, the Earth behaves elastically rather than hydrostatically. We discuss in some detail static deformations and Longman's static core paradox (Section 5), and demonstrate that in general no static solution exists for a realistic Earth model. In Section 6 we deal briefly with differential rotation occurring in cylindrical shells, and show why differential rotation of the inner core such as has been advocated recently is incompatible with the concept of level surfaces. In Section 7 we discuss first-order hydrostatic theory in relation to Earth structure, and show how to derive a consistent reference Earth model which is more suitable for geodynamical modelling than are modern Earth models such as 1066-A, PREM or CORE11. An important result is that a consistent application of hydrostatic theory leads to an inertia factor of about 0.332 instead of the value 0.3308 used until now. This change automatically brings `hydrostatic' values of the flattening, the dynamic shape factor and the precessional constant into much better agreement with their observed counterparts than has been assumed hitherto. Of course, we do not imply that non-hydrostatic effects are unimportant in modelling geodynamic processes. Finally, we discuss (Sections 7-8) some implications of our way of looking at things for Earth structure and some current problems of geodynamics. We suggest very significant changes for the structure of the core, in particular a strong reduction of the density jump at the inner core boundary. The theoretical value of the free core nutation period, which may be computed by means of our hydrostatic Earth models CGGM or PREMM, is in somewhat better agreement with the observed value than that based on PREM or 1066-A, although a significant residue remains. We attribute the latter to inadequate modelling of the deformation, and hence of the change in the inertia tensor, because the static deformation equations were used. We argue that non-hydrostatic effects, though present, cannot explain the large observed discrepancy of about 30 days.

Vehicle active steering control research based on two-DOF robust internal model control

NASA Astrophysics Data System (ADS)

Wu, Jian; Liu, Yahui; Wang, Fengbo; Bao, Chunjiang; Sun, Qun; Zhao, Youqun

2016-07-01

Because of vehicle's external disturbances and model uncertainties, robust control algorithms have obtained popularity in vehicle stability control. The robust control usually gives up performance in order to guarantee the robustness of the control algorithm, therefore an improved robust internal model control(IMC) algorithm blending model tracking and internal model control is put forward for active steering system in order to reach high performance of yaw rate tracking with certain robustness. The proposed algorithm inherits the good model tracking ability of the IMC control and guarantees robustness to model uncertainties. In order to separate the design process of model tracking from the robustness design process, the improved 2 degree of freedom(DOF) robust internal model controller structure is given from the standard Youla parameterization. Simulations of double lane change maneuver and those of crosswind disturbances are conducted for evaluating the robust control algorithm, on the basis of a nonlinear vehicle simulation model with a magic tyre model. Results show that the established 2-DOF robust IMC method has better model tracking ability and a guaranteed level of robustness and robust performance, which can enhance the vehicle stability and handling, regardless of variations of the vehicle model parameters and the external crosswind interferences. Contradiction between performance and robustness of active steering control algorithm is solved and higher control performance with certain robustness to model uncertainties is obtained.

Test and Analysis Correlation of High Speed Impacts of Ice Cylinders

NASA Technical Reports Server (NTRS)

Fasanella, Edwin L.; Boitnott, Richard L.; Kellas, Sotiris

2006-01-01

During the space shuttle return-to-flight preparations following the Columbia accident, finite element models were needed that could predict the threshold of critical damage to the orbiter s wing leading edge from ice debris impacts. Hence, an experimental program was initiated to provide crushing data from impacted ice for use in dynamic finite element material models. A high-speed drop tower was configured to capture force time-histories of ice cylinders for impacts up to approximately 100 ft/s. At low velocity, the force-time history depended heavily on the internal crystalline structure of the ice. However, for velocities of 100 ft/s and above, the ice fractured on impact, behaved more like a fluid, and the subsequent force-time history curves were much less dependent on the internal crystalline structure.

Dynamic Crush Characterization of Ice

NASA Technical Reports Server (NTRS)

Fasanella, Edwin L.; Boitnott, Richard L.; Kellas, Sotiris

2006-01-01

During the space shuttle return-to-flight preparations following the Columbia accident, finite element models were needed that could predict the threshold of critical damage to the orbiter's wing leading edge from ice debris impacts. Hence, an experimental program was initiated to provide crushing data from impacted ice for use in dynamic finite element material models. A high-speed drop tower was configured to capture force time histories of ice cylinders for impacts up to approximately 100 ft/s. At low velocity, the force-time history depended heavily on the internal crystalline structure of the ice. However, for velocities of 100 ft/s and above, the ice fractured on impact, behaved more like a fluid, and the subsequent force-time history curves were much less dependent on the internal crystalline structure.

Effects of varying obliquity on Martian sublimation thermokarst landforms

USGS Publications Warehouse

Dundas, Colin M.

2017-01-01

Scalloped depressions in the Martian mid-latitudes are likely formed by sublimation of ice-rich ground. The stability of subsurface ice changes with the planetary obliquity, generally becoming less stable at lower axial tilt. As a result, the relative rates of sublimation and creep change over time. A landscape evolution model shows that these variations produce internal structure in scalloped depressions, commonly in the form of arcuate ridges, which emerge as depressions resume growth after pausing or slowing. In other scenarios, the formation of internal structure is minimal. Significant uncertainties in past climate and model parameters permit a range of scenarios. Ridges observed in some Martian scalloped depressions could date from obliquity lows or periods of low ice stability occurring <5 Ma, suggesting that the pits are young features and may be actively evolving.

Loops determine the mechanical properties of mitotic chromosomes

NASA Astrophysics Data System (ADS)

Zhang, Yang; Heermann, Dieter W.

2013-03-01

In mitosis, chromosomes undergo a condensation into highly compacted, rod-like objects. Many models have been put forward for the higher-order organization of mitotic chromosomes including radial loop and hierarchical folding models. Additionally, mechanical properties of mitotic chromosomes under different conditions were measured. However, the internal organization of mitotic chromosomes still remains unclear. Here we present a polymer model for mitotic chromosomes and show how chromatin loops play a major role for their mechanical properties. The key assumption of the model is the ability of the chromatin fibre to dynamically form loops with the help of binding proteins. Our results show that looping leads to a tight compaction and significantly increases the bending rigidity of chromosomes. Moreover, our qualitative prediction of the force elongation behaviour is close to experimental findings. This indicates that the internal structure of mitotic chromosomes is based on self-organization of the chromatin fibre. We also demonstrate how number and size of loops have a strong influence on the mechanical properties. We suggest that changes in the mechanical characteristics of chromosomes can be explained by an altered internal loop structure. YZ gratefully appreciates funding by the German National Academic Foundation (Studienstiftung des deutschen Volkes) and support by the Heidelberg Graduate School for Mathematical and Computational Methods in the Sciences (HGS MathComp).

Handling topological changes during elastic registration : Application to augmented reality in laparoscopic surgery.

PubMed

Paulus, Christoph J; Haouchine, Nazim; Kong, Seong-Ho; Soares, Renato Vianna; Cazier, David; Cotin, Stephane

2017-03-01

Locating the internal structures of an organ is a critical aspect of many surgical procedures. Minimally invasive surgery, associated with augmented reality techniques, offers the potential to visualize inner structures, allowing for improved analysis, depth perception or for supporting planning and decision systems. Most of the current methods dealing with rigid or non-rigid augmented reality make the assumption that the topology of the organ is not modified. As surgery relies essentially on cutting and dissection of anatomical structures, such methods are limited to the early stages of the surgery. We solve this shortcoming with the introduction of a method for physics-based elastic registration using a single view from a monocular camera. Singularities caused by topological changes are detected and propagated to the preoperative model. This significantly improves the coherence between the actual laparoscopic view and the model and provides added value in terms of navigation and decision-making, e.g., by overlaying the internal structures of an organ on the laparoscopic view. Our real-time augmentation method is assessed on several scenarios, using synthetic objects and real organs. In all cases, the impact of our approach is demonstrated, both qualitatively and quantitatively ( http://www.open-cas.org/?q=PaulusIJCARS16 ). The presented approach tackles the challenge of localizing internal structures throughout a complete surgical procedure, even after surgical cuts. This information is crucial for surgeons to improve the outcome for their surgical procedure and avoid complications.

A neurosurgical simulation of skull base tumors using a 3D printed rapid prototyping model containing mesh structures.

PubMed

Kondo, Kosuke; Harada, Naoyuki; Masuda, Hiroyuki; Sugo, Nobuo; Terazono, Sayaka; Okonogi, Shinichi; Sakaeyama, Yuki; Fuchinoue, Yutaka; Ando, Syunpei; Fukushima, Daisuke; Nomoto, Jun; Nemoto, Masaaki

2016-06-01

Deep regions are not visible in three-dimensional (3D) printed rapid prototyping (RP) models prepared from opaque materials, which is not the case with translucent images. The objectives of this study were to develop an RP model in which a skull base tumor was simulated using mesh, and to investigate its usefulness for surgical simulations by evaluating the visibility of its deep regions. A 3D printer that employs binder jetting and is mainly used to prepare plaster models was used. RP models containing a solid tumor, no tumor, and a mesh tumor were prepared based on computed tomography, magnetic resonance imaging, and angiographic data for four cases of petroclival tumor. Twelve neurosurgeons graded the three types of RP model into the following four categories: 'clearly visible,' 'visible,' 'difficult to see,' and 'invisible,' based on the visibility of the internal carotid artery, basilar artery, and brain stem through a craniotomy performed via the combined transpetrosal approach. In addition, the 3D positional relationships between these structures and the tumor were assessed. The internal carotid artery, basilar artery, and brain stem and the positional relationships of these structures with the tumor were significantly more visible in the RP models with mesh tumors than in the RP models with solid or no tumors. The deep regions of PR models containing mesh skull base tumors were easy to visualize. This 3D printing-based method might be applicable to various surgical simulations.

Psychometric Properties of the “Sport Motivation Scale (SMS)” Adapted to Physical Education

PubMed Central

Granero-Gallegos, Antonio; Baena-Extremera, Antonio; Gómez-López, Manuel; Sánchez-Fuentes, José Antonio; Abraldes, J. Arturo

2014-01-01

The aim of this study was to investigate the factor structure of a Spanish version of the Sport Motivation Scale adapted to physical education. A second aim was to test which one of three hypothesized models (three, five and seven-factor) provided best model fit. 758 Spanish high school students completed the Sport Motivation Scale adapted for Physical Education and also completed the Learning and Performance Orientation in Physical Education Classes Questionnaire. We examined the factor structure of each model using confirmatory factor analysis and also assessed internal consistency and convergent validity. The results showed that all three models in Spanish produce good indicators of fitness, but we suggest using the seven-factor model (χ2/gl = 2.73; ECVI = 1.38) as it produces better values when adapted to physical education, that five-factor model (χ2/gl = 2.82; ECVI = 1.44) and three-factor model (χ2/gl = 3.02; ECVI = 1.53). Key Points Physical education research conducted in Spain has used the version of SMS designed to assess motivation in sport, but validity reliability and validity results in physical education have not been reported. Results of the present study lend support to the factorial validity and internal reliability of three alternative factor structures (3, 5, and 7 factors) of SMS adapted to Physical Education in Spanish. Although all three models in Spanish produce good indicators of fitness, but we suggest using the seven-factor model. PMID:25435772

Intensive MHD-structures penetration in the middle atmosphere initiated in the ionospheric cusp under quiet geomagnetic conditions

NASA Technical Reports Server (NTRS)

Mateev, L. N.; Nenovski, P. I.; Vellinov, P. I.

1989-01-01

In connection with the recently detected quasiperiodical magnetic disturbances in the ionospheric cusp, the penetration of compressional surface magnetohydrodynamic (MHD) waves through the middle atmosphere is modelled numerically. For the COSPAR International Reference Atmosphere (CIRA) 72 model the respective energy density flux of the disturbances in the middle atmosphere is determined. On the basis of the developed model certain conclusions are reached about the height distribution of the structures (energy losses, currents, etc.) initiated by intensive magnetic cusp disturbances.

Geometric parameter analysis to predetermine optimal radiosurgery technique for the treatment of arteriovenous malformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mestrovic, Ante; Clark, Brenda G.; Department of Medical Physics, British Columbia Cancer Agency, Vancouver, British Columbia

2005-11-01

Purpose: To develop a method of predicting the values of dose distribution parameters of different radiosurgery techniques for treatment of arteriovenous malformation (AVM) based on internal geometric parameters. Methods and Materials: For each of 18 previously treated AVM patients, four treatment plans were created: circular collimator arcs, dynamic conformal arcs, fixed conformal fields, and intensity-modulated radiosurgery. An algorithm was developed to characterize the target and critical structure shape complexity and the position of the critical structures with respect to the target. Multiple regression was employed to establish the correlation between the internal geometric parameters and the dose distribution for differentmore » treatment techniques. The results from the model were applied to predict the dosimetric outcomes of different radiosurgery techniques and select the optimal radiosurgery technique for a number of AVM patients. Results: Several internal geometric parameters showing statistically significant correlation (p < 0.05) with the treatment planning results for each technique were identified. The target volume and the average minimum distance between the target and the critical structures were the most effective predictors for normal tissue dose distribution. The structure overlap volume with the target and the mean distance between the target and the critical structure were the most effective predictors for critical structure dose distribution. The predicted values of dose distribution parameters of different radiosurgery techniques were in close agreement with the original data. Conclusions: A statistical model has been described that successfully predicts the values of dose distribution parameters of different radiosurgery techniques and may be used to predetermine the optimal technique on a patient-to-patient basis.« less

Damage criticality and inspection concerns of composite-metallic aircraft structures under blunt impact

NASA Astrophysics Data System (ADS)

Zou, D.; Haack, C.; Bishop, P.; Bezabeh, A.

2015-04-01

Composite aircraft structures such as fuselage and wings are subject to impact from many sources. Ground service equipment (GSE) vehicles are regarded as realistic sources of blunt impact damage, where the protective soft rubber is used. With the use of composite materials, blunt impact damage is of special interest, since potential significant structural damage may be barely visible or invisible on the structure's outer surface. Such impact can result in local or non-local damage, in terms of internal delamination in skin, interfacial delamination between stiffeners and skin, and fracture of internal reinforced component such as stringers and frames. The consequences of these events result in aircraft damage, delays, and financial cost to the industry. Therefore, it is necessary to understand the criticality of damage under this impact and provide reliable recommendations for safety and inspection technologies. This investigation concerns a composite-metallic 4-hat-stiffened and 5-frame panel, designed to represent a fuselage structure panel generic to the new generation of composite aircraft. The test fixtures were developed based on the correlation between finite element analyses of the panel model and the barrel model. Three static tests at certain amount of impact energy were performed, in order to improve the understanding of the influence of the variation in shear ties, and the added rotational stiffness. The results of this research demonstrated low velocity high mass impacts on composite aircraft fuselages beyond 82.1 kN of impact load, which may cause extensive internal structural damage without clear visual detectability on the external skin surface.

Understanding the Organizational Context of Academic Program Development

ERIC Educational Resources Information Center

Dee, Jay R.; Heineman, William A.

2016-01-01

This chapter provides a conceptual model that academic leaders can use to navigate the complex, and often contentious, organizational terrain of academic program development. The model includes concepts related to the institution's external environment, as well as internal organizational structures, cultures, and politics. Drawing from the…

Isolating the anthropogenic component of Arctic warming

DOE PAGES

Chylek, Petr; Hengartner, Nicholas; Lesins, Glen; ...

2014-05-28

Structural equation modeling is used in statistical applications as both confirmatory and exploratory modeling to test models and to suggest the most plausible explanation for a relationship between the independent and the dependent variables. Although structural analysis cannot prove causation, it can suggest the most plausible set of factors that influence the observed variable. Here, we apply structural model analysis to the annual mean Arctic surface air temperature from 1900 to 2012 to find the most effective set of predictors and to isolate the anthropogenic component of the recent Arctic warming by subtracting the effects of natural forcing and variabilitymore » from the observed temperature. We also find that anthropogenic greenhouse gases and aerosols radiative forcing and the Atlantic Multidecadal Oscillation internal mode dominate Arctic temperature variability. Finally, our structural model analysis of observational data suggests that about half of the recent Arctic warming of 0.64 K/decade may have anthropogenic causes.« less

A Structured Approach for Reviewing Architecture Documentation

DTIC Science & Technology

2009-12-01

as those found in ISO 12207 [ ISO /IEC 12207 :2008] (for software engineering), ISO 15288 [ ISO /IEC 15288:2008] (for systems engineering), the Rational...Open Distributed Processing - Reference Model: Foundations ( ISO /IEC 10746-2). 1996. [ ISO /IEC 12207 :2008] International Organization for...Standardization & International Electrotechnical Commission. Sys- tems and software engineering – Software life cycle processes ( ISO /IEC 12207 ). 2008. [ ISO

Professional Learning Communities Assessment: Adaptation, Internal Validity, and Multidimensional Model Testing in Turkish Context

ERIC Educational Resources Information Center

Dogan, Selçuk; Tatik, R. Samil; Yurtseven, Nihal

2017-01-01

The main purpose of this study is to adapt and validate the Professional Learning Communities Assessment Revised (PLCA-R) by Olivier, Hipp, and Huffman within the context of Turkish schools. The instrument was translated and adapted to administer to teachers in Turkey. Internal structure of the Turkish version of PLCA-R was investigated by using…

Human and natural influences on the changing thermal structure of the atmosphere

PubMed Central

Santer, Benjamin D.; Painter, Jeffrey F.; Bonfils, Céline; Mears, Carl A.; Solomon, Susan; Wigley, Tom M. L.; Gleckler, Peter J.; Schmidt, Gavin A.; Doutriaux, Charles; Gillett, Nathan P.; Taylor, Karl E.; Thorne, Peter W.; Wentz, Frank J.

2013-01-01

Since the late 1970s, satellite-based instruments have monitored global changes in atmospheric temperature. These measurements reveal multidecadal tropospheric warming and stratospheric cooling, punctuated by short-term volcanic signals of reverse sign. Similar long- and short-term temperature signals occur in model simulations driven by human-caused changes in atmospheric composition and natural variations in volcanic aerosols. Most previous comparisons of modeled and observed atmospheric temperature changes have used results from individual models and individual observational records. In contrast, we rely on a large multimodel archive and multiple observational datasets. We show that a human-caused latitude/altitude pattern of atmospheric temperature change can be identified with high statistical confidence in satellite data. Results are robust to current uncertainties in models and observations. Virtually all previous research in this area has attempted to discriminate an anthropogenic signal from internal variability. Here, we present evidence that a human-caused signal can also be identified relative to the larger “total” natural variability arising from sources internal to the climate system, solar irradiance changes, and volcanic forcing. Consistent signal identification occurs because both internal and total natural variability (as simulated by state-of-the-art models) cannot produce sustained global-scale tropospheric warming and stratospheric cooling. Our results provide clear evidence for a discernible human influence on the thermal structure of the atmosphere. PMID:24043789

Scattering Properties of Large Irregular Cosmic Dust Particles at Visible Wavelengths

DOE Office of Scientific and Technical Information (OSTI.GOV)

Escobar-Cerezo, J.; Palmer, C.; Muñoz, O.

The effect of internal inhomogeneities and surface roughness on the scattering behavior of large cosmic dust particles is studied by comparing model simulations with laboratory measurements. The present work shows the results of an attempt to model a dust sample measured in the laboratory with simulations performed by a ray-optics model code. We consider this dust sample as a good analogue for interplanetary and interstellar dust as it shares its refractive index with known materials in these media. Several sensitivity tests have been performed for both structural cases (internal inclusions and surface roughness). Three different samples have been selected tomore » mimic inclusion/coating inhomogeneities: two measured scattering matrices of hematite and white clay, and a simulated matrix for water ice. These three matrices are selected to cover a wide range of imaginary refractive indices. The selection of these materials also seeks to study astrophysical environments of interest such as Mars, where hematite and clays have been detected, and comets. Based on the results of the sensitivity tests shown in this work, we perform calculations for a size distribution of a silicate-type host particle model with inclusions and surface roughness to reproduce the experimental measurements of a dust sample. The model fits the measurements quite well, proving that surface roughness and internal structure play a role in the scattering pattern of irregular cosmic dust particles.« less

Structural analysis of glycoproteins: building N-linked glycans with Coot.

PubMed

Emsley, Paul; Crispin, Max

2018-04-01

Coot is a graphics application that is used to build or manipulate macromolecular models; its particular forte is manipulation of the model at the residue level. The model-building tools of Coot have been combined and extended to assist or automate the building of N-linked glycans. The model is built by the addition of monosaccharides, placed by variation of internal coordinates. The subsequent model is refined by real-space refinement, which is stabilized with modified and additional restraints. It is hoped that these enhanced building tools will help to reduce building errors of N-linked glycans and improve our knowledge of the structures of glycoproteins.

Examination of simplified travel demand model. [Internal volume forecasting model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, R.L. Jr.; McFarlane, W.J.

1978-01-01

A simplified travel demand model, the Internal Volume Forecasting (IVF) model, proposed by Low in 1972 is evaluated as an alternative to the conventional urban travel demand modeling process. The calibration of the IVF model for a county-level study area in Central Wisconsin results in what appears to be a reasonable model; however, analysis of the structure of the model reveals two primary mis-specifications. Correction of the mis-specifications leads to a simplified gravity model version of the conventional urban travel demand models. Application of the original IVF model to ''forecast'' 1960 traffic volumes based on the model calibrated for 1970more » produces accurate estimates. Shortcut and ad hoc models may appear to provide reasonable results in both the base and horizon years; however, as shown by the IVF mode, such models will not always provide a reliable basis for transportation planning and investment decisions.« less

The curious case of Mercury's internal structure

NASA Astrophysics Data System (ADS)

Hauck, Steven A.; Margot, Jean-Luc; Solomon, Sean C.; Phillips, Roger J.; Johnson, Catherine L.; Lemoine, Frank G.; Mazarico, Erwan; McCoy, Timothy J.; Padovan, Sebastiano; Peale, Stanton J.; Perry, Mark E.; Smith, David E.; Zuber, Maria T.

2013-06-01

The recent determination of the gravity field of Mercury and new Earth-based radar observations of the planet's spin state afford the opportunity to explore Mercury's internal structure. These observations provide estimates of two measures of the radial mass distribution of Mercury: the normalized polar moment of inertia and the fractional polar moment of inertia of the solid portion of the planet overlying the liquid core. Employing Monte Carlo techniques, we calculate several million models of the radial density structure of Mercury consistent with its radius and bulk density and constrained by these moment of inertia parameters. We estimate that the top of the liquid core is at a radius of 2020 ± 30 km, the mean density above this boundary is 3380 ± 200 kg m-3, and the density below the boundary is 6980 ± 280 kg m-3. We find that these internal structure parameters are robust across a broad range of compositional models for the core and planet as a whole. Geochemical observations of Mercury's surface by MESSENGER indicate a chemically reducing environment that would favor the partitioning of silicon or both silicon and sulfur into the metallic core during core-mantle differentiation. For a core composed of Fe-S-Si materials, the thermodynamic properties at elevated pressures and temperatures suggest that an FeS-rich layer could form at the top of the core and that a portion of it may be presently solid.

Psychological and behavioral consequences of job loss: a covariance structure analysis using Weiner's (1985) attribution model.

PubMed

Prussia, G E; Kinicki, A J; Bracker, J S

1993-06-01

B. Weiner's (1985) attribution model of achievement motivation and emotion was used as a theoretical foundation to examine the mediating processes between involuntary job loss and employment status. Seventy-nine manufacturing employees were surveyed 1 month prior to permanent displacement, and finding another job was assessed 18 months later. Covariance structure analysis was used to evaluate goodness of fit and to compare the model to alternative measurement and structural representations. Discriminant validity analyses indicated that the causal dimensions underlying the model were not independent. Model predictions were supported in that internal and stable attributions for job loss negatively influenced finding another job through expectations for re-employment. These predictions held up even after controlling for influential unmeasured variables. Practical and theoretical implications are discussed.

Military Compensation in the Armenian Armed Forces: Life Cycle Cost Model for the Armenian Army

DTIC Science & Technology

2013-12-01

military reform . Retrieved November 5, 2013, from http://russiamil.wordpress.com/2011/12/13/new-pay-structure-approved/ IMF. (2013, October). World...military reform has failed in Russia. International Security, 29(2), 121–158. Gorenburg, D. (2011, December 13). New pay structure approved. Russian

Association between Parental Involvement in School and Child Conduct, Social, and Internalizing Problems: Teacher Report

ERIC Educational Resources Information Center

Kirkhaug, Bente; Drugli, May Britt; Klockner, Christian A.; Morch, Willy-Tore

2013-01-01

The present study examined the factor structure of the Teacher Involvement Questionnaire (Involve-T) by means of exploratory factor analysis and examined the association between children's socio-emotional and behavioural problems and teacher-reported parental involvement in school, using structural equation modelling. The study was conducted with…

Numerical Modeling of Inverse Problems under Uncertainty for Damage Detection in Aircraft Structures

DTIC Science & Technology

2013-08-01

et al . (2007): Structural health monitoring with piezoelectric wafer active sensors for space applications, AIAA JOURNAL, V. 45, p. 2838-2850. [4...International Journal of Heat and Mass Transfer, v. 55, p. 2219 -2228. 4. Myers, MR; Jorge, AB; Mutton, MJ; Walker, DG (2012): High heat flux point

Building Habitats on the Moon: Engineering Approaches to Lunar Settlements

NASA Astrophysics Data System (ADS)

Benaroya, H.

This book provides an overview of various concepts for lunar habitats and structural designs and characterizes the lunar environment - the technical and the nontechnical. The designs take into consideration psychological comfort, structural strength against seismic and thermal activity, as well as internal pressurization and 1/6 g. Also discussed are micrometeoroid modelling, risk and redundancy as well as probability and reliability, with an introduction to analytical tools that can be useful in modelling uncertainties.

Internal marketing, customer orientation, and organizational commitment: moderating effects of work status.

PubMed

Huang, Meiju; Chen, Mei-Yen

2013-08-01

Associations among internal marketing, customer orientation, and organizational commitment were examined, particularly with regard to the moderating effects of work status on the relationships between internal marketing and customer orientation or organizational commitment, in a cross-sectional design with structural equation modeling. Two studies (Ns = 119 and 251) were conducted among full- and part-time service employees at Taipei Sports Centers. Internal marketing was associated with organizational commitment and customer orientation. Customer orientation was associated with organizational commitment and partially mediated the relation between internal marketing and organizational commitment. Furthermore, work status significantly moderated the relationships between internal marketing and customer orientation but not between internal marketing and organizational commitment. Implications and directions for future research were discussed.

Internalized Homophobia and Relationship Quality among Lesbians, Gay Men, and Bisexuals.

PubMed

Frost, David M; Meyer, Ilan H

2009-01-01

We examined the associations between internalized homophobia, outness, community connectedness, depressive symptoms, and relationship quality among a diverse community sample of 396 lesbian, gay, and bisexual (LGB) individuals. Structural equation models showed that internalized homophobia was associated with greater relationship problems both generally and among coupled participants independent of outness and community connectedness. Depressive symptoms mediated the association between internalized homophobia and relationship problems. This study improves current understandings of the association between internalized homophobia and relationship quality by distinguishing between the effects of the core construct of internalized homophobia and its correlates and outcomes. The findings are useful for counselors interested in interventions and treatment approaches to help LGB individuals cope with internalized homophobia and relationship problems.

Internalized Homophobia and Relationship Quality among Lesbians, Gay Men, and Bisexuals

PubMed Central

Frost, David M.; Meyer, Ilan H.

2008-01-01

We examined the associations between internalized homophobia, outness, community connectedness, depressive symptoms, and relationship quality among a diverse community sample of 396 lesbian, gay, and bisexual (LGB) individuals. Structural equation models showed that internalized homophobia was associated with greater relationship problems both generally and among coupled participants independent of outness and community connectedness. Depressive symptoms mediated the association between internalized homophobia and relationship problems. This study improves current understandings of the association between internalized homophobia and relationship quality by distinguishing between the effects of the core construct of internalized homophobia and its correlates and outcomes. The findings are useful for counselors interested in interventions and treatment approaches to help LGB individuals cope with internalized homophobia and relationship problems. PMID:20047016

An SEM Assessment of the Internal Structure and Predictive Validity of the Abbreviated Early Adolescent HOME Inventory.

PubMed

Green, Samuel B; Pennar, Amy L; Bradley, Robert H

2018-05-01

The Home Observation for Measurement of the Environment (HOME) Inventory is designed to assess the quality and quantity of support, stimulation, and structure provided to children in the home environment. HOME has been widely used for research and applied purposes. We focused on an abbreviated version of the Early Adolescent HOME (EA-HOME-A) that was administered to 15-year-old adolescents and their parents ( N = 958) as part of the NICHD (National Institute of Child Health and Human Development) Study of Early Child Care and Youth Development. Our study had two objectives. First, we hypothesized and tested a bifactor model that specified a general factor in support of the use of the HOME total score and group factors for subsets of items in support of the content domain scores. Second, we applied structural equation modeling to relate the EA-HOME-A factors to outcome factors assessing maladaptive behaviors, autonomy, self-control, and cognitive-academic performance. The results supported the construct validity of the EA-HOME-A with respect to its internal structure as well as its correlates.

Monitoring on internal temperature of composite insulator with embedding fiber Bragg grating for early diagnosis

NASA Astrophysics Data System (ADS)

Chen, Wen; Tang, Ming

2017-04-01

The abnormal temperature rise is the precursor of the defective composite insulator in power transmission line. However no consolidated techniques or methodologies can on line monitor its internal temperature now. Thus a new method using embedding fiber Bragg grating (FBG) in fiber reinforced polymer (FRP) rod is adopted to monitor its internal temperature. To correctly demodulate the internal temperature of FRP rod from the Bragg wavelength shift of FBG, the conversion coefficient between them is deduced theoretically based on comprehensive investigation on the thermal stresses of the metal-composite joint, as well as its material and structural properties. Theoretical model shows that the conversion coefficients of FBG embedded in different positions will be different because of non-uniform thermal stress distribution, which is verified by an experiment. This work lays the theoretical foundation of monitoring the internal temperature of composite insulator with embedding FBG, which is of great importance to its health structural monitoring, especially early diagnosis.

CEAS/AIAA/ICASE/NASA Langley International Forum on Aeroelasticity and Structural Dynamics 1999. Pt. 1

NASA Technical Reports Server (NTRS)

Woodrow Whitlow, Jr. (Editor); Todd, Emily N. (Editor)

1999-01-01

These proceedings represent a collection of the latest advances in aeroelasticity and structural dynamics from the world community. Research in the areas of unsteady aerodynamics and aeroelasticity, structural modeling and optimization, active control and adaptive structures, landing dynamics, certification and qualification, and validation testing are highlighted in the collection of papers. The wide range of results will lead to advances in the prediction and control of the structural response of aircraft and spacecraft.

The Role of Distal Minority Stress and Internalized Transnegativity in Suicidal Ideation and Nonsuicidal Self-Injury Among Transgender Adults.

PubMed

Staples, Jennifer M; Neilson, Elizabeth C; Bryan, Amanda E B; George, William H

Transgender people are at elevated risk for nonsuicidal self-injury (NSSI) and suicidal ideation compared to the general population. Transgender (trans) refers to a diverse group of people who experience incongruence between their gender identity and sex assigned at birth. The present study is guided by the minority stress model and the psychological mediation framework, which postulate that sexual minority groups experience elevated stress as a result of anti-minority prejudice, contributing to negative mental health outcomes. This study utilized these theories to investigate the role of internalized transnegativity-internalization of negative societal attitudes about one's trans identity-in the relationships of distal trans stress to suicidal ideation and NSSI. A U.S. national sample of trans adults (N = 237) completed a battery of online measures. Structural equation modeling (SEM) was used to compare models with mediation and moderation effects. Results suggested that internalized transnegativity acts as both a mediator and a moderator in the relationship between distal trans stress and suicidal ideation. Log likelihood comparisons suggested moderation models had the superior fit for these data. Results suggest that clinical interventions should directly target individuals' internalized transnegativity as well as societal-level transnegativity.

The relation between attachment, personality, internalizing, and externalizing dimensions in adolescents with borderline personality disorder.

PubMed

Ramos, Vera; Canta, Guilherme; de Castro, Filipa; Leal, Isabel

2016-01-01

The relation between attachment and personality features is an important field to explore in adolescent borderline personality disorder (BPD), and previous research has shown that personality features may be conceptualized within latent internalizing and externalizing dimensions. This cross-sectional study used a structural equation model to examine the association between the BPD participants' perception of attachment and personality features, mediated by the underlying internalizing/externalizing personality dimensions. Data were analyzed for 60 adolescents, ages 15 to 18 years, diagnosed with BPD who completed attachment and personality self-report measures. The authors' results showed a good fit of the model, suggesting a significant association between attachment and the internalizing/externalizing dimensions, which simultaneously congregate and influence personality traits. The perception of attachment anxiety was positively related to the internalizing dimension and at the same time negatively related to the externalizing dimension. However, the perception of attachment avoidance was not related to internalizing or externalizing personality dimensions.

[Dimensions of Empathy in Ex-Combatants of the Colombian Armed Conflict Using a Standardized Scale].

PubMed

Pineda, David A; Aguirre-Acevedo, Daniel Camilo; Trujillo, Natalia; Valencia, Ana María; Pareja, Ángela; Tobón, Carlos; Velilla, Lina; Ibáñez, Agustín

2013-03-01

Empathy is one of the main concepts of in social neurosciences. It is defined as a trait with multiple dimensions allowing individuals to place themselves in the emotional states of others. Colombia has an irregular, internal and long-lasting armed conflict which has been increasing its cruelty levels. to assess the empathy dimensions of 285 ex-combatants from the internal Colombian conflict, using the Interpersonal Reactivity Index(IRI) in Spanish. METHODOLOGY AND SUBJECTS: a sample of 285 male ex-combatants, 241 (84, 6%) males: 85,3% paramilitaries, and 14,7% guerillas. The 28 Item IRI questionnaires were administered. 3 exploratory factor analyses (EFA) were performed. Confirmatory factor analyses (CFA) were developed using structural equation procedures. The first EFA obtained 9 factors (KMO=0,74, variance 54,7% and internal consistency (IC): 0,22 - 0,63). The second EFA produced 20 items with burdens above 0,4 and showed a 6-factor structure (KMO=0,70, variance 50,3%, IC: 0,37 - 0,63). The third EFA forced the 4 original IRI dimensions (KMO=0,74, variance 33,77, IC: 0,44 - 0,77. CFAs showed goodness of adjustment indexes adequate for the three models. The 4-factor model obtained the lowest value, while the 6-factor model obtained the highest. The 4- factor model showed the best IC. The Spanish IRI administered to ex-combatants of the Colombian conflict has possible structures of 4, 6 and 9 factors. The best adjustment was for the 6-fctor. The 4-factor model exhibited the best IC. Copyright © 2013 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

The structure of psychopathology in adolescence and its common personality and cognitive correlates.

PubMed

Castellanos-Ryan, Natalie; Brière, Frederic N; O'Leary-Barrett, Maeve; Banaschewski, Tobias; Bokde, Arun; Bromberg, Uli; Büchel, Christian; Flor, Herta; Frouin, Vincent; Gallinat, Juergen; Garavan, Hugh; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomas; Pausova, Zdenka; Rietschel, Marcella; Smolka, Michael N; Robbins, Trevor W; Whelan, Robert; Schumann, Gunter; Conrod, Patricia

2016-11-01

The traditional view that mental disorders are distinct, categorical disorders has been challenged by evidence that disorders are highly comorbid and exist on a continuum (e.g., Caspi et al., 2014; Tackett et al., 2013). The first objective of this study was to use structural equation modeling to model the structure of psychopathology in an adolescent community-based sample (N = 2,144) including conduct disorder, attention-deficit/hyperactivity disorder (ADHD), oppositional-defiant disorder (ODD), obsessive-compulsive disorder, eating disorders, substance use, anxiety, depression, phobias, and other emotional symptoms, assessed at 16 years. The second objective was to identify common personality and cognitive correlates of psychopathology, assessed at 14 years. Results showed that psychopathology at 16 years fit 2 bifactor models equally well: (a) a bifactor model, reflecting a general psychopathology factor, as well as specific externalizing (representing mainly substance misuse and low ADHD) and internalizing factors; and (b) a bifactor model with a general psychopathology factor and 3 specific externalizing (representing mainly ADHD and ODD), substance use and internalizing factors. The general psychopathology factor was related to high disinhibition/impulsivity, low agreeableness, high neuroticism and hopelessness, high delay-discounting, poor response inhibition and low performance IQ. Substance use was specifically related to high novelty-seeking, sensation-seeking, extraversion, high verbal IQ, and risk-taking. Internalizing psychopathology was specifically related to high neuroticism, hopelessness and anxiety-sensitivity, low novelty-seeking and extraversion, and an attentional bias toward negatively valenced verbal stimuli. Findings reveal several nonspecific or transdiagnostic personality and cognitive factors that may be targeted in new interventions to potentially prevent the development of multiple psychopathologies. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The Structure of Psychopathology in Adolescence and Its Common Personality and Cognitive Correlates

PubMed Central

2016-01-01

The traditional view that mental disorders are distinct, categorical disorders has been challenged by evidence that disorders are highly comorbid and exist on a continuum (e.g., Caspi et al., 2014; Tackett et al., 2013). The first objective of this study was to use structural equation modeling to model the structure of psychopathology in an adolescent community-based sample (N = 2,144) including conduct disorder, attention-deficit/hyperactivity disorder (ADHD), oppositional-defiant disorder (ODD), obsessive–compulsive disorder, eating disorders, substance use, anxiety, depression, phobias, and other emotional symptoms, assessed at 16 years. The second objective was to identify common personality and cognitive correlates of psychopathology, assessed at 14 years. Results showed that psychopathology at 16 years fit 2 bifactor models equally well: (a) a bifactor model, reflecting a general psychopathology factor, as well as specific externalizing (representing mainly substance misuse and low ADHD) and internalizing factors; and (b) a bifactor model with a general psychopathology factor and 3 specific externalizing (representing mainly ADHD and ODD), substance use and internalizing factors. The general psychopathology factor was related to high disinhibition/impulsivity, low agreeableness, high neuroticism and hopelessness, high delay-discounting, poor response inhibition and low performance IQ. Substance use was specifically related to high novelty-seeking, sensation-seeking, extraversion, high verbal IQ, and risk-taking. Internalizing psychopathology was specifically related to high neuroticism, hopelessness and anxiety-sensitivity, low novelty-seeking and extraversion, and an attentional bias toward negatively valenced verbal stimuli. Findings reveal several nonspecific or transdiagnostic personality and cognitive factors that may be targeted in new interventions to potentially prevent the development of multiple psychopathologies. PMID:27819466

Internal protein motions in molecular-dynamics simulations of Bragg and diffuse X-ray scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wall, Michael E.

Molecular-dynamics (MD) simulations of Bragg and diffuse X-ray scattering provide a means of obtaining experimentally validated models of protein conformational ensembles. This paper shows that compared with a single periodic unit-cell model, the accuracy of simulating diffuse scattering is increased when the crystal is modeled as a periodic supercell consisting of a 2 × 2 × 2 layout of eight unit cells. The MD simulations capture the general dependence of correlations on the separation of atoms. There is substantial agreement between the simulated Bragg reflections and the crystal structure; there are local deviations, however, indicating both the limitation of using a single structuremore » to model disordered regions of the protein and local deviations of the average structure away from the crystal structure. Although it was anticipated that a simulation of longer duration might be required to achieve maximal agreement of the diffuse scattering calculation with the data using the supercell model, only a microsecond is required, the same as for the unit cell. Rigid protein motions only account for a minority fraction of the variation in atom positions from the simulation. The results indicate that protein crystal dynamics may be dominated by internal motions rather than packing interactions, and that MD simulations can be combined with Bragg and diffuse X-ray scattering to model the protein conformational ensemble.« less

Internal protein motions in molecular-dynamics simulations of Bragg and diffuse X-ray scattering

DOE PAGES

Wall, Michael E.

2018-01-25

Molecular-dynamics (MD) simulations of Bragg and diffuse X-ray scattering provide a means of obtaining experimentally validated models of protein conformational ensembles. This paper shows that compared with a single periodic unit-cell model, the accuracy of simulating diffuse scattering is increased when the crystal is modeled as a periodic supercell consisting of a 2 × 2 × 2 layout of eight unit cells. The MD simulations capture the general dependence of correlations on the separation of atoms. There is substantial agreement between the simulated Bragg reflections and the crystal structure; there are local deviations, however, indicating both the limitation of using a single structuremore » to model disordered regions of the protein and local deviations of the average structure away from the crystal structure. Although it was anticipated that a simulation of longer duration might be required to achieve maximal agreement of the diffuse scattering calculation with the data using the supercell model, only a microsecond is required, the same as for the unit cell. Rigid protein motions only account for a minority fraction of the variation in atom positions from the simulation. The results indicate that protein crystal dynamics may be dominated by internal motions rather than packing interactions, and that MD simulations can be combined with Bragg and diffuse X-ray scattering to model the protein conformational ensemble.« less

Changing culture in the home health setting: strategies for success.

PubMed

Boan, David

2006-01-01

Organizational culture is generally defined as the internal attributes of the staff, such as their values, beliefs, and attitudes. Although technically accurate as a definition, personal attributes defy direct intervention, leading some to question whether it is possible to change culture. It is proposed that it is possible to change the personal internal attributes that define organizational culture by changing the characteristic structures and behaviors of the organization that shape those attributes. This model, called the Quality Capability Model, creates an approach to culture change that accommodates the unique features of home health.

Results from Radio Tracking the Rosetta Spacecraft: Gravity, Internal Structure and Nucleus Composition of 67P/Churyumov-Gerasimenko

NASA Astrophysics Data System (ADS)

Hahn, M.; Andert, T.; Asmar, S.; Bird, M. K.; Häusler, B.; Peter, K.; Tellmann, S.; Weissman, P. R.; Barriot, J. P.; Sierks, H.

2017-12-01

When Rosetta arrived at its target comet 67P/Churyumov-Gerasimenko it first performed a series of distant flybys (100 - 30 km). During this mission phase the mass of the comets nucleus could be determined by analyzing the RSI radio tracking data. In combination with the volume from images of the OSIRIS camera this resulted in a precise bulk density determination. That already gave first insights into the comets interior structure. The nucleus appears to be a low-density, highly porous dusty body. From bound orbits with distances below 30 km the low degree and order gravity field coefficients could be derived. The gravity field coefficients strongly depend on the nucleus irregular shape and on the interior mass distribution. The shape is very well reconstructed from of the OSIRIS camera images. Various models of the interior nucleus structure and density distributions are used to compute simulated values of the gravity field coefficients. A comparison with the observed coefficients yields the feasibility of the theoretical interior structure. Thus, the gravity field helps constraining models of the internal structure, the composition and also of the origin and formation of the comets nucleus.

Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation.

PubMed

Barton, Hugh A; Chiu, Weihsueh A; Setzer, R Woodrow; Andersen, Melvin E; Bailer, A John; Bois, Frédéric Y; Dewoskin, Robert S; Hays, Sean; Johanson, Gunnar; Jones, Nancy; Loizou, George; Macphail, Robert C; Portier, Christopher J; Spendiff, Martin; Tan, Yu-Mei

2007-10-01

Physiologically based pharmacokinetic (PBPK) models are used in mode-of-action based risk and safety assessments to estimate internal dosimetry in animals and humans. When used in risk assessment, these models can provide a basis for extrapolating between species, doses, and exposure routes or for justifying nondefault values for uncertainty factors. Characterization of uncertainty and variability is increasingly recognized as important for risk assessment; this represents a continuing challenge for both PBPK modelers and users. Current practices show significant progress in specifying deterministic biological models and nondeterministic (often statistical) models, estimating parameters using diverse data sets from multiple sources, using them to make predictions, and characterizing uncertainty and variability of model parameters and predictions. The International Workshop on Uncertainty and Variability in PBPK Models, held 31 Oct-2 Nov 2006, identified the state-of-the-science, needed changes in practice and implementation, and research priorities. For the short term, these include (1) multidisciplinary teams to integrate deterministic and nondeterministic/statistical models; (2) broader use of sensitivity analyses, including for structural and global (rather than local) parameter changes; and (3) enhanced transparency and reproducibility through improved documentation of model structure(s), parameter values, sensitivity and other analyses, and supporting, discrepant, or excluded data. Longer-term needs include (1) theoretical and practical methodological improvements for nondeterministic/statistical modeling; (2) better methods for evaluating alternative model structures; (3) peer-reviewed databases of parameters and covariates, and their distributions; (4) expanded coverage of PBPK models across chemicals with different properties; and (5) training and reference materials, such as cases studies, bibliographies/glossaries, model repositories, and enhanced software. The multidisciplinary dialogue initiated by this Workshop will foster the collaboration, research, data collection, and training necessary to make characterizing uncertainty and variability a standard practice in PBPK modeling and risk assessment.

Elastic properties of graphene: A pseudo-beam model with modified internal bending moment and its application

NASA Astrophysics Data System (ADS)

Xia, Z. M.; Wang, C. G.; Tan, H. F.

2018-04-01

A pseudo-beam model with modified internal bending moment is presented to predict elastic properties of graphene, including the Young's modulus and Poisson's ratio. In order to overcome a drawback in existing molecular structural mechanics models, which only account for pure bending (constant bending moment), the presented model accounts for linear bending moments deduced from the balance equations. Based on this pseudo-beam model, an analytical prediction is accomplished to predict the Young's modulus and Poisson's ratio of graphene based on the equation of the strain energies by using Castigliano second theorem. Then, the elastic properties of graphene are calculated compared with results available in literature, which verifies the feasibility of the pseudo-beam model. Finally, the pseudo-beam model is utilized to study the twisting wrinkling characteristics of annular graphene. Due to modifications of the internal bending moment, the wrinkling behaviors of graphene sheet are predicted accurately. The obtained results show that the pseudo-beam model has a good ability to predict the elastic properties of graphene accurately, especially the out-of-plane deformation behavior.

Gravity Survey at the Ceboruco Volcano Area (Nayarit, Mexico): a 3-D Model of the Subsurface Structure

NASA Astrophysics Data System (ADS)

Fernandez-Cordoba, Jhonattan; Zamora-Camacho, Araceli; Espindola, Juan Manuel

2017-10-01

Ceboruco volcano (-104°30', 21°7', 2150 m asl) is located in the western portion of the trans-Mexican volcanic belt and NW extreme of the Tepic-Zacoalco rift zone, a structure composed of a series of NNW-trending en echelon fault-bounded basins constituting the NE boundary between the north-American plate and the Jalisco block (JB). Ceboruco experimented a Plinian eruption about 1000 years ago and several more of different styles afterward; the last one in 1870 CE. This volcano poses a significant risk because of the relatively large population in its surroundings. Ceboruco has been studied by mostly from the point of view of petrology, geochemistry, and physical volcanology; however, no geophysical studies about its internal structure have been published. In this paper, we present the results of a gravimetric survey carried out in its surroundings and a model of the internal structure obtained from inversion of the data. The Ceboruco area is characterized by a negative Bouguer anomaly spanning the volcanic structure. The probable causative body modeled with the data of the survey is located about 1 km below mean sea level and has a volume of 163 km3. We propose that this body is the magma chamber from where the products of its eruptions in the last 1000 years ensued.

Probing the internal structure of the asteriod Didymoon with a passive seismic investigation

NASA Astrophysics Data System (ADS)

Murdoch, N.; Hempel, S.; Pou, L.; Cadu, A.; Garcia, R. F.; Mimoun, D.; Margerin, L.; Karatekin, O.

2017-09-01

Understanding the internal structure of an asteroid has important implications for interpreting its evolutionary history, for understanding its continuing geological evolution, and also for asteroid deflection and in-situ space resource utilisation. Given the strong evidence that asteroids are seismically active, an in-situ passive seismic experiment could provide information about the asteroid surface and interior properties. Here, we discuss the natural seismic activity that may be present on Didymoon, the secondary component of asteroid (65803) Didymos. Our analysis of the tidal stresses in Didymoon shows that tidal quakes are likely to occur if the secondary has an eccentric orbit. Failure occurs most easily at the asteroid poles and close to the surface for both homogeneous and layered internal structures. Simulations of seismic wave propagation in Didymoon show that the seismic moment of even small meteoroid impacts can generate clearly observable body and surface waves if the asteroid's internal structure is homogeneous. The presence of a regolith layer over a consolidated core can result in the seismic energy becoming trapped in the regolith due to the strong impedance contrast at the regolith-core boundary. The inclusion of macro-porosity (voids) further complexifies the wavefield due to increased scattering. The most prominent seismic waves are always found to be those traveling along the surface of the asteroid and those focusing in the antipodal point of the seismic source. We find also that the waveforms and ground acceleration spectra allow discrimination between the different internal structure models. Although the science return of a passive seismic experiment would be enhanced by having multiple seismic stations, one single seismic station can already vastly improve our knowledge about the seismic environment and sub-surface structure of an asteroid. We describe several seismic measurement techniques that could be applied in order to study the asteroid internal structure with one three-component seismic station.

Student Satisfaction With an Innovative Internship

PubMed Central

Petrila, Ann; Fireman, Orah; Fitzpatrick, Leslie Schnoll; Hodas, Robyn Wertheimer; Taussig, Heather N.

2014-01-01

This article describes an internship program designed specifically to meet graduate students’ training needs within the context of their work in a prevention program for children in foster care. An internship based on a strong model of intern recruitment and supervision, structured inclusion of interns in a supportive agency culture, a manualized orientation, and an ongoing didactic program, was hypothesized to result in a positive experience for interns. Results of anonymous surveys administered to 102 interns over a 9-year period assessing their internship experience are presented and discussed. Recommendations are made for development of internship training sites. PMID:25642119

Attachment Working Models as Unconscious Structures: An Experimental Test

ERIC Educational Resources Information Center

Maier, Markus A.; Bernier, Annie; Pekrun, Reinhard; Zimmermann, Peter; Grossmann, Klaus E.

2004-01-01

Internal working models of attachment (IWMs) are presumed to be largely "unconscious" representations of childhood attachment experiences. Several instruments have been developed to assess IWMs; some of them are based on self-report and others on narrative interview techniques. This study investigated the capacity of a self-report measure, the…

Socioeconomic Status and Internalizing Symptoms in Chilean Children: Does Reserve Capacity Matter?

PubMed Central

Martinez, Suzanna M; Castillo, Marcela; Lozoff, Betsy; Gahagan, Sheila

2016-01-01

Informed by the reserve capacity model, we examined pathways between socioeconomic status (SES) and internalizing symptoms (IS) in 1119 Chilean 10-year-olds. Mediators included parental disciplinary style and reserve capacity resources (RCR), namely home environment, parent-child engagement, and self-esteem, and conduct problems. Using structural equation modeling, the model was stratified by gender. For boys, the SES-IS relationship was mediated by the home environment and parental disciplinary style. For girls, the SES-IS relationship was mediated by the home environment, parent-child engagement, self-esteem, and conduct problems. Findings suggest different RCR may protect against IS in a sample of Chilean children. PMID:27123471

Contribution of SELENE-2 geodetic measurements to constrain the lunar internal structure

NASA Astrophysics Data System (ADS)

Matsumoto, K.; Kikuchi, F.; Yamada, R.; Iwata, T.; Kono, Y.; Tsuruta, S.; Hanada, H.; Goossens, S. J.; Ishihara, Y.; Kamata, S.; Sasaki, S.

2012-12-01

Internal structure and composition of the Moon provide important clue and constraints on theories for how the Moon formed and evolved. The Apollo seismic network has contributed to the internal structure modeling. Efforts have been made to detect the lunar core from the noisy Apollo data (e.g., [1], [2]), but there is scant information about the structure below the deepest moonquakes at about 1000 km depth. On the other hand, there have been geodetic studies to infer the deep structure of the Moon. For example, LLR (Lunar Laser Ranging) data analyses detected a displacement of the lunar pole of rotation, indicating that dissipation is acting on the rotation arising from a fluid core [3]. Bayesian inversion using geodetic data (such as mass, moments of inertia, tidal Love numbers k2 and h2, and quality factor Q) also suggests a fluid core and partial melt in the lower mantle region [4]. Further improvements in determining the second-degree gravity coefficients (which will lead to better estimates of moments of inertia) and the Love number k2 will help us to better constrain the lunar internal structure. Differential VLBI (Very Long Baseline Interferometry) technique, which was used in the Japanese lunar exploration mission SELENE (Sept. 2007 - June 2009), is expected to contribute to better determining the second-degree potential Love number k2 and low-degree gravity coefficients. SELENE will be followed by the future lunar mission SELENE-2 which will carry both a lander and an orbiter. We propose to put the SELENE-type radio sources on these spacecraft in order to accurately estimate k2 and the low-degree gravity coefficients. By using the same-beam VLBI tracking technique, these parameters will be retrieved through precision orbit determination of the orbiter with respect to the lander which serves as a reference. The VLBI mission with the radio sources is currently one of the mission candidates for SELENE-2. We have conducted a preliminary simulation study on the anticipated k2 accuracy. With the assumed mission duration of about 3 months and the arc length of 14 days, the k2 accuracy is estimated to be better than 1 %, where the uncertainty is evaluated as 10 times the formal error considering the errors in the non-conservative force modeling and in the lander position. We carried out a feasibility study using Bayesian inversion on how well we can constrain the lunar internal structure by the geodetic data to be improved by SELENE-2. It will be shown that such improved geodetic data contribute to narrow the range of the plausible internal structure models, but there are still trade-offs among crust, mantle, and core structures. Preliminary simulation results will be presented to show that the accuracy of core structure estimation will be improved in consequence of better determination of the mantle structure by combining the geodetic data with the seismic data. References [1] Weber et al. (2011), Science, 331, 309-312, doi:10.1126/science.1199375 [2] Garcia eta l. (2011), PEPI, doi:10.1016/j.pepi.2011.06.015 [3] Williams et al. (2001), JGR, 106, E11, 27,933-27,968 [4] Khan and Mosegaard (2005), GRL, 32, L22203, doi:10.1029/2005GL023985

Modeling the Effects of Transbasin Nonlinear Internal Waves Through the South China Sea Basin

DTIC Science & Technology

2013-06-01

sound propagation through the SCS needs to be developed to help maintain tactical superiority. This model will provide valuable information for...METHODOLOGY A. ACOUSTIC MODEL 1. Ray Trace Theory Modeling of sound propagation through the ocean requires solving the governing spherical wave equation...arrival structure simulation code. The model permits the study of the physics and phenomenology of sound propagation though the SCS

Internal structure of the Moon inferred from Apollo seismic data and selenodetic data from GRAIL and LLR

NASA Astrophysics Data System (ADS)

Matsumoto, Koji; Yamada, Ryuhei; Kikuchi, Fuyuhiko; Kamata, Shunichi; Ishihara, Yoshiaki; Iwata, Takahiro; Hanada, Hideo; Sasaki, Sho

2015-09-01

The internal structure of the Moon is important for discussions on its origin and evolution. However, the deep structure of the Moon is still debated due to the absence of comprehensive seismic data. This study explores lunar interior models by complementing Apollo seismic travel time data with selenodetic data which have recently been improved by Gravity Recovery and Interior Laboratory (GRAIL) and Lunar Laser Ranging (LLR). The observed data can be explained by models including a deep-seated zone with a low velocity (S wave velocity = 2.9 ± 0.5 km/s) and a low viscosity (˜3 × 1016 Pa s). The thickness of this zone above the core-mantle boundary is larger than 170 km, showing a negative correlation with the radius of the fluid outer core. The inferred density of the lowermost mantle suggests a high TiO2 content (>11 wt.%) which prefers a mantle overturn scenario.

Hirarchical emotion calculation model for virtual human modellin - biomed 2010.

PubMed

Zhao, Yue; Wright, David

2010-01-01

This paper introduces a new emotion generation method for virtual human modelling. The method includes a novel hierarchical emotion structure, a group of emotion calculation equations and a simple heuristics decision making mechanism, which enables virtual humans to perform emotionally in real-time according to their internal and external factors. Emotion calculation equations used in this research were derived from psychologic emotion measurements. Virtual humans can utilise the information in virtual memory and emotion calculation equations to generate their own numerical emotion states within the hierarchical emotion structure. Those emotion states are important internal references for virtual humans to adopt appropriate behaviours and also key cues for their decision making. A simple heuristics theory is introduced and integrated into decision making process in order to make the virtual humans decision making more like a real human. A data interface which connects the emotion calculation and the decision making structure together has also been designed and simulated to test the method in Virtools environment.

High Energy Wide Area Blunt Impact on Composite Aircraft Structures

NASA Astrophysics Data System (ADS)

DeFrancisci, Gabriela K.

The largest source of damage to commercial aircraft is caused by accidental contact with ground service equipment (GSE). The cylindrical bumper typically found on GSE distributes the impact load over a large contact area, possibly spanning multiple internal structural elements (frame bays) of a stiffened-skin fuselage. This type of impact can lead to damage that is widespread and difficult to detect visually. To address this problem, monolithic composite panels of various size and complexity have been modeled and tested quasi-statically and dynamically. The experimental observations have established that detectability is dependent on the impact location and immediately-adjacent internal structure of the panel, as well as the impactor geometry and total deformation of the panel. A methodology to model and predict damage caused by wide area blunt impact events was established, which was then applied to more general cases that were not tested in order to better understand the nature of this type of impact event and how it relates to the final damage state and visual detectability.

Energy-density field approach for low- and medium-frequency vibroacoustic analysis of complex structures using a statistical computational model

NASA Astrophysics Data System (ADS)

Kassem, M.; Soize, C.; Gagliardini, L.

2009-06-01

In this paper, an energy-density field approach applied to the vibroacoustic analysis of complex industrial structures in the low- and medium-frequency ranges is presented. This approach uses a statistical computational model. The analyzed system consists of an automotive vehicle structure coupled with its internal acoustic cavity. The objective of this paper is to make use of the statistical properties of the frequency response functions of the vibroacoustic system observed from previous experimental and numerical work. The frequency response functions are expressed in terms of a dimensionless matrix which is estimated using the proposed energy approach. Using this dimensionless matrix, a simplified vibroacoustic model is proposed.

Fairbairn's Theory of Change.

PubMed

Celani, David P

2016-06-01

Fairbairn's unique structural theory with its three pairs of selves and objects has proven to be a highly usable and practical model of the human psyche, yet it has remained a minor player in the world of psychoanalysis. There are a number of factors that account for its lack of popularity, foremost among them the timing of the model's introduction to the analytic community. Fairbairn's four successive papers that described his metapsychology (1940, 1941, 1943, and 1944) were published just after Freud's death, when his theory was the dominant model of psychoanalysis. Additionally, Fairbairn's model was incomplete, used unfamiliar terminology, and, in its singularity, forced the analyst to abandon drive theory, the heart of Freud's metapsychology. This paper will examine and update Fairbairn's unique model of change-from the outset of pathology that begins with attachment to bad objects, to their metamorphosis into internal structures and finally to techniques of treatment that reduce their influence on the patients' internal world. The treatment section carefully follows Fairbairn's metapsychology, and focuses first on the analyst becoming a good object in the eyes of the patient, then unearthing bad object memories in a safe and compassionate interpersonal environment, engaging the patient's substructures in a manner that does not intensify preexisting internal templates, and finally aiding the patient in resuming his or her stalled emotional development. This exegesis of Fairbairn original model, along with recent modifications that have been made to it, demonstrates the consistency, clear focus, and utility of this little-known metapsychology.

Frame of Reference Model of Self-Concept and Locus of Control: A Cross Gender Study in the United Arab Emirates.

ERIC Educational Resources Information Center

Abu-Hilal, Maher M.

A study tested predictions for I/E (internal external) frame of reference model and extended this model to include locus of control. A sample of upper elementary (n=181) and junior high (n=191) students in the United Arab Emirates participated in the study. Structural equation modeling (SEM) analyses provided support to the external comparison…

Facilitating the openEHR approach - organizational structures for defining high-quality archetypes.

PubMed

Kohl, Christian Dominik; Garde, Sebastian; Knaup, Petra

2008-01-01

Using openEHR archetypes to establish an electronic patient record promises rapid development and system interoperability by using or adopting existing archetypes. However, internationally accepted, high quality archetypes which enable a comprehensive semantic interoperability require adequate development and maintenance processes. Therefore, structures have to be created involving different health professions. In the following we present a model which facilitates and governs distributed but cooperative development and adoption of archetypes by different professionals including peer reviews. Our model consists of a hierarchical structure of professional committees and descriptions of the archetype development process considering these different committees.

CHEMICAL STRUCTURE INDEXING OF TOXICITY DATA ON ...

EPA Pesticide Factsheets

Standardized chemical structure annotation of public toxicity databases and information resources is playing an increasingly important role in the 'flattening' and integration of diverse sets of biological activity data on the Internet. This review discusses public initiatives that are accelerating the pace of this transformation, with particular reference to toxicology-related chemical information. Chemical content annotators, structure locator services, large structure/data aggregator web sites, structure browsers, International Union of Pure and Applied Chemistry (IUPAC) International Chemical Identifier (InChI) codes, toxicity data models and public chemical/biological activity profiling initiatives are all playing a role in overcoming barriers to the integration of toxicity data, and are bringing researchers closer to the reality of a mineable chemical Semantic Web. An example of this integration of data is provided by the collaboration among researchers involved with the Distributed Structure-Searchable Toxicity (DSSTox) project, the Carcinogenic Potency Project, projects at the National Cancer Institute and the PubChem database. Standardizing chemical structure annotation of public toxicity databases

Topology optimization analysis based on the direct coupling of the boundary element method and the level set method

NASA Astrophysics Data System (ADS)

Vitório, Paulo Cezar; Leonel, Edson Denner

2017-12-01

The structural design must ensure suitable working conditions by attending for safe and economic criteria. However, the optimal solution is not easily available, because these conditions depend on the bodies' dimensions, materials strength and structural system configuration. In this regard, topology optimization aims for achieving the optimal structural geometry, i.e. the shape that leads to the minimum requirement of material, respecting constraints related to the stress state at each material point. The present study applies an evolutionary approach for determining the optimal geometry of 2D structures using the coupling of the boundary element method (BEM) and the level set method (LSM). The proposed algorithm consists of mechanical modelling, topology optimization approach and structural reconstruction. The mechanical model is composed of singular and hyper-singular BEM algebraic equations. The topology optimization is performed through the LSM. Internal and external geometries are evolved by the LS function evaluated at its zero level. The reconstruction process concerns the remeshing. Because the structural boundary moves at each iteration, the body's geometry change and, consequently, a new mesh has to be defined. The proposed algorithm, which is based on the direct coupling of such approaches, introduces internal cavities automatically during the optimization process, according to the intensity of Von Mises stress. The developed optimization model was applied in two benchmarks available in the literature. Good agreement was observed among the results, which demonstrates its efficiency and accuracy.

New paradigms in internal architecture design and freeform fabrication of tissue engineering porous scaffolds.

PubMed

Yoo, Dongjin

2012-07-01

Advanced additive manufacture (AM) techniques are now being developed to fabricate scaffolds with controlled internal pore architectures in the field of tissue engineering. In general, these techniques use a hybrid method which combines computer-aided design (CAD) with computer-aided manufacturing (CAM) tools to design and fabricate complicated three-dimensional (3D) scaffold models. The mathematical descriptions of micro-architectures along with the macro-structures of the 3D scaffold models are limited by current CAD technologies as well as by the difficulty of transferring the designed digital models to standard formats for fabrication. To overcome these difficulties, we have developed an efficient internal pore architecture design system based on triply periodic minimal surface (TPMS) unit cell libraries and associated computational methods to assemble TPMS unit cells into an entire scaffold model. In addition, we have developed a process planning technique based on TPMS internal architecture pattern of unit cells to generate tool paths for freeform fabrication of tissue engineering porous scaffolds. Copyright © 2012 IPEM. Published by Elsevier Ltd. All rights reserved.

Modeling of Microstructure Evolution During the Thermomechanical Processing of Titanium Alloys (Preprint)

DTIC Science & Technology

2008-07-01

Tailoring the Properties of Aluminum and Titanium Alloys", Deformation, Processing, and Structure , G. Krauss, ed., ASM International, Materials Park, OH...1984, pp. 279-354. 51. G.W. Kuhlman, "A Critical Appraisal of Thermomechanical Processing of Structural Titanium Alloys", Microstructure/ Property ... titanium alloys is heavily dependent on the allotropic transformation from a hexagonal-close-packed crystal structure (denoted as alpha phase) found at

Structural mapping from MSS-LANDSAT imagery: A proposed methodology for international geological correlation studies

NASA Technical Reports Server (NTRS)

Dejesusparada, N. (Principal Investigator); Crepani, E.; Martini, P. R.

1980-01-01

A methodology is proposed for international geological correlation studies based on LANDSAT-MSS imagery, Bullard's model of continental fit and compatible structural trends between Northeast Brazil and the West African counterpart. Six extensive lineaments in the Brazilian study area are mapped and discussed according to their regional behavior and in relation to the adjacent continental margin. Among the first conclusions, correlations were found between the Sobral Pedro II Lineament and the megafaults that surround the West African craton; and the Pernambuco Lineament with the Ngaurandere Linemanet in Cameroon. Ongoing research to complete the methodological stages includes the mapping of the West African structural framework, reconstruction of the pre-drift puzzle, and an analysis of the counterpart correlations.

The polygonal model: A simple representation of biomolecules as a tool for teaching metabolism.

PubMed

Bonafe, Carlos Francisco Sampaio; Bispo, Jose Ailton Conceição; de Jesus, Marcelo Bispo

2018-01-01

Metabolism involves numerous reactions and organic compounds that the student must master to understand adequately the processes involved. Part of biochemical learning should include some knowledge of the structure of biomolecules, although the acquisition of such knowledge can be time-consuming and may require significant effort from the student. In this report, we describe the "polygonal model" as a new means of graphically representing biomolecules. This model is based on the use of geometric figures such as open triangles, squares, and circles to represent hydroxyl, carbonyl, and carboxyl groups, respectively. The usefulness of the polygonal model was assessed by undergraduate students in a classroom activity that consisted of "transforming" molecules from Fischer models to polygonal models and vice and versa. The survey was applied to 135 undergraduate Biology and Nursing students. Students found the model easy to use and we noted that it allowed identification of students' misconceptions in basic concepts of organic chemistry, such as in stereochemistry and organic groups that could then be corrected. The students considered the polygonal model easier and faster for representing molecules than Fischer representations, without loss of information. These findings indicate that the polygonal model can facilitate the teaching of metabolism when the structures of biomolecules are discussed. Overall, the polygonal model promoted contact with chemical structures, e.g. through drawing activities, and encouraged student-student dialog, thereby facilitating biochemical learning. © 2017 by The International Union of Biochemistry and Molecular Biology, 46(1):66-75, 2018. © 2017 The International Union of Biochemistry and Molecular Biology.

A GDP-driven model for the binary and weighted structure of the International Trade Network

NASA Astrophysics Data System (ADS)

Almog, Assaf; Squartini, Tiziano; Garlaschelli, Diego

2015-01-01

Recent events such as the global financial crisis have renewed the interest in the topic of economic networks. One of the main channels of shock propagation among countries is the International Trade Network (ITN). Two important models for the ITN structure, the classical gravity model of trade (more popular among economists) and the fitness model (more popular among networks scientists), are both limited to the characterization of only one representation of the ITN. The gravity model satisfactorily predicts the volume of trade between connected countries, but cannot reproduce the missing links (i.e. the topology). On the other hand, the fitness model can successfully replicate the topology of the ITN, but cannot predict the volumes. This paper tries to make an important step forward in the unification of those two frameworks, by proposing a new gross domestic product (GDP) driven model which can simultaneously reproduce the binary and the weighted properties of the ITN. Specifically, we adopt a maximum-entropy approach where both the degree and the strength of each node are preserved. We then identify strong nonlinear relationships between the GDP and the parameters of the model. This ultimately results in a weighted generalization of the fitness model of trade, where the GDP plays the role of a ‘macroeconomic fitness’ shaping the binary and the weighted structure of the ITN simultaneously. Our model mathematically explains an important asymmetry in the role of binary and weighted network properties, namely the fact that binary properties can be inferred without the knowledge of weighted ones, while the opposite is not true.

Using Target Network Modelling to Increase Battlespace Agility

DTIC Science & Technology

2013-06-01

Moffat, James. (2003) Complexity Theory and Network Centric Warfare. Washington DC: CCRP Moore, David T.. Sensemaking : A Structure for an Intelligence...Ted Hopf’s “Promise of Constructivism in International Relations Theory ” presented in International Security in 1998; and Adler 1998. 5 Look to...of warfighting within a doctrinal framework. Based on 10 years of research12 informed by social theory , experimentation, NATO doctrinal studies and

Shame, Internalized Heterosexism, Lesbian Identity, and Coming out to Others: A Comparative Study of Lesbians in Mainland China and Hong Kong

ERIC Educational Resources Information Center

Chow, Pizza Ka-Yee; Cheng, Sheung-Tak

2010-01-01

The purpose of this study was to investigate coming out to family and friends and their relationships to shame, internalized heterosexism, lesbian identity, and perceived social support in Chinese lesbians from 2 different cultural settings--Mainland China (N = 244) and Hong Kong (N = 234). Results of structural equation modeling showed that, in…

SMART Structures User's Guide - Version 3.0

NASA Technical Reports Server (NTRS)

Spangler, Jan L.

1996-01-01

Version 3.0 of the Solid Modeling Aerospace Research Tool (SMART Structures) is used to generate structural models for conceptual and preliminary-level aerospace designs. Features include the generation of structural elements for wings and fuselages, the integration of wing and fuselage structural assemblies, and the integration of fuselage and tail structural assemblies. The highly interactive nature of this software allows the structural engineer to move quickly from a geometry that defines a vehicle's external shape to one that has both external components and internal components which may include ribs, spars, longerons, variable depth ringframes, a floor, a keel, and fuel tanks. The geometry that is output is consistent with FEA requirements and includes integrated wing and empennage carry-through and frame attachments. This report provides a comprehensive description of SMART Structures and how to use it.

Does competence mediate the associations between puberty and internalizing or externalizing problems in adolescent girls?

PubMed

Negriff, Sonya; Hillman, Jennifer B; Dorn, Lorah D

2011-10-01

To examine separate mediational models linking (a) menarcheal status or (b) pubertal timing to internalizing and externalizing problems through competence. This study involved cross-sectional analyses of 262 adolescent girls (age: 11-17 years; mean = 14.93, standard deviation = 2.17) enrolled in a longitudinal study examining the association of psychological functioning and smoking with reproductive and bone health. Measures of menarcheal status (pre/post), pubertal timing (early, on-time, or late), internalizing and externalizing behavior, and perceived competence (parent and adolescent report) were obtained. Structural equation modeling was used for analyses. Perceived competence was found to fully mediate the association between menarcheal status and parent report of internalizing and externalizing problems. For adolescent report, there was a full mediation effect for internalizing problems but a partial mediation effect for externalizing problems. Being menarcheal was related to lower competence, which was in turn related to higher internalizing and externalizing problems. Models including pubertal timing were not significant. Perceived competence is important in understanding the associations between menarcheal status and internalizing and externalizing problems. Interventions targeting competence, particularly in postmenarcheal girls, may reduce or prevent problem behaviors. Copyright © 2011 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

A novel approach to internal crown characterization for coniferous tree species classification

NASA Astrophysics Data System (ADS)

Harikumar, A.; Bovolo, F.; Bruzzone, L.

2016-10-01

The knowledge about individual trees in forest is highly beneficial in forest management. High density small foot- print multi-return airborne Light Detection and Ranging (LiDAR) data can provide a very accurate information about the structural properties of individual trees in forests. Every tree species has a unique set of crown structural characteristics that can be used for tree species classification. In this paper, we use both the internal and external crown structural information of a conifer tree crown, derived from a high density small foot-print multi-return LiDAR data acquisition for species classification. Considering the fact that branches are the major building blocks of a conifer tree crown, we obtain the internal crown structural information using a branch level analysis. The structure of each conifer branch is represented using clusters in the LiDAR point cloud. We propose the joint use of the k-means clustering and geometric shape fitting, on the LiDAR data projected onto a novel 3-dimensional space, to identify branch clusters. After mapping the identified clusters back to the original space, six internal geometric features are estimated using a branch-level analysis. The external crown characteristics are modeled by using six least correlated features based on cone fitting and convex hull. Species classification is performed using a sparse Support Vector Machines (sparse SVM) classifier.

Spatio-temporal variability of internal waves in the northern Gulf of Mexico studied with the Navy Coastal Ocean Model, NCOM

NASA Astrophysics Data System (ADS)

Cambazoglu, M. K.; Jacobs, G. A.; Howden, S. D.; Book, J. W.; Arnone, R.; Soto Ramos, I. M.; Vandermeulen, R. A.; Greer, A. T.; Miles, T. N.

2016-02-01

Internal waves enhance mixing in the upper ocean, transport nutrients and plankton over the water column and across the shelf from deeper waters to shallower coastal areas, and could also transport pollutants such as hydrocarbons onshore during an oil spill event. This study aims to characterize internal waves in the northern Gulf of Mexico (nGoM) and investigate the possible generation and dissipation mechanisms using a high-resolution (1-km) application of the Navy Coastal Ocean Model (NCOM). Three dimensional model products are used to detect the propagation patterns of internal waves. The vertical structure of internal waves is studied and the role of stratification is analyzed by looking at the temperature, salinity and velocity variations along the water column. The model predictions suggest the generation of internal waves on the continental shelf, therefore the role of ocean bottom topography interacting with tides and general circulation features such as the Loop Current Eddy front, on the internal wave generation will be discussed. The time periods of internal wave occurrences are identified from model predictions and compared to satellite ocean color imagery. Further data analysis, e.g. Fourier analysis, is implemented to determine internal wavelengths and frequencies and to determine if the response of internal waves are at tidal periods or at different frequencies. The atmospheric forcing provided to NCOM and meteorological data records are analyzed to define the interaction between wind forcing and internal wave generation. Wavelet analysis characterizes the ocean response to atmospheric events with periodic frequencies. Ocean color satellite imagery was used to visualize the location of the Mississippi river plume (and other oceanic features) and compared to the model predictions because the enhanced stratification from freshwater plumes which propagate across the Mississippi Bight can provide favorable conditions in coastal waters for internal wave generation and propagation. The findings of this study will provide insight about the internal wave dynamics in the Gulf of Mexico and their potential impact on the marine ecosystem.

Investigation of inner aerodynamics of the four-vortex furnace model

NASA Astrophysics Data System (ADS)

Anufriev, I. S.; Shadrin, E. Yu; Sharypov, O. V.

2018-03-01

The internal aerodynamics of a perspective vortex furnace chamber of a pulverized coal boiler with a diagonal arrangement of burners is studied using the non-contact optical method of flow diagnostics. The results of laser Doppler anemometry, characterizing the complex spatial structure of a swirling flow in an isothermal laboratory model of the furnace device, are presented. The velocity distribution in the vortex chamber volume is obtained, and the flow structure in the form of four conjugate closed vortices with curved axes is visualized.

The Importance of Model Structure in the Cost-Effectiveness Analysis of Primary Care Interventions for the Management of Hypertension.

PubMed

Peñaloza-Ramos, Maria Cristina; Jowett, Sue; Sutton, Andrew John; McManus, Richard J; Barton, Pelham

2018-03-01

Management of hypertension can lead to significant reductions in blood pressure, thereby reducing the risk of cardiovascular disease. Modeling the course of cardiovascular disease is not without complications, and uncertainty surrounding the structure of a model will almost always arise once a choice of a model structure is defined. To provide a practical illustration of the impact on the results of cost-effectiveness of changing or adapting model structures in a previously published cost-utility analysis of a primary care intervention for the management of hypertension Targets and Self-Management for the Control of Blood Pressure in Stroke and at Risk Groups (TASMIN-SR). The case study assessed the structural uncertainty arising from model structure and from the exclusion of secondary events. Four alternative model structures were implemented. Long-term cost-effectiveness was estimated and the results compared with those from the TASMIN-SR model. The main cost-effectiveness results obtained in the TASMIN-SR study did not change with the implementation of alternative model structures. Choice of model type was limited to a cohort Markov model, and because of the lack of epidemiological data, only model 4 captured structural uncertainty arising from the exclusion of secondary events in the case study model. The results of this study indicate that the main conclusions drawn from the TASMIN-SR model of cost-effectiveness were robust to changes in model structure and the inclusion of secondary events. Even though one of the models produced results that were different to those of TASMIN-SR, the fact that the main conclusions were identical suggests that a more parsimonious model may have sufficed. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Structural studies of the protein endostatin in fusion with BAX BH3 death domain, a hybrid that presents enhanced antitumoral activity.

PubMed

Chura-Chambi, Rosa Maria; Arcuri, Helen Andrade; Lino, Felipe; Versati, Natan; Palma, Mario Sergio; Favaro, Denize C; Morganti, Ligia

2017-05-01

Endostatin (ES) is an antiangiogenic protein that exhibits antitumor activity in animal models. However, the activity observed in animals was not observed in human clinical trials. ES-BAX is a fusion protein composed of two functional domains: ES, which presents specificity and is internalized by activated endothelial cells and the proapoptotic BH3 domain of the protein BAX, a peptide inductor of cellular death when internalized. We have previously shown (Chura-Chambi et al., Cell Death Dis, 5, e1371, 2014) that ES-BAX presents improved antitumor activity in relation to wild-type ES. Secondary and tertiary structures of ES-BAX are similar to ES, as indicated by homology-modeling studies and molecular dynamics simulations. Tryptophan intrinsic fluorescence and circular dichroism spectroscopy corroborate these data. 15 N HSQC NMR indicates that ES-BAX is structured, but some ES residues have suffered chemical shift perturbations, suggesting that the BH3 peptide interacts with some parts of the ES protein. ES and ES-BAX present similar stability to thermal denaturation. The production of stable hybrid proteins can be a new approach to the development of therapeutic agents presenting specificity for tumoral endothelium and improved antitumor effect. © 2016 International Union of Biochemistry and Molecular Biology, Inc.

Applying Rasch model analysis in the development of the cantonese tone identification test (CANTIT).

PubMed

Lee, Kathy Y S; Lam, Joffee H S; Chan, Kit T Y; van Hasselt, Charles Andrew; Tong, Michael C F

2017-01-01

Applying Rasch analysis to evaluate the internal structure of a lexical tone perception test known as the Cantonese Tone Identification Test (CANTIT). A 75-item pool (CANTIT-75) with pictures and sound tracks was developed. Respondents were required to make a four-alternative forced choice on each item. A short version of 30 items (CANTIT-30) was developed based on fit statistics, difficulty estimates, and content evaluation. Internal structure was evaluated by fit statistics and Rasch Factor Analysis (RFA). 200 children with normal hearing and 141 children with hearing impairment were recruited. For CANTIT-75, all infit and 97% of outfit values were < 2.0. RFA revealed 40.1% of total variance was explained by the Rasch measure. The first residual component explained 2.5% of total variance in an eigenvalue of 3.1. For CANTIT-30, all infit and outfit values were < 2.0. The Rasch measure explained 38.8% of total variance, the first residual component explained 3.9% of total variance in an eigenvalue of 1.9. The Rasch model provides excellent guidance for the development of short forms. Both CANTIT-75 and CANTIT-30 possess satisfactory internal structure as a construct validity evidence in measuring the lexical tone identification ability of the Cantonese speakers.

Characterization of Slosh Damping for Ortho-Grid and Iso-Grid Internal Tank Structures

NASA Technical Reports Server (NTRS)

Westra, Douglas G.; Sansone, Marco D.; Eberhart, Chad J.; West, Jeffrey S.

2016-01-01

Grid stiffened tank structures such as Ortho-Grid and Iso-Grid are widely used in cryogenic tanks for providing stiffening to the tank while reducing mass, compared to tank walls of constant cross-section. If the structure is internal to the tank, it will positively affect the fluid dynamic behavior of the liquid propellant, in regard to fluid slosh damping. As NASA and commercial companies endeavor to explore the solar system, vehicles will by necessity become more mass efficient, and design margin will be reduced where possible. Therefore, if the damping characteristics of the Ortho-Grid and Iso-Grid structure is understood, their positive damping effect can be taken into account in the systems design process. Historically, damping by internal structures has been characterized by rules of thumb and for Ortho-Grid, empirical design tools intended for slosh baffles of much larger cross-section have been used. There is little or no information available to characterize the slosh behavior of Iso-Grid internal structure. Therefore, to take advantage of these structures for their positive damping effects, there is much need for obtaining additional data and tools to characterize them. Recently, the NASA Marshall Space Flight Center conducted both sub-scale testing and computational fluid dynamics (CFD) simulations of slosh damping for Ortho-Grid and Iso-Grid tanks for cylindrical tanks containing water. Enhanced grid meshing techniques were applied to the geometrically detailed and complex Ortho-Grid and Iso-Grid structures. The Loci-STREAM CFD program with the Volume of Fluid Method module for tracking and locating the water-air fluid interface was used to conduct the simulations. The CFD simulations were validated with the test data and new empirical models for predicting damping and frequency of Ortho-Grid and Iso-Grid structures were generated.

An Evaluation of a Theoretical Model Predicting Dieting Behaviors: Tests of Measurement and Structural Invariance across Ethnicity and Gender

ERIC Educational Resources Information Center

Boie, Ioana; Lopez, Anna L.; Sass, Daniel A.

2013-01-01

This study evaluated a model linking internalization and dieting behaviors in a sample ("n" = 499) of Latina/o and White college students. Analyses revealed that the scales were invariant across ethnic and gender groups and generally supported the invariance of the proposed model across these groups. Analyses also revealed no ethnic mean…

Effects of different loading patterns on the trabecular bone morphology of the proximal femur using adaptive bone remodeling.

PubMed

Banijamali, S Mohammad Ali; Oftadeh, Ramin; Nazarian, Ara; Goebel, Ruben; Vaziri, Ashkan; Nayeb-Hashemi, Hamid

2015-01-01

In this study, the changes in the bone density of human femur model as a result of different loadings were investigated. The model initially consisted of a solid shell representing cortical bone encompassing a cubical network of interconnected rods representing trabecular bone. A computationally efficient program was developed that iteratively changed the structure of trabecular bone by keeping the local stress in the structure within a defined stress range. The stress was controlled by either enhancing existing beam elements or removing beams from the initial trabecular frame structure. Analyses were performed for two cases of homogenous isotropic and transversely isotropic beams.Trabecular bone structure was obtained for three load cases: walking, stair climbing and stumbling without falling. The results indicate that trabecular bone tissue material properties do not have a significant effect on the converged structure of trabecular bone. In addition, as the magnitude of the loads increase, the internal structure becomes denser in critical zones. Loading associated with the stumbling results in the highest density;whereas walking, considered as a routine daily activity, results in the least internal density in different regions. Furthermore, bone volume fraction at the critical regions of the converged structure is in good agreement with previously measured data obtained from combinations of dual X-ray absorptiometry (DXA) and computed tomography (CT). The results indicate that the converged bone architecture consisting of rods and plates are consistent with the natural bone morphology of the femur. The proposed model shows a promising means to understand the effects of different individual loading patterns on the bone density.

An Engineering Tool for the Prediction of Internal Dielectric Charging

NASA Astrophysics Data System (ADS)

Rodgers, D. J.; Ryden, K. A.; Wrenn, G. L.; Latham, P. M.; Sorensen, J.; Levy, L.

1998-11-01

A practical internal charging tool has been developed. It provides an easy-to-use means for satellite engineers to predict whether on-board dielectrics are vulnerable to electrostatic discharge in the outer radiation belt. The tool is designed to simulate irradiation of single-dielectric planar or cylindrical structures with or without shielding. Analytical equations are used to describe current deposition in the dielectric. This is fast and gives charging currents to sufficient accuracy given the uncertainties in other aspects of the problem - particularly material characteristics. Time-dependent internal electric fields are calculated, taking into account the effect on conductivity of electric field, dose rate and temperature. A worst-case model of electron fluxes in the outer belt has been created specifically for the internal charging problem and is built into the code. For output, the tool gives a YES or NO decision on the susceptibility of the structure to internal electrostatic breakdown and if necessary, calculates the required changes to bring the system below the breakdown threshold. A complementary programme of laboratory irradiations has been carried out to validate the tool. The results for Epoxy-fibreglass samples show that the code models electric field realistically for a wide variety of shields, dielectric thicknesses and electron spectra. Results for Teflon samples indicate that some further experimentation is required and the radiation-induced conductivity aspects of the code have not been validated.

Reliable structural interpretation of small-angle scattering data from bio-molecules in solution--the importance of quality control and a standard reporting framework.

PubMed

Jacques, David A; Guss, Jules Mitchell; Trewhella, Jill

2012-05-17

Small-angle scattering is becoming an increasingly popular tool for the study of bio-molecular structures in solution. The large number of publications with 3D-structural models generated from small-angle solution scattering data has led to a growing consensus for the need to establish a standard reporting framework for their publication. The International Union of Crystallography recently established a set of guidelines for the necessary information required for the publication of such structural models. Here we describe the rationale for these guidelines and the importance of standardising the way in which small-angle scattering data from bio-molecules and associated structural interpretations are reported.

Factor Structure of the Revised TOEIC[R] Test: A Multiple-Sample Analysis

ERIC Educational Resources Information Center

In'nami, Yo; Koizumi, Rie

2012-01-01

This study examined the factor structure of the listening and reading sections of the revised Test of English for International Communication (TOEIC[R]) test. The data from the TOEIC IP (institutional program) test taken by 569 English learners were randomly split into two samples (n = 285 vs. 284). Four models (higher-order, correlated,…

Fermi Research Alliance LLC

Science.gov Websites

dark matter structure in universe The findings - the most accurate made of the universe's present large -scale structure - support the dark matter/dark energy model. Read More Muon g-2 Muon magnet's moment has massive international experiment. Read More Dark Energy Camera DES reveals most accurate measurement of

Langley's CSI evolutionary model: Phase O

NASA Technical Reports Server (NTRS)

Belvin, W. Keith; Elliott, Kenny B.; Horta, Lucas G.; Bailey, Jim P.; Bruner, Anne M.; Sulla, Jeffrey L.; Won, John; Ugoletti, Roberto M.

1991-01-01

A testbed for the development of Controls Structures Interaction (CSI) technology to improve space science platform pointing is described. The evolutionary nature of the testbed will permit the study of global line-of-sight pointing in phases 0 and 1, whereas, multipayload pointing systems will be studied beginning with phase 2. The design, capabilities, and typical dynamic behavior of the phase 0 version of the CSI evolutionary model (CEM) is documented for investigator both internal and external to NASA. The model description includes line-of-sight pointing measurement, testbed structure, actuators, sensors, and real time computers, as well as finite element and state space models of major components.

Parental dysphoria and children's internalizing symptoms: marital conflict styles as mediators of risk.

PubMed

Du Rocher Schudlich, Tina D; Cummings, E Mark

2003-01-01

Parents' marital conflict styles were investigated as mediators in the associations between parental dysphoria and children's internalizing symptoms. A community sample of 267 children, ages 8 to 16, participated with their parents. Behavioral observations were made of parents' interactions during marital conflict resolution tasks. Questionnaires assessed parents' dysphoria and children's internalizing problems. Structural equation modeling indicated that marital discord, in particular, depressive conflict styles, mediated the relationship between parental dysphoria and children's internalizing problems. Furthermore, whereas for dysphoric mothers, depressive conflict styles partially mediated the links with children's internalizing, for fathers, depressive conflict styles fully mediated the links. Destructive and constructive marital conflict were associated with parental dysphoria (positively and negatively, respectively) but did not mediate the relations with children's internalizing.

Sociocultural pressures, thin-ideal internalization, self-objectification, and body dissatisfaction: could feminist beliefs be a moderating factor?

PubMed

Myers, Taryn A; Crowther, Janis H

2007-09-01

Theory and research suggest that sociocultural pressures, thin-ideal internalization, and self-objectification are associated with body dissatisfaction, while feminist beliefs may serve a protective function. This research examined thin-ideal internalization and self-objectification as mediators and feminist beliefs as a moderator in the relationship between sociocultural pressures to meet the thin-ideal and body dissatisfaction. Female undergraduate volunteers (N=195) completed self-report measures assessing sociocultural influences, feminist beliefs, thin-ideal internalization, self-objectification, and body dissatisfaction. Multisample structural equation modeling showed that feminist beliefs moderate the relationship between media awareness and thin-ideal internalization, but not the relationship between social influence and thin-ideal internalization. Research and clinical implications of these findings are discussed.

Intelligent modelling of bioprocesses: a comparison of structured and unstructured approaches.

PubMed

Hodgson, Benjamin J; Taylor, Christopher N; Ushio, Misti; Leigh, J R; Kalganova, Tatiana; Baganz, Frank

2004-12-01

This contribution moves in the direction of answering some general questions about the most effective and useful ways of modelling bioprocesses. We investigate the characteristics of models that are good at extrapolating. We trained three fully predictive models with different representational structures (differential equations, differential equations with inheritance of rates and a network of reactions) on Saccharopolyspora erythraea shake flask fermentation data using genetic programming. The models were then tested on unseen data outside the range of the training data and the resulting performances were compared. It was found that constrained models with mathematical forms analogous to internal mass balancing and stoichiometric relations were superior to flexible unconstrained models, even though no a priori knowledge of this fermentation was used.

Two-step FEM-based Liver-CT registration: improving internal and external accuracy

NASA Astrophysics Data System (ADS)

Oyarzun Laura, Cristina; Drechsler, Klaus; Wesarg, Stefan

2014-03-01

To know the exact location of the internal structures of the organs, especially the vasculature, is of great importance for the clinicians. This information allows them to know which structures/vessels will be affected by certain therapy and therefore to better treat the patients. However the use of internal structures for registration is often disregarded especially in physical based registration methods. In this paper we propose an algorithm that uses finite element methods to carry out a registration of liver volumes that will not only have accuracy in the boundaries of the organ but also in the interior. Therefore a graph matching algorithm is used to find correspondences between the vessel trees of the two livers to be registered. In addition to this an adaptive volumetric mesh is generated that contains nodes in the locations in which correspondences were found. The displacements derived from those correspondences are the input for the initial deformation of the model. The first deformation brings the internal structures to their final deformed positions and the surfaces close to it. Finally, thin plate splines are used to refine the solution at the boundaries of the organ achieving an improvement in the accuracy of 71%. The algorithm has been evaluated in CT clinical images of the abdomen.

The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy.

PubMed

Mainprize, Iain L; Beniac, Daniel R; Falkovskaia, Elena; Cleverley, Robert M; Gierasch, Lila M; Ottensmeyer, F Peter; Andrews, David W

2006-12-01

Structural studies on various domains of the ribonucleoprotein signal recognition particle (SRP) have not converged on a single complete structure of bacterial SRP consistent with the biochemistry of the particle. We obtained a three-dimensional structure for Escherichia coli SRP by cryoscanning transmission electron microscopy and mapped the internal RNA by electron spectroscopic imaging. Crystallographic data were fit into the SRP reconstruction, and although the resulting model differed from previous models, they could be rationalized by movement through an interdomain linker of Ffh, the protein component of SRP. Fluorescence resonance energy transfer experiments determined interdomain distances that were consistent with our model of SRP. Docking our model onto the bacterial ribosome suggests a mechanism for signal recognition involving interdomain movement of Ffh into and out of the nascent chain exit site and suggests how SRP could interact and/or compete with the ribosome-bound chaperone, trigger factor, for a nascent chain during translation.

Recent developments in broadly applicable structure-biodegradability relationships.

PubMed

Jaworska, Joanna S; Boethling, Robert S; Howard, Philip H

2003-08-01

Biodegradation is one of the most important processes influencing concentration of a chemical substance after its release to the environment. It is the main process for removal of many chemicals from the environment and therefore is an important factor in risk assessments. This article reviews available methods and models for predicting biodegradability of organic chemicals from structure. The first section of the article briefly discusses current needs for biodegradability estimation methods related to new and existing chemicals and in the context of multimedia exposure models. Following sections include biodegradation test methods and endpoints used in modeling, with special attention given to the Japanese Ministry of International Trade and Industry test; a primer on modeling, describing the various approaches that have been used in the structure/biodegradability relationship work, and contrasting statistical and mechanistic approaches; and recent developments in structure/biodegradability relationships, divided into group contribution, chemometric, and artificial intelligence approaches.

The Interior Structure, Dynamics, and Heliospheric Impact of Reconnection-Driven Solar Coronal Hole Jets

NASA Astrophysics Data System (ADS)

Roberts, Merrill Alan

From bright loop structures and polar plumes to solar flares and coronal mass ejections (CMEs), our Sun has shown itself to be a highly dynamic star over a multitude of spatial and temporal scales. In fact, as the resolutions of our observations have improved, it has become clear that even coronal holes, the Sun's so called dark and quiet regions, are full of activity. Coronal hole (CH) jets are one example of this activity, a solar transient that occurs ubiquitously in coronal hole regions and which may contribute significant mass and energy to the corona and the solar wind. CH jets have been shown to share many properties with their larger and more energetic cousins, flares and CMEs, thereby providing an opportunity to understand these more complex and infrequent solar features. CH jets may also provide a source for microstreams and torsional Alfven waves found in the solar wind and interplanetary medium, as well as insight into basic processes for driving the fast solar wind and heating the corona. The purpose of this work is to deepen our understanding of CH jets by examining state-of-the-art fully 3D MHD simulations of CH jet eruptions. First, we investigate the internal structure and turbulent flows inside a model CH jet through an analysis of the simulation described by Karpen et al. (2017). An analysis of the radial variability within the simulated jet is performed, as well as a multi-scale turbulence analysis. We confirm the occurrence of multi-scale MHD turbulence within the model jet, and show that the resulting jet wake can be divided into three radially stratified regions based on its internal structure. Second, the 3D model space is extended to 60 solar radii and simulated encounters of the soon-to-be-launched Parker Solar Probe (PSP, Fox et al., 2016) mission with our model jet are produced and analyzed in order to identify signatures that may be seen in the eventual PSP observations. Our results suggest that PSP should encounter CH jets in situ, and that each of the three jet regions found have unique, identifiable signatures that could be detected by PSP. These findings suggest that CH jets are internally complex, with multi-scale, radially stratified internal structure which evolves as the jet progresses through the heliosphere. PSP will have a unique opportunity to observe this newly predicted and previously unobserved fine structure when it descends into the corona in the 2020s, and our results will serve to interpret the PSP data, as well as provide a means to test the validity of our model by comparison with them.

Modelling the Interior Structure of Enceladus Based on the 2014's Cassini Gravity Data.

PubMed

Taubner, R-S; Leitner, J J; Firneis, M G; Hitzenberger, R

2016-06-01

We present a model for the internal structure of Saturn's moon Enceladus. This model allows us to estimate the physical conditions at the bottom of the satellite's potential subsurface water reservoir and to determine the radial distribution of pressure and gravity. This leads to a better understanding of the physical and chemical conditions at the water/rock boundary. This boundary is the most promising area on icy moons for astrobiological studies as it could serve as a potential habitat for extraterrestrial life similar to terrestrial microbes that inhabit rocky mounds on Earth's sea floors.

Significance of modeling internal damping in the control of structures

NASA Technical Reports Server (NTRS)

Banks, H. T.; Inman, D. J.

1992-01-01

Several simple systems are examined to illustrate the importance of the estimation of damping parameters in closed-loop system performance and stability. The negative effects of unmodeled damping are particularly pronounced in systems that do not use collocated sensors and actuators. An example is considered for which even the actuators (a tip jet nozzle and flexible hose) for a simple beam produce significant damping which, if ignored, results in a model that cannot yield a reasonable time response using physically meaningful parameter values. It is concluded that correct damping modeling is essential in structure control.

Automated extraction of knowledge for model-based diagnostics

NASA Technical Reports Server (NTRS)

Gonzalez, Avelino J.; Myler, Harley R.; Towhidnejad, Massood; Mckenzie, Frederic D.; Kladke, Robin R.

1990-01-01

The concept of accessing computer aided design (CAD) design databases and extracting a process model automatically is investigated as a possible source for the generation of knowledge bases for model-based reasoning systems. The resulting system, referred to as automated knowledge generation (AKG), uses an object-oriented programming structure and constraint techniques as well as internal database of component descriptions to generate a frame-based structure that describes the model. The procedure has been designed to be general enough to be easily coupled to CAD systems that feature a database capable of providing label and connectivity data from the drawn system. The AKG system is capable of defining knowledge bases in formats required by various model-based reasoning tools.

The German version of the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): psychometric properties and diagnostic utility.

PubMed

Krüger-Gottschalk, Antje; Knaevelsrud, Christine; Rau, Heinrich; Dyer, Anne; Schäfer, Ingo; Schellong, Julia; Ehring, Thomas

2017-11-28

The Posttraumatic Stress Disorder (PTSD) Checklist (PCL, now PCL-5) has recently been revised to reflect the new diagnostic criteria of the disorder. A clinical sample of trauma-exposed individuals (N = 352) was assessed with the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) and the PCL-5. Internal consistencies and test-retest reliability were computed. To investigate diagnostic accuracy, we calculated receiver operating curves. Confirmatory factor analyses (CFA) were performed to analyze the structural validity. Results showed high internal consistency (α = .95), high test-retest reliability (r = .91) and a high correlation with the total severity score of the CAPS-5, r = .77. In addition, the recommended cutoff of 33 on the PCL-5 showed high diagnostic accuracy when compared to the diagnosis established by the CAPS-5. CFAs comparing the DSM-5 model with alternative models (the three-factor solution, the dysphoria, anhedonia, externalizing behavior and hybrid model) to account for the structural validity of the PCL-5 remained inconclusive. Overall, the findings show that the German PCL-5 is a reliable instrument with good diagnostic accuracy. However, more research evaluating the underlying factor structure is needed.

A Study into the Impact of Physical Structures on the Runway Velocity Field at the Atlantic City International Airport

NASA Astrophysics Data System (ADS)

King, David, Jr.; Manson, Russell; Trout, Joseph; Decicco, Nicholas; Rios, Manny

2015-04-01

Wake vortices are generated by airplanes in flight. These vortices decay slowly and may persist for several minutes after their creation. These vortices and associated smaller scale turbulent structures present a hazard to incoming flights. It is for this reason that incoming flights are timed to arrive after these vortices have dissipated. Local weather conditions, mainly prevailing winds, can affect the transport and evolution of these vortices; therefore, there is a need to fully understand localized wind patterns at the airport-sized mircoscale. Here we have undertaken a computational investigation into the impacts of localized wind flows and physical structures on the velocity field at Atlantic City International Airport. The simulations are undertaken in OpenFOAM, an open source computational fluid dynamics software package, using an optimized geometric mesh of the airport. Initial conditions for the simulations are based on historical data with the option to run simulations based on projected weather conditions imported from the Weather Research & Forcasting (WRF) Model. Sub-grid scale turbulence is modeled using a Large Eddy Simulation (LES) approach. The initial results gathered from the WRF Model simulations and historical weather data analysis are presented elsewhere.

Effects of Oblique Extension and Inherited Structure Geometry on Transfer Zone Development in Continental Rifts: A 4D Analogue Modeling Approach

NASA Astrophysics Data System (ADS)

Zwaan, Frank; Schreurs, Guido

2015-04-01

INTRODUCTION Inherited structures in the crust form weak zones along which deformation will focus during rifting. Along-strike connection of rift segments may occur along transfer zones, as observed in East Africa. Previous studies have focused on numerical and analog modeling of transfer zones (e.g. Acocella et al., 1999, Allken et al., 2012). We elaborate upon those by investigating the effects of 1) oblique extension and 2) the geometry of linked and non-linked inherited structures on the development of transfer zones. A further improvement is the use of X-ray Computer Tomography (CT) for detailed internal analysis. METHODS The experimental set-up (see Schreurs & Colleta, 1998) contains two sidewalls with a base of compressed foam and plexiglass bars stacked in between. Decompressing this base results in distributed deformation of the overlying model materials. Deforming the model laterally with a mobile base plate produces the strike-slip components for oblique extension. Divergence velocities are in the order of 5 mm/h, translating to ca. 5 mm/Ma in nature, and 1 cm represents 10 km. A 2 cm thick layer of viscous silicone represents the ductile lower crust and a 2 cm quartz sand layer the brittle upper crust. Inherited structures are created with thin lines of silicon laid down on top of the basal silicone layer. Several models were run in a CT-scanner to reveal the 3D evolution of internal structures with time, hence 4D. RESULTS Localization of deformation along the pre-defined structures works well. The models show that the structural style changes with extension obliquity, from wide rift structures to narrower rifts with internal oblique-slip and finally strike-slip structures. Furthermore, rift offset is an important parameter influencing the occurrence of linkage: increasing rift offset decreases linkage as previously observed by Allken et al. (2012). However, increasing divergence obliquity promotes transfer zone formation, as does the presence of rift-connecting inherited zones, whose strike is at an angle of >15° with respect to the divergence direction. CT-analysis indicates that faulting initiated shortly after the start of the experiments, while structures become only clearly visible at the surface only after 1:30h (4% extension). Rift boundary fault angles tend to decrease from an initial 70° to ca. 55° after 4:00h (10% extension). Further CT-analysis will reveal the 3D evolution of the transform zones in more detail. REFERENCES Acocella, V., Faccenna, C., Funiciello, R., Rossetti, F., 1999. Sand-box modelling of basement-controlled transfer zones in extensional domains. Terra Nova, Vol. 11, No. 4, pp 149-156 Allken, V., Huismans, R. S., Thieulot, C., 2012. Factors controlling the mode of rift interaction in brittle-ductile coupled systems: A 3D numerical study, Geochem. Geophys. Geosyst. Vol. 13, Q05010 Schreurs, G., Colletta, B. (1998) Analogue modelling of faulting in zones of continental transpression and transtension. In: Holdsworth, R. E., Strachan R. A., Dewey, J. F., (eds.) 1998. Continental Transpressional and Transtensional Tectonics. Geological Society, London, Special Publications. No. 135, pp 59-79

Probabilistic model of ligaments and tendons: quasistatic linear stretching.

PubMed

Bontempi, M

2009-03-01

Ligaments and tendons have a significant role in the musculoskeletal system and are frequently subjected to injury. This study presents a model of collagen fibers, based on the study of a statistical distribution of fibers when they are subjected to quasistatic linear stretching. With respect to other methodologies, this model is able to describe the behavior of the bundle using less ad hoc hypotheses and is able to describe all the quasistatic stretch-load responses of the bundle, including the yield and failure regions described in the literature. It has two other important results: the first is that it is able to correlate the mechanical behavior of the bundle with its internal structure, and it suggests a methodology to deduce the fibers population distribution directly from the tensile-test data. The second is that it can follow fibers' structure evolution during the stretching and it is possible to study the internal adaptation of fibers in physiological and pathological conditions.

Probabilistic model of ligaments and tendons: Quasistatic linear stretching

NASA Astrophysics Data System (ADS)

Bontempi, M.

2009-03-01

Ligaments and tendons have a significant role in the musculoskeletal system and are frequently subjected to injury. This study presents a model of collagen fibers, based on the study of a statistical distribution of fibers when they are subjected to quasistatic linear stretching. With respect to other methodologies, this model is able to describe the behavior of the bundle using less ad hoc hypotheses and is able to describe all the quasistatic stretch-load responses of the bundle, including the yield and failure regions described in the literature. It has two other important results: the first is that it is able to correlate the mechanical behavior of the bundle with its internal structure, and it suggests a methodology to deduce the fibers population distribution directly from the tensile-test data. The second is that it can follow fibers’ structure evolution during the stretching and it is possible to study the internal adaptation of fibers in physiological and pathological conditions.

Differential Relations of Depression and Social Anxiety Symptoms to the Facets of Extraversion/Positive Emotionality

PubMed Central

Naragon-Gainey, Kristin; Watson, David; Markon, Kristian E.

2009-01-01

Previous research has shown that depression and social anxiety—two “facets” of internalizing psychopathology— both are characterized by low levels of extraversion/positive emotionality (E/PE). However, little is known about the relations of the facets of E/PE with symptoms of depression and social anxiety. This study utilized multiple measures of each facet of E/PE, as well as depression and social anxiety symptoms. Self-report data were collected from large samples of college students and psychiatric outpatients. Separate factor analyses in each sample revealed a four-factor structure of E/PE, consisting of Sociability, Positive Emotionality, Ascendance, and Fun-Seeking. Structural equation modeling revealed that, after controlling for the higher-order internalizing factor and the overlap among the E/PE facets, social anxiety was broadly related to all four facets of E/PE, whereas depression was strongly related only to low positive emotionality. Implications for hierarchical models of personality and psychopathology, assessment and treatment, and etiological models are discussed. PMID:19413405

Structure coefficients for different initial metallicities for use in stellar analysis

NASA Astrophysics Data System (ADS)

Inlek, Gulay; Budding, Edwin; Demircan, Osman

2017-09-01

Internal structure coefficients for zero age Main Sequence (ZAMS) model stars with different initial metallicities are presented. A series of (Eggleton) stellar models with masses between 1-40 M_{⊙} and metallicities Z=0.0001, Z=0.001, Z=0.004, Z=0.01, Z=0.02, and Z=0.03 were used. We have also calculated the same coefficients for a recommended solar metallicity value Z=0.0134 (Asplund et al. in Annu. Rev. Astron. Astrophys. 47:481, 2009). For each model, values of the internal structure constants k2, k3, k4 and related coefficients have been derived by numerically integrating Radau's equation with the (FORTRAN) program RADAU. The (Eggleton) stellar models used come from the ` EZ-Web' compilation of the Dept. of Astronomy, University of Wisconsin, Madison. The calculations follow the procedure given by Inlek and Budding (Astrophys. Space Sci. 342:365, 2012). These new results were compared with others in the literature. We deduce that the current state of theoretical evaluation of structure coefficients is generally in sufficient agreement with data obtained from apsidal advance rates of selected well-observed eccentric eclipsing binary stars at the present time, given the probable errors of the latter. However, new results coming from more precise and extensive data sets in the wake of the Kepler Mission, or similar future surveys, may call for further theoretical specification or refinement. The derivation of structure coefficients from observations of apsidal motion in close eccentric binary systems requires specification of relevant parameters from light curve analysis. A self-consistent treatment then implies inclusion of the structure coefficients within the fitting function of such analysis.

Automated classification of RNA 3D motifs and the RNA 3D Motif Atlas

PubMed Central

Petrov, Anton I.; Zirbel, Craig L.; Leontis, Neocles B.

2013-01-01

The analysis of atomic-resolution RNA three-dimensional (3D) structures reveals that many internal and hairpin loops are modular, recurrent, and structured by conserved non-Watson–Crick base pairs. Structurally similar loops define RNA 3D motifs that are conserved in homologous RNA molecules, but can also occur at nonhomologous sites in diverse RNAs, and which often vary in sequence. To further our understanding of RNA motif structure and sequence variability and to provide a useful resource for structure modeling and prediction, we present a new method for automated classification of internal and hairpin loop RNA 3D motifs and a new online database called the RNA 3D Motif Atlas. To classify the motif instances, a representative set of internal and hairpin loops is automatically extracted from a nonredundant list of RNA-containing PDB files. Their structures are compared geometrically, all-against-all, using the FR3D program suite. The loops are clustered into motif groups, taking into account geometric similarity and structural annotations and making allowance for a variable number of bulged bases. The automated procedure that we have implemented identifies all hairpin and internal loop motifs previously described in the literature. All motif instances and motif groups are assigned unique and stable identifiers and are made available in the RNA 3D Motif Atlas (http://rna.bgsu.edu/motifs), which is automatically updated every four weeks. The RNA 3D Motif Atlas provides an interactive user interface for exploring motif diversity and tools for programmatic data access. PMID:23970545

A Monte Carlo model for the internal dosimetry of choroid plexuses in nuclear medicine procedures.

PubMed

Amato, Ernesto; Cicone, Francesco; Auditore, Lucrezia; Baldari, Sergio; Prior, John O; Gnesin, Silvano

2018-05-01

Choroid plexuses are vascular structures located in the brain ventricles, showing specific uptake of some diagnostic and therapeutic radiopharmaceuticals currently under clinical investigation, such as integrin-binding arginine-glycine-aspartic acid (RGD) peptides. No specific geometry for choroid plexuses has been implemented in commercially available software for internal dosimetry. The aims of the present study were to assess the dependence of absorbed dose to the choroid plexuses on the organ geometry implemented in Monte Carlo simulations, and to propose an analytical model for the internal dosimetry of these structures for 18 F, 64 Cu, 67 Cu, 68 Ga, 90 Y, 131 I and 177 Lu nuclides. A GAMOS Monte Carlo simulation based on direct organ segmentation was taken as the gold standard to validate a second simulation based on a simplified geometrical model of the choroid plexuses. Both simulations were compared with the OLINDA/EXM sphere model. The gold standard and the simplified geometrical model gave similar dosimetry results (dose difference < 3.5%), indicating that the latter can be considered as a satisfactory approximation of the real geometry. In contrast, the sphere model systematically overestimated the absorbed dose compared to both Monte Carlo models (range: 4-50% dose difference), depending on the isotope energy and organ mass. Therefore, the simplified geometric model was adopted to introduce an analytical approach for choroid plexuses dosimetry in the mass range 2-16 g. The proposed model enables the estimation of the choroid plexuses dose by a simple bi-parametric function, once the organ mass and the residence time of the radiopharmaceutical under investigation are provided. Copyright © 2018 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Seasonal variability of Internal tide energetics in the western Bay of Bengal

NASA Astrophysics Data System (ADS)

Mohanty, S.; Rao, A. D.

2017-12-01

The Internal Waves (IWs) are generated by the flow of barotropic tide over the rapidly varying and steep topographic features like continental shelf slope, seamounts, etc. These waves are an important phenomena in the ocean due to their influence on the density structure and energy transfer into the region. Such waves are also important in submarine acoustics, underwater navigation, offshore structures, ocean mixing and biogeochemical processes, etc. over the shelf-slope region. The seasonal variability of internal tides in the western Bay of Bengal is examined by using three-dimensional MITgcm model. The numerical simulations are performed for different periods covering August-September, 2013; November-December, 2013 and March-April, 2014 representing monsoon, post-monsoon and pre-monsoon seasons respectively during which high temporal resolution observed data sets are available. The model is initially validated through the spectral estimate of density and the baroclinic velocities. From the estimate, it is found that its peak is associated with the semi-diurnal frequency at all the depths in both observations and model simulations for November-December and March-April. However in August, the estimate is found to be maximum near the inertial frequency at all available depths. EOF analysis suggests that about 70-80% of the total variance comes from Mode-1 semi-diurnal internal tide in both observations as well as in the model simulations. The phase speed, group speed and wavelength are found to be maximum for post-monsoon season compared to other two seasons. To understand the generation and propagation of internal tides over this region, barotropic-to-baroclinic M2 tidal energy conversion and energy flux are examined. The barotropic-to-baroclinic conversion occurs intensively along the shelf-slope regions and propagate towards the coast. The model simulated energy dissipation rate infers that its maximum occurs at the generation sites and hence the local mixing due to internal tide is maximum at these sites. The spatial distribution of available potential energy is found to be maximum in November (20kg/m2) in northern BoB and minimum in August (14kg/m2). The detailed energy budget calculation are made for all the seasons and results are analysed.

Predicting human skin absorption of chemicals: development of a novel quantitative structure activity relationship.

PubMed

Luo, Wen; Medrek, Sarah; Misra, Jatin; Nohynek, Gerhard J

2007-02-01

The objective of this study was to construct and validate a quantitative structure-activity relationship model for skin absorption. Such models are valuable tools for screening and prioritization in safety and efficacy evaluation, and risk assessment of drugs and chemicals. A database of 340 chemicals with percutaneous absorption was assembled. Two models were derived from the training set consisting 306 chemicals (90/10 random split). In addition to the experimental K(ow) values, over 300 2D and 3D atomic and molecular descriptors were analyzed using MDL's QsarIS computer program. Subsequently, the models were validated using both internal (leave-one-out) and external validation (test set) procedures. Using the stepwise regression analysis, three molecular descriptors were determined to have significant statistical correlation with K(p) (R2 = 0.8225): logK(ow), X0 (quantification of both molecular size and the degree of skeletal branching), and SsssCH (count of aromatic carbon groups). In conclusion, two models to estimate skin absorption were developed. When compared to other skin absorption QSAR models in the literature, our model incorporated more chemicals and explored a large number of descriptors. Additionally, our models are reasonably predictive and have met both internal and external statistical validations.

Higher Education as an Extended Duration Service: An Investigation of the Determinants of Vietnamese Overseas Student Loyalty

ERIC Educational Resources Information Center

Pham, Hiep-Hung; Lai, Sue Ling

2016-01-01

Regarding higher education as a type of extended duration service, this article proposes a framework considering adjusted expectation, disconfirmation, satisfaction, and commitment in a conceptual model to explain international student loyalty. Employing a structure equation model to the sample data collected from 252 Vietnam overseas students…

The Employee Satisfaction Inventory (ESI): Development of a Scale to Measure Satisfaction of Greek Employees.

ERIC Educational Resources Information Center

Koustelios, Athanasios D.; Bagiatis, Konstantinos

1997-01-01

An instrument to measure employee job satisfaction in Greece was developed and tested with 212 and 516 employees. Exploratory factor analysis indicated a six-factor solution with high internal consistency. Structural equation modeling showed a fairly good fit to the model, with need for slight improvement. (SLD)

A New Three-Dimensional Educational Model Kit for Building DNA and RNA Molecules: Development and Evaluation

ERIC Educational Resources Information Center

Beltramini, Leila Maria; Araujo, Ana Paula Ulian; de Oliveira, Tales Henrique Goncalves; dos Santos Abel, Luciano Douglas; da Silva, Aparecido Rodrigues; dos Santos, Neusa Fernandes

2006-01-01

International specialized literature focused on research in biology education is sadly scarce, especially regarding biochemical and molecular aspects. In this light, researchers from this Centre for Structural Molecular Biotechnology developed and evaluated a three-dimensional educational model named "Building Life Molecules DNA and RNA." The…

The Influence of Internal Structures in Fused Deposition Modeling Method on Dimensional Accuracy of Components

NASA Astrophysics Data System (ADS)

Milde, Ján; Morovič, Ladislav

2016-09-01

The paper investigates the influence of infill (internal structures of components) in the Fused Deposition Modeling (FDM) method on dimensional and geometrical accuracy of components. The components in this case were real models of human mandible, which were obtained by Computed Tomography (CT) mostly used in medical applications. In the production phase, the device used for manufacturing, was a 3D printer Zortrax M200 based on the FDM technology. In the second phase, the mandibles made by the printer, were digitized using optical scanning device of GOM ATOS Triple Scan II. They were subsequently evaluated in the final phase. The practical part of this article describes the procedure of jaw model modification, the production of components using a 3D printer, the procedure of digitization of printed parts by optical scanning device and the procedure of comparison. The outcome of this article is a comparative analysis of individual printed parts, containing tables with mean deviations for individual printed parts, as well as tables for groups of printed parts with the same infill parameter.

The Composition and Thermal State of Mars

NASA Astrophysics Data System (ADS)

Khan, A.; Connolly, J.

Previous studies concerning the internal composition and constitution of Mars are essentially limited to forward modeling of some relatively simple models of the martian internal structure and therefore provide little information on what we can actually learn from the data. In view of the limitations inherent in forward models, we propose to invert a number of geophysical data to directly constrain the martian composition and thermal state. The inverse method employed here is general and provides through the unified description of phase equilibria a way of constructing planetary models where the radial variation of mineralogy and physical structure with pressure and temperature is naturally specified, allowing us to directly invert for chemical composition and temperature. Given these parameters mineralogy, Mg# (MgO/(MgO+FeO)) and bulk physical properties can be calculated. The approach used here has recently been applied successfully to the Moon and Earth in analyses of both eletromagnetic sounding as well as seismic data. The data used in the inversion are, mean moment of inertia, mean density, second degree tidal Love number, tidal dissipation factor and of course mean radius.

Modeling and Reconstruction of Micro-structured 3D Chitosan/Gelatin Porous Scaffolds Using Micro-CT

NASA Astrophysics Data System (ADS)

Gong, Haibo; Li, Dichen; He, Jiankang; Liu, Yaxiong; Lian, Qin; Zhao, Jinna

2008-09-01

Three dimensional (3D) channel networks are the key to promise the uniform distribution of nutrients inside 3D hepatic tissue engineering scaffolds and prompt elimination of metabolic products out of the scaffolds. 3D chitosan/gelatin porous scaffolds with predefined internal channels were fabricated and a combination of light microscope, laser confocal microscopy and micro-CT were employed to characterize the structure of porous scaffolds. In order to evaluate the flow field distribution inside the micro-structured 3D scaffolds, a computer reconstructing method based on Micro-CT was proposed. According to this evaluating method, a contrast between 3D porous scaffolds with and without predefined internal channels was also performed to assess scaffolds' fluid characters. Results showed that the internal channel of the 3D scaffolds formed the 3D fluid channel network; the uniformity of flow field distribution of the scaffolds fabricated in this paper was better than the simple porous scaffold without micro-fluid channels.

Tribute to the contribution of Gerard Lallenment to structural dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Los Alamos National Laboratory

The Society for Experimental Mechanics and the International Modal Analysis Conference recognize the remarkable contribution to experimental mechanics, mechanical engineering and structural dynamics of Professor Gerard Lallement, from the University of Franche-Comte, France. A special session is organized during the IMAC-XX to outline the many achievements of Gerard Lallement in the fields of modal analysis, structural system identification, the theory and practice of structural modification, component mode synthesis and finite element model updating. The purpose of this publication is not to provide an exhaustive account of Gerard Lallement's contribution to structural dynamics. Numerous references are provided that should help themore » interested reader learn more about the many aspects of his work. Instead, the significance of this work is illustrated by discussing the role of structural dynamics in industrial applications and its future challenges. The technical aspects of Gerard Lallement's work are illustrated with a discussion of structural modification, modeling error localization and model updating.« less

An innovative methodology for measurement of stress distribution of inflatable membrane structures

NASA Astrophysics Data System (ADS)

Zhao, Bing; Chen, Wujun; Hu, Jianhui; Chen, Jianwen; Qiu, Zhenyu; Zhou, Jinyu; Gao, Chengjun

2016-02-01

The inflatable membrane structure has been widely used in the fields of civil building, industrial building, airship, super pressure balloon and spacecraft. It is important to measure the stress distribution of the inflatable membrane structure because it influences the safety of the structural design. This paper presents an innovative methodology for the measurement and determination of the stress distribution of the inflatable membrane structure under different internal pressures, combining photogrammetry and the force-finding method. The shape of the inflatable membrane structure is maintained by the use of pressurized air, and the internal pressure is controlled and measured by means of an automatic pressure control system. The 3D coordinates of the marking points pasted on the membrane surface are acquired by three photographs captured from three cameras based on photogrammetry. After digitizing the markings on the photographs, the 3D curved surfaces are rebuilt. The continuous membrane surfaces are discretized into quadrilateral mesh and simulated by membrane links to calculate the stress distributions using the force-finding method. The internal pressure is simplified to the external node forces in the normal direction according to the contributory area of the node. Once the geometry x, the external force r and the topology C are obtained, the unknown force densities q in each link can be determined. Therefore, the stress distributions of the inflatable membrane structure can be calculated, combining the linear adjustment theory and the force density method based on the force equilibrium of inflated internal pressure and membrane internal force without considering the mechanical properties of the constitutive material. As the use of the inflatable membrane structure is attractive in the field of civil building, an ethylene-tetrafluoroethylene (ETFE) cushion is used with the measurement model to validate the proposed methodology. The comparisons between the obtained results and numerical simulation for the inflation process of the ETFE cushion are performed, and the strong agreements demonstrate that the proposed methodology is feasible and accurate.

Internal Flow Thermal/Fluid Modeling of STS-107 Port Wing in Support of the Columbia Accident Investigation Board

NASA Technical Reports Server (NTRS)

Sharp, John R.; Kittredge, Ken; Schunk, Richard G.

2003-01-01

As part of the aero-thermodynamics team supporting the Columbia Accident Investigation Board (CAB), the Marshall Space Flight Center was asked to perform engineering analyses of internal flows in the port wing. The aero-thermodynamics team was split into internal flow and external flow teams with the support being divided between shorter timeframe engineering methods and more complex computational fluid dynamics. In order to gain a rough order of magnitude type of knowledge of the internal flow in the port wing for various breach locations and sizes (as theorized by the CAB to have caused the Columbia re-entry failure), a bulk venting model was required to input boundary flow rates and pressures to the computational fluid dynamics (CFD) analyses. This paper summarizes the modeling that was done by MSFC in Thermal Desktop. A venting model of the entire Orbiter was constructed in FloCAD based on Rockwell International s flight substantiation analyses and the STS-107 reentry trajectory. Chemical equilibrium air thermodynamic properties were generated for SINDA/FLUINT s fluid property routines from a code provided by Langley Research Center. In parallel, a simplified thermal mathematical model of the port wing, including the Thermal Protection System (TPS), was based on more detailed Shuttle re-entry modeling previously done by the Dryden Flight Research Center. Once the venting model was coupled with the thermal model of the wing structure with chemical equilibrium air properties, various breach scenarios were assessed in support of the aero-thermodynamics team. The construction of the coupled model and results are presented herein.

Mission Analysis Program for Solar Electric Propulsion (MAPSEP). Volume 3: Program manual

NASA Technical Reports Server (NTRS)

Huling, K. R.; Boain, R. J.; Wilson, T.; Hong, P. E.; Shults, G. L.

1974-01-01

The internal structure of MAPSEP is described. Topics discussed include: macrologic, variable definition, subroutines, and logical flow. Information is given to facilitate modifications to the models and algorithms of MAPSEP.

Evaluating Individual Students' Perceptions of Instructional Quality: An Investigation of their Factor Structure, Measurement Invariance, and Relations to Educational Outcomes.

PubMed

Scherer, Ronny; Nilsen, Trude; Jansen, Malte

2016-01-01

Students' perceptions of instructional quality are among the most important criteria for evaluating teaching effectiveness. The present study evaluates different latent variable modeling approaches (confirmatory factor analysis, exploratory structural equation modeling, and bifactor modeling), which are used to describe these individual perceptions with respect to their factor structure, measurement invariance, and the relations to selected educational outcomes (achievement, self-concept, and motivation in mathematics). On the basis of the Programme for International Student Assessment (PISA) 2012 large-scale data sets of Australia, Canada, and the USA (N = 26,746 students), we find support for the distinction between three factors of individual students' perceptions and full measurement invariance across countries for all modeling approaches. In this regard, bifactor exploratory structural equation modeling outperformed alternative approaches with respect to model fit. Our findings reveal significant relations to the educational outcomes. This study synthesizes different modeling approaches of individual students' perceptions of instructional quality and provides insights into the nature of these perceptions from an individual differences perspective. Implications for the measurement and modeling of individually perceived instructional quality are discussed.

Dynamics of hydrated mucopolysaccharides in cartilaginous tissues treated by laser radiation

NASA Astrophysics Data System (ADS)

Omelchenko, Alexander I.; Sobol, Emil N.; Ignatieva, Natalia Y.; Lunin, Valerii V.; Jumel, Kornelia; Harding, Stephen E.; Jones, Nicholas

2001-05-01

Dynamic mechanical properties of hydrated mucopolysaccharides have been studied in heated solutions by means of molecular hydrodynamic and acoustic techniques. These experiments model the thermal condition used for laser reshaping of cartilage. It has been shown that elastic modulus and internal friction depends on concentration of chondroitine sulphate in the solution and temperature. Maximum of internal friction was revealed at about 40 degree(s)C that corresponds to temperature of breakdown of hydrophobic bonds. Temperature dependence of internal friction manifests structural changes in polysaccharides molecules under laser heating.

Mechanistic modeling of the loss of protein sieving due to internal and external fouling of microfilters.

PubMed

Bolton, Glen R; Apostolidis, Alex J

2017-09-01

Fed-batch and perfusion cell culture processes used to produce therapeutic proteins can use microfilters for product harvest. In this study, new explicit mathematical models of sieving loss due to internal membrane fouling, external membrane fouling, or a combination of the two were generated. The models accounted for membrane and cake structures and hindered solute transport. Internal membrane fouling was assumed to occur due to the accumulation of foulant on either membrane pore walls (pore-retention model) or membrane fibers (fiber-retention model). External cake fouling was assumed to occur either by the growth of a single incompressible cake layer (cake-growth) or by the accumulation of a number of independent cake layers (cake-series). The pore-retention model was combined with either the cake-series or cake-growth models to obtain models that describe internal and external fouling occurring either simultaneously or sequentially. The models were tested using well-documented sieving decline data available in the literature. The sequential pore-retention followed by cake-growth model provided a good fit of sieving decline data during beer microfiltration. The cake-series and cake-growth models provided good fits of sieving decline data during the microfiltration of a perfusion cell culture. The new models provide insights into the mechanisms of fouling that result in the loss of product sieving. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1323-1333, 2017. © 2017 American Institute of Chemical Engineers.

Efficient High-Fidelity, Geometrically Exact, Multiphysics Structural Models

DTIC Science & Technology

2011-10-14

fuctionally graded core. International Journal for Numerical Methods in Engineering, 68:940– 966, 2006. 7F. Shang, Z. Wang, and Z. Li. Analysis of...normal deformable plate theory and MLPG method with radial basis fuctions . Composite Structures, 80:539– 552, 2007. 17W. Zhen and W. Chen. A higher-order...functionally graded plates by using higher-order shear and normal deformable plate theory and MLPG method with radial basis fuctions . Composite Structures, 80

Forecasting VaR and ES of stock index portfolio: A Vine copula method

NASA Astrophysics Data System (ADS)

Zhang, Bangzheng; Wei, Yu; Yu, Jiang; Lai, Xiaodong; Peng, Zhenfeng

2014-12-01

Risk measurement has both theoretical and practical significance in risk management. Using daily sample of 10 international stock indices, firstly this paper models the internal structures among different stock markets with C-Vine, D-Vine and R-Vine copula models. Secondly, the Value-at-Risk (VaR) and Expected Shortfall (ES) of the international stock markets portfolio are forecasted using Monte Carlo method based on the estimated dependence of different Vine copulas. Finally, the accuracy of VaR and ES measurements obtained from different statistical models are evaluated by UC, IND, CC and Posterior analysis. The empirical results show that the VaR forecasts at the quantile levels of 0.9, 0.95, 0.975 and 0.99 with three kinds of Vine copula models are sufficiently accurate. Several traditional methods, such as historical simulation, mean-variance and DCC-GARCH models, fail to pass the CC backtesting. The Vine copula methods can accurately forecast the ES of the portfolio on the base of VaR measurement, and D-Vine copula model is superior to other Vine copulas.

Network evolution model for supply chain with manufactures as the core.

PubMed

Fang, Haiyang; Jiang, Dali; Yang, Tinghong; Fang, Ling; Yang, Jian; Li, Wu; Zhao, Jing

2018-01-01

Building evolution model of supply chain networks could be helpful to understand its development law. However, specific characteristics and attributes of real supply chains are often neglected in existing evolution models. This work proposes a new evolution model of supply chain with manufactures as the core, based on external market demand and internal competition-cooperation. The evolution model assumes the external market environment is relatively stable, considers several factors, including specific topology of supply chain, external market demand, ecological growth and flow conservation. The simulation results suggest that the networks evolved by our model have similar structures as real supply chains. Meanwhile, the influences of external market demand and internal competition-cooperation to network evolution are analyzed. Additionally, 38 benchmark data sets are applied to validate the rationality of our evolution model, in which, nine manufacturing supply chains match the features of the networks constructed by our model.

Network evolution model for supply chain with manufactures as the core

PubMed Central

Jiang, Dali; Fang, Ling; Yang, Jian; Li, Wu; Zhao, Jing

2018-01-01

Building evolution model of supply chain networks could be helpful to understand its development law. However, specific characteristics and attributes of real supply chains are often neglected in existing evolution models. This work proposes a new evolution model of supply chain with manufactures as the core, based on external market demand and internal competition-cooperation. The evolution model assumes the external market environment is relatively stable, considers several factors, including specific topology of supply chain, external market demand, ecological growth and flow conservation. The simulation results suggest that the networks evolved by our model have similar structures as real supply chains. Meanwhile, the influences of external market demand and internal competition-cooperation to network evolution are analyzed. Additionally, 38 benchmark data sets are applied to validate the rationality of our evolution model, in which, nine manufacturing supply chains match the features of the networks constructed by our model. PMID:29370201

Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling.

PubMed

Kumar, Gyanendra; Kumaran, Desigan; Ahmed, S Ashraf; Swaminathan, Subramanyam

2012-05-01

Clostridium botulinum neurotoxins are classified as Category A bioterrorism agents by the Centers for Disease Control and Prevention (CDC). The seven serotypes (A-G) of the botulinum neurotoxin, the causative agent of the disease botulism, block neurotransmitter release by specifically cleaving one of the three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins and induce flaccid paralysis. Using a structure-based drug-design approach, a number of peptide inhibitors were designed and their inhibitory activity against botulinum serotype A (BoNT/A) protease was determined. The most potent peptide, RRGF, inhibited BoNT/A protease with an IC(50) of 0.9 µM and a K(i) of 358 nM. High-resolution crystal structures of various peptide inhibitors in complex with the BoNT/A protease domain were also determined. Based on the inhibitory activities and the atomic interactions deduced from the cocrystal structures, the structure-activity relationship was analyzed and a pharmacophore model was developed. Unlike the currently available models, this pharmacophore model is based on a number of enzyme-inhibitor peptide cocrystal structures and improved the existing models significantly, incorporating new features. © 2012 International Union of Crystallography

Mixture models for protein structure ensembles.

PubMed

Hirsch, Michael; Habeck, Michael

2008-10-01

Protein structure ensembles provide important insight into the dynamics and function of a protein and contain information that is not captured with a single static structure. However, it is not clear a priori to what extent the variability within an ensemble is caused by internal structural changes. Additional variability results from overall translations and rotations of the molecule. And most experimental data do not provide information to relate the structures to a common reference frame. To report meaningful values of intrinsic dynamics, structural precision, conformational entropy, etc., it is therefore important to disentangle local from global conformational heterogeneity. We consider the task of disentangling local from global heterogeneity as an inference problem. We use probabilistic methods to infer from the protein ensemble missing information on reference frames and stable conformational sub-states. To this end, we model a protein ensemble as a mixture of Gaussian probability distributions of either entire conformations or structural segments. We learn these models from a protein ensemble using the expectation-maximization algorithm. Our first model can be used to find multiple conformers in a structure ensemble. The second model partitions the protein chain into locally stable structural segments or core elements and less structured regions typically found in loops. Both models are simple to implement and contain only a single free parameter: the number of conformers or structural segments. Our models can be used to analyse experimental ensembles, molecular dynamics trajectories and conformational change in proteins. The Python source code for protein ensemble analysis is available from the authors upon request.

Assessing a Norwegian translation of the Organizational Climate Measure.

PubMed

Bernstrøm, Vilde Hoff; Lone, Jon Anders; Bjørkli, Cato A; Ulleberg, Pål; Hoff, Thomas

2013-04-01

This study investigated the Norwegian translation of the Organizational Climate Measure developed by Patterson and colleagues. The Organizational Climate Measure is a global measure of organizational climate based on Quinn and Rohrbaugh's competing values model. The survey was administered to a Norwegian branch of an international service sector company (N = 555). The results revealed satisfactory internal reliability and interrater agreement for the 17 scales, and confirmatory factor analysis supported the original factor structure. The findings gave preliminary support for the Organizational Climate Measure as a reliable measure with a stable factor structure, and indicated that it is potentially useful in the Norwegian context.

USM3D Predictions of Supersonic Nozzle Flow

NASA Technical Reports Server (NTRS)

Carter, Melissa B.; Elmiligui, Alaa A.; Campbell, Richard L.; Nayani, Sudheer N.

2014-01-01

This study focused on the NASA Tetrahedral Unstructured Software System CFD code (USM3D) capability to predict supersonic plume flow. Previous studies, published in 2004 and 2009, investigated USM3D's results versus historical experimental data. This current study continued that comparison however focusing on the use of the volume souring to capture the shear layers and internal shock structure of the plume. This study was conducted using two benchmark axisymmetric supersonic jet experimental data sets. The study showed that with the use of volume sourcing, USM3D was able to capture and model a jet plume's shear layer and internal shock structure.

Internal Structure of Charged Particles in a GRT Gravitational Model

NASA Astrophysics Data System (ADS)

Khlestkov, Yu. A.; Sukhanova, L. A.

2018-05-01

With the help of an exact solution of the Einstein and Maxwell equations, the internal structure of a multiply connected space of wormhole type with two unclosed static throats leading out of it into two parallel vacuum spaces or into one space is investigated in GRT for a free electric field and dust-like matter. The given geometry is considered as a particle-antiparticle pair with fundamental constants arising in the form of first integrals in the solution of the Cauchy problem - electric charges ±e of opposite sign in the throats and rest mass m0 - the total gravitational mass of the inner world of the particle in the throat. With the help of the energy conservation law, the unremovable rotation of the internal structure is included and the projection of the angular momentum of which onto the rotation axis is identified with the z-projection of the spin of the charged particle. The radius of 2-Gaussian curvature of the throat R* is identified with the charge radius of the particle, and the z-projection of the magnetic moment and the g-factor are found. The feasibility of the given gravitational model is confirmed by the found condition of independence of the spin quantum number of the electron and the proton s = 1/2 of the charge radius R* and the relativistic rest mass m* of the rotating throat, which is reliably confirmed experimentally, and also by the coincidence with high accuracy of the proton radius calculated in the model R*p = 0.8412·10-13 cm with the value of the proton charge radius obtained experimentally by measuring the Lamb shift on muonic hydrogen. The electron in the given model also turns out to be a structured particle with radius R*e = 3.8617·10-11 cm.

Adaptive Modeling, Engineering Analysis and Design of Advanced Aerospace Vehicles

NASA Technical Reports Server (NTRS)

Mukhopadhyay, Vivek; Hsu, Su-Yuen; Mason, Brian H.; Hicks, Mike D.; Jones, William T.; Sleight, David W.; Chun, Julio; Spangler, Jan L.; Kamhawi, Hilmi; Dahl, Jorgen L.

2006-01-01

This paper describes initial progress towards the development and enhancement of a set of software tools for rapid adaptive modeling, and conceptual design of advanced aerospace vehicle concepts. With demanding structural and aerodynamic performance requirements, these high fidelity geometry based modeling tools are essential for rapid and accurate engineering analysis at the early concept development stage. This adaptive modeling tool was used for generating vehicle parametric geometry, outer mold line and detailed internal structural layout of wing, fuselage, skin, spars, ribs, control surfaces, frames, bulkheads, floors, etc., that facilitated rapid finite element analysis, sizing study and weight optimization. The high quality outer mold line enabled rapid aerodynamic analysis in order to provide reliable design data at critical flight conditions. Example application for structural design of a conventional aircraft and a high altitude long endurance vehicle configuration are presented. This work was performed under the Conceptual Design Shop sub-project within the Efficient Aerodynamic Shape and Integration project, under the former Vehicle Systems Program. The project objective was to design and assess unconventional atmospheric vehicle concepts efficiently and confidently. The implementation may also dramatically facilitate physics-based systems analysis for the NASA Fundamental Aeronautics Mission. In addition to providing technology for design and development of unconventional aircraft, the techniques for generation of accurate geometry and internal sub-structure and the automated interface with the high fidelity analysis codes could also be applied towards the design of vehicles for the NASA Exploration and Space Science Mission projects.

Evolutionary transition from biological to social systems via generation of reflexive models of externality.

PubMed

Igamberdiev, Abir U

2017-12-01

Evolutionary transition from biological to social systems corresponds to the emergence of the structure of subject that incorporates the internal image of the external world. This structure, established on the basis of referral of the subject (self) to its symbolic image, acquires a potential to rationally describe the external world through the semiotic structure of human language. It has been modelled in reflexive psychology using the algebra of simple relations (Lefebvre, V.A., J. Soc. Biol. Struct. 10, 129-175, 1987). The model introduces a substantial opposition of the two basic complementary types of reflexion defined as Western (W) and Eastern (E). These types generate opposite models of behavior and opposite organizations of societies. Development of human societies involves the interactions of W and E types not only between the societies but also within one society underlying its homeostasis and dynamics. Invention of new ideas and implementation of new technologies shift the probability pattern of reflexive choices, appearing as internal assessments of the individual agents within a society, and direct changes in the preference of reflexive types. The dynamics of societies and of interactions between societies is based on the interference of opposite reflexive structures and on the establishment of different patterns during such interference. At different times in the history of human civilization these changing patterns resulted in the formation and splitting of large empires, the development and spreading of new technologies, the consecutive periods of wellness and decline. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Fragment-Cloud Model for Breakup of Asteroids with Varied Internal Structures

NASA Technical Reports Server (NTRS)

Wheeler, Lorien; Mathias, Donovan; Stokan, Ed; Brown, Peter

2016-01-01

As an asteroid descends toward Earth, it deposits energy in the atmosphere through aerodynamic drag and ablation. Asteroid impact risk assessments rely on energy deposition estimates to predict blast overpressures and ground damage that may result from an airburst, such as the one that occurred over Chelyabinsk, Russia in 2013. The rates and altitudes at which energy is deposited along the entry trajectory depend upon how the bolide fragments, which in turn depends upon its internal structure and composition. In this work, we have developed an analytic asteroid fragmentation model to assess the atmospheric energy deposition of asteroids with a range of structures and compositions. The modeling approach combines successive fragmentation of larger independent pieces with aggregate debris clouds released with each fragmentation event. The model can vary the number and masses of fragments produced, the amount of mass released as debris clouds, the size-strength scaling used to increase the robustness of smaller fragments, and other parameters. The initial asteroid body can be seeded with a distribution of independent fragment sizes amid a remaining debris mass to represent loose rubble pile conglomerations, can be given an outer regolith later, or can be defined as a coherent or fractured monolith. This approach enables the model to represent a range of breakup behaviors and reproduce detailed energy deposition features such as multiple flares due to successive burst events, high-altitude regolith blow-off, or initial disruption of rubble piles followed by more energetic breakup of the constituent boulders. These capabilities provide a means to investigate sensitivities of ground damage to potential variations in asteroid structure.

Plate Deformation Behavior of Polymer Matrix Composite-Ti Honeycomb-Metal Sandwiches for Pressurized Propulsion Component Applications

NASA Technical Reports Server (NTRS)

Bertelsen, William D.; Shin, E. eugene; Thesken, John C.; Sutter, James K.; Martin, Rich

2004-01-01

THe objectives are: 1. To experimentally validate bi-axial plate flexural performance of PMC-Ti H/C-A286 sandwich panels for the internally pressurized RBCC combustion chamber support structure. 2. To explore ASTM 2-D plate flexure test (D 6416) to simulate the internal pressure loading and to correlate the results with analytical and FE modeling based on 2-D flexure properties.

The Effect of Espoused National Cultural Values, the Five-Factor Model of Personality, and the Context of Travel on Technology Acceptance across Two Levels of Structured Tourism Websites

ERIC Educational Resources Information Center

Welsh, Laura

2011-01-01

According to the World Tourism Organization, there were 935 million international tourists in 2010. International tourists collectively spent $852 billion on tourism products in 2009 (World Tourism Organization, 2011). A tourist's awareness, selection, and choice of tourism products are extremely dependent on the information used by the tourist…

Microgravity

NASA Image and Video Library

1999-12-01

Dr. Donald Gilles, the Discipline Scientist for Materials Science in NASA's Microgravity Materials Science and Applications Department, demonstrates to Carl Dohrman a model of dendrites, the branch-like structures found in many metals and alloys. Dohrman was recently selected by the American Society for Metals International as their 1999 ASM International Foundation National Merit Scholar. The University of Illinois at Urbana-Champaign freshman recently toured NASA's materials science facilities at the Marshall Space Flight Center.

Self-Determination and Meaningful Work: Exploring Socioeconomic Constraints.

PubMed

Allan, Blake A; Autin, Kelsey L; Duffy, Ryan D

2016-01-01

This study examined a model of meaningful work among a diverse sample of working adults. From the perspectives of Self-Determination Theory and the Psychology of Working Framework, we tested a structural model with social class and work volition predicting SDT motivation variables, which in turn predicted meaningful work. Partially supporting hypotheses, work volition was positively related to internal regulation and negatively related to amotivation, whereas social class was positively related to external regulation and amotivation. In turn, internal regulation was positively related to meaningful work, whereas external regulation and amotivation were negatively related to meaningful work. Indirect effects from work volition to meaningful work via internal regulation and amotivation were significant, and indirect effects from social class to meaningful work via external regulation and amotivation were significant. This study highlights the important relations between SDT motivation variables and meaningful work, especially the large positive relation between internal regulation and meaningful work. However, results also reveal that work volition and social class may play critical roles in predicting internal regulation, external regulation, and amotivation.

Exploring the Internal Dynamics of Globular Clusters

NASA Astrophysics Data System (ADS)

Watkins, Laura L.; van der Marel, Roeland; Bellini, Andrea; Luetzgendorf, Nora; HSTPROMO Collaboration

2018-01-01

Exploring the Internal Dynamics of Globular ClustersThe formation histories and structural properties of globular clusters are imprinted on their internal dynamics. Energy equipartition results in velocity differences for stars of different mass, and leads to mass segregation, which results in different spatial distributions for stars of different mass. Intermediate-mass black holes significantly increase the velocity dispersions at the centres of clusters. By combining accurate measurements of their internal kinematics with state-of-the-art dynamical models, we can characterise both the velocity dispersion and mass profiles of clusters, tease apart the different effects, and understand how clusters may have formed and evolved.Using proper motions from the Hubble Space Telescope Proper Motion (HSTPROMO) Collaboration for a set of 22 Milky Way globular clusters, and our discrete dynamical modelling techniques designed to work with large, high-quality datasets, we are studying a variety of internal cluster properties. We will present the results of theoretical work on simulated clusters that demonstrates the efficacy of our approach, and preliminary results from application to real clusters.

A New Algorithm for Identifying Cis-Regulatory Modules Based on Hidden Markov Model

PubMed Central

2017-01-01

The discovery of cis-regulatory modules (CRMs) is the key to understanding mechanisms of transcription regulation. Since CRMs have specific regulatory structures that are the basis for the regulation of gene expression, how to model the regulatory structure of CRMs has a considerable impact on the performance of CRM identification. The paper proposes a CRM discovery algorithm called ComSPS. ComSPS builds a regulatory structure model of CRMs based on HMM by exploring the rules of CRM transcriptional grammar that governs the internal motif site arrangement of CRMs. We test ComSPS on three benchmark datasets and compare it with five existing methods. Experimental results show that ComSPS performs better than them. PMID:28497059

Modeling of structure and properties of thermo-optical converters for laser surgery

NASA Astrophysics Data System (ADS)

Belikov, Andrey V.; Skrypnik, Alexei V.; Kurnyshev, Vadim Y.

2016-04-01

Volumetric fiber-optic thermal converter (VFOTC) formed on the end of the quartz fiber as a result of two-stage conversion of quartz and carbon by medical diode laser radiation with a wavelength of 980 nm is investigated both experimentally and theoretically. The geometrical dimensions of the converter are defined and the internal structure of the converter is studied by optical microscopy. The dependence of VFOTC temperature on exposure time of diode laser radiation with a wavelength of 980 nm and power of 1.0+/-0.1 W is obtained experimentally. The structural, optical and thermal model of VFOTC is proposed. Good correlation between the experimental and modeling results of laser heating of the converter is demonstrated.

Understand rotating isothermal collapses yet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tohline, J.E.

1985-01-01

A scalar virial equation is used to describe the dynamic properties of equilibrium gas clouds, taking into account the relative effects of surface pressure, rotation, self gravity and internal isothermal pressure. Details concerning the internal structure of the clouds are ignored in order to obtain a globalized analytical expression. The obtained solution to the equation is found to agree with the surface-pressure-dominated model of Stahler (1983), and the rotation-dominated model of Hayashi, Narita, and Miyama (1982). On the basis of the analytical expression of virial equilibrium in the clouds, some of the limiting properties of isothermal clouds are described, andmore » a realistic starting model for cloud collapse is proposed. 18 references.« less

From affliction to affirmation: narrative transformation and the therapeutics of Candomblé mediumship.

PubMed

Seligman, Rebecca

2005-06-01

Through the presentation and analysis of a prototypical mediumship narrative, this article shows how individuals initiated into the Candomblé religion of north-eastern Brazil come to alter their own self-narratives by learning and internalizing the cultural model for an established social/religious role: that of the medium. As individuals come to identify with this 'role model,' they are able to reinterpret their own life histories in terms of the model's structure and its symbolic content. This article also demonstrates how the social articulation and cognitive internalization of this new self-narrative act therapeutically, to foster a positive transformation in self-understanding that facilitates positive behavior.

Model reduction in a subset of the original states

NASA Technical Reports Server (NTRS)

Yae, K. H.; Inman, D. J.

1992-01-01

A model reduction method is investigated to provide a smaller structural dynamic model for subsequent structural control design. A structural dynamic model is assumed to be derived from finite element analysis. It is first converted into the state space form, and is further reduced by the internal balancing method. Through the co-ordinate transformation derived from the states that are deleted during reduction, the reduced model is finally expressed with the states that are members of the original states. Therefore, the states in the final reduced model represent the degrees of freedom of the nodes that are selected by the designer. The procedure provides a more practical implementation of model reduction for applications in which specific nodes, such as sensor and/or actuator attachment points, are to be retained in the reduced model. Thus, it ensures that the reduced model is under the same input and output condition as the original physical model. The procedure is applied to two simple examples and comparisons are made between the full and reduced order models. The method can be applied to a linear, continuous and time-invariant model of structural dynamics with nonproportional viscous damping.

A Model of Female Sexual Desire: Internalized Working Models of Parent-Child Relationships and Sexual Body Self-Representations.

PubMed

Cherkasskaya, Eugenia; Rosario, Margaret

2017-11-01

The etiology of low female sexual desire, the most prevalent sexual complaint in women, is multi-determined, implicating biological and psychological factors, including women's early parent-child relationships and bodily self-representations. The current study evaluated a model that hypothesized that sexual body self-representations (sexual subjectivity, self-objectification, genital self-image) explain (i.e., mediate) the relation between internalized working models of parent-child relationships (attachment, separation-individuation, parental identification) and sexual desire in heterosexual women. We recruited 614 young, heterosexual women (M = 25.5 years, SD = 4.63) through social media. The women completed an online survey. Structural equation modeling was used. The hypotheses were supported in that the relation between internalized working models of parent-child relationships (attachment and separation-individuation) and sexual desire was mediated by sexual body self-representations (sexual body esteem, self-objectification, genital self-image). However, parental identification was not related significantly to sexual body self-representations or sexual desire in the model. Current findings demonstrated that understanding female sexual desire necessitates considering women's internalized working models of early parent-child relationships and their experiences of their bodies in a sexual context. Treatment of low or absent desire in women would benefit from modalities that emphasize early parent-child relationships as well as interventions that foster mind-body integration.

Outsourcing versus in-house maintenance of medical devices: a longitudinal, empirical study.

PubMed

Miguel-Cruz, Antonio; Rios-Rincón, Adriana; Haugan, Gregory L

2014-03-01

To determine what factors have a significant influence on the performance of medical device maintenance outsourcing, and to determine how the performance of external governance structures differs depending on whether a hospital is private or public. This was a longitudinal study of 590 maintenance transactions at 20 hospitals in Bogotá, Colombia, involving 764 medical devices and 72 maintenance service providers. Maintenance performance data (i.e., turn-around time in hours; TAT) for the service providers (either in-house or outsourced) were primarily collected over a 20-month period, from December 2009-August 2011, by means of a monitoring procedure; then, a hazards model was run. The availability of specific repair parts, in-stock, in the city in which the medical devices were located, had a positive impact on the performance of both internal and external governance structures. Online service also had a positive impact on both, with a stronger positive impact on the performance of internal governance than on that of external governance. For transactions governed by external structures, better performance was seen in private hospitals than in public ones. In public health institutions, internal governance showed better performance than external governance. Both internal and external governance structures showed better performance in private healthcare institutions than in public ones. In public health institutions, internal governance shows better performance than external governance; this suggests that healthcare managers should reconsider the trend to eliminate in-house maintenance service staff in public healthcare institutions.

[Master trainer concept "structured specialist further education" : A joint project of the German Professional Associations of Internal Medicine, Surgeons and Orthopedic/Trauma Surgeons].

PubMed

Siebolds, M; Ansorg, J; Dittmar, R; Hennes, N; Radau, T; Ruff, S; Denkinger, M D

2017-10-01

The quality requirements in the practice of postgradual medical further education below the normal level of the further education regulations is a barely developed scientific field in Germany. A systematic use of internationally accepted scientific evidence barely exists. This research and development project was initiated in 2001 in order to be able to implement a practical but evidence-based model compatible with the existing structure of postgradual medical education. This project has been supported since 2013 by the Professional Associations of Internal Medicine (BDI), Surgeons (BDC) and Orthopedic and Trauma surgeons (BVOU). The development phase of this complex intervention was based on three stages involving stakeholder interviews from relevant groups, the identification of a theoretical model for the construction and systematic literature reviews to identify the relevant evidence. The basic model for structured specialist further education developed included the creation and implementation of a simple core curriculum for every department, a tool for systematic feedback within the framework of the annual further education interviews and a simple clinical assessment to evaluate the actual clinical performance of physicians in further education. A pilot test of this model was carried out in 150 specialist departments in Germany and continually developed. The project shows that such a program can be systematically developed and pilot studies can be carried out. The central problems in implementation involve the traditional informal further education culture, which as a rule does not implement a systematic elicitation of the state of learning continuously distributed over the whole period of further education and the practical testing of competence development.

Static shape control for adaptive wings

NASA Astrophysics Data System (ADS)

Austin, Fred; Rossi, Michael J.; van Nostrand, William; Knowles, Gareth; Jameson, Antony

1994-09-01

A theoretical method was developed and experimentally validated, to control the static shape of flexible structures by employing internal translational actuators. A finite element model of the structure, without the actuators present, is employed to obtain the multiple-input, multiple-output control-system gain matrices for actuator-load control as well as actuator-displacement control. The method is applied to the quasistatic problem of maintaining an optimum-wing cross section during various transonic-cruise flight conditions to obtain significant reductions in the shock-induced drag. Only small, potentially achievable, adaptive modifications to the profile are required. The adaptive-wing concept employs actuators as truss elements of active ribs to reshape the wing cross section by deforming the structure. Finite element analyses of an adaptive-rib model verify the controlled-structure theory. Experiments on the model were conducted, and arbitrarily selected deformed shapes were accurately achieved.

Evaluation of the Thermodynamic Consistency of Closure Approximations in Several Models Proposed for the Description of Liquid Crystalline Dynamics

NASA Astrophysics Data System (ADS)

Edwards, Brian J.

2002-05-01

Given the premise that a set of dynamical equations must possess a definite, underlying mathematical structure to ensure local and global thermodynamic stability, as has been well documented, several different models for describing liquid crystalline dynamics are examined with respect to said structure. These models, each derived during the past several years using a specific closure approximation for the fourth moment of the distribution function in Doi's rigid rod theory, are all shown to be inconsistent with this basic mathematical structure. The source of this inconsistency lies in Doi's expressions for the extra stress tensor and temporal evolution of the order parameter, which are rederived herein using a transformation that allows for internal compatibility with the underlying mathematical structure that is present on the distribution function level of description.

An expert system for the selection of building elements during architectural design

NASA Astrophysics Data System (ADS)

Alibaba, Halil Zafer

This thesis explains the development stages of an expert system for the evaluation and selection of building elements during the early stages of architectural design. This expert system is called BES. It is produced after two prototypes were established. Testing of BES is made on professional architects who are from both academia and the practical construction market of Northern Cyprus. BES is intended to be used by experienced and inexperienced architects. The model includes selection of all kinds of main building elements that are available like retaining walls, foundations, external walls, internal walls, floors, external stairs, internal stairs, roofs, external chimneys, internal chimneys, windows and external doors and internal doors and their sub-type building elements. The selection is achieved via SMART Methodology depending on the performance requirements and an expert system shell Exsys Corvid version 1.2.14 is used to structure the expert system. The use of computers in today's world is very important with its advantages in handling vast amount of data. The use of the model through Internet makes the model international, and a useful design aid for architects. In addition, the decision-making feature of this model provides a suitable selection among numerous alternatives. The thesis also explains the development and the experience gained through use of the BES. It discusses the further development of the model.

Quantum mechanics/molecular mechanics structural models of the oxygen-evolving complex of photosystem II.

PubMed

Sproviero, Eduardo M; Gascón, José A; McEvoy, James P; Brudvig, Gary W; Batista, Victor S

2007-04-01

The annual production of 260 Gtonnes of oxygen, during the process of photosynthesis, sustains life on earth. Oxygen is produced in the thylakoid membranes of green-plant chloroplasts and the internal membranes of cyanobacteria by photocatalytic water oxidation at the oxygen-evolving complex (OEC) of photosystem II (PSII). Recent breakthroughs in X-ray crystallography and advances in quantum mechanics/molecular mechanics (QM/MM) hybrid methods have enabled the construction of chemically sensible models of the OEC of PSII. The resulting computational structural models suggest the complete ligation of the catalytic center by amino acid residues, water, hydroxide and chloride, as determined from the intrinsic electronic properties of the oxomanganese core and the perturbational influence of the surrounding protein environment. These structures are found to be consistent with available mechanistic data, and are also compatible with X-ray diffraction models and extended X-ray absorption fine structure measurements. It is therefore conjectured that these OEC models are particularly relevant for the elucidation of the catalytic mechanism of water oxidation.

Calibrating White Dwarf Asteroseismic Fitting Techniques

NASA Astrophysics Data System (ADS)

Castanheira, B. G.; Romero, A. D.; Bischoff-Kim, A.

2017-03-01

The main goal of looking for intrinsic variability in stars is the unique opportunity to study their internal structure. Once we have extracted independent modes from the data, it appears to be a simple matter of comparing the period spectrum with those from theoretical model grids to learn the inner structure of that star. However, asteroseismology is much more complicated than this simple description. We must account not only for observational uncertainties in period determination, but most importantly for the limitations of the model grids, coming from the uncertainties in the constitutive physics, and of the fitting techniques. In this work, we will discuss results of numerical experiments where we used different independently calculated model grids (white dwarf cooling models WDEC and fully evolutionary LPCODE-PUL) and fitting techniques to fit synthetic stars. The advantage of using synthetic stars is that we know the details of their interior structure so we can assess how well our models and fitting techniques are able to the recover the interior structure, as well as the stellar parameters.

ENSO-related Interannual Variability of Southern Hemisphere Atmospheric Circulation: Assessment and Projected Changes in CMIP5 Models

NASA Astrophysics Data System (ADS)

Frederiksen, Carsten; Grainger, Simon; Zheng, Xiaogu; Sisson, Janice

2013-04-01

ENSO variability is an important driver of the Southern Hemisphere (SH) atmospheric circulation. Understanding the observed and projected changes in ENSO variability is therefore important to understanding changes in Australian surface climate. Using a recently developed methodology (Zheng et al., 2009), the coherent patterns, or modes, of ENSO-related variability in the SH atmospheric circulation can be separated from modes that are related to intraseasonal variability or to changes in radiative forcings. Under this methodology, the seasonal mean SH 500 hPa geopotential height is considered to consist of three components. These are: (1) an intraseasonal component related to internal dynamics on intraseasonal time scales; (2) a slow-internal component related to internal dynamics on slowly varying (interannual or longer) time scales, including ENSO; and (3) a slow-external component related to external (i.e. radiative) forcings. Empirical Orthogonal Functions (EOFs) are used to represent the modes of variability of the interannual covariance of the three components. An assessment is first made of the modes in models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) dataset for the SH summer and winter seasons in the 20th century. In reanalysis data, two EOFs of the slow component (which includes the slow-internal and slow-external components) have been found to be related to ENSO variability (Frederiksen and Zheng, 2007). In SH summer, the CMIP5 models reproduce the leading ENSO mode very well when the structures of the EOF and the associated SST, and associated variance are considered. There is substantial improvement in this mode when compared with the CMIP3 models shown in Grainger et al. (2012). However, the second ENSO mode in SH summer has a poorly reproduced EOF structure in the CMIP5 models, and the associated variance is generally underestimated. In SH winter, the performance of the CMIP5 models in reproducing the structure and variance is similar for both ENSO modes, with the associated variance being generally underestimated. Projected changes in the modes in the 21st century are then investigated using ensembles of CMIP5 models that reproduce well the 20th century slow modes. The slow-internal and slow-external components are examined separately, allowing the projected changes in the response to ENSO variability to be separated from the response to changes in greenhouse gas concentrations. By using several ensembles, the model-dependency of the projected changes in the ENSO-related slow-internal modes is examined. Frederiksen, C. S., and X. Zheng, 2007: Variability of seasonal-mean fields arising from intraseasonal variability. Part 3: Application to SH winter and summer circulations. Climate Dyn., 28, 849-866. Grainger, S., C. S. Frederiksen, and X. Zheng, 2012: Modes of interannual variability of Southern Hemisphere atmospheric circulation in CMIP3 models: Assessment and Projections. Climate Dyn., in press. Zheng, X., D. M. Straus, C. S. Frederiksen, and S. Grainger, 2009: Potentially predictable patterns of extratropical tropospheric circulation in an ensemble of climate simulations with the COLA AGCM. Quart. J. Roy. Meteor. Soc., 135, 1816-1829.

Geostatistical three-dimensional modeling of oolite shoals, St. Louis Limestone, southwest Kansas

USGS Publications Warehouse

Qi, L.; Carr, T.R.; Goldstein, R.H.

2007-01-01

In the Hugoton embayment of southwestern Kansas, reservoirs composed of relatively thin (<4 m; <13.1 ft) oolitic deposits within the St. Louis Limestone have produced more than 300 million bbl of oil. The geometry and distribution of oolitic deposits control the heterogeneity of the reservoirs, resulting in exploration challenges and relatively low recovery. Geostatistical three-dimensional (3-D) models were constructed to quantify the geometry and spatial distribution of oolitic reservoirs, and the continuity of flow units within Big Bow and Sand Arroyo Creek fields. Lithofacies in uncored wells were predicted from digital logs using a neural network. The tilting effect from the Laramide orogeny was removed to construct restored structural surfaces at the time of deposition. Well data and structural maps were integrated to build 3-D models of oolitic reservoirs using stochastic simulations with geometry data. Three-dimensional models provide insights into the distribution, the external and internal geometry of oolitic deposits, and the sedimentologic processes that generated reservoir intervals. The structural highs and general structural trend had a significant impact on the distribution and orientation of the oolitic complexes. The depositional pattern and connectivity analysis suggest an overall aggradation of shallow-marine deposits during pulses of relative sea level rise followed by deepening near the top of the St. Louis Limestone. Cemented oolitic deposits were modeled as barriers and baffles and tend to concentrate at the edge of oolitic complexes. Spatial distribution of porous oolitic deposits controls the internal geometry of rock properties. Integrated geostatistical modeling methods can be applicable to other complex carbonate or siliciclastic reservoirs in shallow-marine settings. Copyright ?? 2007. The American Association of Petroleum Geologists. All rights reserved.

Validation of the Spanish version of the Drive for Muscularity Scale (DMS) among males: Confirmatory factor analysis.

PubMed

Sepulveda, Ana R; Parks, Melissa; de Pellegrin, Yolanda; Anastasiadou, Dimitra; Blanco, Miriam

2016-04-01

Drive for Muscularity (DM) has been shown to be a relevant construct for measuring and understanding male body image. For this reason, it is important to have reliable and valid instruments with which to measure DM, and to date no such instruments exist in Spain. This study analyzes the psychometric and structural properties of the Drive for Muscularity Scale (DMS) in a sample of Spanish adolescent males (N=212), with the aim of studying the structural validity of the scale by using a confirmatory factor analysis (CFA), as well as analyzing the internal consistency and construct (convergent and discriminant) and concurrent validity of the instrument. After testing three models, results indicated that the best structure was a two-dimensional model, with the factors of muscularity-oriented body image (MBI) and muscularity behavior (MB). The scale showed good internal consistency (α=.90) and adequate construct validity. Furthermore, significant associations were found between DM and increased difficulties in emotional regulation (rho=.37) and low self-esteem (rho=-.19). Findings suggest that the two-factor structure may be used when assessing drive for muscularity among adolescent males in Spain. Copyright © 2016 Elsevier Ltd. All rights reserved.

Direct Bio-printing with Heterogeneous Topology Design.

PubMed

Ahsan, Amm Nazmul; Xie, Ruinan; Khoda, Bashir

2017-01-01

Bio-additive manufacturing is a promising tool to fabricate porous scaffold structures for expediting the tissue regeneration processes. Unlike the most traditional bulk material objects, the microstructures of tissue and organs are mostly highly anisotropic, heterogeneous, and porous in nature. However, modelling the internal heterogeneity of tissues/organs structures in the traditional CAD environment is difficult and oftentimes inaccurate. Besides, the de facto STL conversion of bio-models introduces loss of information and piles up more errors in each subsequent step (build orientation, slicing, tool-path planning) of the bio-printing process plan. We are proposing a topology based scaffold design methodology to accurately represent the heterogeneous internal architecture of tissues/organs. An image analysis technique is used that digitizes the topology information contained in medical images of tissues/organs. A weighted topology reconstruction algorithm is implemented to represent the heterogeneity with parametric functions. The parametric functions are then used to map the spatial material distribution. The generated information is directly transferred to the 3D bio-printer and heterogeneous porous tissue scaffold structure is manufactured without STL file. The proposed methodology is implemented to verify the effectiveness of the approach and the designed example structure is bio-fabricated with a deposition based bio-additive manufacturing system.

Beam Flutter and Energy Harvesting in Internal Flow

NASA Astrophysics Data System (ADS)

Tosi, Luis Phillipe; Colonius, Tim; Sherrit, Stewart; Lee, Hyeong Jae

2017-11-01

Aeroelastic flutter, largely studied for causing engineering failures, has more recently been used as a means of extracting energy from the flow. Particularly, flutter of a cantilever or an elastically mounted plate in a converging-diverging flow passage has shown promise as an energy harvesting concept for internal flow applications. The instability onset is observed as a function of throat velocity, internal wall geometry, fluid and structure material properties. To enable these devices, our work explores features of the fluid-structure coupled dynamics as a function of relevant nondimensional parameters. The flutter boundary is examined through stability analysis of a reduced order model, and corroborated with numerical simulations at low Reynolds number. Experiments for an energy harvester design are qualitatively compared to results from analytical and numerical work, suggesting a robust limit cycle ensues due to a subcritical Hopf bifurcation. Bosch Corporation.

Live Imaging of Cellular Internalization of Single Colloidal Particle by Combined Label-Free and Fluorescence Total Internal Reflection Microscopy.

PubMed

Byrne, Gerard D; Vllasaliu, Driton; Falcone, Franco H; Somekh, Michael G; Stolnik, Snjezana

2015-11-02

In this work we utilize the combination of label-free total internal reflection microscopy and total internal reflectance fluorescence (TIRM/TIRF) microscopy to achieve a simultaneous, live imaging of single, label-free colloidal particle endocytosis by individual cells. The TIRM arm of the microscope enables label free imaging of the colloid and cell membrane features, while the TIRF arm images the dynamics of fluorescent-labeled clathrin (protein involved in endocytosis via clathrin pathway), expressed in transfected 3T3 fibroblasts cells. Using a model polymeric colloid and cells with a fluorescently tagged clathrin endocytosis pathway, we demonstrate that wide field TIRM/TIRF coimaging enables live visualization of the process of colloidal particle interaction with the labeled cell structure, which is valuable for discerning the membrane events and route of colloid internalization by the cell. We further show that 500 nm in diameter model polystyrene colloid associates with clathrin, prior to and during its cellular internalization. This association is not apparent with larger, 1 μm in diameter colloids, indicating an upper particle size limit for clathrin-mediated endocytosis.

Mobile Communication Via Satellite

NASA Technical Reports Server (NTRS)

Yan, Tsun-Yee; Naderi, Firouz M.

1988-01-01

System mixes real-time and delayed-transmission channels. Combination of L-band and SHF links connect fixed and mobile equipment on ground to satellite relay. Software and hardware architecture conforms structure of open-system-interconnection model suggested by International Standards Organization.

Internal marketing and the antecedents of nurse satisfaction and loyalty.

PubMed

Peltier, James W; Pointer, Lucille; Schibrowsky, John A

2008-01-01

Employee satisfaction and retention are critical issues that influence the success of any organization. Yet, one of the most critical problems facing the worldwide health care industry is the shortage of qualified nurses. Recent calls have been made within the traditional nursing literature for research that utilizes marketing and business models to better understand nurse satisfaction and retention. The purpose of this study is to develop scales that can be used to empirically test a model of the proposed antecedents of nurse job satisfaction and loyalty which have been used widely in the internal marketing and the relationship-marketing literature. Specifically, the study will investigate the degree to which structural bonding, social bonding, financial bonding activities, and quality of care impact how well nurses are satisfied with their job and their commitment to the organization. The results show that quality of care most impacted nurse satisfaction and loyalty, followed by structural, social, and financial bonds.

Criteria for robustness of heteroclinic cycles in neural microcircuits

PubMed Central

2011-01-01

We introduce a test for robustness of heteroclinic cycles that appear in neural microcircuits modeled as coupled dynamical cells. Robust heteroclinic cycles (RHCs) can appear as robust attractors in Lotka-Volterra-type winnerless competition (WLC) models as well as in more general coupled and/or symmetric systems. It has been previously suggested that RHCs may be relevant to a range of neural activities, from encoding and binding to spatio-temporal sequence generation. The robustness or otherwise of such cycles depends both on the coupling structure and the internal structure of the neurons. We verify that robust heteroclinic cycles can appear in systems of three identical cells, but only if we require perturbations to preserve some invariant subspaces for the individual cells. On the other hand, heteroclinic attractors can appear robustly in systems of four or more identical cells for some symmetric coupling patterns, without restriction on the internal dynamics of the cells. PMID:22656192

Observation of three-dimensional internal structure of steel materials by means of serial sectioning with ultrasonic elliptical vibration cutting.

PubMed

Fujisaki, K; Yokota, H; Nakatsuchi, H; Yamagata, Y; Nishikawa, T; Udagawa, T; Makinouchi, A

2010-01-01

A three-dimensional (3D) internal structure observation system based on serial sectioning was developed from an ultrasonic elliptical vibration cutting device and an optical microscope combined with a high-precision positioning device. For bearing steel samples, the cutting device created mirrored surfaces suitable for optical metallography, even for long-cutting distances during serial sectioning of these ferrous materials. Serial sectioning progressed automatically by means of numerical control. The system was used to observe inclusions in steel materials on a scale of several tens of micrometers. Three specimens containing inclusions were prepared from bearing steels. These inclusions could be detected as two-dimensional (2D) sectional images with resolution better than 1 mum. A three-dimensional (3D) model of each inclusion was reconstructed from the 2D serial images. The microscopic 3D models had sharp edges and complicated surfaces.

Software life cycle dynamic simulation model: The organizational performance submodel

NASA Technical Reports Server (NTRS)

Tausworthe, Robert C.

1985-01-01

The submodel structure of a software life cycle dynamic simulation model is described. The software process is divided into seven phases, each with product, staff, and funding flows. The model is subdivided into an organizational response submodel, a management submodel, a management influence interface, and a model analyst interface. The concentration here is on the organizational response model, which simulates the performance characteristics of a software development subject to external and internal influences. These influences emanate from two sources: the model analyst interface, which configures the model to simulate the response of an implementing organization subject to its own internal influences, and the management submodel that exerts external dynamic control over the production process. A complete characterization is given of the organizational response submodel in the form of parameterized differential equations governing product, staffing, and funding levels. The parameter values and functions are allocated to the two interfaces.

Integrating prior information into microwave tomography Part 1: Impact of detail on image quality.

PubMed

Kurrant, Douglas; Baran, Anastasia; LoVetri, Joe; Fear, Elise

2017-12-01

The authors investigate the impact that incremental increases in the level of detail of patient-specific prior information have on image quality and the convergence behavior of an inversion algorithm in the context of near-field microwave breast imaging. A methodology is presented that uses image quality measures to characterize the ability of the algorithm to reconstruct both internal structures and lesions embedded in fibroglandular tissue. The approach permits key aspects that impact the quality of reconstruction of these structures to be identified and quantified. This provides insight into opportunities to improve image reconstruction performance. Patient-specific information is acquired using radar-based methods that form a regional map of the breast. This map is then incorporated into a microwave tomography algorithm. Previous investigations have demonstrated the effectiveness of this approach to improve image quality when applied to data generated with two-dimensional (2D) numerical models. The present study extends this work by generating prior information that is customized to vary the degree of structural detail to facilitate the investigation of the role of prior information in image formation. Numerical 2D breast models constructed from magnetic resonance (MR) scans, and reconstructions formed with a three-dimensional (3D) numerical breast model are used to assess if trends observed for the 2D results can be extended to 3D scenarios. For the blind reconstruction scenario (i.e., no prior information), the breast surface is not accurately identified and internal structures are not clearly resolved. A substantial improvement in image quality is achieved by incorporating the skin surface map and constraining the imaging domain to the breast. Internal features within the breast appear in the reconstructed image. However, it is challenging to discriminate between adipose and glandular regions and there are inaccuracies in both the structural properties of the glandular region and the dielectric properties reconstructed within this structure. Using a regional map with a skin layer only marginally improves this situation. Increasing the structural detail in the prior information to include internal features leads to reconstructions for which the interface that delineates the fat and gland regions can be inferred. Different features within the glandular region corresponding to tissues with varying relative permittivity values, such as a lesion embedded within glandular structure, emerge in the reconstructed images. Including knowledge of the breast surface and skin layer leads to a substantial improvement in image quality compared to the blind case, but the images have limited diagnostic utility for applications such as tumor response tracking. The diagnostic utility of the reconstruction technique is improved considerably when patient-specific structural information is used. This qualitative observation is supported quantitatively with image metrics. © 2017 American Association of Physicists in Medicine.

Quantitative structure-property relationship (QSPR) modeling of drug-loaded polymeric micelles via genetic function approximation.

PubMed

Wu, Wensheng; Zhang, Canyang; Lin, Wenjing; Chen, Quan; Guo, Xindong; Qian, Yu; Zhang, Lijuan

2015-01-01

Self-assembled nano-micelles of amphiphilic polymers represent a novel anticancer drug delivery system. However, their full clinical utilization remains challenging because the quantitative structure-property relationship (QSPR) between the polymer structure and the efficacy of micelles as a drug carrier is poorly understood. Here, we developed a series of QSPR models to account for the drug loading capacity of polymeric micelles using the genetic function approximation (GFA) algorithm. These models were further evaluated by internal and external validation and a Y-randomization test in terms of stability and generalization, yielding an optimization model that is applicable to an expanded materials regime. As confirmed by experimental data, the relationship between microstructure and drug loading capacity can be well-simulated, suggesting that our models are readily applicable to the quantitative evaluation of the drug-loading capacity of polymeric micelles. Our work may offer a pathway to the design of formulation experiments.

Quantitative Structure-Property Relationship (QSPR) Modeling of Drug-Loaded Polymeric Micelles via Genetic Function Approximation

PubMed Central

Lin, Wenjing; Chen, Quan; Guo, Xindong; Qian, Yu; Zhang, Lijuan

2015-01-01

Self-assembled nano-micelles of amphiphilic polymers represent a novel anticancer drug delivery system. However, their full clinical utilization remains challenging because the quantitative structure-property relationship (QSPR) between the polymer structure and the efficacy of micelles as a drug carrier is poorly understood. Here, we developed a series of QSPR models to account for the drug loading capacity of polymeric micelles using the genetic function approximation (GFA) algorithm. These models were further evaluated by internal and external validation and a Y-randomization test in terms of stability and generalization, yielding an optimization model that is applicable to an expanded materials regime. As confirmed by experimental data, the relationship between microstructure and drug loading capacity can be well-simulated, suggesting that our models are readily applicable to the quantitative evaluation of the drug-loading capacity of polymeric micelles. Our work may offer a pathway to the design of formulation experiments. PMID:25780923

Magnetic and thermodynamic properties of Ising model with borophene structure in a longitudinal magnetic field

NASA Astrophysics Data System (ADS)

Shi, Kaile; Jiang, Wei; Guo, Anbang; Wang, Kai; Wu, Chuang

2018-06-01

The magnetic and thermodynamic properties of borophene structure have been studied for the first time by Monte Carlo simulation. Two-dimensional borophene structure consisting of seven hexagonal B36 units is described by Ising model. Each B36 basic unit includes three benzene-like with spin-3/2. The general formula for the borophene structure is given. The numerical results of the magnetization, the magnetic susceptibility, the internal energy and the specific heat are studied with various parameters. The possibility to test the predicted magnetism in experiment are illustrated, for instance, the maximum on the magnetization curve. The multiple hysteresis loops and the magnetization plateaus are sensitive to the ferromagnetic or ferrimagnetic exchange coupling in borophene structure. The results show the borophene structure could have applications in spintronics, which deserves further studies in experiments.

Simulation Based Optimization of Complex Monolithic Composite Structures Using Cellular Core Technology

NASA Astrophysics Data System (ADS)

Hickmott, Curtis W.

Cellular core tooling is a new technology which has the capability to manufacture complex integrated monolithic composite structures. This novel tooling method utilizes thermoplastic cellular cores as inner tooling. The semi-rigid nature of the cellular cores makes them convenient for lay-up, and under autoclave temperature and pressure they soften and expand providing uniform compaction on all surfaces including internal features such as ribs and spar tubes. This process has the capability of developing fully optimized aerospace structures by reducing or eliminating assembly using fasteners or bonded joints. The technology is studied in the context of evaluating its capabilities, advantages, and limitations in developing high quality structures. The complex nature of these parts has led to development of a model using the Finite Element Analysis (FEA) software Abaqus and the plug-in COMPRO Common Component Architecture (CCA) provided by Convergent Manufacturing Technologies. This model utilizes a "virtual autoclave" technique to simulate temperature profiles, resin flow paths, and ultimately deformation from residual stress. A model has been developed simulating the temperature profile during curing of composite parts made with the cellular core technology. While modeling of composites has been performed in the past, this project will look to take this existing knowledge and apply it to this new manufacturing method capable of building more complex parts and develop a model designed specifically for building large, complex components with a high degree of accuracy. The model development has been carried out in conjunction with experimental validation. A double box beam structure was chosen for analysis to determine the effects of the technology on internal ribs and joints. Double box beams were manufactured and sectioned into T-joints for characterization. Mechanical behavior of T-joints was performed using the T-joint pull-off test and compared to traditional tooling methods. Components made with the cellular core tooling method showed an improved strength at the joints. It is expected that this knowledge will help optimize the processing of complex, integrated structures and benefit applications in aerospace where lighter, structurally efficient components would be advantageous.

Vibration assessment and structural monitoring of the Basilica of Maxentius in Rome

NASA Astrophysics Data System (ADS)

Pau, Annamaria; Vestroni, Fabrizio

2013-12-01

The present paper addresses the analysis of the ambient vibrations of the Basilica of Maxentius in Rome. This monument, in the city centre and close to busy roads, was the largest vaulted structure in the Roman Empire. Today, only one aisle of the structure remains, suffering from a complex crack scenario. The ambient vibration response is used to investigate traffic induced vibration and compare this to values that could be a potential cause of structural damage according to international standards. Using output-only methods, natural frequencies and mode shapes are obtained from the response, allowing comparison with predictions made with a finite element model. Notwithstanding simplifications regarding material behavior and crack pattern in the finite element model, an agreement between numerical and experimental results is reached once selected mechanical parameters are adjusted. A knowledge of modal characteristics and the availability of an updated model may be a first step of a structural monitoring program that could reveal any decay over time in the structural integrity of the monument.

Sound transmission through lightweight double-leaf partitions: theoretical modelling

NASA Astrophysics Data System (ADS)

Wang, J.; Lu, T. J.; Woodhouse, J.; Langley, R. S.; Evans, J.

2005-09-01

This paper presents theoretical modelling of the sound transmission loss through double-leaf lightweight partitions stiffened with periodically placed studs. First, by assuming that the effect of the studs can be replaced with elastic springs uniformly distributed between the sheathing panels, a simple smeared model is established. Second, periodic structure theory is used to develop a more accurate model taking account of the discrete placing of the studs. Both models treat incident sound waves in the horizontal plane only, for simplicity. The predictions of the two models are compared, to reveal the physical mechanisms determining sound transmission. The smeared model predicts relatively simple behaviour, in which the only conspicuous features are associated with coincidence effects with the two types of structural wave allowed by the partition model, and internal resonances of the air between the panels. In the periodic model, many more features are evident, associated with the structure of pass- and stop-bands for structural waves in the partition. The models are used to explain the effects of incidence angle and of the various system parameters. The predictions are compared with existing test data for steel plates with wooden stiffeners, and good agreement is obtained.

Conformable pressure vessel for high pressure gas storage

DOEpatents

Simmons, Kevin L.; Johnson, Kenneth I.; Lavender, Curt A.; Newhouse, Norman L.; Yeggy, Brian C.

2016-01-12

A non-cylindrical pressure vessel storage tank is disclosed. The storage tank includes an internal structure. The internal structure is coupled to at least one wall of the storage tank. The internal structure shapes and internally supports the storage tank. The pressure vessel storage tank has a conformability of about 0.8 to about 1.0. The internal structure can be, but is not limited to, a Schwarz-P structure, an egg-crate shaped structure, or carbon fiber ligament structure.

Technological Adoption and Organizational Adaptation: Developing a Model for Human Resource Management in an International Business Environment.

ERIC Educational Resources Information Center

Gattiker, Urs E.

A model of technological training has two dimensions: level of cultural stability and employee's level of cognitive ability. Each dimension has two variables. The variables of cultural stability are (1) technological adoption and organizational adaptation and (2) structure of work and work processes. For cognitive ability, the variables are…

A Covariance Structure Model Test of Antecedents of Adolescent Alcohol Misuse and a Prevention Effort.

ERIC Educational Resources Information Center

Dielman, T. E.; And Others

1989-01-01

Questionnaires were administered to 4,157 junior high school students to determine levels of alcohol misuse, exposure to peer use and misuse of alcohol, susceptibility to peer pressure, internal health locus of control, and self-esteem. Conceptual model of antecendents of adolescent alcohol misuse and effectiveness of a prevention effort was…

Cumulative Risk and Adolescent's Internalizing and Externalizing Problems: The Mediating Roles of Maternal Responsiveness and Self-Regulation

ERIC Educational Resources Information Center

Doan, Stacey N.; Fuller-Rowell, Thomas E.; Evans, Gary W.

2012-01-01

The purpose of the present study was to examine longitudinal associations among maternal responsiveness, self-regulation, and behavioral adjustment in adolescents. The authors used structural equation modeling to test a model that demonstrates that the effects of early cumulative risk on behavioral problems is mediated by maternal responsiveness…

Autonomy, Competence, and Intrinsic Motivation in Science Education: A Self- Determination Theory Perspective

ERIC Educational Resources Information Center

Painter, Jason

2011-01-01

The purpose of this study was to examine a proposed motivational model of science achievement based on self-determination theory. The study relied on U.S. eighth-grade science data from the 2007 Third International Mathematics and Science Study to examine a structural model that hypothesized how perceived autonomy support, perceived competence in…

The Relation between Self-Concept and Social Functioning in Adolescence

ERIC Educational Resources Information Center

Ybrandt, H.

2008-01-01

A model of the relation between self-concept and internalizing and externalizing problem behaviours in adolescence, with the self-concept influencing problem behaviours (S[right arrow]IE), was assessed using a sample of 277 Swedish adolescents. The model was tested in a path analysis with data from Youth Self Report (YSR) and Structural Analysis…

Simulating Apprenticeship Using Multimedia in Higher Education: A Case from the Information Systems Field

ERIC Educational Resources Information Center

Bider, Ilia; Henkel, Martin; Kowalski, Stewart; Perjons, Erik

2015-01-01

Purpose: This paper aims to report on a project aimed at using simulation for improving the quality of teaching and learning modeling skills. More specifically, the project goal was to facilitate the students to acquire skills of building models of organizational structure and behavior through analysis of internal and external documents, and…

Structural Concepts Study of Non-circular Fuselage Configurations

NASA Technical Reports Server (NTRS)

Mukhopadhyay, Vivel

1996-01-01

A preliminary study of structural concepts for noncircular fuselage configurations is presented. For an unconventional flying-wing type aircraft, in which the fuselage is inside the wing, multiple fuselage bays with non-circular sections need to be considered. In a conventional circular fuselage section, internal pressure is carried efficiently by a thin skin via hoop tension. If the section is non-circular, internal pressure loads also induce large bending stresses. The structure must also withstand additional bending and compression loads from aerodynamic and gravitational forces. Flat and vaulted shell structural configurations for such an unconventional, non-circular pressurized fuselage of a large flying-wing were studied. A deep honeycomb sandwich-shell and a ribbed double-wall shell construction were considered. Combinations of these structural concepts were analyzed using both analytical and simple finite element models of isolated sections for a comparative conceptual study. Weight, stress, and deflection results were compared to identify a suitable configuration for detailed analyses. The flat sandwich-shell concept was found preferable to the vaulted shell concept due to its superior buckling stiffness. Vaulted double-skin ribbed shell configurations were found to be superior due to their weight savings, load diffusion, and fail-safe features. The vaulted double-skin ribbed shell structure concept was also analyzed for an integrated wing-fuselage finite element model. Additional problem areas such as wing-fuselage junction and pressure-bearing spar were identified.

Box Tomography: An efficient tomographic method for imaging localized structures in the deep Earth

NASA Astrophysics Data System (ADS)

Masson, Yder; Romanowicz, Barbara

2017-04-01

The accurate imaging of localized geological structures inside the deep Earth is key to understand our planet and its history. Since the introduction of the Preliminary Reference Earth Model, many generations of global tomographic models have been developed and give us access to the 3D structure of the Earth's interior. The latest generation of global tomographic models has emerged with the development of accurate numerical wavefield computations in a 3D earth combined with access to enhanced HPC capabilities. These models have sharpened up mantle images and unveiled relatively small scale structures that were blurred out in previous generation models. Fingerlike structures have been found at the base of the oceanic asthenosphere, and vertically oriented broad low velocity plume conduits [1] extend throughout the lower mantle beneath those major hotspots that are located within the perimeter of the deep mantle large low shear velocity provinces (LLSVPs). While providing new insights into our understanding of mantle dynamics, the detailed morphology of these features requires further efforts to obtain higher resolution images. In recent years, we developed a theoretical framework [2][3] for the tomographic imaging of localised geological structures buried inside the Earth, where no seismic sources nor receivers are necessarily present. We call this "box tomography" [4]. The essential difference between box-tomography and standard tomographic methods is that the numerical modeling (i.e. the raytracing in travel time tomography and the wave propagation in waveform tomography or full waveform inversion) is completely confined within the small box-region imaged. Thus, box tomography is a lot more efficient than global tomography (i.e. where we invert for the velocity in the larger volume that encompasses all the sources and receivers), for imaging localised objects. We present 2D and 3D examples showing that box tomography can be employed for imaging structures present within the D'' region at the base of the mantle. Further, we show that box-tomography performs well even in the difficult situation where the velocity distribution in the mantle above the target structure is not known a-priori. REFERENCES [1] French, S. W. and B. Romanowicz (2015) Broad Plumes at the base of the mantle beneath major hotspots, Nature, 525, 95-99 [2] Masson, Y., Cupillard, P., Capdeville, Y., & Romanowicz, B. (2013). On the numerical implementation of time-reversal mirrors for tomographic imaging. Geophysical Journal International, ggt459. [3] Masson, Y., & Romanowicz, B. (2017). Fast computation of synthetic seismograms within a medium containing remote localized perturbations: a numerical solution to the scattering problem. Geophysical Journal International, 208(2), 674-692. [4] Masson, Y., & Romanowicz, B. (2017). Box Tomography: Localised imaging of remote targets buried in an unknown medium, a step forward for understanding key structures in the deep Earth. Geophysical Journal International, (under review).

NASA Sun-Earth Connections Theory Program: The Structure and Dynamics of the Solar Corona and Inner Heliosphere

NASA Technical Reports Server (NTRS)

Mikic, Zoran; Grebowsky, Joseph M. (Technical Monitor)

2001-01-01

This report covers technical progress during the fourth quarter of the second year of NASA Sun-Earth Connections Theory Program (SECTP) contract 'The Structure and Dynamics of the Solar Corona and Inner Heliosphere,' NAS5-99188, between NASA and Science Applications International Corporation, and covers the period May 16,2001 to August 15, 2001. Under this contract SAIC and the University of California, Irvine (UCI) have conducted research into theoretical modeling of active regions, the solar corona, and the inner heliosphere, using the MHD model.

The Structure and Dynamics of the Solar Corona and Inner Heliosphere

NASA Technical Reports Server (NTRS)

Mikic, Zoran; Grebowsky, J. (Technical Monitor)

2002-01-01

This report covers technical progress during the fourth quarter of the second year of NASA Sun-Earth Connections Theory Program (SECTP) contract "The Structure and Dynamics of the Solar Corona and Inner Heliosphere," NAS5-99188, between NASA and Science Applications International Corporation (SAIC), and covers the period May 16, 2001 to August 15, 2001. Under this contract SAIC and the University of California, Irvine (UCI) have conducted research into theoretical modeling of active regions, the solar corona, and the inner heliosphere, using the MHD (magnetohydrodynamic) model.

Human Spacecraft Structures Internship

NASA Technical Reports Server (NTRS)

Bhakta, Kush

2017-01-01

DSG will be placed in halo orbit around themoon- Platform for international/commercialpartners to explore lunar surface- Testbed for technologies needed toexplore Mars• Habitat module used to house up to 4crew members aboard the DSG- Launched on EM-3- Placed inside SLS fairing Habitat Module - Task Habitat Finite Element Model Re-modeled entire structure in NX2) Used Beam and Shell elements torepresent the pressure vessel structure3) Created a point cloud of centers of massfor mass components- Can now inspect local moments andinertias for thrust ring application8/ Habitat Structure – Docking Analysis Problem: Artificial Gravity may be necessary forastronaut health in deep spaceGoal: develop concepts that show how artificialgravity might be incorporated into a spacecraft inthe near term Orion Window Radiant Heat Testing.

Dynamic elastic-plastic response of a 2-DOF mass-spring system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corona, Edmundo

The objective of the work presented here arose from abnormal, drop scenarios and specifically the question of how the accelerations and accumulation of plastic strains of internal components could be a ected by the material properties of the external structure. In some scenarios, the impact loads can induce cyclic motion of the internal components. Therefore, a second objective was to explore di erences that could be expected when simulations are conducted using isotropic hardening vs. kinematic hardening plasticity models. The simplest model that can be used to investigate the objectives above is a two-degree-offreedom mass/spring model where the springs exhibitmore » elastic-plastic behavior. The purpose of this memo is to develop such model and present a few results that address the objectives.« less

QSPR for predicting chloroform formation in drinking water disinfection.

PubMed

Luilo, G B; Cabaniss, S E

2011-01-01

Chlorination is the most widely used technique for water disinfection, but may lead to the formation of chloroform (trichloromethane; TCM) and other by-products. This article reports the first quantitative structure-property relationship (QSPR) for predicting the formation of TCM in chlorinated drinking water. Model compounds (n = 117) drawn from 10 literature sources were divided into training data (n = 90, analysed by five-way leave-many-out internal cross-validation) and external validation data (n = 27). QSPR internal cross-validation had Q² = 0.94 and root mean square error (RMSE) of 0.09 moles TCM per mole compound, consistent with external validation Q2 of 0.94 and RMSE of 0.08 moles TCM per mole compound, and met criteria for high predictive power and robustness. In contrast, log TCM QSPR performed poorly and did not meet the criteria for predictive power. The QSPR predictions were consistent with experimental values for TCM formation from tannic acid and for model fulvic acid structures. The descriptors used are consistent with a relatively small number of important TCM precursor structures based upon 1,3-dicarbonyls or 1,3-diphenols.

Fluid Structural Analysis of Human Cerebral Aneurysm Using Their Own Wall Mechanical Properties

PubMed Central

Valencia, Alvaro; Burdiles, Patricio; Ignat, Miguel; Mura, Jorge; Rivera, Rodrigo; Sordo, Juan

2013-01-01

Computational Structural Dynamics (CSD) simulations, Computational Fluid Dynamics (CFD) simulation, and Fluid Structure Interaction (FSI) simulations were carried out in an anatomically realistic model of a saccular cerebral aneurysm with the objective of quantifying the effects of type of simulation on principal fluid and solid mechanics results. Eight CSD simulations, one CFD simulation, and four FSI simulations were made. The results allowed the study of the influence of the type of material elements in the solid, the aneurism's wall thickness, and the type of simulation on the modeling of a human cerebral aneurysm. The simulations use their own wall mechanical properties of the aneurysm. The more complex simulation was the FSI simulation completely coupled with hyperelastic Mooney-Rivlin material, normal internal pressure, and normal variable thickness. The FSI simulation coupled in one direction using hyperelastic Mooney-Rivlin material, normal internal pressure, and normal variable thickness is the one that presents the most similar results with respect to the more complex FSI simulation, requiring one-fourth of the calculation time. PMID:24151523

Bayesian structural inference for hidden processes.

PubMed

Strelioff, Christopher C; Crutchfield, James P

2014-04-01

We introduce a Bayesian approach to discovering patterns in structurally complex processes. The proposed method of Bayesian structural inference (BSI) relies on a set of candidate unifilar hidden Markov model (uHMM) topologies for inference of process structure from a data series. We employ a recently developed exact enumeration of topological ε-machines. (A sequel then removes the topological restriction.) This subset of the uHMM topologies has the added benefit that inferred models are guaranteed to be ε-machines, irrespective of estimated transition probabilities. Properties of ε-machines and uHMMs allow for the derivation of analytic expressions for estimating transition probabilities, inferring start states, and comparing the posterior probability of candidate model topologies, despite process internal structure being only indirectly present in data. We demonstrate BSI's effectiveness in estimating a process's randomness, as reflected by the Shannon entropy rate, and its structure, as quantified by the statistical complexity. We also compare using the posterior distribution over candidate models and the single, maximum a posteriori model for point estimation and show that the former more accurately reflects uncertainty in estimated values. We apply BSI to in-class examples of finite- and infinite-order Markov processes, as well to an out-of-class, infinite-state hidden process.

Bayesian structural inference for hidden processes

NASA Astrophysics Data System (ADS)

Strelioff, Christopher C.; Crutchfield, James P.

2014-04-01

We introduce a Bayesian approach to discovering patterns in structurally complex processes. The proposed method of Bayesian structural inference (BSI) relies on a set of candidate unifilar hidden Markov model (uHMM) topologies for inference of process structure from a data series. We employ a recently developed exact enumeration of topological ɛ-machines. (A sequel then removes the topological restriction.) This subset of the uHMM topologies has the added benefit that inferred models are guaranteed to be ɛ-machines, irrespective of estimated transition probabilities. Properties of ɛ-machines and uHMMs allow for the derivation of analytic expressions for estimating transition probabilities, inferring start states, and comparing the posterior probability of candidate model topologies, despite process internal structure being only indirectly present in data. We demonstrate BSI's effectiveness in estimating a process's randomness, as reflected by the Shannon entropy rate, and its structure, as quantified by the statistical complexity. We also compare using the posterior distribution over candidate models and the single, maximum a posteriori model for point estimation and show that the former more accurately reflects uncertainty in estimated values. We apply BSI to in-class examples of finite- and infinite-order Markov processes, as well to an out-of-class, infinite-state hidden process.

Structure- and ligand-based structure-activity relationships for a series of inhibitors of aldolase.

PubMed

Ferreira, Leonardo G; Andricopulo, Adriano D

2012-12-01

Aldolase has emerged as a promising molecular target for the treatment of human African trypanosomiasis. Over the last years, due to the increasing number of patients infected with Trypanosoma brucei, there is an urgent need for new drugs to treat this neglected disease. In the present study, two-dimensional fragment-based quantitative-structure activity relationship (QSAR) models were generated for a series of inhibitors of aldolase. Through the application of leave-one-out and leave-many-out cross-validation procedures, significant correlation coefficients were obtained (r²=0.98 and q²=0.77) as an indication of the statistical internal and external consistency of the models. The best model was employed to predict pKi values for a series of test set compounds, and the predicted values were in good agreement with the experimental results, showing the power of the model for untested compounds. Moreover, structure-based molecular modeling studies were performed to investigate the binding mode of the inhibitors in the active site of the parasitic target enzyme. The structural and QSAR results provided useful molecular information for the design of new aldolase inhibitors within this structural class.

Complex deformation associated with anhydrite layers in the Tromsø Basin, SW Barents Sea.

NASA Astrophysics Data System (ADS)

Marfo, George; Olakunle Omosanya, Kamaldeen; Johansen, Ståle Emil; Zervas, Ioannis

2017-04-01

Internal and external deformation associated with salt structures is of prime interest due to their economic importance as hydrocarbon seals, reservoirs, repositories for chemical waste and their implication on drilling. Salt structures are often associated with anhydrites, which may 'cap' or are enclosed within the allochthonous salt structures. Despite their economic importance, the internal and external structures of evaporites remain poorly studied from field and seismic data due to the sparse outcrops of evaporites and poor seismic imaging. The zero-phased, normal polarity, high resolution multiple 2D seismic data, in combination with detailed interpretation of wireline logs provide an excellent study into the salt structures, and offers a good opportunity to investigate the dynamics, geometries and mechanisms driving deformation of internal and external salt layers associated with the Late Carboniferous to Early Permian Salt structures in the Tromsø Basin. The methods include seismic interpretation and the application of multiple seismic attributes to map stratigraphic units and discontinuities. Our results show that the anhydrite layers are marked by high amplitude reflections at the crests and flanks or fully enclosed within the salt diapirs. Crestal and lateral anhydrite caprocks represent external salt structures whilst the entrained anhydrites or stringers are intrasalt structures. Anhydrite caprocks generally show structural styles such as faults and large-scale folds which are harmonic to the top salt structure. In contrast, anhydrite stringers show folds of varying scale, which are harmonic to disharmonic to the top salt structure. Boudins and steeply dipping stringer fragments are also interpreted within the stringers. Caprock deformation is attributed to salt upwelling. Folding and boudinaging of originally horizontal and continuous stringer layers formed from a multiphase superimposed sequence of ductile and brittle deformation in response to complex multi-dimensional salt flow. Internal salt flow involves radial and tangential compression, which leads to dominant fold structures near the margins. Boudins on the lower flanks of the diapir formed due radial extension. Our study further demonstrates that differential geometries exhibited by the different anhydrite groups imply that the mechanisms deforming internal and external salt structures are different. The results from this study are comparable to observations from salt mines, field exposures, scaled physical and numerical models.

Effective model development of internal auditors in the village financial institution

NASA Astrophysics Data System (ADS)

Arsana, I. M. M.; Sugiarta, I. N.

2018-01-01

Designing an effective audit system is complex and challenging, and a focus on examining how internal audit drive improvement in three core performance dimensions ethicality, efficiency, and effectiveness in organization is needed. The problem of research is how the desain model and peripheral of supporter of effective supervation Village Credit Institution? Research of objectives is yielding the desain model and peripheral of supporter of effective supervation Village Credit Institution. Method Research use data collecting technique interview, observation and enquette. Data analysis, data qualitative before analysed to be turned into quantitative data in the form of scale. Each variable made to become five classificat pursuant to scale of likert. Data analysed descriptively to find supervation level, Structural Equation Model (SEM) to find internal and eksternal factor. So that desain model supervation with descriptive analysis. Result of research desain model and peripheral of supporter of effective supervation Village Credit Institution. The conclusion desain model supported by three sub system: sub system institute yield body supervisor of Village Credit Institution, sub system standardization and working procedure yield standard operating procedure supervisor of Village Credit Institution, sub system education and training yield supervisor professional of Village Credit Institution.

An atomic model of brome mosaic virus using direct electron detection and real-space optimization.

PubMed

Wang, Zhao; Hryc, Corey F; Bammes, Benjamin; Afonine, Pavel V; Jakana, Joanita; Chen, Dong-Hua; Liu, Xiangan; Baker, Matthew L; Kao, Cheng; Ludtke, Steven J; Schmid, Michael F; Adams, Paul D; Chiu, Wah

2014-09-04

Advances in electron cryo-microscopy have enabled structure determination of macromolecules at near-atomic resolution. However, structure determination, even using de novo methods, remains susceptible to model bias and overfitting. Here we describe a complete workflow for data acquisition, image processing, all-atom modelling and validation of brome mosaic virus, an RNA virus. Data were collected with a direct electron detector in integrating mode and an exposure beyond the traditional radiation damage limit. The final density map has a resolution of 3.8 Å as assessed by two independent data sets and maps. We used the map to derive an all-atom model with a newly implemented real-space optimization protocol. The validity of the model was verified by its match with the density map and a previous model from X-ray crystallography, as well as the internal consistency of models from independent maps. This study demonstrates a practical approach to obtain a rigorously validated atomic resolution electron cryo-microscopy structure.

Approaches to the structural modelling of insect wings.

PubMed Central

Wootton, R J; Herbert, R C; Young, P G; Evans, K E

2003-01-01

Insect wings lack internal muscles, and the orderly, necessary deformations which they undergo in flight and folding are in part remotely controlled, in part encoded in their structure. This factor is crucial in understanding their complex, extremely varied morphology. Models have proved particularly useful in clarifying the facilitation and control of wing deformation. Their development has followed a logical sequence from conceptual models through physical and simple analytical to numerical models. All have value provided their limitations are realized and constant comparisons made with the properties and mechanical behaviour of real wings. Numerical modelling by the finite element method is by far the most time-consuming approach, but has real potential in analysing the adaptive significance of structural details and interpreting evolutionary trends. Published examples are used to review the strengths and weaknesses of each category of model, and a summary is given of new work using finite element modelling to investigate the vibration properties and response to impact of hawkmoth wings. PMID:14561349

Laboratory evaluation of friction loss and compactability of asphalt mixtures.

DOT National Transportation Integrated Search

2012-04-01

This study aimed to develop prediction models for friction loss and laboratory compaction of asphalt : mixtures. In addition, the study evaluated the effect of compaction level and compaction method of skid : resistance and the internal structure of ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stavros, E. Natasha; Schimel, David; Pavlick, Ryan

Technologies on the International Space Station will provide ~1 year of synchronous observations of ecosystem composition, structure and function, in 2018. Here, we discuss these instruments and how they can be used to constrain global models and improve our understanding of the current state of terrestrial ecosystems.

Uncertainties in Future Regional Sea Level Trends: How to Deal with the Internal Climate Variability?

NASA Astrophysics Data System (ADS)

Becker, M.; Karpytchev, M.; Hu, A.; Deser, C.; Lennartz-Sassinek, S.

2017-12-01

Today, the Climate models (CM) are the main tools for forecasting sea level rise (SLR) at global and regional scales. The CM forecasts are accompanied by inherent uncertainties. Understanding and reducing these uncertainties is becoming a matter of increasing urgency in order to provide robust estimates of SLR impact on coastal societies, which need sustainable choices of climate adaptation strategy. These CM uncertainties are linked to structural model formulation, initial conditions, emission scenario and internal variability. The internal variability is due to complex non-linear interactions within the Earth Climate System and can induce diverse quasi-periodic oscillatory modes and long-term persistences. To quantify the effects of internal variability, most studies used multi-model ensembles or sea level projections from a single model ran with perturbed initial conditions. However, large ensembles are not generally available, or too small, and computationally expensive. In this study, we use a power-law scaling of sea level fluctuations, as observed in many other geophysical signals and natural systems, which can be used to characterize the internal climate variability. From this specific statistical framework, we (1) use the pre-industrial control run of the National Center for Atmospheric Research Community Climate System Model (NCAR-CCSM) to test the robustness of the power-law scaling hypothesis; (2) employ the power-law statistics as a tool for assessing the spread of regional sea level projections due to the internal climate variability for the 21st century NCAR-CCSM; (3) compare the uncertainties in predicted sea level changes obtained from a NCAR-CCSM multi-member ensemble simulations with estimates derived for power-law processes, and (4) explore the sensitivity of spatial patterns of the internal variability and its effects on regional sea level projections.

Building a pantheoretical model of dehumanization with transgender men: Integrating objectification and minority stress theories.

PubMed

Velez, Brandon L; Breslow, Aaron S; Brewster, Melanie E; Cox, Robert; Foster, Aasha B

2016-10-01

With a national sample of 304 transgender men, the present study tested a pantheoretical model of dehumanization (Moradi, 2013) with hypotheses derived from objectification theory (Fredrickson & Roberts, 1997), minority stress theory (Meyer, 2003), and prior research regarding men's body image concerns. Specifically, we tested common objectification theory constructs (internalization of sociocultural standards of attractiveness [SSA], body surveillance, body satisfaction) as direct and indirect predictors of compulsive exercise. We also examined the roles of transgender-specific minority stress variables-antitransgender discrimination and transgender identity congruence-in the model. Results of a latent variable structural equation model yielded mixed support for the posited relations. The direct and indirect interrelations of internalization of SSA, body surveillance, and body satisfaction were consistent with prior objectification theory research, but only internalization of SSA yielded a significant direct relation with compulsive exercise. In addition, neither internalization of SSA nor body surveillance yielded significant indirect relations with compulsive exercise. However, antitransgender discrimination yielded predicted indirect relations with body surveillance, body satisfaction, and compulsive exercise, with transgender congruence playing a key mediating role in most of these relations. The implications of this pantheoretical model for research and practice with transgender men are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The Interiors of Jupiter and Saturn

NASA Astrophysics Data System (ADS)

Helled, Ravit

2018-05-01

Probing the interiors of the giant planets in our Solar System is not an easy task. This requires a set of observations combined with theoretical models that are used to infer the planetary composition and its depth dependence. The masses of Jupiter and Saturn are 318 and 96 Earth masses, respectively, and since a few decades, we know that they mostly consist of hydrogen and helium. It is the mass of heavy elements (all elements heavier than helium) that is not well determined, as well as its distribution within the planets. While the heavy elements are not the dominating materials in Jupiter and Saturn, they are the key for our understanding of their formation and evolution histories. The planetary internal structure is inferred to fit the available observational constraints including the planetary masses, radii, 1-bar temperatures, rotation rates, and gravitational fields. Then, using theoretical equations of states (EOSs) for hydrogen, helium, their mixtures, and heavier elements (typically rocks and/or ices), a structure model is developed. However, there is no unique solution for the planetary structure, and the results depend on the used EOSs and the model assumptions imposed by the modeler. Standard interior models of Jupiter and Saturn include three main regions: (1) the central region (core) that consists of heavy elements, (2) an inner metallic hydrogen envelope that is helium rich, and (3) an outer molecular hydrogen envelope depleted with helium. The distribution of heavy elements can be either homogenous or discontinuous between the two envelopes. Major model assumptions that can affect the derived internal structure include the number of layers, the heat transport mechanism within the planet (and its entropy), the nature of the core (compact vs. diluted), and the location/pressure where the envelopes are divided. Alternative structure models assume a less distinct division between the layers and/or a less non-homogenous distribution of the heavy elements. The fact that the behavior of hydrogen at high pressures and temperatures in not perfectly known, and that helium separates from hydrogen at the deep interior add sources of uncertainties to the interior model. Today, with accurate measurements of the gravitational fields of Jupiter and Saturn from the Juno and Cassini missions, structure models can be further constrained. At the same time, these measurements introduce new challenges and open question for planetary modelers.

Moderators, mediators, and bidirectional relationships in the International Classification of Functioning, Disability and Health (ICF) framework: An empirical investigation using a longitudinal design and Structural Equation Modeling (SEM).

PubMed

Rouquette, Alexandra; Badley, Elizabeth M; Falissard, Bruno; Dub, Timothée; Leplege, Alain; Coste, Joël

2015-06-01

The International Classification of Functioning, Disability and Health (ICF) published in 2001 describes the consequences of health conditions with three components of impairments in body structures or functions, activity limitations and participation restrictions. Two of the new features of the conceptual model were the possibility of feedback effects between each ICF component and the introduction of contextual factors conceptualized as moderators of the relationship between the components. The aim of this longitudinal study is to provide empirical evidence of these two kinds of effect. Structural equation modeling was used to analyze data from a French population-based cohort of 548 patients with knee osteoarthritis recruited between April 2007 and March 2009 and followed for three years. Indicators of the body structure and function, activity and participation components of the ICF were derived from self-administered standardized instruments. The measurement model revealed four separate factors for body structures impairments, body functions impairments, activity limitations and participation restrictions. The classic sequence from body impairments to participation restrictions through activity limitations was found at each assessment time. Longitudinal study of the ICF component relationships showed a feedback pathway indicating that the level of participation restrictions at baseline was predictive of activity limitations three years later. Finally, the moderating role of personal (age, sex, mental health, etc.) and environmental factors (family relationships, mobility device use, etc.) was investigated. Three contextual factors (sex, family relationships and walking stick use) were found to be moderators for the relationship between the body impairments and the activity limitations components. Mental health was found to be a mediating factor of the effect of activity limitations on participation restrictions. Copyright © 2015 Elsevier Ltd. All rights reserved.

Automated identification of RNA 3D modules with discriminative power in RNA structural alignments.

PubMed

Theis, Corinna; Höner Zu Siederdissen, Christian; Hofacker, Ivo L; Gorodkin, Jan

2013-12-01

Recent progress in predicting RNA structure is moving towards filling the 'gap' in 2D RNA structure prediction where, for example, predicted internal loops often form non-canonical base pairs. This is increasingly recognized with the steady increase of known RNA 3D modules. There is a general interest in matching structural modules known from one molecule to other molecules for which the 3D structure is not known yet. We have created a pipeline, metaRNAmodules, which completely automates extracting putative modules from the FR3D database and mapping of such modules to Rfam alignments to obtain comparative evidence. Subsequently, the modules, initially represented by a graph, are turned into models for the RMDetect program, which allows to test their discriminative power using real and randomized Rfam alignments. An initial extraction of 22 495 3D modules in all PDB files results in 977 internal loop and 17 hairpin modules with clear discriminatory power. Many of these modules describe only minor variants of each other. Indeed, mapping of the modules onto Rfam families results in 35 unique locations in 11 different families. The metaRNAmodules pipeline source for the internal loop modules is available at http://rth.dk/resources/mrm.

Development and Evaluation of the Telephone Crisis Support Skills Scale.

PubMed

Kitchingman, Taneile A; Wilson, Coralie J; Caputi, Peter; Woodward, Alan; Hunt, Tara

2015-01-01

Although telephone services continue to play an important role in the delivery of front-line crisis support, published evidence of the standardized assessment of such services does not exist to date. To describe the development of the Telephone Crisis Support Skills Scale (TCSSS), an instrument to assess workers' intentions to use recommended skills with callers, and to evaluate its factor structure and reliability. TCSSS items were mapped to a national telephone crisis support practice model. A national sample of workers (n = 210) completed the TCSSS as part of a larger online survey. Principal axis factoring was used to evaluate the structure of the instrument. Internal consistency was assessed by Cronbach's α values. A single factor accounted for more than 40% of the variance within TCSSS ratings, indicating unidimensional structure. Cronbach's α coefficients suggested adequate internal consistency. Results indicate that the TCSSS is an internally consistent, unidimensional scale, sufficiently sensitive to detect workers' skill priorities for different caller problem types. Further study is required to confirm the factor structure and reliability of the TCSSS using workers from different organizations. Following further evaluation, the TCSSS may be applied to assessing readiness for and quality of service delivery.

What's Next: Recruitment of a Grounded Predictive Body Model for Planning a Robot's Actions.

PubMed

Schilling, Malte; Cruse, Holk

2012-01-01

Even comparatively simple, reactive systems are able to control complex motor tasks, such as hexapod walking on unpredictable substrate. The capability of such a controller can be improved by introducing internal models of the body and of parts of the environment. Such internal models can be applied as inverse models, as forward models or to solve the problem of sensor fusion. Usually, separate models are used for these functions. Furthermore, separate models are used to solve different tasks. Here we concentrate on internal models of the body as the brain considers its own body the most important part of the world. The model proposed is formed by a recurrent neural network with the property of pattern completion. The model shows a hierarchical structure but nonetheless comprises a holistic system. One and the same model can be used as a forward model, as an inverse model, for sensor fusion, and, with a simple expansion, as a model to internally simulate (new) behaviors to be used for prediction. The model embraces the geometrical constraints of a complex body with many redundant degrees of freedom, and allows finding geometrically possible solutions. To control behavior such as walking, climbing, or reaching, this body model is complemented by a number of simple reactive procedures together forming a procedural memory. In this article, we illustrate the functioning of this network. To this end we present examples for solutions of the forward function and the inverse function, and explain how the complete network might be used for predictive purposes. The model is assumed to be "innate," so learning the parameters of the model is not (yet) considered.

Personality and the latent structure of PTSD comorbidity

PubMed Central

Miller, Mark W.; Wolf, Erika J.

2012-01-01

This study examined the structure of PTSD comorbidity and its relationship to personality in a sample of 214 veterans using data from diagnostic interviews and the Multidimensional Personality Questionnaire-Brief Form (MPQ-BF; Patrick, Curtin, & Tellegen, 2002). Confirmatory factor analyses supported a three factor model composed of Externalizing, Fear and Distress factors. Analyses that examined the location of borderline personality disorder revealed significant cross-loadings for this disorder on both Externalizing and Distress. Structural equation models showed trait negative emotionality to be significantly related to all three comorbidity factors whereas positive emotionality and constraint evidenced specific associations with Distress and Externalizing, respectively. These results shed new light on the location of borderline personality disorder within the internalizing/externalizing model and clarify the relative influence of broad dimensions of personality on patterns of comorbidity. PMID:22480716

Hubble space telescope observations and geometric models of compact multipolar planetary nebulae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsia, Chih-Hao; Chau, Wayne; Zhang, Yong

2014-05-20

We report high angular resolution Hubble Space Telescope observations of 10 compact planetary nebulae (PNs). Many interesting internal structures, including multipolar lobes, arcs, two-dimensional rings, tori, and halos, are revealed for the first time. These results suggest that multipolar structures are common among PNs, and these structures develop early in their evolution. From three-dimensional geometric models, we have determined the intrinsic dimensions of the lobes. Assuming the lobes are the result of interactions between later-developed fast winds and previously ejected asymptotic giant branch winds, the geometric structures of these PNs suggest that there are multiple phases of fast winds separatedmore » by temporal variations and/or directional changes. A scenario of evolution from lobe-dominated to cavity-dominated stages is presented. The results reported here will provide serious constraints on any dynamical models of PNs.« less

Development and validation of a Housing First fidelity survey.

PubMed

Gilmer, Todd P; Stefancic, Ana; Sklar, Marisa; Tsemberis, Sam

2013-09-01

Programs that use the Housing First model are being implemented throughout the United States and internationally. The authors describe the development and validation of a Housing First fidelity survey. A 46-item survey was developed to measure fidelity across five domains: housing process and structure, separation of housing and services, service philosophy, service array, and team structure. The survey was administered to staff and clients of 93 supported-housing programs in California. Exploratory and confirmatory factor analyses were used to identify the items and model structure that best fit the data. Sixteen items were retained in a two-factor model, one related to approach to housing, separation of housing and services, and service philosophy and one related to service array and team structure. Our survey mapped program practices by using a common metric that captured variation in fidelity to Housing First across a large-scale implementation of supported-housing programs.

The International Gravity Field Service (IGFS): Present Day Activities And Future Plans

NASA Astrophysics Data System (ADS)

Barzaghi, R.; Vergos, G. S.

2016-12-01

IGFS is a unified "umbrella" IAG service that coordinates the servicing of the geodetic and geophysical community with gravity field related data, software and information. The combined data of the IGFS entities will include global geopotential models, terrestrial, airborne, satellite and marine gravity observations, Earth tide data, GPS/levelling data, digital models of terrain and bathymetry, as well as ocean gravity field and geoid from satellite altimetry. The IGFS structure is based on the Gravity Services, the "operating arms" of IGFS. These Services related to IGFS are: BGI (Bureau Gravimetrique International), Toulouse, France ISG (International Service for the Geoid), Politecnico di Milano, Milano, Italy IGETS (International Geodynamics and Earth Tides Service), EOST, Strasbourg, France ICGEM (International Center for Global Earth Models), GFZ, Potsdam, Germany IDEMS (International Digital Elevation Model Service), ESRI, Redlands, CA, USA The Central Bureau, hosted at the Aristotle Thessaloniki University, is in charge for all the interactions among the services and the other IAG bodies, particularly GGOS. In this respect, connections with the GGOS Bureaus of Products and Standards and of Networks and Observations have been recently strengthened in order to align the Gravity services to the GGOS standards. IGFS is also strongly involved in the most relevant projects related to the gravity field such as the establishment of the new Global Absolute Gravity Reference System and of the International Height Reference System. These projects, along with the organization of Geoid Schools devoted to methods for gravity and geoid estimate, will play a central role in the IGFS future actions in the framework of GGOS.

A Corner-Point-Grid-Based Voxelization Method for Complex Geological Structure Model with Folds

NASA Astrophysics Data System (ADS)

Chen, Qiyu; Mariethoz, Gregoire; Liu, Gang

2017-04-01

3D voxelization is the foundation of geological property modeling, and is also an effective approach to realize the 3D visualization of the heterogeneous attributes in geological structures. The corner-point grid is a representative data model among all voxel models, and is a structured grid type that is widely applied at present. When carrying out subdivision for complex geological structure model with folds, we should fully consider its structural morphology and bedding features to make the generated voxels keep its original morphology. And on the basis of which, they can depict the detailed bedding features and the spatial heterogeneity of the internal attributes. In order to solve the shortage of the existing technologies, this work puts forward a corner-point-grid-based voxelization method for complex geological structure model with folds. We have realized the fast conversion from the 3D geological structure model to the fine voxel model according to the rule of isocline in Ramsay's fold classification. In addition, the voxel model conforms to the spatial features of folds, pinch-out and other complex geological structures, and the voxels of the laminas inside a fold accords with the result of geological sedimentation and tectonic movement. This will provide a carrier and model foundation for the subsequent attribute assignment as well as the quantitative analysis and evaluation based on the spatial voxels. Ultimately, we use examples and the contrastive analysis between the examples and the Ramsay's description of isoclines to discuss the effectiveness and advantages of the method proposed in this work when dealing with the voxelization of 3D geologic structural model with folds based on corner-point grids.

ICD-11 and DSM-5 personality trait domains capture categorical personality disorders: Finding a common ground.

PubMed

Bach, Bo; Sellbom, Martin; Skjernov, Mathias; Simonsen, Erik

2018-05-01

The five personality disorder trait domains in the proposed International Classification of Diseases, 11th edition and the Diagnostic and Statistical Manual of Mental Disorders, 5th edition are comparable in terms of Negative Affectivity, Detachment, Antagonism/Dissociality and Disinhibition. However, the International Classification of Diseases, 11th edition model includes a separate domain of Anankastia, whereas the Diagnostic and Statistical Manual of Mental Disorders, 5th edition model includes an additional domain of Psychoticism. This study examined associations of International Classification of Diseases, 11th edition and Diagnostic and Statistical Manual of Mental Disorders, 5th edition trait domains, simultaneously, with categorical personality disorders. Psychiatric outpatients ( N = 226) were administered the Structured Clinical Interview for DSM-IV Axis II Personality Disorders Interview and the Personality Inventory for DSM-5. International Classification of Diseases, 11th edition and Diagnostic and Statistical Manual of Mental Disorders, 5th edition trait domain scores were obtained using pertinent scoring algorithms for the Personality Inventory for DSM-5. Associations between categorical personality disorders and trait domains were examined using correlation and multiple regression analyses. Both the International Classification of Diseases, 11th edition and the Diagnostic and Statistical Manual of Mental Disorders, 5th edition domain models showed relevant continuity with categorical personality disorders and captured a substantial amount of their information. As expected, the International Classification of Diseases, 11th edition model was superior in capturing obsessive-compulsive personality disorder, whereas the Diagnostic and Statistical Manual of Mental Disorders, 5th edition model was superior in capturing schizotypal personality disorder. These preliminary findings suggest that little information is 'lost' in a transition to trait domain models and potentially adds to narrowing the gap between Diagnostic and Statistical Manual of Mental Disorders, 5th edition and the proposed International Classification of Diseases, 11th edition model. Accordingly, the International Classification of Diseases, 11th edition and Diagnostic and Statistical Manual of Mental Disorders, 5th edition domain models may be used to delineate one another as well as features of familiar categorical personality disorder types. A preliminary category-to-domain 'cross walk' is provided in the article.

Internal quantum efficiency in yellow-amber light emitting AlGaN-InGaN-GaN heterostructures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ngo, Thi Huong; Gil, Bernard; Valvin, Pierre

2015-09-21

We determine the internal quantum efficiency of strain-balanced AlGaN-InGaN-GaN hetero-structures designed for yellow-amber light emission, by using a recent model based on the kinetics of the photoluminescence decay initiated by Iwata et al. [J. Appl. Phys. 117, 075701 (2015)]. Our results indicate that low temperature internal quantum efficiencies sit in the 50% range and we measure that adding an AlGaN layer increases the internal quantum efficiency from 50% up to 57% with respect to the GaN-InGaN case. More dramatic, it almost doubles from 2.5% up to 4.3% at room temperature.

Manifestation of the shape-memory effect in polyetherurethane cellular plastics, fabric composites, and sandwich structures under microgravity

NASA Astrophysics Data System (ADS)

Babaevskii, P. G.; Kozlov, N. A.; Agapov, I. G.; Reznichenko, G. M.; Churilo, N. V.; Churilo, I. V.

2016-09-01

The results of experiments that were performed to test the feasibility of creating sandwich structures (consisting of thin-layer sheaths of polymer composites and a cellular polymer core) with the shapememory effect as models of the transformable components of space structures have been given. The data obtained indicate that samples of sandwich structures under microgravity conditions on board the International Space Station have recovered their shape to almost the same degree as under terrestrial conditions, which makes it possible to recommend them for creating components of transformable space structures on their basis.

Construction of a memory battery for computerized administration, using item response theory.

PubMed

Ferreira, Aristides I; Almeida, Leandro S; Prieto, Gerardo

2012-10-01

In accordance with Item Response Theory, a computer memory battery with six tests was constructed for use in the Portuguese adult population. A factor analysis was conducted to assess the internal structure of the tests (N = 547 undergraduate students). According to the literature, several confirmatory factor models were evaluated. Results showed better fit of a model with two independent latent variables corresponding to verbal and non-verbal factors, reproducing the initial battery organization. Internal consistency reliability for the six tests were alpha = .72 to .89. IRT analyses (Rasch and partial credit models) yielded good Infit and Outfit measures and high precision for parameter estimation. The potential utility of these memory tasks for psychological research and practice willbe discussed.

A simple 2D biofilm model yields a variety of morphological features.

PubMed

Hermanowicz, S W

2001-01-01

A two-dimensional biofilm model was developed based on the concept of cellular automata. Three simple, generic processes were included in the model: cell growth, internal and external mass transport and cell detachment (erosion). The model generated a diverse range of biofilm morphologies (from dense layers to open, mushroom-like forms) similar to those observed in real biofilm systems. Bulk nutrient concentration and external mass transfer resistance had a large influence on the biofilm structure.

Transparent model of temporal bone and vestibulocochlear organ made by 3D printing.

PubMed

Suzuki, Ryoji; Taniguchi, Naoto; Uchida, Fujio; Ishizawa, Akimitsu; Kanatsu, Yoshinori; Zhou, Ming; Funakoshi, Kodai; Akashi, Hideo; Abe, Hiroshi

2018-01-01

The vestibulocochlear organ is composed of tiny complex structures embedded in the petrous part of the temporal bone. Landmarks on the temporal bone surface provide the only orientation guide for dissection, but these need to be removed during the course of dissection, making it difficult to grasp the underlying three-dimensional structures, especially for beginners during gross anatomy classes. We report herein an attempt to produce a transparent three-dimensional-printed model of the human ear. En bloc samples of the temporal bone from donated cadavers were subjected to computed tomography (CT) scanning, and on the basis of the data, the surface temporal bone was reconstructed with transparent resin and the vestibulocochlear organ with white resin to create a 1:1.5 scale model. The carotid canal was stuffed with red cotton, and the sigmoid sinus and internal jugular vein were filled with blue clay. In the inner ear, the internal acoustic meatus, cochlea, and semicircular canals were well reconstructed in detail with white resin. The three-dimensional relationships of the semicircular canals, spiral turns of the cochlea, and internal acoustic meatus were well recognizable from every direction through the transparent surface resin. The anterior semicircular canal was obvious immediately beneath the arcuate eminence, and the topographical relationships of the vestibulocochlear organ and adjacent great vessels were easily discernible. We consider that this transparent temporal bone model will be a very useful aid for better understanding of the gross anatomy of the vestibulocochlear organ.

Roles of Shape and Internal Structure in Rotational Disruption of Asteroids

NASA Astrophysics Data System (ADS)

Hirabayashi, Masatoshi; Scheeres, Daniel Jay

2015-08-01

An active research area over the last decade has been to explore configuration changes of rubble pile asteroids due to rotationally induced disruption, initially driven by the remarkable fact that there is a spin period threshold of 2 hr for asteroids larger than a few hundred meters in size. Several different disruption modes due to rapid rotation can be identified, as surface shedding, fission and failure of the internal structure. Relevant to these discussions are many observations of asteroid shapes that have revealed a diversity of forms such as oblate spheroids with equatorial ridges, strongly elongated shapes and contact binaries, to say nothing of multi-body systems. With consideration that rotationally induced deformation is one of the primary drivers of asteroid evolution, we have been developing two techniques for investigating the structure of asteroids, while accounting for their internal mechanical properties through plastic theory. The first technique developed is an analytical model based on limit analysis, which provides rigorous bounds on the asteroid mechanical properties for their shapes to remain stable. The second technique applies finite element model analysis that accounts for plastic deformation. Combining these models, we have explored the correlation between unique shape features and failure modes. First, we have been able to show that contact binary asteroids preferentially fail at their narrow necks at a relatively slow spin period, due to stress concentration. Second, applying these techniques to the breakup event of active asteroid P/2013 R3, we have been able to develop explicit constraints on the cohesion within rubble pile asteroids. Third, by probing the effect of inhomogeneous material properties, we have been able to develop conditions for whether an oblate body will fail internally or through surface shedding. These different failure modes can be tested by measuring the density distribution within a rubble pile body through determination of its gravity field. This talk will explore these different modes of failure and motivate divergent theories of failure that depend on properties of rubble piles.

Investigation of Particle Deposition in Internal Cooling Cavities of a Nozzle Guide Vane

NASA Astrophysics Data System (ADS)

Casaday, Brian Patrick

Experimental and computational studies were conducted regarding particle deposition in the internal film cooling cavities of nozzle guide vanes. An experimental facility was fabricated to simulate particle deposition on an impingement liner and upstream surface of a nozzle guide vane wall. The facility supplied particle-laden flow at temperatures up to 1000°F (540°C) to a simplified impingement cooling test section. The heated flow passed through a perforated impingement plate and impacted on a heated flat wall. The particle-laden impingement jets resulted in the buildup of deposit cones associated with individual impingement jets. The deposit growth rate increased with increasing temperature and decreasing impinging velocities. For some low flow rates or high flow temperatures, the deposit cones heights spanned the entire gap between the impingement plate and wall, and grew through the impingement holes. For high flow rates, deposit structures were removed by shear forces from the flow. At low temperatures, deposit formed not only as individual cones, but as ridges located at the mid-planes between impinging jets. A computational model was developed to predict the deposit buildup seen in the experiments. The test section geometry and fluid flow from the experiment were replicated computationally and an Eulerian-Lagrangian particle tracking technique was employed. Several particle sticking models were employed and tested for adequacy. Sticking models that accurately predicted locations and rates in external deposition experiments failed to predict certain structures or rates seen in internal applications. A geometry adaptation technique was employed and the effect on deposition prediction was discussed. A new computational sticking model was developed that predicts deposition rates based on the local wall shear. The growth patterns were compared to experiments under different operating conditions. Of all the sticking models employed, the model based on wall shear, in conjunction with geometry adaptation, proved to be the most accurate in predicting the forms of deposit growth. It was the only model that predicted the changing deposition trends based on flow temperature or Reynolds number, and is recommended for further investigation and application in the modeling of deposition in internal cooling cavities.

Fluids and Combustion Facility: Combustion Integrated Rack Modal Model Correlation

NASA Technical Reports Server (NTRS)

McNelis, Mark E.; Suarez, Vicente J.; Sullivan, Timothy L.; Otten, Kim D.; Akers, James C.

2005-01-01

The Fluids and Combustion Facility (FCF) is a modular, multi-user, two-rack facility dedicated to combustion and fluids science in the US Laboratory Destiny on the International Space Station. FCF is a permanent facility that is capable of accommodating up to ten combustion and fluid science investigations per year. FCF research in combustion and fluid science supports NASA's Exploration of Space Initiative for on-orbit fire suppression, fire safety, and space system fluids management. The Combustion Integrated Rack (CIR) is one of two racks in the FCF. The CIR major structural elements include the International Standard Payload Rack (ISPR), Experiment Assembly (optics bench and combustion chamber), Air Thermal Control Unit (ATCU), Rack Door, and Lower Structure Assembly (Input/Output Processor and Electrical Power Control Unit). The load path through the rack structure is outlined. The CIR modal survey was conducted to validate the load path predicted by the CIR finite element model (FEM). The modal survey is done by experimentally measuring the CIR frequencies and mode shapes. The CIR model was test correlated by updating the model to represent the test mode shapes. The correlated CIR model delivery is required by NASA JSC at Launch-10.5 months. The test correlated CIR flight FEM is analytically integrated into the Shuttle for a coupled loads analysis of the launch configuration. The analysis frequency range of interest is 0-50 Hz. A coupled loads analysis is the analytical integration of the Shuttle with its cargo element, the Mini Payload Logistics Module (MPLM), in the Shuttle cargo bay. For each Shuttle launch configuration, a verification coupled loads analysis is performed to determine the loads in the cargo bay as part of the structural certification process.

Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling.

PubMed

Dittmore, Andrew; Silver, Jonathan; Sarkar, Susanta K; Marmer, Barry; Goldberg, Gregory I; Neuman, Keir C

2016-07-26

Fibrillar collagen, an essential structural component of the extracellular matrix, is remarkably resistant to proteolysis, requiring specialized matrix metalloproteinases (MMPs) to initiate its remodeling. In the context of native fibrils, remodeling is poorly understood; MMPs have limited access to cleavage sites and are inhibited by tension on the fibril. Here, single-molecule recordings of fluorescently labeled MMPs reveal cleavage-vulnerable binding regions arrayed periodically at ∼1-µm intervals along collagen fibrils. Binding regions remain periodic even as they migrate on the fibril, indicating a collective process of thermally activated and self-healing defect formation. An internal strain relief model involving reversible structural rearrangements quantitatively reproduces the observed spatial patterning and fluctuations of defects and provides a mechanism for tension-dependent stabilization of fibrillar collagen. This work identifies internal-strain-driven defects that may have general and widespread regulatory functions in self-assembled biological filaments.

Probing Membrane Order and Topography in Supported Lipid Bilayers by Combined Polarized Total Internal Reflection Fluorescence-Atomic Force Microscopy

PubMed Central

Oreopoulos, John; Yip, Christopher M.

2009-01-01

Determining the local structure, dynamics, and conformational requirements for protein-protein and protein-lipid interactions in membranes is critical to understanding biological processes ranging from signaling to the translocating and membranolytic action of antimicrobial peptides. We report here the application of a combined polarized total internal reflection fluorescence microscopy-in situ atomic force microscopy platform. This platform's ability to image membrane orientational order was demonstrated on DOPC/DSPC/cholesterol model membranes containing the fluorescent membrane probe, DiI-C20 or BODIPY-PC. Spatially resolved order parameters and fluorophore tilt angles extracted from the polarized total internal reflection fluorescence microscopy images were in good agreement with the topographical details resolved by in situ atomic force microscopy, portending use of this technique for high-resolution characterization of membrane domain structures and peptide-membrane interactions. PMID:19254557

Space Shuttle Redesigned Solid Rocket Motor nozzle natural frequency variations with burn time

NASA Technical Reports Server (NTRS)

Lui, C. Y.; Mason, D. R.

1991-01-01

The effects of erosion and thermal degradation on the Space Shuttle Redesigned Solid Rocket Motor (RSRM) nozzle's structural dynamic characteristics were analytically evaluated. Also considered was stiffening of the structure due to internal pressurization. A detailed NASTRAN finite element model of the nozzle was developed and used to evaluate the influence of these effects at several discrete times during motor burn. Methods were developed for treating erosion and thermal degradation, and a procedure was developed to account for internal pressure stiffening using differential stiffness matrix techniques. Results were verified using static firing test accelerometer data. Fast Fourier Transform and Maximum Entropy Method techniques were applied to the data to generate waterfall plots which track modal frequencies with burn time. Results indicate that the lower frequency nozzle 'vectoring' modes are only slightly affected by erosion, thermal effects and internal pressurization. The higher frequency shell modes of the nozzle are, however, significantly reduced.

Depression Anxiety Stress Scales (DASS-21): Factor Structure in Traumatic Brain Injury Rehabilitation.

PubMed

Randall, Diane; Thomas, Matt; Whiting, Diane; McGrath, Andrew

To confirm the construct validity of the Depression Anxiety Stress Scales-21 (DASS-21) by investigating the fit of published factor structures in a sample of adults with moderate to severe traumatic brain injury (posttraumatic amnesia > 24 hours). Archival data from 504 patient records at the Brain Injury Rehabilitation Unit at Liverpool Hospital, Australia. Participants were aged between 16 and 71 years and were engaged in a specialist rehabilitation program. The DASS-21. Two of the 6 models had adequate fit using structural equation modeling. The data best fit Henry and Crawford's quadripartite model, which comprised a Depression, Anxiety and Stress factor, as well as a General Distress factor. The data also adequately fit Lovibond and Lovibond's original 3-factor model, and the internal consistencies of each factor were very good (α = 0.82-0.90). This study confirms the structure and construct validity of the DASS-21 and provides support for its use as a screening tool in traumatic brain injury rehabilitation.

Active influence in dynamical models of structural balance in social networks

NASA Astrophysics Data System (ADS)

Summers, Tyler H.; Shames, Iman

2013-07-01

We consider a nonlinear dynamical system on a signed graph, which can be interpreted as a mathematical model of social networks in which the links can have both positive and negative connotations. In accordance with a concept from social psychology called structural balance, the negative links play a key role in both the structure and dynamics of the network. Recent research has shown that in a nonlinear dynamical system modeling the time evolution of “friendliness levels” in the network, two opposing factions emerge from almost any initial condition. Here we study active external influence in this dynamical model and show that any agent in the network can achieve any desired structurally balanced state from any initial condition by perturbing its own local friendliness levels. Based on this result, we also introduce a new network centrality measure for signed networks. The results are illustrated in an international-relations network using United Nations voting record data from 1946 to 2008 to estimate friendliness levels amongst various countries.

Thermal analyses of the International Ultraviolet Explorer (IUE) scientific instrument using the NASTRAN thermal analyzer (NTA): A general purpose summary

NASA Technical Reports Server (NTRS)

Jackson, C. E., Jr.

1976-01-01

The NTA Level 15.5.2/3, was used to provide non-linear steady-state (NLSS) and non-linear transient (NLTR) thermal predictions for the International Ultraviolet Explorer (IUE) Scientific Instrument (SI). NASTRAN structural models were used as the basis for the thermal models, which were produced by a straight forward conversion procedure. The accuracy of this technique was sub-sequently demonstrated by a comparison of NTA predicts with the results of a thermal vacuum test of the IUE Engineering Test Unit (ETU). Completion of these tasks was aided by the use of NTA subroutines.

Literature Reviews on Modeling Internal Geometry of Textile Composites and Rate-Independent Continuum Damage

NASA Technical Reports Server (NTRS)

Su-Yuen, Hsu

2011-01-01

Textile composite materials have good potential for constructing composite structures where the effects of three-dimensional stresses are critical or geometric complexity is a manufacturing concern. There is a recent interest in advancing competence within Langley Research Center for modeling the degradation of mechanical properties of textile composites. In an initial effort, two critical areas are identified to pursue: (1) Construction of internal geometry of textile composites, and (2) Rate-independent continuum damage mechanics. This report documents reviews on the two subjects. Various reviewed approaches are categorized, their assumptions, methods, and progress are briefed, and then critiques are presented. Each review ends with recommended research.

Modeling nonstationarity in space and time.

PubMed

Shand, Lyndsay; Li, Bo

2017-09-01

We propose to model a spatio-temporal random field that has nonstationary covariance structure in both space and time domains by applying the concept of the dimension expansion method in Bornn et al. (2012). Simulations are conducted for both separable and nonseparable space-time covariance models, and the model is also illustrated with a streamflow dataset. Both simulation and data analyses show that modeling nonstationarity in both space and time can improve the predictive performance over stationary covariance models or models that are nonstationary in space but stationary in time. © 2017, The International Biometric Society.

Simulations of Collisional Disruption at the Catastrophic Impact Energy Threshold: Effect of the Target's Internal Structure and Diameter

NASA Astrophysics Data System (ADS)

Michel, P.; Benz, W.; Richardson, D. C.

2005-08-01

Recent simulations of asteroid break-ups, including both the fragmentation of the parent body and the gravitational interactions of the fragments, have allowed to reproduced successfully the main properties of asteroid families formed in different regimes of impact energy. Here, using the same kind of simulations, we concentrate on a single regime of impact energy, the so-called catastrophic threshold usually designated by Qcrit, which results in the escape of half of the target's mass. Considering a wide range of diameter values and two kinds of internal structures of the parent body, monolithic and pre-shattered, we analyse their potential influences on the value of Qcrit and on the collisional outcome limited here to the fragment size and ejection speed distributions, which are the main outcome properties used by collisional models to study the evolutions of the different populations of small bodies. For all the considered diameters and the two internal structures of the parent body, we confirm that the process of gravitational reaccumulation is at the origin of the largest remnant's mass. We then find that, for a given diameter of the parent body, the impact energy corresponding to the catastrophic disruption threshold is highly dependent on the internal structure of the parent body. In particular, a pre-shattered parent body containing only damaged zones but no macroscopic voids is easier to disrupt than a monolithic parent body. Other kinds of internal properties that can also characterize small bodies in real populations will be investigated in a future work.

Structural mechanics simulations

NASA Technical Reports Server (NTRS)

Biffle, Johnny H.

1992-01-01

Sandia National Laboratory has a very broad structural capability. Work has been performed in support of reentry vehicles, nuclear reactor safety, weapons systems and components, nuclear waste transport, strategic petroleum reserve, nuclear waste storage, wind and solar energy, drilling technology, and submarine programs. The analysis environment contains both commercial and internally developed software. Included are mesh generation capabilities, structural simulation codes, and visual codes for examining simulation results. To effectively simulate a wide variety of physical phenomena, a large number of constitutive models have been developed.

Evaluating Individual Students' Perceptions of Instructional Quality: An Investigation of their Factor Structure, Measurement Invariance, and Relations to Educational Outcomes

PubMed Central

Scherer, Ronny; Nilsen, Trude; Jansen, Malte

2016-01-01

Students' perceptions of instructional quality are among the most important criteria for evaluating teaching effectiveness. The present study evaluates different latent variable modeling approaches (confirmatory factor analysis, exploratory structural equation modeling, and bifactor modeling), which are used to describe these individual perceptions with respect to their factor structure, measurement invariance, and the relations to selected educational outcomes (achievement, self-concept, and motivation in mathematics). On the basis of the Programme for International Student Assessment (PISA) 2012 large-scale data sets of Australia, Canada, and the USA (N = 26,746 students), we find support for the distinction between three factors of individual students' perceptions and full measurement invariance across countries for all modeling approaches. In this regard, bifactor exploratory structural equation modeling outperformed alternative approaches with respect to model fit. Our findings reveal significant relations to the educational outcomes. This study synthesizes different modeling approaches of individual students' perceptions of instructional quality and provides insights into the nature of these perceptions from an individual differences perspective. Implications for the measurement and modeling of individually perceived instructional quality are discussed. PMID:26903917

Modelling Internal Heterogeneities in Debris-Covered Glaciers: the Potential to Link Morphology and Climate

NASA Astrophysics Data System (ADS)

Stuurman, C. M.; Holt, J.; Levy, J.

2016-12-01

On Earth and Mars, debris-covered glaciers (DCGs) often exhibit arcuate ridges transverse to the flow direction. Additionally, there exists some evidence linking internal structure (which is controlled in part by climate) in DCGs with surface microtopography. A better understanding of the relationship between englacial debris bands, compressional stresses, and debris-covered glacier microtopography will augment understanding of formational environments and mechanisms for terrestrial and martian DCGs. In order to better understand relationships between DCG surface morphology and internal debris bands, we combine field observations with finite-element modeling techniques to relate internal structure of DCGs to their surface morphologies. A geophysical survey including time-domain electromagnetic and ground-penetrating radar techniques of the Galena Creek Rock Glacier, WY was conducted over two field seasons in 2015/2016. Geomorphic analysis by surface observation and photogrammetry, including examination of a cirque-based thermokarst, was used to guide and complement geophysical sounding methods. Very clean ice below a 1 m thick layer of debris was directly observed on the walls of a 40 m diameter thermokarst pond near the accumulation zone. An englacial debris band 0.7 m thick dipping 30o intersected the wall of the pond. Transverse ridges occur at varying ridge-to-ridge wavelengths at different locations on the glacier. The GPR data supports the idea that surface ridges correlate with the intersection of debris layers and the surface. Modelling evidence is consistent with the observation of ridges at debris-layer/surface intersections, with compressional stresses buckling ice up-stream of the debris band.

Quantifying model-structure- and parameter-driven uncertainties in spring wheat phenology prediction with Bayesian analysis

DOE PAGES

Alderman, Phillip D.; Stanfill, Bryan

2016-10-06

Recent international efforts have brought renewed emphasis on the comparison of different agricultural systems models. Thus far, analysis of model-ensemble simulated results has not clearly differentiated between ensemble prediction uncertainties due to model structural differences per se and those due to parameter value uncertainties. Additionally, despite increasing use of Bayesian parameter estimation approaches with field-scale crop models, inadequate attention has been given to the full posterior distributions for estimated parameters. The objectives of this study were to quantify the impact of parameter value uncertainty on prediction uncertainty for modeling spring wheat phenology using Bayesian analysis and to assess the relativemore » contributions of model-structure-driven and parameter-value-driven uncertainty to overall prediction uncertainty. This study used a random walk Metropolis algorithm to estimate parameters for 30 spring wheat genotypes using nine phenology models based on multi-location trial data for days to heading and days to maturity. Across all cases, parameter-driven uncertainty accounted for between 19 and 52% of predictive uncertainty, while model-structure-driven uncertainty accounted for between 12 and 64%. Here, this study demonstrated the importance of quantifying both model-structure- and parameter-value-driven uncertainty when assessing overall prediction uncertainty in modeling spring wheat phenology. More generally, Bayesian parameter estimation provided a useful framework for quantifying and analyzing sources of prediction uncertainty.« less

International Space Station 2A Array Modal Analysis

NASA Technical Reports Server (NTRS)

Laible, Michael; Fitzpatrick, Kristin; Grygier, Michael

2012-01-01

On December 9th 2009, the International Space Station (ISS) 2A solar array mast experienced prolonged longeron shadowing during a Soyuz undocking. Analytical reconstruction of induced thermal and dynamic structural loads showed an exceedance of the mast buckling limit. Possible structural damage to the solar array mast could have occurred during this event. A Low fidelity video survey of the 2A mast showed no obvious damage of the mast longerons or battens. The decision was made to conduct an on-orbit dynamic test of the 2A array on December 18th, 2009. The test included thruster pluming on the array while photogrammetry data was recorded. The test was similar to other Dedicated Thruster Firings (DTFs) that were performed to measure structural frequency and damping of a solar array. Results of the DTF indicated lower frequency mast modes than model predictions, thus leading to speculation of mast damage. A detailed nonlinear analysis was performed on the 2A array model to assess possible solutions to modal differences. The setup of the parametric nonlinear trade study included the use of a detailed array model and the reduced mass and stiffness matrices of the entire ISS being applied to the array interface. The study revealed that the array attachment structure is nonlinear and thus was the source of error in the model prediction of mast modes. In addition, a detailed study was performed to determine mast mode sensitivity to mast longeron damage. This sensitivity study was performed to assess if the ISS program has sufficient instrumentation for mast damage detection.

ESTIMATION OF CARBOXYLIC ACID ESTER HYDROLYSIS RATE CONSTANTS

EPA Science Inventory

SPARC chemical reactivity models were extended to calculate hydrolysis rate constants for carboxylic acid esters from molecular structure. The energy differences between the initial state and the transition state for a molecule of interest are factored into internal and external...

Interpersonal problems across levels of the psychopathology hierarchy.

PubMed

Girard, Jeffrey M; Wright, Aidan G C; Beeney, Joseph E; Lazarus, Sophie A; Scott, Lori N; Stepp, Stephanie D; Pilkonis, Paul A

2017-11-01

We examined the relationship between psychopathology and interpersonal problems in a sample of 825 clinical and community participants. Sixteen psychiatric diagnoses and five transdiagnostic dimensions were examined in relation to self-reported interpersonal problems. The structural summary method was used with the Inventory of Interpersonal Problems Circumplex Scales to examine interpersonal problem profiles for each diagnosis and dimension. We built a structural model of mental disorders including factors corresponding to detachment (avoidant personality, social phobia, major depression), internalizing (dependent personality, borderline personality, panic disorder, posttraumatic stress, major depression), disinhibition (antisocial personality, drug dependence, alcohol dependence, borderline personality), dominance (histrionic personality, narcissistic personality, paranoid personality), and compulsivity (obsessive-compulsive personality). All dimensions showed good interpersonal prototypicality (e.g., detachment was defined by a socially avoidant/nonassertive interpersonal profile) except for internalizing, which was diffusely associated with elevated interpersonal distress. The findings for individual disorders were largely consistent with the dimension that each disorder loaded on, with the exception of the internalizing and dominance disorders, which were interpersonally heterogeneous. These results replicate previous findings and provide novel insights into social dysfunction in psychopathology by wedding the power of hierarchical (i.e., dimensional) modeling and interpersonal circumplex assessment. Copyright © 2017 Elsevier Inc. All rights reserved.

Comment on "Can assimilation of crowdsourced data in hydrological modelling improve flood prediction?" by Mazzoleni et al. (2017)

NASA Astrophysics Data System (ADS)

Viero, Daniele P.

2018-01-01

Citizen science and crowdsourcing are gaining increasing attention among hydrologists. In a recent contribution, Mazzoleni et al. (2017) investigated the integration of crowdsourced data (CSD) into hydrological models to improve the accuracy of real-time flood forecasts. The authors used synthetic CSD (i.e. not actually measured), because real CSD were not available at the time of the study. In their work, which is a proof-of-concept study, Mazzoleni et al. (2017) showed that assimilation of CSD improves the overall model performance; the impact of irregular frequency of available CSD, and that of data uncertainty, were also deeply assessed. However, the use of synthetic CSD in conjunction with (semi-)distributed hydrological models deserves further discussion. As a result of equifinality, poor model identifiability, and deficiencies in model structure, internal states of (semi-)distributed models can hardly mimic the actual states of complex systems away from calibration points. Accordingly, the use of synthetic CSD that are drawn from model internal states under best-fit conditions can lead to overestimation of the effectiveness of CSD assimilation in improving flood prediction. Operational flood forecasting, which results in decisions of high societal value, requires robust knowledge of the model behaviour and an in-depth assessment of both model structure and forcing data. Additional guidelines are given that are useful for the a priori evaluation of CSD for real-time flood forecasting and, hopefully, for planning apt design strategies for both model calibration and collection of CSD.

HIV, violence, blame and shame: pathways of risk to internalized HIV stigma among South African adolescents living with HIV.

PubMed

Pantelic, Marija; Boyes, Mark; Cluver, Lucie; Meinck, Franziska

2017-08-21

Internalized HIV stigma is a key risk factor for negative outcomes amongst adolescents living with HIV (ALHIV), including non-adherence to anti-retroviral treatment, loss-to-follow-up and morbidity. This study tested a theoretical model of multi-level risk pathways to internalized HIV stigma among South African ALHIV. From 2013 to 2015, a survey using t otal population sampling of ALHIV who had ever initiated anti-retroviral treatment (ART) in 53 public health facilities in the Eastern Cape, South Africa was conducted. Community-tracing ensured inclusion of ALHIV who were defaulting from ART or lost to follow-up. 90.1% of eligible ALHIV were interviewed ( n  = 1060, 55% female, mean age = 13.8, 21% living in rural locations). HIV stigma mechanisms (internalized, enacted, and anticipated), HIV-related disability, violence victimization (physical, emotional, sexual abuse, bullying victimization) were assessed using well-validated self-report measures. Structural equation modelling was used to test a theoretically informed model of risk pathways from HIV-related disability to internalized HIV stigma. The model controlled for age, gender and urban/rural address. Prevalence of internalized HIV stigma was 26.5%. As hypothesized, significant associations between internalized stigma and anticipated stigma, as well as depression were obtained. Unexpectedly, HIV-related disability, victimization, and enacted stigma were not directly associated with internalized stigma. Instead significant pathways were identified via anticipated HIV stigma and depression. The model fitted the data well (RMSEA = .023; CFI = .94; TLI = .95; WRMR = 1.070). These findings highlight the complicated nature of internalized HIV stigma. Whilst it is seemingly a psychological process, indirect pathways suggest multi-level mechanisms leading to internalized HIV stigma. Findings suggest that protection from violence within homes, communities and schools may interrupt risk pathways from HIV-related health problems to psychological distress and internalized HIV stigma. This highlights the potential for interventions that do not explicitly target adolescents living with HIV but are sensitive to their needs.

HIV, violence, blame and shame: pathways of risk to internalized HIV stigma among South African adolescents living with HIV

PubMed Central

Pantelic, Marija; Boyes, Mark; Cluver, Lucie; Meinck, Franziska

2017-01-01

Abstract Introduction: Internalized HIV stigma is a key risk factor for negative outcomes amongst adolescents living with HIV (ALHIV), including non-adherence to anti-retroviral treatment, loss-to-follow-up and morbidity. This study tested a theoretical model of multi-level risk pathways to internalized HIV stigma among South African ALHIV. Methods: From 2013 to 2015, a survey using total population sampling of ALHIV who had ever initiated anti-retroviral treatment (ART) in 53 public health facilities in the Eastern Cape, South Africa was conducted. Community-tracing ensured inclusion of ALHIV who were defaulting from ART or lost to follow-up. 90.1% of eligible ALHIV were interviewed (n = 1060, 55% female, mean age = 13.8, 21% living in rural locations). HIV stigma mechanisms (internalized, enacted, and anticipated), HIV-related disability, violence victimization (physical, emotional, sexual abuse, bullying victimization) were assessed using well-validated self-report measures. Structural equation modelling was used to test a theoretically informed model of risk pathways from HIV-related disability to internalized HIV stigma. The model controlled for age, gender and urban/rural address. Results: Prevalence of internalized HIV stigma was 26.5%. As hypothesized, significant associations between internalized stigma and anticipated stigma, as well as depression were obtained. Unexpectedly, HIV-related disability, victimization, and enacted stigma were not directly associated with internalized stigma. Instead significant pathways were identified via anticipated HIV stigma and depression. The model fitted the data well (RMSEA = .023; CFI = .94; TLI = .95; WRMR = 1.070). Conclusions: These findings highlight the complicated nature of internalized HIV stigma. Whilst it is seemingly a psychological process, indirect pathways suggest multi-level mechanisms leading to internalized HIV stigma. Findings suggest that protection from violence within homes, communities and schools may interrupt risk pathways from HIV-related health problems to psychological distress and internalized HIV stigma. This highlights the potential for interventions that do not explicitly target adolescents living with HIV but are sensitive to their needs. PMID:28853517

The Structure and Dynamics of the Solar Corona and Inner Heliosphere-First Quarter First Year Progress Report

NASA Technical Reports Server (NTRS)

Mikic, Zoran; Grebowsky, J. (Technical Monitor)

2000-01-01

This report details progress during the first quarter of the first year of our Sun-Earth Connections Theory Program (SECTP) contract. Science Applications International Corporation (SAIC) and the University of California, Irvine (UCI) have conducted research into theoretical modeling of active regions, the solar corona, and the inner heliosphere, using the MHD model.

Implications of the Changing Status of English for Instructional Models of English: A Study of Vietnamese ELT Teachers' Reflections

ERIC Educational Resources Information Center

Phan, Ngan Le hai

2018-01-01

English language teaching (ELT) in Vietnam has been influenced mostly by the native speaker model through the communicative language approach (Pham, 2005). With the spread of globalisation, however, English as an international language has undergone major demographic, geographic, and structural changes. The current roles and status of English…

A Method to Capture Macroslip at Bolted Interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, Ronald Neil; Heitman, Lili Anne Akin

2015-10-01

Relative motion at bolted connections can occur for large shock loads as the internal shear force in the bolted connection overcomes the frictional resistive force. This macroslip in a structure dissipates energy and reduces the response of the components above the bolted connection. There is a need to be able to capture macroslip behavior in a structural dynamics model. A linear model and many nonlinear models are not able to predict marcoslip effectively. The proposed method to capture macroslip is to use the multi-body dynamics code ADAMS to model joints with 3-D contact at the bolted interfaces. This model includesmore » both static and dynamic friction. The joints are preloaded and the pinning effect when a bolt shank impacts a through hole inside diameter is captured. Substructure representations of the components are included to account for component flexibility and dynamics. This method was applied to a simplified model of an aerospace structure and validation experiments were performed to test the adequacy of the method.« less

A Method to Capture Macroslip at Bolted Interfaces [PowerPoint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, Ronald Neil; Heitman, Lili Anne Akin

2016-01-01

Relative motion at bolted connections can occur for large shock loads as the internal shear force in the bolted connection overcomes the frictional resistive force. This macroslip in a structure dissipates energy and reduces the response of the components above the bolted connection. There is a need to be able to capture macroslip behavior in a structural dynamics model. A linear model and many nonlinear models are not able to predict marcoslip effectively. The proposed method to capture macroslip is to use the multi-body dynamics code ADAMS to model joints with 3-D contact at the bolted interfaces. This model includesmore » both static and dynamic friction. The joints are preloaded and the pinning effect when a bolt shank impacts a through hole inside diameter is captured. Substructure representations of the components are included to account for component flexibility and dynamics. This method was applied to a simplified model of an aerospace structure and validation experiments were performed to test the adequacy of the method.« less

Factors affecting smartphone adoption for accessing information in medical settings.

PubMed

Tahamtan, Iman; Pajouhanfar, Sara; Sedghi, Shahram; Azad, Mohsen; Roudbari, Masoud

2017-06-01

This study aimed to acquire knowledge about the factors affecting smartphone adoption for accessing information in medical settings in Iranian Hospitals. A qualitative and quantitative approach was used to conduct this study. Semi-structured interviews were conducted with 21 medical residents and interns in 2013 to identify determinant factors for smartphone adoption. Afterwards, nine relationships were hypothesised. We developed a questionnaire to test these hypotheses and to evaluate the importance of each factor. Structural equation modelling was used to analyse the causal relations between model parameters and to accurately identify determinant factors. Eight factors were identified in the qualitative phase of the study, including perceived usefulness, perceived ease of use, training, internal environment, personal experience, social impacts, observability and job related characteristics. Among the studied factors, perceived usefulness, personal experience and job related characteristics were significantly associated with attitude to use a smartphone which accounted for 64% of the variance in attitude. Perceived usefulness had the strongest impact on attitude to use a smartphone. The factors that emerged from interviews were consistent with the Technology Acceptance Model (TAM) and some previous studies. TAM is a reliable model for understanding the factors of smartphone acceptance in medical settings. © 2017 Health Libraries Group.

New evidence of factor structure and measurement invariance of the SDQ across five European nations.

PubMed

Ortuño-Sierra, Javier; Fonseca-Pedrero, Eduardo; Aritio-Solana, Rebeca; Velasco, Alvaro Moreno; de Luis, Edurne Chocarro; Schumann, Gunter; Cattrell, Anna; Flor, Herta; Nees, Frauke; Banaschewski, Tobias; Bokde, Arun; Whelan, Rob; Buechel, Christian; Bromberg, Uli; Conrod, Patricia; Frouin, Vincent; Papadopoulos, Dimitri; Gallinat, Juergen; Garavan, Hugh; Heinz, Andreas; Walter, Henrik; Struve, Maren; Gowland, Penny; Paus, Tomáš; Poustka, Luise; Martinot, Jean-Luc; Paillère-Martinot, Marie-Laure; Vetter, Nora C; Smolka, Michael N; Lawrence, Claire

2015-12-01

The main purpose of the present study was to analyse the internal structure and to test the measurement invariance of the Strengths and Difficulties Questionnaire (SDQ), self-reported version, in five European countries. The sample consisted of 3012 adolescents aged between 12 and 17 years (M = 14.20; SD = 0.83). The five-factor model (with correlated errors added), and the five-factor model (with correlated errors added) with the reverse-worded items allowed to cross-load on the Prosocial subscale, displayed adequate goodness of-fit indices. Multi-group confirmatory factor analysis showed that the five-factor model (with correlated errors added) had partial strong measurement invariance by countries. A total of 11 of the 25 items were non-invariant across samples. The level of internal consistency of the Total difficulties score was 0.84, ranging between 0.69 and 0.78 for the SDQ subscales. The findings indicate that the SDQ's subscales need to be modified in various ways for screening emotional and behavioural problems in the five European countries that were analysed.

The Social Anxiety and Depression Life Interference—24 Inventory: Classical and modern psychometric evaluations

PubMed Central

Berzins, Tiffany L.; Garcia, Antonio F.; Acosta, Melina; Osman, Augustine

2017-01-01

Two instrument validation studies broadened the research literature exploring the factor structure, internal consistency reliability, and concurrent validity of scores on the Social Anxiety and Depression Life Interference—24 Inventory (SADLI-24; Osman, Bagge, Freedenthal, Guiterrez, & Emmerich, 2011). Study 1 (N = 1065) was undertaken to concurrently appraise three competing factor models for the instrument: a unidimensional model, a two-factor oblique model and a bifactor model. The bifactor model provided the best fit to the study sample data. Study 2 (N = 220) extended the results from Study 1 with an investigation of the convergent and discriminant validity for the bifactor model of the SADLI-24 with multiple regression analyses and scale-level exploratory structural equation modeling. This project yields data that augments the initial instrument development investigations for the target measure. PMID:28781401

Quantitative structure-toxicity relationship (QSTR) studies on the organophosphate insecticides.

PubMed

Can, Alper

2014-11-04

Organophosphate insecticides are the most commonly used pesticides in the world. In this study, quantitative structure-toxicity relationship (QSTR) models were derived for estimating the acute oral toxicity of organophosphate insecticides to male rats. The 20 chemicals of the training set and the seven compounds of the external testing set were described by means of using descriptors. Descriptors for lipophilicity, polarity and molecular geometry, as well as quantum chemical descriptors for energy were calculated. Model development to predict toxicity of organophosphate insecticides in different matrices was carried out using multiple linear regression. The model was validated internally and externally. In the present study, QSTR model was used for the first time to understand the inherent relationships between the organophosphate insecticide molecules and their toxicity behavior. Such studies provide mechanistic insight about structure-toxicity relationship and help in the design of less toxic insecticides. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Unifying dynamical and structural stability of equilibria

NASA Astrophysics Data System (ADS)

Arnoldi, Jean-François; Haegeman, Bart

2016-09-01

We exhibit a fundamental relationship between measures of dynamical and structural stability of linear dynamical systems-e.g. linearized models in the vicinity of equilibria. We show that dynamical stability, quantified via the response to external perturbations (i.e. perturbation of dynamical variables), coincides with the minimal internal perturbation (i.e. perturbations of interactions between variables) able to render the system unstable. First, by reformulating a result of control theory, we explain that harmonic external perturbations reflect the spectral sensitivity of the Jacobian matrix at the equilibrium, with respect to constant changes of its coefficients. However, for this equivalence to hold, imaginary changes of the Jacobian's coefficients have to be allowed. The connection with dynamical stability is thus lost for real dynamical systems. We show that this issue can be avoided, thus recovering the fundamental link between dynamical and structural stability, by considering stochastic noise as external and internal perturbations. More precisely, we demonstrate that a linear system's response to white-noise perturbations directly reflects the intensity of internal white-noise disturbance that it can accommodate before becoming stochastically unstable.

International Trade Drives Global Resource Use: A Structural Decomposition Analysis of Raw Material Consumption from 1990-2010.

PubMed

Plank, Barbara; Eisenmenger, Nina; Schaffartzik, Anke; Wiedenhofer, Dominik

2018-04-03

Globalization led to an immense increase of international trade and the emergence of complex global value chains. At the same time, global resource use and pressures on the environment are increasing steadily. With these two processes in parallel, the question arises whether trade contributes positively to resource efficiency, or to the contrary is further driving resource use? In this article, the socioeconomic driving forces of increasing global raw material consumption (RMC) are investigated to assess the role of changing trade relations, extended supply chains and increasing consumption. We apply a structural decomposition analysis of changes in RMC from 1990 to 2010, utilizing the Eora multi-regional input-output (MRIO) model. We find that changes in international trade patterns significantly contributed to an increase of global RMC. Wealthy developed countries play a major role in driving global RMC growth through changes in their trade structures, as they shifted production processes increasingly to less material-efficient input suppliers. Even the dramatic increase in material consumption in the emerging economies has not diminished the role of industrialized countries as drivers of global RMC growth.

Unifying dynamical and structural stability of equilibria.

PubMed

Arnoldi, Jean-François; Haegeman, Bart

2016-09-01

We exhibit a fundamental relationship between measures of dynamical and structural stability of linear dynamical systems-e.g. linearized models in the vicinity of equilibria. We show that dynamical stability, quantified via the response to external perturbations (i.e. perturbation of dynamical variables), coincides with the minimal internal perturbation (i.e. perturbations of interactions between variables) able to render the system unstable. First, by reformulating a result of control theory, we explain that harmonic external perturbations reflect the spectral sensitivity of the Jacobian matrix at the equilibrium, with respect to constant changes of its coefficients. However, for this equivalence to hold, imaginary changes of the Jacobian's coefficients have to be allowed. The connection with dynamical stability is thus lost for real dynamical systems. We show that this issue can be avoided, thus recovering the fundamental link between dynamical and structural stability, by considering stochastic noise as external and internal perturbations. More precisely, we demonstrate that a linear system's response to white-noise perturbations directly reflects the intensity of internal white-noise disturbance that it can accommodate before becoming stochastically unstable.