Science.gov

Sample records for international study group

  1. International Study Tour Groups

    ERIC Educational Resources Information Center

    O'Reilly, Frances L.; Matt, John J.; McCaw, William P.; Kero, Patty; Stewart, Courtney; Haddouch, Reda

    2014-01-01

    Using the context of international study tour groups, this study examined the personal and professional transformation that occurred among host faculty and staff at The University of Montana-Missoula as a result of their interactions with traveling academics from other countries. Data were collected from participant responses (n = 27) using a…

  2. International Study Group Progress Report

    SciTech Connect

    Raubenheimer, Tor O

    2000-07-18

    The focus of the ISG work was on advancing the accelerator design and supporting technologies. This is a complex process which involves a close interaction between theoretical analysis of the collider design and R and D progress on hardware components. The sequence of efforts took place roughly in the following order: (1) Optimization of the collider parameters and definition of system and subsystem requirements, (2) Identification of design strategies and options, and (3) Development of specific technologies to achieve these requirements. Development and testing of the required components, and R and D on manufacturing techniques have been important activities of the ISG. Experiments at the major test facilities such as the ATF at KEK and ASSET at SLAC have also played a significant role in the ISG studies.

  3. International scoping study: accelerator working group report

    SciTech Connect

    Zisman, Michael; Zisman, M.S.

    2006-09-30

    During the past several years, an International Scoping Study (ISS) of a Neutrino Factory was carried out, with the aim of developing an internationally accepted baseline facility design. Progress toward that goal will be described. Many of the key technical aspects of a Neutrino Factory facility design are presently being investigated experimentally, and the status of these investigations will be mentioned. Plans for the recently launched International Design Study (IDS), which serves as a follow-on to the ISS, will be briefly described.

  4. International Pediatric MS Study Group Global Members Symposium report.

    PubMed

    Wassmer, Evangeline; Chitnis, Tanuja; Pohl, Daniela; Amato, Maria Pia; Banwell, Brenda; Ghezzi, Angelo; Hintzen, Rogier Q; Krupp, Lauren B; Makhani, Naila; Rostásy, Kevin; Tardieu, Marc; Tenembaum, Silvia; Waldman, Amy; Waubant, Emmanuelle; Kornberg, Andrew J

    2016-08-30

    The International Pediatric Multiple Sclerosis Study Group held its inaugural educational program, "The World of Pediatric MS: A Global Update," in September 2014 to discuss advances and challenges in the diagnosis and management of pediatric multiple sclerosis (MS) and other neuroinflammatory CNS disorders. Highlights included a discussion on the revised diagnostic criteria, which enable the differentiation of MS, acute disseminated encephalomyelitis, neuromyelitis optica, and other neuroinflammatory disorders. While these criteria currently identify clinical and MRI features for a particular diagnosis, advances in biomarkers may prove to be useful in the future. An update was also provided on environmental factors associated with pediatric MS risk and possibly outcomes, notably vitamin D deficiency. However, optimal vitamin D intake and its role in altering MS course in children have yet to be established. Regarding MS outcomes, our understanding of the cognitive consequences of early-onset MS has grown. However, further work is needed to define the course of cognitive function and its long-term outcome in diverse patient samples and to develop strategies for effective cognitive rehabilitation specifically tailored to children and adolescents. Finally, treatment strategies were discussed, including a need to consider additional drug treatment options and paradigms (escalation vs induction), although treatment should be tailored to the individual child. Of critical importance, clinical trials of newer MS agents in children are required. Although our understanding of childhood MS has improved, further research is needed to have a positive impact for children and their families. PMID:27572855

  5. International Pediatric MS Study Group Global Members Symposium report.

    PubMed

    Wassmer, Evangeline; Chitnis, Tanuja; Pohl, Daniela; Amato, Maria Pia; Banwell, Brenda; Ghezzi, Angelo; Hintzen, Rogier Q; Krupp, Lauren B; Makhani, Naila; Rostásy, Kevin; Tardieu, Marc; Tenembaum, Silvia; Waldman, Amy; Waubant, Emmanuelle; Kornberg, Andrew J

    2016-08-30

    The International Pediatric Multiple Sclerosis Study Group held its inaugural educational program, "The World of Pediatric MS: A Global Update," in September 2014 to discuss advances and challenges in the diagnosis and management of pediatric multiple sclerosis (MS) and other neuroinflammatory CNS disorders. Highlights included a discussion on the revised diagnostic criteria, which enable the differentiation of MS, acute disseminated encephalomyelitis, neuromyelitis optica, and other neuroinflammatory disorders. While these criteria currently identify clinical and MRI features for a particular diagnosis, advances in biomarkers may prove to be useful in the future. An update was also provided on environmental factors associated with pediatric MS risk and possibly outcomes, notably vitamin D deficiency. However, optimal vitamin D intake and its role in altering MS course in children have yet to be established. Regarding MS outcomes, our understanding of the cognitive consequences of early-onset MS has grown. However, further work is needed to define the course of cognitive function and its long-term outcome in diverse patient samples and to develop strategies for effective cognitive rehabilitation specifically tailored to children and adolescents. Finally, treatment strategies were discussed, including a need to consider additional drug treatment options and paradigms (escalation vs induction), although treatment should be tailored to the individual child. Of critical importance, clinical trials of newer MS agents in children are required. Although our understanding of childhood MS has improved, further research is needed to have a positive impact for children and their families.

  6. Present and future projects of the International Breast Cancer Study Group.

    PubMed

    Goldhirsch, A; Gelber, R D; Castiglione, M; Price, K N; Rudenstam, C M; Lindtner, J; Collins, J; Senn, H J; Brunner, K W; Galligioni, E

    1994-08-01

    The International Breast Cancer Study Group (formerly the Ludwig Group) has conducted nine clinical trials since 1978 (see the Appendix for participants and authors). Biologic hypotheses related to the combined use of chemotherapy and endocrine therapy in women with operable breast cancer were tested. Questions of timing of chemotherapy with respect to tumor surgery and late introduction of chemotherapy were also evaluated. Ongoing and future trials continue in this tradition to investigate combinations of available endocrine therapies and cytotoxic agents.

  7. Factors affecting baseline quality of life in two international adjuvant breast cancer trials. International Breast Cancer Study Group (IBCSG).

    PubMed Central

    Bernhard, J.; Hürny, C.; Coates, A. S.; Peterson, H. F.; Castiglione-Gertsch, M.; Gelber, R. D.; Galligioni, E.; Marini, G.; Thürlimann, B.; Forbes, J. F.; Goldhirsch, A.; Senn, H. J.; Rudenstam, C. M.

    1998-01-01

    Quality of life (QL) is used to assess treatments in clinical trials but may be influenced by other factors. We analysed the impact of biomedical, sociodemographic and cultural factors on baseline QL indicators in two International Breast Cancer Study Group trials. Patients with stage II breast cancer were randomized within 6 weeks of primary surgery to various adjuvant treatments. They were asked to assess five indicators of QL at baseline. QL forms were available for 1231 (83%) of the 1475 premenopausal and 989 (82%) of the 1212 post-menopausal patients, who were from nine countries and spoke seven languages. Culture (defined as language/country groups) had a statistically significant impact on baseline QL measures. Premenopausal patients with poor prognostic factors showed a tendency to report worse QL, with oestrogen receptor status as an independent predictor for mood (P = 0.0005). Older post-menopausal patients reported better emotional wellbeing (P = 0.002), mood (P = 0.002), and less effort to cope (P = 0.0009) compared with younger post-menopausal patients. Co-morbidity, type of surgery, treatment assignment and sociodemographic factors showed a statistically significant impact in post-menopausal patients only. Cultural and biomedical factors influenced baseline QL and should be considered when evaluating the impact of treatment on QL in international breast cancer clinical trials. PMID:9744512

  8. Microwave Study of a Hydrogen-Transfer Methyl-Group Internal Rotation in 5-METHYLTROPOLONE

    NASA Astrophysics Data System (ADS)

    Ilyushin, Vadim V.; Cloessner, Emily A.; Chou, Yung-Ching; Picraux, Laura B.; Hougen, Jon T.; Lavrich, Richard

    2010-06-01

    We present here the first experimental and theoretical study of the microwave spectrum of 5-methyltropolone, which can be visualized as a 7-membered "aromatic" carbon ring with a five-membered hydrogen-bonded cyclic structure at the top and a methyl group at the bottom. The molecule exhibits two large-amplitude motions, an intramolecular hydrogen transfer and a methyl torsion. The former motion is particularly interesting because transfer of the hydrogen atom from the hydroxyl to the carbonyl group induces a tautomerization in the molecule, which then triggers a 60° internal rotation of the methyl group. Measurements were carried out by Fourier-transform microwave spectroscopy in the 8 to 24 GHz frequency range. Theoretical analysis was carried out using a tunneling-rotational Hamiltonian based on a G12^m extended-group-theory formalism. Our global fit of 1015 transitions to 20 molecular parameters gave a root-mean-square deviation of 1.5 kHz. The tunneling splitting of the two J = 0 levels arising from a hypothetical pure hydrogen transfer motion is calculated to be 1310 MHz. The tunneling splitting of the two J = 0 levels arising from a hypothetical pure methyl-top internal rotation motion is calculated to be 885 MHz. Some theoretical difficulties in interpreting the low-order tunneling parameters in this and the related molecule 2-methylmalonaldehyde will be discussed.

  9. A focus group study of chiropractic students following international service learning experiences

    PubMed Central

    Boysen, James C.; Salsbury, Stacie A.; Derby, Dustin; Lawrence, Dana J.

    2016-01-01

    Objective: One objective of chiropractic education is to cultivate clinical confidence in novice practitioners. The purpose of this qualitative study was to describe how participation in a short-term international service learning experience changed perceptions of clinical confidence in senior chiropractic students. Methods: Seventeen senior chiropractic students participated in 4 moderated focus group sessions within 4 months after a clinical educational opportunity held in international settings. Participants answered standard questions on how this educational experience may have changed their clinical confidence. Two investigators performed qualitative thematic analysis of the verbatim transcripts to identify core concepts and supporting themes. Results: The core concept was transformation from an unsure student to a confident doctor. The service learning experience allowed students to deliver chiropractic treatment to patients in a real-world setting, engage in frequent repetitions of technical skills, perform clinical decision-making and care coordination, and communicate with patients and other health professionals. Students described increased clinical confidence in 9 competency areas organized within 3 domains: (1) chiropractic competencies including observation, palpation, and manipulation; (2) clinical competencies including problem solving, clinic flow, and decision-making; and (3) communication competencies, including patient communication, interprofessional communication, and doctor–patient relationship. Students recommended that future service learning programs include debriefing sessions similar to the experience offered by these focus groups to enhance student learning. Conclusion: Senior chiropractic students who participated in an international service learning program gained confidence and valuable practical experience in integrating their chiropractic, clinical, and communication skills for their future practices. PMID:27258817

  10. Prognostic value of Helix pomatia in breast cancer. International (Ludwig) Breast Cancer Study Group.

    PubMed Central

    1993-01-01

    Six hundred and eighty-four primary breast cancers from the International (Ludwig) Breast Cancer Study Group (IBCSG) were studied for Helix pomatia lectin (HPA) binding. There was a weak correlation between lymph node-positive and HPA positive (P = 0.04). In our series there was a large advantage in disease-free survival (DFS) and overall survival (OS) for node-negative patients (P < 0.0001 DFS and OS). However, there was no such advantage for HPA-negative patients (P = 0.23 DFS and P = 0.32 OS). We conclude that in this randomised patient group HPA is of no clinical predictive value. Images Figure 1 PMID:8318406

  11. International studies on burnup credit criticality safety by an OECD/NEA working group

    SciTech Connect

    Brady, M.C.; Okuno, H.; DeHart, M.D.; Nouri, A.; Sartori, E.

    1998-11-01

    The results and conclusions from a six-year study by an international benchmarking group in the comparison of computational methods for evaluating burnup credit in criticality safety analyses is presented. Approximately 20 participants from 12 countries have provided results for most problems. Four detailed benchmark problems for pressurized-water-reactor fuel have been completed. Results from work being finalized, addressing burnup credit for boiling-water-reactor fuel, are discussed, as well as planned activities for additional benchmarks, including mixed-oxide fuels, and other activities.

  12. Stroke in Children With Cardiac Disease: Report From the International Pediatric Stroke Study Group Symposium

    PubMed Central

    Sinclair, Adriane J.; Fox, Christine K.; Ichord, Rebecca N.; Almond, Christopher S.; Bernard, Timothy J.; Beslow, Lauren A.; Chan, Anthony K.C.; Cheung, Michael; deVeber, Gabrielle; Dowling, Michael M.; Friedman, Neil; Giglia, Therese M.; Guilliams, Kristin P.; Humpl, Tilman; Licht, Daniel J.; Mackay, Mark T.; Jordan, Lori C.

    2016-01-01

    BACKGROUND Cardiac disease is a leading cause of stroke in children, yet limited data support the current stroke prevention and treatment recommendations. A multidisciplinary panel of clinicians was convened in February 2014 by the International Pediatric Stroke Study group to identify knowledge gaps and prioritize clinical research efforts for children with cardiac disease and stroke. RESULTS Significant knowledge gaps exist, including a lack of data on stroke incidence, predictors, primary and secondary stroke prevention, hyperacute treatment, and outcome in children with cardiac disease. Commonly used diagnostic techniques including brain computed tomography and ultrasound have low rates of stroke detection, and diagnosis is frequently delayed. The challenges of research studies in this population include epidemiologic barriers to research such as small patient numbers, heterogeneity of cardiac disease, and coexistence of multiple risk factors. Based on stroke burden and study feasibility, studies involving mechanical circulatory support, single ventricle patients, early stroke detection strategies, and understanding secondary stroke risk factors and prevention are the highest research priorities over the next 5-10 years. The development of large-scale multicenter and multispecialty collaborative research is a critical next step. The designation of centers of expertise will assist in clinical care and research. CONCLUSIONS There is an urgent need for additional research to improve the quality of evidence in guideline recommendations for cardiogenic stroke in children. Although significant barriers to clinical research exist, multicenter and multispecialty collaboration is an important step toward advancing clinical care and research for children with cardiac disease and stroke. PMID:25532775

  13. A Qualitative Study of the Use of Sand for Counselor Interns in Group Supervision: A Grounded Theory Approach

    ERIC Educational Resources Information Center

    Andrade, Helena Bohn

    2009-01-01

    The purpose of this study was to explore sandtray as a group supervision method in counselor education programs. The research centered on the personal growth and development of counselor interns as they conceptualized and reflected on cases during group supervision. Research questions guiding the process included: What is the experience of…

  14. Genetic modifiers of ambulation in the cooperative international Neuromuscular research group Duchenne natural history study

    PubMed Central

    Bello, Luca; Kesari, Akanchha; Gordish-Dressman, Heather; Cnaan, Avital; Morgenroth, Lauren P; Punetha, Jaya; Duong, Tina; Henricson, Erik K; Pegoraro, Elena; McDonald, Craig M; Hoffman, Eric P

    2015-01-01

    Objective We studied the effects of LTBP4 and SPP1 polymorphisms on age at loss of ambulation (LoA) in a multiethnic Duchenne muscular dystrophy (DMD) cohort. Methods We genotyped SPP1 rs28357094 and LTBP4 haplotype in 283 of 340 participants in the Cooperative International Neuromuscular Research Group Duchenne Natural History Study (CINRG-DNHS). Median ages at LoA were compared by Kaplan–Meier analysis and log-rank test. We controlled polymorphism analyses for concurrent effects of glucocorticoid corticosteroid (GC) treatment (time-varying Cox regression) and for population stratification (multidimensional scaling of genome-wide markers). Results Hispanic and South Asian participants (n = 18, 41) lost ambulation 2.7 and 2 years earlier than Caucasian subjects (p = 0.003, <0.001). The TG/GG genotype at SPP1 rs28357094 was associated to 1.2-year-earlier median LoA (p = 0.048). This difference was greater (1.9 years, p = 0.038) in GC-treated participants, whereas no difference was observed in untreated subjects. Cox regression confirmed a significant effect of SPP1 genotype in GC-treated participants (hazard ratio = 1.61, p = 0.016). LTBP4 genotype showed a direction of association with age at LoA as previously reported, but it was not statistically significant. After controlling for population stratification, we confirmed a strong effect of LTBP4 genotype in Caucasians (2.4 years, p = 0.024). Median age at LoA with the protective LTBP4 genotype in this cohort was 15.0 years, 16.0 for those who were treated with GC. Interpretation SPP1 rs28357094 acts as a pharmacodynamic biomarker of GC response, and LTBP4 haplotype modifies age at LoA in the CINRG-DNHS cohort. Adjustment for GC treatment and population stratification appears crucial in assessing genetic modifiers in DMD. PMID:25641372

  15. A Study of International Undergraduate Students Taking Online Courses: Group and Organizational Socialization Theory and Sense of Belonging

    ERIC Educational Resources Information Center

    Adams, Jacob Lyle

    2013-01-01

    Purpose: This study sought to (1) identify and describe the experiences of international students participating in U.S. cohort- and text-based asynchronous online courses and to 2) analyze perceptions of belonging/isolation within online environments through group and organizational socialization theory. Research Methods: Data from interviews with…

  16. Renormalization group in internal space

    SciTech Connect

    Polonyi, J.; Sailer, K.

    2005-01-15

    Renormalization group in the internal space consists of the gradual change of the coupling constants. Functional evolution equations corresponding to the change of the mass or the coupling constant are presented in the framework of a scalar model. The evolution in the mass which yields the functional generalization of the Callan-Symanzik equation for the one-particle irreducible effective action is given in its renormalized, cutoff-independent form. The evolution of the coupling constant generates an evolution equation for the two-particle irreducible effective action.

  17. The International Thymic Malignancy Interest Group thymic initiative: a state-of-the-art study of thymic malignancies.

    PubMed

    Detterbeck, Frank; Korst, Robert

    2014-01-01

    Thymic malignancies are relatively rare tumors. A general lack of knowledge, misconceptions about benignancy, confusion about the definition of terms, and variability in reporting of outcomes have further hampered progress in these diseases. The International Thymic Malignancy Interest Group has emerged to counter these challenges and has brought together a worldwide multidisciplinary community determined to improve outcomes for these patients. Although the organization is young (initiated in 2010), major early accomplishments have created a foundation and infrastructure for scientific research. These include consensus definitions of terms, an unprecedented global database, development of practical clinical resources and, together with the International Association for the Study of Lung Cancer, development of proposals for the first formal stage classification of these malignant tumors. Many articles have been published or are under way, and a second phase of projects building on the early success is proceeding. The greatest accomplishment of the International Thymic Malignancy Interest Group lies in the establishment of an open culture of collaboration and the engagement of a broad group of individuals united by a common mission. It is a testament to what can be achieved, despite ongoing and inherent challenges, by determination and a collective effort.

  18. Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: results from a German diagnostic study in comparison with an international control group

    PubMed Central

    Braulke, Friederike; Platzbecker, Uwe; Müller-Thomas, Catharina; Götze, Katharina; Germing, Ulrich; Brümmendorf, Tim H.; Nolte, Florian; Hofmann, Wolf-Karsten; Giagounidis, Aristoteles A. N.; Lübbert, Michael; Greenberg, Peter L.; Bennett, John M.; Solé, Francesc; Mallo, Mar; Slovak, Marilyn L.; Ohyashiki, Kazuma; Le Beau, Michelle M.; Tüchler, Heinz; Pfeilstöcker, Michael; Nösslinger, Thomas; Hildebrandt, Barbara; Shirneshan, Katayoon; Aul, Carlo; Stauder, Reinhard; Sperr, Wolfgang R.; Valent, Peter; Fonatsch, Christa; Trümper, Lorenz; Haase, Detlef; Schanz, Julie

    2015-01-01

    International Prognostic Scoring Systems are used to determine the individual risk profile of myelodysplastic syndrome patients. For the assessment of International Prognostic Scoring Systems, an adequate chromosome banding analysis of the bone marrow is essential. Cytogenetic information is not available for a substantial number of patients (5%–20%) with dry marrow or an insufficient number of metaphase cells. For these patients, a valid risk classification is impossible. In the study presented here, the International Prognostic Scoring Systems were validated based on fluorescence in situ hybridization analyses using extended probe panels applied to cluster of differentiation 34 positive (CD34+) peripheral blood cells of 328 MDS patients of our prospective multicenter German diagnostic study and compared to chromosome banding results of 2902 previously published patients with myelodysplastic syndromes. For cytogenetic risk classification by fluorescence in situ hybridization analyses of CD34+ peripheral blood cells, the groups differed significantly for overall and leukemia-free survival by uni- and multivariate analyses without discrepancies between treated and untreated patients. Including cytogenetic data of fluorescence in situ hybridization analyses of peripheral CD34+ blood cells (instead of bone marrow banding analysis) into the complete International Prognostic Scoring System assessment, the prognostic risk groups separated significantly for overall and leukemia-free survival. Our data show that a reliable stratification to the risk groups of the International Prognostic Scoring Systems is possible from peripheral blood in patients with missing chromosome banding analysis by using a comprehensive probe panel (clinicaltrials.gov identifier:01355913). PMID:25344522

  19. Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: results from a German diagnostic study in comparison with an international control group.

    PubMed

    Braulke, Friederike; Platzbecker, Uwe; Müller-Thomas, Catharina; Götze, Katharina; Germing, Ulrich; Brümmendorf, Tim H; Nolte, Florian; Hofmann, Wolf-Karsten; Giagounidis, Aristoteles A N; Lübbert, Michael; Greenberg, Peter L; Bennett, John M; Solé, Francesc; Mallo, Mar; Slovak, Marilyn L; Ohyashiki, Kazuma; Le Beau, Michelle M; Tüchler, Heinz; Pfeilstöcker, Michael; Nösslinger, Thomas; Hildebrandt, Barbara; Shirneshan, Katayoon; Aul, Carlo; Stauder, Reinhard; Sperr, Wolfgang R; Valent, Peter; Fonatsch, Christa; Trümper, Lorenz; Haase, Detlef; Schanz, Julie

    2015-02-01

    International Prognostic Scoring Systems are used to determine the individual risk profile of myelodysplastic syndrome patients. For the assessment of International Prognostic Scoring Systems, an adequate chromosome banding analysis of the bone marrow is essential. Cytogenetic information is not available for a substantial number of patients (5%-20%) with dry marrow or an insufficient number of metaphase cells. For these patients, a valid risk classification is impossible. In the study presented here, the International Prognostic Scoring Systems were validated based on fluorescence in situ hybridization analyses using extended probe panels applied to cluster of differentiation 34 positive (CD34(+)) peripheral blood cells of 328 MDS patients of our prospective multicenter German diagnostic study and compared to chromosome banding results of 2902 previously published patients with myelodysplastic syndromes. For cytogenetic risk classification by fluorescence in situ hybridization analyses of CD34(+) peripheral blood cells, the groups differed significantly for overall and leukemia-free survival by uni- and multivariate analyses without discrepancies between treated and untreated patients. Including cytogenetic data of fluorescence in situ hybridization analyses of peripheral CD34(+) blood cells (instead of bone marrow banding analysis) into the complete International Prognostic Scoring System assessment, the prognostic risk groups separated significantly for overall and leukemia-free survival. Our data show that a reliable stratification to the risk groups of the International Prognostic Scoring Systems is possible from peripheral blood in patients with missing chromosome banding analysis by using a comprehensive probe panel (clinicaltrials.gov identifier:01355913). PMID:25344522

  20. Power Distance and Group Dynamics of an International Project Team: A Case Study

    ERIC Educational Resources Information Center

    Paulus, Trena M.; Bichelmeyer, Barbara; Malopinsky, Larissa; Pereira, Maura; Rastogi, Polly

    2005-01-01

    Project-based team activities are commonly used in higher education. Teams comprised of members from different national cultures can be faced with unique challenges during the creative process. Hofstede's (1991) cultural dimension of power distance was used to examine one such design team's intra- and inter-group interactions in a graduate-level…

  1. Sutureless Aortic Valve Replacement International Registry (SU-AVR-IR): design and rationale from the International Valvular Surgery Study Group (IVSSG)

    PubMed Central

    Phan, Kevin; Bouchard, Denis; Carrel, Thierry P.; Dapunt, Otto E.; Di Bartolomeo, Roberto; Eichstaedt, Harald C.; Fischlein, Theodor; Folliguet, Thierry; Gersak, Borut; Glauber, Mattia; Haverich, Axel; Misfeld, Martin; Oberwalder, Peter J.; Santarpino, Giuseppe; Shrestha, Malakh Lal; Solinas, Marco; Vola, Marco; Alamanni, Francesco; Albertini, Alberto; Bhatnagar, Gopal; Carrier, Michel; Clark, Stephen; Collart, Federic; Kappert, Utz; Kocher, Alfred; Meuris, Bart; Mignosa, Carmelo; Ouda, Ahmed; Pelletier, Marc; Rahmanian, Parwis Baradaran; Reineke, David; Teoh, Kevin; Troise, Giovanni; Villa, Emmanuel; Wahlers, Thorsten; Yan, Tristan D.

    2015-01-01

    Background Sutureless aortic valve replacement (SU-AVR) is an innovative approach which shortens cardiopulmonary bypass and cross-clamp durations and may facilitate minimally invasive approach. Evidence outlining its safety, efficacy, hemodynamic profile and potential complications is replete with small-volume observational studies and few comparative publications. Methods Minimally invasive aortic valve surgery and high-volume SU-AVR replacement centers were contacted for recruitment into a global collaborative coalition dedicated to sutureless valve research. A Research Steering Committee was formulated to direct research and support the mission of providing registry evidence warranted for SU-AVR. Results The International Valvular Surgery Study Group (IVSSG) was formed under the auspices of the Research Steering Committee, comprised of 36 expert valvular surgeons from 27 major centers across the globe. IVSSG Sutureless Projects currently proceeding include the Retrospective and Prospective Phases of the SU-AVR International Registry (SU-AVR-IR). Conclusions The global pooling of data by the IVSSG Sutureless Projects will provide required robust clinical evidence on the safety, efficacy and hemodynamic outcomes of SU-AVR. PMID:25870808

  2. Status and Plans for the Accelerator Working Group of the International Design Study of the Neutrino Factory

    SciTech Connect

    Berg, J. Scott

    2010-03-30

    The purpose of the International Design Study of the Neutrino Factory (IDS-NF) is to produce a design report for a neutrino factory in 2013. I report the status of the accelerator design and plans for future studies.

  3. Multicenter trial of cefpodoxime proxetil vs. amoxicillin-clavulanate in acute lower respiratory tract infections in childhood. International Study Group.

    PubMed

    Klein, M

    1995-04-01

    Acute lower respiratory tract infections in children are a worldwide public health problem, with an estimated 4 million potentially preventable deaths every year. Until recently, penicillin and related drugs were the treatment of choice for empiric therapy of paediatric lower respiratory tract infections. However, concerns over the emergence of penicillin-resistant strains of Streptococcus pneumoniae and beta-lactamase-producing strains of Haemophilus influenzae and Moraxella catarrhalis have led physicians to turn increasingly towards alternatives, such as the third generation cephalosporins. The oral extended spectrum cephalosporin cefpodoxime proxetil is highly active against the bacterial pathogens commonly associated with childhood lower respiratory tract infections. In order to evaluate its clinical efficacy in children with acute febrile lower respiratory tract infections, an international, multicenter, comparative, randomized open study was conducted in children ages 3 months to 11.5 years. Of 348 cases enrolled, 234 were randomized to cefpodoxime proxetil (8 mg/kg/day twice daily) and 114 to amoxicilin/clavanulate (amoxicillin 40 mg/kg/day 3 times a day). The duration of treatment was 10 days. Pretreatment diagnosis was pneumonia in 292 patients, bronchiolitis in 19 patients and acute bronchitis in 37 patients. Pathogens isolated from 59 cases included H. influenzae (47.5%), S. pneumoniae (23.7%), M. catarrhalis (11.9%) and Haemophilus parainfluenzae (6.8%). Clinical efficacy was evaluable in 278 children at the end of treatment when 95.2% of patients in the cefpodoxime proxetil group and 96.7% of patients in the amoxicillin/clavanulate group showed a satisfactory clinical response (cured or improved). The improvement was sustained at the follow-up visit, 10 to 20 days after completion of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Critical Issues in International Group Counseling

    ERIC Educational Resources Information Center

    Bemak, Fred; Chung, Rita Chi-Ying

    2015-01-01

    Three-quarters of the world come from collectivistic group-oriented cultures. As the world becomes more globalized it is inevitable that group counseling will be a major choice of healing and psychological intervention internationally. However, a review of scholarly articles from "The Journal for Specialists in Group Work" and…

  5. Comparison of remifentanil versus regional anaesthesia in children anaesthetised with isoflurane/nitrous oxide. International Remifentanil Paediatric Anaesthesia Study group.

    PubMed

    Prys-Roberts, C; Lerman, J; Murat, I; Taivainen, T; Lopez, T; Lejus, C; Spahr-Schopfer, I; Splinter, W; Kirkham, A J

    2000-09-01

    We compared the efficacy and safety of a remifentanil (0.25 microg x kg(-1) x min(-1)-based balanced anaesthetic technique with a bupivacaine-based regional anaesthetic technique in an open label, multicentre study in 271 ASA physical status 1 or 2 children aged 1-12 years. Subjects requiring major intra-abdominal, urological or orthopaedic surgery were randomly allocated to receive either intravenous remifentanil (group R; n = 185) or epidural bupivacaine (group B; n = 86) with isoflurane/nitrous oxide for their anaesthesia. The majority of children in both groups (85% in group R, 78% in group B) showed no defined response to skin incision, and although the mean increase in systolic blood pressure (+11 mm Hg) was significantly greater in group R than in group B, this change did not represent a serious haemodynamic disturbance. More children in group R (31%) required interventions to treat hypotension and/or bradycardia than those in group B (12%), but these were easily managed by administration of fluids or anticholinergic drugs. Adverse events, mainly nausea and/or vomiting, occurred in 45% of group R and 42% of group B (NS). The adverse event profile of remifentanil in this study was typical of a potent mu-opioid receptor agonist. Remifentanil was as effective as epidural or caudal block in providing analgesia and suppressing physiological responses to surgical stimuli in children aged between 1 and 12 years undergoing major abdominal, urological, or orthopaedic surgery under isoflurane/nitrous oxide anaesthesia.

  6. Comparison of remifentanil versus regional anaesthesia in children anaesthetised with isoflurane/nitrous oxide. International Remifentanil Paediatric Anaesthesia Study group.

    PubMed

    Prys-Roberts, C; Lerman, J; Murat, I; Taivainen, T; Lopez, T; Lejus, C; Spahr-Schopfer, I; Splinter, W; Kirkham, A J

    2000-09-01

    We compared the efficacy and safety of a remifentanil (0.25 microg x kg(-1) x min(-1)-based balanced anaesthetic technique with a bupivacaine-based regional anaesthetic technique in an open label, multicentre study in 271 ASA physical status 1 or 2 children aged 1-12 years. Subjects requiring major intra-abdominal, urological or orthopaedic surgery were randomly allocated to receive either intravenous remifentanil (group R; n = 185) or epidural bupivacaine (group B; n = 86) with isoflurane/nitrous oxide for their anaesthesia. The majority of children in both groups (85% in group R, 78% in group B) showed no defined response to skin incision, and although the mean increase in systolic blood pressure (+11 mm Hg) was significantly greater in group R than in group B, this change did not represent a serious haemodynamic disturbance. More children in group R (31%) required interventions to treat hypotension and/or bradycardia than those in group B (12%), but these were easily managed by administration of fluids or anticholinergic drugs. Adverse events, mainly nausea and/or vomiting, occurred in 45% of group R and 42% of group B (NS). The adverse event profile of remifentanil in this study was typical of a potent mu-opioid receptor agonist. Remifentanil was as effective as epidural or caudal block in providing analgesia and suppressing physiological responses to surgical stimuli in children aged between 1 and 12 years undergoing major abdominal, urological, or orthopaedic surgery under isoflurane/nitrous oxide anaesthesia. PMID:10947750

  7. Parenting, identity development, internalizing symptoms, and alcohol use: a cross-sectional study in a group of Italian adolescents

    PubMed Central

    Pellerone, Monica; Tolini, Giacomo; Polopoli, Caterina

    2016-01-01

    Background Literature has demonstrated the adaptive function of identity development and parenting toward manifestation of problem behaviors in adolescence. These dimensions act on both internalizing and externalizing symptoms. Methods The objective is to investigate the relationship between identity status, parenting, and adolescent problems, which may manifest through internalized (phobias, obsessions, depression, eating disorders, entropy) and externalized modes (alcohol use and school discomfort). The research involved 198 Italian students (104 males and 94 females) in the 4th year (mean =16.94 years, standard deviation =0.35) and 5th year (mean =17.94 years, standard deviation =0.43) of senior secondary schools, who live in Caltanissetta, a town located in Sicily, Italy. The research lasted for 1 school year. The general group consisted of 225 students with a mortality rate of 12%. They completed an anamnestic questionnaire to provide 1) basic information, 2) alcohol consumption attitude in the past 30 days, and 3) their beliefs about alcohol; the “Ego Identity Process Questionnaire” to investigate identity development; the “Parental Bonding Instrument” to measure the perception of parenting during childhood; and the “Constraints of Mind” to value the presence of internalizing symptoms. Results Data show that identity status influences alcohol consumption. Low-profile identity and excessive maternal control affect the relational dependence and the tendency to perfectionism in adolescents. Among the predictors of alcohol use, there are socioeconomic status, parental control, and the presence of internalizing symptoms. Conclusion Family is the favored context of learning beliefs, patterns, and values that affect the broader regulatory social environment, and for this reason, it is considered the privileged context on which to intervene to reduce the adolescents’ behavior problems. This deviance could be an external manifestation of the difficulty

  8. Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013

    PubMed Central

    Bukreyev, Alexander A.; Chandran, Kartik; Dolnik, Olga; Dye, John M.; Ebihara, Hideki; Leroy, Eric M.; Mühlberger, Elke; Netesov, Sergey V.; Patterson, Jean L.; Paweska, Janusz T.; Saphire, Erica Ollmann; Smither, Sophie J.; Takada, Ayato; Towner, Jonathan S.; Volchkov, Viktor E.; Warren, Travis K.; Kuhn, Jens H.

    2013-01-01

    The International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group prepares proposals on the classification and nomenclature of filoviruses to reflect current knowledge or to correct disagreements with the International Code of Virus Classification and Nomenclature (ICVCN). In recent years, filovirus taxonomy has been corrected and updated, but parts of it remain controversial, and several topics remain to be debated. This article summarizes the decisions and discussion of the currently acting ICTV Filoviridae Study Group since its inauguration in January 2012. PMID:24122154

  9. International Group Heterogeneity and Students' Business Project Achievement

    ERIC Educational Resources Information Center

    Ding, Ning; Bosker, Roel J.; Xu, Xiaoyan; Rugers, Lucie; van Heugten, Petra PAM

    2015-01-01

    In business higher education, group project work plays an essential role. The purpose of the present study is to explore the relationship between the group heterogeneity of students' business project groups and their academic achievements at both group and individual levels. The sample consists of 536 freshmen from an International Business School…

  10. Impact of International Foundations on the Internationalization of Chinese Research Universities: A Case Study of Peking University and the Nippon Foundation Group

    ERIC Educational Resources Information Center

    Yu, Zhan

    2010-01-01

    This study investigates two cooperative programs made by Peking University, a leading Chinese research university and the Nippon Foundation Group, an international foundation based in Japan. It attempts to examine the process through which the University collaborates with the Foundation, and explore to what extent the cooperation influenced the…

  11. Introduction of International Microgravity Strategic Planning Group

    NASA Technical Reports Server (NTRS)

    Rhome, Robert

    1998-01-01

    Established in May 6, 1995, the purpose of this International Strategic Planning Group for Microgravity Science and Applications Research is to develop and update, at least on a biennial basis, an International Strategic Plan for Microgravity Science and Applications Research. The member space agencies have agreed to contribute to the development of a Strategic Plan, and seek the implementation of the cooperative programs defined in this Plan. The emphasis of this plan is the coordination of hardware construction and utilization within the various areas of research including biotechnology, combustion science, fluid physics, materials science and other special topics in physical sciences. The Microgravity Science and Applications International Strategic Plan is a joint effort by the present members - ASI, CNES, CSA, DLR, ESA, NASA, and NASDA. It represents the consensus from a series of discussions held within the International Microgravity Strategic Planning Group (IMSPG). In 1996 several space agencies initiated multilateral discussions on how to improve the effectiveness of international microgravity research during the upcoming Space Station era. These discussions led to a recognition of the need for a comprehensive strategic plan for international microgravity research that would provide a framework for cooperation between international agencies. The Strategic Plan is intended to provide a basis for inter-agency coordination and cooperation in microgravity research in the environment of the International Space Station (ISS) era. This will be accomplished through analysis of the interests and goals of each participating agency and identification of mutual interests and program compatibilities. The Plan provides a framework for maximizing the productivity of space-based research for the benefit of our societies.

  12. International Solar Cycle Studies (ISCS), "Solar Energy Flux Study: from the interior to the outer layer" — Working Group 1 report

    NASA Astrophysics Data System (ADS)

    Pap, Judit; Fröhlich, Claus

    The purpose of this report is to describe the research activities and plans of Working Group 1: "Solar Energy Flux Study: From the Interior to the Outer Layer" of the International Solar Cycle Study (ISCS), which is an international research organization operating under the auspices of the Scientific Committee on Solar-Terrestrial Physics (SCOSTEP). As part of the report, we also summarize the status of the measurements and results on the solar energy flux variations. The main objective of ISCS's Working Group 1 is to coordinate and support comprehensive international research of the variations in the solar energy flux during the rising portion and maximum of solar cycle 23. The research activities of ISCS's Working Group 1 will concentrate on the following tasks: (1) to measure and study the variations in the solar radiative and mass output and solar activity indices during the solar activity cycle, (2) to understand why the solar radiative and mass output and the solar activity indices vary during the solar cycle, and (3) to study the role of solar variability in solar-terrestrial changes and its contribution to global change. ISCS WG1 "Solar Energy Flux Study: From the Interior to the Outer Layer" has been divided into three panels: •| Panel 1: Variations in Total and Spectral Irradiance from Infrared to Far UV. Panel leaders: Martin Anklin of the Physikalisch-Meteorologishes Observatorium Davos, Switzerland (total irradiance), Gerard Thuillier of the Service d'Aeronomie-CNRS, Verrieres, France (visible and infrared), and Linton Floyd of the Naval Research Laboratory, Washington, DC, USA (ultraviolet). •| Panel 2: Variations in EUV, X-ray and Particle Fluxes. Panel leaders: Gerhard Schmidtke of Fraunhofer IPM, Freiburg, Germany and W. Kent Tobiska of FDC/Jet Propulsion Laboratory, Pasadena, CA, USA (EUV/XUV), and David Winningham of the Southwest Research Institute, San Antonio, TX, USA (particles). •| Panel 3: Solar Indices, Cosmogenic Isotopes, Solar

  13. The International Space Life Sciences Working Group.

    PubMed

    Vernikos, J; Ahlf, P R

    1998-07-01

    The International Space Life Sciences Working Group (ISLSWG) is made up of representatives from five space agencies: the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), the Canadian Space Agency (CSA), the Centre National d'Etudes Spatiale (CNES), the Deutsches Zentrum fur Luft- und Raumfahrt (DLR, formerly the Deutsche Agentur fur Raumfahrtangelegenheiten or DARA), and the National Space Development Agency of Japan (NASDA). The group met for the first time in 1989, and since that time has developed a Strategic Plan and has taken concrete steps to implement this plan. The result is a closely coordinated international program of Space Life Sciences which will enable optimal utilization of space flight opportunities.

  14. International Space Station Earth Observations Working Group

    NASA Technical Reports Server (NTRS)

    Stefanov, William L.; Oikawa, Koki

    2015-01-01

    The multilateral Earth Observations Working Group (EOWG) was chartered in May 2012 in order to improve coordination and collaboration of Earth observing payloads, research, and applications on the International Space Station (ISS). The EOWG derives its authority from the ISS Program Science Forum, and a NASA representative serves as a permanent co-chair. A rotating co-chair position can be occupied by any of the international partners, following concurrence by the other partners; a JAXA representative is the current co-chair. Primary functions of the EOWG include, 1) the exchange of information on plans for payloads, from science and application objectives to instrument development, data collection, distribution and research; 2) recognition and facilitation of opportunities for international collaboration in order to optimize benefits from different instruments; and 3) provide a formal ISS Program interface for collection and application of remotely sensed data collected in response to natural disasters through the International Charter, Space and Major Disasters. Recent examples of EOWG activities include coordination of bilateral data sharing protocols between NASA and TsNIIMash for use of crew time and instruments in support of ATV5 reentry imaging activities; discussion of continued use and support of the Nightpod camera mount system by NASA and ESA; and review and revision of international partner contributions on Earth observations to the ISS Program Benefits to Humanity publication.

  15. 36Cl measurements in Hiroshima granite samples as part of an international intercomparison study. Results from the Munich group.

    PubMed

    Huber, T; Rühm, W; Hoshi, M; Egbert, S D; Nolte, E

    2003-04-01

    Within the effort to resolve the so-called Hiroshima neutron discrepancy, an international intercomparison study has been carried out on granite samples from Hiroshima, with participating institutions from Japan, the US, and Germany. (36)Cl and (152)Eu produced in these samples by thermal neutrons from the A-bomb explosion were assessed independently by means of different techniques. At the Maier-Leibnitz-Laboratory near Munich, Germany, (36)Cl concentrations were measured by accelerator mass spectrometry. Measured (36)Cl/Cl ratios ranged from 1,670 x 10(-13) (at a distance of 146 m from the hypocenter) to 2.2 x 10(-13) (at a distance of 1,163 m from the hypocenter). One granite sample not exposed to A-bomb neutrons was measured as a control, and a (36)Cl/Cl ratio of 2.6 x 10(-13) was obtained. On average, our experimental results are 20-30% lower than those provided by model calculations based on the dosimetry system DS86. The results presented here do not support previous assessments of (36)Cl, (60)Co, and (152)Eu which had suggested much larger thermal neutron fluences than those calculated on the basis of DS86 for distances from the hypocenter of more than 1,000 m.

  16. Synthesis of functionalized Pluronic-b-poly(ε-caprolactone) and the comparative study of their pendant groups on the cellular internalization behavior.

    PubMed

    Du, Zhengzhen; Zhang, Yan; Lang, Meidong

    2015-04-01

    This study focuses on the synthesis of Pluronic-b-poly(ε-caprolactone) bearing benzyl-oxycarbonylmethyl and carboxylic groups and the comparative study to investigate the influence of the different pendant groups on the cellular behavior. The functionalized Pluronic-b-poly(ε-caprolactone) bearing two kinds of pendant groups are synthesized via ring-opening polymerization of ε-caprolactone and 6-(benzyl-oxycarbonyl methyl)-ε-caprolactone and followed by deprotection respectively. The structure of the copolymers is confirmed and the polymeric micelles are formed by an emulsion/solvent evaporation technique. The critical micelle concentrations are improved compared with Pluronic F127, the morphologies of the micelles are spherical with the diameter on nano scale and good colloidal stability. The copolymers have good cytocompatibility and the comparative study reveals that cellular internalization, digesting by lysosome and intracellular distribution are affected by the pendant groups, moreover, the endocytosis pathway is determined by the pendant groups. Therefore, the definite internalization mechanism is beneficial for the design of polymeric micellar carriers to achieve intra- or extracellular modes of drug delivery and provide better access to either cell membrane or intracellular organelles.

  17. Nineteenth International Microgravity Measurements Group Meeting

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard (Compiler)

    2000-01-01

    The Microgravity Measurements Group meetings provide a forum for an exchange of information and ideas about various aspects of microgravity acceleration research in international microgravity research programs. These meetings are sponsored by the PI Microgravity Services (PIMS) project at the NASA Glenn Research Center. The 19th MGMG meeting was held 11-13 July 2000 at the Sheraton Airport Hotel in Cleveland, Ohio. The 44 attendees represented NASA, other space agencies, universities, and commercial companies; 8 of the attendees were international representatives from Japan, Italy, Canada, Russia, and Germany. Twenty-seven presentations were made on a variety of microgravity environment topics including the International Space Station (ISS), acceleration measurement and analysis results, science effects from microgravity accelerations, vibration isolation, free flyer satellites, ground testing, vehicle characterization, and microgravity outreach and education. The meeting participants also toured three microgravity-related facilities at the NASA Glenn Research Center. Contained within the minutes is the conference agenda, which indicates each speaker, the title of their presentation, and the actual time of their presentation. The minutes also include the charts for each presentation, which indicate the authors' name(s) and affiliation. In some cases, a separate written report was submitted and has been Included here

  18. Efficacy and safety of Stealth liposomal doxorubicin in AIDS-related Kaposi's sarcoma. The International SL-DOX Study Group.

    PubMed Central

    Goebel, F. D.; Goldstein, D.; Goos, M.; Jablonowski, H.; Stewart, J. S.

    1996-01-01

    The utility of current chemotherapeutic regimens in the treatment of AIDS-related Kaposi's sarcoma (AIDS-KS) is often compromised by both limited efficacy and substantial toxicity. Pegylated (Stealth) liposomal doxorubicin hydrochloride (SL-DOX) has been demonstrated specifically to deliver high concentrations of doxorubicin to Kaposi's sarcoma (KS) lesions. This phase II study was performed to evaluate the efficacy and safety of SL-DOX in the treatment of moderate to severe AIDS-KS. Patients were treated biweekly with 10, 20, or 40 mg m-2 SL-DOX. Tumour response was assessed according to AIDS Clinical Trials Groups (ACTG) criteria before each cycle. Best response was determined for 238 patients and was achieved after a mean of 2.3 cycles (range 1-20). Fifteen patients (6.3%) had a complete response to SL-DOX, 177 (74.4%) had a partial response, 44 (18.5%) had stable disease and two (0.8%) had disease progression. SL-DOX was well tolerated: ten patients discontinued therapy because of adverse events, in four cases because of neutropenia. Grade 3 or 4 neutropenia occurred after 281 of 2023 cycles (13.9%) but involved 137 of 240 patients (57.1%) for whom data were available. SL-DOX has substantial activity in AIDS-KS. Best response is typically seen after fewer than three cycles of chemotherapy and in some cases may be prolonged. The most important adverse event is neutropenia, which occurs after a minority of cycles but which may occur in over half of all patients. PMID:8611437

  19. NASA's Internal Space Weather Working Group

    NASA Technical Reports Server (NTRS)

    St. Cyr, O. C.; Guhathakurta, M.; Bell, H.; Niemeyer, L.; Allen, J.

    2011-01-01

    Measurements from many of NASA's scientific spacecraft are used routinely by space weather forecasters, both in the U.S. and internationally. ACE, SOHO (an ESA/NASA collaboration), STEREO, and SDO provide images and in situ measurements that are assimilated into models and cited in alerts and warnings. A number of years ago, the Space Weather laboratory was established at NASA-Goddard, along with the Community Coordinated Modeling Center. Within that organization, a space weather service center has begun issuing alerts for NASA's operational users. NASA's operational user community includes flight operations for human and robotic explorers; atmospheric drag concerns for low-Earth orbit; interplanetary navigation and communication; and the fleet of unmanned aerial vehicles, high altitude aircraft, and launch vehicles. Over the past three years we have identified internal stakeholders within NASA and formed a Working Group to better coordinate their expertise and their needs. In this presentation we will describe this activity and some of the challenges in forming a diverse working group.

  20. Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group.

    PubMed

    Denkert, Carsten; Wienert, Stephan; Poterie, Audrey; Loibl, Sibylle; Budczies, Jan; Badve, Sunil; Bago-Horvath, Zsuzsanna; Bane, Anita; Bedri, Shahinaz; Brock, Jane; Chmielik, Ewa; Christgen, Matthias; Colpaert, Cecile; Demaria, Sandra; Van den Eynden, Gert; Floris, Giuseppe; Fox, Stephen B; Gao, Dongxia; Ingold Heppner, Barbara; Kim, S Rim; Kos, Zuzana; Kreipe, Hans H; Lakhani, Sunil R; Penault-Llorca, Frederique; Pruneri, Giancarlo; Radosevic-Robin, Nina; Rimm, David L; Schnitt, Stuart J; Sinn, Bruno V; Sinn, Peter; Sirtaine, Nicolas; O'Toole, Sandra A; Viale, Giuseppe; Van de Vijver, Koen; de Wind, Roland; von Minckwitz, Gunter; Klauschen, Frederick; Untch, Michael; Fasching, Peter A; Reimer, Toralf; Willard-Gallo, Karen; Michiels, Stefan; Loi, Sherene; Salgado, Roberto

    2016-10-01

    Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are prognostic in breast cancer with potential relevance for response to immune-checkpoint inhibitor therapy. Although many groups are currently evaluating TIL, there is no standardized system for diagnostic applications. This study reports the results of two ring studies investigating TIL conducted by the International Working Group on Immuno-oncology Biomarkers. The study aim was to determine the intraclass correlation coefficient (ICC) for evaluation of TIL by different pathologists. A total of 120 slides were evaluated by a large group of pathologists with a web-based system in ring study 1 and a more advanced software-system in ring study 2 that included an integrated feedback with standardized reference images. The predefined aim for successful ring studies 1 and 2 was an ICC above 0.7 (lower limit of 95% confidence interval (CI)). In ring study 1 the prespecified endpoint was not reached (ICC: 0.70; 95% CI: 0.62-0.78). On the basis of an analysis of sources of variation, we developed a more advanced digital image evaluation system for ring study 2, which improved the ICC to 0.89 (95% CI: 0.85-0.92). The Fleiss' kappa value for <60 vs ≥60% TIL improved from 0.45 (ring study 1) to 0.63 in RS2 and the mean concordance improved from 88 to 92%. This large international standardization project shows that reproducible evaluation of TIL is feasible in breast cancer. This opens the way for standardized reporting of tumor immunological parameters in clinical studies and diagnostic practice. The software-guided image evaluation approach used in ring study 2 may be of value as a tool for evaluation of TIL in clinical trials and diagnostic practice. The experience gained from this approach might be applicable to the standardization of other diagnostic parameters in histopathology. PMID:27363491

  1. Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group.

    PubMed

    Denkert, Carsten; Wienert, Stephan; Poterie, Audrey; Loibl, Sibylle; Budczies, Jan; Badve, Sunil; Bago-Horvath, Zsuzsanna; Bane, Anita; Bedri, Shahinaz; Brock, Jane; Chmielik, Ewa; Christgen, Matthias; Colpaert, Cecile; Demaria, Sandra; Van den Eynden, Gert; Floris, Giuseppe; Fox, Stephen B; Gao, Dongxia; Ingold Heppner, Barbara; Kim, S Rim; Kos, Zuzana; Kreipe, Hans H; Lakhani, Sunil R; Penault-Llorca, Frederique; Pruneri, Giancarlo; Radosevic-Robin, Nina; Rimm, David L; Schnitt, Stuart J; Sinn, Bruno V; Sinn, Peter; Sirtaine, Nicolas; O'Toole, Sandra A; Viale, Giuseppe; Van de Vijver, Koen; de Wind, Roland; von Minckwitz, Gunter; Klauschen, Frederick; Untch, Michael; Fasching, Peter A; Reimer, Toralf; Willard-Gallo, Karen; Michiels, Stefan; Loi, Sherene; Salgado, Roberto

    2016-10-01

    Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are prognostic in breast cancer with potential relevance for response to immune-checkpoint inhibitor therapy. Although many groups are currently evaluating TIL, there is no standardized system for diagnostic applications. This study reports the results of two ring studies investigating TIL conducted by the International Working Group on Immuno-oncology Biomarkers. The study aim was to determine the intraclass correlation coefficient (ICC) for evaluation of TIL by different pathologists. A total of 120 slides were evaluated by a large group of pathologists with a web-based system in ring study 1 and a more advanced software-system in ring study 2 that included an integrated feedback with standardized reference images. The predefined aim for successful ring studies 1 and 2 was an ICC above 0.7 (lower limit of 95% confidence interval (CI)). In ring study 1 the prespecified endpoint was not reached (ICC: 0.70; 95% CI: 0.62-0.78). On the basis of an analysis of sources of variation, we developed a more advanced digital image evaluation system for ring study 2, which improved the ICC to 0.89 (95% CI: 0.85-0.92). The Fleiss' kappa value for <60 vs ≥60% TIL improved from 0.45 (ring study 1) to 0.63 in RS2 and the mean concordance improved from 88 to 92%. This large international standardization project shows that reproducible evaluation of TIL is feasible in breast cancer. This opens the way for standardized reporting of tumor immunological parameters in clinical studies and diagnostic practice. The software-guided image evaluation approach used in ring study 2 may be of value as a tool for evaluation of TIL in clinical trials and diagnostic practice. The experience gained from this approach might be applicable to the standardization of other diagnostic parameters in histopathology.

  2. 75 FR 22674 - U.S. Department of State Advisory Committee on Private International Law Study Group Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... Transactions and Its Treatment of Security Rights in Intellectual Property (IP) The Department of State, Office... work in UNCITRAL on an IP licensing guide. The meeting will take place on Friday, May 14, 2010 from 10... Group, February 8-12, 2010, in New York (A/CN.9/689), as well as the draft text of the IP supplement...

  3. 17th International Microgravity Measurements Group Meeting

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard

    1998-01-01

    The Seventeenth International Microgravity Measurements Group (MGMG) meeting was held 24-26 March 1998 at the Ohio Aerospace Institute (OAI) in Brook Park, Ohio. This meeting focused on the transition of microgravity science research from the Shuttle, Mir, and free flyers to the International Space Station. The MGMG series of meetings are conducted by the Principal Investigator Microgravity Services project of the Microgravity Science Division at the NASA Lewis Research Center. The MGMG meetings provide a forum for the exchange of information and ideas about the microgravity environment and microgravity acceleration research in the Microgravity Research Program. The meeting had participation from investigators in all areas of microgravity research. The attendees included representatives from: NASA centers; National Space Development Agency of Japan; European Space Agency; Daimler Benz Aerospace AG; Deutsches Zentrum fuer Luft- und Raumfahrt; Centre National d'Etudes Spatiales; Canadian Space Agency, national research institutions; Universities in U.S., Italy, Germany, and Russia; and commercial companies in the U.S. and Russia. Several agencies presented summaries of the measurement, analysis, and characterization of the microgravity environment of the Shuttle, Mir, and sounding rockets over the past fifteen years. This extensive effort has laid a foundation for pursuing a similar course during future microgravity science experiment operations on the ISS. Future activities of microgravity environment characterization were discussed by several agencies who plan to operate on the ISS.

  4. International neurocognitive normative study: neurocognitive comparison data in diverse resource-limited settings: AIDS Clinical Trials Group A5271.

    PubMed

    Robertson, K; Jiang, H; Evans, S R; Marra, C M; Berzins, B; Hakim, J; Sacktor, N; Silva, M Tulius; Campbell, T B; Nair, A; Schouten, J; Kumwenda, J; Supparatpinyo, K; Tripathy, S; Kumarasamy, N; la Rosa, A; Montano, S; Mwafongo, A; Firnhaber, C; Sanne, I; Naini, L; Amod, F; Walawander, A

    2016-08-01

    Infrastructure for conducting neurological research in resource-limited settings (RLS) is limited. The lack of neurological and neuropsychological (NP) assessment and normative data needed for clinical interpretation impedes research and clinical care. Here, we report on ACTG 5271, which provided neurological training of clinical site personnel and collected neurocognitive normative comparison data in diverse settings. At ten sites in seven RLS countries, we provided training for NP assessments. We collected normative comparison data on HIV- participants from Brazil (n = 240), India (n = 480), Malawi (n = 481), Peru (n = 239), South Africa (480), Thailand (n = 240), and Zimbabwe (n = 240). Participants had a negative HIV test within 30 days before standardized NP exams were administered at baseline and 770 at 6 months. Participants were enrolled in eight strata, gender (female and male), education (<10 and ≥10 years), and age (<35 and ≥35 years). Of 2400 enrolled, 770 completed the 6-month follow-up. As expected, significant between-country differences were evident in all the neurocognitive test scores (p < 0.0001). There was variation between the age, gender, and education strata on the neurocognitive tests. Age and education were important variables for all tests; older participants had poorer performance, and those with higher education had better performance. Women had better performance on verbal learning/memory and speed of processing tests, while men performed better on motor tests. This study provides the necessary neurocognitive normative data needed to build infrastructure for future neurological and neurocognitive studies in diverse RLS. These normative data are a much-needed resource for both clinicians and researchers. PMID:26733457

  5. International neurocognitive normative study: neurocognitive comparison data in diverse resource-limited settings: AIDS Clinical Trials Group A5271.

    PubMed

    Robertson, K; Jiang, H; Evans, S R; Marra, C M; Berzins, B; Hakim, J; Sacktor, N; Silva, M Tulius; Campbell, T B; Nair, A; Schouten, J; Kumwenda, J; Supparatpinyo, K; Tripathy, S; Kumarasamy, N; la Rosa, A; Montano, S; Mwafongo, A; Firnhaber, C; Sanne, I; Naini, L; Amod, F; Walawander, A

    2016-08-01

    Infrastructure for conducting neurological research in resource-limited settings (RLS) is limited. The lack of neurological and neuropsychological (NP) assessment and normative data needed for clinical interpretation impedes research and clinical care. Here, we report on ACTG 5271, which provided neurological training of clinical site personnel and collected neurocognitive normative comparison data in diverse settings. At ten sites in seven RLS countries, we provided training for NP assessments. We collected normative comparison data on HIV- participants from Brazil (n = 240), India (n = 480), Malawi (n = 481), Peru (n = 239), South Africa (480), Thailand (n = 240), and Zimbabwe (n = 240). Participants had a negative HIV test within 30 days before standardized NP exams were administered at baseline and 770 at 6 months. Participants were enrolled in eight strata, gender (female and male), education (<10 and ≥10 years), and age (<35 and ≥35 years). Of 2400 enrolled, 770 completed the 6-month follow-up. As expected, significant between-country differences were evident in all the neurocognitive test scores (p < 0.0001). There was variation between the age, gender, and education strata on the neurocognitive tests. Age and education were important variables for all tests; older participants had poorer performance, and those with higher education had better performance. Women had better performance on verbal learning/memory and speed of processing tests, while men performed better on motor tests. This study provides the necessary neurocognitive normative data needed to build infrastructure for future neurological and neurocognitive studies in diverse RLS. These normative data are a much-needed resource for both clinicians and researchers.

  6. Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study

    PubMed Central

    Jenum, Anne K; Mørkrid, Kjersti; Sletner, Line; Vange, Siri; Torper, Johan L; Nakstad, Britt; Voldner, Nanna; Rognerud-Jensen, Odd H; Berntsen, Sveinung; Mosdøl, Annhild; Skrivarhaug, Torild; Vårdal, Mari H; Holme, Ingar; Yajnik, Chittaranjan S; Birkeland, Kåre I

    2012-01-01

    Objective The International Association of Diabetes and Pregnancy Study Groups (IADPSG) recently proposed new criteria for diagnosing gestational diabetes mellitus (GDM). We compared prevalence rates, risk factors, and the effect of ethnicity using the World Health Organization (WHO) and modified IADPSG criteria. Methods This was a population-based cohort study of 823 (74% of eligible) healthy pregnant women, of whom 59% were from ethnic minorities. Universal screening was performed at 28±2 weeks of gestation with the 75 g oral glucose tolerance test (OGTT). Venous plasma glucose (PG) was measured on site. GDM was diagnosed as per the definition of WHO criteria as fasting PG (FPG) ≥7.0 or 2-h PG ≥7.8 mmol/l; and as per the modified IADPSG criteria as FPG ≥5.1 or 2-h PG ≥8.5 mmol/l. Results OGTT was performed in 759 women. Crude GDM prevalence was 13.0% with WHO (Western Europeans 11%, ethnic minorities 15%, P=0.14) and 31.5% with modified IADPSG criteria (Western Europeans 24%, ethnic minorities 37%, P< 0.001). Using the WHO criteria, ethnic minority origin was an independent predictor (South Asians, odds ratio (OR) 2.24 (95% confidence interval (CI) 1.26–3.97); Middle Easterners, OR 2.13 (1.12–4.08)) after adjustments for age, parity, and prepregnant body mass index (BMI). This increased OR was unapparent after further adjustments for body height (proxy for early life socioeconomic status), education and family history of diabetes. Using the modified IADPSG criteria, prepregnant BMI (1.09 (1.05–1.13)) and ethnic minority origin (South Asians, 2.54 (1.56–4.13)) were independent predictors, while education, body height and family history had little impact. Conclusion GDM prevalence was overall 2.4-times higher with the modified IADPSG criteria compared with the WHO criteria. The new criteria identified many subjects with a relatively mild increase in FPG, strongly associated with South Asian origin and prepregnant overweight. PMID:22108914

  7. Asian international students' barriers to joining group counseling.

    PubMed

    Lee, Ji-Yeon

    2014-10-01

    This cross-sectional study examined anticipated reactions to group participation among Asian international students (ISs). Structural equation modeling confirmed that Asian ISs' (n = 180) level of acculturation was associated with their attitude toward joining group counseling, which is partially mediated by their stigma toward help-seeking. The results of multiple regression analyses indicated that ISs who reported higher place dependence, stigma toward help-seeking, and fear of negative evaluation reported more fear about disclosing emotional parts of themselves to other group members in the presence of a group member from the same country of origin. The results showed that ISs' perceived difficulties in providing feedback to a group member in the presence of an IS from the same country of origin were predicted by low place identity, high place dependence, and more stigma. International students' willingness to disclose and provide feedback in a group counseling setting was compared in three different hypothetical situations based on other group members' demographics, and the results showed that ISs are more afraid of self-disclosure in the presence of an international student from the same country.

  8. Asian international students' barriers to joining group counseling.

    PubMed

    Lee, Ji-Yeon

    2014-10-01

    This cross-sectional study examined anticipated reactions to group participation among Asian international students (ISs). Structural equation modeling confirmed that Asian ISs' (n = 180) level of acculturation was associated with their attitude toward joining group counseling, which is partially mediated by their stigma toward help-seeking. The results of multiple regression analyses indicated that ISs who reported higher place dependence, stigma toward help-seeking, and fear of negative evaluation reported more fear about disclosing emotional parts of themselves to other group members in the presence of a group member from the same country of origin. The results showed that ISs' perceived difficulties in providing feedback to a group member in the presence of an IS from the same country of origin were predicted by low place identity, high place dependence, and more stigma. International students' willingness to disclose and provide feedback in a group counseling setting was compared in three different hypothetical situations based on other group members' demographics, and the results showed that ISs are more afraid of self-disclosure in the presence of an international student from the same country. PMID:25188562

  9. Second non-breast primary cancer following adjuvant therapy for early breast cancer: A report from the International Breast Cancer Study Group

    PubMed Central

    Gianni, Lorenzo; Gelber, Shari; Ravaioli, Alberto; Price, Karen N.; Panzini, Ilaria; Fantini, Manuela; Castiglione-Gertsch, Monica; Pagani, Olivia; Simoncini, Edda; Gelber, Richard D.; Coates, Alan S.; Goldhirsch, Aron

    2009-01-01

    The incidence of second non-breast primary cancer following adjuvant treatment was evaluated using data from patients enrolled from 1978 to 1999 in four International Breast Cancer Study Group (IBCSG) trials. The occurrence of these tumours as sites of first failure was assessed separately for two treatment comparisons: toremifene versus tamoxifen for five years in 1035 patients in IBCSG Trials 12-93 and 14-93 with a median follow-up of eight years and endocrine therapy (toremifene or tamoxifen) versus chemoendocrine therapy (CMF or AC plus toremifene or tamoxifen) in 1731 patients from IBCSG Trials III, VII and 12-93, with a combined median follow-up of 14 years. No significant differences in second non-breast primary tumours were observed in either comparison. In particular the incidences of second primary uterine tumours with toremifene and tamoxifen were similar and no significant increase of secondary leukaemias was observed with chemoendocrine therapy compared with endocrine therapy. PMID:19062268

  10. Simulation in International Studies

    ERIC Educational Resources Information Center

    Boyer, Mark A.

    2011-01-01

    Social scientists have long worked to replicate real-world phenomena in their research and teaching environments. Unlike our biophysical science colleagues, we are faced with an area of study that is not governed by the laws of physics and other more predictable relationships. As a result, social scientists, and international studies scholars more…

  11. Modern International Research Groups: Networks and Infrastructure

    NASA Astrophysics Data System (ADS)

    Katehi, Linda

    2009-05-01

    In a globalized economy, education and research are becoming increasing international in content and context. Academic and research institutions worldwide try to internationalize their programs by setting formal or informal collaborations. An education that is enhanced by international experiences leads to mobility of the science and technology workforce. Existing academic cultures and research structures are at odds with efforts to internationalize education. For the past 20-30 years, the US has recognized the need to improve the abroad experience of our scientists and technologists: however progress has been slow. Despite a number of both federally and privately supported programs, efforts to scale up the numbers of participants have not been satisfactory. The exchange is imbalanced as more foreign scientists and researchers move to the US than the other way around. There are a number of issues that contribute to this imbalance but we could consider the US academic career system, as defined by its policies and practices, as a barrier to internationalizing the early career faculty experience. Strict curricula, pre-tenure policies and financial commitments discourage students, post doctoral fellows and pre-tenure faculty from taking international leaves to participate in research abroad experiences. Specifically, achieving an international experience requires funding that is not provided by the universities. Furthermore, intellectual property requirements and constraints in pre-tenure probationary periods may discourage students and faculty from collaborations with peers across the Atlantic or Pacific or across the American continent. Environments that support early career networking are not available. This presentation will discuss the increasing need for international collaborations and will explore the need for additional programs, more integration, better conditions and improved infrastructures that can encourage and support mobility of scientists. In addition

  12. Retreating recurrent breast cancer with the same CMF-containing regimen used as adjuvant therapy. The International Breast Cancer Study Group.

    PubMed

    Castiglione-Gertsch, M; Tattersall, M; Hacking, A; Goldhirsch, A; Gudgeon, A; Gelber, R D; Lindtner, J; Coates, A; Collins, J; Isley, M; Senn, H J; Rudenstam, C M

    1997-12-01

    Breast cancer metastases appearing soon after adjuvant chemotherapy (within 12 months of its completion) are usually resistant to retreatment with the same cytotoxic agents, while relapses occurring later (beyond 12 months) regress when rechallenged with the same agents, showing similar response rates observed in non-pretreated patients with advanced disease. The International Breast Cancer Study Group (IBCSG) prospectively explored the efficacy of retreatment for patients upon relapse using the same therapy administered during the adjuvant programme. 87 patients previously treated with an adjuvant CMF (cyclophosphamide, methotrexate, 5-fluorouracil) combination chemotherapy (with or without the addition of low-dose prednisone and tamoxifen), who had measurable first breast cancer relapse, usually after at least 6 months of completion of the adjuvant treatment, were treated with CMF. Pretreatment consisted of 1-3 CMF courses in 27 patients and 4 or more courses in 60 patients. 17 patients were retreated with additional tamoxifen or had tamoxifen stopped at relapse. The data of these patients are shown separately. 47 of the 86 fully evaluable patients (55%) had an objective response, which was complete in 25 (29%). The dominant metastatic type and the number of involved sites were the most important factors influencing response to retreatment. Patients with soft tissue metastases had a high response rate (36/52, 69%) compared with those who had visceral involvement (9/24, 38%) or those with bony disease (2/10, 20%) (P = 0.002). In conclusion, response rates to retreatment with CMF were similar to those expected in a non-pretreated population. The patterns of relapse and the number of metastatic sites were the most important factors predicting response to retreatment, while treatment-free interval (usually longer than 6 months due to the study design) did not influence response rates. This study supports the hypothetic effectiveness of late reintroduction of adjuvant

  13. International Technical Working Group Round Robin Tests

    SciTech Connect

    Dudder, Gordon B.; Hanlen, Richard C.; Herbillion, Georges M.

    2003-02-01

    The goal of nuclear forensics is to develop a preferred approach to support illicit trafficking investigations. This approach must be widely understood and accepted as credible. The principal objectives of the Round Robin Tests are to prioritize forensic techniques and methods, evaluate attribution capabilities, and examine the utility of database. The HEU (Highly Enriched Uranium) Round Robin, and previous Plutonium Round Robin, have made tremendous contributions to fulfilling these goals through a collaborative learning experience that resulted from the outstanding efforts of the nine participating internal laboratories. A prioritized list of techniques and methods has been developed based on this exercise. Current work is focused on the extent to which the techniques and methods can be generalized. The HEU Round Robin demonstrated a rather high level of capability to determine the important characteristics of the materials and processes using analytical methods. When this capability is combined with the appropriate knowledge/database, it results in a significant capability to attribute the source of the materials to a specific process or facility. A number of shortfalls were also identified in the current capabilities including procedures for non-nuclear forensics and the lack of a comprehensive network of data/knowledge bases. The results of the Round Robin will be used to develop guidelines or a ''recommended protocol'' to be made available to the interested authorities and countries to use in real cases.

  14. Socialization and selection effects in the association between weight conscious peer groups and thin-ideal internalization: A co-twin control study.

    PubMed

    VanHuysse, Jessica L; Burt, S Alexandra; O'Connor, Shannon M; Thompson, J Kevin; Klump, Kelly L

    2016-06-01

    Affiliation with weight conscious peer groups is theorized to increase thin-ideal internalization through socialization processes. However, selection effects could contribute if genetic and/or environmental predispositions lead to affiliation with weight conscious peers. Co-twin control methodology was used to examine socialization and selection effects in 614 female twins (ages 8-15) from the Michigan State University Twin Registry (MSUTR). Thin-ideal internalization and peer group characteristics were assessed via self-report questionnaires. Results suggested the presence of both socialization and selection effects. In terms of socialization, twins who reported increased exposure to weight conscious peers relative to their co-twins had elevated thin-ideal internalization scores, regardless of zygosity. However, associations between weight conscious peers and thin-ideal internationalization within twin pairs were attenuated, suggesting that genetic and shared environmental selection effects also contribute. Findings significantly extend previous work by confirming the presence of socialization processes and highlighting selection processes to be examined in future longitudinal research. PMID:26859605

  15. Micronucleus frequencies in groups receiving external or internal radiation

    PubMed Central

    Özdal, Ayşegül; Erselcan, Taner; Özdemir, Öztürk; Silov, Güler; Erdoğan, Zeynep; Turhal, Özgül

    2016-01-01

    Objective: In the current study, we aimed to explore whether there is alteration between pre- and post-treatment micronucleus (MN) frequencies induced by internal and external ionizing radiation. Materials and Methods: The study enrolled a total of 67 patients including patients admitted to our hospital for treatment of hyperthyroidism (n = 17), scanning with low-dose I-131 (n = 15), and ablative therapy with high-dose I-131 (n = 15) at Department of Nuclear Medicine as well as patients with different diagnoses receiving external radiotherapy with various doses and durations at Department of Radiation Oncology (n = 20). Thirty-two patients who received radioactive iodine and returned for a follow-up visit at 1 month. Results: Considering both pre- and post-treatment MN frequencies of each group, lowest MN frequencies were detected for patients undergoing screening with low-dose I-131, and highest MN frequencies were found in radiotherapy patients. Comparison of pre- and post-treatment MN frequencies among hyperthyroidism, when pre- and post-treatment MN frequencies compared among hyperthyroidism, I-131 whole body scanning, ablation, and radiotherapy patient groups differences between MN frequencies were significant for each group (P < 0.05). Conclusion: Our study showed that MN analysis might be of value in determining chromosome damage that could potentially occur in patients exposed to internal and external radiation. PMID:27385886

  16. Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation--an International Primary Central Nervous System Lymphoma Study Group project.

    PubMed

    Bromberg, Jacoline E; Doorduijn, Jeanette K; Illerhaus, Gerald; Jahnke, Kristoph; Korfel, Agniezka; Fischer, Lars; Fritsch, Kristina; Kuittinen, Outti; Issa, Samar; van Montfort, Cees; van den Bent, Martin J

    2013-05-01

    Autologous stem cell transplantation has greatly improved the prognosis of systemic recurrent non-Hodgkin's lymphoma. However, no prospective data are available concerning the feasibility and efficacy of this strategy for systemic lymphoma relapsing in the central nervous system. We, therefore, we performed an international multicenter retrospective study of patients with a central nervous system recurrence of systemic lymphoma to assess the outcome of these patients in the era of stem cell transplantation. We collected clinical and treatment data on patients with a first central nervous system recurrence of systemic lymphoma treated between 2000 and 2010 in one of five centers in four countries. Patient- and treatment-related factors were analyzed and compared descriptively. Primary outcome measures were overall survival and percentage of patients transplanted. We identified 92 patients, with a median age of 59 years and a median Eastern Cooperative Oncology Group/World Health Organization performance status of 2, of whom 76% had diffuse large B-cell histology. The majority (79%) of these patients were treated with systemic chemotherapy with or without intravenous rituximab. Twenty-seven patients (29%) were transplanted; age and insufficient response to induction chemotherapy were the main reasons for not being transplanted in the remaining 65 patients. The median overall survival was 7 months (95% confidence interval 2.6-11.4), being 8 months (95% confidence interval 3.8-5.2) for patients ≤ 65 years old. The 1-year survival rate was 34.8%; of the 27 transplanted patients 62% survived more than 1 year. The Memorial Sloan Kettering Prognostic Index for primary central nervous system lymphoma was prognostic for both undergoing transplantation and survival. In conclusion, despite the availability of autologous stem cell transplantation for patients with central nervous system progression or relapse of systemic lymphoma, prognosis is still poor. Long-term survival

  17. Focus Group Study of Chinese International Students' Knowledge and Beliefs About HPV Vaccination, Before and After Reading an Informational Pamphlet About Gardasil(®).

    PubMed

    Gao, Haijuan; Okoror, Titilayo A; Hyner, Gerald C

    2016-10-01

    An increasing need for Human Papillomavirus (HPV) vaccines in China remains unmet in the mainland and the knowledge and intentions of Chinese youth regarding vaccination is unknown. In the fall of 2013, 44 Chinese international students (CIS) attending a university in the United States Midwest participated in 10 focus group discussions (five female and five male). Result showed that participants have limited awareness and knowledge about HPV infection and vaccination, participants erroneously believed that the causes of cervical cancer are abortion and miscarriage. Participants rely heavily on informal sources such as Chinese-based social media platforms and personal social networks for information on sexually transmitted infections. Sexual cultures and behaviors are perceived differently between CIS born in the 1990s and 1980s. Interestingly, participants' perceived stigma about HPV infection decreased with improving knowledge level during group discussions. In conclusion, HPV vaccine should be further promoted alongside sex education among CIS. PMID:26831655

  18. Focus Group Study of Chinese International Students' Knowledge and Beliefs About HPV Vaccination, Before and After Reading an Informational Pamphlet About Gardasil(®).

    PubMed

    Gao, Haijuan; Okoror, Titilayo A; Hyner, Gerald C

    2016-10-01

    An increasing need for Human Papillomavirus (HPV) vaccines in China remains unmet in the mainland and the knowledge and intentions of Chinese youth regarding vaccination is unknown. In the fall of 2013, 44 Chinese international students (CIS) attending a university in the United States Midwest participated in 10 focus group discussions (five female and five male). Result showed that participants have limited awareness and knowledge about HPV infection and vaccination, participants erroneously believed that the causes of cervical cancer are abortion and miscarriage. Participants rely heavily on informal sources such as Chinese-based social media platforms and personal social networks for information on sexually transmitted infections. Sexual cultures and behaviors are perceived differently between CIS born in the 1990s and 1980s. Interestingly, participants' perceived stigma about HPV infection decreased with improving knowledge level during group discussions. In conclusion, HPV vaccine should be further promoted alongside sex education among CIS.

  19. Comparison of the COPD Population Screener and International Primary Care Airway Group questionnaires in a general Japanese population: the Hisayama study

    PubMed Central

    Tsukuya, Go; Samukawa, Takuya; Matsumoto, Koichiro; Fukuyama, Satoru; Kumamoto, Tomohiro; Uchida, Akifumi; Koriyama, Chihaya; Ninomiya, Toshiharu; Inoue, Hiromasa

    2016-01-01

    Background The incidence of chronic obstructive pulmonary disease (COPD) is increasing worldwide. In Japan and other countries, epidemiological studies have found that many patients with COPD are underdiagnosed and untreated, and thus, early detection and treatment of COPD has been emphasized. Screening questionnaires may have utility in the initial detection of COPD. Objective This study aimed to validate and compare the COPD Population Screener (COPD-PS) and the International Primary Care Airway Group (IPAG) questionnaires in a general Japanese population. Patients and methods Eligible subjects 40 years of age and older living in the town of Hisayama were solicited to participate in a health checkup in 2012. All subjects 40–79 years of age without physician-diagnosed asthma or lung resection were recruited, and 2,336 subjects who fully completed both questionnaires and who had valid spirometry measurements were analyzed. Persistent airflow obstruction (AO) was defined by a postbronchodilator forced expiratory volume in 1 second/forced vital capacity <0.70. Receiver operating characteristic curves, net reclassification improvement, and integrated discrimination improvement were used to examine the ability of the COPD-PS and IPAG questionnaires to discriminate between subjects with and without AO. Results The overall area under the receiver operating characteristic curve for the COPD-PS questionnaire was 0.747 (95% confidence interval [CI], 0.707–0.788) and for the IPAG was 0.775 (95% CI, 0.735–0.816), with no significant difference (P=0.09). The net reclassification improvement and integrated discrimination improvement were −0.107 (95% CI, −0.273–0.058; P=0.203) and −0.014 (95% CI, −0.033–0.006; P=0.182), respectively. Conclusion The five-item COPD-PS questionnaire was comparable to the eight-item IPAG for discriminating between subjects with and without AO. The COPD-PS is a simple and useful screening questionnaire for persistent AO. PMID

  20. Study Groups: Conduit for Reform.

    ERIC Educational Resources Information Center

    Makibbin, Shirley S.; Sprague, Marsha M.

    This conference presentation describes study groups as a mechanism for changing teacher behavior. The history of study groups is discussed, beginning with the first American study groups organized by Benjamin Franklin; the Chautauqua Literary and Scientific Circle; the waning of study groups in the early 20th century as college enrollment…

  1. Focus Groups: An Important Research Technique for Internal Evaluation Units.

    ERIC Educational Resources Information Center

    Duffy, Barbara Poitras

    1993-01-01

    The use of focus groups by the Federal Bureau of Investigation as a tool of internal evaluation is described. Focus groups are used in an environment where credibility is key to achieving meaningful cooperation. Issues for consideration by other evaluators interested in the approach are summarized. (SLD)

  2. Selected Theoretical Studies Group contributions to the 14th International Cosmic Ray conference. [including studies on galactic molecular hydrogen, interstellar reddening, and on the origin of cosmic rays

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The galactic distribution of H2 was studied through gamma radiation and through X-ray, optical, and infrared absorption measurements from SAS-2 and other sources. A comparison of the latitude distribution of gamma-ray intensity with reddening data shows reddening data to give the best estimate of interstellar gas in the solar vicinity. The distribution of galactic cosmic ray nucleons was determined and appears to be identical to the supernova remnant distribution. Interactions between ultrahigh energy cosmic-ray nuclei and intergalactic photon radiation fields were calculated, using the Monte Carlo method.

  3. Metastatic Neuroblastoma Confined to Distant Lymph Nodes (stage 4N) Predicts Outcome in Patients With Stage 4 Disease: A Study From the International Neuroblastoma Risk Group Database

    PubMed Central

    Morgenstern, Daniel A.; London, Wendy B.; Stephens, Derek; Volchenboum, Samuel L.; Hero, Barbara; Di Cataldo, Andrea; Nakagawara, Akira; Shimada, Hiroyuki; Ambros, Peter F.; Matthay, Katherine K.; Cohn, Susan L.; Pearson, Andrew D.J.; Irwin, Meredith S.

    2014-01-01

    Purpose The presence of distant metastases is one of the most powerful predictors of outcome in patients with neuroblastoma. However, the pattern of metastatic spread is not incorporated into current risk stratification systems. Small case series have suggested that patients with neuroblastoma who have metastatic disease limited to distant lymph nodes (4N disease) may have improved outcomes. Patients and Methods We analyzed retrospective data from the International Neuroblastoma Risk Group database for patients diagnosed from 1990 to 2002. 4N patients were compared with the remaining stage 4 patients (non-4N), excluding those with missing metastatic site data. Results In all, 2,250 International Neuroblastoma Staging System stage 4 patients with complete data were identified, of whom 146 (6.5%) had 4N disease. For 4N patients, event-free survival (EFS; 5-year, 77% ± 4%) and overall survival (OS; 5-year, 85% ± 3%) were significantly better than EFS (5-year, 35% ± 1%) and OS (5-year, 42% ± 1%) for non-4N stage 4 patients (P < .001). 4N patients were more likely to be younger (P < .001) and have tumors with favorable characteristics, including absence of MYCN amplification (89% v 69%; P < .001). In a multivariable analysis, 4N disease remained a significant predictor of outcome (hazard ratio for non-4N v 4N: 3.40 for EFS and 3.69 for OS). Within subgroups defined by age at diagnosis and tumor MYCN status, 4N disease was significantly associated with improved outcomes. Conclusion 4N represents a subgroup with better outcome than that of other patients with metastatic disease. These findings suggest that the biology and treatment response of 4N tumors differ from other stage 4 tumors, and less intensive therapy should be considered for this cohort. Future exploration of biologic factors determining the pattern of metastatic spread is warranted. PMID:24663047

  4. Emergency room referral to internal medicine wards or to coronary care units of patients with first acute myocardial infarction. Israel Study Group on First Acute Myocardial Infarction.

    PubMed

    Drory, Y; Shapira, I; Goldbourt, U; Fisman, E Z; Villa, Y; Tenenbaum, A; Pines, A

    2000-01-01

    The objective of the study was to assess factors associated with ward assignment in the emergency room for patients < or = 65 years old with first acute myocardial infarction. We analysed uni- and multivariate predictors for ward assignment (coronary care unit versus internal ward). Eight major centrally located Israeli hospitals provided data during one year. The study population included 1252 patients, of whom 83% were men, 37% were hypertensives, 22% were diabetics, and 14% had previous anginal syndrome. Most patients (83%) were admitted to the coronary care unit. Internal medicine ward assignment was significantly associated with advanced age, history of hypertension or diabetes, a longer time from appearance of symptoms to arrival at the hospital, and myocardial infarction type (non-Q-wave or non-anterior). The likelihood of medical ward referral increased stepwise with the increasing number of a patient's predictive factors: those with > or = 4 factors had a > 30% chance of being assigned to a medical ward compared to a < 10% chance when there were 0-3 risk factors. Exclusion of patients with thrombolysis had no effect on the results. The shortage of cardiac care unit beds apparently leads to emergency room selection acting in detriment of patients with poorest prognoses. Clear guidelines for decision making in the emergency room are needed to resolve this paradoxical situation. PMID:10998758

  5. COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups

    PubMed Central

    2013-01-01

    Background A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders. Methods/Design Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress. Discussion The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing. PMID:24195705

  6. A comparison of interferon alfa-2a and podophyllin in the treatment of primary condylomata acuminata. The Condylomata International Collaborative Study Group.

    PubMed Central

    1991-01-01

    OBJECTIVES--to compare the response to treatment and recurrence rate of condylomata accuminata using subcutaneous injection of interferon alfa 2a 1.5 million units three times weekly for four weeks, or podophyllin resin 25% applied to lesions twice weekly for up to six weeks. DESIGN--Randomised open study. SETTING--Multicentre European study in genitourinary medicine, dermatovenereology, and gynaecology departments. PATIENTS--87 males and 67 females with condylomata acuminata for less than six months and no history of previous treatment. MAIN OUTCOME MEASURES--Complete clearance of lesions and evidence of recurrence at three months and nine months after treatment commenced. RESULTS--A complete response was achieved at three months in 15 of 64 (23%) in the interferon treated group, and 31 of 69 (45%) in the podophyllin treated group (p = 0.003). At nine months 10 of 13 patients in the interferon group and 22 of 30 patients in the podophyllin group remained completely clear of lesions. PMID:1743712

  7. Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database.

    PubMed

    Morgenstern, Daniel A; London, Wendy B; Stephens, Derek; Volchenboum, Samuel L; Simon, Thorsten; Nakagawara, Akira; Shimada, Hiroyuki; Schleiermacher, Gudrun; Matthay, Katherine K; Cohn, Susan L; Pearson, Andrew D J; Irwin, Meredith S

    2016-09-01

    Neuroblastoma is a childhood cancer with remarkably divergent tumour behaviour and the presence of metastatic disease is a powerful predictor of adverse outcome. However, the importance of the involvement of specific metastatic sites or overall metastatic burden in determining outcome has not been fully explored. We analysed data from the International Neuroblastoma Risk Group database for 2250 patients with stage 4 disease treated from 1990 to 2002. Metastatic burden was assessed using a 'metastatic site index' (MSI), a score based on the number of metastatic systems involved. Overall, involvement of bone marrow, bone, lung, central nervous system, or other sites was associated with worse outcome. For patients aged ≥18 months, involvement of liver had the greatest impact on outcome and was associated with tumour MYCN amplification and adrenal primary and lung metastases. Increased MSI was associated with worse outcome and higher baseline ferritin/lactate dehydrogenase. We explored the impact of initial treatment approach on these associations. Limiting the analysis to patients allocated to protocols including stem cell transplant (SCT), there was no longer an association of outcome with metastatic involvement of any individual system or increasing MSI. Thus, treatment escalation with SCT (and the addition of differentiating agents to maintenance therapy) appears to have provided maximal benefit to patients with greatest metastatic disease burden. These findings underscore the importance of examining prognostic factors in the context of specific treatments since the addition of new therapies may change or even negate the predictive impact of a particular variable. PMID:27434878

  8. Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database.

    PubMed

    Morgenstern, Daniel A; London, Wendy B; Stephens, Derek; Volchenboum, Samuel L; Simon, Thorsten; Nakagawara, Akira; Shimada, Hiroyuki; Schleiermacher, Gudrun; Matthay, Katherine K; Cohn, Susan L; Pearson, Andrew D J; Irwin, Meredith S

    2016-09-01

    Neuroblastoma is a childhood cancer with remarkably divergent tumour behaviour and the presence of metastatic disease is a powerful predictor of adverse outcome. However, the importance of the involvement of specific metastatic sites or overall metastatic burden in determining outcome has not been fully explored. We analysed data from the International Neuroblastoma Risk Group database for 2250 patients with stage 4 disease treated from 1990 to 2002. Metastatic burden was assessed using a 'metastatic site index' (MSI), a score based on the number of metastatic systems involved. Overall, involvement of bone marrow, bone, lung, central nervous system, or other sites was associated with worse outcome. For patients aged ≥18 months, involvement of liver had the greatest impact on outcome and was associated with tumour MYCN amplification and adrenal primary and lung metastases. Increased MSI was associated with worse outcome and higher baseline ferritin/lactate dehydrogenase. We explored the impact of initial treatment approach on these associations. Limiting the analysis to patients allocated to protocols including stem cell transplant (SCT), there was no longer an association of outcome with metastatic involvement of any individual system or increasing MSI. Thus, treatment escalation with SCT (and the addition of differentiating agents to maintenance therapy) appears to have provided maximal benefit to patients with greatest metastatic disease burden. These findings underscore the importance of examining prognostic factors in the context of specific treatments since the addition of new therapies may change or even negate the predictive impact of a particular variable.

  9. The International Space Life Sciences Strategic Planning Working Group

    NASA Technical Reports Server (NTRS)

    White, Ronald J.; Rabin, Robert; Lujan, Barbara F.

    1993-01-01

    Throughout the 1980s, ESA and the space agencies of Canada, Germany, France, Japan, and the U.S. have pursued cooperative projects bilaterally and multilaterally to prepare for, and to respond to, opportunities in space life sciences research previously unapproachable in scale and sophistication. To cope effectively with likely future space research opportunities, broad, multilateral, coordinated strategic planning is required. Thus, life scientists from these agencies have allied to form the International Space Life Sciences Strategic Planning Working Group. This Group is formally organized under a charter that specifies the purpose of the Working Group as the development of an international strategic plan for the space life sciences, with periodic revisions as needed to keep the plan current. The plan will be policy-, not operations-oriented. The Working Group also may establish specific implementation teams to coordinate multilateral science policy in specific areas; such teams have been established for space station utilization, and for sharing of flight equipment.

  10. Internal medicine residency redesign: proposal of the Internal Medicine Working Group.

    PubMed

    Horwitz, Ralph I; Kassirer, Jerome P; Holmboe, Eric S; Humphrey, Holly J; Verghese, Abraham; Croft, Carol; Kwok, Minjung; Loscalzo, Joseph

    2011-09-01

    Concerned with the quality of internal medicine training, many leaders in the field assembled to assess the state of the residency, evaluate the decline in interest in the specialty, and create a framework for invigorating the discipline. Although many external factors are responsible, we also found ourselves culpable: allowing senior role models to opt out of important training activities, ignoring a progressive atrophy of bedside skills, and focusing on lock-step curricula, lectures, and compiled diagnostic and therapeutic strategies. The group affirmed its commitment to a vision of internal medicine rooted in science and learned with mentors at the bedside. Key factors for new emphasis include patient-centered small group teaching, greater incorporation of clinical epidemiology and health services research, and better schedule control for trainees. Because previous proposals were weakened by lack of evidence, we propose to organize the Cooperative Educational Studies Group, a pool of training programs that will collect a common data set describing their programs, design interventions to be tested rigorously in multi-methodological approaches, and at the same time produce knowledge about high-quality practice. PMID:21854887

  11. Introduction of the UNIX International Performance Management Work Group

    NASA Technical Reports Server (NTRS)

    Newman, Henry

    1993-01-01

    In this paper we presented the planned direction of the UNIX International Performance Management Work Group. This group consists of concerned system developers and users who have organized to synthesize recommendations for standard UNIX performance management subsystem interfaces and architectures. The purpose of these recommendations is to provide a core set of performance management functions and these functions can be used to build tools by hardware system developers, vertical application software developers, and performance application software developers.

  12. Promoting Professional Student Learning through Study Groups: A Case Study

    ERIC Educational Resources Information Center

    Shaw, Donita Massengill

    2011-01-01

    The purpose of this research was to analyze how 24 graduate students perceived the study group experience and how study groups fostered a change in their knowledge and teaching of comprehension. Data sources included pre-post questionnaires, text concepts, International Reading Association process form, facilitator logs, and post-survey. Data were…

  13. Hanford Waste Tank Grouping Study

    SciTech Connect

    Remund, K.M.; Simpson, B.C.

    1996-09-30

    This letter report discusses the progress and accomplishments of the Tank Grouping Study in FY96. Forty-one single-shell tanks (SSTs) were included in the FY95. In FY96, technical enhancements were also made to data transformations and tank grouping methods. The first focus of the FY96 effort was a general tank grouping study in which the 41 SSTs were grouped into classes with similar waste properties. The second FY96 focus was a demonstration of how multivariate statistical methods can be used to help resolve tank safety issues.

  14. 75 FR 26794 - Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena Park, CA; Alticor, Inc., Including Access Business Group International LLC, and... 12, 2010, applicable to workers of Alticor, Inc., including Access Business Group International...

  15. 76 FR 45878 - Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena Park, CA; Alticor, Inc., Including Access Business Group International LLC and..., Ada, MI; Alticor, Inc., Including Access Business Group International LLC and Amway...

  16. 75 FR 32221 - Alticor, Inc., Including Access Business Group International, LLC, and Amway Corporation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International, LLC, and..., applicable to workers of Alticor, Inc., including Access Business Group International, LLC and Amway... location of Alticor, Inc., including Access Business Group International, LLC and Amway Corporation....

  17. International Technical Working Group Cooperation to Counter Illicit Nuclear Trafficking

    SciTech Connect

    Smith, D K; Niemeyer, S

    2004-09-18

    The Nuclear Smuggling International Technical Working Group (ITWG) is an international body of nuclear forensic experts that cooperate to deter the illicit trafficking of nuclear materials. The objective of the ITWG is to provide a common approach and effective technical solutions to governments who request assistance in nuclear forensics. The ITWG was chartered in 1996 and since that time more than 28 nations and organizations have participated in 9 international meetings and 2 analytical round-robin trials. Soon after its founding the ITWG adopted a general framework to guide nuclear forensics investigations that includes recommendations for nuclear crime scene security and analysis, the best application of radioanalytical methods, the conduct of traditional forensic analysis of contaminated materials, and effective data analysis to interpret the history of seized nuclear materials. This approach has been adopted by many nations as they respond to incidents of illicit nuclear trafficking.

  18. Internal character dictates transition dynamics between isolation and cohesive grouping

    NASA Astrophysics Data System (ADS)

    Manrique, Pedro D.; Hui, Pak Ming; Johnson, Neil F.

    2015-12-01

    We show that accounting for internal character among interacting heterogeneous entities generates rich transition behavior between isolation and cohesive dynamical grouping. Our analytical and numerical calculations reveal different critical points arising for different character-dependent grouping mechanisms. These critical points move in opposite directions as the population's diversity decreases. Our analytical theory may help explain why a particular class of universality is so common in the real world, despite the fundamental differences in the underlying entities. It also correctly predicts the nonmonotonic temporal variation in connectivity observed recently in one such system.

  19. Proceedings of the Twentieth International Microgravity Measurements Group Meeting

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard (Compiler)

    2001-01-01

    The International Microgravity Measurements Group annual meetings provide a forum for an exchange of information and ideas about various aspects of microgravity acceleration research in international microgravity research programs. These meetings are sponsored by the PI Microgravity Services (PIMS) project at the NASA Glenn Research Center. The twentieth MGMG meeting was held 7-9 August 2001 at the Hilton Garden Inn Hotel in Cleveland, Ohio. The 35 attendees represented NASA, other space agencies, universities, and commercial companies; eight of the attendees were international representatives from Canada, Germany, Italy, Japan, and Russia. Seventeen presentations were made on a variety of microgravity environment topics including the International Space Station (ISS), acceleration measurement and analysis results, science effects from microgravity accelerations, vibration isolation, free flyer satellites, ground testing, and microgravity outreach. Two working sessions were included in which a demonstration of ISS acceleration data processing and analyses were performed with audience participation. Contained within the minutes is the conference agenda which indicates each speaker, the title of their presentation, and the actual time of their presentation. The minutes also include the charts for each presentation which indicate the author's name(s) and affiliation. In some cases, a separate written report was submitted and has been included here.

  20. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group

    PubMed Central

    Palumbo, Antonio; Avet-Loiseau, Hervé; Oliva, Stefania; Lokhorst, Henk M.; Goldschmidt, Hartmut; Rosinol, Laura; Richardson, Paul; Caltagirone, Simona; Lahuerta, Juan José; Facon, Thierry; Bringhen, Sara; Gay, Francesca; Attal, Michel; Passera, Roberto; Spencer, Andrew; Offidani, Massimo; Kumar, Shaji; Musto, Pellegrino; Lonial, Sagar; Petrucci, Maria T.; Orlowski, Robert Z.; Zamagni, Elena; Morgan, Gareth; Dimopoulos, Meletios A.; Durie, Brian G.M.; Anderson, Kenneth C.; Sonneveld, Pieter; San Miguel, Jésus; Cavo, Michele; Rajkumar, S. Vincent; Moreau, Philippe

    2015-01-01

    Purpose The clinical outcome of multiple myeloma (MM) is heterogeneous. A simple and reliable tool is needed to stratify patients with MM. We combined the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate their prognostic value in newly diagnosed MM (NDMM). Patients and Methods Clinical and laboratory data from 4,445 patients with NDMM enrolled onto 11 international trials were pooled together. The K-adaptive partitioning algorithm was used to define the most appropriate subgroups with homogeneous survival. Results ISS, CA, and LDH data were simultaneously available in 3,060 of 4,445 patients. We defined the following three groups: revised ISS (R-ISS) I (n = 871), including ISS stage I (serum β2-microglobulin level < 3.5 mg/L and serum albumin level ≥ 3.5 g/dL), no high-risk CA [del(17p) and/or t(4;14) and/or t(14;16)], and normal LDH level (less than the upper limit of normal range); R-ISS III (n = 295), including ISS stage III (serum β2-microglobulin level > 5.5 mg/L) and high-risk CA or high LDH level; and R-ISS II (n = 1,894), including all the other possible combinations. At a median follow-up of 46 months, the 5-year OS rate was 82% in the R-ISS I, 62% in the R-ISS II, and 40% in the R-ISS III groups; the 5-year PFS rates were 55%, 36%, and 24%, respectively. Conclusion The R-ISS is a simple and powerful prognostic staging system, and we recommend its use in future clinical studies to stratify patients with NDMM effectively with respect to the relative risk to their survival. PMID:26240224

  1. One center in Brussels has consistently had the lowest HbA1c values in the 4 studies (1994-2009) by the Hvidoere International Study Group on Childhood Diabetes: What are the "recipes"?

    PubMed Central

    Dorchy, Harry

    2015-01-01

    The principal aims of therapeutic management of the child, adolescent and adult with type 1 diabetes are to allow good quality of life and to avoid long-term complications (retinopathy, neuropathy, nephropathy, cardiovascular disease, etc.) by maintaining blood glucose concentrations close to normal level. Glycated hemoglobin levels (HbA1c) provide a good criterion of overall glycemic control. The Hvidoere Study Group (HSG) on Childhood Diabetes, founded in 1994, is an international group representing about twenty highly experienced pediatric centers from Europe, North America, Japan and Australia. Four international comparisons of metabolic control (1995, 1998, 2005, 2009) have been performed. The one center that has consistently had the lowest HbA1c values (approximate 7.3% or 56.3 mmol/mol) is my center in Brussels. This is more often obtained with a twice-daily free-mixed regimen with additional supplemental fast insulins ad hoc. The so-called “Dorchy’s recipes” are summarized. The conclusion is that the number of daily insulin injections, 2 or ≥ 4, or the use of pumps, by itself does not necessarily give better results. Intensified therapy should not depend upon the number of insulin doses per day, by syringe, pen or pump but rather should be redefined as to intent-to-treat ascertainment (i.e., goals). When there are no mutually agreed upon goals for BG and/or HbA1c, when there is insufficient education and psychosocial support by the medical team or at home, there is likely to be poor outcomes, as shown by the HSG. One of our recipes is not to systematically replace rapid-acting human insulins by fast-acting analogues. Because the multicenter studies of the HSG, performed in developed countries without financial restriction, show that treatment of childhood diabetes is inadequate in general and that levels of HbA1c are very different, diabetes treatment teams should individually explore the reasons for failure, without any prejudice or bias. Any

  2. Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM).

    PubMed

    Della Porta, M G; Tuechler, H; Malcovati, L; Schanz, J; Sanz, G; Garcia-Manero, G; Solé, F; Bennett, J M; Bowen, D; Fenaux, P; Dreyfus, F; Kantarjian, H; Kuendgen, A; Levis, A; Cermak, J; Fonatsch, C; Le Beau, M M; Slovak, M L; Krieger, O; Luebbert, M; Maciejewski, J; Magalhaes, S M M; Miyazaki, Y; Pfeilstöcker, M; Sekeres, M A; Sperr, W R; Stauder, R; Tauro, S; Valent, P; Vallespi, T; van de Loosdrecht, A A; Germing, U; Haase, D; Greenberg, P L; Cazzola, M

    2015-07-01

    A risk-adapted treatment strategy is mandatory for myelodysplastic syndromes (MDS). We refined the World Health Organization (WHO)-classification-based Prognostic Scoring System (WPSS) by determining the impact of the newer clinical and cytogenetic features, and we compared its prognostic power to that of the revised International Prognostic Scoring System (IPSS-R). A population of 5326 untreated MDS was considered. We analyzed single WPSS parameters and confirmed that the WHO classification and severe anemia provide important prognostic information in MDS. A strong correlation was found between the WPSS including the new cytogenetic risk stratification and WPSS adopting original criteria. We then compared WPSS with the IPSS-R prognostic system. A highly significant correlation was found between the WPSS and IPSS-R risk classifications. Discrepancies did occur among lower-risk patients in whom the number of dysplastic hematopoietic lineages as assessed by morphology did not reflect the severity of peripheral blood cytopenias and/or increased marrow blast count. Moreover, severe anemia has higher prognostic weight in the WPSS versus IPSS-R model. Overall, both systems well represent the prognostic risk of MDS patients defined by WHO morphologic criteria. This study provides relevant in formation for the implementation of risk-adapted strategies in MDS. PMID:25721895

  3. International strategic minerals inventory summary report: platinum-group metals

    USGS Publications Warehouse

    Sutphin, David M.; Page, Norman J

    1986-01-01

    Major world resources of platinum-group metals are described in this summary report of information in the International Strategic Minerals Inventory {ISMI}. ISMI is a cooperative data-collection effort of earth-science and mineral-resource agencies in Australia, Canada, the Federal Republic of Germany, the Republic of South Africa, and the United States of America. This report, designed to be of benefit to policy analysts, contains two parts. Part I presents an overview of the resources and potential supply of platinum-group metals on the basis of inventory information. Part II contains tables of some of the geologic information and mineral-resource and production data that were collected by ISMI participants.

  4. Leaping into the Unknown: Experience of Counseling Students Participating in Group Work with International Students

    ERIC Educational Resources Information Center

    Choi, Kyoung Mi; Protivnak, Jake J.

    2016-01-01

    This research study used qualitative phenomenological methodology to explore counseling graduate students' experiences leading support groups for international students. Participants included 6 master's-level counseling students. The following 4 themes emerged to describe the counseling students' experience as group leaders: (a) individualistic…

  5. Loneliness and International Students: An Australian Study

    ERIC Educational Resources Information Center

    Sawir, Erlenawati; Marginson, Simon; Deumert, Ana; Nyland, Chris; Ramia, Gaby

    2008-01-01

    In a study of international student security, consisting of 200 intensive interviews with students, resident onshore in Australia, it was found that two thirds of the group had experienced problems of loneliness and/or isolation, especially in the early months. According to Weiss, students experience both "personal loneliness" because of the loss…

  6. International Piping Integrity Research Group (IPIRG) Program. Final report

    SciTech Connect

    Wilkowski, G.; Schmidt, R.; Scott, P.

    1997-06-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Program. The IPIRG Program was an international group program managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United States. The program objective was to develop data needed to verify engineering methods for assessing the integrity of circumferentially-cracked nuclear power plant piping. The primary focus was an experimental task that investigated the behavior of circumferentially flawed piping systems subjected to high-rate loadings typical of seismic events. To accomplish these objectives a pipe system fabricated as an expansion loop with over 30 meters of 16-inch diameter pipe and five long radius elbows was constructed. Five dynamic, cyclic, flawed piping experiments were conducted using this facility. This report: (1) provides background information on leak-before-break and flaw evaluation procedures for piping, (2) summarizes technical results of the program, (3) gives a relatively detailed assessment of the results from the pipe fracture experiments and complementary analyses, and (4) summarizes advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG program.

  7. International Instructional Systems: Social Studies

    ERIC Educational Resources Information Center

    Brant, Jacek; Chapman, Arthur; Isaacs, Tina

    2016-01-01

    This paper reports on research conducted as part of the International Instructional System Study that explored five subject areas across nine jurisdictions in six high-performing countries. The Study's overall aim was to understand what, if anything, there is in common in the curricula and assessment arrangements among the high-performing…

  8. Dummy Run of Quality Assurance Program in a Phase 3 Randomized Trial Investigating the Role of Internal Mammary Lymph Node Irradiation in Breast Cancer Patients: Korean Radiation Oncology Group 08-06 Study

    SciTech Connect

    Chung, Yoonsun; Kim, Jun Won; Shin, Kyung Hwan; Kim, Su Ssan; Ahn, Sung-Ja; Park, Won; Lee, Hyung-Sik; Kim, Dong Won; Lee, Kyu Chan; Suh, Hyun Suk; Kim, Jin Hee; Shin, Hyun Soo; Kim, Yong Bae; Suh, Chang-Ok

    2015-02-01

    Purpose: The Korean Radiation Oncology Group (KROG) 08-06 study protocol allowed radiation therapy (RT) technique to include or exclude breast cancer patients from receiving radiation therapy to the internal mammary lymph node (IMN). The purpose of this study was to assess dosimetric differences between the 2 groups and potential influence on clinical outcome by a dummy run procedure. Methods and Materials: All participating institutions were asked to produce RT plans without irradiation (Arm 1) and with irradiation to the IMN (Arm 2) for 1 breast-conservation treatment case (breast-conserving surgery [BCS]) and 1 mastectomy case (modified radical mastectomy [MRM]) whose computed tomography images were provided. We assessed interinstitutional variations in IMN delineation and evaluated the dose-volume histograms of the IMN and normal organs. A reference IMN was delineated by an expert panel group based on the study guidelines. Also, we analyzed the potential influence of actual dose variation observed in this study on patient survival. Results: Although physicians intended to exclude the IMN within the RT field, the data showed almost 59.0% of the prescribed dose was delivered to the IMN in Arm 1. However, the mean doses covering the IMN in Arm 1 and Arm 2 were significantly different for both cases (P<.001). Due to the probability of overdose in Arm 1, the estimated gain in 7-year disease-free survival rate would be reduced from 10% to 7.9% for BCS cases and 7.1% for MRM cases. The radiation doses to the ipsilateral lung, heart, and coronary artery were lower in Arm 1 than in Arm 2. Conclusions: Although this dummy run study indicated that a substantial dose was delivered to the IMN, even in the nonirradiation group, the dose differences between the 2 groups were statistically significant. However, this dosimetric profile should be studied further with actual patient samples and be taken into consideration when analyzing clinical outcomes according to IMN

  9. Risk of Progression and Survival in Multiple Myeloma Relapsing After Therapy with IMiDs and Bortezomib: A Multicenter International Myeloma Working Group Study

    PubMed Central

    Kumar, Shaji; Lee, Jae Hoon; Lahuerta, Juan J.; Morgan, Gareth; Richardson, Paul G.; Crowley, John; Haessler, Jeff; Feather, John; Hoering, Antje; Moreau, Philippe; LeLeu, Xavier; Hullin, Cyrille; Klein, Saskia K.; Sonneveld, Pieter; Siegel, David; Bladé, Joan; Goldschmidt, Hartmut; Jagannath, Sundar; San Miguel, Jesus; Orlowski, Robert; Palumbo, Antonio; Sezer, Orhan; Durie, Brian G.M.

    2014-01-01

    Promising new drugs are being evaluated for treatment of multiple myeloma (MM), but their impact should be measured against the expected outcome in patients failing current therapies. However, the natural history of relapsed disease in the current era remains unclear. We studied 286 patients with relapsed MM, who were refractory to bortezomib and were relapsed, refractory, or ineligible, to an IMiD (Immunomodulatory Drug), with measurable disease and ECOG PS of 0, 1 or 2. The date patients satisfied the entry criteria was defined as time zero (T0). The median age at diagnosis was 58 years and time from diagnosis to T0 was 3.3 years. Following T0, 213 (74%) patients had a treatment recorded with one or more regimens (median=1; range 0-8). The first regimen contained bortezomib in 55 (26%) patients and an IMiD in 70 (33%). A minor response or better was seen to at least one therapy after T0 in 94 patients (51%) including >=partial response in 69 (38%). The median overall survival and event free survival from T0 were 9 and 5 months respectively. This study confirms the poor outcome once patients become refractory to current treatments. The results provide context for interpreting ongoing trials of new drugs. PMID:21799510

  10. Frequency of del(12p) is commonly underestimated in myelodysplastic syndromes: Results from a German diagnostic study in comparison with an international control group.

    PubMed

    Braulke, Friederike; Müller-Thomas, Catharina; Götze, Katharina; Platzbecker, Uwe; Germing, Ulrich; Hofmann, Wolf-Karsten; Giagounidis, Aristoteles A N; Lübbert, Michael; Greenberg, Peter L; Bennett, John M; Solé, Francesc; Slovak, Marilyn L; Ohyashiki, Kazuma; Le Beau, Michelle M; Tüchler, Heinz; Pfeilstöcker, Michael; Hildebrandt, Barbara; Aul, Carlo; Stauder, Reinhard; Valent, Peter; Fonatsch, Christa; Bacher, Ulrike; Trümper, Lorenz; Haase, Detlef; Schanz, Julie

    2015-12-01

    In myelodysplastic syndromes (MDS), deletion of the short arm of chromosome 12 (del(12p)) is usually a small abnormality, rarely detected as a single aberration by chromosome banding analysis (CBA) of bone marrow metaphases. Del(12p) has been described in 0.6 to 5% of MDS patients at initial diagnosis and is associated with a good to intermediate prognosis as a sole anomaly according to current scoring systems. Here, we present the results of a systematic del(12p) testing in a German prospective diagnostic study (clinicaltrials.gov: NCT01355913) on 367 MDS patients in whom CD34+ peripheral blood cells were analysed for the presence of del(12p) by sequential fluorescence in situ hybridization (FISH) analyses. A cohort of 2,902 previously published MDS patients diagnosed by CBA served as control. We demonstrate that, using a sensitive FISH technique, 12p deletion occurs significantly more frequently in MDS than previously described (7.6% by CD34+ PB-FISH vs. 1.6% by CBA, P < 0.001) and is often associated with other aberrations (93% by CD34+ PB-FISH vs. 60% by CBA). Additionally, the detection rate can be increased by repeated analyses in a patient over time which is important for the patient´s prognosis to distinguish a sole anomaly from double or complex aberrations. To our knowledge, this is the first study to screen for 12p deletions with a suitable probe for ETV6/TEL in 12p13. Our data suggest that the supplement of a probe for the detection of a 12p deletion to common FISH probe panels helps to avoid missing a del(12p), especially as part of more complex aberrations.

  11. Geographic Considerations in International Studies.

    ERIC Educational Resources Information Center

    Kott, Richard F.

    Based on students' generally shallow knowledge of geographic concepts on the one hand and a new and almost universal awareness of man in his milieu on the other, the author seeks to draw attention to the discipline of geography, and more specifically, political geography as an essential, fundamental component of international studies. The…

  12. On Sufism, Sufi Group Study and Group Leadership.

    ERIC Educational Resources Information Center

    Einhorn, Jay

    1979-01-01

    Sufism is an ancient tradition of experiential human development. Sufi human development specialists utilize the group setting as a major study format. Comparison with group counseling might broaden perspectives on the possibilities and pitfalls of group process, and pinpoint several important issues relevant to group leadership. (Author)

  13. Three-dimensional Reconstruction of Peripheral Nerve Internal Fascicular Groups

    PubMed Central

    Zhong, Yingchun; Wang, Liping; Dong, Jianghui; Zhang, Yi; Luo, Peng; Qi, Jian; Liu, Xiaolin; Xian, Cory J.

    2015-01-01

    Peripheral nerves are important pathways for receiving afferent sensory impulses and sending out efferent motor instructions, as carried out by sensory nerve fibers and motor nerve fibers. It has remained a great challenge to functionally reconnect nerve internal fiber bundles (or fascicles) in nerve repair. One possible solution may be to establish a 3D nerve fascicle visualization system. This study described the key technology of 3D peripheral nerve fascicle reconstruction. Firstly, fixed nerve segments were embedded with position lines, cryostat-sectioned continuously, stained and imaged histologically. Position line cross-sections were identified using a trained support vector machine method, and the coordinates of their central pixels were obtained. Then, nerve section images were registered using the bilinear method, and edges of fascicles were extracted using an improved gradient vector flow snake method. Subsequently, fascicle types were identified automatically using the multi-directional gradient and second-order gradient method. Finally, a 3D virtual model of internal fascicles was obtained after section images were processed. This technique was successfully applied for 3D reconstruction for the median nerve of the hand-wrist and cubital fossa regions and the gastrocnemius nerve. This nerve internal fascicle 3D reconstruction technology would be helpful for aiding peripheral nerve repair and virtual surgery. PMID:26596642

  14. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    NASA Astrophysics Data System (ADS)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    The XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP), also known as the Group30 conference, took place in Ghent (Belgium) from Monday 14 to Friday 18 July 2014. The conference was organised by Ghent University (Department of Applied Mathematics, Computer Science and Statistics, and Department of Mathematical Analysis). The website http://www.group30.ugent.be is still available. The ICGTMP is one of the traditional conference series covering the most important topics of symmetry which are relevant to the interplay of present-day mathematics and physics. More than 40 years ago a group of enthusiasts, headed by H. Bacry of Marseille and A. Janner of Nijmegen, initiated a series of annual meetings with the aim to provide a common forum for scientists interested in group theoretical methods. At that time most of the participants belonged to two important communities: on the one hand solid state specialists, elementary particle theorists and phenomenologists, and on the other mathematicians eager to apply newly-discovered group and algebraic structures. The conference series has become a meeting point for scientists working at modelling physical phenomena through mathematical and numerical methods based on geometry and symmetry. It is considered as the oldest one among the conference series devoted to geometry and physics. It has been further broadened and diversified due to the successful applications of geometric and algebraic methods in life sciences and other areas. The first four meetings took place alternatively in Marseille and Nijmegen. Soon after, the conference acquired an international standing, especially following the 1975 colloquium in Nijmegen and the 1976 colloquium in Montreal. Since then it has been organized in many places around the world. It has become a bi-annual colloquium since 1990, the year it was organized in Moscow. This was the first time the colloquium took place in Belgium. There were 246 registered

  15. Learning Effects of an International Group Competition Project

    ERIC Educational Resources Information Center

    Akpinar, Murat; del Campo, Cristina; Eryarsoy, Enes

    2015-01-01

    This study investigates the effects of collaboration and competition on students' learning performance in a course of business statistics. The collaboration involved a simultaneously organised group competition project with analysis of real-life business problems among students. Students from the following schools participated: JAMK…

  16. 76 FR 55954 - Astralis Ltd., Cavit Sciences, Inc., Crystal International Travel Group, Inc., and Tasker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Astralis Ltd., Cavit Sciences, Inc., Crystal International Travel Group, Inc., and Tasker Products... accurate information concerning the securities of Crystal International Travel Group, Inc. because it...

  17. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    NASA Astrophysics Data System (ADS)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    The XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP), also known as the Group30 conference, took place in Ghent (Belgium) from Monday 14 to Friday 18 July 2014. The conference was organised by Ghent University (Department of Applied Mathematics, Computer Science and Statistics, and Department of Mathematical Analysis). The website http://www.group30.ugent.be is still available. The ICGTMP is one of the traditional conference series covering the most important topics of symmetry which are relevant to the interplay of present-day mathematics and physics. More than 40 years ago a group of enthusiasts, headed by H. Bacry of Marseille and A. Janner of Nijmegen, initiated a series of annual meetings with the aim to provide a common forum for scientists interested in group theoretical methods. At that time most of the participants belonged to two important communities: on the one hand solid state specialists, elementary particle theorists and phenomenologists, and on the other mathematicians eager to apply newly-discovered group and algebraic structures. The conference series has become a meeting point for scientists working at modelling physical phenomena through mathematical and numerical methods based on geometry and symmetry. It is considered as the oldest one among the conference series devoted to geometry and physics. It has been further broadened and diversified due to the successful applications of geometric and algebraic methods in life sciences and other areas. The first four meetings took place alternatively in Marseille and Nijmegen. Soon after, the conference acquired an international standing, especially following the 1975 colloquium in Nijmegen and the 1976 colloquium in Montreal. Since then it has been organized in many places around the world. It has become a bi-annual colloquium since 1990, the year it was organized in Moscow. This was the first time the colloquium took place in Belgium. There were 246 registered

  18. Design, conduct, and analyses of Breast International Group (BIG) 1-98: A randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer

    PubMed Central

    Giobbie-Hurder, Anita; Price, Karen N; Gelber, Richard D

    2010-01-01

    Background Aromatase inhibitors provide superior disease control when compared with tamoxifen as adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer. Purpose To present the design, history, and analytic challenges of the Breast International Group (BIG) 1-98 trial: an international, multicenter, randomized, double-blind, phase-III study comparing the aromatase inhibitor letrozole with tamoxifen in this clinical setting. Methods From 1998–2003, BIG 1-98 enrolled 8028 women to receive monotherapy with either tamoxifen or letrozole for 5 years, or sequential therapy of 2 years of one agent followed by 3 years of the other. Randomization to one of four treatment groups permitted two complementary analyses to be conducted several years apart. The first, reported in 2005, provided a head-to-head comparison of letrozole versus tamoxifen. Statistical power was increased by an enriched design, which included patients who were assigned sequential treatments until the time of the treatment switch. The second, reported in late 2008, used a conditional landmark approach to test the hypothesis that switching endocrine agents at approximately 2 years from randomization for patients who are disease-free is superior to continuing with the original agent. Results The 2005 analysis showed the superiority of letrozole compared with tamoxifen. The patients who were assigned tamoxifen alone were unblinded and offered the opportunity to switch to letrozole. Results from other trials increased the clinical relevance about whether or not to start treatment with letrozole or tamoxifen, and analysis plans were expanded to evaluate sequential versus single-agent strategies from randomization. Limitations Due to the unblinding of patients assigned tamoxifen alone, analysis of updated data will require ascertainment of the influence of selective crossover from tamoxifen to letrozole. Conclusions BIG 1-98 is an example of an enriched design, involving

  19. Comparing International Curriculum Systems: The International Instructional Systems Study

    ERIC Educational Resources Information Center

    Creese, Brian; Gonzalez, Alvaro; Isaacs, Tina

    2016-01-01

    This paper sets out the main findings of the International Instructional Systems Study (IISS), conducted by the UCL Institute of Education and funded by the Center on International Education Benchmarking (CIEB). The study examined the instructional systems and intended curricula of six "high performing" countries and two US states. The…

  20. Robotic, laparoscopic and open surgery for gastric cancer compared on surgical, clinical and oncological outcomes: a multi-institutional chart review. A study protocol of the International study group on Minimally Invasive surgery for GASTRIc Cancer—IMIGASTRIC

    PubMed Central

    Desiderio, Jacopo; Jiang, Zhi-Wei; Nguyen, Ninh T; Zhang, Shu; Reim, Daniel; Alimoglu, Orhan; Azagra, Juan-Santiago; Yu, Pei-Wu; Coburn, Natalie G; Qi, Feng; Jackson, Patrick G; Zang, Lu; Brower, Steven T; Kurokawa, Yukinori; Facy, Olivier; Tsujimoto, Hironori; Coratti, Andrea; Annecchiarico, Mario; Bazzocchi, Francesca; Avanzolini, Andrea; Gagniere, Johan; Pezet, Denis; Cianchi, Fabio; Badii, Benedetta; Novotny, Alexander; Eren, Tunc; Leblebici, Metin; Goergen, Martine; Zhang, Ben; Zhao, Yong-Liang; Liu, Tong; Al-Refaie, Waddah; Ma, Junjun; Takiguchi, Shuji; Lequeu, Jean-Baptiste; Trastulli, Stefano; Parisi, Amilcare

    2015-01-01

    Introduction Gastric cancer represents a great challenge for healthcare providers and requires a multidisciplinary treatment approach in which surgery plays a major role. Minimally invasive surgery has been progressively developed, first with the advent of laparoscopy and recently with the spread of robotic surgery, but a number of issues are currently being debated, including the limitations in performing an effective extended lymph node dissection, the real advantages of robotic systems, the role of laparoscopy for Advanced Gastric Cancer, the reproducibility of a total intracorporeal technique and the oncological results achievable during long-term follow-up. Methods and analysis A multi-institutional international database will be established to evaluate the role of robotic, laparoscopic and open approaches in gastric cancer, comprising of information regarding surgical, clinical and oncological features. A chart review will be conducted to enter data of participants with gastric cancer, previously treated at the participating institutions. The database is the first of its kind, through an international electronic submission system and a HIPPA protected real time data repository from high volume gastric cancer centres. Ethics and dissemination This study is conducted in compliance with ethical principles originating from the Helsinki Declaration, within the guidelines of Good Clinical Practice and relevant laws/regulations. A multicentre study with a large number of patients will permit further investigation of the safety and efficacy as well as the long-term outcomes of robotic, laparoscopic and open approaches for the management of gastric cancer. Trial registration number NCT02325453; Pre-results. PMID:26482769

  1. Report from International Lunar Exploration Working Group (ILEWG) to COSPAR

    NASA Astrophysics Data System (ADS)

    Foing, Bernard H.

    inputs to future missions, including a gap analysis of needed measurements. Highly resolved global data sets are required. Autonomous landing and hazard avoidance will depend on the best topographic map of the Moon, achievable by combining shared data. - New topics such as life sciences, partial gravity processes on the Moon should be followed in relation to future exploration needs.” http://sci.esa.int/ilewg/ http://sci.esa.int/ilewg/47170-gluc-iceum11-beijing-2010lunar-declaration/ References: [1] 1st International Lunar Workshop, Balsiger H. et al., Editors, European Space Agency, 1994. ESA-SP-1170. [2] 2nd International Lunar Workshop, Kyoto, H. Mizutani, editor, Japan Space Forum Publisher, 1997. [3] 3rd International Lunar Workshop, Moscow 1998, E. Galimov, editor. [4] ICEUM4, ESTEC, 2000, ESA SP-462, B.H. Foing & M. Perry, editors. [5] ICEUM5, Hawaii Nov 2003, Durst S.M. et al, Editors, Vol 108, 1-576 pp, Science and Technology Series, American Astronautical Society, 2004. [6] ICEUM6, Udaipur 2004, Bhandari N., Editor, Journal Earth Sys-tem Science, India, 114, No6, Dec 2005, pp. 573-841. [7] ICEUM7, Toronto Sept 2005, sci.esa.int/ilewg. [8] ICEUM8, Beijing July 2006, Journal of Chinese Society of Astronautics, Vol. 28 Sup., 2007, Ji W., Editor. [9] ICEUM9, Sorrento, Italy, Foing B., Espinasse S., Kosters G., Editors. http://sci.esa.int/iceum9, Dec. 2007), [11] Ehrenfreund, P., Foing, B.H., Cellino, A. Editors, The Moon and Near Earth Objects, ASR Vol 37, 1, 2006. [12] Foing, B.H. et al editors, 'Astronomy and Space Science from the Moon', ASR 14, 6, 1994. [13] Ip W.-H., Foing, B.H., Masson Ph.L., editors, The Moon and Mars, ASR Vol 23, 11, 1999. [14] Foing, B.H. et al, editor, Lunar Exploration, Planetary and Space Science, Vol 50, 14-15, 2002. [15] Foing, B.H., Heather, D. editors, 'Lunar Exploration 2000', ASR Vol 30, Nr 8, 2002. [16] Huntress, W. et al 'The next steps in exploring deep space - A cosmic study by the IAA', Acta Astronautica, Vol 58, Issues 6

  2. Group Performance in Information Systems Project Groups: An Empirical Study

    ERIC Educational Resources Information Center

    Bahli, Bouchaib; Buyukkurt, Meral Demirbag

    2005-01-01

    The importance of teamwork in Information Systems Development (ISD) practice and education has been acknowledged but not studied extensively to date. This paper tests a model of how groups participating in ISD projects perform and examines the relationships between some antecedents of this performance based on group research theory well…

  3. Results of a Quality Assurance Review of External Beam Radiation Therapy in the International Society of Paediatric Oncology (Europe) Neuroblastoma Group's High-risk Neuroblastoma Trial: A SIOPEN Study

    SciTech Connect

    Gaze, Mark N.; Boterberg, Tom; Dieckmann, Karin; Hoermann, Marcus; Gains, Jennifer E.; Sullivan, Kevin P.; Ladenstein, Ruth

    2013-01-01

    Purpose: Radiation therapy is important for local control in neuroblastoma. This study reviewed the compliance of plans with the radiation therapy guidelines of the International Society of Paediatric Oncology (Europe) Neuroblastoma Group (SIOPEN) High-Risk Trial protocol. Methods and Materials: The SIOPEN trial central electronic database has sections to record diagnostic imaging and radiation therapy planning data. Individual centers may upload data remotely, but not all centers involved in the trial chose to use this system. A quality scoring system was devised based on how well the radiation therapy plan matched the protocol guidelines, to what extent deviations were justified, and whether adverse effects may result. Central review of radiation therapy planning was undertaken retrospectively in 100 patients for whom complete diagnostic and treatment sets were available. Data were reviewed and compared against protocol guidelines by an international team of radiation oncologists and radiologists. For each patient in the sample, the central review team assigned a quality assurance score. Results: It was found that in 48% of patients there was full compliance with protocol requirements. In 29%, there were deviations for justifiable reasons with no likely long-term adverse effects resulting. In 5%, deviations had occurred for justifiable reasons, but that might result in adverse effects. In 1%, there was a deviation with no discernible justification, which would not lead to long-term adverse events. In 17%, unjustified deviations were noted, with a risk of an adverse outcome resulting. Conclusions: Owing to concern over the proportion of patients in whom unjustified deviations were observed, a protocol amendment has been issued. This offers the opportunity for central review of radiation therapy plans before the start of treatment and the treating clinician a chance to modify plans.

  4. A prognostic model to predict survival in 867 World Health Organization-defined essential thrombocythemia at diagnosis: a study by the International Working Group on Myelofibrosis Research and Treatment.

    PubMed

    Passamonti, Francesco; Thiele, Jürgen; Girodon, Francois; Rumi, Elisa; Carobbio, Alessandra; Gisslinger, Heinz; Kvasnicka, Hans Michael; Ruggeri, Marco; Randi, Maria Luigia; Gangat, Naseema; Vannucchi, Alessandro Maria; Gianatti, Andrea; Gisslinger, Bettina; Müllauer, Leonhard; Rodeghiero, Francesco; d'Amore, Emanuele S G; Bertozzi, Irene; Hanson, Curtis A; Boveri, Emanuela; Marino, Filippo; Maffioli, Margherita; Caramazza, Domenica; Antonioli, Elisabetta; Carrai, Valentina; Buxhofer-Ausch, Veronika; Pascutto, Cristiana; Cazzola, Mario; Barbui, Tiziano; Tefferi, Ayalew

    2012-08-01

    Diagnosis of essential thrombocythemia (ET) has been updated in the last World Health Organization (WHO) classification. We developed a prognostic model to predict survival at diagnosis, named IPSET (International Prognostic Score for ET), studying patients with WHO-defined ET. Age 60 years or older, leukocyte count ≥ 11 × 10(9)/L, and prior thrombosis significantly affected survival, by multivariable Cox regression. On the basis of the hazard ratio, we assigned 2 points to age and 1 each to leukocyte count and thrombosis. So, the IPSET model allocated 867 patients into 3 risk categories with significantly different survival: low (sum of points = 0; median survival not reached), intermediate (sum = 1-2; median survival 24.5 years), and high (sum = 3-4, median survival 13.8 years). The IPSET model was further validated in 2 independent cohorts including 132 WHO-defined ET and 234 Polycythemia Vera Study Group-defined ET patients. The IPSET model was able to predict the occurrence of thrombosis, and not to predict post-ET myelofibrosis. In conclusion, IPSET, based on age ≥ 60 years, leukocyte count ≥ 11 × 10(9)/L, and history of thrombosis allows prognostic assessment of WHO-defined ET and the validation process makes IPSET applicable in all patients phenotypically appearing as ET.

  5. Spectroscopic investigation of the vibrational quasi-continuum arising from internal rotation of a methyl group

    SciTech Connect

    Hougen, J.T.

    1993-12-01

    The goal of this project is to use spectroscopic techniques to investigate in detail phenomena involving the vibrational quasi-continuum in a simple physical system. Acetaldehyde was chosen for the study because: (i) methyl groups have been suggested to be important promotors of intramolecular vibrational relaxation, (ii) the internal rotation of a methyl group is an easily describle large-amplitude motion, which should retain its simple character even at high levels of excitation, and (iii) the aldehyde carbonyl group offers the possibility of both vibrational and electronic probing. The present investigation of the ground electronic state has three parts: (1) understanding the {open_quotes}isolated{close_quotes} internal-rotation motion below, at, and above the top of the torsional barrier, (2) understanding in detail traditional (bond stretching and bending) vibrational fundamental and overtone states, and (3) understanding interactions involving states with multiquantum excitations of at least one of these two kinds of motion.

  6. Internal consistency of the self-reporting questionnaire-20 in occupational groups

    PubMed Central

    Santos, Kionna Oliveira Bernardes; Carvalho, Fernando Martins; de Araújo, Tânia Maria

    2016-01-01

    ABSTRACT OBJECTIVE To assess the internal consistency of the measurements of the Self-Reporting Questionnaire (SRQ-20) in different occupational groups. METHODS A validation study was conducted with data from four surveys with groups of workers, using similar methods. A total of 9,959 workers were studied. In all surveys, the common mental disorders were assessed via SRQ-20. The internal consistency considered the items belonging to dimensions extracted by tetrachoric factor analysis for each study. Item homogeneity assessment compared estimates of Cronbach’s alpha (KD-20), the alpha applied to a tetrachoric correlation matrix and stratified Cronbach’s alpha. RESULTS The SRQ-20 dimensions showed adequate values, considering the reference parameters. The internal consistency of the instrument items, assessed by stratified Cronbach’s alpha, was high (> 0.80) in the four studies. CONCLUSIONS The SRQ-20 showed good internal consistency in the professional categories evaluated. However, there is still a need for studies using alternative methods and additional information able to refine the accuracy of latent variable measurement instruments, as in the case of common mental disorders. PMID:27007682

  7. Internal psychosomatic medicine within the German Diagnosis Related Groups System

    PubMed Central

    Häuser, Winfried; Zimmer, Christoph; Wilhelm, Ruth; Klein, Walter; Krause-Wichmann, Daniel

    2004-01-01

    A model calculation was used to assess whether the G-DRG version 1.0 sufficiently represents integrated internal psychosomatic treatment of patients with psychosomatic disorders in relation to diagnosis and resource consumption. The DRGs of the Major Diagnostic Category "Mental Diseases" of the German DRG calculation sample 1.0 (diagnoses, procedures, cost weights) were analyzed. In a division of psychosomatic medicine within a general internal department, proceeds regarding 241 patients treated between 01 Jan and 31 Dec 2002, calculated according to the G-DRG version 1.0, were compared to the costs accrued. The G-DRG version 1.0 includes 7 DRGs of psychosomatic disorders in internal medicine (excluding disorders due to substance abuse). Assuming a base rate of € 2,900, the total proceeds of the G-DRG Version 1.0 exceeded the costs (+ € 57,971 /year). PMID:19742057

  8. Cerulean Warbler Technical Group: Coordinating international research and conservation

    USGS Publications Warehouse

    Dawson, D.K.; Wigley, T.B.; Keyser, P.D.

    2012-01-01

    Effective conservation for species of concern requires interchange and collaboration among conservationists and stakeholders. The Cerulean Warbler Technical Group (CWTG) is a consortium of biologists and managers from government agencies, non-governmental organizations, academia, and industry, who are dedicated to finding pro-active, science-based solutions for conservation of the Cerulean Warbler (Setophaga cerulea). Formed in the United States in 2001, CWTG’s scope soon broadened to address the species’ ecology and conservation on both the breeding and non-breeding ranges, in partnership with biologists from South and Central America. In 2004, CWTG launched the Cerulean Warbler Conservation Initiative, a set of activities aimed at addressing information and conservation needs for the species. These include (1) studies in the core breeding range to assess Cerulean Warbler response to forest management practices and to identify mined lands that could be reforested to benefit the species, (2) ecological and demographic studies on the winter range, and (3) surveys of Cerulean Warbler distribution on the breeding and winter ranges and during migration. A rangewide conservation action plan has been completed, along with a more detailed conservation plan for the non-breeding range. CWTG and partners now move forward with on-the-ground conservation, while still addressing unmet information needs.

  9. Adverse prognostic value of peritumoral vascular invasion: is it abrogated by adequate endocrine adjuvant therapy? Results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy for early breast cancer

    PubMed Central

    Viale, G.; Giobbie-Hurder, A.; Gusterson, B. A.; Maiorano, E.; Mastropasqua, M. G.; Sonzogni, A.; Mallon, E.; Colleoni, M.; Castiglione-Gertsch, M.; Regan, M. M.; Brown, R. W.; Golouh, R.; Crivellari, D.; Karlsson, P.; Öhlschlegel, C.; Gelber, R. D.; Goldhirsch, A.; Coates, A. S.

    2010-01-01

    Background: Peritumoral vascular invasion (PVI) may assist in assigning optimal adjuvant systemic therapy for women with early breast cancer. Patients and methods: Patients participated in two International Breast Cancer Study Group randomized trials testing chemoendocrine adjuvant therapies in premenopausal (trial VIII) or postmenopausal (trial IX) node-negative breast cancer. PVI was assessed by institutional pathologists and/or central review on hematoxylin–eosin-stained slides in 99% of patients (analysis cohort 2754 patients, median follow-up >9 years). Results: PVI, present in 23% of the tumors, was associated with higher grade tumors and larger tumor size (trial IX only). Presence of PVI increased locoregional and distant recurrence and was significantly associated with poorer disease-free survival. The adverse prognostic impact of PVI in trial VIII was limited to premenopausal patients with endocrine-responsive tumors randomized to therapies not containing goserelin, and conversely the beneficial effect of goserelin was limited to patients whose tumors showed PVI. In trial IX, all patients received tamoxifen: the adverse prognostic impact of PVI was limited to patients with receptor-negative tumors regardless of chemotherapy. Conclusion: Adequate endocrine adjuvant therapy appears to abrogate the adverse impact of PVI in node-negative disease, while PVI may identify patients who will benefit particularly from adjuvant therapy. PMID:19633051

  10. Is adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93.

    PubMed

    Pagani, Olivia; Gelber, Shari; Simoncini, Edda; Castiglione-Gertsch, Monica; Price, Karen N; Gelber, Richard D; Holmberg, Stig B; Crivellari, Diana; Collins, John; Lindtner, Jurij; Thürlimann, Beat; Fey, Martin F; Murray, Elizabeth; Forbes, John F; Coates, Alan S; Goldhirsch, Aron

    2009-08-01

    To compare the efficacy of chemoendocrine treatment with that of endocrine treatment (ET) alone for postmenopausal women with highly endocrine responsive breast cancer. In the International Breast Cancer Study Group (IBCSG) Trials VII and 12-93, postmenopausal women with node-positive, estrogen receptor (ER)-positive or ER-negative, operable breast cancer were randomized to receive either chemotherapy or endocrine therapy or combined chemoendocrine treatment. Results were analyzed overall in the cohort of 893 patients with endocrine-responsive disease, and according to prospectively defined categories of ER, age and nodal status. STEPP analyses assessed chemotherapy effect. The median follow-up was 13 years. Adding chemotherapy reduced the relative risk of a disease-free survival event by 19% (P = 0.02) compared with ET alone. STEPP analyses showed little effect of chemotherapy for tumors with high levels of ER expression (P = 0.07), or for the cohort with one positive node (P = 0.03). Chemotherapy significantly improves disease-free survival for postmenopausal women with endocrine-responsive breast cancer, but the magnitude of the effect is substantially attenuated if ER levels are high.

  11. DPHEP: From Study Group to Collaboration

    NASA Astrophysics Data System (ADS)

    Shiers, Jamie

    2014-06-01

    The international study group on data preservation in High Energy Physics, DPHEP, achieved a major milestone in 2012 with the publication of its eagerly anticipated large-scale report [1]. This document contains a description of data preservation activities from all major high energy physics collider-based experiments and laboratories. A central message of the report is that data preservation in HEP is not possible without long term investment in not only hardware but also human resources, and with this in mind DPHEP will evolve to a new collaboration structure in 2013. This paper describes the progress made since the publication of that report - shortly before CHEP 2012 - as well as the future working directions of the new collaboration.

  12. Group Counseling with International Students: Practical, Ethical, and Cultural Considerations

    ERIC Educational Resources Information Center

    Yakunina, Elena S.; Weigold, Ingrid K.; McCarthy, Alannah S.

    2011-01-01

    International students in higher education represent a diverse population with unique mental health needs. Foreign students commonly experience a host of adjustment issues, including acculturative stress, language difficulties, cultural misunderstandings, racial discrimination, and loss of social support. Despite their challenges, few…

  13. Effects of Group Work on English Communicative Competence of Chinese International Graduates in United States Institutions of Higher Education

    ERIC Educational Resources Information Center

    Xue, Mo

    2013-01-01

    This qualitative study investigated 14 Chinese international graduate students' lived experiences with group work and the effects of group work on their English communicative competence. The interview results showed that these participants' attitudes towards group work went through changes from initial inadaptation or dislike to later adaptation…

  14. Southeastern Cancer Study Group: breast cancer studies

    SciTech Connect

    Smalley, R.V.; Bartolucci, A.A.; Moore, M.

    1983-12-01

    During the past 10 years, the Southeastern Cancer Study Group (SECSG) has been engaged in one major adjuvant study and three major advanced disease studies for patients with adenocarcinoma of the breast. The adjuvant study is demonstrating that six months of adjuvant CMF is the therapeutic equivalent of 12 months and that post-operative irradiation is of no added therapeutic benefit. In patients with advanced disease, a low dose 5 drug combination of CMFVP induces more objective responses than single agent 5FU, but improves survival only for those patients with liver metastases when compared to the sequential use of the same 5 single agents. The three drug combination, CAF, utilizing doxorubicin, induces more objective responses than low dose CMFVP, but it does not improve overall survival. The addition of a phase active combination, CAMELEON, (i.e., sequentially alternating therapy) of CAF has not improved the duration of disease control and survival for patients with liver metastases, lymphangitic and nodular lung metastases compared to CAF. Aggressive combination chemotherapeutic approaches to patients with advanced disease provide better and longer disease and tumor control but only marginal improvements in overall survival. Adding additional agents to a maximally tolerable regimen has not improved the therapeutic outcome.

  15. Diagnostic effectiveness of 75 g oral glucose tolerance test for gestational diabetes in India based on the International Association of the Diabetes and Pregnancy Study Groups guidelines

    PubMed Central

    Nikhat, Irfana; Nirmalan, Praveen K

    2013-01-01

    Background To determine the diagnostic effectiveness of the fasting and one-hour plasma glucose levels for gestational diabetes (GDM) based on International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. Methods A Cross-sectional study that included 2348 pregnant women booked for antenatal care in 2011 at a tertiary care perinatal institute. Pregnant women underwent a 75 g oral glucose tolerance test (OGTT) between 24 and 28 weeks of gestation. Outcome measures include the incidence of GDM based on the IADPSG criteria and the diagnostic effectiveness of the recommended fasting and one-hour plasma glucose cut-off if used in isolation. Results The incidence of GDM was 21.81% (n = 520, 95% CI: 20.15, 23.57) with the IADPSG criteria. A fasting plasma glucose cut-off 92 mg/dL, in isolation, correctly classified 87.16% of GDM, with a specificity of 96.08%, clinically significant positive likelihood ratio (14.08) and a post-test probability of 79.71%. The one-hour 75 g test, in isolation, correctly classified 85.74% of GDM, had specificity of 99.68% and clinically significant positive likelihood ratio (111.12) and post-test probability of 96.87%. The application of the World Health Organization criteria would misclassify 11.91% (95% CI: 10.66, 13.26) of GDM as normal. Conclusions Additional testing of plasma glucose levels can be avoided for 18.25% (n = 435, 95% CI: 16.73, 19.84) if the IADPSG diagnostic criteria for GDM are applied with exit on a positive fasting or one-hour test result.

  16. Indigenous Studies as an International Field.

    ERIC Educational Resources Information Center

    Pino-Robles, Rodolfo

    This paper proposes the development of Indigenous Studies as an international field, both in the sense of advancing the discipline internationally, wherever there are Indigenous peoples, and in the sense of incorporating international perspectives into curricula. In Canada, Indigenous Studies has been and is still treated as something to be done…

  17. Breaking Cycles of Violence. A Work Group of the International Work Group on Death, Dying and Bereavement (IWG)

    ERIC Educational Resources Information Center

    Death Studies, 2005

    2005-01-01

    Violence begets violence and it is important to understand how cycles of violence are perpetuated if we are to find solutions to the global problems they present. A multi-disciplinary group of The International Work Group on Death, Dying and Bereavement has developed a model of the cyclical events that perpetuate violence at all levels including…

  18. IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS

    PubMed Central

    Moreno, Carlos; Lundblad, Arne; Kabat, Elvin A.

    1971-01-01

    The immunochemical properties of purified A1 and A2 glycoproteins have been compared to ascertain whether their antigenic determinants differ. Quantitative precipitin and complement-fixation studies using several anti-A sera as well as purified γG anti-A antibodies clearly showed a specificity difference. This was also supported by absorption studies: A2 substance specifically removed antibodies reacting with A2 substance leaving anti-A1 activity. A1 substance was more effective than A2 substance in dissolving an A1 anti-A1-specific precipitate. Purified γM anti-A hemolyzed A1 cells more readily than A2 cells. Inhibition studies using mono- and difucosyl type 2 A-active oligosaccharides showed that type 2 difucosyl receptors are present in A2 substance. The structural basis for the specificity difference between A1 and A2 would appear to be that A2 substances lack type 1 A determinants; this would account for the observed higher H and Leb activity in A2 substances. PMID:4104425

  19. International Consultation and Training on Group Work in South Asia

    ERIC Educational Resources Information Center

    Ibrahim, Farah A.

    2015-01-01

    This article presents a consultation and training for faculty and graduate students in South Asia under the auspices of the United Nations' Transfer of Knowledge Through Expatriate Nationals (TOKTEN) Program. It describes the development of a consultation relationship and training on group work. Needs assessments focusing on both cultural…

  20. Long-term results of International Breast Cancer Study Group Trial VIII: adjuvant chemotherapy plus goserelin compared with either therapy alone for premenopausal patients with node-negative breast cancer

    PubMed Central

    Karlsson, P.; Sun, Z.; Braun, D.; Price, K. N.; Castiglione-Gertsch, M.; Rabaglio, M.; Gelber, R. D.; Crivellari, D.; Collins, J.; Murray, E.; Zaman, K.; Colleoni, M.; Gusterson, B. A.; Viale, G.; Regan, M. M.; Coates, A. S.; Goldhirsch, A.

    2011-01-01

    Background: The International Breast Cancer Study Group Trial VIII compared long-term efficacy of endocrine therapy (goserelin), chemotherapy [cyclophosphamide, methotrexate and fluorouracil (CMF)], and chemoendocrine therapy (CMF followed by goserelin) for pre/perimenopausal women with lymph-node-negative breast cancer. Patients and methods: From 1990 to 1999, 1063 patients were randomized to receive (i) goserelin for 24 months (n = 346), (ii) six courses of ‘classical’ CMF (cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy (n = 360), or (iii) six courses of CMF plus 18 months goserelin (CMF→ goserelin; n = 357). Tumors were classified as estrogen receptor (ER) negative (19%), ER positive (80%), or ER unknown (1%); 19% of patients were younger than 40. Median follow-up was 12.1 years. Results: For the ER-positive cohort, sequential therapy provided a statistically significant benefit in disease-free survival (DFS) (12-year DFS = 77%) compared with CMF alone (69%) and goserelin alone (68%) (P = 0.04 for each comparison), due largely to the effect in younger patients. Patients with ER-negative tumors whose treatment included CMF had similar DFS (12-year DFS CMF = 67%; 12-year DFS CMF→ goserelin = 69%) compared with goserelin alone (12-year DFS = 61%, P= NS). Conclusions: For pre/perimenopausal women with lymph-node-negative ER-positive breast cancer, CMF followed by goserelin improved DFS in comparison with either modality alone. The improvement was the most pronounced in those aged below 40, suggesting an endocrine effect of prolonged CMF-induced amenorrhea. PMID:21325445

  1. Cognitive Behavioral Principles Within Group Mentoring: A Randomized Pilot Study

    PubMed Central

    JENT, JASON F.; NIEC, LARISSA N.

    2010-01-01

    This study evaluated the effectiveness of a group mentoring program that included components of empirically supported mentoring and cognitive behavioral techniques for children served at a community mental health center. Eighty-six 8- to 12-year-old children were randomly assigned to either group mentoring or a wait-list control group. Group mentoring significantly increased children’s reported social problem-solving skills and decreased parent-reported child externalizing and internalizing behavior problems after controlling for other concurrent mental health services. Attrition from the group mentoring program was notably low (7%) for children. The integration of a cognitive behavioral group mentoring program into children’s existing community mental health services may result in additional reductions in externalizing and internalizing behavior problems. PMID:20582243

  2. International Study of Marketing Education.

    ERIC Educational Resources Information Center

    Liander, Bertil, Ed.

    The International Marketing Federation (IMF), supported by the Marketing Science Institute, has surveyed IMF member countries and a representative scattering of others to determine the current state and future trends in marketing education. This volume presents the findings of the survey of 21 countries--Argentina, Australia, Canada, Denmark,…

  3. 76 FR 5832 - International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... November 17, 2010 (75 FR 70296). The negative determination of the TAA petition filed on behalf of workers at International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA... Employment and Training Administration International Business Machines (IBM), Software Group Business...

  4. Developing International Business Managers through International Study Visits to China

    ERIC Educational Resources Information Center

    Tang, Yiming; Rose, Susan

    2014-01-01

    Globalization is a key factor in the success of business organizations today, impacting many aspects of management performance. Understanding the global business environment has therefore become a key objective in the teaching of international business on Executive MBA programs. Drawing on the theory of experiential learning, this study examines…

  5. International Studies Seminar. Grade 9, First Semester.

    ERIC Educational Resources Information Center

    Girton, Robert

    This curriculum guide contains the grade 9 course content of the interdisciplinary International Studies Seminar, conducted at Withrow High School in Cincinnati, Ohio. The seminar, part of the school's International Studies Academy, is an alternative education program which emphasizes global studies as the core of its curriculum. The document…

  6. Stage IV and age over 45 years are the only prognostic factors of the International Prognostic Score for the outcome of advanced Hodgkin lymphoma in the Spanish Hodgkin Lymphoma Study Group series.

    PubMed

    Guisado-Vasco, Pablo; Arranz-Saez, Reyes; Canales, Miguel; Cánovas, Araceli; Garcia-Laraña, José; García-Sanz, Ramón; Lopez, Andrés; López, José Luis; Llanos, Marta; Moraleda, José Maria; Rodriguez, José; Rayón, Consuelo; Sabin, Pilar; Salar, Antonio; Marín-Niebla, Ana; Morente, Manuel; Sánchez-Godoy, Pedro; Tomás, José Francisco; Muriel, Alfonso; Abraira, Victor; Piris, Miguel A; Garcia, Juán F; Montalban, Carlos

    2012-05-01

    The International Prognostic Score (IPS) is the most widely used system to date for identifying risk groups for the outcome of patients with advanced Hodgkin lymphoma, although important limitations have been recognized. We analyzed the value of the IPS in a series of 311 patients with advanced classical Hodgkin lymphoma (cHL) (Ann Arbor stage III, IV or stage II with B symptoms and/or bulky masses) treated with first-line chemotherapy including adriamycin (adriamycin, bleomycin, vinblastine, dacarbazine [ABVD] or equivalent variants). In univariate and multivariate analyses, stage IV disease and age ≥ 45 years were the only factors with independent predictive significance for overall survival (OS) (p = 0.002 and p < 0.001, respectively). Stage IV was still significant for freedom from progression (FFP) (p = 0.001) and age ≥ 45 years was borderline significant (p = 0.058). IPS separates prognostic groups, as in the original publication, but this is mainly due to the high statistical significance of stage IV and age ≥ 45 years. Moreover, the combination of these two factors enables a simpler system to be constructed that separates groups with different FFP and OS. In conclusion, in our series, stage IV and age ≥ 45 years are the key prognostic factors for the outcome of advanced cHL.

  7. Abstracts from the 2016 Joint Meeting of the International Confocal Group (ICG), the International Dermoscopy Society (IDS), and the International Society for Digital Imaging of the Skin (ISDIS)

    PubMed Central

    2016-01-01

    What follows are the abstracts presented at the Joint Meeting of the International Confocal Group (ICG), the International Dermoscopy Society (IDS), and the International Society for Digital Imaging of the Skin (ISDIS). The meeting was held on March 5, 2016, in Washington, DC, USA, in conjunction with the annual meeting of the American Academy of Dermatology (Figure 1). The abstracts appear in the order in which they were presented.

  8. Literature Study Groups: Literacy Learning "with Legs"

    ERIC Educational Resources Information Center

    Parsons, Sue Christian; Mokhtari, Kouider; Yellin, David; Orwig, Ryan

    2011-01-01

    Literature study groups help promote critical thinking and improve reading skills. These groups, in general, are characterized by: (1) a flexible grouping--usually determined by a reader's choice of a given book at a given time; (2) participant-centered dialogue, where the teacher takes on the role of facilitator and expert participant rather than…

  9. Methyl Group Internal Rotation in the Pure Rotational Spectrum of 1,1-DIFLUOROACETONE

    NASA Astrophysics Data System (ADS)

    Grubbs, G. S. Grubbs, II; Cooke, S. A.; Groner, P.

    2011-06-01

    We have used chirped pulse Fourier transform microwave spectroscopy to record the pure rotational spectrum of the title molecule. The spectrum was doubled owing to the internal rotation of the methyl group. The spectrum has been assigned and two approaches to the spectral analysis have been performed. In the first case, the A and E components were fit separately using a principal axis method with the SPFIT code of Pickett. In the second case, the A and E states were fit simultaneously using the ERHAM code. For a satisfactory analysis of the spectral data it has been found that the choice of Hamiltonian reduction, i.e. Watson A or S, is very important. The barrier to the internal rotation has been determined to be 261.1(8) Cm-1 and it will be compared to that of acetone and other halogenated acetone species recently studied in our laboratory.

  10. 76 FR 54800 - International Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ..., Quality Assurance Group, San Jose, California; Notice of Negative Determination on Reconsideration On... Department's Notice was published in the Federal Register on February 2, 2011 (76 FR 5832). The subject.... The negative determination of the Trade Adjustment Assistance petition filed by a State of...

  11. The internal dynamics of environmental organizations: Movement interest groups, communal advocacy groups, and the policy process

    SciTech Connect

    Shaffer, M.B.

    1995-12-31

    How do the diverse qualities that movement organizations bring to the policy process affect the representation of particular interests? This question is explored by analyzing environmental organizations across the national, state, and local levels of the American political system. This article suggests that two types of social movement organizations exist: movement interest groups and communal advocacy groups. While this article does not provide direct evidence of the different policy capabilities of the two types of movement organizations, existing research is drawn upon to consider how each type might fare in the policy process. One approach suggests that centralized organizations with incremental goals are better equipped to attain policy success, while the other stresses the need for active member involvement to engage in disruptive politics. To fully assess these divergent views, this article presents a broad review and analysis of the literature.

  12. Division XII / Commission 46 / Program Group International Schools for Young Astronomers

    NASA Astrophysics Data System (ADS)

    De Greve, Jean-Pierre; Leung, Kam-Ching; Gerbaldi, Michèle

    The IAU Commission 46 Program Group International Schools for Young Astronomers (ISYA) was created in 1967 (Gerbaldi 2008). During the period 2006 till August 2008 two ISYAs took place, one in Malaysia and a second one in Turkey.

  13. Fostering Collaborative Teaching and Learning Scholarship through an International Writing Group Initiative

    ERIC Educational Resources Information Center

    Marquis, Elizabeth; Healey, Mick; Vine, Michelle

    2016-01-01

    The research presented here explored the experiences of participants in an international collaborative writing group (ICWG) initiative that ran in conjunction with the 2012 International Society for the Scholarship of Teaching and Learning (ISSoTL) conference. The ICWG sought to cultivate collaborative pedagogical scholarship by bringing together…

  14. Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database

    PubMed Central

    Liang, Guanghui; Gu, Zhitao; Fu, Jianhua; Shen, Yi; Wei, Yucheng; Tan, Lijie; Zhang, Peng; Han, Yongtao; Chen, Chun; Zhang, Renquan; Chen, Keneng; Chen, Hezhong; Liu, Yongyu; Cui, Youbing; Wang, Yun; Pang, Liewen; Yu, Zhentao; Zhou, Xinming; Liu, Yangchun; Liu, Yuan

    2016-01-01

    Background To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. Methods From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis. Cumulative incidence of recurrence (CIR) was assessed in R0 patients. Overall survival (OS) was evaluated both in an R0 resected cohort, as well as in all patients (any R status). CIR and OS were first analyzed according to the Masaoka-Koga staging system. Then, they were compared using the new TNM staging proposal. Results Based on Masaoka-Koga staging system, significant difference was detected in CIR among all stages. However, no survival difference was revealed between stage I and II, or between stage II and III. Stage IV carried the highest risk of recurrence and worst survival. According to the new TNM staging proposal, CIR in T1a was significantly lower comparing to all other T categories (P<0.05) and there is a significant difference in OS between T1a and T1b (P=0.004). T4 had the worst OS comparing to all other T categories. CIR and OS were significantly worse in N (+) than in N0 patients. Significant difference in CIR and OS was detected between M0 and M1b, but not between M0 and M1a. OS was almost always statistically different when comparison was made between stages I–IIIa and stages IIIb–IVb. However, no statistical difference could be detected among stages IIIb to IVb. Conclusions Compared with Masaoka-Koga staging, the IASLC/ITMIG TNM staging proposal not only describes the extent of tumor invasion but also provides information on lymphatic involvement and tumor dissemination

  15. Facebook Groups as LMS: A Case Study

    ERIC Educational Resources Information Center

    Meishar-Tal, Hagit; Kurtz, Gila; Pieterse, Efrat

    2012-01-01

    This paper describes a pilot study in using Facebook as an alternative to a learning management system (LMS). The paper reviews the current research on the use of Facebook in academia and analyzes the differences between a Facebook group and a regular LMS. The paper reports on a precedent-setting attempt to use a Facebook group as a course…

  16. NASA plan for international crustal dynamics studies

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The international activities being planned as part of the NASA geodynamics program are described. Methods of studying the Earth's crustal movements and deformation characteristics are discussed. The significance of the eventual formalations of earthquake predictions methods is also discussed.

  17. International and national expert group evaluations: biological/health effects of radiofrequency fields.

    PubMed

    Vijayalaxmi; Scarfi, Maria R

    2014-09-01

    The escalated use of various wireless communication devices, which emit non-ionizing radiofrequency (RF) fields, have raised concerns among the general public regarding the potential adverse effects on human health. During the last six decades, researchers have used different parameters to investigate the effects of in vitro and in vivo exposures of animals and humans or their cells to RF fields. Data reported in peer-reviewed scientific publications were contradictory: some indicated effects while others did not. International organizations have considered all of these data as well as the observations reported in human epidemiological investigations to set-up the guidelines or standards (based on the quality of published studies and the "weight of scientific evidence" approach) for RF exposures in occupationally exposed individuals and the general public. Scientists with relevant expertise in various countries have also considered the published data to provide the required scientific information for policy-makers to develop and disseminate authoritative health information to the general public regarding RF exposures. This paper is a compilation of the conclusions, on the biological effects of RF exposures, from various national and international expert groups, based on their analyses. In general, the expert groups suggested a reduction in exposure levels, precautionary approach, and further research. PMID:25211777

  18. International and National Expert Group Evaluations: Biological/Health Effects of Radiofrequency Fields

    PubMed Central

    Vijayalaxmi; Scarfi, Maria R.

    2014-01-01

    The escalated use of various wireless communication devices, which emit non-ionizing radiofrequency (RF) fields, have raised concerns among the general public regarding the potential adverse effects on human health. During the last six decades, researchers have used different parameters to investigate the effects of in vitro and in vivo exposures of animals and humans or their cells to RF fields. Data reported in peer-reviewed scientific publications were contradictory: some indicated effects while others did not. International organizations have considered all of these data as well as the observations reported in human epidemiological investigations to set-up the guidelines or standards (based on the quality of published studies and the “weight of scientific evidence” approach) for RF exposures in occupationally exposed individuals and the general public. Scientists with relevant expertise in various countries have also considered the published data to provide the required scientific information for policy-makers to develop and disseminate authoritative health information to the general public regarding RF exposures. This paper is a compilation of the conclusions, on the biological effects of RF exposures, from various national and international expert groups, based on their analyses. In general, the expert groups suggested a reduction in exposure levels, precautionary approach, and further research. PMID:25211777

  19. 75 FR 66796 - Pricewaterhousecoopers LLP (“PwC”), Internal Firm Services Client Account Administrators Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... Services, Atlanta, Georgia. The notice was published in the Federal Register on June 7, 2010 (75 FR 32224... Account Administrators Group Atlanta, GA; Amended Certification Regarding Eligibility To Apply for Worker... PricewaterhouseCoopers LLP (``PwC''), Internal Firm Services Client Account Administrator Group, Atlanta,...

  20. Hanford single-shell tank grouping study

    SciTech Connect

    Remund, K.M.; Anderson, C.M.; Simpson, B.C.

    1995-10-01

    A tank grouping study has been conducted to find Hanford single-shell tanks with similar waste properties. The limited sampling resources of the characterization program could be allocated more effectively by having a better understanding of the groups of tanks that have similar waste types. If meaningful groups of tanks can be identified, tank sampling requirements may be reduced, and the uncertainty of the characterization estimates may be narrowed. This tank grouping study considers the analytical sampling information and the historical information that is available for all single-shell tanks. The two primary sources of historical characterization estimates and information come from the Historical Tank Content Estimate (HTCE) Model and the Sort on Radioactive Waste Tanks (SORWT) Model. The sampling and historical information are used together to come up with meaningful groups of similar tanks. Based on the results of analyses presented in this report, credible tank grouping looks very promising. Some groups defined using historical information (HTCE and SORWT) correspond well with those based on analytical data alone.

  1. A Pilot Study Using the Group Environment Scale To Evaluate First-Year Resident Support Groups.

    ERIC Educational Resources Information Center

    Alexander, Dale; Skinner, Bron

    2002-01-01

    Tested a quantitative method for assessing medical resident support groups; used the Group Environment Scale to evaluate changes occurring during support group participation. Found that the GES is a useful tool for assessing intern support groups, and that the expressiveness, self-discovery, and anger and aggression subscales showed significant…

  2. Effectiveness of Group Activity Play Therapy on Internalizing and Externalizing Behavior Problems of Preadolescent Orphans in Uganda

    ERIC Educational Resources Information Center

    Ojiambo, Deborah

    2011-01-01

    This pilot study investigated the impact of group activity play therapy (GAPT) on displaced orphans aged 10 to 12 years living in a large children's village in Uganda. Teachers and housemothers identified 60 preadolescents exhibiting clinical levels of internalizing and externalizing behavior problems. The participants' ethnicity was…

  3. Item wording and internal consistency of a measure of cohesion: the group environment questionnaire.

    PubMed

    Eys, Mark A; Carron, Albert V; Bray, Steven R; Brawley, Lawrence R

    2007-06-01

    A common practice for counteracting response acquiescence in psychological measures has been to employ both negatively and positively worded items. However, previous research has highlighted that the reliability of measures can be affected by this practice (Spector, 1992). The purpose of the present study was to examine the effect that the presence of negatively worded items has on the internal reliability of the Group Environment Questionnaire (GEQ). Two samples (N = 276) were utilized, and participants were asked to complete the GEQ (original and revised) on separate occasions. Results demonstrated that the revised questionnaire (containing all positively worded items) had significantly higher Cronbach alpha values for three of the four dimensions of the GEQ. Implications, alternatives, and future directions are discussed.

  4. Rationale and design of the HepZero study: a prospective, multicenter, international, open, randomized, controlled clinical study with parallel groups comparing heparin-free dialysis with heparin-coated dialysis membrane (Evodial) versus standard care: study protocol for a randomized controlled trial

    PubMed Central

    2013-01-01

    Background Anticoagulation for chronic dialysis patients with contraindications to heparin administration is challenging. Current guidelines state that in patients with increased bleeding risks, strategies that can induce systemic anticoagulation should be avoided. Heparin-free dialysis using intermittent saline flushes is widely adopted as the method of choice for patients at risk of bleeding, although on-line blood predilution may also be used. A new dialyzer, Evodial (Gambro, Lund, Sweden), is grafted with unfractionated heparin during the manufacturing process and may allow safe and efficient heparin-free hemodialysis sessions. In the present trial, Evodial was compared to standard care with either saline flushes or blood predilution. Methods The HepZero study is the first international (seven countries), multicenter (10 centers), randomized, controlled, open-label, non-inferiority (and if applicable subsequently, superiority) trial with two parallel groups, comprising 252 end-stage renal disease patients treated by maintenance hemodialysis for at least 3 months and requiring heparin-free dialysis treatments. Patients will be treated during a maximum of three heparin-free dialysis treatments with either saline flushes or blood predilution (control group), or Evodial. The first heparin-free dialysis treatment will be considered successful when there is: no complete occlusion of air traps or dialyzer rendering dialysis impossible; no additional saline flushes to prevent clotting; no change of dialyzer or blood lines because of clotting; and no premature termination (early rinse-back) because of clotting. The primary objectives of the study are to determine the effectiveness of the Evodial dialyzer, compared with standard care in terms of successful treatments during the first heparin-free dialysis. If the non-inferiority of Evodial is demonstrated then the superiority of Evodial over standard care will be tested. The HepZero study results may have major clinical

  5. Students' Attitudes towards Culturally Mixed Groups on International Campuses: Impact of Participation in Diverse and Non-Diverse Groups

    ERIC Educational Resources Information Center

    Summers, Mark; Volet, Simone

    2008-01-01

    International campuses provide social forums to enhance students' intercultural competence, skills and confidence. Yet, despite multiple opportunities for social contact, the most typical pattern is one of minimal interaction between students from different cultural backgrounds. This study examined students' attitudes towards culturally mixed…

  6. Determination of HDV ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics

    PubMed Central

    Kellerman, Daniel L; Simmons, Kandice S; Pedraza, Mayra; Piccirilli, Joseph A; York, Darrin M; Harris, Michael E

    2015-01-01

    Biological catalysis involves interactions distant from the site of chemistry that can position the substrate for reaction. Catalysis of RNA 2′-O-transphosphorylation by the HDV ribozyme is sensitive to the identity of the N(-1) nucleotide flanking the reactive phosphoryl group. However, the interactions that affect the conformation of this position, and in turn the 2′O nucleophile, are unclear. Here, we describe the application of multiple substrate internal competition kinetic analyses to understand how the N(-1) nucleobase contributes to HDV catalysis, and to test the utility of this approach for RNA structure-function studies. Internal competition reactions containing all four substrate sequence variants at the N(-1) position in reactions using ribozyme active site mutations at A77 and A78 were used to test a proposed basepairing interaction. Mutants A78U, A78G and A79G retain significant catalytic activity, but do not alter the specificity for the N(-1) nucleobase. Effects of nucleobase analog substitutions at N(-1) indicate that U is preferred due to the ability to donate an H-bond in the Watson-Crick face and avoid minor groove steric clash. The results provide information essential for evaluating models of the HDV active site, and illustrate multiple-substrate kinetic analyses as a practical approach for characterizing structure-function relationships in RNA reactions. PMID:25937290

  7. Space station group activities habitability module study

    NASA Technical Reports Server (NTRS)

    Nixon, David

    1986-01-01

    This study explores and analyzes architectural design approaches for the interior of the Space Station Habitability Module (originally defined as Habitability Module 1 in Space Station Reference Configuration Decription, JSC-19989, August 1984). In the Research Phase, architectural program and habitability design guidelines are specified. In the Schematic Design Phase, a range of alternative concepts is described and illustrated with drawings, scale-model photographs and design analysis evaluations. Recommendations are presented on the internal architectural, configuration of the Space Station Habitability Module for such functions as the wardroom, galley, exercise facility, library and station control work station. The models show full design configurations for on-orbit performance.

  8. Report of the Public Cryptography Study Group.

    ERIC Educational Resources Information Center

    American Council on Education, Washington, DC.

    Concerns of the National Security Agency (NSA) that information contained in some articles about cryptography in learned and professional journals and in monographs might be inimical to the national security are addressed. The Public Cryptography Study Group, with one dissenting opinion, recommends that a voluntary system of prior review of…

  9. Metacognition and Group Differences: A Comparative Study

    ERIC Educational Resources Information Center

    Al-Hilawani, Yasser A.

    2014-01-01

    In this study, metacognition refers to performing visual analysis and discrimination of real life events and situations in naïve psychology, naïve physics, and naïve biology domains. It is used, along with measuring reaction time, to examine differences in the ability of four groups of students to select appropriate pictures that correspond with…

  10. THE COOPERATIVE INTERNATIONAL NEUROMUSCULAR RESEARCH GROUP DUCHENNE NATURAL HISTORY STUDY: GLUCOCORTICOID TREATMENT PRESERVES CLINICALLY MEANINGFUL FUNCTIONAL MILESTONES AND REDUCES RATE OF DISEASE PROGRESSION AS MEASURED BY MANUAL MUSCLE TESTING AND OTHER COMMONLY USED CLINICAL TRIAL OUTCOME MEASURES

    PubMed Central

    HENRICSON, ERIK K.; ABRESCH, R. TED; CNAAN, AVITAL; HU, FENGMING; DUONG, TINA; ARRIETA, ADRIENNE; HAN, JAY; ESCOLAR, DIANA M.; FLORENCE, JULAINE M.; CLEMENS, PAULA R.; HOFFMAN, ERIC P.; McDONALD, CRAIG M.

    2014-01-01

    Introduction Glucocorticoid (GC) therapy in Duchenne muscular dystrophy (DMD) has altered disease progression, necessitating contemporary natural history studies. Methods The Cooperative Neuromuscular Research Group (CINRG) DMD Natural History Study (DMD-NHS) enrolled 340 DMD males, ages 2–28 years. A comprehensive battery of measures was obtained. Results A novel composite functional “milestone” scale scale showed clinically meaningful mobility and upper limb abilities were significantly preserved in GC-treated adolescents/young adults. Manual muscle test (MMT)-based calculations of global strength showed that those patients <10 years of age treated with steroids declined by 0.4±0.39 MMT unit/year, compared with −0.4±0.39 MMT unit/year in historical steroid-naive subjects. Pulmonary function tests (PFTs) were relatively preserved in steroid-treated adolescents. The linearity and magnitude of decline in measures were affected by maturational changes and functional status. Conclusions In DMD, long-term use of GCs showed reduced strength loss and preserved functional capabilities and PFTs compared with previous natural history studies performed prior to the widespread use of GC therapy. PMID:23649481

  11. Expert group meetings in preparation for the 1984 International Conference on Population.

    PubMed

    1983-01-01

    4 expert group meetings were organized in preparation for the 1984 International Conference on Population for the purpose of discussing, assessing, and reviewing population issues to form a basis for documentation for the Conference. The meetings were as follows: Fertility and Family held in New Delhi, India, 5-11 January 1983; Population Distribution, Migration, and development held in Hammamet, Tunisia, 21-25 March 1983; Population, Resources, Environment, and Development held in Geneva, Switzerland, 25-29 April 1983; and Mortality and Health Policy held in Rome, Italy, 30 May to 3 June 1983. This discussion summarizes the last 3 meetings. Leon Tabah, Director of the UN Population Division pointed out in the keynote address of the expert group meeting on population distribution, migration, and development that the problems of population distribution and international migration did not receive sufficient attention at Bucharest. Themes covered at the meeting included: internal and international migration; conceptual approaches and patterns; migration and rural developement; migration, urbanization and development in both developing and developed countries; population distribution policies; and trends and policies in international migration in relation to development. Some of the views emphasized at the expert group meeting on population, resources, environment, and development are reviewed here, focusing on food and nutrition, employment and income distribution, health and education, resources and the environment, and integrated planning.

  12. Factorial and Item-Level Invariance of an Emotional Intelligence Scale across Groups of International Students

    ERIC Educational Resources Information Center

    Wang, Chuang; Kim, Do-Hong; Ng, Kok-Mun

    2012-01-01

    This study examined the factorial and item-level invariance of Wong and Law's emotional intelligence scale (WLEIS) in a sample of 375 international students in U.S. universities. Confirmatory factor analysis (CFA) and differential item functioning (DIF) analysis were employed at the test and item level, respectively. International students from…

  13. Development and Implementation of an International Counseling Outreach Effort in Bhutan: A Group Stage Conceptualization

    ERIC Educational Resources Information Center

    Guth, Lorraine J.; Lorelle, Sonya; Hinkle, J. Scott; Remley, Theodore P.

    2015-01-01

    This article highlights the development and implementation of an international counseling outreach program in Bhutan using a group stage conceptualization that includes the initial, transition, working, and final stages. The initial stage included a counseling initiative started by one of the queens as well as meetings with key leaders from the…

  14. Supporting the Thesis Writing Process of International Research Students through an Ongoing Writing Group

    ERIC Educational Resources Information Center

    Li, Linda Y.; Vandermensbrugghe, Joelle

    2011-01-01

    Evidence from research suggests writing support is particularly needed for international research students who have to tackle the challenges of thesis writing in English as their second language in Western academic settings. This article reports the development of an ongoing writing group to support the thesis writing process of international…

  15. The International Research Training Group (GRK532): Practicing Cross-Border Postgraduate Education

    ERIC Educational Resources Information Center

    Ehses, Markus; Veith, Michael

    2009-01-01

    In 1999, the International Research Training Group "GRK532" was founded as a pilot project for cross-border European postgraduate education along the German/French/Luxembourg borders. The project consists of an interdisciplinary research programme on synthesis, isolation and characterization of new materials accompanied by an ambitious continuous…

  16. Healing internalized racism: the role of a within-group sanctuary among people of African descent.

    PubMed

    Watts-Jones, Dee

    2002-01-01

    This article addresses the role of a "within-group" sanctuary for healing internalized racism among people of African descent. Internalized racism is distinguished from racism, juxtaposing the different experience of those who are oppressed and those who are privileged by racism. It is suggested that a context consisting exclusively of persons of African descent can provide an optimally safe space for initial stages of healing from internalized racism. The anxiety that a collective of African descendants can generate among whites, and subsequently among those of African descent, is examined by raising questions as to its possible meanings. Whites are encouraged to use their privilege to support such self-determined sanctuaries, rather than to obstruct them. People of African descent are encouraged to tolerate the anxiety that can be generated without "changing back," and to examine whether internalized racism is also implicated.

  17. The Second International Piping Integrity Research Group (IPIRG-2) program. Final report, October 1991--April 1996

    SciTech Connect

    Hopper, A.; Wilowski, G.; Scott, P.; Olson, R.

    1997-03-01

    The IPIRG-2 program was an international group program managed by the US NRC and funded by organizations from 15 nations. The emphasis of the IPIRG-2 program was the development of data to verify fracture analyses for cracked pipes and fittings subjected to dynamic/cyclic load histories typical of seismic events. The scope included: (1) the study of more complex dynamic/cyclic load histories, i.e., multi-frequency, variable amplitude, simulated seismic excitations, than those considered in the IPIRG-1 program, (2) crack sizes more typical of those considered in Leak-Before-Break (LBB) and in-service flaw evaluations, (3) through-wall-cracked pipe experiments which can be used to validate LBB-type fracture analyses, (4) cracks in and around pipe fittings, such as elbows, and (5) laboratory specimen and separate effect pipe experiments to provide better insight into the effects of dynamic and cyclic load histories. Also undertaken were an uncertainty analysis to identify the issues most important for LBB or in-service flaw evaluations, updating computer codes and databases, the development and conduct of a series of round-robin analyses, and analyst`s group meetings to provide a forum for nuclear piping experts from around the world to exchange information on the subject of pipe fracture technology. 17 refs., 104 figs., 41 tabs.

  18. Infrared spectra, methyl group structure and internal rotation in some methy - metal compounds

    NASA Astrophysics Data System (ADS)

    McKean, D. C.; McQuillan, G. P.; Torto, I.; Morrisson, A. R.

    1986-03-01

    Recent and current work on spectra in the CH and CD stretching regions of methyl-metal compounds is reviewed. Free internal rotation with CH force constant variation is found in MMe 3 (M  Ga, Tl) and MMe(CO) 5 (M  Mn, Re) compounds, studied in the gas phase. From solution measurements, no such rotation occurs in CpMMe(CO) 3 (M  Cr,Mo,W) and Cp 2MMe 2 (M  Ti,Zr,Hf), in most of which each methyl group contains two types of CH bond. In each d-subgroup, ν isCH decreases with increasing atomic number, while δ sCH 3 increases. The reverse occurs from Ga to Tl. r oCH values are predicted. There is evidence for the breakdown of the ν isCH/∠HCH correlation, especially in MeTiCl 3 where several features point to an unusual structure of the methyl group.

  19. Vietnamese International Student Repatriates: An Exploratory Study

    ERIC Educational Resources Information Center

    Le, Anh

    2014-01-01

    The main purpose of this qualitative study is to explore the experiences of Vietnamese international students who returned to Vietnam after graduation from a U.S. higher education institution (henceforth, the repatriates). Areas to be explored include the transitional period, perceptions of the relevance of the U.S. education to their current…

  20. International Relations, Social Studies: 6448.20.

    ERIC Educational Resources Information Center

    Coe, Rose Marie

    The forces affecting relations among nations as well as the effectiveness of decision making processes in international politics are examined and analyzed by 10th through 12th grade students in the elective quinmester course clustering around political studies. Goals emphasize helping students to understand state interaction and the variables…

  1. Families and Family Study in International Perspective

    ERIC Educational Resources Information Center

    Adams, Bert N.

    2004-01-01

    Many changes are occurring in the world's families. Some observers feel that the changes are destructive, whereas others see them as leading to new opportunities and understanding. Issues in international family studies include regional limitations and the various aspects of doing research cross-culturally. Knowledge regarding certain categories…

  2. Internal Consistency and Power When Comparing Total Scores from Two Groups.

    PubMed

    Barchard, Kimberly A; Brouwers, Vincent

    2016-01-01

    Researchers now know that when theoretical reliability increases, power can increase, decrease, or stay the same. However, no analytic research has examined the relationship of power to the most commonly used type of reliability-internal consistency-and the most commonly used measures of internal consistency, coefficient alpha and ICC(A,k). We examine the relationship between the power of independent samples t tests and internal consistency. We explicate the mathematical model upon which researchers usually calculate internal consistency, one in which total scores are calculated as the sum of observed scores on K measures. Using this model, we derive a new formula for effect size to show that power and internal consistency are influenced by many of the same parameters but not always in the same direction. Changing an experiment in one way (e.g., lengthening the measure) is likely to influence multiple parameters simultaneously; thus, there are no simple relationships between such changes and internal consistency or power. If researchers revise measures to increase internal consistency, this might not increase power. To increase power, researchers should increase sample size, select measures that assess areas where group differences are largest, and use more powerful statistical procedures (e.g., ANCOVA).

  3. Cretaceous Cogollo Group study - District Zulia Occidental

    SciTech Connect

    Lagazzi, R.; D`Antonio, G.; Hung, O.; Avila, A.

    1996-08-01

    The Cretaceous Cogollo Group, with over 1500 feet of platform carbonate and shale section, contains important oil accumulations in the west portion of the Maracaibo basin. However, after discovery of the major oil fields, all subsequent exploration and exploitation efforts led to disappointing results. This paper summarizes the study of the Cogollo Group in the Lake Maracaibo West Coast area, where light Cretaceous oil may have an impact on the total reserves. After integrating the Cogollo Group into the regional framework, the study focuses on the District Zulia Occidental, where over 40 deep wells either penetrated or tested the reservoir. Structural and stratigraphic descriptions are enriched by a significant amount of core and petrophysical data that leads to a better understanding of the reservoir layering and pore geometry. Well production performance and reservoir data are incorporated to the study as additional tools to determine the size of the oil accumulations. Finally, the study addresses the possibility of drilling slant or horizontal wells as a way to reduce the number of dry holes or marginal producers.

  4. 75 FR 66797 - PricewaterhouseCoopers LLP (“PwC”) Internal Firm Services Client Account Administrators Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... Employment and Training Administration PricewaterhouseCoopers LLP (``PwC'') Internal Firm Services Client... read PricewaterhouseCoopers LLP (``PwC''), Internal Firm Services Client Account Administrators Group... PricewaterhouseCoopers LLP (``PwC''), Internal Firm Services Client Account Administrators Group. The...

  5. 75 FR 36455 - SSE Telecom, Inc., Strategic Alliance Group, Inc., (n/k/a CruiseCam International, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... COMMISSION SSE Telecom, Inc., Strategic Alliance Group, Inc., (n/k/a CruiseCam International, Inc.), Stratasec, Inc., Superfly Advertising, Inc. (f/k/a Morlex, Inc.), SVI Media, Inc., Symons International Group, Inc., Synergy Renewable Resources, Inc., and Syntech International, Inc. (n/k/a Avalon...

  6. Canadian Mathematics Education Study Group = Groupe Canadien d'etude en didactique des mathematiques. Proceedings of the 1994 Annual Meeting (Regina, Saskatchewan, Canada, June 3-7, 1994).

    ERIC Educational Resources Information Center

    Quigley, Martyn, Ed.

    These proceedings contain papers from the 1994 annual meeting of the Canadian Mathematics Education Study Group. Papers are divided into the following sections: (1) invited lectures; (2) working groups; (3) topic groups; (4) ad hoc groups; and (5) reports on ICMI (International Committee on Mathematical Instruction) studies. Papers include: (1)…

  7. Group exposure for agoraphobics: a replication study.

    PubMed

    Teasdale, J D; Walsh, P A; Lancashire, M; Mathews, A M

    1977-02-01

    A replication study was conducted of the treatment of agoraphobics by exposure in cohesive groups, as described by Hand, Lamantagne and Marks (1974). The continuing improvement during follow-up, with consequent large overall improvement, reported in the original study was not replicated. However, the present study confirmed the usefulness of this procedure as a highly cost-efficient treatment. The assumed equivalence of the Gelder and Marks (1966) phobic rating scale and its modification by Watson and Marks (1971) was examined. Large discrepancies between the scales were obtained for initial assessments and change scores. It is suggested that there is a need for workers in this field to agree on methods of measurement. PMID:837039

  8. Assessment of Proficiency in Japanese as a Foreign Language. Conference Proceedings of an International Working Group Sponsored by the Asian Studies Council (Canberra, Australia, June 12-14, 1990).

    ERIC Educational Resources Information Center

    Wylie, Elaine, Ed.

    The proceedings of a working group conference on proficiency testing of Japanese as a second language contain a brief background paper distributed to conference invitees, a list of items included in the pre-conference portfolio, an advance organizer of potential discussion topics, a 77-item annotated list of bibliographies on second language…

  9. The International Dermatology Outcome Measures Group: formation of patient-centered outcome measures in dermatology.

    PubMed

    Gottlieb, Alice B; Levin, Adriane A; Armstrong, April W; Abernethy, April; Duffin, Kristina Callis; Bhushan, Reva; Garg, Amit; Merola, Joseph F; Maccarone, Mara; Christensen, Robin

    2015-02-01

    As quality standards are increasingly in demand throughout medicine, dermatology needs to establish outcome measures to quantify the effectiveness of treatments and providers. The International Dermatology Outcome Measures Group was established to address this need. Beginning with psoriasis, the group aims to create a tool considerate of patients and providers using the input of all relevant stakeholders in assessment of disease severity and response to treatment. Herein, we delineate the procedures through which consensus is being reached and the future directions of the project.

  10. International geomagnetic reference field 1980: a report by IAGA Division I working group.

    USGS Publications Warehouse

    Peddie, N.W.

    1982-01-01

    Describes the recommendations of the working group, which suggested additions to IGRF because of the cumulative effect of the inevitable uncertainties in the secular variation models which had led to unacceptable inaccuracies in the IGRF by the late 1970's. The recommendations were accepted by the International Association of Geomagnetism and Aeronomy on August 15, 1981 at the 4th Scientific Assembly, Edinburgh. An extended table sets out spherical harmonic coefficients of the IGRF 1980.-R.House

  11. Cross-year peer tutoring on internal medicine wards: results of a qualitative focus group analysis

    PubMed Central

    Krautter, Markus; Andreesen, Sven; Köhl-Hackert, Nadja; Hoffmann, Katja; Herzog, Wolfgang; Nikendei, Christoph

    2014-01-01

    Background Peer-assisted learning (PAL) has become a well-accepted teaching method within medical education. However, descriptions of on-ward PAL programs are rare. A focus group analysis of a newly established PAL program on an internal medicine ward was conducted to provide insights into PAL teaching from a student perspective. Purpose To provide insights into students’ experiences regarding their on-ward training with and without accompanying PAL tutors. Methods A total of N=168 medical students in their sixth semester participated in the investigation (intervention group: N=88; control group: N=80). The intervention group took part in the PAL program, while the control group received standard on-ward training. There were seven focus groups with N=43 participants (intervention group: four focus groups, N=28 participants; control group: three focus groups, N=15 participants). The discussions were analyzed using content analysis. Results The intervention group emphasized the role of the tutors as competent and well-trained teachers, most beneficial in supervising clinical skills. Tutors motivate students, help them to integrate into the ward team, and provide a non-fear-based working relationship whereby students’ anxiety regarding working on ward decreases. The control group had to rely on autodidactic learning strategies when neither supervising physicians nor final-year students were available. Conclusion On-ward PAL programs represent a particularly valuable tool for students’ support in training clinical competencies on ward. The tutor–student working alliance acts through its flat hierarchy. Nevertheless, tutors cannot represent an adequate substitute for experienced physicians. PMID:25278789

  12. Infrared and Raman studies of manganese dihydrogen phosphate dihydrate, Mn(H 2PO 4) 2·2H 2O. Part II: Region of the internal OH group vibrations

    NASA Astrophysics Data System (ADS)

    Koleva, V.; Stefov, V.; Cahil, A.; Najdoski, M.; Šoptrajanov, B.; Engelen, B.; Lutz, H. D.

    2009-02-01

    Infrared and Raman spectra of Mn(H 2PO 4) 2·2H 2O and of series of deuterated analogues recorded at room temperature (RT) and at the boiling temperature of liquid nitrogen (LNT) have been presented and analyzed with respect to the OH vibrations. In the OH stretching mode region ABC bands behaviour is observed in accordance with the structural data for presence of a short hydrogen bond (2.609 Å). It is presumed that the A band of the ABC trio most probably originates from the stretching OH vibrations of strongly hydrogen bonded POH(1) group, but the contribution of the second POH(2) group and the water molecule should be also considered. The strength of the four hydrogen bonds as deduced from the infrared wavenumbers of the isotopically isolated OD groups has been discussed in terms of the respective O···O distances, the hydrogen bond acceptor capability of the oxygen atoms, the hydrogen bond donor strength of the H 2PO 4 ions and water molecules and the hydrogen bond acceptor angles. The influence of the cooperative effect has been also analyzed.

  13. International Space Station Air Quality Assessed According to Toxicologically-Grouped Compounds

    NASA Technical Reports Server (NTRS)

    James, John T.; Limero, Tom; DeVera, Vanessa; Cheng, Patti; Hand, Jennifer; Macatangay, Ariel; Beck, Steve

    2009-01-01

    Scores of compounds are found in the International Space Station (ISS) atmospheric samples that are returned to the Johnson Space Center Toxicology Laboratory for analysis. Spacecraft Maximum Allowable Concentrations (SMACs) are set with the view that each compound is present as if there were no other compounds present. In order to apply SMACs to the interpretation of the analytical data, the toxicologist must employ some method of combining the potential effects of the aggregate of compounds found in the atmospheric samples. The simplest approach is to assume that each quantifiable compound has the potential for some effect in proportion to the applicable SMAC, and then add all the proportions. This simple paradigm disregards the fact that most compounds have potential to adversely affect only a few physiological systems, and their effects would be independent rather than additive. An improved approach to dealing with exposure to mixtures is to add the proportions only for compounds that adversely affect the same physiological system. For example, toxicants that cause respiratory irritation are separated from those that cause neurotoxicity or cardio-toxicity. Herein we analyze ISS air quality data according to toxicological groups with a view that this could be used for understanding any crew symptoms occurring at the time of the sample. In addition, this approach could be useful in post-flight longitudinal surveys where the flight surgeon may need to identify post-flight, follow-up medical studies because of on-orbit exposures that target specific physiological systems.

  14. Definition of a COPD self-management intervention: International Expert Group consensus.

    PubMed

    Effing, Tanja W; Vercoulen, Jan H; Bourbeau, Jean; Trappenburg, Jaap; Lenferink, Anke; Cafarella, Paul; Coultas, David; Meek, Paula; van der Valk, Paul; Bischoff, Erik W M A; Bucknall, Christine; Dewan, Naresh A; Early, Frances; Fan, Vincent; Frith, Peter; Janssen, Daisy J A; Mitchell, Katy; Morgan, Mike; Nici, Linda; Patel, Irem; Walters, Haydn; Rice, Kathryn L; Singh, Sally; Zuwallack, Richard; Benzo, Roberto; Goldstein, Roger; Partridge, Martyn R; van der Palen, Job

    2016-07-01

    There is an urgent need for consensus on what defines a chronic obstructive pulmonary disease (COPD) self-management intervention. We aimed to obtain consensus regarding the conceptual definition of a COPD self-management intervention by engaging an international panel of COPD self-management experts using Delphi technique features and an additional group meeting.In each consensus round the experts were asked to provide feedback on the proposed definition and to score their level of agreement (1=totally disagree; 5=totally agree). The information provided was used to modify the definition for the next consensus round. Thematic analysis was used for free text responses and descriptive statistics were used for agreement scores.In total, 28 experts participated. The consensus round response rate varied randomly over the five rounds (ranging from 48% (n=13) to 85% (n=23)), and mean definition agreement scores increased from 3.8 (round 1) to 4.8 (round 5) with an increasing percentage of experts allocating the highest score of 5 (round 1: 14% (n=3); round 5: 83% (n=19)).In this study we reached consensus regarding a conceptual definition of what should be a COPD self-management intervention, clarifying the requisites for such an intervention. Operationalisation of this conceptual definition in the near future will be an essential next step.

  15. Definition of a COPD self-management intervention: International Expert Group consensus.

    PubMed

    Effing, Tanja W; Vercoulen, Jan H; Bourbeau, Jean; Trappenburg, Jaap; Lenferink, Anke; Cafarella, Paul; Coultas, David; Meek, Paula; van der Valk, Paul; Bischoff, Erik W M A; Bucknall, Christine; Dewan, Naresh A; Early, Frances; Fan, Vincent; Frith, Peter; Janssen, Daisy J A; Mitchell, Katy; Morgan, Mike; Nici, Linda; Patel, Irem; Walters, Haydn; Rice, Kathryn L; Singh, Sally; Zuwallack, Richard; Benzo, Roberto; Goldstein, Roger; Partridge, Martyn R; van der Palen, Job

    2016-07-01

    There is an urgent need for consensus on what defines a chronic obstructive pulmonary disease (COPD) self-management intervention. We aimed to obtain consensus regarding the conceptual definition of a COPD self-management intervention by engaging an international panel of COPD self-management experts using Delphi technique features and an additional group meeting.In each consensus round the experts were asked to provide feedback on the proposed definition and to score their level of agreement (1=totally disagree; 5=totally agree). The information provided was used to modify the definition for the next consensus round. Thematic analysis was used for free text responses and descriptive statistics were used for agreement scores.In total, 28 experts participated. The consensus round response rate varied randomly over the five rounds (ranging from 48% (n=13) to 85% (n=23)), and mean definition agreement scores increased from 3.8 (round 1) to 4.8 (round 5) with an increasing percentage of experts allocating the highest score of 5 (round 1: 14% (n=3); round 5: 83% (n=19)).In this study we reached consensus regarding a conceptual definition of what should be a COPD self-management intervention, clarifying the requisites for such an intervention. Operationalisation of this conceptual definition in the near future will be an essential next step. PMID:27076595

  16. International Space Station Air Quality Assessed According to Toxicologically-Grouped Compounds

    NASA Technical Reports Server (NTRS)

    James, John T.; Limero, Thomas F.; Beck, Steve; Cheng, Patti F.; deVera, Vanessa J.; Hand, Jennifer; Macatangay, Ariel

    2010-01-01

    Scores of compounds are found in the International Space Station (ISS) atmospheric samples that are returned to the Johnson Space Center Toxicology Laboratory for analysis. Spacecraft Maximum Allowable Concentrations (SMACs) are set with the view that each compound is present as if there were no other compounds present. In order to apply SMACs to the interpretation of the analytical data, the toxicologist must employ some method of combining the potential effects of the aggregate of compounds found in the atmospheric samples. The simplest approach is to assume that each quantifiable compound has the potential for some effect in proportion to the applicable SMAC, and then add all the proportions. This simple paradigm disregards the fact that most compounds have potential to adversely affect only a few physiological systems, and their effects would be independent rather than additive. An improved approach to dealing with exposure to mixtures is to add the proportions only for compounds that adversely affect the same physiological system. For example, toxicants that cause respiratory irritation are separated from those that cause neurotoxicity or cardio-toxicity. Herein we analyze ISS air quality data according to toxicological groups with a view that this could be used for understanding any crew symptoms occurring at the time of the sample acquisition. In addition, this approach could be useful in post-flight longitudinal surveys where the flight surgeon may need to identify post-flight, follow-up medical studies because of on-orbit exposures that target specific physiological systems.

  17. Community Report and Recommendations from International Lunar Exploration Working Group (ILEWG)

    NASA Astrophysics Data System (ADS)

    Foing, Bernard H.

    2016-07-01

    The International Lunar Exploration Working Group (ILEWG) was established in April 1995 at a meeting in Hamburg, Germany. As established in its charter, this working group reports to COSPAR and is charged with developing an international strategy for the exploration of the Moon. It discusses coordination between missions, and a road map for future international lunar exploration and utilisation. It fosters information exchange or potential and real future lunar robotic and human missions, as well as for new scientific and exploration information about the Moon. We refer to COSPAR and ILEWG ICEUM and lunar conferences and declarations [1-18], present the GLUC/ICEUM11 declaration and give a report on ongoing relevant ILEWG community activities. ILEWG supported community forums, ILEWG EuroMoonMars field campaigns and technology validation activities, as well as Young Lunar Explorers events, and activities with broad stakeholders. We discuss how lunar missions SMART-1, Kaguya, Chang'E1&2, Chandrayaan-1, LCROSS, LRO, GRAIL, LADEE, Chang'E3 and upcoming missions contribute to lunar exploration objectives & roadmap towards the Moon Village. GLUC/ICEUM11 declaration: "467 International Lunar Explorers, registered delegates from 26 countries, assembled at GLUC Global Lunar Conference including the 11th ILEWG Conference on Exploration and Utilisation of the Moon (ICEUM11) in Beijing. The conference engaged scientists, engineers, enthusiast explorers, agencies and organisations in the discussion of recent results and activities and the review of plans for exploration. Space agencies representatives gave the latest reports on their current lunar activities and programmes. GLUC-ICEUM11 was a truly historical meeting that demonstrated the world-wide interest in lunar exploration, discovery, and science. More than 400 abstracts were accepted for oral and poster presentations in the technical sessions, organised in 32 sessions within 4 symposia: Science and Exploration; Technology

  18. Environmental studies group. Annual report for 1978

    SciTech Connect

    Hunt, D. C.; Hurley, J. D.

    1980-08-21

    Group projects included radioecological studies of aquatic and terrestrial systems, land management activities, foodstuff monitoring, dust transport studies including fugitive dust measurements and modeling, and several support programs involving evaluation of the plant's ambient air samplers and airborne tritium monitoring techniques. Some salient results from the several project reports include determination of an appropriate model for mechanically generated fugitive dust dispersion, a radionuclide inventory of Smart Ditch Pond (Pond D-1), a coefficient of community determination for two terrestrial sample plots on the plant site buffer zone, a natality and mortality rate determination for fawns in the plant deer herd (including one positive coyote-kill determination), inlet loss and filter paper collection efficiencies for the plant ambient air samplers, and differential tritium sampling measurements of the vapor in Building 771 stack effluent.

  19. How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model.

    PubMed

    Hameed, Imran; Riaz, Zahid; Arain, Ghulam A; Farooq, Omer

    2016-01-01

    The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail.

  20. How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model.

    PubMed

    Hameed, Imran; Riaz, Zahid; Arain, Ghulam A; Farooq, Omer

    2016-01-01

    The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail. PMID:27303345

  1. How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model

    PubMed Central

    Hameed, Imran; Riaz, Zahid; Arain, Ghulam A.; Farooq, Omer

    2016-01-01

    The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail. PMID:27303345

  2. Reports and recommendations from COSPAR Planetary Exploration Committee (PEX) & International Lunar Exploration Working Group (ILEWG)

    NASA Astrophysics Data System (ADS)

    Ehrenfreund, Pascale; Foing, Bernard

    2014-05-01

    In response to the growing importance of space exploration, the objectives of the COSPAR Panel on Exploration (PEX) are to provide high quality, independent science input to support the development of a global space exploration program while working to safeguard the scientific assets of solar system bodies. PEX engages with COSPAR Commissions and Panels, science foundations, IAA, IAF, UN bodies, and IISL to support in particular national and international space exploration working groups and the new era of planetary exploration. COSPAR's input, as gathered by PEX, is intended to express the consensus view of the international scientific community and should ultimately provide a series of guidelines to support future space exploration activities and cooperative efforts, leading to outstanding scientific discoveries, opportunities for innovation, strategic partnerships, technology progression, and inspiration for people of all ages and cultures worldwide. We shall focus on the lunar exploration aspects, where the COSPAR PEX is building on previous COSPAR, ILEWG and community conferences. An updated COSPAR PEX report is published and available online (Ehrenfreund P. et al, COSPAR planetary exploration panel report, http://www.gwu.edu/~spi/assets/COSPAR_PEX2012.pdf). We celebrate 20 years after the 1st International Conference on Exploration and Utilisation of the Moon at Beatenberg in June 1994. The International Lunar Exploration Working Group (ILEWG) was established the year after in April 1995 at an EGS meeting in Hamburg, Germany. As established in its charter, this working group reports to COSPAR and is charged with developing an international strategy for the exploration of the Moon (http://sci.esa.int/ilewg/ ). It discusses coordination between missions, and a road map for future international lunar exploration and utilisation. It fosters information exchange or potential and real future lunar robotic and human missions, as well as for new scientific and

  3. Computer calculation of the Van Vleck second moment for materials with internal rotation of spin groups

    NASA Astrophysics Data System (ADS)

    Goc, Roman

    2004-09-01

    This paper describes m2rc3, a program that calculates Van Vleck second moments for solids with internal rotation of molecules, ions or their structural parts. Only rotations about C 3 axes of symmetry are allowed, but up to 15 axes of rotation per crystallographic unit cell are permitted. The program is very useful in interpreting NMR measurements in solids. Program summaryTitle of the program: m2rc3 Catalogue number: ADUC Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADUC Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland License provisions: none Computers: Cray SV1, Cray T3E-900, PCs Installation: Poznań Supercomputing and Networking Center ( http://www.man.poznan.pl/pcss/public/main/index.html) and Faculty of Physics, A. Mickiewicz University, Poznań, Poland ( http://www.amu.edu.pl/welcome.html.en) Operating system under which program has been tested: UNICOS ver. 10.0.0.6 on Cray SV1; UNICOS/mk on Cray T3E-900; Windows98 and Windows XP on PCs. Programming language: FORTRAN 90 No. of lines in distributed program, including test data, etc.: 757 No. of bytes in distributed program, including test data, etc.: 9730 Distribution format: tar.gz Nature of physical problem: The NMR second moment reflects the strength of the nuclear magnetic dipole-dipole interaction in solids. This value can be extracted from the appropriate experiment and can be calculated on the basis of Van Vleck formula. The internal rotation of molecules or their parts averages this interaction decreasing the measured value of the NMR second moment. The analysis of the internal dynamics based on the NMR second moment measurements is as follows. The second moment is measured at different temperatures. On the other hand it is also calculated for different models and frequencies of this motion. Comparison of experimental and calculated values permits the building of the most probable model of internal dynamics in the studied material. The program described

  4. Human Factor Studies on a Mars Analogue During Crew 100b International Lunar Exploration Working Group EuroMoonMars Crew: Proposed New Approaches for Future Human Space and Interplanetary Missions.

    PubMed

    Rai, Balwant; Kaur, Jasdeep

    2012-11-01

    Knowing the risks, costs, and complexities associated with human missions to Mars, analogue research can be a great (low-risk) tool for exploring the challenges associated with the preparation for living, operating, and undertaking research in interplanetary missions. Short-duration analogue studies, such as those being accomplished at the Mars Desert Research Station (MDRS), offer the chance to study mission operations and human factors in a simulated environment, and therefore contribute to exploration of the Moon and Mars in planned future missions. This article is based upon previously published articles, abstracts, and presentations by a series of independent authors, human factor studies performed on mars analogue station by Crew 100B. The MDRS Crew 100B performed studies over 15 days providing a unique insight into human factor issues in simulated short-duration Mars mission. In this study, 15 human factors were evaluated and analyzed by subjective and objective means, and from the summary of results it was concluded that optimum health of an individual and the crew as a whole is a necessity in order to encourage and maintain high performance and the satisfaction of project goals.

  5. Human Factor Studies on a Mars Analogue During Crew 100b International Lunar Exploration Working Group EuroMoonMars Crew: Proposed New Approaches for Future Human Space and Interplanetary Missions

    PubMed Central

    Rai, Balwant; Kaur, Jasdeep

    2012-01-01

    Knowing the risks, costs, and complexities associated with human missions to Mars, analogue research can be a great (low-risk) tool for exploring the challenges associated with the preparation for living, operating, and undertaking research in interplanetary missions. Short-duration analogue studies, such as those being accomplished at the Mars Desert Research Station (MDRS), offer the chance to study mission operations and human factors in a simulated environment, and therefore contribute to exploration of the Moon and Mars in planned future missions. This article is based upon previously published articles, abstracts, and presentations by a series of independent authors, human factor studies performed on mars analogue station by Crew 100B. The MDRS Crew 100B performed studies over 15 days providing a unique insight into human factor issues in simulated short-duration Mars mission. In this study, 15 human factors were evaluated and analyzed by subjective and objective means, and from the summary of results it was concluded that optimum health of an individual and the crew as a whole is a necessity in order to encourage and maintain high performance and the satisfaction of project goals. PMID:23181225

  6. Human Factor Studies on a Mars Analogue During Crew 100b International Lunar Exploration Working Group EuroMoonMars Crew: Proposed New Approaches for Future Human Space and Interplanetary Missions.

    PubMed

    Rai, Balwant; Kaur, Jasdeep

    2012-11-01

    Knowing the risks, costs, and complexities associated with human missions to Mars, analogue research can be a great (low-risk) tool for exploring the challenges associated with the preparation for living, operating, and undertaking research in interplanetary missions. Short-duration analogue studies, such as those being accomplished at the Mars Desert Research Station (MDRS), offer the chance to study mission operations and human factors in a simulated environment, and therefore contribute to exploration of the Moon and Mars in planned future missions. This article is based upon previously published articles, abstracts, and presentations by a series of independent authors, human factor studies performed on mars analogue station by Crew 100B. The MDRS Crew 100B performed studies over 15 days providing a unique insight into human factor issues in simulated short-duration Mars mission. In this study, 15 human factors were evaluated and analyzed by subjective and objective means, and from the summary of results it was concluded that optimum health of an individual and the crew as a whole is a necessity in order to encourage and maintain high performance and the satisfaction of project goals. PMID:23181225

  7. Sector-Wide Approaches in Education: Issues for Donor Agencies Arising from Case Studies of Zambia and Mozambique. A Report from the Meeting of the International Working Group on Education (IWGE) (Lisbon, Portugal, November 19-21, 2001).

    ERIC Educational Resources Information Center

    Riddell, Abby

    This book contains two case studies--one from Zambia, one from Mozambique--of the implications for donors of pursuing sector-wide approaches (SWAps) in education. (A sector-wide approach is characterized as a sustained partnership led by national authorities involving different arms of government and, where relevant, donor agencies, with the goals…

  8. Professional Development in International Schools; Issues of Inclusion Identified by a Group of International School Teaching Assistants

    ERIC Educational Resources Information Center

    Tarry, Estelle; Cox, Anna

    2014-01-01

    With the growth in numbers of teaching assistants (TAs) in the UK, it has been identified through research carried out on behalf of the Council of British International Schools (COBIS) research that TAs in British international schools have specific and unmet training needs. Following the development of a course for TAs in international contexts,…

  9. Whom to Group with--A Bourdieusian Narrative Analysis of International Students in an Australian University

    ERIC Educational Resources Information Center

    Lin, Isadora Jung-Hsiu

    2012-01-01

    Increasing degree-seeking international students from affluent Asian countries, who use English as an additional language (EAL), have contributed to cultural and linguistic diversity in Australian universities. However, such diversity posed challenges in pedagogy and assessment. Drawn from a larger interview study, exploring what resources helped…

  10. IGORR-IV -- Proceedings of the fourth meeting of the International Group on Research Reactors

    SciTech Connect

    Rosenbalm, K.F.

    1995-12-31

    The International Group on Research Reactors was formed to facilitate the sharing of knowledge and experience among those institutions and individuals who are actively working to design, build, and promote new research reactors or to make significant upgrades to existing facilities. Twenty-nine papers were presented in five sessions and written versions of the papers or hard copies of the vugraphs used are published in these proceedings. The five sessions were: (1) Operating Research Reactors and Facility Upgrades; (2) Research Reactors in Design and Construction; (3) ANS Closeout Activities; (4) and (5) Research, Development, and Analysis Results.

  11. World disparities in risk definition and management of retinoblastoma: a report from the International Retinoblastoma Staging Working Group.

    PubMed

    Chantada, Guillermo L; Doz, François; Orjuela, Manuela; Qaddoumi, Ibrahim; Sitorus, Rita S; Kepak, Tomas; Furmanchuk, Anna; Castellanos, Mauricio; Sharma, Tarun; Chevez-Barrios, Patricia; Rodriguez-Galindo, Carlos

    2008-03-01

    Following from the publication of the International Retinoblastoma Staging System, an open internet discussion group was created at the www.cure4kids.org resource. The results of a survey distributed among participants are discussed. Although most patients with retinoblastoma were treated under prospective protocols, there was a wide variation in the definition of risk criteria and in the criteria for giving adjuvant chemotherapy following enucleation. Definition of high-risk histological features and the criteria for use of adjuvant therapy will be standardized in future studies. Internet meetings are a valuable mechanism for enabling participation from under-resourced countries in the development of cooperative studies. PMID:18059037

  12. Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group.

    PubMed

    Bartsch, H; Malaveille, C; Lowenfels, A B; Maisonneuve, P; Hautefeuille, A; Boyle, P

    1998-06-01

    Carcinogens present in cigarette smoke and diet have been associated with pancreatic cancer. We hypothesized that heterocyclic and aromatic amines implicated in these exposures could be involved as causative agents and that therefore genetic variation in enzymes metabolizing these carcinogens could modify the risk of developing malignant and benign pancreatic disease. The effect of the genetic polymorphism of acetyltransferases (NAT1) and NAT2), glutathione S-transferase M1 (GSTM1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) on the risk of pancreatic diseases (cancer, pancreatitis) was examined in a case-control study. PCR-based assays were used for genotype analysis of genomic DNA from whole blood cells. Samples collected from Caucasian patients with diagnosed pancreatic cancer (n = 81), with non-alcoholic (n = 41) and alcoholic pancreatitis (n = 73) and from asymptomatic control subjects (n = 78) were analysed. The prevalence of GSTM1 null genotype and of NAT2 fast and slow acetylator genotypes and the distribution of frequencies for NQO1 genotypes did not differ in subjects with pancreatic diseases vs controls. For NAT1 slow acetylators a non-significant excess (P = 0.18) was found among pancreatic cancer cases vs controls. There was a significant over-representation of the GSTM1 AB or B genotype in all pancreatic disease cases combined (OR = 2.6; P < 0.05). When concurrent controls were pooled with literature controls (n = 1427), OR was 1.4 (P = 0.08). The results of this study, requiring confirmation, suggest that the polymorphism of GSTM1 and NAT1 enzymes may be associated with a modest increase in susceptibility to pancreatic diseases.

  13. Leading a Successful International Sports Tour. Handbook for Leaders, Coaches and Managers of American Sports Groups and Teams Participating in International Athletic Exchanges.

    ERIC Educational Resources Information Center

    Department of State, Washington, DC.

    This is a handbook for leaders, coaches, and managers of American sports groups and teams participating in international athletic exchanges. Chapter one presents information on financing international sports tours. Chapter two covers the basic preparations necessary prior to going abroad. It includes information on tickets, passports, visas,…

  14. Factors Associated with Lack of Viral Suppression at Delivery among HAART-Naïve HIV-Positive Women in the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1025 Study

    PubMed Central

    Katz, Ingrid T.; Leister, Erin; Kacanek, Deborah; Hughes, Michael D.; Bardeguez, Arlene; Livingston, Elizabeth; Stek, Alice; Shapiro, David E.; Tuomala, Ruth

    2014-01-01

    Background High delivery maternal plasma HIV-1 RNA level (viral load, VL) is a risk factor for mother to child transmission and poor maternal health. Objective To identify factors associated with detectable VL at delivery despite initiation of highly active antiretroviral therapy (HAART) during pregnancy. Design Multicenter observational study. Setting 67 US AIDS clinical research sites. Patients HIV-1-positive pregnant women who initiated HAART during pregnancy. Measurements Descriptive summaries and associations between socio-demographic, HIV disease, treatment and pregnancy-related risk factors and detectable VL (>400copies/mL) at delivery. Results Between October 2002 and December 2011, 671 women met inclusion criteria and 13% had detectable VL at delivery. Factors associated with detectable VL included multiparity (16.4% vs 8% nulliparous, p=0.002), black non-Hispanic ethnicity (17.6% vs 6.6% Hispanic and 6.6% white/non-Hispanic, p<0.001), 11th grade or less education (17.6% vs.12.1% high school graduate and 6.7% some college or higher, p=0.013), and initiation of HAART in third trimester (23.9% vs 12.3% second and 8.6% first, p=0.002), timing of HIV diagnosis prior to current pregnancy (16.1% vs 11% during current pregnancy, p=0.051), and timing of first prenatal visit in 3rd trimester (33.3% vs 14.3% second and 10.5% first, p=0.002). Women who experienced treatment interruptions or reported poor medication adherence during pregnancy were more likely to have detectable VL at delivery than women with no interruptions or who reported better adherence. Limitations Women entered the study at varying times during pregnancy and for this and other reasons there was incomplete data on many covariates. Conclusions In this large U.S.-based cohort of HIV-1 positive women, 13% of women who initiated HAART during pregnancy had detectable VL at delivery. The timing of HAART initiation and prenatal care along with medication adherence during pregnancy appear to be

  15. International Cultural Immersion: Assessing the Influence of a Group Intervention on Intercultural Sensitivity for Counselor Trainees

    ERIC Educational Resources Information Center

    Barden, Sejal M.; Shannonhouse, Laura; Mobley, Keith

    2015-01-01

    Scholars (e.g., Bemak & Chung, 2004) underscore the need for group workers to be culturally sensitive. One group training strategy, cultural immersion, is often employed to develop cultural sensitivity. However, no studies have utilized quasi-experimental methodologies to assess differences in cultural sensitivity between trainees that immerse…

  16. Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report.

    PubMed

    Collard, Harold R; Ryerson, Christopher J; Corte, Tamera J; Jenkins, Gisli; Kondoh, Yasuhiro; Lederer, David J; Lee, Joyce S; Maher, Toby M; Wells, Athol U; Antoniou, Katerina M; Behr, Juergen; Brown, Kevin K; Cottin, Vincent; Flaherty, Kevin R; Fukuoka, Junya; Hansell, David M; Johkoh, Takeshi; Kaminski, Naftali; Kim, Dong Soon; Kolb, Martin; Lynch, David A; Myers, Jeffrey L; Raghu, Ganesh; Richeldi, Luca; Taniguchi, Hiroyuki; Martinez, Fernando J

    2016-08-01

    Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic. A literature review was conducted to identify all relevant English text publications and abstracts. Evidence-based updates on the epidemiology, etiology, risk factors, prognosis, and management of acute exacerbations of idiopathic pulmonary fibrosis are provided. Finally, to better reflect the current state of knowledge and improve the feasibility of future research into its etiology and treatment, the working group proposes a new conceptual framework for acute respiratory deterioration in idiopathic pulmonary fibrosis and a revised definition and diagnostic criteria for acute exacerbation of idiopathic pulmonary fibrosis.

  17. Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report.

    PubMed

    Collard, Harold R; Ryerson, Christopher J; Corte, Tamera J; Jenkins, Gisli; Kondoh, Yasuhiro; Lederer, David J; Lee, Joyce S; Maher, Toby M; Wells, Athol U; Antoniou, Katerina M; Behr, Juergen; Brown, Kevin K; Cottin, Vincent; Flaherty, Kevin R; Fukuoka, Junya; Hansell, David M; Johkoh, Takeshi; Kaminski, Naftali; Kim, Dong Soon; Kolb, Martin; Lynch, David A; Myers, Jeffrey L; Raghu, Ganesh; Richeldi, Luca; Taniguchi, Hiroyuki; Martinez, Fernando J

    2016-08-01

    Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic. A literature review was conducted to identify all relevant English text publications and abstracts. Evidence-based updates on the epidemiology, etiology, risk factors, prognosis, and management of acute exacerbations of idiopathic pulmonary fibrosis are provided. Finally, to better reflect the current state of knowledge and improve the feasibility of future research into its etiology and treatment, the working group proposes a new conceptual framework for acute respiratory deterioration in idiopathic pulmonary fibrosis and a revised definition and diagnostic criteria for acute exacerbation of idiopathic pulmonary fibrosis. PMID:27299520

  18. Differentiation and grouping of isolates of the Ganoderma lucidum complex by random amplified polymorphic DNA-PCR compared with grouping on the basis of internal transcribed spacer sequences.

    PubMed Central

    Hseu, R S; Wang, H H; Wang, H F; Moncalvo, J M

    1996-01-01

    Laccate polypores of the Ganoderma lucidum species complex are widespread white rot fungi of economic importance, but isolates cannot be identified by traditional taxonomic methods. Parsimony analysis of nucleotide sequences from the internal transcribed spacers (ITS) of the ribosomal gene (rDNA) distinguished six lineages in this species complex. Each ITS lineage may represent one or more putative species. While some isolates have identical ITS sequences, all of them could be clearly differentiated by genetic fingerprinting using random amplified polymorphic DNA (RAPD). To investigate the suitability of RAPD markers for taxonomic identification and grouping of isolates of the G. lucidum complex, RAPD fragments (RAPDs) were used as phenotypic characters in numerical and parsimony analyses. Results show that data from RAPDS do not distinguish the same clades as ITS data do. Groupings based on analysis of RAPD data were very sensitive to the choice of the grouping method used, and no consistent grouping of isolates could be proposed. However, analysis with RAPDs did resolve several robust terminal clades containing putatively conspecific isolates, suggesting that RAPDs might be helpful for systematics at the lower taxonomic levels that are unresolved by ITS sequence data. The limitations of RAPDs for systematics are briefly discussed. The conclusion of this study is that ITS sequences can be used to identify isolates of the G. lucidum complex, whereas RAPDs can be used to differentiate between isolates having identical ITS sequences. The practical implications of these results are briefly illustrated. PMID:8919797

  19. Beyond Group-Threat: Temporal Dynamics of International Migration and Linkages to Anti-Foreigner Sentiment

    PubMed Central

    DeWaard, Jack

    2014-01-01

    Prior research on the association between country-level patterns of international migration and anti-foreigner sentiment shows that larger foreign-born concentrations increase perceptions of threat among native-born individuals in receiving countries, which, in turn, give rise to exclusionary preferences. While recent work has assembled a list of limiting conditions that shape the strength of this association, I argue that these efforts are premature because they are based on a narrow way of conceptualising and measuring international migration. In contrast to concepts and measures privileging the size of the foreign-born population in receiving countries, I draw from other literatures highlighting the temporal dynamics of migration. In considering the role of the temporal dynamics of international migration in explaining variation in anti-foreigner sentiment, the question is whether and how the temporal stability of the foreign-born population in receiving countries matters. My results suggest that it does. The size and temporal stability of the foreign-born population play opposing roles in aggravating and ameliorating anti-foreigner sentiment, respectively, with each operating via different pathways at the individual level. My work thus breaks new ground by challenging existing theoretical constructs and operationalisations in the group-threat literature. PMID:26146481

  20. Internal medicine interns' and residents' pressure ulcer prevention and assessment attitudes and abilities: results of an exploratory study .

    PubMed

    Suen, Winnie; Parker, Victoria A; Harney, Lauren; Nevin, Siobhan; Jansen, Jane; Alexander, Linda; Berlowitz, Dan

    2012-04-01

     To evaluate and determine differences between attitudes of internal medicine interns and residents toward pressure ulcer (PU) prevention and to evaluate the interns' abilities to accurately identify wounds and stage PUs, an exploratory, quantitative study was conducted in a 639-bed, safety net academic center. Participants (21 internal medicine interns and 21 internal medicine residents) attending an educational session on PU prevention and care were eligible to participate. The 1-hour conference session was prepared and provided by a physician and wound care nurses. Before the lecture, participants were asked to complete an 11-question paper-and-pencil PU attitude survey. Following the lecture, they were asked to identify 11 wounds and stage PUs using the inpatient admission history and physical template used in the hospital's electronic medical record. An audience response system was used to record correct and incorrect responses. Nineteen (19) interns and 20 residents completed the survey. Twenty-one (21) interns successfully completed the wound assessment quiz. Descriptive statistics were used to examine the survey data and residents' and interns' average attitude scores were compared using independent group t-test. The results suggest that interns and residents have a positive attitude toward and are concerned about PU prevention. The significantly higher overall score among interns compared to residents (average 43.8 versus 38.8 respectively, P = 0.002) suggests interns have a more positive attitude than residents. Statistically significant differences between item scores showed that, compared to residents, interns perceived PU prevention to be more time-consuming (P = 0.01), less of a concern in practice (P = 0.02), and a lower priority than other areas of care (P = 0.003). Compared to residents, interns also were more likely to agree to with statement, "In my opinion, patients tend to not get as many pressure

  1. IGORR-1: Proceedings of the first meeting of the international group on research reactors

    SciTech Connect

    West, C.D.

    1990-05-01

    Many organizations, in several countries, are planning or implementing new or upgraded research reactor projects, but there has been no organized forum devoted entirely to discussion and exchange of information in this field. Over the past year or so, informal discussions resulted in widespread agreement that such a forum would serve a useful purpose. Accordingly, a proposal to form a group was submitted to the leading organizations known to be involved in projects to build or upgrade reactor facilities. Essentially all agreed to join in the formation of the International Group on Research Reactors (IGORR) and nominated a senior staff member to serve on its international organizing committee. The first IGORR meeting took place on February 28--March 2, 1990. It was very successful and well attended; some 52 scientists and engineers from 25 organizations in 10 countries participated in 2-1/2 days of open and informative presentations and discussions. Two workshop sessions offered opportunities for more detailed interaction among participants and resulted in identification of common R D needs, sources of data, and planned new facilities. Individual papers have been cataloged separately.

  2. National facilities study. Volume 4: Space operations facilities task group

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The principal objectives of the National Facilities Study (NFS) were to: (1) determine where U.S. facilities do not meet national aerospace needs; (2) define new facilities required to make U.S. capabilities 'world class' where such improvements are in the national interest; (3) define where consolidation and phase-out of existing facilities is appropriate; and (4) develop a long-term national plan for world-class facility acquisition and shared usage. The Space Operations Facilities Task Group defined discrete tasks to accomplish the above objectives within the scope of the study. An assessment of national space operations facilities was conducted to determine the nation's capability to meet the requirements of space operations during the next 30 years. The mission model used in the study to define facility requirements is described in Volume 3. Based on this model, the major focus of the Task Group was to identify any substantive overlap or underutilization of space operations facilities and to identify any facility shortfalls that would necessitate facility upgrades or new facilities. The focus of this initial study was directed toward facility recommendations related to consolidations, closures, enhancements, and upgrades considered necessary to efficiently and effectively support the baseline requirements model. Activities related to identifying facility needs or recommendations for enhancing U.S. international competitiveness and achieving world-class capability, where appropriate, were deferred to a subsequent study phase.

  3. An International Study of Research Misconduct Policies

    PubMed Central

    Resnik, David B.; Rasmussen, Lisa M.; Kissling, Grace E.

    2015-01-01

    Research misconduct is an international concern. Misconduct policies can play a crucial role in preventing and policing research misconduct, and many institutions have developed their own policies. While institutional policies play a key role in preventing and policing misconduct, national policies are also important to ensure consistent promulgation and enforcement of ethical standards. The purpose of this study was to obtain more information about research misconduct policies across the globe. We found that twenty-two of the top forty research and development funding countries (55%) had a national misconduct policy. Four countries (18.2%) are in the process of developing a policy, and four (18.2%) have a national research ethics code but no misconduct policy. All twenty-two countries (100%) with national policies included fabrication, falsification, and plagiarism in the definition of misconduct, but beyond that there was considerable diversity. Unethical authorship was mentioned in 54.6% of the misconduct definitions, followed by unethical publication practices (36.4%), conflict of interest mismanagement (36.4%), unethical peer review (31.8%), misconduct related to misconduct investigations (27.3%), poor record keeping (27.3%), other deception (27.3%), serious deviations (22.7%), violating confidentiality (22.7%), and human or animal research violations (22.7%). Having a national policy was positively associated with research and development funding ranking and intensiveness. To promote integrity in international research collaborations, countries should seek to harmonize and clarify misconduct definitions and develop procedures for adjudicating conflicts when harmonization does not occur. PMID:25928177

  4. An international study of research misconduct policies.

    PubMed

    Resnik, David B; Rasmussen, Lisa M; Kissling, Grace E

    2015-01-01

    Research misconduct is an international concern. Misconduct policies can play a crucial role in preventing and policing research misconduct, and many institutions have developed their own policies. While institutional policies play a key role in preventing and policing misconduct, national policies are also important to ensure consistent promulgation and enforcement of ethical standards. The purpose of this study was to obtain more information about research misconduct policies across the globe. We found that twenty-two of the top forty research and development funding countries (55%) had a national misconduct policy. Four countries (18.2%) are in the process of developing a policy, and four (18.2%) have a national research ethics code but no misconduct policy. All twenty-two countries (100%) with national policies included fabrication, falsification, and plagiarism in the definition of misconduct, but beyond that there was considerable diversity. Unethical authorship was mentioned in 54.6% of the misconduct definitions, followed by unethical publication practices (36.4%), conflict of interest mismanagement (36.4%), unethical peer review (31.8%), misconduct related to misconduct investigations (27.3%), poor record keeping (27.3%), other deception (27.3%), serious deviations (22.7%), violating confidentiality (22.7%), and human or animal research violations (22.7%). Having a national policy was positively associated with research and development funding ranking and intensiveness. To promote integrity in international research collaborations, countries should seek to harmonize and clarify misconduct definitions and develop procedures for adjudicating conflicts when harmonization does not occur. PMID:25928177

  5. Community Report and Recommendations from International Lunar Exploration Working Group (ILEWG)

    NASA Astrophysics Data System (ADS)

    Foing, Bernard H.

    2016-07-01

    The International Lunar Exploration Working Group (ILEWG) was established in April 1995 at a meeting in Hamburg, Germany. As established in its charter, this working group reports to COSPAR and is charged with developing an international strategy for the exploration of the Moon. It discusses coordination between missions, and a road map for future international lunar exploration and utilisation. It fosters information exchange or potential and real future lunar robotic and human missions, as well as for new scientific and exploration information about the Moon. We refer to COSPAR and ILEWG ICEUM and lunar conferences and declarations [1-18], present the GLUC/ICEUM11 declaration and give a report on ongoing relevant ILEWG community activities. ILEWG supported community forums, ILEWG EuroMoonMars field campaigns and technology validation activities, as well as Young Lunar Explorers events, and activities with broad stakeholders. We discuss how lunar missions SMART-1, Kaguya, Chang'E1&2, Chandrayaan-1, LCROSS, LRO, GRAIL, LADEE, Chang'E3 and upcoming missions contribute to lunar exploration objectives & roadmap towards the Moon Village. GLUC/ICEUM11 declaration: "467 International Lunar Explorers, registered delegates from 26 countries, assembled at GLUC Global Lunar Conference including the 11th ILEWG Conference on Exploration and Utilisation of the Moon (ICEUM11) in Beijing. The conference engaged scientists, engineers, enthusiast explorers, agencies and organisations in the discussion of recent results and activities and the review of plans for exploration. Space agencies representatives gave the latest reports on their current lunar activities and programmes. GLUC-ICEUM11 was a truly historical meeting that demonstrated the world-wide interest in lunar exploration, discovery, and science. More than 400 abstracts were accepted for oral and poster presentations in the technical sessions, organised in 32 sessions within 4 symposia: Science and Exploration; Technology

  6. Early retirement in an international perspective II: The international study.

    PubMed

    Olson-Frick, H

    1985-01-01

    Initially this article describes the development of disability pension and early retirement in the ages of forty and up till ordinary pensionable ages in nine industrialized countries from the year of 1965 to 1980. During the period there are rising parts of the populations in these pension forms in the countries. The background of this development is, however, somewhat unclear. The following explaining factors are amongst others taken up in the article: A growing sickness, a rising unemployment and especially among the rather old an increased tendency to withdraw from the labor market (for example depending on better pension benefits). The two last mentioned factors are, however, more probable than the first one because of lower mortality rates in the countries under the studied period. Finally the article is concluded with an example of a preparatory suggestion to solve the involved problems in the now existing pension schemes by knitting the pension payments to more productive ages in the future. PMID:2931390

  7. 76 FR 44491 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... amendment to the interim final rules (76 FR 37208) entitled, ``Group Health Plans and Health Insurance...-AQ66 Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals and... rule with request for comments entitled, ``Group Health Plans and Health Insurance Issuers:...

  8. Cognitive Distance, Absorptive Capacity and Group Rationality: A Simulation Study

    PubMed Central

    Curşeu, Petru Lucian; Krehel, Oleh; Evers, Joep H. M.; Muntean, Adrian

    2014-01-01

    We report the results of a simulation study in which we explore the joint effect of group absorptive capacity (as the average individual rationality of the group members) and cognitive distance (as the distance between the most rational group member and the rest of the group) on the emergence of collective rationality in groups. We start from empirical results reported in the literature on group rationality as collective group level competence and use data on real-life groups of four and five to validate a mathematical model. We then use this mathematical model to predict group level scores from a variety of possible group configurations (varying both in cognitive distance and average individual rationality). Our results show that both group competence and cognitive distance are necessary conditions for emergent group rationality. Group configurations, in which the groups become more rational than the most rational group member, are groups scoring low on cognitive distance and scoring high on absorptive capacity. PMID:25314132

  9. Association of American Geographers, Remote Sensing Specialty Group Special Issue of Geocarto International

    NASA Technical Reports Server (NTRS)

    Allen, Thomas R. (Editor); Emerson, Charles W. (Editor); Quattrochi, Dale A. (Editor); Arnold, James E. (Technical Monitor)

    2001-01-01

    This special issue continues the precedence of the Association of American Geographers (AAG), Remote Sensing Specialty Group (RSSG) for publishing selected articles in Geocarto International as a by-product from the AAG annual meeting. As editors, we issued earlier this year, a solicitation for papers to be published in a special issue of Geocarto International that were presented in RSSG-sponsored sessions at the 2001 AAG annual meeting held in New York City on February 27-March 3. Although not an absolute requisite for publication, the vast majority of the papers in this special issue were presented at this year's AAG meeting in New York. Other articles in this issue that were not part of a paper or poster session at the 2001 AAG meeting are authored by RSSG members. Under the auspices of the RSSG, this special Geocarto International issue provides even more compelling evidence of the inextricable linkage between remote sensing and geography. The papers in this special issue fall into four general themes: 1) Urban Analysis and Techniques for Urban Analysis; 2) Land Use/Land Cover Analysis; 3) Fire Modeling Assessment; and 4) Techniques. The first four papers herein are concerned with the use of remote sensing for analysis of urban areas, and with use or development of techniques to better characterize urban areas using remote sensing data. As the lead paper in this grouping, Rashed et al., examine the usage of spectral mixture analysis (SMA) for analyzing satellite imagery of urban areas as opposed to more 'standard' methods of classification. Here SMA has been applied to IRS-1C satellite multispectral imagery to extract measures that better describe the 'anatomy' of the greater Cairo, Egypt region. Following this paper, Weng and Lo describe how Landsat TM data have been used to monitor land cover types and to estimate biomass parameters within an urban environment. The research reported in this paper applies an integrated GIS (Geographic Information System

  10. Watching MOOCs Together: Investigating Co-Located MOOC Study Groups

    ERIC Educational Resources Information Center

    Li, Nan; Verma, Himanshu; Skevi, Afroditi; Zufferey, Guillaume; Blom, Jan; Dillenbourg, Pierre

    2014-01-01

    Research suggests that massive open online course (MOOC) students prefer to study in groups, and that social facilitation within the study groups may render the learning of difficult concepts a pleasing experience. We report on a longitudinal study that investigates how co-located study groups watch and study MOOC videos together. The study was…

  11. RECENT ACTIVITIES OF THE NUCLEAR SMUGGLING INTERNATIONAL TECHNICAL WORKING GROUP TO THWART ILLICIT TRAFFICKING

    SciTech Connect

    Smith, D K; Biro, T; Chartier, B; Mayer, K; Niemeyer, S; Thompson, P

    2007-10-25

    The Nuclear Smuggling International Technical Working Group (ITWG) is an informal association of nuclear forensic practitioners working in partnership with law enforcement, first responder, and nuclear regulatory professionals that cooperate to deter the illicit trafficking of nuclear materials. The objective of the ITWG is to advance the science of nuclear forensics and to provide a common approach and effective technical solutions to governments who request assistance. the ITWG was chartered in 1996 and since that time 30 nations and organizations have participated in 12 annual meetings and two analytical round-robin trials involving plutonium and highly enriched uranium. A third analytical round-robin as well as several table-top exercises are planned for later in 2007-2008. International interest in the ITWG has grown in over the past five years measured by the number of participants at its annual meetings. This growth has spawned the ITWG Nuclear Forensics Laboratories as a companion technical affiliate focusing exclusively on the scientific aspects of nuclear forensics and nuclear smuggling incident response.

  12. The Impact of Conflict on International Student Mobility: A Case Study of International Students Studying in Israel

    ERIC Educational Resources Information Center

    Ben-Tsur, Dalia

    2009-01-01

    This paper explores the impact of conflict on international student mobility. Through an examination of undergraduate, international students studying in Israel, this case study questions how and if a situation of ongoing violent conflict affects international student travel decisions to study in a host country. Contrary to assumptions of…

  13. 77 FR 36031 - ROK Entertainment Group, Inc., RussOil Corp., Tricell, Inc., Tunex International, Inc. (n/k/a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... Dental International Group, Inc.), and Wireless Age Communications, Inc.; Order of Suspension of Trading... securities of Wireless Age Communications, Inc. because it has not filed any periodic reports since...

  14. Computer Simulation in the Teaching of Translation and International Studies.

    ERIC Educational Resources Information Center

    Brecht, Richard D.; And Others

    1984-01-01

    Describes the National Simulation in International Studies and Translation Program which links international studies and foreign languages programs at a number of universities. This program provides a natural context for the exercise of translation for the language student and an authenticity of experience for students of international politics.…

  15. Internal Film Receiver systems assessment study

    SciTech Connect

    Anderson, J.V.

    1988-03-01

    This report documents SERI's Internal Film Receiver (IFR) design study and system assessment effort; and it compares the performance and economic potential of this system to conventional salt-in-tube receivers and to systems with the direct absorption receiver (DAR). SPECO, Inc., under contract to SERI, performed the receiver configuration work and their final report is included as Appendix A. The IFR is similar to the DAR in that both use films flowing over nearly vertical plates to absorb the solar energy. However, in the IFR the radiation strikes the outside of the absorber plate and the working fluid flows down the inside. The results of the system-level assessment indicate that the IFR concept has the potential to deliver levelized energy costs (LEC) on the order of 5%--7% lower than the salt-in-tube receiver. Although the potential economic benefits of the IFR are not as great as those for the DAR, which shows more than a 15% improvement in LEC over the salt-in-tube receiver system, this may be offset by the lower technical risks with the IFR. 3 refs., 2 figs., 7 tabs.

  16. 78 FR 53194 - Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities Division (TE/GE...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... Internal Revenue Service Advisory Group to the Internal Revenue Service Tax Exempt and Government Entities... Advisory Committee on Tax Exempt and Government Entities (ACT) will hold a public meeting on Thursday... Limited IRS Resources in the Tax Administration of Small Tax-Exempt Organizations Federal, State and...

  17. Childhood cancer and ethnic group in Britain: a United Kingdom children's Cancer Study Group (UKCCSG) study.

    PubMed Central

    Stiller, C. A.; McKinney, P. A.; Bunch, K. J.; Bailey, C. C.; Lewis, I. J.

    1991-01-01

    We present here the results of the largest study of childhood cancer and ethnic group in Britain, based on 7,658 children treated at paediatric oncology centres throughout the country. Incidence rates could not be calculated and so relative frequencies were analysed by the log-linear modelling method of Kaldor et al. (1990) with allowance made for regional variations in the ages and diagnostic groups of the children included in the study. Children of Asian (Indian sub-continent) and West Indian ethnic origin had similar patterns of incidence for acute lymphoblastic leukaemia to White Caucasians. There was a significant excess of Hodgkin's disease among Asian children compared with Caucasians with an estimated relative risk (RR) of 2.09; this excess was greatest in the 0-4 age group (RR = 6.67). There were significant deficits of Wilms' tumour and rhabdomyosarcoma among Asian children, each with a frequency around half that among Caucasians, whereas West Indians had a significant excess of Wilms' tumour (RR = 2.55). Asian and West Indian children each had a non-significant twofold RR for unilateral retinoblastoma. The results suggest that the incidence of childhood acute lymphoblastic leukaemia is associated with environmental determinants in the country of residence which are most likely to relate to lifestyle factors. The occurrence of retinoblastoma, Wilms' tumour and Hodgkin's disease in early childhood is apparently related more to ethnicity than to geographical location and may reflect genetic factors or environmental exposures specific to the lifestyle of particular ethnic groups. PMID:1654982

  18. Gender-based education during clerkships: a focus group study

    PubMed Central

    van Leerdam, Lotte; Rietveld, Lianne; Teunissen, Doreth; Lagro-Janssen, Antoine

    2014-01-01

    Objectives One of the goals of the medical master’s degree is for a student to become a gender-sensitive doctor by applying knowledge of gender differences in practice. This study aims to investigate, from the students’ perspective, whether gender medicine has been taught in daily practice during clerkship. Methods A focus group study was conducted among 29 medical students from Radboud University, Nijmegen, The Netherlands, who had just finished either their internal medicine or surgical clerkships. Data were analyzed in line with the principles of constant comparative analysis. Results Four focus groups were conducted with 29 participating students. Clinical teachers barely discuss gender differences during students’ clerkships. The students mentioned three main explanatory themes: insufficient knowledge; unawareness; and minor impact. As a result, students feel that they have insufficient competencies to become gender-sensitive doctors. Conclusion Medical students at our institution perceive that they have received limited exposure to gender-based education after completing two key clinical clerkships. All students feel that they have insufficient knowledge to become gender-sensitive doctors. They suppose that their clinical teachers have insufficient knowledge regarding gender sensitivity, are unaware of gender differences, and the students had the impression that gender is not regarded as an important issue. We suggest that the medical faculty should encourage clinical teachers to improve their knowledge and awareness of gender issues. PMID:24600301

  19. Internal NASA Study: NASAs Protoflight Research Initiative

    NASA Technical Reports Server (NTRS)

    Coan, Mary R.; Hirshorn, Steven R.; Moreland, Robert

    2015-01-01

    The NASA Protoflight Research Initiative is an internal NASA study conducted within the Office of the Chief Engineer to better understand the use of Protoflight within NASA. Extensive literature reviews and interviews with key NASA members with experience in both robotic and human spaceflight missions has resulted in three main conclusions and two observations. The first conclusion is that NASA's Protoflight method is not considered to be "prescriptive." The current policies and guidance allows each Program/Project to tailor the Protoflight approach to better meet their needs, goals and objectives. Second, Risk Management plays a key role in implementation of the Protoflight approach. Any deviations from full qualification will be based on the level of acceptable risk with guidance found in NPR 8705.4. Finally, over the past decade (2004 - 2014) only 6% of NASA's Protoflight missions and 6% of NASA's Full qualification missions experienced a publicly disclosed mission failure. In other words, the data indicates that the Protoflight approach, in and of it itself, does not increase the mission risk of in-flight failure. The first observation is that it would be beneficial to document the decision making process on the implementation and use of Protoflight. The second observation is that If a Project/Program chooses to use the Protoflight approach with relevant heritage, it is extremely important that the Program/Project Manager ensures that the current project's requirements falls within the heritage design, component, instrument and/or subsystem's requirements for both the planned and operational use, and that the documentation of the relevant heritage is comprehensive, sufficient and the decision well documented. To further benefit/inform this study, a recommendation to perform a deep dive into 30 missions with accessible data on their testing/verification methodology and decision process to research the differences between Protoflight and Full Qualification

  20. Integrated thermal treatment systems study. Internal review panel report

    SciTech Connect

    Cudahy, J.; Escarda, T.; Gimpel, R.

    1995-04-01

    The U.S. Department of Energy (DOE) Office of Technology Development (OTD) commissioned two studies to evaluate nineteen thermal treatment technologies for treatment of DOE mixed low-level waste. These studies were called the Integrated Thermal Treatment System (ITTS) Phase I and Phase II. With the help of the DOE Office of Environmental Management (EM) Mixed Waste Focus Group, OTD formed an ITTS Internal Review Panel to review and comment on the ITTS studies. This Panel was composed of scientists and engineers from throughout the DOE complex, the U.S. Environmental Protection Agency, the California EPA, and private experts. The Panel met from November 15-18, 1994 to review the ITTS studies and to make recommendations on the most promising thermal treatment systems for DOE mixed low-level wastes and on research and development necessary to prove the performance of the technologies. This report describes the findings and presents the recommendations of the Panel.

  1. International Students' Employment Search in the United States: A Phenomenological Study

    ERIC Educational Resources Information Center

    Sangganjanavanich, Varunee Faii; Lenz, A. Stephen; Cavazos, Javier, Jr.

    2011-01-01

    After completing their academic degree, international student populations face unique situations in their search for employment in the United States. This study used a phenomenological examination to identify the perceptions and the experiences of eight undergraduate international students who participated in a 10-week support group during the…

  2. Dialogical Approach Applied in Group Counselling: Case Study

    ERIC Educational Resources Information Center

    Koivuluhta, Merja; Puhakka, Helena

    2013-01-01

    This study utilizes structured group counselling and a dialogical approach to develop a group counselling intervention for students beginning a computer science education. The study assesses the outcomes of group counselling from the standpoint of the development of the students' self-observation. The research indicates that group counselling…

  3. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report

    PubMed Central

    Bringhen, Sara; Mateos, Maria-Victoria; Larocca, Alessandra; Facon, Thierry; Kumar, Shaji K.; Offidani, Massimo; McCarthy, Philip; Evangelista, Andrea; Lonial, Sagar; Zweegman, Sonja; Musto, Pellegrino; Terpos, Evangelos; Belch, Andrew; Hajek, Roman; Ludwig, Heinz; Stewart, A. Keith; Moreau, Philippe; Anderson, Kenneth; Einsele, Hermann; Durie, Brian G. M.; Dimopoulos, Meletios A.; Landgren, Ola; San Miguel, Jesus F.; Richardson, Paul; Sonneveld, Pieter; Rajkumar, S. Vincent

    2015-01-01

    We conducted a pooled analysis of 869 individual newly diagnosed elderly patient data from 3 prospective trials. At diagnosis, a geriatric assessment had been performed. An additive scoring system (range 0-5), based on age, comorbidities, and cognitive and physical conditions, was developed to identify 3 groups: fit (score = 0, 39%), intermediate fitness (score = 1, 31%), and frail (score ≥2, 30%). The 3-year overall survival was 84% in fit, 76% in intermediate-fitness (hazard ratio [HR], 1.61; P = .042), and 57% in frail (HR, 3.57; P < .001) patients. The cumulative incidence of grade ≥3 nonhematologic adverse events at 12 months was 22.2% in fit, 26.4% in intermediate-fitness (HR, 1.23; P = .217), and 34.0% in frail (HR, 1.74; P < .001) patients. The cumulative incidence of treatment discontinuation at 12 months was 16.5% in fit, 20.8% in intermediate-fitness (HR, 1.41; P = .052), and 31.2% in frail (HR, 2.21; P < .001) patients. Our frailty score predicts mortality and the risk of toxicity in elderly myeloma patients. The International Myeloma Working group proposes this score for the measurement of frailty in designing future clinical trials. These trials are registered at www.clinicaltrials.gov as #NCT01093136 (EMN01), #NCT01190787 (26866138MMY2069), and #NCT01346787 (IST-CAR-506). PMID:25628469

  4. PREFACE: Seventh International Workshop: Group Analysis of Differential Equations and Integrable Systems (GADEISVII)

    NASA Astrophysics Data System (ADS)

    Vaneeva, Olena; Sophocleous, Christodoulos; Popovych, Roman; Boyko, Vyacheslav; Damianou, Pantelis

    2015-06-01

    The Seventh International Workshop "Group Analysis of Differential Equations and Integrable Systems" (GADEIS-VII) took place at Flamingo Beach Hotel, Larnaca, Cyprus during the period June 15-19, 2014. Fifty nine scientists from nineteen countries participated in the Workshop, and forty one lectures were presented. The Workshop topics ranged from theoretical developments of group analysis of differential equations, hypersymplectic structures, theory of Lie algebras, integrability and superintegrability to their applications in various fields. The Series of Workshops is a joint initiative by the Department of Mathematics and Statistics, University of Cyprus, and the Department of Applied Research of the Institute of Mathematics, National Academy of Sciences, Ukraine. The Workshops evolved from close collaboration among Cypriot and Ukrainian scientists. The first three meetings were held at the Athalassa campus of the University of Cyprus (October 27, 2005, September 25-28, 2006, and October 4-5, 2007). The fourth (October 26-30, 2008), the fifth (June 6-10, 2010) and the sixth (June 17-21, 2012) meetings were held at the coastal resort of Protaras. We would like to thank all the authors who have published papers in the Proceedings. All of the papers have been reviewed by at least two independent referees. We express our appreciation of the care taken by the referees. Their constructive suggestions have improved most of the papers. The importance of peer review in the maintenance of high standards of scientific research can never be overstated. Olena Vaneeva, Christodoulos Sophocleous, Roman Popovych, Vyacheslav Boyko, Pantelis Damianou

  5. An International Strategy for Human Exploration of the Moon: The International Space Exploration Coordination Group (ISECG) Reference Architecture for Human Lunar Exploration

    NASA Technical Reports Server (NTRS)

    Laurini, Kathleen C.; Hufenbach, Bernhard; Junichiro, Kawaguchi; Piedboeuf, Jean-Claude; Schade, Britta; Lorenzoni, Andrea; Curtis, Jeremy; Hae-Dong, Kim

    2010-01-01

    The International Space Exploration Coordination Group (ISECG) was established in response to The Global Exploration Strategy: The Framework for Coordination developed by fourteen space agencies and released in May 2007. Several ISECG participating space agencies have been studying concepts for human exploration of the moon that allow individual and collective goals and objectives to be met. This 18 month study activity culminated with the development of the ISECG Reference Architecture for Human Lunar Exploration. The reference architecture is a series of elements delivered over time in a flexible and evolvable campaign. This paper will describe the reference architecture and how it will inform near-term and long-term programmatic planning within interested agencies. The reference architecture is intended to serve as a global point of departure conceptual architecture that enables individual agency investments in technology development and demonstration, International Space Station research and technology demonstration, terrestrial analog studies, and robotic precursor missions to contribute towards the eventual implementation of a human lunar exploration scenario which reflects the concepts and priorities established to date. It also serves to create opportunities for partnerships that will support evolution of this concept and its eventual realization. The ISECG Reference Architecture for Human Lunar Exploration (commonly referred to as the lunar gPoD) reflects the agency commitments to finding an effective balance between conducting important scientific investigations of and from the moon, as well as demonstrating and mastering the technologies and capabilities to send humans farther into the Solar System. The lunar gPoD begins with a robust robotic precursor phase that demonstrates technologies and capabilities considered important for the success of the campaign. Robotic missions will inform the human missions and buy down risks. Human exploration will start

  6. A Study of Group Dynamics in Educational Leadership Cohort and Non-Cohort Groups

    ERIC Educational Resources Information Center

    Greenlee, Bobbie J.; Karanxha, Zorka

    2010-01-01

    The purpose of this study was to examine group dynamics of educational leadership students in cohorts and make comparisons with the group dynamics characteristics of non-cohort students. Cohorts have emerged as dynamic and adaptive entities with attendant group dynamic processes that shape collective learning and action. Cohort (n=42) and…

  7. Group Work Experiences: Domestic MBA Student Experiences and Outcomes when Working with International Students

    ERIC Educational Resources Information Center

    Rafferty, Patricia D.

    2013-01-01

    This article forms part of an exploration into the results of a single-case, embedded study that was conducted to explore how domestic part-time graduate business students in the United States experience group work for summative assessment. Multiple information collection methods were utilised, including open-ended and semi-structured interviews,…

  8. International Computer and Information Literacy Study: ICILS 2013 User Guide for the International Database

    ERIC Educational Resources Information Center

    Jung, Michael, Ed.; Carstens, Ralph, Ed.

    2015-01-01

    The International Computer and Information Literacy Study (ICILS) 2013, conducted by the International Association for the Evaluation of Educational Achievement (IEA), studied how students in different countries develop the knowledge, understanding, attitudes, dispositions, and skills that comprise computer and information literacy (CIL). The aim…

  9. [Radiological study of the internal carotid artery].

    PubMed

    Meder, J F; Brugières, P; Leguen, O

    1993-12-01

    Three radiologic methods are used to investigate the internal carotid artery. The main indication of CT scan is the assessment of brain ischaemic complications of carotid disease. Magnetic resonance imaging allows in addition to detect dissecting hematomas and carotid flow abnormalities. Cerebral angiography, which owes much to the advent of digital techniques, remains the standard examination of internal carotid artery. Complications of angiography although rare and usually benign explain the recent development of less invasive explorations such as dynamic CT scan and magnetic resonance angiography. This latter method is still under evaluation for diagnosis of carotid stenosis and small size aneurysms.

  10. Mongolism, Ciba Foundation Study Group Number 25.

    ERIC Educational Resources Information Center

    Wolstenholme, G. E. W., Ed.; Porter, Ruth, Ed.

    Resulting from a 1-day conference on mongolism, the book contains research studies and discussion summaries. Papers include "Parental Age, Live-Birth Order, and Pregnancy-Free Interval in Down's Syndrome in Japan" by E. Matsunaga, "Consanguineous Marriages and Mongolism" by H. Foressman and H. O. Akesson, "Correlation of Dermal Patterns on…

  11. The Social Sciences and the Study of International Relations.

    ERIC Educational Resources Information Center

    Braillard, Philippe

    1984-01-01

    International relations has become a subject of research for the various social sciences. An interdisciplinary approach is needed. Social scientists have been striving to adopt a scientific approach to the study of international phenomena, but there are limitations to finding an explanatory theory of international relations. (RM)

  12. International Students' Networks: A Case Study in a UK University

    ERIC Educational Resources Information Center

    Taha, Nashrawan; Cox, Andrew

    2016-01-01

    The great influx of international students into UK universities has led to internationalisation becoming an important issue. Previous studies have focused on the integration of home and international students, illustrating a lack of intercultural interaction. Yet there has been a lack of research investigating international students' networks and…

  13. Conformations and Barriers to Methyl Group Internal Rotation in Two Asymmetric Ethers: Propyl Methyl Ether and Butyl Methyl Ether

    NASA Astrophysics Data System (ADS)

    Long, B. E.; Dechirico, F.; Cooke, S. A.

    2012-06-01

    The conformational preferences of the O-C-C-C unit are important in many biological systems with the unit generally preferring a gauche configuration compared to an anti configuration. Butyl methyl ether and propyl methyl ether provide very simple systems for this phenomenom to manifest. Pure rotational spectra of the title molecules have been recorded using chirped pulse Fourier transform microwave spectroscopy (CP-FTMW). In the case of butyl methyl ether, only one conformer has been observed. This conformer has torsional angles of COCC = 180°, OCCC = 62° and CCCC = 180° (anti-gauche-anti) and rotational constants of A = 10259.4591(33) MHz, B = 1445.6470(13) MHz, and C = 1356.2944(14) MHz. The rotational spectrum was doubled and has been analyzed to produce an effective barrier to methyl group internal rotation of 780(35) cm-1. A prior rotational spectroscopic study on propyl methyl ether had focused only on the high energy anti-anti conformer. We have analyzed spectra from the lowest energy anti-gauche conformer and the spectroscopic constants will be presented. A summary of the differences in conformational energies and methyl group internal rotation barriers for the class of aliphatic asymmetric ethers will be presented. K. N. Houk, J. E. Eksterowicz, Y.-D. Wu, C. D. Fuglesang, D. B. Mitchell. J. Am. Chem. Soc. 115 (4170), 1993. Hiroshi Kato, Jun Nakagawa, Michiro Hayashi. J. Mol. Spectrosc. 80 (272), 1980.

  14. Capacitor Bank Series Group Shorting (CAPS) Design Study : Final Report.

    SciTech Connect

    Bruns, D.P.; Miske, S.A. Jr.; Newcomb, G.; Taylor, C.W.; Lee, G.

    1998-03-01

    The possibility of voltage collapse is a concern in many areas of the power system. Among the solutions to this problem are the addition of reactive compensation in the load area. Because the reactive power output of shunt capacitor banks is proportional to the voltage squared, shunt capacitor banks can increase power system vulnerability to voltage collapse. A new shunt capacitor bank control termed CAPS (CAPacitor bank series group Shorting) has been developed by Bonneville Power Administration (BPA) as cost-effective approach in improving power system stability during under-voltage emergencies. CAPS makes available, for finite periods of time, additional reactive power from a shunt bank by the use of a shorting switch to exploit the time-overvoltage capability of the capacitors. This report documents the results of a design study to optimize CAPS as applied to EHV and HV shunt capacitor banks. The study encompasses all aspects of capacitor bank design: capacitor units, capacitor bank arrangement, switch-gear, fusing (external, internal and fuseless), control and protection, risk assessment and economics. Various design options involving standard, readily available components are examined. The study also examines the feasibility of using electronic switching to enhance the CAPS concept. The study concludes that CAPS can be built from standard, commercially available components and has an economic advantage over conventional shunt capacitor banks with similar reactive power control.

  15. Challenges and opportunities in international molecular cancer prevention research: An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report.

    PubMed

    Epplein, Meira; Bostick, Roberd M; Mu, Lina; Ogino, Shuji; Braithwaite, Dejana; Kanetsky, Peter A

    2014-11-01

    The International Agency for Research on Cancer estimates that over half of the new cancer cases and almost two-thirds of the cancer deaths in 2012 occurred in low and middle income countries. To discuss the challenges and opportunities to reducing the burden of cancer worldwide, the Molecular Epidemiology and the Environment and the International Issues in Cancer Special Interest Groups joined forces to hold a session during the 38th Annual Meeting of the American Society of Preventive Oncology (March 2014, Arlington, Virginia). The session highlighted three topics of particular interest to molecular cancer prevention researchers working internationally, specifically: 1) biomarkers in cancer research; 2) environmental exposures and cancer; and 3) molecular pathological epidemiology. A major factor for successful collaboration illuminated during the discussion was the need for strong, committed, and reliable international partners. A key element of establishing such relationships is to thoroughly involve individual international collaborators in the development of the research question; engaged international collaborators are particularly motivated to champion and shepherd the project through all necessary steps, including issues relating to institutional review boards, political sensitivity, laboratory-based assays, and tumor subtyping. Also essential is allotting time for the building, maintaining, and investing in such relationships so that successful international collaborations may take root and bloom. While there are many challenges inherent to international molecular cancer research, the opportunities for furthering the science and prevention of cancer worldwide are great, particularly at this time of increasing cancer incidence and prevalence in low and middle income countries.

  16. A Study and Simulation of International Trade.

    ERIC Educational Resources Information Center

    Hilke, Eileen Veronica; Skrentny, Ray

    1990-01-01

    Illustrates a fifth grade teaching unit on international economics. Gives suggestions for use at the lower elementary and primary grades and points out that incorporation of economics into the elementary education curriculum can produce economically literate citizens in a cost-effective way. (GG)

  17. International Practice and Comparative Legal Studies.

    ERIC Educational Resources Information Center

    Cummins, Richard J.

    1985-01-01

    The lack of knowledge of and sensitivity to the basic features of foreign legal systems on the part of lawyers doing international work is related to a general lack of legal scholarship. The methodology and subject matter of comparative law must be renewed and revived at a time when barriers between legal systems seem to be increasing. (MSE)

  18. Study Abroad Ghana: An International Experiential Learning

    ERIC Educational Resources Information Center

    Boateng, Alice; Thompson, Abigail Mercy

    2013-01-01

    The global nature of social problems indicates how important it is for social workers to be involved in international issues. For example, overseas experience in social work programs is in consonance with the Council on Social Work Education's emphasis on global context of social work practice. In view of this, some schools of social work are…

  19. An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke.

    PubMed

    Smith, C J; Livingston, S D; Doolittle, D J

    1997-01-01

    The International Agency for Research on Cancer (IARC) currently lists 44 individual chemical agents, 12 groups or mixtures of chemicals and 13 exposure circumstances as "Group 1 human carcinogens". A comprehensive search of the published literature revealed that nine of the 44 chemical agents classified as "Group I carcinogens" by IARC have been reported to occur in mainstream cigarette smoke. The other 35 have never been reported to occur in cigarette smoke. The nine agents reported are benzene, cadmium, arsenic, nickel, chromium, 2-naphthyl-amine, vinyl chloride, 4-aminobiphenyl and beryllium. The reported yields of each of these nine agents in mainstream smoke varies widely. The range of yields reported for a given compound is influenced by the type of cigarette tested and when the analysis was conducted. In micrograms/cigarette, the ranges that have been reported for each of the nine compounds are: benzene (0.05-104), cadmium (0-6.67), arsenic (0-1.4), nickel (0-0.51), chromium (0.0002-0.5), 2-naphthylamine (0.0002-0.022), vinyl chloride (0.0013-0.0158), 4-aminobiphenyl (0.00019-0.005) and beryllium (0-0.0005). Although some of the variation in reported yields may be due to differences in analytical methodology, several correlations between the yield of a particular chemical in mainstream smoke and certain cigarette characteristics were observed. For example, charcoal filtration was associated with reduced vinyl chloride, and the concentration of sodium nitrate in the tobacco was positively correlated with the mainstream yield of both 2-naphthylamine and 4-aminobiphenyl. Benzene yield in mainstream cigarette smoke was correlated with the amount of tobacco burned and with the 'tar' level. Agronomic factors such as production practices and soil characteristics, and environmental conditions such as rainfall, reportedly influence the accumulation of metals, for example, cadmium, beryllium, chromium, nickel and arsenic, in the leaf. The use of fertilizers low in

  20. Environmental Studies Group progress report for 1979

    SciTech Connect

    Hunt, D.C.; Hurley, J.D.

    1981-01-21

    The 1979 progress report gives descriptions, results, and/or status on programs involving (1) physical transport of radionuclides in blowing dust, (2) radionuclide distributions in the sediment of area water bodies, (3) management of open space lands (including a remote sensing program) at Rocky Flats, (4) the ecology and radioecology of terrestrial open space areas in Plant site lands, (5) biological pathways for radionuclide transport, (6) evaluations of environmental monitoring data on radionuclides in air and water, (7) results of a special soil sampling program on lands adjacent to the Plant site, and (8) two special programs - one concerning evaluations of epidemiological studies of health effects purported to be related to the Plant, and a second that specifies information on accumulations of material in process building filter plenums required for evaluation of potential accidents.

  1. The Experiences of Expert Group Work Supervisors: An Exploratory Study

    ERIC Educational Resources Information Center

    Atieno Okech, Jane E.; Rubel, Deborah

    2009-01-01

    Evaluation of group work supervision literature suggests that description of expert group work supervisors' experiences could be useful for expanding existing group work supervision practices and models. This study provided a systematic exploration of the experiences of expert group work supervisors during the supervision process. Results indicate…

  2. Development and Dematerialization: An International Study

    PubMed Central

    Steinberger, Julia K.; Krausmann, Fridolin; Getzner, Michael; Schandl, Heinz; West, Jim

    2013-01-01

    Economic development and growth depend on growing levels of resource use, and result in environmental impacts from large scale resource extraction and emissions of waste. In this study, we examine the resource dependency of economic activities over the past several decades for a set of countries comprising developing, emerging and mature industrialized economies. Rather than a single universal industrial development pathway, we find a diversity of economic dependencies on material use, made evident through cluster analysis. We conduct tests for relative and absolute decoupling of the economy from material use, and compare these with similar tests for decoupling from carbon emissions, both for single countries and country groupings using panel analysis. We show that, over the longer term, emerging and developing countries tend to have significantly larger material-economic coupling than mature industrialized economies (although this effect may be enhanced by trade patterns), but that the contrary is true for short-term coupling. Moreover, we demonstrate that absolute dematerialization limits economic growth rates, while the successful industrialization of developing countries inevitably requires a strong material component. Alternative development priorities are thus urgently needed both for mature and emerging economies: reducing absolute consumption levels for the former, and avoiding the trap of resource-intensive economic and human development for the latter. PMID:24204555

  3. Development and dematerialization: an international study.

    PubMed

    Steinberger, Julia K; Krausmann, Fridolin; Getzner, Michael; Schandl, Heinz; West, Jim

    2013-01-01

    Economic development and growth depend on growing levels of resource use, and result in environmental impacts from large scale resource extraction and emissions of waste. In this study, we examine the resource dependency of economic activities over the past several decades for a set of countries comprising developing, emerging and mature industrialized economies. Rather than a single universal industrial development pathway, we find a diversity of economic dependencies on material use, made evident through cluster analysis. We conduct tests for relative and absolute decoupling of the economy from material use, and compare these with similar tests for decoupling from carbon emissions, both for single countries and country groupings using panel analysis. We show that, over the longer term, emerging and developing countries tend to have significantly larger material-economic coupling than mature industrialized economies (although this effect may be enhanced by trade patterns), but that the contrary is true for short-term coupling. Moreover, we demonstrate that absolute dematerialization limits economic growth rates, while the successful industrialization of developing countries inevitably requires a strong material component. Alternative development priorities are thus urgently needed both for mature and emerging economies: reducing absolute consumption levels for the former, and avoiding the trap of resource-intensive economic and human development for the latter. PMID:24204555

  4. Development and dematerialization: an international study.

    PubMed

    Steinberger, Julia K; Krausmann, Fridolin; Getzner, Michael; Schandl, Heinz; West, Jim

    2013-01-01

    Economic development and growth depend on growing levels of resource use, and result in environmental impacts from large scale resource extraction and emissions of waste. In this study, we examine the resource dependency of economic activities over the past several decades for a set of countries comprising developing, emerging and mature industrialized economies. Rather than a single universal industrial development pathway, we find a diversity of economic dependencies on material use, made evident through cluster analysis. We conduct tests for relative and absolute decoupling of the economy from material use, and compare these with similar tests for decoupling from carbon emissions, both for single countries and country groupings using panel analysis. We show that, over the longer term, emerging and developing countries tend to have significantly larger material-economic coupling than mature industrialized economies (although this effect may be enhanced by trade patterns), but that the contrary is true for short-term coupling. Moreover, we demonstrate that absolute dematerialization limits economic growth rates, while the successful industrialization of developing countries inevitably requires a strong material component. Alternative development priorities are thus urgently needed both for mature and emerging economies: reducing absolute consumption levels for the former, and avoiding the trap of resource-intensive economic and human development for the latter.

  5. Transformation of Air Quality Monitor Data from the International Space Station into Toxicological Effect Groups

    NASA Technical Reports Server (NTRS)

    James, John T.; Zalesak, Selina M.

    2011-01-01

    The primary reason for monitoring air quality aboard the International Space Station (ISS) is to determine whether air pollutants have collectively reached a concentration where the crew could experience adverse health effects. These effects could be near-real-time (e.g. headache, respiratory irritation) or occur late in the mission or even years later (e.g. cancer, liver toxicity). Secondary purposes for monitoring include discovery that a potentially harmful compound has leaked into the atmosphere or that air revitalization system performance has diminished. Typical ISS atmospheric trace pollutants consist of alcohols, aldehydes, aromatic compounds, halo-carbons, siloxanes, and silanols. Rarely, sulfur-containing compounds and alkanes are found at trace levels. Spacecraft Maximum Allowable Concentrations (SMACs) have been set in cooperation with a subcommittee of the National Research Council Committee on Toxicology. For each compound and time of exposure, the limiting adverse effect(s) has been identified. By factoring the analytical data from the Air Quality Monitor (AQM), which is in use as a prototype instrument aboard the ISS, through the array of compounds and SMACs, the risk of 16 specific adverse effects can be estimated. Within each adverse-effect group, we have used an additive model proportioned to each applicable 180-day SMAC to estimate risk. In the recent past this conversion has been performed using archival data, which can be delayed for months after an air sample is taken because it must be returned to earth for analysis. But with the AQM gathering in situ data each week, NASA is in a position to follow toxic-effect groups and correlate these with any reported crew symptoms. The AQM data are supplemented with data from real-time CO2 instruments aboard the ISS and from archival measurements of formaldehyde, which the AQM cannot detect.

  6. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma.

    PubMed

    Kumar, Shaji; Paiva, Bruno; Anderson, Kenneth C; Durie, Brian; Landgren, Ola; Moreau, Philippe; Munshi, Nikhil; Lonial, Sagar; Bladé, Joan; Mateos, Maria-Victoria; Dimopoulos, Meletios; Kastritis, Efstathios; Boccadoro, Mario; Orlowski, Robert; Goldschmidt, Hartmut; Spencer, Andrew; Hou, Jian; Chng, Wee Joo; Usmani, Saad Z; Zamagni, Elena; Shimizu, Kazuyuki; Jagannath, Sundar; Johnsen, Hans E; Terpos, Evangelos; Reiman, Anthony; Kyle, Robert A; Sonneveld, Pieter; Richardson, Paul G; McCarthy, Philip; Ludwig, Heinz; Chen, Wenming; Cavo, Michele; Harousseau, Jean-Luc; Lentzsch, Suzanne; Hillengass, Jens; Palumbo, Antonio; Orfao, Alberto; Rajkumar, S Vincent; San Miguel, Jesus; Avet-Loiseau, Herve

    2016-08-01

    Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments. PMID:27511158

  7. Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group.

    PubMed

    Laubach, J; Garderet, L; Mahindra, A; Gahrton, G; Caers, J; Sezer, O; Voorhees, P; Leleu, X; Johnsen, H E; Streetly, M; Jurczyszyn, A; Ludwig, H; Mellqvist, U-H; Chng, W-J; Pilarski, L; Einsele, H; Hou, J; Turesson, I; Zamagni, E; Chim, C S; Mazumder, A; Westin, J; Lu, J; Reiman, T; Kristinsson, S; Joshua, D; Roussel, M; O'Gorman, P; Terpos, E; McCarthy, P; Dimopoulos, M; Moreau, P; Orlowski, R Z; Miguel, J S; Anderson, K C; Palumbo, A; Kumar, S; Rajkumar, V; Durie, B; Richardson, P G

    2016-05-01

    The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM. PMID:26710887

  8. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma.

    PubMed

    Kumar, Shaji; Paiva, Bruno; Anderson, Kenneth C; Durie, Brian; Landgren, Ola; Moreau, Philippe; Munshi, Nikhil; Lonial, Sagar; Bladé, Joan; Mateos, Maria-Victoria; Dimopoulos, Meletios; Kastritis, Efstathios; Boccadoro, Mario; Orlowski, Robert; Goldschmidt, Hartmut; Spencer, Andrew; Hou, Jian; Chng, Wee Joo; Usmani, Saad Z; Zamagni, Elena; Shimizu, Kazuyuki; Jagannath, Sundar; Johnsen, Hans E; Terpos, Evangelos; Reiman, Anthony; Kyle, Robert A; Sonneveld, Pieter; Richardson, Paul G; McCarthy, Philip; Ludwig, Heinz; Chen, Wenming; Cavo, Michele; Harousseau, Jean-Luc; Lentzsch, Suzanne; Hillengass, Jens; Palumbo, Antonio; Orfao, Alberto; Rajkumar, S Vincent; San Miguel, Jesus; Avet-Loiseau, Herve

    2016-08-01

    Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments.

  9. Mental health services for children in public care and other vulnerable groups: implications for international collaboration.

    PubMed

    Vostanis, Panos

    2010-10-01

    Children in public care and other vulnerable young groups (homeless, adopted, refugees) are increasingly becoming the focus of policy and service planning. There is strong evidence that all these client populations have high rates of mental health problems which are closely associated with other needs. We also have good knowledge on the factors that predispose individuals to and maintain mental health problems, as well as on the reasons for their not easily accessing and engaging with services. There is less evidence on the effectiveness of interventions or service models, although some interesting patterns are beginning to emerge. These include the need for inter-agency commissioning, clear care pathways, designated provision, applied therapeutic interventions, training for carers and frontline practitioners, and multi modal programmes. This paper discusses these issues, as well as ways forward, both for systems with relatively well developed child mental health services and for low-income countries. Service quality can be greatly strengthened by international collaboration on policy, practice and research networks, training and research. PMID:20923903

  10. Core competencies for shared decision making training programs: insights from an international, interdisciplinary working group.

    PubMed

    Légaré, France; Moumjid-Ferdjaoui, Nora; Drolet, Renée; Stacey, Dawn; Härter, Martin; Bastian, Hilda; Beaulieu, Marie-Dominique; Borduas, Francine; Charles, Cathy; Coulter, Angela; Desroches, Sophie; Friedrich, Gwendolyn; Gafni, Amiram; Graham, Ian D; Labrecque, Michel; LeBlanc, Annie; Légaré, Jean; Politi, Mary; Sargeant, Joan; Thomson, Richard

    2013-01-01

    Shared decision making is now making inroads in health care professionals' continuing education curriculum, but there is no consensus on what core competencies are required by clinicians for effectively involving patients in health-related decisions. Ready-made programs for training clinicians in shared decision making are in high demand, but existing programs vary widely in their theoretical foundations, length, and content. An international, interdisciplinary group of 25 individuals met in 2012 to discuss theoretical approaches to making health-related decisions, compare notes on existing programs, take stock of stakeholders concerns, and deliberate on core competencies. This article summarizes the results of those discussions. Some participants believed that existing models already provide a sufficient conceptual basis for developing and implementing shared decision making competency-based training programs on a wide scale. Others argued that this would be premature as there is still no consensus on the definition of shared decision making or sufficient evidence to recommend specific competencies for implementing shared decision making. However, all participants agreed that there were 2 broad types of competencies that clinicians need for implementing shared decision making: relational competencies and risk communication competencies. Further multidisciplinary research could broaden and deepen our understanding of core competencies for shared decision making training.

  11. Case study for international remote machining

    NASA Astrophysics Data System (ADS)

    Lin, Grier C. I.; Kao, Yung-Chou

    1995-08-01

    Owing to the more enhanced networking, the designed data for manufacturing can be transmitted internationally. Therefore, the production of the potential product at one side of the world according to the design requirement at the other side of the world is possible and quicker than ever before. The shipment can be eliminated by producing the product at the potential market place. This paper demonstrates the development of a machining system showing the manufacture of a product based on this idea. Unix, Microsoft Windows, and NFS under the LAN and Internet environment are adopted for data communication and message passing in the devised international remote machining system. The personal computer is the server of the machining center. A C program is developed for the direct control of the machining center through DNC2 interface. The command of machining process is issued from Sun Sparc station to the personal computer through Internet. The devised system structure can also be extended to link with an automatic workpiece loading system, e.g., robot an AGV, to form an automatic machining cell for CIM. The requirements of achieving such an international remote machining cell that links machining center and robot are also discussed.

  12. Characteristics of Highly Talented International Business Professionals Defined: Qualitative Study among International Business Professionals

    ERIC Educational Resources Information Center

    van Heugten, Petra; Heijne-Penninga, Marjolein; Paans, Wolter; Wolfensberger, Marca

    2016-01-01

    Purpose: The purpose of this paper is to explore the characteristics of talent in relation to international business to facilitate selection and development of talent in human resources (HR) and human resource development (HRD). Design/methodology/approach: A mixed method design was used: focus groups with business professionals to identify the…

  13. Reinventing US Internal Migration Studies in the Age of International Migration

    PubMed Central

    Ellis, Mark

    2014-01-01

    I argue that researchers have sidelined attention to issues raised by US internal migration as they shifted focus to the questions posed by the post-1960s rise in US immigration. In this paper, I offer some reasons about why immigration has garnered more attention and why there needs to be greater consideration of US internal migration and its significant and myriad social, economic, political, and cultural impacts. I offer three ideas for motivating more research into US internal geographic mobility that would foreground its empirical and conceptual connections to international migration. First, there should be more work on linked migration systems investigating the connections between internal and international flows. Second, the questions asked about immigrant social, cultural, and economic impacts and adaptations in host societies should also be asked about internal migrants. Third, and more generally, migration researchers should jettison the assumption that the national scale is the pre-eminent delimiter of migration types and processes. Some groups can move easily across borders; others are constrained in their moves within countries. These subnational scales and constraints will become more visible if migration research decentres the national from its theory and empirics. PMID:24839406

  14. Reinventing US Internal Migration Studies in the Age of International Migration.

    PubMed

    Ellis, Mark

    2012-03-01

    I argue that researchers have sidelined attention to issues raised by US internal migration as they shifted focus to the questions posed by the post-1960s rise in US immigration. In this paper, I offer some reasons about why immigration has garnered more attention and why there needs to be greater consideration of US internal migration and its significant and myriad social, economic, political, and cultural impacts. I offer three ideas for motivating more research into US internal geographic mobility that would foreground its empirical and conceptual connections to international migration. First, there should be more work on linked migration systems investigating the connections between internal and international flows. Second, the questions asked about immigrant social, cultural, and economic impacts and adaptations in host societies should also be asked about internal migrants. Third, and more generally, migration researchers should jettison the assumption that the national scale is the pre-eminent delimiter of migration types and processes. Some groups can move easily across borders; others are constrained in their moves within countries. These subnational scales and constraints will become more visible if migration research decentres the national from its theory and empirics. PMID:24839406

  15. Study Abroad: The Reality of Building Dynamic Group Learning.

    ERIC Educational Resources Information Center

    Ransbury, Molly K.; Harris, Sandra A.

    1994-01-01

    The collaborative effort of a professor of human development with expertise in group process and a general education professor with expertise in Greek mythology and culture uses a case study format to apply theoretical models of group dynamics to the travel and learning experience of study abroad. Implications for course design and group process…

  16. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (29th, Melbourne, Australia, July 10-15, 2005). Volume 3

    ERIC Educational Resources Information Center

    Chick, Helen L., Ed.; Vincent, Jill L., Ed.

    2005-01-01

    The third volume of the 29th annual conference of the International Group for the Psychology of Mathematics Education contains full research report papers. Papers include: (1) Students' Use of ICT Tools: Choices and Reasons (Anne Berit Fuglestad); (2) Interaction of Modalities in Cabri: A Case Study (Fulvia Furinghetti, Francesca Morselli, and…

  17. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (21st, Lahti, Finland, July 14-19, 1997). Volume 4.

    ERIC Educational Resources Information Center

    Pehkonen, Erkki, Ed.

    The fourth volume of the proceedings of 21st annual meeting of the International Group for the Psychology of Mathematics Education contains the following papers: (1) "A Model for Discriminating amongst Student Teachers of Mathematics" (P. Perks); (2) "A Study of Teachers' Conceptions about Mathematics" (G.N. Philippou and C. Christou); (3) "Emily…

  18. Proceedings of the Annual Conference of the International Group for the Psychology of Mathematics Education (19th, Recife, Brazil, July 22-27, 1995), Volume 2.

    ERIC Educational Resources Information Center

    Meira, Luciano, Ed.; Carraher, David, Ed.

    This proceedings of the annual conference of the International Group for the Psychology of Mathematics Education (PME) includes the following research papers: "The Impact of Meaning on Students' Ability to Negate Statements" (T. Barnard); "A Study of the Secondary Teaching System about the Concept of Limit" (L. Espinosa & C. Azcarate);…

  19. Small Group Instruction: A Study in Remedial Mathematics

    ERIC Educational Resources Information Center

    Chang, Ping-Tung

    1977-01-01

    This study compared the impacts of small-group instruction and lecture demonstration teaching on achievement and attitudes toward mathematics. Results indicated that small-group instruction was superior to the lecture method in producing achievement in remedial mathematics. (SD)

  20. Study on internal to surface fingerprint correlation using optical coherence tomography and internal fingerprint extraction

    NASA Astrophysics Data System (ADS)

    Darlow, Luke Nicholas; Connan, James

    2015-11-01

    Surface fingerprint scanners are limited to a two-dimensional representation of the fingerprint topography, and thus, are vulnerable to fingerprint damage, distortion, and counterfeiting. Optical coherence tomography (OCT) scanners are able to image (in three dimensions) the internal structure of the fingertip skin. Techniques for obtaining the internal fingerprint from OCT scans have since been developed. This research presents an internal fingerprint extraction algorithm designed to extract high-quality internal fingerprints from touchless OCT fingertip scans. Furthermore, it serves as a correlation study between surface and internal fingerprints. Provided the scanned region contains sufficient fingerprint information, correlation to the surface topography is shown to be good (74% have true matches). The cross-correlation of internal fingerprints (96% have true matches) is substantial that internal fingerprints can constitute a fingerprint database. The internal fingerprints' performance was also compared to the performance of cropped surface counterparts, to eliminate bias owing to information level present, showing that the internal fingerprints' performance is superior 63.6% of the time.

  1. International Space Station Electrodynamic Tether Reboost Study

    NASA Technical Reports Server (NTRS)

    Johnson, L.; Herrmann, M.

    1998-01-01

    The International Space Station (ISS) will require periodic reboost due to atmospheric aerodynamic drag. This is nominally achieved through the use of thruster firings by the attached Progress M spacecraft. Many Progress flights to the ISS are required annually. Electrodynamic tethers provide an attractive alternative in that they can provide periodic reboost or continuous drag cancellation using no consumables, propellant, nor conventional propulsion elements. The system could also serve as an emergency backup reboost system used only in the event resupply and reboost are delayed for some reason.

  2. International photonics training: a case study

    NASA Astrophysics Data System (ADS)

    Sporea, Dan; Massa, Nicholas; Donnelly, Judith F.; Hanes, Fenna

    2007-06-01

    From 2004, the Center for Science Education and Training (CSET) participated to the European Union-funded educational network "Hands-on Science". The aim of the Romanian team was to transform teachers and students from end-users of educational aids to active designers and developers of instructional materials. Several science fields were identified, including photonics. The team at CSET is now focusing on: lasers and their applications, optical fiber communications, solar energy as a sustainable source, and the use of optical spectroscopy in physics and chemistry. CSET initiated an international collaboration with the New England Board of Higher Education (NEBHE) in Boston, Mass., when the Center enrolled an experienced Romanian high school science teacher in a twelve-week "Introduction to Photonics" laboratory-based professional development course. The course was developed by NEBHE through an Advanced Technological Education (ATE) program grant from National Science Foundation and is designed for high school and community college educators from both science and technology instructional areas. The paper reports the experience of this international participation which was made possible since the course is delivered via the Internet by Three Rivers Community College, Norwich, Conn. Its impact on photonics education in Romania and the USA is analyzed, as the participant teacher shares her experiences with teachers and faculty in the "Introduction to Photonics" course and with those enrolled into the Romanian "Hands-on-Science" program.

  3. 76 FR 67256 - Advisory Group to the Commissioner of Internal Revenue; Renewal of Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... include representation from the taxpaying public, the tax professional community, small and large businesses, international, wage and investment taxpayers and the applicant's knowledge of Circular 230....

  4. 78 FR 66425 - Advisory Group to the Commissioner of Internal Revenue; Renewal of Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... include representation from the taxpaying public, the tax professional community, small and large businesses, international, wage and investment taxpayers and the applicant's knowledge of Circular 230....

  5. The distinct effects of internalizing weight bias: An experimental study.

    PubMed

    Pearl, Rebecca L; Puhl, Rebecca M

    2016-06-01

    Both experiencing and internalizing weight bias are associated with negative mental and physical health outcomes, but internalization may be a more potent predictor of these outcomes. The current study aimed to differentiate between causal effects of experiencing versus internalizing weight bias on emotional responses and psychological well-being. Adults with overweight/obesity (N=260) completed an online experiment in which they were randomly assigned to focus on either the experience or internalization of weight bias, and completed measures of affect, self-esteem, and body dissatisfaction. Results indicated that the Internalization condition led to more negative affect, less positive affect, and lower self-esteem than the Experience condition. The Internalization condition also led to heightened body dissatisfaction among men, but not women. These findings suggest that weight bias internalization may be a stronger predictor of poor mental and physical health than experiences alone, and carry implications for developing weight bias interventions. PMID:26927688

  6. The distinct effects of internalizing weight bias: An experimental study.

    PubMed

    Pearl, Rebecca L; Puhl, Rebecca M

    2016-06-01

    Both experiencing and internalizing weight bias are associated with negative mental and physical health outcomes, but internalization may be a more potent predictor of these outcomes. The current study aimed to differentiate between causal effects of experiencing versus internalizing weight bias on emotional responses and psychological well-being. Adults with overweight/obesity (N=260) completed an online experiment in which they were randomly assigned to focus on either the experience or internalization of weight bias, and completed measures of affect, self-esteem, and body dissatisfaction. Results indicated that the Internalization condition led to more negative affect, less positive affect, and lower self-esteem than the Experience condition. The Internalization condition also led to heightened body dissatisfaction among men, but not women. These findings suggest that weight bias internalization may be a stronger predictor of poor mental and physical health than experiences alone, and carry implications for developing weight bias interventions.

  7. International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma–Related Bone Disease

    PubMed Central

    Terpos, Evangelos; Morgan, Gareth; Dimopoulos, Meletios A.; Drake, Matthew T.; Lentzsch, Suzanne; Raje, Noopur; Sezer, Orhan; García-Sanz, Ramón; Shimizu, Kazuyuki; Turesson, Ingemar; Reiman, Tony; Jurczyszyn, Artur; Merlini, Giampaolo; Spencer, Andrew; Leleu, Xavier; Cavo, Michele; Munshi, Nikhil; Rajkumar, S. Vincent; Durie, Brian G.M.; Roodman, G. David

    2013-01-01

    Purpose The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) –related bone disease. Methodology An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published data through August 2012. Expert consensus was used to propose additional recommendations in situations where there were insufficient published data. Levels of evidence and grades of recommendations were assigned and approved by panel members. Recommendations Bisphosphonates (BPs) should be considered in all patients with MM receiving first-line antimyeloma therapy, regardless of presence of osteolytic bone lesions on conventional radiography. However, it is unknown if BPs offer any advantage in patients with no bone disease assessed by magnetic resonance imaging or positron emission tomography/computed tomography. Intravenous (IV) zoledronic acid (ZOL) or pamidronate (PAM) is recommended for preventing skeletal-related events in patients with MM. ZOL is preferred over oral clodronate in newly diagnosed patients with MM because of its potential antimyeloma effects and survival benefits. BPs should be administered every 3 to 4 weeks IV during initial therapy. ZOL or PAM should be continued in patients with active disease and should be resumed after disease relapse, if discontinued in patients achieving complete or very good partial response. BPs are well tolerated, but preventive strategies must be instituted to avoid renal toxicity or osteonecrosis of the jaw. Kyphoplasty should be considered for symptomatic vertebral compression fractures. Low-dose radiation therapy can be used for palliation of uncontrolled pain, impending pathologic fracture, or spinal cord compression. Orthopedic consultation should be sought for long-bone fractures, spinal cord compression, and vertebral column instability. PMID:23690408

  8. Studying abroad: a multiple case study of nursing students' international experiences.

    PubMed

    Green, Barbara F; Johansson, Inez; Rosser, Megan; Tengnah, Cassam; Segrott, Jeremy

    2008-11-01

    This paper examines the experiences of nursing students undertaking an international placement during their pre-registration education. The study took place in two schools--one in the United Kingdom, and one in Sweden. The move of nursing education into higher education enabled students to participate in international exchange programmes. Previous research demonstrates that students participating in such programmes may gain enhanced cultural awareness and experience personal and professional growth. The study comprised a multiple case study, utilising semi-structured individual and group interviews and documentary analysis. Eighteen students from the UK and 14 from Sweden participated. Participants described an increase in confidence, self-reliance and professional knowledge and skills resulting from their international placement. There was an awareness of how healthcare roles differ between countries and a change in attitudes to others from different backgrounds and cultures. The differences between the two cases were marginal. Whilst there was support from both home and host universities this varied between the international placement providers. The international placements were beneficial; however, there is a need for change in the preparation, support and monitoring of students, greater engagement with the partner institutions, and more effective mentoring of staff. PMID:18692278

  9. Studying abroad: a multiple case study of nursing students' international experiences.

    PubMed

    Green, Barbara F; Johansson, Inez; Rosser, Megan; Tengnah, Cassam; Segrott, Jeremy

    2008-11-01

    This paper examines the experiences of nursing students undertaking an international placement during their pre-registration education. The study took place in two schools--one in the United Kingdom, and one in Sweden. The move of nursing education into higher education enabled students to participate in international exchange programmes. Previous research demonstrates that students participating in such programmes may gain enhanced cultural awareness and experience personal and professional growth. The study comprised a multiple case study, utilising semi-structured individual and group interviews and documentary analysis. Eighteen students from the UK and 14 from Sweden participated. Participants described an increase in confidence, self-reliance and professional knowledge and skills resulting from their international placement. There was an awareness of how healthcare roles differ between countries and a change in attitudes to others from different backgrounds and cultures. The differences between the two cases were marginal. Whilst there was support from both home and host universities this varied between the international placement providers. The international placements were beneficial; however, there is a need for change in the preparation, support and monitoring of students, greater engagement with the partner institutions, and more effective mentoring of staff.

  10. Report of the International Society of Hypertension Teaching Seminar organized by the International Society of Hypertension Africa Regional Advisory Group: Maputo, Mozambique, 2016.

    PubMed

    Onwubere, Basden; Coca, Antonio; Damasceno, Albertino; Kadiri, Solomon; Kruger, Ruan; Lemogoum, Daniel; M'Buyamba-Kabangu, Jene-Rene; Okpechi, Ikechi; Poulter, Neil; Rayner, Brian; Seedat, Yakoob K; Schutte, Aletta E; Touyz, Rhian M

    2016-10-01

    The International Society of Hypertension (ISH), in fulfilment of its mission of promoting hypertension control and prevention and also of advancing knowledge globally, organizes hypertension teaching seminars or 'summer schools' worldwide through the ISH Regional Advisory Groups. In Africa, seven of such seminars have been organized. This is a report of the eighth seminar held in Maputo, Mozambique, April, 2016. The seminar was attended by over 65 participants from 11 African countries. The Faculty consisted of 11 international hypertension experts. The eighth African hypertension seminar was a great success as confirmed by a pre- and post-test questionnaire. PMID:27467769

  11. International Civic and Citizenship Education Study: Assessment Framework

    ERIC Educational Resources Information Center

    Schulz, Wolfram; Fraillon, Julian; Ainley, John; Losito, Bruno; Kerr, David

    2008-01-01

    This document outlines the framework and assessment design for the International Civic and Citizenship Education Study (ICCS) sponsored by the International Association for the Evaluation of Educational Achievement (IEA). Over the past 50 years, IEA has conducted comparative research studies focusing on educational policies, practices, and…

  12. Teaching, Learning, and Working with International Students: A Case Study.

    ERIC Educational Resources Information Center

    Parker, D. Randall

    This case study of a program for Taiwanese students at Louisiana Tech University examined the challenges and rewards of working with international students. Data for the study come from the literature on international education, interviews with Taiwanese graduate students in the program, observations of classes, personal reflections of the…

  13. International Dimensions in the Social Studies. 38th Yearbook.

    ERIC Educational Resources Information Center

    Becker, James M.; Mehlinger, Howard D.

    This thirty-eighth yearbook provides a framework for the teaching of international education and relates recent concepts and ideas in the international studies field which are applicable to the teaching of social studies. A number of educators and social scientists contributed to a series of chapters comprised in four sections of the volume. Each…

  14. Independent Senior Women Who Travel Internationally: A Collective Case Study

    ERIC Educational Resources Information Center

    Jarrett, Barbara

    2010-01-01

    Nine independent women over age 55 who traveled internationally were investigated through a qualitative case study. The purpose of the study was to explore the women's attitudes, actions, and motivations during and after their international travel experiences. The adult, aging, experiential, and transformational theories of researchers such as…

  15. International Space Station (ISS) Anomalies Trending Study

    NASA Technical Reports Server (NTRS)

    Beil, Robert J.; Brady, Timothy K.; Foster, Delmar C.; Graber, Robert R.; Malin, Jane T.; Thornesbery, Carroll G.; Throop, David R.

    2015-01-01

    The NASA Engineering and Safety Center (NESC) set out to utilize data mining and trending techniques to review the anomaly history of the International Space Station (ISS) and provide tools for discipline experts not involved with the ISS Program to search anomaly data to aid in identification of areas that may warrant further investigation. Additionally, the assessment team aimed to develop an approach and skillset for integrating data sets, with the intent of providing an enriched data set for discipline experts to investigate that is easier to navigate, particularly in light of ISS aging and the plan to extend its life into the late 2020s. This report contains the outcome of the NESC Assessment.

  16. Modern Radiation Therapy for Extranodal Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group

    SciTech Connect

    Yahalom, Joachim; Illidge, Tim; Specht, Lena; Hoppe, Richard T.; Li, Ye-Xiong; Tsang, Richard; Wirth, Andrew

    2015-05-01

    Extranodal lymphomas (ENLs) comprise about a third of all non-Hodgkin lymphomas (NHL). Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation. The wide range of presentations of ENL, involving any organ in the body and the spectrum of histological sub-types, poses a challenge both for routine clinical care and for the conduct of prospective and retrospective studies. This has led to uncertainty and lack of consistency in RT approaches between centers and clinicians. Thus far there is a lack of guidelines for the use of RT in the management of ENL. This report presents an effort by the International Lymphoma Radiation Oncology Group (ILROG) to harmonize and standardize the principles of treatment of ENL, and to address the technical challenges of simulation, volume definition and treatment planning for the most frequently involved organs. Specifically, detailed recommendations for RT volumes are provided. We have applied the same modern principles of involved site radiation therapy as previously developed and published as guidelines for Hodgkin lymphoma and nodal NHL. We have adopted RT volume definitions based on the International Commission on Radiation Units and Measurements (ICRU), as has been widely adopted by the field of radiation oncology for solid tumors. Organ-specific recommendations take into account histological subtype, anatomy, the treatment intent, and other treatment modalities that may be have been used before RT.

  17. Factors associated with pharmacy student interest in international study.

    PubMed

    Owen, Chelsea; Breheny, Patrick; Ingram, Richard; Pfeifle, William; Cain, Jeff; Ryan, Melody

    2013-04-12

    OBJECTIVES. To examine the interest of pharmacy students in international study, the demographic factors and involvement characteristics associated with that interest, and the perceived advantages and barriers of engaging in international opportunities during pharmacy school. METHODS. A self-administered electronic survey instrument was distributed to first-, second-, and third-year pharmacy students at the University of Kentucky College of Pharmacy. RESULTS. There were 192 total respondents, for a response rate of 50.9%. Seventy-two percent reported interest in international study. Previous international study experience (p=0.001), previous international travel experience (p=0.002), year in pharmacy school (p=0.03), level of academic involvement (p<0.001), and level of diversity involvement (p<0.001) were associated with international study interest. Positive influences to international study included desire to travel and availability of scholarships. Perceived barriers included an inability to pay expenses and lack of foreign language knowledge. CONCLUSIONS. The needs and interests of pharmacy students should be considered in the development and expansion of internationalization programs in order to effectively optimize global partnerships and available international experiences. Colleges and schools of pharmacy should engage students early in the curriculum when interest in study-abroad opportunities is highest and seek to alleviate concerns about expenses as a primary influence on study-abroad decisions through provision of financial assistance. PMID:23610472

  18. Factors Associated With Pharmacy Student Interest in International Study

    PubMed Central

    Owen, Chelsea; Breheny, Patrick; Ingram, Richard; Pfeifle, William; Cain, Jeff

    2013-01-01

    Objectives. To examine the interest of pharmacy students in international study, the demographic factors and involvement characteristics associated with that interest, and the perceived advantages and barriers of engaging in international opportunities during pharmacy school. Methods. A self-administered electronic survey instrument was distributed to first-, second-, and third-year pharmacy students at the University of Kentucky College of Pharmacy. Results. There were 192 total respondents, for a response rate of 50.9%. Seventy-two percent reported interest in international study. Previous international study experience (p=0.001), previous international travel experience (p=0.002), year in pharmacy school (p=0.03), level of academic involvement (p<0.001), and level of diversity involvement (p<0.001) were associated with international study interest. Positive influences to international study included desire to travel and availability of scholarships. Perceived barriers included an inability to pay expenses and lack of foreign language knowledge. Conclusions. The needs and interests of pharmacy students should be considered in the development and expansion of internationalization programs in order to effectively optimize global partnerships and available international experiences. Colleges and schools of pharmacy should engage students early in the curriculum when interest in study-abroad opportunities is highest and seek to alleviate concerns about expenses as a primary influence on study-abroad decisions through provision of financial assistance. PMID:23610472

  19. Improving Group Processes in Transdisciplinary Case Studies for Sustainability Learning

    ERIC Educational Resources Information Center

    Hansmann, Ralf; Crott, Helmut W.; Mieg, Harald A.; Scholz, Roland W.

    2009-01-01

    Purpose: Deficient group processes such as conformity pressure can lead to inadequate group decisions with negative social, economic, or environmental consequences. The study aims to investigate how a group technique (called INFO) improves students' handling of conformity pressure and their collective judgments in the context of a…

  20. Academic and Personal Development through Group Work: An Exploratory Study

    ERIC Educational Resources Information Center

    Steen, Sam

    2011-01-01

    This exploratory study linked academic and personal development within a group counseling intervention. A pre-test post-test research design compared social skills, learning behaviors, and achievement with a convenience sample and control group of students from three elementary schools. For the treatment group, grade point average in Language Arts…

  1. Cognitive Behavioral Principles within Group Mentoring: A Randomized Pilot Study

    ERIC Educational Resources Information Center

    Jent, Jason F.; Niec, Larissa N.

    2009-01-01

    This study evaluated the effectiveness of a group mentoring program that included components of empirically supported mentoring and cognitive behavioral techniques for children served at a community mental health center. Eighty-six 8- to 12-year-old children were randomly assigned to either group mentoring or a wait-list control group. Group…

  2. Group Therapy for Eating Disorders: A Retrospective Case Study

    ERIC Educational Resources Information Center

    Wanlass, Janine; Moreno, J. Kelly; Thomson, Hannah M.

    2005-01-01

    An increasing amount of research supports group therapy as an effective treatment option for eating disorders (Moreno, 1994). In an attempt to further delineate therapeutic factors associated with productive group work, this study represents an exploratory, descriptive analysis of client and therapist perspectives on group process and outcome.…

  3. English Curriculum Redesign through an EFL Teacher Study Group

    ERIC Educational Resources Information Center

    Yeh, Hui-chin

    2013-01-01

    This study investigates how a teacher study group collectively examined problems in their current English curriculum and redesigned the curriculum into theme-based lessons for various grades. Comprised of seven elementary school teachers and a teacher educator, the teacher study group met bi-weekly for three hours for a total of eight meetings.…

  4. The International Team in NanosafeTy (TITNT): A Multidisciplinary group for an improvement of Nanorisk Assessment and Management

    NASA Astrophysics Data System (ADS)

    Emond, C.; Rolando, C.; Hirano, S.; Schuster, F.; Jolliet, O.; Maghni, K.; Meyer-Plath, A.; Hallé, S.; Vandelac, L.; Sentein, C.; Torkaski, C.

    2011-07-01

    Nanotechnology allows the ability to design many new materials and devices with multiple applications, such as in medicine, electronics, and energy production. However, nanotechnology also raises several concerns about the toxicity and environmental impact of nanomaterials. A report published by the Council of Canadian Academies points out the necessity to respond about many uncertainties associated with risk assessment for ensuring the safety of health and environment. Nanotoxicology (or Nanosafety) is a part of the toxicology science that aims to study adverse effects of nanomaterials or nanoparticles on living organisms. This field includes different aspects from workers prevention to the environment protection. Group of researchers have initiated an international powerful interactive milieu for researchers to work in concert for a global and integrated study of many aspects of nanotoxicology. The International Team in NanosafeTy (TITNT) is composed of research scientists from 5 different countries (Canada, USA, Japan, France and Germany) working together on 6 different specific thematics, and organized as 9 different technology platforms (www.titnt.com). TITNT aims to study different features of nanomaterials related to nanosafety, such as in vivo and in vitro studies, life cycle, occupational protections and monitoring, early biomarkers detection, characterization and nanotoxicokinetic/dynamic assessment during and after nanoparticles synthesis and the societal, public policy and environmental aspects. While the rapid growth of nanotechnology is opening up a floodgate of opportunities, the legislation related is lagging behind mainly because of a lack of knowledge in the biosafety of most nanomaterials. The main goal of TITNT is to improve knowledge in nanosafety science for the benefit of the discipline, for better public policies and for the public itself.

  5. Tenth international meeting on Trypanosoma evansi: report of the working group. Paris, 24 May 1989.

    PubMed

    Touratier, L

    1990-12-01

    Some epidemiological surveys have provided information on the incidence of Trypanosoma evansi infection among dromedaries in Mali, and among buffaloes in Java and Indonesia. The disease among camels has been reported again from Kazakhstan in the USSR, with the coexistence of T. evansi and Cephalopina titillator in animals which developed acute infection. The disease has been studied among horses in Venezuela and among buffaloes in Vietnam and Indonesia, and suspected among horses in Brazil. Diagnostic kits for rapid and reliable detection of T. evansi are being made available free of charge, upon request, by the institutes which have developed these new techniques, namely: detecting the parasite by agglutination-lysis; detecting antibody (by a modification of CATT); detecting antigen (by using monoclonal antibodies). Once these various diagnostic procedures developed by competent institutes have been evaluated and used widely, the next step will be to standardise the techniques and the antigens. Differential diagnosis of T. evansi and T. equiperdum is still difficult in the case of akinetoplastic strains. For improved evaluation of T. evansi isolates, a proposal has been made to form collections of complementary DNA (cDNA) with a view to exchanging these copies and the original strains. The advice of the International Commission on Zoological Nomenclature has been requested for definitive adoption of a binomial designation for the species T. evansi. With more extensive data on the pharmacology and pharmacokinetics of Cymelarsan and laboratory testing of a new trypanocide called "IMOL 881", research on trypanocides continues. PMID:2132713

  6. 75 FR 66795 - International Paper, Pineville Mill, Industrial Packaging Group, Pineville, LA; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... 3, 2010 (75 FR 54187). The initial investigation resulted in a negative determination based on the... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration International Paper, Pineville Mill, Industrial Packaging...

  7. The effect of student participation in international study.

    PubMed

    DeDee, Lynda S; Stewart, Stephanie

    2003-01-01

    Comparative Nursing in England and France is taught at the University of Wisconsin Oshkosh every winter interim, usually departing shortly after Christmas and returning the second week in January. A convenience sample of 38 nursing alumni who have completed the same 2-week international study tour during the past 5 years completed the International Education Survey (IES) developed at the University of Wisconsin-Eau Claire School of Nursing. The IES examines the impact of the international experience on the professional nurse role, international perspectives, personal development, and intellectual development.

  8. Status of the IAA study group on traffic management rules for space operations

    NASA Astrophysics Data System (ADS)

    Contant, Corinne; Lala, Petr; Schrogl, Kai-Uwe

    2007-10-01

    The investigation of space traffic and its management has only recently become a point of wider discussion. In particular, the series of workshops organized by the American Institute of Aeronautics and Astronautics (AIAA) and other international organizations on international cooperation highlighted the issue. It was discussed thoroughly at the workshops, which took place in 1999 and 2001, respectively. It was at the 2001 workshop, when the suggestion was made that an International Academy of Astronautics (IAA) Study on the subject of space traffic management should be prepared. This suggestion was taken up and a proposal was presented to the Board of Trustees of IAA, which, in late 2001, accepted this proposal. Following this, an interdisciplinary study group of around 20 persons was composed. One early milestone in the process of work was the conduct of an International Institute of Space Law (IISL)/European Center of Space Law (ECSL) Symposium alongside the 2002 session of the United Nations Committee on the Peaceful Uses of Outer Space (UNCOPUOS) Legal Subcommittee. This symposium consisted of presentations of members of the IAA study group. Also, close coordination with other study projects of IAA, in particular with the one on space debris, is sought. This paper presents the status of work of the study group, in particular, the approach and the scope of the study as well as its preliminary findings. The study group intends to finalize its work in early 2004, in order to be able to put the study before IAA and launch its review process before the 2004 International Astronautical Congress. Following this review, the study will be published and may be expected to make an impact in fora like the UNCOPUOS. The authors of this paper act as the coordinators/the rapporteur to this study. The paper will be presented in the IAA—as well as the IISL—session dealing with space traffic, by that bridging the two areas and seeking input from various sources.

  9. Impact of Training on Change in Practice for Education Assistants in a Group of International Private Schools in Hong Kong

    ERIC Educational Resources Information Center

    Rose, Richard; Forlin, Chris

    2010-01-01

    This paper reports research that evaluated the efficacy of training for education assistants and its impact upon changing practices in a group of private international schools in Hong Kong, China. Two cohorts of education assistants received training through an education institute. The focus was on supporting and fostering inclusive practices in…

  10. 76 FR 56490 - In the Matter of Amerex Group, Inc., AmeriChip International, Inc., Amish Naturals, Inc., Banker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION In the Matter of Amerex Group, Inc., AmeriChip International, Inc., Amish Naturals, Inc., Banker's Store Inc. (The), Champion Parts, Inc., and Gray Peaks, Inc., Order of Suspension of Trading September 9, 2011. It appears to the Securities...

  11. A Study on Signal Group Processing of AUTOSAR COM Module

    NASA Astrophysics Data System (ADS)

    Lee, Jeong-Hwan; Hwang, Hyun Yong; Han, Tae Man; Ahn, Yong Hak

    2013-06-01

    In vehicle, there are many ECU(Electronic Control Unit)s, and ECUs are connected to networks such as CAN, LIN, FlexRay, and so on. AUTOSAR COM(Communication) which is a software platform of AUTOSAR(AUTomotive Open System ARchitecture) in the international industry standards of automotive electronic software processes signals and signal groups for data communications between ECUs. Real-time and reliability are very important for data communications in the vehicle. Therefore, in this paper, we analyze functions of signals and signal groups used in COM, and represent that functions of signal group are more efficient than signals in real-time data synchronization and network resource usage between the sender and receiver.

  12. International Learning Adventures: A Phenomenological Exploration of International Backpacker Style Study Abroad

    ERIC Educational Resources Information Center

    Thatcher, Chad Alan

    2010-01-01

    Self-awareness, cultural competency, environmental consciousness, and economic empathy are often achieved through study abroad travel experiences. This phenomenological study was intended to shed light on the international backpacking study abroad experiences for college students, describing the phenomenon from the perspective of the participants…

  13. Speaking up in groups: a cross-level study of group voice climate and voice.

    PubMed

    Morrison, Elizabeth Wolfe; Wheeler-Smith, Sara L; Kamdar, Dishan

    2011-01-01

    Despite a growing body of research on employee voice—defined as the discretionary communication of ideas, suggestions, or opinions intended to improve organizational or unit functioning—the effects of shared or collective-level cognitions have received scant attention. There has also been relatively little research on voice within work groups. Our goal in this study was to address these important gaps by focusing on the effects of group-level beliefs about voice (i.e., group voice climate) on individual voice behavior within work groups. We conducted a cross-level investigation of voice behavior within 42 groups of engineers from a large chemical company. Consistent with our hypotheses, group voice climate was highly predictive of voice and explained variance beyond the effects of individual-level identification and satisfaction, and procedural justice climate. Also consistent with predictions, the effect of identification on voice was stronger in groups with favorable voice climates. These findings provide evidence that voice is shaped not just by individual attitudes and perceptions of the work context, as past research has shown, but also by group-level beliefs. The results also highlight the importance of broadening our conceptual models of voice to include shared cognitions and of conducting additional cross-level research on voice. PMID:20718517

  14. Speaking up in groups: a cross-level study of group voice climate and voice.

    PubMed

    Morrison, Elizabeth Wolfe; Wheeler-Smith, Sara L; Kamdar, Dishan

    2011-01-01

    Despite a growing body of research on employee voice—defined as the discretionary communication of ideas, suggestions, or opinions intended to improve organizational or unit functioning—the effects of shared or collective-level cognitions have received scant attention. There has also been relatively little research on voice within work groups. Our goal in this study was to address these important gaps by focusing on the effects of group-level beliefs about voice (i.e., group voice climate) on individual voice behavior within work groups. We conducted a cross-level investigation of voice behavior within 42 groups of engineers from a large chemical company. Consistent with our hypotheses, group voice climate was highly predictive of voice and explained variance beyond the effects of individual-level identification and satisfaction, and procedural justice climate. Also consistent with predictions, the effect of identification on voice was stronger in groups with favorable voice climates. These findings provide evidence that voice is shaped not just by individual attitudes and perceptions of the work context, as past research has shown, but also by group-level beliefs. The results also highlight the importance of broadening our conceptual models of voice to include shared cognitions and of conducting additional cross-level research on voice.

  15. Motivating the Study of International Trade: A Classroom Activity

    ERIC Educational Resources Information Center

    Jensen, Sherry

    2016-01-01

    In this article, the author describes a classroom activity for use in introductory economics courses to motivate the study of international trade. The learning activity highlights the importance of international trade in students' everyday lives by having students inventory their on-hand belongings and identify where the items were manufactured.…

  16. A Program for High School Social Studies: International Relations.

    ERIC Educational Resources Information Center

    Bloomington Public Schools, MN.

    GRADES OR AGES: High school. SUBJECT MATTER: Social studies, International relations. ORGANIZATION AND PHYSICAL APPEARANCE: The introductory material covers the school district philosophy, a description of the program, major concepts for international relations, and techniques for evaluating objectives. Material is provided for six units…

  17. Using Case Studies: An International Approach

    ERIC Educational Resources Information Center

    McClam, Tricia; Woodside, Marianne

    2005-01-01

    Case studies as an instructional strategy have been used in many disciplines, including law, teacher education, science, medicine, and business. Among the benefits of this method of instruction are involving students in learning, developing their critical thinking skills, promoting communication, and engaging in critical analysis. Case studies are…

  18. Collaboration in Distance Education. International Case Studies.

    ERIC Educational Resources Information Center

    Moran, Louise, Ed.; Mugridge, Ian, Ed.

    This book contains nine case studies of collaboration in distance education. The case studies focus on such aspects of collaboration in distance education as the following: roles of individual institutional partners; importance of personal relationships; benefits of collaboration to individual partners; conflicts between collaboration and…

  19. Follow Up Study of Group Counseling with Underachieving College Freshmen.

    ERIC Educational Resources Information Center

    Valine, Warren J.

    The purpose of this study was to report long-range effects of group counseling and the college growth experience of students who were identified as underachievers and were enrolled as freshmen during the fall of 1969. Five variables were selected for this study as having possible influence on self-concept: (1) group, (2) education, (3) status, (4)…

  20. Cooperative Study Groups: Give Your Students the Home Team Advantage

    ERIC Educational Resources Information Center

    Lerma, Tony

    2007-01-01

    In this article I discuss the factors that led me to implement study groups in the teaching of mathematics. An important influence in this decision began with an experimental study conducted with two College Algebra classes in which students were randomly assigned to treatment groups. While there was no statistical difference between the study…

  1. Women's groups and individual entrepreneurs: a Ugandan case study.

    PubMed

    Pickering, H; Kajura, E; Katongole, G; Whitworth, J

    1996-10-01

    This study is based on interviews conducted among 8 women's income-generating groups and 12 individual women entrepreneurs in 15 villages in Masaka district, Uganda. The Baganda are the main tribe in the study villages. The study evaluates the economic achievement, objectives, and social characteristics of the groups. Groups ranged in size from 9-20 members. All had functioned for 3-5 years. A regular membership fee was paid through the sale of agricultural produce. Groups met at least every 2 weeks. This study revealed that the individual goals were to increase individual wealth, while the stated group goals were to invest in the community. Members considered the groups as useful in providing an easy way to raise capital. Most members considered financial status as a criterion for group membership. Elderly women tended to join social and handicraft groups. The women's group members tended to be friends before the establishment of the group and tended to be currently married to men residing in the area. Of the 12 women entrepreneurs, only 5 were currently married. All 12 women entrepreneurs had considerable initiative. The 12 women and the women's group members derived income from two or more sources: agricultural projects, animal husbandry, craft production, alcohol production and sale, or other activities. Study findings indicate that decisions were often delayed or avoided in order to preserve social cohesion. In a market-oriented enterprise, quick response time is needed and the bureaucratic dynamics would hinder some agricultural ventures. The poorest women experienced barriers to group membership. Women entrepreneurs were more successful than group women. PMID:12347716

  2. Women's groups and individual entrepreneurs: a Ugandan case study.

    PubMed

    Pickering, H; Kajura, E; Katongole, G; Whitworth, J

    1996-10-01

    This study is based on interviews conducted among 8 women's income-generating groups and 12 individual women entrepreneurs in 15 villages in Masaka district, Uganda. The Baganda are the main tribe in the study villages. The study evaluates the economic achievement, objectives, and social characteristics of the groups. Groups ranged in size from 9-20 members. All had functioned for 3-5 years. A regular membership fee was paid through the sale of agricultural produce. Groups met at least every 2 weeks. This study revealed that the individual goals were to increase individual wealth, while the stated group goals were to invest in the community. Members considered the groups as useful in providing an easy way to raise capital. Most members considered financial status as a criterion for group membership. Elderly women tended to join social and handicraft groups. The women's group members tended to be friends before the establishment of the group and tended to be currently married to men residing in the area. Of the 12 women entrepreneurs, only 5 were currently married. All 12 women entrepreneurs had considerable initiative. The 12 women and the women's group members derived income from two or more sources: agricultural projects, animal husbandry, craft production, alcohol production and sale, or other activities. Study findings indicate that decisions were often delayed or avoided in order to preserve social cohesion. In a market-oriented enterprise, quick response time is needed and the bureaucratic dynamics would hinder some agricultural ventures. The poorest women experienced barriers to group membership. Women entrepreneurs were more successful than group women.

  3. Building International Sustainable Partnerships in Occupational Therapy: A Case Study.

    PubMed

    Tupe, Debra Ann; Kern, Stephen B; Salvant, Sabrina; Talero, Pamela

    2015-09-01

    Occupational therapy practitioners frequently identify opportunities for international practice. The World Health Organization and the World Federation of Occupational Therapists have encouraged occupational therapists to address transnational issues, social inclusion, and equal access to opportunities grounded in meaningful occupation (WFOT, 2012). This case study describes a partnership between two U.S. schools of occupational therapy and a Cuban community based pediatric clinic. It examines the dynamics that have sustained the partnership despite political, economic, and logistical barriers. The literature is scrutinized to show how this case study fits into other accounts of collaborative international partnerships. Particularly, it investigates structural and institutional conditions that shape international sustainable partnerships. In doing so, we answer the following questions: (1) Under which circumstances do international partnerships emerge and flourish? (2) What structural and institutional conditions shape international sustainable partnerships? And (3) How do partners perceive and experience the bilateral international partnership? It also discusses and illustrates the foundations and development of international partnerships that succeed. Through the use of a case study we illustrate the development of this partnership. Finally, we consider the next steps of this particular sustainable and collaborative international partnership.

  4. Making Sense of Collaborative Learning in a Mentor Teacher Study Group: Examining the Joint Construction and Collective Warranting of Ideas.

    ERIC Educational Resources Information Center

    Carroll, David M.

    This study examined how an urban, elementary teacher study group helped five classroom teachers learn the practice of mentoring teacher candidates. A university liaison for one elementary school hosting interns led the group and conducted a longitudinal study of it as a context for collaborative learning. Teachers focused on making their teaching…

  5. Modern Radiation Therapy for Primary Cutaneous Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group

    SciTech Connect

    Specht, Lena; Dabaja, Bouthaina; Illidge, Tim; Wilson, Lynn D.; Hoppe, Richard T.

    2015-05-01

    Primary cutaneous lymphomas are a heterogeneous group of diseases. They often remain localized, and they generally have a more indolent course and a better prognosis than lymphomas in other locations. They are highly radiosensitive, and radiation therapy is an important part of the treatment, either as the sole treatment or as part of a multimodality approach. Radiation therapy of primary cutaneous lymphomas requires the use of special techniques that form the focus of these guidelines. The International Lymphoma Radiation Oncology Group has developed these guidelines after multinational meetings and analysis of available evidence. The guidelines represent an agreed consensus view of the International Lymphoma Radiation Oncology Group steering committee on the use of radiation therapy in primary cutaneous lymphomas in the modern era.

  6. Use of electronic group method in assessing food safety training needs and delivery methods among international college students in the U.S.

    PubMed

    Garden-Robinson, Julie; Eighmy, Myron A; Lyonga, Agnes Ngale

    2010-12-01

    The purpose of this study was to determine the types of unfamiliar foods international students in the U.S. encounter and to assess food safety information that international students would like to receive for mitigating risks associated with handling and preparing unfamiliar foods. The study identified preferred instructional delivery methods and media for receiving food safety training or information. An electronic group method was used for this study. The electronic group method was chosen to maximize group efficiency by allowing participants to share ideas simultaneously and anonymously with minimal use of time and resources.Types of different (unfamiliar) foods were grouped into major categories. Fast and ready-to-eat foods, and processed and frozen foods constituted a major change for some international students, who were accustomed to homemade and fresh foods in their countries. Participants were interested in receiving information about how to safely handle and prepare unfamiliar foods in their new environment. Preferred methods for receiving food safety information included written materials, online publications, presentations, and materials provided during student orientation. Food packages, websites, and television programs were other preferred methods of receiving food safety information.

  7. Research studies with the International Ultraviolet Explorer

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The IUE research studies comprises 118 separate research programs involving observations, data analysis, and research conducted of the IUE satellite and the NASA Astrophysics Data Program. Herein are presented 92 programs. For each program there is a title, program ID, name of the investigator, statement of work, summary of results, and list of publications.

  8. The Views of International Students Regarding University Support Services in Australia: A Case Study

    ERIC Educational Resources Information Center

    Roberts, Pam; Boldy, Duncan; Dunworth, Katie

    2015-01-01

    This paper reports on a study aimed at developing an improved understanding of the support needs of international students. Using a case study approach at one Australian university, a three stage data collection process was adopted: interviews with key support service providers in the university, student focus groups, and a large-scale survey.…

  9. Study of blood groups and rhesus isoimmunization in antenatal cases.

    PubMed

    Bhatnagar, D P; Bhutani, B

    1980-06-01

    The present study has been conducted on 1500 pregnant women of Patiala. All the cases were examined for ABO and Rh(D) blood groups; the Rh(D)-negative cases also for evidence of Rh-immunization. The distribution of ABO blood groups reveals 40.20% blood group B, 29.27% blood group O, 22.80% blood group A, and 7.73% blood group AB. Rh(D) blood types reveal 94.40% positive cases and 5.60% negative cases. Incidence of immunization was found to be 1.33% in the total sample and 23.80% in Rh(D)-negative cases. Comparison of these frequencies has been sought with some other studies.

  10. Geriatric assessment in multiple myeloma patients: validation of the International Myeloma Working Group (IMWG) score and comparison with other common comorbidity scores.

    PubMed

    Engelhardt, Monika; Dold, Sandra Maria; Ihorst, Gabriele; Zober, Alexander; Möller, Mandy; Reinhardt, Heike; Hieke, Stefanie; Schumacher, Martin; Wäsch, Ralph

    2016-09-01

    This first validation of the International Myeloma Working Group geriatric assessment in 125 newly diagnosed multiple myeloma patients was performed using the International Myeloma Working Group score based on age, the Charlson Comorbidity Index and cognitive and physical conditions (Activities of Daily Living / Instrumental Activities of Daily Living) to classify patients as fit, intermediate-fit or frail. We verified the International Myeloma Working Group score's impact on outcome, and whether additional tools complement it. Since our prior analyses determined renal, lung and Karnofsky performance impairment as multivariate risks, and the inclusion of frailty, age and cytogenetics complements this, we included the revised myeloma comorbidity index, the Charlson Comorbidity Index, the Hematopoietic Cell Transplantation-Comorbidity Index and the Kaplan-Feinstein Index in this assessment. Multivariate analysis confirmed cytogenetics, Activities of Daily Living, Instrumental Activities of Daily Living and the Charlson Comorbidity Index as risks: 3-year overall survival for fit, intermediate-fit and frail patients was 91%, 77% and 47%, respectively. Using the Charlson Comorbidity Index, the Hematopoietic Cell Transplantation-Comorbidity Index, the Kaplan-Feinstein Index and the revised Myeloma Comorbidity Index allowed us to define fit and frail patients with distinct progression-free and overall survival rates, with the most pronounced differences evidenced via the International Myeloma Working Group score, the Charlson Comorbidity Index and the revised Myeloma Comorbidity Index. Since the Charlson Comorbidity Index is included in the International Myeloma Working Group score, we propose the latter and the revised Myeloma Comorbidity Index for future frailty measurements. Both are useful instruments for identifying myeloma patients with a geriatric risk profile and have a strong prognostic value for functional decline and overall survival. The study was registered

  11. Geriatric assessment in multiple myeloma patients: validation of the International Myeloma Working Group (IMWG) score and comparison with other common comorbidity scores

    PubMed Central

    Engelhardt, Monika; Dold, Sandra Maria; Ihorst, Gabriele; Zober, Alexander; Möller, Mandy; Reinhardt, Heike; Hieke, Stefanie; Schumacher, Martin; Wäsch, Ralph

    2016-01-01

    This first validation of the International Myeloma Working Group geriatric assessment in 125 newly diagnosed multiple myeloma patients was performed using the International Myeloma Working Group score based on age, the Charlson Comorbidity Index and cognitive and physical conditions (Activities of Daily Living / Instrumental Activities of Daily Living) to classify patients as fit, intermediate-fit or frail. We verified the International Myeloma Working Group score’s impact on outcome, and whether additional tools complement it. Since our prior analyses determined renal, lung and Karnofsky performance impairment as multivariate risks, and the inclusion of frailty, age and cytogenetics complements this, we included the revised myeloma comorbidity index, the Charlson Comorbidity Index, the Hematopoietic Cell Transplantation-Comorbidity Index and the Kaplan-Feinstein Index in this assessment. Multivariate analysis confirmed cytogenetics, Activities of Daily Living, Instrumental Activities of Daily Living and the Charlson Comorbidity Index as risks: 3-year overall survival for fit, intermediate-fit and frail patients was 91%, 77% and 47%, respectively. Using the Charlson Comorbidity Index, the Hematopoietic Cell Transplantation-Comorbidity Index, the Kaplan-Feinstein Index and the revised Myeloma Comorbidity Index allowed us to define fit and frail patients with distinct progression-free and overall survival rates, with the most pronounced differences evidenced via the International Myeloma Working Group score, the Charlson Comorbidity Index and the revised Myeloma Comorbidity Index. Since the Charlson Comorbidity Index is included in the International Myeloma Working Group score, we propose the latter and the revised Myeloma Comorbidity Index for future frailty measurements. Both are useful instruments for identifying myeloma patients with a geriatric risk profile and have a strong prognostic value for functional decline and overall survival. The study was registered

  12. TEM Study of Internal Crystals in Supernova Graphites

    NASA Astrophysics Data System (ADS)

    Croat, T. K.; Bernatowicz, T.; Stadermann, F. J.; Messenger, S.; Amari, S.

    2003-03-01

    A coordinated TEM and isotopic study of ten supernova (SN) graphites from the Murchison meteorite has revealed many internal grains, mostly titanium carbides (TiCs) and TiC-kamacite composite grains, which were accreted during the graphite growth.

  13. 78 FR 29199 - Avani International Group, Inc., Birch Mountain Resources Ltd., Capital Reserve Canada Ltd...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... information concerning the securities of Laureate Resources & Steel Industries, Inc. because it has not filed...., Dynasty Gaming, Inc. (n/k/a Blue Zen Memorial Parks, Inc.), IXI Mobile, Inc., Laureate Resources & Steel Industries Inc., Millennium Energy Corp., Shannon International, Inc., and Welwind Energy...

  14. Culturally Mixed Groups on International Campuses: An Opportunity for Inter-Cultural Learning

    ERIC Educational Resources Information Center

    Volet, S. E.; Ang, G.

    2012-01-01

    One of the major educational goals of the internationalisation of higher education is to prepare students to function in an international and inter-cultural context. Cultural diversity on university campuses creates ideal social forums for inter-cultural learning, yet, one of the most disturbing aspects of the internationalisation of higher…

  15. Female Genital Mutilation: Proposals for Change. Minority Rights Group International Report. [Revised].

    ERIC Educational Resources Information Center

    Dorkenoo, Efua; Elworthy, Scilla

    In Africa today, women's voices are being raised against female genital mutilation. Inspired by the United Nations Decade for Women, this report seeks to present information in a logical, coherent manner to stimulate support for eradication of the practice. It describes steps African governments, Western states, and international agencies can take…

  16. Clinical and Biologic Features Predictive of Survival After Relapse of Neuroblastoma: A Report From the International Neuroblastoma Risk Group Project

    PubMed Central

    London, Wendy B.; Castel, Victoria; Monclair, Tom; Ambros, Peter F.; Pearson, Andrew D.J.; Cohn, Susan L.; Berthold, Frank; Nakagawara, Akira; Ladenstein, Ruth L.; Iehara, Tomoko; Matthay, Katherine K.

    2011-01-01

    Purpose Survival after neuroblastoma relapse is poor. Understanding the relationship between clinical and biologic features and outcome after relapse may help in selection of optimal therapy. Our aim was to determine which factors were significantly predictive of postrelapse overall survival (OS) in patients with recurrent neuroblastoma—particularly whether time from diagnosis to first relapse (TTFR) was a significant predictor of OS. Patients and Methods Patients with first relapse/progression were identified in the International Neuroblastoma Risk Group (INRG) database. Time from study enrollment until first event and OS time starting from first event were calculated. Cox regression models were used to calculate the hazard ratio of increased death risk and perform survival tree regression. TTFR was tested in a multivariable Cox model with other factors. Results In the INRG database (N = 8,800), 2,266 patients experienced first progression/relapse. Median time to relapse was 13.2 months (range, 1 day to 11.4 years). Five-year OS from time of first event was 20% (SE, ± 1%). TTFR was statistically significantly associated with OS time in a nonlinear relationship; patients with TTFR of 36 months or longer had the lowest risk of death, followed by patients who relapsed in the period of 0 to less than 6 months or 18 to 36 months. Patients who relapsed between 6 and 18 months after diagnosis had the highest risk of death. TTFR, age, International Neuroblastoma Staging System stage, and MYCN copy number status were independently predictive of postrelapse OS in multivariable analysis. Conclusion Age, stage, MYCN status, and TTFR are significant prognostic factors for postrelapse survival and may help in the design of clinical trials evaluating novel agents. PMID:21768459

  17. Grassroots Growth: The Evolution of a Teacher Study Group

    ERIC Educational Resources Information Center

    Maloney, Dana; Moore, Terry; Taylor, Monica

    2011-01-01

    Four years ago, a group of teachers lingered after a district meeting, sharing a conversation about encouraging social responsibility in the school district of Tenafly, New Jersey. That conversation led to the eventual formation of a teacher study group, a grassroots professional learning community that has impacted its members and the school…

  18. Educator Study Groups: A Professional Development Tool to Enhance Inclusion

    ERIC Educational Resources Information Center

    Herner-Patnode, Leah

    2009-01-01

    Professional development can take many forms. The most effective development includes individual educators in the formation and planning process. Educator study groups are one form of professional development that allows major stakeholders in the education process the autonomy to develop individual and group goals. This often translates into an…

  19. Group Time in Early Childhood Centers: An Exploratory Study.

    ERIC Educational Resources Information Center

    McAfee, Oralie

    To investigate the current status of group time in early childhood centers, a small-scale exploratory study was designed and executed. Results of interviews with 35 teachers and observations in five classrooms serving children ages 2 1/2 through kindergarten revealed that all classrooms had at least one group time or circle time, usually in the…

  20. Guide to International Studies at Canadian Universities = Guide pour les etudes internationales aux universites Canadiennes.

    ERIC Educational Resources Information Center

    Johnston, Pari, Ed.

    Included in this guide is a list of 65 Canadian universities and colleges offering programs in international and Native studies. Programs encompass area studies, international development, international relations, international business, international law, international agriculture, and international and comparative education. Also included are…

  1. Religious and national group identification in adolescence: a study among three religious groups in Mauritius.

    PubMed

    Ng Tseung-Wong, Caroline; Verkuyten, Maykel

    2013-01-01

    Religious group identification is an important but understudied social identity. The present study investigates religious group identification among adolescents of different faiths (Hindu, Muslim, Christian) living in multicultural Mauritius. It further explores how religious and national group identities come together among religious majority and minority adolescents. For three age groups (11 to 19 years, N = 2152) we examined the strength of adolescents' religious and national group identification, the associations between these two identities, and the relationships to global self-esteem. Across age and religious group, participants reported stronger identification with their religious group than with the nation. Identification with both categories declined with age, with the exception of Muslims, whose strong religious identification was found across adolescence. The association between religious and national identification was positive, albeit stronger for the majority group of Hindus and for early adolescents. We examined the manner in which religious and national identities come together using a direct self-identification measure and by combining the separate continuous measures of identification. Four distinct clusters of identification (predominant religious identifiers, dual identifiers, neutrals, and separate individuals) that were differently associated with global self-esteem were found. Dual identifiers reported the highest level of global self-esteem. The clusters of identification did not fully correspond to the findings for the direct self-identification measure. The results are discussed in terms of the meaning of dual identity and the positive manner in which adolescents can manage their multiple identities while taking into account the ideological framework in which those identities are played out. PMID:22822906

  2. The EVEREST study: an international collaboration*

    PubMed Central

    Caskey, Fergus J.; Stel, Vianda S.; Elliott, Robert F.; Jager, Kitty J.; Covic, Adrian; Cusumano, Ana; Geue, Claudia; Kramer, Anneke; Stengel, Benedicte; MacLeod, Alison M.

    2010-01-01

    Rates of initiation of renal replacement therapy (RRT), use of home modalities of treatment and patient outcomes vary considerably between countries. This paper reports the methods and baseline characteristics of countries participating in the EVEREST study (n = 46), a global collaboration examining the association between medical and non-medical factors and RRT incidence, modality mix and survival. Numbers of incident and prevalent patients were collected for current (2003–05) and historic (1983–85, 1988–90, 1993–95 and 1998–2000) periods stratified, where available, by age, gender, treatment modality and cause of end stage renal disease (diabetic versus non-diabetic). General population age and health indicators and national-level macroeconomic data were collected from secondary data sources. National experts provided primary data on renal service funding, resources and organization. The median (inter quartile range) RRT incidence per million of the population (pmp) was 130 pmp (102–167 pmp). The general population life expectancy at 60 was 22.1 years (19.7–23.1 years) and 6.9% had diabetes mellitus (5.4–9.0%). Healthcare spending as a percentage of gross domestic product was 8.1% (5.6–9.3%). Countries averaged nine dialysis facilities pmp (4–12 pmp), with 69.0% (43.9–99.0%) owned by the public or private not-for-profit sector. The number of nephrologists ranged from 0.5 to 48 pmp (median 12 pmp). The heterogeneity of EVEREST countries will enable modelling to examine the independent association between medical and non-medical factors on RRT epidemiology. PMID:25949402

  3. Ensuring global standards for medical graduates: a pilot study of international standard-setting.

    PubMed

    Stern, David T; Ben-David, Miriam Friedman; De Champlain, Andre; Hodges, Brian; Wojtczak, Andrzej; Schwarz, M Roy

    2005-05-01

    Increasing physician and patient mobility has led to a move toward internationalization of standards for physician competence. The Institute for International Medical Education proposed a set of outcome-based standards for student performance, which were then measured using three assessment tools in eight leading schools in China: a 150-item multiple-choice examination, a 15-station OSCE and a 16-item faculty observation form. The purpose of this study was to empanel a group of experts to determine whether international student-level performance standards could be set. The IIME convened an international panel of experts in student education with specialty and geographic diversity. The group was split into two, with each sub-group establishing standards independently. After a discussion of the borderline student, the sub-groups established minimally acceptable cut-off scores for performance on the multiple-choice examination (Angoff and Hofstee methods), the OSCE station and global rating performance (modified Angoff method and holistic criterion reference), and faculty observation domains (holistic criterion reference). Panelists within each group set very similar standards for performance. In addition, the two independent parallel panels generated nearly identical performance standards. Cut-off scores changed little before and after being shown pilot data but standard deviations diminished. International experts agreed on a minimum set of competences for medical student performance. In addition, they were able to set consistent performance standards with multiple examination types. This provides an initial basis against which to compare physician performance internationally.

  4. Modern Radiation Therapy for Hodgkin Lymphoma: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group (ILROG)

    SciTech Connect

    Specht, Lena; Yahalom, Joachim; Illidge, Tim; Berthelsen, Anne Kiil; Constine, Louis S.; Eich, Hans Theodor; Girinsky, Theodore; Hoppe, Richard T.; Mauch, Peter; Mikhaeel, N. George; Ng, Andrea

    2014-07-15

    use of ISRT has not yet been validated in a formal study, it is more conservative than INRT, accounting for suboptimal information and appropriately designed for safe local disease control. The goal of modern smaller field radiation therapy is to reduce both treatment volume and treatment dose while maintaining efficacy and minimizing acute and late sequelae. This review is a consensus of the International Lymphoma Radiation Oncology Group (ILROG) Steering Committee regarding the modern approach to RT in the treatment of HL, outlining a new concept of ISRT in which reduced treatment volumes are planned for the effective control of involved sites of HL. Nodal and extranodal non-Hodgkin lymphomas (NHL) are covered separately by ILROG guidelines.

  5. Internal derangements of the temporomandibular joint: findings in the pediatric age group

    SciTech Connect

    Katzberg, R.W.; Tallents, R.H.; Hayakawa, K.; Miller, T.L.; Goske, M.J.; Wood, B.P.

    1985-01-01

    Findings in 31 pediatric patients with pain and dysfunction of the temporomandibular joint (TMJ) are reported. The average age was 14 years and the average duration of symptoms was 21.4 months. Internal derangements were found in 29 patients (94%) and degenerative arthritis in 13 (42%). In 12 patients (39%), the problem could be traced to an injury to the jaw. Secondary condylar hypoplasia was associated with the meniscal abnormality in 3 patients (10%). Further awareness of internal derangements of the TMJ in the pediatric population should permit greater recognition of their etiology. It is important that threatment be initiated as soon as possible, not only to minimize the development of osseous disease in young adults but also to prevent facial growth deformities.

  6. When the group practice breaks up: a qualitative study

    PubMed Central

    2013-01-01

    Background Group practices are increasingly common for primary care physicians worldwide. Although breakups are likely to happen frequently within group practices, their process has not been studied to date. The aims of this study were therefore to explore the reasons for breakups of group practices of general practitioners and to describe the associated feelings. Methods We conducted a qualitative study consisting of in-depth interviews of 21 general practitioners and one secretary from past group practices in the Rhône-Alpes region, France, who experienced a breakup. Results When getting started in group practice for the first time, young doctors did not feel ready and supported, and did not necessarily share the same expectations as their partners. The reasons for the breakups involved imbalances within the groups, contrasting working and management styles, and breakdowns in communication. The breakup process often generated long-persistent feelings of suffering and failure for almost every partner who experienced a breakup, particularly for the partner who was leaving. Conclusions Weakening factors exist from the very beginning of a partnership, and problems are likely to increase at every change or event occurring in the group. We provide several recommendations, including fair management, a shared project based on a precise contract, the consultation of third parties as necessary and, in the worst case scenario, leaving the group practice in time. PMID:23642277

  7. The visiting internet Fiancé/ée (VIF): an emerging group of international travelers.

    PubMed

    Sofarelli, Theresa A; Birich, Holly K; Hale, DeVon C

    2014-01-01

    Here we describe an emerging category of travelers called the Visiting Internet Fiancé/ée (VIF), characterized by their travel to pursue a romantic relationship with an individual they have only encountered online. The VIF is not well identified in travel medicine literature despite having a higher risk for several travel-related issues including sexually transmitted infections, monetary fraud, and international scams. We also propose specific counseling interventions designed to minimize the adverse outcomes faced by the VIF traveler.

  8. Bion's thinking about groups: a study of influence and originality.

    PubMed

    Schneider, John A

    2015-04-01

    One of Bion's least-acknowledged contributions to psychoanalytic theory is his study of the relationship between the mind of the individual (the ability to think), the mentalities of groups of which the individual is a member, and the individual's bodily states. Bion's early work on group therapy evolved into a study of the interplay between mind and bodily instincts associated with being a member of a group, and became the impetus for his theory of thinking. On the foundation of Bion's ideas concerning this interaction among the thinking of the individual, group mentality, and the psyche-soma, the author presents his thoughts on the ways in which group mentality is recognizable in the analysis of individuals.

  9. Bion's thinking about groups: a study of influence and originality.

    PubMed

    Schneider, John A

    2015-04-01

    One of Bion's least-acknowledged contributions to psychoanalytic theory is his study of the relationship between the mind of the individual (the ability to think), the mentalities of groups of which the individual is a member, and the individual's bodily states. Bion's early work on group therapy evolved into a study of the interplay between mind and bodily instincts associated with being a member of a group, and became the impetus for his theory of thinking. On the foundation of Bion's ideas concerning this interaction among the thinking of the individual, group mentality, and the psyche-soma, the author presents his thoughts on the ways in which group mentality is recognizable in the analysis of individuals. PMID:25876541

  10. Gravity as an internal Yang-Mills gauge field theory of the Poincaré group.

    NASA Astrophysics Data System (ADS)

    Hennig, Jörg; Nitsch, Jürgen

    1981-10-01

    In the framework of affine bundles we present gravity as an “internal” gauge field theory of the Poincaré group. The resulting geometry is a Riemann-Cartan space-time carrying torsion and curvature. In order to admit a nontrivial action of the translation group we formally extend the matter Lagrangian to affine field variables. Finally, we establish the relation of our approach with the formalism of Hehl et al.

  11. International Myeloma Working Group molecular classification of multiple myeloma: spotlight review

    PubMed Central

    Fonseca, R; Bergsagel, PL; Drach, J; Shaughnessy, J.; Gutierrez, N; Stewart, AK; Morgan, G; Van Ness, B; Chesi, M; Minvielle, S; Neri, A; Barlogie, B; Kuehl, WM; Liebisch, P; Davies, F; Chen-Kiang, S; Durie, BGM; Carrasco, R; Sezer, Orhan; Reiman, Tony; Pilarski, Linda; Avet-Loiseau, H

    2010-01-01

    Myeloma is a malignant proliferation of monoclonal plasma cells. Although morphologically similar, several subtypes of the disease have been identified at the genetic and molecular level. These genetic subtypes are associated with unique clinico-pathological features and dissimilar outcome. At the top hierarchical level, myeloma can be divided into hyperdiploid and non-hyperdiploid subtypes. The latter is mainly composed of cases harboring IgH translocations, generally associated with more aggressive clinical features and shorter survival. The three main IgH translocations in myeloma are the t(11;14)(q13;q32), t(4;14)(p16;q32) and t(14;16)(q32;q23). Trisomies and a more indolent form of the disease characterize hyperdiploid myeloma. A number of genetic progression factors have been identified including deletions of chromosomes 13 and 17 and abnormalities of chromosome 1 (1p deletion and 1q amplification). Other key drivers of cell survival and proliferation have also been identified such as nuclear factor- B-activating mutations and other deregulation factors for the cyclin-dependent pathways regulators. Further understanding of the biological subtypes of the disease has come from the application of novel techniques such as gene expression profiling and array-based comparative genomic hybridization. The combination of data arising from these studies and that previously elucidated through other mechanisms allows for most myeloma cases to be classified under one of several genetic subtypes. This paper proposes a framework for the classification of myeloma subtypes and provides recommendations for genetic testing. This group proposes that genetic testing needs to be incorporated into daily clinical practice and also as an essential component of all ongoing and future clinical trials. PMID:19798094

  12. The Importance of Place for International Students' Choice of University: A Case Study at a Malaysian University

    ERIC Educational Resources Information Center

    Singh, Jasvir Kaur Nachatar; Schapper, Jan; Jack, Gavin

    2014-01-01

    The scholarly bias toward Western and English-speaking settings in the study of international education overlooks the experiences of international students in emerging education hubs in Asia. To redress this imbalance, this article offers insights into the crucial role of place in the study destination choices of a group of international…

  13. Boundary work for sustainable development: Natural resource management at the Consultative Group on International Agricultural Research (CGIAR).

    PubMed

    Clark, William C; Tomich, Thomas P; van Noordwijk, Meine; Guston, David; Catacutan, Delia; Dickson, Nancy M; McNie, Elizabeth

    2016-04-26

    Previous research on the determinants of effectiveness in knowledge systems seeking to support sustainable development has highlighted the importance of "boundary work" through which research communities organize their relations with new science, other sources of knowledge, and the worlds of action and policymaking. A growing body of scholarship postulates specific attributes of boundary work that promote used and useful research. These propositions, however, are largely based on the experience of a few industrialized countries. We report here on an effort to evaluate their relevance for efforts to harness science in support of sustainability in the developing world. We carried out a multicountry comparative analysis of natural resource management programs conducted under the auspices of the Consultative Group on International Agricultural Research. We discovered six distinctive kinds of boundary work contributing to the successes of those programs-a greater variety than has been documented in previous studies. We argue that these different kinds of boundary work can be understood as a dual response to the different uses for which the results of specific research programs are intended, and the different sources of knowledge drawn on by those programs. We show that these distinctive kinds of boundary work require distinctive strategies to organize them effectively. Especially important are arrangements regarding participation of stakeholders, accountability in governance, and the use of "boundary objects." We conclude that improving the ability of research programs to produce useful knowledge for sustainable development will require both greater and differentiated support for multiple forms of boundary work.

  14. The International Scientific Working Group on Tick-Borne Encephalitis (ISW TBE): Review of 17 years of activity and commitment.

    PubMed

    Kunze, Ursula

    2016-04-01

    Tick-borne encephalitis (TBE) has been a growing public health problem in Europe and other parts of the world for the past 20 years. In 1999, in order to encourage the control of TBE, international experts created a new body: The International Scientific Working Group on Tick-Borne Encephalitis (ISW-TBE). This Working Group has been composed of internationally recognized scientific experts from tick-borne encephalitis virus (TBEv)-endemic and non-endemic regions with extensive personal expertise in the field and a high level of commitment to improve the knowledge of TBE and to increase the public awareness of TBE. Since the foundation of the Working Group, ISW-TBE members meet annually. Every meeting is dedicated to a specific topic, and since 2004 a yearly conference report has been published to inform the scientific community about the latest developments. Among the specific issues that have been extensively discussed over the years were the following: clinical aspects of the disease, TBE in children and golden agers, epidemiology, possible causes for the increase in TBE incidence in Europe, TBE and awareness, TBE and travel, (low) vaccination rates, and the cooperation with the European Centre for Disease Prevention and Control (ECDC). This paper gives an overview of the most important activities and achievements of the ISW-TBE over the past 17 years. PMID:26795231

  15. Novice Teachers Learning through Participation in a Teacher Study Group

    ERIC Educational Resources Information Center

    Lambson, Dawn

    2010-01-01

    Using Lave and Wenger's framework of legitimate peripheral participation in communities of practice, this case study explores the experiences of three novice teachers engaged with more experienced teachers in a teacher study group during their first year of teaching. The study illustrates how, over time, the novices moved from more peripheral to…

  16. Children of mentally ill parents—a pilot study of a group intervention program

    PubMed Central

    Christiansen, Hanna; Anding, Jana; Schrott, Bastian; Röhrle, Bernd

    2015-01-01

    Objective: The transgenerational transmission of mental disorders is one of the most prominent risk factors for the development of psychological disorders. Children of mentally ill parents are a vulnerable high risk group with overall impaired development and high rates of psychological disorders. To date there are only a few evidence based intervention programs for this group overall and hardly any in Germany. We translated the evidence based Family Talk Intervention by Beardslee (2009) and adapted it for groups. First results of this pilot study are presented. Method: This investigation evaluates a preventive group intervention for children of mentally ill parents. In a quasi-experimental design three groups are compared: an intervention group (Family Talk Intervention group: n = 28), a Wait Control group (n = 9), and a control group of healthy children (n = 40). Mean age of children was 10.41 years and parental disorders were mostly depressive/affective disorders (n = 30), but a small number also presented with Attention-Deficit/Hyperactivity Disorder (n = 7). Results: Children of mentally ill parents showed higher rates of internalizing/externalizing disorders before and after the intervention compared to children of parents with no disorders. Post intervention children's knowledge on mental disorders was significantly enhanced in the Family Talk Intervention group compared to the Wait Control group and the healthy control group. Parental ratings of externalizing symptoms in the children were reduced to normal levels after the intervention in the Family Talk Intervention group, but not in the Wait Control group. Discussion: This pilot study of a group intervention for children of mentally ill parents highlights the importance of psycho-education on parental mental disorders for children. Long-term effects of children's enhanced knowledge about parental psychopathology need to be explored in future studies. PMID:26539129

  17. Genetic studies among endogamous groups of Saraswats in Western India.

    PubMed

    Bhatia, H M; Shanbhag, S R; Baxi, A J; Bapat, J; Sathe, M S; Sharma, R S; Kabeer, H; Bharucha, Z S; Surlacar, L

    1976-01-01

    Three groups of Saraswat Brahmans in Western India and a group of Goan Catholics ethnologically related to Saraswats were studied for various genetic markers. Saraswats have higher A than B with an Rh(D)-negative incidence ranging from 10 to 17%. All the groups have low incidence of G-6-PD deficiency (up to 1%). Incidence of thalassaemia trait ranges from 1 to 6%. Gm(1) was present in 85-87%. Intergroup differences suggest genetic closeness between the various groups with genetic distance ranging from 0.8 to 1.5. Genetic relationship between Goan Catholics and Chitrapur Saraswats confirms the ethnological and historical evidence of relationship between the two groups.

  18. Case stories in general practice: a focus group study

    PubMed Central

    Abildsnes, Eirik; Flottorp, Signe; Stensland, Per

    2012-01-01

    Objectives To explore the interactive process of sharing case stories in small-group activity in general practice. Design Qualitative focus group study. Setting Peer-group meetings of doctors attending specialist training or continuous medical education in general practice. Participants Twenty female and 30 male doctors working in general practice in Norway. Results The storyline of case presentations included detailed stories with emotional engagement, co-authored by other group members. The stories initiated discussions and reflections concerning patients’ and doctors’ perspectives, medical ethics as well as clinical problems. The safe atmosphere allowed testing out boundaries of socially shared knowledge. Conclusions Sharing case stories in small groups in general practice initiated interaction that facilitated meaning-making, reflection and peer support. PMID:22874630

  19. Gerald H. Read and the Development of Post-War International Study Tour and Seminar Programs.

    ERIC Educational Resources Information Center

    Ohles, John F.

    Gerald H. Read's interest in international education began as a child and was fostered by the artifacts collected by his father in his travels throughout Asia. He organized his first study tour abroad while he was a senior at Kent State University (Ohio) in 1936. In 1955, a group of educators who were interested in tours abroad for the purposes of…

  20. An advisory statement from the Pediatric Working Group of the International Liaison Committee on Resuscitation.

    PubMed

    Kattwinkel, J; Niermeyer, S; Nadkarni, V; Tibballs, J; Phillips, B; Zideman, D; Van Reempts, P; Osmond, M

    1999-04-01

    The International Liaison Committee on Resuscitation (ILCOR), with representation from North America, Europe, Australia, New Zealand, Africa, and South America, was formed in 1992 to provide a forum for liaison between resuscitation organizations in the developed world. This consensus document on resuscitation extends previously published ILCOR advisory statements on resuscitation to address the unique and changing physiology of the newly born infant within the first few hours after birth and the techniques for providing advanced life support. After careful review of the international resuscitation literature and after discussion of key and controversial issues, consensus was reached on almost all aspects of neonatal resuscitation, and areas of controversy and high priority for additional research were delineated. Consensus on resuscitation for the newly born infant included the following principles: Common or controversial medications (epinephrine, volume expansion, naloxone, bicarbonate), special resuscitation circumstances affecting care of the newly born, continuing care of the newly born after resuscitation, and ethical considerations for initiation and discontinuation of resuscitation are discussed. There was agreement that insufficient data exist to recommend changes to current guidelines regarding the use of 21% versus 100% oxygen, neuroprotective interventions such as cerebral hypothermia, use of a laryngeal mask versus endotracheal tube, and use of high-dose epinephrine. Areas of controversy are identified, as is the need for additional research to improve the scientific justification of each component of current and future resuscitation guidelines. PMID:10103348

  1. Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules

    DOEpatents

    Adamec, Jiri; Yang, Wen-Chu; Regnier, Fred E

    2014-01-14

    Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distince forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.

  2. Direct and Nondirect Marathon Group Therapy and Internal---External Control

    ERIC Educational Resources Information Center

    Kilmann, Peter R.

    1974-01-01

    Investigates whether direct and nondirect therapist techniques within a 23-hour marathon format would differentially induce client shifts in locus of control. The no-treatment control group experienced a significant shift toward externality, while the marathon subjects did not fluctuate significantly from pretherapy to posttherapy. (Author)

  3. Influence of an internal trifluoromethyl group on the rhodium(II)-catalyzed reactions of vinyldiazocarbonyl compounds.

    PubMed

    Nikolaev, Valerij A; Supurgibekov, Murat B; Davies, Huw M L; Sieler, Joachim; Zakharova, Valerija M

    2013-05-01

    Incorporation of a trifluoromethyl group into the structure of 4-(alkoxycarbonyl)vinyldiazocarbonyl compounds greatly decreases the tendency of the carbenoid intermediates formed during Rh(II)-catalyzed reactions to undergo intermolecular processes. Instead, they are prone to experience intramolecular [1,5]- and [1,3]-electrocyclizations to produce reactive cyclopropenes and furans, and these are capable of further transformations. PMID:23614681

  4. The Referential Function of Internal Communication Groups in Complex Organizations: An Empirical Analysis.

    ERIC Educational Resources Information Center

    Taylor, James A.; Farace, Richard V.

    This paper argues that people who interact regularly and repetitively among themselves create a conjoint information space wherein common values, attitudes, and beliefs arise through the process of information transmission among the members in the space. Three major hypotheses concerning informal communication groups in organizations were tested…

  5. Group Work during International Disaster Outreach Projects: A Model to Advance Cultural Competence

    ERIC Educational Resources Information Center

    West-Olatunji, Cirecie; Henesy, Rachel; Varney, Melanie

    2015-01-01

    Given the rise in disasters worldwide, counselors will increasingly be called upon to respond. Current accreditation standards require that programs train students to become skillful in disaster/crisis interventions. Group processing to enhance self-awareness and improve conceptualization skills is an essential element of such training. This…

  6. The Lumad and Moro of Mindanao. Minority Rights Group International Report 93/2.

    ERIC Educational Resources Information Center

    Rodil, B. R.

    This document analyzes the two main indigenous groups in the south of the Philippines. It outlines the history of the Lumad and Moro communities of Mindanao. The document discusses the effects of development and business interests in the region, and their campaigns around land issues. The Lumad and Moro accept the need to develop new sources of…

  7. The elusive concept of 'internal objects' (1934-1943). Its role in the formation of the Klein Group.

    PubMed

    Hinshelwood, R D

    1997-10-01

    The author traces a debate about the concept of 'internal objects' that took place between 1937 and 1943 at a time when a group of British analysts was forming around Melanie Klein. The debate is set within a complex of personal, group and organisational dynamics, which the paper makes a start on unravelling. The history of the British Psycho-Analytical Society at this time exemplifies Bion's notion of group schism. The events in the Society's history demonstrate defensive aspects of the interaction between the opposed groups, which support members against various anxieties. These include the stress of the work of analysis, but also in this instance the particular anxieties deriving from the collapse of psychoanalysis in Europe, the state of war of the country as a whole, and the death of Freud shortly after he came to London. This psychoanalytic anxiety/defence model clarifies some aspects of the debate about internal objects, and demonstrates the way in which these various anxieties and defences become organised around a scientific debate in a scientific society.

  8. The elusive concept of 'internal objects' (1934-1943). Its role in the formation of the Klein Group.

    PubMed

    Hinshelwood, R D

    1997-10-01

    The author traces a debate about the concept of 'internal objects' that took place between 1937 and 1943 at a time when a group of British analysts was forming around Melanie Klein. The debate is set within a complex of personal, group and organisational dynamics, which the paper makes a start on unravelling. The history of the British Psycho-Analytical Society at this time exemplifies Bion's notion of group schism. The events in the Society's history demonstrate defensive aspects of the interaction between the opposed groups, which support members against various anxieties. These include the stress of the work of analysis, but also in this instance the particular anxieties deriving from the collapse of psychoanalysis in Europe, the state of war of the country as a whole, and the death of Freud shortly after he came to London. This psychoanalytic anxiety/defence model clarifies some aspects of the debate about internal objects, and demonstrates the way in which these various anxieties and defences become organised around a scientific debate in a scientific society. PMID:9459092

  9. Reverse Discrimination by Minority Groups. A Participant Observation Study.

    ERIC Educational Resources Information Center

    Clavner, Jerry B.; Clavner, Catherine

    This study explores reverse discrimination as a cultural phenomenon that should be studied by anthropologists, and to which anthropology has inadvertently contributed. Discrimination by minority group members is taught and encouraged under the guise of ethnic pride and promotion of traditional beliefs. Ethnocentrism may be a cultural defense…

  10. Motivating Study Groups across the Disciplines in Secondary Schools

    ERIC Educational Resources Information Center

    Styslinger, Mary E.; Clary, Deidre M.; Oglan, Victoria A.

    2015-01-01

    This article introduces Project RAISSE: Reading Assistance Initiative for Secondary School Educators and shares the findings of a study into those factors found to motivate study group participants at two rural high schools in the southern USA. The research team collected qualitative data over a two-year period, including interviews, artifacts,…

  11. Developing Dialogic Teaching Identities through Online Video Study Groups

    ERIC Educational Resources Information Center

    Black, Nathan Jeffrey

    2012-01-01

    This study explores how teachers narrate and develop their identities through their participation in an online video study group. Participants are six public school world language teachers using "Teaching Proficiency through Reading and Storytelling" (TPRS) methodology who live in geographically diverse regions of the United States but…

  12. Practicing Social Movement Theory in Case Study Groups

    ERIC Educational Resources Information Center

    Ormrod, James S.

    2011-01-01

    This article evaluates the use of a "case study group" method for teaching social movement theory. The aim was to give students the opportunity to practice theorizing actively rather than simply learning theory passively. The method provides this by requiring students to undertake case studies on social movements of their choice for the duration…

  13. Study: California Ethnic Groups Seeing Increased Cancer Rates

    ERIC Educational Resources Information Center

    Black Issues in Higher Education, 2005

    2005-01-01

    A statewide study on cancer and ethnicity hints that cancer rates among immigrant groups may be tied to their degree of assimilation into American culture. The study, released by the University of Southern California's Norris Comprehensive Cancer Center, marks the first statewide look at cancer rates among Vietnamese and South Asians and provides…

  14. Analytical study of spacecraft deposition contamination by internal reflection spectroscopy

    NASA Technical Reports Server (NTRS)

    Mookherji, T.

    1972-01-01

    Infrared absorption spectra of ten individual contaminant materials and four binary mixtures of these have been studied using the internal reflection spectroscopy technique. The effect of ultraviolet radiation on these contaminants has also been studied. It has been observed that all siloxanes, silanes, and esters are drastically affected by ultraviolet irradiation. In most cases polymerization and tar formation results.

  15. International Studies a Hard Sell in U.S.

    ERIC Educational Resources Information Center

    Manzo, Kathleen Kennedy

    2005-01-01

    North Carolina boasts a growing network of global-studies magnet schools, a prominent university center that sponsors training on international issues and study trips abroad for thousands of teachers, an innovative recruitment program to attract teachers from around the globe, and a popular former governor who has championed the cause of …

  16. Undergraduate Students' Conceptions of Mathematics: An International Study

    ERIC Educational Resources Information Center

    Petocz, Peter; Reid, Anna; Wood, Leigh N.; Smith, Geoff H.; Mather, Glyn; Harding, Ansie; Engelbrecht, Johann; Houston, Ken; Hillel, Joel; Perrett, Gillian

    2007-01-01

    In this paper, we report on an international study of undergraduate mathematics students; conceptions of mathematics. Almost 1,200 students in five countries completed a short survey including three open-ended questions asking about their views of mathematics and its role in their future studies and planned professions. Responses were analysed…

  17. International Exchange as a Transformative Learning Experience: A Case Study

    ERIC Educational Resources Information Center

    Choi, Sheena; Slaubaugh, Michael; Kim, Ae-Sook

    2012-01-01

    This study examines the role of international exchange programs on the transformative learning of English-speaking students. A student exchange program at a South Korean university is used for this case study. It explores how learning experiences are translated by participants onto their perceptions about the host country. An analysis of a pre-…

  18. Infusing International Studies into the Community College Curriculum.

    ERIC Educational Resources Information Center

    Harris, Mathilda E.

    Mount Hood Community College (MHCC), with financial support from the Department of Health, Education, and Welfare (DHEW), implemented a three-year project in 1979 designed to infuse international studies into the college's liberal arts and vocational curricula. Planning for the project began after the successful implementation of a study abroad…

  19. International Computer and Information Literacy Study: Assessment Framework

    ERIC Educational Resources Information Center

    Fraillon, Julian; Schulz, Wolfram; Ainley, John

    2013-01-01

    The purpose of the International Computer and Information Literacy Study 2013 (ICILS 2013) is to investigate, in a range of countries, the ways in which young people are developing "computer and information literacy" (CIL) to support their capacity to participate in the digital age. To achieve this aim, the study will assess student…

  20. Journaling and Self-Study in an International Research Collective

    ERIC Educational Resources Information Center

    Makaiau, Amber Strong; Leng, Lu; Fukui, Suguru

    2015-01-01

    Drawing from the theoretical foundations of reflective teaching, culturally responsive education, social constructivism, and self-study, this collaborative self-study investigates the role of an interactive online journal in an international research collective. Each from a different country, the authors came together through a common interest in…

  1. Report of the International Astronomical Union Division I Working Group on Precession and the Ecliptic

    NASA Astrophysics Data System (ADS)

    Hilton, J. L.; Capitaine, N.; Chapront, J.; Ferrandiz, J. M.; Fienga, A.; Fukushima, T.; Getino, J.; Mathews, P.; Simon, J.-L.; Soffel, M.; Vondrak, J.; Wallace, P.; Williams, J.

    2006-03-01

    The IAU Working Group on Precession and the Equinox looked at several solutions for replacing the precession part of the IAU 2000A precession nutation model, which is not consistent with dynamical theory. These comparisons show that the (Capitaine et al., Astron. Astrophys., 412, 2003a) precession theory, P03, is both consistent with dynamical theory and the solution most compatible with the IAU 2000A nutation model. Thus, the working group recommends the adoption of the P03 precession theory for use with the IAU 2000A nutation. The two greatest sources of uncertainty in the precession theory are the rate of change of the Earth’s dynamical flattening, ΔJ 2, and the precession rates (i.e. the constants of integration used in deriving the precession). The combined uncertainties limit the accuracy in the precession theory to approximately 2 mas cent-2.

  2. 75 FR 3953 - Notice of Meeting of a Study Group of the U.S. Department of State Advisory Committee on Private...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Notice of Meeting of a Study Group of the U.S. Department of State Advisory Committee on Private International Law A Study Group of the Department of State Advisory Committee on Private International Law (ACPIL) will hold a public meeting to continue...

  3. International Space Exploration Coordination Group Assessment of Technology Gaps for LOx/Methane Propulsion Systems for the Global Exploration Roadmap

    NASA Technical Reports Server (NTRS)

    Hurlbert, Eric A.; Whitley, Ryan; Klem, Mark D.; Johnson, Wesley; Alexander, Leslie; D'Aversa, Emanuela; Ruault, Jean-Marc; Manfletti, Chiara; Caruana, Jean-Noel; Ueno, Hiroshi; Asakawa, Hiroya

    2016-01-01

    As part of the Global Exploration Roadmap (GER), the International Space Exploration Coordination Group (ISECG) formed two technology gap assessment teams to evaluate topic discipline areas that had not been worked at an international level to date. The participating agencies were ASI, CNES, DLR, ESA, JAXA, and NASA. Accordingly, the ISECG Technology Working Group (TWG) recommended two discipline areas based on Critical Technology Needs reflected within the GER Technology Development Map (GTDM): Dust Mitigation and LOX/Methane Propulsion. LOx/Methane propulsion systems are enabling for future human missions Mars by significantly reducing the landed mass of the Mars ascent stage through the use of in-situ propellant production, for improving common fluids for life support, power and propulion thus allowing for diverse redundancy, for eliminating the corrosive and toxic propellants thereby improving surface operations and resusabilty, and for inceasing the performance of propulsion systems. The goals and objectives of the international team are to determine the gaps in technology that must be closed for LOx/Methane to be used in human exploration missions in cis-lunar, lunar, and Mars mission applications. An emphasis is placed on near term lunar lander applications with extensibility to Mars. Each agency provided a status of the substantial amount of Lox/Methane propulsion system development to date and their inputs on the gaps in the technology that are remaining. The gaps, which are now opportunities for collaboration, are then discussed.

  4. Computational study on the internal layer in a diffuser

    NASA Astrophysics Data System (ADS)

    Wu, Xiaohua

    2005-11-01

    We report an internal layer found in the turbulent flow through an asymmetric planar diffuser using large eddy simulation; we discuss five issues relevant to the internal layer: definition and identification, conditions for occurrence, connection with its outer flow, similarity with other equilibrium flows, and growth. The present internal layer exists in a region with stabilized positive skin friction downstream of a sharp reduction. The streamwise pressure gradient changes suddenly from slightly favorable to strongly adverse at the diffuser throat, and relaxes in a prolonged mildly adverse region corresponding to the skin friction plateau. Signatures of the internal layer include inflectional point in the wall-normal profiles of streamwise turbulence intensity, and a well-defined logarithmic slope in mean streamwise velocity underneath a linear distribution extending to the core region of the diffuser. It is interesting to note that some of these characteristics bear certain resemblance to those existing in the C-type of Couette-Poiseuille turbulent flows. Two point correlations with streamwise, wall-normal and temporal separations were used to examine connections between fluctuations inside the internal layer and those in the core region of the diffuser. The internal layer discovered from this study provides qualified support to a conjecture advanced by Azad and Kassab fifteen years ago.

  5. Crafting an International Study of Students' Conceptual Understanding of Astronomy

    NASA Astrophysics Data System (ADS)

    Slater, Stephanie; Bretones, P. S.; McKinnon, D.; Schleigh, S.; Slater, T. F.; Astronomy, Center; Education Research, Physics

    2013-01-01

    Large international investigations into the learning of science, such as the TIMSS and PISA studies, have been enlightening with regard to effective instructional practices. Data from these studies revealed weaknesses and promising practices within nations' educational systems, with evidence to suggest that these studies have led to international reforms in science education. However, these reforms have focused on the general characteristics of teaching and learning across all sciences. While extraordinarily useful, these studies have provided limited insight for any given content domain. To date, there has been no systematic effort to measure individual's conceptual astronomy understanding across the globe. This paper describes our motivations for a coordinated, multinational study of astronomy understanding. First, reformed education is based upon knowing the preexisting knowledge state of our students. The data from this study will be used to assist international astronomy education and public outreach (EPO) professionals in their efforts to improve practices across global settings. Second, while the US astronomy EPO community has a long history of activity, research has established that many practices are ineffective in the face of robust misconceptions (e.g.: seasons). Within an international sample we hope to find subpopulations that do not conform to our existing knowledge of student misconceptions, leading us to cultural or educational practices that hint at alternative, effective means of instruction. Finally, it is our hope that this first venture into large-scale disciplinary collaboration will help us to craft a set of common languages and practices, building capacity and leading toward long-term cooperation across the international EPO community. This project is sponsored and managed by the Center for Astronomy & Physics Education Research (CAPER), in collaboration with members of the International Astronomical Union-Commission 46. We are actively

  6. The International Design Study for the Neutrino Factory

    SciTech Connect

    Long, K.

    2008-02-21

    The International Design Study for a future Neutrino Factory and super-beam facility (the ISS) established the physics case for a high-precision programme of long-baseline neutrino-oscillation measurements. The ISS also identified baseline specifications for the Neutrino Factory accelerator complex and the neutrino detector systems. This paper summarises the objectives of the International Design Study for the Neutrino Factory (the IDS-NF). The IDS-NF will build on the work of the ISS to deliver a Reference Design Report for the Neutrino Factory by 2012/13 and an Interim Design Report by 2010/11.

  7. Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project

    PubMed Central

    Avet-Loiseau, H; Durie, BGM; Cavo, M; Attal, M; Gutierrez, N; Haessler, J; Goldschmidt, H; Hajek, R; Lee, JH; Sezer, O; Barlogie, B; Crowley, J; Fonseca, R; Testoni, N; Ross, F; Rajkumar, SV; Sonneveld, P; Lahuerta, J; Moreau, P; Morgan, G

    2014-01-01

    The combination of serum β2-microglobulin and albumin levels has been shown to be highly prognostic in myeloma as the International Staging System (ISS). The aim of this study was to assess the independent contributions of ISS stage and cytogenetic abnormalities in predicting outcomes. A retrospective analysis of international studies looking at both ISS and cytogenetic abnormalities was performed in order to assess the potential role of combining ISS stage and cytogenetics to predict survival. This international effort used the International Myeloma Working Group database of 12 137 patients treated worldwide for myeloma at diagnosis, of whom 2309 had cytogenetic studies and 5387 had analyses by fluorescent in situ hybridization (iFISH). Comprehensive analyses used 2642 patients with sufficient iFISH data available. Using the comprehensive iFISH data, combining both t(4;14) and deletion (17p), along with ISS stage, significantly improved the prognostic assessment in terms of progression-free survival and overall survival. The additional impact of patient age and use of high-dose therapy was also demonstrated. In conclusion, the combination of iFISH data with ISS staging significantly improves risk assessment in myeloma. PMID:23032723

  8. The CSNI/PWG-1 international task group on ECCS reliability

    SciTech Connect

    Sandervag, O.; Riekert, T.; Serkiz, A.; Hyvarinen, J.

    1996-03-01

    A steam line loss-of-coolant accident (LOCA) occurred when a safety relief valve inadvertently opened in the Barseback-2 nuclear power plant. The steam jet stripped fibrous insulation from adjacent pipework. Part of that insulation debris was transported to the wetwell pool and clogged the intake strainers for the drywell spray system after about one hour. Although the incident in itself was not very serious, it revealed a weakness in the defense-in-depth concept which under other circumstances could have led to failure of the emergency core cooling system (ECCS) to provide water to the core. Before the Barseback-2 LOCA, international regulators of nuclear power plants and the nuclear power plant industry had considered safety questions related to strainer clogging as resolved. Many European countries had followed the guidance for strainers in pressurized water reactors (PWRs) contained in United States Nuclear Regulatory Commission`s (USNRC) Regulatory Guide 1.82, Water Sources for Long Term Recirculation Cooling Following a Loss-of-Coolant Accident, 1974. However, data obtained from European experimental programs carried out in the late seventies to determine the performance of strainers indicated that this guide was not adequate. In addition, Swedish plant owners had used this guidance to judge performance of emergency core cooling systems (ECCS) in their plants. Analyses at that time had indicated that strainer clogging, if occurring at all, would at least not occur during the first ten hours after a LOCA. Since operation of the ECCS would be needed for a long time, backflushing capabilities and monitors of pressure drop across the strainers were installed in older Swedish BWR plants with small strainer areas. These actions were judged to be adequate compliance with the revised USNRC Regulatory Guide 1.82, Rev. 1, issued in 1985. Safety questions related to strainer clogging were considered to have been resolved until the incident happened in Barseback-2.

  9. Boundary work for sustainable development: Natural resource management at the Consultative Group on International Agricultural Research (CGIAR)

    PubMed Central

    Clark, William C.; Tomich, Thomas P.; van Noordwijk, Meine; Guston, David; Catacutan, Delia; Dickson, Nancy M.; McNie, Elizabeth

    2016-01-01

    Previous research on the determinants of effectiveness in knowledge systems seeking to support sustainable development has highlighted the importance of “boundary work” through which research communities organize their relations with new science, other sources of knowledge, and the worlds of action and policymaking. A growing body of scholarship postulates specific attributes of boundary work that promote used and useful research. These propositions, however, are largely based on the experience of a few industrialized countries. We report here on an effort to evaluate their relevance for efforts to harness science in support of sustainability in the developing world. We carried out a multicountry comparative analysis of natural resource management programs conducted under the auspices of the Consultative Group on International Agricultural Research. We discovered six distinctive kinds of boundary work contributing to the successes of those programs—a greater variety than has been documented in previous studies. We argue that these different kinds of boundary work can be understood as a dual response to the different uses for which the results of specific research programs are intended, and the different sources of knowledge drawn on by those programs. We show that these distinctive kinds of boundary work require distinctive strategies to organize them effectively. Especially important are arrangements regarding participation of stakeholders, accountability in governance, and the use of “boundary objects.” We conclude that improving the ability of research programs to produce useful knowledge for sustainable development will require both greater and differentiated support for multiple forms of boundary work. PMID:21844351

  10. PREFACE: The International Workshop on Positron Studies of Defects 2014

    NASA Astrophysics Data System (ADS)

    Sugita, Kazuki; Shirai, Yasuharu

    2016-01-01

    The International Workshop on Positron Studies of Defects 2014 (PSD-14) was held in Kyoto, Japan from 14-19 September, 2014. The PSD Workshop brought together positron scientists interested in studying defects to an international platform for presenting and discussing recent results and achievements, including new experimental and theoretical methods in the field. The workshop topics can be characterized as follows: • Positron studies of defects in semiconductors and oxides • Positron studies of defects in metals • New experimental methods and equipment • Theoretical calculations and simulations of momentum distributions, positron lifetimes and other characteristics for defects • Positron studies of defects in combination with complementary methods • Positron beam studies of defects at surfaces, interfaces, in sub-surface regions and thin films • Nanostructures and amorphous materials

  11. Computational study on the internal layer in a diffuser

    NASA Astrophysics Data System (ADS)

    Wu, Xiaohua; Schlüter, Jörg; Moin, Parviz; Pitsch, Heinz; Iaccarino, Gianluca; Ham, Frank

    2006-03-01

    reveals a string of well-defined spanwise vortices outside the internal layer. The internal layer discovered from this study provides qualified support for a conjecture advanced by Azad & Kassab some years ago (Phys. Fluids A, vol. 1, 1989, p. 564).

  12. NORTHEAST LOON STUDY WORKING GROUP PARTNERSHIP TO ASSESS ENVIRONMENTAL RISK

    EPA Science Inventory

    The Northeast Loon Study Working Group (NELSWG) was formed in 1994 to proactively identify threats to one of the Northeast's most popular waterbirds, the common loon, Gavia immer. Seventeen institutions have come together to identify strategy, coordinate the work load, and share ...

  13. Cognitive group therapy for depressive students: The case study

    PubMed Central

    Tiuraniemi, Juhani; Korhola, Jarno

    2009-01-01

    The aims of this study were to assess whether a course of cognitive group therapy could help depressed students and to assess whether assimilation analysis offers a useful way of analysing students' progress through therapy. “Johanna” was a patient in a group that was designed for depressive students who had difficulties with their studies. The assimilation of Johanna's problematic experience progressed as the meetings continued from level one (unpleasant thoughts) to level six (solving the problem). Johanna's problematic experience manifested itself as severe and excessive criticism towards herself and her study performance. As the group meetings progressed, Johanna found a new kind of tolerance that increased her determination and assertiveness regarding the studies. The dialogical structure of Johanna's problematic experience changed: she found hope and she was more assertive after the process. The results indicated that this kind of psycho-educational group therapy was an effective method for treating depression. The assimilation analysis offered a useful way of analysing the therapy process. PMID:20523883

  14. Faculty-Study Groups Support School Improvement Efforts

    ERIC Educational Resources Information Center

    Hilliard, Ann

    2009-01-01

    This article focuses on effective professional interactions of teachers and administrators as faculty-study groups in school improvement practices and educational reform to improve instruction and learning. The emphasis on practical approach promises to create conditions for continuous systemic change and academic improvement. The author…

  15. FINAL REPORT: NATIONAL CHILDREN'S STUDY FOCUS GROUPS - FOLLOW-UP

    EPA Science Inventory

    The purpose of this work assignment was to add to our knowledge of the issues that will affect

    recruitment and retention of pregnant women into the National Children's Study by conducting 14 focus

    groups comprised of pregnant women, couples, and parents of young chi...

  16. Effective Single-Parent Training Group Program: Three System Studies

    ERIC Educational Resources Information Center

    Briggs, Harold E.; Miller, Keva M.; Orellana, E. Roberto; Briggs, Adam C.; Cox, Wendell H.

    2013-01-01

    Objective: This study highlights Dr. Elsie Pinkston and colleagues' research on the effectiveness of behavior parent training and examines the application of single-parent training group (SPG) programs to three parent-child dyads exposed to distressed family circumstances. Methods: Single-system evaluation designs were conducted with two…

  17. Political Economies of Health: A Consideration for International Nursing Studies

    ERIC Educational Resources Information Center

    Peters, Michael A.; Drummond, John S.

    2008-01-01

    This article introduces and explores the concept of political economy. In particular it focuses upon the political economy of health while also considering the implications for international nursing studies in the context of health care more generally. Political economy is not only about budgets, resources and policy. It is also about particular…

  18. Equivalence of Translations in International Reading Literacy Studies

    ERIC Educational Resources Information Center

    Arffman, Inga

    2010-01-01

    Recent years have witnessed a significant increase in the interest in international assessments of student performance. In such assessments it is mandatory that all the different-language texts be equivalent to each other, that is, equally difficult to understand. The article summarizes a study made on the topic, examining the problems of…

  19. Case Studies of Eight Texas Schools Implementing International Baccalaureate Programs

    ERIC Educational Resources Information Center

    Stillisano, Jacqueline R.; Waxman, Hersh C.; Hostrup, Judy; Rollins, Kayla Braziel

    2011-01-01

    This qualitative case study focused on the efficacy of International Baccalaureate Primary Years and Middle Years Programs in Texas schools and the extent to which the unique aspects of these programs contribute to positive student outcomes. The qualitative data were gathered as a complement to statistical, quantitative data our research team…

  20. Studies of the Reflection, Refraction and Internal Reflection of Light

    ERIC Educational Resources Information Center

    Lanchester, P. C.

    2014-01-01

    An inexpensive apparatus and associated experiments are described for studying the basic laws of reflection and refraction of light at an air-glass interface, and multiple internal reflections within a glass block. In order to motivate students and encourage their active participation, a novel technique is described for determining the refractive…

  1. Language and Anxiety: An Ethnographic Study of International Postgraduate Students

    ERIC Educational Resources Information Center

    Brown, Lorraine

    2008-01-01

    This paper presents some findings from an ethnographic study of international postgraduate students at a university in the South of England, which involved interviews and participant observation over a 12-month academic year. One of the major themes that emerged from this research was students' anxiety over their level of English language.…

  2. Whither Thou Goest: The Intrigue of an International Study Seminar.

    ERIC Educational Resources Information Center

    Patten, Ronald J.; Peters, Robert

    This paper describes one business school's response to the challenges of globalization. After faculty members taught seminars in other countries, an interest was expressed in conducting international study seminars for the school's business students. One-week seminars were arranged, which allowed part-time, employed MBA students to enroll. The…

  3. Science Education in Nineteen Countries. International Studies in Evaluation I.

    ERIC Educational Resources Information Center

    Comber, L. C.; Keeves, John P.

    This volume is the result of a study conducted by the International Association for the Evaluation of Educational Achievement (IEA) as part of the Six Subject Survey in Science, Literature, Reading Comprehension, English and French as Foreign Languages, and Civic Education. The project was begun in 1966 with the first phase of instrument…

  4. 1976-77 Internal Revenue Service Comparison Study. Final Report.

    ERIC Educational Resources Information Center

    Applied Management Sciences, Inc., Silver Spring, MD.

    Application forms for the Basic Educational Opportunity Grant (BEOG) program for 1976-1977 were compared to 1975 tax forms filed with the Internal Revenue Service (IRS). Comparisons were also made to data from a similar 1974-1975 study. Based on a sample of 212,263 applicants, findings include the following: during 1976-1977, 70.7 percent of all…

  5. 1979-80 Internal Revenue Service Comparison Study. Final Report.

    ERIC Educational Resources Information Center

    Applied Management Sciences, Inc., Silver Spring, MD.

    Application forms for the Basic Educational Opportunity Grant (BEOG) program for 1979-1980 were compared to 1978 tax forms filed with the Internal Revenue Service (IRS). Comparisons were also made to data from similar 1974-1975 and 1976-1977 studies. Based on a sample of 407,596 applicants, findings include the following: between 1976-1977 and…

  6. Crossing the Line: A Qualitative Study of Administrative Interns' Experiences

    ERIC Educational Resources Information Center

    Lehman, Lynn; Quick, Marilynn

    2011-01-01

    Internships serve as the bridge that spans the divide between being a teacher and an administrator. Most research on internships has emphasized the technical aspect of this experience, such as benefits and limitations of internships. The overall impact an internship experience has on an intern has been studied less extensively. This research study…

  7. Study of Interns' Perception of and Satisfaction with Experiential Learning

    ERIC Educational Resources Information Center

    Moran, Timothy J.

    2013-01-01

    The purpose of this study is to explore and analyze the factors that influence interns' perceptions of and satisfaction with experiential learning during the internship process. Internship programs have existed for over 100 years and are used extensively in higher education, particularly in business schools; there is very little evidence to…

  8. Culminating Cultural Studies with an International Christmas Fair.

    ERIC Educational Resources Information Center

    Sesow, F. Wm.

    1983-01-01

    Describes the "International Christmas Fair" developed as a part of "Project Explore: Cultural Studies" program in Fairmont, Nebraska, with an ESEA Title IV grant. Shows how a rural school teaches about the Christmas customs of Holland, Sweden, Mexico, Germany, Colonial America, and England. (AH)

  9. The International Institute for Labour Studies: Appraisal and Forward Look.

    ERIC Educational Resources Information Center

    Cox, Robert W.

    An appraisal is made of work accomplished by the International Institute for Labour Studies during the period 1965-1970, and guidelines for future development are suggested. Educational work accomplished by the institute since 1965 followed the general purpose of providing leadership education for those in labor and social policy fields. Related…

  10. On-The-Job Training for Minorities: An Internal Study.

    ERIC Educational Resources Information Center

    Frank, Harold Hillel

    This study used not only formal interviews, questionnaires, and attitude surveys, but also observations and informal interviews, to evaluate the internal workings of a secretarial and clerical skill training program for nonwhite women. Most data came from over 1,000 two to five minute observations of trainees during the on the job phase of…

  11. International Students' Likelihood to Seek Counseling While Studying Abroad

    ERIC Educational Resources Information Center

    Onabule, Adebayo I.; Boes, Susan R.

    2013-01-01

    International students experience significant stressors while studying in American colleges and universities, yet they use psychological services far less than domestic students (Misra & Castillo, 2004). Factors such as previous experience with counseling, perceived effectiveness of counseling style, and nationality were found to be factors…

  12. Boiling-Water Reactor internals aging degradation study. Phase 1

    SciTech Connect

    Luk, K.H.

    1993-09-01

    This report documents the results of an aging assessment study for boiling water reactor (BWR) internals. Major stressors for BWR internals are related to unsteady hydrodynamic forces generated by the primary coolant flow in the reactor vessel. Welding and cold-working, dissolved oxygen and impurities in the coolant, applied loads and exposures to fast neutron fluxes are other important stressors. Based on results of a component failure information survey, stress corrosion cracking (SCC) and fatigue are identified as the two major aging-related degradation mechanisms for BWR internals. Significant reported failures include SCC in jet-pump holddown beams, in-core neutron flux monitor dry tubes and core spray spargers. Fatigue failures were detected in feedwater spargers. The implementation of a plant Hydrogen Water Chemistry (HWC) program is considered as a promising method for controlling SCC problems in BWR. More operating data are needed to evaluate its effectiveness for internal components. Long-term fast neutron irradiation effects and high-cycle fatigue in a corrosive environment are uncertainty factors in the aging assessment process. BWR internals are examined by visual inspections and the method is access limited. The presence of a large water gap and an absence of ex-core neutron flux monitors may handicap the use of advanced inspection methods, such as neutron noise vibration measurements, for BWR.

  13. A study of the current group evaporation/combustion theories

    NASA Technical Reports Server (NTRS)

    Shen, Hayley H.

    1990-01-01

    Liquid fuel combustion can be greatly enhanced by disintegrating the liquid fuel into droplets, an effect achieved by various configurations. A number of experiments carried out in the seventies showed that combustion of droplet arrays and sprays do not form individual flames. Moreover, the rate of burning in spray combustion greatly deviates from that of the single combustion rate. Such observations naturally challenge its applicability to spray combustion. A number of mathematical models were developed to evaluate 'group combustion' and the related 'group evaporation' phenomena. This study investigates the similarity and difference of these models and their applicability to spray combustion. Future work that should be carried out in this area is indicated.

  14. Submicron Organic Aerosol Function Groups during the International Chemistry Experiment in the Arctic LOwer Troposphere (ICEALOT)

    NASA Astrophysics Data System (ADS)

    Russell, L. M.; Shaw, P. M.; Quinn, P. K.; Bates, T. S.

    2008-12-01

    Aerosol organic mass (OM) components are expected to have significant direct and indirect impacts on Arctic climate, especially during springtime Arctic haze. The chemical and physical properties of OM in Arctic aerosol remain largely unconstrained. The R/V Knorr traveled between Iceland and the Barents Sea during the ice-free months of March and April of 2008 and collected submicron particles on teflon filters for Fourier Transform Infrared (FTIR) spectroscopy to identify and quantify organic functional groups. Time series and composition are presented along with air mass back trajectories to indicate source regions. Early findings identify alcohols, alkanes, and carboxylic acids, with smaller amounts of amines, aromatics, alkenes and carbonyls. These data show the important contributions of organic oxygen and nitrogen in the Arctic region. Single particle analysis by Near-edge X-ray Absorption Fine Structure (NEXAFS) Scanning Transmission X- ray Microscopy (STXM) provides additional information about the distribution and morphology of the types of organic particles. Comparison to collocated simultaneous measurements by other techniques showed good agreement for OM and oxygenated organic fractions.

  15. Management of prostate cancer in older patients: updated recommendations of a working group of the International Society of Geriatric Oncology.

    PubMed

    Droz, Jean-Pierre; Aapro, Matti; Balducci, Lodovico; Boyle, Helen; Van den Broeck, Thomas; Cathcart, Paul; Dickinson, Louise; Efstathiou, Eleni; Emberton, Mark; Fitzpatrick, John M; Heidenreich, Axel; Hughes, Simon; Joniau, Steven; Kattan, Michael; Mottet, Nicolas; Oudard, Stéphane; Payne, Heather; Saad, Fred; Sugihara, Toru

    2014-08-01

    In 2010, the International Society of Geriatric Oncology (SIOG) developed treatment guidelines for men with prostate cancer who are older than 70 years old. In 2013, a new multidisciplinary SIOG working group was formed to update these recommendations. The consensus of the task force is that older men with prostate cancer should be managed according to their individual health status, not according to age. On the basis of a validated rapid health status screening instrument and simple assessment, the task force recommends that patients are classed into three groups for treatment: healthy or fit patients who should have the same treatment options as younger patients; vulnerable patients with reversible impairment who should receive standard treatment after medical intervention; and frail patients with non-reversible impairment who should receive adapted treatment.

  16. [A Critical Condition of Clinical Studies in Japan -- A Battle of Clinical Study Groups].

    PubMed

    Furukawa, Hiroshi

    2016-04-01

    The post-marketing clinical study groups have been losing their activity due to stop of financial support. As the result, clinical study groups cannot achieve any EBM for treatment guidelines. Financial supports should be restarted immediately not to extinguish the post-marketing clinical studies and study groups. PMID:27220798

  17. Proceedings of the 27th International Group for the Psychology of Mathematics Education Conference Held Jointly with the 25th PME-NA Conference (Honolulu, Hawaii, July 13-18, 2003). Volume 1

    ERIC Educational Resources Information Center

    Pateman, Neil A., Ed; Dougherty, Barbara J., Ed.; Zilliox, Joseph T., Ed.

    2003-01-01

    This volume of the 27th International Group for the Psychology of Mathematics Education Conference presents papers from: plenary panels; research forums; working sessions; discussion groups; short oral communications; and poster sessions from the meeting. Plenary lectures included: (1) Studying and Capturing the Complexity of Practice: The Case of…

  18. Unilateral neglect and perceptual parsing: a large-group study.

    PubMed

    Neppi-Mòdona, Marco; Savazzi, Silvia; Ricci, Raffaella; Genero, Rosanna; Berruti, Giuseppina; Pepi, Riccardo

    2002-01-01

    Array-centred and subarray-centred neglect were disambiguated in a group of 116 patients with left neglect by means of a modified version of the Albert test in which the central column of segments was deleted so as to create two separate sets of targets grouped by proximity. The results indicated that neglect was more frequent in array- than subarray-centred coordinates and that, in a minority of cases, neglect co-occurred in both coordinate-systems. The two types of neglect were functionally but not anatomically dissociated. Presence of visual field defects was not prevalent in one type of neglect with respect to the other. These data contribute further evidence to previous single-case and small-group studies by showing that neglect can occur in single or multiple reference frames simultaneously, in agreement with current neuropsychological, neurophysiological and computational concepts of space representation.

  19. Food fortification to reduce vitamin A deficiency: International Vitamin A Consultative Group recommendations.

    PubMed

    Dary, Omar; Mora, Jose O

    2002-09-01

    In developed countries, food fortification has proven an effective and low-cost way to increase the micronutrient supply and reduce the consequences of micronutrient deficiencies. It has been rarely used in the developing world, but general conclusions can be drawn. The biological efficacy, but not the effectiveness, of fortifying oil and hydrogenated oil products as well as cereal flours and meals with vitamin A has been shown. Sugar has been fortified with vitamin A in Central American countries for years, and biological efficacy and program effectiveness are well established. Efficacy of fortifying monosodium glutamate with vitamin A was demonstrated but a program has not been established. Fortification with vitamin A in the developing world should satisfy certain elements for success. a) A potential food matrix (a food regularly consumed, produced by a few centralized factories, without sensorial changes compared with the nonfortified equivalent, and nutrient remains bioavailable and in a sufficient amount) is required. b) Fortified foods should provide at least 15% of the recommended daily intakes for the target group (e.g., individuals consuming the lowest amount of the fortified food). c) Voluntary fortification of processed foods should be regulated to prevent excessive consumption of vitamin A. d) Neighboring countries should harmonize technical standards, facilitate compliance and minimize conflicts over global trade laws. e) A practical monitoring system should be instituted. f) Social marketing activities should be permanent and aimed at industry, government and consumers. g) Food fortification should be combined with other strategies (e.g., supplementation) to reach those not adequately covered by fortification alone. Infants and small children, whose dietary habits differ from those of adults, require special attention. Fortification of food commodities is a very attractive and economic way to prevent and control vitamin A deficiency. Effective food

  20. U.S. GERMAN BILATERAL WORKING GROUP: AN INTERNATIONAL COLLABORATION IN REVITALIZING CONTAMINATED LAND

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) and the German Federal Ministry of Education and Research (BMBF) entered into a Bilateral partnership in 1990 to study each country's efforts in developing and demonstrating innovative tools, techniques and approaches in areas relate...

  1. Biomarkers of sarcopenia in clincal trials recommendations from the international working group on sarcopenia

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the r...

  2. 75 FR 26945 - International Education Programs Service-Fulbright-Hays Group Projects Abroad Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... cultures around the world by supporting: (1) short-term projects abroad that provide pre-service teachers... projects abroad. The first priority helps give pre-service teachers a deeper knowledge of languages and cultures from around the world. The second priority helps increase the study abroad opportunities for...

  3. Personality, Alcohol Use, and Drinking Motives: A Comparison of Independent and Combined Internal Drinking Motives Groups

    ERIC Educational Resources Information Center

    Goldstein, Abby L.; Flett, Gordon L.

    2009-01-01

    It is well-established that coping and enhancement drinking motives predict college student drinking and that personality traits predict drinking motives. Little is known, however, about personality and drinking patterns among individuals who drink for both enhancement and coping reasons. University students in the current study completed…

  4. Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.

    PubMed

    Gottardo, Nicholas G; Hansford, Jordan R; McGlade, Jacqueline P; Alvaro, Frank; Ashley, David M; Bailey, Simon; Baker, David L; Bourdeaut, Franck; Cho, Yoon-Jae; Clay, Moira; Clifford, Steven C; Cohn, Richard J; Cole, Catherine H; Dallas, Peter B; Downie, Peter; Doz, François; Ellison, David W; Endersby, Raelene; Fisher, Paul G; Hassall, Timothy; Heath, John A; Hii, Hilary L; Jones, David T W; Junckerstorff, Reimar; Kellie, Stewart; Kool, Marcel; Kotecha, Rishi S; Lichter, Peter; Laughton, Stephen J; Lee, Sharon; McCowage, Geoff; Northcott, Paul A; Olson, James M; Packer, Roger J; Pfister, Stefan M; Pietsch, Torsten; Pizer, Barry; Pomeroy, Scott L; Remke, Marc; Robinson, Giles W; Rutkowski, Stefan; Schoep, Tobias; Shelat, Anang A; Stewart, Clinton F; Sullivan, Michael; Taylor, Michael D; Wainwright, Brandon; Walwyn, Thomas; Weiss, William A; Williamson, Dan; Gajjar, Amar

    2014-02-01

    Medulloblastoma is curable in approximately 70% of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic and molecular data generated over the last 5-10 years encourages optimism that improved risk stratification and new molecular targets will improve outcomes. It is now clear that medulloblastoma is not a single-disease entity, but instead consists of at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at Bunker Bay, Australia, brought together 50 leading clinicians and scientists. The 2-day agenda included focused sessions on pathology and molecular stratification, genomics and mouse models, high-throughput drug screening, and clinical trial design. The meeting established a global action plan to translate novel biologic insights and drug targeting into treatment regimens to improve outcomes. A consensus was reached in several key areas, with the most important being that a novel classification scheme for medulloblastoma based on the four molecular subgroups, as well as histopathologic features, should be presented for consideration in the upcoming fifth edition of the World Health Organization's classification of tumours of the central nervous system. Three other notable areas of agreement were as follows: (1) to establish a central repository of annotated mouse models that are readily accessible and freely available to the international research community; (2) to institute common eligibility criteria between the Children's Oncology Group and the International Society of Paediatric Oncology Europe and initiate joint or parallel clinical trials; (3) to share preliminary high-throughput screening data across discovery labs to hasten the development of novel therapeutics

  5. Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study

    PubMed Central

    Moskal, Aurelie; Pisa, Pedro T.; Ferrari, Pietro; Byrnes, Graham; Freisling, Heinz; Boutron-Ruault, Marie-Christine; Cadeau, Claire; Nailler, Laura; Wendt, Andrea; Kühn, Tilman; Boeing, Heiner; Buijsse, Brian; Tjønneland, Anne; Halkjær, Jytte; Dahm, Christina C.; Chiuve, Stephanie E.; Quirós, Jose R.; Buckland, Genevieve; Molina-Montes, Esther; Amiano, Pilar; Huerta Castaño, José M.; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Lentjes, Marleen A.; Key, Timothy J.; Romaguera, Dora; Vergnaud, Anne-Claire; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; de Magistris, Maria Santucci; Bueno-de-Mesquita, H. Bas; Ocké, Marga C.; Beulens, Joline W. J.; Ericson, Ulrika; Drake, Isabel; Nilsson, Lena M.; Winkvist, Anna; Weiderpass, Elisabete; Hjartåker, Anette; Riboli, Elio; Slimani, Nadia

    2014-01-01

    Background Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. Methodology/Principal Findings We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. Conclusion/Significance The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs

  6. Geothermal development of the Madison group aquifer: a case study

    SciTech Connect

    Martinez, J.A.

    1981-01-01

    A geothermal well has been drilled at the St. Mary's Hospital in Pierre, South Dakota. The well is 2176 feet deep and artesian flows 375 gpm at 106/sup 0/F. The well is producing fluids from the Mississippian Madison Group, a sequence of carbonate rocks deposited over several western states. The project was funded to demonstrate the goethermal potential of this widespread aquifer. This case study describes the development of the project through geology, drilling, stimulation, and testing.

  7. Ab-Initio Study of the Group 2 Hydride Anions

    NASA Astrophysics Data System (ADS)

    Harris, Joe P.; Wright, Timothy G.; Manship, Daniel R.

    2013-06-01

    The beryllium hydride (BeH)- dimer has recently been shown to be surprisingly strongly bound, with an electronic structure which is highly dependent on internuclear separation. At the equilibrium distance, the negative charge is to be found on the beryllium atom, despite the higher electronegativity of the hydrogen. The current study expands this investigation to the other Group 2 hydrides, and attempts to explain these effects. M. Verdicchio, G. L. Bendazzoli, S. Evangelisti, T. Leininger J. Phys. Chem. A, 117, 192, (2013)

  8. International Comparative Studies in Education: Descriptions of Selected Large-Scale Assessments and Case Studies.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC. Commission on Behavioral and Social Sciences and Education.

    Since its inception in 1988, the Board on International Comparative Studies in Education (BICSE) has monitored U.S. participation in those cross national comparative studies in education that are funded by its sponsors, the National Science Foundation and the National Center for Education Statistics. This set of international study descriptions…

  9. A microwave study of hydrogen-transfer-triggered methyl-group rotation in 5-methyltropolone.

    PubMed

    Ilyushin, Vadim V; Cloessner, Emily A; Chou, Yung-Ching; Picraux, Laura B; Hougen, Jon T; Lavrich, Richard

    2010-11-14

    We present here the first experimental and theoretical study of the microwave spectrum of 5-methyltropolone, which can be visualized as a seven-membered "aromatic" carbon ring with a five-membered hydrogen-bonded cyclic structure at the top and a methyl group at the bottom. The molecule is known from earlier studies in the literature to exhibit two large-amplitude motions, an intramolecular hydrogen transfer and a methyl torsion. The former motion is particularly interesting because transfer of the hydrogen atom from the hydroxyl to the carbonyl group induces a tautomerization in the molecule, which then triggers a 60° internal rotation of the methyl group. Measurements were carried out by Fourier-transform microwave spectroscopy in the 8-24 GHz frequency range. Theoretical analysis was carried out using a tunneling-rotational Hamiltonian based on a G(12)(m) extended-group-theory formalism. Our global fit of 1015 transitions to 20 molecular parameters gave a root-mean-square deviation of 1.5 kHz. The tunneling splitting of the two J=0 levels arising from a hypothetical pure hydrogen-transfer motion is calculated to be 1310 MHz. The tunneling splitting of the two J=0 levels arising from a hypothetical pure methyl top internal-rotation motion is calculated to be 885 MHz. We have also carried out ab initio calculations, which support the structural parameters determined from our spectroscopic analysis and give estimates of the barriers to the two large-amplitude motions.

  10. Suicide Mortality Across Broad Occupational Groups in Greece: A Descriptive Study

    PubMed Central

    Alexopoulos, Evangelos C.; Kavalidou, Katerina; Messolora, Fani

    2015-01-01

    Background Several studies have investigated the relationship between specific occupations and suicide mortality, as suicide rates differ by profession. The aim of this study was to investigate suicide mortality ratios across broad occupational groups in Greece for both sexes in the period 2000–2009. Methods Data of suicide deaths were retrieved from the Hellenic Statistical Authority and comparative mortality ratios were calculated. Occupational classification was based on the International Classification of Occupations (ISCO-88) and the coding for Intentional self-harm (X60–X84) was based on the international classification of diseases (ICD-10). Results Male dominant occupations, mainly armed forces, skilled farmers and elementary workers, and female high-skilled occupations were seen as high risk groups for suicide in a period of 10 years. The age-productive group of 30–39 years in Greek male elementary workers and the 50–59 age-productive group of Greek professional women proved to have the most elevated number of suicide deaths. Conclusion Further research is needed into the work-related stressors of occupations with high suicide mortality risk and focused suicide prevention strategies should be applied within vulnerable working age populations. PMID:27014484

  11. Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) Group

    PubMed Central

    2012-01-01

    Introduction Renal dysfunction is a common complication in patients with end-stage cirrhosis. Since the original publication of the definition and diagnostic criteria for the hepatorenal syndrome (HRS), there have been major advances in our understanding of its pathogenesis. The prognosis of patients with cirrhosis who develop HRS remains poor, with a median survival without liver transplantation of less than six months. However, a number of pharmacological and other therapeutic strategies have now become available which offer the ability to prevent or treat renal dysfunction more effectively in this setting. Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies. Methods We undertook a systematic review of the literature using Medline, PubMed and Web of Science, data provided by the Scientific Registry of Transplant Recipients and the bibliographies of key reviews. We determined a list of key questions and convened a two-day consensus conference to develop summary statements via a series of alternating breakout and plenary sessions. In these sessions, we identified supporting evidence and generated recommendations and/or directions for future research. Results Of the 30 questions considered, we found inadequate evidence for the majority of questions and our recommendations were mainly based on expert opinion. There was insufficient evidence to grade three questions, but we were able to develop a consensus definition for acute kidney injury in patients with cirrhosis and provide consensus recommendations for future investigations to address key areas of uncertainty. Conclusions Despite a paucity of sufficiently powered prospectively randomized trials, we were able to establish an evidence-based appraisal of this field and develop a set of consensus recommendations to standardize care and direct further research for patients with cirrhosis and renal dysfunction. PMID:22322077

  12. Pressurized-water reactor internals aging degradation study. Phase 1

    SciTech Connect

    Luk, K.H.

    1993-09-01

    This report documents the results of a Phase I study on the effects of aging degradations on pr internals. Primary stressers for internals an generated by the primary coolant flow in the they include unsteady hydrodynamic forces and pump-generated pressure pulsations. Other stressors are applied loads, manufacturing processes, impurities in the coolant and exposures to fast neutron fluxes. A survey of reported aging-related failure information indicates that fatigue, stress corrosion cracking (SCC) and mechanical wear are the three major aging-related degradation mechanisms for PWR internals. Significant reported failures include thermal shield flow-induced vibration problems, SCC in guide tube support pins and core support structure bolts, fatigue-induced core baffle water-jet impingement problems and excess wear in flux thimbles. Many of the reported problems have been resolved by accepted engineering practices. Uncertainties remain in the assessment of long-term neutron irradiation effects and environmental factors in high-cycle fatigue failures. Reactor internals are examined by visual inspections and the technique is access limited. Improved inspection methods, especially one with an early failure detection capability, can enhance the safety and efficiency of reactor operations.

  13. Status of the International Design Study of the Neutrino Factory

    SciTech Connect

    Long, Kenneth

    2010-03-30

    The International Design Study for the Neutrino Factory (the IDS-NF) has been established by the Neutrino Factory community to deliver the Reference Design Report (RDR) for the facility by 2012. The baseline design for the facility, developed from that defined in the International Scoping Study of a future Neutrino Factory and super-beam facility (the ISS), will provide 10{sup 21} muon decays per year from 25 GeV stored muon beams. The facility will serve two neutrino detectors; one situated at source-detector distance of between 3000-5000 km, the second at 7000-8000 km. The baseline design for the facility will be described and the status of the IDS-NF effort will be summarised.

  14. Study on the Internship Programs for International Students

    NASA Astrophysics Data System (ADS)

    Yamamoto, Izumi; Iwatsu, Fumio

    Recently, the number of international students who have an experience of internship as employment experience has been increasing. In general, internship is a system through which students gain a work experience relating to his/her major field and future career, while at university. Many Japanese leading industries are situated in this Chubu area. Therefore, we have tried to facilitate an internship as a part of the curriculum from 2005. Here we report the progress of our internship programs and try to study the possibility of its future. Through this study, we can say that an internship would be a good opportunity for both international students and Japanese companies to understand each other. On the other hand, it is hard to bring the system to match students and companies, form both side of financial base and human resource. Therefore, to bring up good talent becomes to good connection with the industrial world.

  15. Adolescent girls' views on cosmetic surgery: A focus group study.

    PubMed

    Ashikali, Eleni-Marina; Dittmar, Helga; Ayers, Susan

    2016-01-01

    This study examined adolescent girls' views of cosmetic surgery. Seven focus groups were run with girls aged 15-18 years (N = 27). Participants read case studies of women having cosmetic surgery, followed by discussion and exploration of their views. Thematic analysis identified four themes: (1) dissatisfaction with appearance, (2) acceptability of cosmetic surgery, (3) feelings about undergoing cosmetic surgery and (4) cosmetic surgery in the media. Results suggest the acceptability of cosmetic surgery varies according to the reasons for having it and that the media play an important role by normalising surgery and under-representing the risks associated with it.

  16. Bayesian model reduction and empirical Bayes for group (DCM) studies.

    PubMed

    Friston, Karl J; Litvak, Vladimir; Oswal, Ashwini; Razi, Adeel; Stephan, Klaas E; van Wijk, Bernadette C M; Ziegler, Gabriel; Zeidman, Peter

    2016-03-01

    This technical note describes some Bayesian procedures for the analysis of group studies that use nonlinear models at the first (within-subject) level - e.g., dynamic causal models - and linear models at subsequent (between-subject) levels. Its focus is on using Bayesian model reduction to finesse the inversion of multiple models of a single dataset or a single (hierarchical or empirical Bayes) model of multiple datasets. These applications of Bayesian model reduction allow one to consider parametric random effects and make inferences about group effects very efficiently (in a few seconds). We provide the relatively straightforward theoretical background to these procedures and illustrate their application using a worked example. This example uses a simulated mismatch negativity study of schizophrenia. We illustrate the robustness of Bayesian model reduction to violations of the (commonly used) Laplace assumption in dynamic causal modelling and show how its recursive application can facilitate both classical and Bayesian inference about group differences. Finally, we consider the application of these empirical Bayesian procedures to classification and prediction.

  17. Bayesian model reduction and empirical Bayes for group (DCM) studies

    PubMed Central

    Friston, Karl J.; Litvak, Vladimir; Oswal, Ashwini; Razi, Adeel; Stephan, Klaas E.; van Wijk, Bernadette C.M.; Ziegler, Gabriel; Zeidman, Peter

    2016-01-01

    This technical note describes some Bayesian procedures for the analysis of group studies that use nonlinear models at the first (within-subject) level – e.g., dynamic causal models – and linear models at subsequent (between-subject) levels. Its focus is on using Bayesian model reduction to finesse the inversion of multiple models of a single dataset or a single (hierarchical or empirical Bayes) model of multiple datasets. These applications of Bayesian model reduction allow one to consider parametric random effects and make inferences about group effects very efficiently (in a few seconds). We provide the relatively straightforward theoretical background to these procedures and illustrate their application using a worked example. This example uses a simulated mismatch negativity study of schizophrenia. We illustrate the robustness of Bayesian model reduction to violations of the (commonly used) Laplace assumption in dynamic causal modelling and show how its recursive application can facilitate both classical and Bayesian inference about group differences. Finally, we consider the application of these empirical Bayesian procedures to classification and prediction. PMID:26569570

  18. First on-line survey of an international multidisciplinary working group (MightyMedic) on current practice in diagnosis, therapy and follow-up of dyslipidemias.

    PubMed

    Stefanutti, C; D'Alessandri, G; Petta, A; Harada-Shiba, M; Julius, U; Soran, H; Moriarty, P M; Romeo, S; Drogari, E; Jaeger, B R

    2015-05-01

    The MightyMedic (Multidisciplinary International Group for Hemapheresis TherapY and MEtabolic DIsturbances Contrast) Working Group has been founded in 2013. The leading idea was to establish an international network of interdisciplinary nature aimed at working to cross national borders research projects, clinical trials, educational initiatives (meetings, workshops, summer schools) in the field of metabolic diseases, namely hyperlipidemias, and diabetes, preventive cardiology, and atherosclerosis. Therapeutic apheresis, its indications and techniques, is a parallel field of investigation. The first on-line survey of the Group has been completed in the first half of 2014. The survey included # 24 Centers in Italy, Germany, Greece, UK, Sweden, Japan and USA. Relevant data have been collected on current practice in diagnosis, therapy and follow-up of dyslipidemias. 240 subjects with hyperlipidemia and treated with lipoprotein apheresis have been reported in the survey, but a large percentage of patients (35%) who could benefit from this therapeutic option are still treated by conventional drug approach. Genetic molecular diagnosis is performed in only 33% of patients while Lipoprotein(a) (Lp(a)) is included in cardiovascular disease risk assessment in 71% of participating Centers. New detailed investigations and prospective multicenter studies are needed to evaluate changes induced by the impact of updated indications and strategies, as well as new treatment options, targeting standardization of therapeutic and diagnostic approaches.

  19. Erythromycin resistance genes in group A streptococci in Finland. The Finnish Study Group for Antimicrobial Resistance.

    PubMed

    Kataja, J; Huovinen, P; Skurnik, M; Seppälä, H

    1999-01-01

    Streptococcus pyogenes isolates (group A streptococcus) of different erythromycin resistance phenotypes were collected from all over Finland in 1994 and 1995 and studied; they were evaluated for their susceptibilities to 14 antimicrobial agents (396 isolates) and the presence of different erythromycin resistance genes (45 isolates). The erythromycin-resistant isolates with the macrolide-resistant but lincosamide- and streptogramin B-susceptible phenotype (M phenotype) were further studied for their plasmid contents and the transferability of resistance genes. Resistance to antimicrobial agents other than macrolides, clindamycin, tetracycline, and chloramphenicol was not found. When compared to our previous study performed in 1990, the rate of resistance to tetracycline increased from 10 to 93% among isolates with the inducible resistance (IR) phenotype of macrolide, lincosamide, and streptogramin B (MLSB) resistance. Tetracycline resistance was also found among 75% of the MLSB-resistant isolates with the constitutive resistance (CR) phenotype. Resistance to chloramphenicol was found for the first time in S. pyogenes in Finland; 3% of the isolates with the IR phenotype were resistant. All the chloramphenicol-resistant isolates were also resistant to tetracycline. Detection of erythromycin resistance genes by PCR indicated that, with the exception of one isolate with the CR phenotype, all M-phenotype isolates had the macrolide efflux (mefA) gene and all the MLSB-resistant isolates had the erythromycin resistance methylase (ermTR) gene; the isolate with the CR phenotype contained the ermB gene. No plasmid DNA could be isolated from the M-phenotype isolates, but the mefA gene was transferred by conjugation.

  20. Faculty Study Groups: Solving "Good Problems" through Study, Reflection, and Collaboration.

    ERIC Educational Resources Information Center

    Wildman, Terry M.; Hable, Margaret P.; Preston, Marlene M.; Magliaro, Susan G.

    2000-01-01

    Describes the development, implementation, and assessment of a faculty study group program at Virginia Polytechnic Institute and State University. The study group was designed to foster teaching as a reflective, collaborative activity and encourage interaction of faculty of different disciplines, age groups, ranks, and teaching experience. (DB)

  1. Loss of glenohumeral internal rotation in little league pitchers: a biomechanical study.

    PubMed

    Nakamizo, Hiroyuki; Nakamura, Yasuo; Nobuhara, Katsuya; Yamamoto, Tetsuji

    2008-01-01

    Glenohumeral internal rotation deficit (GIRD) is a significant shoulder problem for throwing athletes. GIRD, however, has not been reported in little league pitchers. The purpose of this study was to investigate GIRD in little leaguers. The range of motion of both shoulders was measured in 25 male little league pitchers. All pitchers underwent motion analyses of their pitching to evaluate shoulder kinematics. GIRD was found in 10 of the 25 pitchers. External rotation in the dominant arm in the GIRD group was not significantly different compared to the contralateral or dominant arm in the non-GIRD group. This biomechanical study showed that the GIRD group had increased external rotation while throwing compared to the non-GIRD group. These findings indicate that GIRD can occur prior to development of the increased external rotation in the dominant arm seen in adult throwers.

  2. The UNESCO-IHP Working Group on Land Subsidence: Four Decades of International Contributions to Hydrogeological Related Subsidence Research and Knowledge Exchange

    NASA Astrophysics Data System (ADS)

    Galloway, D. L.; Carreon-Freyre, D.; Teatini, P.; Ye, S.

    2015-12-01

    Subsidence is globally prevalent and because much of it is related to hydrological processes affected by human development of local land and water resources, "Land Subsidence" was included in the UNESCO programme of the International Hydrological Decade (IHD), 1965-1974 and an ad hoc working group on land subsidence was formed. In 1975 subsidence was retained under the framework of the UNESCO IHP (subproject 8.4: "Investigation of Land Subsidence due to Groundwater Exploitation"), and UNESCO IHP formerly codified the Working Group on Land Subsidence (WGLS). In 1984 the WGLS produced a comprehensive guidebook to serve scientists and engineers, confronting land subsidence problems, particularly in developing countries (http://unesdoc.unesco.org/$other/unesdoc/pdf/065167eo.pdf). During the IHD, UNESCO IHP convened the 1st International Symposium on Land Subsidence in 1969 in Tokyo, Japan. In collaboration with UNESCO IHP, IAHS, and other scientific organizations, the WGLS has convened eight more International Symposia on Land Subsidence in different countries in Asia, Europe and North America. The 9 published symposia proceedings constitute an important source of global subsidence research and case studies during the past 45 years, covering both anthropogenic and natural subsidence processes. Currently, the WGLS comprising 20 subsidence experts from 9 countries promotes and facilitates the international exchange of information regarding the design, implementation and evaluation of risk assessments and mitigation measures, the definition of water and land resource-management strategies that support sustainable development in areas vulnerable to subsidence (http://landsubsidence-unesco.org), and the assessment of related geological risks such as earth fissuring and fault activation (www.igcp641.org). The WGLS has become an important global leader in promoting subsidence awareness, scientific research and its application to subsidence monitoring, analysis and management.

  3. Do Herbal Formulas Influence the International Normalized Ratio of Patients Taking Warfarin? A Retrospective Study

    PubMed Central

    Lu, Hsu-Yuan; Cho, Seung-Yeon; Park, Seong-Uk; Jung, Woo-Sang; Moon, Sang-Kwan; Park, Jung-Mi; Ko, Chang-Nam

    2015-01-01

    Warfarin is a common anticoagulant agent for cardiovascular diseases, and it is known to interact with several foods and drugs. Several studies report an interaction between warfarin and herbal medicines; however, the influence of herbal medicines on the international normalized ratio (INR) is still controversial. We investigated the influence of herbal formulas on INR of patients taking warfarin. We searched electronic medical records of inpatients for INR results. Then, we compared the changes in INR and any adverse events between the group taking herbal formulas and warfarin (herbal group) and another group taking warfarin only (nonherbal group). Eighty-six patients were included; 45 patients were assigned to the herbal group and 41 patients to the nonherbal group. The herbal group had taken the same dose of warfarin for a longer period. The nonherbal group had a slightly higher mean INR value than the herbal group. The ratio of INR less than 2 and greater than 3, the ratio of INR that increased or decreased by one or more compared to the initial INR, and the ratio of adverse events were not significantly different between the two groups. It is suggested that use of herbal formulas may not influence INR value. PMID:25861354

  4. [Pediatric pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

    PubMed

    Párniczky, Andrea; Czakó, László; Dubravcsik, Zsolt; Farkas, Gyula; Hegyi, Péter; Hritz, István; Kelemen, Dezső; Morvay, Zita; Oláh, Attila; Pap, Ákos; Sahin-Tóth, Miklós; Szabó, Flóra; Szentkereszti, Zsolt; Szmola, Richárd; Takács, Tamás; Tiszlavicz, László; Veres, Gábor; Szücs, Ákos; Lásztity, Natália

    2015-02-22

    Pediatric pancreatitis is a rare disease with variable etiology. In the past 10-15 years the incidence of pediatric pancreatitis has been increased. The management of pediatric pancreatitis requires up-to-date and evidence based management guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidences. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and complemented and/or modified the international guidelines if it was necessary. In 8 clinical topics (diagnosis; etiology; prognosis; imaging; therapy; biliary tract management; complications; chronic pancreatitis) 50 relevant questions were defined. Evidence was classified according to the UpToDate(®) grading system. The draft of the guidelines was presented and discussed at the consensus meeting on September 12, 2014. All clinical statements were accepted with total (more than 95%) agreement. The present Hungarian Pancreatic Study Group guideline is the first evidence based pediatric pancreatitis guideline in Hungary. The present guideline is the first evidence-based pancreatic cancer guideline in Hungary that provides a solid ground for teaching purposes, offers quick reference for daily patient care in pediatric pancreatitis and guides financing options. The authors strongly believe that these guidelines will become a standard reference for pancreatic cancer treatment in Hungary.

  5. Decentralized energy studies: compendium of international studies and research

    SciTech Connect

    Wallace, C.

    1980-03-01

    The purpose of the compendium is to provide information about research activities in decentralized energy systems to researchers, government officials, and interested citizens. The compendium lists and briefly describes a number of studies in other industrialized nations that involve decentralized energy systems. A contact person is given for each of the activities listed so that interested readers can obtain more information.

  6. Site-specific labeling of RNA at internal ribose hydroxyl groups: terbium-assisted deoxyribozymes at work.

    PubMed

    Büttner, Lea; Javadi-Zarnaghi, Fatemeh; Höbartner, Claudia

    2014-06-01

    A general and efficient single-step method was established for site-specific post-transcriptional labeling of RNA. Using Tb(3+) as accelerating cofactor for deoxyribozymes, various labeled guanosines were site-specifically attached to 2'-OH groups of internal adenosines in in vitro transcribed RNA. The DNA-catalyzed 2',5'-phosphodiester bond formation proceeded efficiently with fluorescent, spin-labeled, biotinylated, or cross-linker-modified guanosine triphosphates. The sequence context of the labeling site was systematically analyzed by mutating the nucleotides flanking the targeted adenosine. Labeling of adenosines in a purine-rich environment showed the fastest reactions and highest yields. Overall, practically useful yields >70% were obtained for 13 out of 16 possible nucleotide (nt) combinations. Using this approach, we demonstrate preparative labeling under mild conditions for up to ~160-nt-long RNAs, including spliceosomal U6 small nuclear RNA and a cyclic-di-AMP binding riboswitch RNA.

  7. Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group

    PubMed Central

    Avet-Loiseau, Hervé; Lonial, Sagar; Usmani, Saad; Siegel, David; Anderson, Kenneth C.; Chng, Wee-Joo; Moreau, Philippe; Attal, Michel; Kyle, Robert A.; Caers, Jo; Hillengass, Jens; San Miguel, Jesús; van de Donk, Niels W. C. J.; Einsele, Hermann; Bladé, Joan; Durie, Brian G. M.; Goldschmidt, Hartmut; Mateos, María-Victoria; Palumbo, Antonio; Orlowski, Robert

    2016-01-01

    The International Myeloma Working Group consensus updates the definition for high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities such as t(4;14), del(17/17p), t(14;16), t(14;20), nonhyperdiploidy, and gain(1q) were identified that confer poor prognosis. The prognosis of patients showing these abnormalities may vary with the choice of therapy. Treatment strategies have shown promise for HR cytogenetic diseases, such as proteasome inhibition in combination with lenalidomide/pomalidomide, double autologous stem cell transplant plus bortezomib, or combination of immunotherapy with lenalidomide or pomalidomide. Careful analysis of cytogenetic subgroups in trials comparing different treatments remains an important goal. Cross-trial comparisons may provide insight into the effect of new drugs in patients with cytogenetic abnormalities. However, to achieve this, consensus on definitions of analytical techniques, proportion of abnormal cells, and treatment regimens is needed. Based on data available today, bortezomib and carfilzomib treatment appear to improve complete response, progression-free survival, and overall survival in t(4;14) and del(17/17p), whereas lenalidomide may be associated with improved progression-free survival in t(4;14) and del(17/17p). Patients with multiple adverse cytogenetic abnormalities do not benefit from these agents. FISH data are implemented in the revised International Staging System for risk stratification. PMID:27002115

  8. One RNA plays three roles to provide catalytic activity to a group I intron lacking an endogenous internal guide sequence.

    PubMed

    Vaidya, Nilesh; Lehman, Niles

    2009-07-01

    Catalytic RNA molecules possess simultaneously a genotype and a phenotype. However, a single RNA genotype has the potential to adopt two or perhaps more distinct phenotypes as a result of differential folding and/or catalytic activity. Such multifunctionality would be particularly significant if the phenotypes were functionally inter-related in a common biochemical pathway. Here, this phenomenon is demonstrated by the ability of the Azoarcus group I ribozyme to function when its canonical internal guide sequence (GUG) has been removed from the 5' end of the molecule, and added back exogenously in trans. The presence of GUG triplets in non-covalent fragments of the ribozyme allow trans-splicing to occur in both a reverse splicing assay and a covalent self-assembly assay in which the internal guide sequence (IGS)-less ribozyme can put itself together from two of its component pieces. Analysis of these reactions indicates that a single RNA fragment can perform up to three distinct roles in a reaction: behaving as a portion of a catalyst, behaving as a substrate, and providing an exogenous IGS. This property of RNA to be multifunctional in a single reaction pathway bolsters the probability that a system of self-replicating molecules could have existed in an RNA world during the origins of life on the Earth. PMID:19406926

  9. NREL Case Study Leads to International Partnership (Fact Sheet)

    SciTech Connect

    Not Available

    2013-12-01

    In 2012, NREL analysts produced a case study, "Integrating Variable Renewable Energy in Electric Power Markets: Best Practices from International Experience," which drew upon dozens of interviews with international experts involved in crafting effective policies and markets. The report proposed a cross-cutting initiative to transform the world's power systems by implementing two complementary strategies: the large‐scale deployment of renewable energy, and a combination of comprehensive energy efficiency and smarter grids. This recommendation led to the launch of the 21st Century Power Partnership in April 2012, and its membership has since grown to include Denmark, Finland, Germany, India, Mexico, Spain, and the United States. NREL, together with its affiliated Joint Institute for Strategic Energy Analysis, are the operating agents.

  10. Internal configuration and electric potential in planar negatively charged lipid head group region in contact with ionic solution.

    PubMed

    Lebar, Alenka Maček; Velikonja, Aljaž; Kramar, Peter; Iglič, Aleš

    2016-10-01

    The lipid bilayer composed of negatively charged lipid 1-palmitoyl-3-oleoyl-sn-glycero-3-phosphatidylserine (POPS) in contact with an aqueous solution of monovalent salt ions was studied theoretically by using the mean-field modified Langevin-Poisson-Boltzmann (MLPB) model. The MLPB results were tested by using molecular dynamic (MD) simulations. In the MLPB model the charge distribution of POPS head groups is theoretically described by the negatively charged surface which accounts for negatively charged phosphate groups, while the positively charged amino groups and negatively charged carboxylate groups are assumed to be fixed on the rod-like structures with rotational degree of freedom. The spatial variation of relative permittivity, which is not considered in the well-known Gouy-Chapman (GC) model or in MD simulations, is thoroughly derived within a strict statistical mechanical approach. Therefore, the spatial dependence and magnitude of electric potential within the lipid head group region and its close vicinity are considerably different in the MLPB model from the GC model. The influence of the bulk salt concentration and temperature on the number density profiles of counter-ions and co-ions in the lipid head group region and aqueous solution along with the probability density function for the lipid head group orientation angle was compared and found to be in qualitative agreement in the MLPB and MD models. PMID:27209203

  11. A proportional mortality study of a group of newspaper workers

    PubMed Central

    Greenberg, M.

    1972-01-01

    Greenberg, M. (1972).Brit. J. industr. Med.,29, 15-20. A proportional mortality study of a group of newspaper workers. In investigating an anecdotal report of a high incidence of bladder cancer at a London newspaper printing factory, death certificates for 670 workers relating to the years 1954-66 were studied. While an increased incidence of carcinoma of the urinary organs could not be demonstrated, the total of all malignancies was greater than predicted and carcinoma of the bronchus accounted for much of the excess. Only death by suicide occurred to excess among causes of death other than malignancy. The smoking habits of subjects are not known but if tobacco habit contributed to bronchial carcinoma it had no observable effect on the incidence of chronic bronchitis and ischaemic heart disease in early middle age. It is concluded that a prospective study would be required if occupation is to be implicated as a hazard. PMID:5062168

  12. Structural studies on an internal loop from a hairpin ribozyme

    SciTech Connect

    Cai, Z.; SantaLucia, J. Jr.; Tinoco, I. Jr.

    1994-12-01

    Ribozymes, RNA enzymes, catalyze site-specific RNA cleavage and ligation reactions. We are studying the three-dimensional structure of a hairpin ribozyme derived from the minus strand of tobacco ring spot virus satellite RNA ((-)sTRSV), which has been engineering to specifically cleave the HIV-1 RNA. The minimum structure for the catalytic reaction involves a 50-nucleotide ribozyme and a 14-nucleotide substrate. The proposed secondary structure of the ribozyme-substrate complex consists of four short helices separated by two internal loops. The relatively large size (64-nucleotide) of the ribozyme-substrate complex presents formidable problems in solving the structure using NMR. Therefore we are studying smaller structural subunits of the complex. We are determining the high resolution structure of the symmetric internal loop involving the cleavage site and the flanking helices. One strand of the internal loop was selectively {sup 13}C-labeled at C8 of each purine and C6 of each pyrimidine. By using {sup 13}C-edited two-dimensional NMR, the proton NOESY spectrum was greatly simplified. This allowed unambiguous sequential proton resonance assignments along each strand. Three-dimensional {sup 1}-{sup 13}C HMQC-NOESY was used to further facilitate resonance assignments. We are also enzymatically synthesizing the entire 50-nucleotide ribozyme and will combine it with the {sup 13}C-labeled substrate. Through comparison of the NOE connectivities of the labeled nucleotides from the internal loop alone with those from the entire complex, the differences between the two structures can be elucidated.

  13. EXPERIENCES OF GAMMA HYDROXYBUTYRATE (GHB) INGESTION: A FOCUS GROUP STUDY

    PubMed Central

    Barker, Judith C.; Harris, Shana L.; Dyer, Jo E.

    2008-01-01

    GHB (gamma hydroxybutyrate) is a significant new drug of abuse added to the United States Controlled Substance Act in 2000. The majority of the published literature on GHB consists of clinical case reports, mainly from emergency departments, and a collection of laboratory-based studies, focused mainly on anesthesia. While comments about the various experiences and behaviors of human users are often included in such studies or reports, these aspects of GHB are only just beginning to be systematically investigated or detailed. Reported here are data from a qualitative study using focus group methods on the consumption habits, experiences, and beliefs of GHB users. A total of 51 people, 30 men and 21 women, mean age of 31.1±7.6 years (range 18 – 52 years), who report having used GHB for an average of 4.3±2.5 years (range 1–11 years), were interviewed in 10 separate groups held in 2004. This paper discusses broadly the general experience of the GHB ‘high,’ major perceived benefits including sexual responses to the drug, perceived risks and dangers of ingestion, co-ingestion, and various contexts of use. The paper concludes with a discussion of the implications drawn from this information for clinicians treating patients who use GHB. PMID:17703706

  14. [Study on Characteristics of Terahertz Spectra of Organic Functional Groups].

    PubMed

    Ma, Chun-qian; Xu, Xiang-dong; Zou, Rui-jiao; Liu, Yi-ke; He, Qiong; Jiang, Ya-dong; Huang, Rui; Wen, Yue-jiang; Sun, Zi-qiang

    2015-04-01

    Fourier transform infrared (FTIR) was exploited to measure terahertz (THz) spectra in the wave number range of 30-300 cm(-1) for saturated straight chain organic molecules at room temperature. The results reveal that different organic functional groups exhibit different THz spectral characteristics. The absorption peaks of vibration modes of organic crystal lattice locate in high frequency range of THz, while those of vibration modes of intermolecular hydrogen (H) bonds appear in low frequency range of THz. Moreover, a typical absorption peak of intermolecular H bonds caused by saturated straight-chain monohydric alcohol hydroxyl functional groups locates at 57 cm(-1), while a characteristic absorption peak of intermolecular hydrogen bonds caused by triacontanoic acid carboxyl functional groups appears at 74 cm(-1). The intermolecular H bonds not only result in that the THz absorbing abilities of triacontanol and triacontanoic acid are significantly stronger than that of triacontane, but also cause regular red-shift and blue-shift of the THz absorption peaks of triacontanoic acid, as compared with those of triacontanol. In addition, density functional theory (DFT) B3LYP/6-311G(d,p) basis set was employed to simulate the THz spectra of saturated straight-chain alkane, alkanol and acid, respectively. The simulation results indicate that for the organic molecules with stronger intermolecular H bonds, lower consistent degree of the THz spectrum simulated from monomer molecule with the THz spectrum experimentally measured will occur. Moreover, the simulation results of dimer structures agree well with the measured spectra as compared to those simulated from monomer molecule structures. The results presented in this work are of great significance not only to the study of the THz spectral characteristics of other organic functional groups, but also to the clarification of the vibration modes of organic molecules. Particularly, our results are also helpful for clarifying

  15. Density matrix renormalization group numerical study of the kagome antiferromagnet.

    PubMed

    Jiang, H C; Weng, Z Y; Sheng, D N

    2008-09-12

    We numerically study the spin-1/2 antiferromagnetic Heisenberg model on the kagome lattice using the density-matrix renormalization group method. We find that the ground state is a magnetically disordered spin liquid, characterized by an exponential decay of spin-spin correlation function in real space and a magnetic structure factor showing system-size independent peaks at commensurate magnetic wave vectors. We obtain a spin triplet excitation gap DeltaE(S=1)=0.055+/-0.005 by extrapolation based on the large size results, and confirm the presence of gapless singlet excitations. The physical nature of such an exotic spin liquid is also discussed.

  16. Workers' perception of chemical risks: a focus group study.

    PubMed

    Hambach, Ramona; Mairiaux, Philippe; François, Guido; Braeckman, Lutgart; Balsat, Alain; Van Hal, Guido; Vandoorne, Chantal; Van Royen, Paul; van Sprundel, Marc

    2011-02-01

    Workers' perceptions with respect to health and safety at work are rarely taken into account when considering the development of prevention programs. The aim of this study was to explore workers' perceptions of chemical risks at the workplace, in order to investigate the prerequisites for a workplace health program. A qualitative study was conducted involving seven focus groups of 5-10 participants (blue-collar workers) each. All groups were homogeneous in terms of sex, work status, language, and company membership. Results showed that several factors have an important influence on workers' perception of chemical risks. Workers assess risks by means of both sensory and empirical diagnosis and are concerned about the long-term health consequences. They perceive the threat of chemical risks as high. Despite this, they are resigned to accepting the risks. Existing formal sources of information are rarely consulted because they are judged to be difficult to understand and not user friendly. Instead, workers tend to obtain information from informal sources. Communication problems with and lack of trust in prevention advisers and hierarchy are frequently mentioned. Workers feel that their specific knowledge of their working conditions and their proposals for practical, cost-effective solutions to improve health and safety at the workplace are insufficiently taken into account. The use of focus groups yielded a useful insight into workers' perceptions of chemical risks. Our findings suggest that training programs for prevention advisers should include topics such as understanding of workers' perceptions, usefulness of a participatory approach, and communication and education skills. PMID:20846168

  17. Position Paper on International Studies Program at C. S. Mott Community College.

    ERIC Educational Resources Information Center

    Joseph, Wise B.

    This descriptive report outlines the history and operation of the International Studies Program at Charles Stewart Mott Community College (MCC). First, introductory material discusses the growing importance of international studies in the nation's community colleges. Next, the need for an international studies and international trade program at…

  18. Needs Assessment for the Establishment of a Masters of Arts Program in International Studies with a Concentration in International Security and a Specialization in International Terrorism

    ERIC Educational Resources Information Center

    Gray, David H.

    2008-01-01

    Since the attacks of September 11, national and international security has been driven to the center stage of our present-day society, thus becoming a primary concern and focus in the United States. The purpose of this study was to conduct an instructional needs assessment for the establishment of a Masters of Arts program in International Studies…

  19. Enhancement of Apoptosis by Titanium Alloy Internal Fixations during Microwave Treatments for Fractures: An Animal Study

    PubMed Central

    Zhang, Lina; Ye, Dongmei; Feng, Xianxuan; Fu, Tengfei; Bai, Yuehong

    2015-01-01

    Objective Microwaves are used in one method of physical therapy and can increase muscle tissue temperature which is useful for improving muscle, tendon and bone injuries. In the study, we sought to determine whether titanium alloy internal fixations influence apoptosis in tissues subjected to microwave treatments at 2,450 MHz and 40 W during the healing of fractures because this issue is not yet fully understood. Methods In this study, titanium alloy internal fixations were used to treat 3.0-mm transverse osteotomies in the middle of New Zealand rabbits’ femurs. After the operation, 30-day microwave treatments were applied to the 3.0 mm transverse osteotomies 3 days after the operation. The changes in the temperatures of the muscle tissues in front of the implants or the 3.0 mm transverse osteotomies were measured during the microwave treatments. To characterize the effects of titanium alloy internal fixations on apoptosis in the muscles after microwave treatment, we performed TUNEL assays, fluorescent real-time (quantitative) PCR, western blotting analyses, reactive oxygen species (ROS) detection and transmission electron microscopy examinations. Results The temperatures were markedly increased in the animals with the titanium alloy implants. Apoptosis in the muscle cells of the implanted group was significantly more extensive than that in the non-implanted control group at different time points. Transmission electron microscopy examinations of the skeletal muscles of the implanted groups revealed muscular mitochondrial swelling, vacuolization. ROS, Bax and Hsp70 were up-regulated, and Bcl-2 was down-regulated in the implanted group. Conclusion Our results suggest that titanium alloy internal fixations caused greater muscular tissue cell apoptosis following 2,450 MHz, 40 W microwave treatments in this rabbit femur fracture models. PMID:26132082

  20. Object Management Group object transaction service based on an X/Open and International Organization for Standardization open systems interconnection transaction processing kernel

    NASA Astrophysics Data System (ADS)

    Liang, J.; Sédillot, S.; Traverson, B.

    1997-09-01

    This paper addresses federation of a transactional object standard - Object Management Group (OMG) object transaction service (OTS) - with the X/Open distributed transaction processing (DTP) model and International Organization for Standardization (ISO) open systems interconnection (OSI) transaction processing (TP) communication protocol. The two-phase commit propagation rules within a distributed transaction tree are similar in the X/Open, ISO and OMG models. Building an OTS on an OSI TP protocol machine is possible because the two specifications are somewhat complementary. OTS defines a set of external interfaces without specific internal protocol machine, while OSI TP specifies an internal protocol machine without any application programming interface. Given these observations, and having already implemented an X/Open two-phase commit transaction toolkit based on an OSI TP protocol machine, we analyse the feasibility of using this implementation as a transaction service provider for OMG interfaces. Based on the favourable result of this feasibility study, we are implementing an OTS compliant system, which, by initiating the extensibility and openness strengths of OSI TP, is able to provide interoperability between X/Open DTP and OMG OTS models.

  1. The fibronectin-binding protein of Streptococcus pyogenes, SfbI, is involved in the internalization of group A streptococci by epithelial cells.

    PubMed Central

    Molinari, G; Talay, S R; Valentin-Weigand, P; Rohde, M; Chhatwal, G S

    1997-01-01

    Streptococcus pyogenes organisms (group A streptococci) are considered to be highly adhesive extracellular pathogens. However, it has recently been reported that S. pyogenes has the capacity to efficiently invade eukaryotic cells. In this study, we demonstrate that the interaction of S. pyogenes fibronectin-binding protein (SfbI) with fibronectin on nonphagocytic HEp-2 cells triggers bacterial internalization. Blocking of the SfbI adhesin by either antibodies against the whole protein or antibodies against the fibronectin-binding domains of SfbI, as well as pretreatment of HEp-2 cells with purified SfbI protein, prevents both S. pyogenes attachment and internalization. Inert latex beads precoated with the purified SfbI protein are ingested by eukaryotic cells, demonstrating that SfbI is per se enough to trigger the internalization process. Experiments performed with a recombinant SfbI domain encompassing the two fibronectin-binding regions of the SfbI molecule demonstrated that these binding regions are essential and sufficient to activate uptake by HEp-2 cells. These results demonstrate that the fibronectin-binding protein SfbI is involved in both S. pyogenes' attachment to and ingestion by HEp-2 cells and contribute to elucidation of the underlying molecular events leading to eukaryotic cell invasion by S. pyogenes. PMID:9119474

  2. The fibronectin-binding protein of Streptococcus pyogenes, SfbI, is involved in the internalization of group A streptococci by epithelial cells.

    PubMed

    Molinari, G; Talay, S R; Valentin-Weigand, P; Rohde, M; Chhatwal, G S

    1997-04-01

    Streptococcus pyogenes organisms (group A streptococci) are considered to be highly adhesive extracellular pathogens. However, it has recently been reported that S. pyogenes has the capacity to efficiently invade eukaryotic cells. In this study, we demonstrate that the interaction of S. pyogenes fibronectin-binding protein (SfbI) with fibronectin on nonphagocytic HEp-2 cells triggers bacterial internalization. Blocking of the SfbI adhesin by either antibodies against the whole protein or antibodies against the fibronectin-binding domains of SfbI, as well as pretreatment of HEp-2 cells with purified SfbI protein, prevents both S. pyogenes attachment and internalization. Inert latex beads precoated with the purified SfbI protein are ingested by eukaryotic cells, demonstrating that SfbI is per se enough to trigger the internalization process. Experiments performed with a recombinant SfbI domain encompassing the two fibronectin-binding regions of the SfbI molecule demonstrated that these binding regions are essential and sufficient to activate uptake by HEp-2 cells. These results demonstrate that the fibronectin-binding protein SfbI is involved in both S. pyogenes' attachment to and ingestion by HEp-2 cells and contribute to elucidation of the underlying molecular events leading to eukaryotic cell invasion by S. pyogenes.

  3. Internationally Educated Female Teachers' Transformative Lifelong Learning Experiences: Rethinking the Immigrant Experience through an Arts-Informed Group Process

    ERIC Educational Resources Information Center

    Brigham, Susan

    2011-01-01

    This article is based on two phases of a five year arts-informed study that involved 24 women who immigrated to Maritime Canada as adults and who were all teachers in their countries of origin. In groups of approximately six, research participants gathered together in workshops held in two teacher training institutions in two Maritime Provinces…

  4. Adaptation to cesarean birth: implementation of an international multisite study.

    PubMed

    Fawcett, Jacqueline; Aber, Cynthia; Weiss, Marianne; Haussler, Susan; Myers, Sheila Taylor; King, Charlette; Newton, Jennifer; Silva, Virginia

    2005-07-01

    The purpose of this column is to describe the implementation of an international multisite Roy adaptation model-based study of women's perceptions of and responses to cesarean birth. The need for the study arose from the concern that women's childbearing needs may not be met to their full satisfaction, especially if the infant is born by cesarean. Serendipity and networking played a part in the selection of four study sites in the United States (Boston, Milwaukee, Norfolk, Oklahoma City) and two in other countries (Finland, Australia). Data were collected by nursing students and staff nurses. Post-hoc consideration of the diversity of study sites revealed opportunities for examination of the influence of the contextual stimuli of culture and geographic region on the women's adaptation to cesarean birth. Strategies used to foster integration of teaching, practice, and research are discussed. PMID:15976041

  5. The Power of Cooperation in International Paleoclimate Science: Examples from the PAGES 2k Network and the Ocean2k Working Group

    NASA Astrophysics Data System (ADS)

    Addison, J. A.

    2015-12-01

    The Past Global Changes (PAGES) project of IGBP and Future Earth supports research to understand the Earth's past environment to improve future climate predictions and inform strategies for sustainability. Within this framework, the PAGES 2k Network was established to provide a focus on the past 2000 years, a period that encompasses Medieval Climate Anomaly warming, Little Ice Age cooling, and recent anthropogenically-forced climate change. The results of these studies are used for testing earth system models, and for understanding decadal- to centennial-scale variability, which is needed for long-term planning. International coordination and cooperation among the nine regional Working Groups that make up the 2k Network has been critical to the success of PAGES 2k. The collaborative approach is moving toward scientific achievements across the regional groups, including: (i) the development of a community-driven open-access proxy climate database; (ii) integration of multi-resolution proxy records; (iii) development of multivariate climate reconstructions; and (iv) a leap forward in the spatial resolution of paleoclimate reconstructions. The last addition to the 2k Network, the Ocean2k Working Group has further innovated the collaborative approach by: (1) creating an open, receptive environment to discuss ideas exclusively in the virtual space; (2) employing an array of real-time collaborative software tools to enable communication, group document writing, and data analysis; (3) consolidating executive leadership teams to oversee project development and manage grassroots-style volunteer pools; and (4) embracing the value-added role that international and interdisciplinary science can play in advancing paleoclimate hypotheses critical to understanding future change. Ongoing efforts for the PAGES 2k Network are focused on developing new standards for data quality control and archiving. These tasks will provide the foundation for new and continuing "trans-regional" 2k

  6. Group hypnotherapy versus group relaxation for smoking cessation: an RCT study protocol

    PubMed Central

    2012-01-01

    Background A significant number of smokers would like to stop smoking. Despite the demonstrated efficacy of pharmacological smoking cessation treatments, many smokers are unwilling to use them; however, they are inclined to try alternative methods. Hypnosis has a long-standing reputation in smoking cessation therapy, but its efficacy has not been scientifically proven. We designed this randomised controlled trial to evaluate the effects of group hypnosis as a method for smoking cessation, and we will compare the results of group hypnosis with group relaxation. Methods/Design This is a randomised controlled trial (RCT) to compare the efficacy of a single session of hypnosis with that of relaxation performed in groups of 8-15 smokers. We intend to include at least 220 participants in our trial. The inclusion criteria include smoking at least 5 cigarettes per day, not using other cessation methods and being willing to quit smoking. The intervention is performed by a trained hypnotist/relaxation therapist. Both groups first receive 40 min of mental preparation that is based on motivational interviewing. Then, a state of deep relaxation is induced in the hypnosis condition, and superficial relaxation is induced in the control condition. Suggestions are made in the hypnosis condition that aim to switch the mental self-image of the participants from that of smokers to that of non-smokers. Each intervention lasts for 40 min. The participants also complete questionnaires that assess their smoking status and symptoms of depression and anxiety at baseline, 2 weeks and 6 months post-intervention. In addition, saliva samples are collected to assess cotinine levels at baseline and at 6 months post-intervention. We also assess nicotine withdrawal symptoms at 2 weeks post-intervention. Discussion To the best of our knowledge, this RCT is the first to test the efficacy of group hypnosis versus group relaxation. Issues requiring discussion in the outcome paper include the lack of

  7. Women's perceptions of caesarean birth: a Roy international study.

    PubMed

    Fawcett, Jacqueline; Aber, Cynthia; Haussler, Susan; Weiss, Marianne; Myers, Sheila Taylor; Hall, Jaye L; Waters, V Lynn; King, Charlette; Tarkka, Marja-Terttu; Rantanen, Anja; Astedt-Kurki, Paivi; Newton, Jennifer; Silva, Virginia

    2011-10-01

    The purpose of this Roy adaptation model-based multi-site international mixed method study was to examine the relations of type of caesarean birth (unplanned/planned), number of caesarean births (primary/repeat), and preparation for caesarean birth to women's perceptions of and responses to caesarean birth. The sample included 488 women from the United States (n = 253), Finland (n = 213), and Australia (n = 22). Path analysis revealed direct effects for type of and preparation for caesarean birth on responses to caesarean birth, and an indirect effect for preparation on responses to caesarean birth through perception of birth the experience.

  8. Lessons Learned From an International, Multisite Simulation Research Study.

    PubMed

    Foronda, Cynthia; Alhusen, Jeanne

    2016-01-01

    The purpose of this article is to describe the process and lessons learned in conducting an international, multisite simulation research study. Key lessons include asking site leaders to complete human subjects training early, applying for a deferral agreement for multiple sites, standardization, seeking consultation, considering differences in simulation centers, and having a back-up plan if committed team members are unable to progress. Although challenging, this process yields many rewards and raises the state of the science to improve pedagogy and student learning outcomes. PMID:26779693

  9. Literacy Instruction in Mexico. International Studies in Education.

    ERIC Educational Resources Information Center

    Miller, Robert

    Beginning in 1978, a 20-year study charted the evolution of the public education system in Mexico, focusing on literacy instruction for various age groups and special populations. Drawing on descriptions of schools visited during the author's 13 visits to Mexico, this book describes Mexican educational practices, with the aim of helping U.S.…

  10. Young Adults, Technology, and Weight Loss: A Focus Group Study

    PubMed Central

    Moscou-Jackson, Gyasi; Allen, Jerilyn K.

    2015-01-01

    Overweight and obesity are a major concern in young adults. Technology has been integrated into many weight loss interventions; however little is known about the use of this technology in young adults. The purpose of this study was to explore through focus group sessions the opinions of young adults on the use of technology for weight loss. A total of 17 young adults, between 18 and 25 years of age, participated in three focus group sessions. Major results indicated that young adults have very little knowledge on the use of Smartphone technology for weight loss but would like to use this type of technology to help them lose weight. Results also indicated that young adults struggle to make healthy food choices and have priorities that outweigh exercise and they need support and guidance to make better decisions. In conclusion, young adults would be open to using Smartphone technology for weight loss but also need feedback and guidance to help make healthy decisions. PMID:25789170

  11. Dynamical study of the Atira group of asteroids

    NASA Astrophysics Data System (ADS)

    Ribeiro, A. O.; Roig, F.; De Prá, M. N.; Carvano, J. M.; DeSouza, S. R.

    2016-06-01

    We study the dynamics of the group of Atira asteroids, characterized by aphelion distance Q < 0.983 au. This group has a significant observational bias, and their number is expected to be an order of magnitude larger than is known today. Due to their orbital configuration, these asteroids may represent a potential danger to the Earth. Here, we construct dynamical maps of the region between 0.2 and 0.98 au using a simple chaos indicator, the mean standard deviation in semimajor axis, and also analyse the behaviour of the real Atira orbits by means of the diffusion coefficient in semimajor axis. Our results indicate that Atira asteroids are located in the most unstable regions of the inner Solar system, and their stability is determined by close encounters and collisions with Mercury, Venus, and the Earth. A fraction of the known Atiras may represent a potential threat to the Earth over a few 105 yr of evolution. We found two islands of low-eccentricity stable orbits that might harbour a long-lasting sub-population of Atiras not yet observed.

  12. Parents' perspectives on the MMR immunisation: a focus group study.

    PubMed Central

    Evans, M; Stoddart, H; Condon, L; Freeman, E; Grizzell, M; Mullen, R

    2001-01-01

    BACKGROUND: The uptake of the combined measles, mumps and rubella immunisation (MMR) in Britain has fallen since 1998, when a link was hypothesised with the development of bowel disorders and childhood autism. Despite reassurances about the safety of MMR, uptake levels remain lower than optimal. We need to understand what influences parents' decisions on whether to accept MMR or not so that health professionals can provide a service responsive to their needs. AIM: To investigate what influences parents' decisions on whether to accept or refuse the primary MMR immunisation and the impact of the recent controversy over its safety. DESIGN: Qualitative study using focus group discussions. SETTING: Forty-eight parents, whose youngest child was between 14 months and three years old, attended groups at community halls in six localities in Avon and Gloucestershire. METHODS: Purposive sampling strategy was used to include parents from a variety of socioeconomic backgrounds. Three groups comprised parents who had accepted MMR and three groups comprised parents who had refused MMR. Data analysis used modified grounded theory techniques incorporating the constant comparative method. RESULTS: All parents felt that the decision about MMR was difficult and stressful, and experienced unwelcome pressure from health professionals to comply. Parents were not convinced by Department of Health reassurances that MMR was the safest and best option for their children and many had accepted MMR unwillingly. Four key factors influenced parents' decisions: (a) beliefs about the risks and benefits of MMR compared with contracting the diseases, (b) information from the media and other sources about the safety of MMR, (c) confidence and trust in the advice of health professionals and attitudes towards compliance with this advice, and (d) views on the importance of individual choice within Government policy on immunisation. CONCLUSIONS: Parents wanted up-to-date information about the risks and

  13. First Light Observations from the International Study of Astronomy Reasoning (ISTAR) Database

    NASA Astrophysics Data System (ADS)

    Tatge, Coty B.; Slater, Stephanie; Slater, Timothy F.; Bretones, Paulo S.; McKinnon, David; Schleigh, Sharon

    2016-01-01

    During the period between Fall 2014 and Summer 2015, the International Astronomical Union reorganized its structure to include the IAU Working Group on Theory and Methods in Astronomy Education. The initial goals of that working group are 1) promoting Astronomy Education Research (AER) by adopting the international collaboration model used by astronomy researchers, 2) fostering international astronomy education and AER capacity through the development of networks, training and shared resources, and 3) improving astronomy education by describing research based approaches to the teaching and learning of astronomy. In support of those efforts, the working group began a collaboration with the Center for Astronomy & Physics Education Research to develop the International Study of Astronomy Reasoning (ISTAR) Database, an online, searchable research tool, intended to catalog, characterize, and provide access to all known astronomy education research production, world-wide. Beginning in the Summer of 2015, a test of ISTAR's functionality began with a survey of a previously uncatalogued set of test objects: U.S.-based doctoral dissertations and masters. This target population was selected for its familiarity to the ISTAR developers, and for its small expected sample size (50-75 objects). First light observations indicated that the sample exceeded 300 dissertation objects. These objects were characterized across multiple variables, including: year of production, document source, type of resource, empirical methodology, context, informal setting type, research construct, type of research subject, scientific content, language, and nation of production. These initial observations provide motivation to extend this project to observe masters levels thesis, which are anticipated to be ten times more numerous as doctoral dissertations, other peer-reviewed contributions, contributions from the larger international community.

  14. The Life Design Group: A Case Study Vignette in Group Career Construction Counseling

    ERIC Educational Resources Information Center

    Barclay, Susan R.; Stoltz, Kevin B.

    2016-01-01

    Providing cost efficient, yet effective, student services, including career services, is a critical component in higher education. Career services must include the perspectives of the 21st-century work place. We advocate for the delivery of career development services in a group format using a narrative approach to career counseling with college…

  15. Ohio Arms Control Study Group: Workshop I, June 24-26, 1976, The Ohio State University. Summary of Proceedings.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Mershon Center.

    The booklet summarizes proceedings of a conference coordinated by the Ohio Arms Control Study Group (OACSG) on the topic of United States-USSR relations and the influence of nuclear weapons upon international behavior and strategic thought. The OACSG is composed of faculty members from Ohio colleges and universities who have a vocational or…

  16. Study of blood groups in HIV seropositive patients.

    PubMed

    Sayal, S K; Das, A L; Nema, S K

    1996-01-01

    Blood groups in 104 cases of HIV infection and 300 normal persons were determined. A relatively increased incidence of HIV infection was observed in persons with blood group O and relativey lower incidence in blood group B. Incidence of HIV infection was also low in Rh negative subjects. These results suggest a possible relationship between the incidence of blood group and the natural defence mechanism against HIV infection.

  17. Multi-wavelengths studies of fossil galaxy groups

    NASA Astrophysics Data System (ADS)

    Khosroshahi, H. G.

    2016-09-01

    Fossil systems are understood to be the end product of galaxy mergers within groups and clusters. Their halo morphology points to their relaxed/virialised nature, thus allowing them to employed as observational probes for the evolution of cosmic structures, their thermodynamics and dark matter distribution. Cosmological simulations, and their underlying models, are broadly consistent with the early formation epoch for fossils. In a series of studies we have looked into the dark matter, IGM and galaxy properties, across a wide range of wavelengths, from X-ray through optical and IR to the Radio, to achieve a better understating of fossil systems, the attributed halo age, IGM heating and their AGNs and use them as laboratories to probe galaxy formation models. We combine luminosity gap with luminosity segregation to identify the most dynamically relaxed systems which allows us to reveal brand new connections between galaxies and their environments.

  18. Space station group activities habitability module study: A synopsis

    NASA Technical Reports Server (NTRS)

    Nixon, David; Glassman, Terry

    1987-01-01

    Space station habitability was studied by investigating crew activity routines, proximities, ergonomic envelopes, and group volumes. Ten alternative schematic interior designs were proposed. Preliminary conclusions include: (1) in-service interior modifications may be necessary and should be planned for; (2) design complexity will be increased if the module cluster is reduced from five to three; (3) the increased crew circulation attendant upon enhancement of space station activity may produce human traffic bottlenecks and should be planned for; (4) a single- or two-person quiet area may be desirable to provide crew members with needed solitude during waking hours; and (5) the decision to choose a two-shift or three-shift daily cycle will have a significant impact on the design configuration and operational efficiency of the human habitat.

  19. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (30th, Prague, Czech Republic, July 16-21, 2006). Volume 1

    ERIC Educational Resources Information Center

    Novotna, Jarmila, Ed.; Moraova, Hana, Ed.; Kratka, Magdalena, Ed.; Stehlikova, Nad'a, Ed.

    2006-01-01

    This volume of the 30th annual proceedings of the International Group for the Psychology of Mathematics Education conference presents: plenary panel papers; research forum papers; short oral communication papers; and poster presentation papers from the meeting. Information relating to discussion groups and working sessions is also provided.…

  20. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (31st, Seoul, Korea, July 8-13, 2007). Volume 1

    ERIC Educational Resources Information Center

    Woo, Jeong-Ho, Ed.; Lew, Hee-Chan, Ed.; Park, Kyo-Sik Park, Ed.; Seo, Dong-Yeop, Ed.

    2007-01-01

    The first volume of the 31st annual proceedings of the International Group for the Psychology of Mathematics Education conference presents plenary lectures; research forums; discussion groups; working sessions; short oral communications; and posters from the meeting. Plenary lecture papers include: (1) On Humanistic Mathematics Education: A…

  1. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (25th, Utrecht, The Netherlands, July 12-17, 2001). Volumes 1-4.

    ERIC Educational Resources Information Center

    van den Heuvel-Panhuizen, Marja, Ed.

    This document contains the proceedings of the 25th annual Conference of the International Group for the Psychology of Mathematics Education (PME). It features plenary lectures, research forums, discussion groups, working sessions, short oral communications, and poster presentations. Papers in Volume 1 include: (1) "The P in PME: Progress and…

  2. Attributes and National Behavior, Part 2: Modern International Relations Monograph Series. Distance Theory, A Comparison of Various Regional Groupings on 1966-69 Cooperation Data.

    ERIC Educational Resources Information Center

    Vincent, Jack E.

    This monograph is a computer printout which presents findings from an analysis of data on cooperation among 29 regional groupings. Regional groupings are interpreted as geographic areas such as Africa and Latin America and international organizations such as The North Atlantic Treaty Organization (NATO) and the Organization of American States…

  3. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (29th, Melbourne, Australia, July 10-15, 2005). Volume 1

    ERIC Educational Resources Information Center

    Chick, Helen L., Ed.; Vincent, Jill L., Ed.

    2005-01-01

    The first volume of the 29th annual conference of the International Group for the Psychology of Mathematics Education contains plenary lecture and research forum papers as listed below. Short oral communications papers, poster presentations, brief summaries of discussion groups, and working sessions are also included in the volume. The plenary…

  4. Incipient Studies of School-Based Decision Groups.

    ERIC Educational Resources Information Center

    Hunt, John J.

    To address the effectiveness, the process, and the results of decisionmaking groups that include both administrators and teachers, and to discern the difference between the effective and less effective decisionmaking groups, 107 test groups, each composed of one Florida elementary school principal and two teachers from the same school, were…

  5. Focus Group Study Exploring Factors Related to Frequent Sickness Absence

    PubMed Central

    van Rhenen, Willem

    2016-01-01

    Introduction Research investigating frequent sickness absence (3 or more episodes per year) is scarce and qualitative research from the perspective of frequent absentees themselves is lacking. The aim of the current study is to explore awareness, determinants of and solutions to frequent sickness absence from the perspective of frequent absentees themselves. Methods We performed a qualitative study of 3 focus group discussions involving a total of 15 frequent absentees. Focus group discussions were audiotaped and transcribed verbatim. Results were analyzed with the Graneheim method using the Job Demands Resources (JD–R) model as theoretical framework. Results Many participants were not aware of their frequent sickness absence and the risk of future long-term sickness absence. As determinants, participants mentioned job demands, job resources, home demands, poor health, chronic illness, unhealthy lifestyles, and diminished feeling of responsibility to attend work in cases of low job resources. Managing these factors and improving communication (skills) were regarded as solutions to reduce frequent sickness absence. Conclusions The JD–R model provided a framework for determinants of and solutions to frequent sickness absence. Additional determinants were poor health, chronic illness, unhealthy lifestyles, and diminished feeling of responsibility to attend work in cases of low job resources. Frequent sickness absence should be regarded as a signal that something is wrong. Managers, supervisors, and occupational health care providers should advise and support frequent absentees to accommodate job demands, increase both job and personal resources, and improve health rather than express disapproval of frequent sickness absence and apply pressure regarding work attendance. PMID:26872050

  6. Ten years of Developing International Volcanology Graduate Study Programs

    NASA Astrophysics Data System (ADS)

    Rose, W. I.

    2010-12-01

    In 2000 I reported at this symposium about multi-institutional graduate field trips to IAVCEI events, such as the Bali meeting and its importance in building international collegiality and awareness among the volcanology doctoral students. NSF was an enthusiastic supporter of these field sessions and this support has continued through the highly successful Pucon and Reykjavik sessions. International volcanology graduate program development began with several exchange programs. EHaz was a highly successful program (McGill, Simon Fraser, Michigan Tech, Buffalo, UNAM and Universidad de Colima) funded by the Department of Education (FIPSE) that moved students across North America where dozens of graduate students spent semesters of their study abroad and shared annual field trips and online student led graduate seminar classes. Michigan Tech’s volcanology graduate program started a Masters International program that combined Peace Corps service with hazards mitigation graduate study and students were placed by Peace Corps in countries with prominent natural hazards. The new program funded 2 year residences in foreign environments, principally in Pacific Latin America. NSF strongly supported this program from its inception, and eventually it gained NSF PIRE support. Dozens of students have initiated the 3 year program (15 completed) to date. A similar PIRE developed at UAF with a link to volcanology in the Russian Far East. One gain is the development of many socially-conscious research selections. Beginning this year transatlantic dual degree masters programs in volcanology are being offered by a consortium of US and European volcanology programs (Michigan Tech, Buffalo, Clermont Ferrand and University of Milan Bicocca), again aided by FIPSE funding. Students have dual advisors on both sides of the Atlantic and spend about half of their two year programs in Europe and half in US. Faculty also travel in the program and the four campuses are increasingly linked by

  7. The Adjustment Problems Faced by International and Overseas Chinese Students Studying in Taiwan Universities: A Comparison of Student and Faculty/Staff Perceptions

    ERIC Educational Resources Information Center

    Jenkins, John R.; Galloway, Fred

    2009-01-01

    Over the last 15 years the number of international students studying at universities in Taiwan has increased dramatically; however, to date, there have been few studies that measured the cultural adjustment problems that this diverse group of students experience. To remedy this problem, this study gathered data from 1,174 international students…

  8. Crisis Intervention Team (CIT) programs in rural communities: a focus group study.

    PubMed

    Skubby, David; Bonfine, Natalie; Novisky, Meghan; Munetz, Mark R; Ritter, Christian

    2013-12-01

    The Crisis Intervention Teams model (CIT) was originally developed as an urban model for police officers responding to calls about persons experiencing a mental illness crisis. Literature suggests that there is reason to believe that there may be unique challenges to adapting this model in rural settings. This study attempts to better understand these unique challenges. Thematic analysis of focus group interviews revealed that there were both external and internal barriers to developing CIT in their respective communities. Some of these barriers were a consequence of working in small communities and working within small police departments. Participants actively overcame these barriers through the realization that CIT was needed in their community, through collaborative efforts across disciplines, and through the involvement of mental health advocacy groups. These results indicate that CIT can be successfully implemented in rural communities.

  9. Using Typologies to Interpret Study Abroad Preferences of American Business Students: Applying a Tourism Framework to International Education

    ERIC Educational Resources Information Center

    Cardon, Peter W.; Marshall, Bryan; Poddar, Amit

    2011-01-01

    The authors describe research that applies a tourist framework to study abroad attitudes and preferences. A total of 371 university business students in the Southern region of the United States completed a survey that included the International Tourist Role scale and study abroad attitudes and preferences. These students were grouped into one of 4…

  10. The internal organization of hospitals: a descriptive study.

    PubMed Central

    Sloan, F A

    1980-01-01

    This study presents descriptive information on several dimensions of the internal organization of hospitals, with particular emphasis on medical staff, using data from two unique national surveys. Three alternative theories of hospital behavior by economists are described and evaluated with these data. The study also shows how standard bed size, teaching, and ownership categories relate to important features of hospital organization. In this way, understanding of these standard "control" variables is enhanced. For example, systematic organizational differences between proprietary and other hospitals are reported, holding bed size and teaching status constant. No single theory of hospital behavior emerges as dominant. The tables demonstrate the diversity of hospitals and the likelihood that no single model can adequately describe the behavior of all hospitals. PMID:7204062

  11. Stem Cell Gene Therapy for Fanconi Anemia: Report from the 1st International Fanconi Anemia Gene Therapy Working Group Meeting

    PubMed Central

    Tolar, Jakub; Adair, Jennifer E; Antoniou, Michael; Bartholomae, Cynthia C; Becker, Pamela S; Blazar, Bruce R; Bueren, Juan; Carroll, Thomas; Cavazzana-Calvo, Marina; Clapp, D Wade; Dalgleish, Robert; Galy, Anne; Gaspar, H Bobby; Hanenberg, Helmut; Von Kalle, Christof; Kiem, Hans-Peter; Lindeman, Dirk; Naldini, Luigi; Navarro, Susana; Renella, Raffaele; Rio, Paula; Sevilla, Julián; Schmidt, Manfred; Verhoeyen, Els; Wagner, John E; Williams, David A; Thrasher, Adrian J

    2011-01-01

    Survival rates after allogeneic hematopoietic cell transplantation (HCT) for Fanconi anemia (FA) have increased dramatically since 2000. However, the use of autologous stem cell gene therapy, whereby the patient's own blood stem cells are modified to express the wild-type gene product, could potentially avoid the early and late complications of allogeneic HCT. Over the last decades, gene therapy has experienced a high degree of optimism interrupted by periods of diminished expectation. Optimism stems from recent examples of successful gene correction in several congenital immunodeficiencies, whereas diminished expectations come from the realization that gene therapy will not be free of side effects. The goal of the 1st International Fanconi Anemia Gene Therapy Working Group Meeting was to determine the optimal strategy for moving stem cell gene therapy into clinical trials for individuals with FA. To this end, key investigators examined vector design, transduction method, criteria for large-scale clinical-grade vector manufacture, hematopoietic cell preparation, and eligibility criteria for FA patients most likely to benefit. The report summarizes the roadmap for the development of gene therapy for FA. PMID:21540837

  12. Buyer-seller negotiations: a comparison of domestic and international conditions in a pilot study with international business students.

    PubMed

    Yurtsever, Gülçimen; Kurt, Gizem; Hacioglu, Gungor

    2010-06-01

    This study examined the differences and similarities between domestic and international negotiations, using Kelley's Negotiation Game to measure the profit achieved. There were 58 participants in the international negotiation sample, 29 Turkish and 29 European students. There were 62 Turkish students in the domestic negotiations. All participants studied business or related topics at a university in Izmir. Student t tests indicated statistically significant differences in scores on misrepresentation of information, interpersonal attraction, peer evaluation of misrepresentation information, and satisfaction between domestic and international negotiations.

  13. Faith based aviation: An ethnographic study of missionary flights international

    NASA Astrophysics Data System (ADS)

    Cooper, Joseph H.

    The development of faith-based missionary aviation is a post-World War II phenomenon. The war effort demonstrated the value, utility, and global reach of aviation to remote, underdeveloped areas of the world. With the beginnings of a worldwide infrastructure for aviation, Christian aviators realized aviation could increase the range and effectiveness of their efforts to reach the world for Christ (Mellis, 2006). Although individual organizations provide statistical information and data about flight operations there is a lack of external evidence and relevant research literature confirming the scope and value of these faith based aviation organizations and operations. A qualitative, ethnographic study was conducted to document the activities of one faith-based aviation organization to gain an understanding of this little known aspect of civilian aviation. The study was conducted with Missionary Flights International (MFI) of Fort Pierce, FL which has been involved in faith-based, missionary aviation since its inception in 1964. As an aviation organization "MFI strives to offer affiliated missions the kind of efficient service and professionalism expected of an airline operation" (Missionary Flights International, 2013, p.1). MFI is a lifeline for missionaries to Haiti and the Dominican Republic, fulfilling their motto of "Standing in the Gap". MFI provides twice a week service to the island of Hispaniola and the Republic of Haiti. In this in-depth study insight and understanding was gained into the purpose of MFI, their daily routines and operations, and the challenges they face in maintaining their flight services to Haiti. This study provided documentation of the value and utility of such aviation efforts and of the individuals involved in this endeavor.

  14. A feasibility study for an International Year of Landcare

    NASA Astrophysics Data System (ADS)

    Mutota, E.; Arnalds, A.

    2009-04-01

    Human-induced activities place enormous pressures on the land worldwide, creating competition and conflict, and suboptimal use of the land. Climate change, loss of biodiversity and land degradation leads to decreasing productivity, food and water shortages, and reduced economic benefits, among others. In order to address these challenges and achieve sustainability goals, the need to change the way global resources are being utilized is crucial. A holistic and integrated community-based approach such as Landcare could be a viable approach to meet this worldwide challenge. Landcare is about committed people working together on land rehabilitation and restoration projects at the local level, transforming attitudes and stimulating new ideas among land users, generating support and building partnerships between and among local communities, governments and the private sector. Landcare initiatives have grown in a number of countries where success stories of actions on the ground clearly show the wider application of the Landcare approach in resolving many of the world's environmental problems and livelihood challenges. However, the potential of Landcare have not yet been widely exploited on a scale that really matters—as local actions build up towards global progress, there is more scope for unified efforts towards a global Landcare movement. Following the recommendation given at the International Forum on Soils, Society and Global Change in 2007 in Iceland (http://www.iisd.ca/YMB/SDFSS/), an International Year of Landcare should be established. Such a year would bring into focus efforts to build local capacity and share knowledge and experiences between provinces, countries and continents on Landcare. Additionally, holding a year concerned with Landcare would greatly contribute to the attainment of the Millennium Development Goals, the UN environmental conventions and many other sustainability goals. Our study supports the notion that Landcare offers a robust platform

  15. [Chronic pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

    PubMed

    Takács, Tamás; Czakó, László; Dubravcsik, Zsolt; Farkas, Gyula; Hegyi, Péter; Hritz, István; Kelemen, Dezső; Lásztity, Natália; Morvay, Zita; Oláh, Attila; Pap, Ákos; Párniczky, Andrea; Patai, Árpád; Sahin-Tóth, Miklós; Szentkereszti, Zsolt; Szmola, Richárd; Tiszlavicz, László; Szücs, Ákos

    2015-02-15

    Chronic pancreatitis is an inflammatory disease associated with structural and functional damage of the pancreas. In most cases pain, maldigestion and weight loss are the leading symptoms, which significantly worsen the quality of life. Correct diagnosis and differential diagnosis of chronic pancreatitis and treatment of these patients requires up-to-date and evidence based treatment guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidence. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and complemented and/or modified the international guidelines if it was necessary. 123 relevant clinical questions in 11 topics were defined. Evidence was classified according to the UpToDate® grading system. The draft of the guidelines were presented and discussed at the consensus meeting in September 12, 2014. All clinical questions were accepted with total or strong agreement. The present guideline is the first evidence based guideline for chronic pancreatitis in Hungary. This guideline provides very important and helpful data for tuition, everyday practice and proper financing of chronic pancreatitis. Therefore, the authors believe that these guidelines will widely become a basic reference in Hungary.

  16. [Acute pancreatitis. Evidence-based practice guidelines, prepared by the Hungarian Pancreatic Study Group].

    PubMed

    Hritz, István; Czakó, László; Dubravcsik, Zsolt; Farkas, Gyula; Kelemen, Dezső; Lásztity, Natália; Morvay, Zita; Oláh, Attila; Pap, Ákos; Párniczky, Andrea; Sahin-Tóth, Miklós; Szentkereszti, Zsolt; Szmola, Richárd; Szücs, Ákos; Takács, Tamás; Tiszlavicz, László; Hegyi, Péter

    2015-02-15

    Acute pancreatitis is one of the most common diseases of the gastrointestinal tract associated with significant morbidity and mortality that requires up-to-date and evidence based treatment guidelines. The Hungarian Pancreatic Study Group proposed to prepare evidence based guideline for the medical and surgical management of acute pancreatitis based on the available international guidelines and evidence. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and, if it was necessary, complemented and/or modified the international guidelines. All together 42 relevant clinical questions were defined in 11 topics (Diagnosis and etiology, Prognosis, Imaging, Fluid therapy, Intensive care management, Prevention of infectious complications, Nutrition, Biliary interventions, Post-endoscopic retrograde cholangio-pancreatography pancreatitis, Indication, timing and strategy for intervention in necrotizing pancreatitis, Timing of cholecystectomy [or endoscopic sphincterotomy]). Evidence was classified according to the UpToDate® grading system. The draft of the guideline was presented and discussed at the consensus meeting on September 12, 2014. 25 clinical questions with almost total (more than 95%) and 17 clinical questions with strong (more than 70%) agreement were accepted. The present guideline is the first evidence based acute pancreatitis guideline in Hungary. The guideline may provide important help for tuition, everyday practice and for establishment of proper finance of acute pancreatitis. Therefore, the authors believe that these guidelines will widely become as basic reference in Hungary.

  17. [Autoimmune pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

    PubMed

    Dubravcsik, Zsolt; Farkas, Gyula; Hegyi, Péter; Hritz, István; Kelemen, Dezső; Lásztity, Natália; Morvay, Zita; Oláh, Attila; Pap, Ákos; Párniczky, Andrea; Sahin-Tóth, Miklós; Szentkereszti, Zsolt; Szmola, Richárd; Takács, Tamás; Tiszlavicz, László; Szücs, Ákos; Czakó, László

    2015-02-22

    Autoimmune pancreatitis is a rare disease which can even mimic pancreatic tumor, however, unlike the latter, it requires not surgical but conservative management. Correct diagnosis and differential diagnosis of autoimmune pancreatitis and treatment of these patients requires up-to-date and evidence based management guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidences. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and complemented and/or modified the international guidelines if it was necessary. 29 relevant clinical questions in 4 topics were defined (Basics; Diagnosis; Differential diagnostics; Therapy). Evidence was classified according to the UpToDate(®) grading system. The draft of the guidelines was presented and discussed at the consensus meeting on September 12, 2014. All clinial questions were accepted with almost total (more than 95%) agreement. The present guideline is the first evidence based autoimmune pancreatitis guideline in Hungary. The guideline may provide very important and helpful data for tuition of autoimmune pancreatitis, for everyday practice and for establishing proper finance. Therefore, the authors believe that these guidelines will widely become a basic reference in Hungary.

  18. Human genetics studies: the case for group rights.

    PubMed

    Underkuffler, Laura S

    2007-01-01

    In this essay, the author focuses on an underlying theoretical issue which she believes seriously affects our collective response to the idea of group rights in the genetic-control context. That issue is to what extent are our responses to claims of group rights hampered by our bringing to the table (consciously or unconsciously) a model which is structured to acknowledge only individual concerns? Put another way, to what extent are our objections to group rights in this context a product of our inability (or refusal) to imagine the idea of group rights, rather than the product of truly substantive concerns?

  19. Experimental study of the microbial fuel cell internal resistance

    NASA Astrophysics Data System (ADS)

    Zhang, Pei-Yuan; Liu, Zhong-Liang

    The internal resistance, including activation loss internal resistance (AIR), ohmic loss internal resistance (OIR) and concentration loss internal resistance (CIR), is an important parameter that determines the performance of microbial fuel cells (MFCs). The experimental investigations were completed to estimate the contributions of these three components to the internal resistance. The internal resistance is found to vary with electric current, although it is almost a constant for the current is within a certain region. The largest component of the internal resistance is CIR except for small currents. The AIR decreases quickly for small current and reduces its decreasing rate as the current increases and approaches to a constant. The OIR is constant over the whole current range. The experiments also disclose that increasing the limiting current and reducing the concentration loss are both important for improving the MFC performance.

  20. Predictors of international students' psychological and sociocultural adjustment to the context of reception while studying at Aarhus University, Denmark.

    PubMed

    Ozer, Simon

    2015-12-01

    The number of international students engaging in intercultural education and thereby adjusting to cross-cultural transition has risen conspicuously as a consequence of globalization and increased mobility. This process of acculturation has been associated with increased creativity as well as adaptation challenges. This paper investigates international students' psychological and sociocultural adjustment to studying at Aarhus University in Denmark. Both international students (n = 129) and domestic students (n = 111) participated in the study. The international students did not report impaired psychological conditions as compared to the control group of domestic students. However, the international students reported a significantly lower level of social support. Social support and perceived discrimination were significant predictors of both psychological and sociocultural adjustment. Additionally, the level of English proficiency alone predicted sociocultural adjustment. Values of vertical individualism and horizontal collectivism predicted psychological adjustment. Finally, integration was found to be a significantly more adaptive acculturation orientation than separation in regard to sociocultural adjustment. These findings were discussed in relation to relevant international research and it was concluded that international students comprise a resourceful student sample and that the international academic environment at Aarhus University appears to be an adequately cultural and value-oriented good fit as a context of reception for the multicultural engagement of international students. PMID:26565736

  1. Predictors of international students' psychological and sociocultural adjustment to the context of reception while studying at Aarhus University, Denmark.

    PubMed

    Ozer, Simon

    2015-12-01

    The number of international students engaging in intercultural education and thereby adjusting to cross-cultural transition has risen conspicuously as a consequence of globalization and increased mobility. This process of acculturation has been associated with increased creativity as well as adaptation challenges. This paper investigates international students' psychological and sociocultural adjustment to studying at Aarhus University in Denmark. Both international students (n = 129) and domestic students (n = 111) participated in the study. The international students did not report impaired psychological conditions as compared to the control group of domestic students. However, the international students reported a significantly lower level of social support. Social support and perceived discrimination were significant predictors of both psychological and sociocultural adjustment. Additionally, the level of English proficiency alone predicted sociocultural adjustment. Values of vertical individualism and horizontal collectivism predicted psychological adjustment. Finally, integration was found to be a significantly more adaptive acculturation orientation than separation in regard to sociocultural adjustment. These findings were discussed in relation to relevant international research and it was concluded that international students comprise a resourceful student sample and that the international academic environment at Aarhus University appears to be an adequately cultural and value-oriented good fit as a context of reception for the multicultural engagement of international students.

  2. iSTAR: The International STudy on Astronomy Reasoning

    NASA Astrophysics Data System (ADS)

    Tatge, Coty B.; Slater, Timothy F.; Slater, Stephanie J.

    2015-08-01

    This paper reports the first steps taken in the International STudy on Astronomy Reasoning (iSTAR). The iSTAR Project is an attempt to look beyond traditional wisdom and practices in astronomy education, to discover the ways in which cognitive abilities and human culture interact to impact individuals’ understanding of and relationship to astronomy content knowledge. In contrast to many international studies that seek to rank nations by student performance on standardized tests, the iSTAR Project seeks to find ways that culture may unexpectedly enhance performance in astronomy. Using the Test of Astronomy Standards (TOAST) as a reasonable, initial proxy for the content knowledge a well educated person might know in astronomy, the iSTAR team then defined culture as a construct with five components: practices, traditional knowledge, historical and genealogical relationships, place-based knowledge, and language. Given the complexity of this construct, Stage 1 of the project focuses on the cultural component of language, and assumed that prior to the collection of data from students, the process of translating the TOAST could provide valuable expert-based information on the impact of language on astronomy knowledge. As such, the work began with a study of the translation process. For each of the languages used in the testing phase of the iSTAR protocol, a succession of translators and analysts were engaged, including two educated, non-astronomer native speakers, a native speaking astronomer, and a native speaking linguistics expert. Multiple translations were analyzed in order to make relevant meaning of differences in the translations, and provide commentary on the ways in which metaphor, idiom, cultural history are embedded in the language, providing potential advantages in the learning of astronomy. The first test languages were German, Hawaiian, and American Sign Language, and initial findings suggest that each of these languages provide specific advantages

  3. International ESCO business opportunities and challenges: a Japanese case study

    SciTech Connect

    Vine, E.; Murakoshi, C.

    1997-10-01

    Recently, US energy service companies (ESCOs) have begun to actively explore markets outside the US. Despite the needs of many countries for ESCO involvement, ESCOs face many challenges (i.e., marketing, financial, institutional, political and cultural barriers). Consequently, most of these firms pursue international project opportunities very selectively due to the costs and risks associated with project development. Despite these barriers, some ESCOs view international work as a strategic expansion of their business, assuming that there will be adequate business in the future to repay them for their initial investment. In this paper, the authors present the findings from a recently completed study on the proposed development of an ESCO industry in Japan. The study was based on four sources of information: (1) a review of the published and unpublished literature on ESCOs; (2) interviews with 26 ESCOs in the US, the US Department of Energy, and the National Association of Energy Service Companies (NAESCO); (3) ESCO presentations at the October 1996 NAESCO meeting; and (4) informal discussions with ESCO experts in the US. They believe that the lessons learned in this study can be transferred or applied to other countries interested in developing an ESCO industry. While energy prices have remained relatively stable over the last several years in Japan and energy capacity is not perceived as a near-term problem, other ``market drivers`` necessary for the emergence of a successful and vibrant ESCO industry exist in Japan. Despite the presence of these market drivers, significant barriers to the successful development of an ESCO industry exist in Japan.

  4. Proceedings of the Annual Conference of the International Group for the Psychology of Mathematics Education with the North American Chapter 12th PME-NA Conference (14th, Mexico, July 15-20, 1990), Volume 2.

    ERIC Educational Resources Information Center

    Booker, George, Ed.; Cobb, Paul, Ed.; de Mendicuti, Teresa N., Ed.

    This proceedings of the annual conference of the International Group for the Psychology of Mathematics Education (PME) includes the following research papers: "Children's Connections among Representations of Mathematical Ideas" (A. Alston & C.A. Maher); "Algebraic Syntax Errors: A Study with Secondary School Children" (A. Avila, F. Garcia, & T.…

  5. Proceedings of the Annual Meeting of the North American Chapter of the International Group for the Psychology of Mathematics Education (11th, New Brunswick, New Jersey, September 20-23, 1989), Volume 1: Research Reports.

    ERIC Educational Resources Information Center

    Maher, Carolyn A., Ed.; Goldin, Gerald A., Ed.; Davis, Robert B., Ed.

    This conference proceedings from annual conference of the North American Chapter of the International Group for the Psychology of Mathematics Education (PME-NA) contains the following research papers: "The Interactive Nature of Cognition and Affect in the Learning of Mathematics: Two Case Studies" (T.J. Bassarear); "The Value of Concept Forming in…

  6. Profiles in Successful Group Piano for Children: A Collective Case Study of Children's Group-Piano Lessons

    ERIC Educational Resources Information Center

    Pike, Pamela D.

    2013-01-01

    The purpose of this collective case study was to explore the best practices in beginning group-piano instruction. Four beginning and intermediate groups of piano students (N =20) were observed. Data were triangulated through in-class observation of students and teachers, teacher interviews and student questionnaires. The master teachers…

  7. Geochemical Study of Lichens in Tatun Volcano Group, North Taiwan

    NASA Astrophysics Data System (ADS)

    Kuan, Ssu-Yu

    2015-04-01

    Tatun Volcano Group (TVG) is located in the northwest of Taipei, the capital of Taiwan. Although the last activity was 200000 years ago, it is critical to monitor TVG because it is nearby metropolitan area. This study is part of the monitoring program and attempts to observe the geochemical relationship between lichen and volcanic gas. Lichens have been extensively used for monitoring atmospheric quality. Lichen can live in critical environments and can accumulate metals from atmosphere due to lack of excretion mechanism. Moreover, lichen can live long and growth in a low rate; therefore, lichen geochemistry can represent an average in a long term manner. In TVG, fruticose lichen can be seldom found due to the high concentration of SO2 in the atmosphere. However, foliose lichen and crustose lichen are not rare in the study area. In this study, lichens were collected from TVG and Nan-ao Trail which is in non-volcanic area. The cations were measured by ICP-MS. The geochemical results were analyzed by principal components analysis (PCA). It shows that there is no significant difference among non-volcanic lichens and the non-volcanic lichens are located at an end-member of two distinct trends. It is believed that the non-volcanic lichens indicate a geochemical baseline in north Taiwan and two trends may represent the mixing between two different types of volcanic gases in TVG and geochemical baseline. In this study, rare earth elements (REEs) were also measured. The results of non-volcanic and TVG lichens were normalized by North America Shale and TVG andesite, respectively. Both obtain a flat REE pattern, which confirm that TVG lichens receive metals from volcanic origin and non-volcanic lichens give information of background geochemistry in north Taiwan. In addition, a middle REE enrichment and distinct Ce negative anomaly can be observed. According to the previous studies, middle REE enrichment may be achieved by the selected adsorption of middle REEs by organic

  8. Technology User Groups and Early Childhood Education: A Preliminary Study

    ERIC Educational Resources Information Center

    Parette, Howard P.; Hourcade, Jack J.; Blum, Craig; Watts, Emily H.; Stoner, Julia B.; Wojcik, Brian W.; Chrismore, Shannon B.

    2013-01-01

    This article presents a preliminary examination of the potential of Technology User Groups as a professional development venue for early childhood education professionals in developing operational and functional competence in using hardware and software components of a Technology toolkit. Technology user groups are composed of varying numbers of…

  9. Permanent or Temporary Classroom Groups: A Field Study

    ERIC Educational Resources Information Center

    Zeff, Lawrence E.; Higby, Mary A.; Bossman, Larry J., Jr.

    2006-01-01

    Interviews of graduate and undergraduate students and faculty members at several urban universities were conducted during a 3-year period. The results suggest differences in satisfaction and performance with respect to temporary versus permanent groups and groups versus teams. Possible explanations for these differences are provided. The article…

  10. [Neurophysiological studies on group A xeroderma pigmentosum in early childhood].

    PubMed

    Iwakawa, Y; Shimohira, M; Kondo, S; Sato, Y

    1990-11-01

    Neurophysiological studies were performed on 8 patients with group A xeroderma pigmentosum during early childhood. EEG, ABR and NCV were normal during this period. In contrast, various sleep parameters detected by polysomnography showed abnormal findings even in the neurologically normal patient. Decreased % sleep REM was seen in a case, and decreased frequency of REMs were seen in another. Body movements were extremely high or low in frequency in 3 cases in whole night sleep. The distribution of body movements were abnormal; in control subjects, the frequency was higher in SREM and stage 1 than in slow wave sleep; in 7 cases, it was higher in slow wave sleep than in stage 1 or 2, or body movements were extremely frequent. Neurological examination revealed soft signs in various systems in early childhood. All cases except one showed hypotonia. Many cases were slow in learning to walk and the gait was unstable. Speech delay and decreased deep tendon reflexes, especially of patella, were seen in most cases. Since the neural deficits in XP may be related to the DNA repair defect, these findings indicate the possibility that some endogenous compounds distributing all over the nervous system might produce the DNA damages. Because the body movements during sleep are controlled by the nigrostriatal dopaminergic system, present data indicate that the basal ganglia might be one of the earliest degenerative systems in the CNS. Recently, some studies have suggested the possibility that oxygen radical mechanisms might be involved in the development of the dopamine neurodegenerative process in Parkinson's disease.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics

    SciTech Connect

    Akopov, Zaven; Amerio, Silvia; Asner, David; Avetisyan, Eduard; Barring, Olof; Beacham, James; Bernardi, Gregorio; Bethke, Siegfried; Boehnlein, Amber; Brooks, Travis; Browder, Thomas; Brun, Rene; Cartaro, Concetta; Cattaneo, Marco; Chen, Gang; Corney, David; Cranmer, Kyle; Culbertson, Ray; Dallmeier-Tiessen, Sunje; Denisov, Dmitri

    2013-03-27

    Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. An inter-experimental study group on HEP data preservation and long-term analysis was convened as a panel of the International Committee for Future Accelerators (ICFA). The group was formed by large collider-based experiments and investigated the technical and organisational aspects of HEP data preservation. An intermediate report was released in November 2009 addressing the general issues of data preservation in HEP. This paper includes and extends the intermediate report. It provides an analysis of the research case for data preservation and a detailed description of the various projects at experiment, laboratory and international levels. In addition, the paper provides a concrete proposal for an international organisation in charge of the data management and policies in high-energy physics.

  12. What Are Fair Study Benefits in International Health Research? Consulting Community Members in Kenya

    PubMed Central

    Njue, Maureen; Kombe, Francis; Mwalukore, Salim; Molyneux, Sassy; Marsh, Vicki

    2014-01-01

    Background Planning study benefits and payments for participants in international health research in low- income settings can be a difficult and controversial process, with particular challenges in balancing risks of undue inducement and exploitation and understanding how researchers should take account of background inequities. At an international health research programme in Kenya, this study aimed to map local residents' informed and reasoned views on the effects of different levels of study benefits and payments to inform local policy and wider debates in international research. Methods and Findings Using a relatively novel two-stage process community consultation approach, five participatory workshops involving 90 local residents from diverse constituencies were followed by 15 small group discussions, with components of information-sharing, deliberation and reflection to situate normative reasoning within debates. Framework Analysis drew inductively and deductively on voice- recorded discussions and field notes supported by Nvivo 10 software, and the international research ethics literature. Community members' views on study benefits and payments were diverse, with complex contextual influences and interplay between risks of giving ‘too many’ and ‘too few’ benefits, including the role of cash. While recognising important risks for free choice, research relationships and community values in giving ‘too many’, the greatest concerns were risks of unfairness in giving ‘too few’ benefits, given difficulties in assessing indirect costs of participation and the serious consequences for families of underestimation, related to perceptions of researchers' responsibilities. Conclusions Providing benefits and payments to participants in international research in low-income settings is an essential means by which researchers meet individual-level and structural forms of ethical responsibilities, but understanding how this can be achieved requires a careful

  13. What about N? A methodological study of sample-size reporting in focus group studies

    PubMed Central

    2011-01-01

    Background Focus group studies are increasingly published in health related journals, but we know little about how researchers use this method, particularly how they determine the number of focus groups to conduct. The methodological literature commonly advises researchers to follow principles of data saturation, although practical advise on how to do this is lacking. Our objectives were firstly, to describe the current status of sample size in focus group studies reported in health journals. Secondly, to assess whether and how researchers explain the number of focus groups they carry out. Methods We searched PubMed for studies that had used focus groups and that had been published in open access journals during 2008, and extracted data on the number of focus groups and on any explanation authors gave for this number. We also did a qualitative assessment of the papers with regard to how number of groups was explained and discussed. Results We identified 220 papers published in 117 journals. In these papers insufficient reporting of sample sizes was common. The number of focus groups conducted varied greatly (mean 8.4, median 5, range 1 to 96). Thirty seven (17%) studies attempted to explain the number of groups. Six studies referred to rules of thumb in the literature, three stated that they were unable to organize more groups for practical reasons, while 28 studies stated that they had reached a point of saturation. Among those stating that they had reached a point of saturation, several appeared not to have followed principles from grounded theory where data collection and analysis is an iterative process until saturation is reached. Studies with high numbers of focus groups did not offer explanations for number of groups. Too much data as a study weakness was not an issue discussed in any of the reviewed papers. Conclusions Based on these findings we suggest that journals adopt more stringent requirements for focus group method reporting. The often poor and

  14. Multilateral Organizations for the 1990's: A Report of a Series of Workshops, a Conference, and Various Study Groups. October 1984 to January 1985.

    ERIC Educational Resources Information Center

    United Nations Non-Governmental Liaison Service, New York, NY.

    Reporting on a series of workshops, a conference, and various study groups held during a three-month special program during the 39th General Assembly of the United Nations, this publication focuses on challenges presented to the United Nation's system of nearly 40 international organizations, regional institutions, international non-governmental…

  15. Many hands make light work: further studies in group evolution.

    PubMed

    Tomko, Nicholas; Harvey, Inman; Virgo, Nathaniel; Philippides, Andrew

    2014-01-01

    When niching or speciation is required to perform a task that has several different component parts, standard genetic algorithms (GAs) struggle. They tend to evaluate and select all individuals on the same part of the task, which leads to genetic convergence within the population. The goal of evolutionary niching methods is to enforce diversity in the population so that this genetic convergence is avoided. One drawback with some of these niching methods is that they require a priori knowledge or assumptions about the specific fitness landscape in order to work; another is that many such methods are not set up to work on cooperative tasks where fitness is only relevant at the group level. Here we address these problems by presenting the group GA, described earlier by the authors, which is a group-based evolutionary algorithm that can lead to emergent niching. After demonstrating the group GA on an immune system matching task, we extend the previous work and present two modified versions where the number of niches does not need to be specified ahead of time. In the random-group-size GA, the number of niches is varied randomly during evolution, and in the evolved-group-size GA the number of niches is optimized by evolution. This provides a framework in which we can evolve groups of individuals to collectively perform tasks with minimal a priori knowledge of how many subtasks there are or how they should be shared out.

  16. Student Use of Out-of-Class Study Groups in an Introductory Undergraduate Biology Course

    PubMed Central

    Rybczynski, Stephen M.; Schussler, Elisabeth E.

    2011-01-01

    Self-formed out-of-class study groups may benefit student learning; however, few researchers have quantified the relationship between study group use and achievement or described changes in study group usage patterns over a semester. We related study group use to performance on content exams, explored patterns of study group use, and qualitatively described student perceptions of study groups. A pre- and posttest were used to measure student content knowledge. Internet-based surveys were used to collect quantitative data on exam performance and qualitative data on study group usage trends and student perceptions of study groups. No relationship was found between gains in content knowledge and study group use. Students who participated in study groups did, however, believe they were beneficial. Four patterns of study group use were identified: students either always (14%) or never (55%) used study groups, tried but quit using them (22%), or utilized study groups only late in the semester (9%). Thematic analysis revealed preconceptions and in-class experiences influence student decisions to utilize study groups. We conclude that students require guidance in the successful use of study groups. Instructors can help students maximize study group success by making students aware of potential group composition problems, helping students choose group members who are compatible, and providing students materials on which to focus their study efforts. PMID:21364102

  17. International renal-cell cancer study. IV. Occupation.

    PubMed

    Mandel, J S; McLaughlin, J K; Schlehofer, B; Mellemgaard, A; Helmert, U; Lindblad, P; McCredie, M; Adami, H O

    1995-05-29

    The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found with employment in the blast-furnace or the coke-oven industry [relative risk (RR), 1.7; 95% confidence interval (CI), 1.1-2.7], the iron and steel industry (RR, 1.6; 95% CI, 1.2-2.2) and exposure to asbestos (RR, 1.4; 95% CI, 1.1-1.8), cadmium (RR, 2.0; 95% CI, 1.0-3.9), dry-cleaning solvents (RR, 1.4; 95% CI, 1.1-1.7), gasoline (RR, 1.6; 95% CI, 1.2-2.0) and other petroleum products (RR, 1.6; 95% CI, 1.3-2.1). Asbestos, petroleum products and dry-cleaning solvents appear to merit further investigation, in view of the relationship between risk and duration of employment or exposure and after adjustment for confounding. There was a negative association between RCC and education, but it was not consistent across all centers. Overall, the results of our multicenter case-control study suggest that occupation may be more important in the etiology of RCC than indicated by earlier studies. PMID:7768630

  18. International study tours: an avenue for personal growth.

    PubMed

    O'Reilly, Frances L; McCaw, William; Matt, John J; Kero, Patty

    2013-01-01

    This article consists of four integral parts of a complex process leading to successful implementation of international study tours. Our role as faculty members, in the development of these study tours, began with the proactive, reflective practice of examining our cultural experiences, perceptions, and understandings of our cultural knowledge, dispositions, and skills. Through these tours, educators from other countries and cultures come to The University of Montana and experience a collaboration of ideas and acquire a better understanding of education in the United States. To be successful these study tours need to go beyond content and include a variety of less tangible aspects ranging from the Initial Request for Proposals to the culminating activities. These study tours have led to the empowerment of educational leaders becoming instruments of positive change in their homeland. In turn, the relationships developed have transformed the faculty presenters and the institution in ways that are both measurable and immeasurable. Human relationships based on mutual respect and dignity underlie the success of educational tours.

  19. Radiation Therapy Planning for Early-Stage Hodgkin Lymphoma: Experience of the International Lymphoma Radiation Oncology Group

    SciTech Connect

    Maraldo, Maja V.; Dabaja, Bouthaina S.; Filippi, Andrea R.; Illidge, Tim; Tsang, Richard; Ricardi, Umberto; Petersen, Peter M.; Schut, Deborah A.; Garcia, John; Headley, Jayne; Parent, Amy; Guibord, Benoit; Ragona, Riccardo; Specht, Lena

    2015-05-01

    Purpose: Early-stage Hodgkin lymphoma (HL) is a rare disease, and the location of lymphoma varies considerably between patients. Here, we evaluate the variability of radiation therapy (RT) plans among 5 International Lymphoma Radiation Oncology Group (ILROG) centers with regard to beam arrangements, planning parameters, and estimated doses to the critical organs at risk (OARs). Methods: Ten patients with stage I-II classic HL with masses of different sizes and locations were selected. On the basis of the clinical information, 5 ILROG centers were asked to create RT plans to a prescribed dose of 30.6 Gy. A postchemotherapy computed tomography scan with precontoured clinical target volume (CTV) and OARs was provided for each patient. The treatment technique and planning methods were chosen according to each center's best practice in 2013. Results: Seven patients had mediastinal disease, 2 had axillary disease, and 1 had disease in the neck only. The median age at diagnosis was 34 years (range, 21-74 years), and 5 patients were male. Of the resulting 50 treatment plans, 15 were planned with volumetric modulated arc therapy (1-4 arcs), 16 with intensity modulated RT (3-9 fields), and 19 with 3-dimensional conformal RT (2-4 fields). The variations in CTV-to-planning target volume margins (5-15 mm), maximum tolerated dose (31.4-40 Gy), and plan conformity (conformity index 0-3.6) were significant. However, estimated doses to OARs were comparable between centers for each patient. Conclusions: RT planning for HL is challenging because of the heterogeneity in size and location of disease and, additionally, to the variation in choice of treatment techniques and field arrangements. Adopting ILROG guidelines and implementing universal dose objectives could further standardize treatment techniques and contribute to lowering the dose to the surrounding OARs.

  20. Mobile Air Quality Studies (MAQS)-an international project

    PubMed Central

    2010-01-01

    Due to an increasing awareness of the potential hazardousness of air pollutants, new laws, rules and guidelines have recently been implemented globally. In this respect, numerous studies have addressed traffic-related exposure to particulate matter using stationary technology so far. By contrast, only few studies used the advanced technology of mobile exposure analysis. The Mobile Air Quality Study (MAQS) addresses the issue of air pollutant exposure by combining advanced high-granularity spatial-temporal analysis with vehicle-mounted, person-mounted and roadside sensors. The MAQS-platform will be used by international collaborators in order 1) to assess air pollutant exposure in relation to road structure, 2) to assess air pollutant exposure in relation to traffic density, 3) to assess air pollutant exposure in relation to weather conditions, 4) to compare exposure within vehicles between front and back seat (children) positions, and 5) to evaluate "traffic zone"-exposure in relation to non-"traffic zone"-exposure. Primarily, the MAQS-platform will focus on particulate matter. With the establishment of advanced mobile analysis tools, it is planed to extend the analysis to other pollutants including NO2, SO2, nanoparticles and ozone. PMID:20380704