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Sample records for interpreting suboptimal business

  1. Reducing suboptimal employee decisions can build the business case for employee benefits.

    PubMed

    Goldsmith, Christopher; Cyboran, Steven F

    2013-01-01

    Suboptimal employee decisions are prevalent in employee benefit plans. Poor decisions have significant consequences for employees and employers. Improving participant decisions produces beneficial outcomes such as lower labor costs, higher productivity and better workforce management. The business case for employee benefits can be strengthened by applying lessons learned from the field of behavioral economics to employee benefit plan design and to workforce communication. This article explains the types of behavioral biases that influence suboptimal decisions and explores how enlightened employee benefit plan choice architecture and vivid behavioral messaging contribute to human and better organizational outcomes.

  2. How suboptimal is suboptimal choice?

    PubMed

    Hinnenkamp, Jay E; Shahan, Timothy A; Madden, Gregory J

    2017-01-01

    In a frequently used suboptimal-choice procedure pigeons choose between an alternative that delivers three food pellets with p = 1.0 and an alternative that delivers ten pellets with p = 0.2. Because pigeons reliably choose the probabilistic (suboptimal) alternative, the procedure has been proposed as a nonhuman analog of human gambling. The present experiments were conducted to evaluate two potential threats to the validity of this procedure. Experiments 1 and 2 evaluated if pigeons obtained food at a lower unit price (i.e., pecks per pellet) on the suboptimal alternative than on the optimal alternative. When pigeons worked under this suboptimal procedure they all preferred the suboptimal alternative despite some pigeons paying a higher price for food on that alternative. In Experiment 2, when the unit price ratio more closely approximated the inverse of the expected value ratio, pigeons continued to prefer the suboptimal alternative despite its economic suboptimality. Experiment 3 evaluated if, in accord with the string-theory of gambling, the valuation of the suboptimal alternative was increased when pigeons misattributed a subset of the suboptimal no-food trials to the optimal alternative. When trial sequences were arranged to minimize these possible attribution errors, pigeons still preferred the suboptimal alternative. These data remove two threats to the validity of the suboptimal choice procedure; threats that would have suggested that suboptimal choice reflects economic maximization.

  3. UBIT Issues: Guidance on Interpreting Unrelated Business Income Tax Rules.

    ERIC Educational Resources Information Center

    Roark, Stephen J.; Danley, Lisa M.

    1991-01-01

    The central issue in determining taxability of colleges' unrelated business income is the tax's purpose: to eliminate unfair advantage of exempt organizations over tax-paying businesses. If the business is not competing with outside vendors and can be related to the organization's exempt purposes, income is not taxable. (MSE)

  4. Four Interpretive Essays of: The Stout Report and the Business and Education Survey. Bulletin No. 4118.

    ERIC Educational Resources Information Center

    Oinonen, Charlotte M., Ed.

    Four essays are designed to provide perspective and dimension to the Stout Data Analysis and to the Business and Education Survey. The essayists who interpret the Stout and survey data represent the viewpoints of (1) business (David Horn), (2) a researcher in vocational education (Orville Nelson), (3) a vocational educator (Albert Pitts), and (4)…

  5. Interpretations

    NASA Astrophysics Data System (ADS)

    Bellac, Michel Le

    2014-11-01

    Although nobody can question the practical efficiency of quantum mechanics, there remains the serious question of its interpretation. As Valerio Scarani puts it, "We do not feel at ease with the indistinguishability principle (that is, the superposition principle) and some of its consequences." Indeed, this principle which pervades the quantum world is in stark contradiction with our everyday experience. From the very beginning of quantum mechanics, a number of physicists--but not the majority of them!--have asked the question of its "interpretation". One may simply deny that there is a problem: according to proponents of the minimalist interpretation, quantum mechanics is self-sufficient and needs no interpretation. The point of view held by a majority of physicists, that of the Copenhagen interpretation, will be examined in Section 10.1. The crux of the problem lies in the status of the state vector introduced in the preceding chapter to describe a quantum system, which is no more than a symbolic representation for the Copenhagen school of thought. Conversely, one may try to attribute some "external reality" to this state vector, that is, a correspondence between the mathematical description and the physical reality. In this latter case, it is the measurement problem which is brought to the fore. In 1932, von Neumann was first to propose a global approach, in an attempt to build a purely quantum theory of measurement examined in Section 10.2. This theory still underlies modern approaches, among them those grounded on decoherence theory, or on the macroscopic character of the measuring apparatus: see Section 10.3. Finally, there are non-standard interpretations such as Everett's many worlds theory or the hidden variables theory of de Broglie and Bohm (Section 10.4). Note, however, that this variety of interpretations has no bearing whatsoever on the practical use of quantum mechanics. There is no controversy on the way we should use quantum mechanics!

  6. Suboptimal choice behavior by pigeons.

    PubMed

    Stagner, Jessica P; Zentall, Thomas R

    2010-06-01

    Contrary to the law of effect and optimal foraging theory, pigeons show suboptimal choice behavior by choosing an alternative that provides 20% reinforcement over another that provides 50% reinforcement. They choose the 20% reinforcement alternative--in which 20% of the time, that choice results in a stimulus that always predicts reinforcement, and 80% of the time, it results in another stimulus that predicts its absence--rather than the 50% reinforcement alternative, which results in one of two stimuli, each of which predicts reinforcement 50% of the time. This choice behavior may be related to suboptimal human monetary gambling behavior, because in both cases, the organism overemphasizes the infrequent occurrence of the winning event and underemphasizes the more frequent occurrence of the losing event.

  7. Interpreted consultations as 'business as usual'? An analysis of organisational routines in general practices.

    PubMed

    Greenhalgh, Trisha; Voisey, Christopher; Robb, Nadia

    2007-09-01

    UK general practices operate in an environment of high linguistic diversity, because of recent large-scale immigration and of the NHS's commitment to provide a professional interpreter to any patient if needed. Much activity in general practice is co-ordinated and patterned into organisational routines (defined as repeated patterns of interdependent actions, involving multiple actors, bound by rules and customs) that tend to be stable and to persist. If we want to understand how general practices are responding to pressures to develop new routines, such as interpreted consultations, we need to understand how existing organisational routines change. This will then help us to address a second question, which is how the interpreted consultation itself is being enacted and changing as it becomes routinised (or not) in everyday general practice. In seeking answers to these two questions, we undertook a qualitative study of narratives of interpreted primary care consultations in three London boroughs with large minority ethnic populations. In 69 individual interviews and two focus groups, we sought accounts of interpreted consultations from service users, professional interpreters, family member interpreters, general practitioners, practice nurses, receptionists, and practice managers. We asked participants to tell us both positive and negative stories of their experiences. We analysed these data by searching for instances of concepts relating to the organisational routine, the meaning of the interpreted consultation to the practice, and the sociology of medical work. Our findings identified a number of general properties of the interpreted consultation as an organisational routine, including the wide variation in the form of adoption, the stability of the routine, the adaptability of the routine, and the strength of the routine. Our second key finding was that this variation could be partly explained by characteristics of the practice as an organisation, especially

  8. Comprehensive Interpretive Plans: The Next Step in Visitor Centeredness and Business Success?

    ERIC Educational Resources Information Center

    Koke, Judy

    2008-01-01

    For this author, the in-depth conversation about Comprehensive Interpretive Plans (CIP) began at an AAM Task Force meeting in May of 2004. Building on that initial discussion, the author explores the reasons, costs and benefits of engaging in the CIP development process, and makes the case for the museum field to develop proficiency in this…

  9. A shooting approach to suboptimal control

    NASA Technical Reports Server (NTRS)

    Hull, David G.; Sheen, Jyh-Jong

    1991-01-01

    The shooting method is used to solve the suboptimal control problem where the control history is assumed to be piecewise linear. Suboptimal solutions can be obtained without difficulty and can lead to accurate approximate controls and good starting multipliers for the regular shooting method by increasing the number of nodes. Optimal planar launch trajectories are presented for the advanced launch system.

  10. Small Business Management. Instructor's Manual on Interpretation of Small Business Analysis Data. Entrepreneurship Education for Adults--Program Development and Implementation.

    ERIC Educational Resources Information Center

    Minnesota Univ., St. Paul. Dept. of Agricultural Education.

    Tables and significant figures found in a small business analysis report are explained to provide instructors with suggestions on how these items can be used by students to improve the management of small businesses. Contents of the manual are organized into two parts. Part I, The Analysis Report, contains the following chapters: (A) Business…

  11. Energy exchanges in a Central Business District - Interpretation of Eddy Covariance and radiation flux measurements (London UK)

    NASA Astrophysics Data System (ADS)

    Kotthaus, S.; Grimmond, S.

    2013-12-01

    Global urbanisation brings increasingly dense and complex urban structures. To manage cities sustainably and smartly, currently and into the future under changing climates, urban climate research needs to advance in areas such as Central Business Districts (CBD) where human interactions with the environment are particularly concentrated. Measurement and modelling approaches may be pushed to their limits in dense urban settings, but if urban climate research is to contribute to the challenges of real cities those limits have to be addressed. The climate of cities is strongly governed by surface-atmosphere exchanges of energy, moisture and momentum. Observations of the relevant fluxes provide important information for improvement and evaluation of modelling approaches. Due to the CBD's heterogeneity, a very careful analysis of observations is required to understand the relevant processes. Current approaches used to interpret observations and set them in a wider context may need to be adapted for use in these more complex areas. Here, we present long-term observations of the radiation balance components and turbulent fluxes of latent heat, sensible heat and momentum in the city centre of London. This is one of the first measurement studies in a CBD covering multiple years with analysis at temporal scales from days to seasons. Data gathered at two sites in close vicinity, but with different measurement heights, are analysed to investigate the influence of source area characteristics on long-term radiation and turbulent fluxes. Challenges of source area modelling and the critical aspect of siting in such a complex environment are considered. Outgoing long- and short-wave radiation are impacted by the anisotropic nature of the urban surface and the high reflectance materials increasingly being used as building materials. Results highlight the need to consider the source area of radiometers in terms of diffuse and direct irradiance. Sensible heat fluxes (QH) are positive

  12. Suboptimal fractal coding scheme using iterative transformation

    NASA Astrophysics Data System (ADS)

    Kang, Hyun-Soo; Chung, Jae-won

    2001-05-01

    This paper presents a new fractal coding scheme to find a suboptimal transformation by performing an iterative encoding process. The optimal transformation can be defined as the transformation generating the closest attractor to an original image. Unfortunately, it is impossible in practice to find the optimal transformation, due to the heavy computational burden. In this paper, however, by means of some new theorems related with contractive transformations and attractors. It is shown that for some specific cases the optimal or suboptimal transformations can be obtained. The proposed method obtains a suboptimal transformation by performing iterative processes as is done in decoding. Thus, it requires more computation than the conventional method, but it improves the image quality. For a simple case where the optimal transformation can actually be found, the proposed method is experimentally evaluated against both the optimal method and the conventional method. For a general case where the optimal transformation in unavailable due to heavy computational complexity, the proposed method is also evaluated in comparison with the conventional method.

  13. Using Typologies to Interpret Study Abroad Preferences of American Business Students: Applying a Tourism Framework to International Education

    ERIC Educational Resources Information Center

    Cardon, Peter W.; Marshall, Bryan; Poddar, Amit

    2011-01-01

    The authors describe research that applies a tourist framework to study abroad attitudes and preferences. A total of 371 university business students in the Southern region of the United States completed a survey that included the International Tourist Role scale and study abroad attitudes and preferences. These students were grouped into one of 4…

  14. Design of suboptimal regulators for nonlinear systems

    NASA Technical Reports Server (NTRS)

    Balaram, J.; Saridis, G. N.

    1985-01-01

    An optimal feedback control law is preferred for the regulation of a deterministic nonlinear system. In this paper, a practical, iterative design method leading to a sequence of suboptimal control laws with successively improved performance is presented. The design method requires the determination of an upper bound to the performance of each successive control law. This is obtained by solving a partial differential inequality by means of a linear programming technique. Robustness properties and the application of the design method to the control of a robot manipulator arm are also presented.

  15. Suboptimal Exposure to Facial Expressions When Viewing Video Messages From a Small Screen: Effects on Emotion, Attention, and Memory

    ERIC Educational Resources Information Center

    Ravaja, Niklas; Kallinen, Kari; Saari, Timo; Keltikangas-Jarvinen, Liisa

    2004-01-01

    The authors examined the effects of suboptimally presented facial expressions on emotional and attentional responses and memory among 39 young adults viewing video (business news) messages from a small screen. Facial electromyography (EMG) and respiratory sinus arrhythmia were used as physiological measures of emotion and attention, respectively.…

  16. Factors influencing antiretroviral treatment suboptimal adherence among perinatally HIV-infected adolescents in Thailand

    PubMed Central

    Munir, Kerim; Kanabkaew, Cheeraya; Le Coeur, Sophie

    2017-01-01

    Background Existing studies have suggested decreased adherence and rebound in mortality in perinatally HIV-infected adolescents receiving antiretroviral therapy (ART) as compared to adults and young children. Methods We used both quantitative and qualitative approaches to identify factors influencing adherence among perinatally infected adolescents in Thailand. We analyzed data from 568 pairs of perinatally infected adolescents (aged 12–19) and their primary caregivers in the Teens Living With Antiretrovirals (TEEWA) study, a cross-sectional survey conducted in 2010–2012. We also conducted 12 in-depth interviews in 2014 with infected adolescents or their primary caregivers to elicit experiences of living with long-term ART. Results From the quantitative analysis, a total of 275 (48.4%) adolescents had evidence of suboptimal adherence based on this composite outcome: adolescents self-reported missing doses in the past 7 days, caregiver rating of overall adherence as suboptimal, or latest HIV-RNA viral load ≥1000 copies/ml. In multivariate logistic regression analysis, younger age, having grandparents or extended family members as the primary caregiver, caregiver-assessed poor intellectual ability, having a boy/girlfriend, frequent online chatting, self-reported unhappiness and easiness in asking doctors questions were significantly associated with suboptimal adherence. From the in-depth interviews, tensed relationships with caregivers, forgetfulness due to busy schedules, and fear of disclosing HIV status to others, especially boy/girlfriends, were important contributors to suboptimal adherence. Social and emotional support and counseling from peer group was consistently reported as a strong adherence-promoting factor. Conclusion Our findings highlight unique barriers of ART adherence among the perinatally infected adolescents. Future interventions should be targeted at helping adolescents to improve interpersonal relationships and build adaptive skills in

  17. Interpreting Standardized Assessment Test Scores and Setting Performance Goals in the Context of Student Characteristics: The Case of the Major Field Test in Business

    ERIC Educational Resources Information Center

    Bielinska-Kwapisz, Agnieszka; Brown, F. William; Semenik, Richard

    2012-01-01

    The Major Field Test in Business (MFT-B), a standardized assessment test of business knowledge among undergraduate business seniors, is widely used to measure student achievement. The Educational Testing Service, publisher of the assessment, provides data that allow institutions to compare their own MFT-B performance to national norms, but that…

  18. Optimal and suboptimal control technique for aircraft spin recovery

    NASA Technical Reports Server (NTRS)

    Young, J. W.

    1974-01-01

    An analytic investigation has been made of procedures for effecting recovery from equilibrium spin conditions for three assumed aircraft configurations. Three approaches which utilize conventional aerodynamic controls are investigated. Included are a constant control recovery mode, optimal recoveries, and a suboptimal control logic patterned after optimal recovery results. The optimal and suboptimal techniques are shown to yield a significant improvement in recovery performance over that attained by using a constant control recovery procedure.

  19. SUBOPT: A CAD program for suboptimal linear regulators

    NASA Technical Reports Server (NTRS)

    Fleming, P. J.

    1985-01-01

    An interactive software package which provides design solutions for both standard linear quadratic regulator (LQR) and suboptimal linear regulator problems is described. Intended for time-invariant continuous systems, the package is easily modified to include sampled-data systems. LQR designs are obtained by established techniques while the large class of suboptimal problems containing controller and/or performance index options is solved using a robust gradient minimization technique. Numerical examples demonstrate features of the package and recent developments are described.

  20. Suboptimal Light Conditions Influence Source-Sink Metabolism during Flowering

    PubMed Central

    Christiaens, Annelies; De Keyser, Ellen; Pauwels, Els; De Riek, Jan; Gobin, Bruno; Van Labeke, Marie-Christine

    2016-01-01

    Reliance on carbohydrates during flower forcing was investigated in one early and one late flowering cultivar of azalea (Rhododendron simsii hybrids). Carbohydrate accumulation, invertase activity, and expression of a purported sucrose synthase gene (RsSUS) was monitored during flower forcing under suboptimal (natural) and optimal (supplemental light) light conditions, after a cold treatment (7°C + dark) to break flower bud dormancy. Post-production sucrose metabolism and flowering quality was also assessed. Glucose and fructose concentrations and invertase activity increased in petals during flowering, while sucrose decreased. In suboptimal light conditions RsSUS expression in leaves increased as compared to optimal light conditions, indicating that plants in suboptimal light conditions have a strong demand for carbohydrates. However, carbohydrates in leaves were markedly lower in suboptimal light conditions compared to optimal light conditions. This resulted in poor flowering of plants in suboptimal light conditions. Post-production flowering relied on the stored leaf carbon, which could be accumulated under optimal light conditions in the greenhouse. These results show that flower opening in azalea relies on carbohydrates imported from leaves and is source-limiting under suboptimal light conditions. PMID:26973689

  1. Effects of Suboptimal Bidding in Combinatorial Auctions

    NASA Astrophysics Data System (ADS)

    Schneider, Stefan; Shabalin, Pasha; Bichler, Martin

    Though the VCG auction assumes a central place in the mechanism design literature, there are a number of reasons for favoring iterative combinatorial auction designs. Several promising ascending auction formats have been developed throughout the past few years based on primal-dual and subgradient algorithms and linear programming theory. Prices are interpreted as a feasible dual solution and the provisional allocation is interpreted as a feasible primal solution. iBundle( 3) (Parkes and Ungar 2000), dVSV (de Vries et al. 2007) and the Ascending Proxy auction (Ausubel and Milgrom 2002) result in VCG payoffs when the coalitional value function satisfies the buyer submodularity condition and bidders bid straightforward, which is an expost Nash equilibrium in that case. iBEA and CreditDebit auctions (Mishra and Parkes 2007) do not even require the buyer submodularity condition and achieve the same properties for general valuations. In many situations, however, one cannot assume bidders to bid straightforward and it is not clear from the theory how these non-linear personalized price auctions (NLPPAs) perform in this case. Robustness of auctions with respect to different bidding behavior is therefore a critical issue for any application. We have conducted a large number of computational experiments to analyze the performance of NLPPA designs with respect to different bidding strategies and different valuation models. We compare the results of NLPPAs to those of the VCG auction and those of iterative combinatorial auctions with approximate linear prices, such as ALPS (Bichler et al. 2009) and the Combinatorial Clock auction (Porter et al. 2003).

  2. On the Origins of Suboptimality in Human Probabilistic Inference

    PubMed Central

    Acerbi, Luigi; Vijayakumar, Sethu; Wolpert, Daniel M.

    2014-01-01

    Humans have been shown to combine noisy sensory information with previous experience (priors), in qualitative and sometimes quantitative agreement with the statistically-optimal predictions of Bayesian integration. However, when the prior distribution becomes more complex than a simple Gaussian, such as skewed or bimodal, training takes much longer and performance appears suboptimal. It is unclear whether such suboptimality arises from an imprecise internal representation of the complex prior, or from additional constraints in performing probabilistic computations on complex distributions, even when accurately represented. Here we probe the sources of suboptimality in probabilistic inference using a novel estimation task in which subjects are exposed to an explicitly provided distribution, thereby removing the need to remember the prior. Subjects had to estimate the location of a target given a noisy cue and a visual representation of the prior probability density over locations, which changed on each trial. Different classes of priors were examined (Gaussian, unimodal, bimodal). Subjects' performance was in qualitative agreement with the predictions of Bayesian Decision Theory although generally suboptimal. The degree of suboptimality was modulated by statistical features of the priors but was largely independent of the class of the prior and level of noise in the cue, suggesting that suboptimality in dealing with complex statistical features, such as bimodality, may be due to a problem of acquiring the priors rather than computing with them. We performed a factorial model comparison across a large set of Bayesian observer models to identify additional sources of noise and suboptimality. Our analysis rejects several models of stochastic behavior, including probability matching and sample-averaging strategies. Instead we show that subjects' response variability was mainly driven by a combination of a noisy estimation of the parameters of the priors, and by

  3. Modelling mould growth under suboptimal environmental conditions and inoculum size.

    PubMed

    Garcia, Daiana; Ramos, Antonio J; Sanchis, Vicente; Marín, Sonia

    2010-10-01

    Predictive models can be a tool to develop strategies to prevent mould development and consequently mycotoxin production. The aims of this work were to assess the impact of a) high/low levels of inoculum and b) optimal/suboptimal environmental conditions on fungal responses based on both kinetic and probabilistic models. Different levels of spore suspensions of Aspergillus carbonarius and Penicillium expansum were prepared and inoculated centrally with a needlepoint load on malt extract agar (MEA) with 50 replicates. While optimum conditions led to a colony diameter increase which followed Baranyi's function, suboptimal conditions led to different grow functions. In general, growth rate (mu) and lag phase (lambda) were normally distributed. Specifically, the growth rate (mu) showed similar distributions under optimal growth conditions, regardless of the inoculum level, while suboptimal a(w) and temperature conditions led to higher kurtosis distributions, mainly when the inoculum levels were low. Regarding lambda, more skewed distributions were observed, mainly when the inoculum levels were low. Probability models were not much affected by the inoculum size. Lower probabilities of growth were in general predicted under marginal conditions at a given time for both strains. The slopes of the probability curves were smaller under suboptimal growth conditions due to wider distributions. Results showed that a low inoculum level and suboptimal conditions lead to high variability of the estimated growth parameters and growth probability.

  4. Rough-Wall Channel Analysis Using Suboptimal Control Theory

    NASA Technical Reports Server (NTRS)

    Flores, O.; Jimenez, J.; Tenpleton, J.

    2003-01-01

    The original aim of this work was to shed some light on the physics of turbulence over rough walls using large-eddy simulations and the suboptimal-control wall boundary conditions introduced by Nicoud et al. It was hoped that, if that algorithm was used to fit the mean velocity profile of the simulations to that of a rough-walled channel, instead of to a smooth one, the wall stresses introduced by the control algorithm would give some indication of what aspects of rough walls are most responsible for the modification of the flow in real turbulence. It was similarly expected that the structure of the resulting velocity fluctuations would share some of the characteristics of rough-walled flows, thus again suggesting what is intrinsic and what is accidental in the effect of geometric wall roughness. A secondary goal was to study the effect of 'unphysical' boundary conditions on the outside flow by observing how a relatively major change of the target velocity profile, and therefore presumably of the applied wall stresses, modifies properties such as the dominant length scales of the velocity fluctuations away from the wall. As will be seen below, this secondary goal grew more important during the course of the study, which was carried out during a short summer visit of the first two authors to the CTR. It became clear that there are open questions about the way in which the control algorithm models the boundary conditions, even for smooth walls, and that these questions make the physical interpretation of the results difficult. Considerable more work in that area seems to be needed before even relatively advanced large-eddy simulations, such as these, can be used to draw conclusions about the physics of wall-bounded turbulent flows. The numerical method is the same as in Nicoud et al. The modifications introduced in the original code are briefly described in section 2, but the original paper should be consulted for a full description of the algorithm. The results are

  5. Hepatic metabolite profiles in mice with a suboptimal selenium status.

    PubMed

    Geillinger, Kerstin E; Rathmann, Daniel; Köhrle, Josef; Fiamoncini, Jarlei; Daniel, Hannelore; Kipp, Anna P

    2014-09-01

    Selenium is an essential trace element and mediates its functions via various selenoproteins such as glutathione peroxidases or thioredoxin reductases. A suboptimal selenium supply causes metabolic disturbances and is associated with an increased risk to develop different disorders, including cancer or cardiovascular diseases. This study aimed to assess the impact of a suboptimal selenium status on the hepatic metabolome of male mice analyzed by a targeted liquid chromatography/tandem mass spectrometry and a method based on non-targeted gas chromatography hyphenated with mass spectrometry. Feeding animals a diet with about half of the recommended selenium content supplied as selenomethionine caused liver glutathione peroxidase and thioredoxin reductase activities to decline and lipid peroxidation to increase. Serum T3 thyroid hormone concentration also declined via a reduced hepatic deiodinase activity. Metabolite profiling revealed predominantly changes in cysteine and carbon-1 metabolism as well as in selected lipid subclasses. In particular the concentrations of palmitoylcarnitines and oleoylcarnitines (C18:1 and C16:1) and various phosphatidylcholine species containing saturated fatty acids were elevated. Increased taurine levels suggested an enhanced cysteine flux through the salvage pathway whereas increased homocysteine levels appeared to be a consequence of a massive down-regulation of cystathionine β lyase (cystathionine β synthase) and a reduced flux through the transsulfuration pathway. The findings demonstrate that a suboptimal selenium status causes alterations in lipid and carbon-1 metabolism in mouse liver. These changes may contribute to the development of diseases associated with a suboptimal selenium status.

  6. Central suboptimal H ∞ control design for nonlinear polynomial systems

    NASA Astrophysics Data System (ADS)

    Basin, Michael V.; Shi, Peng; Calderon-Alvarez, Dario

    2011-05-01

    This article presents the central finite-dimensional H ∞ regulator for nonlinear polynomial systems, which is suboptimal for a given threshold γ with respect to a modified Bolza-Meyer quadratic criterion including the attenuation control term with the opposite sign. In contrast to the previously obtained results, the article reduces the original H ∞ control problem to the corresponding optimal H 2 control problem, using this technique proposed in Doyle et al. [Doyle, J.C., Glover, K., Khargonekar, P.P., and Francis, B.A. (1989), 'State-space Solutions to Standard H 2 and H ∞ Control Problems', IEEE Transactions on Automatic Control, 34, 831-847]. This article yields the central suboptimal H ∞ regulator for nonlinear polynomial systems in a closed finite-dimensional form, based on the optimal H 2 regulator obtained in Basin and Calderon-Alvarez [Basin, M.V., and Calderon-Alvarez, D. (2008b), 'Optimal Controller for Uncertain Stochastic Polynomial Systems', Journal of the Franklin Institute, 345, 293-302]. Numerical simulations are conducted to verify performance of the designed central suboptimal regulator for nonlinear polynomial systems against the central suboptimal H ∞ regulator available for the corresponding linearised system.

  7. National Endoscopy Quality Improvement Program Remains Suboptimal in Korea

    PubMed Central

    Cha, Jae Myung; Moon, Jeong Seop; Chung, Il-Kwun; Kim, Jin-Oh; Im, Jong Pil; Cho, Yu Kyung; Kim, Hyun Gun; Lee, Sang Kil; Lee, Hang Lak; Jang, Jae Young; Kim, Eun Sun; Jung, Yunho; Moon, Chang Mo; Kim, Yeol; Park, Bo Young

    2016-01-01

    Background/Aims We evaluated the characteristics of the National Cancer Screening Program (NCSP) and opinions regarding the National Endoscopy Quality Improvement Program (NEQIP). Methods We surveyed physicians performing esophagogastroduodenoscopy and/or colonoscopy screenings as part of the NCSP via e-mail between July and August in 2015. The 32-item survey instrument included endoscopic capacity, sedation, and reprocessing of endoscopes as well as opinions regarding the NEQIP. Results A total of 507 respondents were analyzed after the exclusion of 40 incomplete answers. Under the current capacity of the NCSP, the typical waiting time for screening endoscopy was less than 4 weeks in more than 90% of endoscopy units. Performance of endoscopy reprocessing was suboptimal, with 28% of respondents using unapproved disinfectants or not knowing the main ingredient of their disinfectants and 15% to 17% of respondents not following reprocessing protocols. Agreement with the NEQIP was optimal, because only 5.7% of respondents did not agree with NEQIP; however, familiarity with the NEQIP was suboptimal, because only 37.3% of respondents were familiar with the NEQIP criteria. Conclusions The NEQ-IP remains suboptimal in Korea. Given the suboptimal performance of endoscopy reprocessing and low familiarity with the NEQIP, improved quality in endoscopy reprocessing and better understanding of the NEQIP should be emphasized in Korea. PMID:27282270

  8. Optimality and sub-optimality in a bacterial growth law.

    PubMed

    Towbin, Benjamin D; Korem, Yael; Bren, Anat; Doron, Shany; Sorek, Rotem; Alon, Uri

    2017-01-19

    Organisms adjust their gene expression to improve fitness in diverse environments. But finding the optimal expression in each environment presents a challenge. We ask how good cells are at finding such optima by studying the control of carbon catabolism genes in Escherichia coli. Bacteria show a growth law: growth rate on different carbon sources declines linearly with the steady-state expression of carbon catabolic genes. We experimentally modulate gene expression to ask if this growth law always maximizes growth rate, as has been suggested by theory. We find that the growth law is optimal in many conditions, including a range of perturbations to lactose uptake, but provides sub-optimal growth on several other carbon sources. Combining theory and experiment, we genetically re-engineer E. coli to make sub-optimal conditions into optimal ones and vice versa. We conclude that the carbon growth law is not always optimal, but represents a practical heuristic that often works but sometimes fails.

  9. On Finding All Suboptimal Foldings of an RNA Molecule

    NASA Astrophysics Data System (ADS)

    Zuker, Michael

    1989-04-01

    An algorithm and a computer program have been prepared for determining RNA secondary structures within any prescribed increment of the computed global minimum free energy. The mathematical problem of determining how well defined a minimum energy folding is can now be solved. All predicted base pairs that can participate in suboptimal structures may be displayed and analyzed graphically. Representative suboptimal foldings are generated by selecting these base pairs one at a time and computing the best foldings that contain them. A distance criterion that ensures that no two structures are ``too close'' is used to avoid multiple generation of similar structures. Thermodynamic parameters, including free-energy increments for single-base stacking at the ends of helices and for terminal mismatched pairs in interior and hairpin loops, are incorporated into the underlying folding model of the above algorithm.

  10. Suboptimal quantum-error-correcting procedure based on semidefinite programming

    SciTech Connect

    Yamamoto, Naoki; Hara, Shinji; Tsumura, Koji

    2005-02-01

    In this paper, we consider a simplified error-correcting problem: for a fixed encoding process, to find a cascade connected quantum channel such that the worst fidelity between the input and the output becomes maximum. With the use of the one-to-one parametrization of quantum channels, a procedure finding a suboptimal error-correcting channel based on a semidefinite programming is proposed. The effectiveness of our method is verified by an example of the bit-flip channel decoding.

  11. Design of suboptimal adaptive filter for stochastic systems

    NASA Astrophysics Data System (ADS)

    Ahn, Jun Il; Shin, Vladimir

    2005-12-01

    In this paper, the problem of estimating the system state in for linear discrete-time systems with uncertainties is considered. In [1], [2], we have proposed the fusion formula (FF) for an arbitrary number of correlated and uncorrelated estimates. The FF is applied to detection and filtering problem. The new suboptimal adaptive filter with parallel structure is herein proposed. In consequence of parallel structure of the proposed filter, parallel computers can be used for their design. A lower computational complexity and lower memory demand are achieved with the proposed filter than in the optimal adaptive Lainiotis-Kalman filter. Example demonstrates the accuracy of the new filter.

  12. Optimal inference with suboptimal models: Addiction and active Bayesian inference

    PubMed Central

    Schwartenbeck, Philipp; FitzGerald, Thomas H.B.; Mathys, Christoph; Dolan, Ray; Wurst, Friedrich; Kronbichler, Martin; Friston, Karl

    2015-01-01

    When casting behaviour as active (Bayesian) inference, optimal inference is defined with respect to an agent’s beliefs – based on its generative model of the world. This contrasts with normative accounts of choice behaviour, in which optimal actions are considered in relation to the true structure of the environment – as opposed to the agent’s beliefs about worldly states (or the task). This distinction shifts an understanding of suboptimal or pathological behaviour away from aberrant inference as such, to understanding the prior beliefs of a subject that cause them to behave less ‘optimally’ than our prior beliefs suggest they should behave. Put simply, suboptimal or pathological behaviour does not speak against understanding behaviour in terms of (Bayes optimal) inference, but rather calls for a more refined understanding of the subject’s generative model upon which their (optimal) Bayesian inference is based. Here, we discuss this fundamental distinction and its implications for understanding optimality, bounded rationality and pathological (choice) behaviour. We illustrate our argument using addictive choice behaviour in a recently described ‘limited offer’ task. Our simulations of pathological choices and addictive behaviour also generate some clear hypotheses, which we hope to pursue in ongoing empirical work. PMID:25561321

  13. Suboptimal Choice in Pigeons: Stimulus Value Predicts Choice over Frequencies

    PubMed Central

    Bailey, Alexandria R.; Chow, Jonathan J.; Beckmann, Joshua S.; Zentall, Thomas R.

    2016-01-01

    Pigeons have shown suboptimal gambling-like behavior when preferring a stimulus that infrequently signals reliable reinforcement over alternatives that provide greater reinforcement overall. As a mechanism for this behavior, recent research proposed that the stimulus value of alternatives with more reliable signals for reinforcement will be preferred relatively independently of their frequencies. The present study tested this hypothesis using a simplified design of a Discriminative alternative that, 50% of the time, led to either a signal for 100% reinforcement or a blackout period indicative of 0% reinforcement against a Nondiscriminative alternative that always led to a signal that predicted 50% reinforcement. Pigeons showed a strong preference for the Discriminative alternative that remained despite reducing the frequency of the signal for reinforcement in subsequent phases to 25% and then 12.5%. In Experiment 2, using the original design of Experiment 1, the stimulus following choice of the Nondiscriminative alternative was increased to 75% and then to 100%. Results showed that preference for the Discriminative alternative decreased only when the signals for reinforcement for the two alternatives predicted the same probability of reinforcement. The ability of several models to predict this behavior are discussed, but the terminal link stimulus value offers the most parsimonious account of this suboptimal behavior. PMID:27441394

  14. Optimality and sub-optimality in a bacterial growth law

    PubMed Central

    Towbin, Benjamin D.; Korem, Yael; Bren, Anat; Doron, Shany; Sorek, Rotem; Alon, Uri

    2017-01-01

    Organisms adjust their gene expression to improve fitness in diverse environments. But finding the optimal expression in each environment presents a challenge. We ask how good cells are at finding such optima by studying the control of carbon catabolism genes in Escherichia coli. Bacteria show a growth law: growth rate on different carbon sources declines linearly with the steady-state expression of carbon catabolic genes. We experimentally modulate gene expression to ask if this growth law always maximizes growth rate, as has been suggested by theory. We find that the growth law is optimal in many conditions, including a range of perturbations to lactose uptake, but provides sub-optimal growth on several other carbon sources. Combining theory and experiment, we genetically re-engineer E. coli to make sub-optimal conditions into optimal ones and vice versa. We conclude that the carbon growth law is not always optimal, but represents a practical heuristic that often works but sometimes fails. PMID:28102224

  15. Moments of solutions of evolution equations and suboptimal programmed controls

    NASA Astrophysics Data System (ADS)

    Khrychev, D. A.

    2007-08-01

    Moments of solutions of non-linear differential equations subjected to random perturbations satisfy infinite systems of equations that do not contain finite closed subsystems. One of the methods for approximate solution of such infinite systems consists in replacing them by finite systems obtained from the original one as a result of equating to zero all the moments of sufficiently high order. It is shown that the moments of solutions of a wide class of ordinary differential equations, as well as of certain classes of partial differential equations, are approximated by solutions of those finite systems. The results obtained are used for constructing suboptimal programmed controls of dynamical systems with random parameters. Bibliography: 10 titles.

  16. Suboptimal greedy power allocation schemes for discrete bit loading.

    PubMed

    Al-Hanafy, Waleed; Weiss, Stephan

    2013-01-01

    We consider low cost discrete bit loading based on greedy power allocation (GPA) under the constraints of total transmit power budget, target BER, and maximum permissible QAM modulation order. Compared to the standard GPA, which is optimal in terms of maximising the data throughput, three suboptimal schemes are proposed, which perform GPA on subsets of subchannels only. These subsets are created by considering the minimum SNR boundaries of QAM levels for a given target BER. We demonstrate how these schemes can significantly reduce the computational complexity required for power allocation, particularly in the case of a large number of subchannels. Two of the proposed algorithms can achieve near optimal performance including a transfer of residual power between subsets at the expense of a very small extra cost. By simulations, we show that the two near optimal schemes, while greatly reducing complexity, perform best in two separate and distinct SNR regions.

  17. Suboptimal Greedy Power Allocation Schemes for Discrete Bit Loading

    PubMed Central

    2013-01-01

    We consider low cost discrete bit loading based on greedy power allocation (GPA) under the constraints of total transmit power budget, target BER, and maximum permissible QAM modulation order. Compared to the standard GPA, which is optimal in terms of maximising the data throughput, three suboptimal schemes are proposed, which perform GPA on subsets of subchannels only. These subsets are created by considering the minimum SNR boundaries of QAM levels for a given target BER. We demonstrate how these schemes can significantly reduce the computational complexity required for power allocation, particularly in the case of a large number of subchannels. Two of the proposed algorithms can achieve near optimal performance including a transfer of residual power between subsets at the expense of a very small extra cost. By simulations, we show that the two near optimal schemes, while greatly reducing complexity, perform best in two separate and distinct SNR regions. PMID:24501578

  18. Suboptimal Criterion Learning in Static and Dynamic Environments

    PubMed Central

    Fleming, Stephen M.; Daw, Nathaniel D.

    2017-01-01

    Humans often make decisions based on uncertain sensory information. Signal detection theory (SDT) describes detection and discrimination decisions as a comparison of stimulus “strength” to a fixed decision criterion. However, recent research suggests that current responses depend on the recent history of stimuli and previous responses, suggesting that the decision criterion is updated trial-by-trial. The mechanisms underpinning criterion setting remain unknown. Here, we examine how observers learn to set a decision criterion in an orientation-discrimination task under both static and dynamic conditions. To investigate mechanisms underlying trial-by-trial criterion placement, we introduce a novel task in which participants explicitly set the criterion, and compare it to a more traditional discrimination task, allowing us to model this explicit indication of criterion dynamics. In each task, stimuli were ellipses with principal orientations drawn from two categories: Gaussian distributions with different means and equal variance. In the covert-criterion task, observers categorized a displayed ellipse. In the overt-criterion task, observers adjusted the orientation of a line that served as the discrimination criterion for a subsequently presented ellipse. We compared performance to the ideal Bayesian learner and several suboptimal models that varied in both computational and memory demands. Under static and dynamic conditions, we found that, in both tasks, observers used suboptimal learning rules. In most conditions, a model in which the recent history of past samples determines a belief about category means fit the data best for most observers and on average. Our results reveal dynamic adjustment of discrimination criterion, even after prolonged training, and indicate how decision criteria are updated over time. PMID:28046006

  19. The Coming of Knowledge-Based Business.

    ERIC Educational Resources Information Center

    Davis, Stan; Botkin, Jim

    1994-01-01

    Economic growth will come from knowledge-based businesses whose "smart" products filter and interpret information. Businesses will come to think of themselves as educators and their customers as learners. (SK)

  20. Adaptive suboptimal second-order sliding mode control for microgrids

    NASA Astrophysics Data System (ADS)

    Incremona, Gian Paolo; Cucuzzella, Michele; Ferrara, Antonella

    2016-09-01

    This paper deals with the design of adaptive suboptimal second-order sliding mode (ASSOSM) control laws for grid-connected microgrids. Due to the presence of the inverter, of unpredicted load changes, of switching among different renewable energy sources, and of electrical parameters variations, the microgrid model is usually affected by uncertain terms which are bounded, but with unknown upper bounds. To theoretically frame the control problem, the class of second-order systems in Brunovsky canonical form, characterised by the presence of matched uncertain terms with unknown bounds, is first considered. Four adaptive strategies are designed, analysed and compared to select the most effective ones to be applied to the microgrid case study. In the first two strategies, the control amplitude is continuously adjusted, so as to arrive at dominating the effect of the uncertainty on the controlled system. When a suitable control amplitude is attained, the origin of the state space of the auxiliary system becomes attractive. In the other two strategies, a suitable blend between two components, one mainly working during the reaching phase, the other being the predominant one in a vicinity of the sliding manifold, is generated, so as to reduce the control amplitude in steady state. The microgrid system in a grid-connected operation mode, controlled via the selected ASSOSM control strategies, exhibits appreciable stability properties, as proved theoretically and shown in simulation.

  1. Suboptimal health: a new health dimension for translational medicine

    PubMed Central

    2012-01-01

    Background One critical premise of disease-related biomarkers is the definition of the counterpart normality. Contrary to pre-clinical models that can be carefully tailored according to scientific need, heterogeneity and uncontrollability is the essence of humans in health studies. Fully characterization of consistent parameters that define the normal population is the basis to individual differences normalization irrelevant to a given disease process. Self claimed normal status may not represent health because asymptomatic subjects may carry chronic diseases or diseases at their early stage such as cancer, diabetes and hypertension. Methods This paper exemplifies the characterization of the suboptimal health status (SHS) which represents a new public health problem in a population with ambiguous health complaints such as general weakness, unexplained medical syndrome and chronic fatigue. We applied clinical informatics approaches and developed a questionnaire for measuring SHS. The validity and reliability of this approach were evaluated in a small pilot study and then in a cross-sectional study of 3,405 individuals. Results The final questionnaire congregated into a score (SHSQ-25) which could significantly distinguish among several abnormal conditions. Conclusion SHSQ-25 could be used as a translational medicine instrument for health measuring in the general population. PMID:23369267

  2. Optimal web investment in sub-optimal foraging conditions

    NASA Astrophysics Data System (ADS)

    Harmer, Aaron M. T.; Kokko, Hanna; Herberstein, Marie E.; Madin, Joshua S.

    2012-01-01

    Orb web spiders sit at the centre of their approximately circular webs when waiting for prey and so face many of the same challenges as central-place foragers. Prey value decreases with distance from the hub as a function of prey escape time. The further from the hub that prey are intercepted, the longer it takes a spider to reach them and the greater chance they have of escaping. Several species of orb web spiders build vertically elongated ladder-like orb webs against tree trunks, rather than circular orb webs in the open. As ladder web spiders invest disproportionately more web area further from the hub, it is expected they will experience reduced prey gain per unit area of web investment compared to spiders that build circular webs. We developed a model to investigate how building webs in the space-limited microhabitat on tree trunks influences the optimal size, shape and net prey gain of arboricolous ladder webs. The model suggests that as horizontal space becomes more limited, optimal web shape becomes more elongated, and optimal web area decreases. This change in web geometry results in decreased net prey gain compared to webs built without space constraints. However, when space is limited, spiders can achieve higher net prey gain compared to building typical circular webs in the same limited space. Our model shows how spiders optimise web investment in sub-optimal conditions and can be used to understand foraging investment trade-offs in other central-place foragers faced with constrained foraging arenas.

  3. Suboptimal use of non-vitamin K antagonist oral anticoagulants

    PubMed Central

    Başaran, Özcan; Dogan, Volkan; Beton, Osman; Tekinalp, Mehmet; Aykan, Ahmet Cağri; Kalaycioğlu, Ezgi; Bolat, Ismail; Taşar, Onur; Şafak, Özgen; Kalcik, Macit; Yaman, Mehmet; İnci, Sinan; Altintaş, Bernas; Kalkan, Sedat; Kirma, Cevat; Biteker, Murat

    2016-01-01

    Abstract This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians’ adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study). RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression. Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included >65 years of age, creatinine clearance ≥50 mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of <3, whereas that of OT were creatinine clearance <50 mL/min, ongoing rivaroxaban treatment, and HAS-BLED score of ≥3. The suboptimal use of NOACs is common because of physicians’ poor compliance to the guideline recommendations in patients with nonvalvular atrial fibrillation (NVAF). Older patients who were on dabigatran treatment with good renal functions and low risk of bleeding were at risk of UT, whereas patients who were on rivaroxaban treatment with renal impairment and high risk of bleeding were at risk of OT. Therefore, a greater emphasis should be given to prescribe the recommended dose for the specified patients. PMID:27583892

  4. The University-Business Nexus in Australia. Go8 Backgrounder 26

    ERIC Educational Resources Information Center

    Group of Eight (NJ1), 2012

    2012-01-01

    An effective innovation system requires productive interactions between all its parts. Within Australia there is a view that business-university interactions are suboptimal. Government has set a target for doubling the interactions between business and publicly funded researchers by 2020; and the Group of Eight has a strategic priority to build…

  5. Suggestions on how to make suboptimal kidney transplantation an ethically viable option

    PubMed Central

    Graziano, Vincenzo; Buccelli, Claudio; De Micco, Francesco; Casella, Claudia; Di Lorenzo, Pierpaolo; Paternoster, Mariano

    2016-01-01

    Abstract To overcome kidney donation, the pool of potentially eligible donors has been widened by using suboptimal organs harvested from living donors or cadavers. These organs may engender health complications as age, risk factors, and pathologies of donors fail to meet the standard donor criteria. After examining a wide array of literature on suboptimal kidney transplants, we evidenced two major issues: the lack of standardized terminology and the lack of longterm data on the health outcomes of both suboptimal living donors and recipients. Consequently, surgeons are still unable to provide patients with thorough information to obtain a well-informed consent. Suboptimal kidney transplantation still remains in its experimental stage, thereby raising many ethical and medico-legal concerns. We suggest that one possible solution to overcome some of the ethical shortcomings of suboptimal kidney donations is to provide living donors and recipients honest, accurate, and thorough information about its health risks. To this aim, we advocate adopting a widely standardized terminology that would embrace the whole concept of suboptimal kidney transplantation, increasing the number of future publications on the health outcomes of living donors and recipients, spurring ethical reflection to improve the experience of suboptimal kidney transplantation and reduce the waiting-list for kidney transplantation. PMID:28352845

  6. Suboptimal cytoreduction in ovarian carcinoma is associated with molecular pathways characteristic of increased stromal activation

    PubMed Central

    Liu, Zhenqiu; Beach, Jessica A.; Agadjanian, Hasmik; Jia, Dongyu; Aspuria, Paul-Joseph; Karlan, Beth Y.; Orsulic, Sandra

    2015-01-01

    Objective Suboptimal cytoreductive surgery in advanced epithelial ovarian cancer (EOC) is associated with poor survival but it is unknown if poor outcome is due to the intrinsic biology of unresectable tumors or insufficient surgical effort resulting in residual tumor-sustaining clones. Our objective was to identify the potential molecular pathway(s) and cell type(s) that may be responsible for suboptimal surgical resection. Methods By comparing gene expression in optimally and suboptimally cytoreduced patients, we identified a gene network associated with suboptimal cytoreduction and explored the biological processes and cell types associated with this gene network. Results We show that primary tumors from suboptimally cytoreduced patients express molecular signatures that are typically present in a distinct molecular subtype of EOC characterized by increased stromal activation and lymphovascular invasion. Similar molecular pathways are present in EOC metastases, suggesting that primary tumors in suboptimally cytoreduced patients are biologically similar to metastatic tumors. We demonstrate that the suboptimal cytoreduction network genes are enriched in reactive tumor stroma cells rather than malignant tumor cells. Conclusion Our data suggest that the success of cytoreductive surgery is dictated by tumor biology, such as extensive stromal reaction and increased invasiveness, which may hinder surgical resection and ultimately lead to poor survival. PMID:26348314

  7. Interpreting Idioms.

    ERIC Educational Resources Information Center

    Kemper, Susan; Estill, Robert

    A study investigated the immediate comprehension processes involved in the interpretation of English idiomatic expressions. Idioms such as "bury the hatchet" were presented to 48 college students in sentential contexts that either biased the subject toward a literal or a figurative interpretation or left the interpretation ambiguous. In control…

  8. Suboptimal stochastic controller for an n-body spacecraft

    NASA Technical Reports Server (NTRS)

    Larson, V.

    1973-01-01

    The problem is studied of determining a stochastic optimal controller for an n-body spacecraft. The approach used in obtaining the stochastic controller involves the application, interpretation, and combination of advanced dynamical principles and the theoretical aspects of modern control theory. The stochastic controller obtained for a complicated model of a spacecraft uses sensor angular measurements associated with the base body to obtain smoothed estimates of the entire state vector, can be easily implemented, and enables system performance to be significantly improved.

  9. Suboptimal response in chronic myeloid leukemia patients treated with imatinib: early identification and new therapeutic challenges.

    PubMed

    Breccia, Massimo; Alimena, Giuliana

    2012-12-01

    In 2006 European LeukemiaNet proposed recommendations to define several categories of chronic myeloid leukemia patients treated front-line with imatinib. In 2009 an update of these recommendations was published: whereas it is clear how important is to switch rapidly to a second line of treatment in failure patients, the correct treatment of patients with sub-optimal response is still a matter of debate. Several groups have indeed shown that prognosis of patients with sub-optimal cytogenetic response is similar to that of failure patients, whereas lack of data exists for patients with sub-optimal molecular response at 18 months. In this article, we overview studies demonstrating prognostic implications of being suboptimal responders to imatinib as well as results of recent clinical trials testing new generation tyrosine kinase inhibitors in this setting.

  10. Fishy Business.

    ERIC Educational Resources Information Center

    McNamee, Mike

    1988-01-01

    The IRS argues that income from alumni associations group life and medical insurance policies is business profit, not tax-exempt contributions to its member associations. The unrelated business income tax (UBIT) is described. (MLW)

  11. Business Center

    EPA Pesticide Factsheets

    Learn how to do business with EPA's Clean Air Markets, including registering to use the Emissions Collection and Monitoring Plan System (ECMPS), the CAMD Business System (CBS), and learn how to submit monitored emissions data.

  12. E-Business: The Business Officer's Business.

    ERIC Educational Resources Information Center

    Olson, Mark A.

    2001-01-01

    Contends e-business is particularly the domain of college and university business officers, with today's officers facing an unprecedented opportunity to exercise a critical leadership role in the deployment of advanced information technology solutions on campus. Describes relevant issues and advances, and presents ten initiatives that business…

  13. Frequency and predictors of suboptimal glycemic control in an African diabetic population

    PubMed Central

    Kibirige, Davis; Akabwai, George Patrick; Kampiire, Leaticia; Kiggundu, Daniel Ssekikubo; Lumu, William

    2017-01-01

    Background Persistent suboptimal glycemic control is invariably associated with onset and progression of acute and chronic diabetic complications in diabetic patients. In Uganda, studies documenting the magnitude and predictors of suboptimal glycemic control in adult ambulatory diabetic patients are limited. This study aimed at determining the frequency and predictors of suboptimal glycemic control in adult diabetic patients attending three urban outpatient diabetic clinics in Uganda. Methods In this hospital-based cross-sectional study, eligible ambulatory adult diabetic patients attending outpatient diabetic clinics of three urban hospitals were consecutively enrolled over 11 months. Suboptimal glycemic control was defined as glycated hemoglobin (HbA1c) level ≥7%. Multivariable analysis was applied to determine the predictors. Results The mean age of the study participants was 52.2±14.4 years, and the majority of them were females (283, 66.9%). The median (interquartile range) HbA1c level was 9% (6.8%–12.4%). Suboptimal glycemic control was noted in 311 study participants, accounting for 73.52% of the participants. HbA1c levels of 7%–8%, 8.1%–9.9%, and ≥10% were noted in 56 (13.24%), 76 (17.97%), and 179 (42.32%) study participants, respectively. The documented predictors of suboptimal glycemic control were metformin monotherapy (odds ratio: 0.36, 95% confidence interval: 0.21–0.63, p<0.005) and insulin therapy (odds ratio: 2.41, 95% confidence interval: 1.41–4.12, p=0.001). Conclusion Suboptimal glycemic control was highly prevalent in this study population with an association to metformin monotherapy and insulin therapy. Strategies aimed at improving glycemic control in diabetes care in Uganda should be enhanced. PMID:28260942

  14. Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy

    PubMed Central

    Govani, Shail M; Elliott, Eric E; Menees, Stacy B; Judd, Stephanie L; Saini, Sameer D; Anastassiades, Constantinos P; Urganus, Annette L; Boyce, Suzanna J; Schoenfeld, Philip S

    2016-01-01

    AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy. METHODS Retrospective review of the University of Michigan and Veteran’s Administration (VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation. RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation (95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants (TCA) use, diabetes, prep type, site (VA vs non-VA), and presence of a gastroenterology (GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio (OR) = 2.3; 95%CI: 1.6-3.2], TCA use (OR = 2.5; 95%CI: 1.3-4.9), narcotic use (OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350 (OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. PMID:27668072

  15. Interpretive Experiments

    ERIC Educational Resources Information Center

    DeHaan, Frank, Ed.

    1977-01-01

    Describes an interpretative experiment involving the application of symmetry and temperature-dependent proton and fluorine nmr spectroscopy to the solution of structural and kinetic problems in coordination chemistry. (MLH)

  16. Interpreting Bones.

    ERIC Educational Resources Information Center

    Weymouth, Patricia P.

    1986-01-01

    Describes an activity which introduces students to the nature and challenges of paleoanthropology. In the exercise, students identify diagrammed bones and make interpretations about the creature. Presents questions and tasks employed in the lesson. (ML)

  17. Prevalence and Determinants of Suboptimal Vitamin D Levels in a Multiethnic Asian Population.

    PubMed

    Man, Ryan Eyn Kidd; Li, Ling-Jun; Cheng, Ching-Yu; Wong, Tien Yin; Lamoureux, Ecosse; Sabanayagam, Charumathi

    2017-03-22

    This population-based cross-sectional study examined the prevalence and risk factors of suboptimal vitamin D levels (assessed using circulating 25-hydroxycholecalciferol (25(OH)D)) in a multi-ethnic sample of Asian adults. Plasma 25(OH)D concentration of 1139 Chinese, Malay and Indians (40-80 years) were stratified into normal (≥30 ng/mL), and suboptimal (including insufficiency and deficiency, <30 ng/mL) based on the 2011 Endocrine Society Clinical Practice Guidelines. Logistic regression models were used to assess the associations of demographic, lifestyle and clinical risk factors with the outcome. Of the 1139 participants, 25(OH)D concentration was suboptimal in 76.1%. In multivariable models, age ≤65 years (compared to age >65 years), Malay and Indian ethnicities (compared to Chinese ethnicity), and higher body mass index, HbA1c, education and income levels were associated with suboptimal 25(OH)D concentration (p < 0.05). In a population-based sample of Asian adults, approximately 75% had suboptimal 25(OH)D concentration. Targeted interventions and stricter reinforcements of existing guidelines for vitamin D supplementation are needed for groups at risk of vitamin D insufficiency/deficiency.

  18. Suboptimal treatment adherence in bipolar disorder: impact on clinical outcomes and functioning

    PubMed Central

    Montes, Jose Manuel; Maurino, Jorge; de Dios, Consuelo; Medina, Esteban

    2013-01-01

    Background The primary aim of this study was to assess drug treatment adherence in patients with bipolar disorder and to identify factors associated with adherence. The secondary aim was to analyze the impact of suboptimal adherence on clinical and functional outcomes. Methods A cross-sectional study was conducted in a sample of outpatients receiving an oral antipsychotic drug. Medication adherence was assessed combining the 10-item Drug Attitude Inventory, the Morisky Green Adherence Questionnaire, and the Compliance Rating Scale. Logistic regression was used to determine significant variables associated with suboptimal adherence to medication. Results Three hundred and three patients were enrolled into the study. The mean age was 45.9 ± 12.8 years, and 59.7% were females. Sixty-nine percent of patients showed suboptimal adherence. Disease severity and functioning were significantly worse in the suboptimal group than in the adherent group. Multivariate analysis showed depressive polarity of the last acute episode, presence of subsyndromal symptoms, and substance abuse/dependence to be significantly associated with suboptimal treatment adherence (odds ratios 3.41, 2.13, and 1.95, respectively). Conclusion A high prevalence of nonadherence was found in an outpatient sample with bipolar disorder. Identification of factors related to treatment adherence would give clinicians the opportunity to select more adequately patients who are eligible for potential adherence-focused interventions. PMID:23378745

  19. Prevalence and Determinants of Suboptimal Vitamin D Levels in a Multiethnic Asian Population

    PubMed Central

    Man, Ryan Eyn Kidd; Li, Ling-Jun; Cheng, Ching-Yu; Wong, Tien Yin; Lamoureux, Ecosse; Sabanayagam, Charumathi

    2017-01-01

    This population-based cross-sectional study examined the prevalence and risk factors of suboptimal vitamin D levels (assessed using circulating 25-hydroxycholecalciferol (25(OH)D)) in a multi-ethnic sample of Asian adults. Plasma 25(OH)D concentration of 1139 Chinese, Malay and Indians (40–80 years) were stratified into normal (≥30 ng/mL), and suboptimal (including insufficiency and deficiency, <30 ng/mL) based on the 2011 Endocrine Society Clinical Practice Guidelines. Logistic regression models were used to assess the associations of demographic, lifestyle and clinical risk factors with the outcome. Of the 1139 participants, 25(OH)D concentration was suboptimal in 76.1%. In multivariable models, age ≤65 years (compared to age >65 years), Malay and Indian ethnicities (compared to Chinese ethnicity), and higher body mass index, HbA1c, education and income levels were associated with suboptimal 25(OH)D concentration (p < 0.05). In a population-based sample of Asian adults, approximately 75% had suboptimal 25(OH)D concentration. Targeted interventions and stricter reinforcements of existing guidelines for vitamin D supplementation are needed for groups at risk of vitamin D insufficiency/deficiency. PMID:28327512

  20. Environmental Enrichment Affects Suboptimal, Risky, Gambling-Like Choice by Pigeons

    PubMed Central

    Pattison, Kristina F.; Laude, Jennifer R.; Zentall, Thomas R.

    2013-01-01

    Pigeons prefer a risky option with a low probability of a high payoff over a less risky option that results in more food. This finding is analogous to suboptimal human monetary gambling because in both cases there appears to be an overemphasis of the occurrence of the winning event and an underemphasis of the losing event. In the present research we found that pigeons that were exposed to an enriched environment (a large cage with three other pigeons for 4 hrs a day) were less likely to show this suboptimal choice behavior compared with typically housed laboratory pigeons in a control group. These results have implications for the mechanisms underlying suboptimal choice by humans (e.g., problem gamblers) and they suggest that a enriched environment may allow for enhanced self-control. PMID:23224431

  1. Interpreting Evidence.

    ERIC Educational Resources Information Center

    Munsart, Craig A.

    1993-01-01

    Presents an activity that allows students to experience the type of discovery process that paleontologists necessarily followed during the early dinosaur explorations. Students are read parts of a story taken from the "American Journal of Science" and interpret the evidence leading to the discovery of Triceratops and Stegosaurus. (PR)

  2. Performing Interpretation

    ERIC Educational Resources Information Center

    Kothe, Elsa Lenz; Berard, Marie-France

    2013-01-01

    Utilizing a/r/tographic methodology to interrogate interpretive acts in museums, multiple areas of inquiry are raised in this paper, including: which knowledge is assigned the greatest value when preparing a gallery talk; what lies outside of disciplinary knowledge; how invitations to participate invite and disinvite in the same gesture; and what…

  3. Interpreting Metonymy.

    ERIC Educational Resources Information Center

    Pankhurst, Anne

    1994-01-01

    This paper examines some of the problems associated with interpreting metonymy, a figure of speech in which an attribute or commonly associated feature is used to name or designate something. After defining metonymy and outlining the principles of metonymy, the paper explains the differences between metonymy, synecdoche, and metaphor. It is…

  4. Business Writing.

    ERIC Educational Resources Information Center

    Burt, Lorna; Lewandowski, Carol

    This workbook, designed for workplace literacy courses, contains materials for a business writing course. The course presents the fundamentals of effective business letter writing, focusing on logical organization, word choice, style, tone, and clarity. The course uses students' own examples as well as practice exercises for reinforcement.…

  5. Business & Operations

    ERIC Educational Resources Information Center

    Agron, Joe

    2007-01-01

    This article presents an interview with John D. Musso, executive director of the Association of School Business Officials (ASBO) International. Musso talks about trends and issues that will most affect school business and operations in 2007 and beyond. Despite the challenges facing school operations, he believes that the key to being successful at…

  6. Central suboptimal H ∞ controller design for linear time-varying systems with unknown parameters

    NASA Astrophysics Data System (ADS)

    Basin, Michael V.; Soto, Pedro; Calderon-Alvarez, Dario

    2011-05-01

    This article presents the central finite-dimensional H ∞ controller for linear time-varying systems with unknown parameters, that is suboptimal for a given threshold γ with respect to a modified Bolza-Meyer quadratic criterion including the attenuation control term with the opposite sign. In contrast to the previously obtained results, this article reduces the original H ∞ controller problem to the corresponding H 2 controller problem, using the technique proposed in Doyle et al. [Doyle, J.C., Glover, K., Khargonekar, P.P., and Francis, B.A. (1989), 'State-space Solutions to Standard H 2 and H Infinity Control Problems', IEEE Transactions Automatic Control, 34, 831-847]. This article yields the central suboptimal H ∞ controller for linear systems with unknown parameters in a closed finite-dimensional form, based on the corresponding H 2 controller obtained in Basin and Calderon-Alvarez [Basin, M.V., and Calderon-Alvarez, D. (2008), 'Optimal LQG Controller for Linear Systems with Unknown Parameters', Journal of The Franklin Institute, 345, 293-302]. Numerical simulations are conducted to verify performance of the designed central suboptimal controller for uncertain linear systems with unknown parameters against the conventional central suboptimal H ∞ controller for linear systems with exactly known parameter values.

  7. The incidence of sub-optimal sedation in the ICU: a systematic review

    PubMed Central

    2009-01-01

    Introduction Patients in intensive care units (ICUs) are generally sedated for prolonged periods. Over-sedation and under-sedation both have negative effects on patient safety and resource use. We conducted a systematic review of the literature in order to establish the incidence of sub-optimal sedation (both over- and under-sedation) in ICUs. Methods We searched Medline, Embase and CINAHL (Cumulative Index to Nursing and Allied Health Literature) online literature databases from 1988 to 15 May 2008 and hand-searched conferences. English-language studies set in the ICU, in sedated adult humans on mechanical ventilation, which reported the incidence of sub-optimal sedation, were included. All abstracts were reviewed twice by two independent reviewers, with all conflicts resolved by a third reviewer, to check that they met the review inclusion criteria. Full papers of all included studies were retrieved and were again reviewed twice against inclusion criteria. Data were doubly extracted. Study aims, design, population, comparisons made, and data on the incidence of sub-optimal, optimal, over-sedation or under-sedation were extracted. Results There was considerable variation between included studies in the definition of optimal sedation and in the scale or method used to assess sedation. Across all included studies, a substantial incidence of sub-optimal sedation was reported, with a greater tendency toward over-sedation. Conclusions Our review suggests that improvements in the consistent definition and measurement of sedation may improve the quality of care of patients within the ICU. PMID:20015357

  8. Statin therapy reduces the likelihood of suboptimal blood pressure control among Ugandan adult diabetic patients

    PubMed Central

    Lumu, William; Kampiire, Leaticia; Akabwai, George Patrick; Kiggundu, Daniel Ssekikubo; Kibirige, Davis

    2017-01-01

    Background Hypertension is one of the recognized risk factors of cardiovascular diseases in adult diabetic patients. High prevalence of suboptimal blood pressure (BP) control has been well documented in the majority of studies assessing BP control in diabetic patients in sub-Saharan Africa. In Uganda, there is a dearth of similar studies. This study evaluated the prevalence and correlates of suboptimal BP control in an adult diabetic population in Uganda. Patients and methods This was a cross-sectional study that enrolled 425 eligible ambulatory adult diabetic patients attending three urban diabetic outpatient clinics over 11 months. Data about their sociodemographic characteristics and clinical history were collected using pre-tested questionnaires. Suboptimal BP control was defined according to the 2015 American Diabetes Association standards of diabetes care guideline as BP levels ≥140/90 mmHg. Results The mean age of the study participants was 52.2±14.4 years, with the majority being females (283, 66.9%). Suboptimal BP control was documented in 192 (45.3%) study participants and was independently associated with the study site (private hospitals; odds ratio 2.01, 95% confidence interval 1.18–3.43, P=0.01) and use of statin therapy (odds ratio 0.5, 95% confidence interval 0.26–0.96, P=0.037). Conclusion Suboptimal BP control was highly prevalent in this study population. Strategies to improve optimal BP control, especially in the private hospitals, and the use of statin therapy should be encouraged in adult diabetic patients. PMID:28260908

  9. Interpretive Medicine

    PubMed Central

    Reeve, Joanne

    2010-01-01

    Patient-centredness is a core value of general practice; it is defined as the interpersonal processes that support the holistic care of individuals. To date, efforts to demonstrate their relationship to patient outcomes have been disappointing, whilst some studies suggest values may be more rhetoric than reality. Contextual issues influence the quality of patient-centred consultations, impacting on outcomes. The legitimate use of knowledge, or evidence, is a defining aspect of modern practice, and has implications for patient-centredness. Based on a critical review of the literature, on my own empirical research, and on reflections from my clinical practice, I critique current models of the use of knowledge in supporting individualised care. Evidence-Based Medicine (EBM), and its implementation within health policy as Scientific Bureaucratic Medicine (SBM), define best evidence in terms of an epistemological emphasis on scientific knowledge over clinical experience. It provides objective knowledge of disease, including quantitative estimates of the certainty of that knowledge. Whilst arguably appropriate for secondary care, involving episodic care of selected populations referred in for specialist diagnosis and treatment of disease, application to general practice can be questioned given the complex, dynamic and uncertain nature of much of the illness that is treated. I propose that general practice is better described by a model of Interpretive Medicine (IM): the critical, thoughtful, professional use of an appropriate range of knowledges in the dynamic, shared exploration and interpretation of individual illness experience, in order to support the creative capacity of individuals in maintaining their daily lives. Whilst the generation of interpreted knowledge is an essential part of daily general practice, the profession does not have an adequate framework by which this activity can be externally judged to have been done well. Drawing on theory related to the

  10. Building Businesses.

    ERIC Educational Resources Information Center

    Sturgeon, Julie

    2000-01-01

    Discusses how Washington University (St. Louis, MO) converted odd space into a program allowing students to be shopkeepers for necessary services and the school assuming the role of landlord. Tips for overseeing student businesses are highlighted. (GR)

  11. Suboptimal LQR-based spacecraft full motion control: Theory and experimentation

    NASA Astrophysics Data System (ADS)

    Guarnaccia, Leone; Bevilacqua, Riccardo; Pastorelli, Stefano P.

    2016-05-01

    This work introduces a real time suboptimal control algorithm for six-degree-of-freedom spacecraft maneuvering based on a State-Dependent-Algebraic-Riccati-Equation (SDARE) approach and real-time linearization of the equations of motion. The control strategy is sub-optimal since the gains of the linear quadratic regulator (LQR) are re-computed at each sample time. The cost function of the proposed controller has been compared with the one obtained via a general purpose optimal control software, showing, on average, an increase in control effort of approximately 15%, compensated by real-time implementability. Lastly, the paper presents experimental tests on a hardware-in-the-loop six-degree-of-freedom spacecraft simulator, designed for testing new guidance, navigation, and control algorithms for nano-satellites in a one-g laboratory environment. The tests show the real-time feasibility of the proposed approach.

  12. Peptide Suboptimal Conformation Sampling for the Prediction of Protein-Peptide Interactions.

    PubMed

    Lamiable, Alexis; Thévenet, Pierre; Eustache, Stephanie; Saladin, Adrien; Moroy, Gautier; Tuffery, Pierre

    2017-01-01

    The blind identification of candidate patches of interaction on the protein surface is a difficult task that can hardly be accomplished without a heuristic or the use of simplified representations to speed up the search. The PEP-SiteFinder protocol performs a systematic blind search on the protein surface using a rigid docking procedure applied to a limited set of peptide suboptimal conformations expected to approximate satisfactorily the conformation of the peptide in interaction. All steps rely on a coarse-grained representation of the protein and the peptide. While simple, such a protocol can help to infer useful information, assuming a critical analysis of the results. Moreover, such a protocol can be extended to a semi-flexible protocol where the suboptimal conformations are directly folded in the vicinity of the receptor.

  13. Neyman-Pearson Optimal and Suboptimal Detection for Signals in General Clutter Mixture Distributions

    DTIC Science & Technology

    2011-03-01

    UNCLASSIFIED Neyman -Pearson Optimal and Suboptimal Detection for Signals in General Clutter Mixture Distributions Graham V. Weinberg Electronic...construction of the Neyman - Pearson optimal detector for a single general target model embedded within complex clutter whose amplitude distribution forms a...Commonwealth of Australia 2011 AR No. AR-014-933 March 2011 APPROVED FOR PUBLIC RELEASE ii UNCLASSIFIED UNCLASSIFIED DSTO–RR–0363 Neyman -Pearson

  14. Suboptimal choice in rats: Incentive salience attribution promotes maladaptive decision-making.

    PubMed

    Chow, Jonathan J; Smith, Aaron P; Wilson, A George; Zentall, Thomas R; Beckmann, Joshua S

    2017-03-01

    Stimuli that are more predictive of subsequent reward also function as better conditioned reinforcers. Moreover, stimuli attributed with incentive salience function as more robust conditioned reinforcers. Some theories have suggested that conditioned reinforcement plays an important role in promoting suboptimal choice behavior, like gambling. The present experiments examined how different stimuli, those attributed with incentive salience versus those without, can function in tandem with stimulus-reward predictive utility to promote maladaptive decision-making in rats. One group of rats had lights associated with goal-tracking as the reward-predictive stimuli and another had levers associated with sign-tracking as the reward-predictive stimuli. All rats were first trained on a choice procedure in which the expected value across both alternatives was equivalent but differed in their stimulus-reward predictive utility. Next, the expected value across both alternatives was systematically changed so that the alternative with greater stimulus-reward predictive utility was suboptimal in regard to primary reinforcement. The results demonstrate that in order to obtain suboptimal choice behavior, incentive salience alongside strong stimulus-reward predictive utility may be necessary; thus, maladaptive decision-making can be driven more by the value attributed to stimuli imbued with incentive salience that reliably predict a reward rather than the reward itself.

  15. Preoperative Lymphocyte-Monocyte Ratio Is a Predictor of Suboptimal Cytoreduction in Stage III-IV Epithelial Ovarian Cancer

    PubMed Central

    Eo, Wankyu; Kim, Hong-Bae; Lee, Yong Joo; Suh, Dong Soo; Kim, Ki Hyung; Kim, Heungyeol

    2016-01-01

    Objective: To determine whether the preoperative lymphocyte-monocyte ratio (LMR) is a predictor of suboptimal cytoreduction in advanced-stage epithelial ovarian cancer (EOC). Methods: Preoperative clinico-pathologic and hematologic parameters were reviewed in a total of 154 patients with EOC submitted to primary cytoreductive surgery. Patients were categorized into two different groups according to the results of cytoreductive surgery: optimal and suboptimal cytoreduction. Continuous variables were categorized into two groups using the best cutoff points selected on the receiver operating characteristic (ROC) curve for suboptimal cytoreduction. Results: Based on data collected from the 154 patients, 133 (86.4%) and 21 (13.6%) patients presented with stage III and IV disease, respectively. One hundred seventeen (76.0%) patients had serous adenocarcinoma, and 92 (59.7%) had histologic tumor grade 3. The optimal and suboptimal cytoreduction groups included 96 (62.3%) and 58 patients (37.7%), respectively. The best LMR cutoff point for suboptimal cytoreduction was 3.75. On multivariate logistic regression analysis, age, cancer antigen 125, white blood cell count, and LMR were found to be the strongest predictors for suboptimal cytoreduction (P=0.0037, 0.0249, 0.0062, and 0.0015, respectively). Conclusion: Preoperative LMR is an independent predictor of suboptimal cytoreduction. It provides additional prognostic information beyond the biological parameters of the tumor. PMID:27698915

  16. Patients' characteristics and clinical implications of suboptimal CD4 T-cell gains after 1 year of successful antiretroviral therapy.

    PubMed

    Gutiérrez, Félix; Padilla, Sergio; Masiá, Mar; Iribarren, José A; Moreno, Santiago; Viciana, Pompeyo; Hernández-Quero, José; Alemán, Remedios; Vidal, Francesc; Salavert, Miguel; Blanco, José R; Leal, Manuel; Dronda, Fernando; Perez Hoyos, Santiago; del Amo, Julia

    2008-03-01

    To describe characteristics and prognosis of patients with suboptimal immunological response to combined antiretroviral therapy (CART). Using data from a multicenter cohort study, we selected patients who initiated CART and showed suboptimal CD4-T cell response (defined as <50 cells/L increase) after 1 year of therapy, despite sustained virological suppression. Characteristics of those patients were compared with subjects who showed optimal immunological response. Of 650 patients with virological suppression, 108 (16.6%) showed suboptimal CD4-T cell response. Independent predictors of suboptimal response were previous injection drug use (OR, 1.85; 95% CI, 1.12-2.98) and age at CART initiation (OR, 1.04 per year increase; 95%CI, 1.01-1.06). Hepatitis C virus coinfection was not associated with impaired immunological response. As compared with patients with optimal immunological response, those with suboptimal response had a higher mortality rate (3.22 versus 0.71 per 100 person-years; p=.001), but a similar rate of new AIDS-defining events. In patients with sustained virological suppression with CART, previous injection drug use, but not hepatitis C virus coinfection, and older age at initiation of therapy were associated with suboptimal CD4 T-cell responses. Patients with suboptimal response had a higher mortality over time, mainly due to diseases other than AIDS-defining events.

  17. 12 CFR 194.802 - Description of business.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Description of business. 194.802 Section 194... SAVINGS ASSOCIATIONS Interpretations § 194.802 Description of business. (a) This section applies to the description-of-business portion of: (1) Registration statements filed on Form 10 (item 1) (17 CFR 249.210),...

  18. 12 CFR 563d.802 - Description of business.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Description of business. 563d.802 Section 563d... ASSOCIATIONS Interpretations § 563d.802 Description of business. (a) This section applies to the description-of-business portion of: (1) Registration statements filed on Form 10 (item 1) (17 CFR 249.210), (2) Proxy...

  19. 12 CFR 225.112 - Indirect control of small business concern through convertible debentures held by small business...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Indirect control of small business concern through convertible debentures held by small business investment company. 225.112 Section 225.112 Banks... Interpretations § 225.112 Indirect control of small business concern through convertible debentures held by...

  20. Business Graphics

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Genigraphics Corporation's Masterpiece 8770 FilmRecorder is an advanced high resolution system designed to improve and expand a company's in-house graphics production. GRAFTIME/software package was designed to allow office personnel with minimal training to produce professional level graphics for business communications and presentations. Products are no longer being manufactured.

  1. Unfinished Business

    ERIC Educational Resources Information Center

    Tuckett, Alan

    2011-01-01

    Adult learning is not a tidy business: adults fit learning into the spaces left by the other demands on complex lives, and into the spaces left in administrative structures overwhelmingly designed for other people. No simple metric can capture adults' diverse purposes and achievements, and no single programme can capture the full range of things…

  2. Business Computers.

    ERIC Educational Resources Information Center

    Canipe, Stephen L.

    A brief definition of some fundamentals of microcomputers and of the ways they may be used in small businesses can help potential buyers make informed purchases. Hardware (the mechanical devices from which computers are made) described here are the video display, keyboard, central processing unit, "random access" and "read only" memories, cassette…

  3. Strictly Business

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    When Jackson State University opened for classes this year, it marked its fifth anniversary in the online education business by adding a full four-year, undergraduate degree program in early childhood education to its offerings. Jackson State is among a growing number of historically Black colleges tying part of their future survival and growth…

  4. [Effects of chlorophyllin-iron on osmotic adjustment and activities of antioxidantive enzymes in cucumber seedlings under suboptimal temperature].

    PubMed

    Zhang, Meng; Wang, Xiu-feng; Zhang, Fan-yang; Wei, Min; Shi, Qing-hua; Yang, Feng-juan; Li, Yan

    2014-12-01

    Cucumber cultivar 'Jinyan 4' was subjected to suboptimal temperature treatment of 18/12 degrees C (day/night) in the growth chambers. A solution culture experiment was conducted to study the effect of exogenously spraying 5 mg x L(-1) chlorophyllin-iron solution on plant growth, the content of proline, soluble sugar, MDA and activity of peroxidase in the leaves of cucumber seedling under suboptimal temperature. Application of chlorophyllin-iron showed prominent effects on mitigating the stress of suboptimal temperature on growth of the cucumber seedlings, significantly increasing the plant height, leaf area, shoot dry mass, the contents of soluble sugar and proline and the activities of SOD, POD, CAT and APX. Exogenously spraying chlorophyllin-iron could promote the accumulation of proline and soluble sugar, raise the activities of antioxidant enzymes, decrease the membrane lipid peroxidation and improve the adaptability of cucumber seedlings under suboptimal temperature.

  5. On the design of suboptimal sliding manifold for a class of nonlinear uncertain time-delay systems

    NASA Astrophysics Data System (ADS)

    Batmani, Yazdan; Khaloozadeh, Hamid

    2016-08-01

    This paper proposes a new method to design suboptimal sliding manifolds for a class of nonlinear uncertain systems with state and input delays. A switching control law is obtained based on the designed suboptimal sliding manifold. It is proved that the proposed method is able to guarantee the stability of the closed-loop system in the presence of uncertainty. Three numerical simulations are given to illustrate the effectiveness of the proposed method.

  6. Business Ownership and Management.

    ERIC Educational Resources Information Center

    Kaser, Ken, Ed.

    1991-01-01

    Includes five articles: "Women in Management" (Zimmerer); "Business Boot Camp (interviews with young entrepreneurs)" (Kaser); "Plan Your Own Business Project" (Kohns); "Business Education and the Middle Level Student" (Patterson, Leblanc); and "Small Business Ownership Planning" (Fiber). (SK)

  7. Suboptimal temperature favors reserve formation in biennial carrot (Daucus carota) plants.

    PubMed

    González, María V; Sadras, Victor O; Equiza, María A; Tognetti, Jorge A

    2009-09-01

    In response to suboptimal temperatures, temperate annual plants often increase root:shoot ratios, build-up carbohydrates and display typical morphological and anatomical changes. We know less about the responses of biennials such as carrot. As a model plant, carrot has the additional feature of two functionally and morphologically distinct root parts: the taproot, which stores carbohydrate and other compounds, and the fibrous root system involved in acquisition of water and nutrients. Here, we analyze the effects of temperature (12 vs 25°C) on growth, carbohydrate accumulation and whole-plant morphology in two carrot cultivars. Our working hypothesis is that suboptimal temperature favors active formation of reserve structures, rather than passive accumulation of storage carbohydrates. In comparison with plants grown at 25°C, plants grown at 12°C had: (1) higher fibrous root:shoot ratio (13%) , (2) thicker (10-15%) and smaller (up to two- to three-fold) leaves, (3) lower leaf cuticular permeance (two- to four-fold), (4) higher taproot:shoot ratio (two-fold), (5) higher phloem:xylem ratios in taproot (two- to six-fold), (6) unchanged percentage dry matter content (%DMC) in leaves, petioles or fibrous roots and (7) higher %DMC in taproot (20%). However, %DMC of individual taproot tissues (phloem and xylem) was unaffected by temperatures and was consistently higher in the phloem (up to 30%). Therefore, the higher %DMC of whole taproots at 12°C was attributed solely to the increased development of phloem tissue. Carrot, therefore, shares many of the most conspicuous elements of temperate plant responses to low temperatures. Consistently with our hypothesis, however, carrots grown at suboptimal temperature promoted reserve structures, rather than the increase in carbohydrate concentration typical of most temperate annual species and woody perennials.

  8. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?12

    PubMed Central

    Rosanoff, Andrea; Dai, Qi; Shapses, Sue A

    2016-01-01

    Although much is known about magnesium, its interactions with calcium and vitamin D are less well studied. Magnesium intake is low in populations who consume modern processed-food diets. Low magnesium intake is associated with chronic diseases of global concern [e.g., cardiovascular disease (CVD), type 2 diabetes, metabolic syndrome, and skeletal disorders], as is low vitamin D status. No simple, reliable biomarker for whole-body magnesium status is currently available, which makes clinical assessment and interpretation of human magnesium research difficult. Between 1977 and 2012, US calcium intakes increased at a rate 2–2.5 times that of magnesium intakes, resulting in a dietary calcium to magnesium intake ratio of >3.0. Calcium to magnesium ratios <1.7 and >2.8 can be detrimental, and optimal ratios may be ∼2.0. Background calcium to magnesium ratios can affect studies of either mineral alone. For example, US studies (background Ca:Mg >3.0) showed benefits of high dietary or supplemental magnesium for CVD, whereas similar Chinese studies (background Ca:Mg <1.7) showed increased risks of CVD. Oral vitamin D is widely recommended in US age-sex groups with low dietary magnesium. Magnesium is a cofactor for vitamin D biosynthesis, transport, and activation; and vitamin D and magnesium studies both showed associations with several of the same chronic diseases. Research on possible magnesium and vitamin D interactions in these human diseases is currently rare. Increasing calcium to magnesium intake ratios, coupled with calcium and vitamin D supplementation coincident with suboptimal magnesium intakes, may have unknown health implications. Interactions of low magnesium status with calcium and vitamin D, especially during supplementation, require further study. PMID:26773013

  9. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?

    PubMed

    Rosanoff, Andrea; Dai, Qi; Shapses, Sue A

    2016-01-01

    Although much is known about magnesium, its interactions with calcium and vitamin D are less well studied. Magnesium intake is low in populations who consume modern processed-food diets. Low magnesium intake is associated with chronic diseases of global concern [e.g., cardiovascular disease (CVD), type 2 diabetes, metabolic syndrome, and skeletal disorders], as is low vitamin D status. No simple, reliable biomarker for whole-body magnesium status is currently available, which makes clinical assessment and interpretation of human magnesium research difficult. Between 1977 and 2012, US calcium intakes increased at a rate 2-2.5 times that of magnesium intakes, resulting in a dietary calcium to magnesium intake ratio of >3.0. Calcium to magnesium ratios <1.7 and >2.8 can be detrimental, and optimal ratios may be ∼2.0. Background calcium to magnesium ratios can affect studies of either mineral alone. For example, US studies (background Ca:Mg >3.0) showed benefits of high dietary or supplemental magnesium for CVD, whereas similar Chinese studies (background Ca:Mg <1.7) showed increased risks of CVD. Oral vitamin D is widely recommended in US age-sex groups with low dietary magnesium. Magnesium is a cofactor for vitamin D biosynthesis, transport, and activation; and vitamin D and magnesium studies both showed associations with several of the same chronic diseases. Research on possible magnesium and vitamin D interactions in these human diseases is currently rare. Increasing calcium to magnesium intake ratios, coupled with calcium and vitamin D supplementation coincident with suboptimal magnesium intakes, may have unknown health implications. Interactions of low magnesium status with calcium and vitamin D, especially during supplementation, require further study.

  10. An analysis of suboptimal outcomes of medial malleolus fractures in skeletally immature children.

    PubMed

    Luhmann, Scott J; Oda, Jon E; O'Donnell, June; Keeler, Kathryn A; Schoenecker, Perry L; Dobbs, Matthew B; Gordon, J Eric

    2012-03-01

    We retrospectively analyzed cases of intra-articular medial malleolar fractures in skeletally-immature patients (Salter-Harris III and IV) with suboptimal outcomes at St. Louis Children's Hospital and Shriner's Hospital for Children. Common causes of poor outcome were frac­ture malunion or malreduction and physeal damage. Malreductions of only 2 mm does not appear to be toler­ated and the concept of "remodeling" does not apply to these fracture patterns. Based on this study, we "recom­mend" fracture reduction and fixation if there is greater than 1 mm of fracture step-off..

  11. Suboptimal filtering of 1/ƒ;-noise in detector charge measurements

    NASA Astrophysics Data System (ADS)

    Gatti, E.; Manfredi, P. F.; Sampietro, M.; Speziali, V.

    1990-12-01

    Processing of {1}/{tf}- noise by suboptimal filters in detector charge measurements is considered. The achievable values of equivalent noise charge are compared to those provided by the optimum filter. Some aspects of filters processing {1}/{tf}- noise, like the degradation in the accuracy of charge measurements due to a bipolar or to a unipolar, flat-topped weighting function are described. Several conclusions are expected to be useful in the design of analog processors for radiation detectors when the front-end {1}/{tf}- noise is not negligible.

  12. Business Jet

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Citation Jet, developed by Cessna Aircraft Company, Wichita, KS, is the first business jet to employ Langley Research Center's natural laminar flow (NLF) technology. NLF reduces drag and therefore saves fuel by using only the shape of the wing to keep the airflow smooth, or laminar. This reduces friction between the air and wing, and therefore, reduces drag. NASA's Central Industrial Applications Center, Rural Enterprises, Inc., Durant, OK, its Kansas affiliate, and Wichita State University assisted in the technology transfer.

  13. Business, Introduction

    NASA Astrophysics Data System (ADS)

    Dupree, Andrea

    1998-05-01

    The annual business meeting, which all members are encouraged to attend, will take place on Tuesday afternoon. Come enjoy the President's Ice Cream Party. Come meet new officers. Come nominate candidates for the Nominating Committee. The Nominating Committee is a very important body which provides the slate of candidates for the annual AAS election. Society business will be discussed briefly. Highlighting this meeting will be a panel discussion on: "How to Get Your Paper Published Promptly" Should I mention that Notable Authority Professor Hjalmar Sciatti hates me and my papers? When is it OK to start complaining that no report has arrived? Do I have to do everything the referee says? These and related questions will be addressed at the business meeting in a panel presentation by the editors of the three main AAS publications, Paul Hodge (AJ), Helmut Abt (ApJ), Alex Dalgarno (ApJ Letters), concerning the refereeing and editing process and how authors can interface with it most effectively. There will be time for questions and discussions toward the end, or you can send your questions in advance to askeds@aas.org, so that the most frequent ones can be covered in the presentations.

  14. A test of stress, cues, and re-exposure to large wins as potential reinstaters of suboptimal decision making in rats

    PubMed Central

    Connolly, Nina P.; Kim, Jung S.; Tunstall, Brendan J.; Kearns, David N.

    2015-01-01

    The present experiment investigated potential reinstaters of suboptimal economic decision making in rats. Rats were first trained on a version of the rat Gambling Task under conditions designed to promote choice of a suboptimal option that occasionally resulted in large “wins” (four sucrose pellets). In a second phase, preference for this economically suboptimal option was reduced by substantially increasing the probability of punishment when this option was chosen. Then, three events were tested for their ability to reinstate choice of the suboptimal option. A brief period of re-exposure to a high frequency of large wins significantly increased choice of the suboptimal option. The pharmacological stressor yohimbine did not reinstate suboptimal choice, but did increase impulsive action as indexed by premature responding. Presentation of cues previously associated with large wins did not alter behavior. Results suggest reinstaters of suboptimal choice may differ from reinstaters of extinguished drug- and food-seeking behavior. PMID:25904885

  15. Gibberellin Is Involved in Inhibition of Cucumber Growth and Nitrogen Uptake at Suboptimal Root-Zone Temperatures

    PubMed Central

    Zhang, Xiaocui; Yu, Xianchang

    2016-01-01

    Suboptimal temperature stress often causes heavy yield losses of vegetables by suppressing plant growth during winter and early spring. Gibberellin acid (GA) has been reported to be involved in plant growth and acquisition of mineral nutrients. However, no studies have evaluated the role of GA in the regulation of growth and nutrient acquisition by vegetables under conditions of suboptimal temperatures in greenhouse. Here, we investigated the roles of GA in the regulation of growth and nitrate acquisition of cucumber (Cucumis sativus L.) plants under conditions of short-term suboptimal root-zone temperatures (Tr). Exposure of cucumber seedlings to a Tr of 16°C led to a significant reduction in root growth, and this inhibitory effect was reversed by exogenous application of GA. Expression patterns of several genes encoding key enzymes in GA metabolism were altered by suboptimal Tr treatment, and endogenous GA concentrations in cucumber roots were significantly reduced by exposure of cucumber plants to 16°C Tr, suggesting that inhibition of root growth by suboptimal Tr may result from disruption of endogenous GA homeostasis. To further explore the mechanism underlying the GA-dependent cucumber growth under suboptimal Tr, we studied the effect of suboptimal Tr and GA on nitrate uptake, and found that exposure of cucumber seedlings to 16°C Tr led to a significant reduction in nitrate uptake rate, and exogenous application GA can alleviate the down-regulation by up regulating the expression of genes associated with nitrate uptake. Finally, we demonstrated that N accumulation in cucumber seedlings under suboptimal Tr conditions was improved by exogenous application of GA due probably to both enhanced root growth and nitrate absorption activity. These results indicate that a reduction in endogenous GA concentrations in roots due to down-regulation of GA biosynthesis at transcriptional level may be a key event to underpin the suboptimal Tr-induced inhibition of root

  16. Gibberellin Is Involved in Inhibition of Cucumber Growth and Nitrogen Uptake at Suboptimal Root-Zone Temperatures.

    PubMed

    Bai, Longqiang; Deng, Huihui; Zhang, Xiaocui; Yu, Xianchang; Li, Yansu

    2016-01-01

    Suboptimal temperature stress often causes heavy yield losses of vegetables by suppressing plant growth during winter and early spring. Gibberellin acid (GA) has been reported to be involved in plant growth and acquisition of mineral nutrients. However, no studies have evaluated the role of GA in the regulation of growth and nutrient acquisition by vegetables under conditions of suboptimal temperatures in greenhouse. Here, we investigated the roles of GA in the regulation of growth and nitrate acquisition of cucumber (Cucumis sativus L.) plants under conditions of short-term suboptimal root-zone temperatures (Tr). Exposure of cucumber seedlings to a Tr of 16°C led to a significant reduction in root growth, and this inhibitory effect was reversed by exogenous application of GA. Expression patterns of several genes encoding key enzymes in GA metabolism were altered by suboptimal Tr treatment, and endogenous GA concentrations in cucumber roots were significantly reduced by exposure of cucumber plants to 16°C Tr, suggesting that inhibition of root growth by suboptimal Tr may result from disruption of endogenous GA homeostasis. To further explore the mechanism underlying the GA-dependent cucumber growth under suboptimal Tr, we studied the effect of suboptimal Tr and GA on nitrate uptake, and found that exposure of cucumber seedlings to 16°C Tr led to a significant reduction in nitrate uptake rate, and exogenous application GA can alleviate the down-regulation by up regulating the expression of genes associated with nitrate uptake. Finally, we demonstrated that N accumulation in cucumber seedlings under suboptimal Tr conditions was improved by exogenous application of GA due probably to both enhanced root growth and nitrate absorption activity. These results indicate that a reduction in endogenous GA concentrations in roots due to down-regulation of GA biosynthesis at transcriptional level may be a key event to underpin the suboptimal Tr-induced inhibition of root

  17. Common experiences of patients following suboptimal treatment outcomes: implications for epilepsy surgery.

    PubMed

    Fernando, Dinusha K; McIntosh, Anne M; Bladin, Peter F; Wilson, Sarah J

    2014-04-01

    Few studies have investigated the patient experience of unsuccessful medical interventions, particularly in the epilepsy surgery field. The present review aimed to gain insight into the patient experience of seizure recurrence after epilepsy surgery by examining the broader literature dealing with suboptimal results after medical interventions (including epilepsy surgery). To capture the patient experience, the literature search focused on qualitative research of patients who had undergone medically unsuccessful interventions, published in English in scholarly journals. Twenty-two studies were found of patients experiencing a range of suboptimal outcomes, including seizure recurrence, cancer recurrence and progression, unsuccessful joint replacement, unsuccessful infertility treatment, organ transplant rejection, coronary bypass graft surgery, and unsuccessful weight-loss surgery. In order of frequency, the most common patient experiences included the following: altered social dynamics and stigma, unmet expectations, negative emotions, use of coping strategies, hope and optimism, perceived failure of the treating team, psychiatric symptoms, and control issues. There is support in the epilepsy surgery literature that unmet expectations and psychiatric symptoms are key issues for patients with seizure recurrence, while other common patient experiences have been implied but not systematically examined. Several epilepsy surgery specific factors influence patient perceptions of seizure recurrence, including the nature of postoperative seizures, the presence of postoperative complications, and the need for increased postoperative medications. Knowledge of common patient experiences can assist in the delivery of patient follow-up and rehabilitation services tailored to differing outcomes after epilepsy surgery.

  18. Suboptimal Larval Habitats Modulate Oviposition of the Malaria Vector Mosquito Anopheles coluzzii

    PubMed Central

    Suh, Eunho; Choe, Dong-Hwan; Saveer, Ahmed M.; Zwiebel, Laurence J.

    2016-01-01

    Selection of oviposition sites by gravid females is a critical behavioral step in the reproductive cycle of Anopheles coluzzii, which is one of the principal Afrotropical malaria vector mosquitoes. Several studies suggest this decision is mediated by semiochemicals associated with potential oviposition sites. To better understand the chemosensory basis of this behavior and identify compounds that can modulate oviposition, we examined the generally held hypothesis that suboptimal larval habitats give rise to semiochemicals that negatively influence the oviposition preference of gravid females. Dual-choice bioassays indicated that oviposition sites conditioned in this manner do indeed foster significant and concentration dependent aversive effects on the oviposition site selection of gravid females. Headspace analyses derived from aversive habitats consistently noted the presence of dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS) and 6-methyl-5-hepten-2-one (sulcatone) each of which unitarily affected An. coluzzii oviposition preference. Electrophysiological assays across the antennae, maxillary palp, and labellum of gravid An. coluzzii revealed differential responses to these semiochemicals. Taken together, these findings validate the hypothesis in question and suggest that suboptimal environments for An. coluzzii larval development results in the release of DMDS, DMTS and sulcatone that impact the response valence of gravid females. PMID:26900947

  19. Suboptimal inhaler medication adherence and incorrect technique are common among chronic obstructive pulmonary disease patients.

    PubMed

    Sriram, Krishna B; Percival, Matthew

    2016-02-01

    Patients with chronic obstructive pulmonary disease (COPD) are routinely prescribed one or more inhaled medications. Adherence to inhaler medications and correct inhaler device technique are crucial to successful COPD management. The goals of this study were to estimate adherence and inhaler technique in a cohort of COPD patients. This was an observational study conducted on a sample of 150 COPD patients. Medication adherence was assessed using the Medication Adherence Report Scale (MARS). Inhaler technique was assessed using standardized checklists. Clinical data were collected using a proforma. Of the 150 patients (mean age 70.3 years, 52% male), 58% reported suboptimal adherence (MARS ≤ 24). High adherence to therapy (MARS = 25) was associated with older age (p = 0.001), but not any of the other studied variables. Medication non-adherence was not associated with COPD exacerbations. Errors (≥ 1) in inhaler technique were common across all of the types of inhaler devices reportedly used by patients, with the highest proportion of errors among Turbuhaler users (83%) and the least proportion of errors among Handihaler users (50%). No clinical variables were associated with errors in inhaler technique. Suboptimal adherence and errors in inhaler technique are common among COPD patients. No clinical variables to assist in the prediction of medication non-adherence and poor inhaler technique were identifiable. Consequently, regular assessment of medication adherence and inhaler technique should be incorporated into routine clinical practice to facilitate improved health outcomes among patients with COPD.

  20. Suboptimal Larval Habitats Modulate Oviposition of the Malaria Vector Mosquito Anopheles coluzzii.

    PubMed

    Suh, Eunho; Choe, Dong-Hwan; Saveer, Ahmed M; Zwiebel, Laurence J

    2016-01-01

    Selection of oviposition sites by gravid females is a critical behavioral step in the reproductive cycle of Anopheles coluzzii, which is one of the principal Afrotropical malaria vector mosquitoes. Several studies suggest this decision is mediated by semiochemicals associated with potential oviposition sites. To better understand the chemosensory basis of this behavior and identify compounds that can modulate oviposition, we examined the generally held hypothesis that suboptimal larval habitats give rise to semiochemicals that negatively influence the oviposition preference of gravid females. Dual-choice bioassays indicated that oviposition sites conditioned in this manner do indeed foster significant and concentration dependent aversive effects on the oviposition site selection of gravid females. Headspace analyses derived from aversive habitats consistently noted the presence of dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS) and 6-methyl-5-hepten-2-one (sulcatone) each of which unitarily affected An. coluzzii oviposition preference. Electrophysiological assays across the antennae, maxillary palp, and labellum of gravid An. coluzzii revealed differential responses to these semiochemicals. Taken together, these findings validate the hypothesis in question and suggest that suboptimal environments for An. coluzzii larval development results in the release of DMDS, DMTS and sulcatone that impact the response valence of gravid females.

  1. Sub-optimal parenting is associated with schizotypic and anxiety personality traits in adulthood.

    PubMed

    Giakoumaki, S G; Roussos, P; Zouraraki, C; Spanoudakis, E; Mavrikaki, M; Tsapakis, E M; Bitsios, P

    2013-05-01

    Part of the variation in personality characteristics has been attributed to the child-parent interaction and sub-optimal parenting has been associated with psychiatric morbidity. In the present study, an extensive battery of personality scales (Trait Anxiety Inventory, Behavioural Inhibition/Activation System questionnaire, Eysenck Personality Questionnaire-Revised, Temperament and Character Inventory, Schizotypal Traits Questionnaire, Toronto Alexithymia Scale) and the Parental Bonding Instrument (PBI) were administered in 324 adult healthy males to elucidate the effects of parenting on personality configuration. Personality variables were analysed using Principal Component Analysis (PCA) and the factors "Schizotypy", "Anxiety", "Behavioural activation", "Novelty seeking" and "Reward dependence" were extracted. Associations between personality factors with PBI "care" and "overprotection" scores were examined with regression analyses. Subjects were divided into "parental style" groups and personality factors were subjected to categorical analyses. "Schizotypy" and "Anxiety" were significantly predicted by high maternal overprotection and low paternal care. In addition, the Affectionless control group (low care/high overprotection) had higher "Schizotypy" and "Anxiety" compared with the Optimal Parenting group (high care/low overprotection). These results further validate sub-optimal parenting as an important environmental exposure and extend our understanding on the mechanisms by which it increases risk for psychiatric morbidity.

  2. Indirect and suboptimal control of gene expression is widespread in bacteria

    PubMed Central

    Price, Morgan N; Deutschbauer, Adam M; Skerker, Jeffrey M; Wetmore, Kelly M; Ruths, Troy; Mar, Jordan S; Kuehl, Jennifer V; Shao, Wenjun; Arkin, Adam P

    2013-01-01

    Gene regulation in bacteria is usually described as an adaptive response to an environmental change so that genes are expressed when they are required. We instead propose that most genes are under indirect control: their expression responds to signal(s) that are not directly related to the genes' function. Indirect control should perform poorly in artificial conditions, and we show that gene regulation is often maladaptive in the laboratory. In Shewanella oneidensis MR-1, 24% of genes are detrimental to fitness in some conditions, and detrimental genes tend to be highly expressed instead of being repressed when not needed. In diverse bacteria, there is little correlation between when genes are important for optimal growth or fitness and when those genes are upregulated. Two common types of indirect control are constitutive expression and regulation by growth rate; these occur for genes with diverse functions and often seem to be suboptimal. Because genes that have closely related functions can have dissimilar expression patterns, regulation may be suboptimal in the wild as well as in the laboratory. PMID:23591776

  3. Pigeon's (Columba livia) paradoxical preference for the suboptimal alternative in a complex foraging task.

    PubMed

    Zentall, Thomas R; Case, Jacob P; Luong, Jasmine

    2016-05-01

    Recent research has examined a task in which choice of 1 alternative A provides reinforcement and in addition, allows access to alternative B that also provides reinforcement. However, although initial choice of B also provides reinforcement, it does not also allow access to A. Thus, optimal performance would be to always choose A. Curiously, Salwiczek et al. (2012) reported that adult wrasse (cleaner) fish mastered this task within 50 trials, whereas monkeys and apes had great difficulty with it. The authors attributed the species differences to ecological differences in the species foraging experiences. However, Pepperberg and Hartsfield (2014) found that parrots too learned this task. In Experiment 1, using the manual presentation of stimuli, we found that pigeons actually showed a reliable preference for B, the suboptimal alternative. In Experiment 2, we replicated the suboptimal preference using an automated version of the task. We hypothesized that the pigeons may have been basing their preference on the frequency of reinforcement associated with each alternative (initially, all trials ended with choice of B, whereas only half of the trials involved choice of A). In Experiment 3, we tested the hypothesis that the pigeons' preference was influenced by the frequency of reinforcements associated with A and B. Thus, when the pigeon chose A, we replaced B with C, so reinforcement occurred to B only when they chose it first. With this procedure we found that B was no longer preferred over A. Thus, the data supported our hypothesis. (PsycINFO Database Record

  4. Identification of Metabolic Engineering Targets through Analysis of Optimal and Sub-Optimal Routes

    PubMed Central

    Soons, Zita I. T. A.; Ferreira, Eugénio C.

    2013-01-01

    Identification of optimal genetic manipulation strategies for redirecting substrate uptake towards a desired product is a challenging task owing to the complexity of metabolic networks, esp. in terms of large number of routes leading to the desired product. Algorithms that can exploit the whole range of optimal and suboptimal routes for product formation while respecting the biological objective of the cell are therefore much needed. Towards addressing this need, we here introduce the notion of structural flux, which is derived from the enumeration of all pathways in the metabolic network in question and accounts for the contribution towards a given biological objective function. We show that the theoretically estimated structural fluxes are good predictors of experimentally measured intra-cellular fluxes in two model organisms, namely, Escherichia coli and Saccharomyces cerevisiae. For a small number of fluxes for which the predictions were poor, the corresponding enzyme-coding transcripts were also found to be distinctly regulated, showing the ability of structural fluxes in capturing the underlying regulatory principles. Exploiting the observed correspondence between in vivo fluxes and structural fluxes, we propose an in silico metabolic engineering approach, iStruF, which enables the identification of gene deletion strategies that couple the cellular biological objective with the product flux while considering optimal as well as sub-optimal routes and their efficiency. PMID:23626708

  5. Rescue Procedures after Suboptimal Deep Brain Stimulation Outcomes in Common Movement Disorders

    PubMed Central

    Nagy, Adam M.; Tolleson, Christopher M.

    2016-01-01

    Deep brain stimulation (DBS) is a unique, functional neurosurgical therapy indicated for medication refractory movement disorders as well as some psychiatric diseases. Multicontact electrodes are placed in “deep” structures within the brain with targets varying depending on the surgical indication. An implanted programmable pulse generator supplies the electrodes with a chronic, high frequency electrical current that clinically mimics the effects of ablative lesioning techniques. DBS’s efficacy has been well established for its movement disorder indications (Parkinson’s disease, essential tremor, and dystonia). However, clinical outcomes are sometimes suboptimal, even in the absence of common, potentially reversible complications such as hardware complications, infection, poor electrode placement, and poor programming parameters. This review highlights some of the rescue procedures that have been explored in suboptimal DBS cases for Parkinson’s disease, essential tremor, and dystonia. To date, the data is limited and difficult to generalize, but a large majority of published reports demonstrate positive results. The decision to proceed with such treatments should be made on a case by case basis. Larger studies are needed to clearly establish the benefit of rescue procedures and to establish for which patient populations they may be most appropriate. PMID:27740598

  6. Suboptimal and optimal order policies for fixed and varying replenishment interval with declining market

    NASA Astrophysics Data System (ADS)

    Yu, Jonas C. P.; Wee, H. M.; Yang, P. C.; Wu, Simon

    2016-06-01

    One of the supply chain risks for hi-tech products is the result of rapid technological innovation; it results in a significant decline in the selling price and demand after the initial launch period. Hi-tech products include computers and communication consumer's products. From a practical standpoint, a more realistic replenishment policy is needed to consider the impact of risks; especially when some portions of shortages are lost. In this paper, suboptimal and optimal order policies with partial backordering are developed for a buyer when the component cost, the selling price, and the demand rate decline at a continuous rate. Two mathematical models are derived and discussed: one model has the suboptimal solution with the fixed replenishment interval and a simpler computational process; the other one has the optimal solution with the varying replenishment interval and a more complicated computational process. The second model results in more profit. Numerical examples are provided to illustrate the two replenishment models. Sensitivity analysis is carried out to investigate the relationship between the parameters and the net profit.

  7. Development of Sub-optimal Airway Protocols for the International Space Station (ISS) by the Medical Operation Support Team (MOST)

    NASA Technical Reports Server (NTRS)

    Polk, James D.; Parazynski, Scott; Kelly, Scott; Hurst, Victor, IV; Doerr, Harold K.

    2007-01-01

    Airway management techniques are necessary to establish and maintain a patent airway while treating a patient undergoing respiratory distress. There are situations where such settings are suboptimal, thus causing the caregiver to adapt to these suboptimal conditions. Such occurrences are no exception aboard the International Space Station (ISS). As a result, the NASA flight surgeon (FS) and NASA astronaut cohorts must be ready to adapt their optimal airway management techniques for suboptimal situations. Based on previous work conducted by the Medical Operation Support Team (MOST) and other investigators, the MOST had members of both the FS and astronaut cohorts evaluate two oral airway insertion techniques for the Intubating Laryngeal Mask Airway (ILMA) to determine whether either technique is sufficient to perform in suboptimal conditions within a microgravity environment. Methods All experiments were conducted in a simulated microgravity environment provided by parabolic flight aboard DC-9 aircraft. Each participant acted as a caregiver and was directed to attempt both suboptimal ILMA insertion techniques following a preflight instruction session on the day of the flight and a demonstration of the technique by an anesthesiologist physician in the simulated microgravity environment aboard the aircraft. Results Fourteen participants conducted 46 trials of the suboptimal ILMA insertion techniques. Overall, 43 of 46 trials (94%) conducted were properly performed based on criteria developed by the MOST and other investigators. Discussion The study demonstrated the use of airway management techniques in suboptimal conditions relating to space flight. Use of these techniques will provide a crew with options for using the ILMA to manage airway issues aboard the ISS. Although it is understood that the optimal method for patient care during space flight is to have both patient and caregiver restrained, these techniques provide a needed backup should conditions not present

  8. Tribal Business Assistance Center.

    ERIC Educational Resources Information Center

    Lansdowne, Michele

    The Salish Kootenai College Tribal Business Assistance Center was established in 1994 to provide technical assistance to individuals who are pursuing a small business. The center assists the entrepreneur by way of individual consultation with business advisors, small business workshops, and business administration courses that have been created…

  9. Sub-optimality in motor planning is retained throughout 9 days practice of 2250 trials

    PubMed Central

    Ota, Keiji; Shinya, Masahiro; Kudo, Kazutoshi

    2016-01-01

    Optimality in motor planning, as well as accuracy in motor execution, is required to maximize expected gain under risk. In this study, we tested whether humans are able to update their motor planning. Participants performed a coincident timing task with an asymmetric gain function, in which optimal response timing to gain the highest total score depends on response variability. Their behaviours were then compared using a Bayesian optimal decision model. After 9 days of practicing 2250 trials, the total score increased, and temporal variance decreased. On the other hand, the participants showed consistent risk-seeking or risk-averse behaviour, preserving suboptimal motor planning. These results suggest that a human’s computational ability to calculate an optimal motor plan is limited, and it is difficult to improve it through repeated practice with a score feedback. PMID:27869198

  10. A Wavelet Based Suboptimal Kalman Filter for Assimilation of Stratospheric Chemical Tracer Observations

    NASA Technical Reports Server (NTRS)

    Auger, Ludovic; Tangborn, Andrew; Atlas, Robert (Technical Monitor)

    2002-01-01

    A suboptimal Kalman filter system which evolves error covariances in terms of a truncated set of wavelet coefficients has been developed for the assimilation of chemical tracer observations of CH4. The truncation is carried out in such a way that the resolution of the error covariance, is reduced only in the zonal direction, where gradients are smaller. Assimilation experiments which last 24 days, and used different degrees of truncation were carried out. These reduced the covariance, by 90, 97 and 99 % and the computational cost of covariance propagation by 80, 93 and 96 % respectively. The difference in both error covariance and the tracer field between the truncated and full systems over this period were found to be not growing in the first case, and a growing relatively slowly in the later two cases. The largest errors in the tracer fields were found to occur in regions of largest zonal gradients in the tracer field.

  11. The design of suboptimal asymptotic stabilising controllers for nonlinear slowly varying systems

    NASA Astrophysics Data System (ADS)

    Binazadeh, T.; Shafiei, M. H.

    2014-04-01

    The design of asymptotic stabilising controllers for slowly varying nonlinear systems is considered in this paper. The designed control law is based on finding a slowly varying control Lyapunov function. Also, consideration of the Hamilton-Jacobi-Bellman equation showed that the proposed controller is a suboptimal controller and the response of the system may be very close to its optimal solution. The maximum admissible rate of changes of the system dynamic is also evaluated. This technique is first applied to a created example and then to a practical example (optimal autopilot design for an air vehicle). The air vehicle is modelled as a nonlinear slowly varying system and the efficiency of the designed autopilot in terms of transient responses, control signals and the values of cost function are shown by numerical simulations.

  12. The use of marginal-suboptimal donor organs: a practical solution for organ shortage.

    PubMed

    Abouna, George M

    2004-01-01

    The demand for organ transplantation has been rapidly increasing as a result of rising incidence of end-stage organ failure while the supply of cadaver organs from "ideal" or optimal donors has remained low and inadequate to meet the increasing demand. Yet many so called "marginal" or "suboptimal" organs have been discarded by many centers when many patients die each day while on the waiting list. In this review important data from our experience and that of several other centers have confirmed that using such marginal organs can provide a viable solution to organ shortage. Such organs include those from donors > 55 years, children < 5 years, diabetics, non-heart beating cadavers, and organs with extended preservation. Such organs can be successfully used with appropriate surgical techniques and immunosuppression protocols and the supply of donor organs can be increased by 25% to 30%.

  13. The problem of suboptimal complementary feeding practices in West Africa: what is the way forward?

    PubMed

    Issaka, Abukari I; Agho, Kingsley E; Page, Andrew N; Burns, Penelope L; Stevens, Garry J; Dibley, Michael J

    2015-10-01

    The objective of this paper was to review the policy implications of inadequate complementary feeding among children aged 6-23 months in West Africa. The review was undertaken from the initial results and findings from a series of studies on the comparison of complementary feeding indicators among children aged 6-23 months in four anglophone and seven francophone West African countries. It also examined a study of the determinants of suboptimal complementary feeding practices among children aged 6-23 months in those countries. Among the four complementary feeding indicators, it was only the introduction of solid, semi-solid or soft foods that was adequate among children in all the West African countries surveyed. The rates of the other complementary feeding indicators were found to be inadequate in all countries surveyed, although relatively better among children in the anglophone countries. Alarmingly, low rates of minimum acceptable diet were reported among children from both the anglophone and the francophone countries. Infants 6-11 months of age, children living in poor households, administrative/geographical regional differences and mothers' access to the media were some of the common risk factors for optimal complementary feeding practices in these countries. Assessing complementary feeding indicators and determinants of suboptimal complementary feeding practices in these West African countries is crucial to improving infant and young child feeding practices. It is recommended that governments and stakeholders of the West African countries studied make greater efforts to improve these critical practices in order to reduce child morbidity and mortality in the West Africa sub-region. Intervention studies on complementary feeding should target those socio-demographic factors that pose risks to optimal complementary feeding.

  14. Airway Microbiota and Bronchial Hyperresponsiveness in Patients with Sub-optimally Controlled Asthma

    PubMed Central

    Huang, Yvonne J.; Nelson, Craig E.; Brodie, Eoin L.; DeSantis, Todd Z.; Baek, Marshall S.; Liu, Jane; Woyke, Tanja; Allgaier, Martin; Bristow, Jim; Wiener-Kronish, Jeanine P.; Sutherland, E. Rand; King, Tonya S.; Icitovic, Nikolina; Martin, Richard J.; Calhoun, William J.; Castro, Mario; Denlinger, Loren C.; DiMango, Emily; Kraft, Monica; Peters, Stephen P.; Wasserman, Stephen I.; Wechsler, Michael E.; Boushey, Homer A.; Lynch, Susan V.

    2010-01-01

    Background Improvement in lung function following macrolide antibiotic therapy has been attributed to reduction in bronchial infection due to specific bacteria. However, the airway may be populated by a more diverse microbiota, and clinical features of asthma may be associated with characteristics of the airway microbiota present. Objective To determine if relationships exist between the composition of the airway bacterial microbiota and clinical features of asthma, using culture-independent tools capable of detecting the presence and relative abundance of most known bacteria. Methods In this pilot study, bronchial epithelial brushings were collected from sixty-five adults with sub-optimally controlled asthma participating in a multicenter study of the effects of clarithromycin on asthma control, and ten healthy subjects. A combination of high-density 16S rRNA microarray and parallel clone library-sequencing analysis was used to profile the microbiota and examine relationships with clinical measurements. Results Compared to controls, 16S rRNA amplicon concentrations (a proxy for bacterial burden) and bacterial diversity were significantly higher among asthmatic patients. In multivariate analyses, airway microbiota composition and diversity were significantly correlated with bronchial hyperresponsiveness. Specifically, the relative abundance of particular phylotypes, including members of the Comamonadaceae, Sphingomonadaceae, Oxalobacteraceae and other bacterial families, were highly correlated with the degree of bronchial hyperresponsiveness. Conclusion The composition of bronchial airway microbiota is associated with the degree of bronchial hyperresponsiveness among patients with sub-optimally controlled asthma. These findings support the need for further functional studies to examine the potential contribution of members of the airway microbiota in asthma pathogenesis. PMID:21194740

  15. Maximizing DNA profiling success from sub-optimal quantities of DNA: a staged approach.

    PubMed

    Roeder, Amy D; Elsmore, Paul; Greenhalgh, Matt; McDonald, Andrew

    2009-03-01

    Obtaining genetic profiles from samples containing minimal amounts of DNA can be difficult. In forensic science, the vast majority of genetic profiles are generated using commercial kits that have been optimized for the amplification of a specific range of DNA concentrations. DNA extracted from many forensic samples falls below the kit manufacturers' specified concentrations either because there is not enough total DNA in the extract or the extract is so dilute that not enough volume of the extract can be added to the PCR. In order to develop a method to maximize SGM Plus and Identifiler profiling success from samples with sub-optimal quantities of DNA, thermocycle numbers and/or the amount of PCR product injected during capillary electrophoresis (termed Enhancement) of PCR products were increased. Increasing the number of thermocycles from 28 to 30 and/or two phases of Enhancement of both 28 and 30 thermocycle PCR products resulted in an increased number of scorable peaks. As expected with low template amounts of DNA, many of the samples showed allelic drop-out, heterozygote imbalances and sporadic, large stutter peaks. Enhancement decreased the amount of allelic drop-out observed and did not affect stutter peak or heterozygous peak height ratios. Although the PCR reactions from these samples should always be replicated before a reportable consensus profile is reached, Phase 1 and 2 Enhancement can maximize the profiling success from each reaction. Finally, a flexible, staged approach using 28 or 30 thermocycle PCR in combination with the Enhancement techniques described here is proposed for processing samples with sub-optimal quantities of DNA.

  16. AGATE animation - business theme

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Business jet 5 of 6. Advanced General Aviation Technology Experiment (AGATE). 'Smart airport' technologies are expected to be available in 5-10 years for both recreational and business transportation. Image from AGATE 'business jet' video animation.

  17. Risky Business

    NASA Technical Reports Server (NTRS)

    Yarbrough, Katherine

    2015-01-01

    During my internship I worked on two major projects, recommending improvements for the Center's Risk Management Workshop and helping with the strategic planning efforts for Safety and Mission Assurance (S&MA). The risk management improvements is the key project I worked on this semester through my internship, while the strategic planning is the secondary assignment. S&MA Business Office covers both aspects in its delegation, getting both spans some of the work done in the office. A risk is a future event with a negative consequence that has some probability of occurring. Safety and Mission Assurance identifies, analyzes, plans, and tracks risk. The directorate offers the Center a Risk Management Workshop, and part of the ongoing efforts of S&MA is to make continuous improvements to the RM Workshop. By using the Project Management Institute's (PMI) Standard for Risk Management, I performed a gap analysis to make improvements for our materials. I benchmarked the PMI's Risk Management Standard, compared our Risk Management Workshop materials to PMI's standard, and identified any gaps in our material. My major findings were presented to the Business Office of S&MA for a decision on whether or not to incorporate the improvements. These suggestions were made by attending JSC working group meetings, Health, Safety and Environment (HSE) panel reviews and various risk review meetings. The improvements provide better understanding of risk management processes and enhanced risk tracking knowledge and skills. Risk management is an integral part of any engineering discipline, getting exposed to this section of engineering will greatly help shape my career in the future. Johnson Space Center is a world leader in risk management processes; learning risk management here gives me a huge advantage over my peers, as well as understanding decision making in the context of risk management will help me to be a well-rounded engineer. Strategic planning is an area I had not previously

  18. Business Inspiration: Small Business Leadership in Recovery?

    ERIC Educational Resources Information Center

    Rae, David; Price, Liz; Bosworth, Gary; Parkinson, Paul

    2012-01-01

    Business Inspiration was a short, action-centred leadership and innovation development programme designed for owners and managers of smaller firms to address business survival and repositioning needs arising from the UK's economic downturn. The article examines the design and delivery of Business Inspiration and the impact of the programme on…

  19. School-Business Partnerships: Understanding Business Perspectives

    ERIC Educational Resources Information Center

    Badgett, Kevin

    2016-01-01

    School-business partnerships have been shown to enhance educational experiences for students. There has, however, been limited research demonstrating the priorities and perspectives of for-profit business leaders on those partnerships. In order to address that gap, the researcher interviewed business leaders in two different areas of Texas. After…

  20. 31 CFR 50.9 - Procedure for requesting general interpretations of statute.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requester should segregate and mark any confidential business or trade secret information clearly. Treasury... business or trade secret information, Treasury will make written requests for interpretations and responses... for information that had been designated by a requester as confidential business or trade...

  1. 31 CFR 50.9 - Procedure for requesting general interpretations of statute.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requester should segregate and mark any confidential business or trade secret information clearly. Treasury... business or trade secret information, Treasury will make written requests for interpretations and responses... for information that had been designated by a requester as confidential business or trade...

  2. 31 CFR 50.9 - Procedure for requesting general interpretations of statute.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requester should segregate and mark any confidential business or trade secret information clearly. Treasury... business or trade secret information, Treasury will make written requests for interpretations and responses... for information that had been designated by a requester as confidential business or trade...

  3. 31 CFR 50.9 - Procedure for requesting general interpretations of statute.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requester should segregate and mark any confidential business or trade secret information clearly. Treasury... business or trade secret information, Treasury will make written requests for interpretations and responses... for information that had been designated by a requester as confidential business or trade...

  4. Electrocardiographic interpretation skills of cardiology residents: are they competent?

    PubMed

    Sibbald, Matthew; Davies, Edward G; Dorian, Paul; Yu, Eric H C

    2014-12-01

    Achieving competency at electrocardiogram (ECG) interpretation among cardiology subspecialty residents has traditionally focused on interpreting a target number of ECGs during training. However, there is little evidence to support this approach. Further, there are no data documenting the competency of ECG interpretation skills among cardiology residents, who become de facto the gold standard in their practice communities. We tested 29 Cardiology residents from all 3 years in a large training program using a set of 20 ECGs collected from a community cardiology practice over a 1-month period. Residents interpreted half of the ECGs using a standard analytic framework, and half using their own approach. Residents were scored on the number of correct and incorrect diagnoses listed. Overall diagnostic accuracy was 58%. Of 6 potentially life-threatening diagnoses, residents missed 36% (123 of 348) including hyperkalemia (81%), long QT (52%), complete heart block (35%), and ventricular tachycardia (19%). Residents provided additional inappropriate diagnoses on 238 ECGs (41%). Diagnostic accuracy was similar between ECGs interpreted using an analytic framework vs ECGs interpreted without an analytic framework (59% vs 58%; F(1,1333) = 0.26; P = 0.61). Cardiology resident proficiency at ECG interpretation is suboptimal. Despite the use of an analytic framework, there remain significant deficiencies in ECG interpretation among Cardiology residents. A more systematic method of addressing these important learning gaps is urgently needed.

  5. Efficient Methods to Assimilate Satellite Retrievals Based on Information Content. Part 2; Suboptimal Retrieval Assimilation

    NASA Technical Reports Server (NTRS)

    Joiner, J.; Dee, D. P.

    1998-01-01

    One of the outstanding problems in data assimilation has been and continues to be how best to utilize satellite data while balancing the tradeoff between accuracy and computational cost. A number of weather prediction centers have recently achieved remarkable success in improving their forecast skill by changing the method by which satellite data are assimilated into the forecast model from the traditional approach of assimilating retrievals to the direct assimilation of radiances in a variational framework. The operational implementation of such a substantial change in methodology involves a great number of technical details, e.g., pertaining to quality control procedures, systematic error correction techniques, and tuning of the statistical parameters in the analysis algorithm. Although there are clear theoretical advantages to the direct radiance assimilation approach, it is not obvious at all to what extent the improvements that have been obtained so far can be attributed to the change in methodology, or to various technical aspects of the implementation. The issue is of interest because retrieval assimilation retains many practical and logistical advantages which may become even more significant in the near future when increasingly high-volume data sources become available. The central question we address here is: how much improvement can we expect from assimilating radiances rather than retrievals, all other things being equal? We compare the two approaches in a simplified one-dimensional theoretical framework, in which problems related to quality control and systematic error correction are conveniently absent. By assuming a perfect radiative transfer model and perfect knowledge of radiance and background error covariances, we are able to formulate a nonlinear local error analysis for each assimilation method. Direct radiance assimilation is optimal in this idealized context, while the traditional method of assimilating retrievals is suboptimal because it

  6. Sub-Optimal Ensemble Filters and distributed hydrologic modeling: a new challenge in flood forecasting

    NASA Astrophysics Data System (ADS)

    Baroncini, F.; Castelli, F.

    2009-09-01

    Data assimilation techniques based on Ensemble Filtering are widely regarded as the best approach in solving forecast and calibration problems in geophysics models. Often the implementation of statistical optimal techniques, like the Ensemble Kalman Filter, is unfeasible because of the large amount of replicas used in each time step of the model for updating the error covariance matrix. Therefore the sub optimal approach seems to be a more suitable choice. Various sub-optimal techniques were tested in atmospheric and oceanographic models, some of them are based on the detection of a "null space". Distributed Hydrologic Models differ from the other geo-fluid-dynamics models in some fundamental aspects that make complex to understanding the relative efficiency of the different suboptimal techniques. Those aspects include threshold processes , preferential trajectories for convection and diffusion, low observability of the main state variables and high parametric uncertainty. This research study is focused on such topics and explore them through some numerical experiments on an continuous hydrologic model, MOBIDIC. This model include both water mass balance and surface energy balance, so it's able to assimilate a wide variety of datasets like traditional hydrometric "on ground" measurements or land surface temperature retrieval from satellite. The experiments that we present concern to a basin of 700 kmq in center Italy, with hourly dataset on a 8 months period that includes both drought and flood events, in this first set of experiment we worked on a low spatial resolution version of the hydrologic model (3.2 km). A new Kalman Filter based algorithm is presented : this filter try to address the main challenges of hydrological modeling uncertainty. The proposed filter use in Forecast step a COFFEE (Complementary Orthogonal Filter For Efficient Ensembles) approach with a propagation of both deterministic and stochastic ensembles to improve robustness and convergence

  7. Suboptimal inhibition of platelet cyclo-oxygenase-1 (COX-1) by aspirin in lupus erythematosus: Association with metabolic syndrome

    PubMed Central

    Kawai, Vivian K.; Avalos, Ingrid; Oeser, Annette; Oates, John A.; Milne, Ginger L.; Solus, Joseph F.; Chung, Cecilia P.; Stein, C. Michael

    2013-01-01

    Objectives Low-dose aspirin prevents platelet aggregation by suppressing thromboxane A2 synthesis. However, in some individuals thromboxane A2 suppression by aspirin is impaired, indicating suboptimal inhibition of platelet COX-1 by aspirin. Because patients with systemic lupus erythematosus (SLE) have increased risk of thrombotic events, many receive aspirin; however, the efficacy of aspirin in SLE has not been determined. We examined the hypothesis that aspirin response is impaired in SLE. Methods We assessed the effect of aspirin by measuring concentrations of the stable metabolite of thromboxane A2 - serum thromboxane B2 (sTxB2), before and after treatment with 81 mg daily aspirin for 7 days in 34 patients with SLE and 36 control subjects. The inability to suppress sTxB2 synthesis to <10 ng/ml represents suboptimal inhibition of platelet COX-1 by aspirin. Results Aspirin almost completely suppressed sTXB2 in control subjects to 1.5, [0.8–2.7] ng/ml (median and interquartile ranges [IQR]), but had less effect in patients with SLE (3.1, [2.2–5.3] ng/ml) (P=0.002). A suboptimal effect of aspirin was present in 15% (5/34) of the patients with SLE but not in control subjects (0/36) (P=0.023). Incomplete responders were more likely to have metabolic syndrome (P=0.048), obesity (P=0.048) and higher concentrations of CRP (P=0.018). Conclusion The pharmacologic effect of aspirin is suboptimal in 15% of patients with SLE but in none of the control subjects, and the suboptimal response was associated with metabolic syndrome, obesity, and higher CRP concentrations. PMID:24022862

  8. Business Management Course Guide.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Vocational Education.

    This course guide is designed for teaching about the U.S. business system. Students are introduced to management functions and the background knowledge/skills necessary to be a successful manager. The guide contains 10 competency goals: (1) nature of U.S. business; (2) environment of business; (3) types of business ownership; (4) management…

  9. Is Business Ethics Dying?

    ERIC Educational Resources Information Center

    Pamental, George L.

    1991-01-01

    Discusses the need for business ethics courses in undergraduate and graduate business degree programs. Describes reasons for and objections to such programs. Explains that business ethics instruction requires varied case studies, adequate teaching materials, cooperation between philosophers and business faculty, and instructors who are forthcoming…

  10. Effects of Suboptimally Presented Erotic Pictures on Moral Judgments: A Cross-Cultural Comparison

    PubMed Central

    Martí-Vilar, Manuel; Arango, Olber Eduardo

    2016-01-01

    Previous research has identified a set of core factors that influence moral judgments. The present study addresses the interplay between moral judgments and four factors: (a) incidental affects, (b) sociocultural context, (c) type of dilemma, and (d) participant’s sex. We asked participants in two different countries (Colombia and Spain) to judge the acceptability of actions in response to personal and impersonal moral dilemmas. Before each dilemma an affective prime (erotic, pleasant or neutral pictures) was presented suboptimally. Our results show that: a) relative to neutral priming, erotic primes increase the acceptance of harm for a greater good (i.e., more utilitarian judgments), b) relative to Colombians, Spanish participants rated causing harm as less acceptable, c) relative to impersonal dilemmas, personal dilemmas reduced the acceptance of harm, and d) relative to men, women were less likely to consider harm acceptable. Our results are congruent with findings showing that sex is a crucial factor in moral cognition, and they extend previous research by showing the interaction between culture and incidental factors in the making of moral judgments. PMID:27367795

  11. Suboptimal HIV Testing Uptake Among Men Who Engage in Commercial Sex Work with Men in Asia

    PubMed Central

    Jin, Harry; Friedman, Mackey Reuel; Lim, Sin How; Guadamuz, Thomas E.

    2016-01-01

    Abstract Purpose: Men who have sex with men and are sex workers (MSMSW) are disproportionately affected by the growing and emerging HIV epidemic. As sex work and same-sex behavior are heavily stigmatized and often illegal in most Asian countries, HIV research focusing on MSMSW has been limited. The goal of this analysis is to examine HIV testing practices and identify correlates of HIV testing among MSMSW in Asia. Methods: The Asia Internet MSM Sex Survey, an online cross-sectional survey of 10,861 men who have sex with men (MSM), was conducted in 2010. Data on sociodemographic characteristics, HIV testing behaviors, and sexual behaviors were collected. Five hundred and seventy-four HIV-negative/unknown respondents reported receiving payment for sex with men at least once in the past 6 months and were included in this analysis. Multivariable logistic regression was conducted to identify independent correlates of HIV testing in the past year. Results: About half (48.6%) of the participants had been tested for HIV at least once within the past year, and 30.5% had never been tested. We also found that MSMSW participants who engaged in risky behaviors were less likely to be tested. Conclusion: While one might expect a high HIV testing rate among MSMSW due to the risks associated with engaging in sex work, we found that HIV testing uptake is suboptimal among MSMSW in Asia. These results suggest that targeted HIV prevention and testing promotion among MSMSW are needed. PMID:26982598

  12. Las Vegas algorithms for gene recognition: Suboptimal and error-tolerant spliced alignment

    SciTech Connect

    Sze, Sing-Hoi; Pevzner, P.A.

    1997-12-01

    Recently, Gelfand, Mironov and Pevzner proposed a spliced alignment approach to gene recognition that provides 99% accurate recognition of human gene if a related mammalian protein is available. However, even 99% accurate gene predictions are insufficient for automated sequence annotation in large-scale sequencing projects and therefore have to be complemented by experimental gene verification. 100% accurate gene predictions would lead to a substantial reduction of experimental work on gene identification. Our goal is to develop an algorithm that either predicts an exon assembly with accuracy sufficient for sequence annotation or warns a biologist that the accuracy of a prediction is insufficient and further experimental work is required. We study suboptimal and error-tolerant spliced alignment problems as the first steps towards such an algorithm, and report an algorithm which provides 100% accurate recognition of human genes in 37% of cases (if a related mammalian protein is available). For 52% of genes, the algorithm predicts at least one exon with 100% accuracy. 30 refs., 1 fig., 3 tabs.

  13. Suboptimal chlorine treatment of drinking water leads to selection of multidrug-resistant Pseudomonas aeruginosa.

    PubMed

    Shrivastava, Richa; Upreti, R K; Jain, S R; Prasad, K N; Seth, P K; Chaturvedi, U C

    2004-06-01

    The present study was undertaken to investigate the spectrum of bacteria present in the River Gomti water before and after chlorination for drinking purposes. We observed that the strains of Pseudomonas aeruginosa that survived chlorination on three out of seven occasions were resistant to almost all the antibiotics tested. The chlorine-resistant bacteria had mucoid colonies and grew better at 24 degrees C. All attempts to isolate the plasmid responsible for chlorine resistance were unsuccessful. Laboratory experiments using different strains of the P. aeruginosa in distilled water showed that only the resistant strain survived chlorine treatment at a dose of < or =500 microg/L. Similar results were obtained when water collected from seven different sites on the River Gomti was treated with graded doses of chlorine. At the higher dose of chlorine, all the bacteria died in 30 min, whereas with lower doses all the bacteria survived. The present study underscores the importance of measuring water chlorine concentrations to assure they are sufficiently high to remove pathogenic bacteria from drinking water. To our knowledge, this is the first report in the literature of the selection of multidrug-resistant bacteria by suboptimal chlorine treatment of water.

  14. Mixed-phenotype acute leukemia: suboptimal treatment when the 2008/2016 WHO classification is used

    PubMed Central

    Pomerantz, Alan; Rodriguez-Rodriguez, Sergio; Demichelis-Gomez, Roberta; Barrera-Lumbreras, Georgina; Barrales-Benitez, Olga; Lopez-Karpovitch, Xavier

    2016-01-01

    Background Different criteria have been used to diagnose mixed-phenotype acute leukemia (MPAL), which has impacted the number of individuals diagnosed with this pathology. Better outcomes have been reported when using acute lymphoblastic leukemia (ALL)-type chemotherapy in the treatment of MPAL. Methods We compared the outcome of 4 groups of patients with MPAL. Group 1 included patients diagnosed using the 2008/2016 World Health Organization (WHO) classification; group 2 included patients diagnosed using the European Group for the Immunological Characterization of Leukemias (EGIL) criteria; group 3 included patients diagnosed using either the EGIL or the 2008/2016 WHO criteria; and group 4 was comprised of patients diagnosed with MPAL using the EGIL classification only. Results We found a significantly worse disease-free survival (groups 1-4) and overall survival (OS) (groups 2 and 3) when comparing MPAL patients to other acute leukemia (AL) patients. A significantly better OS was obtained in patients (groups 2-4) treated with ALL-type chemotherapy compared to acute myeloid leukemia (AML)-type regimens. Conclusion In light of these results, and because a trend (P=0.06) was found with regard to a better OS in group 4 when compared to other AL patients, an argument can be made that the 2008/2016 WHO classification is underpowered to diagnose all MPAL cases, potentially resulting in the suboptimal treatment of some individuals with AL. PMID:28090485

  15. Suboptimal antiretroviral therapy adherence among HIV-infected adults in Guangzhou, China

    PubMed Central

    Muessig, Kathryn E.; McLaughlin, Megan M.; Nie, Jing Min; Cai, Weiping; Zheng, Heping; Yang, Ligang; Tucker, Joseph D.

    2014-01-01

    Despite China“s free antiretroviral treatment (ART) program, there are high rates of treatment failure, large sociodemographic disparities in care outcomes and emerging medication resistance. Understanding patient medication adherence behaviors and challenges could inform adherence interventions to maximize the individual and prevention benefits of ART. This study assessed recent non-adherence and treatment interruption among 813 HIV-infected adult outpatients in Guangzhou, China. Participants completed a behavioral survey, underwent chart review, and were tested for syphilis, gonorrhea, and chlamydia. Factors associated with suboptimal adherence were identified using univariate and multivariate logistic regression. Among 721 HIV-infected adults receiving ART, 18.9% reported recent non-adherence (any missed ART in the past 4 weeks) and 6.8% reported treatment interruption (four or more weeks of missed ART in the past year). Lower education, living alone, alcohol use and being on ART one to three years were associated with recent non-adherence. Male gender, lower education and being on ART one to three years were associated with treatment interruption. ART medication adherence interventions are needed in China that include individualized, long-term adherence plans sensitive to patients“ educational and economic situations. These interventions should also consider possible gender disparities in treatment outcomes and address the use of alcohol during ART. Successful ART medication adherence interventions in China can inform other international settings that face similar adherence challenges and disparities. PMID:24666239

  16. Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis

    PubMed Central

    2013-01-01

    Background Previous experiments have shown that the reduced gravity aboard the International Space Station (ISS) causes important alterations in Drosophila gene expression. These changes were shown to be intimately linked to environmental space-flight related constraints. Results Here, we use an array of different techniques for ground-based simulation of microgravity effects to assess the effect of suboptimal environmental conditions on the gene expression of Drosophila in reduced gravity. A global and integrative analysis, using “gene expression dynamics inspector” (GEDI) self-organizing maps, reveals different degrees in the responses of the transcriptome when using different environmental conditions or microgravity/hypergravity simulation devices. Although the genes that are affected are different in each simulation technique, we find that the same gene ontology groups, including at least one large multigene family related with behavior, stress response or organogenesis, are over represented in each case. Conclusions These results suggest that the transcriptome as a whole can be finely tuned to gravity force. In optimum environmental conditions, the alteration of gravity has only mild effects on gene expression but when environmental conditions are far from optimal, the gene expression must be tuned greatly and effects become more robust, probably linked to the lack of experience of organisms exposed to evolutionary novel environments such as a gravitational free one. PMID:23806134

  17. Suboptimal Nutritional Characteristics in Male and Female Soldiers Compared to Sports Nutrition Guidelines.

    PubMed

    Beals, Kim; Darnell, Matthew E; Lovalekar, Mita; Baker, Rachel A; Nagai, Takashi; San-Adams, Thida; Wirt, Michael D

    2015-12-01

    The purpose of this study was to evaluate the nutrient intake of male and female Soldiers in the 101 st Airborne Division (Air Assault) compared to sports nutrition standards for athletes, and to identify suboptimal eating characteristics that may impair physical performance and jeopardize military readiness. Male and female Soldiers from the 101 st Airborne Division (Air Assault) completed a 24-hour dietary recall and nutrition history questionnaire before anthropometric and body composition measurements were taken. Compared to sports nutrition guidelines, Soldiers of the 101 st under consume carbohydrates (males: 3.9 ± 2.0 vs. 5.0 g/kg, p < 0.001; females: 4.0 ± 2.1 vs. 5.0 g/kg, p = 0.001), male Soldiers eat too much fat (32.4% of kcal vs. <30% of kcal, p = 0.000) and saturated fat (males: 10.5 ± 3.9% of kcal vs. 10.0% of kcal, p = 0.044), and both males and females follow a meal pattern that may not optimize energy availability throughout the day. Eating too much fat and under fueling carbohydrate may negatively impact the adaptations to physical training and compromise overall health. Although Soldiers continue to participate in arduous training programs, future research should be aimed at determining the energy and macronutrient needs to fuel and recover from specific types of military training.

  18. Sub-optimal pit construction in predatory ant lion larvae (Myrmeleon sp.).

    PubMed

    Burgess, Matthew G

    2009-10-07

    The impacts on energy gains of two aspects of ant lion pit architecture were investigated in a natural population of pit-building ant lion larvae (Myrmeleon sp.) in Costa Rica. Field and laboratory settings were used to examine the impacts of circumference and depth of the pit on net energy gain rate. An optimization model predicted a point optimum circumference and angle of depression in an unconstrained system, and positive correlations between body mass, pit circumference, and pit angle of depression in the presence of physiological constraints on both measures. Such a physiological constraint is possible in this system due to a large one-time construction cost. All of these correlations were observed in a lab setting with filtered substrate and no competition; though none were significant in the field. Individuals additionally constructed wider, shallower pits in the field. These results are consistent with an angle of depression that is limited by the angle of repose of the substrate in the field, rather than physiology. These results provided suggestive evidence for sub-optimal pit dimensions in Myrmeleon sp., and for the importance of substrate type in understanding the architecture of natural ant lion pits. The model predicted that the frequency of relocation would not affect the optimal angle of depression, but it would affect the optimal pit circumference to a degree proportional to the square root of the change in the average time an ant lion occupies a single pit. These findings challenge the widely held assumption of adaptive optimality in animal foraging.

  19. Critical phenomena in communication/computation networks with various topologies and suboptimal to optimal resource allocation

    NASA Astrophysics Data System (ADS)

    Cogoni, Marco; Busonera, Giovanni; Anedda, Paolo; Zanetti, Gianluigi

    2015-01-01

    We generalize previous studies on critical phenomena in communication networks [1,2] by adding computational capabilities to the nodes. In our model, a set of tasks with random origin, destination and computational structure is distributed on a computational network, modeled as a graph. By varying the temperature of a Metropolis Montecarlo, we explore the global latency for an optimal to suboptimal resource assignment at a given time instant. By computing the two-point correlation function for the local overload, we study the behavior of the correlation distance (both for links and nodes) while approaching the congested phase: a transition from peaked to spread g(r) is seen above a critical (Montecarlo) temperature Tc. The average latency trend of the system is predicted by averaging over several network traffic realizations while maintaining a spatially detailed information for each node: a sharp decrease of performance is found over Tc independently of the workload. The globally optimized computational resource allocation and network routing defines a baseline for a future comparison of the transition behavior with respect to existing routing strategies [3,4] for different network topologies.

  20. Motor planning under temporal uncertainty is suboptimal when the gain function is asymmetric

    PubMed Central

    Ota, Keiji; Shinya, Masahiro; Kudo, Kazutoshi

    2015-01-01

    For optimal action planning, the gain/loss associated with actions and the variability in motor output should both be considered. A number of studies make conflicting claims about the optimality of human action planning but cannot be reconciled due to their use of different movements and gain/loss functions. The disagreement is possibly because of differences in the experimental design and differences in the energetic cost of participant motor effort. We used a coincident timing task, which requires decision making with constant energetic cost, to test the optimality of participant's timing strategies under four configurations of the gain function. We compared participant strategies to an optimal timing strategy calculated from a Bayesian model that maximizes the expected gain. We found suboptimal timing strategies under two configurations of the gain function characterized by asymmetry, in which higher gain is associated with higher risk of zero gain. Participants showed a risk-seeking strategy by responding closer than optimal to the time of onset/offset of zero gain. Meanwhile, there was good agreement of the model with actual performance under two configurations of the gain function characterized by symmetry. Our findings show that human ability to make decisions that must reflect uncertainty in one's own motor output has limits that depend on the configuration of the gain function. PMID:26236227

  1. Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma.

    PubMed

    Azzarito, Tommaso; Venturi, Giulietta; Cesolini, Albino; Fais, Stefano

    2015-01-28

    Tumor acidity is now considered an important determinant of drug-resistance and tumor progression, and anti-acidic approaches, such as Proton Pump inhibitors (PPIs), have demonstrated promising antitumor and chemo-sensitizing efficacy. The main purpose of the present study was to evaluate the possible PPI-induced sensitization of human melanoma cells to Paclitaxel (PTX). Our results show that PTX and the PPI Lansoprazole (LAN) combination was extremely efficient against metastatic melanoma cells, as compared to the single treatments, both in vitro and in vivo. We also showed that acidity plays an important role on the anti-tumor activity of these drugs, being detrimental for PTX activity, while crucial for the synergistic effect of PTX following pretreatment with LAN, due to its nature of pro-drug needing protonation for a full activation. We obtained straightforward results in a human melanoma xenograft model combining well tolerated LAN doses with suboptimal and poorly toxic doses of PTX. With this study we provide a clear evidence that the PPI LAN may be included in new combined therapy of human melanoma together with low doses of PTX.

  2. Effects of Suboptimally Presented Erotic Pictures on Moral Judgments: A Cross-Cultural Comparison.

    PubMed

    Olivera-La Rosa, Antonio; Corradi, Guido; Villacampa, Javier; Martí-Vilar, Manuel; Arango, Olber Eduardo; Rosselló, Jaume

    2016-01-01

    Previous research has identified a set of core factors that influence moral judgments. The present study addresses the interplay between moral judgments and four factors: (a) incidental affects, (b) sociocultural context, (c) type of dilemma, and (d) participant's sex. We asked participants in two different countries (Colombia and Spain) to judge the acceptability of actions in response to personal and impersonal moral dilemmas. Before each dilemma an affective prime (erotic, pleasant or neutral pictures) was presented suboptimally. Our results show that: a) relative to neutral priming, erotic primes increase the acceptance of harm for a greater good (i.e., more utilitarian judgments), b) relative to Colombians, Spanish participants rated causing harm as less acceptable, c) relative to impersonal dilemmas, personal dilemmas reduced the acceptance of harm, and d) relative to men, women were less likely to consider harm acceptable. Our results are congruent with findings showing that sex is a crucial factor in moral cognition, and they extend previous research by showing the interaction between culture and incidental factors in the making of moral judgments.

  3. Hybrid suboptimal control of multi-rate multi-loop sampled-data systems

    NASA Technical Reports Server (NTRS)

    Shieh, Leang S.; Chen, Gwangchywan; Tsai, Jason S. H.

    1992-01-01

    A hybrid state-space controller is developed for suboptimal digital control of multirate multiloop multivariable continuous-time systems. First, an LQR is designed for a continuous-time subsystem which has a large bandwidth and is connnected in the inner loop of the overall system. The designed LQR would optimally place the eigenvalues of a closed-loop subsystem in the common region of an open sector bounded by sector angles + or - pi/2k for k = 2 or 3 from the negative real axis and the left-hand side of a vertical line on the negative real axis in the s-plane. Then, the developed continuous-time state-feedback gain is converted into an equivalent fast-rate discrete-time state-feedback gain via a digital redesign technique (Tsai et al. 1989, Shieh et al. 1990) reviewed here. A real state reconstructor is redeveloped utilizing the fast-rate input-output data of the system of interest. The design procedure of multiloop multivariable systems using multirate samplers is shown, and a terminal homing missile system example is used to demonstrate the effectiveness of the proposed method.

  4. A pseudo-dynamic sub-optimal filter for elastography under static loading and measurements

    NASA Astrophysics Data System (ADS)

    Banerjee, B.; Roy, D.; Vasu, R. M.

    2009-01-01

    We propose a pseudo-dynamic form of a sub-optimal Kalman filter for elastography of plane-strain models of soft tissues under strictly static deformations and partial measurements. Since the tissue material is nearly incompressible and is thus prone to volumetric locking via standard displacement-based finite element formulations, we use a Cosserat point approach for deriving the static equilibrium equations. A pseudo-dynamical form of the equilibrium equations, with added noise and appropriate augmentation by the discretized shear modulus as additional states, is then adopted as the process equation such that its steady-state solution approaches the static response of the plane-strain model. A fictitious noise of small intensity is also added to the measurement equation and, following linearization of the process equation, a Kalman filter is applied to reconstruct the shear modulus profile. We present several numerical experiments, some of which also bring forth the relative advantages of the proposed approach over a deterministic reconstruction based on a quasi-Newton search.

  5. A Wavelet based Suboptimal Kalman Filter for Assimilation of Stratospheric Chemical Tracer Observations

    NASA Technical Reports Server (NTRS)

    Tangborn, Andrew; Auger, Ludovic

    2003-01-01

    A suboptimal Kalman filter system which evolves error covariances in terms of a truncated set of wavelet coefficients has been developed for the assimilation of chemical tracer observations of CH4. This scheme projects the discretized covariance propagation equations and covariance matrix onto an orthogonal set of compactly supported wavelets. Wavelet representation is localized in both location and scale, which allows for efficient representation of the inherently anisotropic structure of the error covariances. The truncation is carried out in such a way that the resolution of the error covariance is reduced only in the zonal direction, where gradients are smaller. Assimilation experiments which last 24 days, and used different degrees of truncation were carried out. These reduced the covariance size by 90, 97 and 99 % and the computational cost of covariance propagation by 80, 93 and 96 % respectively. The difference in both error covariance and the tracer field between the truncated and full systems over this period were found to be not growing in the first case, and growing relatively slowly in the later two cases. The largest errors in the tracer fields were found to occur in regions of largest zonal gradients in the constituent field. This results indicate that propagation of error covariances for a global two-dimensional data assimilation system are currently feasible. Recommendations for further reduction in computational cost are made with the goal of extending this technique to three-dimensional global assimilation systems.

  6. Preimplant Normothermic Liver Perfusion of a Suboptimal Liver Donated After Circulatory Death.

    PubMed

    Watson, C J E; Kosmoliaptsis, V; Randle, L V; Russell, N K; Griffiths, W J H; Davies, S; Mergental, H; Butler, A J

    2016-01-01

    Livers retrieved after circulatory death are associated with an increased incidence of primary nonfunction, early allograft dysfunction, and biliary strictures. The authors report a case of preimplant normothermic perfusion of a suboptimal liver from a 57-year-old donor after circulatory death who had been hospitalized for 9 days; predonation alanine transaminase level was 63 IU/L, and the period from withdrawal of life-supporting treatment to circulatory arrest was 150 minutes. After 5 hours of static cold storage, the liver was subject to normothermic machine perfusion with a plasma-free red cell-based perfusate. Perfusate lactate level fell from 7.2 to 0.3 mmol/L within 74 minutes of ex situ perfusion, at which point perfusate alanine transaminase level was 1152 IU/L and urea concentration was 9.4 mmol/L. After 132 minutes, normothermic perfusion was stopped and implantation begun. After transplantation, the patient made an uneventful recovery and was discharged on day 8; liver biochemistry was normal by day 19 and has remained normal thereafter. Donor common bile duct excised at implantation showed preservation of peribiliary glands, and cholangiography 6 months posttransplantation showed no evidence of cholangiopathy. Preimplant ex situ normothermic perfusion of the liver appears to be a promising way to evaluate a marginal liver before transplantation and may modify the response to ischemia.

  7. Noisy decision thresholds can account for suboptimal detection of low coherence motion.

    PubMed

    Price, Nicholas S C; VanCuylenberg, John B

    2016-01-04

    Noise in sensory signals can vary over both space and time. Moving random dot stimuli are commonly used to quantify how the visual system accounts for spatial noise. In these stimuli, a fixed proportion of "signal" dots move in the same direction and the remaining "noise" dots are randomly replotted. The spatial coherence, or proportion of signal versus noise dots, is fixed across time; however, this means that little is known about how temporally-noisy signals are integrated. Here we use a stimulus with low temporal coherence; the signal direction is only presented on a fraction of frames. Human observers are able to reliably detect and discriminate the direction of a 200 ms motion pulse, even when just 25% of frames within the pulse move in the signal direction. Using psychophysical reverse-correlation analyses, we show that observers are strongly influenced by the number of near-target directions spread throughout the pulse, and that consecutive signal frames have only a small additional influence on perception. Finally, we develop a model inspired by the leaky integration of the responses of direction-selective neurons, which reliably represents motion direction, and which can account for observers' sub-optimal detection of motion pulses by incorporating a noisy decision threshold.

  8. Suboptimal antiretroviral therapy adherence among HIV-infected adults in Guangzhou, China.

    PubMed

    Muessig, Kathryn E; McLaughlin, Megan M; Nie, Jing Min; Cai, Weiping; Zheng, Heping; Yang, Ligang; Tucker, Joseph D

    2014-01-01

    Despite China's free antiretroviral therapy (ART) program, there are high rates of treatment failure, large sociodemographic disparities in care outcomes and emerging medication resistance. Understanding patient medication adherence behaviors and challenges could inform adherence interventions to maximize the individual and prevention benefits of ART. This study assessed recent nonadherence and treatment interruption among 813 HIV-infected adult outpatients in Guangzhou, China. Participants completed a behavioral survey, underwent chart review, and were tested for syphilis, gonorrhea, and chlamydia. Factors associated with suboptimal adherence were identified using univariate and multivariate logistic regression. Among 721 HIV-infected adults receiving ART, 18.9% reported recent nonadherence (any missed ART in the past four weeks) and 6.8% reported treatment interruption (four or more weeks of missed ART in the past year). Lower education, living alone, alcohol use, and being on ART one to three years were associated with recent nonadherence. Male gender, lower education, and being on ART one to three years were associated with treatment interruption. ART medication adherence interventions are needed in China that include individualized, long-term adherence plans sensitive to patients' educational and economic situations. These interventions should also consider possible gender disparities in treatment outcomes and address the use of alcohol during ART. Successful ART medication adherence interventions in China can inform other international settings that face similar adherence challenges and disparities.

  9. Interpretation in Sweden.

    ERIC Educational Resources Information Center

    Hultman, Sven-G.

    1987-01-01

    Describes some of the interpretive developments underway in Sweden. Discusses some programs in both natural and cultural interpretation. Calls for increasing the purpose and content of heritage preservation and conservation to the general public. (TW)

  10. U-interpreter

    SciTech Connect

    Arvind; Gostelow, K.P.

    1982-02-01

    The author argues that by giving a unique name to every activity generated during a computation, the u-interpreter can provide greater concurrency in the interpretation of data flow graphs. 19 references.

  11. Progress in enzyme immunoassays: production of reagents, experimental design, and interpretation*

    PubMed Central

    Kurstak, Edouard

    1985-01-01

    Enzyme immunoassays represent in many cases the preferred procedure for the detection of antigens or corresponding antibodies. However, many of the current procedures are performed suboptimally. This article reviews the available designs, auxiliary recognition systems, production and purification of antibodies, conjugation procedures, solid-phase materials, recording and interpretation of results, and quality control and standardization of procedures to improve the reproducibility of tests. PMID:3910300

  12. Interpreting. PEPNet Tipsheet

    ERIC Educational Resources Information Center

    Darroch, Kathleen

    2010-01-01

    An interpreter's role is to facilitate communication and convey all auditory and signed information so that both hearing and deaf individuals may fully interact. The common types of services provided by interpreters are: (1) American Sign Language (ASL) Interpretation--a visual-gestural language with its own linguistic features; (2) Sign Language…

  13. Interpreting. NETAC Teacher Tipsheet.

    ERIC Educational Resources Information Center

    Darroch, Kathy; Marshall, Liza

    This tipsheet explains that an interpreter's role is to facilitate communication and convey all auditory and signed information so that individuals with and without hearing may fully interact. It outlines the common types of services provided by interpreters, and discusses principles guiding the professional behaviors of interpreters. When working…

  14. Suboptimal response to ferrous sulfate in iron-deficient patients taking omeprazole.

    PubMed

    Ajmera, Akash V; Shastri, Ghanshyam S; Gajera, Mithil J; Judge, Thomas A

    2012-05-01

    Iron deficiency anemia is commonly encountered in outpatient practice. Gastric acid is one of the important factors for optimum absorption of iron. Proton pump inhibitors are very commonly prescribed medications. One of the debated effects of proton pump inhibitors is on oral iron absorption. Their effect on absorption of oral iron supplementation in iron-deficient patients has not been studied. At the Cooper Hematology Outpatient office, we reviewed charts of iron-deficient anemic patients who were on omeprazole for the last 4 years. Fifty patients having no apparent ongoing blood loss, having other causes of anemia especially that of chronic diseases ruled out, and on omeprazole while starting ferrous sulfate therapy for iron deficiency were selected for chart review. The iron-study results at the start of oral ferrous sulfate therapy and at 3 months follow-up were compared to evaluate the response of ferrous sulfate. The mean hemoglobin change was 0.8 ± 1.2 g/L. The mean change in ferrtin values was 10.2 ± 7.8 μg/L. Only 16% of the patients had a normal response to hemoglobin levels (rise of >2 g/dL), and only 40% had a normal response to ferritin levels (rise of >20 μg/dL). The average age of patients having a suboptimal response to both hemoglobin and ferritin was significantly higher compared with that of the patients with an optimal response. Omeprazole and possibly all proton pump inhibitors decrease the absorption of oral iron supplementation. Iron-deficient patients taking proton pump inhibitors may have to be treated with high dose iron therapy for a longer duration or with intravenous iron therapy.

  15. Altered Innate Immune Responses in Neutrophils from Patients with Well- and Suboptimally Controlled Asthma

    PubMed Central

    Tang, Francesca S. M.; Foxley, Gloria J.; Gibson, Peter G.; Burgess, Janette K.; Baines, Katherine J.; Oliver, Brian G.

    2015-01-01

    Background. Respiratory infections are a major cause of asthma exacerbations where neutrophilic inflammation dominates and is associated with steroid refractory asthma. Structural airway cells in asthma differ from nonasthmatics; however it is unknown if neutrophils differ. We investigated neutrophil immune responses in patients who have good (AGood) and suboptimal (ASubopt) asthma symptom control. Methods. Peripheral blood neutrophils from AGood (ACQ < 0.75, n = 11), ASubopt (ACQ > 0.75, n = 7), and healthy controls (HC) (n = 9) were stimulated with bacterial (LPS (1 μg/mL), fMLF (100 nM)), and viral (imiquimod (3 μg/mL), R848 (1.5 μg/mL), and poly I:C (10 μg/mL)) surrogates or live rhinovirus (RV) 16 (MOI1). Cell-free supernatant was collected after 1 h for neutrophil elastase (NE) and matrix metalloproteinase- (MMP-) 9 measurements or after 24 h for CXCL8 release. Results. Constitutive NE was enhanced in AGood neutrophils compared to HC. fMLF stimulated neutrophils from ASubopt but not AGood produced 50% of HC levels. fMLF induced MMP-9 was impaired in ASubopt and AGood compared to HC. fMLF stimulated CXCL8 but not MMP-9 was positively correlated with FEV1 and FEV1/FVC. ASubopt and AGood responded similarly to other stimuli. Conclusions. Circulating neutrophils are different in asthma; however, this is likely to be related to airflow limitation rather than asthma control. PMID:26663987

  16. SUBOPTIMAL INHIBITION OF PLATELET CYCLOOXYGENASE-1 BY ASPIRIN IN METABOLIC SYNDROME

    PubMed Central

    Smith, James P.; Haddad, Elias V.; Taylor, Mary B.; Oram, Denise; Blakemore, Dana; Chen, Qingxia; Boutaud, Olivier; Oates, John A.

    2012-01-01

    Interindividual variation in the ability of aspirin to inhibit platelet cyclooxygenase-1 (COX-1) could account for some on-treatment cardiovascular events. Here, we sought to determine whether there are clinical phenotypes that are associated with a suboptimal pharmacological effect of aspirin. In a prospective, 2-week study, we evaluated the effect of aspirin 81 mg on platelet COX-1 in 135 patients with stable CAD by measuring serum thromboxane B2 (sTxB2) as an indicator of inhibition of platelet COX-1. A nested randomized study compared enteric-coated with immediate-release formulations of aspirin. We found that sTxB2 was systematically higher among the 83 patients with metabolic syndrome than among the 52 patients without (median 4.0 ng/mL vs. 3.02 ng/mL, P=0.013). Twelve (14%) patients with metabolic syndrome, but none without metabolic syndrome, had sTxB2 levels consistent with inadequate inhibition of COX (sTxB2 ≥13 ng/mL). In linear regression models, metabolic syndrome (but none of its individual components) significantly associated with higher levels of log-transformed sTxB2 (P=0.006). Higher levels of sTxB2 associated with greater residual platelet function measured by aggregometry-based methods. Among the randomized subset, sTxB2 levels were systematically higher among patients receiving enteric-coated aspirin. Last, urinary 11-dehydrothromboxane B2 did not correlate with sTxB2, suggesting that the former should not be used to quantitate aspirin’s pharmacological effect on platelets. In conclusion, metabolic syndrome, which places patients at high risk for thrombotic cardiovascular events, strongly and uniquely associates with less effective inhibition of platelet COX-1 by aspirin. PMID:22311905

  17. Therapy of Primary Biliary Cirrhosis: Novel Approaches for Patients with Suboptimal Response to Ursodeoxycholic Acid.

    PubMed

    Parés, Albert

    2015-01-01

    Primary biliary cirrhosis (PBC) is a chronic cholestatic disease of presumed autoimmune pathogenesis, characterized by the inflammation and damage of the intrahepatic intermediate and small bile ducts, which eventually results in cirrhosis. A number of randomized and observational and pilot studies using several agents were carried out in the 80s, but no clear results or even harmful effects were reported. Over the past 2 decades, increasing evidence indicates that ursodeoxycholic acid (UDCA) - 13 to 16 mg/kg/day--is the treatment of choice for patients with PBC. Biochemical response to UDCA, assessed at 1 year, clearly predicts the long-term outcome, since in UDCA, responders survival is similar to that estimated for the matched control population. However, about 40% of patients have incomplete biochemical response and increased risk of progression and decreased survival free of transplantation. Patients with suboptimal biochemical response to UDCA outline the group in whom further single or combined treatments with UDCA are needed. Accordingly, data on the effect of fibrates alone or in combination with UDCA, and budesonide in combination with UDCA have been reported. The combined treatment of UDCA and fibrates in patients without optimal biochemical response to UDCA improves the degree of cholestasis and may minimize the long-term management of these patients. The results of the combined therapy of UDCA with budesonide are appealing but they should be established in large randomized trials. The effect of new agents such obeticholic acid are promising, since the addition of this farnesoide-X-receptor agonist bile acid in patients with stable UDCA dosage and increased alkaline phosphatase levels results in an improvement of cholestasis as compared to placebo, with a parallel decrease of aminotransferases and immunoglobulin M, as well as one surrogate marker of bile acid synthesis. New molecular therapies are currently being investigated.

  18. Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo.

    PubMed

    Grace, Patricia S; Ernst, Joel D

    2016-01-01

    Mycobacterium tuberculosis commonly causes persistent or chronic infection, despite the development of Ag-specific CD4 T cell responses. We hypothesized that M. tuberculosis evades elimination by CD4 T cell responses by manipulating MHC class II Ag presentation and CD4 T cell activation and tested this hypothesis by comparing activation of Ag85B-specific CD4 T cell responses to M. tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) Pasteur in vivo and in vitro. We found that, although M. tuberculosis persists in lungs of immunocompetent mice, M. bovis BCG is cleared, and clearance is T cell dependent. We further discovered that M. tuberculosis-infected macrophages and dendritic cells activate Ag85B-specific CD4 T cells less efficiently and less effectively than do BCG-infected cells, in vivo and in vitro, despite higher production and secretion of Ag85B by M. tuberculosis. During BCG infection, activation of Ag85B-specific CD4 T cells requires fewer infected dendritic cells and fewer Ag-producing bacteria than during M. tuberculosis infection. When dendritic cells containing equivalent numbers of M. tuberculosis or BCG were transferred to mice, BCG-infected cells activated proliferation of more Ag85B-specific CD4 T cells than did M. tuberculosis-infected cells. Differences in Ag85B-specific CD4 T cell activation were attributable to differential Ag presentation rather than differential expression of costimulatory or inhibitory molecules. These data indicate that suboptimal Ag presentation contributes to persistent infection and that limiting Ag presentation is a virulence property of M. tuberculosis.

  19. Suboptimal Herd Performance Amplifies the Spread of Infectious Disease in the Cattle Industry

    PubMed Central

    Gates, M. Carolyn; Woolhouse, Mark E. J.

    2014-01-01

    Farms that purchase replacement breeding cattle are at increased risk of introducing many economically important diseases. The objectives of this analysis were to determine whether the total number of replacement breeding cattle purchased by individual farms could be reduced by improving herd performance and to quantify the effects of such reductions on the industry-level transmission dynamics of infectious cattle diseases. Detailed information on the performance and contact patterns of British cattle herds was extracted from the national cattle movement database as a case example. Approximately 69% of beef herds and 59% of dairy herds with an average of at least 20 recorded calvings per year purchased at least one replacement breeding animal. Results from zero-inflated negative binomial regression models revealed that herds with high average ages at first calving, prolonged calving intervals, abnormally high or low culling rates, and high calf mortality rates were generally more likely to be open herds and to purchase greater numbers of replacement breeding cattle. If all herds achieved the same level of performance as the top 20% of herds, the total number of replacement beef and dairy cattle purchased could be reduced by an estimated 34% and 51%, respectively. Although these purchases accounted for only 13% of between-herd contacts in the industry trade network, they were found to have a disproportionately strong influence on disease transmission dynamics. These findings suggest that targeting extension services at herds with suboptimal performance may be an effective strategy for controlling endemic cattle diseases while simultaneously improving industry productivity. PMID:24671129

  20. Lean business model and implementation of a geriatric fracture center.

    PubMed

    Kates, Stephen L

    2014-05-01

    Geriatric hip fracture is a common event associated with high costs of care and often with suboptimal outcomes for the patients. Ideally, a new care model to manage geriatric hip fractures would address both quality and safety of patient care as well as the need for reduced costs of care. The geriatric fracture center model of care is one such model reported to improve both outcomes and quality of care. It is a lean business model applied to medicine. This article describes basic lean business concepts applied to geriatric fracture care and information needed to successfully implement a geriatric fracture center. It is written to assist physicians and surgeons in their efforts to implement an improved care model for their patients.

  1. Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac.

    PubMed

    Bobe, Gerd; Wang, Bing; Seeram, Navindra P; Nair, Muraleedharan G; Bourquin, Leslie D

    2006-12-13

    A promising approach for cancer chemoprevention might be a combination therapy utilizing dietary phytochemicals and anticarcinogenic pharmaceuticals at a suboptimal dosage to minimize any potential adverse side effects. To test this hypothesis, various dosages of anthocyanin-rich tart cherry extract were fed in combination with suboptimal levels of the nonsteroidal anti-inflammatory drug sulindac to APCMin mice for 19 weeks. By the end of the feeding period, fewer mice that were fed the anthocyanin-rich extract in combination with sulindac lost more than 10% of body weight than mice fed sulindac alone. Mice that were fed anthocyanin-rich extract (at any dose) in combination with sulindac had fewer tumors and a smaller total tumor burden (total tumor area per mouse) in the small intestine when compared to mice fed sulindac alone. These results suggest that a dietary combination of tart cherry anthocyanins and sulindac is more protective against colon cancer than sulindac alone.

  2. The base rate of suboptimal effort in a pediatric mild TBI sample: performance on the Medical Symptom Validity Test.

    PubMed

    Kirkwood, Michael W; Kirk, John W

    2010-01-01

    Performance on the Medical Symptom Validity Test (MSVT) was examined in 193 consecutively referred patients aged 8 through 17 years who had sustained a mild traumatic brain injury. A total of 33 participants failed to meet actuarial criteria for valid effort on the MSVT. After accounting for possible false positives and false negatives, the base rate of suboptimal effort in this clinical sample was 17%. Only one MSVT failure was thought to be influenced by litigation. The present results suggest that a sizable minority of children is capable of putting forth suboptimal effort during neuropsychological exam, even when external incentives are not readily apparent. The MSVT appears to have good potential value as an objective measure for detecting symptom invalidity in school-age youth.

  3. Interpreting Abstract Interpretations in Membership Equational Logic

    NASA Technical Reports Server (NTRS)

    Fischer, Bernd; Rosu, Grigore

    2001-01-01

    We present a logical framework in which abstract interpretations can be naturally specified and then verified. Our approach is based on membership equational logic which extends equational logics by membership axioms, asserting that a term has a certain sort. We represent an abstract interpretation as a membership equational logic specification, usually as an overloaded order-sorted signature with membership axioms. It turns out that, for any term, its least sort over this specification corresponds to its most concrete abstract value. Maude implements membership equational logic and provides mechanisms to calculate the least sort of a term efficiently. We first show how Maude can be used to get prototyping of abstract interpretations "for free." Building on the meta-logic facilities of Maude, we further develop a tool that automatically checks and abstract interpretation against a set of user-defined properties. This can be used to select an appropriate abstract interpretation, to characterize the specified loss of information during abstraction, and to compare different abstractions with each other.

  4. Coping with sub-optimal water temperature: modifications in fatty acid profile of barramundi as influenced by dietary lipid.

    PubMed

    Alhazzaa, Ramez; Bridle, Andrew R; Nichols, Peter D; Carter, Chris G

    2013-06-01

    Metabolic responses to sub-optimal temperature deplete lipid depots, remodel membrane lipid and alter the fatty acid profile in the whole body and tissues of ectothermic vertebrates including fish. The magnitude of these changes may depend on dietary history including oil sources with different fatty acid compositions. Barramundi, Lates calcarifer (Perciformes, Latidae), a tropical ectothermic fish, was fed on diets either rich in dietary long-chain (≥C(20)) polyunsaturated fatty acids (LC-PUFA) from fish oil, rich in stearidonic and γ-linolenic acid (SDA and GLA, respectively) from Echium plantagineum, or rapeseed oil deficient in LC-PUFA. Following 5 weeks at the optimum temperature of 30 °C when growth rates were comparable amongst dietary treatments, water temperature was dropped to 20 °C for 1 week for half of the animals and maintained at 30 °C for the other half. Decreased temperature increased the liver and skeletal muscle content of LC-PUFA in fish fed on echium oil compared with rapeseed oil, while dietary LC-PUFA depots in fish oil fed-fish depleted rapidly in the week of sub-optimal temperature. The lipid unsaturation index of cellular membrane in the liver and muscle increased under low temperature at the same rate regardless of dietary oil. Therefore, rapid exposure of an ectothermic vertebrate to a lower and sub-optimal temperature caused significant modulation in fatty acid composition. We propose that the tolerance of barramundi, a representative of tropical farmed fish, to sub-optimal temperature will be enhanced when fatty acid substrates closer to the LC-PUFA are available in their diet.

  5. High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity.

    PubMed

    Quay, Teo A W; Schroder, Theresa H; Jeruszka-Bielak, Marta; Li, Wangyang; Devlin, Angela M; Barr, Susan I; Lamers, Yvonne

    2015-12-01

    Suboptimal vitamin B12 (B12) status has been associated with an increased risk of congenital anomalies, preterm birth, and childhood insulin resistance. South Asians - Canada's largest minority group - and women of reproductive age are vulnerable to B12 deficiency. This study aimed to assess the prevalence of and factors associated with B12 deficiency and suboptimal B12 status in a convenience sample of young adult women of South Asian and European descent in Metro Vancouver. We measured serum B12, holotranscobalamin, plasma methylmalonic acid, red blood cell and plasma folate, and hematologic parameters in 206 nonpregnant, healthy women aged 19-35 years. Categorization for B12 status adhered to serum B12 cutoffs for deficiency (<148 pmol/L) and suboptimal B12 status (148-220 pmol/L). We collected demographic, lifestyle, and dietary intake data and conducted genotyping for common genetic variants linked to B-vitamin metabolism. The prevalence of deficiency and suboptimal B12 status were 14% and 20%, respectively. Serum vitamin B12 concentrations were negatively associated with oral contraceptive use and first-generation immigrant status, and positively with dietary B12 intake and B12 supplement use. The prevalence of B12 inadequacy in this sample of highly educated women is higher than in the general Canadian population. In light of maternal and fetal health risks associated with B12 inadequacy in early-pregnancy, practitioners should consider monitoring B12 status before and during early pregnancy, especially in immigrants and women with low dietary B12 intakes including non-users of vitamin supplements.

  6. Business-to-business: Buying Recycled.

    ERIC Educational Resources Information Center

    Millberg, Laura

    1994-01-01

    A survey of Minnesota businesses about their efforts to buy recycled content products. Results discuss reactive versus proactive policies, the corporate advantage of environmental protection, how efforts are hampered by confusion, suppliers as key informants, and businesses' need for information. (MDH)

  7. Teaching Business Ethics or Teaching Business Ethically?

    ERIC Educational Resources Information Center

    Stablein, Ralph

    2003-01-01

    Notes that one of the most important contexts for ethical decision-making is the nature and operation of "contemporary capitalisms." Suggests that rather than issuing a call for teaching business ethics, the author emphasizes the need for more ethical business teaching. (SG)

  8. Rectal site and suboptimal nodal yield predict systemic recurrence in resected colorectal carcinoma: a case-control study.

    PubMed

    Hayes, Brian D; O'Riordan, James M; Stuart, Charlotte; Muldoon, Cian

    2014-09-01

    We assessed the contribution of histopathological features to systemic recurrence (SR) in patients with colorectal cancer, using a case-control design: 71 cases and 184 controls were included, with a mean time until SR of 1.4 ± 0.1 years and a mean follow-up of controls of 1.6 ± 0.06 years. Cases had significantly greater odds of rectal site (odds ratio [OR] = 1.82), stage ≥ pT3 (OR = 2.11), suboptimal (<12) lymph node yield (OR = 4.6), stage ≥ pN1 (OR = 2.46), KRAS mutation (OR = 2.76), and extramural venous invasion (OR = 1.97). By multiple regression analysis, rectal site, stage ≥ pT3, suboptimal lymph node yield, and lymph node positivity independently predicted SR. Rectal cancers were more likely to have a suboptimal node yield than nonrectal cancers (relative risk = 1.6) among the entire cohort. We conclude that rectal cancers have greater risk of SR than colon cancers. A lower yield of lymph nodes in rectal cancer specimens may contribute to this.

  9. Sub-optimal presentation of painful facial expressions enhances readiness for action and pain perception following electrocutaneous stimulation

    PubMed Central

    Khatibi, Ali; Schrooten, Martien; Bosmans, Katrien; Volders, Stephanie; Vlaeyen, Johan W.S.; Van den Bussche, Eva

    2015-01-01

    Observation of others’ painful facial expressions has been shown to facilitate behavioral response tendencies and to increase pain perception in the observer. However, in previous studies, expressions were clearly visible to the observer and none of those studies investigated the effect of presence of peripheral stimulation on response tendencies. This study focuses on the effect of sub-optimal presentation of painful facial expressions in the presence and absence of an electrocutaneous stimulus. Twenty-two healthy individuals categorized arrow targets which were preceded by a sub-optimally presented facial expression (painful, happy, or neutral in different blocks). On half of the trials, aversive electrocutaneous stimulation was delivered to the wrist of the non-dominant hand between the presentation of facial expression and target (an arrow directing to right or left). Participants’ task was to indicate direction of the arrow as soon as it appears on the screen by pressing the corresponding key on the keyboard and to rate their pain at the end of block. Analysis showed that responses were faster to targets preceded by aversive stimulation than to targets not preceded by stimulation, especially following painful expressions. Painfulness ratings were higher following painful expressions than following happy expressions. These findings suggest that sub-optimally presented painful expressions can enhance readiness to act to neutral, non-pain-related targets after aversive stimulation and can increase pain perception. PMID:26217260

  10. AGATE animation - business theme

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Business jet 1 of 6. This composite image symbolizes how Advanced General Aviation Transports Experiment (AGATE) technology will contribute to a Small Aircraft Transportation System (SATS) early in the 21st century. Image from AGATE 'business' video animation.

  11. Accessibility versus Accuracy in Retrieving Spatial Memory: Evidence for Suboptimal Assumed Headings

    ERIC Educational Resources Information Center

    Yerramsetti, Ashok; Marchette, Steven A.; Shelton, Amy L.

    2013-01-01

    Orientation dependence in spatial memory has often been interpreted in terms of accessibility: Object locations are encoded relative to a reference orientation that affords the most accurate access to spatial memory. An open question, however, is whether people naturally use this "preferred" orientation whenever recalling the space. We…

  12. Interpreters' Involvement in Multi-Party Interactions: The Nature of Participation as Listener and Speaker

    ERIC Educational Resources Information Center

    Takimoto, Masato

    2012-01-01

    This paper investigates two naturally occurring business interpreting situations where there are a number of participants. Unlike dialogue interpreting situations where there are only two primary interlocutors, the overall interaction shows more complexity in these multi-party situations. This, in turn, means that the interpreters' functions and…

  13. Interpretation biases in paranoia.

    PubMed

    Savulich, George; Freeman, Daniel; Shergill, Sukhi; Yiend, Jenny

    2015-01-01

    Information in the environment is frequently ambiguous in meaning. Emotional ambiguity, such as the stare of a stranger, or the scream of a child, encompasses possible good or bad emotional consequences. Those with elevated vulnerability to affective disorders tend to interpret such material more negatively than those without, a phenomenon known as "negative interpretation bias." In this study we examined the relationship between vulnerability to psychosis, measured by trait paranoia, and interpretation bias. One set of material permitted broadly positive/negative (valenced) interpretations, while another allowed more or less paranoid interpretations, allowing us to also investigate the content specificity of interpretation biases associated with paranoia. Regression analyses (n=70) revealed that trait paranoia, trait anxiety, and cognitive inflexibility predicted paranoid interpretation bias, whereas trait anxiety and cognitive inflexibility predicted negative interpretation bias. In a group comparison those with high levels of trait paranoia were negatively biased in their interpretations of ambiguous information relative to those with low trait paranoia, and this effect was most pronounced for material directly related to paranoid concerns. Together these data suggest that a negative interpretation bias occurs in those with elevated vulnerability to paranoia, and that this bias may be strongest for material matching paranoid beliefs. We conclude that content-specific biases may be important in the cause and maintenance of paranoid symptoms.

  14. Suboptimal Muscle Synergy Activation Patterns Generalize their Motor Function across Postures.

    PubMed

    Sohn, M Hongchul; Ting, Lena H

    2016-01-01

    We used a musculoskeletal model to investigate the possible biomechanical and neural bases of using consistent muscle synergy patterns to produce functional motor outputs across different biomechanical conditions, which we define as generalizability. Experimental studies in cats demonstrate that the same muscle synergies are used during reactive postural responses at widely varying configurations, producing similarly-oriented endpoint force vectors with respect to the limb axis. However, whether generalizability across postures arises due to similar biomechanical properties or to neural selection of a particular muscle activation pattern has not been explicitly tested. Here, we used a detailed cat hindlimb model to explore the set of feasible muscle activation patterns that produce experimental synergy force vectors at a target posture, and tested their generalizability by applying them to different test postures. We used three methods to select candidate muscle activation patterns: (1) randomly-selected feasible muscle activation patterns, (2) optimal muscle activation patterns minimizing muscle effort at a given posture, and (3) generalizable muscle activation patterns that explicitly minimized deviations from experimentally-identified synergy force vectors across all postures. Generalizability was measured by the deviation between the simulated force direction of the candidate muscle activation pattern and the experimental synergy force vectors at the test postures. Force angle deviations were the greatest for the randomly selected feasible muscle activation patterns (e.g., >100°), intermediate for effort-wise optimal muscle activation patterns (e.g., ~20°), and smallest for generalizable muscle activation patterns (e.g., <5°). Generalizable muscle activation patterns were suboptimal in terms of effort, often exceeding 50% of the maximum possible effort (cf. ~5% in minimum-effort muscle activation patterns). The feasible muscle activation ranges of individual

  15. Suboptimal Muscle Synergy Activation Patterns Generalize their Motor Function across Postures

    PubMed Central

    Sohn, M. Hongchul; Ting, Lena H.

    2016-01-01

    We used a musculoskeletal model to investigate the possible biomechanical and neural bases of using consistent muscle synergy patterns to produce functional motor outputs across different biomechanical conditions, which we define as generalizability. Experimental studies in cats demonstrate that the same muscle synergies are used during reactive postural responses at widely varying configurations, producing similarly-oriented endpoint force vectors with respect to the limb axis. However, whether generalizability across postures arises due to similar biomechanical properties or to neural selection of a particular muscle activation pattern has not been explicitly tested. Here, we used a detailed cat hindlimb model to explore the set of feasible muscle activation patterns that produce experimental synergy force vectors at a target posture, and tested their generalizability by applying them to different test postures. We used three methods to select candidate muscle activation patterns: (1) randomly-selected feasible muscle activation patterns, (2) optimal muscle activation patterns minimizing muscle effort at a given posture, and (3) generalizable muscle activation patterns that explicitly minimized deviations from experimentally-identified synergy force vectors across all postures. Generalizability was measured by the deviation between the simulated force direction of the candidate muscle activation pattern and the experimental synergy force vectors at the test postures. Force angle deviations were the greatest for the randomly selected feasible muscle activation patterns (e.g., >100°), intermediate for effort-wise optimal muscle activation patterns (e.g., ~20°), and smallest for generalizable muscle activation patterns (e.g., <5°). Generalizable muscle activation patterns were suboptimal in terms of effort, often exceeding 50% of the maximum possible effort (cf. ~5% in minimum-effort muscle activation patterns). The feasible muscle activation ranges of individual

  16. Business Reengineering - Government Viability

    DTIC Science & Technology

    2000-04-01

    3 EXPLANATION OF THE DOD FRAMEWORK FOR MANAGING PROCESS IMPROVEMENT..... 5 STRATEGIC AND BUSINESS PLANNING PHASE (1...STRATEGIC AND BUSINESS PLANNING PHASE (1): Planning activities analyze the current process baseline benchmarking the current external environment and...these questions to access the status of your organization and its need for reorganization change. Strategic Business Planning " What, if any, change

  17. Small Business Pedagogic Practices

    ERIC Educational Resources Information Center

    Billett, Stephen; Hernon-Tinning, Barnie; Ehrich, Lisa

    2003-01-01

    Understanding how learning for small businesses should best proceed constitutes a worthwhile, yet challenging, pedagogic project. In order to maintain their viability, small businesses need to be able to respond to new practices and tasks. Yet small businesses seem neither attracted to nor to value the kinds of taught courses that are the standard…

  18. Small Business Bibliography.

    ERIC Educational Resources Information Center

    Anderson, Wendell, Ed.

    Intended as a resource for both experienced businesspeople and those new to business, this annotated bibliography provides a list of books, pamphlets, periodicals, and videotapes of value in solving specific business problems. The bibliography begins with a list of resources recommended for the library of every small business and a survey of…

  19. Open for Business.

    ERIC Educational Resources Information Center

    Cutler, Edward

    1984-01-01

    Describes the development and outcomes of Lane Community College's (LCC) Business Assistance Center, which offers a wide range of management assistance services to local small businesses. Explains how state-funded programs, based on the LCC model, resulted in a network of Small Business Development Centers. (CBC)

  20. Food Business Entrepreneurship

    NASA Astrophysics Data System (ADS)

    Weber, Peter

    Though not a very traditional career path for food scientists, one option is to go into business for yourself by starting a food business. Food business entrepreneurship is a difficult career that entails long work hours, extensive decision making, and tasks that require knowledge beyond food science. However, there is high potential for rewards, including financial rewards, career progression, and personal flexibility.

  1. Partnering with Business Coalitions

    ERIC Educational Resources Information Center

    Pawlowski, Brett

    2007-01-01

    Many career and technical education (CTE) programs rely heavily on support from the business community to serve their students. However, there is very little information available on building solid business-education partnerships. Most people in the business world will say that they care about education, but how can educators find the people…

  2. Business English: Curriculum Guide.

    ERIC Educational Resources Information Center

    Montag, Elizabeth J.; Shaw, Warren

    Intended as an English elective subject for senior high school students, this business English course guide provides students with the communication tools that can lead to success in the business world. Units cover the following topics: introduction to Business English (punctuation, grammar, spelling, vocabulary, and use of reference tools);…

  3. The Business Education Curriculum

    ERIC Educational Resources Information Center

    Rader, Martha; Meggison, Peter

    2007-01-01

    The business education curriculum encompasses the educational experiences of business students at all levels. Business education curricula include a variety of programs, courses, units, course objectives, student competencies, assessments, and extracurricular activities that have evolved over the years. Curricula are driven by numerous internal…

  4. Understanding Business Analytics

    DTIC Science & Technology

    2015-01-05

    Business Analytics, Decision Analytics, Business Intelligence, Advanced Analytics, Data Science. . . to a certain degree, to label is to limit - if only... Business Analytics. 2004 2006 2008 2010 2012 2014 Figure 1: Google trending of daily searches for various analytic disciplines “The limits of my

  5. English for Business Communication

    ERIC Educational Resources Information Center

    Bhatia, Vijay K.; Bremner, Stephen

    2012-01-01

    The concept of Business English has undergone some major shifts in the last few years because of a number of developments, such as advances in genre theory and the coming together of English for Business Purposes and Business Communication, inspired by the realization that there is a gap to be bridged between the academy and the globalized…

  6. First Business Guide.

    ERIC Educational Resources Information Center

    Small Business Administration, Washington, DC. Office of Business Development.

    This guide offers first-time business persons information as well as administrative and operational techniques for one-person business enterprises that have low initial start-up costs and low operational and overhead costs. These one-person businesses can be home based or have site locations outside the home. Included in this guide is a list of…

  7. Doing business with NASA

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Because many U.S. businesses and companies want to do business with NASA, the Agency sends out procurement specialists to trade shows and conferences and organizes seminars to educate the business public on how to get on procurement lists to become product and service providers to the federal government.

  8. Canadian Business Schools: Going out of Business?

    ERIC Educational Resources Information Center

    Dobni, Dawn; Dobni, Brooke

    1996-01-01

    Using Porter's five-forces model (potential entrants, suppliers, buyers, rivalry, substitutes) to analyze competition in Canadian university business schools, the authors conclude that schools are becoming increasingly vulnerable to competitive pressures and that strategic reorientation is necessary. (SK)

  9. Higher Education Interpreting.

    ERIC Educational Resources Information Center

    Woll, Bencie; Porcari li Destri, Giulia

    This paper discusses issues related to the training and provision of interpreters for deaf students at institutions of higher education in the United Kingdom. Background information provided notes the increasing numbers of deaf and partially hearing students, the existence of funding to pay for interpreters, and trends in the availability of…

  10. Working with Educational Interpreters.

    ERIC Educational Resources Information Center

    Seal, Brenda C.

    2000-01-01

    This article addresses the mutual needs of speech-language pathologists and educational interpreters in providing services to their students. Guidelines supported by recent research reports and survey data collected from interpreters are offered to speech-language pathologists as ways to improve the working relationship with educational…

  11. 76 FR 8221 - Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... February 11, 2011 Part VII Small Business Administration 13 CFR Parts 121 and 124 Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status Determinations; Final Rule #0;#0... BUSINESS ADMINISTRATION 13 CFR Parts 121 and 124 RIN 3245-AF53 Small Business Size Regulations;...

  12. Does Increasing Treatment Frequency Address Suboptimal Responses to Ivermectin for the Control and Elimination of River Blindness?

    PubMed Central

    Frempong, Kwadwo K.; Walker, Martin; Cheke, Robert A.; Tetevi, Edward Jenner; Gyan, Ernest Tawiah; Owusu, Ebenezer O.; Wilson, Michael D.; Boakye, Daniel A.; Taylor, Mark J.; Biritwum, Nana-Kwadwo; Osei-Atweneboana, Mike; Basáñez, María-Gloria

    2016-01-01

    Background. Several African countries have adopted a biannual ivermectin distribution strategy in some foci to control and eliminate onchocerciasis. In 2010, the Ghana Health Service started biannual distribution to combat transmission hotspots and suboptimal responses to treatment. We assessed the epidemiological impact of the first 3 years of this strategy and quantified responses to ivermectin over 2 consecutive rounds of treatment in 10 sentinel communities. Methods. We evaluated Onchocerca volvulus community microfilarial intensity and prevalence in persons aged ≥20 years before the first, second, and fifth (or sixth) biannual treatment rounds using skin snip data from 956 participants. We used longitudinal regression modeling to estimate rates of microfilarial repopulation of the skin in a cohort of 217 participants who were followed up over the first 2 rounds of biannual treatment. Results. Biannual treatment has had a positive impact, with substantial reductions in infection intensity after 4 or 5 rounds in most communities. We identified 3 communities—all having been previously recognized as responding suboptimally to ivermectin—with statistically significantly high microfilarial repopulation rates. We did not find any clear association between microfilarial repopulation rate and the number of years of prior intervention, coverage, or the community level of infection. Conclusions. The strategy of biannual ivermectin treatment in Ghana has reduced O. volvulus microfilarial intensity and prevalence, but suboptimal responses to treatment remain evident in a number of previously and consistently implicated communities. Whether increasing the frequency of treatment will be sufficient to meet the World Health Organization's 2020 elimination goals remains uncertain. PMID:27001801

  13. Suboptimal CT pulmonary angiography in the emergency department: a retrospective analysis of outcomes in a large academic medical center.

    PubMed

    Bates, David D B; Tkacz, Jaroslaw N; LeBedis, Christina A; Holalkere, Nagaraj

    2016-12-01

    Optimal CT pulmonary angiography (CTPA) is a prerequisite for accurate diagnosis and management of suspected venous thromboembolic disease (VTE) in the emergency department (ED). However, a certain proportion of CTPA studies are diagnostically limited or non-diagnostic due to various technical causes. In this study, we analyze the incidence and cause of suboptimal CTPA studies in the ED and assess the need for additional imaging. Reports of 1444 consecutive CTPAs performed in an ED on adult patients over a 25-month period beginning November 30, 2011, were reviewed. The observed suboptimal CTPA rate was 4.2 % (60/1444). The most common causes of limited or non-diagnostic CTPA in the ED were related to timing of contrast bolus or IV infiltration (26/60, 43.4 %), respiratory motion (16/60, 26.7 %), multifactorial causes (10/60, 16.7 %), and patient motion (8/60, 13.3 %). Of the 60 studies included, only 7 patients (11.7 %) underwent additional diagnostic imaging during the same hospital visit for VTE, while 3 patients (5.0 %) underwent additional imaging for suspected VTE over the next 2 months. A total of 2/60 (3.4 %) patients had documented acute PE on additional imaging performed either on the same hospital visit or within 2 months. Regardless of the factors contributing to suboptimal CTPA, only a very small proportion of patients receive additional imaging to evaluate for VTE, either on the same visit or during the next 2 months (16.7 %, 10/60 patients). A small number (3.4 %) of these patients have documented acute PE within 2 months when additional imaging tests were performed.

  14. Impact of suboptimal breastfeeding on the healthcare and mortality costs of necrotizing enterocolitis in extremely low birthweight infants

    PubMed Central

    Colaizy, Tarah T.; Bartick, Melissa C.; Jegier, Briana J.; Green, Brittany D.; Reinhold, Arnold G.; Schaefer, Andrew J.; Bogen, Debra L.; Schwarz, Eleanor Bimla; Stuebe, Alison M.

    2017-01-01

    Objective To estimate risk of NEC for ELBW infants as a function of preterm formula and maternal milk (MM) intake and calculate the impact of suboptimal feeding on NEC incidence and costs. Design We used adjusted odds ratios (aORs) derived from the Glutamine Trial to perform Monte Carlo simulation of a cohort of ELBW infants under current suboptimal feeding practices, compared to a theoretical cohort in which 90% of infants received at least 98% MM. Results NEC incidence among infants receiving ≥98% MM was 1.3%; 11.1% among infants fed only preterm formula; and 8.2% among infants fed a mixed diet (p=0.002). In adjusted models, compared with infants fed predominantly MM, we found an increased risk of NEC associated with exclusive preterm formula (aOR=12.1, 95% CI 1.5, 94.2), or a mixed diet (aOR 8.7, 95% CI 1.2-65.2). In Monte Carlo simulation, current feeding of ELBW infants was associated with 928 excess NEC cases and 121 excess deaths annually, compared with a model in which 90% of infants received ≥ 98% MM. These models estimated an annual cost of suboptimal feeding of ELBW infants of $27.1 million (CI $24million, $30.4 million) in direct medical costs, $563,655 (CI $476,191, $599,069) in indirect nonmedical costs, and $1.5 billion (CI $1.3 billion, $1.6 billion) in cost attributable to premature death. Conclusions Among ELBW infants, not being fed predominantly MM is associated with an increased risk of NEC. Efforts to support milk production by mothers of ELBW infants may prevent infant deaths and reduce costs. PMID:27131403

  15. Patient compliance and suboptimal bowel preparation with split-dose bowel regimen in average-risk screening colonoscopy

    PubMed Central

    Menees, Stacy B.; Kim, H. Myra; Wren, Patricia; Zikmund-Fisher, Brian J.; Elta, Grace H.; Foster, Stephanie; Korsnes, Sheryl; Graustein, Brittany; Schoenfeld, Philip

    2014-01-01

    Background Although split-dose bowel regimen is recommended in colon cancer screening and surveillance guidelines, implementation in clinical practice has seemingly lagged because of concerns of patient compliance. Objectives To assess patient compliance with the split-dose bowel regimen and assess patient- and preparation process–related factors associated with compliance and bowel preparation adequacy. Design Prospective survey cohort. Setting Tertiary care setting. Patients Average-risk patients undergoing colonoscopy for colorectal cancer screening between August 2011 and January 2013. Main Outcome Measurements Split-dose bowel regimen patient-reported compliance and bowel preparation adequacy with the Boston Bowel Preparation Scale score. Results Surveys and Boston Bowel Preparation Scale score data were completed in 462 participants; 15.4% were noncompliant with the split-dose bowel regimen, and suboptimal bowel preparation (score < 5) was reported in 16% of all procedures. White (P = .009) and married (P = .01) subjects were least likely to be noncompliant, whereas Hispanic subjects and those who reported incomes of US$75,000 or less were most likely to be noncompliant (P = .004). Participants who were noncompliant with split-dosing were less likely to follow the other laxative instructions and more likely to have their colonoscopy appointment before 10:30 am. Compliance differed by bowel preparation type (P = .003, χ2 test), with those who used MiraLAX showing the highest compliance, followed by polyethylene glycol electrolyte solution and other bowel preparations. Noncompliance with split-dose bowel preparation (odds ratio 6.7; 95% confidence interval, 3.2–14.2) was the strongest predictor of suboptimal bowel preparation. Limitations Patient self-report, performed at tertiary care center. Conclusions Overall, 1 in 7 patients do not comply with a split-dose bowel regimen. Ensuring compliance with the split-dose bowel regimen will reduce the risk of a

  16. Adjustment of Eculizumab Dosage Pattern in Patients with Atypical Hemolytic Uremic Syndrome with Suboptimal Response to Standard Treatment Pattern

    PubMed Central

    Peralta Roselló, Carmen; Baltar Martín, José María; Castillo Eraso, Lorena; de Álvaro Moreno, Fernando; Martínez Vea, Alberto; Visus-Fernández de Manzanos, María Teresa

    2016-01-01

    In patients with atypical hemolytic uremic syndrome (aHUS), complement blocking by eculizumab rapidly halts the process of thrombotic microangiopathy and it is associated with clear long-term hematologic and renal improvements. Eculizumab treatment consists of a 4-week initial phase with weekly IV administration of 900 mg doses, followed by a maintenance phase with a 1,200 mg dose in the fifth week and every 14 ± 2 days thereafter. We present three patients with aHUS and suboptimal response to eculizumab treatment at the usual administration dosage who showed hematologic and renal improvements after an adjustment in the eculizumab treatment protocol. PMID:28025630

  17. Theory Interpretations in PVS

    NASA Technical Reports Server (NTRS)

    Owre, Sam; Shankar, Natarajan; Butler, Ricky W. (Technical Monitor)

    2001-01-01

    The purpose of this task was to provide a mechanism for theory interpretations in a prototype verification system (PVS) so that it is possible to demonstrate the consistency of a theory by exhibiting an interpretation that validates the axioms. The mechanization makes it possible to show that one collection of theories is correctly interpreted by another collection of theories under a user-specified interpretation for the uninterpreted types and constants. A theory instance is generated and imported, while the axiom instances are generated as proof obligations to ensure that the interpretation is valid. Interpretations can be used to show that an implementation is a correct refinement of a specification, that an axiomatically defined specification is consistent, or that a axiomatically defined specification captures its intended models. In addition, the theory parameter mechanism has been extended with a notion of theory as parameter so that a theory instance can be given as an actual parameter to an imported theory. Theory interpretations can thus be used to refine an abstract specification or to demonstrate the consistency of an axiomatic theory. In this report we describe the mechanism in detail. This extension is a part of PVS version 3.0, which will be publicly released in mid-2001.

  18. Working With Educational Interpreters.

    PubMed

    Seal, Brenda C

    2000-01-01

    Increasing numbers of students who are deaf or hard of hearing are being educated in their local schools. Accommodations frequently made for these students include the provision of educational interpreting services. Educational interpreters serve to equalize the source language or source communication mode (usually spoken English) with a target language or target mode (either sign language, cued speech, or oral transliterating). Educational interpreters' expertise in sign language or cued speech will likely exceed that of speech-language pathologists, whose expertise in speech and language development and in discourse demands of the classroom will likely exceed that of the educational interpreters. This article addresses the mutual needs of speech-language pathologists and educational interpreters in providing services to their students. Guidelines supported by recent research reports and survey data collected from interpreters are offered to speech-language pathologists as ways to improve the working relationships with educational interpreters in three areas: (a) evaluating a student's communication skills, (b) establishing treatment goals and intervening to meet those goals, and

  19. Why business models matter.

    PubMed

    Magretta, Joan

    2002-05-01

    "Business model" was one of the great buzz-words of the Internet boom. A company didn't need a strategy, a special competence, or even any customers--all it needed was a Web-based business model that promised wild profits in some distant, ill-defined future. Many people--investors, entrepreneurs, and executives alike--fell for the fantasy and got burned. And as the inevitable counterreaction played out, the concept of the business model fell out of fashion nearly as quickly as the .com appendage itself. That's a shame. As Joan Magretta explains, a good business model remains essential to every successful organization, whether it's a new venture or an established player. To help managers apply the concept successfully, she defines what a business model is and how it complements a smart competitive strategy. Business models are, at heart, stories that explain how enterprises work. Like a good story, a robust business model contains precisely delineated characters, plausible motivations, and a plot that turns on an insight about value. It answers certain questions: Who is the customer? How do we make money? What underlying economic logic explains how we can deliver value to customers at an appropriate cost? Every viable organization is built on a sound business model, but a business model isn't a strategy, even though many people use the terms interchangeably. Business models describe, as a system, how the pieces of a business fit together. But they don't factor in one critical dimension of performance: competition. That's the job of strategy. Illustrated with examples from companies like American Express, EuroDisney, WalMart, and Dell Computer, this article clarifies the concepts of business models and strategy, which are fundamental to every company's performance.

  20. Small Business Procurement Event

    DTIC Science & Technology

    2014-08-13

    Small Business Procurement Event 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...distribution unlimited 13. SUPPLEMENTARY NOTES NDIA 27th Navy Gold Coast Small Business Procurement Event , 12-13 Aug 2014, San Diego, CA. 14. ABSTRACT...18 Target the Small Business Accessible Market within the Department of the Navy $77.8B Department of the Navy Total SB Eligible Spend

  1. Negotiating Diversity: Fostering Collaborative Interpretations of Case Studies

    ERIC Educational Resources Information Center

    Guo, Shujie; Cockburn-Wootten, Cheryl; Munshi, Debashish

    2014-01-01

    The intercultural divides in values, perceptions, and interpretations of concepts have been studied extensively by international business and intercultural communication scholars. Consequentially, much effort in university classrooms is spent on focusing on the differences between groups and on finding ways to "manage" cultural…

  2. Programs for Training Interpreters.

    ERIC Educational Resources Information Center

    American Annals of the Deaf, 2003

    2003-01-01

    This listing provides directory information on U.S. programs for training interpreters for individuals with deafness. Schools are listed by state and include director and degree information. (Author/CR)

  3. Interpreting the X(5568)

    NASA Astrophysics Data System (ADS)

    Burns, T. J.; Swanson, E. S.

    2016-09-01

    A variety of options for interpreting the DØ state, X (5568), are examined. We find that threshold, cusp, molecular, and tetraquark models are all unfavoured. Several experimental tests for unravelling the nature of the signal are suggested.

  4. Interpretation of dental radiographs.

    PubMed

    Woodward, Tony M

    2009-02-01

    Interpretation of dental radiographs is fairly straightforward, with a handful of common patterns making up the majority of pathology. This article covers normal radiographic anatomy, endodontic disease, periodontal disease, neoplastic changes, tooth resorption, caries, and radiographic signs of oral trauma.

  5. Polysomnography methods and interpretations.

    PubMed

    Rundell, O H; Jones, R K

    1990-08-01

    As the field of sleep disorders medicine continues to mature, appropriate diagnostic techniques are becoming properly defined and standardized. This article focuses principally upon diagnostic testing for sleep apnea, although other sleep disorders are discussed briefly. When interpreting a polysomnogram, one must consider a number of complex variables. A critical discussion of the methods for adequately measuring these variables is provided together with guidelines for appropriate interpretation.

  6. Interpreter-mediated dentistry.

    PubMed

    Bridges, Susan; Drew, Paul; Zayts, Olga; McGrath, Colman; Yiu, Cynthia K Y; Wong, H M; Au, T K F

    2015-05-01

    The global movements of healthcare professionals and patient populations have increased the complexities of medical interactions at the point of service. This study examines interpreter mediated talk in cross-cultural general dentistry in Hong Kong where assisting para-professionals, in this case bilingual or multilingual Dental Surgery Assistants (DSAs), perform the dual capabilities of clinical assistant and interpreter. An initial language use survey was conducted with Polyclinic DSAs (n = 41) using a logbook approach to provide self-report data on language use in clinics. Frequencies of mean scores using a 10-point visual analogue scale (VAS) indicated that the majority of DSAs spoke mainly Cantonese in clinics and interpreted for postgraduates and professors. Conversation Analysis (CA) examined recipient design across a corpus (n = 23) of video-recorded review consultations between non-Cantonese speaking expatriate dentists and their Cantonese L1 patients. Three patterns of mediated interpreting indicated were: dentist designated expansions; dentist initiated interpretations; and assistant initiated interpretations to both the dentist and patient. The third, rather than being perceived as negative, was found to be framed either in response to patient difficulties or within the specific task routines of general dentistry. The findings illustrate trends in dentistry towards personalized care and patient empowerment as a reaction to product delivery approaches to patient management. Implications are indicated for both treatment adherence and the education of dental professionals.

  7. The relationship between suboptimal effort and post-concussion symptoms in children and adolescents with mild traumatic brain injury.

    PubMed

    Araujo, Gabriel C; Antonini, Tanya N; Monahan, Kerry; Gelfius, Carl; Klamar, Karl; Potts, Michelle; Yeates, Keith O; Bodin, Doug

    2014-01-01

    This retrospective chart review study explored the relationship between suboptimal effort and post-concussion symptoms in pediatric mild traumatic brain injury (mTBI). Participants were 382 clinically referred children and adolescents between 8 and 16 years of age who sustained an mTBI. Suboptimal effort was identified using reliable digit span and age-corrected scaled scores from the Numbers subtest of the Children's Memory Scale (CMS); 20% of the sample were classified as non-credible performers. Chi-square analyses and t-tests were used to examine differences in post-concussion symptoms and neuropsychological test performance between credible and non-credible performers. Linear regression was used to examine whether CMS Numbers performance predicted post-concussion symptoms after controlling for baseline symptoms and other relevant demographic- and injury-related factors. We found that non-credible performers presented with a greater number of post-concussion symptoms as compared with credible performers. Additionally, non-credible performers demonstrated comparatively poorer performance on neuropsychological tests of focused attention and processing speed. These results suggest that children and adolescents with mTBI who fail effort testing might have a greater tendency to exaggerate post-concussion symptoms and cognitive impairment. The clinical implications of these findings are discussed.

  8. Suboptimal implementation of diagnostic algorithms and overuse of computed tomography-pulmonary angiography in patients with suspected pulmonary embolism

    PubMed Central

    Alhassan, Sulaiman; Sayf, Alaa Abu; Arsene, Camelia; Krayem, Hicham

    2016-01-01

    BACKGROUND: Majority of our computed tomography-pulmonary angiography (CTPA) scans report negative findings. We hypothesized that suboptimal reliance on diagnostic algorithms contributes to apparent overuse of this test. METHODS: A retrospective review was performed on 2031 CTPA cases in a large hospital system. Investigators retrospectively calculated pretest probability (PTP). Use of CTPA was considered as inappropriate when it was ordered for patients with low PTP without checking D-dimer (DD) or following negative DD. RESULTS: Among the 2031 cases, pulmonary embolism (PE) was found in 7.4% (151 cases). About 1784 patients (88%) were considered “PE unlikely” based on Wells score. Out of those patients, 1084 cases (61%) did not have DD test prior to CTPA. In addition, 78 patients with negative DD underwent unnecessary CTPA; none of them had PE. CONCLUSIONS: The suboptimal implementation of PTP assessment tools can result in the overuse of CTPA, contributing to ineffective utilization of hospital resources, increased cost, and potential harm to patients. PMID:27803751

  9. Observations of simple RNA suboptimal structures including pseudoknots suggests that the folding landscape is often funnel shaped

    NASA Astrophysics Data System (ADS)

    Dawson, Wayne; Kawai, Gota

    2008-03-01

    Many RNA structure are known to fold up into complex function structures such as ribosomal RNA, transfer RNA (tRNA), riboswitches, etc. We are currently developing a novel theoretical approach for predicting the base pairing topology of folded RNA structures [1,2], a term known as RNA secondary structure. A good prediction of this base pairing can significantly speed up computation of the full 3D structure of these complex molecules. In recent work, we reported a pseudoknot prediction application using this model [3]. We have now upgraded this application to also predict suboptimal structures. The results of this model suggest that structures like tRNA often have a folding landscape of suboptimal structures that is essentially funnel shaped; similar to what is known to be the case for many simple proteins. This model has also been applied to simple protein structure topology prediction in a similar fashion. [1] Dawson, et al. (2001). J Theor Biol. 213, 359-386 and 387-412. [2] Dawson, et al. (2006). Nucleosides, Nucleotides, and Nucleic Acids 25, 171-189. [3]Dawson, et al. (2007). PLoS One, 2, 905.

  10. Gendered Discourse about Family Business

    ERIC Educational Resources Information Center

    Danes, Sharon M.; Haberman, Heather R.; McTavish, Donald

    2005-01-01

    Language patterns of family business owners were explored by identifying discourse styles and emphasized ideas in four presenting contexts: business, family, intersection of family and business, and business success. The content analysis supports the existence of a general discourse style within family businesses and of similarities and…

  11. Business Economics Courses for Business Students: A Note.

    ERIC Educational Resources Information Center

    Douglas, Evan J.

    1979-01-01

    Suggests that business students should be offered business-related economics courses on subjects such as managerial economics and business conditions analysis. Philosophy and content of these courses are suggested. (DB)

  12. Learning About Business.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Center for Vocational and Technical Education.

    In the teacher's guide, learning experiences focus on helping students in primary grades develop their understanding of the interrelationships among businesses, workers, and families through examinations of local stores and businesses and of the workers who work in them. Students are given the opportunity to acquire economical awareness and…

  13. Teaching Business Italian.

    ERIC Educational Resources Information Center

    Trivelli, Remo J.

    The University of Rhode Island's business Italian course is an advanced language course whose focus is the Italian business world and its reflection of values, customs, and traditions. The course begins with presentations on salient features of contemporary Italian, such as syntactical simplification and nominalization, and how the social,…

  14. Business Schools at Risk.

    ERIC Educational Resources Information Center

    BizEd, 2002

    2002-01-01

    Explores pervasive forces, such as faculty shortages, pressures to enhance curricular relevance, and intense, worldwide competition, that are threatening traditional business schools. Describes recommendations reached by the Management Education Task Force formed by the Association to Advance Collegiate Schools of Business, which addressed these…

  15. IBM Small Business Survey.

    ERIC Educational Resources Information Center

    International Business Machines Corp., Armonk, NY.

    A telephone survey conducted March 15-22, 1991, examined how small businesses are currently performing. Interviewees were 400 small business owners randomly selected from a Dun and Bradstreet list of companies with 50 or fewer employees. Major findings were as follows: (1) owners were survivors, highly confident in their own abilities, and…

  16. Teaching Business Online

    ERIC Educational Resources Information Center

    MacKillop, Robyn

    2010-01-01

    Business is integral to the functioning of the national economy, politics, education and everyday living. It is without question that business education is a vital part of the high school experience, and should be seen as required courses rather than electives. Preparing high school students for real life beyond high school happens in the business…

  17. Business Communication in BELF

    ERIC Educational Resources Information Center

    Kankaanranta, Anne; Louhiala-Salminen, Leena

    2007-01-01

    The authors' business communication perspective is not in fact that of ESL but rather English as a foreign language (EFL) or, even more so, English as a lingua franca (ELF). To be more specific, they would like to add one more acronym to the list: They teach BELF, by which they refer to ELF for business communication purposes. The authors work as…

  18. The Business of Life.

    ERIC Educational Resources Information Center

    Dunski, Jonathan F.

    1997-01-01

    Describes a learning game called The Business of Life that demonstrates the cellular processes of photosynthesis and respiration as business transactions. Incorporates the ideas that energy flows through ecosystems as well as through cells of individual organisms. Demonstrates the interdependence of living things and that processes at the cellular…

  19. School Business Administration.

    ERIC Educational Resources Information Center

    Jordan, K. Forbis; And Others

    This textbook reviews the principal concerns within each of 13 major responsibility areas in school business administration. The first chapter assesses the political, social, and economic context in which schools function and school administrators work. The role and function of the school business administrator within this context is addressed in…

  20. Selective Lessons from Business

    ERIC Educational Resources Information Center

    Schlechty, Phillip C.

    2008-01-01

    Over the years, the author has participated in many gatherings where business leaders have been invited to provide educational leaders with advice regarding the way they should lead their schools. Some of these events proved satisfying, but others proved disastrous. In this article, the author argues that it is a mistake to invite business leaders…

  1. Social enterprise. Risky business.

    PubMed

    2007-02-15

    The skills needed to run a social enterprise are similar to those needed for conventional business. Accounts for social enterprises will have a 'double bottom line', showing social benefit as well as profit. Finding a good mentor is vital, as is setting out a clear vision and values in your business plan.

  2. Agriculture Business and Management.

    ERIC Educational Resources Information Center

    Seperich, George; And Others

    This curriculum guide is intended for vocational agriculture teachers who deliver agricultural business and management programs at the secondary or postsecondary level. It is based on the Arizona validated occupational competencies and tasks for management and supervisory positions in agricultural business. The competency/skill and task list…

  3. International Business Studies.

    ERIC Educational Resources Information Center

    Hendon, Donald W.

    The new International Business major within the School of Business, begun in fall 1989, is an ongoing, enriched program for highly motivated students of above-average scholastic achievement. Its primary purposes are to (1) prepare students to understand America's trading partners and (2) teach the technical knowledge needed in an international…

  4. Business Games Handbook.

    ERIC Educational Resources Information Center

    Graham, Robert G.; Gray, Clifford F.

    The aim of this handbook is to provide training directors and all others interested in business games with an organized listing and description of business games and their sources; and to provide a source of sufficient data to help them select games for a particular purpose. The games are categorized as general purpose games, used in management…

  5. General Business 101.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg.

    This teaching guide contains guidelines for conducting a secondary-level general business course. Intended to serve as an introduction to business and consumer fundamentals, the course provides socioeconomic background useful to students seeking vocational preparation for office and clerical occupations. The goals and objectives of the course are…

  6. Building Tomorrow's Business Today

    ERIC Educational Resources Information Center

    Ryan, Jim

    2010-01-01

    Modern automobile maintenance, like most skilled-trades jobs, is more than simple nuts and bolts. Today, skilled-trades jobs might mean hydraulics, computerized monitoring equipment, electronic blueprints, even lasers. As chief executive officer of Grainger, a business-to-business maintenance, repair, and operating supplies company that…

  7. Defining Business English.

    ERIC Educational Resources Information Center

    Pickett, G. D.

    Business language is directed both outward, toward the general public and inward, toward the particular type of business. In the first instance, it approximates lay language and has contributed some expressions to common usage. In the second instance, it departs from lay language and becomes specialized within each industry, sometimes to the point…

  8. Personal Achievement Reading: Business.

    ERIC Educational Resources Information Center

    Swinton, Janet R.

    Exercises are provided in this set of four workbooks designed to aid students in business programs in building vocabulary and reading skills. Each workbook borrows from business terminology to provide explanations and exercises for a sequential series of instructional objectives. One workbook concentrates on developing the ability to determine…

  9. Microcomputers in Business Education.

    ERIC Educational Resources Information Center

    Muscat, Eugene

    1980-01-01

    This article acquaints business educators with the equipment, terminology, and the wide range of applications microcomputers have in business education programs. Areas examined include hardware, software, computer-assisted instruction (drill and practice, simulation, and tutorial), computer-managed instruction, and word processing. (CT)

  10. Considerations When Working with Interpreters.

    ERIC Educational Resources Information Center

    Hwa-Froelich, Deborah A.; Westby, Carol E.

    2003-01-01

    This article describes the current training and certification procedures in place for linguistic interpreters, the continuum of interpreter roles, and how interpreters' perspectives may influence the interpretive interaction. The specific skills needed for interpreting in either health care or educational settings are identified. A table compares…

  11. 75 FR 1296 - Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION 13 CFR Parts 121 and 124 Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status Determinations AGENCY: U.S. Small Business Administration. ACTION: Notice...

  12. 77 FR 28237 - Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... / Monday, May 14, 2012 / Rules and Regulations#0;#0; ] SMALL BUSINESS ADMINISTRATION 13 CFR Part 124 RIN 3245-AF53 Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status Determinations; Correction AGENCY: U.S. Small Business Administration. ACTION:...

  13. Business Communications Students Demonstrate Realistic Business Practices.

    ERIC Educational Resources Information Center

    Lehman, Carol M.

    1987-01-01

    Suggests that business communication students can improve their management and communications skills by forming teams and playing the roles of corporate employees, including holding stockholders' meetings, drawing up reports, discussing new products, and in general honing their professional appearance and conduct. (JC)

  14. English through Business and Business through English.

    ERIC Educational Resources Information Center

    Lesley, Tay

    This paper describes a highly specialized ESL program for a group of foreign students at the University of Southern California. The students were foreign graduates in business administration and economics who were entering the MBA program at USC. Previous experience with such students indicated that many entered the program with an insufficient…

  15. Learning Activities for International Business.

    ERIC Educational Resources Information Center

    Haynes, Thomas

    1998-01-01

    The National Standards for Business Education include nine areas relating to international business: awareness, communication, environmental factors, ethics, finance, management, marketing, import/export, and organizational structure of international business. (SK)

  16. Socioeconomic factors explain suboptimal adherence to antiretroviral therapy among HIV-infected Australian adults with viral suppression

    PubMed Central

    Siefried, Krista J.; Mao, Limin; Kerr, Stephen; Cysique, Lucette A.; Gates, Thomas M.; McAllister, John; Maynard, Anthony; de Wit, John; Carr, Andrew

    2017-01-01

    Background Missing more than one tablet of contemporary antiretroviral therapy (ART) per month increases the risk of virological failure. Recent studies evaluating a comprehensive range of potential risk factors for suboptimal adherence are not available for high-income settings. Methods Adults on ART with undetectable viral load (UDVL) were recruited into a national, multi-centre cohort, completing a comprehensive survey assessing demographics, socio-economic indicators, physical health, well-being, life stressors, social supports, HIV disclosure, HIV-related stigma and discrimination, healthcare access, ART regimen, adherence, side effects, costs and treatment beliefs. Baseline data were assessed, and suboptimal adherence was defined as self-reported missing ≥1 ART dose/month over the previous 3-months; associated factors were identified using bivariate and multivariate binary logistic regression. Results We assessed 522 participants (494 [94.5%] men, mean age = 50.8 years, median duration UDVL = 3.3 years [IQR = 1.2–6.8]) at 17 sexual health, hospital, and general practice clinics across Australia. Seventy-eight participants (14.9%) reported missing ≥1 dose/month over the previous three months, which was independently associated with: being Australian-born (AOR [adjusted odds ratio] = 2.4 [95%CI = 1.2–4.9], p = 0.014), not being in a relationship (AOR = 3.3 [95%CI = 1.5–7.3], p = 0.004), reaching the “Medicare safety net” (capping annual medical/pharmaceutical costs) (AOR = 2.2 [95%CI = 1.1–4.5], p = 0.024), living in subsidised housing (AOR = 2.5 [95%CI = 1.0–6.2], p = 0.045), receiving home-care services (AOR = 4.4 [95%CI = 1.0–18.8], p = 0.046), HIV community/outreach services linkage (AOR = 2.4 [95%CI = 1.1–5.4], p = 0.033), and starting ART following self-request (AOR = 3.0 [95%CI = 1.3–7.0], p = 0.012). Conclusions In this population, 15% reported recent suboptimal ART adherence at levels associated in prospective studies with

  17. Traditional Chinese medicine and new concepts of predictive, preventive and personalized medicine in diagnosis and treatment of suboptimal health

    PubMed Central

    2014-01-01

    Background The premise of disease-related phenotypes is the definition of the counterpart normality in medical sciences. Contrary to clinical practices that can be carefully planned according to clinical needs, heterogeneity and uncontrollability is the essence of humans in carrying out health studies. Full characterization of consistent phenotypes that define the general population is the basis to individual difference normalization in personalized medicine. Self-claimed normal status may not represent health because asymptomatic subjects may carry chronic diseases at their early stage, such as cancer, diabetes mellitus and atherosclerosis. Currently, treatments for non-communicable chronic diseases (NCD) are implemented after disease onset, which is a very much delayed approach from the perspective of predictive, preventive and personalized medicine (PPPM). A NCD pandemic will develop and be accompanied by increased global economic burden for healthcare systems throughout both developed and developing countries. This paper examples the characterization of the suboptimal health status (SHS) which represents a new PPPM challenge in a population with ambiguous health complaints such as general weakness, unexplained medical syndrome (UMS), chronic fatigue syndrome (CFS), myalgic encephalomyelitis (ME), post-viral fatigue syndrome (PVFS) and chronic fatigue immune dysfunction syndrome (CFIDS). Methods We applied clinical informatic approaches and developed a questionnaire—suboptimal health status questionnaire-25 (SHSQ-25) for measuring SHS. The validity and reliability of this approach were evaluated in a small pilot study and then in a cross-sectional study of 3,405 participants in China. Results We found a correlation between SHS and systolic blood pressure, diastolic blood pressure, plasma glucose, total cholesterol and high-density lipoprotein (HDL) cholesterol among men, and a correlation between SHS and systolic blood pressure, diastolic blood pressure, total

  18. The ADAMS interactive interpreter

    SciTech Connect

    Rietscha, E.R.

    1990-12-17

    The ADAMS (Advanced DAta Management System) project is exploring next generation database technology. Database management does not follow the usual programming paradigm. Instead, the database dictionary provides an additional name space environment that should be interactively created and tested before writing application code. This document describes the implementation and operation of the ADAMS Interpreter, an interactive interface to the ADAMS data dictionary and runtime system. The Interpreter executes individual statements of the ADAMS Interface Language, providing a fast, interactive mechanism to define and access persistent databases. 5 refs.

  19. Knowledge and Awareness of Familial Hypercholesterolaemia among Registered Medical Practitioners in Tamil Nadu: Are They Suboptimal?

    PubMed Central

    Balasubramanian, Shanthi; Pang, Jing; Watts, Gerald F

    2016-01-01

    Introduction Familial Hypercholesterolaemia (FH) is the most common monogenic disorder causing premature Coronary Artery Disease (CAD). However, the majority of people with FH are undiagnosed and under treated. Aim To determine awareness, knowledge and practices of registered medical practitioners regarding FH in India. Materials and Methods Physicians from a southern state of India (Tamil Nadu) who see the general cases were requested to complete a structured online survey questionnaire based on the outcomes on screening, diagnostic and service aspects of FH. Results A total of 133 physicians were surveyed, 27.9% perceived themselves to have above average familiarity with FH and 71.4% correctly described FH. 41.4% of physicians were unaware and unsure whether they had FH patients under their care. The awareness of specific aspects of FH were as follows: heritability 35.3%, prevalence 31.6%, typical lipid profile 34.6%, CVD relating to FH13.5%, genetic testing 33.1%, cascade screening 41.4%, preventive, management and referral services for FH 12.8%, 49.6% of them thought that the age for screening young people for FH should be 13 to 18 years. 84.2% selected GP’s as the most effective health care provider for the early detection and care of FH as being useful. 69.2% selected interpretive commenting on lipid profile to highlight patients at risk of FH. 91.7% and 19.5% of physicians identified statins as monotherapy and statin with ezetimibe as combination therapy for FH, respectively. Conclusion The study identified substantial deficit in the awareness and knowledge of FH among primary care physicians in Tamil Nadu. Extensive and continuous medical education programs are required to close the gap in coronary prevention. PMID:27437273

  20. Business Use of Satellite Communications.

    ERIC Educational Resources Information Center

    Edelson, Burton I.; Cooper, Robert S.

    1982-01-01

    Reviews business communications development and discusses business applications of satellite communications, system technology, and prospects for future developments in digital transmission systems. (JN)

  1. Nonadaptive methods for polyhedral approximation of the Edgeworth—Pareto hull using suboptimal coverings on the direction sphere

    NASA Astrophysics Data System (ADS)

    Lotov, A. V.; Maiskaya, T. S.

    2012-01-01

    For multicriteria convex optimization problems, new nonadaptive methods are proposed for polyhedral approximation of the multidimensional Edgeworth-Pareto hull (EPH), which is a maximal set having the same Pareto frontier as the set of feasible criteria vectors. The methods are based on evaluating the support function of the EPH for a collection of directions generated by a suboptimal covering on the unit sphere. Such directions are constructed in advance by applying an asymptotically effective adaptive method for the polyhedral approximation of convex compact bodies, namely, by the estimate refinement method. Due to the a priori definition of the directions, the proposed EPH approximation procedure can easily be implemented with parallel computations. Moreover, the use of nonadaptive methods considerably simplifies the organization of EPH approximation on the Internet. Experiments with an applied problem (from 3 to 5 criteria) showed that the methods are fairly similar in characteristics to adaptive methods. Therefore, they can be used in parallel computations and on the Internet.

  2. Deleterious effect of suboptimal diet on rest-activity cycle in Anastrepha ludens manifests itself with age.

    PubMed

    Chiu, Joanna C; Kaub, Kevin; Zou, Sige; Liedo, Pablo; Altamirano-Robles, Leopoldo; Ingram, Donald; Carey, James R

    2013-01-01

    Activity patterns and sleep-wake cycles are among the physiological processes that change most prominently as animals age, and are often good indicators of healthspan. In this study, we used the video-based high-resolution behavioral monitoring system (BMS) to monitor the daily activity cycle of tephritid fruit flies Anastrepha ludens over their lifetime. Surprisingly, there was no dramatic change in activity profile with respect to age if flies were consistently fed with a nutritionally balanced diet. However, if flies were fed with sugar-only diet, their activity profile decreased in amplitude at old age, suggesting that suboptimal diet affected activity patterns, and its detrimental effect may not manifest itself until the animal ages. Moreover, by simulating different modes of behavior monitoring with a range of resolution and comparing the resulting conclusions, we confirmed the superior performance of video-based monitoring using high-resolution BMS in accurately representing activity patterns in an insect model.

  3. Optimal and suboptimal protocols for a mathematical model for tumor anti-angiogenesis in combination with chemotherapy.

    PubMed

    Ledzewicz, Urszula; Maurer, Helmut; Schättler, Heinz

    2011-04-01

    We consider the problem of minimizing the tumor volume with a priori given amounts of anti-angiogenic and cytotoxic agents. For one underlying mathematical model, optimal and suboptimal solutions are given for four versions of this problem: the case when only anti-angiogenic agents are administered, combination treatment with a cytotoxic agent, and when a standard linear pharmacokinetic equation for the anti-angiogenic agent is added to each of these models. It is shown that the solutions to the more complex models naturally build upon the simplified versions. This gives credence to a modeling approach that starts with the analysis of simplified models and then adds increasingly more complex and medically relevant features. Furthermore, for each of the problem formulations considered here, there exist excellent simple piecewise constant controls with a small number of switchings that virtually replicate the optimal values for the objective.

  4. Interpreting & Biomechanics. PEPNet Tipsheet

    ERIC Educational Resources Information Center

    PEPNet-Northeast, 2001

    2001-01-01

    Cumulative trauma disorder (CTD) refers to a collection of disorders associated with nerves, muscles, tendons, bones, and the neurovascular (nerves and related blood vessels) system. CTD symptoms may involve the neck, back, shoulders, arms, wrists, or hands. Interpreters with CTD may experience a variety of symptoms including: pain, joint…

  5. Psychosemantics and Simultaneous Interpretation.

    ERIC Educational Resources Information Center

    Le Ny, Jean-Francois

    A comprehension model of simultaneous interpretation activity raises three types of problems: structure of semantic information stored in long-term memory, modalities of input processing and specific restrictions due to situation. A useful concept of semantic mnesic structures includes: (1) a componential-predicative lexicon; (2) a propositional…

  6. Interpreting the Constitution.

    ERIC Educational Resources Information Center

    Brennan, William J., Jr.

    1987-01-01

    Discusses constitutional interpretations relating to capital punishment and protection of human dignity. Points out the document's effectiveness in creating a new society by adapting its principles to current problems and needs. Considers two views of the Constitution that lead to controversy over the legitimacy of judicial decisions. (PS)

  7. Fractal interpretation of intermittency

    SciTech Connect

    Hwa, R.C.

    1991-12-01

    Implication of intermittency in high-energy collisions is first discussed. Then follows a description of the fractal interpretation of intermittency. A basic quantity with asymptotic fractal behavior is introduced. It is then shown how the factorial moments and the G moments can be expressed in terms of it. The relationship between the intermittency indices and the fractal indices is made explicit.

  8. Comprehensions and Interpretations.

    ERIC Educational Resources Information Center

    Urquhart, Alexander H.

    1987-01-01

    Argues that second-language reading comprehension and its assessment can be usefully divided into two aspects: (1) comprehensions (different levels of comprehension the reader adopts to suit different purposes of reading); and (2) interpretations (different readings of the same text resulting from different background knowledge or preoccupations…

  9. Interpreting Contradictory Communications.

    ERIC Educational Resources Information Center

    Lightfoot, Cynthia

    Preschool children, elementary school students, and adults participated in a study that examined various processes used to interpret contradictory communications. A screening test determined that all subjects were capable of discriminating between contradictory and congruent communications. Subjects were presented with contradictory verbal-facial…

  10. Deafness and Interpreting.

    ERIC Educational Resources Information Center

    New Jersey State Dept. of Labor, Trenton. Div. of the Deaf.

    This paper explains how the hearing loss of deaf persons affects communication, describes methods deaf individuals use to communicate, and addresses the role of interpreters in the communication process. The volume covers: communication methods such as speechreading or lipreading, written notes, gestures, or sign language (American Sign Language,…

  11. Social Maladjustment: An Interpretation.

    ERIC Educational Resources Information Center

    Center, David B.

    The exclusionary term, "social maladjustment," the definition in Public Law 94-142 (the Education for All Handicapped Children Act) of serious emotional disturbance, has been an enigma for special education. This paper attempts to limit the interpretation of social maladjustment in order to counter effects of such decisions as…

  12. Hyperplastic obesity and liver steatosis as long-term consequences of suboptimal in vitro culture of mouse embryos.

    PubMed

    Serrano, Antonia; Decara, Juan M; Fernández-González, Raúl; López-Cardona, Angela P; Pavón, Francisco J; Orio, Laura; Alen, Francisco; Gutiérrez-Adán, Alfonso; de Fonseca, Fernando Rodríguez

    2014-08-01

    In the present study, we identify and describe an obese phenotype in mice as a long-term consequence of a suboptimal in vitro culture that resulted from the addition of fetal calf serum (FCS) into the culture medium. Mice produced with FCS displayed a high mortality rate (approximately 55% versus 15% in control mice within 20 mo) and increased sensitivity to the development of obesity in adulthood when fed either a standard or a high-fat diet. These mice developed hyperplastic obesity that was characterized by a significant expansion of the fat pads (approximately 25% and 32% higher body weight in male and female mice over controls, respectively) with unchanged adipocyte size. We observed a sexual dimorphism in the development of obesity in the mice produced with FCS. Whereas the female mice displayed hypertension, hyperleptinemia, and fatty liver, the male mice only displayed glucose intolerance. The mRNA expression of metabolically relevant genes in the adipose tissue was also affected. The males produced with FCS expressed higher mRNA levels of the genes that activate fatty acid oxidation (peroxisome proliferator-activated receptor alpha [Ppara, PPARalpha] and acyl-CoA oxidase 1 [Acox1, ACOX1]) and thermogenesis (uncoupling protein 1 [Ucp1, UCP1]), which may counteract the metabolic phenotype. Conversely, the females produced with FCS generally expressed lower levels of these metabolic genes. In the females, the obese phenotype was associated with inhibition of the lipogenic pathway (peroxisome proliferator-activated receptor gamma [Pparg, PPARgamma] and fatty acid synthase [Fasn, FAS]), indicating a saturation of the storage capacity of the adipose tissue. Overall, our data indicate that the exposure to suboptimal in vitro culture conditions can lead to the sexually dimorphic development of obesity in adulthood.

  13. Street drugs: everyone's business.

    PubMed

    Su'a, F

    1989-11-01

    In the profession of law enforcement, we see drug abuse as our most serious crime problem. We also realize that simply making arrests, by itself, won't solve the problem. The drug business might be the filthiest business on earth, but it's not a business that forces customers to buy dope. Dope dealers may be ruthless and may even kill, but no one forces anyone to buy drugs at gunpoint. The truth is that drug dealers would go nowhere, were it not for the customers.

  14. Rethinking How Business Purpose Is Taught in Catholic Business Education

    ERIC Educational Resources Information Center

    Johnson, Lyman; Naughton, Michael; Bojan, William

    2013-01-01

    Business education at a Catholic university should engage students and faculty across the university in critically examining the purpose of business in society. Following the best practices of leading business schools, the Catholic business curriculum has mostly focused on the shareholder and stakeholder approaches--with the shareholder approach…

  15. Maintenance Business Plans.

    ERIC Educational Resources Information Center

    Adams, Matt

    2002-01-01

    Discusses maintenance business plans, statements which provide accountability for facilities maintenance organizations' considerable budgets. Discusses the plan's components: statement of plan objectives, macro and detailed description of the facility assets, maintenance function descriptions, description of key performance indicators, milestone…

  16. Business Process Management

    NASA Astrophysics Data System (ADS)

    Mendling, Jan

    The recent progress of Business Process Management (BPM) is reflected by the figures of the related industry. Wintergreen Research estimates that the international market for BPM-related software and services accounted for more than USD 1 billion in 2005 with a tendency towards rapid growth in the subsequent couple of years [457]. The relevance of business process modeling to general management initiatives has been previously studied in the 1990s [28]. Today, Gartner finds that organizations that had the best results in implementing business process management spent more than 40 percent of the total project time on discovery and construction of their initial process model [265]. As a consequence, Gartner considers Business Process Modeling to be among the Top 10 Strategic Technologies for 2008.

  17. Business Continuity Management Plan

    DTIC Science & Technology

    2014-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT BUSINESS CONTINUITY MANAGEMENT PLAN December 2014...Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget...

  18. AGATE animation - business theme

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Business jet 6 of 6. Advanced General Aviation Technology Experiment (AGATE). The General Aviation Propulsion Program (GAP). AGATE and GAP are providing industry partners with technologies leading to a Small Aircraft Transportation System (SATS) in the early 21st century. These investments support the national general aviation 'roadmap' goal to 'enable doorstep-to-destination travel at four times highway speeds to virtually all of the nation's suburban, rural and remote communities.' Image from AGATE 'business jet' video animation.

  19. Medicine as a business.

    PubMed

    Matthews, Merrill

    2004-09-01

    There is a growing debate over whether medicine should function like a business, guided, as businesses are, by concerns such as profits and customer satisfaction. Of course, for-profit businesses already permeate medicine, and those businesses are not confused about their priorities: providing high quality goods and services people want, at affordable prices. These companies know that they must do well in order to continue doing good. Critics of the business model argue that the profit motive makes health care too expensive and that only by nationalizing the health care system can doctors provide high quality care at an affordable cost to society. However, a survey of journals and newspaper articles about the Canadian health care system, often cited as an anti-business model for U.S. reform, reveals that quality has suffered significantly under that system. Patients wait in long lines for health care, and sometimes cannot get help at all. This paper argues that incentives in the U.S. health care system are complicated, and that health care needs to work more like a business--not less. Doctors don't know whom they are serving--patients, insurers, employers or the government--because it is usually someone other than the patient who it paying the bill. The way to get the incentives structured properly is to allow patients to control more of their health care dollars--perhaps through a system of Medical Savings Accounts. Following the business model is the only way to ensure that medicine provides high quality services at affordable prices--just like every other sector of the economy.

  20. Bringing science to business

    NASA Astrophysics Data System (ADS)

    Lemetti, Paul

    2005-06-01

    Bringing science to business seems rather straight forward. Technology is constantly moving forward and new inventions are being brought into the market place. Science parks and technology parks have sprung out all around the globe competing against each other and trying to keep their own doors open by bringing in new business, thereby creating much needed income to keep their operations moving forward. However, only a small handful ofthese centers around the world can truly be considered successful. It is the relationship between the scientists, start-up business, local universities, local government, and invited bigger business that allows the parks to succeed. The individual scientist wishing to enter into business or just hoping to get his invention into the pool of potential ideas; which might end up in the hands of an entrepreneur or an established company, is not always that simple. Universal success principles must be embraced to ensure success. One must believe in oneself and to strive for excellence. One must be able to see the other persons viewpoint and adapt and change his behavior in order to succeed. One must learn to create trust as well as learn to trust. Furthermore, one must learn to focus on the why of the process and not on the how. A market must be identified and benefits of local area must be sold to potential investor or business partners. A local success has in part to do with local cooperation.

  1. Evaluation of Psychotherapeutic Interpretations

    PubMed Central

    POGGE, DAVID L.; DOUGHER, MICHAEL J.

    1992-01-01

    If much psychotherapy literature goes unread and unused by therapists, one reason may be the apparent irrelevance of theory-derived hypotheses to actual practice. Methods that uncover tacit knowledge that practicing therapists already possess can provide the empirical basis for more relevant theories and the testing of more meaningful hypotheses. This study demonstrates application of the phenomenological method to the question of evaluating psychotherapy. To discover how experienced psychotherapists evaluate interpretations made in actual psychotherapy sessions, therapists were asked to evaluate such interpretations from videotapes; analysis of responses yielded a set of 10 dimensions of evaluation. Such methods offer both practical utility and a source of theoretical growth anchored in the real world of the practicing therapist. PMID:22700101

  2. 76 FR 32231 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... Employment and Training Administration International Business Machines (IBM), Sales and Distribution Business... Business Machines (IBM), Sales and Distribution Business Unit, Global Sales Solution Department, off-site... and location is International Business Machines (IBM), Sales and Distribution Business Unit,...

  3. Tips for Mental Health Interpretation

    ERIC Educational Resources Information Center

    Whitsett, Margaret

    2008-01-01

    This paper offers tips for working with interpreters in mental health settings. These tips include: (1) Using trained interpreters, not bilingual staff or community members; (2) Explaining "interpreting procedures" to the providers and clients; (3) Addressing the stigma associated with mental health that may influence interpreters; (4) Defining…

  4. Information Systems and Business Communication.

    ERIC Educational Resources Information Center

    Beswick, Raymond W., Ed.; Williams, Alfred B., Ed.

    Intended to provide orientation about the integration of business communication, business systems, and the researching and teaching of business communication, this books offers articles on a variety of topics concerning business communication. Titles of the articles and their authors are as follows: (1) "Office Technology: Voice Store-and-Forward"…

  5. Standardized Curriculum for Business Technology.

    ERIC Educational Resources Information Center

    Mississippi State Dept. of Education, Jackson. Bureau of Vocational, Technical, and Adult Education.

    Standardized curricula are provided for five courses for the secondary business technology programs in Mississippi: intensive business training; information processing; business computer applications; and computer programing technology (CPT) I and II. The 20 units of intensive business training include the following: keyboarding; operation of…

  6. Small Business Management. Teacher Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This instructor's guide, which is designed to assist teachers in providing instruction and technical support to small business owners and managers, contains 17 competency-based units of instruction on the following areas that both small business instructors and small business owners have deemed critical to the success of any business:…

  7. Interpreting uncertainty terms.

    PubMed

    Holtgraves, Thomas

    2014-08-01

    Uncertainty terms (e.g., some, possible, good, etc.) are words that do not have a fixed referent and hence are relatively ambiguous. A model is proposed that specifies how, from the hearer's perspective, recognition of facework as a potential motive for the use of an uncertainty term results in a calibration of the intended meaning of that term. Four experiments are reported that examine the impact of face threat, and the variables that affect it (e.g., power), on the manner in which a variety of uncertainty terms (probability terms, quantifiers, frequency terms, etc.) are interpreted. Overall, the results demonstrate that increased face threat in a situation will result in a more negative interpretation of an utterance containing an uncertainty term. That the interpretation of so many different types of uncertainty terms is affected in the same way suggests the operation of a fundamental principle of language use, one with important implications for the communication of risk, subjective experience, and so on.

  8. Interpretation and creationism.

    PubMed

    Ahumada, J L

    1994-08-01

    This paper is an attempt to raise questions about certain underlying and implicit assumptions in some hermeneutic and narrative approaches to psychoanalysis. Starting from the view that Freud saw interpretation in the clinical setting as an attempt to unveil the analysand's psychic reality, it is argued that he envisaged that psychoanalysis aims to interpret what is real in the analysand's inner world--an empirical line of thought underpinned by the idea of analytic neutrality and an emphasis on the analysand's capacity to judge reality. By contrast, the tendency within the hermeneutic-narrative tradition is to demote psychic reality in favour of an emphasis on the analyst's capacity to interpret in order to help his analysand construct meaning. This approach may be said to put the analyst's words in the place of those of the Creator; in other words, it amounts to a 'verbal creationism', which the author argues is rooted in the idealistic philosophy of Hegel, Vico and Descartes and, further back, can be traced to the Book of Genesis--a conclusion causing the author to express some reservations.

  9. Navigating the Interface between Design Education and Fashion Business Start-up

    ERIC Educational Resources Information Center

    Mills, Colleen E.

    2012-01-01

    Purpose: The purpose of this paper is to address the interface between design education and business start-up in the designer fashion industry (DFI) and provide a new framework for reflecting on ways to improve design education and graduates' business start-up preparedness. Design/methodology/approach: This interpretive study employed…

  10. Catholic Business Schools and the Crisis of the Academic Industry

    ERIC Educational Resources Information Center

    Hoevel, Carlos

    2012-01-01

    According to many analysts, after the dot-com, housing and financial bubbles, the next bubble to burst may be that of higher education and especially business education schools. Given this possible scenario, there are two ways one might interpret the current crisis in education, accompanied by two proposals for addressing the problems. According…

  11. Analysis of Farm Records. Teacher Edition. Farm Business Management Series.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This curriculum guide for the Oklahoma Farm Business Management Program contains three instructional units that teach students how to interpret farm records to get optimum use of facilities and maximize profits. Each unit of instruction includes some or all of these components: performance objectives, suggested activities for the instructor,…

  12. United States History in the Secondary Schools. Business.

    ERIC Educational Resources Information Center

    Point Pleasant Beach Board of Education, NJ.

    This is one unit of the series described in SO 000 378. One of the most important developments in the recent interpretations of American economic history has been the emphasis placed on business. The specific objectives of this unit are enumerated: 1) to realize that all resources are limited and the utilization of these resources is determined by…

  13. Effects of feeding frequency on apparent energy and nutrient digestibility/availability of channel catfish, Ictalurus punctatus, reared at optimal and suboptimal temperatures

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study examined the effects of feeding frequency (daily versus every other day [EOD]) on nutrient digestibility/availability of channel catfish, Ictalurus punctatus, reared at optimal (30 C) and suboptimal (24 C) temperatures. A 28% protein practical diet was used as the test diet, and chromic o...

  14. Comparative assessment of 5' A/T-rich overhang sequences with optimal and sub-optimal primers to increase PCR yields and sensitivity.

    PubMed

    Arif, M; Ochoa-Corona, F M

    2013-09-01

    Efficient PCR amplifications require precisely designed and optimized oligonucleotide primers, components, and cycling conditions. Despite recent software development and reaction improvement, primer design can still be enhanced. The aims of this research are to understand (1) the effect on PCR efficiency and DNA yields of primer thermodynamics parameters, and (2) the incorporation of 5' A/T-rich overhanging sequences (flaps) during primer design. Two primer sets, one optimal (ΔG = 0) and one sub-optimal (ΔG = 0.9), were designed using web interface software Primer3, BLASTn, and mFold to target a movement protein gene of Tobacco mosaic virus. The optimal primer set amplifies a product of 195 bp and supports higher PCR sensitivity and yields compared to the sub-optimal primer set, which amplifies a product of 192 bp. Greater fluorescence was obtained using optimal primers compared to that with sub-optimal primers. Primers designed with sub-optimal thermodynamics can be substantially improved by adding 5' flaps. Results indicate that even if the performance of some primers can be improved substantially by 5' flap addition, not all primers will be similarly improved. Optimal 5' flap sequences are dependent on the primer sequences, and alter the primer's T m value. The manipulation of this feature may enhance primer's efficiency to increase the PCR sensitivity and DNA yield.

  15. Long-term excessive magnesium supplementation is deleterious whereas suboptimal supply is beneficial for bones in rats.

    PubMed

    Riond, J L; Hartmann, P; Steiner, P; Ursprung, R; Wanner, M; Forrer, R; Spichiger, U E; Thomsen, J S; Mosekilde, L

    2000-12-01

    The long-term effects of a suboptimal magnesium supply inducing a marginal or moderate deficiency or of an excessive magnesium supplementation corresponding to a basal diet with a high pharmacological intake were investigated in 36 growing Sprague-Dawley female rats. The rats were randomly divided in three groups and received a purified diet with 7 g calcium, 5 g phosphorus and either 0.2, 0.5 or 2 g magnesium per kg diet for 7 months. At the end of the trial, plasma and erythrocyte total magnesium concentrations were significantly lower in the magnesium-deficient group than in the respective control group. Serum concentrations of 1,25-dihydroxyvitamin D, PTH and IGF-I and the length of the right humeri were not affected by the dietary treatment. The volumes corrected for body weight, the medio-lateral diameters and the ratios dry weight/length of the right humeri, and the dry weight corrected for body weight of the left tibiae and of the right humeri were significantly smaller in the magnesium-supplemented group than in the two other groups. The magnesium contents of the left tibiae and of the first lumbar vertebrae were significantly lower in the magnesium-deficient group than in the two other groups. In the right femora, dual energy X-ray absorptiometry revealed significantly smaller areas in the proximal part and significantly smaller mineral contents in the second proximal quarter in the magnesium-supplemented group compared with the two other groups. Peripheral quantitative computer tomography of the right humeri revealed in the cortex significantly larger values for the relative area, mineral content, mineral density and thickness in the magnesium-deficient group compared with the control group. The maximum point of the load-deformation curve was significantly reduced in the fifth lumbar vertebrae and in the proximal femoral metaphyses of the magnesium-supplemented group. These results indicate that the long-term suboptimal magnesium supply improved some of

  16. Sub-optimal control of unsteady boundary layer separation and optimal control of Saltzman-Lorenz model

    NASA Astrophysics Data System (ADS)

    Sardesai, Chetan R.

    The primary objective of this research is to explore the application of optimal control theory in nonlinear, unsteady, fluid dynamical settings. Two problems are considered: (1) control of unsteady boundary-layer separation, and (2) control of the Saltzman-Lorenz model. The unsteady boundary-layer equations are nonlinear partial differential equations that govern the eruptive events that arise when an adverse pressure gradient acts on a boundary layer at high Reynolds numbers. The Saltzman-Lorenz model consists of a coupled set of three nonlinear ordinary differential equations that govern the time-dependent coefficients in truncated Fourier expansions of Rayleigh-Renard convection and exhibit deterministic chaos. Variational methods are used to derive the nonlinear optimal control formulations based on cost functionals that define the control objective through a performance measure and a penalty function that penalizes the cost of control. The resulting formulation consists of the nonlinear state equations, which must be integrated forward in time, and the nonlinear control (adjoint) equations, which are integrated backward in time. Such coupled forward-backward time integrations are computationally demanding; therefore, the full optimal control problem for the Saltzman-Lorenz model is carried out, while the more complex unsteady boundary-layer case is solved using a sub-optimal approach. The latter is a quasi-steady technique in which the unsteady boundary-layer equations are integrated forward in time, and the steady control equation is solved at each time step. Both sub-optimal control of the unsteady boundary-layer equations and optimal control of the Saltzman-Lorenz model are found to be successful in meeting the control objectives for each problem. In the case of boundary-layer separation, the control results indicate that it is necessary to eliminate the recirculation region that is a precursor to the unsteady boundary-layer eruptions. In the case of the

  17. Methionine Sulfoxide Reductase from the Hyperthermophilic Archaeon Thermococcus kodakaraensis, an Enzyme Designed To Function at Suboptimal Growth Temperatures▿

    PubMed Central

    Fukushima, Eiji; Shinka, Yasuhiro; Fukui, Toshiaki; Atomi, Haruyuki; Imanaka, Tadayuki

    2007-01-01

    Methionine sulfoxide reductase (Msr) catalyzes the thioredoxin-dependent reduction and repair of methionine sulfoxide (MetO). Although Msr genes are not present in most hyperthermophile genomes, an Msr homolog encoding an MsrA-MsrB fusion protein (MsrABTk) was present on the genome of the hyperthermophilic archaeon Thermococcus kodakaraensis. Recombinant proteins corresponding to MsrABTk and the individual domains (MsrATk and MsrBTk) were produced, purified, and biochemically examined. MsrATk and MsrBTk displayed strict substrate selectivity for Met-S-O and Met-R-O, respectively. MsrABTk, and in particular the MsrB domain of this protein, displayed an intriguing behavior for an enzyme from a hyperthermophile. While MsrABTk was relatively stable at temperatures up to 80°C (with a half-life of ∼30 min at 80°C), a 75% decrease in activity was observed after 2.5 min at 85°C, the optimal growth temperature of this archaeon. Moreover, maximal levels of MsrB activity of MsrABTk were observed at the strikingly low temperature of 30°C, which also was observed for MsrBTk. Consistent with the low-temperature-specific biochemical properties of MsrABTk, the presence of the protein was greater in T. kodakaraensis cells grown at suboptimal temperatures (60 to 70°C) and could not be detected at 80 to 90°C. We found that the amount of intracellular MsrABTk protein increased with exposure to higher dissolved oxygen levels, but only at suboptimal growth temperatures. While measuring background rates of the Msr enzyme reactions, we observed significant levels of MetO reduction at high temperatures without enzyme. The occurrence of nonenzymatic MetO reduction at high temperatures may explain the specific absence of Msr homologs in most hyperthermophiles. Together with the fact that the presence of Msr in T. kodakaraensis is exceptional among the hyperthermophiles, the enzyme may represent a novel strategy for this organism to deal with low-temperature environments in which the

  18. Interpreting Transistor Noise

    NASA Astrophysics Data System (ADS)

    Pospieszalski, M. W.

    2010-10-01

    The simple noise models of field effect and bipolar transistors reviewed in this article are quite useful in engineering practice, as illustrated by measured and modeled results. The exact and approximate expressions for the noise parameters of FETs and bipolar transistors reveal certain common noise properties and some general noise properties of both devices. The usefulness of these expressions in interpreting the dependence of measured noise parameters on frequency, bias, and temperature and, consequently, in checking of consistency of measured data has been demonstrated.

  19. Interpretation of the geoid

    NASA Technical Reports Server (NTRS)

    Runcorn, S. K.

    1985-01-01

    The superposition of the first satellite geoid determined by Iszak upon Ootilla's geoid was based on surface gravity determinations. Good agreement was observed except over the Pacific area of the globe. The poor agreement over the Pacific was interpreted as the result of inadequate observations there. Many geoids were determined from satellite observations, including Doppler measurements. It is found that the geoid is the result of density differences in the mantle maintained since the primeval Earth by its finite strength. Various models based on this assumption are developed.

  20. [The telephone interpreter. A good alternative to the traditional interpreter].

    PubMed

    Karlsen, W B; Haabeth, A L

    1998-01-20

    In the health care system, good communication is of vital importance for correct information, diagnosis and treatment. When the health care worker and the patient have no common language, an interpreter is needed. In a small population the patient and the interpreter will often be acquainted. In small, local communities few professional interpreters are available. These communities can be served by offering a telephone interpreter, thus providing foreign citizens with a better health service. The presence of an interpreter reduces the possibility of being anonymous. The patient may withhold important information, or give incorrect information. By using a telephone interpreter, neither the patient nor the interpreter needs to know who the other person is. We found this to be a very good alternative in most cases, and sometimes a better solution. A good, loud-speaking telephone was needed. The interpreters were not as satisfied as the doctors and patients. Further development of the service is therefore required.

  1. Root-Zone Warming Differently Benefits Mature and Newly Unfolded Leaves of Cucumis sativus L. Seedlings under Sub-Optimal Temperature Stress

    PubMed Central

    Miao, Yanxiu; Gao, Lihong

    2016-01-01

    Sub-optimal temperature extensively suppresses crop growth during cool-season greenhouse production. Root-zone (RZ) warming is considered an economical option to alleviate crop growth reduction. In this study we cultivated cucumber seedlings in nutrient solution under different air-RZ temperature treatments to investigate the effects of RZ warming on seedling growth- and photosynthesis-related parameters in leaves. The air-RZ temperature treatments included sub-optimal RZ temperature 13°C and sub-optimal air temperature 20/12°C (day/night) (S13), RZ warming at 19°C and sub-optimal air temperature (S19), and RZ warming at 19°C and optimal air temperature 26/18°C (day/night) (O19). In addition, for each air-RZ temperature treatment, half of the seedlings were also treated with 2% (m/m) polyethylene glycol (PEG) dissolved in nutrient solution to distinguish the effect of root-sourced water supply from RZ temperature. At the whole-plant level, S19 significantly increased the relative growth rate (RGR) by approximately 18% compared with S13, although the increase was less than in O19 (50%) due to delayed leaf emergence. S19 alleviated both diffusive and metabolic limitation of photosynthesis in mature leaves compared with S13, resulting in a photosynthetic rate similar to that in O19 leaves. In newly unfolded leaves, S19 significantly promoted leaf area expansion and alleviated stomatal limitation of photosynthesis compared with S13. PEG addition had a limited influence on RGR and leaf photosynthesis, but significantly suppressed new leaf expansion. Thus, our results indicate that under sub-optimal temperature conditions, RZ warming promotes cucumber seedling growth by differently benefiting mature and newly unfolded leaves. In addition, RZ warming enhanced root-sourced water supply, mainly promoting new leaf expansion, rather than photosynthesis. PMID:27152599

  2. Cost-Effectiveness of Extended-Release Methylphenidate in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder Sub-Optimally Treated with Immediate Release Methylphenidate

    PubMed Central

    van der Schans, Jurjen; Kotsopoulos, Nikos; Hoekstra, Pieter J.; Hak, Eelko; Postma, Maarten J.

    2015-01-01

    Background Attention-Deficit/Hyperactivity Disorder (ADHD) is a common psychiatric disorder in children and adolescents. Immediate-release methylphenidate (IR-MPH) is the medical treatment of first choice. The necessity to use several IR-MPH tablets per day and associated potential social stigma at school often leads to reduced compliance, sub-optimal treatment, and therefore economic loss. Replacement of IR-MPH with a single-dose extended release (ER-MPH) formulation may improve drug response and economic efficiency. Objective To evaluate the cost-effectiveness from a societal perspective of a switch from IR-MPH to ER-MPH in patients who are sub-optimally treated. Methods A daily Markov-cycle model covering a time-span of 10 years was developed including four different health states: (1) optimal response, (2) sub-optimal response, (3) discontinued treatment, and (4) natural remission. ER-MPH options included methylphenidate osmotic release oral system (MPH-OROS) and Equasym XL/Medikinet CR. Both direct costs and indirect costs were included in the analysis, and effects were expressed as quality-adjusted life years (QALYs). Univariate, multivariate as well as probabilistic sensitivity analysis were conducted and the main outcomes were incremental cost-effectiveness ratios. Results Switching sub-optimally treated patients from IR-MPH to MPH-OROS or Equasym XL/Medikinet CR led to per-patient cost-savings of €4200 and €5400, respectively, over a 10-year treatment span. Sensitivity analysis with plausible variations of input parameters resulted in cost-savings in the vast majority of estimations. Conclusions This study lends economic support to switching patients with ADHD with suboptimal response to short-acting IR-MPH to long-acting ER-MPH regimens. PMID:26024479

  3. An intentional interpretive perspective

    PubMed Central

    Neuman, Paul

    2004-01-01

    To the extent that the concept of intention has been addressed within behavior analysis, descriptions of intention have been general and have not specifically included important distinctions that differentiate a behavior-analytic approach from vernacular definitions of intention. A fundamental difference between a behavior-analytic approach and most other psychological approaches is that other approaches focus on the necessity of intentions to explain behavior, whereas a behavior-analytic approach is directed at understanding the interplay between behavior and environment. Behavior-analytic interpretations include the relations between the observer's behavior and the environment. From a behavior-analytic perspective, an analysis of the observer's interpretations of an individual's behavior is inherent in the subsequent attribution of intention. The present agenda is to provide a behavior-analytic account of attributing intention that identifies the establishing conditions for speaking of intention. Also addressed is the extent to which we speak of intentions when the observed individual's behavior is contingency shaped or under instructional control. PMID:22478417

  4. Physical interpretation of antigravity

    NASA Astrophysics Data System (ADS)

    Bars, Itzhak; James, Albin

    2016-02-01

    Geodesic incompleteness is a problem in both general relativity and string theory. The Weyl-invariant Standard Model coupled to general relativity (SM +GR ), and a similar treatment of string theory, are improved theories that are geodesically complete. A notable prediction of this approach is that there must be antigravity regions of spacetime connected to gravity regions through gravitational singularities such as those that occur in black holes and cosmological bang/crunch. Antigravity regions introduce apparent problems of ghosts that raise several questions of physical interpretation. It was shown that unitarity is not violated, but there may be an instability associated with negative kinetic energies in the antigravity regions. In this paper we show that the apparent problems can be resolved with the interpretation of the theory from the perspective of observers strictly in the gravity region. Such observers cannot experience the negative kinetic energy in antigravity directly, but can only detect in and out signals that interact with the antigravity region. This is no different from a spacetime black box for which the information about its interior is encoded in scattering amplitudes for in/out states at its exterior. Through examples we show that negative kinetic energy in antigravity presents no problems of principles but is an interesting topic for physical investigations of fundamental significance.

  5. AGATE animation - business theme

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Business jet 2 of 6. Advanced General Aviation Technology Experiment (AGATE). Few objects convey wealth and power like a private airplane, but one day you won't have to be rich or famous to fly one. NASA is working with industry and other government agencies to develop the technology and vision for business and personal travel of the future. It's a future in which travelers fly to their destinations in small, safe, affordable and easy-to-use jets out of 'smart airports.' Future small aircraft may cost about as much as a luxury automobile. They will use 25% less fuel than today's airplanes with fuel efficiencies rivaling automobiles, but at four times highway speeds. The goal is to put 'wings on America' and enable doorstep-to-destination travel at four times the speed of highways, making it possible to go where you want, when you want - faster than ever. Image from AGATE 'business jet' video animation.

  6. Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal.

    PubMed

    Lieben, Liesbet; Verlinden, Lieve; Masuyama, Ritsuko; Torrekens, Sophie; Moermans, Karen; Schoonjans, Luc; Carmeliet, Peter; Carmeliet, Geert

    2015-12-01

    The active form of vitamin D, 1,25(OH)2D, is a crucial regulator of calcium homeostasis, especially through stimulation of intestinal calcium transport. Lack of intestinal vitamin D receptor (VDR) signaling does however not result in hypocalcemia, because the increased 1,25(OH)2D levels stimulate calcium handling in extra-intestinal tissues. Systemic VDR deficiency, on the other hand, results in hypocalcemia because calcium handling is impaired not only in the intestine, but also in kidney and bone. It remains however unclear whether low intestinal VDR activity, as observed during aging, is sufficient for intestinal calcium transport and for mineral and bone homeostasis. To this end, we generated mice that expressed the Vdr exclusively in the gut, but at reduced levels. We found that ~15% of intestinal VDR expression greatly prevented the Vdr null phenotype in young-adult mice, including the severe hypocalcemia. Serum calcium levels were, however, in the low-normal range, which may be due to the suboptimal intestinal calcium absorption, renal calcium loss, insufficient increase in bone resorption and normal calcium incorporation in the bone matrix. In conclusion, our results indicate that low intestinal VDR levels improve intestinal calcium absorption compared to Vdr null mice, but also show that 1,25(OH)2D-mediated fine-tuning of renal calcium reabsorption and bone mineralization and resorption is required to maintain fully normal serum calcium levels.

  7. Suboptimal Plasma Long Chain n-3 Concentrations are Common among Adults in the United States, NHANES 2003–2004

    PubMed Central

    Murphy, Rachel A.; Yu, Elaine A.; Ciappio, Eric D.; Mehta, Saurabh; McBurney, Michael I.

    2015-01-01

    Population data on long-chain omega-3 polyunsaturated fatty acid (LCn-3 PUFA) status from biomarkers of dietary intake is lacking. The objectives were to describe plasma LCn-3 PUFA concentrations and compare them to concentrations associated with cardiovascular health and dietary recommendations for two servings of seafood/week. Fasting plasma fatty acids were measured among 1386 subjects ≥20 years from the National Health and Nutrition Examination Survey, 2003–2004. LCn-3 concentrations represent the sum of eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid relative to total fatty acids (expressed as a percentage). Mean LCn-3 PUFA concentration was 2.07% (95% CI 1.95–2.19). Overall, 80.6% of participants had LCn-3 below concentrations recommended for cardiovascular health. Hispanic participants were the most likely to have LCn-3 PUFA below recommended levels. Nearly all participants (95.7%) had LCn-3 below concentrations associated with cardiovascular protection. Older participants (≥60 years) had higher LCn-3 PUFA concentrations than those aged 20–39 years but not aged 40–59 years. LCn-3 PUFA concentrations were lower for Hispanic participants relative to non-Hispanic black participants. Suboptimal LCn-3 concentrations are common among U.S. adults. These findings highlight the need to increase LCn-3 intake among Americans. PMID:26690213

  8. Effects of mannan oligosaccharide and virginiamycin on the cecal microbial community and intestinal morphology of chickens raised under suboptimal conditions.

    PubMed

    Pourabedin, Mohsen; Xu, Zhengxin; Baurhoo, Bushansingh; Chevaux, Eric; Zhao, Xin

    2014-05-01

    There is an increasing movement against use of antibiotic growth promoters in animal feed. Prebiotic supplementation is a potential alternative to enhance the host's natural defense through modulation of gut microbiota. In the present study, the effect of mannan oligosaccharide (MOS) and virginiamycin (VIRG) on cecal microbial ecology and intestinal morphology of broiler chickens raised under suboptimal conditions was evaluated. MOS and VIRG induced different bacterial community structures, as revealed by denaturing gradient gel electrophoresis of 16S rDNA. The antibiotic treatment reduced cecal microbial diversity while the community equitability increased. A higher bacterial diversity was observed in the cecum of MOS-supplemented birds. Quantitative polymerase chain reaction results indicated that MOS changed the cecal microbiota in favor of the Firmicutes population but not the Bacteroidetes population. No difference was observed in total bacterial counts among treatments. MOS promoted the growth of Lactobacillus spp. and Bifidobacterium spp. in the cecum and increased villus height and goblet cell numbers in the ileum and jejunum. These results provide a deeper insight into the microbial ecological changes after supplementation of MOS prebiotic in poultry diets.

  9. Determinants of suboptimal complementary feeding practices among children aged 6-23 months in four anglophone West African countries.

    PubMed

    Issaka, Abukari I; Agho, Kingsley E; Page, Andrew N; Burns, Penelope L; Stevens, Garry J; Dibley, Michael J

    2015-10-01

    Suboptimal complementary feeding practices have a detrimental impact on a child's growth, health and development in the first two years of life. They lead to child malnutrition, which contributes to the high prevalence of stunting (38%) and underweight (28%) reported for children <5 years of age in Sub-Saharan Africa. This study analysed complementary feeding practices in four anglophone West African countries (Ghana, Liberia, Nigeria and Sierra Leone) using the most recent Demographic and Health Surveys. The study covered 12 623 children aged 6-23 months from four anglophone West African countries (Ghana: 822 children: Liberia: 1458 children, Nigeria: 8786 children and Sierra Leone: 1557 children). Four complementary feeding indicators were examined against a set of individual-, household- and community-level factors, using multiple regression analysis. Multivariate analyses found that lack of post-natal contacts with health workers, maternal illiteracy and geographical region were common determinants of delayed introduction of solid, semi-solid or soft foods across all four countries. Predictors for minimum dietary diversity, minimum meal frequency and minimum acceptable diet included children aged 6-11 months, administrative/geographical region, poorer household income and limited access to media. The authors recommend that the four anglophone West African countries studied should prioritise efforts to improve complementary feeding practices in order to reduce child morbidity and mortality. Interventional studies on complementary feeding should target those from poor and illiterate households.

  10. I just want my research credit: frequency of suboptimal effort in a non-clinical healthy undergraduate sample.

    PubMed

    DeRight, Jonathan; Jorgensen, Randall S

    2015-01-01

    Although performance validity testing is becoming fairly routine in clinical settings, research protocols involving neuropsychological tests infrequently include assessments of performance validity. The current study utilized an embedded measure of effort over two administrations of CNS Vital Signs to determine the frequency of poor effort in non-clinical healthy undergraduate students participating in a research study for course credit. Results indicate that more than 1 in 10 college students participating in a cognitive test battery for research showed test scores consistent with inadequate effort, which was associated with poor performance on testing across many domains. This conclusion was supported by poor performance on many other subtests. Healthy college students with suboptimal effort (n = 11) had an overall score in the 15th percentile on average compared to the 48th percentile in the rest of the students (n = 66). Those who failed validity indicators on the baseline administration were more likely to fail validity indicators on the repeat administration. Those who were tested in the morning were also more likely to fail validity indicators. The current study provides evidence for the potential limitations of conducting research using neuropsychological tests with healthy college student volunteers in the absence of performance validity testing. Revised college-level cutoffs are proposed.

  11. [Effects of sodium naphthalene acetate on growth and physiological characteristics of tomato seedlings under suboptimal temperature and light condition].

    PubMed

    Guo, Yun-na; Li, Yan-su; He, Chao-xing; Yu, Xian-chang

    2015-10-01

    Taking tomato 'Zhongza 105' as test material, the influences of sodium naphthalene acetate (SNA) on growth and physiological characteristics of tomato seedlings under suboptimal temperature and light condition were investigated. The results showed that the dry mass, vigorous seedling index, root activity, total nitrogen content, net photosynthesis rate (Pn) of tomato seedlings were significantly decreased by suboptimum temperature and light treatment. In addition, the catalase activity and zeatin riboside (ZR) concentration were also reduced. However, the superoxide dismutase, peroxidase activity and the content of abscisic acid (ABA) were increased. Compared with treatment of the same volume distilled water on tomato seedlings under suboptimum temperature and light condition, the dry mass of whole plant and vigorous seedling index of tomato seedlings were significantly increased by 16.4% and 22.9%, as the total N contents in roots and leaves and Pn were also increased by 8.5%, 28.5%and 37.0%, respectively, with the treatment of root application of 10 mg . L-1 SNA. Besides protective enzyme activity and the root activity were improved, the indole acetic acid (IAA) and ZR concentration of tomato were raised, and ABA concentration was reduced. The results indicated that root application of certain concentration of SNA could promote the growth of tomato seedlings by increasing the tomato root activity, protective enzymes activity, Pn and regulating endogenous hormone concentration under suboptimum temperature and light condition.

  12. Optimal symmetric networks in terms of minimizing average shortest path length and their sub-optimal growth model

    NASA Astrophysics Data System (ADS)

    Xuan, Qi; Li, Yanjun; Wu, Tie-Jun

    2009-04-01

    Homogeneous entangled networks characterized by small world, large girths, and no community structure have attracted much attention due to some of their favorable performances. However, the optimization algorithm proposed by Donetti et al. is very time-consuming and will lose its efficiency when the size of the target network becomes large. In this paper, an alternative optimization algorithm is provided to get optimal symmetric networks by minimizing the average shortest path length. It is shown that the synchronizability of a symmetric network is enhanced when the average shortest path length of the network is shortened as the optimization proceeds, which suggests that the optimal symmetric networks in terms of minimizing average shortest path length will be very close to those entangled networks. In order to overcome the time-consuming obstacle of the optimization algorithms proposed by us and Donetti et al., a growth model is proposed to get large scale sub-optimal symmetric networks. Numerical simulations show that the symmetric networks derived by our growth model will have small-world property, and besides, these networks will have many other similar favorable performances as entangled networks, e.g., robustness against errors and attacks, very good load balancing ability, and strong synchronizability.

  13. Is the optimal intervention policy UC superior to the suboptimal policy MFPT over inferred probabilistic Boolean network models?

    PubMed

    Zan, X Z; Liu, W B; Hu, M X; Shen, L Z

    2016-12-19

    A salient problem in translational genomics is the use of gene regulatory networks to determine therapeutic intervention strategies. Theoretically, in a complete network, the optimal policy performs better than the suboptimal policy. However, this theory may not hold if we intervene in a system based on a control policy derived from imprecise inferred networks, especially in the small-sample scenario. In this paper, we compare the performance of the unconstrained (UC) policy with that of the mean-first-passage-time (MFPT) policy in terms of the quality of the determined control gene and the effectiveness of the policy. Our simulation results reveal that the quality of the control gene determined by the robust MFPT policy is better in the small-sample scenario, whereas the sensitive UC policy performs better in the large-sample scenario. Furthermore, given the same control gene, the MFPT policy is more efficient than the UC policy for the small-sample scenario. Owing to these two features, the MFPT policy performs better in the small-sample scenario and the UC policy performs better only in the large-sample scenario. Additionally, using a relatively complex model (gene number N is more than 1) is beneficial for the intervention process, especially for the sensitive UC policy.

  14. AGATE animation - business theme

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Business jet 4 of 6. Advanced General Aviation Technology Experiment (AGATE). The AGATE program is complimented by a NASA Lewis-led program to develop safe, smooth, quiet and affordable propulsion systems for future four-to-six-seat general aviation airplanes. The General Aviation Propulsion (GAP) program is developing diesel prop and jet engines to be flight demonstrated at the year 2000 EAA AirVenture Air Show & Convention in Oshkosh, Wisc. Commericially produced engines based on these demonstrator engines and their manufacturing technologies will soon follow. Image from AGATE 'business jet' video animation.

  15. A flexible business focus

    SciTech Connect

    Hennagir, T.

    1994-11-01

    The challenge of sourcing equipment to meet customer needs around the world remains a prerequisite for boiler and CFB manufacturers as they strive to maintain a strong business presence in key markets. Boiler vendors are learning to meet their targets based upon what the market is, not what they hope it will become. An elastic equipment supply strategy is bolstering new business activity for internationally active boiler and circulating fluidized bed combustion (CFB) vendors. Techniques such as flexible sourcing and expanded scope capability are helping suppliers gain market advantage in new global growth areas.

  16. Asynchronous interpretation of parallel microprograms

    SciTech Connect

    Bandman, O.L.

    1984-03-01

    In this article, the authors demonstrate how to pass from a given synchronous interpretation of a parallel microprogram to an equivalent asynchronous interpretation, and investigate the cost associated with the rejection of external synchronization in parallel microprogram structures.

  17. What Language Do Interpreters Speak?

    ERIC Educational Resources Information Center

    Parks, Gerald B.

    1982-01-01

    States that both the register and variety of an interpreter's speech are quite limited and analyzes the linguistic characteristics of "International English," the English used by interpreters at international conferences. (CFM)

  18. Generic interpreters and microprocessor verification

    NASA Technical Reports Server (NTRS)

    Windley, Phillip J.

    1990-01-01

    The following topics are covered in viewgraph form: (1) generic interpreters; (2) Viper microprocessors; (3) microprocessor verification; (4) determining correctness; (5) hierarchical decomposition; (6) interpreter theory; (7) AVM-1; (8) phase-level specification; and future work.

  19. Discussion of "interpretation and play".

    PubMed

    Pick, Irma Brenman

    2011-01-01

    This discussion addresses the conflict in technique between play versus interpretation. It further considers how the nature of the interpretation may be affected by a consideration of what is being projected into the analyst.

  20. Minority Business Enterprises and Woman Business Enterprises Grant Utilization

    EPA Pesticide Factsheets

    The policy goal of the MBE/WBE Programs is to assure that minority business enterprises and woman business enterprises are given the opportunity to participate in contract and procurement for supplies, construction, equipment & services under any EPA grant

  1. 3-D Seismic Interpretation

    NASA Astrophysics Data System (ADS)

    Moore, Gregory F.

    2009-05-01

    This volume is a brief introduction aimed at those who wish to gain a basic and relatively quick understanding of the interpretation of three-dimensional (3-D) seismic reflection data. The book is well written, clearly illustrated, and easy to follow. Enough elementary mathematics are presented for a basic understanding of seismic methods, but more complex mathematical derivations are avoided. References are listed for readers interested in more advanced explanations. After a brief introduction, the book logically begins with a succinct chapter on modern 3-D seismic data acquisition and processing. Standard 3-D acquisition methods are presented, and an appendix expands on more recent acquisition techniques, such as multiple-azimuth and wide-azimuth acquisition. Although this chapter covers the basics of standard time processing quite well, there is only a single sentence about prestack depth imaging, and anisotropic processing is not mentioned at all, even though both techniques are now becoming standard.

  2. The Interhospital Interpreter Project.

    PubMed

    Wlodarczyk, K

    1998-05-01

    My family immigrated to Canada when I was a child. Soon after we arrived, I became ill with acute appendicitis. For days, I lay in pain while my parents searched desperately for a physician. But in the small Ontario town where we had moved, there were no cultural interpreters. My parents faced not just a language barrier, but the barrier of a lack of knowledge of the health care system. They were unaware that an ill person could seek treatment in the emergency department of a general hospital. My parents finally found someone who could help, and I was treated just hours before my appendix would have ruptured. I will never forget those days of pain and fear.

  3. Interpretation of galaxy counts

    SciTech Connect

    Tinsely, B.M.

    1980-10-01

    New models are presented for the interpretation of recent counts of galaxies to 24th magnitude, and predictions are shown to 28th magnitude for future comparison with data from the Space Telescope. The results supersede earlier, more schematic models by the author. Tyson and Jarvis found in their counts a ''local'' density enhancement at 17th magnitude, on comparison with the earlier models; the excess is no longer significant when a more realistic mixture of galaxy colors is used. Bruzual and Kron's conclusion that Kron's counts show evidence for evolution at faint magnitudes is confirmed, and it is predicted that some 23d magnitude galaxies have redshifts greater than unity. These may include spheroidal systems, elliptical galaxies, and the bulges of early-type spirals and S0's, seen during their primeval rapid star formation.

  4. Interpreting bruises at necropsy

    PubMed Central

    Vanezis, P

    2001-01-01

    The accurate interpretation of bruising at necropsy is essential to understanding how a victim has been injured and assists the pathologist in a reliable reconstruction of the events leading to death. It is essential not only to assess the mechanism of production of a bruise, taking into account the type of impacting surface and the magnitude of force used, but also to estimate when the injury was caused. An account is given of the various methods used in the examination of bruises, particularly with respect to aging, as well as the factors that may affect their appearance. Differentiation from artefacts resulting from postmortem changes is also discussed in some detail. Key Words: bruising • necropsy • time of death • cause of death PMID:11328832

  5. A History of Oral Interpretation.

    ERIC Educational Resources Information Center

    Bahn, Eugene; Bahn, Margaret L.

    This historical account of the oral interpretation of literature establishes a chain of events comprehending 25 centuries of verbal tradition from the Homeric Age through 20th Century America. It deals in each era with the viewpoints and contributions of major historical figures to oral interpretation, as well as with oral interpretation's…

  6. Ohio Guidelines for Educational Interpreters.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Special Education.

    This document presents Ohio's state guidelines to assist school districts in providing appropriate educational interpreting services for students who have hearing impairments. A section on the primary role of the educational interpreter considers: necessary knowledge and skills, modes of communication, interpreting environments, testing…

  7. Business Planning Core Facilities

    PubMed Central

    Itzkowitz, G.N.

    2014-01-01

    Thoughtful business planning is pivotal to the success of any business/operational venture. When planned in a thoughtful and detailed manner there are very few operational or financial surprises for an institution or facility (service center) to contend with. At Stony Brook Medicine we include SWOT analysis and a detailed Market Analysis as part of the process. This is bolstered by an initiative to ensure institutional policies are met so that facilities remain in compliance throughout their lifecycle. As we operate 14 facilities we have had the opportunity to become creative in our approach to coordinate activities, virtualize services, integrate new software business-to-business partners, and finally coordinate plans for phased consolidation instead of outright termination of services when required. As the Associate Dean for Scientific Operations and Research Facilities, the shared research facilities (cores) of the Medical School are in my direct line of sight. We understand their value to the meeting our overall research mission. We have found that an active process of monitoring to predict trouble as much as possible is the best approach for facilities. Some case analysis of this type of interaction will be presented as well.

  8. Doing Business with China.

    ERIC Educational Resources Information Center

    Department of Commerce, Washington, DC. Industry and Trade Administration.

    This publication provides background and practical information for those interested in doing business with China. The United States officially recognized the People's Republic of China (PRC) on January 1, 1979. Chinese leaders view international trade as an important factor in transforming China into a modern industrial state as well as an…

  9. Business Development Corporation, Inc.

    SciTech Connect

    Jasek, S.

    1995-12-31

    Business Development Corporation, Inc., is a company specializing in opportunity seeking and business development activities in the {open_quotes}new{close_quotes} post communist Central and Eastern Europe, with particular emphasis on the Republics of Poland and Slovakia. The company currently focuses its expertise on strategic investing and business development between Central Europe and the United States of America. In Poland and Slovakia, the company specializes in developing large scale energy and environmental {open_quotes}infrastructure{close_quotes} development projects on the federal, state, and local level. In addition, the company assists large state owned industries in the transformation and privatization process. Business Development Corporation has assisted and continues to assist in projects of national importance. The staff of experts advise numerous large Polish and Slovak companies, most owned or in the process of privatization, on matters of restructuring, finance, capital structure, strategic parternships or investors, mergers, acquisitions and joint ventures with U.S. based firms. The company also assists and advises on a variety of environmental and energy matters in the public and private sector.

  10. Women and Business Management.

    ERIC Educational Resources Information Center

    Brown, Linda Keller

    1979-01-01

    Analyzes the current research on women as managers in business, commerce, and industry. Examines the areas of career choice and availability of women for managerial positions, stereotypes of managerial characteristics, the behavioral consequences of stereotypes, intrapsychic and structural barriers to advancement, and characteristics of the…

  11. Business Applications of WAP.

    ERIC Educational Resources Information Center

    van Steenderen, Margaret

    2002-01-01

    Explains the development of WAP (wireless application protocol), how it works, and what the major advantages and disadvantages are, especially when applied to the use of information. Topics include standardization; mobile communications; the effect of WAP on business tools, electronic commerce, and information services; consumers; corporate users;…

  12. Developing Rural Business Incubators.

    ERIC Educational Resources Information Center

    Weinberg, Mark L.; Burnier, DeLysa

    1991-01-01

    Offers background on rural entrepreneurship and incubation in the United States, with particular focus on rural incubators at community colleges and regional incubation systems. Explains how incubators, which provide shared services and business/management assistance for tenant companies, differ from other entrepreneurial development strategies.…

  13. Small Business Innovations

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Under an Army Small Business Innovation Research (SBIR) grant, Symbiotics, Inc. developed a software system that permits users to upgrade products from standalone applications so they can communicate in a distributed computing environment. Under a subsequent NASA SBIR grant, Symbiotics added additional tools to the SOCIAL product to enable NASA to coordinate conventional systems for planning Shuttle launch support operations. Using SOCIAL, data may be shared among applications in a computer network even when the applications are written in different programming languages. The product was introduced to the commercial market in 1993 and is used to monitor and control equipment for operation support and to integrate financial networks. The SBIR program was established to increase small business participation in federal R&D activities and to transfer government research to industry. InQuisiX is a reuse library providing high performance classification, cataloging, searching, browsing, retrieval and synthesis capabilities. These form the foundation for software reuse, producing higher quality software at lower cost and in less time. Software Productivity Solutions, Inc. developed the technology under Small Business Innovation Research (SBIR) projects funded by NASA and the Army and is marketing InQuisiX in conjunction with Science Applications International Corporation (SAIC). The SBIR program was established to increase small business participation in federal R&D activities and to transfer government research to industry.

  14. Dancing Partners: Schools & Businesses

    ERIC Educational Resources Information Center

    Johnston, Howard

    2009-01-01

    Business and education partnerships can be cornerstones of major school improvement efforts and meaningful corporate philanthropy. They also can be frustrating and wasteful if not planned and managed carefully. Partnerships, with their objectives, agreements, memorandums of understanding and budgets, may look like well-planned and carefully…

  15. Business Mathematics Curriculum.

    ERIC Educational Resources Information Center

    EASTCONN Regional Educational Services Center, North Windham, CT.

    This curriculum guide for teaching business mathematics in the Connecticut Vocational-Technical School System is based on the latest thinking of instructors in the field, suggestions from mathematics authorities, and current instructional approaches in education. The curriculum guide consists of six sections: (1) career relationships and…

  16. Today's Business Simulation Industry

    ERIC Educational Resources Information Center

    Summers, Gary J.

    2004-01-01

    New technologies are transforming the business simulation industry. The technologies come from research in computational fields of science, and they endow simulations with new capabilities and qualities. These capabilities and qualities include computerized behavioral simulations, online feedback and coaching, advanced interfaces, learning on…

  17. Business, Economics, Management Information.

    ERIC Educational Resources Information Center

    Kellogg, Edward Zip

    This annotated bibliography includes reference sources pertaining to business, economics, and management that are located in the libraries of the Portland and Gorham campuses of the University of Southern Maine. Specific reference sources are listed under the categories of: (1) indexes and abstracts; (2) dictionaries and encyclopedias, including…

  18. Hispanic Business Agenda.

    ERIC Educational Resources Information Center

    Coca-Cola USA, Atlanta, GA.

    This is a corporate policy statement of the Hispanic business agenda of Coca Cola USA, and the results of a community survey conducted to inform that agenda. The statement outlines several areas of company policy as they relate to Hispanic Americans. These areas include regional marketing, promotion, and community relations strategies, a…

  19. Open for Business

    ERIC Educational Resources Information Center

    Voyles, Bennett

    2007-01-01

    People know about the Sakai Project (open source course management system); they may even know about Kuali (open source financials). So, what is the next wave in open source software? This article discusses business intelligence (BI) systems. Though open source BI may still be only a rumor in most campus IT departments, some brave early adopters…

  20. Mental health: everyone's business.

    PubMed

    Dragon, Natalie

    2010-06-01

    Mental health is everyone's business the Australian College of Mental Health Nurses and the Wesley Mission affirmed last month. In the midst of a burgeoning demand for mental health services, the lack of funds allocated to mental health as part of a $7.3 billion health package in the federal budget does not add up.

  1. Business in the Community.

    ERIC Educational Resources Information Center

    O'Toole, Dennis M.; And Others

    1983-01-01

    Beginning with a theme article supplying teacher background material on the role of business in the community, this issue focuses on the profit motive, competition, and the use of resources. Four instructional units on this topic are included for young children. The pre-kindergarten unit, "Pancake Producers," has children observe workers cooking…

  2. Monitoring Business Processes

    NASA Astrophysics Data System (ADS)

    Bellandi, Valerio; Ceravolo, Paolo; Damiani, Ernesto; Frati, Fulvio

    In this chapter, we introduce the TEKNE Metrics Framework that performs services to monitor business processes. This framework was designed to support the prescription and explanation of these processes. TEKNE's most innovative contribution is managing data expressed in declarative form. To face this challenge, the TEKNE project implemented an infrastructure that relies on declarative Semantic Web technologies designed to be used in distributed systems.

  3. Business Education Curriculum.

    ERIC Educational Resources Information Center

    Alaska State Dept. of Education, Juneau. Div. of Adult and Vocational Education.

    This guide gives information on the skills and knowledge that students should acquire in a secondary-level business education program. Section 1 introduces the competency-based curriculum and discusses curriculum delivery systems, the role of the teacher in curriculum development, and options for program development. Goals, competencies, and…

  4. A Business Plan Outline.

    ERIC Educational Resources Information Center

    Kirchner, Charles, Ed.

    This document identifies the information that should be included in a business plan, and in what order, to make it an effective management tool and an effective tool to communicate a proposed or existing company's strengths and potential to potential financiers. Following an introduction, the document explains the following sections of a business…

  5. Getting down to Business

    ERIC Educational Resources Information Center

    Boser, Ulrich

    2007-01-01

    This article describes The Villages High School (VHS), a charter school where students are taught with real-world skills. At Villages High, a unique creation of local development company The Villages Of Lake-Sumter Inc., the curriculum is serious business. Under its charter agreement with the Sumter County school district, the school must provide…

  6. The Business of Education

    ERIC Educational Resources Information Center

    Barron, Michael

    2012-01-01

    This article is a response to John Silber's article, "Marketing Higher Education: The Survival Value of Integrity." Silber speaks to the very heart of the academy about its integrity and ethics, and does so in timeless fashion through the decades to the current era. In his introduction, he characterizes the "business of education" as inevitable…

  7. The Business of Learning

    ERIC Educational Resources Information Center

    Bers, Trudy; Gelfman, Arnold; Knapp, Jolene

    2008-01-01

    This article describes several community colleges that are taking a more business-like approach, trimming costs, improving efficiencies, and pursuing next-generation innovation--all while keeping the focus squarely where it should be: on learning. At Florida Keys Community College (FKCC), John Keho says his college is taking some strong--though…

  8. Doing business with NASA

    NASA Technical Reports Server (NTRS)

    1991-01-01

    A brochure that was designed to encourage contractors to do business with NASA is presented. The brochure is divided into six sections: (1) This is NASA; (2) The procurement process; (3) Marketing your capabilities; (4) Special assistance programs; (5) NASA field installations; and (6) Sources of additional help.

  9. Introducing a New Business Course: "Global Business and Sustainability"

    ERIC Educational Resources Information Center

    Marshall, R. Scott; Harry, Sean P.

    2005-01-01

    Purpose--To outline the themes, topics and material used in a new course, Global business and sustainability, for business educators interested in integrating this emerging paradigm into their courses. Design/methodology/approach--The structure, design and reference materials for the Global business and sustainability course are reviewed. Specific…

  10. Education Business Plan 2008-11: Ministry Business Plan

    ERIC Educational Resources Information Center

    Alberta Education, 2008

    2008-01-01

    The Ministry of Education has identified one core business that is an ongoing key responsibility. It is called "Core Business One: Lead and Support the Education System So That All Students Are Successful at Learning." The core business includes three goals with specific outcomes that describe the end results the Ministry wants to…

  11. Incorporating Business Communication in an Integrative Business Seminar.

    ERIC Educational Resources Information Center

    Luse, Donna W.

    1999-01-01

    Describes the Integrative Business Seminar in the College of Business Administration at Northeast Louisiana University in which the principal courses in business communication, management, marketing, and finance as well as a segment in problem solving, are taught as one 15-credit hour block in which subject areas are treated as an integrated…

  12. Business Office Clerical/Business Office Services. Teacher's Guide.

    ERIC Educational Resources Information Center

    Patton, Jan

    This curriculum guide for business office clerical/business office services provides instructional materials for Texas business course instructors. The following sections are included: (1) introduction; (2) keyboarding--skills, proofreading, and word processing; (3) filing--alphabetic, numeric, and electronic; (4) operating office…

  13. Business and Technology Concepts--Business Computations. Teacher's Guide.

    ERIC Educational Resources Information Center

    Illinois State Board of Education, Springfield. Dept. of Adult, Vocational and Technical Education.

    This Illinois State Board of Education teacher's guide on business computations is for students enrolled in the 9th or 10th grade. The course provides a foundation in arithmetic skills and their applications to common business problems for the senior high school vocational business courses. The curriculum guide includes teacher and student…

  14. Our Business World, Business Education: 7711.01.

    ERIC Educational Resources Information Center

    McAskill, Ava

    This Quinmester pamphlet presents an overview of the business world and the American free enterprise system, delving into the concept of profit, satisfaction of wants and needs through production and distribution of goods and services, and primary forms of business organization, the effects of business activity on economic growth, and the use of…

  15. Do Business Schools Value the Competencies that Businesses Value?

    ERIC Educational Resources Information Center

    Abraham, Steven Eric; Karns, Lanny A.

    2009-01-01

    The authors used survey research to determine the congruence among the competencies that businesses identify as being indicative of successful managers, the competencies that business schools identify as being indicative of successful graduates, and the competencies that are emphasized in business school curricula. The results show that although…

  16. The Great Divide between Business School Research and Business Practice

    ERIC Educational Resources Information Center

    Dostaler, Isabelle; Tomberlin, Thomas J.

    2013-01-01

    In their 2005 "Harvard Business Review" article, Bennis and O'Toole described business schools as being "on the wrong track" as a result of their focus on so-called scientific research. Some commentators argue that business schools have slowly lost their relevance since the end of the 1950s when they undertook a major overhaul in response to the…

  17. Taking Care of Business: Equipping Students to Become Business Journalists

    ERIC Educational Resources Information Center

    Hannis, Grant

    2016-01-01

    Informed, critical business journalism is vital to a well-functioning society. But students are typically reluctant to study business journalism, often finding the topic intimidating. This article outlines how the author has taught a business journalism course in New Zealand and the United States. The course uses a variety of methods to help the…

  18. Business as a Vocation: Catholic Social Teaching and Business Education

    ERIC Educational Resources Information Center

    Turkson, Peter K. A.

    2012-01-01

    Building on "Vocation of the Business Leader," the recently released document from the Pontifical Council for Justice and Peace, along with input from Catholic business and educational leaders from around the world, this essay examines five pillars on which a Catholic business school should build its mission: foundations; the purpose of…

  19. The English of Business Is the Business of English.

    ERIC Educational Resources Information Center

    Versluis, Edward B.

    Three arguments lead to the conclusion that the English of business is the business of English. First, reluctance to fully appreciate the English of Business stems in part from a serious misunderstanding about the development of written language in the Western tradition. While studying folktales and the origins of myths has made an awareness of…

  20. The Teaching of Business Ethics: An Imperative at Business Schools

    ERIC Educational Resources Information Center

    Crane, Frederick G.

    2004-01-01

    This study reports the findings of an investigation of MBAs and their views on the teaching of business ethics. The author found that tomorrow's business leaders believe that there are ethical standards that should be followed in business but that current ethical standards do not meet society's needs adequately. Moreover, although most respondents…

  1. Business School Internships: Legal Concerns.

    ERIC Educational Resources Information Center

    Swift, Cathy Owens; Kent, Russell

    1999-01-01

    Explores legal issues involved in business student internships for employers (compensation, workers' compensation, unemployment insurance, termination, equal-opportunities legislation, general liability) and for business schools (equal opportunities-legislation, general liability). (SK)

  2. Confidential Business Information under TSCA

    EPA Pesticide Factsheets

    This website informs businesses, policymakers, and the public about the confidential business information (CBI) provisions of § 14 of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act.

  3. Teaching Business Ethics through Literature.

    ERIC Educational Resources Information Center

    Shepard, Jon M.; Goldsby, Michael G.; Gerde, Virginia W.

    1997-01-01

    Business students need a vocabulary of ethics consistent with the ideology of capitalism. An approach using business-related classic literature (such as "Babbitt") is a way to develop vocabulary and explore ethical issues. (SK)

  4. Urban Farm Business Plan Handbook

    EPA Pesticide Factsheets

    The Urban Farm Business Plan Handbook (this document) provides guidance for developing a business plan for the startup and operation of an urban farm. It focuses on food and non-food related cultivated agriculture.

  5. What's a business for?

    PubMed

    Handy, Charles

    2002-12-01

    In the wake of the recent corporate scandals, it's time to reconsider the assumptions underlying American-style stock-market capitalism. That heady doctrine--in which the market is king, success is measured in terms of shareholder value, and profits are an end in themselves--enraptured America for a generation, spread to Britain during the 1980s, and recently began to gain acceptance in Continental Europe. But now, many wonder if the American model is corrupt. The American scandals are not just a matter of dubious personal ethics or of rogue companies fudging the odd billion. And the cure for the problems will not come solely from tougher regulations. We must also ask more fundamental questions: Whom and what is a business for? And are traditional ownership and governance structures suited to the knowledge economy? According to corporate law, a company's financiers are its owners, and employees are treated as property and recorded as costs. But while that may have been true in the early days of industry, it does not reflect today's reality. Now a company's assets are increasingly found in the employees who contribute their time and talents rather than in the stockholders who temporarily contribute their money. The language and measures of business must be reversed. In a knowledge economy, a good business is a community with a purpose, not a piece of property. If, like many European companies, a business considers itself a wealth-creating community consisting of members who have certain rights, those members will be more likely to treat one another as valued partners and take responsibility for telling the truth. Such a community can also help repair the image of business by insisting that its purpose is not just to make a profit but to make a profit in order to do something better.

  6. Small business innovation, research & development

    SciTech Connect

    Colvin, D.P.

    1995-12-31

    Historically, small businesses have been the innovation engine of the United States (US). The author provides statistical data that indicates that small business is really big business in the U.S. Small businesses are responsible for much of the applied research necessary for new product development. The author examines productivity, academic research and teaming as a cost-effective and time effective way to develop new products and technologies.

  7. The business of perioperative medicine.

    PubMed

    Rock, P; Lubarsky, D A

    2000-09-01

    Medical centers should insist that their top officials have a firm grasp of contemporary business principles, use that skill set, and run the medical business like any other. This business imperative does not exclude a conscious decision to measure success by the amount of articles published or charity care given rather than the amount of profits. Physician leaders should insist that while they care for patients, someone cares for the business.

  8. Role exchange in medical interpretation.

    PubMed

    White, Kari; Laws, M Barton

    2009-12-01

    Prior research has documented that medical interpreters engage in non-conduit roles during medical visits. However, agreement on the appropriateness of these roles and their impact on the medical encounter have not yet been achieved. The purpose of this study was to identify non-conduit behavior (role exchange), elucidate the various forms it takes among different types of interpreters, and assess its potential to affect clinical encounters. Using audiotapes from 13 pediatric outpatient visits, we found that "chance" and uncertified hospital interpreters engaged in role exchange by assuming the provider's role; the patient's role; and taking other non-interpretive roles such as socializing with mothers or acting in one's alternate professional role. These behaviors occurred frequently among both types of interpreters while the provider was actively engaged in conducting the medical visit. In most instances, the interpreter did not make his or her behavior transparent to either the provider or the mother. Implications for interpreter and provider training are discussed.

  9. The importance of inhaler devices: the choice of inhaler device may lead to suboptimal adherence in COPD patients

    PubMed Central

    Darbà, Josep; Ramírez, Gabriela; Sicras, Antoni; Francoli, Pablo; Torvinen, Saku; Sánchez-de la Rosa, Rainel

    2015-01-01

    Objective This study aims to identify factors associated with poor adherence to COPD treatment in patients receiving a fixed-dose combination (FDC) of inhaled corticosteroids and long-acting β2-agonist (ICS/LABA), focusing on the importance of inhaler devices. Methods We conducted a retrospective and multicenter study based on a review of medical registries between 2007 and 2012 of COPD patients (n=1,263) treated with ICS/LABA FDC, whose medical devices were either dry powder inhalers (DPIs) or pressurized metered-dose inhalers (pMDI). Medication adherence included persistence outcomes through 18 months and medication possession ratios. Data on exacerbations, comorbidities, demographic characteristics, and health care resource utilization were also included as confounders of adherence. Results The analyses revealed that COPD patients whose medication was delivered through a DPI were less likely to have medication adherence compared to patients with pMDI, after adjusting for confounding factors, especially active ingredients. Younger groups of patients were less likely to be adherent compared to the oldest group. Smoker men were less likely to be adherent compared to women and non-smokers. Comorbidities decreased the probability of treatment adherence. Those patients that visited their doctor once a month were more likely to adhere to their medication regimen; however, suboptimal adherence was more likely to occur among those patients who visited more than three times per month their doctor. We also found that worsening of COPD is negatively associated with adherence. Conclusion According to this study, inhaler devices influence patients’ adherence to long-term COPD medication. We also found that DPIs delivering ICS/LABA FDC had a negative impact on adherence. Patients’ clinic and socioeconomic characteristics were associated with adherence. PMID:26604733

  10. Root cortical aerenchyma enhances the growth of maize on soils with suboptimal availability of nitrogen, phosphorus, and potassium.

    PubMed

    Postma, Johannes Auke; Lynch, Jonathan Paul

    2011-07-01

    Root cortical aerenchyma (RCA) is induced by hypoxia, drought, and several nutrient deficiencies. Previous research showed that RCA formation reduces the respiration and nutrient content of root tissue. We used SimRoot, a functional-structural model, to provide quantitative support for the hypothesis that RCA formation is a useful adaptation to suboptimal availability of phosphorus, nitrogen, and potassium by reducing the metabolic costs of soil exploration in maize (Zea mays). RCA increased the growth of simulated 40-d-old maize plants up to 55%, 54%, or 72% on low nitrogen, phosphorus, or potassium soil, respectively, and reduced critical fertility levels by 13%, 12%, or 7%, respectively. The greater utility of RCA on low-potassium soils is associated with the fact that root growth in potassium-deficient plants was more carbon limited than in phosphorus- and nitrogen-deficient plants. In contrast to potassium-deficient plants, phosphorus- and nitrogen-deficient plants allocate more carbon to the root system as the deficiency develops. The utility of RCA also depended on other root phenes and environmental factors. On low-phosphorus soils (7.5 μM), the utility of RCA was 2.9 times greater in plants with increased lateral branching density than in plants with normal branching. On low-nitrate soils, the utility of RCA formation was 56% greater in coarser soils with high nitrate leaching. Large genetic variation in RCA formation and the utility of RCA for a range of stresses position RCA as an interesting crop-breeding target for enhanced soil resource acquisition.

  11. Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease

    PubMed Central

    Vilar-Pereira, Glaucia; Resende Pereira, Isabela; de Souza Ruivo, Leonardo Alexandre; Cruz Moreira, Otacilio; da Silva, Andrea Alice; Britto, Constança

    2016-01-01

    Chronic chagasic cardiomyopathy (CCC) progresses with parasite persistence, fibrosis, and electrical alterations associated with an unbalanced immune response such as high plasma levels of tumor necrosis factor (TNF) and nitric oxide (NO). Presently, the available treatments only mitigate the symptoms of CCC. To improve CCC prognosis, we interfered with the parasite load and unbalanced immune response using the trypanocidal drug benznidazole (Bz) and the immunoregulator pentoxifylline (PTX). C57BL/6 mice chronically infected with the Colombian strain of Trypanosoma cruzi and with signs of CCC were treated for 30 days with a suboptimal dose of Bz (25 mg/kg of body weight), PTX (20 mg/kg), or their combination (Bz plus PTX) and analyzed for electrocardiographic, histopathological, and immunological changes. Bz (76%) and Bz-plus-PTX (79%) therapies decreased parasite loads. Although the three therapies reduced myocarditis and fibrosis and ameliorated electrical alterations, only Bz plus PTX restored normal heart rate-corrected QT (QTc) intervals. Bz-plus-PTX-treated mice presented complementary effects of Bz and PTX, which reduced TNF expression (37%) in heart tissue and restored normal TNF receptor 1 expression on CD8+ T cells, respectively. Bz (85%) and PTX (70%) therapies reduced the expression of inducible nitric oxide synthase (iNOS/NOS2) in heart tissue, but only Bz (58%) reduced NO levels in serum. These effects were more pronounced after Bz-plus-PTX therapy. Moreover, 30 to 50 days after treatment cessation, reductions of the prolonged QTc and QRS intervals were sustained in Bz-plus-PTX-treated mice. Our findings support the importance of interfering with the etiological agent and immunological abnormalities to improve CCC prognosis, opening an opportunity for a better quality of life for Chagas' disease (CD) patients. PMID:27161638

  12. Effects of TCMC on Transformation of Good Health Status to Suboptimal Health Status: A Nested Case-Control Study

    PubMed Central

    Wang, Tian; Chen, Jieyu; Sun, Xiaomin; Xiang, Lei; Zhou, Lin; Li, Fei; Lin, Changsong; Jiang, Pingping; Wu, Shengwei; Xiao, Ya; Cheng, Jingru; Luo, Ren; Liu, Yanyan; Zhao, Xiaoshan

    2015-01-01

    To explore the effects of traditional Chinese medicine constitution (TCMC) on transformation of good health status to suboptimal health status (SHS), we conducted a nested case-control study among college students in China. During the 18-month mean follow-up time, 543 cases of SHS (42.7%) occurred in 1273 healthy students. There was a significant (P = 0.000) and marked reduction in SHMS V1.0 total score in the case group at the 18-month follow-up (69.32 ± 5.45) compared with baseline (78.60 ± 4.70), but there was no significant change in the control group. Conditional logistic regression analysis showed that respondents reporting Yin-deficiency and Qi-deficiency were, respectively, 2.247 and 2.198 times more likely to develop SHS, while tendency to Yin-deficiency and tendency to Damp-heat were, respectively, 1.642 and 1.506 times more likely to develop SHS. However, the Balanced Constitution was a significant protective factor (OR 0.649; P < 0.05). Altogether, these findings demonstrate that Yin-deficiency, Qi-deficiency, tendency to Yin-deficiency, and tendency to Damp-heat appeared to induce a change in health status to SHS, while the Balanced Constitution seemed to restrain this change. We conclude that regulating the unbalanced TCMC (such as Yin-deficiency and Qi-deficiency) may prevent a healthy status developing into SHS or lead to the regression of SHS. PMID:26346320

  13. LFA-1-dependent Ca2+ entry following suboptimal T cell receptor triggering proceeds without mobilization of intracellular Ca2+.

    PubMed

    Kim, Kwangmi; Wang, Lin; Hwang, Inkyu

    2009-08-14

    A surge in cytosolic calcium ion concentration by entry of extracellular Ca2+ is a hallmark of T cell activation. According to store-operated Ca2+ entry mechanism, the Ca2+ entry is preceded by activation of phospholipase C-gamma1 (PLC-gamma1) and the consequent mobilization of intracellular Ca2+. Using membrane vesicles expressing the mouse class I major histocompatibility complex, i.e. Ld plus costimulatory ligands, i.e. B7-1 and intercellular adhesion molecule-1 along with 2C T cell receptor transgenic T cells, we investigated the roles of CD28 and LFA-1 (lymphocyte function-associated antigen-1) in the activation of PLC-gamma1 and Ca2+ signaling. Both CD28 and LFA-1 made significant and comparable contributions to the activation of PLC-gamma1 as gauged by the level of its phosphorylation at tyrosine 783. In contrast, their roles in Ca2+ signaling were quite distinct so that LFA-1/intercellular adhesion molecule-1 interaction exerted a determining role, whereas CD28/B7-1 interaction played only a minimal role. In particular, when the T cells were activated by suboptimal T cell receptor stimulation, LFA-1 played an indispensable role in the Ca2+ signaling. Further experiments using Ca2+-free medium demonstrated that the entry of extracellular Ca2+ was not always accompanied by mobilization of intracellular Ca2+. Thus, intracellular Ca2+ mobilization was hardly detected under the condition that LFA-1 played the indispensable role in the entry of extracellular Ca2+, while a distinct level of intracellular Ca2+ mobilization was readily detected under the condition that LFA-1 played only the supporting role. These results ensure the unique role of LFA-1 in T cell Ca2+ signaling and reveal that LFA-1-dependent Ca2+ entry proceeds via a mechanism separate from store-operated Ca2+ entry.

  14. TsPAP1 encodes a novel plant prolyl aminopeptidase whose expression is induced in response to suboptimal growth conditions

    SciTech Connect

    Szawlowska, Urszula; Grabowska, Agnieszka; Zdunek-Zastocka, Edyta; Bielawski, Wieslaw

    2012-03-02

    Highlights: Black-Right-Pointing-Pointer A cDNA encoding a novel plant prolyl aminopeptidase, TsPAP1, was obtained from triticale. Black-Right-Pointing-Pointer The cloned TsPAP1 cDNA is 1387 bp long and encodes a protein of 390 amino acids. Black-Right-Pointing-Pointer The deduced TsPAP1 protein revealed characteristics of the monomeric bacterial PAPs. Black-Right-Pointing-Pointer The TsPAP1 mRNA level increased under drought, salinity and in the presence of metal ions. -- Abstract: A triticale cDNA encoding a prolyl aminopeptidase (PAP) was obtained by RT-PCR and has been designated as TsPAP1. The cloned cDNA is 1387 bp long and encodes a protein of 390 amino acids with a calculated molecular mass of 43.9 kDa. The deduced TsPAP1 protein exhibits a considerable sequence identity with the biochemically characterized bacterial and fungal PAP proteins of small molecular masses ({approx}35 kDa). Moreover, the presence of conserved regions that are characteristic for bacterial monomeric PAP enzymes (the GGSWG motif, the localization of the catalytic triad residues and the segment involved in substrate binding) has also been noted. Primary structure analysis and phylogenetic analysis revealed that TsPAP1 encodes a novel plant PAP protein that is distinct from the multimeric proteins that have thus far been characterized in plants and whose counterparts have been recognized only in bacteria and fungi. A significant increase in the TsPAP1 transcript level in the shoots of triticale plants was observed under drought and saline conditions as well as in the presence of cadmium and aluminium ions in the nutrient medium. This paper is the first report describing changes in the transcript levels of any plant PAP in response to suboptimal growth conditions.

  15. CD4 responses in the setting or suboptimal virological responses to antiretroviral therapy: features, outcomes, and associated factors.

    PubMed

    Collazos, Julio; Asensi, Víctor; Cartón, José Antonio

    2009-07-01

    The factors associated with discordant viroimmunological responses following antiretroviral therapy are unclear. We studied 1380 patients who initiated a protease inhibitor (PI)-based antiretroviral regimen and who fulfilled the criteria for inclusion. Of them, 255 (18.5%) had CD4 increases > or =100 cells/microl after 1 year of therapy despite detectable viral load (immunological responders); they were compared with 669 patients (48.5%) who had CD4 increases <100 cells/microl regardless of their final viral load (immunological nonresponders). Immunological responders had higher rates of sexual acquisition of HIV (p = 0.03), lower rates of clinical progression (p = 0.02), higher probabilities of being naive to antiretroviral therapy (p = 0.006) or to PI if antiretroviral experienced (p = 0.03), higher rates of receiving only nucleoside reverse transcriptase inhibitors in addition to the PI (p = 0.04), and lower baseline CD4 counts (p = 0.007) and higher viral loads (p = 0.009), as compared with nonresponders. Multivariate analysis revealed that sexual transmission of HIV (homosexual p = 0.004, heterosexual p = 0.03), no prior PI experience (p = 0.005), absence of clinical progression (p = 0.02), and lower baseline CD4 counts (p = 0.03) were independently associated with immunological response. However, these factors differed according to the patients' prior antiretroviral status, as higher baseline viral load was also associated with immunological response in antiretroviral-experienced patients (p = 0.02), whereas baseline CD4 count (p = 0.007) was the only predictive parameter in antiretroviral-naive patients. We conclude that immunological responses despite suboptimal viral suppression are common. Prior PI experience, HIV transmission category, baseline CD4 counts, and clinical progression were independently predictive of this condition, although the associated factors were different depending on the patient's prior antiretroviral history.

  16. Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease.

    PubMed

    Vilar-Pereira, Glaucia; Resende Pereira, Isabela; de Souza Ruivo, Leonardo Alexandre; Cruz Moreira, Otacilio; da Silva, Andrea Alice; Britto, Constança; Lannes-Vieira, Joseli

    2016-07-01

    Chronic chagasic cardiomyopathy (CCC) progresses with parasite persistence, fibrosis, and electrical alterations associated with an unbalanced immune response such as high plasma levels of tumor necrosis factor (TNF) and nitric oxide (NO). Presently, the available treatments only mitigate the symptoms of CCC. To improve CCC prognosis, we interfered with the parasite load and unbalanced immune response using the trypanocidal drug benznidazole (Bz) and the immunoregulator pentoxifylline (PTX). C57BL/6 mice chronically infected with the Colombian strain of Trypanosoma cruzi and with signs of CCC were treated for 30 days with a suboptimal dose of Bz (25 mg/kg of body weight), PTX (20 mg/kg), or their combination (Bz plus PTX) and analyzed for electrocardiographic, histopathological, and immunological changes. Bz (76%) and Bz-plus-PTX (79%) therapies decreased parasite loads. Although the three therapies reduced myocarditis and fibrosis and ameliorated electrical alterations, only Bz plus PTX restored normal heart rate-corrected QT (QTc) intervals. Bz-plus-PTX-treated mice presented complementary effects of Bz and PTX, which reduced TNF expression (37%) in heart tissue and restored normal TNF receptor 1 expression on CD8(+) T cells, respectively. Bz (85%) and PTX (70%) therapies reduced the expression of inducible nitric oxide synthase (iNOS/NOS2) in heart tissue, but only Bz (58%) reduced NO levels in serum. These effects were more pronounced after Bz-plus-PTX therapy. Moreover, 30 to 50 days after treatment cessation, reductions of the prolonged QTc and QRS intervals were sustained in Bz-plus-PTX-treated mice. Our findings support the importance of interfering with the etiological agent and immunological abnormalities to improve CCC prognosis, opening an opportunity for a better quality of life for Chagas' disease (CD) patients.

  17. 76 FR 46853 - International Business Machines Corporation, ITD Business Unit, Division 7, E-mail and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ..., applicable to workers of International Business Machines Corporation (IBM), ITD Business Unit, Division 7, E... Machines Corporation (IBM), ITD Business Unit, Division 7, E-mail and Collaboration ] Group, including... Employment and Training Administration International Business Machines Corporation, ITD Business...

  18. 78 FR 48537 - Small Business Innovation Research and Small Business Technology Transfer Programs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... ADMINISTRATION Small Business Innovation Research and Small Business Technology Transfer Programs... Administration (SBA) is publishing the Small Business Innovation Research (SBIR) and Small Business Technology... Business Administration, 409 Third Street SW., Washington, DC 20416; or send an email to...

  19. Simulation in JFL: Business Writing

    ERIC Educational Resources Information Center

    Fukushima, Tatsuya

    2007-01-01

    This article discusses a simulation wherein learners of Japanese as a Foreign Language (JFL) in a business writing course at an American university are assigned tasks to write a series of business letters based on situations that are likely to occur in actual business settings. After an overview of the theoretical background, this article…

  20. The Business Approach to Training.

    ERIC Educational Resources Information Center

    Williams, Teresa; Green, Adrian

    This self-study book concentrates on enabling trainers to talk and think in a business-related way, use business concepts and terminology, and translate training and development ideas into a business setting. Each part contains activities to enable users to study their training and development function and organization and consider how to use the…

  1. Business Books: Best of 2008

    ERIC Educational Resources Information Center

    Cords, Sarah Statz

    2009-01-01

    In 2008, as business increasingly became the news, business publishing showed a growing awareness of the big picture, putting out fewer personality-driven titles. In this list, one will see that business histories embrace recent technological innovation as much as longevity. The best management/HR books look at the big picture through pushing…

  2. Measuring Entrepreneurship in Business Schools

    ERIC Educational Resources Information Center

    Hazeldine, Mary; Miles, Morgan

    2007-01-01

    The recent positions of the Association to Advance Collegiate Schools of Business (AACSB) and the European Foundation for Management Developments (EQUIS) on the value of entrepreneurship suggest a more entrepreneurial perspective in a business school's culture and strategic processes for obtaining and sustaining a business school's reputation. The…

  3. Valuing Your Child Care Business.

    ERIC Educational Resources Information Center

    Linsmeier, Dave; Richards, Dick; Routzong, Ed

    2003-01-01

    Offers guidelines for putting a monetary value on a child care business. Discusses reasons for valuing the business, types of valuations (book, liquidation, and fair market), fair market valuation formulas, the corporate valuation, valuing assets included in a sale, and using experts. Also offers several tips for selling a child care business. (EV)

  4. Library Study Guide for Business.

    ERIC Educational Resources Information Center

    Steidinger, Jana Reeg; Trzebiatowski, Elaine

    This library study guide was designed for business marketing students at the University of Wisconsin, Stout. The guide, and its accompanying exercises, were developed as an alternative to providing library instruction to approximately 150 business marketing students each semester. The guide introduces students to basic business reference sources…

  5. The Business of Governing Schools

    ERIC Educational Resources Information Center

    Gann, Nigel

    2015-01-01

    In September 2015, the Secretary of State for Education asked for more business involvement in schools, and in particular for business leaders' help to improve failing schools. This article questions the twenty-year campaign by all governments to engage business expertise and values in the governance of schools.

  6. Real Language Meets Real Business

    ERIC Educational Resources Information Center

    Muirhead, Muirhead; Schechter, Sarah

    2016-01-01

    The Real Business Language Challenge was a collaborative pilot project between Coca-Cola Enterprises (CCE) and Routes into Languages East for Year 9 and 10 pupils. It was based on CCE's award-winning Real Business Challenge, part of its highly acclaimed education programme. The Real Business Language Challenge transformed the project into a…

  7. Clean Energy Business Plan Competition

    SciTech Connect

    Maxted, Sara Jane; Lojewski, Brandon; Scherson, Yaniv

    2012-01-01

    Top Students Pitch Clean Energy Business Plans The six regional finalists of the National Clean Energy Business Plan Competition pitched their business plans to a panel of judges June 13 in Washington, D.C. The expert judges announced NuMat Technologies from Northwestern University as the grand prize winner.

  8. Clean Energy Business Plan Competition

    ScienceCinema

    Maxted, Sara Jane; Lojewski, Brandon; Scherson, Yaniv

    2016-07-12

    Top Students Pitch Clean Energy Business Plans The six regional finalists of the National Clean Energy Business Plan Competition pitched their business plans to a panel of judges June 13 in Washington, D.C. The expert judges announced NuMat Technologies from Northwestern University as the grand prize winner.

  9. Business and International Education Program

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    This paper presents an overview of the Business and International Education Program of the International Education Programs Service (IEPS). This program provides funds to institutions of higher education that enter into an agreement with a trade association, a business, or both for the purpose of improving business curriculum and as a means of…

  10. Hispanic Women Small Business Owners.

    ERIC Educational Resources Information Center

    Sarason, Yolanda; Koberg, Christine

    1994-01-01

    A survey of 22 Hispanic women who owned small businesses in a western state found that most were located in metropolitan areas, were new to business ownership, had started the business themselves, engaged in "miscellaneous services," and generated lower than average revenues. Respondents were similar to nonminority owners in educational…

  11. Are E-Businesses Trustworthy?

    ERIC Educational Resources Information Center

    Hulsey, John D.

    2010-01-01

    This study uses a quantitative approach to evaluate the trustworthiness of e-businesses as measured by the E-business Trustworthy Index, EBTI, developed as part of this research. The problem is that despite the importance of e-business trustworthiness and the findings from many studies, there are few if any objective measures that evaluate the…

  12. Interpreting correlations in biosequences

    NASA Astrophysics Data System (ADS)

    Herzel, H.; Trifonov, E. N.; Weiss, O.; Große, I.

    Understanding the complex organization of genomes as well as predicting the location of genes and the possible structure of the gene products are some of the most important problems in current molecular biology. Many statistical techniques are used to address these issues. A central role among them play correlation functions. This paper is based on an analysis of the decay of the entire 4×4 dimensional covariance matrix of DNA sequences. We apply this covariance analysis to human chromosomal regions, yeast DNA, and bacterial genomes and interpret the three most pronounced statistical features - long-range correlations, a period 3, and a period 10-11 - using known biological facts about the structure of genomes. For example, we relate the slowly decaying long-range G+C correlations to dispersed repeats and CpG islands. We show quantitatively that the 3-basepair-periodicity is due to the nonuniformity of the codon usage in protein coding segments. We finally show that periodicities of 10-11 basepairs in yeast DNA originate from an alternation of hydrophobic and hydrophilic amino acids in protein sequences.

  13. Summary and interpretive synthesis

    SciTech Connect

    1995-05-01

    This chapter summarizes the major advances made through our integrated geological studies of the Lisburne Group in northern Alaska. The depositional history of the Lisburne Group is discussed in a framework of depositional sequence stratigraphy. Although individual parasequences (small-scale carbonate cycles) of the Wahoo Limestone cannot be correlated with certainty, parasequence sets can be interpreted as different systems tracts within the large-scale depositional sequences, providing insights on the paleoenvironments, paleogeography and platform geometry. Conodont biostratigraphy precisely established the position of the Mississippian-Pennsylvanian boundary within an important reference section, where established foraminiferal biostratigraphy is inconsistent with respect to conodont-based time-rock boundaries. However, existing Carboniferous conodont zonations are not readily applicable because most zonal indicators are absent, so a local zonation scheme was developed. Diagenetic studies of the Lisburne Group recognized nineteen subaerial exposure surfaces and developed a cement stratigraphy that includes: early cements associated with subaerial exposure surfaces in the Lisburne Group; cements associated with the sub-Permian unconformity; and later burial cements. Subaerial exposure surfaces in the Alapah Limestone are easily explained, being associated with peritidal environments at the boundaries of Sequence A. The Lisburne exposed in ANWR is generally tightly cemented and supermature, but could still be a good reservoir target in the adjacent subsurface of ANWR given the appropriate diagenetic, deformational and thermal history. Our ongoing research on the Lisburne Group will hopefully provide additional insights in future publications.

  14. New Directions for the Business Curriculum.

    ERIC Educational Resources Information Center

    Dudley, Sid C.; And Others

    1995-01-01

    Restructuring, downsizing, small business growth, and changing employment opportunities necessitate reexamination of business curricula. A cross-functional curriculum should provide a general education foundation, a common body of business knowledge, and business specializations relevant to tomorrow's workplace. (SK)

  15. 48 CFR 970.1907 - Subcontracting with Small Business, Small Disadvantaged Business and Woman-Owned Small Business...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Business, Small Disadvantaged Business and Woman-Owned Small Business Concerns. 970.1907 Section 970.1907... MANAGEMENT AND OPERATING CONTRACTS Small, Small Disadvantaged and Women-Owned Small Business Concerns 970.1907 Subcontracting with Small Business, Small Disadvantaged Business and Woman-Owned Small...

  16. Future Trends in Business Travel Decision Making

    NASA Technical Reports Server (NTRS)

    Mason, Keith J.

    2002-01-01

    This research surveys twenty large companies and their travellers to identify and evaluate the effects of pressures on the business travel market in the future. The influence of the following areas on the decision making process are addressed: (1) Corporate travel policies and increasing professionalism in corporate purchasing; (2) The development of global strategic airline alliances; (3) The emergence of low cost airlines on short haul markets; and (4) The development of internet based booking tools and travel agency IT. The survey shows differences in views between travel managers, and travellers with regard to corporate travel policies. While travel managers see policy rules, travellers interpret these as guidelines, indicating travel managers will need to take further actions to exercise true control of travel budgets. The data shows that companies are more likely to prescribe a class of airline ticket, than the choice of airline itself. Corporate hierarchical bias in travel policies is still common both for short and particularly long haul flying. Other findings show that while travel managers believe that their companies are likely to sign global deals with strategic airline groups within a five year period in a bid to consolidating spending, they also believe that nearly a third of short haul flying will be taken with low cost carriers, indicating further penetration in this business travel market by these carriers. The paper also provides other predictions about the business travel market, based on the survey findings.

  17. Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir.

    PubMed

    Hong, Eun-Hye; Song, Jae-Hyoung; Shim, Aeri; Lee, Bo-Ra; Kwon, Bo-Eun; Song, Hyuk-Hwan; Kim, Yeon-Jeong; Chang, Sun-Young; Jeong, Hyeon Gun; Kim, Jong Geal; Seo, Sang-Uk; Kim, HyunPyo; Kwon, YongSoo; Ko, Hyun-Jeong

    2015-01-01

    Several anti-influenza drugs that reduce disease manifestation exist, and although these drugs provide clinical benefits in infected patients, their efficacy is limited by the emergence of drug-resistant influenza viruses. In the current study, we assessed the therapeutic strategy of enhancing the antiviral efficacy of an existing neuraminidase inhibitor, oseltamivir, by coadministering with the leaf extract from Hedera helix L, commonly known as ivy. Ivy extract has anti-inflammatory, antibacterial, antifungal, and antihelminthic properties. In the present study, we investigated its potential antiviral properties against influenza A/PR/8 (PR8) virus in a mouse model with suboptimal oseltamivir that mimics a poor clinical response to antiviral drug treatment. Suboptimal oseltamivir resulted in insufficient protection against PR8 infection. Oral administration of ivy extract with suboptimal oseltamivir increased the antiviral activity of oseltamivir. Ivy extract and its compounds, particularly hedrasaponin F, significantly reduced the cytopathic effect in PR8-infected A549 cells in the presence of oseltamivir. Compared with oseltamivir treatment alone, coadministration of the fraction of ivy extract that contained the highest proportion of hedrasaponin F with oseltamivir decreased pulmonary inflammation in PR8-infected mice. Inflammatory cytokines and chemokines, including tumor necrosis factor-alpha and chemokine (C-C motif) ligand 2, were reduced by treatment with oseltamivir and the fraction of ivy extract. Analysis of inflammatory cell infiltration in the bronchial alveolar of PR8-infected mice revealed that CD11b+Ly6G+ and CD11b+Ly6Cint cells were recruited after virus infection; coadministration of the ivy extract fraction with oseltamivir reduced infiltration of these inflammatory cells. In a model of suboptimal oseltamivir treatment, coadministration of ivy extract fraction that includes hedrasaponin F increased protection against PR8 infection that could be

  18. Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir

    PubMed Central

    Shim, Aeri; Lee, Bo-Ra; Kwon, Bo-Eun; Song, Hyuk-Hwan; Kim, Yeon-Jeong; Chang, Sun-Young; Jeong, Hyeon Gun; Kim, Jong Geal; Seo, Sang-Uk; Kim, HyunPyo; Kwon, YongSoo; Ko, Hyun-Jeong

    2015-01-01

    Several anti-influenza drugs that reduce disease manifestation exist, and although these drugs provide clinical benefits in infected patients, their efficacy is limited by the emergence of drug-resistant influenza viruses. In the current study, we assessed the therapeutic strategy of enhancing the antiviral efficacy of an existing neuraminidase inhibitor, oseltamivir, by coadministering with the leaf extract from Hedera helix L, commonly known as ivy. Ivy extract has anti-inflammatory, antibacterial, antifungal, and antihelminthic properties. In the present study, we investigated its potential antiviral properties against influenza A/PR/8 (PR8) virus in a mouse model with suboptimal oseltamivir that mimics a poor clinical response to antiviral drug treatment. Suboptimal oseltamivir resulted in insufficient protection against PR8 infection. Oral administration of ivy extract with suboptimal oseltamivir increased the antiviral activity of oseltamivir. Ivy extract and its compounds, particularly hedrasaponin F, significantly reduced the cytopathic effect in PR8-infected A549 cells in the presence of oseltamivir. Compared with oseltamivir treatment alone, coadministration of the fraction of ivy extract that contained the highest proportion of hedrasaponin F with oseltamivir decreased pulmonary inflammation in PR8-infected mice. Inflammatory cytokines and chemokines, including tumor necrosis factor-alpha and chemokine (C-C motif) ligand 2, were reduced by treatment with oseltamivir and the fraction of ivy extract. Analysis of inflammatory cell infiltration in the bronchial alveolar of PR8-infected mice revealed that CD11b+Ly6G+ and CD11b+Ly6Cint cells were recruited after virus infection; coadministration of the ivy extract fraction with oseltamivir reduced infiltration of these inflammatory cells. In a model of suboptimal oseltamivir treatment, coadministration of ivy extract fraction that includes hedrasaponin F increased protection against PR8 infection that could be

  19. Designing the IDS business portfolio.

    PubMed

    Etchen, L L; Bouton, J L

    2000-01-01

    The business-value model is a strategic and business decision-making tool that can help integrated delivery systems (IDSs) evaluate the relative value that their individual businesses contribute to their overall systems. To use the model, IDSs first need to identify their individual business lines using criteria such as scope, size, marketability, operations, and competition. Businesses then are categorized as core, continuum, cash, or complementary based on four criteria: system purpose, size as reflected by annual revenue, competitive position, and level of profitability. Standards for these criteria should be set by the IDS in accordance with its market circumstances.

  20. AGATE animation - business theme

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Business jet 3 of 6. Advanced General Aviation Technology Experiment (AGATE). NASA has selected a team of industry partners to help develop a 'highway in the sky' system, a key element of the government-industry effort to revitalize general aviation in the United States. The team will complete hardware and software development of a totally new concept for presenting critical flight path guidance information to the pilot. The cockpit display system will include a computer-drawn highway that the pilot follows to a pre-programmed destination. The highway will be drawn on a highly intuitive, low-cost flat panel display -- the primary flight display of the future -- that will displace decades-old 'steam gauge' instrumentation. Image from AGATE 'business jet' video animation.

  1. Exploratory study on the impact of switching to nilotinib in 18 patients with chronic myeloid leukemia in chronic phase with suboptimal response to imatinib

    PubMed Central

    Ailawadhi, Sikander; Akard, Luke P.; Miller, Carole B.; Jillella, Anand; DeAngelo, Daniel J.; Ericson, Solveig G.; Lin, Felice; Warsi, Ghulam; Radich, Jerald

    2016-01-01

    Background: The phase II, exploratory, open-label Exploring Nilotinib BCR-ABL Effects (ENABL) study [ClinicalTrials.gov identifier: NCT00644878] assessed the impact of switching to nilotinib therapy in patients with chronic myeloid leukemia in chronic phase (CML-CP) who had a suboptimal molecular response with imatinib. Methods: Patients with CML-CP who had previously achieved a complete cytogenetic response (CCyR), but had a suboptimal molecular response, with frontline imatinib therapy (N = 18) were assigned to receive nilotinib 300 mg twice daily. The primary endpoint was the change in BCR-ABL1 transcript levels from baseline after 12 months; rates of major molecular response (MMR) and safety were also assessed. Results: At 3 months after switching to nilotinib, 10 of 17 (59%) evaluable patients had achieved MMR. At 12 months, 9 of 12 (75%) evaluable patients had achieved MMR, and the median BCR-ABL1 level among all patients remaining in the study was 0.020% on the International Scale (IS), equivalent to a 3.7-log reduction from the standardized IS baseline (primary endpoint). Adverse events (AEs) were typically grade 1/2 and manageable with dose interruptions. A total of three patients experienced serious study drug-related AEs, including pancreatitis, bradycardia, and vertigo. No deaths were reported. Conclusions: Overall, results from this exploratory study suggest that switching to nilotinib due to suboptimal molecular response with imatinib can result in improved molecular response for patients with CML-CP. PMID:28042454

  2. Switching to nilotinib in patients with chronic myeloid leukemia in chronic phase with molecular suboptimal response to frontline imatinib: SENSOR final results and BIM polymorphism substudy.

    PubMed

    Miyamura, Koichi; Miyamoto, Toshihiro; Tanimoto, Mitsune; Yamamoto, Kazuhito; Kimura, Shinya; Kawaguchi, Tatsuya; Matsumura, Itaru; Hata, Tomoko; Tsurumi, Hisashi; Saito, Shigeki; Hino, Masayuki; Tadokoro, Seiji; Meguro, Kuniaki; Hyodo, Hideo; Yamamoto, Masahide; Kubo, Kohmei; Tsukada, Junichi; Kondo, Midori; Aoki, Makoto; Okada, Hikaru; Yanada, Masamitsu; Ohyashiki, Kazuma; Taniwaki, Masafumi

    2016-12-01

    Optimal management of patients with chronic myeloid leukemia in chronic phase with suboptimal molecular response (MR) to frontline imatinib is undefined. We report final results from SENSOR, which evaluated efficacy/safety of nilotinib in this setting. A substudy assessed whether BIM polymorphisms impacted response to nilotinib. In this single-arm, multicenter study, Japanese patients with suboptimal MR per European LeukemiaNet 2009 criteria (complete cytogenetic response, but not major MR [MMR]) after ≥18 months of frontline imatinib received nilotinib 400mg twice daily for 24 months. MR, BCR-ABL1 mutations/variants, and BIM polymorphisms were evaluated in a central laboratory. Primary endpoint was the MMR rate at 12 months (null hypothesis of 40%). Of 45 patients (median exposure, 22.08 months), 39 completed the study and six discontinued. At 12 and 24 months, 51.1% (95% CI, 35.8%-66.3%) and 66.7% (95% CI, 51.0%-80.0%) achieved MMR, respectively. Cumulative MMR incidence by 24 months was 75.6%. Of 40 patients analyzed, 10 of 12 (83.3%) with and 17 of 28 (60.7%) without BIM polymorphisms achieved MMR at 24 months. The safety profile was manageable with dose reductions and interruptions. Nilotinib provided clinical benefit for patients with suboptimal response to imatinib, and BIM polymorphisms did not influence MMR achievement. ClinicalTrials.gov: NCT01043874.

  3. Small Business Innovations

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The purpose of QASE RT is to enable system analysts and software engineers to evaluate performance and reliability implications of design alternatives. The program resulted from two Small Business Innovation Research (SBIR) projects. After receiving a description of the system architecture and workload from the user, QASE RT translates the system description into simulation models and executes them. Simulation provides detailed performance evaluation. The results of the evaluations are service and response times, offered load and device utilizations and functional availability.

  4. Small Business Innovations (MISER)

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Lightwave Electronics Corporation, Mountain View, CA, developed the Series 120 and 122 non-planner diode pumped ring lasers based on a low noise ring laser with voltage tuning that they delivered to Jet Propulsion Laboratory under a Small Business Innovation Research (SBIR) contract. The voltage tuning feature allows "phase-locking" the lasers, making them "electronic," similar to radio and microwave electronic oscillators. The Series 120 and 122 can be applied to fiber sensing, coherent communications and laser radar.

  5. Business Opportunities Guide

    DTIC Science & Technology

    1987-01-01

    Communications (C) systems necessary for tomorrow’s Air Foice can only be developed by a stronq’ESD/ industry team. Our first Business Opportunities Guide...contracted to produce prototypes, engineering models, or schedule estimates. The best of those proposals then advance to engineering development and award...DME source. The purpose of the Military MLS Avionics Program is to develop very high reliability MLS avionics for use by military aircraft of all the

  6. Business Development Process

    DTIC Science & Technology

    2001-10-31

    entity’s real estate situation and condition for use by 17 customers including (but not limited to) the business entity. 18 Information is processed to...the score to provide a well- 3 rounded picture of a particular real estate situation. 4 Stratmann discloses a method for assisting an individual in...identify a potential 9 flaw in the opportunity analysis . These criteria include whether 10 the process is dealing with a real customer, if it is

  7. Small Business Innovations (Photodetector)

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Epitaxx, Inc. of Princeton, NJ, developed the Epitaxx Near Infrared Room Temperature Indium-Gallium-Arsenide (InGaAs) Photodetector based on their Goddard Space Flight Center Small Business Innovation Research (SBIR) contract work to develop a linear detector array for satellite imaging applications using InGaAs alloys that didn't need to be cooled to (difficult and expensive) cryogenic temperatures. The photodetectors can be used for remote sensing, fiber optic and laser position-sensing applications.

  8. Minority Ownership of Small Businesses: Instructional Handbook.

    ERIC Educational Resources Information Center

    Bureau of Adult, Vocational, and Technical Education (DHEW/OE), Washington, DC.

    This handbook is intended to provide supplementary instruction on basic business techniques for adult minority students in business education. Relevant information on how to start a business is provided by means of actual business situations and problems encountered in 30 recent minority business ventures. Focusing on business procedures and…

  9. 13 CFR 102.7 - Business information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Business information. 102.7 Section 102.7 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RECORD DISCLOSURE AND PRIVACY Disclosure of Information § 102.7 Business information. (a) In general. Business information provided to...

  10. 13 CFR 102.7 - Business information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Business information. 102.7 Section 102.7 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RECORD DISCLOSURE AND PRIVACY Disclosure of Information § 102.7 Business information. (a) In general. Business information provided to...

  11. 13 CFR 102.7 - Business information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Business information. 102.7 Section 102.7 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RECORD DISCLOSURE AND PRIVACY Disclosure of Information § 102.7 Business information. (a) In general. Business information provided to...

  12. 13 CFR 102.7 - Business information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Business information. 102.7 Section 102.7 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RECORD DISCLOSURE AND PRIVACY Disclosure of Information § 102.7 Business information. (a) In general. Business information provided to...

  13. 13 CFR 102.7 - Business information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Business information. 102.7 Section 102.7 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RECORD DISCLOSURE AND PRIVACY Disclosure of Information § 102.7 Business information. (a) In general. Business information provided to...

  14. Small Business Innovations

    NASA Technical Reports Server (NTRS)

    1994-01-01

    A Small Business Innovation Research (SBIR) contract resulted in a series of commercially available lasers, which have application in fiber optic communications, difference frequency generation, fiber optic sensing and general laboratory use. Developed under a Small Business Innovation Research (SBIR) contract, the Phase Doppler Particles Analyzer is a non-disruptive, highly accurate laser-based method of determining particle size, number density, trajectory, turbulence and other information about particles passing through a measurement probe volume. The system consists of an optical transmitter and receiver, signal processor and computer with data acquisition and analysis software. A variety of systems are offered for applications including spray characterization for paint, and agricultural and other sprays. The Microsizer, a related product, is used in medical equipment manufacturing and analysis of contained flows. High frequency components and subsystems produced by Millitech Corporation are marketed for both research and commercial use. These systems, which operate in the upper portion of the millimeter wave, resulted from a number of Small Business Innovation Research (SBIR) projects. By developing very high performance mixers and multipliers, the company has advanced the state of the art in sensitive receiver technology. Components are used in receivers and transceivers for monitoring chlorine monoxides, ozone, in plasma characterization and in material properties characterization.

  15. Business process optimization for RHIOs.

    PubMed

    Soti, Praveen; Pandey, Seema

    2007-01-01

    Implementation of an electronic health record (EHR) network entails significant changes in the business processes of participating organizations. Business process management, increased automation, process optimization, user training and end-user adoption together form the keys to success with an EHR. Redesigned processes should be mapped to benefit lines and performance indicators, and monitored continuously to identify improvement opportunities. It is important the new business work flows should match, if not exceed, the existing benchmarks for performance. Business process redesign is all the more challenging in the context of regional health information organizations (RHIOs), as the business processes of the EHR network have to be aligned with existing process flows of several organizations, each with its own preferences and specific requirements. Even so, most of the discrete individual processes have to be converged, streamlined, assimilated and optimized in the redesigned business processes. This paper proposes a methodology for business process redesign and optimization for RHIOs.

  16. China Accreditation Test for Translators and Interpreters (CATTI): Test Review Based on the Language Pairing of English and Chinese

    ERIC Educational Resources Information Center

    Zhao, Hulin; Gu, Xiangdong

    2016-01-01

    Test Purpose: The CATTI aims to measure competence in translation and interpreting (including simultaneous and consecutive interpreting) between Chinese and seven foreign languages: English, Japanese, French, Arabic, Russian, German, or Spanish. The test is intended to cover a wide range of domains including business, government, academia, and…

  17. Components of Simultaneous Interpreting: Comparing Interpreting with Shadowing and Paraphrasing

    ERIC Educational Resources Information Center

    Christoffels, Ingrid K.; de Groot, Annette M. B.

    2004-01-01

    Simultaneous interpreting is a complex task where the interpreter is routinely involved in comprehending, translating and producing language at the same time. This study assessed two components that are likely to be major sources of complexity in SI: The simultaneity of comprehension and production, and transformation of the input. Furthermore,…

  18. On the design of optimal dynamic experiments for parameter estimation of a Ratkowsky-type growth kinetics at suboptimal temperatures.

    PubMed

    Bernaerts, K; Versyck, K J; Van Impe, J F

    2000-03-10

    It is generally known that accurate model building, i.e., proper model structure selection and reliable parameter estimation, constitutes an essential matter in the field of predictive microbiology, in particular, when integrating these predictive models in food safety systems. In this context, Versyck et al. (1999) have introduced the methodology of optimal experimental design techniques for parameter estimation within the field. Optimal experimental design focuses on the development of optimal input profiles such that the resulting rich (i.e., highly informative) experimental data enable unique model parameter estimation. As a case study, Versyck et al. (1999) [Versyck, K., Bernaerts, K., Geeraerd, A.H., Van Impe, J.F., 1999. Introducing optimal experimental design in predictive modeling: a motivating example. Int. J. Food Microbiol., 51(1), 39-51] have elaborated the estimation of Bigelow inactivation kinetics parameters (in a numerical way). Opposed to the classic (static) experimental approach in predictive modelling, an optimal dynamic experimental setup is presented. In this paper, the methodology of optimal experimental design or parameter estimation is applied to obtain uncorrelated estimates of the square root model parameters [Ratkowsky, D.A., Olley, J., McMeekin, T.A., Ball, A., 1982. Relationship between temperature and growth rate of bacterial cultures. J. Bacteriol. 149, 1-5] describing the effect of suboptimal growth temperatures on the maximum specific growth rate of microorganisms. These estimates are the direct result of fitting a primary growth model to cell density measurements as a function of time. Apart from the design of an optimal time-varying temperature profile based on a sensitivity study of the model output, an important contribution of this publication is a first experimental validation of this innovative dynamic experimental approach for uncorrelated parameter identification. An optimal step temperature profile, within the range of

  19. Work-Recreation Balance, Health-Promoting Lifestyles and Suboptimal Health Status in Southern China: A Cross-Sectional Study

    PubMed Central

    Wu, Shengwei; Xuan, Zhengzheng; Li, Fei; Xiao, Wei; Fu, Xiuqiong; Jiang, Pingping; Chen, Jieyu; Xiang, Lei; Liu, Yanyan; Nie, Xiaoli; Luo, Ren; Sun, Xiaomin; Kwan, Hiuyee; Zhao, Xiaoshan

    2016-01-01

    Suboptimal health status (SHS)—an intermediate state between health and illness—refers to functional somatic symptoms that are medically undiagnosed. Although SHS has become a great challenge for global public health, very little about its etiology and mechanisms are known. Work-recreation balance is a part of work−life balance, and is related to stress which greatly influences health status. We therefore carried out a cross-sectional investigation between 2012 and 2013 within a clustered sample of 24,475 individuals aged 15−60 years from a population in southern China. In so doing, we hoped to illuminate the associations between work-recreation balance conditions, healthy lifestyles, and SHS. Work-recreation balance conditions were categorically defined by frequency (“rarely, sometimes, or always”). Health-Promoting Lifestyle Profile (HPLP-II) was used to evaluate the level of healthy lifestyles, and the medical examination report and Sub-Health Measurement Scale V1.0 (SHMS V1.0) were both used to evaluate health status. The ratio of SHS (46.3%) is higher than health status (18.4%) or disease status (35.3%). Overall, 4.9% of respondents reported the lowest level of work-recreation balance, and they scored lower on both the HPLP-II and SHMS V1.0 compared with those who frequently maintained a work-recreation balance. Significant association was found between work-recreation balance behaviors and healthy lifestyles (p < 0.001) after demographic adjustment. In comparison with those reporting a frequent work-recreation balance, individuals whose work-recreation balance was categorically “rare” were 1.69 times as likely to develop SHS (odds ratio (OR): 1.69, 95% confidence interval (CI): 1.49–1.92), and those with infrequent work-recreation balance (“sometimes”) were 1.71 times more likely to develop SHS (OR: 1.71, 95% CI: 1.62–1.81). These findings suggest that work-recreation balance conditions are significantly associated with, and seem to be

  20. Udder infections with Staphylococcus aureus, Streptococcus dysgalactiae, and Streptococcus uberis at calving in dairy herds with suboptimal udder health.

    PubMed

    Lundberg, Å; Nyman, A-K; Aspán, A; Börjesson, S; Unnerstad, H Ericsson; Waller, K Persson

    2016-03-01

    Udder infections with Staphylococcus aureus, Streptococcus dysgalactiae, and Streptococcus uberis are common causes of bovine mastitis. To study these pathogens in early lactation, a 12-mo longitudinal, observational study was carried out in 13 herds with suboptimal udder health. The aims of the study were to investigate the occurrence of these pathogens and to identify if presence of the 3 pathogens, and of genotypes within the pathogens, differed with respect to herd, season, and parity. Quarter milk samples, collected at calving and 4 d in milk (DIM), were cultured for the 3 pathogens. Genotyping of staphylococcal and streptococcal isolates was performed using spa typing and pulsed-field gel electrophoresis, respectively. For each of the 3 pathogens, cows with an udder infection at calving or 4 DIM were allocated to 1 of 4 infection types: cleared (pathogen present only at calving), persistent (pathogen present in the same quarter at calving and 4 DIM), new (pathogen present only at 4 DIM), or cleared/new (pathogen present in 1 quarter at calving and in another quarter at 4 DIM). Associations between season or parity and overall occurrence of pathogens or infection types were determined using univariable mixed-effect logistic-regression models and the Fisher's exact test, respectively. The most commonly occurring pathogen was Staph. aureus, followed by Strep. dysgalactiae and Strep. uberis. Persistent infections were the most common infection type among Staph. aureus-infected cows, whereas cleared infections were the most common among Strep. dysgalactiae- and Strep. uberis-positive cows. The proportion of cows with persistent Staph. aureus infections and the proportion of cows having a Strep. uberis infection at calving or 4 DIM were higher in the multiparous cows than in primiparous cows. Infections with Strep. dysgalactiae were less common during the early housing season than during the late housing or pasture seasons, whereas persistent Strep. uberis

  1. Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial

    PubMed Central

    van Lelyveld, Steven F. L.; Otto, Sigrid A.; Richter, Clemens; Soetekouw, Robin; Prins, Jan M.; Brinkman, Kees; Mulder, Jan Willem; Kroon, Frank; Middel, Ananja; Symons, Jori; Wensing, Annemarie M. J.; Nijhuis, Monique; Borghans, José A. M.; Tesselaar, Kiki; Hoepelman, Andy I. M.

    2015-01-01

    Objective The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of different cART (combination antiretroviral therapy) intensification studies are conflicting. Therefore, we performed a 48-week placebo-controlled trial to determine the effect of maraviroc intensification on CD4+ T-cell counts and immune activation in these patients. Design Double-blind, placebo-controlled, randomized trial. Methods Major inclusion criteria were 1. CD4+ T-cell count <350 cells/μL while at least two years on cART or CD4+ T-cell count <200 cells/μL while at least one year on cART, and 2. viral suppression for at least the previous 6 months. HIV-infected patients were randomized to add maraviroc (41 patients) or placebo (44 patients) to their cART regimen for 48 weeks. Changes in CD4+ T-cell counts (primary endpoint) and other immunological parameters were modeled using linear mixed effects models. Results No significant differences for the modelled increase in CD4+ T-cell count (placebo 15.3 CD4+ T cells/μL (95% confidence interval (CI) [1.0, 29.5] versus maraviroc arm 22.9 CD4+ T cells/μL (95% CI [7.4, 38.5] p = 0.51) or alterations in the expression of markers for T-cell activation, proliferation and microbial translocation were found between the arms. However, maraviroc intensification did increase the percentage of CCR5 expressing CD4+ and CD8+ T-cells, and the plasma levels of the CCR5 ligand MIP-1β. In contrast, the percentage of ex-vivo apoptotic CD8+ and CD4+ T-cells decreased in the maraviroc arm. Conclusions Maraviroc intensification of cART did not increase CD4+ T-cell restoration or decrease immune activation as compared to placebo. However, ex-vivo T-cell apoptosis was decreased in the maraviroc arm. Trial Registration ClinicalTrials.gov NCT00875368 PMID:26208341

  2. Effect of cell immobilization on the growth dynamics of Salmonella Typhimurium and Escherichia coli at suboptimal temperatures.

    PubMed

    Smet, Cindy; Van Derlinden, Eva; Mertens, Laurence; Noriega, Estefanía; Van Impe, Jan F

    2015-09-02

    Predictive microbiology has recently acknowledged the impact of the solid(like) food structure on microbial behavior. The presence of this solid(like) structure causes microorganisms to grow as colonies and no longer planktonically as in liquid. In this paper, the growth dynamics of Salmonella Typhimurium and Escherichia coli were studied as a function of temperature, considering different growth morphologies, i.e., (i) planktonic cells, (ii) immersed colonies and (iii) surface colonies. For all three growth morphologies, both microorganisms were grown in petri dishes. While E. coli was grown under optimal pH and water activity (aw), for S. Typhimurium pH and aw were adapted to 5.5 and 0.990. In order to mimic a solid(like) environment, 5% (w/v) gelatin was added. All petri dishes were incubated under static conditions at temperatures in the range [8.0°C-22.0°C]. Cell density was determined via viable plate counting. This work demonstrates that the growth morphology (planktonic vs. colony) has a negligible effect on the growth dynamics as a function of temperature. The observation of almost equal growth rates for planktonic cultures and colonies is in contrast to literature where, mostly, a difference is observed, i.e., μplanktonic cells≥μimmersed colonies≥μsurface colonies. This difference might be due to shaking of the liquid culture in these studies, which results in a nutrient and oxygen rich environment, in contrast to the diffusion-limited gel system. Experiments also indicate that lag phases for solid(like) systems are similar to those for the planktonic cultures, as can be found in literature for similar growth conditions. Considering the maximum cell density, no clear trend was deducted for either of the microorganisms. This study indicates that the growth parameters in the suboptimal temperature range do not depend on the growth morphology. For the considered experimental conditions, models previously developed for liquid environments can be used

  3. Work-Recreation Balance, Health-Promoting Lifestyles and Suboptimal Health Status in Southern China: A Cross-Sectional Study.

    PubMed

    Wu, Shengwei; Xuan, Zhengzheng; Li, Fei; Xiao, Wei; Fu, Xiuqiong; Jiang, Pingping; Chen, Jieyu; Xiang, Lei; Liu, Yanyan; Nie, Xiaoli; Luo, Ren; Sun, Xiaomin; Kwan, Hiuyee; Zhao, Xiaoshan

    2016-03-19

    Suboptimal health status (SHS)-an intermediate state between health and illness--refers to functional somatic symptoms that are medically undiagnosed. Although- SHS has become a great challenge for global public health, very little about its etiology and mechanisms are known. Work-recreation balance is a part of work-life balance, and is related to stress which greatly influences health status. We therefore carried out a cross-sectional investigation between 2012 and 2013 within a clustered sample of 24,475 individuals aged 15-60 years from a population in southern China. In so doing, we hoped to illuminate the associations between work-recreation balance conditions, healthy lifestyles, and SHS. Work-recreation balance conditions were categorically defined by frequency ("rarely, sometimes, or always"). Health-Promoting Lifestyle Profile (HPLP-II) was used to evaluate the level of healthy lifestyles, and the medical examination report and Sub-Health Measurement Scale V1.0 (SHMS V1.0) were both used to evaluate health status. The ratio of SHS (46.3%) is higher than health status (18.4%) or disease status (35.3%). Overall, 4.9% of respondents reported the lowest level of work-recreation balance, and they scored lower on both the HPLP-II and SHMS V1.0 compared with those who frequently maintained a work-recreation balance. Significant association was found between work-recreation balance behaviors and healthy lifestyles (p < 0.001) after demographic adjustment. In comparison with those reporting a frequent work-recreation balance, individuals whose work-recreation balance was categorically "rare" were 1.69 times as likely to develop SHS (odds ratio (OR): 1.69, 95% confidence interval (CI): 1.49-1.92), and those with infrequent work-recreation balance ("sometimes") were 1.71 times more likely to develop SHS (OR: 1.71, 95% CI: 1.62-1.81). These findings suggest that work-recreation balance conditions are significantly associated with, and seem to be accurate behavioral

  4. Negative effects of stress immediately before slaughter on pork quality are aggravated by suboptimal transport and lairage conditions.

    PubMed

    Hambrecht, E; Eissen, J J; Newman, D J; Smits, C H M; den Hartog, L A; Verstegen, M W A

    2005-02-01

    by any treatment. Comparisons with the "optimal" handling (short transport, long lairage, and minimal stress) revealed that, with regard to water-holding properties, the negative effects of high stress were aggravated by suboptimal transport and lairage conditions. High stress alone increased electrical conductivity by 56%, whereas high stress in combination with short lairage led to an 88% increase. However, high preslaughter stress contributed most and was the major factor responsible for reductions in pork quality.

  5. Business Training and Education Needs of Chiropractors

    PubMed Central

    Henson, Steve W; Pressley, Milton; Korfmann, Scott

    2008-01-01

    Objective: This report is an examination of the perceived need for business skills among chiropractors. Methods: An online survey was completed by 64 chiropractors. They assessed the need for business skills and current levels of business skills. Using this information, gaps in business skills are identified. Results: The need for business skills is broad, encompassing all major business functions. Existing business skills are well below needed levels. Conclusion: The chiropractic profession needs significantly greater business and practice management skills. The existing gap between needed business skills and existing skills suggests that current training and education programs are not providing adequate business skills training PMID:19043535

  6. Business owners' optimism and business performance after a natural disaster.

    PubMed

    Bronson, James W; Faircloth, James B; Valentine, Sean R

    2006-12-01

    Previous work indicates that individuals' optimism is related to superior performance in adverse situations. This study examined correlations after flooding for measures of business recovery but found only weak support (very small common variance) for business owners' optimism scores and sales recovery. Using traditional measures of recovery, in this study was little empirical evidence that optimism would be of value in identifying businesses at risk after a natural disaster.

  7. Beyond business process redesign: redefining Baxter's business network.

    PubMed

    Short, J E; Venkatraman, N

    1992-01-01

    Business process redesign has focused almost exclusively on improving the firm's internal operations. Although internal efficiency and effectiveness are important objectives, the authors argue that business network redesign--reconceptualizing the role of the firm and its key business processes in the larger business network--is of greater strategic importance. To support their argument, they analyze the evolution of Baxter's ASAP system, one of the most publicized but inadequately understood strategic information systems of the 1980s. They conclude by examining whether ASAP's early successes have positioned the firm well for the changing hospital supplies marketplace of the 1990s.

  8. Interpreting Recoil for Undergraduate Students

    ERIC Educational Resources Information Center

    Elsayed, Tarek A.

    2012-01-01

    The phenomenon of recoil is usually explained to students in the context of Newton's third law. Typically, when a projectile is fired, the recoil of the launch mechanism is interpreted as a reaction to the ejection of the smaller projectile. The same phenomenon is also interpreted in the context of the conservation of linear momentum, which is…

  9. Interpretative Decision Making in Research.

    ERIC Educational Resources Information Center

    Maitland-Gholson, Jane; Ettinger, Linda F.

    1994-01-01

    Asserts that all research is interpretive and that reality is constructed at every stage of a research project. Explores three research constructs: (1) role of the researcher; (2) research questions; and (3) underlying assumptions of the researcher. Presents and applies a foundation for an interpretative research framework. (CFR)

  10. Museum Docents' Understanding of Interpretation

    ERIC Educational Resources Information Center

    Neill, Amanda C.

    2010-01-01

    The purpose of this qualitative research study was to explore docents' perceptions of their interpretive role in art museums and determine how those perceptions shape docents' practice. The objective was to better understand how docents conceive of their role and what shapes the interpretation they give on tours to the public. The conceptual…

  11. Judging Dramatic Interpretation: Textual Considerations.

    ERIC Educational Resources Information Center

    Manchester, Bruce B.

    The recent growth in popularity among college students of dramatic interpretation in forensic competition justifies an examination of textual considerations and resultant criteria important to the evaluation of dramatic literature. The first considerations of the student contemplating the dramatic interpretation event are the selection of material…

  12. Interpreting Association from Graphical Displays

    ERIC Educational Resources Information Center

    Fitzallen, Noleine

    2016-01-01

    Research that has explored students' interpretations of graphical representations has not extended to include how students apply understanding of particular statistical concepts related to one graphical representation to interpret different representations. This paper reports on the way in which students' understanding of covariation, evidenced…

  13. Remote sensing and image interpretation

    NASA Technical Reports Server (NTRS)

    Lillesand, T. M.; Kiefer, R. W. (Principal Investigator)

    1979-01-01

    A textbook prepared primarily for use in introductory courses in remote sensing is presented. Topics covered include concepts and foundations of remote sensing; elements of photographic systems; introduction to airphoto interpretation; airphoto interpretation for terrain evaluation; photogrammetry; radiometric characteristics of aerial photographs; aerial thermography; multispectral scanning and spectral pattern recognition; microwave sensing; and remote sensing from space.

  14. AIDS is your business.

    PubMed

    Rosen, Sydney; Simon, Jonathon; Vincent, Jeffrey R; MacLeod, William; Fox, Matthew; Thea, Donald M

    2003-02-01

    If your company operates in a developing country, AIDS is your business. While Africa has received the most attention, AIDS is also spreading swiftly in other parts of the world. Russia and Ukraine had the fastest-growing epidemics last year, and many experts believe China and India will suffer the next tidal wave of infection. Why should executives be concerned about AIDS? Because it is destroying the twin rationales of globalization strategy-cheap labor and fast-growing markets--in countries where people are heavily affected by the epidemic. Fortunately, investments in programs that prevent infection and provide treatment for employees who have HIV/AIDS are profitable for many businesses--that is, they lead to savings that outweigh the programs' costs. Due to the long latency period between HIV infection and the onset of AIDS symptoms, a company is not likely to see any of the costs of HIV/AIDS until five to ten years after an employee is infected. But executives can calculate the present value of epidemic-related costs by using the discount rate to weigh each cost according to its expected timing. That allows companies to think about expenses on HIV/AIDS prevention and treatment programs as investments rather than merely as costs. The authors found that the annual cost of AIDS to six corporations in South Africa and Botswana ranged from 0.4% to 5.9% of the wage bill. All six companies would have earned positive returns on their investments if they had provided employees with free treatment for HIV/AIDS in the form of highly active antiretroviral therapy (HAART), according to the mathematical model the authors used. The annual reduction in the AIDS "tax" would have been as much as 40.4%. The authors' conclusion? Fighting AIDS not only helps those infected; it also makes good business sense.

  15. Small Business Innovations (Helicopters)

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The amount of engine power required for a helicopter to hover is an important, but difficult, consideration in helicopter design. The EHPIC program model produces converged, freely distorted wake geometries that generate accurate analysis of wake-induced downwash, allowing good predictions of rotor thrust and power requirements. Continuum Dynamics, Inc., the Small Business Innovation Research (SBIR) company that developed EHPIC, also produces RotorCRAFT, a program for analysis of aerodynamic loading of helicopter blades in forward flight. Both helicopter codes have been licensed to commercial manufacturers.

  16. Small Business Innovations

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The PER-Force Handcontroller was originally developed for the International Space Station under a Johnson Space Center Small Business Innovation Research (SBIR) contract. Produced by Cybernet Systems Corporation, the unit is a force-reflecting system that manipulates robots or objects by "feel." The Handcontroller moves in six degrees of freedom, with real and virtual reality forces simulated by a 3-D molecular modeling software package. It is used in molecular modeling in metallurgy applications, satellite docking research, and in research on military unmanned ground vehicles.

  17. Small Business Innovations (Cryostat)

    NASA Technical Reports Server (NTRS)

    1991-01-01

    General Pneumatics Corporation, Scottsdale, AZ, developed an anti- clogging cryostat that liquifies gases by expansion for high pressure through a nozzle to produce cryorefrigeration based on their Kennedy Space Center Small Business Innovation Research (SBIR) work to develop a Joule-Thomson (JT) expansion valve that is less susceptible to clogging by particles or condensed contaminants in the flow than a non-contaminating compressor in a closed cycle Linde-Hampson cryocooler used to generate cryogenic cooling for infrared sensors, super conductors, supercooled electronics and cryosurgery.

  18. Contemporary Interpretations of Robert Frank's "The Americans."

    ERIC Educational Resources Information Center

    Nesterenko, Alexander; Smith, C. Zoe

    1984-01-01

    Examines interpretation of Robert Frank's photographic essay (1) to discern the experiences evoked by the essay, (2) to establish the relationship between "projected" and "stated" interpretations, and (3) to determine the extent to which "stated" interpretations resemble "ideal" interpretations. (FL)

  19. Small Business at EPA Bulletin

    EPA Pesticide Factsheets

    A list of monthly bulletins that highlight information on Agency activities, rulemakings, and to share information about ongoing initiatives from the State Small Business Environmental Assistance Programs.

  20. Biopharma business models in Canada.

    PubMed

    March-Chordà, I; Yagüe-Perales, R M

    2011-08-01

    This article provides new insights into the different strategy paths or business models currently being implemented by Canadian biopharma companies. Through a case-study methodology, seven biopharma companies pertaining to three business models were analyzed, leading to a broad set of results emerging from the following areas: activity, business model and strategy; management and human resources; and R&D, technology and innovation strategy. The three business models represented were: model 1 (conventional biotech oriented to new drug development, radical innovation and search for discoveries); model 2 (development of a technology platform, usually in proteomics and bioinformatics); and model 3 (incremental innovation, with shorter and less risky development timelines).

  1. Encountering Science in the World: New Partnerships for Science Interpretation

    NASA Astrophysics Data System (ADS)

    Chambers, L. H.; Davis, A.; Paglierani, R.

    2014-12-01

    In 2000, while visiting Arches National Park in Utah, I had my first encounter with my science in the context of interpretation. During a ranger walk, a student intern at the park explained the concept of the radiation budget (for the desert surface, in her case) to the group of visitors. As a NASA scientist on the Clouds and the Earth's Radiant Energy System (CERES) science team, a team whose entire focus is on understanding Earth's energy budget, that visit made quite an impression on me: here was my science connected to the immediate and personal experience of that desert environment in a way that even my then 4-year-old daughter could take something from. Some years later, when I was invited to speak to a group of interpreters through the NASA/National Park Service "Earth to Sky" project, I jumped at the chance. Since then, I have had several opportunities to interact with interpreters, through additional "Earth to Sky" workshops as well as during a meeting of the National Association for Interpretation in my hometown. While I was invited to speak to these groups as a subject matter expert, I always learned at least as much as they did from the interaction. The standard practice for Earth to Sky is to pair presenters with an interpreter coach to help fine-tune the presentation for the audience - a valuable practice for presentations to any audience, if one can find an appropriate coach. The mere idea that interpretation is a profession, with research and guidelines and best practices, was completely eye opening to me at one of my first Earth to Sky events. So how to leverage interpretation for science communication? Rather than expecting busy scientists to learn everything about interpretation, a more effective approach is likely the one taken in the Earth to Sky workshop series, where scientists and interpreters work together for an intensive period to share information and approaches, and the interpreters are then able to take appropriate science elements to

  2. Developing "Green" Business Plans: Using Entrepreneurship to Teach Science to Business Administration Majors and Business to Biology Majors

    ERIC Educational Resources Information Center

    Letovsky, Robert; Banschbach, Valerie S.

    2011-01-01

    Biology majors team with business administration majors to develop proposals for "green" enterprise for a business plan competition. The course begins with a series of student presentations so that science students learn about the fundamentals of business, and business students learn about environmental biology. Then mixed biology-business student…

  3. Business is Beaming

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Terabeam has developed a Fiberless Optical(TM) Network that transmits broadband data from office buildings to the nation's wide-area networks (WANs), without digging up the streets. A key component of Terabeam's Fiberless Network is Large Aperture Holographic Optic technology, developed by Ralcon Development Lab, of Paradise, Utah. Ralcon developed the Holographic Optical Element (HOE) technology with assistance from a NASA Goddard Space Flight Center Small Business Innovation Research (SBIR) contract. Terabeam further developed the HOE technology and incorporated it into its Fiberless Optical Network-sending an immeasurable amount of information soaring overhead. Terabeam developed its Fiberless Optical Network using a proprietary HOE to transmit data. The unit is mounted near an office window and has the ability to beam safe, low-power, invisible data through the air at gigabits-per-second speeds to anywhere in the service area. Gigabits-per-second speeds are thousands of times faster than the speeds of current broadband transmissions. This allows businesses to connect to local-area networks (LANs) as well as WANs, in a quick and affordable manner.

  4. Interpreter services in pediatric nursing.

    PubMed

    Lehna, Carlee

    2005-01-01

    A critical part of every encounter between a pediatric nurse and a patient is obtaining accurate patient information. Unique obstacles are encountered when patients and their families have little or no understanding of the English language. Federal and state laws require health care systems that receive governmental funds to provide full language access to services. Both legal and ethical issues can arise when caring for non-English-speaking patients. Often, obtaining accurate patient information and a fully informed consent cannot be done without the use of an interpreter. The interpreter informs the family of all the risks and benefits of a specific avenue of care. When inappropriate interpreter services are used, such as when children in the family or other family members act as interpreters, concerns about accuracy, confidentiality, cultural congruency, and other issues may arise. The purpose of this article is to: (a) explore principles related to the use of medical interpreters, (b) examine different models of interpreter services, and (c) identify available resources to assist providers in accessing interpreter services (e.g., books, online resources, articles, and videos). The case study format will be used to illustrate key points.

  5. Enhancing International Business Education through Restructuring Business Schools

    ERIC Educational Resources Information Center

    Jain, Subhash C.

    2009-01-01

    Many scholars have found fault with the way business schools conduct their business (Pfeffer & Fong, 2002; Mintzberg, 2004; Bennis & O'Toole, 2005; Andrews & Tyson, 2006). This article argues that B-schools should overhaul their curriculum and encourage faculty to undertake research which is useful for practitioners. Suggestions are made for…

  6. Improving Business-IT Alignment through Business Architecture

    ERIC Educational Resources Information Center

    Li, Chingmei

    2010-01-01

    The business and Information Technology (IT) alignment issue has become one of the Top-10 IT management issues since 1980. IT has continually strived to achieve alignment with business goals and objectives. These IT efforts include ERP implementation to benefit from the best practices; data center consolidation and server virtualization to keep…

  7. Basic Business 20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of basic business. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials…

  8. Using Student Managed Businesses to Integrate the Business Curriculum

    ERIC Educational Resources Information Center

    Massad, Victor J.; Tucker, Joanne M.

    2009-01-01

    To teach business today requires that we go beyond classroom learning and encourage real world, cross-functional experiences and applied management decision-making. This paper describes an innovative approach that requires students to apply their function-specific knowledge of business, integrated with other functional areas, to an authentic…

  9. Facilitating Communication for Business. National Business Education Yearbook, No. 26.

    ERIC Educational Resources Information Center

    Scott, James Calvert, Ed.

    This yearbook suggests that businesspersons need to enhance their communication skills and that business educators have opportunities to fulfill that need. The yearbook contains 15 chapters organized in 5 parts. Part I discusses the importance of communication skills in the business world and identifies aspects of communication that…

  10. Consulting by Business College Academics: Lessons for Business Communication Courses

    ERIC Educational Resources Information Center

    Dave, Anish

    2009-01-01

    Business communication (BC) is a crucial aspect of management consulting. BC scholars have widely studied the relationship between BC and management consulting, including consulting by BC academics. A limited review of the studies of management consulting, including consulting done by business college academics, hereafter referred to simply as…

  11. Selecting a Business Major within the College of Business

    ERIC Educational Resources Information Center

    Roach, David W.; McGaughey, Ronald E.; Downey, James P.

    2012-01-01

    This study employed a survey in examining the important influences that shape a student's selection of a major in the College of Business (COB). In particular, it compared these influences, by major, to assess which items were most (and least) important to the students majoring in accounting, general business, finance, management, marketing, and…

  12. The Future of Family Business Education in UK Business Schools

    ERIC Educational Resources Information Center

    Collins, Lorna; Seaman, Claire; Graham, Stuart; Stepek, Martin

    2013-01-01

    Purpose: This practitioner paper aims to question basic assumptions about management education and to argue that a new paradigm is needed for UK business schools which embraces an oft neglected, yet economically vital, stakeholder group, namely family businesses. It seeks to pose the question of why we have forgotten to teach about family business…

  13. Business Unusual: Transforming Business School Curricula through Community Engagement

    ERIC Educational Resources Information Center

    Ehrich, Kristine; Ceranic, Tara; Liu, Judith

    2014-01-01

    As part of a Community Service-Learning Faculty Scholars Program, University of San Diego business faculty members created community engagement projects that connected students with the local community, exposed them to the realities of a global business world and showed the inherent value of community engagement. By utilizing service-learning and…

  14. The Use of Business Case Studies in Business German Classes.

    ERIC Educational Resources Information Center

    Schutte, Lilith

    The use of business case studies, defined as sophisticated models that present practical business problems and theoretical guidelines that can be used to solve the problems, is discussed. It is suggested that the main advantages of case studies are that they are usually more interesting to read than theoretical materials and they encourage student…

  15. Center for Navy Business Excellence: A Catalyst for Business Transformation

    DTIC Science & Technology

    2005-12-01

    warfighting) processes.150 Within the AEIOO, the Enterprise Solutions Competency Center ( ESCC ) exists to affect successful business IT...transformation. A multi-functional organization, ESCC is comprised of a core of resident experts augmented as necessary by an extended, virtual network. ESCC ...customers include Army Business Domains, Program Executive Offices (PEOs), Program Managers (PMs) and development teams. The ESCC serves three

  16. Small Business Marketing: A Workbook for Small Businesses in Oregon.

    ERIC Educational Resources Information Center

    Pryor, Chris

    This workbook was prepared for those interested in starting their own business, as well as business owners with many years experience who have never developed an organized promotional program. Introductory sections explain how to use the workbook and stress the need for promotion. The next sections outline the steps and ask users to respond to…

  17. Business continuity 2014: From traditional to integrated Business Continuity Management.

    PubMed

    Ee, Henry

    As global change continues to generate new challenges and potential threats to businesses, traditional business continuity management (BCM) slowly reveals its limitations and weak points to ensuring 'business resiliency' today. Consequently, BCM professionals also face the challenge of re-evaluating traditional concepts and introducing new strategies and industry best practices. This paper points to why traditional BCM is no longer sufficient in terms of enabling businesses to survive in today's high-risk environment. It also looks into some of the misconceptions about BCM and other stumbling blocks to establishing effective BCM today. Most importantly, however, this paper provides tips based on the Business Continuity Institute's (BCI) Good Practices Guideline (GPG) and the latest international BCM standard ISO 22301 on how to overcome the issues and challenges presented.

  18. AMT1;1 transgenic rice plants with enhanced NH4(+) permeability show superior growth and higher yield under optimal and suboptimal NH4(+) conditions.

    PubMed

    Ranathunge, Kosala; El-Kereamy, Ashraf; Gidda, Satinder; Bi, Yong-Mei; Rothstein, Steven J

    2014-03-01

    The major source of nitrogen for rice (Oryza sativa L.) is ammonium (NH4(+)). The NH4(+) uptake of roots is mainly governed by membrane transporters, with OsAMT1;1 being a prominent member of the OsAMT1 gene family that is known to be involved in NH4(+) transport in rice plants. However, little is known about its involvement in NH4(+) uptake in rice roots and subsequent effects on NH4(+) assimilation. This study shows that OsAMT1;1 is a constitutively expressed, nitrogen-responsive gene, and its protein product is localized in the plasma membrane. Its expression level is under the control of circadian rhythm. Transgenic rice lines (L-2 and L-3) overexpressing the OsAMT1;1 gene had the same root structure as the wild type (WT). However, they had 2-fold greater NH4(+) permeability than the WT, whereas OsAMT1;1 gene expression was 20-fold higher than in the WT. Analogous to the expression, transgenic lines had a higher NH4(+) content in the shoots and roots than the WT. Direct NH4(+) fluxes in the xylem showed that the transgenic lines had significantly greater uptake rates than the WT. Higher NH4(+) contents also promoted higher expression levels of genes in the nitrogen assimilation pathway, resulting in greater nitrogen assimilates, chlorophyll, starch, sugars, and grain yield in transgenic lines than in the WT under suboptimal and optimal nitrogen conditions. OsAMT1;1 also enhanced overall plant growth, especially under suboptimal NH4(+) levels. These results suggest that OsAMT1;1 has the potential for improving nitrogen use efficiency, plant growth, and grain yield under both suboptimal and optimal nitrogen fertilizer conditions.

  19. No improvement in suboptimal vitamin A status with a randomized, double-blind, placebo-controlled trial of vitamin A supplementation in children with sickle cell disease123

    PubMed Central

    Dougherty, Kelly A; Schall, Joan I; Kawchak, Deborah A; Green, Michael H; Ohene-Frempong, Kwaku; Zemel, Babette S; Stallings, Virginia A

    2012-01-01

    Background: Suboptimal vitamin A status is prevalent in children with type SS sickle cell disease (SCD-SS) and is associated with hospitalizations and poor growth and hematologic status. The supplemental vitamin A dose that optimizes suboptimal vitamin A status in this population is unknown. Objective: The efficacy of Recommended Dietary Allowance (RDA) doses (based on age and sex) of vitamin A (300, 400, or 600 μg retinyl palmitate/d) or vitamin A + zinc (10 or 20 mg zinc sulfate/d) compared with placebo to optimize vitamin A status was assessed in children aged 2.0–12.9 y with SCD-SS and a suboptimal baseline serum retinol concentration (<30 μg/dL). Design: In this randomized, double-blind, placebo-controlled trial, vitamin A status (serum retinol, prealbumin, retinol-binding protein, and relative-dose-response test) and disease-related illness events were assessed. Results: Twelve months of vitamin A supplementation at the doses recommended for healthy US children (based on age and sex) failed to improve serum retinol values in either group (vitamin A: n = 23; vitamin A + zinc: n = 18) compared with placebo (n = 21). By 12 mo, the increase (±SD) in serum retinol (3.6 ± 2.8 μg/dL) in those taking 600 μg vitamin A/d was significantly different from the decrease (±SD; −2.8 ± 2.4 μg/dL) in those taking 300 μg/d, which possibly suggests a dose-response relation (P < 0.05) with RDA doses. Conclusions: Compared with placebo, 12 mo of vitamin A supplementation at the RDA for healthy children did not improve serum retinol values in children with SCD-SS, which possibly suggests that higher doses are needed. However, the existence of alternative conclusions emphasizes the need for future research. PMID:22952182

  20. SU-E-T-448: Heightened Apical Positivity of 2-Year Post-Radiotherapy Biopsies Is Not Related to Suboptimal Dosimetry

    SciTech Connect

    Studenski, M; Stoyanova, R; Abramowitz, M; Dogan, N; Pollack, A

    2015-06-15

    Purpose: Previous research has demonstrated that following radiation therapy for prostate cancer, there is a relative increase in positive biopsies in the apex versus the rest of the prostate. The increase could be due to: 1) Inter-fraction apex motion or deformation, 2) Intra-fraction apex motion or deformation, 3) Suboptimal dose coverage in the apex, 4) Tissue composition in the apex and/or 5) Prostate size. In this initial study, the potential for suboptimal dose coverage in the apex was assessed by splitting the prostate planning target volume into the apex (inferior third) and remainder. Methods: 69 patients were selected from 303 patients treated on a clinical radiotherapy trial for prostate cancer. These patients were selected as they had both a localized (sextant template) 2-year post-treatment biopsy and 3D dose information. Of these patients, 10 had positive biopsies in the apex, 8 in the remainder and 11 in both locations. For all patients, the following dosimetric data was acquired from the apex dose volume histogram: Dmean, Dmax, Dmin, D95% and V100%. Unpaired, one-tailed t-tests were used to test for statistical significance (p < 0.05) between all dosimetric parameters for patients with positive versus negative apical biopsies. Additionally, D95% for the apex was plotted against D95% of the remainder. Results: There was no statistical difference for the selected apical dosimetric parameters for patients with positive versus negative biopsies (p-values > 0.05). No correlation was found between D95% (normalized to the prescription dose) for the apex and remainder (R{sup 2} = 0.0116). Conclusion: No correlation was found between positive apical biopsy and suboptimal dosimetric coverage. Current research is looking into inter-fraction apex motion and deformation as a potential source of the increased apical failure using daily CBCT images.

  1. Negotiated Syllabus in EAP Business English Courses.

    ERIC Educational Resources Information Center

    Boyle, Erlinda R.

    Negotiation of syllabus design and content in college-level business English is discussed, looking at three types: negotiation between teachers of business English, between teachers and students of business English, and between business English and content-area business teachers. Examples of practice from the Chinese University of Hong Kong are…

  2. 13 CFR 108.100 - Business form.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Business form. 108.100 Section 108.100 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Organizing A Nmvc Company § 108.100 Business form. A...

  3. 13 CFR 108.100 - Business form.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Business form. 108.100 Section 108.100 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Organizing A Nmvc Company § 108.100 Business form. A...

  4. 77 FR 56571 - Unincorporated Business Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ..., 621, 622, 623, and 630 RIN 3052-AC65 Unincorporated Business Entities AGENCY: Farm Credit... business entities (UBEs) organized under State law for certain business activities. For purposes of this... business entities, such as unincorporated business trusts, organized under State law. This rule does...

  5. 13 CFR 108.100 - Business form.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Business form. 108.100 Section 108.100 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Organizing A Nmvc Company § 108.100 Business form. A...

  6. 76 FR 74749 - Small Business Subcontracting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ...; ] SMALL BUSINESS ADMINISTRATION 13 CFR Parts 121 and 125 RIN 3245-AG22 Small Business Subcontracting AGENCY: U.S. Small Business Administration. ACTION: Proposed rule; reopening of comment period. SUMMARY... of the Small Business Jobs Act of 2010 (Jobs Act) pertaining to small business subcontracting....

  7. 13 CFR 108.100 - Business form.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Business form. 108.100 Section 108.100 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Organizing A Nmvc Company § 108.100 Business form. A...

  8. 13 CFR 108.100 - Business form.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Business form. 108.100 Section 108.100 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Organizing A Nmvc Company § 108.100 Business form. A...

  9. Department of the Navy Small Business Programs

    DTIC Science & Technology

    2014-08-13

    small business concerns and to women -owned small business concerns eligible under the Women -Owned Small Business Program. The dollar...2014 For All US-Based Women Owned Small Business Awards Over $ 200M Over $ 100M Over...Department of the Navy Small Business Programs Gold Coast August 13, 2014 Report Documentation Page Form ApprovedOMB No. 0704-0188

  10. Small Business Contracting in the United States and Europe: A Comparative Assessment

    DTIC Science & Technology

    2010-03-01

    Finance Corporation (RFC), the Smaller War Plants Corporation (SWPC), the Office of Small Business (OSB) in the US Department of Commerce, and the Small...decisions, Parking Brixen v. Gemeinde Brixen14 and ANAV v. Comune di Bari.15 The problem with this interpretation is the weakness of its supporting...duty‖ of the SBA ―to determine within any industry the concerns, firms, persons, corporations , partnerships, cooperatives, or other business

  11. 75 FR 20388 - International Business Machines Corporation, Global Technology Services Business Unit, Integrated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... Employment and Training Administration International Business Machines Corporation, Global Technology..., applicable to workers of International Business Machines Corporation, Global Technology Services Business..., New York, location of International Business Machines Corporation, Global Technology Services...

  12. 76 FR 21033 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration International Business Machines (IBM), Sales and Distribution Business... workers of International Business Machines (IBM), Sales and Distribution Business Unit, Global...

  13. 76 FR 5832 - International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration International Business Machines (IBM), Software Group Business Unit... at International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools...

  14. ENVIRONMENTAL PHOTOGRAPHIC INTERPRETATION CENTER (EPIC)

    EPA Science Inventory

    The Environmental Sciences Division (ESD) in the National Exposure Research Laboratory (NERL) of the Office of Research and Development provides remote sensing technical support including aerial photograph acquisition and interpretation to the EPA Program Offices, ORD Laboratorie...

  15. Car Troubles: An Interpretive Approach.

    ERIC Educational Resources Information Center

    Dawson, Leslie

    1995-01-01

    The growing amount of U.S. surface area being paved increases interpretive opportunities for teaching about the environmental impacts of automobiles. Provides methods and suggestions for educating high school students. Provides several computer graphics. (LZ)

  16. From Business to Technological German.

    ERIC Educational Resources Information Center

    Rockwood, H. M.

    Because many of the Georgia Institute of Technology students taking business German come from the sciences and engineering, the business language textbook used has been supplemented with more technologically oriented instructional materials. Highly technical texts are too advanced at the second year language learning stage, so one teacher selected…

  17. Business planning: learning by doing.

    PubMed

    Edmonstone, J; Havergal, M

    1992-01-01

    Places business planning in health care within a contextual and conceptual framework as a background to describing a development programme for the NHS in Scotland to facilitate the learning of key managers about the business planning process. The programme highlighted a "learning-by-doing" approach, whereby a number of change initiatives were triggered and future prospects for planning and learning identified.

  18. Creating School-Business Partnerships.

    ERIC Educational Resources Information Center

    Massachusetts State Dept. of Education, Quincy. Bureau of Student, Community and Adult Services.

    The six chapters in this publication describe the scope of school/business partnership activity in the Commonwealth of Massachusetts. Following the first chapter's introductory remarks, chapter 2 outlines methodology for the research project. Surveys were sent to superintendents of schools and to various businesses thought likely to be involved in…

  19. E-Learning in Business

    ERIC Educational Resources Information Center

    Schweizer, Heidi

    2004-01-01

    e-Learning is replacing face-to-face classroom instruction in a growing number of businesses, but what is the prospect for the continued proliferation of e-learning in business? On one hand, the quality of instruction, the cost-effectiveness of new technology, a supportive e-learning educational culture, an expansion of the Internet, an increase…

  20. Building a New Business Model

    ERIC Educational Resources Information Center

    Berkey, Lisa

    2009-01-01

    Monarch High School in Boulder, Colorado, is one of 25 schools piloting the High School of Business program, an accelerated business administration program developed by Columbus, Ohio-based MBA"Research" and Curriculum Center. This article describes the program which uses a heavily project-based pedagogy to teach a curriculum modeled…

  1. Effective use of business intelligence.

    PubMed

    Glaser, John; Stone, John

    2008-02-01

    Business intelligence--technology to manage and leverage an organization's data--can enhance healthcare organizations' financial and operational performance and quality of patient care. Effective BI management requires five preliminary steps: Establish business needs and value. Obtain buy-in from managers. Create an end-to-end vision. Establish BI governance. Implement specific roles for managing data quality.

  2. Business Education for Women Entrepreneurs.

    ERIC Educational Resources Information Center

    Kent, Calvin

    1983-01-01

    Summarizes the importance of entrepreneurship to the American economy, presents a profile of women small business owners, reviews the research pertaining to business education for women entrepreneurs, and indicates an agenda directed toward the educational needs of women venture initiators. (NRJ)

  3. The Business of Academic Support

    ERIC Educational Resources Information Center

    Potacco, Donna R.; De Young, Sandra

    2007-01-01

    Academia has traditionally avoided adopting the fast-paced, profit-oriented operational style that accompanies corporate culture. However, a business model can be successfully adapted to the unique needs of an academic institution, discipline, faculty, and students through the selective adoption of business principles. A classic marketing mix…

  4. Hispanic Business Ownership: A Profile.

    ERIC Educational Resources Information Center

    McKay, Emily Gantz

    Hispanic Americans owned nearly 250,000 U.S. businesses in 1982. This is only one-fourth of the number which would be expected given their proportion of the population. Most Hispanic businesses were small service or retail establishments with no paid employees. This report provides an analysis of survey data which were collected by the Bureau of…

  5. Business School Partnerships for Globalization

    ERIC Educational Resources Information Center

    Dixon, Rob; Slanickova, Daniela; Warwick, Philip

    2013-01-01

    International partnerships are an essential tool to enable business schools to internationalize their activities. They can lead to improved research, better more internationally relevant teaching, provide staff with an international perspective, and help prepare students for careers in global business. Using case studies of four of Durham…

  6. Teaching Social Media in Business

    ERIC Educational Resources Information Center

    McHaney, Roger; Warkentin, Merrill; Sachs, David; Pope, Michael Brian; Ormond, Dustin

    2015-01-01

    The ways people connect, interact, share, and communicate have changed due to recent developments in information technology. These developments, categorized as social media, have captured the attention of business executives, technologists, and education professionals alike, and have altered many business models. Additionally, the concept of…

  7. Why Business Backs Education Standards

    ERIC Educational Resources Information Center

    Goldberg, Milton; Traiman, Susan L.

    2001-01-01

    Business cares about education standards because the well-being of their companies and every American is at stake. In the international marketplace, says former Lockheed-Martin chief executive officer (CEO) Norman Augustine, the United States is involved in a "battle of the classrooms." As a result, business leaders believe that…

  8. Small Business. Lesson Plan Three.

    ERIC Educational Resources Information Center

    Dicke, Thomas S.

    1996-01-01

    Presents a lesson plan that requires students to use their research and analytical skills in studying the social and economic importance of small business. Activities include interviewing local business owners and producing a written summary, developing a survey showing and explaining area land use, and researching opposition to Wal-Mart stores.…

  9. Revised Accounting for Business Combinations

    ERIC Educational Resources Information Center

    Wilson, Arlette C.; Key, Kimberly

    2008-01-01

    The Financial Accounting Standards Board (FASB) has recently issued Statement of Financial Accounting Standards No. 141 (Revised 2007) Business Combinations. The object of this Statement is to improve the relevance, representational faithfulness, and comparability of reported information about a business combination and its effects. This Statement…

  10. Principles of School Business Management.

    ERIC Educational Resources Information Center

    Wood, R. Craig, Ed.

    This textbook of 24 chapters provides administrators and students with information on the role, activities, and responsibilities of the school business administrator. The independently authored chapters are titled as follows: (1) "Introduction to School Business Management" (F. Mike Miles); (2) "Legal Context of the Public School District" (Paul…

  11. Understanding Business Majors' Learning Styles

    ERIC Educational Resources Information Center

    Giordano, James; Rochford, Regina A.

    2005-01-01

    Recently, business education programs have experienced a decline in enrollment and an increase in attrition. To understand these issues and recommend solutions, the learning styles of 503 first-year business majors at an urban community college were examined. The results demonstrated that: (a) 94% of the participants were analytic learners; (b)…

  12. Introduce XBRL to Business Students

    ERIC Educational Resources Information Center

    Corkern, Sheree M.; Morgan, Mark I.

    2012-01-01

    This paper informs business instructors and educators about XBRL (Extensible Business Reporting Language) so that they can introduce it to their students and expand their students' understanding of how it relates to the accounting profession. Even though the financial community has entered a new age with this standardized reporting language, many…

  13. Business Formulas as Cartesian Curves.

    ERIC Educational Resources Information Center

    Ruppel, Elizabeth

    1982-01-01

    It has been found that students gain much greater insight into routine calculations with business formulas when such work is viewed in the light of graphing concepts. Ten problems are presented that illustrate how three specific objectives in a unit on graphing in a business mathematics course have been met. (MP)

  14. Helping Students Analyze Business Documents.

    ERIC Educational Resources Information Center

    Devet, Bonnie

    2001-01-01

    Notes that student writers gain greater insight into the importance of audience by analyzing business documents. Discusses how business writing teachers can help students understand the rhetorical refinements of writing to an audience. Presents an assignment designed to lead writers systematically through an analysis of two advertisements. (SG)

  15. Business plan writing for physicians.

    PubMed

    Cohn, Kenneth H; Schwartz, Richard W

    2002-08-01

    Physicians are practicing in an era in which they are often expected to write business plans in order to acquire, develop, and implement new technology or programs. This task is yet another reminder of the importance of business principles in providing quality patient care amid allocation of increasingly scarce resources. Unfortunately, few physicians receive training during medical school, residencies, or fellowships in performing such tasks. The process of writing business plans follows an established format similar to writing a consultation, in which the risks, benefits, and alternatives to a treatment option are presented. Although administrative assistance may be available in compiling business plans, it is important for physicians to understand the rationale, process, and pitfalls of business planning. Writing a business plan will serve to focus, clarify, and justify a request for scarce resources, and thus, increase its chance of success, both in terms of funding and implementation. A well-written business plan offers a plausible, coherent story of an uncertain future. Therefore, a business plan is not merely an exercise to obtain funding but also a rationale for investment that can help physicians reestablish leadership in health care.

  16. Small Business Innovations

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Under a Small Business Innovation Research (SBIR) contract to Kennedy Space Center, EIC Laboratories invented a Raman Spectrograph with fiber optic sampling for space applications such as sensing hazardous fuel vapors and making on-board rapid analyses of chemicals and minerals. Raman spectroscopy is a laser-based measurement technique that provides through a unique vibrational spectrum a molecular 'fingerprint,' and can function in aqueous environments. EIC combined optical fiber technology with Raman methods to develop sensors that can be operated at a distance from the spectrographic analysis instruments and the laser excitation source. EIC refined and commercialized the technology to create the Fiber Optic Raman Spectrograph and the RamanProbe. Commercial applications range from process control to monitoring hazardous materials.

  17. Intelsat business service

    NASA Astrophysics Data System (ADS)

    Perras, M.; Sinha, A. K.

    1983-10-01

    Service features and characteristics of Intelsat business services (IBS) are described. The fully digital, near-earth spacecraft interface with ground stations on or near customer facilities. The service is subscribed to on full-, part-time, or occasional use bases, the first two forms by lease. Global coverage in the K- and C-band frequencies is available from the Intelsat satellites, which will include the V-B configuration beginning in 1986. Point-to-point, point-to-multipoint, and full connectivity service is offered on a nonpreemptible basis, with privacy ensured by encryption and quality by a 1/1,000,000 bit error rate. Capacity features 64, 128, and 256 kbps in low-medium data streams and 1.544 and 2.048 Mbps at high rates, with access by quarternary phase shift keying with FDMA techniques. Billing is effected on monthly, hourly, and half-hourly schedules.

  18. Teaching Business Statistics with Real Data to Undergraduates and the Use of Technology in the Class Room

    ERIC Educational Resources Information Center

    Singamsetti, Rao

    2007-01-01

    In this paper an attempt is made to highlight some issues of interpretation of statistical concepts and interpretation of results as taught in undergraduate Business statistics courses. The use of modern technology in the class room is shown to have increased the efficiency and the ease of learning and teaching in statistics. The importance of…

  19. The interventional radiology business plan.

    PubMed

    Beheshti, Michael V; Meek, Mary E; Kaufman, John A

    2012-09-01

    Strategic planning and business planning are processes commonly employed by organizations that exist in competitive environments. Although it is difficult to prove a causal relationship between formal strategic/business planning and positive organizational performance, there is broad agreement that formal strategic and business plans are components of successful organizations. The various elements of strategic plans and business plans are not common in the vernacular of practicing physicians. As health care becomes more competitive, familiarity with these tools may grow in importance. Herein we provide an overview of formal strategic and business planning, and offer a roadmap for an interventional radiology-specific plan that may be useful for organizations confronting competitive and financial threats.

  20. Minding the Business of Business: Tools and Models to Design and Measure Wealth Creation

    ERIC Educational Resources Information Center

    Bernardez, Mariano L.

    2009-01-01

    What is the business of business? How can planners and investors anticipate the true chances of failure and success of a business idea? This article describes a rationale for developing successful new business on the basis of a simple, sensible idea: the business of any business is to make its clients successful enough to continue purchasing and…

  1. 77 FR 30227 - Small Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... BUSINESS ADMINISTRATION 13 CFR Part 121 Small Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR) Program AGENCY: U.S. Small Business... to amend its regulations governing size and eligibility for the Small Business Innovation...

  2. Management of the Business Classroom. National Business Education Association Yearbook, No. 39.

    ERIC Educational Resources Information Center

    Brown, Betty J., Ed.

    This document contains 15 papers devoted to the theme of management of business education. "Management of Business Education: A Perspective" (Betty J. Brown) discusses business education as education about business and education for business. The following papers explore the theme of managing the curriculum: "The Basic Business and Economic…

  3. Interpreting Capability Maturity Model (Trademark) Integration (CMMI (Trademark)) for Business Development Organizations in the Government and Industrial Business Sectors

    DTIC Science & Technology

    2007-01-01

    Sales typically covers a shorter period of time and is tactical. Dr. Philip Kotler , in his text Marketing Management, defines marketing as “a...they hear that the most important part of marketing is not selling! Selling is only the tip of the marketing iceberg” [ Kotler 02]. The focus of this...the enterprise’s success, Kotler writes, “The key to achieving its organizational objectives consists of the [enterprise] being more effective than

  4. Small Group Activities for Introductory Business Classes.

    ERIC Educational Resources Information Center

    Mundrake, George

    1999-01-01

    Describes numerous small-group activities for the following areas of basic business education: consumer credit, marketing, business organization, entrepreneurship, insurance, risk management, economics, personal finance, business careers, global markets, and government regulation. (SK)

  5. Teaching Basic Business: An Entrepreneurial Perspective.

    ERIC Educational Resources Information Center

    Smith, Marsha O.

    2003-01-01

    Suggests that by incorporating entrepreneurship into the basic business curriculum now, business educators will better prepare students for a changing environment. Offers the business plan as a tool for integrating entrepreneurship into the curriculum. (SK)

  6. Pragmatics, "Situated" Language, and Business Communication.

    ERIC Educational Resources Information Center

    Limaye, Mohan; Cherry, Roger

    1987-01-01

    Identifies variables from speech act theory and conversation analysis that might be applied to the study of business communication. Also examines several business letters to see how principles derived from linguistic studies of politeness apply to business communication research. (AEW)

  7. Integrated Business Process Adaptation towards Friction-Free Business-to-Business Collaboration

    ERIC Educational Resources Information Center

    Shan, Zhe

    2011-01-01

    One key issue in process-aware E-commerce collaboration is the orchestration of business processes of multiple business partners throughout a supply chain network in an automated and seamless way. Since each partner has its own internal processes with different control flow structures and message interfaces, the real challenge lies in verifying…

  8. A Business-to-Business Interoperability Testbed: An Overview

    SciTech Connect

    Kulvatunyou, Boonserm; Ivezic, Nenad; Monica, Martin; Jones, Albert

    2003-10-01

    In this paper, we describe a business-to-business (B2B) testbed co-sponsored by the Open Applications Group, Inc. (OAGI) and the National Institute of Standard and Technology (NIST) to advance enterprise e-commerce standards. We describe the business and technical objectives and initial activities within the B2B Testbed. We summarize our initial lessons learned to form the requirements that drive the next generation testbed development. We also give an overview of a promising testing framework architecture in which to drive the testbed developments. We outline the future plans for the testbed development.

  9. Functional csdA is needed for effective adaptation and initiation of growth of Clostridium botulinum ATCC 3502 at suboptimal temperature.

    PubMed

    Söderholm, Henna; Derman, Yağmur; Lindström, Miia; Korkeala, Hannu

    2015-09-02

    The activity of RNA helicase csdA (cbo2802) after temperature downshift was compared to its activity at optimal growth temperature, and the effect of sense and antisense oriented insertional inactivation of cbo2802 on the growth of ATCC 3502 at suboptimal temperature was evaluated. The relative cbo2802 transcript level was significantly induced for 30min to 5h after cold shock. In contrast, a significant decrease in the relative transcript level of cbo2802 was observed within the same time frame at 37°C. Inactivation of cbo2802 led to an extensive delay in initiation of exponential growth at 20°C but not at 37°C. In addition, the mean minimum growth temperatures of the mutant strains were higher than those of the wild-type strain. During a 24-hour incubation at 37°C, all strains were motile, whereas at 20°C the mutant strains showed severely impaired motility compared to the wild-type strain. This study shows that a functional csdA is needed for effective adaptation and initiation of growth and motility of Clostridium botulinum ATCC 3502 at suboptimal temperature.

  10. Food Insecurity, Poor Diet Quality, and Suboptimal Intakes of Folate and Iron Are Independently Associated with Perceived Mental Health in Canadian Adults

    PubMed Central

    Davison, Karen M.; Gondara, Lovedeep; Kaplan, Bonnie J.

    2017-01-01

    Background: To address nutrition-related population mental health data gaps, we examined relationships among food insecurity, diet quality, and perceived mental health. Methods: Stratified and logistic regression analyses of respondents aged 19–70 years from the Canadian Community Health Survey, Cycle 2.2 were conducted (n = 15,546). Measures included the Household Food Security Survey Module, diet quality (i.e., comparisons to the Dietary Reference Intakes, Healthy Eating Index), perceived mental health (poor versus good), sociodemographics, and smoking. Results: In this sample, 6.9% were food insecure and 4.5% reported poor mental health. Stratified analysis of food security and mental health status by age/gender found associations for poor diet quality, protein, fat, fibre, and several micronutrients (p-values < 0.05); those who were food insecure tended to have higher suboptimal intakes (p-values < 0.05). After adjustment for covariates, associations in relation to mental health emerged for food insecurity (OR = 1.60, 95% CI 1.45–1.71), poor diet quality (1.61, 95% CI 1.34–1.81), and suboptimal intakes of folate (OR = 1.58, 95% CI 1.17–1.90) and iron (OR = 1.45, 95% CI 1.23–1.88). Conclusions: Population approaches that improve food security and intakes of high quality diets may protect people from poor mental health. PMID:28335418

  11. Discovery, screening and evaluation of a plasma biomarker panel for subjects with psychological suboptimal health state using 1H-NMR-based metabolomics profiles

    PubMed Central

    Tian, Jun-sheng; Xia, Xiao-tao; Wu, Yan-fei; Zhao, Lei; Xiang, Huan; Du, Guan-hua; Zhang, Xiang; Qin, Xue-mei

    2016-01-01

    Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study aimed to develop an objective method through screen potential biomarkers or a biomarker panel to facilitate the diagnosis in clinic using plasma metabolomics. Profiles were based on H-nuclear magnetic resonance (1H-NMR) metabolomics techniques combing with multivariate statistical analysis. Furthermore, methods of correlation analysis with Metaboanalyst 3.0 for selecting a biomarker panel, traditional Chinese medicine (TCM) drug intervention for validating the close relations between the biomarker panel and the state and the receiver operating characteristic curves (ROC curves) analysis for evaluation of clinical diagnosis ability were carried out. 9 endogenous metabolites containing trimethylamine oxide (TMAO), glutamine, N-acetyl-glycoproteins, citrate, tyrosine, phenylalanine, isoleucine, valine and glucose were identified and considered as potential biomarkers. Then a biomarker panel consisting of phenylalanine, glutamine, tyrosine, citrate, N-acetyl-glycoproteins and TMAO was selected, which exhibited the highest area under the curve (AUC = 0.971). This study provided critical insight into the pathological mechanism of psychological suboptimal health and would supply a novel and valuable diagnostic method. PMID:27650680

  12. Interpretational Confounding or Confounded Interpretations of Causal Indicators?

    PubMed Central

    Bainter, Sierra A.; Bollen, Kenneth A.

    2014-01-01

    In measurement theory causal indicators are controversial and little-understood. Methodological disagreement concerning causal indicators has centered on the question of whether causal indicators are inherently sensitive to interpretational confounding, which occurs when the empirical meaning of a latent construct departs from the meaning intended by a researcher. This article questions the validity of evidence used to claim that causal indicators are inherently susceptible to interpretational confounding. Further, a simulation study demonstrates that causal indicator coefficients are stable across correctly-specified models. Determining the suitability of causal indicators has implications for the way we conceptualize measurement and build and evaluate measurement models. PMID:25530730

  13. Automatic interpretation of digital maps

    NASA Astrophysics Data System (ADS)

    Walter, Volker; Luo, Fen

    In the past, the availability and/or the acquisition of spatial data were often the main problems of the realization of spatial applications. Meanwhile this situation has changed: on one hand, comprehensive spatial datasets already exist and on the other hand, new sensor technologies have the ability to capture fast and with high quality large amounts of spatial data. More and more responsible for the increasing accessibility of spatial data are also collaborative mapping techniques which enable users to create maps by themselves and to make them available in the internet. However, the potential of this diversity of spatial data can only hardly be utilized. Especially maps in the internet are represented very often only with graphical elements and no explicit information about the map's scale, extension and content is available. Nevertheless, humans are able to extract this information and to interpret maps. For example, it is possible for a human to distinguish between rural and industrial areas only by looking at the objects' geometries. Furthermore, a human can easily identify and group map objects that belong together. Also the type, scale and extension of a map can be identified under certain conditions only by looking at the objects' geometries. All these examples can be subsumed under the term "map interpretation". In this paper it is discussed how map interpretation can be automated and how automatic map interpretation can be used in order to support other processes. The different kinds of automatic map interpretation are discussed and two approaches are shown in detail.

  14. 25 CFR 81.16 - Interpreters.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Interpreters. 81.16 Section 81.16 Indians BUREAU OF... STATUTE § 81.16 Interpreters. Interpreters, where needed, may be provided to explain the manner of voting... that the interpreter does not influence the voter in casting the ballot. The interpreter may...

  15. 25 CFR 81.16 - Interpreters.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Interpreters. 81.16 Section 81.16 Indians BUREAU OF INDIAN....16 Interpreters. Interpreters, where needed, may be provided to explain the manner of voting to any... interpreter does not influence the voter in casting the ballot. The interpreter may accompany the voter...

  16. 25 CFR 81.16 - Interpreters.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Interpreters. 81.16 Section 81.16 Indians BUREAU OF... STATUTE § 81.16 Interpreters. Interpreters, where needed, may be provided to explain the manner of voting... that the interpreter does not influence the voter in casting the ballot. The interpreter may...

  17. 25 CFR 81.16 - Interpreters.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Interpreters. 81.16 Section 81.16 Indians BUREAU OF... STATUTE § 81.16 Interpreters. Interpreters, where needed, may be provided to explain the manner of voting... that the interpreter does not influence the voter in casting the ballot. The interpreter may...

  18. 25 CFR 81.16 - Interpreters.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Interpreters. 81.16 Section 81.16 Indians BUREAU OF... STATUTE § 81.16 Interpreters. Interpreters, where needed, may be provided to explain the manner of voting... that the interpreter does not influence the voter in casting the ballot. The interpreter may...

  19. Satellite servicing: A business opportunity?

    NASA Technical Reports Server (NTRS)

    Wong, R. E.; Medler, E. H.

    1984-01-01

    The possibilities of satellite servicing as a business opportunity are examined. The service rate which a user must be charged to yield a reasonable return is derived and then compared against the market's willingness to pay that rate. Steps taken to provide the basis from which the service rate could be derived include: (1) constructing a hypothetical on orbit servicing business offering both on orbit and associated ground services; (2) estimating the total on orbit service business potential by analyzing mission models to the year 2000; and (3) setting up ground rules to bound the conduct of the business. Using this basic information service demand (business volume) cost to set up the business, costs for operation and maintenance tax rates and desired rate of return are estimated to determine the user charge. Sensitivity of the service rate to various parameters are also assessed. The time span for the business venture runs from 1986 through 2000 with service to 1991 provided via the orbiter and by a space station beyond 1991. This point analysis shows about five years of negative cash flow, with steady profits thereafter.

  20. BUSINESS NEEDS AND GRADUATE BUSINESS SCHOOL OFFERINGS IN MARKETING.

    PubMed

    Thams, Meg; Glueck, Deborah

    2007-04-01

    The purpose of this study was to determine if a gap exists in the skill and knowledge businesses require of marketing employees and what the Association to Advance Collegiate Schools of Business (AACSB) accredited schools actually provide. In this quantitative study, two set of data were collected and compared, and a gap analysis conducted. A questionnaire was used to obtain data from members of the Business Marketing Association (BMA) regarding course preferences that would best prepare students for positions in marketing. Records analysis was then undertaken of the marketing course offerings of AACSB accredited MBA programs offering an emphasis in Marketing. Gap analysis was conducted by applying a test of difference to the results of the two data collection efforts. Results of the study suggest that some misalignment between school offerings and business needs exists.