Effect of preinfarction angina pectoris on long-term survival in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention.

PubMed

Taniguchi, Tomohiko; Shiomi, Hiroki; Toyota, Toshiaki; Morimoto, Takeshi; Akao, Masaharu; Nakatsuma, Kenji; Ono, Koh; Makiyama, Takeru; Shizuta, Satoshi; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Horie, Minoru; Kimura, Takeshi

2014-10-15

The influence of preinfarction angina pectoris (AP) on long-term clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI) remains controversial. In 5,429 patients with acute myocardial infarction (AMI) enrolled in the Coronary Revascularization Demonstrating Outcome Study in Kyoto AMI Registry, the present study population consisted of 3,476 patients with STEMI who underwent primary PCI within 24 hours of symptom onset and in whom the data on preinfarction AP were available. Preinfarction AP defined as AP occurring within 48 hours of hospital arrival was present in 675 patients (19.4%). Patients with preinfarction AP was younger and more often had anterior AMI and longer total ischemic time, whereas they less often had history of heart failure, atrial fibrillation, and shock presentation. The infarct size estimated by peak creatinine phosphokinase was significantly smaller in patients with than in patients without preinfarction AP (median [interquartile range] 2,141 [965 to 3,867] IU/L vs 2,462 [1,257 to 4,495] IU/L, p <0.001). The cumulative 5-year incidence of death was significantly lower in patients with preinfarction AP (12.4% vs 20.7%, p <0.001) with median follow-up interval of 1,845 days. After adjusting for confounders, preinfarction AP was independently associated with a lower risk for death (hazard ratio 0.69, 95% confidence interval 0.54 to 0.86, p = 0.001). The lower risk for 5-year mortality in patients with preinfarction AP was consistently observed across subgroups stratified by total ischemic time, initial Thrombolysis In Myocardial Infarction flow grade, hemodynamic status, infarct location, and diabetes mellitus. In conclusion, preinfarction AP was independently associated with lower 5-year mortality in patients with STEMI who underwent primary PCI. Copyright © 2014 Elsevier Inc. All rights reserved.

Periodic variation in the geomagnetic activity - A study based on the Ap index

NASA Technical Reports Server (NTRS)

De Gonzalez, Alicia L. C.; Gonzalez, Walter D.; Dutra, Severino L. G.; Tsurutani, Bruce T.

1993-01-01

The monthly and daily samples of the Ap index for the interval from 1932 through 1982 were studied using the power spectrum technique. Results obtained for Bartel's period (about 27 days), the semiannual period, the dual-peak solar cycle distribution of geomagnetic storms, and certain other medium-scale periodicities are examined in detail. In addition, results on the cumulative occurrence number of storms per decade as a function of the Ap and Dst indices for the storm are presented.

ParamAP: Standardized Parameterization of Sinoatrial Node Myocyte Action Potentials.

PubMed

Rickert, Christian; Proenza, Catherine

2017-08-22

Sinoatrial node myocytes act as cardiac pacemaker cells by generating spontaneous action potentials (APs). Much information is encoded in sinoatrial AP waveforms, but both the analysis and the comparison of AP parameters between studies is hindered by the lack of standardized parameter definitions and the absence of automated analysis tools. Here we introduce ParamAP, a standalone cross-platform computational tool that uses a template-free detection algorithm to automatically identify and parameterize APs from text input files. ParamAP employs a graphic user interface with automatic and user-customizable input modes, and it outputs data files in text and PDF formats. ParamAP returns a total of 16 AP waveform parameters including time intervals such as the AP duration, membrane potentials such as the maximum diastolic potential, and rates of change of the membrane potential such as the diastolic depolarization rate. ParamAP provides a robust AP detection algorithm in combination with a standardized AP parameter analysis over a wide range of AP waveforms and firing rates, owing in part to the use of an iterative algorithm for the determination of the threshold potential and the diastolic depolarization rate that is independent of the maximum upstroke velocity, a parameter that can vary significantly among sinoatrial APs. Because ParamAP is implemented in Python 3, it is also highly customizable and extensible. In conclusion, ParamAP is a powerful computational tool that facilitates quantitative analysis and enables comparison of sinoatrial APs by standardizing parameter definitions and providing an automated work flow. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Effect of baroreceptor denervation on the autonomic control of arterial pressure in conscious mice.

PubMed

Rodrigues, Fernanda Luciano; de Oliveira, Mauro; Salgado, Helio Cesar; Fazan, Rubens

2011-09-01

This study evaluated the role of arterial baroreceptors in arterial pressure (AP) and pulse interval (PI) regulation in conscious C57BL mice. Male animals, implanted with catheters in a femoral artery and a jugular vein, were submitted to sino-aortic (SAD), aortic (Ao-X) or carotid sinus denervation (Ca-X), 5 days prior to the experiments. After basal recording of AP, the lack of reflex bradycardia elicited by administration of phenylephrine was used to confirm the efficacy of SAD, and cardiac autonomic blockade with methylatropine and propranolol was performed. The AP and PI variability were calculated in the time and frequency domains (spectral analysis/fast Fourier transform) with the spectra quantified in low- (LF; 0.25-1 Hz) and high-frequency bands (HF; 1-5 Hz). Basal AP and AP variability were higher after SAD, Ao-X or Ca-X than in intact mice. Pulse interval was similar among the groups, whereas PI variability was lower after SAD. Atropine elicited a slight tachycardia in control mice but did not change PI after total or partial denervation. The bradycardia caused by propranolol was higher after SAD, Ao-X or Ca-X compared with intact mice. The increase in the variability of AP was accompanied by a marked increase in the LF and HF power of the AP spectra after baroreceptor denervation. The LF and HF power of the PI were reduced by SAD and by Ao-X or Ca-X. Therefore, both sino-aortic and partial baroreceptor denervation in mice elicits hypertension and a remarkable increase in AP variability and cardiac sympathetic tonus. Spectral analysis showed an important contribution of the baroreflex in the power of LF oscillations of the PI spectra. Both sets of baroreceptors seem to be equally important in the autonomic regulation of the cardiovascular system in mice.

Polymorphism within thyroid hormone responsive (THRSP) associated with weaning-to-oestrus interval in swine

USDA-ARS?s Scientific Manuscript database

The objective of this study was to assess polymorphisms within lipogenic-related candidate genes for association with the reproductive traits; age at puberty (AP), ovulation rate (OR), and weaning-to-estrus interval (WEI). Variations within the anorectic gene Cocaine- and Amphetamine-Regulated Trans...

PREFACE: Second Meeting of the APS Topical Group on Hadronic Physics

NASA Astrophysics Data System (ADS)

Ernst, David; de Jager, Kees; Roberts, Craig; Sheldon, Paul; Swanson, Eric

2007-06-01

The Second Meeting of the APS Topical Group on Hadronic Physics was held on 22-24 October 2006 at the Opryland Resort in Nashville, Tennessee. Keeping with tradition, the meeting was held in conjunction with the Fall meeting of the APS Division of Nuclear Physics. Approximately 90 physicists participated in the meeting, presenting 25 talks in seven plenary sessions and 48 talks in 11 parallel sessions. These sessions covered a wide range of topics related to strongly interacting matter. Among these were charm spectroscopy, gluonic exotics, nucleon resonance physics, RHIC physics, electroweak and spin physics, lattice QCD initiatives, and new facilities. Brad Tippens and Brad Keister provided perspective from the funding agencies. The organisers are extremely grateful to the following institutions for financial and logistical support: the American Physical Society, Jefferson Lab, Brookhaven National Laboratory, and Vanderbilt University. We thank the following persons for assisting in organising the parallel sessions: Ted Barnes, Jian-Ping Chen, Ed Kinney, Krishna Kumar, Harry Lee, Mike Leitch, Kam Seth, and Dennis Weygand. We also thank Gerald Ragghianti for designing the conference poster, Will Johns for managing the audio-visual equipment and for placing the talks on the web, Sandy Childress for administrative expertise, and Vanderbilt graduate students Eduardo Luiggi and Jesus Escamillad for their assistance. David Ernst, Kees de Jager, Craig Roberts (Chair), Paul Sheldon and Eric Swanson Editors

Conference Committees: Conference Committees

NASA Astrophysics Data System (ADS)

2009-09-01

International Programm Committee (IPC) Harald Ade NCSU Sadao Aoki University Tsukuba David Attwood Lawrence Berkeley National Laboratory/CXRO Christian David Paul Scherrer Institut Peter Fischer Lawrence Berkeley National Laboratory Adam Hitchcock McMaster University Chris Jacobsen SUNY, Stony Brook Denis Joyeux Lab Charles Fabry de l'Institut d'Optique Yasushi Kagoshima University of Hyogo Hiroshi Kihara Kansai Medical University Janos Kirz SUNY Stony Brook Maya Kiskinova ELETTRA Ian McNulty Argonne National Lab/APS Alan Michette Kings College London Graeme Morrison Kings College London Keith Nugent University of Melbourne Zhu Peiping BSRF Institute of High Energy Physics Francois Polack Soleil Christoph Quitmann Paul Scherrer Institut Günther Schmahl University Göttingen Gerd Schneider Bessy Hyun-Joon Shin Pohang Accelerator Lab Jean Susini ESRF Mau-Tsu Tang NSRRC Tony Warwick Lawrence Berkeley Lab/ALS Local Organizing Committee Christoph Quitmann Chair, Scientific Program Charlotte Heer Secretary Christian David Scientific Program Frithjof Nolting Scientific Program Franz Pfeiffer Scientific Program Marco Stampanoni Scientific Program Robert Rudolph Sponsoring, Financials Alfred Waser Industry Exhibition Robert Keller Public Relation Markus Knecht Computing and WWW Annick Cavedon Proceedings and Excursions and Accompanying Persons Program Margrit Eichler Excursions and Accompanying Persons Program Kathy Eikenberry Excursions and Accompanying Persons Program Marlies Locher Excursions and Accompanying Persons Program

Erratum: The Extragalactic Distance Scale Key Project. III. The Discovery of Cepheids and a New Distance to M101 Using the Hubble Space Telescope

NASA Astrophysics Data System (ADS)

Kelson, Daniel D; Illingworth, Garth D.; Freedman, Wendy F.; Graham, John A.; Hill, Robert; Madore, Barry F.; Saha, Abhijit; Stetson, Peter B.; Kennicutt, Robert C., Jr.; Mould, Jeremy R.; Hughes, Shaun M.; Ferrarese, Laura; Phelps, Randy; Turner, Anne; Cook, Kem H.; Ford, Holland; Hoessel, John G.; Huchra, John

1997-03-01

In the paper ``The Extragalactic Distance Scale Key Project. III. The Discovery of Cepheids and a New Distance to M101 Using the Hubble Space Telescope'' by Daniel D. Kelson, Garth D. Illingworth, Wendy F. Freedman, John A. Graham, Robert Hill, Barry F. Madore, Abhijit Saha, Peter B. Stetson, Robert C. Kennicutt, Jr., Jeremy R. Mould, Shaun M. Hughes, Laura Ferrarese, Randy Phelps, Anne Turner, Kem H. Cook, Holland Ford, John G. Hoessel, and John Huchra (ApJ, 463, 26 [1996]), two of the tables are in error. The magnitudes in Tables B1 and B2, in Appendix B, are ordered incorrectly. As a result, the Julian dates are not associated with their correct Cepheid magnitudes. We have now corrected these data, and updated versions of the tables are available on the World Wide Web. The tables are available in ASCII format at our Key Project site (http://www.ipac.caltech.edu/H0kp/) and will appear in volume 7 of the AAS CDROM. PostScript and paper copies are also available from the first author (http://www.ucolick.org/~kelson/H0/home.html or kelson@ucolick.org).

Electrophysiologic profile and results of invasive risk stratification in asymptomatic children and adolescents with the Wolff-Parkinson-White electrocardiographic pattern.

PubMed

Kubuš, Peter; Vít, Pavel; Gebauer, Roman A; Materna, Ondřej; Janoušek, Jan

2014-04-01

Data on the results and clinical effect of an invasive risk stratification strategy in asymptomatic young patients with the Wolff-Parkinson-White electrocardiographic pattern are scarce. Eighty-five consecutive patients aged<18 years with a Wolff-Parkinson-White pattern and persistent preexcitation at maximum exercise undergoing invasive risk stratification were retrospectively studied. Adverse accessory pathway (AP) properties were defined according to currently consented criteria as any of the following: shortest preexcited RR interval during atrial fibrillation/rapid atrial pacing≤250 ms (or antegrade effective refractory period≤250 ms if shortest preexcited RR interval was not available) or inducible atrioventricular re-entrant tachycardia. Age at evaluation was median 14.9 years. Eighty-two patients had a structurally normal heart and 3 had hypertrophic cardiomyopathy. A single manifest AP was present in 80, 1 manifest and 1 concealed AP in 4, and 2 manifest APs in 1 patient. Adverse AP properties were present in 32 of 85 patients (37.6%) at baseline and in additional 16 of 44 (36.4%) after isoproterenol. Ablation was performed in 41 of these 48 patients. Ablation was deferred in the remaining 7 for pathway proximity to the atrioventricular node. In addition, 18 of the low-risk patients were ablated based on patient/parental decision. Adverse AP properties at baseline were exhibited by 37.6% of the evaluated patients with an asymptomatic Wolff-Parkinson-White preexcitation persisting at peak exercise. Isoproterenol challenge yielded additional 36.4% of those tested at higher risk. Ablation was performed in a total of 69.4% of patients subjected to invasive risk stratification.

Heavy Smoking Is Associated With Lower Age at First Episode of Acute Pancreatitis and a Higher Risk of Recurrence.

PubMed

Munigala, Satish; Conwell, Darwin L; Gelrud, Andres; Agarwal, Banke

2015-08-01

There is limited data on cigarette smoking and the risk of acute pancreatitis (AP). We evaluated the influence of cigarette smoking on AP risk and clinical presentation in a large cohort of Veteran's Administration (VA) patients. Retrospective study of VA patients from 1998 to 2007. Exclusion criteria included (1) history of chronic pancreatitis (n = 3222) or gallstones (n = 14,574) and (2) age younger than 15 years (n = 270). A 2-year washout period was used to exclude patients with pre-existing recurrent AP. The study included 484,624 patients. From 2001 to 2007, a total of 6799 (1.4%) patients had AP. Alcohol (risk ratio, 4.20) and smoking (risk ratio, 1.78) were independent significant risk factors of AP on multiple regression analysis. Smoking increased the risk of AP in both nonalcoholics (0.57% vs 1.1%) and alcoholics (2.6% vs 4.1%). Smoking was associated with younger mean age at first episode of AP and higher likelihood of recurrent AP (≥4 episodes) in both nonalcoholics and alcoholics. The interval between recurrent episodes was not altered by alcohol or smoking. In a large cohort of VA patients, smoking is an independent risk factor for AP and augmented the effect of alcohol on the risk, age of onset, and recurrence of AP.

Risk factors for pancreatitis in older women: the Iowa Women's Health Study.

PubMed

Prizment, Anna E; Jensen, Eric H; Hopper, Anne M; Virnig, Beth A; Anderson, Kristin E

2015-07-01

Pancreatitis-an inflammation of pancreas-is a severe and costly disease. Although many risk factors for pancreatitis are known, many pancreatitis cases, especially in elderly women, are of unknown etiology. Risk factors for acute pancreatitis (AP) and chronic pancreatitis (CP) were assessed in a prospective cohort (n = 36,436 women, aged ≥ 65 years). Exposures were self-reported at baseline. Pancreatitis was ascertained by linkage to Medicare claims (1986-2004) categorized by a physician as follows: "AP", one AP episode (n = 511) or "CP", 2+ AP or 1+ CP episodes (n = 149). Multivariable odds ratios (ORs) and 95% confidence intervals for AP and CP were calculated using multinomial logistic regression. Alcohol use was not associated with AP or CP. Heavy smoking (40+ vs. 0 pack-years) was associated with a twofold increased OR for CP. For body mass index greater than or equal to 30 versus less than 25 kg/m(2), the ORs were 1.35 (1.07-1.70) for AP (P trend = .009) and 0.59 (0.37-0.94) for CP (P trend = .01). ORs for AP and CP were increased for hormone replacement therapy use, heart disease, and hypertension. There were positive significant associations between protein and total fat intake for CP and AP. We identified factors associated with AP and CP that may be specific to older women. Copyright © 2015 Elsevier Inc. All rights reserved.

Heart rate variability in the individual fetus.

PubMed

Van Leeuwen, Peter; Cysarz, Dirk; Edelhäuser, Friedrich; Grönemeyer, Dietrich

2013-11-01

The change in fetal heart rate and its variability (HRV) during the course of gestation has been documented by numerous studies. The overall drop in heart rate and increase in fetal HRV is associated with fetal growth in general and with the increase in neural integration in particular. The increased complexity of the demands on the cardiovascular system leads to more variation in the temporal course of the heart rate. Most studies that document and interpret these changes are based on data acquired in groups of fetuses. The aim of this work was to investigate HRV within single fetuses. We acquired 213 5min fetal magnetocardiograms in 11 fetuses during the second and third trimesters (at least 10 data sets per fetus, median 17). From the magnetocardiograms we determined the fetal RR interval time series and calculated the standard deviation (SDNN), root mean square of successive differences (RMSSD), approximate entropy (ApEn) and temporal asymmetry (Irrev). For each subject and HRV measure, we performed regression analysis with respect to gestational age, alone and in combination with RR interval. The coefficient of determination R(2) was used to estimate goodness-of-fit. The coefficient of quartile dispersion (CQD) was used to compare the regression parameters for each HRV measure. Overall, the HRV measures increased with age and RR interval. The consistency of the HRV measures within the individual fetuses was greater than in the data pooled over all fetuses. The individual R(2) for the model including age and RR interval was best for ApEn (.79, .59-.94; median, 90% CI), followed by RMSSD (.71, .25-.88), SDNN (.55, .18-.90) and Irrev (.16, .01-.39). These values, except for Irrev, were higher than those calculated over all 213 data sets (R(2)=.65, .63, .35, .28, respectively). The slopes of the regressions of each individual's data were most consistent over all subjects for ApEn, followed by RMSSD and SDNN and Irrev. Interindividually, the time domain measures showed discrepancies and the within-fetus courses were more consistent than the course over all fetuses. On the other hand, the course of ApEn during gestation was not only very consistent within each fetus but also very similar between most of subjects. Complexity measures such as ApEn may thus more consistently reflect prenatal developmental factors influencing cardiovascular regulation. Copyright © 2013 Elsevier B.V. All rights reserved.

Thrombosis-related complications and mortality in cancer patients with central venous devices: an observational study on the effect of antithrombotic prophylaxis.

PubMed

Fagnani, D; Franchi, R; Porta, C; Pugliese, P; Borgonovo, K; Bertolini, A; Duro, M; Ardizzoia, A; Filipazzi, V; Isa, L; Vergani, C; Milani, M; Cimminiello, C

2007-03-01

Recent guidelines do not recommend antithrombotic prophylaxis (AP) to prevent catheter-related thrombosis in cancer patients with a central line. This study assessed the management of central lines in cancer patients, current attitude towards AP, catheter-related and systemic venous thromboses, and survival. Of 1410 patients enrolled, 1390 were seen at least once in the 6-month median follow-up. Continuous AP, mainly low-dose warfarin, was given to 451 (32.4%); they were older, with a more frequent history of venous thromboembolism (VTE), and more advanced cancer. There was no difference in catheter-related thrombosis in patients given AP or not (2.8% and 2.2%, odds ratio 1.29, 95% confidence interval 0.64-2.6). The median time to first catheter-related complication was 120 days. Systemic VTE including deep and superficial thromboses and pulmonary embolism, were less frequent with AP (4% versus 8.2%, P = 0.005). Mortality was also lower (25% versus 44%, P = 0.0001). Multiple logistic regression analysis found only advanced cancer and no AP significantly associated with mortality. No major bleeding was recorded with AP. Current AP schedules do not appear to prevent catheter-related thrombosis. Systemic VTE and mortality, however, appeared lower after prophylaxis.

Quantitative comparison of entropy analysis of fetal heart rate variability related to the different stages of labor.

PubMed

Lim, Jongil; Kwon, Ji Young; Song, Juhee; Choi, Hosoon; Shin, Jong Chul; Park, In Yang

2014-02-01

The interpretation of the fetal heart rate (FHR) signal considering labor progression may improve perinatal morbidity and mortality. However, there have been few studies that evaluate the fetus in each labor stage quantitatively. To evaluate whether the entropy indices of FHR are different according to labor progression. A retrospective comparative study of FHR recordings in three groups: 280 recordings in the second stage of labor before vaginal delivery, 31 recordings in the first stage of labor before emergency cesarean delivery, and 23 recordings in the pre-labor before elective cesarean delivery. The stored FHR recordings of external cardiotocography during labor. Approximate entropy (ApEn) and sample entropy (SampEn) for the final 2000 RR intervals. The median ApEn and SampEn for the 2000 RR intervals showed the lowest values in the second stage of labor, followed by the emergency cesarean group and the elective cesarean group for all time segments (all P<0.001). Also, in the second stage of labor, the final 5 min of 2000 RR intervals had a significantly lower median ApEn (0.49 vs. 0.44, P=0.001) and lower median SampEn (0.34 vs. 0.29, P<0.001) than the initial 5 min of 2000 RR intervals. Entropy indices of FHR were significantly different according to labor progression. This result supports the necessity of considering labor progression when developing intrapartum fetal monitoring using the entropy indices of FHR. Copyright © 2013 Elsevier Ltd. All rights reserved.

Cardiac action potential repolarization revisited: early repolarization shows all-or-none behaviour.

PubMed

Trenor, Beatriz; Cardona, Karen; Saiz, Javier; Noble, Denis; Giles, Wayne

2017-11-01

In healthy mammalian hearts the action potential (AP) waveform initiates and modulates each contraction, or heartbeat. As a result, AP height and duration are key physiological variables. In addition, rate-dependent changes in ventricular AP duration (APD), and variations in APD at a fixed heart rate are both reliable biomarkers of electrophysiological stability. Present guidelines for the likelihood that candidate drugs will increase arrhythmias rely on small changes in APD and Q-T intervals as criteria for safety pharmacology decisions. However, both of these measurements correspond to the final repolarization of the AP. Emerging clinical evidence draws attention to the early repolarization phase of the action potential (and the J-wave of the ECG) as an additional important biomarker for arrhythmogenesis. Here we provide a mechanistic background to this early repolarization syndrome by summarizing the evidence that both the initial depolarization and repolarization phases of the cardiac action potential can exhibit distinct time- and voltage-dependent thresholds, and also demonstrating that both can show regenerative all-or-none behaviour. An important consequence of this is that not all of the dynamics of action potential repolarization in human ventricle can be captured by data from single myocytes when these results are expressed as 'repolarization reserve'. For example, the complex pattern of cell-to-cell current flow that is responsible for AP conduction (propagation) within the mammalian myocardium can change APD and the Q-T interval of the electrocardiogram alter APD stability, and modulate responsiveness to pharmacological agents (such as Class III anti-arrhythmic drugs). © 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society.

Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome.

PubMed

Tanaka, Yasutaka; Ueno, Yuji; Miyamoto, Nobukazu; Shimada, Yoshiaki; Tanaka, Ryota; Hattori, Nobutaka; Urabe, Takao

2013-01-01

The purpose of the present study was to evaluate the contributions of embolic etiologies, patent foramen ovale (PFO) and atrial septal aneurysm (ASA) to the pathogenesis of ischemic stroke in patients with antiphospholipid syndrome (APS). We performed transesophageal echocardiography (TEE) examination for consecutive stroke patients who had been diagnosed with APS (APS group) to detect potential embolic sources. APS was diagnosed based on the modified Sapporo criteria. The control stroke group comprised age- and sex-matched cryptogenic stroke patients undergoing TEE. We assessed and compared the clinical characteristics and TEE findings between stroke patients with APS and control stroke groups. Among 582 patients, nine patients (nine women; mean age, 50 ± 18 years) were classified into the APS group. In 137 patients undergoing TEE, 41 age-matched female stroke patients were recruited to the control stroke group. Prevalences of PFO and ASA were significantly higher in the APS group than in the control stroke group (89 vs. 41 %, p = 0.027; 67 vs. 20 %, p = 0.015, respectively). Multiple logistic regression analysis showed that PFO (odds ratio (OR), 13.71; 95 % confidence interval (CI), 1.01-185.62; p = 0.049) and ASA (OR, 8.06; 95 % CI, 1.17-55.59; p = 0.034) were independently associated with the APS group. PFO and ASA were strongly associated with the APS group, and could thus represent potential embolic sources in ischemic stroke patients with APS.

Cerebral infarction in the left hemisphere compared with the right hemisphere increases the risk of aspiration pneumonia.

PubMed

Yamamoto, Keiichi; Koh, Hideo; Shimada, Hiroyuki; Takeuchi, Jun; Yamakawa, Yoshihiro; Kawamura, Mayumi; Miki, Takami

2014-12-01

Aspiration pneumonia (AP) following cerebral infarction (CI) has been considered as one of its most serious complications. Nevertheless, there are no reports on the association between the type or location of CI and the incidence of AP. In addition, the association between dysphagia, which leads to aspiration, and the type or location of CI has never been investigated. Therefore we hypothesized that the laterality of CI affects the development of both dysphagia and AP. We performed a retrospective cohort study to examine the association between the laterality of CI and the incidence of dysphagia and AP in 133 patients. AP was found in 6.0% of the group with left CI and in 0.8% of the group with right CI. A univariate logistic regression analysis revealed that left CI was a significant predictor of AP (hazard ratio, 8.81; 95% confidence interval, 1.07-72.59; p = 0.043). Left CI was a significant predictor of AP even after adjusting for age, sex, CI type, or presence of diabetes mellitus. In addition, although the frequency of dysphagia as the direct cause of AP did not differ according to laterality, the frequency of AP that ensued from dysphagia in the left CI group was greater than that observed in the right CI group. The group with left CI from the motor cortex to the internal capsule complicated by dysphagia exhibited a high risk of AP.

The effects of roflumilast on the pancreas and remote organs in a cerulein-induced experimental acute pancreatitis model in rats.

PubMed

Uslukaya, Omer; Turkoglu, Ahmet; Yazgan, Umit Can; Kaplan, Ibrahim; Ibiloglu, Ibrahim; Kapan, Murat; Gumus, Metehan

2016-12-01

Systemic damage in acute pancreatitis (AP) can be characterized by oxidative stress and the release of pro-inflammatory cytokines. Roflumilast has been shown to be a potent anti-inflammatory and antioxidant agent. In the present study, we aimed to investigate the effect of roflumilast in cerulein-induced AP. Thirty-two male rats were divided into four groups: group 1 (sham), group 2 (Roflumilast), group 3 (AP), and group 4 (AP + Roflumilast). AP was induced by injecting 4 × 75 μg/kg of body weight at an interval of 1 h. Rats were killed after 12 h following the last cerulein administration. AP was confirmed by measuring the serum amylase level and inflammatory features. Morphological changes were observed in the pancreas. Amylase levels were higher in the AP and AP + Roflumilast groups than the sham and Roflumilast groups. The serum levels of TNF-α, IL-1β, and IL-6 increased in the AP group, whereas they decreased in the Roflumilast group. The total oxidant activity (TOA) was higher and the total antioxidant capacity (TAC) was lower in the AP group. The administration of roflumilast decreased the TOA and increased the TAC in comparison with the AP group (p < 0.05 for both). Roflumilast significantly decreases oxidative stress and inflammatory mediators in the plasma, pancreas, and lung in cerulein-induced AP rats.

Phase correlated adequate afferent action potentials as a drive of human spinal oscillators.

PubMed

Schalow, G

1993-12-01

1. By recording, with 2 pairs of wire electrodes, single-fibre action potentials (APs) from lower sacral nerve roots of a brain-dead human and a patient with spinal cord lesion, impulse patterns of afferent APs and impulse trains of oscillatory firing motoneurons could be identified and correlated. 2. Two highly activated secondary muscle spindle afferents increased and decreased their activity at about 0.3 Hz. The duration of the doublet interspike interval of a secondary spindle afferent fibre showed no correlation to the oscillation period of the motoneuron. 3. A continuously oscillatory firing motoneuron innervating the external and sphincter showed more transient breaks with the reduction of the number of phase correlated APs from 2 spindle afferents, indicating a looser oscillation. A transient brake of a 157 msec period alpha 2-oscillation could be correlated to the shift of a interspike interval distribution peak from 150 to 180 msec of the adequate afferent input, which suggests a transient loss of the necessary phase relation. 4. Oscillatory firing alpha 2-motoneurons innervating the external bladder and anal sphincters fired independently according to their phase correlated APs from the urinary bladder stretch receptor and muscle spindle afferents respectively; the bladder motoneuron slightly inhibited the anal motoneuron. 5. Receptors of the afferents and innervation sites of oscillatory firing motoneurons could be located within the urinary tract and the anal canal.

Looking Back and Ahead: 20 Years of Technologies for Language Learning

ERIC Educational Resources Information Center

Godwin-Jones, Robert

2016-01-01

Over the last 20 years Robert Godwin-Jones has written 48 columns on "Emerging Technologies"; an additional six columns have been written by guest columnists. Several topics have been re-examined in regular intervals of approximately five years, namely digital literacy (Vol. 4, Num. 2; Vol. 10, Num. 2; Vol. 14, Num. 3; Vol. 19, Num. 3)…

Auditory Pattern Memory

DTIC Science & Technology

1989-10-31

Psychology Building 410 Gainsvile, L 3611Boi ing AFB, DC 20332-6448 Ia. NAME OF FUNDING/SPONSORING &.OFF ICE SYMBOL 9. PROCUREMENT INSTRUMENT...Observers Robert D. Sorkin Department of Psychology University of Florida Gainesville, Florida 32611 31 October 1989 Annual Technical Report for Period 1...employing single, marked time intervals ( Creelman , 1962; Getty, 1975; Divenyi and Danner, 1977; Divenyi and Sachs, 1978; and Allen, 1979). Sorkin et

Anteroposterior translation does not correlate with knee flexion after total knee arthroplasty.

PubMed

Ishii, Yoshinori; Noguchi, Hideo; Takeda, Mitsuhiro; Sato, Junko; Toyabe, Shin-ichi

2014-02-01

Stiffness after a TKA can cause patient dissatisfaction and diminished function, therefore it is important to characterize predictors of ROM after TKA. Studies of AP translation in conscious individuals disagree whether AP translation affects maximum knee flexion angle after implantation of a highly congruent sphere and trough geometry PCL-substituting prosthesis in a TKA. We investigated whether AP translation correlated with maximum knee flexion angle (1) in patients who were awake, and (2) who were under anesthesia (to minimize the effects of voluntary muscle contraction) in a TKA with implantation of a PCL-substituting mobile-bearing prosthesis. AP translation was examined under both conditions in 34 primary TKAs. Measurements under anesthesia were performed when the patients were having anesthesia for a contralateral TKA. Awake measurements were made within 4 days of that anesthetic session in patients who had no residual sedative effects. The average postoperative interval for the index TKA flexion measurements was 23 months (range, 6-114 months). AP translation was evaluated at 75° flexion using an arthrometer. There was no correlation between postoperative maximum knee flexion and AP translation at 75° during consciousness. There was no correlation between postoperative maximum knee flexion and AP translation under anesthesia. AP translation at 75° flexion did not correlate with postoperative maximum knee flexion in either awake or anesthetized patients during a TKA with implantation of a posterior cruciate-substituting prosthesis.

Recovery of the vomiting reflex following area postrema ablation in squirrel monkeys

NASA Technical Reports Server (NTRS)

Elfar, S.; Brizzee, Kenneth R.; Fox, Robert A.; Corcoran, Meryl Lee; Daunton, Nancy G.; Coleman, J.

1991-01-01

The role of the area postrema (AP) in motion-induced emesis was re-assessed recently in several different species. In a few of these studies, the role of the AP in motion-induced conditioned taste aversion (CTA) was also addressed. The purpose was to extend this comparative study to the squirrel monkey, to evaluate further the role of AP in vomiting, and to investigate the dynamics of the recovery process. The AP was ablated bilaterally in 7 motion-susceptible squirrel monkeys which previously had been characterized in terms of their responses to various motion sickness-inducing stimuli. After recovery from surgery all animals were tested at 30-day intervals for a period of 11 months to determine the effects of AP ablations on susceptibility to the same sickness-inducing conditions. In addition, the effectiveness of motion in preducing CTA was evaluated. All pre-ablation motion tests involved stimulation for 30 min., while post-lesion tests were 60 min., in duration. All animals showed significant increases in latencies to vomiting after AP ablations. However, the latencies tended to decrease with time after ablation. All but one animal vomited on at least one of the 10 motion tests occurring after ablation of AP. In addition, CTA was produced by motion used in the conditioning sessions. These results suggest that structures other than AP, and processes other that those mediated through AP, may play an important role in motion-induced emesis.

Comparison of Clinical Characteristics and Outcomes of Patients With Versus Without Diabetes Mellitus and With Versus Without Angina Pectoris (from the Duke Databank for Cardiovascular Disease).

PubMed

Banks, Adam; Broderick, Samuel; Chiswell, Karen; Shaw, Linda; Devore, Adam; Fiuzat, Mona; O'Connor, Christopher; Felker, Gary Michael; Velazquez, Eric; Mentz, Robert

2017-06-01

Angina pectoris (AP) has different prognostic implications in various populations. Patients with diabetes mellitus (DM) may experience neuropathy such that AP may not be perceived in the setting of coronary artery disease (CAD). The prognostic utility of AP in DM patients with CAD is not well known. We analyzed patients with CAD who underwent coronary angiography at Duke University from 2002 to 2011 and compared patients with and without AP within the previous 6 weeks stratified by DM status. We used multivariable Cox regression to assess the association between AP and the outcomes of cardiovascular (CV) hospitalization/revascularization, all-cause mortality/myocardial infarction/revascularization, and all-cause mortality. Of 17,211 patients with CAD, 5,284 (31%) had DM and AP was present in 69% of DM and 67% of non-DM. After risk adjustment, the risk of CV hospitalization/revascularization and all-cause mortality/myocardial infarction/revascularization in patients with and without AP was similar regardless of DM status (all p ≥0.05). In patients with or without DM, AP was associated with lower all-cause mortality compared with no AP (adjusted hazard ratio 0.89, 95% confidence interval 0.82 to 0.97, p = 0.005 for DM patients). The relation between AP status and clinical outcomes was not dependent on DM status (all interaction p >0.10). In conclusion, in patients with CAD, AP was associated with similar risk for CV hospitalization and revascularization and lower all-cause mortality compared with patients without AP regardless of DM status. Future studies are needed to assess whether these findings are related to increased severity of disease in those without AP or whether AP leads to differential management that improves survival. Copyright © 2017 Elsevier Inc. All rights reserved.

Cardiac interbeat interval dynamics from childhood to senescence : comparison of conventional and new measures based on fractals and chaos theory

NASA Technical Reports Server (NTRS)

Pikkujamsa, S. M.; Makikallio, T. H.; Sourander, L. B.; Raiha, I. J.; Puukka, P.; Skytta, J.; Peng, C. K.; Goldberger, A. L.; Huikuri, H. V.

1999-01-01

BACKGROUND: New methods of R-R interval variability based on fractal scaling and nonlinear dynamics ("chaos theory") may give new insights into heart rate dynamics. The aims of this study were to (1) systematically characterize and quantify the effects of aging from early childhood to advanced age on 24-hour heart rate dynamics in healthy subjects; (2) compare age-related changes in conventional time- and frequency-domain measures with changes in newly derived measures based on fractal scaling and complexity (chaos) theory; and (3) further test the hypothesis that there is loss of complexity and altered fractal scaling of heart rate dynamics with advanced age. METHODS AND RESULTS: The relationship between age and cardiac interbeat (R-R) interval dynamics from childhood to senescence was studied in 114 healthy subjects (age range, 1 to 82 years) by measurement of the slope, beta, of the power-law regression line (log power-log frequency) of R-R interval variability (10(-4) to 10(-2) Hz), approximate entropy (ApEn), short-term (alpha(1)) and intermediate-term (alpha(2)) fractal scaling exponents obtained by detrended fluctuation analysis, and traditional time- and frequency-domain measures from 24-hour ECG recordings. Compared with young adults (<40 years old, n=29), children (<15 years old, n=27) showed similar complexity (ApEn) and fractal correlation properties (alpha(1), alpha(2), beta) of R-R interval dynamics despite lower spectral and time-domain measures. Progressive loss of complexity (decreased ApEn, r=-0.69, P<0.001) and alterations of long-term fractal-like heart rate behavior (increased alpha(2), r=0.63, decreased beta, r=-0.60, P<0.001 for both) were observed thereafter from middle age (40 to 60 years, n=29) to old age (>60 years, n=29). CONCLUSIONS: Cardiac interbeat interval dynamics change markedly from childhood to old age in healthy subjects. Children show complexity and fractal correlation properties of R-R interval time series comparable to those of young adults, despite lower overall heart rate variability. Healthy aging is associated with R-R interval dynamics showing higher regularity and altered fractal scaling consistent with a loss of complex variability.

Posterior white matter disease distribution as a predictor of amyloid angiopathy

PubMed Central

Thanprasertsuk, Sekh; Martinez-Ramirez, Sergi; Pontes-Neto, Octavio Marques; Ni, Jun; Ayres, Alison; Reed, Anne; Swords, Kyleen; Gurol, M. Edip; Greenberg, Steven M.

2014-01-01

Objectives: We sought to examine whether a posterior distribution of white matter hyperintensities (WMH) is an independent predictor of pathologically confirmed cerebral amyloid angiopathy (CAA) and whether it is associated with MRI markers of CAA, in patients without lobar intracerebral hemorrhage. Methods: We developed a quantitative method to measure anteroposterior (AP) distribution of WMH. A retrospective cohort of patients without intracerebral hemorrhage and with pathologic evaluation of CAA was examined to determine whether posterior WMH distribution was an independent predictor of CAA (n = 59). The relationship of AP distributions of WMH to strictly lobar microbleeds (MBs) (n = 259) and location of dilated perivascular spaces (DPVS) (n = 85) was examined in a separate cohort of patients evaluated in a memory clinic. Results: A more posterior WMH distribution was found to be an independent predictor of pathologic evidence of CAA (p = 0.001, odds ratio [95% confidence interval] = 1.19 [1.07–1.32]), even in the subgroup without lobar MBs (p = 0.016, odds ratio [95% confidence interval] = 1.18 [1.03–1.36]). In the memory clinic cohort, strictly lobar MBs were independently associated with more posterior WMH distribution (p = 0.009). AP distribution of WMH was also associated with location of DPVS (p = 0.001), in that patients with predominant DPVS in the white matter over the basal ganglia harbored a more posterior WMH distribution. Conclusions: Our results suggest that AP distribution of WMH may represent an additional marker of CAA, irrespective of the presence of lobar hemorrhages. Classification of evidence: This study provides Class III evidence that there is a significant association between the AP distribution of WMH on MRI with the presence of pathologically confirmed CAA pathology. PMID:25063759

Monty Roberts' Public Demonstrations: Preliminary Report on the Heart Rate and Heart Rate Variability of Horses Undergoing Training during Live Audience Events.

PubMed

Loftus, Loni; Marks, Kelly; Jones-McVey, Rosie; Gonzales, Jose L; Fowler, Veronica L

2016-09-09

Effective training of horses relies on the trainer's awareness of learning theory and equine ethology, and should be undertaken with skill and time. Some trainers, such as Monty Roberts, share their methods through the medium of public demonstrations. This paper describes the opportunistic analysis of beat-to-beat (RR) intervals and heart rate variability (HRV) of ten horses being used in Monty Roberts' public demonstrations within the United Kingdom. RR and HRV was measured in the stable before training and during training. The HRV variables standard deviation of the RR interval (SDRR), root mean square of successive RR differences (RMSSD), geometric means standard deviation 1 (SD1) and 2 (SD2), along with the low and high frequency ratio (LF/HF ratio) were calculated. The minimum, average and maximum RR intervals were significantly lower in training (indicative of an increase in heart rate as measured in beats-per-minute) than in the stable ( p = 0.0006; p = 0.01; p = 0.03). SDRR, RMSSD, SD1, SD2 and the LF/HF ratio were all significantly lower in training than in the stable ( p = 0.001; p = 0.049; p = 0.049; p = 0.001; p = 0.01). When comparing the HR and HRV of horses during Join-up (®) to overall training, there were no significant differences in any variable with the exception of maximum RR which was significantly lower ( p = 0.007) during Join-up (®) , indicative of short increases in physical exertion (canter) associated with this training exercise. In conclusion, training of horses during public demonstrations is a low-moderate physiological, rather than psychological stressor for horses. The physiological stress responses observed within this study were comparable or less to those previously reported in the literature for horses being trained outside of public audience events. Furthermore, there is no evidence that the use of Join-up (®) alters HR and HRV in a way to suggest that this training method negatively affects the psychological welfare of horses.

Hydrocortisone at stress-associated concentrations helps maintain human heart rate variability during subsequent endotoxin challenge.

PubMed

Rassias, Athos J; Guyre, Paul M; Yeager, Mark P

2011-12-01

We evaluated the differential impact of stress-associated vs high pharmacologic concentrations of hydrocortisone pretreatment on heart rate variability (HRV) during a subsequent systemic inflammatory stimulus. Healthy volunteers were randomized to receive placebo (Control) and hydrocortisone at 1.5 μg/kg per minute (STRESS) or at 3.0 μg/kg per minute (PHARM) as a 6-hour infusion. The STRESS dose was chosen to replicate the condition of physiologic adrenal cortical output during acute systemic stress. The PHARM dose was chosen to induce a supraphysiologic concentration of cortisol. The next day, all subjects received 2 ng/kg Escherichia coli endotoxin (lipopolysaccharide). Heart rate variability was analyzed with the statistic approximate entropy (ApEn). A lower ApEn correlates with decreased HRV. At the 3-hour nadir, the decrease in ApEn in the STRESS group was significantly less compared to placebo (P < .03), whereas ApEn in the PHARM group was not statistically different. We also found that the maximal decrease in ApEn preceded maximal increase in heart rate in all groups. The decrease in R-R interval was maximal at 4 hours, whereas the ApEn nadir was 1 hour earlier at 3 hours. Pretreatment with a stress dose of hydrocortisone but not a higher pharmacologic dose maintained a significantly higher ApEn after endotoxin exposure when compared to a placebo. In addition, decreases in ApEn preceded increases in heart rate. Copyright © 2011 Elsevier Inc. All rights reserved.

Human bone marrow-derived clonal mesenchymal stem cells inhibit inflammation and reduce acute pancreatitis in rats.

PubMed

Jung, Kyung Hee; Song, Sun U; Yi, Tacghee; Jeon, Myung-Shin; Hong, Sang-Won; Zheng, Hong-Mei; Lee, Hee-Seung; Choi, Myung-Joo; Lee, Don-Haeng; Hong, Soon-Sun

2011-03-01

Acute pancreatitis (AP) has a high mortality rate; repetitive AP induces chronic AP and pancreatic adenocarcinoma. Mesenchymal stem cells (MSCs) have immunoregulatory effects and reduce inflammation. We developed a protocol to isolate human bone marrow-derived clonal MSCs (hcMSCs) from bone marrow aspirate and investigated the effects of these cells in rat models of mild and severe AP. Mild AP was induced in Sprague-Dawley rats by 3 intraperitoneal injections of cerulein (100 μg/kg), given at 2-hour intervals; severe AP was induced by intraparenchymal injection of 3% sodium taurocholate solution. hcMSCs were labeled with CM-1,1'-dioctadecyl-3,3,3'-tetramethylindo-carbocyanine perchloride and administered to rats through the tail vein. hcMSCs underwent self-renewal and had multipotent differentiation capacities and immunoregulatory functions. Greater numbers of infused hcMSCs were detected in pancreas of rats with mild and severe AP than of control rats. Infused hcMSCs reduced acinar-cell degeneration, pancreatic edema, and inflammatory cell infiltration in each model of pancreatitis. The hcMSCs reduced expression of inflammation mediators and cytokines in rats with mild and severe AP. hcMSCs suppressed the mixed lymphocyte reaction and increased expression of Foxp3(+) (a marker of regulatory T cells) in cultured rat lymph node cells. Rats with mild or severe AP that were given infusions of hcMSCs had reduced numbers of CD3(+) T cells and increased expression of Foxp3(+) in pancreas tissues. hcMSCs reduced inflammation and damage to pancreatic tissue in a rat model of AP; they reduced levels of cytokines and induced numbers of Foxp3(+) regulatory T cells. hcMSCs might be developed as a cell therapy for pancreatitis. Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.

Frequency and correlates of DSM-5 attenuated psychosis syndrome in a sample of adolescent inpatients with nonpsychotic psychiatric disorders.

PubMed

Gerstenberg, Miriam; Hauser, Marta; Al-Jadiri, Aseel; Sheridan, Eva M; Kishimoto, Taishiro; Borenstein, Yehonatan; Vernal, Ditte L; David, Lisa; Saito, Ema; Landers, Sara E; Carella, Morgan; Singh, Sukhbir; Carbon, Maren; Jiménez-Fernández, Sara; Birnbaum, Michael L; Auther, Andrea; Carrión, Ricardo E; Cornblatt, Barbara A; Kane, John M; Walitza, Susanne; Correll, Christoph U

2015-11-01

DSM-5 conceptualized attenuated psychosis syndrome (APS) as self-contained rather than as a risk syndrome, including it under "Conditions for Further Study," but also as a codable/billable condition in the main section. Since many major mental disorders emerge during adolescence, we assessed the frequency and characteristics of APS in adolescent psychiatric inpatients. Consecutively recruited adolescents hospitalized for nonpsychotic disorders (September 2009-May 2013) were divided into APS youth versus non-APS youth, based on the Structured Interview of Prodromal Syndromes (SIPS) and according to DSM-5 criteria, and compared across multiple characteristics. Of 89 adolescents (mean ± SD age = 15.1 ± 1.6 years), 21 (23.6%) had APS. Compared to non-APS, APS was associated with more comorbid disorders (2.7 ± 1.0 vs 2.2 ± 1.3), major depressive disorder (61.9% vs 27.9%), oppositional defiant disorder/conduct disorder (52.4% vs 25.0%), and personality disorder traits (57.1% vs 7.4%, the only diagnostic category surviving Bonferroni correction). APS youth were more severely ill, having higher SIPS total positive, negative, and general symptoms; Brief Psychiatric Rating Scale total and positive scores; depression and global illness ratings; and lower Global Assessment of Functioning (GAF). Conversely, Young Mania Rating Scale scores, suicidal behavior, prescribed psychotropic medications, and mental disorder awareness were similar between APS and non-APS groups. In multivariable analysis, lowest GAF score in the past year (odds ratio [OR] = 51.15; 95% confidence interval [CI], 2.46-2,439.0) and social isolation (OR = 27.52; 95% CI, 3.36-313.87) were independently associated with APS (r(2) = 0.302, P < .0001). Although psychotic disorders were excluded, 65.2% (APS = 57.1%, non-APS = 67.7%, P = .38) received antipsychotics. One in 4 nonpsychotic adolescent inpatients met DSM-5 criteria for APS. APS youth were more impaired, showing a complex entanglement with a broad range of psychiatric symptoms and disorders, including depression, impulse-control, and, especially, emerging personality disorders. ClinicalTrials.gov identifier: NCT01383915. © Copyright 2015 Physicians Postgraduate Press, Inc.

Retrospective study of the clinical effects of acupuncture on cervical neurological diseases in dogs.

PubMed

Liu, Ching Ming; Chang, Fang Chia; Lin, Chung Tien

2016-09-30

This study was conducted to evaluate new acupuncture protocols for the clinical treatment of cervical spinal cord diseases in 19 dogs. Three treatment options containing Jing-jiaji (cervical jiaji) were developed to treat neck pain, hemiparesis, and tetraparesis depending on the severity. The interval between the neurological disease onset and treatment (duration of signs), time to improvement after treatment, and recovery time were compared in dogs by body weight, age, and dry needle acupuncture (AP) with or without electro-AP (EAP). The duration of signs was longer in dogs weighing greater than 10 kg than in those weighing less than 10 kg (p＜ 0.05). Improvement and recovery times did not vary by body weight. Additionally, improvement and recovery times did not vary by age. The improvement and recovery times were longer in the AP+EAP group than the AP group (p＜ 0.05). Acupuncture with Jing-jiaji was effective in cervical spinal cord diseases in different sized dogs and in middle-aged and senior dogs. This report standardized AP treatment containing Jing-jiaji for canine cervical problems and evaluated its effects. The newly standardized AP methodology offers clinical practitioners an effective way to improve the outcomes of cervical neurological diseases in dogs.

Risk of development of acute pancreatitis with pre-existing diabetes: a meta-analysis.

PubMed

Xue, Yuzheng; Sheng, Yingyue; Dai, Hong; Cao, Haiyan; Liu, Zongliang; Li, Zhaoshen

2012-09-01

It is well established that acute pancreatitis (AP) often causes diabetes mellitus. However, whether pre-existing diabetes is associated with the development of AP remains unknown. To clarify the association of pre-existing diabetes and the development of AP, we carried out a meta-analysis of observational studies. A computerized literature search was performed in MEDLINE (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 January 2012. We also searched the reference lists of relevant articles. Summary relative risks with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I 2. A total of seven articles (10 523 incident cases of AP) were included in this meta-analysis. Analysis of seven studies indicated that, compared with nondiabetic individuals, diabetic individuals had a 92% increased risk of development of AP (95% CI 1.50-2.47). There was significant evidence of heterogeneity among these studies (P heterogeneity<0.001, I 2=93.0%). These increased risks were independent of alcohol use, gallstones, and hyperlipidemia. Although the current evidence supports a positive link between pre-existing diabetes and an increased risk of development of AP, additional studies, with a perfect design, are required before definitive conclusions can be drawn.

Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis.

PubMed

Sankaran, Sharanya J; Xiao, Amy Y; Wu, Landy M; Windsor, John A; Forsmark, Christopher E; Petrov, Maxim S

2015-11-01

Acute pancreatitis (AP) and chronic pancreatitis (CP) traditionally have been thought to be distinct diseases, but there is evidence that AP can progress to CP. Little is known about the mechanisms of pancreatitis progression. We performed a meta-analysis to quantify the frequency of transition of AP to CP and identify risk factors for progression. We searched PubMed, Scopus, and Embase for studies of patients with AP who developed CP, published from 1966 through November 2014. Pooled prevalence and 95% confidence intervals (CIs) were calculated for these outcomes, and sensitivity, subgroup, and meta-regression analyses were conducted. We analyzed 14 studies, which included a total of 8492 patients. The pooled prevalence of recurrent AP was 22% (95% CI, 18%-26%), and the pooled prevalence of CP was 10% (95% CI, 6%-15%). Sensitivity analyses yielded a pooled prevalence of CP of 10% (95% CI, 4%-19%) and 36% (95% CI, 20%-53%) in patients after the first occurrence and recurrent AP, respectively. Subgroup analyses found alcohol use and smoking to be the largest risk factors for the development of CP, with pooled prevalence values of 65% (95% CI, 48%-56%) and 61% (95% CI, 47%-73%), respectively. Meta-regression analysis found that men were more likely than women to transition from AP to CP. Ten percent of patients with a first episode of AP and 36% of patients with recurrent AP develop CP; the risk is higher among smokers, alcoholics, and men. Prospective clinical studies are needed to study pancreatitis progression. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

Venous access and long-term pacemaker lead failure: comparing contrast-guided axillary vein puncture with subclavian puncture and cephalic cutdown.

PubMed

Chan, Ngai-Yin; Kwong, Nim-Pong; Cheong, Adrian-Piers

2017-07-01

Existing data on the relationship between venous access and long-term pacemaker lead failure (PLF) are scarce and inconsistent. We aim to study the hypothesis that contrast-guided axillary vein puncture (AP) is better than subclavian puncture (SP) and similar to cephalic vein cutdown (CV) in the incidence of PLF and the success rate of AP is higher than CV. The case records of 409 patients with 681 implantable pacemaker leads were reviewed. Two hundred and fifty-two, 217, and 212 leads were implanted via AP, CV, and SP, respectively. With a mean follow-up of 73.6 ± 33.1 months, 20 (2.9%) PLF occurred. Three (1.2%), 5 (2.3%), and 12 (5.6%) PLF occurred in the AP, CV, and SP groups, respectively. On multivariate Cox regression analysis, the only independent predictor for PLF was the use of SP instead of AP (AP vs. SP; hazard ratio: 0.261; 95% confidence interval: 0.071-0.954, P = 0.042). The success rate of CV (78.2%) was significantly lower than those of AP (97.6%) and SP (96.8%) (P < 0.001). Compared with SP, the use of AP but not CV independently predicted a lower risk of PLF. The success rates in achieving venous accesses were similar between AP and SP, but significantly lower for CV. Axillary vein puncture may thus be considered the venous access of choice for pacemaker lead implantation. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort.

PubMed

Setiawan, Veronica Wendy; Pandol, Stephen J; Porcel, Jacqueline; Wei, Pengxiao C; Wilkens, Lynne R; Le Marchand, Loïc; Pike, Malcolm C; Monroe, Kristine R

2017-02-01

Pancreatitis is a source of substantial morbidity and health cost in the United States. Little is known about how diet might contribute to its pathogenesis. To characterize dietary factors that are associated with risk of pancreatitis by disease subtype, we conducted a prospective analysis of 145,886 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the Multiethnic Cohort. In the Multiethnic Cohort (age at baseline, 45-75 y), we identified cases of pancreatitis using hospitalization claim files from 1993 through 2012. Patients were categorized as having gallstone-related acute pancreatitis (AP) (n = 1210), AP not related to gallstones (n = 1222), or recurrent AP or suspected chronic pancreatitis (n = 378). Diet information was obtained from a questionnaire administered when the study began. Associations were estimated by hazard ratios and 95% confidence intervals using Cox proportional hazard models adjusted for confounders. Dietary intakes of saturated fat (P trend = .0011) and cholesterol (P trend = .0008) and their food sources, including red meat (P trend < .0001) and eggs (P trend = .0052), were associated positively with gallstone-related AP. Fiber intake, however, was associated inversely with gallstone-related AP (P trend = .0005) and AP not related to gallstones (P trend = .0035). Vitamin D, mainly from milk, was associated inversely with gallstone-related AP (P trend = .0015), whereas coffee consumption protected against AP not related to gallstones (P trend < .0001). With the exception of red meat, no other dietary factors were associated with recurrent acute or suspected chronic pancreatitis. Associations between dietary factors and pancreatitis were observed mainly for gallstone-related AP. Interestingly, dietary fiber protected against AP related and unrelated to gallstones. Coffee drinking protected against AP not associated with gallstones. Further studies are warranted to confirm our findings. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Heart Failure with Preserved Ejection Fraction: Comparison of Patients With and Without Angina Pectoris (From the Duke Databank for Cardiovascular Disease)

PubMed Central

Mentz, Robert J.; Broderick, Samuel; Shaw, Linda K.; Fiuzat, Mona; O'Connor, Christopher M.

2013-01-01

Objectives We aimed to investigate the characteristics and outcomes of patients with heart failure with preserved ejection fraction (HFpEF) and angina pectoris (AP). Background AP is a predictor of adverse events in patients with heart failure with reduced EF. The implications of AP in HFpEF are unknown. Methods We analyzed HFpEF patients (EF≥50%) who underwent coronary angiography at Duke University Medical Center from 2000–2010 with and without AP in the previous 6 weeks. Time to first event was examined using Kaplan-Meier methods for the primary endpoint of death/myocardial infarction (MI)/revascularization/stroke (i.e., MACE) and secondary endpoints of death/MI/revascularization, death/MI/stroke, death/MI, death and cardiovascular death/cardiovascular hospitalization. Results In the Duke Databank, 3517 patients met criteria for inclusion and 1402 (40%) had AP. Those with AP were older with more comorbidities, and prior revascularization vs. non-AP patients. AP patients more often received beta-blockers, ACE-inhibitors, nitrates, and statins (all P<0.05). In unadjusted analysis, AP patients had increased MACE and death/MI/revascularization (both P <0.001), lower rates of death and death/MI (both P<0.05), and similar rates of death/MI/stroke and cardiovascular death/cardiovascular hospitalization (both P>0.1). After multivariable adjustment, those with AP remained at increased risk for MACE (Hazard Ratio [HR] 1.30; 95% Confidence Interval [CI], 1.17–1.45) and death/MI/revascularization (HR 1.29; 95% CI, 1.15–1.43), but were at similar risk for other endpoints (P>0.06). Conclusions AP in HFpEF patients with a history of coronary artery disease is common despite medical therapy and is independently associated with increased MACE due to revascularization with similar risk of death, MI, and hospitalization. PMID:24161322

VizieR Online Data Catalog: Final Kepler transiting planet search (DR25) (Twicken+, 2016)

NASA Astrophysics Data System (ADS)

Twicken, J. D.; Jenkins, J. M.; Seader, S. E.; Tenenbaum, P.; Smith, J. C.; Brownston, L. S.; Burke, C. J.; Catanzarite, J. H.; Clarke, B. D.; Cote, M. T.; Girouard, F. R.; Klaus, T. C.; Li, J.; McCauliff, S. D.; Morris, R. L.; Wohler, B.; Campbell, J. R.; Uddin, A. K.; Zamudio, K. A.; Sabale, A.; Bryson, S. T.; Caldwell, D. A.; Christiansen, J. L.; Coughlin, J. L.; Haas, M. R.; Henze, C. E.; Sanderfer, D. T.; Thompson, S. E.

2017-01-01

The Kepler spacecraft is in an Earth-trailing heliocentric orbit and maintained a boresight pointing centered on α=19h22m40s, δ=+44.5° during the primary mission. The Kepler photometer acquired data on a 115-square-degree region of the sky. The data were acquired on 29.4-minute intervals, colloquially known as "long cadences". Long-cadence pixel values were obtained by accumulating 270 consecutive 6.02s exposures. Science acquisition of Q1 data began at 2009-05-13 00:01:07Z, and acquisition of Q17 data concluded at 2013-05-11 12:16:22Z. This time period contains 71427 long-cadence intervals. A total of 198709 targets observed by Kepler were searched for evidence of transiting planets in the final Q1-Q17 pipeline run (see Table1). The results of past Kepler Mission transiting planet searches have been presented in Tenenbaum et al. 2012 (Cat. J/ApJS/199/24) for Quarter 1 through Quarter 3 (i.e., Q1-Q3), Tenenbaum et al. 2013ApJS..206....5T for Q1-Q12, Tenenbaum et al. 2014ApJS..211....6T for Q1-Q16, and Seader et al. 2015 (Cat. J/ApJS/217/18) for Q1-Q17. We now present results of the final Kepler transiting planet search encompassing the complete 17-quarter primary mission. The data release for the final Q1-Q17 pipeline processing is referred to as Data Release 25 (DR25). (3 data files).

Does Tibial Slope Affect Perception of Coronal Alignment on a Standing Anteroposterior Radiograph?

PubMed

Schwartz, Adam J; Ravi, Bheeshma; Kransdorf, Mark J; Clarke, Henry D

2017-07-01

A standing anteroposterior (AP) radiograph is commonly used to evaluate coronal alignment following total knee arthroplasty (TKA). The impact of coronal alignment on TKA outcomes is controversial, perhaps due to variability in imaging and/or measurement technique. We sought to quantify the effect of image rotation and tibial slope on coronal alignment. Using a standard extramedullary tibial alignment guide, 3 cadaver legs were cut to accept a tibial tray at 0°, 3°, and 7° of slope. A computed tomography scan of the entire tibia was obtained for each specimen to confirm neutral coronal alignment. Images were then obtained at progressive 10° intervals of internal and external rotation up to 40° maximum in each direction. Images were then randomized and 5 blinded TKA surgeons were asked to determine coronal alignment. Continuous data values were transformed to categorical data (neutral [0], valgus [L], and varus [R]). Each 10° interval of external rotation of a 7° sloped tibial cut (or relative internal rotation of a tibial component viewed in the AP plane) resulted in perception of an additional 0.75° of varus. The slope of the proximal tibia bone cut should be taken into account when measuring coronal alignment on a standing AP radiograph. Copyright © 2017 Elsevier Inc. All rights reserved.

Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers.

PubMed

Khan, H; Akhtar, N; Ali, A

2017-01-01

The skin is fortified with a setup of lipophilic and hydrophilic, enzymatic and non-enzymatic antioxidant systems. Ascorbyl palmitate (AP) and sodium ascorbyl phosphate (SAP) are reported as lipophilic and hydrophilic antioxidants, respectively used for skin care. Present study was aimed to assess the combined AP (in oil phase) and SAP (in aqueous phase) via multiple emulsion (ME 1 ) for controlling sebum secretions in healthy human females. FTIR analysis of AP and SAP was performed for identification. Multiple emulsions (ME 1 and control) were prepared and analyzed for physical stability. Antioxidant activities of AP, SAP as well as ME 1 (with combination of these compounds) were determined by DPPH method. 11 female volunteers were included in a single-blinded, placebo-controlled, split-face comparative study. Volunteers were instructed to apply ME 1 on left cheek while control (without AP and SAP) on right cheek, for a period of 90 days. A non-invasive photometric device (Sebumeter ® ) was used for the measurement of sebum secretions on both sides of the face with subsequent time intervals. A good antioxidant activity of ME 1 was observed. ME 1 treatments reduced significant facial sebum secretions as compared with control/placebo treatments. It was concluded that combined AP and SAP supplementations to skin proved a promising choice for controlling facial sebum secretions and could be evaluated for undesired oily skin and acne reductions for beautifying the facial appearance. © Georg Thieme Verlag KG Stuttgart · New York.

Anti-emetic effect of oculo-acupuncture on dogs with xylazine induced vomiting.

PubMed

Liu, Jianzhu; Lee, Yoo-Teak; Lee, Sang-Eun; Lee, Jung-Yeon; Kim, Duck-Hwan

2007-01-01

The present study was conducted in order to clarify the anti-emetic effect of oculo-acupuncture (OA) on dogs with xylazine-induced vomiting, and also to compare the anti-emetic effect of OA and body acupuncture (AP). Twelve dogs induced to vomit by xylazine were selected from total 29 mongrel dogs in preliminary experiment and were used as subjects in this study. This study was comprised of two experiments. In experiment 1, the anti-emetic effects of OA on dogs were examined in the stomach/spleen region (experimental group I), the zhongjiao region (experimental group II), and the stomach/spleen region plus the zhongjiao region (experimental group III) using 12 dogs induced to vomit for one week interval repeatedly. On the other hand, needle acupuncture (AP) (BL20 + BL21, experimental group A) and OA (stomach/spleen and zhong jiao regions) combined with needle AP (BL20 + BL21) (experimental group B) were examined using 6 vomiting dogs, for one week interval repeatedly in experiment 2. As a result, the vomiting rates of experimental group I (50%, p < 0.05), experimental group II (58.3%) and experimental group III (41.6%, p < 0.01) were lower than that of control (100%), respectively in experiment 1. The vomiting rates of both experimental group A (50%, p < 0.05) and experimental group B (50%, p < 0.05) were lower than that of control (100%) in experiment 2. The starting vomiting time in experimental groups was similar to that of the control groups in experiment 1 and 2. This study demonstrated that OA had anti-emetic effects on dogs with xylazine-induced vomiting and OA in the stomach/spleen region plus the zhongjiao region was the most effective in anti-emesis among the experimental groups. In addition, body AP and OA combined with body AP had a similar anti-emetic effect on dogs with xylazine-induced vomiting.

VizieR Online Data Catalog: 44 SZ-selected galaxy clusters ACT observations (Sifon+, 2016)

NASA Astrophysics Data System (ADS)

Sifon, C.; Battaglia, N.; Hasselfield, M.; Menanteau, F.; Barrientos, L. F.; Bond, J. R.; Crichton, D.; Devlin, M. J.; Dunner, R.; Hilton, M.; Hincks, A. D.; Hlozek, R.; Huffenberger, K. M.; Hughes, J. P.; Infante, L.; Kosowsky, A.; Marsden, D.; Marriage, T. A.; Moodley, K.; Niemack, M. D.; Page, L. A.; Spergel, D. N.; Staggs, S. T.; Trac, H.; Wollack, E. J.

2017-11-01

ACT is a 6-metre off-axis Gregorian telescope located at an altitude of 5200um in the Atacama desert in Chile, designed to observe the CMB at arcminute resolution. Galaxy clusters were detected in the 148GHz band by matched-filtering the maps with the pressure profile suggested by Arnaud et al. (2010A&A...517A..92A), fit to X-ray selected local (z<0.2) clusters, with varying cluster sizes,θ500, from 1.18 to 27-arcmin. Because of the complete overlap of ACT equatorial observations with Sloan Digital Sky Survey Data Release 8 (SDSS DR8; Aihara et al., 2011ApJS..193...29A) imaging, all cluster candidates were assessed with optical data (Menanteau et al., 2013ApJ...765...67M). We observed 20 clusters from the equatorial sample with the Gemini Multi-Object Spectrograph (GMOS) on the Gemini-South telescope, split in semesters 2011B (ObsID:GS-2011B-C-1, PI:Barrientos/Menanteau) and 2012A (ObsID:GS-2012A-C-1, PI:Menanteau), prioritizing clusters in the cosmological sample at 0.3

Cholinergic stimulation with pyridostigmine protects myocardial infarcted rats against ischemic-induced arrhythmias and preserves connexin43 protein.

PubMed

Santos-Almeida, Fernanda Machado; Girão, Henrique; da Silva, Carlos Alberto Aguiar; Salgado, Helio Cesar; Fazan, Rubens

2015-01-15

We investigated the effects of acute pyridostigmine (PYR) treatment, an acetylcholinesterase inhibitor, on arterial pressure (AP), heart rate (HR), cardiac sympathovagal balance, and the incidence of arrhythmias during the first 4 h after myocardial infarction (MI) in anesthetized rats. Male Wistar rats were implanted with catheters into the femoral artery and vein for AP recordings and drug administration. Rats received the autonomic receptor blockers methyl-atropine (1 mg/kg iv) and propranolol (2 mg/kg iv) at intervals of 15 min, 1 h after saline (n=16) or PYR (0.25 mg/kg iv, n=18), to indirectly assess sympathovagal balance. Acute treatment with PYR increased cardiac vagal (86±7 vs. 44±5 beats/min) and decreased sympathetic tone (-31±8 vs. -69±7 beats/min). Different animals were implanted with ECG electrodes and catheters. A large MI was induced via left coronary artery ligation after basal recordings. Rats received PYR (n=14) or saline (n=14) 10-15 min after MI, and the recordings lasted up to 4 h. In part of the animals, hearts were removed for connexin43 quantification after all procedures. MI elicited a fall in AP (-45±5 mmHg), a progressive rise in HR (26±14 beats/min), and an increase in corrected QT interval (33±13 ms). PYR elicited a prompt bradycardia (-50±14 beats/min) that returned to basal levels over time, and it prevented the lengthening of the corrected QT interval. Treatment with PYR increased by ∼20% the occurrence of rats free of arrhythmias after MI. MI markedly decreased connexin43 in left ventricles, and PYR treatment partially prevented this decrease. Copyright © 2015 the American Physiological Society.

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.

PubMed

Toib, Amir; Zhang, Chen; Borghetti, Giulia; Zhang, Xiaoxiao; Wallner, Markus; Yang, Yijun; Troupes, Constantine D; Kubo, Hajime; Sharp, Thomas E; Feldsott, Eric; Berretta, Remus M; Zalavadia, Neil; Trappanese, Danielle M; Harper, Shavonn; Gross, Polina; Chen, Xiongwen; Mohsin, Sadia; Houser, Steven R

2017-09-01

Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac diseases and among the leading causes of sudden cardiac death (SCD) in the young. The cellular mechanisms leading to SCD in HCM are not well known. Prolongation of the action potential (AP) duration (APD) is a common feature predisposing hypertrophied hearts to SCD. Previous studies have explored the roles of inward Na + and Ca 2+ in the development of HCM, but the role of repolarizing K + currents has not been defined. The objective of this study was to characterize the arrhythmogenic phenotype and cellular electrophysiological properties of mice with HCM, induced by myosin-binding protein C (MyBPC) knockout (KO), and to test the hypothesis that remodeling of repolarizing K + currents causes APD prolongation in MyBPC KO myocytes. We demonstrated that MyBPC KO mice developed severe hypertrophy and cardiac dysfunction compared with wild-type (WT) control mice. Telemetric electrocardiographic recordings of awake mice revealed prolongation of the corrected QT interval in the KO compared with WT control mice, with overt ventricular arrhythmias. Whole cell current- and voltage-clamp experiments comparing KO with WT mice demonstrated ventricular myocyte hypertrophy, AP prolongation, and decreased repolarizing K + currents. Quantitative RT-PCR analysis revealed decreased mRNA levels of several key K + channel subunits. In conclusion, decrease in repolarizing K + currents in MyBPC KO ventricular myocytes contributes to AP and corrected QT interval prolongation and could account for the arrhythmia susceptibility. NEW & NOTEWORTHY Ventricular myocytes isolated from the myosin-binding protein C knockout hypertrophic cardiomyopathy mouse model demonstrate decreased repolarizing K + currents and action potential and QT interval prolongation, linking cellular repolarization abnormalities with arrhythmia susceptibility and the risk for sudden cardiac death in hypertrophic cardiomyopathy. Copyright © 2017 the American Physiological Society.

Effect of the Anti-depressant Sertraline, the Novel Anti-seizure Drug Vinpocetine and Several Conventional Antiepileptic Drugs on the Epileptiform EEG Activity Induced by 4-Aminopyridine.

PubMed

Sitges, Maria; Aldana, Blanca Irene; Reed, Ronald Charles

2016-06-01

Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sertraline, and the anti-seizure drug vinpocetine are effective inhibitors of cerebral presynaptic Na(+) channels. Here the effectiveness of these compounds to prevent the epileptiform EEG activity induced by 4-AP was compared with the effectiveness of seven conventional antiepileptic drugs. For this purpose, EEG recordings before and at three intervals within the next 30 min following 4-AP (2.5 mg/kg, i.p.) were taken in anesthetized animals; and the EEG-highest peak amplitude values (HPAV) calculated. In control animals, the marked increase in the EEG-HPAV observed near 20 min following 4-AP reached its maximum at 30 min. Results show that this epileptiform EEG activity induced by 4-AP is prevented by sertraline and vinpocetine at a dose of 2.5 mg/kg, and by carbamazepine, phenytoin, lamotrigine and oxcarbazepine at a higher dose (25 mg/kg). In contrast, topiramate (25 mg/kg), valproate (100 mg/kg) and levetiracetam (100 mg/kg) failed to prevent the epileptiform EEG activity induced by 4-AP. It is concluded that 4-AP is a useful tool to elicit the mechanism of action of anti-seizure drugs at clinical meaningful doses. The particular efficacy of sertraline and vinpocetine to prevent seizures induced by 4-AP is explained by their high effectiveness to reduce brain presynaptic Na(+) and Ca(2+) channels permeability.

The association of depression and angina pectoris across 47 countries: findings from the 2002 World Health Survey.

PubMed

Loerbroks, Adrian; Bosch, Jos Antonio; Mommersteeg, Paula Maria Christina; Herr, Raphael Manfred; Angerer, Peter; Li, Jian

2014-07-01

Comorbid depression predicts poor health outcomes in patients with angina pectoris (AP). However, epidemiological data on the depression-AP comorbidity is limited and largely restricted to studies from Western countries, making generalizability to other regions uncertain. We aimed to provide additional epidemiological data for non-Western as well as Western countries. The present study used population-based data gathered in 47 countries from four continents (Africa, Asia, South America, and Europe) included in the cross-sectional 2002 WHO World Health Survey. Self-reported indicators of depression included: (a) its diagnosis, (b) its treatment, and (c) seven symptom items to determine presence of a major depressive episode. Similarly, information on AP comprised (a) a self-reported diagnosis, (b) self-reported AP treatment, (c) and a definition according to the WHO Rose questionnaire. In primary analyses, we operationalized depression or AP as positive if any of the respective indicators was present. Associations were estimated by multivariate logistic regression. In the entire sample (n = 213,264), the odds of AP were more than doubled among those with depression [odds ratio (OR) = 2.60, 95% confidence interval = 2.36, 2.87] versus those without depression. These positive associations were replicated across all continents and were observed in both men and women. Likewise, meaningful associations (ORs ≥ 1.5) were observed in virtually all individual countries (46/47). Application of different operationalizations of depression and AP confirmed the above findings, both in the entire sample and in continent-specific analyses. Our study extends the current evidence accrued in Western populations to non-Western populations. The co-occurrence of AP and depression appears to represent a universal phenomenon.

The Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans

PubMed Central

Smith, J. Gustav; Avery, Christy L.; Evans, Daniel S.; Nalls, Michael A.; Meng, Yan A.; Smith, Erin N.; Palmer, Cameron; Tanaka, Toshiko; Mehra, Reena; Butler, Anne M.; Young, Taylor; Buxbaum, Sarah G.; Kerr, Kathleen F.; Berenson, Gerald S.; Schnabel, Renate B.; Li, Guo; Ellinor, Patrick T.; Magnani, Jared W.; Chen, Wei; Bis, Joshua C.; Curb, J. David; Hsueh, Wen-Chi; Rotter, Jerome I.; Liu, Yongmei; Newman, Anne B.; Limacher, Marian C.; North, Kari E.; Reiner, Alexander P.; Quibrera, P. Miguel; Schork, Nicholas J.; Singleton, Andrew B.; Psaty, Bruce M.; Soliman, Elsayed Z.; Solomon, Allen J.; Srinivasan, Sathanur R.; Alonso, Alvaro; Wallace, Robert; Redline, Susan; Zhang, Zhu-Ming; Post, Wendy S.; Zonderman, Alan B.; Taylor, Herman A.; Murray, Sarah S.; Ferrucci, Luigi; Arking, Dan E.; Evans, Michele K.; Fox, Ervin R.; Sotoodehnia, Nona; Heckbert, Susan R.; Whitsel, Eric A.; Newton-Cheh, Christopher

2013-01-01

Background Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death (SCD) and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval. Methods and Results First, individual estimates of African and European ancestry were inferred from genome-wide single nucleotide polymorphism (SNP) data in seven population-based cohorts of African Americans (n=12 097) and regressed on measured QT interval from electrocardiograms. Second, imputation was performed for 2.8 million SNPs and a genome-wide association (GWA) study of QT interval performed in ten cohorts (n=13 105). There was no evidence of association between genetic ancestry and QT interval (p=0.94). Genome-wide significant associations (p<2.5×10−8) were identified with SNPs at two loci, upstream of the genes NOS1AP (rs12143842, p=2×10−15) and ATP1B1 (rs1320976, p=2×10−10). The most significant SNP in NOS1AP was the same as the strongest SNP previously associated with QT interval in individuals of European ancestry. Low p-values (p<10−5) were observed for SNPs at several other loci previously identified in GWA studies in individuals of European ancestry, including KCNQ1, KCNH2, LITAF and PLN. Conclusions We observed no difference in duration of cardiac repolarization with global genetic indices of African ancestry. In addition, our GWA study extends the association of polymorphisms at several loci associated with repolarization in individuals of European ancestry to include African Americans. PMID:23166209

Impact of ancestry and common genetic variants on QT interval in African Americans.

PubMed

Smith, J Gustav; Avery, Christy L; Evans, Daniel S; Nalls, Michael A; Meng, Yan A; Smith, Erin N; Palmer, Cameron; Tanaka, Toshiko; Mehra, Reena; Butler, Anne M; Young, Taylor; Buxbaum, Sarah G; Kerr, Kathleen F; Berenson, Gerald S; Schnabel, Renate B; Li, Guo; Ellinor, Patrick T; Magnani, Jared W; Chen, Wei; Bis, Joshua C; Curb, J David; Hsueh, Wen-Chi; Rotter, Jerome I; Liu, Yongmei; Newman, Anne B; Limacher, Marian C; North, Kari E; Reiner, Alexander P; Quibrera, P Miguel; Schork, Nicholas J; Singleton, Andrew B; Psaty, Bruce M; Soliman, Elsayed Z; Solomon, Allen J; Srinivasan, Sathanur R; Alonso, Alvaro; Wallace, Robert; Redline, Susan; Zhang, Zhu-Ming; Post, Wendy S; Zonderman, Alan B; Taylor, Herman A; Murray, Sarah S; Ferrucci, Luigi; Arking, Dan E; Evans, Michele K; Fox, Ervin R; Sotoodehnia, Nona; Heckbert, Susan R; Whitsel, Eric A; Newton-Cheh, Christopher

2012-12-01

Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval. First, individual estimates of African and European ancestry were inferred from genome-wide single-nucleotide polymorphism (SNP) data in 7 population-based cohorts of African Americans (n=12,097) and regressed on measured QT interval from ECGs. Second, imputation was performed for 2.8 million SNPs, and a genome-wide association study of QT interval was performed in 10 cohorts (n=13,105). There was no evidence of association between genetic ancestry and QT interval (P=0.94). Genome-wide significant associations (P<2.5 × 10(-8)) were identified with SNPs at 2 loci, upstream of the genes NOS1AP (rs12143842, P=2 × 10(-15)) and ATP1B1 (rs1320976, P=2 × 10(-10)). The most significant SNP in NOS1AP was the same as the strongest SNP previously associated with QT interval in individuals of European ancestry. Low probability values (P<10(-5)) were observed for SNPs at several other loci previously identified in genome-wide association studies in individuals of European ancestry, including KCNQ1, KCNH2, LITAF, and PLN. We observed no difference in duration of cardiac repolarization with global genetic indices of African American ancestry. In addition, our genome-wide association study extends the association of polymorphisms at several loci associated with repolarization in individuals of European ancestry to include individuals of African ancestry.

Quantitative evaluation of the requirements for the promotion as associate professor at German medical faculties.

PubMed

Sorg, Heiko; Knobloch, Karsten

2012-01-01

First quantitative evaluation of the requirements for the promotion as associate professor (AP) at German medical faculties. Analysis of the AP-regulations of German medical faculties according to a validated scoring system, which has been adapted to this study. The overall scoring for the AP-requirements at 35 German medical faculties was 13.5±0.6 of 20 possible scoring points (95% confidence interval 12.2-14.7). More than 88% of the AP-regulations demand sufficient performance in teaching and research with adequate scientific publication. Furthermore, 83% of the faculties expect an expert review of the candidate's performance. Conference presentations required as an assistant professor as well as the reduction of the minimum time as an assistant professor do only play minor roles. The requirements for assistant professors to get nominated as an associate professor at German medical faculties are high with an only small range. In detail, however, it can be seen that there still exists large heterogeneity, which hinders equal opportunities and career possibilities. These data might be used for the ongoing objective discussion.

A real time index of geomagnetic background noise for the MAD (Magnetic Anomaly Detection) frequency band

NASA Astrophysics Data System (ADS)

Bernardi, A.; Fraser-Smith, A. C.; Villard, O. G.

1985-02-01

An index of geomagnetic activity in the upper part of the ultra low frequency (ULF) range (less than 4.55 Hz) has been developed. This index will be referred to as the MA index (magnetic activity index). The MA index is prepared every half hour and is a measure of the strength of the geomagnetic activity in the Pc1-Pc3 pulsation frequency range during that half hour period. Activity in the individual Pc pulsation ranges can also be measured, if desired. The index is calculated from the running average of the full-wave rectified values of the band pass filtered geomagnetic signals and thus it provides a better indication of the magnitude of these band pass filtered magnetic pulsations than does the ap index, for example. Daily variations of the band pass filtered magnetic signals are also better captured by the MA index. To test this system we used analog tape recordings of wide-band geomagnetic signals. The indices for these tapes are presented in the form of plots, together with a comparison with the ap indices of the same time intervals. The MA index shows the daily variation of the geometric signals quite clearly during times when there is strong activity, i.e., when the ap index values are large. Because impulsive signals, such as lightning discharges, tend to be suppressed in the averaging process, the MA index is insensitive to impulsive noise. It is found that the time variation of the MA index is in general markedly different from the variation of the ap index for the same time intervals.

FAA Vertical Flight Bibliography, 1962 - 1994

DTIC Science & Technology

1994-08-01

high altitude conditions. A UH-1H aircraft will be used. This project is similar to the work documented in FAA/CT-TN87/40 "Heliport Approach and... work . TITLE: TEST PLAN FOR HELICOPTER VISUAL SEGMENT APPROACH LIGHTING SYSTEM (HALS) REPORT #: FAA/CT-TN88/19 NTIS: N/ A DATE: November 1988 AUTHORS...Hiering, Robert H. Ahlers) (NTIS: N/ A ) RD-64-4 State-of-the-Art Survey for Minimum Approach , Landing and Takeoff Intervals as Dictated by Wakes

Prediction of hypertensive crisis based on average, variability and approximate entropy of 24-h ambulatory blood pressure monitoring.

PubMed

Schoenenberger, A W; Erne, P; Ammann, S; Perrig, M; Bürgi, U; Stuck, A E

2008-01-01

Approximate entropy (ApEn) of blood pressure (BP) can be easily measured based on software analysing 24-h ambulatory BP monitoring (ABPM), but the clinical value of this measure is unknown. In a prospective study we investigated whether ApEn of BP predicts, in addition to average and variability of BP, the risk of hypertensive crisis. In 57 patients with known hypertension we measured ApEn, average and variability of systolic and diastolic BP based on 24-h ABPM. Eight of these fifty-seven patients developed hypertensive crisis during follow-up (mean follow-up duration 726 days). In bivariate regression analysis, ApEn of systolic BP (P<0.01), average of systolic BP (P=0.02) and average of diastolic BP (P=0.03) were significant predictors of hypertensive crisis. The incidence rate ratio of hypertensive crisis was 14.0 (95% confidence interval (CI) 1.8, 631.5; P<0.01) for high ApEn of systolic BP as compared to low values. In multivariable regression analysis, ApEn of systolic (P=0.01) and average of diastolic BP (P<0.01) were independent predictors of hypertensive crisis. A combination of these two measures had a positive predictive value of 75%, and a negative predictive value of 91%, respectively. ApEn, combined with other measures of 24-h ABPM, is a potentially powerful predictor of hypertensive crisis. If confirmed in independent samples, these findings have major clinical implications since measures predicting the risk of hypertensive crisis define patients requiring intensive follow-up and intensified therapy.

Heart failure with preserved ejection fraction: comparison of patients with and without angina pectoris (from the Duke Databank for Cardiovascular Disease).

PubMed

Mentz, Robert J; Broderick, Samuel; Shaw, Linda K; Fiuzat, Mona; O'Connor, Christopher M

2014-01-28

This study investigated the characteristics and outcomes of patients with heart failure with preserved ejection fraction (HFpEF) and angina pectoris (AP). AP is a predictor of adverse events in patients with heart failure with reduced EF. The implications of AP in HFpEF are unknown. We analyzed HFpEF patients (EF ≥50%) who underwent coronary angiography at Duke University Medical Center from 2000 through 2010 with and without AP in the previous 6 weeks. Time to first event was examined using Kaplan-Meier methods for the primary endpoint of death/myocardial infarction (MI)/revascularization/stroke (i.e., major adverse cardiac events [MACE]) and secondary endpoints of death/MI/revascularization, death/MI/stroke, death/MI, death, and cardiovascular death/cardiovascular hospitalization. In the Duke Databank, 3,517 patients met criteria for inclusion and 1,402 (40%) had AP. Those with AP were older with more comorbidities and prior revascularization compared with non-AP patients. AP patients more often received beta-blockers, angiotensin-converting enzyme inhibitors, nitrates, and statins (all p < 0.05). In unadjusted analysis, AP patients had increased MACE and death/MI/revascularization (both p < 0.001), lower rates of death and death/MI (both p < 0.05), and similar rates of death/MI/stroke and cardiovascular death/cardiovascular hospitalization (both p > 0.1). After multivariable adjustment, those with AP remained at increased risk for MACE (hazard ratio [HR]: 1.30, 95% confidence interval [CI]: 1.17 to 1.45) and death/MI/revascularization (HR: 1.29, 95% CI: 1.15 to 1.43), but they were at similar risk for other endpoints (p > 0.06). AP in HFpEF patients with a history of coronary artery disease is common despite medical therapy and is independently associated with increased MACE due to revascularization with similar risk of death, MI, and hospitalization. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

An Examination of Selected Geomagnetic Indices in Relation to the Sunspot Cycle

NASA Technical Reports Server (NTRS)

Wilson, Robert M.; Hathaway, David H.

2006-01-01

Previous studies have shown geomagnetic indices to be useful for providing early estimates for the size of the following sunspot cycle several years in advance. Examined this study are various precursor methods for predicting the minimum and maximum amplitude of the following sunspot cycle, these precursors based on the aa and Ap geomagnetic indices and the number of disturbed days (NDD), days when the daily Ap index equaled or exceeded 25. Also examined is the yearly peak of the daily Ap index (Apmax), the number of days when Ap greater than or equal to 100, cyclic averages of sunspot number R, aa, Ap, NDD, and the number of sudden storm commencements (NSSC), as well the cyclic sums of NDD and NSSC. The analysis yields 90-percent prediction intervals for both the minimum and maximum amplitudes for cycle 24, the next sunspot cycle. In terms of yearly averages, the best regressions give Rmin = 9.8+/-2.9 and Rmax = 153.8+/-24.7, equivalent to Rm = 8.8+/-2.8 and RM = 159+/-5.5, based on the 12-mo moving average (or smoothed monthly mean sunspot number). Hence, cycle 24 is expected to be above average in size, similar to cycles 21 and 22, producing more than 300 sudden storm commencements and more than 560 disturbed days, of which about 25 will be Ap greater than or equal to 100. On the basis of annual averages, the sunspot minimum year for cycle 24 will be either 2006 or 2007.

Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in l-arginine–Induced Acute Pancreatitis: An Experimental Study on Rats

PubMed Central

Cikman, Oztekin; Soylemez, Omer; Ozkan, Omer Faruk; Kiraz, Hasan Ali; Sayar, Ilyas; Ademoglu, Serkan; Taysi, Seyithan; Karaayvaz, Muammer

2015-01-01

The aim of this study was to investigate the possible protective role of antioxidant treatment with syringic acid (SA) on l-arginine–induced acute pancreatitis (AP) using biochemical and histopathologic approaches. A total of 30 rats were divided into 3 groups. The control group received normal saline intraperitoneally. The AP group was induced by 3.2 g/kg body weight l-arginine intraperitoneally, administered twice with an interval of 1 hour between administrations. The AP plus SA group, after having AP induced by 3.2 g/kg body weight l-arginine, was given SA (50 mg kg−1) in 2 parts within 24 hours. The rats were killed, and pancreatic tissue was removed and used in biochemical and histopathologic examinations. Compared with the control group, the mean pancreatic tissue total oxidant status level, oxidative stress index, and lipid hydroperoxide levels were significantly increased in the AP group, being 30.97 ± 7.13 (P < 0.05), 1.76 ± 0.34 (P < 0.0001), and 19.18 ± 4.91 (P < 0.01), respectively. However, mean total antioxidant status and sulfhydryl group levels were significantly decreased in the AP group compared with the control group, being 1.765 ± 0.21 (P < 0.0001) and 0.21 ± 0.04 (P < 0.0001), respectively. SA reduces oxidative stress markers and has antioxidant effects. It also augments antioxidant capacity in l-arginine–induced acute toxicity of pancreas in rats. PMID:26011211

Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in l-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats.

PubMed

Cikman, Oztekin; Soylemez, Omer; Ozkan, Omer Faruk; Kiraz, Hasan Ali; Sayar, Ilyas; Ademoglu, Serkan; Taysi, Seyithan; Karaayvaz, Muammer

2015-05-01

The aim of this study was to investigate the possible protective role of antioxidant treatment with syringic acid (SA) on l-arginine-induced acute pancreatitis (AP) using biochemical and histopathologic approaches. A total of 30 rats were divided into 3 groups. The control group received normal saline intraperitoneally. The AP group was induced by 3.2 g/kg body weight l-arginine intraperitoneally, administered twice with an interval of 1 hour between administrations. The AP plus SA group, after having AP induced by 3.2 g/kg body weight l-arginine, was given SA (50 mg kg(-1)) in 2 parts within 24 hours. The rats were killed, and pancreatic tissue was removed and used in biochemical and histopathologic examinations. Compared with the control group, the mean pancreatic tissue total oxidant status level, oxidative stress index, and lipid hydroperoxide levels were significantly increased in the AP group, being 30.97 ± 7.13 (P < 0.05), 1.76 ± 0.34 (P < 0.0001), and 19.18 ± 4.91 (P < 0.01), respectively. However, mean total antioxidant status and sulfhydryl group levels were significantly decreased in the AP group compared with the control group, being 1.765 ± 0.21 (P < 0.0001) and 0.21 ± 0.04 (P < 0.0001), respectively. SA reduces oxidative stress markers and has antioxidant effects. It also augments antioxidant capacity in l-arginine-induced acute toxicity of pancreas in rats.

Preventive Effect of Three Pomegranate (Punica granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice

PubMed Central

Minaiyan, Mohsen; Zolfaghari, Behzd; Taheri, Diana; Gomarian, Mahdi

2014-01-01

Background: Acute pancreatitis (AP) refers to afflicted inflammation of pancreas with unfavorable adverse effects and developed multiple organ failures. Unfortunately, there is not a certain therapeutic method for this disease. Oxidative stress has a serious role in the pathogenesis of AP. Thus, decreasing of oxidative stress may prevent induction and progression of AP. Punica granatum L. has been extensively used in traditional medicine and possesses various active biological elements. Due to antioxidant and anti-inflammatory properties of pomegranate, it could be considered as a good candidate alternative medicine with beneficial effects on AP. In this study, we decided to study the protective effect of three fractions of pomegranate seeds on cerulein-induced AP. Methods: AP was induced in male Syrian mice by five intraperitoneal (i.p.) injection of cerulein (50 μg/kg) with 1 h intervals. Treatments with pomegranate freeze-dried powder (PFDP) and hydroalcoholic pomegranate seeds extract (PSE) at doses of 125, 250, 500 mg/kg (i.p.) were started 30 min before pancreatitis induction. Pomegranate seed oil fraction (PSOF) was orally administered (50, 100, 200 μL/kg) and continued for 10 days. Pancreatic tissue was evaluated for histopathological parameters and pancreatic myeloperoxidase (MPO) activity as well as lipase and amylase levels were measured in plasma. Results: The higher doses of three fractions (250 and 500 mg/kg for PFDP and PSE and doses of 100, 200 μL/kg for PSOF) significantly reduced amylase and lipase activity in serum (at least P < 0.01), pancreatic MPO activity (P < 0.001), edema, leukocyte infiltration and vacuolization in comparison to the control group (P < 0.05). Conclusions: These results propose that pomegranate seeds fractions can prevent and/or treat the AP. PMID:24829726

Angina pectoris severity among coronary heart disease patients is associated with subsequent cognitive impairment.

PubMed

Weinstein, Galit; Goldbourt, Uri; Tanne, David

2015-01-01

The relationship between coronary heart disease (CHD) and cognitive function is not completely elucidated. We examined the association between severity of angina pectoris (AP) in mid-life and subsequent cognitive impairment among CHD patients. Severity of AP according to the Canadian Cardiovascular Society angina classification was assessed in a subgroup of people with chronic CHD, who previously participated in a secondary prevention trial. Cognitive performance was evaluated 15±3 years later, using a validated set of computerized cognitive tests (Neurotrax Computerized Cognitive Battery; computing index scores summarizing performance in each cognitive domain and a global cognitive score). We compared the risk of cognitive deficits in participants with AP class >2 to those with AP≤2, adjusting for vascular risk factors, common carotid-intima media thickness (CC-IMT), and presence of carotid plaques. Among 535 participants (mean age at baseline 57.9±6.6 y; 95% males), AP class >2 was associated with subsequent poorer performance on tests of memory and attention compared to those with AP class ≤2 (β=-4.3±1.8; P=0.016 and β=-3.6±1.7; P=0.029, respectively) and with a higher risk of having impairment in these domains [odds ratio (95% confidence interval)=1.83 (1.11-3.02); P=0.019 and 2.36 (1.34-4.16); P=0.003, for memory and attention, respectively]. These results were similar after controlling for vascular risk factors; however, the association of AP with memory domain attenuated after adjustment for CC-IMT or presence of carotid plaques. In people with preexisting CHD, severity of AP is associated with late-life poorer cognitive performance, independent of other vascular risk factors.

Adaptive threshold hunting for the effects of transcranial direct current stimulation on primary motor cortex inhibition.

PubMed

Mooney, Ronan A; Cirillo, John; Byblow, Winston D

2018-06-01

Primary motor cortex excitability can be modulated by anodal and cathodal transcranial direct current stimulation (tDCS). These neuromodulatory effects may, in part, be dependent on modulation within gamma-aminobutyric acid (GABA)-mediated inhibitory networks. GABAergic function can be quantified non-invasively using adaptive threshold hunting paired-pulse transcranial magnetic stimulation (TMS). The previous studies have used TMS with posterior-anterior (PA) induced current to assess tDCS effects on inhibition. However, TMS with anterior-posterior (AP) induced current in the brain provides a more robust measure of GABA-mediated inhibition. The aim of the present study was to assess the modulation of corticomotor excitability and inhibition after anodal and cathodal tDCS using TMS with PA- and AP-induced current. In 16 young adults (26 ± 1 years), we investigated the response to anodal, cathodal, and sham tDCS in a repeated-measures double-blinded crossover design. Adaptive threshold hunting paired-pulse TMS with PA- and AP-induced current was used to examine separate interneuronal populations within M1 and their influence on corticomotor excitability and short- and long-interval inhibition (SICI and LICI) for up to 60 min after tDCS. Unexpectedly, cathodal tDCS increased corticomotor excitability assessed with AP (P = 0.047) but not PA stimulation (P = 0.74). SICI AP was reduced after anodal tDCS compared with sham (P = 0.040). Pearson's correlations indicated that SICI AP and LICI AP modulation was associated with corticomotor excitability after anodal (P = 0.027) and cathodal tDCS (P = 0.042). The after-effects of tDCS on corticomotor excitability may depend on the direction of the TMS-induced current used to make assessments, and on modulation within GABA-mediated inhibitory circuits.

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats.

PubMed

Sadek, A S; Khattab, R T

2017-01-01

Acute pancreatitis (AP) is an inflammatory disease that has an increasing incidence worldwide. AP is associated with high morbidity and mortality rates ranging 15-40% in its severe form. Oxidative stress plays an important role in pancreatic acinar cell injury in case of AP. Melatonin (Mel) is proven to have both antioxidant and anti-inflammatory effects. The aim of the work was to investigate the protective role of Mel against L-arginine (L-arg)-induced AP in adult male albino rats. Thirty-six adult male albino rats were used in this study. Animals were divided into four groups; Control group (Group A; n = 6), Mel group (Group B; n = 6), L-arg group (Group C; n = 12) receiving two doses of L-arg injection with 1 h interval in-between, and L-arg+Mel group (Group D; n = 12) receiving Mel 1 h after each L-arg injection. 24 h after the second L-arg injection, the serum levels of amylase (AM), lipase (LP), interleukin-6 (IL-6) and tumour necrotic factor-alpha (TNF-α) were determined. Then, pancreatic specimens were processed for histological and immunohistochemical staining with vascular endothelial growth factor (VEGF) and the area percentage of VEGF and collagen content were measured by digital image analysis. Microscopic examination revealed that animals received L-arg only (Group C) showed loss of the pancreatic lobular architecture with marked fibrosis, acinar degeneration, inflammatory reaction and marked oedema with vascular congestion. Also, L-arg-induced AP caused a significant elevation of the serum levels of AM, LP, IL-6. All these histo-pathological and serological parameters were markedly improved by Mel administration. Melatonin exhibits strong therapeutic effects in the course of AP. Hence, the use of Mel as adjuvant treatment in AP is recommended.

A survey of georgia adult protective service staff: implications for older adult injury prevention and policy.

PubMed

Strasser, Sheryl M; Kerr, Judith; King, Patricia S; Payne, Brian; Beddington, Sarah; Pendrick, Danielle; Leyda, Elizabeth; McCarty, Frances

2011-07-01

The aging population is a rapidly growing demographic. Isolation and limited autonomy render many of the elderly vulnerable to abuse, neglect and exploitation. As the population grows, so does the need for Adult Protective Services (APS). This study was conducted to examine current knowledge of older adult protection laws in Georgia among APS staff and to identify training opportunities to better prepare the APS workforce in case detection and intervention. The Georgia State University Institute of Public Health faculty developed a primary survey in partnership with the Georgia Division of Aging Services' leadership to identify key training priority issues for APS caseworkers and investigators. A 47-item electronic questionnaire was delivered to all APS employees via work-issued email accounts. We conducted descriptive analyses, t-tests and chi-square analyses to determine APS employees' baseline knowledge of Georgia's elder abuse policies, laws and practices, as well as examine associations of age, ethnicity, and educational attainment with knowledge. We used a p-value of 0.05 and 95% confidence intervals to determine statistical significance of analyses performed. Ninety-two out of 175 APS staff responded to the survey (53% response rate). The majority of respondents were Caucasian (56%) women (92%). For over half the survey items, paired sample t-tests revealed significant differences between what APS staff reported as known and what APS staff members indicated they needed to know more about in terms of elder abuse and current policies. Chi-square tests revealed that non-Caucasians significantly preferred video conferencing as a training format (44% compared to 18%), [χ(2)(1) = 7.102, p < .008], whereas Caucasians preferred asynchronous online learning formats (55% compared to 28%) [χ(2)(1) =5.951, p < .015]. Results from this study provide the Georgia Division of Aging with insight into specific policy areas that are not well understood by APS staff. Soliciting input from intended trainees allows public health educators to tailor and improve training sessions. Trainee input may result in optimization of policy implementation, which may result in greater injury prevention and protection of older adults vulnerable to abuse, neglect and exploitation.

Air Pressure, Humidity and Stroke Occurrence: A Systematic Review and Meta-Analysis.

PubMed

Cao, Yongjun; Wang, Xia; Zheng, Danni; Robinson, Thompson; Hong, Daqing; Richtering, Sarah; Leong, Tzen Hugh; Salam, Abdul; Anderson, Craig; Hackett, Maree L

2016-07-05

An influence of climate upon stroke risk is biologically plausible and supported by epidemiological evidence. We aimed to determine whether air pressure (AP) and humidity are associated with hospital stroke admission. We searched MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and GEOBASE, from inception to 16 October 2015 to identify relevant population-based observational studies. Where possible, data were pooled for meta-analysis with odds ratios (OR) and corresponding 95% confidence intervals (CI) by means of the random-effect method. We included 11 studies with a total of 314,385 patients. The effect of AP was varied across studies for ischemic stroke (IS) and subarachnoid haemorrhage (SAH). Pooled ORs (95%CI) associated with 1 hPa increase in AP for the risk of IS, intracerebral hemorrhage (ICH) and SAH were 1.00 (0.99-1.01), 1.01 (0.99-1.02) and 1.02 (0.97-1.07) respectively. The pooled ORs (95%CI) associated with 1 percent increase in humidity for the risk of IS and ICH were 1.00 (1.00-1.01) and 1.00 (0.99-1.01) respectively. This review shows that there is no evidence of a relationship between AP or humidity and the occurrence of hospital admission for stroke. Further research is needed to clarify the extent and nature of any relationship between AP, humidity and stroke in different geographical areas.

Toxic effects of antiparasitic pesticides used by the salmon industry in the marine amphipod Monocorophium insidiosum.

PubMed

Tucca, Felipe; Díaz-Jaramillo, Mauricio; Cruz, Gabriel; Silva, Jeannette; Bay-Schmith, Enrique; Chiang, Gustavo; Barra, Ricardo

2014-08-01

The use of antiparasitic pesticides (APs) has been widely required by the salmon industry to treat diseases. The direct emission of chemicals in the seawater has produced uncertainty about the potential effects on nontarget organisms, such as crustaceans. The aim of this study was to assess the toxicity of three APs used by the salmon farm industry, such as emamectin benzoate (EB), cypermethrin (CP), and deltamethrin (DE), in the amphipod Monocorophium insidiosum during 10 days through whole-sediment bioassay tests. Lethal concentration by 50 % (LC50-10d) and biochemical responses, such as glutathione S-transferase (GST) and thiobarbituric acid reactive substances (TBARS), were measured as exposure and effects end points, respectively. Acute assays for DE (7.8 μg kg(-1), confidence interval, CI95% 5-11) and CP (57 μg kg(-1), CI95% 41-77) showed more mortality than EB (890 μg kg(-1), CI95% 672-1,171). In this study, it was possible to observe sublethal responses in amphipods after 2 days of exposure to APs. Significant induction in GST and TBARS (p < 0.05) were measured for CP and EB. Lower DE concentrations showed no significant biochemical responses. M. insidiosum was sensitive to AP concentrations at μg kg(-1) in sediments. This information would allow considering the possible consequences of detected concentrations for APs in areas with intensive salmon farming activity.

Humus characteristics and seasonal changes of soil arthropod communities in a natural sessile oak (Quercus petraea L.) stand and adjacent Austrian pine (Pinus nigra Arnold) plantation.

PubMed

Cakir, Meric; Makineci, Ender

2013-11-01

In order to assess the effects of conversion of natural stands into plantations, soil invertebrate micro- and macroarthropod communities were evaluated for their abundance and richness in a sessile oak (SO; Quercus petraea L.) stand and adjacent Austrian pine (AP; Pinus nigra Arnold) plantation. Sites were sampled four times a year in 3-month intervals from May 2009 to February 2010. Humus characteristics such as total mass; carbon, lignin, and cellulose contents; and C/N ratio were significantly different between SO and AP. Statistically significant differences were detected on soil pH, carbon and nitrogen contents, and electrical conductivity between the two sites. The number of microarthropods was higher in AP than in the SO site. The annual mean abundance values of microarthropods in a square meter were 67,763 in AP and 50,542 in SO, and the annual mean abundance values of macroarthropods were 921 m(-2) in AP and 427 m(-2) in SO. Among the soil microarthropods, Acari and Collembola were the dominant groups. Shannon's diversity index was more affected by evenness than species number despite the species diversity (H') of soil arthropods being generally higher in the SO stand. The abundance of microarthropods showed clear seasonal trends depending upon the humidity of the soil.

Characterizing the complexity of spontaneous motor unit patterns of amyotrophic lateral sclerosis using approximate entropy

NASA Astrophysics Data System (ADS)

Zhou, Ping; Barkhaus, Paul E.; Zhang, Xu; Zev Rymer, William

2011-10-01

This paper presents a novel application of the approximate entropy (ApEn) measurement for characterizing spontaneous motor unit activity of amyotrophic lateral sclerosis (ALS) patients. High-density surface electromyography (EMG) was used to record spontaneous motor unit activity bilaterally from the thenar muscles of nine ALS subjects. Three distinct patterns of spontaneous motor unit activity (sporadic spikes, tonic spikes and high-frequency repetitive spikes) were observed. For each pattern, complexity was characterized by calculating the ApEn values of the representative signal segments. A sliding window over each segment was also introduced to quantify the dynamic changes in complexity for the different spontaneous motor unit patterns. We found that the ApEn values for the sporadic spikes were the highest, while those of the high-frequency repetitive spikes were the lowest. There is a significant difference in mean ApEn values between two arbitrary groups of the three spontaneous motor unit patterns (P < 0.001). The dynamic ApEn curve from the sliding window analysis is capable of tracking variations in EMG activity, thus providing a vivid, distinctive description for different patterns of spontaneous motor unit action potentials in terms of their complexity. These findings expand the existing knowledge of spontaneous motor unit activity in ALS beyond what was previously obtained using conventional linear methods such as firing rate or inter-spike interval statistics.

Factors That Affect Disease Progression After First Attack of Acute Pancreatitis.

PubMed

Bertilsson, Sara; Swärd, Per; Kalaitzakis, Evangelos

2015-09-01

Little is known about recurrence of pancreatitis after an initial episode, and little is known about how the disease progresses or what factors affect progression. We performed a population-based study of patients with acute pancreatitis (AP) to determine their outcomes and associated factors. We performed a retrospective study of patients with first-time AP from 2003 through 2012 in a well-defined area of Sweden. Data were collected from medical records on disease etiology, severity (according to the Atlanta classification), recurrence of AP, subsequent chronic pancreatitis, and mortality. Patients were followed up for a median time of 4.6 years, until death or the end of 2013. We identified 1457 patients with first-time AP (48% biliary disease, 17% alcohol-associated, 9.9% severe); 23% of patients had 1 or more recurrences. Risk for recurrence was significantly higher among smokers (hazard ratio [HR], 1.42; 95% confidence interval [CI], 1.03-1.95; P = .03), patients with alcohol-associated AP (HR, 1.58; 95% CI, 1.25-2.23; P < .01), after organ failure (HR, 1.46; 95% CI 1.05-2.03; P = .02), and in patients with systemic complications (HR, 1.88; 95% CI, 1.27-2.79; P < .01) or local complications (HR, 1.66; 95% CI, 1.22-2.27; P < .01). AP of all etiologies progressed to chronic pancreatitis, although alcohol-associated AP progressed most frequently (2.8/100 patient-years). Patients with recurrent AP were at the highest risk for chronic pancreatitis (HR, 6.74; 95% CI, 4.02-11.3; P < .01), followed by alcohol-associated AP (HR, 3.10; 95% CI, 2.05-5.87; P < .01), smoking (HR, 2.26; 95% CI, 1.12-4.58; P = .02), systemic complications (HR, 1.37; 95% CI, 1.06-4.62; P = .03), and peripancreatic necrosis (HR, 2.74; 95% CI, 1.7-4.43; P < .01). In-hospital mortality was 2.8%, and independently associated only with organ failure (odds ratio, 71.17; 95% CI, 21.14-239.60; P < .01). Fifty-three percent of patients who died during disease recurrence had biliary AP; a higher percentage of these patients died upon first recurrence (5.9%) than upon first attack of AP (2%; P = .01). The severity of first-time AP, smoking, and alcohol abuse are related to recurrence and subsequent chronic pancreatitis. Recurrence increases the risk for progression to chronic pancreatitis. Most patients who die upon disease recurrence have biliary AP. Copyright © 2015. Published by Elsevier Inc.

Thermal and photo-stability of the antioxidant potential of Spirulina platensis powder.

PubMed

Colla, L M; Bertol, C D; Ferreira, D J; Bavaresco, J; Costa, J A V; Bertolin, T E

2017-01-01

This work aimed to evaluate the thermal and photo stability of the antioxidant potential (AP) of the Spirulina platensis biomass. Thermal stability was established at 25ºC, 40ºC and 50ºC for 60 days, in the dark, protected from light. Photo stability was evaluated using UV (15 W, λ = 265 nm) and fluorescent (20 W, 0.16 A, power factor FP > 0.5, 50/60 Hz, 60 lm/w, 1200 lm) light for 90 days in capsules, glass and Petri dishes, at room temperature. The AP of the biomass in these conditions was determined at intervals (every 7 and 30 days in the studies of thermal and photo stability, respectively) using the induction of the oxidation of a lipid system by heat and aeration. In this lipid system, the biomass submitted to degradation was used as an antioxidant. The kinetics of the reaction was determined by the Arrhenius method. Thermal degradation was found to follow zero order kinetics, whereas photo degradation followed first order kinetics. The AP decreased 50% after 50 days at 25°C. At 40°C and 50°C, the AP decreased more than 50% after 35 and 21 days of exposition, respectively. The decrease of the AP of Spirulina was more sensible to UV and fluorescence light. After 30 days of exposition, the AP decreased more than 50% in all storage conditions tested. The antioxidant potential of Spirulina platensis is easily degraded when the biomass is exposed to heat and light, indicating the need for care to be taken in its storage.

Approximate entropy: a new evaluation approach of mental workload under multitask conditions

NASA Astrophysics Data System (ADS)

Yao, Lei; Li, Xiaoling; Wang, Wei; Dong, Yuanzhe; Jiang, Ying

2014-04-01

There are numerous instruments and an abundance of complex information in the traditional cockpit display-control system, and pilots require a long time to familiarize themselves with the cockpit interface. This can cause accidents when they cope with emergency events, suggesting that it is necessary to evaluate pilot cognitive workload. In order to establish a simplified method to evaluate cognitive workload under a multitask condition. We designed a series of experiments involving different instrument panels and collected electroencephalograms (EEG) from 10 healthy volunteers. The data were classified and analyzed with an approximate entropy (ApEn) signal processing. ApEn increased with increasing experiment difficulty, suggesting that it can be used to evaluate cognitive workload. Our results demonstrate that ApEn can be used as an evaluation criteria of cognitive workload and has good specificity and sensitivity. Moreover, we determined an empirical formula to assess the cognitive workload interval, which can simplify cognitive workload evaluation under multitask conditions.

Ectopic beats in approximate entropy and sample entropy-based HRV assessment

NASA Astrophysics Data System (ADS)

Singh, Butta; Singh, Dilbag; Jaryal, A. K.; Deepak, K. K.

2012-05-01

Approximate entropy (ApEn) and sample entropy (SampEn) are the promising techniques for extracting complex characteristics of cardiovascular variability. Ectopic beats, originating from other than the normal site, are the artefacts contributing a serious limitation to heart rate variability (HRV) analysis. The approaches like deletion and interpolation are currently in use to eliminate the bias produced by ectopic beats. In this study, normal R-R interval time series of 10 healthy and 10 acute myocardial infarction (AMI) patients were analysed by inserting artificial ectopic beats. Then the effects of ectopic beats editing by deletion, degree-zero and degree-one interpolation on ApEn and SampEn have been assessed. Ectopic beats addition (even 2%) led to reduced complexity, resulting in decreased ApEn and SampEn of both healthy and AMI patient data. This reduction has been found to be dependent on level of ectopic beats. Editing of ectopic beats by interpolation degree-one method is found to be superior to other methods.

Ethnic and geographic variations in the incidence of pancreatitis and post-pancreatitis diabetes mellitus in New Zealand: a nationwide population-based study.

PubMed

Pendharkar, Sayali A; Mathew, Juby; Zhao, Jinfeng; Windsor, John A; Exeter, Daniel J; Petrov, Maxim S

2017-02-17

To determine the incidence of acute pancreatitis (AP), chronic pancreatitis (CP), and post-pancreatitis diabetes mellitus (DP) in New Zealand, and the effect of ethnic and geographic variations. Data were collected from all district health boards in New Zealand by the Ministry of Health (Manatū Hauora). Diagnosis of AP, CP and DP was determined by the International Classification of Diseases-10 codes. Incidence rates per 100,000 population per year were calculated using incident AP, CP and DP cases as the numerator, and the adult resident population of New Zealand as the denominator. Poisson distribution was used to estimate 95% confidence intervals. The district health board domicile codes and corresponding incidence rates were used to map geographical variations for AP, CP and DP. On average, 2,072 new cases of AP, CP and DP were diagnosed in New Zealand every year. The crude incidence of AP was 58.42 [57.55, 59.30], CP - 3.97 [3.74, 4.20], and DP - 7.95 [7.62, 8.27] per 100,000 population per year. Māori had the highest incidence of AP (95.21 [91.74, 98.68] per 100,000 population per year), CP (6.27 [5.37, 7.16] per 100,000 population per year), and DP (18.23 [16.71, 19.76] per 100,000 population per year). Incidence of AP and DP was at least 1.8 and 2.6 times higher in Māori than New Zealand Europeans in every age group, and incidence of DP was at least 1.9 times higher in Pacific people than New Zealand Europeans in every age group. Auckland/Northland had the highest incidence of AP (135.25 [134.82, 135.68] per 100,000 population), and CP (9.03 [8.60, 9.46] per 100,000 population), while Lakes/Waikato had the highest incidence of DP (20.64 [20.21, 21.07] per 100,000 population) in New Zealand. New Zealanders have a very high incidence rate of AP, with Māori having the highest reported incidence of AP worldwide. There is a significant geographic variation in incidence of pancreatic diseases, with the Upper North Island having the highest incidence rates of AP, CP and DP in the country. Future high-quality studies are required to understand the mechanisms of pancreatitis and DP in order to develop preventive and therapeutic strategies that would benefit New Zealanders in general and Māori in particular.

Perceptions Regarding Importance and Skill at Policy Development Among Public Health Staff

PubMed Central

Castrucci, Brian C.; Leider, Jonathon P.; Sellers, Katie

2015-01-01

Context: Policy development is recognized as a core function of public health and a core competency in formal public health education. However, relatively little is known nationally about worker perceptions and competencies related to policy development in the governmental public health workforce. Objective: To characterize perceived importance and presence or absence of competency gaps related to policy development. Design: As part of the Public Health Workforce Interests and Needs Survey (PH WINS), a nationally representative stratified sample of permanently employed state health agency (SHA) central office staff was created. Descriptive and inferential analyses examined correlates of perceived importance and competency gaps related to policy development. Setting and Participants: Permanently employed central office employees of SHAs. Main Outcome Measure: Analyses focus on 2 self-reported measures of perceived importance and ability related to policy development skills, as well as awareness and perceptions regarding Health in All Policies (HiAP). Results: Seventy-two percent of SHA central office staff (95% confidence interval, 71-73) indicated “influencing policy development” was somewhat or very important to their day-to-day work. Among that group, 35% (95% confidence interval, 34-36) reported that they were unable to perform this or they considered themselves to be a beginner at this skill. Approximately three-fourths of staff indicated “understanding the relationship between a new policy and many types of public health problems” was somewhat or very important, and 30% of those who did said they were unable to perform this skill or were a beginner at it. Nationally, one-half of staff have not heard of HiAP. Among those who have, 86% indicated it was somewhat or very important to public health, and 41% reported they would like to see more emphasis on HiAP. Conclusions: Workforce development, both formal education and on-the-job training, may benefit from placing a greater emphasis on the development of policy skills. HiAP is an important approach to policy development. PMID:26422484

Nonpharmacologic treatment of functional abdominal pain disorders: a systematic review.

PubMed

Rutten, Juliette M T M; Korterink, Judith J; Venmans, Leonie M A J; Benninga, Marc A; Tabbers, Merit M

2015-03-01

Various nonpharmacologic treatments are available for pediatric abdominal pain-related functional gastrointestinal disorders (AP-FGIDs). Data on efficacy and safety are scarce. The goal of this study was to summarize the evidence regarding nonpharmacologic interventions for pediatric AP-FGIDs: lifestyle interventions, dietary interventions, behavioral interventions, prebiotics and probiotics, and alternative medicine. Searches were conducted of the Medline and Cochrane Library databases. Systematic reviews and randomized controlled trials (RCTs) concerning nonpharmacologic therapies in children (aged 3-18 years) with AP-FGIDs were included, and data were extracted on participants, interventions, and outcomes. The quality of evidence was assessed by using the GRADE approach. Twenty-four RCTs were found that included 1390 children. Significant improvement of abdominal pain was reported after hypnotherapy compared with standard care/wait-list approaches and after cognitive behavioral therapy compared with a variety of control treatments/wait-list approaches. Written self-disclosure improved pain frequency at the 6-month follow-up only. Compared with placebo, Lactobacillus rhamnosus GG (LGG) and VSL#3 were associated with significantly more treatment responders (LGG relative risk: 1.31 [95% confidence interval: 1.08 to 1.59]; VSL#3: P < .05). Guar gum significantly improved irritable bowel syndrome symptom frequency; however, no effect was found for other fiber supplements (relative risk: 1.17 [95% confidence interval: 0.75 to 1.81]) or a lactose-free diet. Functional disability was not significantly decreased after yoga compared with a wait-list approach. No studies were found concerning lifestyle interventions; gluten-, histamine-, or carbonic acid-free diets; fluid intake; or prebiotics. No serious adverse effects were reported. The quality of evidence was found to be very low to moderate. Although high-quality studies are lacking, some evidence shows efficacy of hypnotherapy, cognitive behavioral therapy, and probiotics (LGG and VSL#3) in pediatric AP-FGIDs. Data on fiber supplements are inconclusive. Copyright © 2015 by the American Academy of Pediatrics.

Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Han; Sun, Yan Ping; Li, Yang

2010-03-05

Molecular hydrogen, which reacts with the hydroxyl radical, has been considered as a novel antioxidant. Here, we evaluated the protective effects of hydrogen-rich saline on the L-arginine (L-Arg)-induced acute pancreatitis (AP). AP was induced in Sprague-Dawley rats by giving two intraperitoneal injections of L-Arg, each at concentrations of 250 mg/100 g body weight, with an interval of 1 h. Hydrogen-rich saline (>0.6 mM, 6 ml/kg) or saline (6 ml/kg) was administered, respectively, via tail vein 15 min after each L-Arg administration. Severity of AP was assessed by analysis of serum amylase activity, pancreatic water content and histology. Samples of pancreasmore » were taken for measuring malondialdehyde and myeloperoxidase. Apoptosis in pancreatic acinar cell was determined with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling technique (TUNEL). Expression of proliferating cell nuclear antigen (PCNA) and nuclear factor kappa B (NF-{kappa}B) were detected with immunohistochemistry. Hydrogen-rich saline treatment significantly attenuated the severity of L-Arg-induced AP by ameliorating the increased serum amylase activity, inhibiting neutrophil infiltration, lipid oxidation and pancreatic tissue edema. Moreover, hydrogen-rich saline treatment could promote acinar cell proliferation, inhibit apoptosis and NF-{kappa}B activation. These results indicate that hydrogen treatment has a protective effect against AP, and the effect is possibly due to its ability to inhibit oxidative stress, apoptosis, NF-{kappa}B activation and to promote acinar cell proliferation.« less

Air Pressure, Humidity and Stroke Occurrence: A Systematic Review and Meta-Analysis

PubMed Central

Cao, Yongjun; Wang, Xia; Zheng, Danni; Robinson, Thompson; Hong, Daqing; Richtering, Sarah; Leong, Tzen Hugh; Salam, Abdul; Anderson, Craig; Hackett, Maree L.

2016-01-01

Background/Aims: An influence of climate upon stroke risk is biologically plausible and supported by epidemiological evidence. We aimed to determine whether air pressure (AP) and humidity are associated with hospital stroke admission. Methods: We searched MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and GEOBASE, from inception to 16 October 2015 to identify relevant population-based observational studies. Where possible, data were pooled for meta-analysis with odds ratios (OR) and corresponding 95% confidence intervals (CI) by means of the random-effect method. Results: We included 11 studies with a total of 314,385 patients. The effect of AP was varied across studies for ischemic stroke (IS) and subarachnoid haemorrhage (SAH). Pooled ORs (95%CI) associated with 1 hPa increase in AP for the risk of IS, intracerebral hemorrhage (ICH) and SAH were 1.00 (0.99–1.01), 1.01 (0.99–1.02) and 1.02 (0.97–1.07) respectively. The pooled ORs (95%CI) associated with 1 percent increase in humidity for the risk of IS and ICH were 1.00 (1.00–1.01) and 1.00 (0.99–1.01) respectively. Conclusion: This review shows that there is no evidence of a relationship between AP or humidity and the occurrence of hospital admission for stroke. Further research is needed to clarify the extent and nature of any relationship between AP, humidity and stroke in different geographical areas. PMID:27399733

C-Reactive Protein at 24 Hours after Hospital Admission may have Relevant Prognostic Accuracy in Acute Pancreatitis: A Retrospective Cohort Study.

PubMed

Cardoso, Filipe S; Ricardo, Leonel B; Oliveira, Ana M; Horta, David V; Papoila, Ana L; Deus, João R; Canena, Jorge

2015-01-01

C-reactive protein (CRP) and Bedside Index for Severity in Acute Pancreatitis (BISAP) have been used in early risk assessment of patients with AP. We evaluated prognostic accuracy of CRP at 24 hours after hospital admission (CRP24) for in-hospital mortality (IM) in AP individually and with BISAP. This retrospective cohort study included 134 patients with AP from a Portuguese hospital in 2009-2010. Prognostic accuracy assessment used area under receiver-operating characteristic curve (AUC), continuous net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Thirteen percent of patients had severe AP, 26% developed pancreatic necrosis, and 7% died during index hospital stay. AUCs for CRP24 and BISAP individually were 0.80 (95% confidence interval (CI) 0.65-0.95) and 0.77 (95% CI 0.59-0.95), respectively. No patients with CRP24 <60 mg/l died ( P  = 0.027; negative predictive value 100% (95% CI 92.3-100%)). AUC for BISAP plus CRP24 was 0.81 (95% CI 0.65-0.97). Change in NRI nonevents (42.4%; 95% CI, 24.9-59.9%) resulted in positive overall NRI (31.3%; 95% CI, -36.4% to 98.9%), but IDI nonevents was negligible (0.004; 95% CI, -0.007 to 0.014). CRP24 revealed good prognostic accuracy for IM in AP; its main role may be the selection of lowest risk patients.

Green Bank Telescope Observations of HI in the circumgalactic medium of M31

NASA Astrophysics Data System (ADS)

Denny, Lucas; Early, Laura; Berg, Michelle; Howk, Chris; Lehner, Nicolas; Lockman, Felix; wotta, Christopher

2018-01-01

The nearby spiral galaxy M31 contains an extensive gaseous circumgalactic medium (CGM) that is being studied in project AMIGA, a large HST program to obtain UV spectroscopy of the CGM in absorption against background AGN. As part of this project, sensitive HI 21cm emission observations were made using the Robert C. Byrd Green Bank Telescope (GBT) toward 48 AGN at impact parameters between 25 kpc and 340 kpc. No emission was detected to a 5-sigma limit on log(NHI) of 17.6 cm-2 (Howk et al 2017, ApJ, 846, 141). We now report on a search for HI emission in 1x1 degree fields around 8 of the AGN to 5-sigma limits on log(NHI) of 17.9 cm-2. The new observations cover ~10 times the area of the M31 CGM covered by the Howk et al pointings, though at somewhat reduced sensitivity. Again, no HI emission was detected with the exception of the "Davies Cloud", a high-velocity cloud of M31 that has been known for some time. We will discuss the absence of significant HI emission in the context of the COS-Halos study of 44 galaxies at z~0.2, and how this finding may relate to the existence of HI clouds between M31 and M33 (Wolfe et al. 2016, ApJ, 816, 81).The GBT is a facility of the National Science Foundation, operated under a cooperative agreement by Associated Universities, Inc.

Aerophagia in adolescents is associated with exposure to adverse life events and psychological maladjustment.

PubMed

Rajindrajith, S; Hettige, S; Gulegoda, I; Jayawickrama, N; De Silva, S C; Samarakoon, H K; de Silva, R L; Abeyagunawardena, S; Devanarayana, N M

2018-03-01

Aerophagia is a common childhood functional gastrointestinal disorder. We studied the association between adverse life events (ALEs), psychological maladjustment, somatization, and aerophagia (AP) in adolescents. We also assessed the impact of AP on their health-related quality of life (HRQoL). A cross-sectional survey was conducted on 2500 subjects of 13-18 years in 8 randomly selected schools in Sri Lanka. Translated, validated, and self-administered questionnaires were used to collect data. Aerophagia was diagnosed using Rome III criteria. A total of 2453 questionnaires were analyzed (males 1200 [48.9%], mean age 14.8 years, SD 1.6 years). Of them, 371 adolescents had AP (15.1%). Aerophagia was associated with exposure to physical abuse (20.4% vs. 12.7% in controls, P < .0001), emotional abuse (20.3% vs. 8.2% in controls, P < .0001), and other ALEs (22% vs. 10.2% in controls, P < .001). One hundred and ninety (51.2%) adolescents with AP and 775 (37.2%) controls had a personality score above the international cutoff value of 105, indicating psychological maladjustment (odds ratio 1.77, 95% confidence interval 1.42-2.21, P < .0001). Those with AP had higher somatization (16.4 vs. 8.9) and lower overall HRQoL scores (77.0 vs. 85.1, P < .0001). HRQoL scores of adolescents with AP were lower in all domains, namely, physical (80.6 vs. 86.9), emotional (69.1 vs. 80.3), social (83.8 vs. 90.5), and school (72.6 vs. 82.5) functioning (P < .0001). Aerophagia was associated with exposure to ALEs and psychological maladjustment. Affected teenagers suffer from more somatic symptoms and has a poor HRQoL. © 2017 John Wiley & Sons Ltd.

Comment on "The Predicted Size of Cycle 23 Based on the Inferred three-cycle Quasiperiodicity of the Planetary Index Ap"

NASA Technical Reports Server (NTRS)

Wilson, Robert M.; Hathaway, David H.

1999-01-01

Recently, Ahluwalia reviewed the solar and geomagnetic data for the last 6 decades and remarked that these data "indicate the existence of a three-solar-activity-cycle quasiperiodicity in them." Furthermore, on the basis of this inferred quasiperiodicity, he asserted that cycle 23 represents the initial cycle in a new three-cycle string, implying that it "will be more modest (a la cycle 17) with an annual mean sunspot number count of 119.3 +/- 30 at the maximum", a prediction that is considerably below the consensus prediction of 160 +/- 30 by Joselin et al. and of similar predictions by others based on a variety of predictive techniques. Several major sticking points of Ahluwalia's presentation, however, must be readdressed, and these issues form the basis of this comment. First, Ahluwalia appears to have based his analysis on a data set of Ap index values that is erroneous. For example, he depicts for the interval of 1932-1997 the variation of the Ap index in terms of annual averages, contrasting them against annual averages of sunspot number (SSN), and he lists for cycles 17-23 the minimum and maximum value of each, as well as the years in which they occur and a quantity which he calls "Amplitude" (defined as the numeric difference between the maximum and minimum values). In particular, he identifies the minimum Ap index (i.e., the minimum value of the Ap index in the vicinity of sunspot cycle minimum, which usually occurs in the year following sunspot minimum and which will be called hereafter, simply, Ap min) and the year in which it occur for cycles 17 - 23 respectively.

Nonspecific abdominal pain in pediatric primary care: evaluation and outcomes.

PubMed

Wallis, Elizabeth M; Fiks, Alexander G

2015-01-01

To describe the characteristics of children with nonspecific abdominal pain (AP) in primary care, their evaluation, and their outcomes. Between 2007 and 2009, a retrospective cohort of children from 5 primary care practices was followed from an index visit with AP until a well-child visit 6 to 24 months later (outcome visit). Using International Classification of Disease, 9th Revision (ICD-9), codes and chart review, we identified afebrile children between 4 and 12 years old with AP. Use of diagnostic testing was assessed. Multivariable logistic regression was used to model the association of index visit clinical and demographic variables with persistent pain at the outcome visit, and receipt of a specific diagnosis. Three hundred seventy-five children presented with AP, representing 1% of the total population of 4- to 12-year-olds during the study period. Eighteen percent of children had persistent pain, and 70% of the study cohort never received a specific diagnosis for their pain. Seventeen percent and 14% of children had laboratory and radiology testing at the index visit, respectively. Only 3% of laboratory evaluations helped to yield a diagnosis. Among variables considered, only preceding pain of more than 7 days at the index visit was associated with persistent pain (odds ratio 2.15, 95% confidence interval 1.19-3.89). None of the variables considered was associated with receiving a specific diagnosis. Most children with AP do not receive a diagnosis, many have persistent pain, and very few receive a functional AP diagnosis. Results support limited use of diagnostic testing and conservative management consistent with national policy statements. Copyright © 2015 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

Associations of long-term exposure to air pollution and road traffic noise with cognitive function-An analysis of effect measure modification.

PubMed

Tzivian, Lilian; Jokisch, Martha; Winkler, Angela; Weimar, Christian; Hennig, Frauke; Sugiri, Dorothea; Soppa, Vanessa J; Dragano, Nico; Erbel, Raimund; Jöckel, Karl-Heinz; Moebus, Susanne; Hoffmann, Barbara

2017-06-01

Adverse effects of traffic-related air pollution (AP) and noise on cognitive functions have been proposed, but little is known about their interactions and the combined effect of co-exposure. Cognitive assessment was completed by 4086 participants of the population-based Heinz Nixdorf Recall cohort study using five neuropsychological subtests and an additively calculated global cognitive score (GCS). We assessed long-term residential concentrations for size-fractioned particulate matter (PM) and nitrogen oxides with land use regression. Road traffic noise (weighted 24-h (L DEN ) and night-time (L NIGHT ) means) was assessed according to the EU directive 2002/49/EC. Linear regression models adjusted for individual-level characteristics were calculated to estimate effect modification of associations between AP and noise with cognitive function. We used multiplicative interaction terms and categories of single or double high exposure, dichotomizing the potential effect modifier at the median (AP) or at an a priori defined threshold (road traffic noise). In fully adjusted models, high noise exposure increased the association of AP with cognitive function. For example, for an interquartile range increase of PM 2.5 (IQR 1.43), association s with GCS were: estimate (β)=-0.16 [95% confidence interval: -0.33; 0.01] and β=-0.48 [-0.72; -0.23] for low and high L DEN , respectively. The association of noise with GCS was restricted to highly AP-exposed participants. We observed stronger negative associations in those participants with double exposure compared to the addition of effect estimates of each single exposure. Our study suggests that AP and road traffic noise might act synergistically on cognitive function in adults. Copyright © 2017 Elsevier Ltd. All rights reserved.

Short-term action potential memory and electrical restitution: A cellular computational study on the stability of cardiac repolarization under dynamic pacing

PubMed Central

2018-01-01

Electrical restitution (ER) is a major determinant of repolarization stability and, under fast pacing rate, it reveals memory properties of the cardiac action potential (AP), whose dynamics have never been fully elucidated, nor their ionic mechanisms. Previous studies have looked at ER mainly in terms of changes in AP duration (APD) when the preceding diastolic interval (DI) changes and described dynamic conditions where this relationship shows hysteresis which, in turn, has been proposed as a marker of short-term AP memory and repolarization stability. By means of numerical simulations of a non-propagated human ventricular AP, we show here that measuring ER as APD versus the preceding cycle length (CL) provides additional information on repolarization dynamics which is not contained in the companion formulation. We focus particularly on fast pacing rate conditions with a beat-to-beat variable CL, where memory properties emerge from APD vs CL and not from APD vs DI and should thus be stored in APD and not in DI. We provide an ion-currents characterization of such conditions under periodic and random CL variability, and show that the memory stored in APD plays a stabilizing role on AP repolarization under pacing rate perturbations. The gating kinetics of L-type calcium current seems to be the main determinant of this safety mechanism. We also show that, at fast pacing rate and under otherwise identical pacing conditions, a periodically beat-to-beat changing CL is more effective than a random one in stabilizing repolarization. In summary, we propose a novel view of short-term AP memory, differentially stored between systole and diastole, which opens a number of methodological and theoretical implications for the understanding of arrhythmia development. PMID:29494628

Older adults prioritize postural stability in the anterior-posterior direction to regain balance following volitional lateral step.

PubMed

Porter, Shaun; Nantel, Julie

2015-02-01

Postural control in the medial-lateral (ML) direction is of particular interest regarding the assessment of changes in postural control, as it is highly related to the risk of falling. To determine the postural strategies used to regain balance following a voluntary lateral step and compare these strategies between young and older adults. Sixteen older adults (60-90 years) and 14 young adults (20-40 years) were asked to stand quietly for 30s, walk in place and then take a lateral step and stand quietly (30s). Balance Post was divided into 10s intervals. Center of pressure displacement (CoP) and velocity (VCoP) in the anterio-posterior (AP) and ML directions were analyzed. In both groups, CoP and VCoP in AP and ML increased in Post1 compared to Pre (P<0.001). Dissimilar to young adults, VCoP-Post2, Post3 ML were larger than Pre (P=0.01) in older adults. Age correlated with all VCoP (Pre and Post) in both ML (P<0.05) and AP directions (P<0.01). Dissimilar to young adults, older adults use different postural strategies in ML and AP directions and prioritized postural stability in the AP direction to recover balance after completing a lateral step. In the ML direction, older adults took up to 30s to regain balance. Considering that age was related to larger CoP displacement and velocity, the AP strategy to recover postural balance following a lateral step could become less efficient as older adults age and therefore increasing the risk of falls. Copyright © 2015 Elsevier B.V. All rights reserved.

Impact of Antithrombotic Regimen on Mortality, Ischemic, and Bleeding Outcomes after Transcatheter Aortic Valve Replacement.

PubMed

Varshney, Anubodh; Watson, Ryan A; Noll, Andrew; Im, KyungAh; Rossi, Jeffrey; Shah, Pinak; Giugliano, Robert P

2018-05-19

Optimal antithrombotic therapy after transcatheter aortic valve replacement (TAVR) remains unclear. We evaluated the association between antithrombotic regimens and outcomes in TAVR patients. We retrospectively analyzed consecutive patients who underwent TAVR at a single academic center from April 2009 to March 2014. Antithrombotic regimens were classified as single or dual antiplatelet therapy (AP), single antiplatelet plus anticoagulant (SAC), or triple therapy (TT). The primary endpoint was a composite of death, myocardial infarction (MI), stroke, and major bleeding. Adjusted hazard ratios (HRs) were obtained with best subset variable selection methods using bootstrap resampling. Of 246 patients who underwent TAVR, 241 were eligible for analysis with 133, 88, and 20 patients in the AP, SAC, and TT groups, respectively. During a median 2.1-year follow-up, 53.5% had at least one endpoint-the most common was death (68%), followed by major bleeding (23%), stroke (6%), and MI (3%). At 2 years, the composite outcome occurred in 70% of TT, 42% of SAC, and 31% of AP patients. Compared to AP, adjusted HRs for the composite outcome were 2.88 [95% Confidence intervals (CI) (1.61-5.16); p = 0.0004] and 1.66 (95% CI [1.13-2.42]; p = 0.009) in the TT and SAC groups, respectively. Mortality rates at 2 years were 61% in the TT, 32% in the SAC, and 26% in the AP groups (p = 0.005). The risk of the composite outcome of death, MI, stroke, or major bleeding at 2-year follow-up was significantly higher in TAVR patients treated with TT or SAC versus AP, even after multivariate adjustment.

Protective Effect of Contemporary Pertussis Vaccines: A Systematic Review and Meta-analysis.

PubMed

Fulton, T Roice; Phadke, Varun K; Orenstein, Walter A; Hinman, Alan R; Johnson, Wayne D; Omer, Saad B

2016-05-01

Acellular pertussis (aP) and whole-cell (wP) pertussis vaccines are presumed to have similar short-term (<3 years after completion of the primary series) efficacy. However, vaccine effect varies between individual pertussis vaccine formulations, and many originally studied formulations are now unavailable. An updated analysis of the short-term protective effect of pertussis vaccines limited to formulations currently on the market in developed countries is needed. We conducted a systematic review and meta-analysis of published studies that evaluated pertussis vaccine efficacy or effectiveness within 3 years after completion (>3 doses) of a primary series of a currently available aP or wP vaccine formulation. The primary outcome was based on the World Health Organization (WHO) clinical case definitions for pertussis. Study quality was assessed using the approach developed by the Child Health Epidemiology Research Group. We determined overall effect sizes using random-effects meta-analyses, stratified by vaccine (aP or wP) and study (efficacy or effectiveness) type. Meta-analysis of 2 aP vaccine efficacy studies (assessing the 3-component GlaxoSmithKline and 5-component Sanofi-Pasteur formulations) yielded an overall aP vaccine efficacy of 84% (95% confidence interval [CI], 81%-87%). Meta-analysis of 3 wP vaccine effectiveness studies (assessing the Behringwerke, Pasteur/Mérieux, and SmithKline Beecham formulations) yielded an overall wP vaccine effectiveness of 94% (95% CI, 88%-97%) (bothI(2)= 0%). Although all contemporary aP and wP formulations protect against pertussis disease, in this meta-analysis the point estimate for short-term protective effect against WHO-defined pertussis in young children was lower for currently available aP vaccines than wP vaccines. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

75 FR 30405 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... Revocable Trust, James E. Ukrop, Trustee; Robert Stephen Ukrop; The Amended and Restated Robert Stephen Ukrop Revocable Trust, Robert Stephen Ukrop, Trustee; Robert Scott Ukrop; The Amendment and Restatement.... Ukrop; The Robert Stephen Ukrop, Revocable Trust, Joseph Ukrop, Jr., Trustee; Jacquelin Ukrop Aronson...

Robert S. Nelson | NREL

Science.gov Websites

S. Nelson Photo of Robert S. Nelson Robert Nelson Researcher II-Biological Science Robert.Nelson recombinant proteins. His current work is focused on the biological conversion of lignocellulose to advanced

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

Airborne Precision Spacing for Dependent Parallel Operations Interface Study

NASA Technical Reports Server (NTRS)

Volk, Paul M.; Takallu, M. A.; Hoffler, Keith D.; Weiser, Jarold; Turner, Dexter

2012-01-01

This paper describes a usability study of proposed cockpit interfaces to support Airborne Precision Spacing (APS) operations for aircraft performing dependent parallel approaches (DPA). NASA has proposed an airborne system called Pair Dependent Speed (PDS) which uses their Airborne Spacing for Terminal Arrival Routes (ASTAR) algorithm to manage spacing intervals. Interface elements were designed to facilitate the input of APS-DPA spacing parameters to ASTAR, and to convey PDS system information to the crew deemed necessary and/or helpful to conduct the operation, including: target speed, guidance mode, target aircraft depiction, and spacing trend indication. In the study, subject pilots observed recorded simulations using the proposed interface elements in which the ownship managed assigned spacing intervals from two other arriving aircraft. Simulations were recorded using the Aircraft Simulation for Traffic Operations Research (ASTOR) platform, a medium-fidelity simulator based on a modern Boeing commercial glass cockpit. Various combinations of the interface elements were presented to subject pilots, and feedback was collected via structured questionnaires. The results of subject pilot evaluations show that the proposed design elements were acceptable, and that preferable combinations exist within this set of elements. The results also point to potential improvements to be considered for implementation in future experiments.

An Architecture for the Electronic Church: Oral Roberts University in Tulsa, Oklahoma.

PubMed

Grubiak, Margaret M

2016-04-01

More than a university, Oral Roberts University in Tulsa, Oklahoma, was also the headquarters for evangelist Oral Roberts's electronic church. The electronic church in America, dominated by Christian evangelicals, used technology to spread the Gospel over radio airways and television signals to a dispersed audience. Yet evangelicals like Roberts also constructed ambitious campuses in real space and time. The architecture of Oral Roberts University visualized a modern and "populuxe" image for the electronic church in the 1960s and 1970s. The university's Prayer Tower purposely alluded to the Seattle Space Needle, aligning religion and the Space Age, and the campus's white, gold, and black color palette on late modern buildings created an image of aspirational luxury, conveying Roberts's health and wealth gospel. Oral Roberts University served as a sound stage for Roberts's radio and television shows, a pilgrimage point for his audience, and a university dedicated to training evangelicals in the electronic church.

Geomagnetic storms can trigger stroke: evidence from 6 large population-based studies in Europe and Australasia.

PubMed

Feigin, Valery L; Parmar, Priya G; Barker-Collo, Suzanne; Bennett, Derrick A; Anderson, Craig S; Thrift, Amanda G; Stegmayr, Birgitta; Rothwell, Peter M; Giroud, Maurice; Bejot, Yannick; Carvil, Phillip; Krishnamurthi, Rita; Kasabov, Nikola

2014-06-01

Although the research linking cardiovascular disorders to geomagnetic activity is accumulating, robust evidence for the impact of geomagnetic activity on stroke occurrence is limited and controversial. We used a time-stratified case-crossover study design to analyze individual participant and daily geomagnetic activity (as measured by Ap Index) data from several large population-based stroke incidence studies (with information on 11 453 patients with stroke collected during 16 031 764 person-years of observation) in New Zealand, Australia, United Kingdom, France, and Sweden conducted between 1981 and 2004. Hazard ratios and corresponding 95% confidence intervals (CIs) were calculated. Overall, geomagnetic storms (Ap Index 60+) were associated with 19% increase in the risk of stroke occurrence (95% CI, 11%-27%). The triggering effect of geomagnetic storms was most evident across the combined group of all strokes in those aged <65 years, increasing stroke risk by >50%: moderate geomagnetic storms (60-99 Ap Index) were associated with a 27% (95% CI, 8%-48%) increased risk of stroke occurrence, strong geomagnetic storms (100-149 Ap Index) with a 52% (95% CI, 19%-92%) increased risk, and severe/extreme geomagnetic storms (Ap Index 150+) with a 52% (95% CI, 19%-94%) increased risk (test for trend, P<2×10(-16)). Geomagnetic storms are associated with increased risk of stroke and should be considered along with other established risk factors. Our findings provide a framework to advance stroke prevention through future investigation of the contribution of geomagnetic factors to the risk of stroke occurrence and pathogenesis. © 2014 American Heart Association, Inc.

Small Scales Structure of MHD Turbulence, Tubes or Ribbons?

NASA Astrophysics Data System (ADS)

Verdini, A.; Grappin, R.; Alexandrova, O.; Lion, S.

2017-12-01

Observations in the solar wind indicate that turbulent eddies change their anisotropy with scales [1]. At large scales eddies are elongated in direction perpendicular to the mean-field axis. This is the result of solar wind expansion that affects both the anisotropy and single-spacecraft measurments [2,3]. At small scales one recovers the anisotropy expected in strong MHD turbulence and constrained by the so-called critical balance: eddies are elongated along the mean-field axis. However, the actual eddy shape is intermediate between tubes and ribbons, preventing us to discriminate between two concurrent theories that predict 2D axysimmetric anisotropy [4] or full 3D anisotropy [5]. We analyse 10 years of WIND data and apply a numerically-derived criterion to select intervals in which solar wind expansion is expected to be negligible. By computing the anisotropy of structure functions with respect to the local mean field we obtain for the first time scaling relations that are in agreement with full 3D anisotropy, i.e. ribbons-like structures. However, we cannot obtain the expected scaling relations for the alignment angle which, according to the theory, is physically responsible for the departure from axisymmetry. In addition, a further change of anisotropy occurs well above the proton scales. We discuss the implication of our findings and how numerical simulations can help interpreting the observed spectral anisotropy. [1] Chen et al., ApJ, 768:120, 2012 [2] Verdini & Grappin, ApJL, 808:L34, 2015 [3] Vech & Chen, ApJL, 832:L16, 2016 [4] Goldreich & Shridar, ApJ, 438:763, 1995 [5] Boldyrev, ApJL, 626:L37, 2005

In Brief: Online database for instantaneous streamflow data

NASA Astrophysics Data System (ADS)

Showstack, Randy

2007-11-01

Access to U.S. Geological Survey (USGS) historical instantaneous streamflow discharge data, dating from around 1990, is now available online through the Instantaneous Data Archive (IDA), the USGS announced on 14 November. In this new system, users can find streamflow information reported at the time intervals at which it is collected, typically 15-minute to hourly intervals. Although instantaneous data have been available for many years, they were not accessible through the Internet. Robert Hirsch, USGS Associate Director of Water, said, ``A user-friendly archive of historical instantaneous streamflow data is important to many different users for such things as floodplain mapping, flood modeling, and estimating pollutant transport.''The site currently has about 1.5 billion instantaneous data values from 5500 stream gages in 26 states. The number of states and stream gages with data will continue to increase, according to the USGS. For more information, visit the Web site: http://ida.water.usgs.gov/ida/.

A fermentative approach towards optimizing directed biosynthesis of fumaric acid by Rhizopus oryzae 1526 utilizing apple industry waste biomass.

PubMed

Das, Ratul Kumar; Brar, Satinder Kaur; Verma, Mausam

2015-12-01

The present research account deals with the bioproduction of fumaric acid (FA) from apple pomace ultrafiltration sludge (APUS) and apple pomace (AP) through fermentation. The filamentous fungus Rhizopus oryzae 1526 was used as a biocatalyst and its morphological impact on FA production was analysed in detail. For submerged fermentation, 40 g L(-1) of total solids concentration of APUS, pH 6.0, 30 °C, 200 rpm flask shaking speed and 72 h of incubation were found to be optimum for FA production (25.2 ± 1.0 g L(-1), 0.350 g (L(-1) h(-1))). Broth viscosity (cP), residual reducing sugar (g L(-1)) and ethanol (g L(-1)) produced as by-product, were also analysed. Plastic trays were used for solid state fermentation and at optimized level of moisture and incubation period, 52 ± 2.67 g FA per kg dry weight of AP was obtained. Changes in the total phenolic content (mg g(-1) dry weight of AP) were monitored at regular intervals. Utilization of APUS and AP for the directed synthesis of the high-value platform chemical FA by the fungal strain R. oryzae 1526 was an excellent display of fungal physiological and morphological control over a fermentative product. Copyright © 2015 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

The treatment with pyridostigmine improves the cardiocirculatory function in rats with chronic heart failure.

PubMed

Sabino, João Paulo J; da Silva, Carlos Alberto Aguiar; de Melo, Rubens Fernando; Fazan, Rubens; Salgado, Helio C

2013-01-01

Sympathetic hyperactivity and its outcome in heart failure have been thoroughly investigated to determine the focus of pharmacologic approaches targeting the sympathetic nervous system in the treatment of this pathophysiological condition. On the other hand, therapeutic approaches aiming to protect the reduced cardiac parasympathetic function have not received much attention. The present study evaluated rats with chronic heart failure (six to seven weeks after coronary artery ligation) and the effects of an increased parasympathetic function by pyridostigmine (an acetylcholinesterase inhibitor) on the following aspects: arterial pressure (AP), heart rate (HR), baroreceptor and Bezold-Jarisch reflex, pulse interval (PI) and AP variability, cardiac sympathetic and parasympathetic tonus, intrinsic heart rate (i-HR) and cardiac function. Conscious rats with heart failure exhibited no change in HR, Bezold-Jarisch reflex, PI variability and cardiac sympathetic tonus. On the other hand, these animals presented hypotension and reduced baroreflex sensitivity, power in the low frequency (LF) band of the systolic AP spectrum, cardiac parasympathetic tonus and i-HR, while anesthetized rats exhibited reduced cardiac performance. Pyridostigmine prevented the attenuation of all the parameters examined, except basal AP and cardiac performance. In conclusion, the blockade of acetylcholinesterase with pyridostigmine was revealed to be an important pharmacological approach, which could be used to increase parasympathetic function and to improve a number of cardiocirculatory parameters in rats with heart failure. Copyright © 2012 Elsevier B.V. All rights reserved.

Tank 241-AP-105, cores 208, 209 and 210, analytical results for the final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuzum, J.L.

1997-10-24

This document is the final laboratory report for Tank 241-AP-105. Push mode core segments were removed from Risers 24 and 28 between July 2, 1997, and July 14, 1997. Segments were received and extruded at 222-S Laboratory. Analyses were performed in accordance with Tank 241-AP-105 Push Mode Core Sampling and Analysis Plan (TSAP) (Hu, 1997) and Tank Safety Screening Data Quality Objective (DQO) (Dukelow, et al., 1995). None of the subsamples submitted for total alpha activity (AT), differential scanning calorimetry (DSC) analysis, or total organic carbon (TOC) analysis exceeded the notification limits as stated in TSAP and DQO. The statisticalmore » results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems Technical Basis Group, and are not considered in this report. Appearance and Sample Handling Two cores, each consisting of four segments, were expected from Tank 241-AP-105. Three cores were sampled, and complete cores were not obtained. TSAP states core samples should be transported to the laboratory within three calendar days from the time each segment is removed from the tank. This requirement was not met for all cores. Attachment 1 illustrates subsamples generated in the laboratory for analysis and identifies their sources. This reference also relates tank farm identification numbers to their corresponding 222-S Laboratory sample numbers.« less

The Future of Educational Research.

ERIC Educational Resources Information Center

Farley, Frank H., Ed.

1982-01-01

Seven past presidents of the American Educational Research Association discuss trends and the probable nature of educational research in the 1980s. Authors include N.L. Gage, Benjamin S. Bloom, David R. Krathwohl, Robert M. Gagne, Robert Glaser, Robert Ebel, and Robert L. Thorndike. (GC)

40 CFR 1066.610 - Dilution air background correction.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... a = atomic hydrogen-to-carbon ratio of the test fuel. You may measure a or use default values from Table 1 of 40 CFR 1065.655. b = atomic oxygen-to-carbon ratio of the test fuel. You may measure b or use.... ER28AP14.100 Where: x CO2 = amount of CO2 measured in the sample over the test interval. x NMHC = amount of...

Fine-mapping and initial characterization of QT interval loci in African Americans.

PubMed

Avery, Christy L; Sethupathy, Praveen; Buyske, Steven; He, Qianchuan; Lin, Dan-Yu; Arking, Dan E; Carty, Cara L; Duggan, David; Fesinmeyer, Megan D; Hindorff, Lucia A; Jeff, Janina M; Klein, Liviu; Patton, Kristen K; Peters, Ulrike; Shohet, Ralph V; Sotoodehnia, Nona; Young, Alicia M; Kooperberg, Charles; Haiman, Christopher A; Mohlke, Karen L; Whitsel, Eric A; North, Kari E

2012-01-01

The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have examined European ancestral populations; however, the increased genetic diversity in African Americans provides opportunities to narrow association signals and identify population-specific variants. We therefore evaluated 6,670 SNPs spanning eleven previously identified QT loci in 8,644 African American participants from two Population Architecture using Genomics and Epidemiology (PAGE) studies: the Atherosclerosis Risk in Communities study and Women's Health Initiative Clinical Trial. Of the fifteen known independent QT variants at the eleven previously identified loci, six were significantly associated with QT in African American populations (P≤1.20×10(-4)): ATP1B1, PLN1, KCNQ1, NDRG4, and two NOS1AP independent signals. We also identified three population-specific signals significantly associated with QT in African Americans (P≤1.37×10(-5)): one at NOS1AP and two at ATP1B1. Linkage disequilibrium (LD) patterns in African Americans assisted in narrowing the region likely to contain the functional variants for several loci. For example, African American LD patterns showed that 0 SNPs were in LD with NOS1AP signal rs12143842, compared with European LD patterns that indicated 87 SNPs, which spanned 114.2 Kb, were in LD with rs12143842. Finally, bioinformatic-based characterization of the nine African American signals pointed to functional candidates located exclusively within non-coding regions, including predicted binding sites for transcription factors such as TBX5, which has been implicated in cardiac structure and conductance. In this detailed evaluation of QT loci, we identified several African Americans SNPs that better define the association with QT and successfully narrowed intervals surrounding established loci. These results demonstrate that the same loci influence variation in QT across multiple populations, that novel signals exist in African Americans, and that the SNPs identified as strong candidates for functional evaluation implicate gene regulatory dysfunction in QT prolongation.

Fine-Mapping and Initial Characterization of QT Interval Loci in African Americans

PubMed Central

Avery, Christy L.; Sethupathy, Praveen; Buyske, Steven; He, Qianchuan; Lin, Dan-Yu; Arking, Dan E.; Carty, Cara L.; Duggan, David; Fesinmeyer, Megan D.; Hindorff, Lucia A.; Jeff, Janina M.; Klein, Liviu; Patton, Kristen K.; Peters, Ulrike; Shohet, Ralph V.; Sotoodehnia, Nona; Young, Alicia M.; Kooperberg, Charles; Haiman, Christopher A.; Mohlke, Karen L.; Whitsel, Eric A.; North, Kari E.

2012-01-01

The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have examined European ancestral populations; however, the increased genetic diversity in African Americans provides opportunities to narrow association signals and identify population-specific variants. We therefore evaluated 6,670 SNPs spanning eleven previously identified QT loci in 8,644 African American participants from two Population Architecture using Genomics and Epidemiology (PAGE) studies: the Atherosclerosis Risk in Communities study and Women's Health Initiative Clinical Trial. Of the fifteen known independent QT variants at the eleven previously identified loci, six were significantly associated with QT in African American populations (P≤1.20×10−4): ATP1B1, PLN1, KCNQ1, NDRG4, and two NOS1AP independent signals. We also identified three population-specific signals significantly associated with QT in African Americans (P≤1.37×10−5): one at NOS1AP and two at ATP1B1. Linkage disequilibrium (LD) patterns in African Americans assisted in narrowing the region likely to contain the functional variants for several loci. For example, African American LD patterns showed that 0 SNPs were in LD with NOS1AP signal rs12143842, compared with European LD patterns that indicated 87 SNPs, which spanned 114.2 Kb, were in LD with rs12143842. Finally, bioinformatic-based characterization of the nine African American signals pointed to functional candidates located exclusively within non-coding regions, including predicted binding sites for transcription factors such as TBX5, which has been implicated in cardiac structure and conductance. In this detailed evaluation of QT loci, we identified several African Americans SNPs that better define the association with QT and successfully narrowed intervals surrounding established loci. These results demonstrate that the same loci influence variation in QT across multiple populations, that novel signals exist in African Americans, and that the SNPs identified as strong candidates for functional evaluation implicate gene regulatory dysfunction in QT prolongation. PMID:22912591

A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation.

PubMed

Bartos, Daniel C; Giudicessi, John R; Tester, David J; Ackerman, Michael J; Ohno, Seiko; Horie, Minoru; Gollob, Michael H; Burgess, Don E; Delisle, Brian P

2014-03-01

Type 1 long QT syndrome (LQT1) is caused by loss-of-function mutations in the KCNQ1-encoded Kv7.1 channel that conducts the slowly activating component of the delayed rectifier K(+) current (IKs). Clinically, the diagnosis of LQT1 is complicated by variable phenotypic expressivity, whereby approximately 25% of genotype-positive individuals present with concealed LQT1 (resting corrected QT [QTc] interval ≤460 ms). To determine whether a specific molecular mechanism contributes to concealed LQT1. We identified a multigenerational LQT1 family whereby 79% of the patients genotype-positive for p.Ile235Asn-KCNQ1 (I235N-Kv7.1) have concealed LQT1. We assessed the effect I235N-Kv7.1 has on IKs and the ventricular action potential (AP) by using in vitro analysis and computational simulations. Clinical data showed that all 10 patients with I235N-Kv7.1 have normal resting QTc intervals but abnormal QTc interval prolongation during the recovery phase of an electrocardiographic treadmill stress test. Voltage-clamping HEK293 cells coexpressing wild-type Kv7.1 and I235N-Kv7.1 (to mimic the patients' genotypes) showed that I235N-Kv7.1 generated relatively normal functioning Kv7.1 channels but were insensitive to protein kinase A (PKA) activation. Phosphomimetic and quinidine sensitivity studies suggest that I235N-Kv7.1 limits the conformational changes in Kv7.1 channels, which are necessary to upregulate IKs after PKA phosphorylation. Computational ventricular AP simulations predicted that the PKA insensitivity of I235N-Kv7.1 is primarily responsible for prolonging the AP with β-adrenergic stimulation, especially at slower cycle lengths. KCNQ1 mutations that generate relatively normal Kv7.1 channels, but limit the upregulation of IKs by PKA activation, likely contribute to concealed LQT1. Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Frequency and prognosis of acute pancreatitis associated with fulminant or non-fulminant acute hepatitis A: A systematic review.

PubMed

Haffar, Samir; Bazerbachi, Fateh; Prokop, Larry; Watt, Kymberly D; Murad, M Hassan; Chari, Suresh T

Acute pancreatitis (AP) in patients with fulminant viral hepatitis is well recognized and its mortality depends on the severity of hepatitis rather than pancreatitis. Acute pancreatitis associated with non-fulminant acute hepatitis A (AHA) has been rarely described, and is considered to have a benign course with good response to conservative management. To perform a systematic review of the frequency and prognosis of AP associated with fulminant or non-fulminant AHA. An increasing number of reports describe AP associated with AHA. Some life-threatening complications related to AP may occur, and death has been reported. In addition, it is possible that early diagnosis of these cases may help in reducing the morbidity and mortality. Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Scopus, Google Scholar, and reference lists of relevant articles. All available studies discussing AP associated with fulminant or non-fulminant AHA. Two blinded independent observers extracted and assessed the frequency of AP associated with AHA based on large studies including all cases of AHA observed during a prolonged period of time, diagnosis of AHA based on anti-HAV IgM, diagnosis of fulminant hepatitis (FH) based on the American Association for the study of Liver Diseases (AASLD) position paper, diagnosis of AP based on the American College of Gastroenterology (ACG) guidelines, diagnosis of AP associated with AHA based on Makharia's association, and diagnosis of AP severity based on the Revision of the Atlanta Classification (RAC). We have developed a tool for risk of bias assessment of case reports and case-series and applied it to the included studies. The frequency of reported AP associated with AHA is 0-0.1%. Thirty-eight publications with a total of 54 patients meeting the inclusion criteria have been published. Twenty-two studies had a low risk for bias, 10 had moderate risk and 6 had high risk. Patients originated from all continents but most of them were from Asia. The median age at diagnosis was 16 years (range: 2-81) with a male to female ratio of 2. The median interval between the onset of jaundice and onset of AP pain was 4 days (range: 0-30). AP was severe in 9% of patients. The median hospital stay for AP was 8 days (range: 3-35). Most cases occur in patients without FH (94%). Mortality was reported in 2 patients (3.7%). Acute pancreatitis associated with AHA is rare with an estimated frequency of 0-0.1%. Fifty-four documented cases, mostly in Asian patients, have been reported. The median age of patients is 16 years with a M/F ratio of 2. Acute pancreatitis occurs less than one week after the onset of jaundice and mostly in patients without FH. Acute pancreatitis in this setting is severe in 9% of patients with a mortality rate similar to all other causes of AP. Copyright © 2017 IAP and EPC. Published by Elsevier B.V. All rights reserved.

a Look at Nitrile Chemistry in SGR B2(N) Using the Combined Power of the GBT and the VLA

NASA Astrophysics Data System (ADS)

Steber, Amanda; Zaleski, Daniel P.; Seifert, Nathan A.; Neill, Justin; Muckle, Matt; Pate, Brooks; Corby, Joanna F.; Remijan, Anthony

2014-06-01

Nitriles form the most prolific family of molecules known in the ISM, and laboratory work shows that radical-driven chemistry can account for the formation of a diverse set of nitrile and imine molecules. Broadband reaction screening of nitrile chemistry in a pulsed discharge nozzle coupled to a chirped-pulse Fourier transform rotational spectrometer has enabled detections of several new interstellar species including E- and Z-ethanimine and E-cyanomethanimine. The detections were made by direct comparisons of laboratory broadband rotational spectra with the Robert C. Byrd Green Bank Telescope (GBT) PRebiotic Interstellar MOlecule Survery (PRIMOS) survey towards Sgr B2(N), the most chemically complex interstellar region known. In order to probe nitrile chemistry in Sgr B2, we targeted low energy rotational transitions in the 18-21 GHz range of several nitriles with the Karl G. Jansky Very Large Array (VLA) at ˜1 arcsecond resolution. The data indicate that most nitriles and nitrile derivatives are co-spatial with shell shaped continuum features thought to be expanding ionization fronts. The CH2CN radical and imine species in particular are NOT associated with the hot core known as the "Large Molecule Heimat", where most large organic molecules are thought to reside. This result suggests radical driven nitrile chemistry may be promoted by near-UV radiation in moderate density regions of molecular clouds, and the data will be useful for evaluating possible formation mechanisms. R.A. Loomis et al. Ap. J. L., 765, (L9), 2013. D.P. Zaleski et al. Ap. J. L., 765, (L10), 2013.

The nature of dust around the post-asymptotic giant branch objects HD 161796 and HD 179821

NASA Technical Reports Server (NTRS)

Justtanont, K.; Barlow, M. J.; Skinner, C. J.; Tielens, A. G. G. M.

1992-01-01

Ground-based 7.4-24-micron spectra of two post-AGB objects, HD 161796 and HD 179821, are reported, and they are compared to those of other preplanetary nebulae. HD 161796 and HD 17982 show emission features at 10-12 microns and at 10 microns, and they exhibit a very rapid increase in flux between 13 and 15.5 microns. In view of the O-rich photosphere of HD 161796 and the presence of OH maser emission around all three objects, these features are ascribed to various oxides. The observed spectral features are quite different from the canonical silicate features observed in most O-rich giants. It is argued that HD 161796 and the bipolar nebulae Roberts 22 and NGC 6302 have all undergone the third dredge-up, with most of the dredged-up carbon having been converted to nitrogen by envelope-burning. It is concluded that carbon-rich grain material, produced during the interval between the end of the third dredge-up and the moment when envelope burning finally reduced the C/O ratio below unity again, could be responsible for the UIR bands now being excited in Roberts 22 and NGC 6302.

77 FR 40609 - Robert D. Willis Power Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

... DEPARTMENT OF ENERGY Southwestern Power Administration Robert D. Willis Power Rate AGENCY... proposed Robert D. Willis rate schedule, which is supported by a power repayment study, to recover the... existing Robert D. Willis rate for the period October 1, 2008 through September 30, 2012. See 127 FERC...

One followed by many?-Long-term effects of a celebrity suicide on the number of suicidal acts on the German railway net.

PubMed

Hegerl, Ulrich; Koburger, Nicole; Rummel-Kluge, Christine; Gravert, Christian; Walden, Martin; Mergl, Roland

2013-03-20

Following the railway suicide of Robert Enke, a famous German football goal keeper, short-term copycat effects have been found. Main aims of the present study were to analyze long-term effects of this incidence and to compare them with overall national suicide data, as well as to investigate possible "anniversary effects". For long-term effects, the number of railway suicidal acts in the two years before and after Robert Enke's suicide (10th November 2009) were compared. For anniversary effects, the corresponding 2-week-periods in 2009, 2010 and 2011 were analyzed. Incidence ratios with 95% confidence intervals were computed. Compared to the two years before Enke's suicide the incidence ratio of the number of railway suicidal acts in the 2-year-period following this event increased by 18.8% (95% confidence interval (CI)=11.0-27.1%; p<0.001). The median number of suicidal acts per day increased from 2 to 3 (p<0.001). This effect remains significant after excluding short-term 2-week effects of Enke's suicide. An anniversary effect was not present. The increase of fatal railway suicides between 2007 and 2010 (25%) was significantly different from that for the total number of suicides in Germany (6.6%) (p<0.0001). Due to missing data, analyses regarding gender were limited and regarding age not feasible. Long-term effects of Enke's suicide on railway suicidal acts in Germany in the sense of copycat behavior are probable as this increase cannot be explained by corresponding changes of the total number of suicides in Germany. Copyright © 2012 Elsevier B.V. All rights reserved.

Flora: A Proposed Hyperspectral Mission

NASA Technical Reports Server (NTRS)

Ungar, Stephen; Asner, Gregory; Green, Robert; Knox, Robert

2006-01-01

In early 2004, one of the authors (Stephen Ungar, NASA GSFC) presented a mission concept called "Spectrasat" at the AVIRIS Workshop in Pasadena, CA. This mission concept grew out of the lessons learned from the Earth Observing-One (EO-1) Hyperion Imaging Spectrometer and was structured to more effectively accomplish the types of studies conducted with Hyperion. The Spectrasat concept represented an evolution of the technologies and operation strategies employed on EO-I. The Spectrasat concept had been preceded by two community-based missions proposed by Susan Ustin, UC Davis and Robert Green, NASA JPL. As a result of community participation, starting at this AVIRIS Workshop, the Spectrasat proposal evolved into the Flora concept which now represents the combined visions of Gregory Asner (Carnegie Institute), Stephen Ungar, Robert Green and Robert Knox, NASA GSFC. Flora is a proposed imaging spectrometer mission, designed to address global carbon cycle science issues. This mission centers on measuring ecological disturbance for purposes of ascertaining changes in global carbon stocks and draws heavily on experience gained through AVIRIS airborne flights and Hyperion space born flights. The observing strategy exploits the improved ability of imaging spectrometers, as compared with multi-spectral observing systems, to identify vegetation functional groups, detect ecosystem response to disturbance and assess the related discovery. Flora will be placed in a sun synchronous orbit, with a 45 meter pixel size, a 90 km swath width and a 31 day repeat cycle. It covers the spectral range from 0.4 to 2.5 micrometers with a spectral sampling interval of 10 nm. These specifications meet the needs of the Flora science team under the leadership of Gregory Asner. Robert Green, has introduced a spectrometer design for Flora which is expected to have a SNR of 600: 1 in the VNIR and 450: 1 in the SWIR. The mission team at NASA GSFC is designing an Intelligent Payload Module (IPM) designed to effectively reduce the volume of data required to be transmitted down to the ground. This paper discusses mission science objectives, describes the mission concept and presents the current status of possible funding opportunities leading to realization of the mission.

Getting to Negotiations in Syria: The Shadow of the Future and the Syrian Civil War

DTIC Science & Technology

2014-01-01

parties are that there will be a tomorrow, the more willing they will become to talk about it. As Robert Axelrod and Robert O. Keohane write, “The more...N.J.: Princeton University Press, 2002. 35 Walter, 1997, p. 335. 36 Walter, 1997, p. 336. 37 Robert Axelrod and Robert O. Keohane , “Achieving...sovereign states may choose to cooperate under conditions of anarchy. According to Robert Axel- The literature has focused on conditions prior to or

Use of machine-learning classifiers to predict requests for preoperative acute pain service consultation.

PubMed

Tighe, Patrick J; Lucas, Stephen D; Edwards, David A; Boezaart, André P; Aytug, Haldun; Bihorac, Azra

2012-10-01

  The purpose of this project was to determine whether machine-learning classifiers could predict which patients would require a preoperative acute pain service (APS) consultation.   Retrospective cohort.   University teaching hospital.   The records of 9,860 surgical patients posted between January 1 and June 30, 2010 were reviewed.   Request for APS consultation. A cohort of machine-learning classifiers was compared according to its ability or inability to classify surgical cases as requiring a request for a preoperative APS consultation. Classifiers were then optimized utilizing ensemble techniques. Computational efficiency was measured with the central processing unit processing times required for model training. Classifiers were tested using the full feature set, as well as the reduced feature set that was optimized using a merit-based dimensional reduction strategy.   Machine-learning classifiers correctly predicted preoperative requests for APS consultations in 92.3% (95% confidence intervals [CI], 91.8-92.8) of all surgical cases. Bayesian methods yielded the highest area under the receiver operating curve (0.87, 95% CI 0.84-0.89) and lowest training times (0.0018 seconds, 95% CI, 0.0017-0.0019 for the NaiveBayesUpdateable algorithm). An ensemble of high-performing machine-learning classifiers did not yield a higher area under the receiver operating curve than its component classifiers. Dimensional reduction decreased the computational requirements for multiple classifiers, but did not adversely affect classification performance.   Using historical data, machine-learning classifiers can predict which surgical cases should prompt a preoperative request for an APS consultation. Dimensional reduction improved computational efficiency and preserved predictive performance. Wiley Periodicals, Inc.

Incidence of Parkinson's disease and atypical parkinsonism: Russian population-based study.

PubMed

Winter, Yaroslav; Bezdolnyy, Yury; Katunina, Elena; Avakjan, Gagik; Reese, Jens P; Klotsche, Jens; Oertel, Wolfgang H; Dodel, Richard; Gusev, Eugene

2010-02-15

Data on the incidence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in East European countries and Asia are limited. The objective of this prospective population-based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age-standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01-10.15] for PD, 0.11 (95% CI 0.03-0.23) for multiple system atrophy, 0.14 (95% CI 0.08-0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01-0.12) for corticobasal degeneration. The age-standardized male-to-female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male-to-female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD. (c) 2010 Movement Disorder Society.

Antiphospholipid antibodies and antiphospholipid syndrome in patients presenting with immune thrombocytopenic purpura: a prospective cohort study.

PubMed

Diz-Küçükkaya, R; Hacihanefioğlu, A; Yenerel, M; Turgut, M; Keskin, H; Nalçaci, M; Inanç, M

2001-09-15

The pathogenetic role and the clinical importance of the presence of antiphospholipid antibodies (APAs) in patients with immune thrombocytopenic purpura (ITP) are not clear. In this study, the prevalence and clinical significance of APAs were investigated in patients with ITP. Eighty-two newly diagnosed ITP patients were prospectively studied. They were evaluated for the presence of lupus anticoagulant (LA) and immunoglobulin G/M anticardiolipin antibodies (ACAs). Thirty-one patients (37.8%) were APA positive at diagnosis. No statistically significant differences were found between the APA-positive and APA-negative groups regarding gender, initial platelet counts, or response to methylprednisolone therapy. After 5 years of follow-up, cumulative thrombosis-free survival of APA-positive (n = 31) and APA-negative (n = 51) ITP patients was 39% and 97.7%, respectively. A significant difference was found between these groups by log-rank test (P =.0004). In addition, LA was an important risk marker for the development of thrombosis in ITP patients. After a median follow-up of 38 months, 14 ITP patients (45%) who had APA positivity developed clinical features (thrombosis or fetal losses) of antiphospholipid syndrome (APS). There were no differences between the APA-positive patients with and without APS regarding the initial platelet counts, response to the therapy, or ACA positivity. The positivity rate for LA was significantly higher in those patients with ITP who developed APS (chi(2): P =.0036; relative risk 7.15; 95% confidence interval, 1.7-47). In conclusion, this study indicates that a significant proportion of patients initially presenting with ITP and APA positivity developed APS. In patients with ITP, the persistent presence of APAs is an important risk factor for the development of APS.

Autonomic modulation of arterial pressure and heart rate variability in hypertensive diabetic rats.

PubMed

Farah, Vera de Moura Azevedo; De Angelis, Kátia; Joaquim, Luis Fernando; Candido, Georgia O; Bernardes, Nathalia; Fazan, Rubens; Schaan, Beatriz D'Agord; Irigoyen, Maria-Claudia

2007-08-01

The aim of the present study was to evaluate the autonomic modulation of the cardiovascular system in streptozotocin (STZ)-induced diabetic spontaneously hypertensive rats (SHR), evaluating baroreflex sensitivity and arterial pressure and heart rate variability. Male SHR were divided in control (SHR) and diabetic (SHR+DM, 5 days after STZ) groups. Arterial pressure (AP) and baroreflex sensitivity (evaluated by tachycardic and bradycardic responses to changes in AP) were monitored. Autoregressive spectral estimation was performed for systolic AP (SAP) and pulse interval (PI) with oscillatory components quantified as low (LF:0.2-0.6Hz) and high (HF:0.6-3.0Hz) frequency ranges. Mean AP and heart rate in SHR+DM (131+/-3 mmHg and 276+/-6 bpm) were lower than in SHR (160+/-7 mmHg and 330+/-8 bpm). Baroreflex bradycardia was lower in SHR+DM as compared to SHR (0.55+/-0.1 vs. 0.97+/-0.1 bpm/mmHg). Overall SAP variability in the time domain (standard deviation of beat-by-beat time series of SAP) was lower in SHR+DM (3.1+/-0.2 mmHg) than in SHR (5.7+/-0.6 mmHg). The standard deviation of the PI was similar between groups. Diabetes reduced the LF of SAP (3.3+/-0.8 vs. 28.7+/-7.6 mmHg2 in SHR), while HF of SAP were unchanged. The power of oscillatory components of PI did not differ between groups. These results show that the association of hypertension and diabetes causes an impairment of the peripheral cardiovascular sympathetic modulation that could be, at least in part, responsible for the reduction in AP levels. Moreover, this study demonstrates that diabetes might actually impair the reduced buffer function of the baroreceptors while reducing blood pressure.

Effect of Ablation of Area Postrema on Frequency and Latency of Motion Sickness-Induced Emesis in the Squirrel Monkey

NASA Technical Reports Server (NTRS)

Brizzee, K. R.; Ordy, J. M.; Mehler, W. R.

1980-01-01

Twelve young adult squirrel monkeys of the Bolivian subspecies were subjected to continuous counter-clockwise horizontal rotary motion at 25 rpm, together with a sinusoidal vertical excursion of 6 in. every 2 sec (0.5 Hz). Each animal was exposed to this motion regimen for a period of 60 min once each week for three consecutive weeks. Following the third weekly motion test bilateral ablation of the Area Postrema (AP) was performed in eight of the animals by thermal cautery. Two control animals were sham-operated after the third motion test while two additional controls were given the motion tests as noted above but were not operated. The four controls were considered as a single group for statistical analyses of results of the motion tests. After a recovery period of 30 to 40 days, and at a comparable interval in the non-operated controls, each animal was again tested for motion sensitivity for three consecutive weeks. The brains of all of the animals were then fixed by left ventriculal cardiac perfusion with Bouin's fluid and processed for histological evaluation of the bilateral AP ablation in comparison with the control brains. Five of the AP-ablated animals postoperatively were completely refractory to the motion stimuli, two exhibited a decreased number of emetic responses, and one exhibited the same number of responses before and after the AP lesions. The controls exhibited no significant difference in emetic sensitivity on the second series of three weekly tests than on the first series. The results of this investigation appear to be in agreement with the observations of Wang and Chinn in the dog indicating that the integrity of the AP (CTZ) is essential to the emetic response to motion.

Muscle Mass Loss Is a Potential Predictor of 90-Day Mortality in Older Adults with Aspiration Pneumonia.

PubMed

Maeda, Keisuke; Akagi, Junji

2017-01-01

To investigate the association between loss of muscle mass and aspiration pneumonia (AP). Prospective observational cohort. Acute geriatric hospital. Individuals admitted to the hospital for AP (N = 151; mean age 85.9; 49.7% male). Appendicular skeletal muscle index (ASMI; appendicular skeletal muscle mass divided by height squared) was used to evaluate muscle mass. Data on age, sex, body mass index, Mini Nutritional Assessment-Short Form score, Barthel Index score, Charlson Comorbidity Index score, and pneumonia severity (Japanese version of the CURB-65 (C (confusion), U (blood urea nitrogen ≥20 mg/dL), R (respiratory rate ≥30 breaths/min), B (systolic blood pressure <90 mmHg or diastolic blood pressure ≤60 mmHg), 65 (aged ≥65) severity score (A-DROP)) were obtained. Outcomes included 30- and 90-day mortality. Mild, moderate, severe, and extremely severe AP were observed in 1.3%, 70.2%, 25.8%, and 2.6% of participants, respectively. On Kaplan-Meier analysis, participants in the lowest ASMI quartile for each sex were more likely to die than those in the other quartiles (log-lank test P = .005). Multivariate logistic analyses showed that ASMI and A-DROP were independent predictors of 90-day mortality; only A-DROP was a significant predictor of 30-day mortality (P < .001). Cox regression analysis also showed that the first ASMI quartile was independently associated with mortality (hazard ratio = 2.19; 95% confidence interval = 1.06-4.52; P = .03). Low muscle mass is a potential predictor of long-term mortality in individuals with AP. Prospectively preventing muscle mass deterioration may be beneficial for recovery from AP in older adults. © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-09

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

Robert Preus | NREL

Science.gov Websites

| 303-384-7284 Robert's expertise is in design and manufacture of small and midsized wind generators certification support for small wind manufacturers. Robert has 28 years of experience in wind energy. He led the section for wind in the National Electrical Code. In 2010, Robert received the Small Wind Advocate award

Pro‐arrhythmic atrial phenotypes in incrementally paced murine Pgc1β −/− hearts: effects of age

PubMed Central

Valli, Haseeb; Ahmad, Shiraz; Fraser, James A.; Jeevaratnam, Kamalan

2017-01-01

New Findings What is the central question of this study? Can we experimentally replicate atrial pro‐arrhythmic phenotypes associated with important chronic clinical conditions, including physical inactivity, obesity, diabetes mellitus and metabolic syndrome, compromising mitochondrial function, and clarify their electrophysiological basis? What is the main finding and its importance? Electrocardiographic and intracellular cardiomyocyte recording at progressively incremented pacing rates demonstrated age‐dependent atrial arrhythmic phenotypes in Langendorff‐perfused murine Pgc1β −/− hearts for the first time. We attributed these to compromised action potential conduction and excitation wavefronts, whilst excluding alterations in recovery properties or temporal electrophysiological instabilities, clarifying these pro‐arrhythmic changes in chronic metabolic disease. Atrial arrhythmias, most commonly manifesting as atrial fibrillation, represent a major clinical problem. The incidence of atrial fibrillation increases with both age and conditions associated with energetic dysfunction. Atrial arrhythmic phenotypes were compared in young (12–16 week) and aged (>52 week) wild‐type (WT) and peroxisome proliferative activated receptor, gamma, coactivator 1 beta (Ppargc1b)‐deficient (Pgc1β −/−) Langendorff‐perfused hearts, previously used to model mitochondrial energetic disorder. Electrophysiological explorations were performed using simultaneous whole‐heart ECG and intracellular atrial action potential (AP) recordings. Two stimulation protocols were used: an S1S2 protocol, which imposed extrasystolic stimuli at successively decremented intervals following regular pulse trains; and a regular pacing protocol at successively incremented frequencies. Aged Pgc1β −/− hearts showed greater atrial arrhythmogenicity, presenting as atrial tachycardia and ectopic activity. Maximal rates of AP depolarization (dV/dt max) were reduced in Pgc1β −/− hearts. Action potential latencies were increased by the Pgc1β −/− genotype, with an added interactive effect of age. In contrast, AP durations to 90% recovery (APD90) were shorter in Pgc1β −/− hearts despite similar atrial effective recovery periods amongst the different groups. These findings accompanied paradoxical decreases in the incidence and duration of alternans in the aged and Pgc1β −/− hearts. Limiting slopes of restitution curves of APD90 against diastolic interval were correspondingly reduced interactively by Pgc1β −/− genotype and age. In contrast, reduced AP wavelengths were associated with Pgc1β −/− genotype, both independently and interacting with age, through the basic cycle lengths explored, with the aged Pgc1β −/− hearts showing the shortest wavelengths. These findings thus implicate AP wavelength in possible mechanisms for the atrial arrhythmic changes reported here. PMID:28960529

The "Chaos Theory" and nonlinear dynamics in heart rate variability analysis: does it work in short-time series in patients with coronary heart disease?

PubMed

Krstacic, Goran; Krstacic, Antonija; Smalcelj, Anton; Milicic, Davor; Jembrek-Gostovic, Mirjana

2007-04-01

Dynamic analysis techniques may quantify abnormalities in heart rate variability (HRV) based on nonlinear and fractal analysis (chaos theory). The article emphasizes clinical and prognostic significance of dynamic changes in short-time series applied on patients with coronary heart disease (CHD) during the exercise electrocardiograph (ECG) test. The subjects were included in the series after complete cardiovascular diagnostic data. Series of R-R and ST-T intervals were obtained from exercise ECG data after sampling digitally. The range rescaled analysis method determined the fractal dimension of the intervals. To quantify fractal long-range correlation's properties of heart rate variability, the detrended fluctuation analysis technique was used. Approximate entropy (ApEn) was applied to quantify the regularity and complexity of time series, as well as unpredictability of fluctuations in time series. It was found that the short-term fractal scaling exponent (alpha(1)) is significantly lower in patients with CHD (0.93 +/- 0.07 vs 1.09 +/- 0.04; P < 0.001). The patients with CHD had higher fractal dimension in each exercise test program separately, as well as in exercise program at all. ApEn was significant lower in CHD group in both RR and ST-T ECG intervals (P < 0.001). The nonlinear dynamic methods could have clinical and prognostic applicability also in short-time ECG series. Dynamic analysis based on chaos theory during the exercise ECG test point out the multifractal time series in CHD patients who loss normal fractal characteristics and regularity in HRV. Nonlinear analysis technique may complement traditional ECG analysis.

Radiographic Assessment of the Robert and Lateral Views in Trapeziometacarpal Osteoarthrosis.

PubMed

Oheb, Jonathan; Lansinger, Yuri; Jansen, Joshua A; Nguyen, Jimmy Q; Porembski, Margaret A; Rayan, Ghazi M

2015-01-01

To evaluate the effectiveness of the Robert view in assessing trapeziometacarpal arthrosis and to compare the accuracy of the Robert and lateral views in staging trapeziometacarpal (TM) joint arthrosis. Patient demographics were obtained. Four participating raters reviewed 62 randomly selected thumb x-rays of patients presenting with thumb TM joint pain. Lateral and Robert-hyperpronation views were assessed using an analysis of 13 criteria. X-rays of 62 thumbs for 58 patients were evaluated. The average patients' age was 64 (47-87) and 51 (80%) were females. The majority of X-rays evaluated fell into stage 3. Stage 2 was the second most common level of arthritis encountered and the least was stage 1. More osteophytes were encountered in the trapezium than metacarpal on both the Robert and lateral views. The Robert view was superior in detecting osteophytes on the trapezium than the lateral view. Osteophyte size varied from 1.7 to 2 mm. The lateral view displayed 61 cases with dorsal metacarpal subluxation (98%). The Robert view displayed 48 cases (77%) with radial metacarpal subluxation and 9 cases (15%) with ulnar metacarpal subluxation. Thumb metacarpal adduction deformity was encountered on the lateral view in 20 cases (32%) whereas on the Robert view it was encountered in 14 cases (23%). Subchondral sclerosis was encountered on the Robert view in 56 thumbs (90%) while it was seen on the lateral view in 52 thumbs (84%). Pantrapezial arthritis involving the STT joint was encountered equally in 16 cases (26%) on the Robert view and the lateral views. The study found a moderate level of interrater reliability on both the lateral and Robert views. With the exception of osteophytes encountered on the trapezium versus the metacarpal, there were no other statistically significant findings. This study confirms that each of the Robert and lateral views offer unique information and combining both views enhances the ability to assess radiographic disease severity, and should be the recommended set of X-rays for assessing TM osteoarthrosis.

76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-17

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-60] Robert G. Crummie, M.D... Registration, BC2964965, issued to Robert G. Crummie, M.D., be, and it hereby is, revoked. I further order that any pending application of Robert G. Crummie, M.D., to renew or modify his registration, be, and it...

[Invasive arterial blood pressure measurement using an aneroid pressure system in cattle].

PubMed

Mosing, M; Franz, S; Iff, I; Schwendenwein, I

2009-06-01

The aim of this study was to compare the results of invasive arterial blood pressure measurement using an electronic pressure transducer (EPT) or an aneroid pressure system (APS) in cattle. A catheter was placed in the auricular artery of 11 adult cattle and connected to a pressure transducer via pressure line. The aneroid system was connected to the same catheter using a three-way stop-cock in the pressure line. On five occasions three consecutive measurements were performed with the APS. The mean blood pressure values of the EPT were recorded before each individual measurement. Values from each device were compared using Passing and Bablok regression of agreement and a Bland and Altman difference plot. One hundred and forty-seven paired measurements were analysed. The average bias between the two methods (EPT vs. APS) was -1.6 mmHg (95 % confidence interval [CI]: -3.0 to -0.2 mmHg). The coefficient of correlation was 1.0084. The aneroid system showed an almost perfect agreement with the EPT. This study shows that it can be used in a clinical setting as well as under field conditions to measure arterial blood pressure in cattle.

Electroconvulsive Therapy for Agitation in Schizophrenia: Metaanalysis of Randomized Controlled Trials.

PubMed

Gu, Xiaojing; Zheng, Wei; Guo, Tong; Ungvari, Gabor S; Chiu, Helen F K; Cao, Xiaolan; D'Arcy, Carl; Meng, Xiangfei; Ning, Yuping; Xiang, Yutao

2017-02-25

Agitation poses a significant challenge in the treatment of schizophrenia. Electroconvulsive therapy (ECT) is a fast, effective and safe treatment for a variety of psychiatric disorders, but no meta-analysis of ECT treatment for agitation in schizophrenia has yet been reported. To systematically evaluate the efficacy and safety of ECT alone or ECT-antipsychotics (APs) combination for agitation in schizophrenia. Systematic literature search of randomized controlled trials (RCTs) was performed. Two independent evaluators selected studies, extracted data about outcomes and safety with available data, conducted quality assessment and data synthesis. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) was used to judge the level of the overall evidence of main outcomes. Seven RCTs from China, including ECT alone (4 RCTs with 5 treatment arms, n=240) and ECT-APs combination (3 RCTs, n=240), were identified. Participants in the studies were on average 34.3(4.5) years of age and lasted an average of 4.3(3.1) weeks of treatment duration. All 7 RCTs were non-blinded, and were rated as low quality based on Jadad scale. Meta-analysis of the pooled sample found no significant difference in the improvement of the agitation sub-score of the Positive and Negative Syndrome Scale (PANSS) when ECT alone (weighted mean difference=-0.90, (95% confidence interval (CI): -2.91, 1.11), p=0.38) or ECT-APs combination (WMD=-1.34, (95%CI: -4.07, 1.39), p=0.33) compared with APs monotherapy. However, ECT alone was superior to APs monotherapy regarding PANSS total score (WMD=-7.13, I 2 =0%, p =0.004) and its excitement sub-score (WMD=-1.97, p <0.0001) as well as the PANSS total score at 14 days (WMD=-7.13, I 2 =0%, p =0.004) and its excitement sub-score at 7 and 14 days (WMD=-1.97 to -1.92, p =0.002 to 0.0001) after ECT. The ECT-APs combination was superior to APs monotherapy with respect to the PANSS total score at treatment endpoint (WMD=-10.40, p=0.03) and 7 days (WMD=-5.01, p =0.02). Headache (number-needed-to-harm (NNH)=3, 95%CI=2-4) was more frequent in the ECT alone group compared to AP monotherapy. According to the GRADE approach, the evidence levels of main outcomes were rated as ''very low'' (37.5%) and "low" (50%). Pooling of the data based on 7 RCTs from China found no advantage of ECT alone or ECT-APs combination in the treatment of agitation related outcomes in schizophrenia patients. However, ECT alone or ECT-APs combination were associated with significant reduction in the PANSS total score. High-quality RCTs are needed to confirm the current interpretations.

Editorial

NASA Astrophysics Data System (ADS)

Kennicutt, Robert C., Jr.

1999-07-01

This issue marks the end of an era for The Astrophysical Journal and for astronomical publishing. Helmut Abt is retiring as Editor-in-Chief after serving for 28 years, a period that saw enormous growth in the Journal and its transformation to the forefront of electronic scientific publishing. In February the ApJ office celebrated the receipt of manuscript number 40,000 under Helmut's tenure, a milestone that testifies to his impact on all of our careers. Although the names at the top of the masthead are changing, the rest of the ApJ team remains nearly unchanged, so the editorial transition should be barely noticeable. Much of the editorial work of the Journal will continue to be performed by our capable staff of Scientific Editors. I am also very fortunate to inherit Helmut's outstanding support staff in Tucson, ably headed by Janice Sexton. Our publications staff in Chicago, led by Julie Steffen, and our electronic publications staff, led by Evan Owens, are unmatched in their dedication and energy, and I have already begun working with them on further improvements to the Journal. And Helmut Abt will continue to serve the Journal over the coming months, overseeing the manuscripts that are still under review and editing the special centennial issue that will appear at the end of this year. In the coming months we will introduce several new features, most of them initiated under Helmut Abt's leadership. These will include an upgraded ApJ homepage, web tools for authors and referees, updated documentation and author instructions, and an attractive new version of the on-line journal itself. Over the longer term we are developing plans for streamlining the publication timescale and for expanding our capabilities for publishing and archiving electronic data. However my overriding priority, always, will be to uphold the Journal's reputation for scientific accuracy, impact, and integrity. I close with a personal note of thanks to Helmut Abt for his patient tutoring over the past six months and for serving as an admirable role model with his dedication, fairness, wisdom, and grace. Our profession owes him an enormous debt of gratitude. ROBERT C. KENNICUTT, JR. Editor-in-Chief

Elevated serum creatinine and hyponatraemia as prognostic factors in canine acute pancreatitis.

PubMed

Marchetti, V; Gori, E; Lippi, I; Luchetti, E; Manca, M L; Pierini, A

2017-11-01

To evaluate prognostic factors for canine acute pancreatitis (AP) based on clinical and laboratory data that can be easily assessed in veterinary practice. Retrospective study between January 2010 and December 2013. The diagnosis of AP was based on clinical signs and an abnormal SNAP® cPL™ test result, concurrently with an ultrasound pattern suggestive of pancreatitis. Dogs were divided into survivors and non-survivors. We evaluated 12 clinical and laboratory parameters: respiratory rate, rectal temperature, white blood cells, haematocrit, total serum proteins, albumin, creatinine, cholesterol, total and ionised calcium, sodium and potassium. Clinical and clinicopathological data were statistically compared between survivors and non-survivors. A value of P < 0.05 was considered significant and P < 0.01 as highly significant. The odds ratio (OR) was calculated. The study enrolled 50 client-owned dogs with a diagnosis of AP. Serum creatinine (P = 0.017) and sodium (P = 0.004) correlated significantly with the outcome. Serum sodium < 139.0 mmol/L (139.0 mEq/L) and serum creatinine > 212 μmol/L (2.4 mg/dL) were associated significantly with poor prognosis. Azotaemia (OR 12.5; 95% confidence interval (CI) 1.32-118.48) and hyponatraemia (OR 4.9; 95% CI 1.36-17.64) were associated with increased risk of death. In dogs with AP, hyponatraemia and azotaemia seem to be significantly associated with an increased risk of death. © 2017 Australian Veterinary Association.

Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR).

PubMed

Olivares, J M; Rodriguez-Morales, A; Diels, J; Povey, M; Jacobs, A; Zhao, Z; Lam, A; Villalobos Vega, J C; Cuéllar, J Alonso; de Castro, F J Alberca; Quintero, C Morillo-Velarde; Martíin, J F Román; Domínguez, P Tabares; Ojeda, J L Prados; Cortés, S Sanz; Cala, F I Mata; Marín, C Gutiérrez; Castro, L Moyano; Duaso, M A Haza; Albarracín, J Requena; Vergara, G Narbona; Benítez, A Fernández; Cleries, F Mayoral; Pérez-Brian, J M García-Herrera; Aragón, A Bordallo; Navarro, J C Rodríguez; Biedma, J A Algarra; de Pedro, R Bravo; González, J F Delgado; López, M E Jaén; Moreno, H Díaz; López, J A Soto; Rodríguez, E Ojeda; de Hoyos, C Martínez; Sacristán, M Pardilla; Martín, M D Molina; Ballesteros, E Martín; Rodríguez, P A Sopelana; Menéndez, L Fernández; Rivas, R Santos; del Pino Cuadrado, P; Lauffer, J Correas; Solano, J J Rodríguez; Martínez, J M Fernández; Solano, F García; Rodríguez, P García-Lamberde; Rodríguez, J A Romero; Cano, T Rodríguez; Fortacin, M Ducaju; Lobeiras, J M Blanco; Sampedro, J M Piñeiro; Bravo, A Pérez; Pellicer, A Fernández; López, M D Alonso; Liste, J Fraga; Fernández, M Riobo; Losada, A Casas; Mendez, R Vazquez-Noguerol; Romero, S Agra; Blanco, J J Blanco; Bonaselt, I Tortajada; Mahia, M C García; del Valle, E Ferrer Gómez; Yañez, P Quiroga; Camarasa, M Gelabert; Alonso, J A Barbado; Mendez, G Florez; Feliz, F Doce; Lamela, M A López; Piñero, M Vega; Alvarado, P Fuentes; Gómez, I López; Martín, P Fadon; Gómez, J L Santos; López, A García; Jiménez, A Rodríguez; Nafs, A Escudero; Barquero, N Casas; Ortiz, R Fernández-Villamor; Noguera, J L Velez; Carrasco, P Ruiz; Muñoz, J Martín; Palma, M Masegoza; Hortelano, C Marín; Bonome, L Sánchez; Sevilla, J Sánchez; Juan, J M Mongil San; Ramos, J M García; Muñoz, J L Vallejo; Guisasola, J Elorza; Vazquez, L Santamaria; Guerras, F Campo; Nebot, F J Arrufat; Fernández, F J Baron; Nicolau, A L Palomo; Subirats, R Catala; Kidias, M Messays; Navarro, V Fabregat; García, B Frades; del Rosal, F Mejias; de Vicente Muñoz, T; Ballester, J Año; Lieb, P Malabia; Martel, A Delgado; Bea, E Roca; Joaquim, I Grau; Enjuanes, F Boatas; Piñol, M Bañuelos; Carbonell, E Fontova I; Muñoz, R Martín; Giribets, C Argila; Sans, L Albages; Blanco, A Serrano; Felipe, M Arcega; Muñoz, P González; Villanueva, A Pons; Arroyo, M Bernardo; Borri, R Coronas; Fallada, S Miret; Merola, M Celma; Rodon, E Parellada; Palmes, J R Pigem; Martínez, E Pérez; Catala, J Matarredona; Coca, A Sandoval; Ferrandiz, F Pascual; Paya, E Ferrandiz; Caballero, G Iturri; Bonet, A Franco; Figueras, J Fluvia; Pagador, P Moreno; Garibo, M Medina; Camo, V Pérez; Carrillo, C Sanz; Valero, C Pelegrin; Rebollo, F J Caro; García Campayo, J; Sala Ayma, J M Sala; Roig, M Martínez; de Uña Mateos, M A; Bertolin, R García; García, A Martín; Mazo, F Jiménez; Velasco, J L Galvez; Pérez, L Santa Maria; Casado, C Jiménez; Barba, J J Mancheño; Diaz, M Conde; Rubio, J P Alcon; Mandoli, A Soler; Herrero, A Uson; Martínez, A Rodríguez; Serrano, P Salgado; Rodríguez, E Nieto; Montesinos, J Segui; Macia, J Ferragud; Mateos Marcos, A Mateos; Soto, J V Pérez-Fuster; Dumont, M Verdaguer; Pagan, J Parra; Martínez, V Balanza; Santiuste de Pablos, M; Delgado, C Espinosa; Quiles, M D Martínez; López, F J Manzanera; Navarro, P Pozo; Torres, A Micol; Ingles, F J Martínez; Arias-Camison, J M Salmeron; Manzano, J C López; Peña, R Villanueva; Guitarte, G Petersen; Fontecilla, H Blasco; Romero, J Barjau; Gil, R Sanz; Lozano, J Marín; Adanez, L Donaire; Zarranz Herrera-Oria, I; Jiménez, J Pérez; Vaz, F Carrato; García, O Sanz; Anton, C Contreras; Casula, R Reixach; Hernandez, M C Natividad; Escabias, F Teba; Torresano, J Rodríguez; Pérez-Villamil, A Huidobro; Estevez, L; Figuero, M Aragües; Muñoz de Morales, A; Calvin, J L Rodríguez; Criado, M Delgado; Rodríguez, V Molina; Ambrosolio, E Balbo; Madera, P M Holgado; Alfaro, G Ponce; Vidal, M M Rojas; Valtuille, A García; Ruiz, O; Cabornero, G Lucas; Echevarria Martínez de Bujo, M; Mallen, M J Maicas; Puigros, J Santandreu; Martorell, A Liñana; Forteza, A Clar; Arrebola, E Rodríguez; Rodríguez de la Torre, M; Saiz, C G Anton; Bardolet I Casas, C; Linde, E Rodríguez; De Arce Cordon, R; Molina, E M Padial; Carazo, F J Ruiz; Romero, J J Muro; Cano, D Vico; Dorado, M Soria; Velazquez, S Campos; Sánchez, A J Rodríguez; Leon, S Ocio; Sánchez, K Pachas; Benitez, M Henry; Zugarramurai, A Intxausti; Contreras, M A; De la Varga González, M; Marín, P Barreiro; Robina, F Gómez; García, M Sánchez; Pérez, F J Otero; Bros, P Cubero; Gómez, A Carrillo; de Dios Molina Martín, J; Perera, J L Carrasco; Averbach, M C; Perera, J L Carrasco; Palancares, E Goenaga; Gallego de Dios, M T; Rojo, C Fernández; Iglesias, S Sánchez; Merino, M I Rubio; Mestre, N Prieto; Urdaniz, A Pérez; Sánchez, J M Martínez; Seco, R Gordo; Muñoz, J Franco; Agut, M Mateos; Lozano, M L Blanco; Herguedas, F Martín; Pena, A Torcal; García, J Vicente; Martínez, A Varona; Sanz Granado, O Sanz; Fernández, M A Medina; Canseco, J M Moran; López, P A Megia; Martín, M A Franco; Barrio, J A Espina; Ubago, J Giner; Bennassar, M Roca; Díez, J M Olivares; Fleta, J L Hernandez; Fortes, F Porras; López, C Arango; Medina, O; Alvarez, D Figuera; Roca, J M Peña; Valladolid, G Rubio; Tavera, J A Furquet; García-Castrillon Sales, J A; Llordes, I Batalla; Melgarejo, C Anchuistegui; Cañas de la Paz, F; Callol, V Vallés; García, M Bousoño; García, J Bobes; Leal, F J Vaz; Corrales, E Cáceres; Iglesias, E Sánchez; Gómez, M A Carreiras; Serrano, G García; Chillarón, E G Román; Aguado, F J Samino; Castillo, J J Molina; González, A González; Vázquez, J Gallardo; Peralvarez, M Bolivar; Diaz, M Rios; Mesa, M Ybarzabal; Artiles, F J Acosta; Chao, M Ajoy; Mesa, M Ybarzabal; del Rosario Santana, P; Escudero, M A García; Berenguer, M Molla; Llacer, J M Bonete; Berna, J A Juan; Ortiz, J Barragán; Pardell, L Tost; Hernández-Alvarez de Sotomayor, C; Méndez, M R Cejas; Garate, R Cabrera; Múgica, B Díaz; González, M Caballero; Domingo, J Pujol; Navarro, C Sáez; Vera, G Selva; Cuquerella, M A; Monzo, J Lonjedo; Boada, P Cervera; Pérez, M F Martín; Parrado, E Carrasco; Sánchez, J J Yañez; Fernández, J Calvo

2009-06-01

The electronic Schizophrenia Treatment Adherence Registry (e-STAR) is a prospective, observational study of patients with schizophrenia designed to evaluate long-term treatment outcomes in routine clinical practice. Parameters were assessed at baseline and at 3 month intervals for 2 years in patients initiated on risperidone long-acting injection (RLAI) (n=1345) or a new oral antipsychotic (AP) (n=277; 35.7% and 36.5% on risperidone and olanzapine, respectively) in Spain. Hospitalization prior to therapy was assessed by a retrospective chart review. At 24 months, treatment retention (81.8% for RLAI versus 63.4% for oral APs, p<0.0001) and reduction in Clinical Global Impression Severity scores (-1.14 for RLAI versus -0.94 for APs, p=0.0165) were significantly higher with RLAI. Compared to the pre-switch period, RLAI patients had greater reductions in the number (reduction of 0.37 stays per patient versus 0.2, p<0.05) and days (18.74 versus 13.02, p<0.01) of hospitalizations at 24 months than oral AP patients. This 2 year, prospective, observational study showed that, compared to oral antipsychotics, RLAI was associated with better treatment retention, greater improvement in clinical symptoms and functioning, and greater reduction in hospital stays and days in hospital in patients with schizophrenia. Improved treatment adherence, increased efficacy and reduced hospitalization with RLAI offer the opportunity of substantial therapeutic improvement in schizophrenia.

Comparative radiographic analysis on the anatomical axis in knee osteoarthritis cases: inter and intraobserver evaluation.

PubMed

Matos, Luiz Felipe; Giordano, Marcos; Cardoso, Gustavo Novaes; Farias, Rafael Baptista; E Albuquerque, Rodrigo Pires

2015-01-01

To make a comparative inter and intraobserver analysis on measurements of the anatomical axis between panoramic radiographs of the lower limbs in anteroposterior (AP) view with bipedal weight-bearing, on short film. An accuracy study comparing radiographic measurements on 47 knees of patients attending the knee surgery outpatient clinic due to osteoarthritis. The radiographic evaluation used was as standardized for the total knee arthroplasty program, including panoramic AP views of the lower limbs and short radiographs of the knees in AP and lateral views, all with bipedal weight-bearing. Following this, the anatomical axis of the lower limbs or the femorotibial angle was measured by five independent examiners on the panoramic and short AP radiographs; three of the examiners were considered to be more experienced and two, less experienced. All the measurements were made again by the same examiners after an interval of not less than 15 days. The statistical analysis was performed using the intraclass correlation coefficient, in order to evaluate the inter and intraobserver concordance of the anatomical axis measurements. From the statistical analysis, it was observed that there was strongly significant concordance between the anatomical axis measurements on the panoramic and short radiographs, for all the five examiners and for both measurements. Under the conditions studied, short radiographs were equivalent to panoramic radiographs for evaluating the anatomical axis of the lower limbs in patients with advanced osteoarthritis. The measurements used also showed high rates of inter and intraobserver concordance and reproducibility.

PRELIMINARY TEST RESULTS OF A PROTOTYPE FAST KICKER FOR APS MBA UPGRADE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yao, C.-Y.; Morrison, L.; Sun, X.

The APS multi-bend achromatic (MBA) upgrade storage ring plans to support two bunch fill patterns: a 48-bunch and a 324-bunch. A “swap out” injection scheme is required. In order to provide the required kick to injected beam, to minimize the beam loss and residual oscillation of injected beam, and to minimize the perturbation to stored beam during injection, the rise, fall, and flat-top parts of the kicker pulse must be within a 16.9-ns interval. Stripline-type kickers are chosen for both injection and extraction. We developed a prototype kicker that supports a ±15kV differential pulse voltage. We performed high voltage discharge,more » TDR measurement, high voltage pulse test and beam test of the kicker. We report the final design of the fast kicker and the test results.« less

Using the Modified Precursor Method to Estimate the Size of Cycle 24

NASA Technical Reports Server (NTRS)

Wilson, Robert M.; Hathaway, David H.

2008-01-01

Modified geomagnetic precursor techniques for predicting the size of the following sunspot cycle are developed, where these techniques use the 12-month moving averages of the number of disturbed days (when Ap greater than or equals 25), the Ap index, the aa index, and the aaI index at about 4 yr during the declining portion of the preceding sunspot cycle. For cycle 24, these techniques suggest that its RM will measure about 130 +/- 14, a value outside the consensus prediction interval of the low prediction (90 +/- 10) given by the NOAA Solar Cycle 24 Prediction Panel. Furthermore, cycle 24 is predicted to be a fast-rising cycle (ASC = 44 +/- 5 months), peaking before April 2012, presuming the official start of cycle 24 in March 2008. Also discussed are the variation of solar cycle lengths and Hale cycle effects, as related to cycles 23 and 24.

Introduction to special issue: Robert Jay Kastenbaum (1932-2013).

PubMed

Fulton, Robert; Klass, Dennis; Doka, Kenneth J; Kastenbaum, Beatrice

The three pieces in this section introduce the Festschrift celebrating the works and influence of Omega: Journal of Death and Dying's founding editor, Robert Kastenbaum. Robert Fulton, an early Associate Editor of the Journal begins with some personal reflections on Kastenbaum. Klass and Doka then describe the nature of the Festschrift. A closing coda by Robert Kastenbaum's wife, Beatrice Kastenbaum, reminds us of the person behind the work.

Robert Wood Johnson Foundation

MedlinePlus

Robert Wood Johnson Foundation Search How We Work Our Focus Areas About RWJF Search Menu How We Work Grants and Grant ... more For Grantees and Grantseekers The Robert Wood Johnson Foundation funds a wide array of programs which ...

Conferencias a la Memoria de la Dra. Lydia J. Roberts 1967, 1969-1973 (Conferences in Memory of Dr. Lydia J. Roberts 1967, 1969-1973).

ERIC Educational Resources Information Center

Puerto Rico Univ., Rio Piedras.

This publication includes eleven lectures presented as part of a conference given honoring Dr. Lydia J. Roberts. Seven of the papers are written in the English language and four in Spanish. Most of the papers relate to the topic of nutrition, but a few pay tribute to Dr. Roberts in recognition of her distinguished leadership and teacher of human…

Sensitivity of bedside ultrasound and supine anteroposterior chest radiographs for the identification of pneumothorax after blunt trauma.

PubMed

Wilkerson, R Gentry; Stone, Michael B

2010-01-01

Supine anteroposterior (AP) chest radiographs in patients with blunt trauma have poor sensitivity for the identification of pneumothorax. Ultrasound (US) has been proposed as an alternative screening test for pneumothorax in this population. The authors conducted an evidence-based review of the medical literature to compare sensitivity of bedside US and AP chest radiographs in identifying pneumothorax after blunt trauma. MEDLINE and EMBASE databases were searched for trials from 1965 through June 2009 using a search strategy derived from the following PICO formulation of our clinical question: patients included adult (18 + years) emergency department (ED) patients in whom pneumothorax was suspected after blunt trauma. The intervention was thoracic ultrasonography for the detection of pneumothorax. The comparator was the supine AP chest radiograph during the initial evaluation of the patient. The outcome was the diagnostic performance of US in identifying the presence of pneumothorax in the study population. The criterion standard for the presence or absence of pneumothorax was computed tomography (CT) of the chest or a rush of air during thoracostomy tube placement (in unstable patients). Prospective, observational trials of emergency physician (EP)-performed thoracic US were included. Trials in which the exams were performed by radiologists or surgeons, or trials that investigated patients suffering penetrating trauma or with spontaneous or iatrogenic pneumothoraces, were excluded. The methodologic quality of the studies was assessed. Qualitative methods were used to summarize the study results. Data analysis consisted of test performance (sensitivity and specificity, with 95% confidence intervals [CIs]) of thoracic US and supine AP chest radiography. Four prospective observational studies were identified, with a total of 606 subjects who met the inclusion and exclusion criteria. The sensitivity and specificity of US for the detection of pneumothorax ranged from 86% to 98% and 97% to 100%, respectively. The sensitivity of supine AP chest radiographs for the detection of pneumothorax ranged from 28% to 75%. The specificity of supine AP chest radiographs was 100% in all included studies. This evidence-based review suggests that bedside thoracic US is a more sensitive screening test than supine AP chest radiography for the detection of pneumothorax in adult patients with blunt chest trauma. (c) 2010 by the Society for Academic Emergency Medicine.

Exposure to air pollution near a steel plant is associated with reduced heart rate variability: a randomised crossover study.

PubMed

Shutt, Robin H; Kauri, Lisa Marie; Weichenthal, Scott; Kumarathasan, Premkumari; Vincent, Renaud; Thomson, Errol M; Liu, Ling; Mahmud, Mamun; Cakmak, Sabit; Dales, Robert

2017-01-28

Epidemiological studies have shown that as ambient air pollution (AP) increases the risk of cardiovascular mortality also increases. The mechanisms of this effect may be linked to alterations in autonomic nervous system function. We wished to examine the effects of industrial AP on heart rate variability (HRV), a measure of subtle changes in heart rate and rhythm representing autonomic input to the heart. Sixty healthy adults were randomized to spend five consecutive 8-h days outdoors in one of two locations: (1) adjacent to a steel plant in the Bayview neighbourhood in Sault Ste Marie Ontario or (2) at a College campus, several kilometers from the plant. Following a 9-16 day washout period, participants spent five consecutive days at the other site. Ambient AP levels and ambulatory electrocardiogram recordings were collected daily. HRV analysis was undertaken on a segment of the ambulatory ECG recording during a 15 min rest period, near the end of the 8-h on-site day. Standard HRV parameters from both time and frequency domains were measured. Ambient AP was measured with fixed site monitors at both sites. Statistical analysis was completed using mixed-effects models. Compared to the College site, HRV was statistically significantly reduced at the Bayview site by 13% (95%CI 3.6,19.2) for the standard deviation of normal to normal, 8% (95%CI 0.1, 4.9) for the percent normal to normal intervals differing by more than 50 ms, and 15% (95%CI 74.9, 571.2) for low frequency power. Levels of carbon monoxide, sulphur dioxide, nitrogen dioxide, and fine and ultrafine particulates were slightly, but statistically significantly, elevated at Bayview when compared to College. Interquartile range changes in individual air pollutants were significantly associated with reductions in HRV measured on the same day. The patterns of effect showed a high degree of consistency, with nearly all pollutants significantly inversely associated with at least one measure of HRV. The significant associations between AP and changes in HRV suggest that ambient AP near a steel plant may impact autonomic nervous system control of the heart.

Statistical Aspects of X-Class Halo and Non-Halo Events, 1996-2014

NASA Technical Reports Server (NTRS)

Wilson, Robert M.

2016-01-01

Of the 166 X-class events that occurred during the interval 1996-2014, 80 had associations with halo events, 68 had no associations with halo events, and 18 occurred during LASCO (Large Angle and Spectrometric COronagraph) data gaps. Both the duration and location of the X-class halo events proved to be statistically important parameters with respect to the geo-effectiveness of the events. Forty-four of the 80 X-class halo events occurred within 45 degrees of the Sun's central meridian and 47 of the 80 had duration greater than or equal to 30 minutes, whereas only 28 of the 68 X-class non-halo events occurred within 45 degrees of the Sun's central meridian (2 events have unknown location) and 22 of the 68 had duration greater than or equal to 30 minutes. Ignoring the 4 largest X-class flares greater than or equal to X4.0 during the LASCO data gaps, 17 of the remaining 20 were associated with halo events, and 14 of the 17 had at least one geo-magnetically disturbed day (Ap (i.e. NOAA's Ap* (ApStar)index: the major magnetic storms going back to 1932) greater than or equal to 25 nanotesias) within 1-5 days following the X-class halo event. Based on the hourly Dst (Disturbance storm time) index, the most geo-effective X-class halo event during the interval 1996-2014 was that of an X1.7 flare that occurred on 2001 March 29 at 0957, having an hourly Disturbance storm time minimum equal to minus 387 nanotesias. On average, the X-class halo events (80 events) were found to have a mean duration (42 minutes) slightly longer than the mean duration (29 minutes) of the X-class non-halo events (68 events) with the difference in the means being statistically important at the 1 percent level of significance.

Novel Assessment of Renal Motion in Children as Measured via Four-Dimensional Computed Tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pai Panandiker, Atmaram S., E-mail: atmaram.pai-panandiker@stjude.org; Sharma, Shelly; Naik, Mihir H.

Objectives: Abdominal intensity-modulated radiation therapy and proton therapy require quantification of target and organ motion to optimize localization and treatment. Although addressed in adults, there is no available literature on this issue in pediatric patients. We assessed physiologic renal motion in pediatric patients. Methods and Materials: Twenty free-breathing pediatric patients at a median age of 8 years (range, 2-18 years) with intra-abdominal tumors underwent computed tomography simulation and four-dimensional computed tomography acquisition (slice thickness, 3 mm). Kidneys and diaphragms were contoured during eight phases of respiration to estimate center-of-mass motion. We quantified center of kidney mass mobility vectors in threemore » dimensions: anteroposterior (AP), mediolateral (ML), and superoinferior (SI). Results: Kidney motion decreases linearly with decreasing age and height. The 95% confidence interval for the averaged minima and maxima of renal motion in children younger than 9 years was 5-9 mm in the ML direction, 4-11 mm in the AP direction, and 12-25 mm in the SI dimension for both kidneys. In children older than 9 years, the same confidence interval reveals a widening range of motion that was 5-16 mm in the ML direction, 6-17 mm in the AP direction, and 21-52 mm in the SI direction. Although not statistically significant, renal motion correlated with diaphragm motion in older patients. The correlation between diaphragm motion and body mass index was borderline (r = 0.52, p = 0.0816) in younger patients. Conclusions: Renal motion is age and height dependent. Measuring diaphragmatic motion alone does not reliably quantify pediatric renal motion. Renal motion in young children ranges from 5 to 25 mm in orientation-specific directions. The vectors of motion range from 5 to 52 mm in older children. These preliminary data represent novel analyses of pediatric intra-abdominal organ motion.« less

Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis.

PubMed

McHugh, M J; McGorry, P D; Yung, A R; Lin, A; Wood, S J; Hartmann, J A; Nelson, B

2017-03-01

Cannabis use shows a robust dose-dependent relationship with psychosis risk among the general population. Despite this, it has been difficult to link cannabis use with risk for transitioning to a psychotic disorder among individuals at ultra-high risk (UHR) for psychosis. The present study examined UHR transition risk as a function of cannabis use characteristics which vary substantially between individuals including age of first use, cannabis abuse severity and a history of cannabis-induced attenuated psychotic symptoms (APS). Participants were 190 UHR individuals (76 males) recruited at entry to treatment between 2000 and 2006. They completed a comprehensive baseline assessment including a survey of cannabis use characteristics during the period of heaviest use. Outcome was transition to a psychotic disorder, with mean time to follow-up of 5.0 years (range 2.4-8.7 years). A history of cannabis abuse was reported in 58% of the sample. Of these, 26% reported a history of cannabis-induced APS. These individuals were 4.90 (95% confidence interval 1.93-12.44) times more likely to transition to a psychotic disorder (p = 0.001). Greater severity of cannabis abuse also predicted transition to psychosis (p = 0.036). However, this effect was mediated by higher abuse severity among individuals with a history of cannabis-induced APS. Findings suggest that cannabis use poses risk in a subpopulation of UHR individuals who manifest cannabis-induced APS. Whether this reflects underlying genetic vulnerability requires further study. Nevertheless, findings reveal an important early marker of risk with potentially significant prognostic utility for UHR individuals.

Rotational Spectrum, Conformational Composition, Intramolecular Hydrogen Bonding, and Quantum Chemical Calculations of Mercaptoacetonitrile (HSCH2C≡N), a Compound of Potential Astrochemical Interest.

PubMed

Møllendal, Harald; Samdal, Svein; Guillemin, Jean-Claude

2016-03-31

The microwave spectra of mercaptoacetonitrile (HSCH2C≡N) and one deuterated species (DSCH2C≡N) were investigated in the 7.5-124 GHz spectral interval. The spectra of two conformers denoted SC and AP were assigned. The H-S-C-C chain of atoms is synclinal in SC and anti-periplanar in AP. The ground state of SC is split into two substates separated by a comparatively small energy difference resulting in closely spaced transitions with equal intensities. Several transitions of the parent species of SC deviate from Watson's Hamiltonian. Only slight improvements were obtained using a Hamiltonian that takes coupling between the two substates into account. Deviations from Watson's Hamiltonian were also observed for the parent species of AP. However, the spectrum of the deuterated species, which was investigated only for the SC conformer, fits satisfactorily to Watson's Hamiltonian. Relative intensity measurements found SC to be lower in energy than AP by 3.8(3) kJ/mol. The strength of the intramolecular hydrogen bond between the thiol and cyano groups was estimated to be ∼2.1 kJ/mol. The microwave work was augmented by quantum chemical calculations at CCSD and MP2 levels using basis sets of minimum triple-ζ quality. Mercaptoacetonitrile has astrochemical interest, and the spectra presented herein should be useful for a potential identification of this compound in the interstellar medium. Three different ways of generating mercaptoacetonitrile from compounds already found in the interstellar medium were explored by quantum chemical calculations.

Pollen record of the penultimate glacial period in Yuchi Basin, Central Taiwan

NASA Astrophysics Data System (ADS)

Lai, Hsiao-Yin; Liew, Ping-Mei

2010-05-01

Pollen records of the penultimate glacial period are scare not only in Taiwan, but also in East Asia area. Hence, this study intends to provide a new pollen record from a site, Yuchi Basin, in central Taiwan, which may improve our knowledge of the penultimate glacial period. The sediment core, CTN6, was drilled in the northern part of Yuchi Basin. The core is 29.4 m in length and the sampling interval is 10 cm. In total, 86 samples are processed for pollen analysis. Three pollen zones (I,II and III) are determined according to the ratio of arboreal pollens (AP) and non-arboreal pollens (NAP). Because of the scarcity of dating data, pollen assemblages compared with previous pollen records at peripheral areas is utilized to estimate the ages of each pollen zone. AP dominate (60%) Zone I and III, which consist mainly of Cyclobalanopsis-Castanopsis. Thus, Zone I may mark the MIS 5 because of a Cyclobalanopsis-Castanopsis dominant condition. In Zone II, the increase in NAP and pollen of Taxodiaceae and decrease in pollens of Cyclobalanopsis-Castanopsis indicates the penultimate glacial period, i.e. MIS 6. In contrast to the evergreen broadleaved forest found there today, the herbs occupied the basin in Zone II, indicating a relatively dry climate condition than present. Furthermore, during the penultimate glacial period, the climate condition of early part is wetter, evidenced by a higher AP/NAP in Zone IIb. Finally, comparing with the last glacial period in Toushe, we suggest that the penultimate glacial period is drier due to the lower AP/NAP.

Optimal size of stochastic Hodgkin-Huxley neuronal systems for maximal energy efficiency in coding pulse signals

NASA Astrophysics Data System (ADS)

Yu, Lianchun; Liu, Liwei

2014-03-01

The generation and conduction of action potentials (APs) represents a fundamental means of communication in the nervous system and is a metabolically expensive process. In this paper, we investigate the energy efficiency of neural systems in transferring pulse signals with APs. By analytically solving a bistable neuron model that mimics the AP generation with a particle crossing the barrier of a double well, we find the optimal number of ion channels that maximizes the energy efficiency of a neuron. We also investigate the energy efficiency of a neuron population in which the input pulse signals are represented with synchronized spikes and read out with a downstream coincidence detector neuron. We find an optimal number of neurons in neuron population, as well as the number of ion channels in each neuron that maximizes the energy efficiency. The energy efficiency also depends on the characters of the input signals, e.g., the pulse strength and the interpulse intervals. These results are confirmed by computer simulation of the stochastic Hodgkin-Huxley model with a detailed description of the ion channel random gating. We argue that the tradeoff between signal transmission reliability and energy cost may influence the size of the neural systems when energy use is constrained.

Neuropsychiatric Features of a Cohort of Patients with Systemic Lupus Erythematosus

PubMed Central

Moraes-Fontes, Maria Francisca; Lúcio, Isabel; Santos, Céu; Campos, Maria Manuel; Riso, Nuno; Vaz Riscado, Manuel

2012-01-01

In order to establish if neuropsychiatric systemic lupus erythematosus (NPSLE) can be identified by any characteristic other than those used to diagnose the neuropsychiatric (NP) disease itself, we retrospectively reviewed 98 systemic lupus erythematosus (SLE) patients followed over a mean period of 10 years. NPSLE was identified in 22 patients. Stroke and generalized seizures were the most frequent NP manifestations. The NPSLE and non-NPSLE groups were similar with regard to demographic characteristics, ACR criteria, serum autoantibodies, and frequency of hypertension and hypercholesterolemia. Of note, compared to the non-NPSLE group, NPSLE was associated with a higher frequency of smoking (78 versus 26%), organ damage (73 versus 34%), and cumulative mortality rate (14 versus 7%). The series of patients was further analysed according to the presence of antiphospholipid syndrome (APS). Significantly, the interval between the onset of NP disease and SLE diagnosis was shorter in the APS− (0.3 ± 1 years) than in the APS+ (5 ± 7 years) groups. Recurrence and/or persistence of NP events were only documented in the APS− group. Overall cumulative mortality was highest in NPSLE and in APS+ patients with inadequate anticoagulation control, identifying an aspect that requires improved vigilance and the development of novel therapeutic modalities. PMID:23227358

Musical and linguistic listening modes in the speech-to-song illusion bias timing perception and absolute pitch memory.

PubMed

Graber, Emily; Simchy-Gross, Rhimmon; Margulis, Elizabeth Hellmuth

2017-12-01

The speech-to-song (STS) illusion is a phenomenon in which some spoken utterances perceptually transform to song after repetition [Deutsch, Henthorn, and Lapidis (2011). J. Acoust. Soc. Am. 129, 2245-2252]. Tierney, Dick, Deutsch, and Sereno [(2013). Cereb. Cortex. 23, 249-254] developed a set of stimuli where half tend to transform to perceived song with repetition and half do not. Those that transform and those that do not can be understood to induce a musical or linguistic mode of listening, respectively. By comparing performance on perceptual tasks related to transforming and non-transforming utterances, the current study examines whether the musical mode of listening entails higher sensitivity to temporal regularity and better absolute pitch (AP) memory compared to the linguistic mode. In experiment 1, inter-stimulus intervals within STS trials were steady, slightly variable, or highly variable. Participants reported how temporally regular utterance entrances were. In experiment 2, participants performed an AP memory task after a blocked STS exposure phase. Utterances identically matching those used in the exposure phase were targets among transposed distractors in the test phase. Results indicate that listeners exhibit heightened awareness of temporal manipulations but reduced awareness of AP manipulations to transforming utterances. This methodology establishes a framework for implicitly differentiating musical from linguistic perception.

Optimal size of stochastic Hodgkin-Huxley neuronal systems for maximal energy efficiency in coding pulse signals.

PubMed

Yu, Lianchun; Liu, Liwei

2014-03-01

The generation and conduction of action potentials (APs) represents a fundamental means of communication in the nervous system and is a metabolically expensive process. In this paper, we investigate the energy efficiency of neural systems in transferring pulse signals with APs. By analytically solving a bistable neuron model that mimics the AP generation with a particle crossing the barrier of a double well, we find the optimal number of ion channels that maximizes the energy efficiency of a neuron. We also investigate the energy efficiency of a neuron population in which the input pulse signals are represented with synchronized spikes and read out with a downstream coincidence detector neuron. We find an optimal number of neurons in neuron population, as well as the number of ion channels in each neuron that maximizes the energy efficiency. The energy efficiency also depends on the characters of the input signals, e.g., the pulse strength and the interpulse intervals. These results are confirmed by computer simulation of the stochastic Hodgkin-Huxley model with a detailed description of the ion channel random gating. We argue that the tradeoff between signal transmission reliability and energy cost may influence the size of the neural systems when energy use is constrained.

NF-Y Binding Site Architecture Defines a C-Fos Targeted Promoter Class

PubMed Central

Haubrock, Martin; Hartmann, Fabian; Wingender, Edgar

2016-01-01

ChIP-seq experiments detect the chromatin occupancy of known transcription factors in a genome-wide fashion. The comparisons of several species-specific ChIP-seq libraries done for different transcription factors have revealed a complex combinatorial and context-specific co-localization behavior for the identified binding regions. In this study we have investigated human derived ChIP-seq data to identify common cis-regulatory principles for the human transcription factor c-Fos. We found that in four different cell lines, c-Fos targeted proximal and distal genomic intervals show prevalences for either AP-1 motifs or CCAAT boxes as known binding motifs for the transcription factor NF-Y, and thereby act in a mutually exclusive manner. For proximal regions of co-localized c-Fos and NF-YB binding, we gathered evidence that a characteristic configuration of repeating CCAAT motifs may be responsible for attracting c-Fos, probably provided by a nearby AP-1 bound enhancer. Our results suggest a novel regulatory function of NF-Y in gene-proximal regions. Specific CCAAT dimer repeats bound by the transcription factor NF-Y define this novel cis-regulatory module. Based on this behavior we propose a new enhancer promoter interaction model based on AP-1 motif defined enhancers which interact with CCAAT-box characterized promoter regions. PMID:27517874

Dose evaluation in paediatric patients undergoing chest X-ray examinations

NASA Astrophysics Data System (ADS)

Piantini, F.; Schelin, H. R.; Denyak, V.; Bunick, A. P.; Legnani, A.; Ledesma, J. A.; Filipov, D.; Paschuk, S. A.

2017-11-01

This study aimed to estimate the incident air kerma in chest X-ray examinations, for lateral (LAT) and anterior-posterior (AP) (together with posterior-anterior (PA)) projections, in one of the largest paediatric hospitals in Brazil, and to compare these with the results obtained in a general hospital of the same city. The dosimetric results were analysed along with the patient characteristics and radiographer strategies. The examinations of 225 (119 male and 106 female) patients were studied and 389 X-ray scans (200 AP/PA projections and 189 LAT projections) of paediatric patients were acquired. For analysis of the results, the patients were divided into the following age groups: 0-1 y, 1-5 y, 5-10 y, and 10-15 y. Patient's thickness can be determined from age, height or weight with an uncertainty of 20-30%. In different hospitals, the difference in patient's thicknesses between the same age groups can reach 25-55%. A minimal correlation between the patient dose and thickness was observed, with a 4-fold difference in the dose for patients of the same thickness. By standardizing radiological protocols, it should be possible to keep the dose within intervals of 50-100 μGy for LAT projection and 40-80 μGy for AP/PA projection.

A young patient with atypical type-B Wolff–Parkinson–White syndrome accompanied by left ventricular dysfunction

PubMed Central

Takeuchi, Takahiro; Tomita, Takeshi; Kasai, Hiroki; Kashiwagi, Daisuke; Yoshie, Koji; Yaguchi, Tomonori; Oguchi, Yasutaka; Kozuka, Ayako; Gautam, Milan; Motoki, Hirohiko; Okada, Ayako; Shiba, Yuji; Aizawa, Kazunori; Izawa, Atsushi; Miyashita, Yusuke; Koyama, Jun; Hongo, Minoru; Ikeda, Uichi

2014-01-01

A 15-year-old asymptomatic male patient presented with an electrocardiographic abnormality and left ventricular (LV) dysfunction (left ventricle ejection fraction of 40%) in a physical examination performed 2 years previously. LV dysfunction did not improve despite optimal medical therapy for dilated cardiomyopathy. Twelve-lead electrocardiography revealed a normal PR interval (138 ms) with a small delta-like wave in V2, but not a typical diagnostic wave that could be diagnosed as Wolff–Parkinson–White (WPW) syndrome by an electrocardiogram auto-analysis. Transthoracic echocardiography showed a remarkable asynchronous septal motion. An electrophysiological study was performed to exclude WPW syndrome. An accessory pathway (AP) was revealed on the lateral wall of the right ventricle, and radiofrequency catheter ablation was successfully performed to disconnect the AP. Thereafter, the dyssynchrony disappeared, and LV function improved. The intrinsic atrioventricular nodal conduction was very slow (A-H, 237 ms). The results of electrocardiogram auto-analysis could not be used to confirm the diagnosis of WPW syndrome because of the atypical delta wave. Conduction via the right lateral AP caused electrical dyssynchrony in the LV. This case suggests that atypical delta waves should be evaluated without depending on electrocardiographic auto-analyses in patients with LV dysfunction accompanied by dyssynchrony. PMID:26336525

77 FR 44679 - Suntron Corporation, Including On-Site Leased Workers From Manpower, Nesco, TPI and Robert Half...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... workers leased from NESCO, TPI, and Robert Half working on-site at the Sugarland, Texas location of the... Suntron Corporation, including on-site leased workers from Manpower, NESCO, TPI, and Robert Half, Sugar...

Comparative sonographic evaluation of the anteroposterior dimensions of the pancreas in diabetics and nondiabetics.

PubMed

Agabi, J O; Akhigbe, A O

2016-01-01

The pancreas is an insulin-producing gland and is prone to varying degrees of destruction and change in patients with diabetes mellitus (DM). Various morphological changes including reduction in the pancreas dimensions have been described in DM. To determine pancreatic anteroposterior (AP) dimensions in diabetics by sonography and compare with nondiabetics. To also evaluate the correlation of the AP dimensions with patient's anthropometry, as well as the duration of the disease in comparison with nondiabetics. This is a comparative cross-sectional study involving 150 diabetics with 150 sex and age matched healthy normoglycemic group used as controls. Sonographic measurements of the AP dimensions of the pancreatic head, body, and tail of both study groups were performed with the use of 3.5 MHz curvilinear array transducer of a SonoAce X4 ultrasound machine. Data were analyzed using Statistical Package for Social Sciences version 17 (SPSS Inc., Chicago, IL, USA). A statistical test was considered significant at P ≤ 0.05 and 95% confidence interval. Pancreas AP dimensions were significantly smaller in diabetics compared to those of the controls. The mean dimensions were 1.91 ± 0.26 cm, 0.95 ± 0.12 cm, and 0.91 ± 0.11 cm for the head, body, and tail, respectively, in diabetics and 2.32 ± 0.22 cm, 1.43 ± 0.19 cm, and 1.34 ± 0.20 cm in the control (P < 0.001 in all cases). The dimensions were also significantly smaller in the Type 1 diabetics compared to Type 2 (P < 0.001 in all cases). The mean duration of illness for the Types 1 and 2 diabetics were 3.09 ± 1.38 and 3.78 ± 3.12 years, respectively. Longer duration of illness was associated with smaller pancreas body and tail dimensions, while pancreas head dimension was not significantly affected by the duration of illness. Diabetics have smaller pancreas AP dimensions compared to the normal population.

What Pertussis Mortality Rates Make Maternal Acellular Pertussis Immunization Cost-Effective in Low- and Middle-Income Countries? A Decision Analysis

PubMed Central

Russell, Louise B.; Pentakota, Sri Ram; Toscano, Cristiana Maria; Cosgriff, Ben; Sinha, Anushua

2016-01-01

Background. Despite longstanding infant vaccination programs in low- and middle-income countries (LMICs), pertussis continues to cause deaths in the youngest infants. A maternal monovalent acellular pertussis (aP) vaccine, in development, could prevent many of these deaths. We estimated infant pertussis mortality rates at which maternal vaccination would be a cost-effective use of public health resources in LMICs. Methods. We developed a decision model to evaluate the cost-effectiveness of maternal aP immunization plus routine infant vaccination vs routine infant vaccination alone in Bangladesh, Nigeria, and Brazil. For a range of maternal aP vaccine prices, one-way sensitivity analyses identified the infant pertussis mortality rates required to make maternal immunization cost-effective by alternative benchmarks ($100, 0.5 gross domestic product [GDP] per capita, and GDP per capita per disability-adjusted life-year [DALY]). Probabilistic sensitivity analysis provided uncertainty intervals for these mortality rates. Results. Infant pertussis mortality rates necessary to make maternal aP immunization cost-effective exceed the rates suggested by current evidence except at low vaccine prices and/or cost-effectiveness benchmarks at the high end of those considered in this report. For example, at a vaccine price of $0.50/dose, pertussis mortality would need to be 0.051 per 1000 infants in Bangladesh, and 0.018 per 1000 in Nigeria, to cost 0.5 per capita GDP per DALY. In Brazil, a middle-income country, at a vaccine price of $4/dose, infant pertussis mortality would need to be 0.043 per 1000 to cost 0.5 per capita GDP per DALY. Conclusions. For commonly used cost-effectiveness benchmarks, maternal aP immunization would be cost-effective in many LMICs only if the vaccine were offered at less than $1–$2/dose. PMID:27838677

Experimental, Pathologic, and Clinical Findings of Radiofrequency Catheter Ablation of Para-Hisian Region From the Right Ventricle in Dogs and Humans.

PubMed

Xue, Yumei; Zhan, Xianzhang; Wu, Shulin; Wang, Hongyue; Liu, Yang; Liao, Zili; Deng, Hai; Duan, Xuejing; Zeng, Shaoying; Liang, Dongpo; Elvan, Arif; Fang, Xianhong; Liao, Hongtao; Ramdat Misier, Anand R; Smit, Jaap Jan J; Metzner, Andreas; Heeger, Christian-Hendrik; Liu, Fangzhou; Wang, Feng; Zhang, Zhiwei; Kuck, Karl-Heinz; Yen Ho, Siew; Ouyang, Feifan

2017-06-01

Ablation of para-Hisian accessory pathway (AP) poses high risks of atrioventricular block. We developed a pacing technique to differentiate the near-field (NF) from far-field His activations to avoid the complication. Three-dimensional mapping of the right ventricle was performed in 15 mongrel dogs and 23 patients with para-Hisian AP. Using different pacing outputs, the NF- and far-field His activation was identified on the ventricular aspect. Radiofrequency application was delivered at the NF His site in 8 (group 1) and the far-field His site in 7 dogs (group 2), followed by pathologic examination after 14 days. NF His activation was captured with 5 mA/1 ms in 10 and 10 mA/1 ms in 5 dogs. In group 1, radiofrequency delivery resulted in complete atrioventricular block in 3, right bundle branch block with HV (His-to-ventricular) interval prolongation in 1, and only right bundle branch block in 2 dogs, whereas no changes occurred in group 2. Pathologic examination in group-1 dogs showed complete or partial necrosis of the His bundle in 4 and complete necrosis of the right bundle branch in 5 dogs. In group 2, partial necrosis in the right bundle branch was found only in 1 dog. Using this pacing technique, the APs were 5.7±1.2 mm away from the His bundle located superiorly in 20 or inferiorly in 3 patients. All APs were successfully eliminated with 1 to 3 radiofrequency applications. No complications and recurrence occurred during a follow-up of 11.8±1.4 months. Differentiating the NF His from far-field His activations led to a high ablation success without atrioventricular block in para-Hisian AP patients. © 2017 American Heart Association, Inc.

The Sojourn Time in a Three Node, Acyclic, Jackson Queueing Network.

DTIC Science & Technology

1982-01-27

Effect of Intermediate Storage on Production Lines with Dependent Machines, Robert D. Foley and Petcharat Chansaenwilai 8015 Some Conditions for the...Queues, Robert D. Foley 8105 Reversibility of Production Lines with Dependent Machines, Petcharat Chansaenwilai 1 8106 Queues with Delayed Feedback, Robert

Editorial: Plant organ abscission: from models to crops

USDA-ARS?s Scientific Manuscript database

The shedding of plant organs is a highly coordinated process essential for both vegetative and reproductive development (Addicott, 1982; Sexton and Roberts, 1982; Roberts et al., 2002; Leslie et al., 2007; Roberts and Gonzalez-Carranza, 2007; Estornell et al., 2013). Research with model plants, name...

Assessment of the radioanatomic positioning of the osteoarthritic knee in serial radiographs: comparison of three acquisition techniques.

PubMed

Le Graverand, M-P H; Mazzuca, S; Lassere, M; Guermazi, A; Pickering, E; Brandt, K; Peterfy, C; Cline, G; Nevitt, M; Woodworth, T; Conaghan, P; Vignon, E

2006-01-01

Recent studies using various standardized radiographic acquisition techniques have demonstrated the necessity of reproducible radioanatomic alignment of the knee to assure precise measurements of medial tibiofemoral joint space width (JSW). The objective of the present study was to characterize the longitudinal performance of several acquisition techniques with respect to long-term reproducibility of positioning of the knee, and the impact of changes in positioning on the rate and variability of joint space narrowing (JSN). Eighty subjects were randomly selected from each of three cohorts followed in recent studies of the radiographic progression of knee osteoarthritis (OA): the Health ABC study (paired fixed-flexion [FF] radiographs taken at a 36-month interval); the Glucosamine Arthritis Intervention Trial (GAIT) (paired metatarsophalangeal [MTP] radiographs obtained at a 12-month interval), and a randomized clinical trial of doxycycline (fluoroscopically assisted semiflexed anteroposterior (AP) radiographs taken at a 16-month interval). Manual measurements were obtained from each radiograph to represent markers of radioanatomic positioning of the knee (alignment of the medial tibial plateau and X-ray beam, knee rotation, femorotibial angle) and to evaluate minimum JSW (mJSW) in the medial tibiofemoral compartment. The effects on the mean annualized rate of JSN and on the variability of that rate of highly reproduced vs variable positioning of the knee in serial radiographs were evaluated. Parallel or near-parallel alignment was achieved significantly more frequently with the fluoroscopically guided positioning used in the semiflexed AP protocol than with either the non-fluoroscopic FF or MTP protocol (68% vs 14% for both FF and MTP protocols when measured at the midpoint of the medial compartment; 75% vs 26% and 34% for the FF and MTP protocols, respectively, when measured at the site of mJSW; P<0.001 for each). Knee rotation was reproduced more frequently in semiflexed AP radiographs than in FF radiographs (66% vs 45%, P<0.01). In contrast, the FF technique yielded a greater proportion of paired radiographs in which the femorotibial angle was accurately reproduced than the semiflexed AP or MTP protocol (78% vs 59% and 56%, respectively, P<0.01 for each). Notably, only paired radiographs with parallel or near-parallel alignment exhibited a mean rate of JSN (+/-SD) in the OA knee that was more rapid and less variable than that measured in all knees (0.186+/-0.274 mm/year, standardized response to mean [SRM]=0.68 vs 0.128+/-0.291 mm/year, SRM=0.44). This study confirms the importance of parallel radioanatomic alignment of the anterior and posterior margins of the medial tibial plateau in detecting JSN in subjects with knee OA. The use of radiographic methods that assure parallel alignment during serial X-ray examinations will permit the design of more efficient studies of biomarkers of OA progression and of structure modification in knee OA.

A Failure in Strategy: America and the Vietnam War 1965-1968

DTIC Science & Technology

2001-04-01

5 Robert S. McNamara, Argument Without End : In Search of Answers to the Vietnam Tragedy (New...McNamara, Robert S. Argument Without End : In Search of Answers to the Vietnam Tragedy . New York: Public Affairs, 1999. McNamara, Robert S. In Retrospect

Periodic spectrum variations in helium-rich stars

NASA Technical Reports Server (NTRS)

Walborn, N. R.

1982-01-01

Spectroscopic observations of four helium-rich stars are presented. In HD 37776, antiphase variations of Si III and He I have been found, which represent another point of similarity to the Ap phenomenon. The remarkable H-alpha emission variations in Sigma Ori E are illustrated with uniform phase coverage, and strict periodicity over a five-year interval is shown. A radial-velocity study of HD 64740 shows constancy to within the accuracy of the observations. Finally, Delta Ori B is confirmed as a helium-rich star.

Synthesis and characterization of polypyrrole grafted chitin

NASA Astrophysics Data System (ADS)

Ramaprasad, A. T.; Latha, D.; Rao, Vijayalakshmi

2017-05-01

Synthesis and characterization of chitin grafted with polypyrrole (PPy) is reported in this paper. Chitin is soaked in pyrrole solution of various concentrations for different time intervals and polymerized using ammonium peroxy disulphate (APS) as an initiator. Grafting percentage of polypyrrole onto chitin is calculated from weight of chitin before and after grafting. Grafting of polymer is further verified by dissolution studies. The grafted polymer samples are characterized by FTIR, UV-Vis absorption spectrum, XRD, DSC, TGA, AFM, SEM and conductivity studies.

75 FR 49950 - Robert Wayne Mosier, D.O.; Denial of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Wayne Mosier, D.O.; Denial of... Enforcement Administration, issued an Order to Show Cause to Robert Wayne Mosier, D.O. (Respondent), of... Osteopathic Examiners v. R. Wayne Mosier, D.O., No. 0712-0001 (June 18, 2009). Respondent also held an...

78 FR 2391 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RP13-436-000] CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and Electric Company... Energy Regulatory Commission (FERC); CAlifornians for Renewable Energy, Inc., Michael E. Boyd, and Robert...

76 FR 7837 - Ryan, Robert M.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6466-000] Ryan, Robert M.; Notice of Filing Take notice that on December 31, 2010, Robert M. Ryan submitted for filing, [email protected] , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5 p.m...

1. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic Stone Architecture of Winterset, Iowa, Prior to and During the Civil War Period.' Ames, IA: Iowa State University, 1960) Robert R. Harvey, delineator 1960 FLOOR PLAN, ORIGINAL HOUSE ('FIGURE 3-A') - Caleb Clark House, 814 South Eighth Street, Winterset, Madison County, IA

Embracing the Humanistic Vision: Recurrent Themes in Peter Roberts' Recent Writings

ERIC Educational Resources Information Center

Reveley, James

2018-01-01

Running like a leitmotif through Peter Roberts' recently published philosophico-educational writings there is a humanistic thread, which this article picks out. In order to ascertain the quality of this humanism, Roberts is positioned in relation to a pair of extant humanisms: radical and integral. Points of comparability and contrast are…

76 FR 54240 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

...: Robert G. Keefe, PhD, Scientific Review Officer, Scientific Review Program, DEA/NIAID/NIH/DHHS, Room 3256... Conference Call). Contact Person: Robert G. Keefe, PhD, Scientific Review Officer, Scientific Review Program... Drive, Bethesda, MD 20817 (Telephone Conference Call). Contact Person: Robert G. Keefe, PhD, Scientific...

DefenseLink.mil - Special Report - Travels With Gates

Science.gov Websites

of Estonia Estonia Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates walks with the Prime Minister of Estonia Andrus

Delivering Higher Education to Adults: An Interview with Robert Mendenhall

ERIC Educational Resources Information Center

Finney, Joni E.

2012-01-01

This article presents an interview with Robert Mendenhall, president of Western Governors University, who is the 2012 recipient of the Virginia B. Smith (VBS) Innovative Leadership Award. The annual award recognizes his leadership in redesigning higher education delivery for adult students. In the interview, Robert Mendenhall talks about his work…

Skull Size and Intelligence, and King Robert Bruce's IQ

ERIC Educational Resources Information Center

Deary, Ian J.; Ferguson, Karen J.; Bastin, Mark E.; Barrow, Geoffrey W. S.; Reid, Louise M.; Seckl, Jonathan R.; Wardlaw, Joanna M.; MacLullich, Alasdair M. J.

2007-01-01

An estimate of someone's IQ is a potentially informative personal datum. This study examines the association between external skull measurements and IQ scores, and uses the resulting regression equation to provide an estimate of the IQ of King Robert I of Scotland (Robert Bruce, 1274-1329). Participants were 48 relatively healthy Caucasian men…

Robert Gilmore, a portrait

NASA Astrophysics Data System (ADS)

Solari, Hernán G.

2013-01-01

To present the personality of Bob Gilmore is a formidable task, as his scientific contributions include group theory, laser physics, non-linear dynamics, catastrophe theory, thermodynamics, dynamical systems, quantum theory and more. But even if we succeed in describing his contributions, much of Gilmore's being would be lost. Bob as advisor, Bob as father, Bob as teacher, Bob as scientific communicator reveal as much of Bob Gilmore as his scientific papers and his books. Very much as in the Group Theory so close to him, there is a Robert Gilmore in abstract as well as representations of Robert Gilmore. We will make an attempt to find the "principle of the rule", the abstract level of Robert Gilmore as well as Robert Gilmore, himself, as a representation of the duality science-humanism.

Ethnic analogies and differences in fetal heart rate variability signal: A retrospective study.

PubMed

Tagliaferri, Salvatore; Esposito, Francesca Giovanna; Fagioli, Rosa; Di Cresce, Marco; Sacchi, Lucia; Signorini, Maria Gabriella; Campanile, Marta; Martinelli, Pasquale; Magenes, Giovanni

2017-02-01

We aimed to analyze computerized cardiotocographic (cCTG) parameters (including fetal heart rate baseline, short-term variability, Delta, long-term irregularity [LTI], interval index [II], low frequency [LF], movement frequency [MF], high frequency [HF], and approximate entropy [ApEn]) in physiological term pregnancies in order to correlate them with ethnic differences. The clinical meaning of numerical parameters may explain physiological or paraphysiological phenomena that occur in fetuses of different ethnic origins. A total of 696 pregnant women, including 384 from Europe, 246 from sub-Saharan Africa, 45 from South-East Asia, and 21 from South America, were monitored from the 37th to the 41st week of gestation. Statistical analysis was performed with the analysis of variance test, Pearson correlation test and receiver-operator curves (P < 0.05). Our results showed statistically significant differences (P < 0.05) between white and black women for Delta, LTI, LF, MF, HF, and ApEn; between white and Asian women for Delta, LTI, MF, and the LF/(HF + MF) ratio; and between white and Latina women for Delta, LTI, and ApEn. In particular, Delta and LTI performed better in the white group than in the black, Asian, and Latina groups. Instead, LF, MF, HF, and ApEn performed better in the black than in the white group. Our results confirmed the integrity and normal functionality of both central and autonomic nervous system components for all fetuses investigated. Therefore, CTG monitoring should include both linear and nonlinear components of fetal heart rate variability in order to avoid misinterpretations of the CTG trace among ethnic groups. © 2016 Japan Society of Obstetrics and Gynecology.

Pharmacokinetics and pharmacodynamics of a new reformulated microemulsion and the long-chain triglyceride emulsion of propofol in beagle dogs

PubMed Central

Lee, S-H; Ghim, J-L; Song, M-H; Choi, H-G; Choi, B-M; Lee, H-M; Lee, E-K; Roh, Y-J; Noh, G-J

2009-01-01

Background and purpose: Microemulsion propofol was developed to eliminate lipid solvent-related adverse events of long-chain triglyceride emulsion (LCT) propofol. We compared dose proportionality, pharmacokinetic and pharmacodynamic characteristics of both formulations. Experimental approach: The study was a randomized, two-period and crossover design with 7-day wash-out period. Microemulsion and LCT propofol were administered by zero-order infusion (0.75, 1.00 and 1.25 mg·kg−1·min−1) for 20 min in 30 beagle dogs (male/female = 5/5 for each rate). Arterial samples were collected at preset intervals. The electroencephalographic approximate entropy (ApEn) was used as a measure of propofol effect. Dose proportionality, pharmacokinetic and pharmacodynamic bioequivalence were evaluated by non-compartmental analyses. Population analysis was performed using nonlinear mixed effects modelling. Key results: Both formulations showed dose proportionality at the applied dose range. The ratios of geometric means of AUClast and AUCinf between both formulations were acceptable for bioequivalence, whereas that of Cmax was not. The pharmacodynamic bioequivalence was indicated by the arithmetic means of AAC (areas above the ApEn time curves) and E0 (baseline ApEn)–Emax (maximally decreased ApEn) between both formulations. The pharmacokinetics of both formulations were best described by three compartment models. Body weight was a significant covariate for V1 of both formulations and sex for k21 of microemulsion propofol. The blood-brain equilibration rate constants (ke0, min−1) were 0.476 and 0.696 for microemulsion and LCT propofol respectively. Conclusions and implications: Microemulsion propofol was pharmacodynamically bioequivalent to LCT propofol although pharmacokinetic bioequivalence was incomplete, and demonstrated linear pharmacokinetics at the applied dose ranges. PMID:19925493

Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study

PubMed Central

Eze, Ikenna C; Foraster, Maria; Schaffner, Emmanuel; Vienneau, Danielle; Héritier, Harris; Rudzik, Franziska; Thiesse, Laurie; Pieren, Reto; Imboden, Medea; von Eckardstein, Arnold; Schindler, Christian; Brink, Mark; Cajochen, Christian; Wunderli, Jean-Marc; Röösli, Martin; Probst-Hensch, Nicole

2017-01-01

Abstract Background Epidemiological studies have inconsistently linked transportation noise and air pollution (AP) with diabetes risk. Most studies have considered single noise sources and/or AP, but none has investigated their mutually independent contributions to diabetes risk. Methods We investigated 2631 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), without diabetes in 2002 and without change of residence between 2002 and 2011. Using questionnaire and biomarker data, incident diabetes cases were identified in 2011. Noise and AP exposures in 2001 were assigned to participants’ residences (annual average road, railway or aircraft noise level during day-evening-night (Lden), total night number of noise events, intermittency ratio (temporal variation as proportion of event-based noise level over total noise level) and nitrogen dioxide (NO2) levels. We applied mixed Poisson regression to estimate the relative risk (RR) of diabetes and their 95% confidence intervals (CI) in mutually-adjusted models. Results Diabetes incidence was 4.2%. Median [interquartile range (IQR)] road, railway, aircraft noise and NO2 were 54 (10) dB, 32 (11) dB, 30 (12) dB and 21 (15) μg/m3, respectively. Lden road and aircraft were associated with incident diabetes (respective RR: 1.35; 95% CI: 1.02–1.78 and 1.86; 95% CI: 0.96–3.59 per IQR) independently of Lden railway and NO2 (which were not associated with diabetes risk) in mutually adjusted models. We observed stronger effects of Lden road among participants reporting poor sleep quality or sleeping with open windows. Conclusions Transportation noise may be more relevant than AP in the development of diabetes, potentially acting through noise-induced sleep disturbances. PMID:28338949

Randomized trial of a dual-hormone artificial pancreas with dosing adjustment during exercise compared with no adjustment and sensor-augmented pump therapy.

PubMed

Jacobs, P G; El Youssef, J; Reddy, R; Resalat, N; Branigan, D; Condon, J; Preiser, N; Ramsey, K; Jones, M; Edwards, C; Kuehl, K; Leitschuh, J; Rajhbeharrysingh, U; Castle, J R

2016-11-01

To test whether adjusting insulin and glucagon in response to exercise within a dual-hormone artificial pancreas (AP) reduces exercise-related hypoglycaemia. In random order, 21 adults with type 1 diabetes (T1D) underwent three 22-hour experimental sessions: AP with exercise dosing adjustment (APX); AP with no exercise dosing adjustment (APN); and sensor-augmented pump (SAP) therapy. After an overnight stay and 2 hours after breakfast, participants exercised for 45 minutes at 60% of their maximum heart rate, with no snack given before exercise. During APX, insulin was decreased and glucagon was increased at exercise onset, while during SAP therapy, subjects could adjust dosing before exercise. The two primary outcomes were percentage of time spent in hypoglycaemia (<3.9 mmol/L) and percentage of time spent in euglycaemia (3.9-10 mmol/L) from the start of exercise to the end of the study. The mean (95% confidence interval) times spent in hypoglycaemia (<3.9 mmol/L) after the start of exercise were 0.3% (-0.1, 0.7) for APX, 3.1% (0.8, 5.3) for APN, and 0.8% (0.1, 1.4) for SAP therapy. There was an absolute difference of 2.8% less time spent in hypoglycaemia for APX versus APN (p = .001) and 0.5% less time spent in hypoglycaemia for APX versus SAP therapy (p = .16). Mean time spent in euglycaemia was similar across the different sessions. Adjusting insulin and glucagon delivery at exercise onset within a dual-hormone AP significantly reduces hypoglycaemia compared with no adjustment and performs similarly to SAP therapy when insulin is adjusted before exercise. © 2016 John Wiley & Sons Ltd.

Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study.

PubMed

Eze, Ikenna C; Foraster, Maria; Schaffner, Emmanuel; Vienneau, Danielle; Héritier, Harris; Rudzik, Franziska; Thiesse, Laurie; Pieren, Reto; Imboden, Medea; von Eckardstein, Arnold; Schindler, Christian; Brink, Mark; Cajochen, Christian; Wunderli, Jean-Marc; Röösli, Martin; Probst-Hensch, Nicole

2017-08-01

Epidemiological studies have inconsistently linked transportation noise and air pollution (AP) with diabetes risk. Most studies have considered single noise sources and/or AP, but none has investigated their mutually independent contributions to diabetes risk. We investigated 2631 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), without diabetes in 2002 and without change of residence between 2002 and 2011. Using questionnaire and biomarker data, incident diabetes cases were identified in 2011. Noise and AP exposures in 2001 were assigned to participants' residences (annual average road, railway or aircraft noise level during day-evening-night (Lden), total night number of noise events, intermittency ratio (temporal variation as proportion of event-based noise level over total noise level) and nitrogen dioxide (NO2) levels. We applied mixed Poisson regression to estimate the relative risk (RR) of diabetes and their 95% confidence intervals (CI) in mutually-adjusted models. Diabetes incidence was 4.2%. Median [interquartile range (IQR)] road, railway, aircraft noise and NO2 were 54 (10) dB, 32 (11) dB, 30 (12) dB and 21 (15) μg/m3, respectively. Lden road and aircraft were associated with incident diabetes (respective RR: 1.35; 95% CI: 1.02-1.78 and 1.86; 95% CI: 0.96-3.59 per IQR) independently of Lden railway and NO2 (which were not associated with diabetes risk) in mutually adjusted models. We observed stronger effects of Lden road among participants reporting poor sleep quality or sleeping with open windows. Transportation noise may be more relevant than AP in the development of diabetes, potentially acting through noise-induced sleep disturbances. © The Author 2017. Published by Oxford University Press on behalf of the International Epidemiological Association

Calcium transient dynamics and the mechanisms of ventricular vulnerability to single premature electrical stimulation in Langendorff-perfused rabbit ventricles

PubMed Central

Hayashi, Hideki; Kamanu, Santosh Dora; Ono, Norihiko; Kawase, Ayaka; Chou, Chung-Chuan; Weiss, James N.; Karagueuzian, Hrayr S.; Lin, Shien-Fong; Chen, Peng-Sheng

2009-01-01

BACKGROUND Single strong premature electrical stimulation (S2) may induce figure-eight reentry. We hypothesize that Ca current-mediated slow-response action potentials (APs) play a key role in the propagation in the central common pathway (CCP) of the reentry. METHODS We simultaneously mapped optical membrane potential (Vm) and intracellular Ca (Cai) transients in isolated Langendorff-perfused rabbit ventricles. Baseline pacing (S1) and a cathodal S2 (40 – 80 mA) were given at different epicardial sites with a coupling interval of 135 ± 20 ms. RESULTS In all 6 hearts, S2 induced graded responses around the S2 site. These graded responses propagated locally toward the S1 site and initiated fast APs from recovered tissues. The wavefront then circled around the refractory tissue near the site of S2. At the side of S2 opposite to the S1, the graded responses prolonged AP duration while the Cai continued to decline, resulting in a Cai sinkhole (an area of low Cai). The Cai in the sinkhole then spontaneously increased, followed by a slow Vm depolarization with a take-off potential of −40 ± 3.9 mV, which was confirmed with microelectrode recordings in 3 hearts. These slow-response APs then propagated through CCP to complete a figure-eight reentry. CONCLUSION We conclude that a strong premature stimulus can induce a Cai sinkhole at the entrance of the CCP. Spontaneous Cai elevation in the Cai sinkhole precedes the Vm depolarization, leading to Ca current-mediated slow propagation in the CCP. The slow propagation allows more time for tissues at the other side of CCP to recover and be excited to complete figure-eight reentry. PMID:18180025

Calcium transient dynamics and the mechanisms of ventricular vulnerability to single premature electrical stimulation in Langendorff-perfused rabbit ventricles.

PubMed

Hayashi, Hideki; Kamanu, Santosh Dora; Ono, Norihiko; Kawase, Ayaka; Chou, Chung-Chuan; Weiss, James N; Karagueuzian, Hrayr S; Lin, Shien-Fong; Chen, Peng-Sheng

2008-01-01

Single strong premature electrical stimulation (S(2)) may induce figure-eight reentry. We hypothesize that Ca current-mediated slow-response action potentials (APs) play a key role in the propagation in the central common pathway (CCP) of the reentry. We simultaneously mapped optical membrane potential (V(m)) and intracellular Ca (Ca(i)) transients in isolated Langendorff-perfused rabbit ventricles. Baseline pacing (S(1)) and a cathodal S(2) (40-80 mA) were given at different epicardial sites with a coupling interval of 135 +/- 20 ms. In all 6 hearts, S(2) induced graded responses around the S(2) site. These graded responses propagated locally toward the S(1) site and initiated fast APs from recovered tissues. The wavefront then circled around the refractory tissue near the site of S(2). At the side of S(2) opposite to the S(1), the graded responses prolonged AP duration while the Ca(i) continued to decline, resulting in a Ca(i) sinkhole (an area of low Ca(i)). The Ca(i) in the sinkhole then spontaneously increased, followed by a slow V(m) depolarization with a take-off potential of -40 +/- 3.9 mV, which was confirmed with microelectrode recordings in 3 hearts. These slow-response APs then propagated through CCP to complete a figure-eight reentry. We conclude that a strong premature stimulus can induce a Ca(i) sinkhole at the entrance of the CCP. Spontaneous Ca(i) elevation in the Ca(i) sinkhole precedes the V(m) depolarization, leading to Ca current-mediated slow propagation in the CCP. The slow propagation allows more time for tissues at the other side of CCP to recover and be excited to complete figure-eight reentry.

Noninvasive Localization of Accessory Pathways in Patients with Wolff-Parkinson-White Syndrome: A Strain Imaging Study

PubMed Central

Esmaeilzadeh, Maryam; Omran, Mohammad Taghi Salehi; Maleki, Majid; Haghjoo, Majid; Noohi, Feridoun; Haghighi, Zahra Ojaghi; Sadeghpour, Anita; Davari, Paridokht Nakhostin; Abkenar, Hooman Bakhshandeh

2013-01-01

Background: Noninvasive techniques for the localization of the accessory pathways (APs) might help guide mapping procedures and ablation techniques. We sought to examine the diagnostic accuracy of strain imaging for the localization of the APs in Wolff-Parkinson-White syndrome. Methods: We prospectively studied 25 patients (mean age = 32 ± 17 years, 58.3% men) with evidence of pre-excitation on electrocardiography (ECG). Electromechanical interval was defined as the time difference between the onset of delta wave and the onset of regional myocardial contraction. Time differences between the onset of delta wave (δ) and the onset of regional myocardial contraction (δ-So), peak systolic motion (δ-Sm), regional strain (δ-ε), peak strain (δ-εp), and peak strain rate (δ-SRp) were measured. Results: There was a significant difference between time to onset of delta wave to onset of peak systolic motion (mean ± SD) in the AP location (A) and normal segments (B) versus that in the normal volunteers (C) [A: (57.08 ± 23.88 msec) vs. B: (75.20 ± 14.75) vs. C: (72.9 0 ± 11.16); p value (A vs. B) = 0.004 and p value (A vs. C) = 0.18] and [A: (49.17 ± 35.79) vs. B: (67.60 ± 14.51) vs. C: (67.40 ± 6.06 msec); p value (A vs. B) < 0.001 and p value (A vs. C) = 0.12, respectively]. Conclusion: Our study showed that strain imaging parameters [(δ-So) and (δ-Strain)] are superior to the ECG in the localization of the APs (84% vs. 76%). PMID:23967027

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile☆

PubMed Central

Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes; Hilber, Karlheinz; Sandtner, Walter

2013-01-01

The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Nav1.5 sodium and Cav1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (≥ 10 μM) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. PMID:23707769

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.

PubMed

Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K; Lukacs, Peter; Gawali, Vaibhavkumar S; Todt, Hannes; Hilber, Karlheinz; Sandtner, Walter

2013-12-01

The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licensed as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Nav1.5 sodium and Cav1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (≥ 10 μM) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Robert Goddard Young, DC, ND: Searching for a better way

PubMed Central

Brown, Douglas M.

2009-01-01

This biographical study tracks the life of Robert Goddard Young; a member of the Canadian Memorial Chiropractic College’s (CMCC) Class of 1950. The paper begins with an overview of Robert Young’s origins, his childhood and early training, moves to his tour of duty in World War II, followed by his education at CMCC, before converging on the core of this matter; Robert Young’s professional career, which spanned over half a century. Now in his twilight years, the paper ends with a discussion on the substance of Dr. Young’s largely-forgotten contributions. PMID:19714235

Test plan for evaluating the operational performance of the prototype nested, fixed-depth fluidic sampler

DOE Office of Scientific and Technical Information (OSTI.GOV)

REICH, F.R.

The PHMC will provide Low Activity Wastes (LAW) tank wastes for final treatment by a privatization contractor from two double-shell feed tanks, 241-AP-102 and 241-AP-104. Concerns about the inability of the baseline ''grab'' sampling to provide large volume samples within time constraints has led to the development of a nested, fixed-depth sampling system. This sampling system will provide large volume, representative samples without the environmental, radiation exposure, and sample volume impacts of the current base-line ''grab'' sampling method. A plan has been developed for the cold testing of this nested, fixed-depth sampling system with simulant materials. The sampling system willmore » fill the 500-ml bottles and provide inner packaging to interface with the Hanford Sites cask shipping systems (PAS-1 and/or ''safe-send''). The sampling system will provide a waste stream that will be used for on-line, real-time measurements with an at-tank analysis system. The cold tests evaluate the performance and ability to provide samples that are representative of the tanks' content within a 95 percent confidence interval, to sample while mixing pumps are operating, to provide large sample volumes (1-15 liters) within a short time interval, to sample supernatant wastes with over 25 wt% solids content, to recover from precipitation- and settling-based plugging, and the potential to operate over the 20-year expected time span of the privatization contract.« less

Analysis of Changes of Cardiological Parameters at Middle Latitude Region in Relation to Geomagnetic Disturbances and Cosmic Ray Variations

NASA Astrophysics Data System (ADS)

Papailiou, M.; Dimitrova, S.; Babayev, E. S.; Mavromichalaki, H.

2010-01-01

Collaborating scientific groups from Athens (Greece), Baku (Azerbaijan) and Sofia (Bulgaria) have conducted a research work on the possible effects of geomagnetic field disturbances (GMF) and cosmic ray intensity (CRI) variations on human homeostasis, particularly, the cardio-health state. Electrocardiograms (ECGs) of seven functionally healthy persons were digitally registered at the joint Laboratory of Heliobiology located in the Medical Centre INAM, Baku, on working days and Saturdays. Heart rate values, estimated from ECGs, were analysed in relation to daily values of CRI, as measured by the Neutron Monitor of the University of Athens and daily variations of Dst and Ap geomagnetic indices and some significant results had been revealed in previous studies. Researches were continued by study of additional cardiologic parameters estimated from the same ECG data. In this study digital data of RR interval (the time elapsing between two consecutive R waves in the ECG), namely RRminimum, RRmaximum and RRaverage were analyzed taking into consideration different levels of GMF disturbances (estimated through variations of Dst and Ap indices) and cosmic ray activity (through CRI variations). The data refer to the time period 15 July 2006-31 March 2008. Variations of RR intervals show connection to GMF disturbances and CRI variations. The revealed effects are more pronounced for high levels of geomagnetic activity (when geomagnetic storms occur) and large CRI decreases as well as on the days before and after these variations.

75 FR 69444 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-12

... South LaSalle Street, Chicago, Illinois 60690-1414: 1. Robert John Dentel, Victor, Iowa, and Mary P. Howell, Ames, Iowa, individually; and the Robert John Dentel Family (Robert J. Dentel, Patricia A. Dentel... Bank, Corydon, Iowa; First State Bank of Colfax, Colfax, Iowa; Maxwell State Bank, Maxwell, Iowa...

Behavior States and a Half-Full Glass: A Response to Mudford, Hogg, and Roberts.

ERIC Educational Resources Information Center

Arthur, Michael

2000-01-01

In this response to critiques (Mudford, Hogg and Roberts 1997, 1999) of the use of behavior states in research involving individuals with mental retardation, it is argued that the work on behavioral state analysis by Robert D. Guess has contributed to the field at the practical, empirical, and theoretical levels. (Contains references.) (CR)

Robert Curl, Jr. and the Discovery of Fullerenes

Science.gov Websites

produced thousands of variations of the buckyball, including carbon sheets one atom thick and microscopic equilibrium in the carbon vapor that allowed the group to identify a unique, 60-atom configuration of carbon Interview with Robert F. Curl, Jr., nobelprize.org (video) Interview with Robert Curl (video) Buckyballs

Tracing the Building of Robert's Connections in Mathematical Problem Solving: A Sixteen-Year Study

ERIC Educational Resources Information Center

Ahluwalia, Anoop

2011-01-01

This research analyzes how external representations created by a student, Robert, helped him in building mathematical understanding over a sixteen-year period. Robert (also known as Bobby), was an original participant of the Rutgers longitudinal study where students were encouraged to work on problem-solving tasks with minimum intervention (Maher,…

A Model for Modern Nonlinear Noncontiguous Operations: The War in Burma, 1943 to 1945

DTIC Science & Technology

2003-05-01

Approved by: _________________________________________ Monograph Director Robert M. Epstein, Ph.D...Professor and Director Robert H. Berlin, Ph.D. Academic Affairs, School of Advanced Military Studies _________________________________________ Director...I would like to thank Dr Robert Epstein for his guidance during the production of this monograph. My thanks also go to my Wife, Aly, for her patience

3. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic Stone Architecture of Winterset, Iowa, Prior to and During the Civil War Period.' Ames, IA: Iowa State University, 1960.) Robert R. Harvey, delineator 1960 FLOOR PLAN, ORIGINAL HOUSE PLUS SMOKEHOUSE ADDITION ('FIGURE 3-C') - Caleb Clark House, 814 South Eighth Street, Winterset, Madison County, IA

2. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic Stone Architecture of Winterset, Iowa, Prior to and During the Civil War Period.' Ames, IA: Iowa State University, 1960.) Robert R. Harvey, delineator 1960 FLOOR PLAN, ORIGINAL HOUSE PLUS WELLHOUSE ADDITION ('FIGURE 3-B') - Caleb Clark House, 814 South Eighth Street, Winterset, Madison County, IA

76 FR 20033 - Robert Charles Ley, D.O. ; Dismissal of Proceeding

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-8] Robert Charles Ley, D.O... Charles Ley, D.O. (Respondent), of Kihei, Hawaii. Order to Show Cause at 1. The Order, which also sought... Suspension of Registration issued to Robert Charles Ley, D.O, be, and it hereby is, dismissed. Dated: April 1...

75 FR 57846 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1... installation, with replacement as necessary for Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1...

Structural Stability of a Joined-Wing Sensorcraft

DTIC Science & Technology

2007-06-01

Robert A. Canfield (Chairman) Date //SIGNED// Dr. Donald Kunz (Member) Date //SIGNED// Maj. Eric...to my thesis advisor, Dr. Robert Canfield, for his guidance and instruction throughout this thesis. His patience and availability were immensely...concept and provide detailed information with regards to the divergence of the linear and nonlinear analysis results of the SensorCraft. Roberts

Engineer Support to the Brigade Combat Team

DTIC Science & Technology

2010-05-20

Director, Robert F. Baumann, Ph.D. Graduate Degree Programs Disclaimer: Opinions, conclusions, and recommendations expressed or implied...companies, now totaling over seven thousand 12 Robert R. Ploger, MG, USA, Vietnam Studies: U.S...mission was complete they would be reallocated to other assets who needed them. The commander of the 18th Engineer Brigade, Major General Robert P

76 FR 51047 - North Dakota; Amendment No. 10 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... authority of the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... arrangements are warranted regarding Federal funds provided under the Robert T. Stafford Disaster Relief and... Assistance costs eligible for such adjustments under the law. The Robert T. Stafford Disaster Relief and...

76 FR 77728 - Process for a Designated Contract Market or Swap Execution Facility To Make a Swap Available To...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

..., 2011 at 9; Letter from Robert Pickel and Kenneth Bentsen, International Swaps and Derivatives..., dated Apr. 5, 2011 at 19; Letter from Robert Pickel and Kenneth Bentsen, International Swaps and... LLP, on behalf of certain dealers, dated Apr. 5, 2011 at 19; Letter from Robert Pickel and Kenneth...

In search of consolidation of short-term memory in nonhuman animals.

PubMed

Calder, Amanda; White, K Geoffrey

2014-03-01

Wixted (Annual Review of Psychology, 55, 235 – 269, 2004) has argued that forgetting is due to consolidation failure. Previous research with humans and nonhuman animals has reported evidence for consolidation in intermediate or long-term memory (LTM). The present study examines whether consolidation occurs in short-term memory in pigeons. Delayed matching-to-sample accuracy was reduced when retroactive interference (an extraneous task in Experiment 1 or houselight illumination in Experiment 2) was interpolated in the retention interval. Accuracy was not greater, however, when interference occurred at the end of the retention interval, as compared with when it occurred at the beginning. That is, there was no evidence for consolidation in short-term memory for pigeons. We did find, however, the beginning–end effect originally reported by Roberts and Grant (Journal of Experimental Psychology: Animal Behavior Processes, 4, 219–236, 1978) and the recovery from forgetting reported by White and Brown (Journal of the Experimental Analysis of Behavior, 96, 177–189, 2011). The results are discussed in relation to temporal distinctiveness theory as an alternative to consolidation.

Big Bang Cosmic Titanic: Cause for Concern?

NASA Astrophysics Data System (ADS)

Gentry, Robert

2013-04-01

This abstract alerts physicists to a situation that, unless soon addressed, may yet affect PRL integrity. I refer to Stanley Brown's and DAE Robert Caldwell's rejection of PRL submission LJ12135, A Cosmic Titanic: Big Bang Cosmology Unravels Upon Discovery of Serious Flaws in Its Foundational Expansion Redshift Assumption, by their claim that BB is an established theory while ignoring our paper's Titanic, namely, that BB's foundational spacetime expansion redshifts assumption has now been proven to be irrefutably false because it is contradicted by our seminal discovery that GPS operation unequivocally proves that GR effects do not produce in-flight photon wavelength changes demanded by this central assumption. This discovery causes the big bang to collapse as quickly as did Ptolemaic cosmology when Copernicus discovered its foundational assumption was heliocentric, not geocentric. Additional evidence that something is amiss in PRL's treatment of LJ12135 comes from both Brown and EiC Gene Spouse agreeing to meet at my exhibit during last year's Atlanta APS to discuss this cover-up issue. Sprouse kept his commitment; Brown didn't. Question: If Brown could have refuted my claim of a cover-up, why didn't he come to present it before Gene Sprouse? I am appealing LJ12135's rejection.

Serving the Needs of Gifted Learners around the Globe: An Interview with Julia Link Roberts

ERIC Educational Resources Information Center

Henshon, Suzanna E.

2018-01-01

Julia Link Roberts is the Mahurin Professor of Gifted Studies at Western Kentucky University (WKU) and the executive director of The Center for Gifted Studies and The Gatton Academy of Mathematics and Science in Kentucky. Dr. Roberts is the president of the World Council for Gifted and Talented Children; current past-president of The Association…

78 FR 22284 - Notice of Intent To Repatriate a Cultural Item: U.S. Department of the Interior, Bureau of Indian...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... Affairs, Washington, DC, and the Robert S. Peabody Museum of Archaeology, Phillips Academy, Andover, MA..., Washington, DC, and in the physical custody of the Robert S. Peabody Museum of Archaeology, Phillips Academy... Archaeology, Phillips Academy, Andover, MA Officials of the Bureau of Indian Affairs and the Robert S. Peabody...

The Marine Corps Martial Arts Program: Sustaining the Transformation

DTIC Science & Technology

2002-04-01

Approved: _______________ Date: _______________ Mentor: Colonel Robert P. Wagner, USMC Approved: _______________ Date: _______________ REPORT... Robert Debs Heinl Jr., USMC (Ret.), Soldiers of the Sea (Annapolis, MD: United States Naval Institute, 1962), 603. 7 constituency of the force, as well...changes over decades, the Marine Corps has shown the ability to adapt its training to meet those conditions. As Colonel Robert Wagner noted, over time

Development of Amphibious Doctrine

DTIC Science & Technology

2010-06-11

Graduate Degree Programs Robert F. Baumann, Ph.D. The opinions and conclusions expressed herein are those of the student author and do not...battalion composed of six companies of Marines, its commander, Lieutenant Colonel Robert W. Huntington, finally received the mission of securing an...42,000 men. The participants included the Commanding Officer, Marine Corps Schools, Colonel Robert Dunlap, as well as the students and instructors

Military Governance and War Termination

DTIC Science & Technology

2011-05-19

Military Studies ___________________________________ Director, Robert F. Baumann, Ph.D. Graduate Degree Programs Disclaimer: Opinions...77 J. Boone Barthlomees, “Theory of Victory,” Parameters XXVII, no. 2 (Summer 2008), 27. 78 Robert Mandel, “Reassessing Victory in Warfare." Armed...political goals, but not, for whatever reasons, reaching total political success.”80 A critical point presented by Dr. Robert Mandel is that victory is

Robert Klopstock and Franz Kafka--the friends from Tatranské Matliare (the High Tatras).

PubMed

Mydlík, M; Derzsiová, K

2007-01-01

The paper summarises the accessible literature on the life and work of well-known American lung surgeon, Professor Dr. Med. Robert Klopstock, who was in the years 1920-1924 a friend Franz Kafka. Professor Klopstock was of Hungarian origin and he got acquainted with Franz Kafka at the end of the year 1920 in Tatranské Matliare (The High Tatras). They were both patients treated for lung tuberculosis. They became close friends and their mutual correspondence shows their real friendship. Robert Klopstock was present at Franz Kafka's death-bed on June 3, 1924 in Kierling, near Klosterneuburg, not far from Vienna. Robert Klopstock studied at Medical Faculties of the Universities in Budapest, Prague, Kiel and Berlin. After his graduation in 1933 in Berlin, he worked as a lung surgeon at various surgical clinics and departments in Budapest and Berlin. In 1936 Robert Klopstock together with his wife visited the High Tatras and Tatranské Matliare. In 1937 Robert Klopstock with his wife Gizela, a writer and a translator, who translated the first chapters of Franz Kafka's novel "Trial" into Hungarian language, went to United States of America. During his stay in U.S.A. Dr. Med. Robert Klopstock was very active as a lung surgeon and a scientist. He published 64 specialized scientific papers, mostly in American medical journals. He became Professor of Lung Surgery at Downstate Medical Centre in New York-Brooklyn. He died on June 15, 1972 in New York.

Dose evaluation for paediatric chest x-ray examinations in Brazil and Sudan: low doses and reliable examinations can be achieved in developing countries

NASA Astrophysics Data System (ADS)

Mohamadain, K. E. M.; da Rosa, L. A. R.; Azevedo, A. C. P.; Guebel, M. R. N.; Boechat, M. C. B.; Habani, F.

2004-03-01

Radiation protection in paediatric radiology deserves special attention since it is assumed that children are more sensitive to radiation than adults. The aim of this work is to estimate the entrance skin dose (ESD), the body organ dose (BOD) and the effective dose (E) for chest x-ray exposure of paediatric patients in five large units, three in Sudan and two in Brazil, and to compare the results obtained in both countries with each other and with other values obtained by some European countries. Two examination projections have been investigated, namely, postero-anterior (PA) and antero-posterior (AP). The age intervals considered were: 0-1 year, 1-5 years, 5-10 years and 10-15 years. The results have been obtained with the use of a software called DoseCal. Results of mean ESD for the age interval 1-5 years and AP projection are: 66 µGy (Instituto de Pediatria e Puericultura Martagão Gesteira—IPPMG Hospital), 41, 86 and 68 µGy (Instituto Fernandes Figueira—IFF Hospital), 161 µGy (Omdurman Hospital), 395 µGy (Khartoum Hospital) and 23 µGy (Ahmed Gasim Hospital). In the case of the IFF Hospital, the results refer, respectively, to rooms 1, 2 and for the six mobile equipments. The reference dose values given by the European Guidelines were exceeded in the Khartoum Hospital whilst in all the other hospitals results obtained were below CEC reference values and comparable with the results found in Sweden, Germany, Spain and Italy. The mean E for the same age interval was 11 µSv in the IPPMG, 6, 15 and 11 µSv in the IFF, respectively for rooms 1, 2 and the 6 mobiles, 25 µSv in the Omdurman Hospital, 45 µSv in the Khartoum Hospital and 3 µSv in the Ahmed Gasim Hospital. These are some examples of the large discrepancies that have been detected in this survey.

A Conversation with Robert F. Christy Part I

NASA Astrophysics Data System (ADS)

Lippincott, Sara

2006-09-01

Robert F. Christy, Institute Professor of Theoretical Physics Emeritus at Caltech, recalls his childhood in British Columbia; his undergraduate years at the University of British Columbia; his graduate work with J. Robert Oppenheimer at Berkeley; and his work on the Manhattan Project, first with Enrico Fermi at the Metallurgical Laboratory of the University of Chicago and then as a member of the Theoretical Division at Los Alamos.

Studying Materials Using Acoustic Waves

DTIC Science & Technology

1988-03-01

Biological Materials." J. Acoust. Soc. Am. 7£, 636 (1981). Robert E. Apfel "Acoustic Cavitation : A Possible Consequence of Biomedical Uses of Ultrasound ...Soc. Am. 19_, 148 (1986). Robert E. Apfel "Possibility of Micro- Cavitation from Diagnostic Ultrasound ." IEEE Trans. on Ultrasonics...Madanshetty and R.A. Roy "Thresholds for Acoustic Cavitation Produced in Water by Pulsed Ultrasound ." Ultrasonics (UK) - in Press. Robert E. Apfel

Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents.

PubMed

Gibson, John K; Yue, Yimei; Bronson, Jared; Palmer, Cassie; Numann, Randy

2014-01-01

It has been proposed that proarrhythmia assessment for safety pharmacology testing includes the use of human pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) to detect drug-induced changes in cardiac electrophysiology. This study measured the actions of diverse agents on action potentials (AP) and ion currents recorded from hiPSC-CM. During AP experiments, the hiPSC-CM were paced at 1Hz during a baseline period, and when increasing concentrations of test compound were administered at 4-minute intervals. AP parameters, including duration (APD60 and APD90), resting membrane potential, rate of rise, and amplitude, were measured throughout the entire experiment. Voltage clamp experiments with E-4031 and nifedipine were similarly conducted. E-4031 produced a dose-dependent prolongation of cardiac action potential and blocked the hERG/IKr current with an IC50 of 17nM. At 3nM, dofetilide significantly increased APD90. Astemizole significantly increased APD60 and APD90 at 30nM. Terfenadine significantly increased APD90 at concentrations greater than 10nM. Fexofenadine, a metabolite of terfenadine, did not produce any electrophysiologic changes in cardiac action potentials. Flecainide produced a dose-dependent prolongation of the cardiac action potential at 1 and 3μM. Acute exposure to nifedipine significantly decreased APD60 and APD90 and produced a dose-dependent block of calcium current with an IC50 of 0.039μM. Verapamil first shortened APD60 and APD90 in a dose-dependent manner, until a compensating increase in APD90, presumably via hERG blockade, was observed at 1 and 3μM. Following a chronic exposure (20-24h) to clinically relevant levels of pentamidine, a significant increase in action potential duration was accompanied by early afterdepolarizations (EADs). These experiments show the ability of AP measured from hiPSC-CM to record the interactions of various ion channels via AP recording and avoid the limitations of using several single ion channel assays in a noncardiac tissue. Copyright © 2014 Elsevier Inc. All rights reserved.

Duration of detection of methamphetamine in hair after abstinence.

PubMed

Suwannachom, Natiprada; Thananchai, Thiwaphorn; Junkuy, Anongphan; O'Brien, Timothy E; Sribanditmongkol, Pongruk

2015-09-01

Researchers in the field of hair analysis have known for at least two decades that test results for many chemical compounds remain positive for a considerable period of time after subjects have reported cessation of use. These findings were generally based on small sample populations or individual case studies. Within the last decade, hair analyses of larger populations have investigated the phenomenon of residual positives in abstinent individuals in order to determine the period of time required for various compounds to present negative hair test results at internationally accepted cutoff levels. Such data has primarily been used to establish guidelines for retesting former abusers of illicit drugs in order to evaluate claims of abstinence. To date, research has focused on cocaine and opiates. The present study is the first to examine the duration of detection of methamphetamine (MA) and its metabolite amphetamine (AP) in the hair of chronic MA users who recently ceased their consumption of the drug. The study population (n=63) consisted of inpatients at a hospital drug rehabilitation program in Chiang Mai, Thailand. Drug taking behavior was collected by personal interview at the time of enrollment. Subjects provided hair samples at approximately monthly intervals for MA and AP analysis by gas chromatography-mass spectrometry at 0.2ng/mg cutoff levels. The correlation of baseline MA and AP concentrations in hair at the beginning of abstinence with corresponding duration of detection indicated great individual variability for the rate of clearance of MA and AP from hair. In regard to duration of detection, the majority of chronic MA users remained MA positive for up to about 90 days of reported abstinence, but by 120 days, the detection rate had fallen to about 16%. All subjects tested negative for MA after 153 days of abstinence. For AP, the limit of the duration of detection was reached at 106 days. With the adoption of a margin of safety to compensate for outlier individual variability, the present study affirmed that hair analysis of chronic MA abusers should test negative for MA after 6 months of claimed abstinence. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease

PubMed Central

Gupta, Neera; Lustig, Robert H; Chao, Cewin; Vittinghoff, Eric; Andrews, Howard; Leu, Cheng-Shiun

2018-01-01

AIM To determine the distribution of anthropometric parameter (AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn’s disease (CD). METHODS CD patients [< chronological age (CA) 21 years] were enrolled in a cross-sectional study. Descriptive statistics were generated for participants’ demographic characteristics and key variables of interest. Paired t-tests were used to compare AP-z-scores calculated based on CA (CA z-scores) and bone age (BA) (BA z-scores) for interpretation of AP’s. Linear regression was utilized to examine associations between medications and serum biomarkers with AP-z-scores calculated based on CA (n = 82) and BA (n = 49). We reported regression coefficients as well as their corresponding p-values and 95% confidence intervals. RESULTS Mean CA at the time of the study visit was 15.3 ± 3.5 (SD; range = 4.8-20.7) years. Mean triceps skinfold (P = 0.039), subscapular skinfold (P = 0.002) and mid-arm circumference (MAC) (P = 0.001) BA z-scores were higher than corresponding CA z-scores. Medications were positively associated with subscapular skinfold [adalimumab (P = 0.018) and methotrexate (P = 0.027)] and BMI CA z-scores [adalimumab (P = 0.029)]. Azathioprine/6-mercaptopurine were negatively associated with MAC (P = 0.045), subscapular skinfold (P = 0.014), weight (P = 0.002) and BMI (P = 0.013) CA z-scores. ESR, CRP, and WBC count were negatively associated, while albumin and IGF-1 BA z-scores were positively associated, with specific AP z-scores (P < 0.05). Mean height CA z-scores were higher in females, not males, treated with infliximab (P = 0.038). Hemoglobin (P = 0.018) was positively associated, while platelets (P = 0.005), ESR (P = 0.003) and CRP (P = 0.039) were negatively associated with height CA z-scores in males, not females. CONCLUSION Our results suggest poor efficacy of thiopurines and a possible sex difference in statural growth response to infliximab in pediatric CD. Prospective longitudinal studies are required. PMID:29760546

Army Amateur Radio System: 1925-1941

DTIC Science & Technology

2010-05-21

1948 Captain Robert L. Gabardy selected the use of the acronym MARS, the Roman god of war, as a fitting name for the post-World War II rebirth of the...3 Robert L. Gabardy , telephonic interview by author, January 26, 2010. In approaching its mission as an auxiliary, MARS can examine...accessed January 25, 2010). Interviews Gabardy , Robert L., interview by author, January 26, 2010. Hart, George, interview by author, January 27

Games for Health, 2011

DTIC Science & Technology

2011-06-01

The Games for Health Project, an effort organized by Digitalmill, Inc. with funding from the Robert Wood Johnson Foundation held its 7th Annual Games...features, media and design patterns associated with videogames. Some of this work is already being done by academia and grantees of Robert Wood ...for game-based interventions really exists (or doesn’t) that can be beneficial to future funding efforts by organizations such as Robert Wood Johnson

Looking Forward: Texas and Its Elderly. Highlights of the Robert Lee Sutherland Seminar (4th, Austin, Texas, May 12, 1984).

ERIC Educational Resources Information Center

Coleman, Marion Tolbert, Ed.; And Others

This document presents the program agenda and highlights from the one-day Robert Lee Sutherland Seminar held to examine the current status and the future of the elderly population of Texas. Included is the speech, "The Longevity Revolution" by Robert N. Butler, in which is discussed the gain in life expectancy, the feminization of aging,…

High Frontier, The Journal for Space & Missile Professionals. Volume 4, Number 4

DTIC Science & Technology

2008-08-01

46 Next Issue: Space Protection High Frontier Introduction General C . Robert Kehler Commander, Air Force Space Command “ The ... the Air Force and General C . Robert “Bob” Kehler (BS, Education, Pennsylvania State University; MS, Public Administra- tion, University of Oklahoma...depth interview with Dr. F. Robert Naka, former deputy director of the NRO (1969- 1972 ) and former chief scientist of the Air Force (1975-1978

The Effect of Advanced Education on the Retention and Promotion of Army Officers

DTIC Science & Technology

2007-03-01

2 Ronal G.Ehrenberg, Robert S.Smith, Modern Labor Economics , Theory and Public Policy, (New York: Pearson Education, Inc, 2006...Ehrenberg and Robert S. Smith, Modern Labor Economics , 9th ed. (New York: Pearson Education, Inc, 2006). 30 G S Becker, Human Capital: A Theoretical...their jobs. As a 32 Ronald G. Ehrenberg and Robert S. Smith, Modern Labor Economics , 9th ed. (New

75 FR 32093 - Revision of Restricted Area R-2504; Camp Roberts, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

...-0557; Airspace Docket No. 10-AWP-6] RIN 2120-AA66 Revision of Restricted Area R-2504; Camp Roberts, CA... Restricted Area R-2504, Camp Roberts, CA, by subdividing the area of R-2504 to create R-2504A and R-2504B. Together, R-2504A and R-2504B will occupy the same lateral and vertical dimensions of the existing R-2504...

Tales from the hundred year history of the American Physical Society

NASA Astrophysics Data System (ADS)

Lustig, H.

1999-05-01

The tale to be told on this occasion - a tale only slightly out of school - is that of the punctuated evolution of the APS in pursuing its hundred years old mission, "the advancement and diffusion of the knowledge of physics". For long periods this goal was pursued, singlemindedly and impressively, through scientfic meetings and the Society's journals. However, within a year of its founding, the APS,in concert with other scientific societies, had already "lobbied" successfully for the establishment of the Bureau of Standards. But then all was quiet on the public front until after World War II. Since that time there have been three waves of forays into the public arena. The first, which spanned the "McCarthy period", was in defense of the freedom of scientists to practice their profession across national boundaries; of the right to announce the results of their research even if they trod on powerful toes (the Astin case); and of individual physicists, such as E.U. Condon and J.Robert Oppenheimer,who had been unfairly accused and badly treated. The second wave occurred in the late sixties and early seventies when, initially much pushed by activist members, the Society's leadership came to grips with broad social issues, such as segregation in the South, the Equal Rights Amendment, and, eventually, arms control and nuclear weapons. The third immersion in public affairs, which is still very much in progress, can be characterized as worrying and speaking out on what physics can do for the country (provide authoritative studies on nuclear energy, renewables, directed energy weapons, etc.) and what the country can do for physics (provide more money). Although lobbying for better funding is still a relatively minor occupation of the Society, it raises the question how physics -an elitist pursuit -can be truthfully and effectively "sold" in a democratic and egalitarian society.

Circadian rhythm of mechanically mediated differentiation of osteoblasts

NASA Technical Reports Server (NTRS)

Roberts, W. E.; Mozsary, P. G.; Klingler, E.

1984-01-01

The differential of osteoblasts in response to orthodontic pressure in the periodontal ligament of the maxillary-first-molar periodontal ligaments of 12-h-light/dark-entrained 7-wk-old male Simonsen outbred rats is measured by (H-3)-Thymidine nuclear-volume morphometry (Roberts et al., 1983) at hourly intervals throughout the circadian cycle. The results are presented in graphs and discussed. Preosteoblast large nuclei (D-cells) are found to synthesize DNA mainly in light and to divide in the following dark period, while small-nucleus osteoprogenitors (A-cells) synthesize in darkness and divide in light. These findings are seen as consistent with a model in which the sequence of proliferation and differentiation requires at least 60 h (five 12-h periods) and the shift from A to D cells lasts about 19 h.

Atrazine degradation in a small stream in Iowa

USGS Publications Warehouse

Kolpin, D.W.; Kalkhoff, S.J.

1993-01-01

A study was conducted during 1990 through an 11.2-km reach of Roberts Creek in northeastern Iowa to determine the fate of atrazine in a surface water environment Water samples were collected at ~1-month intervals from April through November during stable low to medium flow conditions and analyzed for atrazine and two of its initial biotic degradation products, desethylatrazine and deisopropylatrazine. Samples were collected on the basis of a Lagrangian model of streamflow in order to sample the same parcel of water as it moved downstream. Atrazine concentrations substantially decreased (roughly 25-60%) between water entering and exiting the study reach during four of the seven sampling periods. During these same four sampling periods, the concentrations of the two biotic atrazine degradation products were constant or decreasing downstream, suggesting an abiotic degradation process.

Dr. Robert Goddard

NASA Image and Video Library

2010-01-04

Dr. Robert Goddard and colleagues at Roswell, New Mexico. Successful test of May 19, 1937. Dr. Robert Goddard is holding the cap and pilot parachute, parts of the successful operation. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

The Evolution of Marine Artillery: A History of Versatility and Relevance

DTIC Science & Technology

2012-03-28

Colonel Robert W. Huntington who commanded it, was formed. This included one artillery company manning four 3-inch rapid fire guns.7 The Marine...Major Robert H. Dunlap. That same battalion, which would soon be the foundation for the 10th Marine Regiment, distinguished itself in combat at La...force capable of counter-guerilla operations. Of note, Colonel Robert H. Dunlap commanded the regiment. 19 Officers during this period were versatile

Sustaining Equipment and the Rapid Acquisition Process: The Forgotten Phase

DTIC Science & Technology

2012-02-24

Operation of the Defense Acquisition System,” December 8, 2008. 7 Rasch , Robert. A, Jr. Lessons Learned from Rapid Acquisition: Better, Faster, Cheaper...Life Cycle Management Responsibilities,” Defense AR Journal, 17.2 (April 2010): 183. 37 Robert A. Rasch , Lessons Learned from Rapid Acquisition: Better...Accountability Office (GAO) Report, Subject: Rapid Acquisition of Mine Resistant Protected Vehicles, July 15, 2008, 4. 39 Ibid. 40 Ibid. 41 Robert A. Rasch

The Operational Air National Guard: Relationship Changes and Policy Implications

DTIC Science & Technology

2015-02-13

Operational ANG” after U.S. withdrawal from Iraq and Afghanistan. Secretary of Defense Robert Gates’ 19 January 2007 memo, “Utilization of the Total...the RCs provide strategic depth and are available to transition to operational roles as needed. 25 Secretary of Defense, Robert M. Gates, 19...An Illustrated History of America’s Citizen-Soldiers. Dulles, VA: Potomac Books Inc., 2007. Gates, Robert M., U.S. Secretary of Defense. To

An Extensive X-ray Computed Tomography Evaluation of a Fully Penetrated Encapsulated SiC MMC Ballistic Panel

DTIC Science & Technology

2009-04-01

An Extensive X-ray Computed Tomography Evaluation of a Fully Penetrated Encapsulated SiC MMC Ballistic Panel by William H. Green and Robert H...Panel William H. Green and Robert H. Carter Weapons and Materials Research Directorate, ARL...PROGRAM ELEMENT NUMBER 2182040 6. AUTHOR(S) William H. Green and Robert H. Carter 5d. PROJECT NUMBER AH80 5e. TASK NUMBER 5f. WORK UNIT

Building Component Maintenance and Repair Data Base: Heating, Ventilating, and Air Conditioning (HVAC) Systems

DTIC Science & Technology

1991-05-01

Building Component Maintenance and Repair Data Base: Heating, Ventilating, and Air Conditioning (HVAC) Systems by Edgar S. Neely Robert D. Neathammer...Repair Data Base: Heating, Ventilating, and Air Conditioning (HVAC) Systems RDTE dated 1980EIMB 1984 - 1989 6. AUTHOR(S) Edgar S. Neely, Robert D...Laboratory (USACERL). The Principal Investigators were Dr. Edgar Neely and Mr. Robert Neathammer (USACERL-FS). The primary contractor for much of the

Defense Planning for the 1990s and the Changing International Environment

DTIC Science & Technology

1984-01-01

Atlantic Alliance: Looking Ahead ................. 87 Dr. Robert L. Pfaltzgraff, Jr. The Future of the American NATO Commitment ......... 109 Dr...avenues of approach to the ques- tion. Dr. George H. Quester approached NATO’s future from the peespective of American political philosophy. Dr. Robert L...offices whose assign- ment would be to conduct long-range planning on a continuing basis. 85 The Atlantic Alliance: Looking Ahead Dr. Robert L. Pfaltzgraff

Development of a Robust Static Punch Experiment for Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material

DTIC Science & Technology

2014-09-01

Cross-Ply Material by David Gray, Robert Kaste , and Paul Moy ARL-TR-7090 September 2014...Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material David Gray, Robert Kaste , and Paul...ELEMENT NUMBER 6. AUTHOR(S) David Gray, Robert Kaste , and Paul Moy 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7

Civil-Military Relations: From Vietnam to Operation Iraqi Freedom

DTIC Science & Technology

2009-05-01

Robert F. Baumann, Ph.D. Graduate Degree Programs ii Abstract CIVIL-MILITARY RELATIONS: FROM VIETNAM TO OPERATION IRAQI FREEDOM by MAJOR Brandon...Oxford: Oxford University Press, 2007), 285-324. 43 Ibid. 44 Robert M. Gates, 2008 National Defense Strategy (Washington D.C.: Department Of Defense...Dereliction of Duty: Lyndon Johnson, Robert McNamara, the Joint Chiefs of Staff, and the Lies That Led to Vietnam (New York: HarperCollins, 1997), 13. 60

Organizational Culture Challenges to Interagency and Intelligence Community Communication and Interaction

DTIC Science & Technology

2006-05-31

York: McGraw-Hill, 2003), p 121. 103 Gortner, Mahler, and Nicholson, p 74. 104 Robert B. Denhardt, Theories of Public Organization. (Belmont, CA...Uninformed: Government Secrecy in the 1980’s. New York: Pilgrim Press, 1984. Denhardt, Robert B. Theories of Public Organization. Belmont, CA: Brooks/Cole...Fixing Intelligence: For a More Secure America. New Haven, CT: Yale University Press, 2003. Odom, William E. and Robert Dujarric. America’s Inadvertent

Improvements to the Understanding of the Fire Performance of Wood over the Past 30 Years-A Tribute to Robert Hawthorne White

Treesearch

Samuel L. Zelinka; Mark A. Dietenberger; Laura E. Hasburgh; Keith J. Bourne; Charles Boardman

2015-01-01

Dr. Robert Hawthorne White had a 31 year career researching the fire performance of wood and wood composites at the USDA Forest Products Laboratory. Over his career, Dr. White made substantial contributions to codes, standards, and regulations pertaining to the design of wood structures. This review article summarizes Robert’s major accomplishments as a tribute to his...

In re Marriage of Moschetta.

PubMed

1994-06-10

Cynthia Moschetta petitioned to obtain separation from her husband, Robert Moschetta, and to establish her maternity as to Marissa Moschetta, who was conceived pursuant to a traditional surrogacy contract. Elvira Jordan, the surrogate mother, sought to join the dissolution action, and Robert Moschetta requested judgment of dissolution. The Orange County Superior Court awarded joint legal and physical custody to Elvira Jordan and Robert Moschetta. Robert Moschetta appealed, challenging the determination that Jordan is the legal mother of Marissa and contending that Cynthia Moschetta is the legal mother of the child by virtue of the Uniform Parentage Act. The appellate court affirmed Jordan's parental rights, reversed the awarding of joint physical custody, remanded the latter question for reevaluation, and called for legislative guidance on the problems arising from surrogacy arrangements.

John Bowlby and ethology: an annotated interview with Robert Hinde.

PubMed

Bowlby, John

2007-12-01

From the 1950s, John Bowlby, one of the founders of attachment theory, was in personal and scientific contact with leading European scientists in the field of ethology (e.g., Niko Tinbergen, Konrad Lorenz, and especially Robert Hinde). In constructing his new theory on the nature of the bond between children and their caregivers, Bowlby profited highly from their new approach to (animal) behavior. Hinde and Tinbergen in their turn were influenced and inspired by Bowlby's new thinking. On the basis of extensive interviews with bowlby's colleague and lifelong friend Robert Hinde and on the basis of archival materials, both the relationship between John Bowlby and Robert Hinde and the cross-fertilization of ethology and attachment theory are described.

Non-invasive, non-radiological quantification of anteroposterior knee joint ligamentous laxity

PubMed Central

Russell, D. F.; Deakin, A. H.; Fogg, Q. A.; Picard, F.

2013-01-01

Objectives We performed in vitro validation of a non-invasive skin-mounted system that could allow quantification of anteroposterior (AP) laxity in the outpatient setting. Methods A total of 12 cadaveric lower limbs were tested with a commercial image-free navigation system using trackers secured by bone screws. We then tested a non-invasive fabric-strap system. The lower limb was secured at 10° intervals from 0° to 60° of knee flexion and 100 N of force was applied perpendicular to the tibia. Acceptable coefficient of repeatability (CR) and limits of agreement (LOA) of 3 mm were set based on diagnostic criteria for anterior cruciate ligament (ACL) insufficiency. Results Reliability and precision within the individual invasive and non-invasive systems was acceptable throughout the range of flexion tested (intra-class correlation coefficient 0.88, CR 1.6 mm). Agreement between the two systems was acceptable measuring AP laxity between full extension and 40° knee flexion (LOA 2.9 mm). Beyond 40° of flexion, agreement between the systems was unacceptable (LOA > 3 mm). Conclusions These results indicate that from full knee extension to 40° flexion, non-invasive navigation-based quantification of AP tibial translation is as accurate as the standard validated commercial system, particularly in the clinically and functionally important range of 20° to 30° knee flexion. This could be useful in diagnosis and post-operative evaluation of ACL pathology. Cite this article: Bone Joint Res 2013;2:233–7. PMID:24184443

Altered characteristics of balance control in obese older adults.

PubMed

Melzer, Itshak; Oddsson, Lars I E

2016-01-01

Obesity is one of the most significant epidemiological trends of the last decades. Recently it was found that obese individuals show postural instability. Balance control mechanisms in obese older adults were less studied. Therefore we aimed to investigate the effect of obesity on balance control mechanisms in older adults. Parameters from Stabilogram-Diffusion Analysis (SDA) and measures from summary statistics of foot centre-of-pressure (COP) displacements along the anterior-posterior (AP) and mediolateral (ML) directions in eyes open and eyes closed conditions were used to characterize postural control in 22 obese (30-<35kg/m(2)), 26 overweight (25-<30kg/m(2)), and 18 normal weight subjects (18.5-<25kg/m(2)). Obese group subjects demonstrated significantly greater transition displacement, transition time interval, and short-term scaling exponent in the ML-direction compared with the normal weight group (eyes open and closed). In the AP-direction the obese group showed greater transition displacement (eyes open) and short-term scaling exponent (eyes open and closed). Average AP-COP and ML-COP ranges of COP sway were higher in the obese group compared with the normal weight group (eyes open and closed). This work indicates an altered postural control process in obese older adults. A greater sway displacement before closed-loop feedback mechanisms are called into play was seen in the ML direction that may lead to a higher risk of instability and fall events. Copyright © 2015 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Pharmacological modulations of cardiac ultra-rapid and slowly activating delayed rectifier currents: potential antiarrhythmic approaches.

PubMed

Islam, Mohammed A

2010-01-01

Despite the emerging new insights into our understandings of the cellular mechanisms underlying cardiac arrhythmia, medical therapy for this disease remains unsatisfactory. Atrial fibrillation (AF), the most prevalent arrhythmia, is responsible for significant morbidity and mortality. On the other hand, ventricular fibrillation results in sudden cardiac deaths in many instances. Prolongation of cardiac action potential (AP) is a proven principle of antiarrhythmic therapy. Class III antiarrhythmic agents prolong AP and QT interval by blocking rapidly activating delayed rectifier current (I(Kr)). However, I(Kr) blocking drugs carry the risk of life-threatening proarrhythmia. Recently, modulation of atrial-selective ultra-rapid delayed rectifier current (I(Kur)), has emerged as a novel therapeutic approach to treat AF. A number of I(Kur) blockers are being evaluated for the treatment of AF. The inhibition of slowly activating delayed rectifier current (I(Ks)) has also been proposed as an effective and safer antiarrhythmic approach because of its distinguishing characteristics that differ in remarkable ways from other selective class III agents. Selective I(Ks) block may prolong AP duration (APD) at rapid rates without leading to proarrhythmia. This article reviews the pathophysiological roles of I(Kur) and I(Ks) in cardiac repolarization and the implications of newly developed I(Kur) and I(Ks) blocking agents as promising antiarrhythmic approaches. Several recent patents pertinent to antiarrhythmic drug development have been discussed. Further research will be required to evaluate the efficacy and safety of these agents in the clinical setting.

A Legion Apart

DTIC Science & Technology

2012-03-16

NUMBER Colonel Robert Mundell Department of Command, Leadership, & Management 9. SPONSORING...Colonel Robert Mundell Project Adviser This SRP is submitted in partial fulfillment of the requirements of the Master of

Exercise testing in children with Wolff-Parkinson-White syndrome: what is its value?

PubMed

Dalili, M; Vahidshahi, K; Aarabi-Moghaddam, M Y; Rao, J Y; Brugada, P

2014-10-01

This study was conducted to evaluate the accuracy of exercise testing for predicting accessory pathway characteristics in children with Wolff-Parkinson-White (WPW) syndrome. The study enrolled 37 children with WPW syndrome and candidates for invasive electrophysiologic study (EPS). Exercise testing was performed for all the study participants before the invasive study. Data from the invasive EPS were compared with findings from the exercise testing. The sudden disappearance of the delta (Δ) wave was seen in 10 cases (27 %). No significant correlation was found between the Δ wave disappearance and the antegrade effective refractory period of the accessory pathway (AERP-AP) or the shortest pre-excited RR interval (SPERRI). The sensitivity, specificity, and positive and negative predictive values of Δ wave disappearance, based on AERP-AP as gold standard, were respectively 29.4, 80, 71.4, and 40 %. The corresponding values with SPERRI as the gold standard were respectively 23.8, 71.4, 71.4 and 23.8 %. Exercise testing has a medium to low rate of accuracy in detecting low-risk WPW syndrome patients in the pediatric age group.

Robert Tirawat | NREL

Science.gov Websites

-performance, high-reliability systems that use concentrated sunlight to generate power. Recently, Robert has been involved developing a high-efficiency solar selective absorber and anti-corrosion coatings

Numerical Methods in Atmospheric and Oceanic Modelling: The Andre J. Robert Memorial Volume

NASA Astrophysics Data System (ADS)

Rosmond, Tom

Most people, even including some in the scientific community, do not realize how much the weather forecasts they use to guide the activities of their daily lives depend on very complex mathematics and numerical methods that are the basis of modern numerical weather prediction (NWP). André Robert (1929-1993), to whom Numerical Methods in Atmospheric and Oceanic Modelling is dedicated, had a career that contributed greatly to the growth of NWP and the role that the atmospheric computer models of NWP play in our society. There are probably no NWP models running anywhere in the world today that do not use numerical methods introduced by Robert, and those of us who work with and use these models everyday are indebted to him.The first two chapters of the volume are chronicles of Robert's life and career. The first is a 1987 interview by Harold Ritchie, one of Robert's many proteges and colleagues at the Canadian Atmospheric Environment Service. The interview traces Robert's life from his birth in New York to French Canadian parents, to his emigration to Quebec at an early age, his education and early employment, and his rise in stature as one of the preeminent research meteorologists of our time. An amusing anecdote he relates is his impression of weather forecasts while he was considering his first job as a meteorologist in the early 1950s. A newspaper of the time placed the weather forecast and daily horoscope side by side, and Robert regarded each to have a similar scientific basis. Thankfully he soon realized there was a difference between the two, and his subsequent career certainly confirmed the distinction.

The Vietnam Cauldron: Defense Intelligence in the War for Southeast Asia

DTIC Science & Technology

2012-01-01

For the Patriots. Major Robert P. Perry, USA Celeste M. Brown Vivienne A. Clark Dorothy M. Curtiss Joan K. Pray Doris J. Watkins Colonel Charles R. Ray...USA Chief Warrant Officer Robert W. Prescott, USA Chief Warrant Officer Kenneth D. Welch, USA Petty Officer First Class Michael R. Wagner, USN...Marshall Karl W. Teepe Patricia E. Mickley Robert J. Hymel Rosa M. Chapa Sandra N. Foster Charles E. Sabin i Defense Intelligence Historical Perspectives

China: Suspected Acquisition of U.S. Nuclear Weapon Secrets

DTIC Science & Technology

2006-02-01

Benjamin Kang, “China Nuclear Halt May Stem From Deal,” Reuters, July 30, 1996; Robert Karniol, “Nuclear Blast Heralds A Chinese Moratorium,” Jane’s Defense...Leak,” New York Times, April 8, 1999. 12 FBI, “Statement by FBI Director Robert S. Mueller,” April 9, 2003; Katrina Leung Affidavit; James J. Smith...the appropriate congressional committees and the White House on April 21, 1999. Robert Walpole, the National Intelligence Officer for Strategic and

Reducing Long-Term Costs While Preserving a Robust Strategic Airlift Fleet: Options for the Current Fleet and Next-Generation Aircraft

DTIC Science & Technology

2013-01-01

Ghashghai, Jeff Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert S. Leonard, Rosalind Lewis, Elvira N. Loredo, Daniel M. Norton, David T...Joan Cornuet, Mel Eisman, Chris Fitzmartin, Jean R. Gebman, Elham Ghashghai, Jeff Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert...Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert S. Leonard, Rosa- lind Lewis, Elvira N. Loredo, Daniel M. Norton, David T. Orletsky

Building Maintenance and Repair Data for Life-Cycle Cost Analyses: Electrical Systems.

DTIC Science & Technology

1991-05-01

Repair Data for Life-Cycle Cost Analyses: Electrical Systems by Edgar S. Neely Robert D. Neathammer James R. Stirn Robert P. Winkler This research...systems have been developed to assist planners in preparing DD Form 1391 documentation, designers in life-cycle cost component selection, and maintainers...Maintenance and Repair Data for Life-Cycle Cost Analyses: RDTE dated 1980 Electrical Systems REIMB 1984 - 1989 6. AUTH4OR(S) Edgar S. Neely, Robert D

Getting America Ready for Japanese Science and Technology Held at Washington, DC on 7-8 February 1985.

DTIC Science & Technology

1985-05-15

TRANSLATION: A LONG-TERM SOLUTION MACHINE TRANSLATIONS: DEVELOPMENTS AND PROSPECTS 96 Robert A. Russell, Assistant Professor, Department of Asian and...chairman of the board of WCC, Chicago. He is a member of the Japanese National Automatic Translation Telephone Development Committee. 1 ROBERT A. RUSSELL...redussol- Westerism through indexing enineiring student to trai- speaking M Ono"e langisage. 067 pubfiahang-some in services. said Robert W. Gib- law

Structural Optimization of a Distributed Actuation System in a Flexible In-Plane Morphing Wing

DTIC Science & Technology

2007-06-01

Captain, USAF Approved: /signed/ 11 Jun 2007 Dr. Robert Canfield (Chairman) date /signed/ 11 Jun 2007 Dr. Brian Sanders (Member) date /signed/ 11 Jun...can be seen here at the Camp Roberts Flight Test Range [11]. separation, which ultimately increased the overall lift. During wind tunnel tests, the...Matlabr . The outermost loop was written by Mark Spillman and Dr. Robert Canfield and was based on Schittkowski’s Sequential Quadratic Programming (SQP

The Federal Role in Funding State and Local Infrastructure: Two Reports on Public Works Financing

DTIC Science & Technology

1993-08-01

comments are welcome on any of these reports. For further information on the Federal Infrastructure Strategy Program, please contact Robert A. Pietrowsky ...Eugene Z. Stakhiv, Chief, Policy and Special Studies Division; and the FIS Study Team which includes Mr. Robert A. Pietrowsky , Program Manager, Mr...and visiting fellow of the Navigation Division of IWR, and Mr. Robert Pietrowsky for their helpful comments on the introduction. Mention must also be

Effects of megavoltage computed tomographic scan methodology on setup verification and adaptive dose calculation in helical TomoTherapy.

PubMed

Zhu, Jian; Bai, Tong; Gu, Jiabing; Sun, Ziwen; Wei, Yumei; Li, Baosheng; Yin, Yong

2018-04-27

To evaluate the effect of pretreatment megavoltage computed tomographic (MVCT) scan methodology on setup verification and adaptive dose calculation in helical TomoTherapy. Both anthropomorphic heterogeneous chest and pelvic phantoms were planned with virtual targets by TomoTherapy Physicist Station and were scanned with TomoTherapy megavoltage image-guided radiotherapy (IGRT) system consisted of six groups of options: three different acquisition pitches (APs) of 'fine', 'normal' and 'coarse' were implemented by multiplying 2 different corresponding reconstruction intervals (RIs). In order to mimic patient setup variations, each phantom was shifted 5 mm away manually in three orthogonal directions respectively. The effect of MVCT scan options was analyzed in image quality (CT number and noise), adaptive dose calculation deviations and positional correction variations. MVCT scanning time with pitch of 'fine' was approximately twice of 'normal' and 3 times more than 'coarse' setting, all which will not be affected by different RIs. MVCT with different APs delivered almost identical CT numbers and image noise inside 7 selected regions with various densities. DVH curves from adaptive dose calculation with serial MVCT images acquired by varied pitches overlapped together, where as there are no significant difference in all p values of intercept & slope of emulational spinal cord (p = 0.761 & 0.277), heart (p = 0.984 & 0.978), lungs (p = 0.992 & 0.980), soft tissue (p = 0.319 & 0.951) and bony structures (p = 0.960 & 0.929) between the most elaborated and the roughest serials of MVCT. Furthermore, gamma index analysis shown that, compared to the dose distribution calculated on MVCT of 'fine', only 0.2% or 1.1% of the points analyzed on MVCT of 'normal' or 'coarse' do not meet the defined gamma criterion. On chest phantom, all registration errors larger than 1 mm appeared at superior-inferior axis, which cannot be avoided with the smallest AP and RI. On pelvic phantom, craniocaudal errors are much smaller than chest, however, AP of 'coarse' presents larger registration errors which can be reduced from 2.90 mm to 0.22 mm by registration technique of 'full image'. AP of 'coarse' with RI of 6 mm is recommended in adaptive radiotherapy (ART) planning to provide craniocaudal longer and faster MVCT scan, while registration technique of 'full image' should be used to avoid large residual error. Considering the trade-off between IGRT and ART, AP of 'normal' with RI of 2 mm was highly recommended in daily practice.

Persistent and susceptible bacteria with individual deaths.

PubMed

Zucca, Fabio

2014-02-21

The aim of this paper is to study two models for a bacterial population subject to antibiotic treatments. It is known that some bacteria are not sensitive to antibiotics. These bacteria, called persisters, are in a state called persistence and each bacterium can switch from this state to a non-persistent (or susceptible) state and back (with rates b and a respectively). Our models extend those introduced in Garet et al. (2012) by adding a random natural life cycle for each bacterium and by allowing bacteria in the susceptible state to escape the action of the antibiotic with a fixed probability 1-p (while every bacterium in a persistent state survives with probability 1). This last mechanism of survival to the antibiotics differs from the persistent state one (where reproduction is forbidden) since in this case the bacterium can replicate. We study two different models. In the first model we "inject" the antibiotics in the system at fixed, deterministic times while in the second one the time intervals are random. We show that, in order to kill eventually the whole bacterial population, these time intervals cannot be "too large". The maximum admissible length is increasing with respect to p; we see that even when p is close to 1, this interval length can be significantly smaller than in the case p=1. While in the case p=1 switching back and forth to the persistent state is the only chance of surviving for bacteria, when p<1 and the death rate in the persistent state, say dr, is positive then the situation is more complex. In this case our model suggests that if dr and b are positive (and fixed) then for higher values of p there is an interval for the rate a, say (0,ap) where switching to the persistent state is a good strategy while for a>ap the situation is less favorable than a=0. On the other hand, for smaller values of p the best strategy is a=0, that is, not switching. Finally, when dr=0, switching to the susceptible state is always a better strategy, from the bacterial point of view, than staying in the susceptible state all the times. Copyright © 2013 Elsevier Ltd. All rights reserved.

Associate Administrator, Robert Lightfoot address the Marshall Association.

NASA Image and Video Library

2015-07-28

NASA ASSOCIATE ADMINISTRATOR ROBERT LIGHTFOOT SHARED HIS PERSONAL REFLECTIONS ON LEADERSHIP WITH MARSHALL ASSOCIATION MEMBERS AND GUESTS DURING A LUNCHEON JULY 28 AT NASA’S MARSHALL SPACE FLIGHT CENTER.

Development of a Free-Electron Laser Center and Research in Medicine, Biology and Materials Science,

DTIC Science & Technology

1992-05-14

Elastin Production in Tissue Culture", Debra A.Gonzalez MD, David L. Zealear, PhD., J.M. Davidson, PhD., Robert H. Ossoff, MD, DMD , August 1990...Otolaryngoloty-Head and Neck Surgery. K. "CO2 Laser Micromanipulator Parallax Error Resolved, Jay Werkhaven,MD, Jerri Tribble, and Robert H. Ossoff, MD, DMD ...of the Upper Aerodigestive Tract, Robert H. Ossoff, MD, DMD , Al Aly, MD, Nick Houchin, AAS, and Debra Gonzalez, MD, Vanderbilt University, Nashville

America’s last battles: Organizing brigades to win the peace lessons from East Timor, Afghanistan, and Iraq

DTIC Science & Technology

2004-06-17

Graduate Degree Programs Robert F. Baumann, Ph.D. The opinions and conclusions expressed herein are those of the student author and do not...primary research method this study will follow is the case study method as outlined in Robert K. Yin’s, Case Study Research: Design and Methods. By using...The method is also policy relevant as it generates lessons relevant to different situations. In Robert K. Yin’s words, “An important step . . . is the

Robert Halliday Gunning and the Victoria Jubilee prizes.

PubMed

Baillie, T W

2003-05-01

More than a century after the death of Robert Halliday Gunning, a large number of lectureships and prizes bearing his name continue to be awarded by scientific bodies and learned institutions in Scotland. Most of these awards were endowed in HM Queen Victoria s Jubilee year (1887-88) and bear the additional qualification 'Victoria Jubilee'. An account of the life of Robert Gunning and his various endowments is complemented by an analysis of the factors which determined the nature of his benefactions.

Environmental Analysis of Lake Pontchartrain, Louisiana, Its Surrounding Wetlands, and Selected Land Uses. Volume 1.

DTIC Science & Technology

1980-02-01

M. Darnell,* Richard W. Heard,* Robert C. Cashner,* and Olivia House* e Graduate Modeling Robert E. Hinchee and Linda A. Deegan Students Grassbeds...James H. Stone, B. T. Gael, Linda A. Deegan , Robert E. Hinchee, John W. Day, Jr., Leonard M. Bahr, Jr., and R. E. Turner R. C. Cashner is affiliated with...Sciences Linda A. Deegan , Graduate Assistant David D. Dow, Research Associate III Nancy A. Drummond, Graduate Assistant Marion Fannaly, Research Associate

Two autographs: Cecile Dewitt and Robert Hawking (for Steven Hawking)

NASA Astrophysics Data System (ADS)

Gaina, Alex

2007-12-01

Two autographs given to author by professor Cecile Dewitt and Robert Hawking (the son of Steven Hawking for his father) in 1987 during the Quantum Gravity Seminar in Moscow are presented. The first was given during a visit to Physical Institute of the Academy of sciences of the USSR, where a seminar held in the Theoretical department. the second was given during a lunch with Steven Hawking, Andrei Linde and Robert Hawking at the 2-nd floor of the Conference floor.

Group for High Resolution Sea Surface Temperature (GHRSST) Analysis Fields Inter-Comparisons. Part 1: A GHRSST Multi-Product Ensemble (GMPE)

DTIC Science & Technology

2012-05-02

Le Borgne, P., Poulter, D., Vazquez-Cuervo, J., Armstrong, E., Beggs, H., Llewellyn - Jones , D., Minnett, P., Merchant, C., Evans, R., 2009. The GODAE...Donlon i, Chelle Gentemann j, Robert Grumbine k, Shiro Ishizaki l, Eileen Maturi b, Richard W. Reynoldsm, Jonah Roberts- Jones a a Met Office, Exeter...high-resolution sea surface temperature pilot project. Oceanography 22, 34–45. Donlon, C.J., Martin, M., Stark, J.D., Roberts- Jones , J., Fiedler, E

Investigation of the Numerical Methods of Finite Differences and Weighted Residuals for Solution of the Heat Equation.

DTIC Science & Technology

1982-03-01

OF FINITE DIFFERENCES AND WEIGHTED RESIDUALS FOR SOLUTION OF THE HEAT EQUATION a THESIS J’. AFIT/GNE/PH/81-7 *-.1 Robert Naegeli .. ....... J --aC t...Institute of Technology Air University in Partial Fulfillment of the a Requirements for the Degree of Master of Science by Robert E. Naegeli , M.S. Capt USAF...a time which proved to be one of great personal adjustment and turmoil. Robert E. Naegeli ii Contents Page Preface

Competent, Confident and Agile? A Study of the U.S. Army Leadership Requirements Model and its Application for U.S. Army Company Commanders

DTIC Science & Technology

2011-06-10

Thesis Committee Chair John M. Persyn, Ph.D. , Member LTC Eric K. Dunahee, M.S. , Member Robert D. Bloomquist, M.A...Accepted this 10th day of June 2011 by: , Director, Graduate Degree Programs Robert F. Baumann, Ph.D. The opinions and conclusions expressed...have been possible without the support of my committee, Dr. John M. Persyn, LTC Eric K. Dunahee and Mr. Robert D. Bloomquist. Thank you for your

Accommodation and convergence during sustained computer work.

PubMed

Collier, Juanita D; Rosenfield, Mark

2011-07-01

With computer usage becoming almost universal in contemporary society, the reported prevalence of computer vision syndrome (CVS) is extremely high. However, the precise physiological mechanisms underlying CVS remain unclear. Although abnormal accommodation and vergence responses have been cited as being responsible for the symptoms produced, there is little objective evidence to support this claim. Accordingly, this study measured both of these oculomotor parameters during a sustained period of computer use. Subjects (N = 20) were required to read text aloud from a laptop computer at a viewing distance of 50 cm for a sustained 30-minute period through their habitual refractive correction. At 2-minute intervals, the accommodative response (AR) to the computer screen was measured objectively using a Grand Seiko WAM 5500 optometer (Grand Seiko, Hiroshima, Japan). Additionally, the vergence response was assessed by measuring the associated phoria (AP), i.e., prism to eliminate fixation disparity, using a customized fixation disparity target that appeared on the computer screen. Subjects were asked to rate the degree of difficulty of the reading task on a scale from 1 to 10. Mean accommodation and AP values during the task were 1.07 diopters and 0.74∆ base-in (BI), respectively. The mean discomfort score was 4.9. No significant changes in accommodation or vergence were observed during the course of the 30-minute test period. There was no significant difference in the AR as a function of subjective difficulty. However, the mean AP for the subjects who reported the least and greatest discomfort during the task was 1.55∆ BI and 0, respectively (P = 0.02). CVS, after 30 minutes was worse in subjects exhibiting zero fixation disparity when compared with those subjects having a BI AP but does not appear to be related to differences in accommodation. A slightly reduced vergence response increases subject comfort during the task. Copyright © 2011 American Optometric Association. Published by Elsevier Inc. All rights reserved.

Early Assessment of Pancreatic Infections and Overall Prognosis in Severe Acute Pancreatitis by Procalcitonin (PCT)

PubMed Central

Rau, Bettina M.; Kemppainen, Esko A.; Gumbs, Andrew A.; Büchler, Markus W.; Wegscheider, Karl; Bassi, Claudio; Puolakkainen, Pauli A.; Beger, Hans G.

2007-01-01

Background: Pancreatic infections and sepsis are major complications in severe acute pancreatitis (AP) with significant impact on management and outcome. We investigated the value of Procalcitonin (PCT) for identifying patients at risk to develop pancreatic infections in severe AP. Methods: A total of 104 patients with predicted severe AP were enrolled in five European academic surgical centers within 96 hours of symptom onset. PCT was measured prospectively by a semi-automated immunoassay in each center, C-reactive protein (CRP) was routinely assessed. Both parameters were monitored over a maximum of 21 consecutive days and in weekly intervals thereafter. Results: In contrast to CRP, PCT concentrations were significantly elevated in patients with pancreatic infections and associated multiorgan dysfunction syndrome (MODS) who all required surgery (n = 10) and in nonsurvivors (n = 8) early after onset of symptoms. PCT levels revealed only a moderate increase in patients with pancreatic infections in the absence of MODS (n = 7), all of whom were managed nonoperatively without mortality. A PCT value of ≥3.5 ng/mL on 2 consecutive days was superior to CRP ≥430 mg/L for the assessment of infected necrosis with MODS or nonsurvival as determined by ROC analysis with a sensitivity and specificity of 93% and 88% for PCT and 40% and 100% for CRP, respectively (P < 0.01). The single or combined prediction of the two major complications was already possible on the third and fourth day after onset of symptoms with a sensitivity and specificity of 79% and 93% for PCT ≥3.8 ng/mL compared with 36% and 97% for CRP ≥430 mg/L, respectively (P = 0.002). Conclusion: Monitoring of PCT allows early and reliable assessment of clinically relevant pancreatic infections and overall prognosis in AP. This single test parameter significantly contributes to an improved stratification of patients at risk to develop major complications. PMID:17457167

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koenig, Xaver; Kovar, Michael; Rubi, Lena

The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologouslymore » expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (≥ 10 μM) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: • We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. • We assess the cardiac ion channel profile of ibogaine. • Ibogaine inhibits hERG potassium, sodium and calcium channels. • Ibogaine’s effects on ion channels are a potential source of cardiac arrhythmias. • 18-Methoxycoronaridine has a lower affinity for cardiac ion channels than ibogaine.« less

Aspirin or heparin or both in the treatment of recurrent spontaneous abortion in women with antiphospholipid antibody syndrome: a meta-analysis of randomized controlled trials.

PubMed

Lu, Chang; Liu, Yong; Jiang, Hai-Li

2018-01-10

This study was designed to evaluate the efficacy of aspirin or heparin or both in the treatment for recurrent spontaneous abortion (RSA) in women with antiphospholipid antibody syndrome (APS). Systematic searches for randomized clinical trials (RCTs) evaluating on live birth and preterm delivery, preeclampsia, intrauterine growth restriction, gestational diabetes, bleeding of RSA with APS patients receiving aspirin, and heparin therapy were carried out, from PubMed, EMBASE, ScienceDirect, and CNKI. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5.3 for analysis. Relative risk (RR) and its 95% confidence interval were calculated. Nineteen publications with randomized controlled trials were selected for this study, which included a total of 1251 pregnant patients with diagnosis of RSA with APS. With respect to live birth, it was remarkably improved in aspirin plus heparin or heparin alone group [RR =1.23, 95% CI (1.12-1.36), p < .0001; RR = 1.18, 95% CI (1.03-1.35), p = .02]; aspirin alone group, however, there was no statistically significant difference compare to placebo [RR = 0.97, 95% CI (0.80-1.16), p = .71]. Meanwhile, aspirin plus heparin therapy did not significantly reduce the risk of recurrent placenta-mediated pregnancy complications including preterm birth, intrauterine growth retardation (IUGR), gestational diabetes, and minor bleeding. A beneficial therapeutic effect of heparin alone therapy was found on preventing preterm birth and low-dose aspirin plus heparin therapy was significant reduce the risk of preeclampsia. An improvement of pregnancy outcomes in women with RSA and APS can be achieved by treatment strategies combining low-dose aspirin plus heparin or heparin alone. Aspirin alone, by contrast, seemed inferior to other treatments in achieving more live birth.

7. Historic American Buildings Survey, Robert E. Cooper, Photographer January, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey, Robert E. Cooper, Photographer January, 1961 DEMOLITION, SHOWING STRUCTURAL ELEMENTS. - American Life Insurance Company Building, 330-336 Walnut Street, Philadelphia, Philadelphia County, PA

Official portrait of astronaut Robert C. Springer

NASA Technical Reports Server (NTRS)

1988-01-01

Official portrait of astronaut Robert C. Springer, United Stated Marine Corps (USMC) Colonel, member of Astronaut Class 9 (1980), and mission specialist. Springer wears launch and entry suit (LES) while holding helmet.

Association of American Indian Physicians

MedlinePlus

... Scholars Program This program of the Robert Wood Johnson Foundation is a leadership development opportunity for practitioners ... for Clinical Scholars program supported by Robert Wood Johnson Foundation will open in January 2018. https://t. ...

Astronaut Robert L. Crippen prepares for underwater training session

NASA Technical Reports Server (NTRS)

1983-01-01

Astronaut Robert L. Crippen, STS-7 crew commander, adjusts his extravehicular mobility unit's (EMU) gloves prior to donning his helmet for a training session in the weightless environment test facility (WETF).

78 FR 11090 - Flightcrew Member Duty and Rest Requirements; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-15

... this action, contact Dale E. Roberts, AFS-200, Flight Standards Service, Air Transportation Division...- 5749; email dale[email protected] . For legal questions concerning this action, contact Robert Frenzel...

6. Historic American Buildings Survey Robert W. Kerrigan, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey Robert W. Kerrigan, Photographer August 24, 1936 INTERIOR DETAIL WEST WALL OF SOCIAL HALL - Trocadero Inn, Sigmund Stern Grove, San Francisco, San Francisco County, CA

6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James Dix Schuyler, 1903. Source: Schuyler report. - Waddell Dam, On Agua Fria River, 35 miles northwest of Phoenix, Phoenix, Maricopa County, AZ

Peculiar Traits of Coarse AP (Briefing Charts)

DTIC Science & Technology

2014-12-01

coarse AP Bircumshaw, Newman Active centers are sources of AP decomposition gases AP low temperature decomposition (LTD) Most unstable AP particles ...delay before coarse AP ejection *Coarse AP particle flame retardancy 19 Air Force Research Laboratory Distribution A: Approved for public release...distribution unlimited. PA clearance #. Combustion bomb trials 2 AP phase change may enable coarse particle breakage Fractured coarse AP ejection agrees

Observation of Two-Dimensional Localized Jones-Roberts Solitons in Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Meyer, Nadine; Proud, Harry; Perea-Ortiz, Marisa; O'Neale, Charlotte; Baumert, Mathis; Holynski, Michael; Kronjäger, Jochen; Barontini, Giovanni; Bongs, Kai

2017-10-01

Jones-Roberts solitons are the only known class of stable dark solitonic solutions of the nonlinear Schrödinger equation in two and three dimensions. They feature a distinctive elongated elliptical shape that allows them to travel without change of form. By imprinting a triangular phase pattern, we experimentally generate two-dimensional Jones-Roberts solitons in a three-dimensional atomic Bose-Einstein condensate. We monitor their dynamics, observing that this kind of soliton is indeed not affected by dynamic (snaking) or thermodynamic instabilities, that instead make other classes of dark solitons unstable in dimensions higher than one. Our results confirm the prediction that Jones-Roberts solitons are stable solutions of the nonlinear Schrödinger equation and promote them for applications beyond matter wave physics, like energy and information transport in noisy and inhomogeneous environments.

Cognitive remediation therapy and cognitive behavioral therapy with an older adult with anorexia nervosa: A brief case report.

PubMed

Darcy, Alison M; Fitzpatrick, Kara K; Lock, James

2016-06-01

Cognitive remediation therapy represents a new approach to the treatment of anorexia nervosa (AN) emerging from research, suggesting that adults with chronic AN have specific neurocognitive inefficiencies. Specifically, adults with AN demonstrate an overly detailed cognitive processing bias (Roberts, Tchanturia, & Treasure, 2013) and difficulties shifting set quickly and efficiently (Roberts, Tchanturia, Stahl, Southgate, & Treasure, 2007). These characteristics manifest as rigid, rule-bound, and detail-focused cognitions, beliefs, and behaviors. Versions of these problems appear to persist after weight restoration (Tchanturia et al., 2004) and are observable in patient's healthy sisters (Roberts et al., 2013). Thus, central coherence difficulties and set-shifting problems have been proposed as endophenotypes and maintaining factors of AN (Roberts et al., 2013). (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Erratum: The Hubble Space Telescope Key Project on the Extragalactic Distance Scale. XXVIII. Combining the Constraints on the Hubble Constant

NASA Astrophysics Data System (ADS)

Mould, Jeremy R.; Huchra, John P.; Freedman, Wendy L.; Kennicutt, Robert C., Jr.; Ferrarese, Laura; Ford, Holland C.; Gibson, Brad K.; Graham, John A.; Hughes, Shaun M. G.; Illingworth, Garth D.; Kelson, Daniel D.; Macri, Lucas M.; Madore, Barry F.; Sakai, Shoko; Sebo, Kim M.; Silbermann, Nancy A.; Stetson, Peter B.

2000-12-01

In the article ``The Hubble Space Telescope Key Project on the Extragalactic Distance Scale. XXVIII. Combining the Constraints on the Hubble Constant'' (ApJ, 529, 786 [2000]), by Jeremy R. Mould, John P. Huchra, Wendy L. Freedman, Robert C. Kennicutt, Jr., Laura Ferrarese, Holland C. Ford, Brad K. Gibson, John A. Graham, Shaun M. G. Hughes, Garth D. Illingworth, Daniel D. Kelson, Lucas M. Macri, Barry F. Madore, Shoko Sakai, Kim M. Sebo, Nancy A. Silbermann, and Peter B. Stetson, some sign errors need to be corrected. 1. In equation (A2) the minus signs should be plus signs. The correct version is Vcosmic=VH+Vc,LG+Vin,Virgo+Vin,GA+Vin,Shap+... 2. In Table A1 the declination of the Great Attractor (GA) is -44°, and that of the Shapley supercluster is -31°, i.e., south declination, not north, as implied in the table. The first error is the authors' and the second occurred in the publication process. In both cases the computer code was correct, and the errors are in the published representation. None of the results presented in the paper are therefore affected in any way. The authors thank Dr. Jim Condon for pointing out the error in equation (A2)

Integration of new geologic mapping and satellite-derived quartz mapping yields insights into the structure of the Roberts Mountains allochthon applicable to assessments for concealed Carlin-type gold deposits

USGS Publications Warehouse

Holm-Denoma, Christopher S.; Hofstra, Albert H.; Rockwell, Barnaby W.; Noble, Paula J.

2012-01-01

Geologic mapping and remote sensing across north-central Nevada enable recognition of a thick sheet of Middle and Upper Ordovician Valmy Formation quartzite that structurally overlies folded and faulted Ordovician through Devonian stratigraphic units of the Roberts Mountains allochthon. In the northern Independence Mountains and nearby Double Mountain area, the Valmy Formation is in fault contact with Ordovician through Silurian, predominantly clastic, sedimentary rocks of the Roberts Mountains allochthon that were deformed prior to, or during, emplacement of the Valmy thrust sheet. Similar structural relations are recognized discontinuously for 200 kilometers along the strike of the Roberts Mountains allochthon in mapping guided by regional remote-sensing-based (ASTER) quartz maps. Overall thicknesses of deformed Roberts Mountains allochthon units between the base of the Valmy and the top of underlying carbonate rocks that host large Carlin-type gold deposits varies on the order of hundreds of meters but is not known to exceed 700 meters. The base of the Valmy thrust sheet is a complimentary datum in natural resource exploration and mineral resource assessment for concealed Carlin-type gold deposits.

San Joaquin kit fox Vulpes macrotis mutica program, Camp Roberts, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Camp Roberts is a California Army National Guard Training Site located in central California. The San Joaquin kit fox, an endangered subspecies of kit fox, has been known to occur at Camp Roberts since 1960. The population of foxes began to increase in the early 1970's when use of rodenticides decreased. In 1987 the California Army National Guard contracted EG G Energy Measurements to conduct a 3-year study to assess the effects of Camp Roberts activities on the kit fox population. The major objective of the Camp Roberts Environmental Studies Program is to prepare a comprehensive Biological Assessment of themore » effects of all NGB-authorized activities (includes military training, anticipated construction projects, repair and maintenance activities, and all NGB-authorized non-military activities such as hunting and fishing programs, grazing leases, etc.) on San Joaquin kit fox. The program also provides NGB with the scientific expertise necessary to insure compliance with the Endangered Species Act. The specific objective of this report is to summarize progress and results of the Environmental Studies Program made during Fiscal Years 1989 and 1990 (FY89/90). 32 refs., 9 figs., 14 tabs.« less

Meet EPA Scientist Robert Devlin, Ph.D.

EPA Pesticide Factsheets

EPA scientist Dr. Robert Devlin's main research interest is understanding the health effects of air pollution. His research characterizes the effects that inhaled substances, such as air pollutants, have on human pulmonary and cardiovascular health

24. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 13, 1936 VIEW FROM RIGHT SIDE - SOUTH - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

43. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 GENERAL VIEW TOWARD FRONT ENTRANCE - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

31. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

31. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 DETAIL OF FONT (Original) - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

22. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo Taken: May 13, 1936 VIEW FROM EAST - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

44. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 COLUMN AND PULPIT DETAIL - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

45. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 COLUMN AND WINDOW DETAIL - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

21. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo Taken: May 14, 1936 VIEW FROM NORTH - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

ZERO-G - Crippen, Robert L.

NASA Image and Video Library

1979-04-03

Zero-gravity experiments in KC-135 conducted by John Young, Robert L. Crippen, Joseph Kerwin, and Margaret Seddon. 1. Kerwin, Joseph - Zero-G 2. Seddon, Margaret - Zero-G 3. Young, John - Zero-G 4. Aircraft - KC-135

U.S. Environmental Protection Agency's Robert S. Kerr Environmental Research Center, Ada, Oklahoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farrar-Nagy, S.; Voss, P.; Van Geet, O.

2006-10-01

U.S. EPA's Robert S. Kerr Environmental Research Center, Ada, Oklahoma, has reduced its annual energy consumption by 45% by upgrading its building mechanical system and incorporating renewable energy.

A concurrent resolution calling on the President and the allies of the United States to raise in all appropriate bilateral and multilateral fora the case of Robert Levinson at every opportunity, urging Iran to fulfill their promises of assistance to the family of Robert Levinson, and calling on Iran to share the results of its investigation into the disappearance of Robert Levinson with the Federal Bureau of Investigation.

THOMAS, 111th Congress

Rep. Wexler, Robert [D-FL-19

2009-02-03

Senate - 11/18/2009 Placed on Senate Legislative Calendar under General Orders. Calendar No. 214. (All Actions) Tracker: This bill has the status Agreed to in HouseHere are the steps for Status of Legislation:

Cultural Resources Survey and Testing Along Ditch 19 Dunklin and Stoddard Counties, Missouri

DTIC Science & Technology

1987-07-15

AD-A265 021 I/ A CULTURAL RESOURCES SURVEY AND TESTING (I ALONG DITCH 19 DUNKLIN AND STODDARD COUNTIES , MISSOURI by Kathryn A. King and * viy Robert...and Stoddard Counties , MO C 53-7103-7-545 6. AUTHOR(S) Kathryn A. King Robert H. Lafferty III 7. PERFORM•!NG ORGANIZATION NAME•S) AND ADDRESS’ES) 8...CULTURAL RESOURCES SURVEY AND TESTING ALONG DITCH 19 DUNKLIN AND STODDARD COUNTIES , MISSOURI by Kathryn A. King and Robert H. Lafferty III 1EL E C T

Promoting medical innovation while developing sound social and business policy: a conversation with Thomas G. Roberts. Interview by Barbara J. Culliton.

PubMed

Roberts, Thomas G

2008-01-01

The development of "targeted biologics" as cancer therapy has made the field ripe for investment from the private sector and is changing the face of cancer medicine, while also raising important policy concerns about price, profit, and continued innovation. In this interview Barbara Culliton talks with Thomas Roberts, who sees this world from a unique perspective. Roberts, an oncologist, has practiced at the Massachusetts General Hospital and is currently thinking about innovation as a hedge fund manager.

A Comparison of the Operational Art of George Gordon Meade and Robert Edward Lee during the Period June 1863, to March 1864.

DTIC Science & Technology

1988-03-29

PERIOD COVERED A Comparison of the Operational Art of George G. Meade and Robert E. Lee During the Period Jun 1 8 6 3 Indiv study project to March...publication until it has been cleared by the appropriate military Service er gover"uent aency. A Comparison Of The Operational Art Of George Gordon...and/or Dis Speclal;! Sp ABSTRACT AUTHOR: THOMAS A. GREEN, LTC, AV. TITLE: A Comparison of the Operational Art of George Gordon Meade and Robert Edward

Buzzard Island Dredged Material Beneficial Use Access Road, Upper Mississippi River, River Mile 349, Pool 20. General Design Memorandum and Environmental Assessment

DTIC Science & Technology

1988-06-01

contact the above number for more information. DOW E. PROUTY. PRESIDENT * ROBERT C. MESKIMEN , PRESIDENT-ELECT UO E I. S TH sl’w KENNETH W. MCNICHOLS...the Mississippi River. Cofesburg. Iowa Members of the Iowa Limestone Producers Association ROBERT C. MESKIMEN Marlin Marietta Aggregates very strongly...cc: Missouri DOC (Farabee, Dieffenbach) ITUW L7f DOW E. PROUTY. PRESIDENT 0 ROBERT C. MESKIMEN . PRESIDENT-ELECT I uSre r/m $111 KENNETH W. McNICHOLS

Index of National Aviation Facilities Experimental Center Technical Reports 1972-1977.

DTIC Science & Technology

1981-05-01

EVALUATION OF DIGITAL ALTIMETER SETTING INDICATORS Robert Frack , Ernest E. Sch’atter and Jack Bernstein Final, August 1975 55 P. (RD-75-81) (AD A013 994...runway would change the surface friction of that runway. The method consisted of jetting water at high velocity to hydraulically remove the rubber from...77-49 Erikson, Robert H. 74-17 Feher, Ray E. 76-53; 77-22 Fisher, Donald A. 74-24; 75-48; 76-15 Fisher, John J. 73-41 Frack , Robert 74-46 Gallagher

Youth Drinking in the United States: Relationships With Alcohol Policies and Adult Drinking

PubMed Central

Xuan, Ziming; Blanchette, Jason G.; Nelson, Toben F.; Nguyen, Thien H.; Hadland, Scott E.; Oussayef, Nadia L.; Heeren, Timothy C.

2015-01-01

BACKGROUND: The relationship between the alcohol policy environment (ie, the combined effectiveness and implementation of multiple existing alcohol policies) and youth drinking in the United States has not been assessed. We hypothesized that stronger alcohol policy environments are inversely associated with youth drinking, and this relationship is partly explained by adult drinking. METHODS: Alcohol Policy Scale (APS) scores that characterized the strength of the state-level alcohol policy environments were assessed with repeated cross-sectional Youth Risk Behavior Survey data of representative samples of high school students in grades 9 to 12, from biennial years between 1999 and 2011. RESULTS: In fully adjusted models, a 10 percentage point increase in APS scores (representing stronger policy environments) was associated with an 8% reduction in the odds of youth drinking and a 7% reduction in the odds of youth binge drinking. After we accounted for youth-oriented alcohol policies, the subgroup of population-oriented policies was independently associated with lower odds of youth drinking (adjusted odds ratio 0.94; 95% confidence interval 0.92–0.97) and youth binge drinking (adjusted odds ratio 0.96; 95% confidence interval 0.94–0.99). State-level per capita consumption mediated the relationship between population-oriented alcohol policies and binge drinking among youth. CONCLUSIONS: Stronger alcohol policies, including those that do not target youth specifically, are related to a reduced likelihood of youth alcohol consumption. These findings suggest that efforts to reduce youth drinking should incorporate population-based policies to reduce excessive drinking among adults as part of a comprehensive approach to preventing alcohol-related harms. Future research should examine influence of alcohol policy subgroups and discrete policies. PMID:26034246

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity.

PubMed

Passini, Elisa; Britton, Oliver J; Lu, Hua Rong; Rohrbacher, Jutta; Hermans, An N; Gallacher, David J; Greig, Robert J H; Bueno-Orovio, Alfonso; Rodriguez, Blanca

2017-01-01

Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction. Human-based computer models constitute a fast, cheap and potentially effective alternative to experimental assays, also facilitating translation to human. Key challenges include consideration of inter-cellular variability in drug responses and integration of computational and experimental methods in safety pharmacology. Our aim is to evaluate the ability of in silico drug trials in populations of human action potential (AP) models to predict clinical risk of drug-induced arrhythmias based on ion channel information, and to compare simulation results against experimental assays commonly used for drug testing. A control population of 1,213 human ventricular AP models in agreement with experimental recordings was constructed. In silico drug trials were performed for 62 reference compounds at multiple concentrations, using pore-block drug models (IC 50 /Hill coefficient). Drug-induced changes in AP biomarkers were quantified, together with occurrence of repolarization/depolarization abnormalities. Simulation results were used to predict clinical risk based on reports of Torsade de Pointes arrhythmias, and further evaluated in a subset of compounds through comparison with electrocardiograms from rabbit wedge preparations and Ca 2+ -transient recordings in human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Drug-induced changes in silico vary in magnitude depending on the specific ionic profile of each model in the population, thus allowing to identify cell sub-populations at higher risk of developing abnormal AP phenotypes. Models with low repolarization reserve (increased Ca 2+ /late Na + currents and Na + /Ca 2+ -exchanger, reduced Na + /K + -pump) are highly vulnerable to drug-induced repolarization abnormalities, while those with reduced inward current density (fast/late Na + and Ca 2+ currents) exhibit high susceptibility to depolarization abnormalities. Repolarization abnormalities in silico predict clinical risk for all compounds with 89% accuracy. Drug-induced changes in biomarkers are in overall agreement across different assays: in silico AP duration changes reflect the ones observed in rabbit QT interval and hiPS-CMs Ca 2+ -transient, and simulated upstroke velocity captures variations in rabbit QRS complex. Our results demonstrate that human in silico drug trials constitute a powerful methodology for prediction of clinical pro-arrhythmic cardiotoxicity, ready for integration in the existing drug safety assessment pipelines.

Magnetic Resonance Imaging Assessment of Spinal Cord and Cauda Equina Motion in Supine Patients With Spinal Metastases Planned for Spine Stereotactic Body Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tseng, Chia-Lin; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario; Sussman, Marshall S.

2015-04-01

Purpose: To assess motion of the spinal cord and cauda equina, which are critical neural tissues (CNT), which is important when evaluating the planning organ-at-risk margin required for stereotactic body radiation therapy. Methods and Materials: We analyzed CNT motion in 65 patients with spinal metastases (11 cervical, 39 thoracic, and 24 lumbar spinal segments) in the supine position using dynamic axial and sagittal magnetic resonance imaging (dMRI, 3T Verio, Siemens) over a 137-second interval. Motion was segregated according to physiologic cardiorespiratory oscillatory motion (characterized by the average root mean square deviation) and random bulk shifts associated with gross patient motionmore » (characterized by the range). Displacement was evaluated in the anteroposterior (AP), lateral (LR), and superior-inferior (SI) directions by use of a correlation coefficient template matching algorithm, with quantification of random motion measure error over 3 separate trials. Statistical significance was defined according to P<.05. Results: In the AP, LR, and SI directions, significant oscillatory motion was observed in 39.2%, 35.1%, and 10.8% of spinal segments, respectively, and significant bulk motions in all cases. The median oscillatory CNT motions in the AP, LR, and SI directions were 0.16 mm, 0.17 mm, and 0.44 mm, respectively, and the maximal statistically significant oscillatory motions were 0.39 mm, 0.41 mm, and 0.77 mm, respectively. The median bulk displacements in the AP, LR, and SI directions were 0.51 mm, 0.59 mm, and 0.66 mm, and the maximal statistically significant displacements were 2.21 mm, 2.87 mm, and 3.90 mm, respectively. In the AP, LR, and SI directions, bulk displacements were greater than 1.5 mm in 5.4%, 9.0%, and 14.9% of spinal segments, respectively. No significant differences in axial motion were observed according to cord level or cauda equina. Conclusions: Oscillatory CNT motion was observed to be relatively minor. Our results support the importance of controlling bulk patient motion and the practice of applying a planning organ-at-risk margin.« less

Longitudinal study of bone loss in pre- and perimenopausal women: evidence for bone loss in perimenopausal women.

PubMed

Chapurlat, R D; Garnero, P; Sornay-Rendu, E; Arlot, M E; Claustrat, B; Delmas, P D

2000-01-01

Bone loss before and around the time of menopause is not well characterized by longitudinal studies. We measured bone mineral density at various skeletal sites--total body, femoral neck, trochanter, anteroposterior (AP) and lateral spine, and forearm--with dual-energy X-ray absorptiometry in a large prospective cohort of 272 untreated pre- and perimenopausal women aged 31-59 years, at 1 year intervals for 3 years. Sex steroids and the following markers of bone remodeling were measured: serum osteocalcin (OC), procollagen I carboxyterminal extension peptide, bone alkaline phosphatase (BAP) and urinary crosslinks (CTX and NTX). Seventy-six women were classified as perimenopausal and 196 as premenopausal. Over the 3 years, premenopausal women had no significant bone loss at any site and a small but significant increase in bone mineral density at the trochanter, total hip, AP spine and radius. Perimenopausal women significantly lost bone from cancellous and cortical sites, i.e., the femoral neck, trochanter and lumbar spine. In perimenopausal women with increased follicle stimulating hormone, the rate of bone loss at the femoral neck correlated negatively with OC and BAP. In perimenopausal women, serum estradiol levels decreased during the 3 years of follow-up and bone loss from the trochanter and the AP spine was correlated with serum estradiol after 3 years. In conclusion, among premenopausal women there is no bone loss. In contrast, there is a rapid and diffuse bone loss in perimenopausal women, related to decreased estrogen secretion. Bone markers may be useful to identify these women losing bone.

The role of omega-3 fatty acids in acute pancreatitis: a meta-analysis of randomized controlled trials.

PubMed

Lei, Qiu Cheng; Wang, Xin Ying; Xia, Xian Feng; Zheng, Hua Zhen; Bi, Jing Cheng; Tian, Feng; Li, Ning

2015-03-31

To determine whether treatment with omega-3 fatty acids (ω-3 FA) provides benefits to patients with acute pancreatitis (AP). The Cochrane Library, PubMed, Embase, Web of Science, and Chinese Biomedical Literature Database were searched. Data analysis was performed using Revman 5.2 software. A total of eight randomized controlled trials (RCTs) were included. Overall, ω-3 FA treatment resulted in a significantly reduced risk of mortality (RR 0.35; 95% CI 0.16 to 0.75, p < 0.05), infectious complications (RR 0.54; 95% CI 0.34 to 0.85, p < 0.05) and length of hospital stay (MD -6.50; 95% CI -9.54 to -3.46, p < 0.05), but not length of ICU stay (MD -1.98; 95% CI -6.92 to 2.96, p > 0.05). In subgroup analysis, only patients who received ω-3 FA parenterally had some statistically significant benefits in terms of mortality (risk ratio (RR) 0.37; 95% confidence interval (CI) 0.16 to 0.86, p < 0.05), infectious complications (RR 0.5; 95% CI 0.28 to 0.9, p < 0.05) and length of hospital stay (mean difference (MD) -8.13; 95% CI -10.39 to -5.87, p < 0.001). The administration of ω-3 FA may be beneficial for decreasing mortality, infectious complications, and length of hospital stay in AP, especially when used parenterally. Large and rigorously designed RCTs are required to elucidate the efficacy of parenteral or enteral ω-3 FA treatment in AP.

DefenseLink Special: Travels with Gates, January 2007

Science.gov Websites

that has been achieved there, said Defense Secretary Robert M. Gates. Story Gates to Build on Success , and Defense Secretary Robert M. Gates wants to build on those successes. Story Afghan Army Makes

47. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 DETAIL OF ARCH - RIGHT SIDE ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

48. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 DETAIL OF ARCH - RIGHT SIDE ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

50. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

50. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 15, 1936 DETAIL OF SMALL CHAPEL (Not original) - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

46. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo Taken: May 14, 1936 DETAIL OF ARCH LEFT SIDE - ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

23. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 GENERAL VIEW FROM LEFT SIDE - WEST - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

42. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 GENERAL VIEW OF INTERIOR - TOWARD ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

Modernizing the Military Retirement System

DTIC Science & Technology

2011-05-01

Patrick Gross, David Langstaff, Philip Odeen, Mark Ronald, Robert Stein, and Jack Zoeller. Catherine Whittington served as the Board Staff Analyst...Chair) Patrick Gross David Langstaff Philip Odeen Mark Ronald Robert Stein Jack Zoeller DBB Staff Analyst Catherine Whittington Methodology

33. Historic American Buildings Survey Robert W. Kerrigan, Photographer Dec. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. Historic American Buildings Survey Robert W. Kerrigan, Photographer Dec. 11, 1936 MONUMENT IN OLD CEMETERY (THE OLDEST MARKED GRAVE) - Mission San Francisco de Asis, Mission & Sixteenth Streets, San Francisco, San Francisco County, CA

Total Army Analysis Supporting Maximization of National Resources

DTIC Science & Technology

2013-03-01

Robert M. Mundell Department of Command Leadership and Management 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY...Colonel Robert M. Mundell Department of Command Leadership and Management Project Adviser This manuscript is submitted in partial fulfillment

Acute Pancreatitis and Use of Pancreatitis-Associated Drugs: A 10-Year Population-Based Cohort Study.

PubMed

Bertilsson, Sara; Kalaitzakis, Evangelos

2015-10-01

To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectively identified. Data regarding AP etiology, severity, and recurrence and use of AP-associated drugs were extracted from medical records. Drugs were classified according to an evidence-based classification system. Annual drug sales data were obtained from the Swedish drug administration service. Overall, 1457 cases of incident AP were identified. Acute pancreatitis-associated drug users increased from 32% in 2003 to 51% in 2012, reflecting increasing user rates in the general population. The incidence of AP increased during the study period but was not related to AP-associated drug user rates (P > 0.05). Recurrent AP occurred in 23% but was unrelated to AP-associated drug use (P > 0.05). In logistic regression analysis, after adjustment for comorbidity, AP-associated drug use was not related to AP severity (P > 0.05). Use of AP-associated drugs is increasingly frequent in patients with AP. However, it does not have any major impact on the observed epidemiological changes in occurrence, severity, or recurrence of AP.

Effect of clothing type on validity of air-displacement plethysmography.

PubMed

King, George A; Fulkerson, Bethany; Evans, Michael J; Moreau, Kerrie L; McLaughlin, James E; Thompson, Dixie L

2006-02-01

The purpose of the study was to evaluate the validity of an air-displacement plethysmography system (AP) within the general population, while wearing (1) a racing-type swimsuit (AP(SS)) and (2) participant's personal undergarments (AP(UG)), against hydrodensitometry (HW). Fifty women and 50 men were measured for body volume, density, and fat percentage by HW and compared with AP(SS) and AP(UG). For women, AP(UG) and AP(SS) were similar, although significant differences (p < 0.001) were observed between AP(UG) and HW and between AP(SS) and HW. For men, there was no significant difference between AP(UG) and HW; however, significant differences (P < or = 0.01) were found between AP(UG) and AP(SS) and between AP(SS) and HW. The small discrepancy in measured values between AP and HW are within the measurement error for the instrumentation and these data support the use of AP for determination of body composition in adults across a wide range of body size (body mass index [BMI] 17.7-35.2 kg.m(-2)) and age (18-57 y). Participants' personal undergarments provide a practical alternative to a spandex swimsuit when measuring body composition by AP in women but not in men.

Purification, characterisation and protective effects of polysaccharides from alfalfa on hepatocytes.

PubMed

Wang, Shaopu; Dong, Xiaofang; Ma, Hao; Cui, Yaoming; Tong, Jianming

2014-11-04

The objective of this study was to determine the preliminary characteristics and protective effects of alfalfa polysaccharides (APS) on hepatocytes in vitro. The crude APS was purified by DEAE-cellulose and Sephadex G-100 chromatography, resulting in the four purified fractions: APS-1, APS-2, APS-3 and APS-4. The results indicated that APS-3 had higher carbohydrate and uronic acid contents and that APS-4 had a more complicated monosaccharide composition compared to the other purified fractions. The average molecular weights of APS-1, APS-2, APS-3 and APS-4 were 48,536, 6,221, 66,559 and 13,076 Da, respectively. Furthermore, APS (crude and its purified fractions) restored the activities of antioxidant enzymes and increased the total antioxidant capacity of hepatocytes subjected to H2O2-induced oxidative stress. Furthermore, APS treatment counteracted the increases in lactic dehydrogenase and malonaldehyde in the culture supernatant. These results clearly demonstrate that APS possesses a protective effect against oxidative injury in hepatocytes. Copyright © 2014 Elsevier Ltd. All rights reserved.

US EPA Freedom of Information Act Workgroup Report: Prepared for Robert Perciasepe, Deputy Administrator

EPA Pesticide Factsheets

Deputy Administrator Robert Perciasepe requested a workgroup develop options and recommendations to ensure that the Agency’s administration of FOIA and related processes are effective, efficient and promote open government and transparency policies.

Siegfried Receives 2006 Robert C. Cowen Award

NASA Astrophysics Data System (ADS)

Siegfried, Tom

2006-07-01

Tom Siegfried received the 2006 Robert C. Cowen Award for Sustained Achievement in ScienceJournalism at the Joint Assembly Honors Ceremony, which was held on 25 May 2006 inBaltimore, Md. The award honors lifetime achievement in science journalism.

Developing Strategic Leader Competencies in Today’s Junior Officer Corps

DTIC Science & Technology

2013-03-01

AND ADDRESS(ES) Colonel Robert M. Mundell Department of Command, Leadership, and Management 8. PERFORMING ORGANIZATION REPORT NUMBER 9...O’Donnell United States Army Colonel Robert M. Mundell Department of Command, Leadership, and Management Project Adviser

Overexpression of two PsnAP1 genes from Populus simonii × P. nigra causes early flowering in transgenic tobacco and Arabidopsis.

PubMed

Zheng, Tangchun; Li, Shuang; Zang, Lina; Dai, Lijuan; Yang, Chuanping; Qu, Guan-Zheng

2014-01-01

In Arabidopsis, AP1 is a floral meristem identity gene and plays an important role in floral organ development. In this study, PsnAP1-1 and PsnAP1-2 were isolated from the male reproductive buds of poplar (Populus simonii × P. nigra), which are the orthologs of AP1 in Arabidopsis, by sequence analysis. Northern blot and qRT-PCR analysis showed that PsnAP1-1 and PsnAP1-2 exhibited high expression level in early inflorescence development of poplar. Subcellular localization showed the PsnAP1-1 and PsnAP1-2 proteins are localized in the nucleus. Overexpression of PsnAP1-1 and PsnAP1-2 in tobacco under the control of a CaMV 35S promoter significantly enhanced early flowering. These transgenic plants also showed much earlier stem initiation and higher rates of photosynthesis than did wild-type tobacco. qRT-PCR analysis further indicated that overexpression of PsnAP1-1 and PsnAP1-2 resulted in up-regulation of genes related to flowering, such as NtMADS4, NtMADS5 and NtMADS11. Overexpression of PsnAP1-1 and PsnAP1-2 in Arabidopsis also induced early flowering, but did not complement the ap1-10 floral morphology to any noticeable extent. This study indicates that PsnAP1-1 and PsnAP1-2 play a role in floral transition of poplar.

P alpha-chiral phosphorothioate analogues of bis(5'-adenosyl)tetraphosphate (Ap4A); their enzymatic synthesis and degradation.

PubMed Central

Lazewska, D; Guranowski, A

1990-01-01

Synthesis of Sp and Rp diastereomers of Ap4A alpha S has been characterized in two enzymatic systems, the lysyl-tRNA synthetase from Escherichia coli and the Ap4A alpha, beta-phosphorylase from Saccharomyces cerevisiae. The synthetase was able to use both (Sp)ATP alpha S and (Rp)ATP alpha S as acceptors of adenylate thus yielding corresponding monothioanalogues of Ap4A,(Sp) Ap4A alpha S and (Rp)Ap4A alpha S. No dithiophosphate analogue was formed. Relative synthetase velocities of the formation of Ap4A,(Sp) Ap4A alpha S and (Rp)Ap4A alpha S were 1:0.38:0.15, and the computed Km values for (Sp)ATP alpha S and (Rp)ATP alpha S were 0.48 and 1.34 mM, respectively. The yeast Ap4A phosphorylase synthesized (Sp)Ap4A alpha S and (Rp)Ap4A alpha S using adenosine 5'-phosphosulfate (APS) as source of adenylate. The adenylate was accepted by corresponding thioanalogues of ATP. In that system, relative velocities of Ap4A, (Sp)Ap4A alpha S and (Rp)Ap4A alpha S formation were 1:0.15:0.60. The two isomeric phosphorothioate analogues of Ap4A were tested as substrates for the following specific Ap4A-degrading enzymes: (asymmetrical) Ap4A hydrolase (EC 3.6.1.17) from yellow lupin (Lupinus luteus) seeds hydrolyzed each of the analogues to AMP and the corresponding isomer of ATP alpha S; (symmetrical) Ap4A hydrolase (EC 3.6.1.41) from E. coli produced ADP and the corresponding diastereomer of ADP alpha S; and Ap4A phosphorylase (EC 2.7.7.53) from S. cerevisiae cleaved the Rp isomer only at the unmodified end yielding ADP and (Rp)ATP alpha S whereas the Sp isomer was degraded non-specifically yielding a mixture of ADP, (Sp)ADP alpha S, ATP and (Sp)ATP alpha S. For all the Ap4A-degrading enzymes, the Rp isomer of Ap4A alpha S appeared to be a better substrate than its Sp counterpart; stereoselectivity of the three enzymes for the Ap4A alpha S diastereomers is 51, 6 and 2.5, respectively. Basic kinetic parameters of the degradation reactions are presented and structural requirements of the Ap4A-metabolizing enzymes with respect to the potential substrates modified at the Ap4A-P alpha are discussed. PMID:2172926

75 FR 57920 - Kerr-Philpott System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... schedules VA-1-B, VA-2-B, VA-3- B, VA-4-B, CP&L-1-B, CP&L-2-B, CP&L-3-B, CP&L-4-B, AP-1-B, AP-2-B, AP- 3-B..., CP&L-1-A, CP&L-2-A, CP&L-3-A, CP&L-4-A, AP-1-A, AP-2-A, AP-3-A, AP-4-A, NC-1-A, and Replacement-2... Schedules VA-1-A, VA-2-A, VA-3-A, VA-4-A, CP&L-1- A, CP&L-2-A, CP&L-3-A, CP&L-4-A, AP-1-A, AP-2-A, AP-3-A...

Statistical Evaluation of Airport Pavement Condition Survey Data for Washington, Oregon, and Idaho

DTIC Science & Technology

1988-01-01

21...COUNTY SQUIRE AIRPARK, OREGON 12 70 22...FLORENCE MUNICIPAL AP, OREGON 3 95 23...HERMISTON MUNICIPAL AP, OREGON 11 87 24...HOOD RIVER AP, OREGON...12 87 33...OROFINO MUNICIPAL AP, IDAHO 17 81 34...PRIEST RIVER MUNICIPAL AP, IDAHO 11 86 *NUgU**MmUU~tNUINNNNNNNffWUU0W NUU EU*UI** **-28 -28- TABLE 3...3 88 8...BAKER MUNICIPAL AP, OREGON 3 90 9...BEND MUNICIPAL AP, OREGON 9 89 10..CRESWELL MUNICIPAL AP, OREGON 1 98 11..HOOD RIVER AP, OREGON 1 96 12

Selected Proceedings from the Texas Foreign Language Education Conference 2001.

ERIC Educational Resources Information Center

Luke, Christopher, Ed.

2001-01-01

This collection of papers includes: "Language Learning Motivation: The Student, the Teacher, and the Researcher" (Robert C. Gardner); "The Self-Reported Perspectives Regarding Academic Writing among Taiwanese Graduate Students Specializing in TEFL" (Robert Johanson); "Contradictions, Appropriation, and Transformation: An…

A Constructive Induction Approach to Computer Immunology

DTIC Science & Technology

1999-03-01

LVM98] Lamont, Gary B., David A. Van Veldhuizen , and Robert E Marmelstein, A Distributed Architecture for a Self-Adaptive Computer Virus...Artificial Intelligence, Herndon, VA, 1995. [MVL98] Marmelstein, Robert E., David A. Van Veldhuizen , and Gary B. Lamont. Modeling & Analysis

75 FR 72935 - Apricots Grown in Designated Counties in Washington; Temporary Relaxation of the Minimum Grade...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... FURTHER INFORMATION CONTACT: Robert J. Curry or Gary D. Olson, Northwest Marketing Field Office, Marketing...: (503) 326-7440, or E-mail: Robert.Curry@ams.usda.gov or [email protected] . Small businesses may...

78 FR 56227 - Issuance of an Experimental Use Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... experimental use permit (EUP) to the pesticide applicant, Robert I. Rose, Ph.D., on behalf of James Mains, Ph.D.... Issuance. Robert I. Rose, Ph.D., on behalf of James Mains, Ph.D., Mosquito Mate, Inc., 1122 Oak Hill Drive...

Balancing Petroleum Force Structure/Capabilities between Active and Reserve Components

DTIC Science & Technology

2013-03-01

ORGANIZATION NAME(S) AND ADDRESS(ES) Colonel Robert M. Mundell Department of Command, Leadership, and Management 8. PERFORMING ORGANIZATION REPORT...Colonel Kenneth R. Hook United States Army Colonel Robert M. Mundell Department of Command, Leadership, and Management Project

Max Weber and Robert Michels.

ERIC Educational Resources Information Center

Scaff, Lawrence A.

1981-01-01

This paper investigates the unique intellectual partnership of Max Weber and Robert Michels, with particular emphasis on Weber's influence on Michel's inquiry into the sociology of parties and organization. Concludes with an evaluation of the import of Weber's critique of Michels' work. (DB)

75 FR 61985 - Airworthiness Directives; Boeing Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747-200F, 747...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... docket shortly after receipt. FOR FURTHER INFORMATION CONTACT: Robert Kaufman, Aerospace Engineer, Cabin.... Send information to Robert Kaufman, Aerospace Engineer, Cabin Safety and Environmental Systems Branch...

78 FR 45548 - South Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance...; 97.048, Disaster Housing Assistance to [[Page 45549

VizieR Online Data Catalog: Experimental spectrum of methanol (CH3OH) (McMillan+,

NASA Astrophysics Data System (ADS)

McMillan, J. P.; Fortman, S. M.; Neese, C. F.; de, Lucia F. C.

2017-05-01

In this paper we describe the spectrum of methanol between 214.6 and 265.4 GHz. In this region we observed 589 lines with scaled absorbance cross-sections greater than 0.0037 nm2. For comparison there are 386 lines in a composite catalog above this scaled absorbance cross-section. The spectrometer uses ax24 frequency multiplied probe, a heterodyne receiver, and a temperature controlled 6 m long cell (Fortman et al. 2010ApJ...725.1682F, 2011ApJ...737...20F). Four hundred eighty-six spectral scans were recorded as the temperature was ramped over a period of 305 minutes from 240 K to 389 K. The spectrum was recorded at 24.4140625 kHz intervals, with an integration time of ~18 us/bin. The temperatures were determined spectroscopically and are used as a part of the file name. The decontaminated absorbance spectra data are contained in 486 flat text files in this tarball. Each spectrum file contains 2.08 million data bins, starting at 214.6 GHz and incrementing in steps of 24.4140625 kHz. The frequency (in MHz) is provided in "tablefre.dat" and calibration data are provided in "tablecal.dat" (4 data files).

Diadenosine polyphosphates Ap3A and Ap4A, but not Ap5A or Ap6A, induce proliferation of vascular smooth muscle cells.

PubMed

Bobbert, Peter; Schlüter, Hartmut; Schultheiss, Heinz Peter; Reusch, Hans Peter

2008-05-15

Depending on the number of phosphate groups, diadenosine polyphosphates (ApnA, Ap3A, Ap4A, Ap5A and Ap6A) differ in properties such as proliferation, apoptosis, vasoconstriction and vasodilatation of vascular smooth muscle cells (VSMCs). Possible signaling pathways leading to effects such as proliferation are still unknown. This study examined the proliferative effects of diadenosine polyphosphates on VSMCs and their intracellular pathways. Proliferation of VSMCs was measured by the cell count and [(3)H] thymidine incorporation. Phosphorylation of the MAP kinases ERK1/2 was determined by Western blotting. Single-cell [Ca(2+)](i) measurements were done to determine the influence of [Ca(2+)](i) on intracellular signaling. Stress fiber formation was assessed by fluorescence microscopy to detect an influence of G alpha(12). Ap3A and Ap4A, but not Ap5A or Ap6A, were shown to increase proliferation of VSMCs by activating P2Y receptors, which leads to stimulation of the Ras-Raf-MEK-ERK1/2 cascade. Ap3A- and Ap4A-induced activation of the MAP kinases ERK1/2 was dependent on a signaling pathway that included the EGF receptor, PKC, PLCbeta and the increase of [Ca(2+)](i). In conclusion, Ap3A and Ap4A, but not Ap5A or Ap6A, induce proliferation of VSMCs by a signaling pathway that begins with activation of P2Y receptors and leads to stimulation of the MAP kinases ERK1/2.

Overexpression of Two PsnAP1 Genes from Populus simonii × P. nigra Causes Early Flowering in Transgenic Tobacco and Arabidopsis

PubMed Central

Zheng, Tangchun; Li, Shuang; Zang, Lina; Dai, Lijuan; Yang, Chuanping; Qu, Guan-Zheng

2014-01-01

In Arabidopsis, AP1 is a floral meristem identity gene and plays an important role in floral organ development. In this study, PsnAP1-1 and PsnAP1-2 were isolated from the male reproductive buds of poplar (Populus simonii × P. nigra), which are the orthologs of AP1 in Arabidopsis, by sequence analysis. Northern blot and qRT-PCR analysis showed that PsnAP1-1 and PsnAP1-2 exhibited high expression level in early inflorescence development of poplar. Subcellular localization showed the PsnAP1-1 and PsnAP1-2 proteins are localized in the nucleus. Overexpression of PsnAP1-1 and PsnAP1-2 in tobacco under the control of a CaMV 35S promoter significantly enhanced early flowering. These transgenic plants also showed much earlier stem initiation and higher rates of photosynthesis than did wild-type tobacco. qRT-PCR analysis further indicated that overexpression of PsnAP1-1 and PsnAP1-2 resulted in up-regulation of genes related to flowering, such as NtMADS4, NtMADS5 and NtMADS11. Overexpression of PsnAP1-1 and PsnAP1-2 in Arabidopsis also induced early flowering, but did not complement the ap1-10 floral morphology to any noticeable extent. This study indicates that PsnAP1-1 and PsnAP1-2 play a role in floral transition of poplar. PMID:25360739

Ap4A induces apoptosis in human cultured cells.

PubMed

Vartanian, A; Alexandrov, I; Prudowski, I; McLennan, A; Kisselev, L

1999-07-30

Diadenosine oligophosphates (Ap(n)A) have been proposed as intracellular and extracellular signaling molecules in animal cells. The ratio of diadenosine 5',5'''-P1,P3-triphosphate to diadenosine 5',5'''-P1,P4-tetraphosphate (Ap3A/Ap4A) is sensitive to the cellular status and alters when cultured cells undergo differentiation or are treated with interferons. In cells undergoing apoptosis induced by DNA topoisomerase II inhibitor VP16, the concentration of Ap3A decreases significantly while that of Ap4A increases. Here, we have examined the effects of exogenously added Ap3A and Ap4A on apoptosis and morphological differentiation. Penetration of Ap(n)A into cells was achieved by cold shock. Ap4A at 10 microM induced programmed cell death in human HL60, U937 and Jurkat cells and mouse VMRO cells and this effect appeared to require Ap4A breakdown as hydrolysis-resistant analogues of Ap4A were inactive. On its own, Ap3A induced neither apoptosis nor cell differentiation but did display strong synergism with the protein kinase C activators 12-deoxyphorbol-13-O-phenylacetate and 12-deoxyphorbol-13-O-phenylacetate-20-acetate in inducing differentiation of HL60 cells. We propose that Ap4A and Ap3A are physiological antagonists in determination of the cellular status: Ap4A induces apoptosis whereas Ap3A is a co-inductor of differentiation. In both cases, the mechanism of signal transduction remains unknown.

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

PubMed Central

Sitaram, Anand; Dennis, Megan K.; Chaudhuri, Rittik; De Jesus-Rojas, Wilfredo; Tenza, Danièle; Setty, Subba Rao Gangi; Wood, Christopher S.; Sviderskaya, Elena V.; Bennett, Dorothy C.; Raposo, Graça; Bonifacino, Juan S.; Marks, Michael S.

2012-01-01

Cell types that generate unique lysosome-related organelles (LROs), such as melanosomes in melanocytes, populate nascent LROs with cargoes that are diverted from endosomes. Cargo sorting toward melanosomes correlates with binding via cytoplasmically exposed sorting signals to either heterotetrameric adaptor AP-1 or AP-3. Some cargoes bind both adaptors, but the relative contribution of each adaptor to cargo recognition and their functional interactions with other effectors during transport to melanosomes are not clear. Here we exploit targeted mutagenesis of the acidic dileucine–based sorting signal in the pigment cell–specific protein OCA2 to dissect the relative roles of AP-1 and AP-3 in transport to melanosomes. We show that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position within the cytoplasmic domain. Mutants that preferentially bound either AP-1 or AP-3 each trafficked toward melanosomes and functionally complemented OCA2 deficiency, but AP-3 binding was necessary for steady-state melanosome localization. Unlike tyrosinase, which also engages AP-3 for optimal melanosomal delivery, both AP-1– and AP-3–favoring OCA2 variants required BLOC-1 for melanosomal transport. These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs. PMID:22718909

NASA Acting Administrator Robert Lightfoot All Hands

NASA Image and Video Library

2017-08-15

At NASA's Kennedy Space Center in Florida, agency Acting Administrator Robert Lightfoot and Deputy Associate Administrator Lesa Roe speak to employees during a town hall meeting in the conference room of Operations Support Building II. During the gathering, they updated progress on NASA programs.

Q & A with Ed Tech Leaders: Interview with Robert Talbert

ERIC Educational Resources Information Center

Shaughnessy, Michael F.; Yan, Juchao

2015-01-01

In this regular feature of "Educational Technology," Michael F. Shaughnessy and Juchao Yan present their interview with Robert Talbert, Associate Professor, Mathematics Department, Grand Valley State University, Allendale, Michigan. Their interview centered around thirteen questions that professor Talbert provided enlightening responds…

Morchella MLST database

USDA-ARS?s Scientific Manuscript database

Welcome to the Morchella MLST database. This dedicated database was set up at the CBS-KNAW Biodiversity Center by Vincent Robert in February 2012, using BioloMICS software (Robert et al., 2011), to facilitate DNA sequence-based identifications of Morchella species via the Internet. The current datab...

Mission, Science, and Race in South Africa; AW Roberts of Lovedale 1883-1938

NASA Astrophysics Data System (ADS)

Glass, I.S.

2016-02-01

Book Review: Biography of Alexander William Roberts. Noted educator, variable star observer and politician who represented South African "natives" in the parliament of the Union of South Africa at a time when they had no other representation.

76 FR 62085 - Pennsylvania; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... severity and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief....046, Fire Management Assistance Grant; [[Page 62086

Robert Frost and the Poetry of Physics.

ERIC Educational Resources Information Center

Coletta, W. John; Tamres, David H.

1992-01-01

Examines five poems by Robert Frost that illustrate Frost's interest in science. The poems include allusions to renowned physicists, metaphoric descriptions of some famous physics experiments, explorations of complementarity as enunciated by Bohr, and poetic formulations of Heisenberg's uncertainty principle. (20 references) (MDH)

2. Historic American Buildings Survey Robert J. Kelley, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Robert J. Kelley, Photographer May 1958 LOOKING NORTH - SHOWS SOUTH ELEVATION, MAIN HOUSE, ROOF OF NORTH ELEVATION AND WEST ELEVATION, WHOSE ROOF WAS RAISED IN RECENT TIMES - Burbank-Hatheway House, Main Street, Suffield, Hartford County, CT

Diadenosine tetraphosphate (Ap4A) and triphosphate (Ap3A) signaling of human sperm motility.

PubMed

Chan, P J; Su, B C; Tredway, D R

1991-01-01

The ubiquitous dinucleotide polyphosphate, diadenosine tetraphosphate (Ap4A), has been shown to be a signal molecule for DNA replication in mammalian cells. In this study, Ap4A and a related compound, diadenosine triphosphate (Ap3A), were tested for possible signaling functions in human spermatozoa. A computerized automated semen analyzer was used to detect changes in spermatozoa motility parameters. Cryopreserved-thawed donor spermatozoa were washed and incubated in 0.1 mM Ap4A, 0.1 mM Ap3A, or control medium. The data indicated that both Ap4A and Ap3A decreased the percentage of motile spermatozoa after 4 or more hours of incubation in vitro. The two dinucleotide polyphosphates caused an increase in the amplitude of lateral spermatozoa head displacement parameter only at the start of incubation. The other spermatozoa kinematic parameters were unaffected. No opposing ying-yang dual actions of Ap4A to Ap3A were seen. From the results, Ap4A and Ap3A were observed to be potential inhibitory signals of spermatozoa motility after prolonged exposure.

Diadenosine tetra- and pentaphosphates affect contractility and bioelectrical activity in the rat heart via P2 purinergic receptors.

PubMed

Pustovit, Ksenia B; Kuzmin, Vladislav S; Abramochkin, Denis V

2016-03-01

Diadenosine polyphosphates (Ap(n)As) are endogenously produced molecules which have been identified in various tissues of mammalian organism, including myocardium. Ap(n)As contribute to the blood clotting and are also widely accepted as regulators of blood vascular tone. Physiological role of Ap(n)As in cardiac muscle has not been completely elucidated. The present study aimed to investigate the effects of diadenosine tetra- (Ap4A) and penta- (Ap5A) polyphosphates on contractile function and action potential (AP) waveform in rat supraventricular and ventricular myocardium. We have also demonstrated the effects of A4pA and Ap5A in myocardial sleeves of pulmonary veins (PVs), which play a crucial role in genesis of atrial fibrillation. APs were recorded with glass microelectrodes in multicellular myocardial preparations. Contractile activity was measured in isolated Langendorff-perfused rat hearts. Both Ap4A and Ap5A significantly reduced contractility of isolated Langendorff-perfused heart and produced significant reduction of AP duration in left and right auricle, interatrial septum, and especially in right ventricular wall myocardium. Ap(n)As also shortened APs in rat pulmonary veins and therefore may be considered as potential proarrhythmic factors. Cardiotropic effects of Ap4A and Ap5A were strongly antagonized by selective blockers of P2 purine receptors suramin and pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS), while P1 blocker DPCPX was not effective. We conclude that Ap(n)As may be considered as new class of endogenous cardioinhibitory compounds. P2 purine receptors play the central role in mediation of Ap4A and Ap5A inhibitory effects on electrical and contractile activity in different regions of the rat heart.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Descartes, M.; Longshore, J.W.; Crawford, E.

We report an infant with double trisomy 48,XXX,+18, who also displayed features of Roberts syndrome. All previously published cases with similar double trisomy have presented with features of trisomy 18 syndrome. The chromosome analysis done at birth revealed the double trisomy; parental chromosomes were normal. The proband presented with microbrachycephaly, unilateral cleft lip and palate, choanal atresia, midfacial capillary hemanioma, thin nares, shallow orbits, malformed ears, sparse hair, hypomelia of the upper limbs, rocker-bottom feet, auricular septal defect and agenesis of the corpus callosum. Characteristic features of Roberts syndrome included hypomelia, midfacial defects, and severe growth deficiency. Among the manymore » different features reported in the literature for patients with trisomy 18 syndrome, the most consistent were growth deficiency, clenched fingers and congenital heart defects (e.g. VSD, ASD, PDA). Although some of our patient`s features such as cleft lip and cleft palate, low-set malformed ears, ASD, defects of the corpus callosum, choanal atresia, radial aplasia could also be seen in trisomy 18 syndrome (in 10-50% of the cases), her phenotype was more typical of Roberts syndrome because of symmetrical hypomelia and midfacial defects. Our patient`s chromosomes did not show premature separation of centromeric heterochromatin, a feature reported to occur in approximately one-half of individuals with Roberts syndrome. Sporadic aneuploidy involving different chromosomes has been found in lymphocyte cultures from some Roberts syndrome patients and is considered by some authors as a mitotic mutant. This aneuploidy is most likely to be chromosome gain. The simultaneous occurrence of trisomy X and 18 is extremely rare with only 11 cases having been reported in the literature. Our patient is unique since she has the double trisomy in addition to the characteristic features of Roberts syndrome.« less

GTARG - The TOPEX/Poseidon ground track maintenance maneuver targeting program

NASA Technical Reports Server (NTRS)

Shapiro, Bruce E.; Bhat, Ramachandra S.

1993-01-01

GTARG is a computer program used to design orbit maintenance maneuvers for the TOPEX/Poseidon satellite. These maneuvers ensure that the ground track is kept within +/-1 km with of an = 9.9 day exact repeat pattern. Maneuver parameters are determined using either of two targeting strategies: longitude targeting, which maximizes the time between maneuvers, and time targeting, in which maneuvers are targeted to occur at specific intervals. The GTARG algorithm propagates nonsingular mean elements, taking into account anticipated error sigma's in orbit determination, Delta v execution, drag prediction and Delta v quantization. A satellite unique drag model is used which incorporates an approximate mean orbital Jacchia-Roberts atmosphere and a variable mean area model. Maneuver Delta v magnitudes are targeted to precisely maintain either the unbiased ground track itself, or a comfortable (3 sigma) error envelope about the unbiased ground track.

Effects of the ultra-high pressure on structure and α-glucosidase inhibition of polysaccharide from Astragalus.

PubMed

Zhu, Zhen-Yuan; Luo, You; Dong, Guo-Ling; Ren, Yuan-Yuan; Chen, Li-Jing; Guo, Ming-Zhu; Wang, Xiao-Ting; Yang, Xue-Ying; Zhang, Yongmin

2016-06-01

A novel homogeneous polysaccharide fraction (APS) was extracted from Astragalus by hot water and purified by Sephadex G-100 and G-75 column. Its molecular weight was 693kDa. APS and APS with ultra-high pressure treatment exhibited significant inhibitory abilities on a-glucosidase, inhibition rate from high to low in order was 400MPa-APS, 300MPa-APS, 500MPa-APS and APS. The inhibition ​percentage of 400MPa-APS (1.5mg/mL) was 49% (max.). This suggested that the inhibitory activity of APS on a-glucosidase was improved by ultra-high pressure treatment. FT-IR, SEM, CD spectra, atomic force microscope and Congo red test analysis of APS and 400MPa-APS showed ultra-high pressure treatment didn't change the preliminary structure but had an effect on its advanced structure. Copyright © 2016 Elsevier B.V. All rights reserved.

Almost All Antipsychotics Result in Weight Gain: A Meta-Analysis

PubMed Central

Bak, Maarten; Fransen, Annemarie; Janssen, Jouke; van Os, Jim; Drukker, Marjan

2014-01-01

Introduction Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses generally are restricted to second generation antipsychotics (SGA) and do not stratify for duration of AP use. It is hypothesised that patients gain more weight if duration of AP use is longer. Method A meta-analysis was conducted of clinical trials of AP that reported weight change. Outcome measures were body weight change, change in BMI and clinically relevant weight change (7% weight gain or loss). Duration of AP-use was stratified as follows: ≤6 weeks, 6–16 weeks, 16–38 weeks and >38 weeks. Forest plots stratified by AP as well as by duration of use were generated and results were summarised in figures. Results 307 articles met inclusion criteria. The majority were AP switch studies. Almost all AP showed a degree of weight gain after prolonged use, except for amisulpride, aripiprazole and ziprasidone, for which prolonged exposure resulted in negligible weight change. The level of weight gain per AP varied from discrete to severe. Contrary to expectations, switch of AP did not result in weight loss for amisulpride, aripiprazole or ziprasidone. In AP-naive patients, weight gain was much more pronounced for all AP. Conclusion Given prolonged exposure, virtually all AP are associated with weight gain. The rational of switching AP to achieve weight reduction may be overrated. In AP-naive patients, weight gain is more pronounced. PMID:24763306

Almost all antipsychotics result in weight gain: a meta-analysis.

PubMed

Bak, Maarten; Fransen, Annemarie; Janssen, Jouke; van Os, Jim; Drukker, Marjan

2014-01-01

Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses generally are restricted to second generation antipsychotics (SGA) and do not stratify for duration of AP use. It is hypothesised that patients gain more weight if duration of AP use is longer. A meta-analysis was conducted of clinical trials of AP that reported weight change. Outcome measures were body weight change, change in BMI and clinically relevant weight change (7% weight gain or loss). Duration of AP-use was stratified as follows: ≤6 weeks, 6-16 weeks, 16-38 weeks and >38 weeks. Forest plots stratified by AP as well as by duration of use were generated and results were summarised in figures. 307 articles met inclusion criteria. The majority were AP switch studies. Almost all AP showed a degree of weight gain after prolonged use, except for amisulpride, aripiprazole and ziprasidone, for which prolonged exposure resulted in negligible weight change. The level of weight gain per AP varied from discrete to severe. Contrary to expectations, switch of AP did not result in weight loss for amisulpride, aripiprazole or ziprasidone. In AP-naive patients, weight gain was much more pronounced for all AP. Given prolonged exposure, virtually all AP are associated with weight gain. The rational of switching AP to achieve weight reduction may be overrated. In AP-naive patients, weight gain is more pronounced.

Robert Burk Gives Inaugural Wacholder Lecture on HPV and cervical cancer research

Cancer.gov

In April 2018, DCEG welcomed Robert Burk, M.D., as the inaugural Sholom Wacholder Distinguished Lecturer in Quantitative Health Sciences. The lectureship is named in memory of Dr. Sholom Wacholder, who worked at the intersection of quantitative reasoning and science.

Evaluation Report III: The Robert Noyce Scholarship Program at CSUB

ERIC Educational Resources Information Center

Wang, Jianjun

2013-01-01

California State University, Bakersfield (CSUB) received funding from National Science Foundation's (NSF) Robert Noyce Teacher Scholarship Program to recruit Noyce Scholars from upper-division science, technology, engineering, and mathematics (STEM) majors, graduate students, and professionals switched to STEM teaching from other fields (NSF…

Robert Weinberg: Scientist of the Year.

ERIC Educational Resources Information Center

Langone, John

1983-01-01

Highlights the background, career, and major accomplishments of Robert Allan Weinberg, professor of Biology at the Massachusetts Institute of Technology. His accomplishments and research interests focus on oncogenes, genes capable of causing cancer. The discovery of these genes has revealed the central mechanism of cancer. (Author/JN)

78 FR 62648 - Cat Island National Wildlife Refuge; West Feliciana Parish, Louisiana

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... comments, questions, and requests for information to: Robert Strader, Project Leader, USFWS, Lower... Paduani, Project Planner, 662-323-5548, [email protected] or Robert Strader, Project Leader, 601... conserve, enhance, and restore the historic native bottomland community characteristics of the lower...

The Legacy of Robert M. Gagne.

ERIC Educational Resources Information Center

Richey, Rita C., Ed.

This book highlights and discusses the contributions of Robert M. Gagne to the field of instructional technology. Section One presents the core concepts of Gagne's theory and contains reprints of the following five journal articles by Gagne: "Contributions of Learning to Human Development,""Learning Hierarchies,""Domains…

Official portrait of astronaut Robert D.Cabana

NASA Technical Reports Server (NTRS)

1985-01-01

Official portrait of astronaut Robert D.Cabana, a colonel in the United States Marine Corps (USMC) and a member of the 1985 Astronaut Class 11. Cabana is wearing a blue flight suit and poses with an American flag and asmall model of the space shuttle orbiter.

Robert Owen, William Maclure and New Harmony.

ERIC Educational Resources Information Center

Mclaren, David J.

1996-01-01

Discusses the utopian philosophy and related educational practices of the early 19th-century communitarian settlement in New Harmony, Indiana. The settlement failed after several years, due in no small part to the falling out between its two main supporters, Robert Owen and William Maclure. (MJP)

Robert Seymour Bridges om: Poet, physician and philosopher

PubMed Central

James, Theodore

1994-01-01

There has not been an English poet more interested in prosody nor physician more taken to medicine for its human contact, nor philosopher who lived closer to the tenets of his belief, than Robert Bridges (1844–1930). ImagesFigure 1.Figure 2. PMID:8207726

Rule of Law in Afghanistan -- Time for a New Approach?

DTIC Science & Technology

2009-03-17

accessed November 7 2008) 139 Gates, Robert M. Afghanistan Command Restructuring Worthy of Consideration. Texarkana , Texas, May 2, 2008 By Donna Miles...products/GAO-08-661 (accessed November 2 2008) Gates, Robert M. Afghanistan Command Restructuring Worthy of Consideration. Texarkana , Texas, May

1100398

NASA Image and Video Library

2011-03-24

CHARLES BOLDEN NASA ADMINISTRATOR TOURING AND SPEAKING AT THE US. SPACE AND ROCKET CENTER, HUNTSVILLE, ALABAMA. ACCOMPANYING ADMINISTRATOR BOLDEN ARE DR. DEBORAH BARNHART, CEO OF THE USSARC, ROBERT LIGHTFOOT, CENTER DIRECTOR OF MARSHALL SPACE FLIGHT CENTER AND RETIRED NASA ASTRONAUT ROBERT LEE “HOOT” GIBSON, ADMINISTRATOR BOLDEN’S FIRST SPACE FLIGHT COMMANDER.

78 FR 36557 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

76 FR 44031 - Arkansas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

78 FR 45549 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42... Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In Presidentially...

Robert Frost: Teacher "Earner, Learner, Yearner."

ERIC Educational Resources Information Center

Vogel, Nancy Sue

An account of Robert Frost's teaching, along with an assessment of it, are presented. Material consulted includes Frost's published letters, prose, and poetry; Lawrance Thompson's authorized biography; Lesley Frost's "New Hampshire's Child: The Derry Journals of Lesley Frost;" and additional sources such as films and periodicals,…

Underwater EVA training in the WETF with astronaut Robert L. Stewart

NASA Technical Reports Server (NTRS)

1983-01-01

Underwater extravehicular activity (EVA) training in the weightless environment training facility (WETF) with astronaut Robert L. Stewart. Stewart is simulating a planned EVA using the mobile foot restraint device and a one-G version of the Canadian-built remote manipulator system.

Identification of Major Enzymes Involved in the Synthesis of Diadenosine Tetraphosphate and/or Adenosine Tetraphosphate in Myxococcus xanthus.

PubMed

Kimura, Yoshio; Tanaka, Chihiro; Oka, Manami

2018-07-01

Myxococcus xanthus generates diadenosine tetraphosphates (Ap 4 A) and diadenosine pentaphosphates (Ap 5 A) under various stress conditions. M. xanthus lysyl-tRNA synthetase (LysS) efficiently synthesizes Ap 4 A from ATP, Ap 5 A from ATP and adenosine tetraphosphate (Ap 4 ), and Ap 4 from ATP and triphosphate. To identify other M. xanthus enzymes that can catalyze Ap 4 A and Ap 4 synthesis, 15 M. xanthus aminoacyl-tRNA synthetases (aaRSs), four acyl-CoA synthetases (Acys), three acetyl-CoA synthetases (Aces), phosphoglycerate kinase (Pgk), and adenylate kinase (Adk) were expressed in Escherichia coli and examined for Ap 4 A or Ap 4 synthetase activity using ATP or ATP and triphosphate as substrates. Among the tested enzymes, LysS had the highest Ap 4 A synthetase activity. AlaRS, SerRS, and LeuRS1 showed high ADP synthetase activity with ATP as a substrate in the presence of pyrophosphatase, and also demonstrated the ability to produce Ap 4 from ATP and triphosphate in the absence of pyrophosphatase. Ap 4 formation by AlaRS, SerRS, and LeuRS1 was approximately 4- to 13-fold higher compared with that of Ap 4 A, suggesting that these enzymes prefer triphosphate over ATP as a substrate in the second reaction. Some of the recombinant M. xanthus Acys and Aces also synthesized Ap 4 from ATP and triphosphate. However, Pgk was capable of catalyzing the production of Ap 4 from ATP and 3-phosphoglycerate in the presence of Mg 2+ and did not require triphosphate, suggesting that this enzyme is mainly responsible for Ap 4 synthesis in M. xanthus.

Revealing the Universe

NASA Astrophysics Data System (ADS)

Cornell, James; Lightman, Alan

1983-05-01

Contributors include Owen Gingerich, Kenneth Bracher, Robert F. C. Vessot, Fred L. Whipple, Fred Franklin, Robert W. Noyes, Robert Rosner, Harvey Tananbaum, Alan P. Lightman, Walter H. G. Lewin, William H. Press, John Huchra, and George B. Field. Alan Lightman, a Fellow of the American Academy of Arts & Sciences since 1996, is adjunct professor of humanities at MIT. He is the author of several books on science, including "Ancient Light: Our Changing View of the Universe" (1991) and "Origins: The Lives and Worlds of Modern Cosmologists" (with R. Brawer, 1990). His works of fiction include "Einstein's Dreams" (1993), "The Diagnosis" (2000), which was a finalist for the National Book Award, and, most recently, "Reunion" (2003).

The creativity of Crumb: research on the effects of psychedelic drugs on the comic art of Robert Crumb.

PubMed

Jones, Matthew T

2007-09-01

This article investigates the influence of perception that is altered by psychedelic drugs on processes of creativity through a case study of the work of well-known comic artist Robert Crumb. Samples of Crumb's work before, during, and after the period of his use of psychedelic drugs are content analyzed and compared according to the categorization offered by Janiger and Dobkin de Rios (1989). The results of the comparison indicate that Robert Crumb's drug use significantly altered the stylistic approach of his artwork not only during the period of his drug use, but long after he had stopped using drugs.

MicroRNAs to Pathways in Prostate Cancer Progression

DTIC Science & Technology

2015-12-01

PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Dr. Robert Blelloch and Dr. Cassandra Belair email: Robert.Blelloch@ucsf.edu 5e. TASK...Budget period of: 09/30/2013-09/29/2014: Name  Robert Blelloch  Project  Role  PI  Research Identifier Nearest person month  1.2  Contribution to... Project :  Dr. Blelloch was responsible for overall  coordination of this  project .  He was involved in  the design, interpretation and publication of all

Clinical significance of the summating potential-action potential ratio and the action potential latency difference for condensation and rarefaction clicks in Meniere's disease.

PubMed

Ohashi, Toru; Nishino, Hirohito; Arai, Yoko; Hyodo, Makoto; Takatsu, Mitsuharu

2009-04-01

This study was aimed to elucidate the diagnostic significance of the summating potential (SP)-action potential (AP) ratio and the AP latency difference between condensation and rarefaction clicks (AP con-rar difference) in Meniere's disease. The AP and SP were recorded transtympanically in 67 patients with definite Meniere's disease. The SP/AP ratio and the AP con-rar difference were assessed in terms of 1) their interrelationship, 2) their relationship to hearing level, and 3) the rate of occurrence of abnormal values according to the stages of Meniere's disease. No correlation was found between the SP/AP ratio and the AP con-rar difference. Neither the SP/AP ratio in general nor the AP con-rar difference was correlated with the hearing level. However, enhanced values of the SP/AP ratio (0.35 or higher) were moderately correlated with the hearing level (r = 0.51), and their occurrence rate was 55.2%. An increased AP con-rar difference (0.13 ms or longer) was not correlated with the hearing level, and its occurrence rate was 50.2%; it appeared most frequently at stage 3 (p <0.05). An enhanced SP/AP ratio might not always indicate the presence of endolymphatic hydrops associated with an increase in endolymphatic pressure. An increased AP con-rar difference might reflect the presence of a biased basilar membrane resulting from an increased endolymphatic pressure, and hence it is diagnostically essential to simultaneously evaluate the SP/AP ratio and the AP con-rar difference.

76 FR 36000 - Rulemaking Petition: Independent Expenditure Reporting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... sent to the Federal Election Commission, Attn.: Robert M. Knop, Assistant General Counsel, 999 E [[Page... CONTACT: Mr. Robert M. Knop, Assistant General Counsel, or Ms. Cheryl A. F. Hemsley, Attorney, 999 E... FEDERAL ELECTION COMMISSION 11 CFR Part 109 [Notice 2011-09] Rulemaking Petition: Independent...

16. VIEW OF ROBERT VOGEL, CURATOR, DIVISION OF MECHANICAL & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. VIEW OF ROBERT VOGEL, CURATOR, DIVISION OF MECHANICAL & CIVIL ENGINEER, NATIONAL MUSEUM OF AMERICAN HISTORY, SMITHSONIAN INSTITUTION, SITTING IN ELEVATOR CAR. MR. VOGEL IS RESPONSIBLE FOR THE RELOCATION OF THE ELEVATOR TO THE SMITHSONIAN INSTITUTION - 72 Marlborough Street, Residential Hydraulic Elevator, Boston, Suffolk County, MA

Supreme Court Roundup

ERIC Educational Resources Information Center

Williams, Charles F.

2005-01-01

Reactions to the retirement of Justice Sandra Day O'Connor and debate over the president's replacement nomination, Judge John Roberts, Jr., of the D.C. Circuit, dominated this summer's Supreme Court recess. Subsequently, after Chief Justice William H. Rehnquist's death on September 3, 2005, President Bush nominated Roberts for the chief justice…

Robert Frost, Teacher.

ERIC Educational Resources Information Center

Vogel, Nancy

This biography explores poet Robert Frost's techniques as a teacher from the early days of teaching at Pinkerton Academy in Derry, New Hampshire, to his acceptance of a chair at Harvard University and his subsequent associations with numerous other schools. Also examined are his educational practices and philosophy--particularly his life-long…

The Way Robert Sees It

ERIC Educational Resources Information Center

Freado, Mark D.; Wille, A. Katherine

2007-01-01

Robert, a fifteen-year-old resident in a residential treatment program, was diagnosed with significant hearing impairment. He communicates primarily through American Sign Language, although he speaks relatively well and has some hearing ability. Katie, a youth worker who has participated in Life Space Crisis Intervention (LSCI) training, worked…

76 FR 61757 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... become K-12 mathematics and science teachers. The program provides funds to institutions of higher... Foundation's (NSF) Robert Noyce Teacher Scholarship (Noyce) Program. Title of Collection: Evaluation of the Robert Noyce Teacher Scholarship Program. OMB Control No.: 3145-0217. Expiration Date of Approval: June...

ROBERT BOBO AND MIKE NICHOLS AT TEST STAND 4693

NASA Image and Video Library

2016-12-14

ROBERT BOBO, LEFT, AND MIKE NICHOLS TALK BENEATH THE 221-FOOT-TALL TEST STAND 4693, THE LARGEST OF TWO NEW SPACE LAUNCH SYSTEM TEST STANDS AT MSFC. BOBO MANAGES SLS STRUCTURAL STRENGTH TESTING, AND NICHOLS IS LEAD TEST ENGINEER FOR THE SLS LIQUID HYDROGEN TANK.

Suspended Substrate Resonator Design

DTIC Science & Technology

1990-12-01

1967. 10. Fred E. Gardiol, "Careful MIC Design Prevents Waveguide Modes", Microwaves, pp. 188-191, May 1977. 11. David Rubin and Alfred R. Hislop ...34Design Techniques for Sus- pended Substrate and Microstrip", Microwave Journal, October 1980 . 12. Robert Grover Brown, Robert A. Sharpe, William E. Post

The Ayes Have It.

ERIC Educational Resources Information Center

Keating, Tom

1996-01-01

Without procedural rules, school boards could not do business. Board members consulted revealed that they agree with the rules in theory but often do not follow them in practice. Lists 10 parliamentary rules to remember. Includes a brief biography of Henry M. Robert, who originated "Robert's Rules of Order." (MLF)

Remediating Language Deficient/Dyslexic College Students: An Interview with Robert Nash.

ERIC Educational Resources Information Center

Lundquist, Arlene J.; Nash, Robert

1988-01-01

Robert Nash responds to questions concerning his personal and professional background, the Simultaneous Multisensory Instructional Procedure for Teaching the Complete Sound Structure of the Language, problems associated with dyslexia, the social/emotional impact of learning disabilities, and the University of Wisconsin's Project Success for…

Robert Lowth and the Strong Verb System.

ERIC Educational Resources Information Center

van Ostade, Ingrid Tieken-Boon

2002-01-01

Traces the origin of the grammatical rule that strong verbs should distinguish between past tense and past participle forms. The rule, credited to Robert Lowth, did not in fact originate from Lowth nor did it reflect his usage as found in his private unpublished letters. (Author/VWL)

Publications - GMC 233 | Alaska Division of Geological & Geophysical

Science.gov Websites

Tidal Datum Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Geologic Hazards in geologic field program in Lower Cook Inlet, Alaska Authors: Roberts, Chuck, Coastal Science Laboratories publication sales page for more information. Bibliographic Reference Roberts, Chuck, Coastal Science

Stylistic Analysis of Robert Browning's Poem "Patriot into Traitor

ERIC Educational Resources Information Center

Ahmed, Mumtaz; Irshad, Ayesha

2015-01-01

The stylistic analysis of Robert Browning's poem "Patriot into Traitor" is done by using graphological, phonological, morphological and lexico-syntactic patterns. This analysis is helpful in decoding the underlying meanings of the poem. It clearly brings to surface what the poet really wants to impart.

NASA Acting Administrator Robert Lightfoot All Hands

NASA Image and Video Library

2017-08-15

At NASA's Kennedy Space Center in Florida, agency Acting Administrator Robert Lightfoot speaks to employees during a town hall meeting in the conference room of Operations Support Building II. To the right is Deputy Associate Administrator Lesa Roe. During the gathering, they updated progress on NASA programs.

Transformer Specification Language: A System for Generating Analyzers and Its Applications

DTIC Science & Technology

2011-01-01

like to thank present and former colleagues in PL group, Evan Driscoll, Aditya Thakur, Matt Elder, Tushar Sharma , Prathmesh Prabhu, Tycho Andersen, Emma...Robert Cohn, Robert Muth, Harish Patil, Artur Klauser, Geoff Lowney, Steven Wallace, Vijay Janapa Reddi, and Kim Hazelwood. Pin: building customized

Using "The Contender" by Robert Lipsyte.

ERIC Educational Resources Information Center

Christenbury, Leila

The novels of Robert Lipsyte are excellent for use in a middle school or secondary school classroom. His 1967 classic, "The Contender," and its sequel, "The Brave," are both strong on characterization, plot, and theme. Focusing on "The Contender," students can explore contending characters, forces, and themes. Related…

Robert Wilson's Invitation to Insanity.

ERIC Educational Resources Information Center

Stephens, Judith L.

The plays of stage director Robert Wilson are devices presenting alternative modes of perception to theatre audiences accustomed to verbal/aural structures of experience. Uniting his interests in the arts and therapy, his plays create a theatrical event promoting empathy with the perceptions of the mentally or physically handicapped and…

United States Navy Oceanic Armed Reconnaissance System

DTIC Science & Technology

2011-12-12

This report was prepared by: Rahul Petrie Daniel Reese Kurtis Hoots Robert Taylor Drew Nash Bunny Cooper Jonathan Trdan-Schmidt Marshall...NPS – Cohort 311-102S, Team OARS: Mr. Marshall Rice, Mr. Rahul Petrie, Mr. Daniel Reese, Mr. Kurtis Hoots, Mr. Robert Taylor, Mr. Drew Nash

75 FR 11112 - Action Affecting Export Privileges; Robert Kraaipoel

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Robert.... Take any action that facilitates the acquisition or attempted acquisition by the Denied Person of the... any action to acquire from or to facilitate the acquisition or attempted acquisition from the Denied...

Discovering Moral Engagement: An Interview with Robert Coles.

ERIC Educational Resources Information Center

Scott, Bradwell D.

1995-01-01

Educator Robert Coles argues that there is a need for a basis on which to teach and cultivate moral awareness in parents and children. Active parenting requires both inner-directed and outer-directed focuses to take advantage of the everyday events through which morality is developed. (SLD)

76 FR 33775 - Tennessee; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-09

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

76 FR 34090 - Missouri; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-10

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

78 FR 36556 - Oklahoma; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 41942 - Alaska; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C...; 97.048, Disaster Housing Assistance to Individuals and Households In Presidentially Declared Disaster...

78 FR 45547 - North Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 32414 - Illinois; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency..., Disaster Housing Assistance to Individuals and Households In Presidentially Declared Disaster Areas; 97.049...

77 FR 20043 - Indiana; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

75 FR 30419 - Kentucky; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

Robert Frost and the American College.

ERIC Educational Resources Information Center

Newdick, Robert S.

1999-01-01

The life and works of poet Robert Frost are examined for insights into his philosophy concerning higher education, particularly formal education, his own style of teaching, perceptions of the teacher's role within and outside the classroom, and the relationship between student and teacher. (Originally published in 1936) (MSE)

Influence of N-alkylation on organ distribution of radioiodinated amphetamines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Machulla, H.J.; Schmidt, U.; Mehdorn, H.M.

1985-05-01

In spite of numerous animal data and the widespread clinical application of p-(I-123)-N-isopropyl-amphetamine, questions remain open about the role of N-alkylation. Therefore, amphetamine (AP), N-methyl- (MeAP), and N-isopropyl-amphetamine (IsAP) were radioiodinated in the para position and the organ distribution was determined in male mice (Freiburg tribe) 10 weeks of age. In the lungs, all derivatives showed principally the same kinetics. In brain, the maximum uptake was reached after 30 min with 12%/g for AP and MeAP, and 10.5%/g for IsAP. In liver, the radioactivity similarly increased during the first 15 min to approx. 12%/g; afterwards, AP clearly decreased but MeAPmore » remained almost constant up to 120 min and, even more, IsAP increased to a maximum of 18%/g at 30 min. The same brain uptake kinetics for all 3 substances exclude the importance of lipophilicity increased by the N-alkylation. Furthermore, the differences in the liver kinetics of AP and both MeAP and IsAP indicate the importance of liver metabolism on the alkylated amphetamines. The results support the hypothesis that the first important metabolite of the N-alkylated derivatives is the amphetamine which accumulates in the brain as do MeAP and IsAP. On the basis of these findings, AP was applied clinically showing the same efficient brain uptake and distribution in SPECT as IsAP.« less

Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats.

PubMed

Sun, Deqing; Xue, Aiying; Zhang, Bin; Lou, Haiyan; Shi, Huanying; Zhang, Xiumei

2015-12-01

Acetylpuerarin (AP) is an acetylated derivative of puerarin (PUE). The study aimed to prepare polysorbate 80-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles to improve the permeability of AP across the blood-brain barrier (BBB) and enhance its brain-protective effects. AP-loaded PLGA nanoparticles (AP-PLGA-NPs) were prepared using a solvent diffusion methodology. The NPs were characterized. The pharmacokinetics, tissue distributions and brain-protective effects of AP-PLGA-NPs were evaluated in animals. AP-PLGA-NPs were successfully prepared with a mean particle size of 145.0 nm and a zeta potential of -14.81 mV. The in-vitro release of AP from the PLGA-NPs showed a biphasic release profile. AP was metabolized into PUE in rats. The AUC0-∞ values of AP and PUE for AP-PLGA-NPs were 2.90- and 2.29-fold as great as those for AP solution, respectively. The values of the relative targeting efficiency in the brain were 2.40 and 2.58 for AP and PUE, and the ratios of peak concentration were 1.91 and 1.89 for AP and PUE, respectively. Compared with the crude drug, AP-PLGA-NPs showed better brain-protective effects in rats. Polysorbate 80-coated PLGA-NPs can improve the permeability of AP cross the BBB and enhance its brain-protective effects in rats. © 2015 Royal Pharmaceutical Society.

Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon.

PubMed

Wang, Hao-Ven; Vaupel, Kristina; Buettner, Reinhard; Bosserhoff, Anja-Katrin; Moser, Markus

2004-09-01

AP-2 proteins comprise a family of highly related transcription factors, which are expressed during mouse embryogenesis in a variety of ectodermal, neuroectodermal, and mesenchymal tissues. AP-2 transcription factors were shown to be involved in morphogenesis of craniofacial, urogenital, neural crest-derived, and placental tissues. By means of a partial cDNA fragment identified during an expressed sequence tag search for AP-2 genes, we identified a fifth, previously unknown AP-2-related gene, AP-2 epsilon. AP-2 epsilon encodes an open reading frame of 434 amino acids, which reveals the typical modular structure of AP-2 transcription factors with highly conserved C-terminal DNA binding and dimerization domains. Although the N-terminally localized activation domain is less homologous, position and identity of amino acids essential for transcriptional transactivation are conserved. Reverse transcriptase-polymerase chain reaction analyses of murine embryos revealed AP-2 epsilon expression from gestational stage embryonic day 7.5 throughout all later embryonic stages until birth. Whole-mount in situ hybridization using a specific AP-2 epsilon cDNA fragment demonstrated that during embryogenesis, expression of AP-2 epsilon is mainly restricted to neural tissue, especially the midbrain, hindbrain, and olfactory bulb. This expression pattern was confirmed by immunohistochemistry with an AP-2 epsilon-specific antiserum. By using this antiserum, we could further localize AP-2 epsilon expression in a hypothalamic nucleus and the neuroepithelium of the vomeronasal organ, suggesting an important function of AP-2 epsilon for the development of the olfactory system.

Ectopic expression of Jatropha curcas APETALA1 (JcAP1) caused early flowering in Arabidopsis, but not in Jatropha

PubMed Central

Tang, Mingyong; Tao, Yan-Bin

2016-01-01

Jatropha curcas is a promising feedstock for biofuel production because Jatropha oil is highly suitable for the production of biodiesel and bio-jet fuels. However, Jatropha exhibits a low seed yield as a result of unreliable and poor flowering. APETALA1 (AP1) is a floral meristem and organ identity gene in higher plants. The flower meristem identity genes of Jatropha have not yet been identified or characterized. To better understand the genetic control of flowering in Jatropha, an AP1 homolog (JcAP1) was isolated from Jatropha. An amino acid sequence analysis of JcAP1 revealed a high similarity to the AP1 proteins of other perennial plants. JcAP1 was expressed in inflorescence buds, flower buds, sepals and petals. The highest expression level was observed during the early developmental stage of the flower buds. The overexpression of JcAP1 using the cauliflower mosaic virus (CaMV) 35S promoter resulted in extremely early flowering and abnormal flowers in transgenic Arabidopsis plants. Several flowering genes downstream of AP1 were up-regulated in the JcAP1-overexpressing transgenic plant lines. Furthermore, JcAP1 overexpression rescued the phenotype caused by the Arabidopsis AP1 loss-of-function mutant ap1-11. Therefore, JcAP1 is an ortholog of AtAP1, which plays a similar role in the regulation of flowering in Arabidopsis. However, the overexpression of JcAP1 in Jatropha using the same promoter resulted in little variation in the flowering time and floral organs, indicating that JcAP1 may be insufficient to regulate flowering by itself in Jatropha. This study helps to elucidate the function of JcAP1 and contributes to the understanding of the molecular mechanisms of flower development in Jatropha. PMID:27168978

The duality of LysU, a catalyst for both Ap4A and Ap3A formation.

PubMed

Wright, Michael; Boonyalai, Nonlawat; Tanner, Julian A; Hindley, Alison D; Miller, Andrew D

2006-08-01

Heat shock inducible lysyl-tRNA synthetase of Escherichia coli (LysU) is known to be a highly efficient diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) synthase. However, we use an ion-exchange HPLC technique to demonstrate that active LysU mixtures actually have a dual catalytic activity, initially producing Ap4A from ATP, before converting that tetraphosphate to a triphosphate. LysU appears to be an effective diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) synthase. Mechanistic investigations reveal that Ap3A formation requires: (a) that the second step of Ap4A formation is slightly reversible, thereby leading to a modest reappearance of adenylate intermediate; and (b) that phosphate is present to trap the intermediate (either as inorganic phosphate, as added ADP, or as ADP generated in situ from inorganic phosphate). Ap3A forms readily from Ap4A in the presence of such phosphate-based adenylate traps (via a 'reverse-trap' mechanism). LysU is also clearly demonstrated to exist in a phosphorylated state that is more physically robust as a catalyst of Ap4A formation than the nonphosphorylated state. However, phosphorylated LysU shows only marginally improved catalytic efficiency. We note that Ap3A effects have barely been studied in prokaryotic organisms. By contrast, there is a body of literature that describes Ap3A and Ap4A having substantially different functions in eukaryotic cells. Our data suggest that Ap3A and Ap4A biosynthesis could be linked together through a single prokaryotic dual 'synthase' enzyme. Therefore, in our view there is a need for new research into the effects and impact of Ap3A alone and the intracellular [Ap3A]/[Ap4A] ratio on prokaryotic organisms.

Changes in extracellular pH and myocardial ischaemia alter the cardiac effects of diadenosine tetraphosphate and pentaphosphate

PubMed Central

Stavrou, Brigitte M; Beck, Caroline; Flores, Nicholas A

2001-01-01

The structural conformation of diadenosine tetraphosphate (Ap4A) and pentaphosphate (Ap5A) has been reported to alter as pH is reduced. As such, it is possible that the cardiac effects of Ap4A and Ap5A vary during acidosis and myocardial ischaemia due to changes in ligand structure, receptor proteins or intracellular signalling. We investigated whether the cardiac electrophysiological and coronary vasomotor effects of Ap4A and Ap5A are preserved under conditions of extracellular acidosis (pH 6.5) and alkalosis (pH 8.5) and whether Ap4A has any electrophysiological or antiarrhythmic effects during ischaemia. Transmembrane right ventricular action potentials, refractory periods and coronary perfusion pressure were recorded from isolated, Langendorff-perfused guinea-pig hearts under constant flow conditions. The effects of 1 nM and 1 μM Ap4A and Ap5A were studied at pH 7.4, 6.5 and 8.5. The effects of 1 μM Ap4A were studied during global low-flow ischaemia and reperfusion. At pH 7.4, Ap4A and Ap5A increased action potential duration (APD95) and refractory period (RP) and reduced coronary perfusion pressure. The electrophysiological effects were absent at pH 6.5 while the reductions in perfusion pressure were attenuated. At pH 8.5, Ap4A increased RP but the effects of Ap4A and Ap5A on perfusion pressure were attenuated. During ischaemia, Ap4A had no antiarrhythmic or electrophysiological effects. These data demonstrate the importance of extracellular pH in influencing the effects of Ap4A and Ap5A on the heart and indicate that any potentially cardioprotective effects of these compounds during normal perfusion at physiological pH are absent during ischaemia. PMID:11588119

Functional Identification and Characterization of the Brassica Napus Transcription Factor Gene BnAP2, the Ortholog of Arabidopsis Thaliana APETALA2

PubMed Central

Xiong, Zhiyong; Chen, Chunli; Wang, Lijun; Yu, Jingyin; Lu, Changming; Wei, Wenhui

2012-01-01

BnAP2, an APETALA2 (AP2)-like gene, has been isolated from Brassica napus cultivar Zhongshuang 9. The cDNA of BnAP2, with 1, 299 bp in length, encoded a transcription factor comprising of 432 amino acid residues. Results from complementary experiment indicated that BnAP2 was completely capable of restoring the phenotype of Arabidopsis ap2-11 mutant. Together with the sequence and expression data, the complementation data suggested that BnAP2 encodes the ortholog of AtAP2. To address the transcriptional activation of BnAP2, we performed transactivation assays in yeast. Fusion protein of BnAP2 with GAL4 DNA binding domain strongly activated transcription in yeast, and the transactivating activity of BnAP2 was localized to the N-terminal 100 amino acids. To further study the function of BnAP2 involved in the phenotype of B. napus, we used a transgenic approach that involved targeted RNA interference (RNAi) repression induced by ihp-RNA. Floral various phenotype defectives and reduced female fertility were observed in B. napus BnAP2-RNAi lines. Loss of the function of BnAP2 gene also resulted in delayed sepal abscission and senescence with the ethylene-independent pathway. In the strong BnAP2-RNAi lines, seeds showed defects in shape, structure and development and larger size. Strong BnAP2-RNAi and wild-type seeds initially did not display a significant difference in morphology at 10 DAF, but the development of BnAP2-RNAi seeds was slower than that of wild type at 20 DAF, and further at 30 DAF, wild-type seeds were essentially at their final size, whereas BnAP2-RNAi seeds stopped growing and developing and gradually withered. PMID:22479468

Functional identification and characterization of the Brassica napus transcription factor gene BnAP2, the ortholog of Arabidopsis thaliana APETALA2.

PubMed

Yan, Xiaohong; Zhang, Lei; Chen, Bo; Xiong, Zhiyong; Chen, Chunli; Wang, Lijun; Yu, Jingyin; Lu, Changming; Wei, Wenhui

2012-01-01

BnAP2, an APETALA2 (AP2)-like gene, has been isolated from Brassica napus cultivar Zhongshuang 9. The cDNA of BnAP2, with 1, 299 bp in length, encoded a transcription factor comprising of 432 amino acid residues. Results from complementary experiment indicated that BnAP2 was completely capable of restoring the phenotype of Arabidopsis ap2-11 mutant. Together with the sequence and expression data, the complementation data suggested that BnAP2 encodes the ortholog of AtAP2. To address the transcriptional activation of BnAP2, we performed transactivation assays in yeast. Fusion protein of BnAP2 with GAL4 DNA binding domain strongly activated transcription in yeast, and the transactivating activity of BnAP2 was localized to the N-terminal 100 amino acids. To further study the function of BnAP2 involved in the phenotype of B. napus, we used a transgenic approach that involved targeted RNA interference (RNAi) repression induced by ihp-RNA. Floral various phenotype defectives and reduced female fertility were observed in B. napus BnAP2-RNAi lines. Loss of the function of BnAP2 gene also resulted in delayed sepal abscission and senescence with the ethylene-independent pathway. In the strong BnAP2-RNAi lines, seeds showed defects in shape, structure and development and larger size. Strong BnAP2-RNAi and wild-type seeds initially did not display a significant difference in morphology at 10 DAF, but the development of BnAP2-RNAi seeds was slower than that of wild type at 20 DAF, and further at 30 DAF, wild-type seeds were essentially at their final size, whereas BnAP2-RNAi seeds stopped growing and developing and gradually withered.

Alcohol Policies and Alcohol-Related Motor Vehicle Crash Fatalities Among Young People in the US.

PubMed

Hadland, Scott E; Xuan, Ziming; Sarda, Vishnudas; Blanchette, Jason; Swahn, Monica H; Heeren, Timothy C; Voas, Robert B; Naimi, Timothy S

2017-03-01

Motor vehicle crashes (MVCs) are a leading cause of death among young people in the United States. We examined the relationship between states' alcohol policy environments and alcohol-related MVC fatalities among children, adolescents, and young adults under the minimum legal drinking age of 21 years. We used the Alcohol Policy Scale (APS), an assessment of 29 alcohol policies across 50 states and Washington, DC, developed with the assistance of an interdisciplinary Delphi panel. Using the Fatality Analysis Reporting System, we examined APS scores in relation to fatalities of people ≤20 years old from 2000 to 2013 occurring in crashes in which ≥1 involved driver had a blood alcohol content ≥0.08%. Logistic regression was used with a 1-year lag between policies and MVC fatalities and adjusted for potential confounders. Of 84 756 MVC fatalities of those ≤20 years old during the study period, 23 757 (28.0%) were alcohol related, including deaths of 11 006 (46.3%) drivers, 10 212 (43.0%) passengers, and 2539 (10.7%) pedestrians, cyclists, and others. People killed in alcohol-related MVCs were predominantly male (72.7%) and older (65.5% were 18-20 years old), and 51.2% were non-Hispanic white. Restrictive policy environments were associated with fewer fatalities (adjusted odds ratio, 0.91 per 10-percentage-point increase in APS score; 95% confidence interval, 0.89-0.94). The association was observed for drivers and passengers, male and female decendents, and children, adolescents, and young adults. More restrictive alcohol policies are associated with reduced alcohol-related MVC mortality among young people. Studies should scrutinize the relationship between policies and fatalities to highlight mechanisms. Copyright © 2017 by the American Academy of Pediatrics.

In silico assessment of drug safety in human heart applied to late sodium current blockers

PubMed Central

Trenor, Beatriz; Gomis-Tena, Julio; Cardona, Karen; Romero, Lucia; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R; Saiz, Javier

2013-01-01

Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which may block different channels, remains an important opportunity. Partial block of the late sodium current (INaL) has emerged as a novel anti-arrhythmic mechanism. It can be effective in the settings of free radical challenge or hypoxia. In addition, this approach can attenuate pro-arrhythmic effects of blocking the rapid delayed rectifying K+ current (IKr). The main goal of our computational work was to develop an in-silico tool for preclinical anti-arrhythmic drug safety assessment, by illustrating the impact of IKr/INaL ratio of steady-state block of drug candidates on “torsadogenic” biomarkers. The O’Hara et al. AP model for human ventricular myocytes was used. Biomarkers for arrhythmic risk, i.e., AP duration, triangulation, reverse rate-dependence, transmural dispersion of repolarization and electrocardiogram QT intervals, were calculated using single myocyte and one-dimensional strand simulations. Predetermined amounts of block of INaL and IKr were evaluated. “Safety plots” were developed to illustrate the value of the specific biomarker for selected combinations of IC50s for IKr and INaL of potential drugs. The reference biomarkers at baseline changed depending on the “drug” specificity for these two ion channel targets. Ranolazine and GS967 (a novel potent inhibitor of INaL) yielded a biomarker data set that is considered safe by standard regulatory criteria. This novel in-silico approach is useful for evaluating pro-arrhythmic potential of drugs and drug candidates in the human ventricle. PMID:23696033

Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent.

PubMed

Hannes, Tobias; Wolff, Marie; Doss, Michael Xavier; Pfannkuche, Kurt; Haustein, Moritz; Müller-Ehmsen, Jochen; Sachinidis, Agapios; Hescheler, Jürgen; Khalil, Markus; Halbach, Marcel

2015-01-01

Modelling of cardiac development, physiology and pharmacology by differentiation of embryonic stem cells (ESCs) requires comparability of cardiac differentiation between different ESC lines. To investigate whether the outcome of cardiac differentiation is consistent between different ESC lines, we compared electrophysiological properties of ESC-derived cardiomyocytes (ESC-CMs) of different murine ESC lines. Two wild-type (D3 and R1) and two transgenic ESC lines (D3/aPIG44 and CGR8/AMPIGX-7) were differentiated under identical culture conditions. The transgenic cell lines expressed enhanced green fluorescent protein (eGFP) and puromycin-N-acetyltransferase under control of the cardiac specific α-myosin heavy chain (αMHC) promoter. Action potentials (APs) were recorded using sharp electrodes and multielectrode arrays in beating clusters of ESC-CMs. Spontaneous AP frequency and AP duration (APD) as well as maximal upstroke velocity differed markedly between unpurified CMs of the four ESC lines. APD heterogeneity was negligible in D3/aPIG44, moderate in D3 and R1 and extensive in CGR8/AMPIGX-7. Interspike intervals calculated from long-term recordings showed a high degree of variability within and between recordings in CGR8/AMPIGX-7, but not in D3/aPIG44. Purification of the αMHC+ population by puromycin treatment posed only minor changes to APD in D3/aPIG44, but significantly shortened APD in CGR8/AMPIGX-7. Electrophysiological properties of ESC-CMs are strongly cell line-dependent and can be influenced by purification of cardiomyocytes by antibiotic selection. Thus, conclusions on cardiac development, physiology and pharmacology derived from single stem cell lines have to be interpreted carefully. © 2015 S. Karger AG, Basel.

Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium.

PubMed

Decker, Keith F; Heijman, Jordi; Silva, Jonathan R; Hund, Thomas J; Rudy, Yoram

2009-04-01

Computational models of cardiac myocytes are important tools for understanding ionic mechanisms of arrhythmia. This work presents a new model of the canine epicardial myocyte that reproduces a wide range of experimentally observed rate-dependent behaviors in cardiac cell and tissue, including action potential (AP) duration (APD) adaptation, restitution, and accommodation. Model behavior depends on updated formulations for the 4-aminopyridine-sensitive transient outward current (I(to1)), the slow component of the delayed rectifier K(+) current (I(Ks)), the L-type Ca(2+) channel current (I(Ca,L)), and the Na(+)-K(+) pump current (I(NaK)) fit to data from canine ventricular myocytes. We found that I(to1) plays a limited role in potentiating peak I(Ca,L) and sarcoplasmic reticulum Ca(2+) release for propagated APs but modulates the time course of APD restitution. I(Ks) plays an important role in APD shortening at short diastolic intervals, despite a limited role in AP repolarization at longer cycle lengths. In addition, we found that I(Ca,L) plays a critical role in APD accommodation and rate dependence of APD restitution. Ca(2+) entry via I(Ca,L) at fast rate drives increased Na(+)-Ca(2+) exchanger Ca(2+) extrusion and Na(+) entry, which in turn increases Na(+) extrusion via outward I(NaK). APD accommodation results from this increased outward I(NaK). Our simulation results provide valuable insight into the mechanistic basis of rate-dependent phenomena important for determining the heart's response to rapid and irregular pacing rates (e.g., arrhythmia). Accurate simulation of rate-dependent phenomena and increased understanding of their mechanistic basis will lead to more realistic multicellular simulations of arrhythmia and identification of molecular therapeutic targets.

A KCNQ1 Mutation Causes a High Penetrance for Familial Atrial Fibrillation

PubMed Central

Bartos, Daniel C.; Anderson, Jeffrey B.; Bastiaenen, Rachel; Johnson, Jonathan N.; Gollob, Michael H; Tester, David J.; Burgess, Don E.; Homfray, Tessa; Behr, Elijah R.; Ackerman, Michael J.; Guicheney, Pascale; Delisle, Brian P.

2012-01-01

Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its incidence is expected to grow. A genetic predisposition for AF has long been recognized, but its manifestation in these patients likely involves a combination of rare and common genetic variants. Identifying genetic variants that associate with a high penetrance for AF would represent a significant breakthrough for understanding the mechanisms that associate with disease. Method and Results Candidate gene sequencing in five unrelated families with familial AF identified the KCNQ1 missense mutation p.Arg231His (R231H). In addition to AF, several of the family members have abnormal QTc intervals, syncope, or experienced sudden cardiac arrest or death. KCNQ1 encodes the voltage-gated K+ channel that conducts the slowly activating delayed rectifier K+ current in the heart. Functional and computational analyses suggested that R231H increases KCNQ1 current (IKCNQ1) to shorten the atrial action potential (AP) duration. R231H is predicted to minimally affect ventricular excitability, but it prevented the increase in IKCNQ1 following PKA activation. The unique properties of R231H appeared to be caused by a loss in voltage-dependent gating. Conclusions The R231H variant causes a high penetrance for interfamilial early-onset AF. Our study indicates R231H likely shortens atrial refractoriness to promote a substrate for reentry. Additionally, R231H might cause abnormal ventricular repolarization by disrupting PKA activation of IKCNQ1. We conclude genetic variants, which increase IKs during the atrial AP, decrease the atrial AP duration, and/or shorten atrial refractoriness, present a high risk for interfamilial AF. PMID:23350853

Outcome of Acute Pancreatic and Peripancreatic Collections Occurring in Patients With Acute Pancreatitis.

PubMed

Manrai, Manish; Kochhar, Rakesh; Gupta, Vikas; Yadav, Thakur Deen; Dhaka, Narendra; Kalra, Naveen; Sinha, Saroj K; Khandelwal, Niranjan

2018-02-01

To study the outcome of acute collections occurring in patients with acute pancreatitis BACKGROUND:: There are limited data on natural history of acute collections arising after acute pancreatitis (AP). Consecutive patients of AP admitted between July 2011 and December 2012 were evaluated by imaging for development of acute collections as defined by revised Atlanta classification. Imaging was repeated at 1 and 3 months. Spontaneous resolution, evolution, and need for intervention were assessed. Of the 189 patients, 151 patients (79.9%) had acute collections with severe disease and delayed hospitalization being predictors of acute collections. Thirty-six patients had acute interstitial edematous pancreatitis, 8 of whom developed acute peripancreatic fluid collections, of which 1 evolved into pseudocyst. Among the 153 patients with acute necrotizing pancreatitis, 143 (93.4%) developed acute necrotic collection (ANC). Twenty-three of 143 ANC patients died, 21 had resolved collections, whereas 84 developed walled-off necrosis (WON), with necrosis >30% (P = 0.010) and Computed Tomographic Severity Index score ≥7 (P = 0.048) predicting development of WON. Of the 84 patients with WON, 8 expired, 53 patients required an intervention, and 23 were managed conservatively. Independent predictors of any intervention among all patients were Computed Tomographic Severity Index score ≥7 (P < 0.001) and interval between onset of pain to hospitalization >7 days (P = 0.04). Patients with severe AP and delayed hospitalization more often develop acute collections. Pancreatic pseudocysts are a rarity in acute interstitial pancreatitis. A majority of patients with necrotising pancreatitis will develop ANC, more than half of whom will develop WON. Delay in hospitalization and higher baseline necrosis score predict need for intervention.

Radiographic Investigation of the Distal Extension of Fractures Into the Articular Surface of the Tibia (The RIDEFAST Study).

PubMed

Marchand, Lucas S; Rane, Ajinkya A; Working, Zachary M; Jacobson, Lance G; Kubiak, Erik N; Higgins, Thomas F; Rothberg, David L

2017-12-01

To determine whether radiographic measurements are predictive of involvement of the distal tibia articular surface in tibial shaft fractures. Retrospective review. Academic Level-I trauma hospital. Two-hundred seventeen patients with tibial shaft fractures distal to the isthmus (OTA/AO: 42-A1-3; 42-B1-3; 42-C1-3; and 43-A1-3). Analysis of anteroposterior (AP) and lateral radiographs. The following parameters were measured: (1) angle between the predominant fracture line and the plane of the tibial plafond (α-angle), (2) length of the shaft fracture, (3) distance from the most inferior extent of the shaft fracture to the tibial plafond (DTP), (4) width of the tibial plafond, (5) width of the tibial isthmus, (6) ratio of fracture length to DTP (FTP), and (7) fibular fracture distance. Distal intra-articular involvement (DIA). A total of 217 patients were identified, 56 (26%) with DIA. The FTP ratio as measured on both the AP (odds ratio: 8.20, confidence interval, 4.26-17.22, P < 0.0001) and lateral radiographs (10.00, 4.78-23.23, <0.0001) was the most effective screening measurement for DIA. AP and lateral FTP ratios of 0.224 and 0.255, respectively, achieved a negative predictive value of 100%, eliminating the need for computed tomography in 16%-23% of injuries. Involvement of the distal articular surface in patients with distal tibial shaft fractures is significantly associated with fracture geometry and pattern. The FTP ratio may be used as an effective screening tool to rule out of intra-articular involvement. Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Online Kidney Position Verification Using Non-Contrast Radiographs on a Linear Accelerator with on Board KV X-Ray Imaging Capability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willis, David J.; Kron, Tomas; Hubbard, Patricia

2009-01-01

The kidneys are dose-limiting organs in abdominal radiotherapy. Kilovoltage (kV) radiographs can be acquired using on-board imager (OBI)-equipped linear accelerators with better soft tissue contrast and lower radiation doses than conventional portal imaging. A feasibility study was conducted to test the suitability of anterior-posterior (AP) non-contrast kV radiographs acquired at treatment time for online kidney position verification. Anthropomorphic phantoms were used to evaluate image quality and radiation dose. Institutional Review Board approval was given for a pilot study that enrolled 5 adults and 5 children. Customized digitally reconstructed radiographs (DRRs) were generated to provide a priori information on kidney shapemore » and position. Radiotherapy treatment staff performed online evaluation of kidney visibility on OBI radiographs. Kidney dose measured in a pediatric anthropomorphic phantom was 0.1 cGy for kV imaging and 1.7 cGy for MV imaging. Kidneys were rated as well visualized in 60% of patients (90% confidence interval, 34-81%). The likelihood of visualization appears to be influenced by the relative AP separation of the abdomen and kidneys, the axial profile of the kidneys, and their relative contrast with surrounding structures. Online verification of kidney position using AP non-contrast kV radiographs on an OBI-equipped linear accelerator appears feasible for patients with suitable abdominal anatomy. Kidney position information provided is limited to 2-dimensional 'snapshots,' but this is adequate in some clinical situations and potentially advantageous in respiratory-correlated treatments. Successful clinical implementation requires customized partial DRRs, appropriate imaging parameters, and credentialing of treatment staff.« less

Exploring the tolerability of spatiotemporally complex electrical stimulation paradigms.

PubMed

Nelson, Timothy S; Suhr, Courtney L; Lai, Alan; Halliday, Amy J; Freestone, Dean R; McLean, Karen J; Burkitt, Anthony N; Cook, Mark J

2011-10-01

A modified cortical stimulation model was used to investigate the effects of varying the synchronicity and periodicity of electrical stimuli delivered to multiple pairs of electrodes on seizure initiation. In this model, electrical stimulation of the motor cortex of rats, along four pairs of a microwire electrode array, results in an observable seizure with quantifiable electrographic duration and behavioural severity. Periodic stimuli had a constant inter-stimulus intervals across the two-second stimulus duration, whilst synchronous stimuli consisted of singular biphasic, bipolar pulses delivered to the four pairs of electrodes at precisely the same time for the entire two second stimulation period. In this way four combinations of stimulation were possible; periodic/synchronous (P/S), periodic/asynchronous (P/As), aperiodic/synchronous (Ap/S) and aperiodic/asynchronous (Ap/As). All stimulation types were designed with equal pulse width, current intensity and mean frequency of stimulation (60 Hz), standardizing net charge transfer. It was expected that the periodicity of the stimulus would be the primary determinant of seizure initiation and therefore severity and electrographic duration. However, the results showed that significant differences in both severity and duration only occurred when the synchronicity was altered. For periodic stimuli, synchronous delivery increased median seizure duration from 5 s to 13 s and increased median Racine severity from 1 to 3. In the aperiodic case, synchronous stimulus delivery increased median duration from 5.5 s to 11s and resulted in seizures of median severity 3 vs. 0 in the asynchronous case. These findings may have implications for the design of future neurostimulation waveform designs as higher numbers of electrodes and stimulator output channels become available in next generation implants. Copyright © 2011 Elsevier B.V. All rights reserved.

Loss of knee extensor torque complexity during fatiguing isometric muscle contractions occurs exclusively above the critical torque.

PubMed

Pethick, Jamie; Winter, Samantha L; Burnley, Mark

2016-06-01

The complexity of knee extensor torque time series decreases during fatiguing isometric muscle contractions. We hypothesized that because of peripheral fatigue, this loss of torque complexity would occur exclusively during contractions above the critical torque (CT). Nine healthy participants performed isometric knee extension exercise (6 s of contraction, 4 s of rest) on six occasions for 30 min or to task failure, whichever occurred sooner. Four trials were performed above CT (trials S1-S4, S1 being the lowest intensity), and two were performed below CT (at 50% and 90% of CT). Global, central, and peripheral fatigue were quantified using maximal voluntary contractions (MVCs) with femoral nerve stimulation. The complexity of torque output was determined using approximate entropy (ApEn) and the detrended fluctuation analysis-α scaling exponent (DFA-α). The MVC torque was reduced in trials below CT [by 19 ± 4% (means ± SE) in 90%CT], but complexity did not decrease [ApEn for 90%CT: from 0.82 ± 0.03 to 0.75 ± 0.06, 95% paired-samples confidence intervals (CIs), 95% CI = -0.23, 0.10; DFA-α from 1.36 ± 0.01 to 1.32 ± 0.03, 95% CI -0.12, 0.04]. Above CT, substantial reductions in MVC torque occurred (of 49 ± 8% in S1), and torque complexity was reduced (ApEn for S1: from 0.67 ± 0.06 to 0.14 ± 0.01, 95% CI = -0.72, -0.33; DFA-α from 1.38 ± 0.03 to 1.58 ± 0.01, 95% CI 0.12, 0.29). Thus, in these experiments, the fatigue-induced loss of torque complexity occurred exclusively during contractions performed above the CT. Copyright © 2016 the American Physiological Society.

Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes.

PubMed

Kiger, Michelle E; McCanta, Anthony C; Tong, Suhong; Schaffer, Michael; Runciman, Martin; Collins, Kathryn K

2016-01-01

Intermittent Wolff-Parkinson-White (WPW) syndrome is considered to have a lower risk of sudden death. Fewer data exist regarding electrophysiologic (EP) characteristics and the natural history of intermittent WPW in children. All patients with WPW age 1-18 years at a single institution (1996-2013) were reviewed. Patients with intermittent preexcitation were compared to those with loss of preexcitation on Holter/exercise testing and those with persistent preexcitation. High-risk accessory pathway (AP) was defined as AP effective refractory period (APERP), block cycle length, or shortest preexcited RR interval during atrial fibrillation ≤250 ms. A total of 295 patients were included: 226 (76.6%) persistent, 39 (13.2%) intermittent, and 30 (10.2%) loss of preexcitation Holter/exercise. There were no differences in symptoms between groups. Median interquartile range APERP was significantly longer in intermittent WPW (380 [320, 488] ms vs 320 [300, 350] ms persistent, 310 [290, 330] ms loss of preexcitation Holter/exercise; P = 0.0008). At baseline, there was no difference between groups in frequency of high-risk pathways. However, when isoproterenol values were included, high-risk pathways were more frequent among patients with loss of preexcitation on Holter/exercise (54% vs 16% persistent, 11% intermittent; P = 0.005). There was one death in a patient with loss of preexcitation on exercise testing, no EP study, and prior drug use. A second patient with persistent WPW and APERP 270 ms required resuscitation following a methadone overdose. Intermittent preexcitation in children does not connote a lower risk AP by EP criteria or reduced symptoms. The low number of pediatric WPW patients who develop preexcited atrial fibrillation or sudden death warrants larger studies to investigate these outcomes. ©2015 Wiley Periodicals, Inc.

Activation of the Arabidopsis B class homeotic genes by APETALA1.

PubMed

Ng, M; Yanofsky, M F

2001-04-01

Proper development of petals and stamens in Arabidopsis flowers requires the activities of APETALA3 (AP3) and PISTILLATA (PI), whose transcripts can be detected in the petal and stamen primordia. Localized expression of AP3 and PI requires the activities of at least three genes: APETALA1 (AP1), LEAFY (LFY), and UNUSUAL FLORAL ORGANS (UFO). It has been proposed that UFO provides spatial cues and that LFY specifies competence for AP3 and PI expression in the developing flower. To understand the epistatic relationship among AP1, LFY, and UFO in regulating AP3 and PI expression, we generated two versions of AP1 that have strong transcriptional activation potential. Genetic and molecular analyses of transgenic plants expressing these activated AP1 proteins show that the endogenous AP1 protein acts largely as a transcriptional activator in vivo and that AP1 specifies petals by regulating the spatial domains of AP3 and PI expression through UFO.

Anodal sensory nerve action potentials: From physiological understanding to potential clinical applicability.

PubMed

Leote, Joao; Pereira, Pedro; Cabib, Christopher; Cipullo, Federica; Valls-Sole, Josep

2016-06-01

Low-intensity electrical stimuli of digital nerves may generate a double peak potential (DPp), composed of a cathodal (caAP) and an anodal (anAP) potential in orthodromic recordings. We studied the effects on caAP and anAP of stimuli of variable intensity, duration, and frequency. We also applied a conditioning stimulus to study potential differences in recovery time. The anAP was obtained in 33 of 40 healthy subjects (82.5%) and 4 of 20 patients with various types of sensory neuropathies (20%). Changes in stimulus duration and intensity had reciprocal effects on the amplitude of the anAP and the caAP. There were significant differences in recovery time between caAP and anAP after a conditioning stimulus. The caAP and anAP are 2 interdependent waveforms generated by different effects of the same stimulus over axons at the verge of depolarization. Muscle Nerve 53: 897-905, 2016. © 2015 Wiley Periodicals, Inc.

Gender, Academics and Interscholastic Sports Participation at the School Level: A Gender-specific Analysis of the Relationship between Interscholastic Sports Participation and AP Enrollment

PubMed Central

Veliz, Philip; Shakib, Sohaila

2014-01-01

While literature demonstrates that interscholastic sports participation is associated with positive academic outcomes, this relationship is rarely analyzed at a macro-level (the school-level). To date, there is no research examining whether increases in schools’ female and male interscholastic sports participation rates is associated with increases in female and male AP enrollment rates. Using a national sample of 4,644 public high schools during the 2009-2010 school year, we test several gender-specific hypotheses linked with the association between schools’ sport participation rates and advanced placement enrollment rates (AP math, AP science, AP foreign language, and overall AP enrollment). The findings reveal that schools’ female and male sports participation rates have a positive association with schools’ female and male AP math, AP science, AP foreign language, and overall AP enrollment rates. Moreover, the findings suggest that females benefit more than males in regard to the positive relationship between interscholastic sports and AP enrollment. PMID:24910475

Functions of Adaptor Protein (AP)-3 and AP-1 in Tyrosinase Sorting from Endosomes to MelanosomesD⃞

PubMed Central

Theos, Alexander C.; Tenza, Danièle; Martina, José A.; Hurbain, Ilse; Peden, Andrew A.; Sviderskaya, Elena V.; Stewart, Abigail; Robinson, Margaret S.; Bennett, Dorothy C.; Cutler, Daniel F.; Bonifacino, Juan S.; Marks, Michael S.; Raposo, Graça

2005-01-01

Specialized cells exploit adaptor protein complexes for unique post-Golgi sorting events, providing a unique model system to specify adaptor function. Here, we show that AP-3 and AP-1 function independently in sorting of the melanocyte-specific protein tyrosinase from endosomes to the melanosome, a specialized lysosome-related organelle distinguishable from lysosomes. AP-3 and AP-1 localize in melanocytes primarily to clathrin-coated buds on tubular early endosomes near melanosomes. Both adaptors recognize the tyrosinase dileucine-based melanosome sorting signal, and tyrosinase largely colocalizes with each adaptor on endosomes. In AP-3-deficient melanocytes, tyrosinase accumulates inappropriately in vacuolar and multivesicular endosomes. Nevertheless, a substantial fraction still accumulates on melanosomes, concomitant with increased association with endosomal AP-1. Our data indicate that AP-3 and AP-1 function in partially redundant pathways to transfer tyrosinase from distinct endosomal subdomains to melanosomes and that the AP-3 pathway ensures that tyrosinase averts entrapment on internal membranes of forming multivesicular bodies. PMID:16162817

Advances in Bacterial Methionine Aminopeptidase Inhibition

PubMed Central

Helgren, Travis R.; Wangtrakuldee, Phumvadee; Staker, Bart L.; Hagen, Timothy J.

2016-01-01

Methionine aminopeptidases (MetAPs) are metalloenzymes that cleave the N-terminal methionine from newly synthesized peptides and proteins. These MetAP enzymes are present in bacteria, and knockout experiments have shown that MetAP activity is essential for cell life, suggesting that MetAPs are good antibacterial drug targets. MetAP enzymes are also present in the human host and selectivity is essential. There have been significant structural biology efforts and over 65 protein crystal structures of bacterial MetAPs are deposited into the PDB. This review highlights the available crystallographic data for bacterial MetAPs. Structural comparison of bacterial MetAPs with human MetAPs highlights differences that can lead to selectivity. In addition, this review includes the chemical diversity of molecules that bind and inhibit the bacterial MetAP enzymes. Analysis of the structural biology and chemical space of known bacterial MetAP inhibitors leads to a greater understanding of this antibacterial target and the likely development of potential antibacterial agents. PMID:26268344

Physiological responses and time-motion characteristics of 4-a-side small-sided game in young soccer players: the influence of different team formation methods.

PubMed

Köklü, Yusuf; Ersöz, Gülfem; Alemdaroğlu, Utku; Aşç, Alper; Ozkan, Ali

2012-11-01

The purpose of this study was to examine the influence of different team formation methods on the physiological responses to and time-motion characteristics of 4-a-side small-sided games (SSG4) in young soccer players. Thirty-two young soccer players (age 16.2 ± 0.7 years; height 172.9 ± 6.1 cm; body mass 64.1 ± 7.7 kg) voluntarily participated in this study. Anthropometric measurements, technical tests, and maximum oxygen uptake (V[Combining Dot Above]O2max) tests were carried out on the players. The SSG4 teams were then created using 4 different methods: according to the coaches' subjective evaluation (CE), technical scores (TS), V[Combining Dot Above]O2max (AP), and V[Combining Dot Above]O2max multiplied by TSs (CG). The teams thus created played 4 bouts of SSG4 at 2-day intervals. During the SSG4, heart rate (HR) responses, distance covered, and time spent in HRmax zones were recorded. In addition, rating of perceived exertion (RPE) and blood lactate level (La) were determined at the end of the last bout of each SSG4. Percent of HRmax (%HRmax), La, and RPE responses during SSG4 were significantly higher for teams chosen according to AP and CG compared with that according to CE and TS (p < 0.05). In addition, teams chosen by AP and CG spent significantly more time in zone 4 (>90% HRmax ) and covered a greater distance in the high-intensity running zone (>18 km·h) than did teams formed according to TS. Moreover, AP teams covered significantly greater total distance than TS teams did (p < 0.05). In conclusion, to spend more time in both the high-intensity HR zone and the high-intensity running zone, the teams in SSG4 should be formed according to the players' V[Combining Dot Above]O2max values or the values calculated using both the V[Combining Dot Above]O2max and technique scores.

Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score.

PubMed

Eze, Ikenna C; Imboden, Medea; Kumar, Ashish; von Eckardstein, Arnold; Stolz, Daiana; Gerbase, Margaret W; Künzli, Nino; Pons, Marco; Kronenberg, Florian; Schindler, Christian; Probst-Hensch, Nicole

2016-09-01

Exposure to ambient air pollution (AP) exposure has been linked to type 2 diabetes (T2D) risk. Evidence on the impact of T2D genetic variants on AP susceptibility is lacking. Compared to single variants, joint genetic variants contribute substantially to disease risk. We investigated the modification of AP and diabetes association by a genetic risk score (GRS) covering 63 T2D genes in 1524 first follow-up participants of the Swiss cohort study on air pollution and lung and heart diseases in adults. Genome-wide data and covariates were available from a nested asthma case-control study design. AP was estimated as 10-year mean residential particulate matter <10μm (PM10). We computed count-GRS and weighted-GRS, and applied PM10 interaction terms in mixed logistic regressions, on odds of diabetes. Analyses were stratified by pathways of diabetes pathology and by asthma status. Diabetes prevalence was 4.6% and mean exposure to PM10 was 22μg/m(3). Odds of diabetes increased by 8% (95% confidence interval: 2, 14%) per T2D risk allele and by 35% (-8, 97%) per 10μg/m(3) exposure to PM10. We observed a positive interaction between PM10 and count-GRS on diabetes [ORinteraction=1.10 (1.01, 1.20)], associations being strongest among participants at the highest quartile of count-GRS [OR: 1.97 (1.00, 3.87)]. Stronger interactions were observed with variants of the GRS involved in insulin resistance [(ORinteraction=1.22 (1.00, 1.50)] than with variants related to beta-cell function. Interactions with count-GRS were stronger among asthma cases. We observed similar results with weighted-GRS. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity. These results need confirmation in diabetes cohort consortia. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Characterization and subcellular localization of aminopeptidases in senescing barley leaves

NASA Technical Reports Server (NTRS)

Thayer, S. S.; Choe, H. T.; Rausser, S.; Huffaker, R. C.

1988-01-01

Four aminopeptidases (APs) were separated using native polyacrylamide gel electrophoresis of cell-free extracts and the stromal fractions of isolated chloroplasts prepared from primary barley (Hordeum vulgare L., var Numar) leaves. Activities were identified using a series of aminoacyl-beta-naphthylamide derivatives as substrates. AP1, 2, and 3 were found in the stromal fraction of isolated chloroplasts with respective molecular masses of 66.7, 56.5, and 54.6 kilodaltons. AP4 was found only in the cytoplasmic fraction. No AP activity was found in vacuoles of these leaves. It was found that 50% of the L-Leu-beta-naphthylamide and 25% of the L-Arg-beta-naphthylamide activities were localized in the chloroplasts. Several AP activities were associated with the membranes of the thylakoid fraction of isolated chloroplasts. AP1, 2, and 4 reacted against a broad range of substrates, whereas AP3 hydrolyzed only L-Arg-beta-naphthylamide. Only AP2 hydrolyzed L-Val-beta-naphthylamide. Since AP2 and AP3 were the only ones reacting against Val-beta-naphthylamide and Arg-beta-naphthylamide, respectively, several protease inhibitors were tested against these substrates using a stromal fraction from isolated chloroplasts as the source of the two APs. Both APs were sensitive to both metallo and sulfhydryl type inhibitors. Although AP activity decreased as leaves senesced, no new APs appeared on gels during senescence and none disappeared.

Next-generation transcriptome analysis in transgenic birch overexpressing and suppressing APETALA1 sheds lights in reproduction development and diterpenoid biosynthesis.

PubMed

Huang, Haijiao; Chen, Su; Li, Huiyu; Jiang, Jing

2015-09-01

Overexpression of BpAP1 could cause early flowering in birch. BpAP1 affected the expression of many flowering-related unigenes and diterpenoid biosynthesis in transgenic birch, and BpPI was a putative target gene of BpAP1. APETALA1 (AP1) is an MADS-box transcription factor that is involved in the flowering process in plants and has been a focus of genetic studies examining flower development. Here, we carried out transcriptome analysis of birch (Betula platyphylla Suk.), including BpAP1 overexpression lines, BpAP1 suppression lines, and non-transgenic line (NT). Compared with NT, we detected 8302 and 7813 differentially expressed unigenes in 35S::BpAP1 and 35S::BpAP1RNAi transgenic lines, respectively. Overexpression and suppression of BpAP1 in birch affected diterpenoid biosynthesis and altered expression of many flowering-related unigenes. Moreover, combining information from the RNA-seq database and the birch genome, we predicted downstream target genes of BpAP1. Among the 166 putative target genes of BpAP1, there was a positive correlation between BpAP1 and BpPI. These results provide references for further examining the relationship between BpAP1 and its target genes, and reveal that BpAP1 functions as a transcription regulator in birch.

Enhanced terrestrial weathering/runoff and surface ocean carbonate production during the recovery stages of the Paleocene-Eocene thermal maximum

NASA Astrophysics Data System (ADS)

Kelly, D. Clay; Zachos, James C.; Bralower, Timothy J.; Schellenberg, Stephen A.

2005-12-01

The carbonate saturation profile of the oceans shoaled markedly during a transient global warming event known as the Paleocene-Eocene thermal maximum (PETM) (circa 55 Ma). The rapid release of large quantities of carbon into the ocean-atmosphere system is believed to have triggered this intense episode of dissolution along with a negative carbon isotope excursion (CIE). The brevity (120-220 kyr) of the PETM reflects the rapid enhancement of negative feedback mechanisms within Earth's exogenic carbon cycle that served the dual function of buffering ocean pH and reducing atmospheric greenhouse gas levels. Detailed study of the PETM stratigraphy from Ocean Drilling Program Site 690 (Weddell Sea) reveals that the CIE recovery period, which postdates the CIE onset by ˜80 kyr, is represented by an expanded (˜2.5 m thick) interval containing a unique planktic foraminiferal assemblage strongly diluted by coccolithophore carbonate. Collectively, the micropaleontological and sedimentological changes preserved within the CIE recovery interval reflect a transient state when ocean-atmosphere chemistry fostered prolific coccolithophore blooms that suppressed the local lysocline to relatively deeper depths. A prominent peak in the abundance of the clay mineral kaolinite is associated with the CIE recovery interval, indicating that continental weathering/runoff intensified at this time as well (Robert and Kennett, 1994). Such parallel stratigraphic changes are generally consonant with the hypothesis that enhanced continental weathering/runoff and carbonate precipitation helped sequester carbon during the PETM recovery period (e.g., Dickens et al., 1997; Zachos et al., 2005).

Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.

PubMed

Laloi, Maryse; McCarthy, James; Morandi, Olivia; Gysler, Christof; Bucheli, Peter

2002-09-01

Aspartic proteinase (EC 3.4.23) activity plays a pivotal role in the degradation of Theobroma cacao L. seed proteins during the fermentation step of cacao bean processing. Therefore, this enzyme is believed to be critical for the formation of the peptide and amino acid cocoa flavor precursors that occurs during fermentation. Using cDNA cloning and northern blot analysis, we show here that there are at least two distinct aspartic proteinase genes ( TcAP1 and TcAP2) expressed during cacao seed development. Both genes are expressed early during seed development and their mRNA levels decrease towards the end of seed maturation. TcAP2 is expressed at a much higher level than TcAP1, although the expression of TcAP1 increases slightly during germination. The proteins encoded by TcAP1 and TcAP2 are relatively different from each other (73% identity). This, and the fact that the two corresponding genes have different expression patterns, suggests that the TcAP1 and TcAP2 proteins may have different functions in the maturing seeds and during germination. Because the TcAP2 gene is expressed at a much higher level during seed development than TcAP1, it is likely that the TcAP2 protein is primarily responsible for the majority of the industrially important protein hydrolysis that occurs during cacao bean fermentation. Finally, TcAP2 has been functionally expressed in the yeast Yarrowia lipolytica. The secreted recombinant protein is able to hydrolyse bovine haemoglobin at acidic pH and is sensitive to pepstatin A, confirming that TcAP2 encodes an aspartic proteinase, and strongly suggests that this gene encodes the well-characterized aspartic proteinase of mature cacao seeds.

Airpower and Gradual Escalation: Reconsidering the Conventional Wisdom

DTIC Science & Technology

2000-06-01

Argument Without End : In Search of Answers to the Vietnam Tragedy (New...1979); Robert S. McNamara, et al. Argument Without End : In Search of Answers to the Vietnam Tragedy (New York: PublicAffairs, 1999); McNamara with...Robert S., et al. Argument Without End : In Search of

78 FR 27996 - Notice of Intent To Repatriate Cultural Items: The Robert S. Peabody Museum of Archaeology...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-13

..., Phillips Academy, Andover, MA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Robert S. Peabody Museum of Archaeology, Phillips Academy, Andover, MA, in consultation with the..., Phillips Academy, Andover, MA 01810, telephone (978) 749-4490. SUPPLEMENTARY INFORMATION: Notice is here...

3. Historic American Buildings Survey Robert J. Kelley, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey Robert J. Kelley, Photographer May 1958 NORTH ELEVATION BUILT BY OLIVER PHELPS c. 1793 AND PROBABLY DESIGNED BY ASHER BENJAMIN (WHO ALSO MADE CHANGES ON MAIN HOUSE TO MAKE IT CONFORM WITH NEW ELEVATION) - Burbank-Hatheway House, Main Street, Suffield, Hartford County, CT

75 FR 22175 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-27

..., James Layfield, Dana O. Lundgren, Raymond Meza, Robert L. Moore, Charles Noll, George H. Southland..., Robert Key, Christopher D. Linden, Patrick W. Merkel, Gene M. Morris, James L. Putnam, Jr., Donald W.... Glaser, George Klopf, Luke R. Lafley, Brian K. La Joie, John L. Langill, Gregg A. Lindberg, John R...

Lydia J. Roberts's Nutrition Research and the Rhetoric of "Democratic" Science

ERIC Educational Resources Information Center

Jack, Jordynn

2009-01-01

This article examines nutritionist Lydia J. Roberts's use of the "democratic approach" as a rhetorical strategy both to build solidarity among scientists and to enact participatory research in a rural Puerto Rican community. This example suggests that participatory scientific methodologies are not necessarily democratic but may function…

75 FR 47062 - Advisory Committee on Disability Compensation; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

... Committee's review to Mr. Robert Watkins, Department of Veterans Affairs, Veterans Benefits Administration... meeting or seeking additional information should contact Mr. Watkins at (202) 461- 9214 or e-mail at Robert.Watkins@va.gov . Dated: July 29, 2010. By Direction of the Secretary. Vivian Drake, Acting...

75 FR 42773 - Notice of Inventory Completion: Robert S. Peabody Museum of Archaeology, Phillips Academy...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... Museum of Archaeology, Phillips Academy, Andover, MA AGENCY: National Park Service, Interior. ACTION... control of the Robert S. Peabody Museum of Archaeology, Phillips Academy, Andover, MA. The associated.... 3003(d)(3). The determinations in this notice are the sole responsibility of the museum, institution...

Of Postulates and Peccadillos: Robert Koch and Vaccine (Tuberculin) Therapy for Tuberculosis

DTIC Science & Technology

1993-01-01

E The Founders of Modern Medicine Walden 5 Koch. P, Weitere Mittheilungen uber emn Heftmittel gegen Publications. New York. 1939. p 73 Tuberculose ...uber emn Heilnitel gegen 45 Brock, T D Robert Koch. A Life in Medicine and Bacteriology ’ Tuberculose [Continuation of the announcement concerning a

"Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacob, Robert

Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

John Dewey and Robert Pirsig: An Invitation to "Fresh Seeing."

ERIC Educational Resources Information Center

Granger, David A.

While reading John Dewey's "Art as Experience" and Robert Pirsig's "Zen and the Art of Motorcycle Maintenance: An Inquiry into Values," a graduate student observed close affinities between what Dewey referred to as "experience" and Pirsig referred to as "quality." Both texts are concerned with cultivating…

The Roberts Court and Academic Freedom

ERIC Educational Resources Information Center

Rahdert, Mark C.

2007-01-01

Since President Bush named Chief Justice John G. Roberts Jr. and Justice Samuel A. Alito Jr. to the Supreme Court, speculation has run high as to where the new court may be headed. Citing three recent cases ("Morse v. Frederick", "Rumsfeld v. Forum for Academic and Institutional Rights, Inc." and "Garcetti v.…

The College Teaching of English.

ERIC Educational Resources Information Center

Gerber, John C., Ed.

Thirteen essays on the teaching of college English are included--(1) "Prospect" by John H. Fisher, (2) "The Study and Teaching of English" by William C. De Vane, (3) "Introductory Literature Courses" by Hoyt Trowbridge, (4) "General and Interdisciplinary Courses" by Robert C. Pooley, (5) "Freshman Composition" by Robert M. Gorrell, (6) "Advanced…

DefenseLink Feature: Travels with Gates

Science.gov Websites

Robert M. Gates said. Story Gates Connects NATO Afghanistan Effort With Terror Threat in Europe MUNICH , Germany, Feb. 10, 2008 - The war on terror in Afghanistan is Europe's war, too, Defense Secretary Robert M ministers during meetings in Vilnius, Lithuania. Story Pakistan Understands Terror Danger VILNIUS, Lithuania

Adaptive Explicitly Parallel Instruction Computing

DTIC Science & Technology

2000-12-16

New York, NY, 1984. ACM. [33] Robert P. Colwell, Robert P. Nix, John J. O’Donnell, David P. Papworth, and Paul K. Rodman . A VLIW architecture for a...C. Ebeling, editors, Research on Integrated Systems: Proceedings of the 1993 Symposium, pages 183–199, 1993. [50] J. Gailly and M. Adler . ZLIB

4. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1944 ('Fig. 4-D') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

3. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1874 ('Fig. 4-C') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

2. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1866 ('Fig 4-B') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

Defense.gov - Special Report

Science.gov Websites

FORUM - U.S. Defense Secretary Robert M. Gates addresses the audience as Canadian Minister of National issues that Defense Secretary Robert M. Gates and Canadian Defense Minister Peter MacKay discussed during a bilateral meeting here today. Story | Transcript U.S., Canadian Defense Chiefs Answer Afghanistan

Who Was Robert Lawson?

ERIC Educational Resources Information Center

Hearn, Michael Patrick

1997-01-01

Recounts the life and career of Robert Lawson, an author and illustrator who is neglected today but who was responsible for three very popular children's books in the 1930s and 1940s. States that he is still the only person ever to receive both the Caldecott Award and the Newbery Medal. (PA)

Plan Aggregation for Strong Cyclic Planning in Nondeterministic Domains

DTIC Science & Technology

2014-07-02

Plan Aggregation for Strong Cyclic Planning in Nondeterministic Domains Ron Alforda, Ugur Kuterc, Dana Naub, Robert P. Goldmanc aASEE/NRL...addresses: ronald.alford.ctr@nrl.navy.mil (Ron Alford), ukuter@sift.net ( Ugur Kuter), nau@cs.umd.edu (Dana Nau), rpgoldman@sift.net (Robert P. Goldman

[Book review] A field guide to western reptiles and amphibians (Second Edition, Revised), by Robert C. Stebbins and Roger Tory Peterson

USGS Publications Warehouse

Jennings, M.R.

1987-01-01

Review of: A Field Guide to Western Reptiles and Amphibians (Peterson Field Guides, No. 16). Robert C. Stebbins and Roger Tory Peterson. Houghton Mifflin; 2nd Revised edition (June 10, 1985). 448 pages. ISBN: 978-0395382530.

28. Historic American Buildings Survey Robert M. Vogel, Photographer October, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. Historic American Buildings Survey Robert M. Vogel, Photographer October, 1970 PHOTOCOPY OF AN 1877 VIEW OF THE CROWN AND EAGLE MILLS, AS SEEN FROM THE SOUTH From the collection of the Stanley Woolen Company, Uxbridge, Massachusetts - Crown & Eagle Mills, 123 Hartford Avenue East, North Uxbridge, Worcester County, MA

Democracy "Is" Working

ERIC Educational Resources Information Center

Owen-Smith, Jason; Scott, Christopher Thomas; McCormick, Jennifer B.

2012-01-01

As contemporary students of science and science policy, these authors find it hard to gainsay the easy abstractions of Hurlbut and Robert's commentary. "Good science is an achievement of a good society." They also share much common ground on the details. For instance, they endorse the majority of Hurlbut and Robert's thoughts with regard to the…

We Are Our Mothers' Daughters?

ERIC Educational Resources Information Center

Grady, Marilyn L.; LaCost, Barbara Y.

2004-01-01

Writing that makes one think, writing that enriches one's understanding of the past and present, that's what Cokie Roberts' book, "We Are Our Mothers' Daughters" provides, and that, too, is what the authors of this issue of the "Journal of Women in Educational Leadership" provide. Roberts' background as a news analyst covering politics, Congress…

Impact of a Robert Noyce Scholarship on STEM Teacher Recruitment

ERIC Educational Resources Information Center

Morrell, Patricia D.; Salomone, Stephanie

2017-01-01

Funding from the Robert Noyce Teacher Scholarship Program supports the University of Portland Noyce Scholars and Interns Program (University of Portland Noyce Program). This study examined the first 3 years of the University of Portland Noyce Program to determine its effectiveness in attracting science, technology, engineering, and mathematics…

Hours of Boredom, Moments of Terror: Temporal Desynchrony in Military and Security Force Operations

DTIC Science & Technology

2010-10-01

Administrative Science Quarterly 24 (1979), 285–306. 31 Robert A. Karasek and Tores Theorell , Healthy Work: Stress, Productivity and the...first symptoms of incipient failure. 30 Robert A. Karasek , “Job Demands, Job Decision Latitude and Mental Strain: Implications for Job Redesign

Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California

EPA Science Inventory

Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California Mark G. Cantwell, David R. Katz, Julia Sullivan, Robert P. Eganhouse, Monique M. Perron, Robert M. Burgess The Palos Verdes shelf is located off the Southern California coa...

Robert Henry Thurston: Professionalism and Engineering Education

ERIC Educational Resources Information Center

Nienkamp, Paul

2016-01-01

Robert Henry Thurston is presented in this article. He provides one the most significant examples of professionalizing engineering through innovative education and promoting scientific education practices in the late nineteenth century. The son of a draftsmen and steam engine mechanic, Thurston spent his early years in Providence, Rhode Island.…

Suicide Prevention: The Student Assistance Model.

ERIC Educational Resources Information Center

Taylor-Mearhoff, Cheryl

The Roberts Assistance Program (RAP), a model program for student assistance and suicide prevention established in 1988 by the Owen J. Roberts School District in Chester County, Pennsylvania provides services to students in kindergarten through grade 12. Core teams of school professionals from the high school and middle school have received…

Robert Green's "James IV:" Love, Power, and Justice.

ERIC Educational Resources Information Center

Hayashi, Tetsumaro

1984-01-01

How events of the late medieval period of Great Britain are depicted in Robert Greene's play, "The Scottish History of James the Fourth," is discussed. The play reflects the spirit of a time in which some began to claim that women were the intellectual equals of men. (RM)

A Corps of Naval Strategists.

DTIC Science & Technology

1983-06-01

p. 284. 6 4 Igor H. Ansoff , Roger P. Declerck and Robert L. Hayes, From Strategic Management, (New York: John Wiley and Sons, 1976) p. 39-40. 65 III...U.S. Government Printing Office, 1983. Ansoff , Igor H., Declerck, Roger P. and Hayes, Robert L., From Strategic Management, New York: John Wiley and

Using Performance as an Interpretive Strategy in Teaching Robert Browning's "My Last Duchess."

ERIC Educational Resources Information Center

Schevera, Nicholas

1997-01-01

Uses role-playing, dramatic monologues, and "tableaux vivant" to interpret Robert Browning's poem "My Last Duchess" in an introductory literature class at Westchester Community College. Notes that performative strategies illustrate connections in the poem that often remain unnoticed on a first reading. (PA)

1. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1856 ('Fig. 4-A') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

"Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

ScienceCinema

Jacob, Robert

2018-02-07

Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

Role of Reconnaissance in the Counterattack.

DTIC Science & Technology

2016-05-26

Bejing: Foreign Language Press, 1967), 107. Sun - Tzu , The Art of Warfare, translated by Robert Ames (New York: Ballantine Books, 1993), 113. 14 B.H...dhat: qissat hayati. Cairo, Egypt: al-Maktab al-Misri al-Hadith, 1985. Sun - Tzu . The Art of Warfare. Translated by Robert Ames. New York: Ballantine...39 Bibliography

The Decline of Air Assault Operations

DTIC Science & Technology

2016-05-26

Anthology (Carlisle Barracks: US Army War College, 2000), 6-7. 94 Clausewitz, 198; Sun Tzu , The Art of Warfare, trans. Robert Ames (New York...Encyclopedia of World War II. Santa Barbara: ABC-CLIO, 2004. Tzu , Sun . The Art of Warfare. Trans. Robert Ames. New York: Ballentine Books, 1993. 55... Bibliography ...................................................................................................................................51 iv

78 FR 51203 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

76 FR 32984 - Arkansas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

77 FR 69648 - Rhode Island; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 23278 - Rhode Island; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-18

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households in...

78 FR 45548 - Montana; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. Sec. Sec... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households in...

78 FR 32415 - South Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 38728 - Michigan; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 36557 - North Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In...

76 FR 61375 - Vermont; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

... declared a major disaster under the authority of the Robert T. Stafford Disaster Relief and Emergency... the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households in...

78 FR 51204 - Colorado; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 38727 - Vermont; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In...

78 FR 32415 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In...

76 FR 61729 - Massachusetts; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... severity and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

76 FR 72964 - Virginia; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

78 FR 32416 - Minnesota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

76 FR 60515 - Connecticut; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford Act''), as follows: I have declared a major disaster under the Robert T. Stafford Disaster Relief and... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

75 FR 30419 - Mississippi; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... major disaster declaration under the authority of the Robert T. Stafford Disaster Relief and Emergency... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

76 FR 44031 - Vermont; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

75 FR 65500 - North Carolina; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

... authority of the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... severity and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief... Grant; 97.048, Disaster Housing Assistance to Individuals and Households In Presidentially Declared...

77 FR 44648 - Florida; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

Lesson Plans on African History and Geography: A Teaching Resource.

ERIC Educational Resources Information Center

Hamilton, Robert E., Ed.

This document presents lesson plans for instruction concerning the history and geography of the continent of Africa. Topics include: (1) "The Challenge of Teaching African History and Culture" (Robert Hamilton); (2) "A Physical Overview of Africa" (Robert Hamilton and Kim Lilly); (3) "A Cultural Overview of Africa"…

Conceptualising Childhood: Robert Louis Stevenson's "A Child's Garden of Verses."

ERIC Educational Resources Information Center

Webb, Jean

2002-01-01

Discusses the construct of childhood in Robert Louis Stevenson's collection of poems, "A Child's Garden of Verses," by employing notions of child development drawn from Jean Piaget and Lev Vygotsky. Finds, from a literary perspective, Stevenson's collection located on the boundaries of romanticism and modernism. (BT)

The Federal Public Works Infrastructure Strategy Program - Federal Works Infrastructure R&D: A New Perspective

DTIC Science & Technology

1993-07-01

Strategy, please contact Robert A. Pietrowsky , Program Manager at: Institute for Water Resources Casey Building 7701 Telegraph Road Fort Belvoir, VA 22060...management responsibility under the direction of Dr. Eugene Z. Stakhiv, Chief, Policy and Special Studies Division and Mr. Robert A. Pietrowsky , Program

Prevention of Breast Cell Transformation by Blockade of the AP-1 Transcription Factor

DTIC Science & Technology

2000-10-01

Distribution Unlimited 13. ABSTRACT (Maximum 200 Words) In this study, we are investigating the role of AP- M in controlling breast cell growth and...serum and these growth factors depend on AP-1 to transduce proliferative signal. AP- M blockade induced by the expression of TAM67 inhibits breast...demonstrated that TAM67 inhibits basal AP-1 activity and AP- M activity stimulated by several different growth factors. We have also discovered that AP-1

77 FR 19229 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

...; Joint Shrimp and Deepwater Shrimp AP; Dolphin Wahoo AP; King and Spanish Mackerel AP; and Coral AP in... Recreational Information Program and discuss allocation issues. 5. King and Spanish Mackerel AP Meeting: April 24-25, 2012 Members of the King and Spanish Mackerel AP will meet from 1:30 p.m. on April 24, 2012...

An exploration of the experiences of recent graduates from an interprofessional foundation degree.

PubMed

Norrie, Caroline; Hasselder, Alison; Manning, Chris

2012-11-01

This short report describes a study which aimed to explore the experiences of newly qualified assistant practitioners (APs) from an interprofessional foundation degree in long-term conditions. Interviews were carried out with one cohort of newly qualified APs and their employee mentors, 6-9 months after the APs had re-entered full-time practice. Three major themes were identified after analysis of the interview transcripts: widened AP horizons, poor AP pay and conditions and friction between APs and their colleagues. The course was highly praised by the APs and their workplace mentors. Unfortunately, the workplace infrastructure needed to support the APs was reported to be inadequate.