Science.gov

Sample records for investigacion sin complicaciones

  1. Complicaciones gastrointestinales (PDQ®)—Versión para pacientes

    Cancer.gov

    Resumen de información revisada por expertos acerca del estreñimiento, impacción, obstrucción intestinal y diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.

  2. Revista Investigacion Educativa, 1992-1995.

    ERIC Educational Resources Information Center

    Revista Investigacion Educativa, 1995

    1995-01-01

    This document consists of the eight issues of the series "Revista Investigacion Educativa" published during the 4-year period 1992-1995. This review of educational investigation seeks to promote the exchange of information about empirical research in education. It is published semiannually, and includes reports of both quantitative and qualitative…

  3. Managing asbestos: Ten costly sins

    SciTech Connect

    Denson, F.A.; Onderick, W.A.

    1993-01-01

    This article describes how to build an ongoing, continuous, and improved asbestos management program. Asbestos management is one of the toughest jobs facing a plant or environmental engineer today; even seasoned engineers can make mistakes. Much confusion exists about how best to manage this issue, especially in plant settings. Whether the company is small, medium, or large, asbestos has the power to steal from profits if not managed properly. To help POWER readers examine their current asbestos management programs, here are 10 common errors that could be stopped or avoided by practicing preventive techniques. The 10 costly sins presented are not mutually exclusive, and they certainly are not all-inclusive. They are offered as a way to stimulate ideas on how to build an ongoing, continuous, and improved asbestos management program. These include Sin 1: No written policy. Sin 2: Lack of corporate guidance. Sin 3: Not complying with regulations. Sin 4: Not worrying about other respirable fibers. Sin 5: Lawsuits--not culpable. Sin 6: No visible emissions, no problems. Sin 7: Managing asbestos manually.

  4. Complicaciones gastrointestinales (PDQ®)—Versión para profesionales de salud

    Cancer.gov

    Resumen de información revisada por expertos acerca del estreñimiento, la retención fecal, la obstrucción intestinal y la diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.

  5. Complicaciones orales de la quimioterapia y la radioterapia (PDQ®)—Versión para pacientes

    Cancer.gov

    Resumen de información revisada por expertos acerca de las complicaciones orales, como la mucositis y la disfunción de la glándula salival, que se presentan en pacientes de cáncer tratados con quimioterapia y radioterapia dirigida a la cabeza y el cuello.

  6. The ethics of sin taxes.

    PubMed

    Green, Rebecca

    2011-01-01

    ABSTRACT The current global economic crisis is forcing governments to consider a variety of methods to generate funds for infrastructure. In the United States, smoking-related illness and an obesity epidemic are forcing public health institutions to consider a variety of methods to influence health behaviors of entire target groups. In this paper, the author uses a public health nursing model, the Public Health Code of Ethics (Public Health Leadership Society, 2002), the American Nurses' Association (ANA) Code of Ethics (2001), and other relevant ethical theory to weigh and balance the arguments for and against the use of sin taxes. A position advocating the limited use of sin taxes is supported as a reasonable stance for the public health professional.

  7. SIN tunnel junction as a temperature sensor

    NASA Astrophysics Data System (ADS)

    Golubev, D.; Kuzmin, Leonid S.; Willander, Magnus

    1999-04-01

    The current-voltage characteristics of a superconductor-normal metal tunnel junction (SIN) is very sensitive to the temperature of the normal metal. Therefore SIN junction can be used as a thermometer which can be conveniently integrated into more complicated devices, for example bolometers. We estimate the effect of different types of noise on the sensitivity of such a thermometer. Shot noise of the tunnel junction, amplifier noise and the noise related to the fluctuations of the heat flow through the junction are considered. The performance of the bolometer with SIN junction as a temperature sensor is also discussed.

  8. Complicaciones orales de la quimioterapia y la radioterapia (PDQ®)—Versión para profesionales de salud

    Cancer.gov

    Resumen de información revisada por expertos acerca de las complicaciones orales, como la mucositis y la disfunción de la glándula salival, que se presentan en pacientes de cáncer tratados con quimioterapia y radioterapia a la cabeza y el cuello.

  9. Original Sin and T. E. Hulme's Aesthetics

    ERIC Educational Resources Information Center

    Kishler, Thomas C.

    1976-01-01

    T. E. Hulme, a vigorous opponent of romanticism in art, poetry, and philosophy, insisted that the underlying flaw of the romantic view was its rejection of the dogma of Original Sin and the fall of man. His views are explored for the significant bearing they have on the development of aesthetic insight and indirectly on value and outlook.…

  10. Babar: Sin(2beta) With Charm

    SciTech Connect

    Grenier, P.; /Ecole Polytechnique /Clermont-Ferrand U.

    2006-04-12

    We present measurements of time-dependent CP asymmetries of neutral B decays to several charm and charmonium final states. Data have been collected with the BABAR detector at the PEP-II storage ring at the Stanford Linear Accelerator Center. In the absence of penguin contribution, the Standard Model predicts the time-dependent CP asymmetry parameters S and C are to be {eta}{sub CP} sin(2{beta}) and 0, respectively.

  11. [SIN census 2008: the nephrologist's workload].

    PubMed

    Quintaliani, Giuseppe; Postorino, Maurizio; Di Napoli, Anteo; Limido, Aurelio; Dal Canton, Antonio; Balducci, Alessandro; Contu, Bruno; Salomone, Mario; Nordio, Maurizio; Levialdi Ghiron, Jung Hee; Viglino, Giusto; Pizzarelli, Francesco; Coppo, Rosanna

    2011-01-01

    This paper reports on a first analysis of data of the second survey promoted by the Italian Society of Nephrology (SIN), with particular regard to data referring to the nephrologist's workload. The survey was carried out through a Web-based questionnaire that participants could fill in online between March and December 2010. The data were validated against those of the Italian Dialysis and Transplant Registry (RIDT) and therefore refer to 31 December 2008, the date of the last RIDT report. Accurate completion of the questionnaires and reminders were monitored by the presidents of the regional sections of the SIN and the regional registries' chairpersons under the coordination of four area managers and a census committee. The response to the survey represented 42% of all nephrology centers, treating about 50% of all dialysis patients in Italy. The response percentage varied widely among regions (from 5% to 100% of the centers). After exclusion of the three regions with responses below 10%, it reached 68%, which was sufficient to give an idea of the state of nephrology in Italy. However, due to this wide variability, it was not possible to make an overall comparison of the regional situations, hence data for complex and simple structures were assessed separately. Despite the limits due to the incomplete participation in the survey, this article provides a clear description of the state of nephrology in Italy. The results confirm the hypothesis presented in the work of Bocconi Cergas, namely that the nephrology market is broader than nephrologists are able to control. The work of the nephrologist, which still seems to be focused mainly on dialysis in its various forms, should be directed more towards the development of methods for early detection of kidney disease and close follow-up. The ultimate aim is the early diagnosis of kidney disease and hence prevention of its complications, so that the focus no longer needs to be on ESKD treatment systems. PMID:22167614

  12. El aprendizaje significativo en las ciencias al participar en proyectos de investigacion cientifica

    NASA Astrophysics Data System (ADS)

    Mora Polanco, Miguelena

    La ciencia es el eje fundamental a traves del cual se desarrollan las habilidades necesarias para el pensar cientifico que va a la busqueda del conocimiento cientifico. La intencion de este estudio fue indagar en el tema de investigacion cientifica desde el punto de vista de los participantes en los siguientes aspectos relacionados con la experiencia de investigacion cientifica: a) conceptos, b) proceso, c) destrezas y d) disposicion. Tambien se analizaron: a) las perspectivas del metodo cientifico, b) la estrategia de ensenanza, c) la cultura cientifica y d) la exposicion del proyecto investigativo en la Feria Cientifica; como parte del aprendizaje significativo de la ciencias de los participantes. Esta investigacion cualitativa propuso como diseno el estudio de caso. Los aspectos relacionados a la experiencia de participar en proyecto de investigacion cientifica son el fenomeno o caso bajo estudio. En el estudio participaron cinco (5) estudiantes egresados de escuela publica o privada que cursaban hasta el tercer ano de estudios universitarios, conducentes a un bachillerato en educacion secundaria en ciencias o en ciencias naturales. Las tecnicas utilizadas para recopilar los datos fueron: analisis de documentos del DEPR, revision de artefactos y entrevistas profundas. Para el analisis de los datos de las entrevistas se utilizo el modelo de Wolcott (1994). Del analisis de documentos del DEPR se identificaron areas a mejorar en las guias de las cartas circulares con relacion a la investigacion escolar y la feria cientifica. El analisis de los artefactos proveyo evidencia de como los internados, simposios e investigaciones fomentan el que los estudiantes se superen en el aspecto cognitivo, se conviertan en creadores del conocimiento, al hacer suyo los conceptos para poder explicarlos al publico. De las entrevistas los participantes manifestaron que la experiencia de investigacion fue una de aprendizaje significativo que los marco para toda la vida y les expandio su

  13. Corporate redemption and the seven deadly sins.

    PubMed

    Pearson, A E

    1992-01-01

    Competitive purgatory is the sorry state of too many formerly proud U.S. corporations. They are languishing from the devastating effects of seven familiar sins: inconsistent product quality; slow response to the marketplace; lack of innovative, competitive products; uncompetitive cost structure; inadequate employee involvement; unresponsive customer service; and inefficient resource allocation. To make matters worse, the maladies are mostly management-induced, and the remedies most managers are employing-shifting strategy, reallocating resources, focusing on operations--are proving ineffective. The cures don't address the cause of the disease: negative, risk-averse, bureaucratic work environments that flourished in decades of easy growth but today are undermining competitive performance. What's needed is a total reinvention of the soft side of the organization to produce a work environment that stresses speed, Spartanism, innovation, and marketplace focus. First, top managers must decide what their company stands for and convince their employees of this uniqueness. Second, they must set standards that drive their business to worldclass levels and be tough about enforcing and raising them. Third, they must push constantly to ensure that enough innovations take place to change the company's future significantly. Three other factors are crucial: the right talent, an effective reward system, and CEOs who can drive the desired changes personally. Creating a dynamic work environment is not easy: it takes perseverance, flexibility, and commitment. But these efforts will pay off: how people tackle problems, work together, and think about their jobs are the activities that make a company great. PMID:10118004

  14. [SIN census 2008: the management model].

    PubMed

    Quintaliani, Giuseppe; Postorino, Maurizio; Di Napoli, Anteo; Limido, Aurelio; Dal Canton, Antonio; Balducci, Alessandro; Contu, Bruno; Salomone, Mario; Nordio, Maurizio; Levialdi Ghiron, Jung Hee; Viglino, Giusto; Pizzarelli, Francesco; Coppo, Rosanna

    2012-01-01

    This paper reports the analysis of the second part of the data obtained from the second SIN census and illustrates the management model of the Italian dialysis centers, highlighting its strengths but also its limits. The census was carried out between March and December 2008 with a webbased survey using fillable PDF forms. The survey was validated by comparing the data with those sent to the Italian Dialysis and Transplant Register (Registro Italiano di Dialisi e Trapianti, RIDT) and hence it refers to December 31, 2008, the date of the last RIDT report. Forty-two percent of dialysis centers, which altogether take care of 50% of Italian dialysis patients, participated in the census. The participation percentage was very variable among Italian regions (from 5% to 100% of dialysis centers). By excluding the three regions with a participation rate below 10%, the survey reached a participation rate of 68% of all Italian dialysis centers and is therefore sufficient to give an estimate of the Italian dialysis situation. However, because of this variability it was not possible to compare regional situations, and the data were evaluated only by analyzing the ''complex'' and ''simple'' dialysis centers separately. The state of affairs of dialysis in Italy on the whole proved to be complicated. It is striking, for example, that 15% of the ''complex'' dialysis centers do not have their own hospital beds and some of them lack traceability programs. Noteworthy are also the increasing use of central venous catheters and the number of patients that need an ambulance to get to the dialysis center. Despite its limits due to the reduced participation in the census, this work offers a fair description of the state of affairs of dialysis in Italy, where there is certainly space for qualitative improvement. First of all, however, every effort should be made to implement and improve the use of the existing structures and to standardize protocols and behaviors in all Italian dialysis

  15. Students Informing Now (S.I.N.) Challenge the Racial State in California without Shame..."SIN Verguenza!"

    ERIC Educational Resources Information Center

    Educational Foundations, 2007

    2007-01-01

    On a cold and wet Friday night in January of 2006, thirteen undergraduate students gathered together in a small room on campus at the University of California, Santa Cruz (UCSC) to found Students Informing Now (S.I.N.). S.I.N. was created to support the AB 504 students, labeled in this country as "illegal aliens." Inspired by Paulo Freire's…

  16. Modos de produccion cientifica: Culturas y metodologias de investigacion en la Universidad de Cadiz

    NASA Astrophysics Data System (ADS)

    Gonzalez Ramos, Ana M.

    2004-12-01

    Este trabajo de investigacion supone un modelo teorico de caracter aplicado, que proporciona la oportunidad de evaluar la produccion cientifica de los investigadores. Se encuadra dentro de la tradiccion de la estadistica aplicada y la sociologia del conocimiento. Atiende especialmente a dos conjuntos de temas de interes, por una parte, las caracteristicas principales que determinan el nivel y tipo de produccion academica producida por las unidades de investigacion y por los propios investigadores; por otra, la utilizacion que se hace de los metodos y tecnicas de investigacion puesto que de ello tambien depende el modo de produccion cientifica. Los puntos novedosos de esta tesis son: la medicion cuantitativa del objeto de estudio, la suma de los productos y las condiciones externas a la produccion del conocimiento mas otros elementos internos como las caracteristicas de los investigadores y la metodologia utilizada para desarrollar sus trabajos; y, finalmente, el uso de las nuevas tecnologias. El aprovechamiento de los recursos estadisticos y las fuentes de informacion secundarias se complementan con el diseno propio de una encuesta donde se implementa las caracteristicas descritas en un capitulo anterior sobre los metodos cientificos mas idoneos descritos en los principales manuales y articulos cientificos desde distintas disciplinas de conocimiento. Dicha encuesta ha sido desarrollada como un programa propio y en base a los mas innovadores usos de la tecnologia en la metodologia de encuestas.

  17. Development and Validation of the Single Item Narcissism Scale (SINS)

    PubMed Central

    Konrath, Sara; Meier, Brian P.; Bushman, Brad J.

    2014-01-01

    Main Objectives The narcissistic personality is characterized by grandiosity, entitlement, and low empathy. This paper describes the development and validation of the Single Item Narcissism Scale (SINS). Although the use of longer instruments is superior in most circumstances, we recommend the SINS in some circumstances (e.g. under serious time constraints, online studies). Methods In 11 independent studies (total N = 2,250), we demonstrate the SINS' psychometric properties. Results The SINS is significantly correlated with longer narcissism scales, but uncorrelated with self-esteem. It also has high test-retest reliability. We validate the SINS in a variety of samples (e.g., undergraduates, nationally representative adults), intrapersonal correlates (e.g., positive affect, depression), and interpersonal correlates (e.g., aggression, relationship quality, prosocial behavior). The SINS taps into the more fragile and less desirable components of narcissism. Significance The SINS can be a useful tool for researchers, especially when it is important to measure narcissism with constraints preventing the use of longer measures. PMID:25093508

  18. The significance of the concept of sin for bioethics.

    PubMed

    Sievernich, Michael

    2005-08-01

    After a period during which the theological categories of sin and forgiveness were ignored or trivialized, presently these notions are being rediscovered. What could their impact be on bioethics, either in the narrow sense of medical ethics, or in the more encompassing sense of the ethics of the life sciences? This essay begins with describing the processes of transcending and ethitization, which gave rise to the biblical notion of sin. It portrays the theological foundation of sin in terms of a twofold refusal of proper relations to God and other humans. Through the practise of confession in the face of God (coram deo), sin is placed into a horizon of hope for forgiveness and reconciliation. The heuristic and hermeneutical significance of these categories results from their introducing a "surplus value," which transcends biological and ethical considerations. This additional dimension is illustrated in view of care (cura) for the injured, and in view of individual as well as collective willingness to forgive. PMID:16266971

  19. Strategies to alleviate original antigenic sin responses to influenza viruses

    PubMed Central

    Kim, Jin Hyang; Davis, William G.; Sambhara, Suryaprakash; Jacob, Joshy

    2012-01-01

    Original antigenic sin is a phenomenon wherein sequential exposure to closely related influenza virus variants reduces antibody (Ab) response to novel antigenic determinants in the second strain and, consequently, impairs the development of immune memory. This could pose a risk to the development of immune memory in persons previously infected with or vaccinated against influenza. Here, we explored strategies to overcome original antigenic sin responses in mice sequentially exposed to two closely related hemagglutinin 1 neuraminidase 1 (H1N1) influenza strains A/PR/8/34 and A/FM/1/47. We found that dendritic cell–activating adjuvants [Bordetella pertussis toxin (PT) or CpG ODN or a squalene-based oil-in-water nanoemulsion (NE)], upon administration during the second viral exposure, completely protected mice from a lethal challenge and enhanced neutralizing-Ab titers against the second virus. Interestingly, PT and NE adjuvants when administered during the first immunization even prevented original antigenic sin in subsequent immunization without any adjuvants. As an alternative to using adjuvants, we also found that repeated immunization with the second viral strain relieved the effects of original antigenic sin. Taken together, our studies provide at least three ways of overcoming original antigenic sin. PMID:22869731

  20. The human dark side: evolutionary psychology and original sin.

    PubMed

    Lee, Joseph; Theol, M

    2014-04-01

    Human nature has a dark side, something important to religions. Evolutionary psychology has been used to illuminate the human shadow side, although as a discipline it has attracted criticism. This article seeks to examine the evolutionary psychology's understanding of human nature and to propose an unexpected dialog with an enduring account of human evil known as original sin. Two cases are briefly considered: murder and rape. To further the exchange, numerous theoretical and methodological criticisms and replies of evolutionary psychology are explored jointly with original sin. Evolutionary psychology can partner with original sin since they share some theoretical likenesses and together they offer insights into the nature of what it means to be human.

  1. Measurement of Sin2(beta) with BaBar

    SciTech Connect

    Wright, D M

    2002-11-05

    We present updated results on time-dependent CP-violating asymmetries in neutral B decays to several CP eigenstates containing charmonium. In the Standard Model, the amplitude of these asymmetries is proportional to sin2{beta}. We measure sin2{beta} = 0.741 {+-} 0.067 (stat) {+-} 0.034 (syst) from a data sample of about 88 million {Lambda}(4S) {yields} B{bar B} decays collected with the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We have also measured CP-violating asymmetries in open charm, and penguin modes sensitive to sin2{beta}, which provide important consistency tests of the Standard Model.

  2. [Serotonin dysfunctions in the background of the seven deadly sins].

    PubMed

    Janka, Zoltán

    2003-11-20

    The symbolic characters of the Seven Deadly Sins can be traced from time to time in the cultural history of human mankind, being directly specified in certain artistic products. Such are, among others, the painting entitled "The Seven Deadly Sins and the Four Lost Things" by Hieronymus Bosch and the poems Divina Commedia and The Foerie Queene by Dante Alighieri and Edmund Spenser, respectively. However, there are several paragraphs referring to these behaviours of the Seven Deadly Sins in the Bible and in the dramas of William Shakespeare. The objective of the present review is to propose that dysfunctions in the central serotonergic system might be involved in the neurobiology of these 'sinful' behaviour patterns. Evidences indicate that behaviour traits such as Accidia (Sloth), Luxuria (Lust, Lechery), Superbia (Pride), Ira (Wrath, Anger), Invidia (Envy), Avaritia (Greed, Avarice), and Gula (Gluttony) can relate to the functional alterations of serotonin in the brain. Results of biochemical and molecular genetic (polymorphism) studies on the human serotonergic system (receptor, transporter, enzyme), findings of functional imaging techniques, effects of depletion (or supplementation) of the serotonin precursor tryptophan, data of challenge probe investigations directed to testing central serotonergic functions, alterations in the peripheral serotonin measures (platelet), and the changes in the CSF 5-hydroxy-indoleacetic acid content indicate such serotonergic involvement. Furthermore, results of animal experiments on behaviour change (aggressive, dominant or submissive, appetite, alcohol preference) attributed to serotonin status modification and the clinically evidenced therapeutic efficacy of pharmacological interventions, based on the modulation and perturbation of the serotonergic system (e.g. selective serotonin reuptake inhibitors), in treating the 'sinful' behaviour forms and analogous pathological states reaching the severity of psychiatric disorders

  3. [Serotonin dysfunctions in the background of the seven deadly sins].

    PubMed

    Janka, Zoltán

    2003-11-20

    The symbolic characters of the Seven Deadly Sins can be traced from time to time in the cultural history of human mankind, being directly specified in certain artistic products. Such are, among others, the painting entitled "The Seven Deadly Sins and the Four Lost Things" by Hieronymus Bosch and the poems Divina Commedia and The Foerie Queene by Dante Alighieri and Edmund Spenser, respectively. However, there are several paragraphs referring to these behaviours of the Seven Deadly Sins in the Bible and in the dramas of William Shakespeare. The objective of the present review is to propose that dysfunctions in the central serotonergic system might be involved in the neurobiology of these 'sinful' behaviour patterns. Evidences indicate that behaviour traits such as Accidia (Sloth), Luxuria (Lust, Lechery), Superbia (Pride), Ira (Wrath, Anger), Invidia (Envy), Avaritia (Greed, Avarice), and Gula (Gluttony) can relate to the functional alterations of serotonin in the brain. Results of biochemical and molecular genetic (polymorphism) studies on the human serotonergic system (receptor, transporter, enzyme), findings of functional imaging techniques, effects of depletion (or supplementation) of the serotonin precursor tryptophan, data of challenge probe investigations directed to testing central serotonergic functions, alterations in the peripheral serotonin measures (platelet), and the changes in the CSF 5-hydroxy-indoleacetic acid content indicate such serotonergic involvement. Furthermore, results of animal experiments on behaviour change (aggressive, dominant or submissive, appetite, alcohol preference) attributed to serotonin status modification and the clinically evidenced therapeutic efficacy of pharmacological interventions, based on the modulation and perturbation of the serotonergic system (e.g. selective serotonin reuptake inhibitors), in treating the 'sinful' behaviour forms and analogous pathological states reaching the severity of psychiatric disorders

  4. Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN.

    PubMed

    Wachowicz, Paulina; Chasapi, Anastasia; Krapp, Andrea; Cano Del Rosario, Elena; Schmitter, Daniel; Sage, Daniel; Unser, Michael; Xenarios, Ioannis; Rougemont, Jacques; Simanis, Viesturs

    2015-02-15

    The Schizosaccharomyces pombe septation initiation network (SIN) regulates cytokinesis, and asymmetric association of SIN proteins with the mitotic spindle pole bodies (SPBs) is important for its regulation. Here, we have used semi-automated image analysis to study SIN proteins in large numbers of wild-type and mutant cells. Our principal conclusions are: first, that the association of Cdc7p with the SPBs in early mitosis is frequently asymmetric, with a bias in favour of the new SPB; second, that the early association of Cdc7p-GFP to the SPB depends on Plo1p but not Spg1p, and is unaffected by mutations that influence its asymmetry in anaphase; third, that Cdc7p asymmetry in anaphase B is delayed by Pom1p and by activation of the spindle assembly checkpoint, and is promoted by Rad24p; and fourth, that the length of the spindle, expressed as a fraction of the length of the cell, at which Cdc7p becomes asymmetric is similar in cells dividing at different sizes. These data reveal that multiple regulatory mechanisms control the SIN in mitosis and lead us to propose a two-state model to describe the SIN.

  5. Paragonimiasis in Sin Ho District, Lai Chau Province, Viet Nam.

    PubMed

    Vien, C V; Phue, N C; Ha, L D; Tuan, L M; Van, N T; Pao, T C; Hoa, L T; Phoung, C T

    1997-01-01

    Forty-four cases of pulmonary paragonimiasis, two also with evidence of cerebral infection, were found in Sin Ho District in Northern Viet Nam. There were 30 males and 14 females, 2-30 years of age. The diagnosis was made by sputum examination. Pet dogs and wild dogs in the area were also found infected and the people often eat roasted crabs.

  6. Virtues of SIN: Can Intensified Public Efforts Help Disadvantaged Immigrants?

    ERIC Educational Resources Information Center

    Aslund, Olof; Johansson, Per

    2011-01-01

    The labor market integration of immigrants is a top political priority throughout the Organization for Economic Cooperation and Development (OECD) countries. Social and fiscal gains, as well as sustained future labor supply make governments search for effective policies to increase employment among the mostly disadvantaged. The author studies SIN,…

  7. Sin Nombre Virus Infection in Field Workers, Colorado, USA

    PubMed Central

    Torres-Pérez, Fernando; Wilson, Linda; Collinge, Sharon K.; Harmon, Heath; Ray, Chris; Medina, Rafael A.

    2010-01-01

    We report 2 cases of Sin Nombre virus (SNV) infection in field workers, possibly contracted through rodent bites. Screening for antibodies to SNV in rodents trapped in 2 seasons showed that 9.77% were seropositive. Quantitative real-time PCR showed that 2 of 79 deer mice had detectable titers of SNV RNA. PMID:20113567

  8. Structure and organisation of SinR, the master regulator of biofilm formation in Bacillus subtilis.

    PubMed

    Colledge, Vicki L; Fogg, Mark J; Levdikov, Vladimir M; Leech, Andrew; Dodson, Eleanor J; Wilkinson, Anthony J

    2011-08-19

    sinR encodes a tetrameric repressor of genes required for biofilm formation in Bacillus subtilis. sinI, which is transcribed under Spo0A control, encodes a dimeric protein that binds to SinR to form a SinR-SinI heterodimer in which the DNA-binding functions of SinR are abrogated and repression of biofilm genes is relieved. The heterodimer-forming surface comprises residues conserved between SinR and SinI. Each forms a pair of α-helices that hook together to form an intermolecular four-helix bundle. Here, we are interested in the assembly of the SinR tetramer and its binding to DNA. Size-exclusion chromatography with multi-angle laser light scattering and crystallographic analysis reveal that a DNA-binding fragment of SinR (residues 1-69) is a monomer, while a SinI-binding fragment (residues 74-111) is a tetramer arranged as a dimer of dimers. The SinR(74-111) chain forms two α-helices with the organisation of the dimer similar to that observed in the SinR-SinI complex. The tetramer is formed through interactions of residues at the C-termini of the four chains. A model of the intact SinR tetramer in which the DNA binding domains surround the tetramerisation core was built. Fluorescence anisotropy and surface plasmon resonance experiments showed that SinR binds to an oligonucleotide duplex, 5'-TTTGTTCTCTAAAGAGAACTTA-3', containing a pair of SinR consensus sequences in inverted orientation with a K(d) of 300 nM. The implications of these data for promoter binding and the curious quaternary structural transitions of SinR upon binding to (i) SinI and (ii) the SinR-like protein SlrR, which "repurposes" SinR as a repressor of autolysin and motility genes, are discussed.

  9. Jose Maria Albareda (1902-1966) and the Formation of the Spanish Consejo Superior de Investigaciones Cientificas

    ERIC Educational Resources Information Center

    Malet, Antoni

    2009-01-01

    Jose Maria Albareda (1902-1966) was an applied chemist and a prominent member of the Roman Catholic organization, Opus Dei, who played a crucial role in organizing the Consejo Superior de Investigaciones Cientficas (CSIC), the new scientific institution created by the Franco regime in 1939. The paper analyses first the formative years in…

  10. Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity

    PubMed Central

    Park, Mee Sook; Kim, Jin Il; Park, Sehee; Lee, Ilseob

    2016-01-01

    The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This adverse immunological effect can alter vaccine effectiveness and sometimes cause enhanced pathogenicity or additional inflammatory responses, according to the type of pathogen and the circumstances of infection. Here we aim to give a simplified conceptual understanding of virus infection and original antigenic sin by comparing and contrasting the two examples of recurring infections such as influenza and dengue viruses in humans. PMID:27799871

  11. Subgap conductivity in SIN-junctions of high barrier transparency

    NASA Astrophysics Data System (ADS)

    Lotkhov, S. V.; Balashov, D. V.; Khabipov, M. I.; Buchholz, F.-I.; Zorin, A. B.

    2006-11-01

    We investigate the current-voltage characteristics of high-transparency superconductor-insulator-normal metal (SIN) junctions with the specific tunnel resistance ρ ≲ 30 Ω μm2. The junctions were fabricated from different superconducting and normal conducting materials, including Nb, Al, AuPd and Cu. The subgap leakage currents were found to be appreciably larger than those given by the standard tunnelling model. We explain our results using the model of two-electron tunnelling in the coherent diffusive transport regime. We demonstrate that even in the high-transparency SIN-junctions, a noticeable reduction of the subgap current can be achieved by splitting a junction into several submicron sub-junctions. These structures can be used as nonlinear low-noise shunts in rapid-single-flux-quantum (RSFQ) circuitry for controlling Josephson qubits.

  12. Shot noise in diffusive SNS and SIN junctions

    NASA Astrophysics Data System (ADS)

    Lefloch, Francois; Hoffmann, Christian; Quirion, David; Sanquer, Marc

    2003-05-01

    We studied shot noise in metallic SNS and doped silicon-based SIN junctions. In SNS structures, the shot noise is very much enhanced due to incoherent multiple Andreev reflections (IMAR) which are truncated, at low voltages, by inelastic electron-electron interaction. These experimental results show good agreement with recent semiclassical theory. In SIN junctions, the zero-voltage conductance is increased by disorder-induced coherent MAR (reflectionless tunneling) and we found that the shot noise is double ( SI=4 eI) below the Thouless energy and equals the full shot noise ( SI=2 eI) above. We also present conductance measurements which show the same zero bias anomaly but in a double-barrier metallic SININ junction.

  13. Paragonimiasis in Sin Ho District, Lai Chau Province, Viet Nam.

    PubMed

    Vien, C V; Phue, N C; Ha, L D; Tuan, L M; Van, N T; Pao, T C; Hoa, L T; Phoung, C T

    1997-01-01

    Forty-four cases of pulmonary paragonimiasis, two also with evidence of cerebral infection, were found in Sin Ho District in Northern Viet Nam. There were 30 males and 14 females, 2-30 years of age. The diagnosis was made by sputum examination. Pet dogs and wild dogs in the area were also found infected and the people often eat roasted crabs. PMID:9656347

  14. A New Analytic Alignment Method for a SINS.

    PubMed

    Tan, Caiming; Zhu, Xinhua; Su, Yan; Wang, Yu; Wu, Zhiqiang; Gu, Dongbing

    2015-01-01

    Analytic alignment is a type of self-alignment for a Strapdown inertial navigation system (SINS) that is based solely on two non-collinear vectors, which are the gravity and rotational velocity vectors of the Earth at a stationary base on the ground. The attitude of the SINS with respect to the Earth can be obtained directly using the TRIAD algorithm given two vector measurements. For a traditional analytic coarse alignment, all six outputs from the inertial measurement unit (IMU) are used to compute the attitude. In this study, a novel analytic alignment method called selective alignment is presented. This method uses only three outputs of the IMU and a few properties from the remaining outputs such as the sign and the approximate value to calculate the attitude. Simulations and experimental results demonstrate the validity of this method, and the precision of yaw is improved using the selective alignment method compared to the traditional analytic coarse alignment method in the vehicle experiment. The selective alignment principle provides an accurate relationship between the outputs and the attitude of the SINS relative to the Earth for a stationary base, and it is an extension of the TRIAD algorithm. The selective alignment approach has potential uses in applications such as self-alignment, fault detection, and self-calibration.

  15. A New Analytic Alignment Method for a SINS.

    PubMed

    Tan, Caiming; Zhu, Xinhua; Su, Yan; Wang, Yu; Wu, Zhiqiang; Gu, Dongbing

    2015-01-01

    Analytic alignment is a type of self-alignment for a Strapdown inertial navigation system (SINS) that is based solely on two non-collinear vectors, which are the gravity and rotational velocity vectors of the Earth at a stationary base on the ground. The attitude of the SINS with respect to the Earth can be obtained directly using the TRIAD algorithm given two vector measurements. For a traditional analytic coarse alignment, all six outputs from the inertial measurement unit (IMU) are used to compute the attitude. In this study, a novel analytic alignment method called selective alignment is presented. This method uses only three outputs of the IMU and a few properties from the remaining outputs such as the sign and the approximate value to calculate the attitude. Simulations and experimental results demonstrate the validity of this method, and the precision of yaw is improved using the selective alignment method compared to the traditional analytic coarse alignment method in the vehicle experiment. The selective alignment principle provides an accurate relationship between the outputs and the attitude of the SINS relative to the Earth for a stationary base, and it is an extension of the TRIAD algorithm. The selective alignment approach has potential uses in applications such as self-alignment, fault detection, and self-calibration. PMID:26556353

  16. A New Analytic Alignment Method for a SINS

    PubMed Central

    Tan, Caiming; Zhu, Xinhua; Su, Yan; Wang, Yu; Wu, Zhiqiang; Gu, Dongbing

    2015-01-01

    Analytic alignment is a type of self-alignment for a Strapdown inertial navigation system (SINS) that is based solely on two non-collinear vectors, which are the gravity and rotational velocity vectors of the Earth at a stationary base on the ground. The attitude of the SINS with respect to the Earth can be obtained directly using the TRIAD algorithm given two vector measurements. For a traditional analytic coarse alignment, all six outputs from the inertial measurement unit (IMU) are used to compute the attitude. In this study, a novel analytic alignment method called selective alignment is presented. This method uses only three outputs of the IMU and a few properties from the remaining outputs such as the sign and the approximate value to calculate the attitude. Simulations and experimental results demonstrate the validity of this method, and the precision of yaw is improved using the selective alignment method compared to the traditional analytic coarse alignment method in the vehicle experiment. The selective alignment principle provides an accurate relationship between the outputs and the attitude of the SINS relative to the Earth for a stationary base, and it is an extension of the TRIAD algorithm. The selective alignment approach has potential uses in applications such as self-alignment, fault detection, and self-calibration. PMID:26556353

  17. Design of a Heliostat for Centro de Investigaciones de Astronomía (CIDA)

    NASA Astrophysics Data System (ADS)

    Dávila, L. E.; Barboza, S. J.; Sánchez, G. A.; Della Prugna, F.; Cova, J.; Provenzano, S. E.; Chacón, R. D.

    2009-05-01

    This paper explains the procedure used in the design of a heliostat to be installed at the headquarters of the Centro de Investigaciones de Astronomía, located in the city of Mérida, Venezuela. The heliostat will be used mainly for educational and public outreach programs, so the design specifications did not require compensation for rotation of the Sun's image at the focal point. The engineering computational tools CAD-CAE were used in order to allow a seamless interaction between the two disciplines involved, Mechanical Engineering and Astronomy. It has also been taken into consideration, as a starting requirement, that all materials be easily available and that all parts, excluding the optics, could be manufactured with the equipment available at the CIDA workshop. These considerations were intended to reduce the cost of the device and to increase the feasibility of construction with limited technological facilities and financial resources. The results obtained by means of the computing tools used were validated through comparison against the analytical calculations. As a result, a robust but low cost heliostat was designed which in the near future will be used to project the Sun's image on a screen for public viewing and student research projects.

  18. Is n sin θ conserved along the light path?

    NASA Astrophysics Data System (ADS)

    Noorbala, Mahdiyar; Sepehrinia, Reza

    2016-03-01

    Snell’s law states that the quantity n{sin}θ is unchanged in refraction of light passing from one medium to another. We inquire whether this is true in the general case where the speed of light varies continuously within a medium. It turns out to be an instructive exercise in application of Snell’s law and Fermat’s principle. It also provides good pedagogical problems in calculus of variations to deal with the subtleties of a variable domain of integration and inclusion of constraints. The final result of these exercises is that, contrary to an initial expectation, the answer to the question in the title is negative.

  19. Structure and Organisation of SinR, the Master Regulator of Biofilm Formation in Bacillus subtilis

    PubMed Central

    Colledge, Vicki L.; Fogg, Mark J.; Levdikov, Vladimir M.; Leech, Andrew; Dodson, Eleanor J.; Wilkinson, Anthony J.

    2011-01-01

    sinR encodes a tetrameric repressor of genes required for biofilm formation in Bacillus subtilis. sinI, which is transcribed under Spo0A control, encodes a dimeric protein that binds to SinR to form a SinR–SinI heterodimer in which the DNA-binding functions of SinR are abrogated and repression of biofilm genes is relieved. The heterodimer-forming surface comprises residues conserved between SinR and SinI. Each forms a pair of α-helices that hook together to form an intermolecular four-helix bundle. Here, we are interested in the assembly of the SinR tetramer and its binding to DNA. Size-exclusion chromatography with multi-angle laser light scattering and crystallographic analysis reveal that a DNA-binding fragment of SinR (residues 1–69) is a monomer, while a SinI-binding fragment (residues 74–111) is a tetramer arranged as a dimer of dimers. The SinR(74–111) chain forms two α-helices with the organisation of the dimer similar to that observed in the SinR–SinI complex. The tetramer is formed through interactions of residues at the C-termini of the four chains. A model of the intact SinR tetramer in which the DNA binding domains surround the tetramerisation core was built. Fluorescence anisotropy and surface plasmon resonance experiments showed that SinR binds to an oligonucleotide duplex, 5′-TTTGTTCTCTAAAGAGAACTTA-3′, containing a pair of SinR consensus sequences in inverted orientation with a Kd of 300 nM. The implications of these data for promoter binding and the curious quaternary structural transitions of SinR upon binding to (i) SinI and (ii) the SinR-like protein SlrR, which “repurposes” SinR as a repressor of autolysin and motility genes, are discussed. PMID:21708175

  20. Measurement of the cp violation parameter sin 2 beta

    SciTech Connect

    K.F. Kelley

    1999-01-26

    This thesis presents a measurement of the time-dependent asymmetry in the rate of {anti B}{sub d}{sup 0} versus B{sub d}{sup 0} decays to J/{psi}K{sub s}{sup 0}. In the context of the Standard Model this is interpreted as a measurement of the CP violation parameter sin(2{beta}). A total of 198{+-}17 B{sub d}{sup 0}/{anti B}{sub d}{sup 0} decays were observed in p{anti p} collisions at {radical}s=1.8 TeV by the CDF detector at the Fermilab Tevatron. The initial B flavor (whether B{sup 0} or {anti B}{sup 0}) is determined by a same-side flavor tagging technique. The analysis results in sin(2{beta})=1.8{+-}1.1(stat.){+-}0.3(syst.). This analysis demonstrates the feasibility of studying CP violation in the B{sup 0}-{anti B}{sup 0} system at a hadron collider. By applying the methods used in this analysis, future, higher-statistics experiments should be able to tightly constrain the parameters of the Standard Model.

  1. Instantaneous Observability of Tightly Coupled SINS/GPS during Maneuvers.

    PubMed

    Jiang, Junxiang; Yu, Fei; Lan, Haiyu; Dong, Qianhui

    2016-01-01

    The tightly coupled strapdown inertial navigation system (SINS)/global position system (GPS) has been widely used. The system observability determines whether the system state can be estimated by a filter efficiently or not. In this paper, the observability analysis of a two-channel and a three-channel tightly coupled SINS/GPS are performed, respectively, during arbitrary translational maneuvers and angle maneuvers, where the translational maneuver and angle maneuver are modeled. A novel instantaneous observability matrix (IOM) based on a reconstructed psi-angle model is proposed to make the theoretical analysis simpler, which starts from the observability definition directly. Based on the IOM, a series of theoretical analysis are performed. Analysis results show that almost all kinds of translational maneuver and angle maneuver can make a three-channel system instantaneously observable, but there is no one translational maneuver or angle maneuver can make a two-channel system instantaneously observable. The system's performance is investigated when the system is not instantaneously observable. A series of simulation studies based on EKF are performed to confirm the analytic conclusions. PMID:27240369

  2. SInCRe-structural interactome computational resource for Mycobacterium tuberculosis.

    PubMed

    Metri, Rahul; Hariharaputran, Sridhar; Ramakrishnan, Gayatri; Anand, Praveen; Raghavender, Upadhyayula S; Ochoa-Montaño, Bernardo; Higueruelo, Alicia P; Sowdhamini, Ramanathan; Chandra, Nagasuma R; Blundell, Tom L; Srinivasan, Narayanaswamy

    2015-01-01

    We have developed an integrated database for Mycobacterium tuberculosis H37Rv (Mtb) that collates information on protein sequences, domain assignments, functional annotation and 3D structural information along with protein-protein and protein-small molecule interactions. SInCRe (Structural Interactome Computational Resource) is developed out of CamBan (Cambridge and Bangalore) collaboration. The motivation for development of this database is to provide an integrated platform to allow easily access and interpretation of data and results obtained by all the groups in CamBan in the field of Mtb informatics. In-house algorithms and databases developed independently by various academic groups in CamBan are used to generate Mtb-specific datasets and are integrated in this database to provide a structural dimension to studies on tuberculosis. The SInCRe database readily provides information on identification of functional domains, genome-scale modelling of structures of Mtb proteins and characterization of the small-molecule binding sites within Mtb. The resource also provides structure-based function annotation, information on small-molecule binders including FDA (Food and Drug Administration)-approved drugs, protein-protein interactions (PPIs) and natural compounds that bind to pathogen proteins potentially and result in weakening or elimination of host-pathogen protein-protein interactions. Together they provide prerequisites for identification of off-target binding. PMID:26130660

  3. SInCRe—structural interactome computational resource for Mycobacterium tuberculosis

    PubMed Central

    Metri, Rahul; Hariharaputran, Sridhar; Ramakrishnan, Gayatri; Anand, Praveen; Raghavender, Upadhyayula S.; Ochoa-Montaño, Bernardo; Higueruelo, Alicia P.; Sowdhamini, Ramanathan; Chandra, Nagasuma R.; Blundell, Tom L.; Srinivasan, Narayanaswamy

    2015-01-01

    We have developed an integrated database for Mycobacterium tuberculosis H37Rv (Mtb) that collates information on protein sequences, domain assignments, functional annotation and 3D structural information along with protein–protein and protein–small molecule interactions. SInCRe (Structural Interactome Computational Resource) is developed out of CamBan (Cambridge and Bangalore) collaboration. The motivation for development of this database is to provide an integrated platform to allow easily access and interpretation of data and results obtained by all the groups in CamBan in the field of Mtb informatics. In-house algorithms and databases developed independently by various academic groups in CamBan are used to generate Mtb-specific datasets and are integrated in this database to provide a structural dimension to studies on tuberculosis. The SInCRe database readily provides information on identification of functional domains, genome-scale modelling of structures of Mtb proteins and characterization of the small-molecule binding sites within Mtb. The resource also provides structure-based function annotation, information on small-molecule binders including FDA (Food and Drug Administration)-approved drugs, protein–protein interactions (PPIs) and natural compounds that bind to pathogen proteins potentially and result in weakening or elimination of host–pathogen protein–protein interactions. Together they provide prerequisites for identification of off-target binding. Database URL: http://proline.biochem.iisc.ernet.in/sincre PMID:26130660

  4. Instantaneous Observability of Tightly Coupled SINS/GPS during Maneuvers

    PubMed Central

    Jiang, Junxiang; Yu, Fei; Lan, Haiyu; Dong, Qianhui

    2016-01-01

    The tightly coupled strapdown inertial navigation system (SINS)/global position system (GPS) has been widely used. The system observability determines whether the system state can be estimated by a filter efficiently or not. In this paper, the observability analysis of a two-channel and a three-channel tightly coupled SINS/GPS are performed, respectively, during arbitrary translational maneuvers and angle maneuvers, where the translational maneuver and angle maneuver are modeled. A novel instantaneous observability matrix (IOM) based on a reconstructed psi-angle model is proposed to make the theoretical analysis simpler, which starts from the observability definition directly. Based on the IOM, a series of theoretical analysis are performed. Analysis results show that almost all kinds of translational maneuver and angle maneuver can make a three-channel system instantaneously observable, but there is no one translational maneuver or angle maneuver can make a two-channel system instantaneously observable. The system’s performance is investigated when the system is not instantaneously observable. A series of simulation studies based on EKF are performed to confirm the analytic conclusions. PMID:27240369

  5. Sinning against nature: the theory of background conditions.

    PubMed

    Blackford, R

    2006-11-01

    Debates about the moral and political acceptability of particular sexual practices and new technologies often include appeals to a supposed imperative to follow nature. If nature is understood as the totality of all phenomena or as those things that are not artificial, there is little prospect of developing a successful argument to impugn interference with it or sinning against it. At the same time, there are serious difficulties with approaches that seek to identify "proper" human functioning. An alternative approach is to understand interference with nature as acting in a manner that threatens basic background conditions to human choice. Arguably, the theory of background conditions helps explain much of the hostility to practices and technologies that allegedly sin against nature. The theory does not, however, entail that appeals to nature are relevant or rational. Such appeals should be subjected to sceptical scrutiny. Indeed, the theory suggests that arguments against practices and technologies that can be seen as contrary to nature sometimes exercise a psychological attraction that is disproportional to their actual cogency.

  6. SiN etching characteristics of Ar/CH3F/O2 plasma and dependence on SiN film density

    NASA Astrophysics Data System (ADS)

    Ohtake, Hiroto; Wanifuchi, Tomiko; Sasaki, Masaru

    2016-08-01

    We evaluated the silicon nitride (SiN) etching characteristics of Ar/O2/hydrofluorocarbon plasma. Ar/CH3F/O2 plasma achieved a high etching selectivity of SiN to SiO2 by increasing the oxygen flow rate. We also evaluated the dependence of SiN etching characteristics on SiN film density. A low-density film deposited at a low temperature of 200 °C (by plasma-enhanced CVD, PECVD) showed an 8–20% lower etching rate of SiN than a high-density film deposited at a high temperature of 780 °C (by low-pressure CVD, LPCVD) when we had a low RF bias of 30 W. This PECVD film might move the competitive balance to oxidation from fluorination, reducing the SiN etching rate. However, when we have a high RF bias of more than 50 W, the SiN etching rate is 2–15% higher in the PECVD film than in the LPCVD film. The etching rate of SiN at various densities depends on the balance between oxidation and ion bombardment.

  7. An array of SIN tunnel junctions as a sensitive thermometer

    NASA Astrophysics Data System (ADS)

    Agulo, I. J.; Kuzmin, L.

    2008-01-01

    We have fabricated and measured an array of superconductor-insulator-normal metal (SIN) tunnel junctions for the purpose of using it as a sensitive thermometer. An increase in the temperature responsivity of dV/dT~5 µV mK-1 for ten junctions is observed from dV/dT~1 µV mK-1 for a single junction. We then used such an array thermometer to measure the temperature stability of the Heliox AC-V cryogen-free refrigerator. We have been able to measure a temperature stability of ± 250 µK over a period of 8 h with a temperature resolution of ± 100 µK.

  8. Overview of some biomedical research projects in tropical medicine conducted at the Instituto Venezolano de Investigaciones Cientificas.

    PubMed

    Romano, E; Cesari, I; Escalante, A; Liprandi, F; O'Daly, J A; Perez, H; Takiff, H

    2000-01-01

    The Instituto Venezolano de Investigaciones Cientificas (IVIC) is a government-funded multidisciplinary academic institution dedicated to research, development and technology in many areas of knowledge. Biomedical projects and publications comprise about 40% of the total at IVIC. In this article, we present an overview of some selected research and development projects conducted at IVIC which we believe contain new and important aspects related to malaria, ancylostomiasis, dengue fever, leishmaniasis and tuberculosis. Other projects considered of interest in the general area of tropical medicine are briefly described. This article was prepared as a small contribution to honor and commemorate the centenary of the Instituto Oswaldo Cruz.

  9. Optimization of electron cooling by SIN tunnel junctions

    NASA Astrophysics Data System (ADS)

    Kuzmin, L.; Agulo, I.; Fominsky, M.; Savin, A.; Tarasov, M.

    2004-05-01

    We report on the optimization of electron cooling by SIN tunnel junctions due to the advanced geometry of superconducting electrodes and very effective normal metal traps for more efficient removal of quasiparticles at temperatures from 25 to 500 mK. The maximum decrease in electron temperature of about 200 mK has been observed at bath temperatures 300-350 mK. We used four-junction geometry with Al-AlOx-Cr/Cu tunnel junctions and Au traps. Efficient electron cooling was realized due to the improved geometry of the cooling tunnel junctions (quadrant shape of the superconducting electrode) and optimized Au traps just near the junctions ({\\approx }0.5~\\micmu {\\mathrm {m}} ) to reduce reabsorption of quasiparticles after removing them from normal metal. The maximum cooling effect was increased from a temperature drop of d T = -56 mK (ordinary cross geometry) to -130 mK (improved geometry of superconducting electrodes) and to d T = -200 mK (improved geometry of superconducting electrodes and effective Au traps). The heating peak (instead of cooling) near the zero voltage across cooling junctions has been observed in practice for all samples at temperatures below 150 mK. For higher cooling voltages close to the superconducting gap, the heating was converted to cooling with decreased amplitude. The leakage resistance of the tunnel junctions gives a reasonable explanation of the heating peak. The phonon reabsorption due to the recombination of quasiparticles in superconducting electrodes gives an additional improvement in the theoretical fitting but could not explain the heating peak. An anomalous zero-bias resistance peak has been observed for all tested structures. The peak is explained by Coulomb blockade of tunnelling in transistor-type structures with relatively small tunnel junctions. The work on electron cooling is devoted to the development of a cold-electron bolometer (CEB) with capacitive coupling by SIN tunnel junctions to the antenna for sensitive detection

  10. Identification of Genetic Suppressors of the Sin3A Knockdown Wing Phenotype

    PubMed Central

    Fox, Stephanie; Gammouh, Sarah; Pile, Lori A.

    2012-01-01

    The role of the Sin3A transcriptional corepressor in regulating the cell cycle is established in various metazoans. Little is known, however, about the signaling pathways that trigger or are triggered by Sin3A function. To discover genes that work in similar or opposing pathways to Sin3A during development, we have performed an unbiased screen of deficiencies of the Drosophila third chromosome. Additionally, we have performed a targeted loss of function screen to identify cell cycle genes that genetically interact with Sin3A. We have identified genes that encode proteins involved in regulation of gene expression, signaling pathways and cell cycle that can suppress the curved wing phenotype caused by the knockdown of Sin3A. These data indicate that Sin3A function is quite diverse and impacts a wide variety of cellular processes. PMID:23166712

  11. Illness, disease and sin: the connection between genetics and spirituality.

    PubMed

    Beck, Matthias

    2007-01-01

    The New Testament, while rejecting any superficial connection between illness and sin, does not reject a possible connection between illness and a person's relationship with God. An example can be seen in the story of the young blind man who was healed (St. John 9:3). His blindness does not result from any fault he or his parents had committed but apparently from God's wish to reveal his own healing power. The inner blindness of the Pharisees is a different type of blindness far more difficult to heal. The blind young man was actually healed, not only in body but also in soul. Such miraculous healings are rare nowadays. However, if one takes a closer look at modern genetics and psycho-neuro-immunological findings, one may come to a better understanding of how miracle healings are linked to man's inner life and therefore also to his religiousness. Many diseases have genetic backgrounds. Defective genes, however, do not necessarily lead to subsequent illness. Genes have to be switched on or off. Only activated genes trigger pathological change. The human brain and all of man's thinking and feeling are intimately connected with such activations. We may thus conclude that both inner life and religious outlook on life are relevant to the origin and development of diseases.

  12. Natural history of Sin Nombre virus in western Colorado.

    PubMed Central

    Calisher, C. H.; Sweeney, W.; Mills, J. N.; Beaty, B. J.

    1999-01-01

    A mark-recapture longitudinal study of immunoglobulin G (IgG) antibody to Sin Nombre virus (SNV) in rodent populations in western Colorado (1994-results summarized to October 1997) indicates the presence of SNV or a closely related hantavirus at two sites. Most rodents (principally deer mice, Peromyscus maniculatus, and pinyon mice, P. truei) did not persist on the trapping webs much beyond 1 month after first capture. Some persisted more than 1 year, which suggests that even a few infected deer mice could serve as transseasonal reservoirs and mechanisms for over-winter virus maintenance. A positive association between wounds and SNV antibody in adult animals at both sites suggests that when infected rodents in certain populations fight with uninfected rodents, virus amplification occurs. At both sites, male rodents comprised a larger percentage of seropositive mice than recaptured mice, which suggests that male mice contribute more to the SNV epizootic cycle than female mice. In deer mice, IgG antibody prevalence fluctuations were positively associated with population fluctuations. The rates of seroconversion, which in deer mice at both sites occurred mostly during late summer and midwinter, were higher than the seroprevalence, which suggests that the longer deer mice live, the greater the probability they will become infected with SNV. PMID:10081680

  13. Regulation of His4 Expression by the Saccharomyces Cerevisiae Sin4 Transcriptional Regulator

    PubMed Central

    Jiang, Y. W.; Stillman, D. J.

    1995-01-01

    The yeast SIN4 gene functions in the transcriptional activation and repression of diverse yeast genes. Previous experiments suggest a sin4 mutation affects chromatin structure and thus alters transcriptional regulation. In this report we show that SIN4 is required for full expression of the HIS4, Ty1, and MATα genes, in addition to the previously described SIN4-dependence of CTS1 expression. All of these genes contain within their promoters a binding site for the Rap1p transcriptional regulator. However, SIN4 does not play a direct role either in transcriptional activation or repression by Rap1p. The HIS4 gene can be activated by either of two pathways, the basal or the inducible pathway, and experiments are described that show that a sin4 mutation affects both pathways. It was shown previously that mutation of the Rap1p binding site in the HIS4 promoter causes a similar effect on HIS4 expression and that this promoter mutation also causes a change in chromatin structure. The SNF2/SWI2 gene is also required for full HIS4 expression, and we show that a sin4 snf2 double mutant is not synergistic compared to either single mutant. We show that nucleosomes are positioned at the HIS4 promoter and that this positioning is disrupted in a snf2 mutant but not in a sin4 mutant. These findings suggest that SIN4 plays a distinct role in transcriptional regulation. PMID:7635278

  14. A new method based on WMRA and ANN for GPS/SINS integration for aerocraft navigation

    NASA Astrophysics Data System (ADS)

    Zhu, Xuefen; Chen, Xiyuan; Li, Zigang

    2006-11-01

    Global Positioning System (GPS) can provide precise positioning information to an unlimited number of users anywhere on the earth. However, the defect cannot be neglected, because there exists one blind district when the aerocraft flying through some altitude space. During the short time in the blind district, all radio signals can't be attained including the GPS signals. An integrated GPS/SINS (Strapdown Inertial Navigation System) Navigation system is presented in this paper. The SINS based on numerical computing platform has many advantages such as high reliability, small bulk and low cost ect. The integration of GPS and SINS, therefore, provides a navigation system that has superior performance in comparison with either a GPS or a SINS stand-alone system. This paper presents a new model-less algorithm that can perform the self-following of the aerocraft under all conditions. For improving the precision of the hybrid GPS/SINS navigation system, fusing data from a SINS and GPS hardware utilizes wavelet multi-resolution analysis (WMRA) and Radial Basis Function (RBF) Artificial Neural Networks (ANN). The WMRA is used to compare the SINS and GPS position outputs at different resolution levels. These differences represent, in general, the SINS errors, which are used to correct for the SINS outputs during GPS outages. The RBF-ANN model is then trained to predict the SINS position errors in real time and provide accurate positioning of the moving aerocraft. The simulations show that good results in SINS/GPS positioning accuracy can be obtained by applying the WMRA and RBF-ANN methods.

  15. Original antigenic sin with human bocaviruses 1-4.

    PubMed

    Li, Xuemeng; Kantola, Kalle; Hedman, Lea; Arku, Benedict; Hedman, Klaus; Söderlund-Venermo, Maria

    2015-10-01

    Human bocavirus (HBoV) 1 is a widespread parvovirus causing acute respiratory disease in young children. In contrast, HBoV2 occurs in the gastrointestinal tract and is potentially associated with gastroenteritis, whilst HBoV3 and -4 infections are less frequent and have not yet been linked with human disease. Due to HBoV1 DNA persistence in the nasopharynx, serology has been advocated as a better alternative for diagnosing acute infections. In constitutionally healthy children, we previously noted that pre-existing HBoV2 immunity in a subsequent HBoV1 infection typically resulted in low or non-existent HBoV1-specific antibody responses. A phenomenon describing such immunological events among related viruses has been known since the 1950s as 'original antigenic sin' (OAS). The aim of this study was to characterize this putative OAS phenomenon in a more controlled setting. Follow-up sera of 10 rabbit pairs, inoculated twice with HBoV1-4 virus-like particles (VLPs) or control antigens, in various combinations, were analysed with HBoV1-4 IgG enzyme immunoassays with and without depletion of heterotypic HBoV antibodies. There were no significant IgG boosts after the second inoculation in either the heterologously or the homologously HBoV-inoculated rabbits, but a clear increase in cross-reactivity was seen with time. We could, however, distinguish a distinct OAS pattern from plain cross-reactivity: half of the heterologously inoculated rabbits showed IgG patterns representative of the OAS hypothesis, in line with our prior results with naturally infected children. HBoVs are the first parvoviruses to show the possible existence of OAS. Our findings provide new information on HBoV1-4 immunity and emphasize the complexity of human bocavirus diagnosis. PMID:26224569

  16. SIN3 is critical for stress resistance and modulates adult lifespan

    PubMed Central

    Barnes, Valerie L.; Bhat, Abhineeth; Unnikrishnan, Archana; Heydari, Ahmad R.; Arking, Robert; Pile, Lori A.

    2014-01-01

    Coordinate control of gene activity is critical for fitness and longevity of an organism. The SIN3 histone deacetylase (HDAC) complex functions as a transcriptional repressor of many genes. SIN3-regulated genes include those that encode proteins affecting multiple aspects of mitochondrial function, such as energy production and stress responsiveness, important for health maintenance. Here we used Drosophila melanogaster as a model organism to examine the role of SIN3 in the regulation of fitness and longevity. Adult flies with RNA interference (RNAi) induced knockdown expression of Sin3A have reduced climbing ability; an activity that likely requires fully functional mitochondria. Additionally, compared to wild type, adult Sin3A knockdown flies were more sensitive to oxidative stress. Interestingly, media supplementation with the antioxidant glutathione largely restored fly tolerance to oxidative stress. Although Sin3A knockdown flies exhibited decreased longevity compared to wild type, no significant changes in expression of many well-categorized aging genes were observed. We found, however, that Sin3A knockdown corresponded to a significant reduction in expression of genes encoding proteins involved in the de novo synthesis of glutathione. Taken together, the data support a model whereby SIN3 regulates a gene expression program required for proper mitochondrial function and effective stress response during adulthood. PMID:25133314

  17. [Instituto de Investigaciones Clinicas "Dr. Américo Negrette": 55 years of excellent research versus global economic recession].

    PubMed

    Valero Cedeño, Nereida Josefina

    2014-12-01

    The Instituto de Investigaciones Clínicas "Dr. Américo Negrette" belongs to the Faculty of Medicine at University of Zulia in Maracaibo, Zulia State, Venezuela. It was created on December 4, 1959 by Dr. Américo Negrette. Today, with 55 years of existence, the Institute seeks to fulfill the mission that characterizes it, based on the values instilled by its founder and maintained by subsequent generations, whose research projects are implemented through seven research sections: Biochemistry, Hematologic Research, Neuropharmacology and Neuroscience, Immunology and Cell Biology, Clinical Neurochemistry, Parasitology and Virology. The research originated in these laboratories have become national and international points of reference, despite the current economic situation with budget deficits that put at risk the quality and originality of their projects with negative consequences on the productivity and applications for health population, reasons of biomedical research.

  18. Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe.

    PubMed

    Krapp, Andrea; Simanis, Viesturs

    2014-07-15

    The Schizosaccharomyces pombe septation initiation network (SIN) is required for cytokinesis during vegetative growth and for spore formation during meiosis. Regulation of the SIN during mitosis has been studied extensively, but less is known about its meiotic regulation. Here, we show that several aspects of SIN regulation differ between mitosis and meiosis. First, the presence of GTP-bound Spg1p is not the main determinant of the timing of Cdc7p and Sid1p association with the spindle pole body (SPB) during meiosis. Second, the localisation dependencies of SIN proteins differ from those in mitotic cells, suggesting a modified functional organisation of the SIN during meiosis. Third, there is stage-specific degradation of SIN components in meiosis; Byr4p is degraded after meiosis I, whereas the degradation of Cdc7p, Cdc11p and Sid4p occurs after the second meiotic division and depends upon the ubiquitin ligase Dma1p. Finally, Dma1p-dependent degradation is not restricted to the SIN, as we show that Dma1p is needed for the degradation of Mcp6p (also known as Hrs1p) during meiosis I. Taken together, these data suggest that stage-specific targeted proteolysis plays an important role in regulating meiotic progression.

  19. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia

    PubMed Central

    Gallagher, Shannon J.; Kofman, Amber E.; Huszar, Jessica M.; Dannenberg, Jan-Hermen; DePinho, Ronald A.; Braun, Robert E.; Payne, Christopher J.

    2012-01-01

    Chromatin modifier Swi-independent 3a (SIN3A), together with associated histone deacetylases, influences gene expression during development and differentiation through a variety of transcription factors in a cell-specific manner. Sin3a is essential for the maintenance of inner cell mass cells of mouse blastocysts, embryonic fibroblasts, and myoblasts, but is not required for the survival of trophectoderm or Sertoli cells. To better understand how this transcriptional regulator modulates cells at different developmental stages within a single lineage, we used conditional gene targeting in mice to ablate Sin3a from perinatal quiescent male gonocytes and from postnatal differentiating spermatogonia. Mitotic germ cells expressing stimulated by retinoic acid gene 8 (Stra8) that lacked Sin3a exhibited increased DNA damage and apoptosis, yet collectively progressed through meiosis and spermiogenesis and generated epididymal sperm at approximately 50% of control levels, sufficient for normal fertility. In contrast, perinatal gonocytes lacking Sin3a underwent rapid depletion that coincided with cell cycle reentry, exhibiting 2.5-fold increased histone H3 phosphorylation upon cycling that suggested a prophase/metaphase block; germ cells were almost entirely absent two weeks after birth, resulting in sterility. Gene expression profiling of neonatal testes containing Sin3a-deleted gonocytes identified upregulated transcripts highly associated with developmental processes and pattern formation, and downregulated transcripts involved in nuclear receptor activity, including Nr4a1 (Nur77). Interestingly, Nr4a1 levels were elevated in testes containing Stra8-expressing, Sin3a-deleted spermatogonia. SIN3A directly binds to the Nr4a1 promoter, and Nr4a1 expression is diminished upon spermatogonial differentiation in vitro. We conclude that within the male germline, Sin3a is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating

  20. Ceramic Technology Project database: September 1990 summary report. [SiC, SiN, whisker-reinforced SiN, ZrO-toughened aluminas, zirconias, joints

    SciTech Connect

    Keyes, B.L.P.

    1992-06-01

    Data generated within the Ceramic Technology Project (CTP) represent a valuable resource for both research and industry. The CTP database was created to provide easy access to this information in electronic and hardcopy forms by using a computerized database and by issuing periodic hardcopy reports on the database contents. This report is the sixth in a series of semiannual database summaries and covers recent additions to the database, including joined brazed specimen test data. It covers 1 SiC, 34 SiN, 10 whisker-reinforced SiN, 2 zirconia-toughened aluminas, 8 zirconias, and 34 joints.

  1. Integrated Positioning for Coal Mining Machinery in Enclosed Underground Mine Based on SINS/WSN

    PubMed Central

    Hui, Jing; Wu, Lei; Yan, Wenxu; Zhou, Lijuan

    2014-01-01

    To realize dynamic positioning of the shearer, a new method based on SINS/WSN is studied in this paper. Firstly, the shearer movement model is built and running regularity of the shearer in coal mining face has been mastered. Secondly, as external calibration of SINS using GPS is infeasible in enclosed underground mine, WSN positioning strategy is proposed to eliminate accumulative error produced by SINS; then the corresponding coupling model is established. Finally, positioning performance is analyzed by simulation and experiment. Results show that attitude angle and position of the shearer can be real-timely tracked by integrated positioning strategy based on SINS/WSN, and positioning precision meet the demand of actual working condition. PMID:24574891

  2. Integrated positioning for coal mining machinery in enclosed underground mine based on SINS/WSN.

    PubMed

    Fan, Qigao; Li, Wei; Hui, Jing; Wu, Lei; Yu, Zhenzhong; Yan, Wenxu; Zhou, Lijuan

    2014-01-01

    To realize dynamic positioning of the shearer, a new method based on SINS/WSN is studied in this paper. Firstly, the shearer movement model is built and running regularity of the shearer in coal mining face has been mastered. Secondly, as external calibration of SINS using GPS is infeasible in enclosed underground mine, WSN positioning strategy is proposed to eliminate accumulative error produced by SINS; then the corresponding coupling model is established. Finally, positioning performance is analyzed by simulation and experiment. Results show that attitude angle and position of the shearer can be real-timely tracked by integrated positioning strategy based on SINS/WSN, and positioning precision meet the demand of actual working condition.

  3. People Who Have Committed a Certain Sin Ought to Be Dead

    ERIC Educational Resources Information Center

    Leenaars, Antoon A.

    2006-01-01

    People who have committed a certain sin ought to be dead; I am a person who has committed that sin; therefore, I ought to be dead. Thus is the logic of a suicidal mind. Lester, Szaz, and others argue the "sinner" should always be allowed to kill him/herself. Shneidman, Leenaars and others do not agree. Once one knows the suicidal mind, it is easy…

  4. Sin(x)**2 + cos(x)**2 = 1. [programming identities using comparative combinatorial substitutions

    NASA Technical Reports Server (NTRS)

    Stoutemyer, D. R.

    1977-01-01

    Attempts to achieve tasteful automatic employment of the identities sin sq x + cos sq x = 1 and cos sq h x -sin sq h x = 1 in a manner which truly minimizes the complexity of the resulting expression are described. The disappointments of trigonometric reduction, trigonometric expansion, pattern matching, Poisson series, and Demoivre's theorem are related. The advantages of using the method of comparative combinatorial substitutions are illustrated.

  5. Wide bandwidth SIN tunnel junction thermometers for mesoscopic calorimetry and bolometry

    NASA Astrophysics Data System (ADS)

    Schmidt, D. R.; Yung, C. S.; Cleland, A. N.

    2003-03-01

    Thermodynamic measurements of mesoscopic devices require sensitive thermometers which are small enough to allow integration with nanostructures. Superconductor-insulator-normal metal (SIN) tunnel junctions meet these stringent requirements. We have achieved high bandwidth ( ˜10 MHz) readout of the inherently resistive SIN thermometer by embedding the junction in an LC resonator (f_res ˜ 350 MHz). We will discuss our implementation of this new technology and the implications for radio-frequency calorimetry of mesocopic devices and bolometetry.

  6. Opposite side jet charge tagging and measurement of CP asymmetry parameter $\\sin_{2\\beta}$ at D0

    SciTech Connect

    Zhang, Xiaojian

    2004-01-01

    This dissertation describes the first CP asymmetry parameter sin(2β) measurement by the DO collaboration, sing the opposite side jet charge tagging algorithm in determining B-flavor. The time integrated measurement yields sin(2β) = 0.82 ± 1.80, and the time dependent measurement gives sin(2β) = 1.80 ± 1.15.

  7. AUV Positioning Method Based on Tightly Coupled SINS/LBL for Underwater Acoustic Multipath Propagation

    PubMed Central

    Zhang, Tao; Shi, Hongfei; Chen, Liping; Li, Yao; Tong, Jinwu

    2016-01-01

    This paper researches an AUV (Autonomous Underwater Vehicle) positioning method based on SINS (Strapdown Inertial Navigation System)/LBL (Long Base Line) tightly coupled algorithm. This algorithm mainly includes SINS-assisted searching method of optimum slant-range of underwater acoustic propagation multipath, SINS/LBL tightly coupled model and multi-sensor information fusion algorithm. Fuzzy correlation peak problem of underwater LBL acoustic propagation multipath could be solved based on SINS positional information, thus improving LBL positional accuracy. Moreover, introduction of SINS-centered LBL locating information could compensate accumulative AUV position error effectively and regularly. Compared to loosely coupled algorithm, this tightly coupled algorithm can still provide accurate location information when there are fewer than four available hydrophones (or within the signal receiving range). Therefore, effective positional calibration area of tightly coupled system based on LBL array is wider and has higher reliability and fault tolerance than loosely coupled. It is more applicable to AUV positioning based on SINS/LBL. PMID:26978361

  8. AUV Positioning Method Based on Tightly Coupled SINS/LBL for Underwater Acoustic Multipath Propagation.

    PubMed

    Zhang, Tao; Shi, Hongfei; Chen, Liping; Li, Yao; Tong, Jinwu

    2016-03-11

    This paper researches an AUV (Autonomous Underwater Vehicle) positioning method based on SINS (Strapdown Inertial Navigation System)/LBL (Long Base Line) tightly coupled algorithm. This algorithm mainly includes SINS-assisted searching method of optimum slant-range of underwater acoustic propagation multipath, SINS/LBL tightly coupled model and multi-sensor information fusion algorithm. Fuzzy correlation peak problem of underwater LBL acoustic propagation multipath could be solved based on SINS positional information, thus improving LBL positional accuracy. Moreover, introduction of SINS-centered LBL locating information could compensate accumulative AUV position error effectively and regularly. Compared to loosely coupled algorithm, this tightly coupled algorithm can still provide accurate location information when there are fewer than four available hydrophones (or within the signal receiving range). Therefore, effective positional calibration area of tightly coupled system based on LBL array is wider and has higher reliability and fault tolerance than loosely coupled. It is more applicable to AUV positioning based on SINS/LBL.

  9. Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation

    PubMed Central

    Liaw, Gwo-Jen

    2016-01-01

    Histone deacetylation plays an important role in transcriptional repression. Previous results showed that the genetic interaction between ttk and rpd3, which encodes a class I histone deacetylase, is required for tll repression. This study investigated the molecular mechanism by which Ttk69 recruits Rpd3. Using yeast two-hybrid screening and datamining, one novel protein was found that weakly interacts with Ttk69 and Sin3A, designated as Protein interacting with Ttk69 and Sin3A (Pits). Pits protein expressed in the early stages of embryos and bound to the region of the tor response element in vivo. Expanded tll expression patterns were observed in embryos lacking maternal pits activity and the expansion was not widened by reducing either maternal ttk or sin3A activity. However, in embryos with simultaneously reduced maternal pits and sin3A activities or maternal pits, sin3A and ttk activities, the proportions of the embryos with expanded tll expression were significantly increased. These results indicate that all three gene activities are involved in tll repression. Level of histone H3 acetylation in the tll proximal region was found to be elevated in embryo with reduced these three gene activities. In conclusion, Ttk69 causes the histone deacetylation-mediated repression of tll via the interaction of Pits and Sin3A. PMID:27622813

  10. AUV Positioning Method Based on Tightly Coupled SINS/LBL for Underwater Acoustic Multipath Propagation.

    PubMed

    Zhang, Tao; Shi, Hongfei; Chen, Liping; Li, Yao; Tong, Jinwu

    2016-01-01

    This paper researches an AUV (Autonomous Underwater Vehicle) positioning method based on SINS (Strapdown Inertial Navigation System)/LBL (Long Base Line) tightly coupled algorithm. This algorithm mainly includes SINS-assisted searching method of optimum slant-range of underwater acoustic propagation multipath, SINS/LBL tightly coupled model and multi-sensor information fusion algorithm. Fuzzy correlation peak problem of underwater LBL acoustic propagation multipath could be solved based on SINS positional information, thus improving LBL positional accuracy. Moreover, introduction of SINS-centered LBL locating information could compensate accumulative AUV position error effectively and regularly. Compared to loosely coupled algorithm, this tightly coupled algorithm can still provide accurate location information when there are fewer than four available hydrophones (or within the signal receiving range). Therefore, effective positional calibration area of tightly coupled system based on LBL array is wider and has higher reliability and fault tolerance than loosely coupled. It is more applicable to AUV positioning based on SINS/LBL. PMID:26978361

  11. Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation.

    PubMed

    Liaw, Gwo-Jen

    2016-01-01

    Histone deacetylation plays an important role in transcriptional repression. Previous results showed that the genetic interaction between ttk and rpd3, which encodes a class I histone deacetylase, is required for tll repression. This study investigated the molecular mechanism by which Ttk69 recruits Rpd3. Using yeast two-hybrid screening and datamining, one novel protein was found that weakly interacts with Ttk69 and Sin3A, designated as Protein interacting with Ttk69 and Sin3A (Pits). Pits protein expressed in the early stages of embryos and bound to the region of the tor response element in vivo. Expanded tll expression patterns were observed in embryos lacking maternal pits activity and the expansion was not widened by reducing either maternal ttk or sin3A activity. However, in embryos with simultaneously reduced maternal pits and sin3A activities or maternal pits, sin3A and ttk activities, the proportions of the embryos with expanded tll expression were significantly increased. These results indicate that all three gene activities are involved in tll repression. Level of histone H3 acetylation in the tll proximal region was found to be elevated in embryo with reduced these three gene activities. In conclusion, Ttk69 causes the histone deacetylation-mediated repression of tll via the interaction of Pits and Sin3A. PMID:27622813

  12. sinI- and expR-dependent quorum sensing in Sinorhizobium meliloti.

    PubMed

    Gao, Mengsheng; Chen, Hancai; Eberhard, Anatol; Gronquist, Matthew R; Robinson, Jayne B; Rolfe, Barry G; Bauer, Wolfgang D

    2005-12-01

    Quorum sensing (QS) in Sinorhizobium meliloti, the N-fixing bacterial symbiont of Medicago host plants, involves at least half a dozen different N-acyl homoserine lactone (AHL) signals and perhaps an equal number of AHL receptors. The accumulation of 55 proteins was found to be dependent on SinI, the AHL synthase, and/or on ExpR, one of the AHL receptors. Gas chromatography-mass spectrometry and electrospray ionization tandem mass spectrometry identified 3-oxo-C(14)-homoserine lactone (3-oxo-C(14)-HSL), C(16)-HSL, 3-oxo-C(16)-HSL, C(16:1)-HSL, and 3-oxo-C(16:1)-HSL as the sinI-dependent AHL QS signals accumulated by the 8530 expR(+) strain under the conditions used for proteome analysis. The 8530 expR(+) strain secretes additional, unidentified QS-active compounds. Addition of 200 nM C(14)-HSL or C(16:1)-HSL, two of the known SinI AHLs, affected the levels of 75% of the proteins, confirming that their accumulation is QS regulated. A number of the QS-regulated proteins have functions plausibly related to symbiotic interactions with the host, including ExpE6, IdhA, MocB, Gor, PckA, LeuC, and AglE. Seven of 10 single-crossover beta-glucuronidase (GUS) transcriptional reporters in genes corresponding to QS-regulated proteins showed significantly different activities in the sinI and expR mutant backgrounds and in response to added SinI AHLs. The sinI mutant and several of the single-crossover strains were significantly delayed in the ability to initiate nodules on the primary root of the host plant, Medicago truncatula, indicating that sinI-dependent QS regulation and QS-regulated proteins contribute importantly to the rate or efficiency of nodule initiation. The sinI and expR mutants were also defective in surface swarming motility. The sinI mutant was restored to normal swarming by 5 nM C(16:1)-HSL.

  13. sinI- and expR-Dependent Quorum Sensing in Sinorhizobium meliloti†

    PubMed Central

    Gao, Mengsheng; Chen, Hancai; Eberhard, Anatol; Gronquist, Matthew R.; Robinson, Jayne B.; Rolfe, Barry G.; Bauer, Wolfgang D.

    2005-01-01

    Quorum sensing (QS) in Sinorhizobium meliloti, the N-fixing bacterial symbiont of Medicago host plants, involves at least half a dozen different N-acyl homoserine lactone (AHL) signals and perhaps an equal number of AHL receptors. The accumulation of 55 proteins was found to be dependent on SinI, the AHL synthase, and/or on ExpR, one of the AHL receptors. Gas chromatography-mass spectrometry and electrospray ionization tandem mass spectrometry identified 3-oxo-C14-homoserine lactone (3-oxo-C14-HSL), C16-HSL, 3-oxo-C16-HSL, C16:1-HSL, and 3-oxo-C16:1-HSL as the sinI-dependent AHL QS signals accumulated by the 8530 expR+ strain under the conditions used for proteome analysis. The 8530 expR+ strain secretes additional, unidentified QS-active compounds. Addition of 200 nM C14-HSL or C16:1-HSL, two of the known SinI AHLs, affected the levels of 75% of the proteins, confirming that their accumulation is QS regulated. A number of the QS-regulated proteins have functions plausibly related to symbiotic interactions with the host, including ExpE6, IdhA, MocB, Gor, PckA, LeuC, and AglE. Seven of 10 single-crossover β-glucuronidase (GUS) transcriptional reporters in genes corresponding to QS-regulated proteins showed significantly different activities in the sinI and expR mutant backgrounds and in response to added SinI AHLs. The sinI mutant and several of the single-crossover strains were significantly delayed in the ability to initiate nodules on the primary root of the host plant, Medicago truncatula, indicating that sinI-dependent QS regulation and QS-regulated proteins contribute importantly to the rate or efficiency of nodule initiation. The sinI and expR mutants were also defective in surface swarming motility. The sinI mutant was restored to normal swarming by 5 nM C16:1-HSL. PMID:16291666

  14. SinEx DB: a database for single exon coding sequences in mammalian genomes.

    PubMed

    Jorquera, Roddy; Ortiz, Rodrigo; Ossandon, F; Cárdenas, Juan Pablo; Sepúlveda, Rene; González, Carolina; Holmes, David S

    2016-01-01

    Eukaryotic genes are typically interrupted by intragenic, noncoding sequences termed introns. However, some genes lack introns in their coding sequence (CDS) and are generally known as 'single exon genes' (SEGs). In this work, a SEG is defined as a nuclear, protein-coding gene that lacks introns in its CDS. Whereas, many public databases of Eukaryotic multi-exon genes are available, there are only two specialized databases for SEGs. The present work addresses the need for a more extensive and diverse database by creating SinEx DB, a publicly available, searchable database of predicted SEGs from 10 completely sequenced mammalian genomes including human. SinEx DB houses the DNA and protein sequence information of these SEGs and includes their functional predictions (KOG) and the relative distribution of these functions within species. The information is stored in a relational database built with My SQL Server 5.1.33 and the complete dataset of SEG sequences and their functional predictions are available for downloading. SinEx DB can be interrogated by: (i) a browsable phylogenetic schema, (ii) carrying out BLAST searches to the in-house SinEx DB of SEGs and (iii) via an advanced search mode in which the database can be searched by key words and any combination of searches by species and predicted functions. SinEx DB provides a rich source of information for advancing our understanding of the evolution and function of SEGs.Database URL: www.sinex.cl.

  15. SinEx DB: a database for single exon coding sequences in mammalian genomes

    PubMed Central

    Jorquera, Roddy; Ortiz, Rodrigo; Ossandon, F.; Cárdenas, Juan Pablo; Sepúlveda, Rene; González, Carolina; Holmes, David S.

    2016-01-01

    Eukaryotic genes are typically interrupted by intragenic, noncoding sequences termed introns. However, some genes lack introns in their coding sequence (CDS) and are generally known as ‘single exon genes’ (SEGs). In this work, a SEG is defined as a nuclear, protein-coding gene that lacks introns in its CDS. Whereas, many public databases of Eukaryotic multi-exon genes are available, there are only two specialized databases for SEGs. The present work addresses the need for a more extensive and diverse database by creating SinEx DB, a publicly available, searchable database of predicted SEGs from 10 completely sequenced mammalian genomes including human. SinEx DB houses the DNA and protein sequence information of these SEGs and includes their functional predictions (KOG) and the relative distribution of these functions within species. The information is stored in a relational database built with My SQL Server 5.1.33 and the complete dataset of SEG sequences and their functional predictions are available for downloading. SinEx DB can be interrogated by: (i) a browsable phylogenetic schema, (ii) carrying out BLAST searches to the in-house SinEx DB of SEGs and (iii) via an advanced search mode in which the database can be searched by key words and any combination of searches by species and predicted functions. SinEx DB provides a rich source of information for advancing our understanding of the evolution and function of SEGs. Database URL: www.sinex.cl PMID:27278816

  16. SinEx DB: a database for single exon coding sequences in mammalian genomes.

    PubMed

    Jorquera, Roddy; Ortiz, Rodrigo; Ossandon, F; Cárdenas, Juan Pablo; Sepúlveda, Rene; González, Carolina; Holmes, David S

    2016-01-01

    Eukaryotic genes are typically interrupted by intragenic, noncoding sequences termed introns. However, some genes lack introns in their coding sequence (CDS) and are generally known as 'single exon genes' (SEGs). In this work, a SEG is defined as a nuclear, protein-coding gene that lacks introns in its CDS. Whereas, many public databases of Eukaryotic multi-exon genes are available, there are only two specialized databases for SEGs. The present work addresses the need for a more extensive and diverse database by creating SinEx DB, a publicly available, searchable database of predicted SEGs from 10 completely sequenced mammalian genomes including human. SinEx DB houses the DNA and protein sequence information of these SEGs and includes their functional predictions (KOG) and the relative distribution of these functions within species. The information is stored in a relational database built with My SQL Server 5.1.33 and the complete dataset of SEG sequences and their functional predictions are available for downloading. SinEx DB can be interrogated by: (i) a browsable phylogenetic schema, (ii) carrying out BLAST searches to the in-house SinEx DB of SEGs and (iii) via an advanced search mode in which the database can be searched by key words and any combination of searches by species and predicted functions. SinEx DB provides a rich source of information for advancing our understanding of the evolution and function of SEGs.Database URL: www.sinex.cl. PMID:27278816

  17. Improving Estimates of m sin i by Expanding RV Data Sets

    NASA Astrophysics Data System (ADS)

    Brown, Robert A.

    2016-07-01

    We develop new techniques for estimating the fractional uncertainty ({ F }) in the projected planetary mass (m sin i) resulting from Keplerian fits to radial-velocity (RV) data sets of known Jupiter-class exoplanets. The techniques include (1) estimating the distribution of m sin i using projection, (2) detecting and mitigating chimeras, a source of systematic error, and (3) estimating the reduction in the uncertainty in m sin i if hypothetical observations were made in the future. We demonstrate the techniques on a representative set of RV exoplanets, known as the Sample of 27, which are candidates for detection and characterization by a future astrometric direct imaging mission. We estimate the improvements (reductions) in { F } due to additional, hypothetical RV measurements obtained in the future. We encounter and address a source of systematic error, “chimeras,” which can appear when multiple types of Keplerian solutions are compatible with a single data set.

  18. Genetic and Physical Interactions between Yeast Rgr1 and Sin4 in Chromatin Organization and Transcriptional Regulation

    PubMed Central

    Jiang, Y. W.; Dohrmann, P. R.; Stillman, D. J.

    1995-01-01

    The SIN4 and RGR1 genes of Saccharomyces cerevisiae were identified by mutations in quite different genetic screens. We have shown that the SIN4 gene product is required for proper transcriptional regulation of many genes and that a sin4 mutation can affect either activation or repression of specific genes. We have suggested that this dual nature of SIN4 in transcriptional regulation is due to its involvement in chromatin organization. We now report that the role of RGR1 in gene regulation is similar to that of SIN4. SIN4 and RGR1 both function as negative transcriptional regulators of HO and IME1, and mutations in either gene lead to decreased expression of other genes including CTS1. Strains with sin4 or rgr1 mutations both have phenotypes similar to those caused by histone mutations, including suppression of {delta small} insertion into promoters (Spt- phenotype), activation of promoters lacking UAS elements, and decreased superhelical density of plasmid DNA molecules. Overexpression of RGR1 suppresses the temperature sensitivity due to a sin4 mutation. Finally, we use yeast strains expressing GST fusion proteins to demonstrate that the Sin4p and Rgr1p proteins are physically associated in vivo. These results indicate that Sin4p and Rgr1p act together in vivo to organize chromatin structure and thus regulate transcription. PMID:7635307

  19. Isolation and characterization of the modification methylase M . SinI.

    PubMed Central

    Karreman, C; de Waard, A

    1988-01-01

    A sequence-specific modification methylase (M . SinI) was isolated and purified from Escherichia coli harboring a derivative of recombinant plasmid pSI4 (see accompanying manuscript: C. Karreman and A. de Waard, J. Bacteriol. 170:2527-2532, 1988), which contains a Salmonella infantis DNA insert. The enzyme uniquely methylates the internal deoxycytidylate residue in the nucleotide sequence GG(A/T)MeCC, thereby protecting DNA completely against cleavage by restriction endonuclease R . SinI or R . AvaII [GG(A/T)CC], and in part against cleavage by R . Sau96I (GGNCC). Images PMID:2836360

  20. Fabrication of high-quality superconductor-insulator-superconductor junctions on thin SiN membranes

    NASA Technical Reports Server (NTRS)

    Garcia, Edouard; Jacobson, Brian R.; Hu, Qing

    1993-01-01

    We have successfully fabricated high-quality and high-current density superconductor-insulator-superconductor (SIS) junctions on freestanding thin silicon nitride (SIN) membranes. These devices can be used in a novel millimeter-wave and THz receiver system which is made using micromachining. The SIS junctions with planar antennas were fabricated first on a silicon wafer covered with a SiN membrane, the Si wafer underneath was then etched away using an anisotropic KOH etchant. The current-voltage characteristics of the SIS junctions remained unchanged after the whole process, and the junctions and the membrane survived thermal cycling.

  1. Roots of Sin and Destruction of the Religious Education in the Shia Belief

    ERIC Educational Resources Information Center

    Sadeghiyan, Mehri

    2016-01-01

    The religious Education is one of the key components of the present age detachment from which poses numerous problems for the society Islamic. One of the factors effective in the destruction of the religious Education is the roots of sin avoiding which can lead to the improvement of the religious Education of the members of the society. Thus, the…

  2. A Method for Oscillation Errors Restriction of SINS Based on Forecasted Time Series.

    PubMed

    Zhao, Lin; Li, Jiushun; Cheng, Jianhua; Jia, Chun; Wang, Qiufan

    2015-01-01

    Continuity, real-time, and accuracy are the key technical indexes of evaluating comprehensive performance of a strapdown inertial navigation system (SINS). However, Schuler, Foucault, and Earth periodic oscillation errors significantly cut down the real-time accuracy of SINS. A method for oscillation error restriction of SINS based on forecasted time series is proposed by analyzing the characteristics of periodic oscillation errors. The innovative method gains multiple sets of navigation solutions with different phase delays in virtue of the forecasted time series acquired through the measurement data of the inertial measurement unit (IMU). With the help of curve-fitting based on least square method, the forecasted time series is obtained while distinguishing and removing small angular motion interference in the process of initial alignment. Finally, the periodic oscillation errors are restricted on account of the principle of eliminating the periodic oscillation signal with a half-wave delay by mean value. Simulation and test results show that the method has good performance in restricting the Schuler, Foucault, and Earth oscillation errors of SINS. PMID:26193283

  3. How Secondary Schools Can Avoid the Seven Deadly School "Sins" of Inclusion

    ERIC Educational Resources Information Center

    Worrell, Jamie L.

    2008-01-01

    As more students with disabilities are included in general education classrooms, many obstacles must be overcome before parents, teachers, students, and administrators deem inclusion effective. This article identifies seven "sins", which are barriers to inclusive practices in secondary schools: Negative teacher perspectives; lack of knowledge…

  4. Population dynamics of the deer mouse (Peromyscus maniculatus) and Sin Nombre virus, California Channel Islands.

    PubMed

    Graham, T B; Chomel, B B

    1997-01-01

    Hantavirus pulmonary syndrome, first documented in 1993, is caused by Sin Nombre virus (SNV), which is carried by the Peromyscus species. In 1994, high SNV antibody prevalence was identified in deer mice from two California Channel Islands. We sampled two locations on three islands to estimate mouse population density and SNV prevalence. Population flux and SNV prevalence appear to vary independently.

  5. Informe del NCI y los CDC sobre el tabaco sin humo

    Cancer.gov

    El primer informe sobre el consumo mundial del tabaco sin humo y sus consecuencias en la salud pública reveló que más de 300 millones de personas en al menos 70 países usan estos productos dañinos.

  6. A Method for Oscillation Errors Restriction of SINS Based on Forecasted Time Series

    PubMed Central

    Zhao, Lin; Li, Jiushun; Cheng, Jianhua; Jia, Chun; Wang, Qiufan

    2015-01-01

    Continuity, real-time, and accuracy are the key technical indexes of evaluating comprehensive performance of a strapdown inertial navigation system (SINS). However, Schuler, Foucault, and Earth periodic oscillation errors significantly cut down the real-time accuracy of SINS. A method for oscillation error restriction of SINS based on forecasted time series is proposed by analyzing the characteristics of periodic oscillation errors. The innovative method gains multiple sets of navigation solutions with different phase delays in virtue of the forecasted time series acquired through the measurement data of the inertial measurement unit (IMU). With the help of curve-fitting based on least square method, the forecasted time series is obtained while distinguishing and removing small angular motion interference in the process of initial alignment. Finally, the periodic oscillation errors are restricted on account of the principle of eliminating the periodic oscillation signal with a half-wave delay by mean value. Simulation and test results show that the method has good performance in restricting the Schuler, Foucault, and Earth oscillation errors of SINS. PMID:26193283

  7. Ten Sins Challenging Education in the Contemporary Global Era: A Philosophical Essay

    ERIC Educational Resources Information Center

    Sinagatullin, Ilghiz M.

    2004-01-01

    According to this author, the modern epoch is characterized by a decrease of vital spirituality and an increase of materialistic values and virtues. This article discusses what the author views as the ten sins challenging education in the contemporary global era. These are: (1) the shrinking of spiritual values; (2) corruption; (3) sexual…

  8. Campaign Sii Ha Sin: Shaping the Future of Tribal Colleges and Universities

    ERIC Educational Resources Information Center

    American Indian College Fund, 2004

    2004-01-01

    The impact of the American Indian College Fund's Campaign Sii Ha Sin has been immediate and profound. The capital campaign, appropriately named for the Navajo concept of hope, has helped establish the tribal colleges as a positive and central force in American Indian higher education, the communities served by the tribal colleges and ultimately,…

  9. Plagiarism and Other Sins Seem Rife in Science Journals, a Digital Sleuth Finds

    ERIC Educational Resources Information Center

    Guterman, Lila

    2008-01-01

    Faculty members gnash their teeth and wring their hands when students plagiarize. They cry for offenders to be punished. But now an online text-search program directed at their own work suggests that professors in biomedicine may be just as guilty of paper-writing sins. More than 70,000 article abstracts appeared disturbingly similar to other…

  10. Stress-mediated Sin3B activation leads to negative regulation of subset of p53 target genes.

    PubMed

    Kadamb, Rama; Mittal, Shilpi; Bansal, Nidhi; Saluja, Daman

    2015-01-01

    The multiprotein SWI-independent 3 (Sin3)-HDAC (histone deacetylase) corepressor complex mediates gene repression through its interaction with DNA-binding factors and recruitment of chromatin-modifying proteins on to the promoters of target gene. Previously, an increased expression of Sin3B and tumour suppressor protein, p53 has been established upon adriamycin treatment. We, now provide evidence that Sin3B expression is significantly up-regulated under variety of stress conditions and this response is not stress-type specific. We observed that Sin3B expression is significantly up-regulated both at transcript and at protein level upon DNA damage induced by bleomycin drug, a radiomimetic agent. This increase in Sin3B expression upon stress is found to be p53-dependent and is associated with enhanced interaction of Sin3B with Ser(15) phosphorylated p53. Binding of Sin3-HDAC repressor complex on to the promoters of p53 target genes influences gene regulation by altering histone modifications (H3K9me3 and H3K27me3) at target genes. Furthermore, knockdown of Sin3B by shRNA severely compromises p53-mediated gene repression under stress conditions. Taken together, these results suggest that stress-induced Sin3B activation is p53-dependent and is essential for p53-mediated repression of its selective target genes. The present study has an implication in understanding the transrepression mechanism of p53 under DNA damaging conditions.

  11. Bicarbonate plays a critical role in the generation of cytotoxicity during SIN-1 decomposition in culture medium.

    PubMed

    Shirai, Kyo; Okada, Tatsumi; Konishi, Kanako; Murata, Hiroshi; Akashi, Soichiro; Sugawara, Fumio; Watanabe, Nobuo; Arai, Takao

    2012-01-01

    3-Morpholinosydnonimine (SIN-1) is used as a donor of peroxynitrite (ONOO(-)) in various studies. We demonstrated, however, that, the cell-culture medium remains cytotoxic to PC12 cells even after almost complete SIN-1 decomposition, suggesting that reaction product(s) in the medium, rather than ONOO(-), exert cytotoxic effects. Here, we clarified that significant cytotoxicity persists after SIN-1 decomposes in bicarbonate, a component of the culture medium, but not in NaOH. Cytotoxic SIN-1-decomposed bicarbonate, which lacks both oxidizing and nitrosating activities, degrades to innocuous state over time. The extent of SIN-1 cytotoxicity, irrespective of its fresh or decomposed state, appears to depend on the total number of initial SIN-1 molecules per cell, rather than its concentration, and involves oxidative/nitrosative stress-related cell damage. These results suggest that, despite its low abundance, the bicarbonate-dependent cytotoxic substance that accumulates in the medium during SIN-1 breakdown is the cytotoxic entity of SIN-1. PMID:22848780

  12. The Adapter Molecule Sin Regulates T-Cell-Receptor-Mediated Signal Transduction by Modulating Signaling Substrate Availability

    PubMed Central

    Xing, Luzhou; Donlin, Laura T.; Miller, Rebecca H.; Alexandropoulos, Konstantina

    2004-01-01

    Engagement of the T-cell receptor (TCR) results in the activation of a multitude of signaling events that regulate the function of T lymphocytes. These signaling events are in turn modulated by adapter molecules, which control the final functional output through the formation of multiprotein complexes. In this report, we identified the adapter molecule Sin as a new regulator of T-cell activation. We found that the expression of Sin in transgenic T lymphocytes and Jurkat T cells inhibited interleukin-2 expression and T-cell proliferation. This inhibitory effect was specific and was due to defective phospholipase C-γ (PLC-γ) phosphorylation and activation. In contrast to other adapters that become phosphorylated upon TCR stimulation, Sin was constitutively phosphorylated in resting cells by the Src kinase Fyn and bound to signaling intermediates, including PLC-γ. In stimulated cells, Sin was transiently dephosphorylated, which coincided with transient dissociation of Fyn and PLC-γ. Downregulation of Sin expression using Sin-specific short interfering RNA oligonucleotides inhibited transcriptional activation in response to TCR stimulation. Our results suggest that endogenous Sin influences T-lymphocyte signaling by sequestering signaling substrates and regulating their availability and/or activity in resting cells, while Sin is required for targeting these intermediates to the TCR for fast signal transmission during stimulation. PMID:15121874

  13. Constructing a Counternarrative: Students Informing Now (S.I.N.) Reframes Immigration and Education in the United States

    ERIC Educational Resources Information Center

    Dominguez, Neidi; Duarte, Yazmin; Espinosa, Pedro Joel; Martinez, Luis; Nygreen, Kysa; Perez, Renato; Ramirez, Izel; Saba, Mariella

    2009-01-01

    The work of Students Informing Now (S.I.N.), an immigrant student organization at the University of California, Santa Cruz, is described in this column. The authors argue that S.I.N.'s diverse activities and textual products construct a counternarrative that challenges and reframes the debate on undocumented students and immigration. Focusing on…

  14. Bicarbonate plays a critical role in the generation of cytotoxicity during SIN-1 decomposition in culture medium.

    PubMed

    Shirai, Kyo; Okada, Tatsumi; Konishi, Kanako; Murata, Hiroshi; Akashi, Soichiro; Sugawara, Fumio; Watanabe, Nobuo; Arai, Takao

    2012-01-01

    3-Morpholinosydnonimine (SIN-1) is used as a donor of peroxynitrite (ONOO(-)) in various studies. We demonstrated, however, that, the cell-culture medium remains cytotoxic to PC12 cells even after almost complete SIN-1 decomposition, suggesting that reaction product(s) in the medium, rather than ONOO(-), exert cytotoxic effects. Here, we clarified that significant cytotoxicity persists after SIN-1 decomposes in bicarbonate, a component of the culture medium, but not in NaOH. Cytotoxic SIN-1-decomposed bicarbonate, which lacks both oxidizing and nitrosating activities, degrades to innocuous state over time. The extent of SIN-1 cytotoxicity, irrespective of its fresh or decomposed state, appears to depend on the total number of initial SIN-1 molecules per cell, rather than its concentration, and involves oxidative/nitrosative stress-related cell damage. These results suggest that, despite its low abundance, the bicarbonate-dependent cytotoxic substance that accumulates in the medium during SIN-1 breakdown is the cytotoxic entity of SIN-1.

  15. Reflections on "Multiplication as Original Sin": The Implications of Using a Case to Help Preservice Teachers Understand Invented Algorithms

    ERIC Educational Resources Information Center

    Harkness, Shelly Sheats; Thomas, Jonathan

    2008-01-01

    This article describes the use of a case report, Multiplication as original sin (Corwin, R. B. (1989). "Multiplication as original sin." "Journal of Mathematical Behavior, 8", 223-225), as an assignment in a mathematics course for preservice elementary teachers. In this case study, Corwin described her experience as a 6th grader when she revealed…

  16. Novel liquid chromatography-mass spectrometry method for sensitive determination of the mustard allergen Sin a 1 in food.

    PubMed

    Posada-Ayala, Maria; Alvarez-Llamas, Gloria; Maroto, Aroa S; Maes, Xavier; Muñoz-Garcia, Esther; Villalba, Mayte; Rodríguez, Rosalía; Perez-Gordo, Marina; Vivanco, Fernando; Pastor-Vargas, Carlos; Cuesta-Herranz, Javier

    2015-09-15

    Mustard is a condiment added to a variety of foodstuffs and a frequent cause of food allergy. A new strategy for the detection of mustard allergen in food products is presented. The methodology is based on liquid chromatography analysis coupled to mass spectrometry. Mustard allergen Sin a 1 was purified from yellow mustard seeds. Sin a 1 was detected with a total of five peptides showing a linear response (lowest LOD was 5ng). Sin a 1 was detected in mustard sauces and salty biscuit (19±3mg/kg) where mustard content is not specified. Sin a 1, used as an internal standard, allowed quantification of this mustard allergen in foods. A novel LC/MS/MS SRM-based method has been developed to detect and quantify the presence of mustard. This method could help to detect mustard allergen Sin a 1 in processed foods and protect mustard-allergic consumers. PMID:25863610

  17. "... As we forgive those who trespass against us...": theological reflections on sin and guilt in the hospital environment.

    PubMed

    Schmidt, Kurt W

    2005-08-01

    In general parlance the term sin has lost its existential meaning. Originally a Jewish-Christian term within a purely religious context, referring to a wrongdoing with regard to God, sin has slowly become reduced to guilt in the course of the secularization process. Guilt refers to a wrongdoing, especially with regard to fellow human beings. It also refers to errors of judgement with what can be tragic consequences. These errors can occur whenever human beings are called upon to act, including the hospital environment. A Christian hospital has to address the issue of how to deal not only with guilt-ridden misdemeanors, but also with wrongdoing unto God, which overshadows every instance of guilt-ridden human behavior. Here, as in every parish, the Church Service is the place to acknowledge sin, confess sin, and forgive sin, beyond the boundaries of the parish itself.

  18. Novel liquid chromatography-mass spectrometry method for sensitive determination of the mustard allergen Sin a 1 in food.

    PubMed

    Posada-Ayala, Maria; Alvarez-Llamas, Gloria; Maroto, Aroa S; Maes, Xavier; Muñoz-Garcia, Esther; Villalba, Mayte; Rodríguez, Rosalía; Perez-Gordo, Marina; Vivanco, Fernando; Pastor-Vargas, Carlos; Cuesta-Herranz, Javier

    2015-09-15

    Mustard is a condiment added to a variety of foodstuffs and a frequent cause of food allergy. A new strategy for the detection of mustard allergen in food products is presented. The methodology is based on liquid chromatography analysis coupled to mass spectrometry. Mustard allergen Sin a 1 was purified from yellow mustard seeds. Sin a 1 was detected with a total of five peptides showing a linear response (lowest LOD was 5ng). Sin a 1 was detected in mustard sauces and salty biscuit (19±3mg/kg) where mustard content is not specified. Sin a 1, used as an internal standard, allowed quantification of this mustard allergen in foods. A novel LC/MS/MS SRM-based method has been developed to detect and quantify the presence of mustard. This method could help to detect mustard allergen Sin a 1 in processed foods and protect mustard-allergic consumers.

  19. An Improved Inertial Frame Alignment Algorithm Based on Horizontal Alignment Information for Marine SINS.

    PubMed

    Che, Yanting; Wang, Qiuying; Gao, Wei; Yu, Fei

    2015-01-01

    In this paper, an improved inertial frame alignment algorithm for a marine SINS under mooring conditions is proposed, which significantly improves accuracy. Since the horizontal alignment is easy to complete, and a characteristic of gravity is that its component in the horizontal plane is zero, we use a clever method to improve the conventional inertial alignment algorithm. Firstly, a large misalignment angle model and a dimensionality reduction Gauss-Hermite filter are employed to establish the fine horizontal reference frame. Based on this, the projection of the gravity in the body inertial coordinate frame can be calculated easily. Then, the initial alignment algorithm is accomplished through an inertial frame alignment algorithm. The simulation and experiment results show that the improved initial alignment algorithm performs better than the conventional inertial alignment algorithm, and meets the accuracy requirements of a medium-accuracy marine SINS.

  20. AUV Underwater Positioning Algorithm Based on Interactive Assistance of SINS and LBL.

    PubMed

    Zhang, Tao; Chen, Liping; Li, Yao

    2015-01-01

    This paper studies an underwater positioning algorithm based on the interactive assistance of a strapdown inertial navigation system (SINS) and LBL, and this algorithm mainly includes an optimal correlation algorithm with aided tracking of an SINS/Doppler velocity log (DVL)/magnetic compass pilot (MCP), a three-dimensional TDOA positioning algorithm of Taylor series expansion and a multi-sensor information fusion algorithm. The final simulation results show that compared to traditional underwater positioning algorithms, this scheme can not only directly correct accumulative errors caused by a dead reckoning algorithm, but also solves the problem of ambiguous correlation peaks caused by multipath transmission of underwater acoustic signals. The proposed method can calibrate the accumulative error of the AUV position more directly and effectively, which prolongs the underwater operating duration of the AUV. PMID:26729120

  1. AUV Underwater Positioning Algorithm Based on Interactive Assistance of SINS and LBL

    PubMed Central

    Zhang, Tao; Chen, Liping; Li, Yao

    2015-01-01

    This paper studies an underwater positioning algorithm based on the interactive assistance of a strapdown inertial navigation system (SINS) and LBL, and this algorithm mainly includes an optimal correlation algorithm with aided tracking of an SINS/Doppler velocity log (DVL)/magnetic compass pilot (MCP), a three-dimensional TDOA positioning algorithm of Taylor series expansion and a multi-sensor information fusion algorithm. The final simulation results show that compared to traditional underwater positioning algorithms, this scheme can not only directly correct accumulative errors caused by a dead reckoning algorithm, but also solves the problem of ambiguous correlation peaks caused by multipath transmission of underwater acoustic signals. The proposed method can calibrate the accumulative error of the AUV position more directly and effectively, which prolongs the underwater operating duration of the AUV. PMID:26729120

  2. AUV Underwater Positioning Algorithm Based on Interactive Assistance of SINS and LBL.

    PubMed

    Zhang, Tao; Chen, Liping; Li, Yao

    2015-12-30

    This paper studies an underwater positioning algorithm based on the interactive assistance of a strapdown inertial navigation system (SINS) and LBL, and this algorithm mainly includes an optimal correlation algorithm with aided tracking of an SINS/Doppler velocity log (DVL)/magnetic compass pilot (MCP), a three-dimensional TDOA positioning algorithm of Taylor series expansion and a multi-sensor information fusion algorithm. The final simulation results show that compared to traditional underwater positioning algorithms, this scheme can not only directly correct accumulative errors caused by a dead reckoning algorithm, but also solves the problem of ambiguous correlation peaks caused by multipath transmission of underwater acoustic signals. The proposed method can calibrate the accumulative error of the AUV position more directly and effectively, which prolongs the underwater operating duration of the AUV.

  3. An Improved Inertial Frame Alignment Algorithm Based on Horizontal Alignment Information for Marine SINS

    PubMed Central

    Che, Yanting; Wang, Qiuying; Gao, Wei; Yu, Fei

    2015-01-01

    In this paper, an improved inertial frame alignment algorithm for a marine SINS under mooring conditions is proposed, which significantly improves accuracy. Since the horizontal alignment is easy to complete, and a characteristic of gravity is that its component in the horizontal plane is zero, we use a clever method to improve the conventional inertial alignment algorithm. Firstly, a large misalignment angle model and a dimensionality reduction Gauss-Hermite filter are employed to establish the fine horizontal reference frame. Based on this, the projection of the gravity in the body inertial coordinate frame can be calculated easily. Then, the initial alignment algorithm is accomplished through an inertial frame alignment algorithm. The simulation and experiment results show that the improved initial alignment algorithm performs better than the conventional inertial alignment algorithm, and meets the accuracy requirements of a medium-accuracy marine SINS. PMID:26445048

  4. Sin Fronteras Boy: Students Create Collaborative Websites to Explore the Border

    ERIC Educational Resources Information Center

    Cornell, Grace

    2012-01-01

    Around one table, four 4th-grade girls chat quietly as they write on their laptops: Ruby interviews Alejandra about her experience crossing the U.S.-Mexico border as a 6-year-old. Meanwhile, Cindy turns notes from an interview with her uncle into a narrative about his immigration experience. Next to them, four boys work on the "Sin Fronteras Boy"…

  5. Ultra-sensitive cryogenic thermometer based on an array of the SIN tunnel junctions

    NASA Astrophysics Data System (ADS)

    Kuzmin, Leonid

    2008-02-01

    A novel concept of an ultra-sensitive thermometer based on a series array of superconductor-insulator-normal (SIN) tunnel junctions has been proposed. The array helps to improve matching with an amplifier proportionally to the number of junctions. There is no fundamental limit for total noise and the main limitation is electron-phonon noise of the normal island reverse proportional to volume of the normal metal.

  6. Initial Alignment of Large Azimuth Misalignment Angles in SINS Based on Adaptive UPF

    PubMed Central

    Sun, Jin; Xu, Xiao-Su; Liu, Yi-Ting; Zhang, Tao; Li, Yao

    2015-01-01

    The case of large azimuth misalignment angles in a strapdown inertial navigation system (SINS) is analyzed, and a method of using the adaptive UPF for the initial alignment is proposed. The filter is based on the idea of a strong tracking filter; through the introduction of the attenuation memory factor to effectively enhance the corrections of the current information residual error on the system, it reduces the influence on the system due to the system simplification, and the uncertainty of noise statistical properties to a certain extent; meanwhile, the UPF particle degradation phenomenon is better overcome. Finally, two kinds of non-linear filters, UPF and adaptive UPF, are adopted in the initial alignment of large azimuth misalignment angles in SINS, and the filtering effects of the two kinds of nonlinear filter on the initial alignment were compared by simulation and turntable experiments. The simulation and turntable experiment results show that the speed and precision of the initial alignment using adaptive UPF for a large azimuth misalignment angle in SINS under the circumstance that the statistical properties of the system noise are certain or not have been improved to some extent. PMID:26334277

  7. A novel scheme for DVL-aided SINS in-motion alignment using UKF techniques.

    PubMed

    Li, Wanli; Wang, Jinling; Lu, Liangqing; Wu, Wenqi

    2013-01-01

    In-motion alignment of Strapdown Inertial Navigation Systems (SINS) without any geodetic-frame observations is one of the toughest challenges for Autonomous Underwater Vehicles (AUV). This paper presents a novel scheme for Doppler Velocity Log (DVL) aided SINS alignment using Unscented Kalman Filter (UKF) which allows large initial misalignments. With the proposed mechanism, a nonlinear SINS error model is presented and the measurement model is derived under the assumption that large misalignments may exist. Since a priori knowledge of the measurement noise covariance is of great importance to robustness of the UKF, the covariance-matching methods widely used in the Adaptive KF (AKF) are extended for use in Adaptive UKF (AUKF). Experimental results show that the proposed DVL-aided alignment model is effective with any initial heading errors. The performances of the adaptive filtering methods are evaluated with regards to their parameter estimation stability. Furthermore, it is clearly shown that the measurement noise covariance can be estimated reliably by the adaptive UKF methods and hence improve the performance of the alignment. PMID:23322105

  8. Initial Alignment of Large Azimuth Misalignment Angles in SINS Based on Adaptive UPF.

    PubMed

    Sun, Jin; Xu, Xiao-Su; Liu, Yi-Ting; Zhang, Tao; Li, Yao

    2015-01-01

    The case of large azimuth misalignment angles in a strapdown inertial navigation system (SINS) is analyzed, and a method of using the adaptive UPF for the initial alignment is proposed. The filter is based on the idea of a strong tracking filter; through the introduction of the attenuation memory factor to effectively enhance the corrections of the current information residual error on the system, it reduces the influence on the system due to the system simplification, and the uncertainty of noise statistical properties to a certain extent; meanwhile, the UPF particle degradation phenomenon is better overcome. Finally, two kinds of non-linear filters, UPF and adaptive UPF, are adopted in the initial alignment of large azimuth misalignment angles in SINS, and the filtering effects of the two kinds of nonlinear filter on the initial alignment were compared by simulation and turntable experiments. The simulation and turntable experiment results show that the speed and precision of the initial alignment using adaptive UPF for a large azimuth misalignment angle in SINS under the circumstance that the statistical properties of the system noise are certain or not have been improved to some extent. PMID:26334277

  9. A Novel Scheme for DVL-Aided SINS In-Motion Alignment Using UKF Techniques

    PubMed Central

    Li, Wanli; Wang, Jinling; Lu, Liangqing; Wu, Wenqi

    2013-01-01

    In-motion alignment of Strapdown Inertial Navigation Systems (SINS) without any geodetic-frame observations is one of the toughest challenges for Autonomous Underwater Vehicles (AUV). This paper presents a novel scheme for Doppler Velocity Log (DVL) aided SINS alignment using Unscented Kalman Filter (UKF) which allows large initial misalignments. With the proposed mechanism, a nonlinear SINS error model is presented and the measurement model is derived under the assumption that large misalignments may exist. Since a priori knowledge of the measurement noise covariance is of great importance to robustness of the UKF, the covariance-matching methods widely used in the Adaptive KF (AKF) are extended for use in Adaptive UKF (AUKF). Experimental results show that the proposed DVL-aided alignment model is effective with any initial heading errors. The performances of the adaptive filtering methods are evaluated with regards to their parameter estimation stability. Furthermore, it is clearly shown that the measurement noise covariance can be estimated reliably by the adaptive UKF methods and hence improve the performance of the alignment. PMID:23322105

  10. A novel scheme for DVL-aided SINS in-motion alignment using UKF techniques.

    PubMed

    Li, Wanli; Wang, Jinling; Lu, Liangqing; Wu, Wenqi

    2013-01-15

    In-motion alignment of Strapdown Inertial Navigation Systems (SINS) without any geodetic-frame observations is one of the toughest challenges for Autonomous Underwater Vehicles (AUV). This paper presents a novel scheme for Doppler Velocity Log (DVL) aided SINS alignment using Unscented Kalman Filter (UKF) which allows large initial misalignments. With the proposed mechanism, a nonlinear SINS error model is presented and the measurement model is derived under the assumption that large misalignments may exist. Since a priori knowledge of the measurement noise covariance is of great importance to robustness of the UKF, the covariance-matching methods widely used in the Adaptive KF (AKF) are extended for use in Adaptive UKF (AUKF). Experimental results show that the proposed DVL-aided alignment model is effective with any initial heading errors. The performances of the adaptive filtering methods are evaluated with regards to their parameter estimation stability. Furthermore, it is clearly shown that the measurement noise covariance can be estimated reliably by the adaptive UKF methods and hence improve the performance of the alignment.

  11. Stress-mediated Sin3B activation leads to negative regulation of subset of p53 target genes

    PubMed Central

    Kadamb, Rama; Mittal, Shilpi; Bansal, Nidhi; Saluja, Daman

    2015-01-01

    The multiprotein SWI-independent 3 (Sin3)–HDAC (histone deacetylase) corepressor complex mediates gene repression through its interaction with DNA-binding factors and recruitment of chromatin-modifying proteins on to the promoters of target gene. Previously, an increased expression of Sin3B and tumour suppressor protein, p53 has been established upon adriamycin treatment. We, now provide evidence that Sin3B expression is significantly up-regulated under variety of stress conditions and this response is not stress-type specific. We observed that Sin3B expression is significantly up-regulated both at transcript and at protein level upon DNA damage induced by bleomycin drug, a radiomimetic agent. This increase in Sin3B expression upon stress is found to be p53-dependent and is associated with enhanced interaction of Sin3B with Ser15 phosphorylated p53. Binding of Sin3–HDAC repressor complex on to the promoters of p53 target genes influences gene regulation by altering histone modifications (H3K9me3 and H3K27me3) at target genes. Furthermore, knockdown of Sin3B by shRNA severely compromises p53-mediated gene repression under stress conditions. Taken together, these results suggest that stress-induced Sin3B activation is p53-dependent and is essential for p53-mediated repression of its selective target genes. The present study has an implication in understanding the transrepression mechanism of p53 under DNA damaging conditions. PMID:26181367

  12. Twist-four effects in deep inelastic neutrino scattering and sinStheta/sub w/

    SciTech Connect

    Fajfer, S.; Oakes, R.J.

    1985-07-01

    In addition to the standard perturbative QCD corrections to deep inelastic scattering, there are nonperturbative twist-four corrections which behave like 1/QS relative to the lnQS leading log corrections. We have calculated the twist-four, spin-one and spin-two corrections to sigma/sub NC/, sigma/sub CC/, R/sub nu/ and R/sub anti nu/ using the following procedure: The bilocal product of the weak currents is expanded into local operators using the Wilson operator product expansion. The coefficient functions obey the renormalization group equations and, neglecting the anomalous dimensions of the operators, were calculated using perturbative techniques. The nucleon matrix elements of the local operators can then be evaluated assuming some quark confinement model. We found that twist-four, spin-two corrections to the neutral current neutrino scattering decreases sinStheta/sub w/ by about 1%. Taking into account the twist-four, spin-two corrections for the charged current cross section, we found that they give a dominant contribution to the ratio R/sub nu/ and increased sinStheta/sub w/ by about 0.5%. We also have studied the model dependence of our results, and we have found that the twist-four, spin-two corrections to sinStheta/sub w/ are quite model dependent. The twist-four, spin-one corrections to the neutrino scattering were also calculated. These corrections come from two-quark, one-gluon operators and even at low QS their contribution was found to be considerably smaller than the twist-four, spin-two corrections.

  13. Effects of Tumor Necrosis Factor Alpha on Sin Nombre Virus Infection In Vitro

    PubMed Central

    Khaiboullina, Svetlana F.; Netski, Dale M.; Krumpe, Peter; St. Jeor, Stephen C.

    2000-01-01

    Previous data indicate that immune mechanisms may be involved in developing capillary leakage during Sin Nombre virus (SNV) infection. Therefore, we investigated production of tumor necrosis factor alpha (TNF-α) by human alveolar macrophages and human umbilical vein endothelial cells (HUVEC) after infection with SNV. In addition, we examined the effect of TNF-α on HUVEC monolayer leakage. Our results reveal that although TNF-α decreases accumulation of viral nucleoproteins, TNF-α levels do not change in SNV-infected cells. In addition, supernatants from SNV-infected human alveolar macrophages did not cause a significant increase in endothelial monolayer permeability. PMID:11090198

  14. [Institutional renovation and scientific modernization: the creation of the Instituto de Investigaciones Hematológicas during the mid-1950s].

    PubMed

    Buschini, José

    2013-12-01

    Using documentary sources, this work analyzes the creation and initial functioning of the Instituto de Investigaciones Hematológicas (Institute of Hematological Research) of the National Academy of Medicine (Buenos Aires, Argentina) in the context of the scientific modernization initiated within the country during the mid-1950s. Particular attention is paid to the generation of material bases and institutional and cultural mechanisms for the development of scientific research and of clinical practices guided by procedures and techniques rooted in the basic sciences. The formation and development of a research school in the Experimental Leukemia Section of the institute is explored as a case illustrative of the effective consolidation of initiatives oriented towards the organization of a scientific center.

  15. Stress engineering in GaN structures grown on Si(111) substrates by SiN masking layer application

    SciTech Connect

    Szymański, Tomasz Wośko, Mateusz; Paszkiewicz, Bogdan; Paszkiewicz, Regina

    2015-07-15

    GaN layers without and with an in-situ SiN mask were grown by using metal organic vapor phase epitaxy for three different approaches used in GaN on silicon(111) growth, and the physical and optical properties of the GaN layers were studied. For each approach applied, GaN layers of 1.4 μm total thickness were grown, using silan SiH{sub 4} as Si source in order to grow Si{sub x}N{sub x} masking layer. The optical micrographs, scanning electron microscope images, and atomic force microscope images of the grown samples revealed cracks for samples without SiN mask, and micropits, which were characteristic for the samples grown with SiN mask. In situ reflectance signal traces were studied showing a decrease of layer coalescence time and higher degree of 3D growth mode for samples with SiN masking layer. Stress measurements were conducted by two methods—by recording micro-Raman spectra and ex-situ curvature radius measurement—additionally PLs spectra were obtained revealing blueshift of PL peak positions with increasing stress. The authors have shown that a SiN mask significantly improves physical and optical properties of GaN multilayer systems reducing stress in comparison to samples grown applying the same approaches but without SiN masking layer.

  16. Geometries, stabilities and electronic properties of small-sized Pd2-doped Sin (n = 1-11) clusters

    NASA Astrophysics Data System (ADS)

    Ji, Xiao-Xu; Li, Jing; Wang, Chong; Zhang, Shuai; Lu, Cheng; Li, Gen-Quan

    2015-11-01

    The geometries, growth patterns, relative stabilities and electronic properties of small-sized Pd2Sin and Sin+2 (n = 1-11) clusters are systematically studied using the hybrid density functional theory method B3LYP. The optimised structures revealed that the lowest energy Pd2Sin clusters are not similar to those of pure Sin clusters. When n = 9, one Pd atom in Pd2Si9 completely falls into the centre of the Si outer frame, forming metal-encapsulated Si cages. On the basis of the optimised structures, the averaged binding energy, fragmentation energy, second-order energy difference and highest occupied-lowest unoccupied molecular orbital energy gap are calculated. It is found that the Pd2Si5 and Pd2Si7 clusters have stronger relative stabilities among the Pd2Sin clusters. Additionally, the stabilities of Sin+2 clusters have been reduced by the doping of Pd impurity. The natural population and natural electronic configuration analysis indicated that the Pd atoms possess negative charges for n = 1-11 and there exist the spd hybridisation in the Pd atom. Finally, the chemical hardness, chemical potential, electrostatic potential and polarisability are discussed.

  17. Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation

    PubMed Central

    Bainor, Anthony J.; David, Gregory

    2014-01-01

    The Polycomb group protein Bmi-1 is an essential regulator of cellular senescence and is believed to function largely through the direct repression of the Ink4a/Arf locus. However, concurrent deletion of Ink4a/Arf does not fully rescue the defects detected in Bmi-1−/− mice, indicating that additional Bmi-1 targets remain to be identified. The expression of the chromatin associated Sin3B protein is stimulated by oncogenic stress, and is required for oncogene-induced senescence. Here we demonstrate that oncogenic stress leads to the dissociation of Bmi-1 from the Sin3B locus, resulting in increased Sin3B expression and subsequent entry into cellular senescence. Furthermore, Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion. Altogether, these results identify Sin3B as a novel direct target of Bmi-1, and establish Bmi-1-driven repression of Sin3B as an essential regulator of cellular senescence. PMID:25263442

  18. Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39

    PubMed Central

    Faherty, Noel; Benson, Matthew; Sharma, Eshita; Lee, Angela; Howarth, Alison; Lockstone, Helen; Ebner, Daniel; Bhattacharya, Shoumo

    2016-01-01

    BMP signalling is negatively autoregulated by several genes including SMAD6, Noggin and Gremlin, and autoregulators are possible targets for enhancing BMP signalling in disorders such as fibrosis and pulmonary hypertension. To identify novel negative regulators of BMP signalling, we used siRNA screening in mouse C2C12 cells with a BMP-responsive luciferase reporter. Knockdown of several splicing factors increased BMP4-dependent transcription and target gene expression. Knockdown of RBM39 produced the greatest enhancement in BMP activity. Transcriptome-wide RNA sequencing identified a change in Sin3b exon usage after RBM39 knockdown. SIN3B targets histone deacetylases to chromatin to repress transcription. In mouse, Sin3b produces long and short isoforms, with the short isoform lacking the ability to recruit HDACs. BMP4 induced a shift in SIN3B expression to the long isoform, and this change in isoform ratio was prevented by RBM39 knockdown. Knockdown of long isoform SIN3B enhanced BMP4-dependent transcription, whereas knockdown of the short isoform did not. We propose that BMP4-dependent transcription is negatively autoregulated in part by SIN3B alternative splicing, and that RBM39 plays a role in this process. PMID:27324164

  19. An SINS/GNSS Ground Vehicle Gravimetry Test Based on SGA-WZ02

    PubMed Central

    Yu, Ruihang; Cai, Shaokun; Wu, Meiping; Cao, Juliang; Zhang, Kaidong

    2015-01-01

    In March 2015, a ground vehicle gravimetry test was implemented in eastern Changsha to assess the repeatability and accuracy of ground vehicle SINS/GNSS gravimeter—SGA-WZ02. The gravity system developed by NUDT consisted of a Strapdown Inertial Navigation System (SINS), a Global Navigation Satellite System (GNSS) remote station on test vehicle, a GNSS static master station on the ground, and a data logging subsystem. A south-north profile of 35 km along the highway in eastern Changsha was chosen and four repeated available measure lines were obtained. The average speed of a vehicle is 40 km/h. To assess the external ground gravity disturbances, precise ground gravity data was built by CG-5 precise gravimeter as the reference. Under relative smooth conditions, internal accuracy among repeated lines shows an average agreement at the level of 1.86 mGal for half wavelengths about 1.1 km, and 1.22 mGal for 1.7 km. The root-mean-square (RMS) of difference between calculated gravity data and reference data is about 2.27 mGal/1.1 km, and 1.74 mGal/1.7 km. Not all of the noises caused by vehicle itself and experiments environments were eliminated in the primary results. By means of selecting reasonable filters and improving the GNSS observation conditions, further developments in ground vehicle gravimetry are promising. PMID:26389916

  20. An SINS/GNSS Ground Vehicle Gravimetry Test Based on SGA-WZ02.

    PubMed

    Yu, Ruihang; Cai, Shaokun; Wu, Meiping; Cao, Juliang; Zhang, Kaidong

    2015-01-01

    In March 2015, a ground vehicle gravimetry test was implemented in eastern Changsha to assess the repeatability and accuracy of ground vehicle SINS/GNSS gravimeter-SGA-WZ02. The gravity system developed by NUDT consisted of a Strapdown Inertial Navigation System (SINS), a Global Navigation Satellite System (GNSS) remote station on test vehicle, a GNSS static master station on the ground, and a data logging subsystem. A south-north profile of 35 km along the highway in eastern Changsha was chosen and four repeated available measure lines were obtained. The average speed of a vehicle is 40 km/h. To assess the external ground gravity disturbances, precise ground gravity data was built by CG-5 precise gravimeter as the reference. Under relative smooth conditions, internal accuracy among repeated lines shows an average agreement at the level of 1.86 mGal for half wavelengths about 1.1 km, and 1.22 mGal for 1.7 km. The root-mean-square (RMS) of difference between calculated gravity data and reference data is about 2.27 mGal/1.1 km, and 1.74 mGal/1.7 km. Not all of the noises caused by vehicle itself and experiments environments were eliminated in the primary results. By means of selecting reasonable filters and improving the GNSS observation conditions, further developments in ground vehicle gravimetry are promising. PMID:26389916

  1. An SINS/GNSS Ground Vehicle Gravimetry Test Based on SGA-WZ02.

    PubMed

    Yu, Ruihang; Cai, Shaokun; Wu, Meiping; Cao, Juliang; Zhang, Kaidong

    2015-09-16

    In March 2015, a ground vehicle gravimetry test was implemented in eastern Changsha to assess the repeatability and accuracy of ground vehicle SINS/GNSS gravimeter-SGA-WZ02. The gravity system developed by NUDT consisted of a Strapdown Inertial Navigation System (SINS), a Global Navigation Satellite System (GNSS) remote station on test vehicle, a GNSS static master station on the ground, and a data logging subsystem. A south-north profile of 35 km along the highway in eastern Changsha was chosen and four repeated available measure lines were obtained. The average speed of a vehicle is 40 km/h. To assess the external ground gravity disturbances, precise ground gravity data was built by CG-5 precise gravimeter as the reference. Under relative smooth conditions, internal accuracy among repeated lines shows an average agreement at the level of 1.86 mGal for half wavelengths about 1.1 km, and 1.22 mGal for 1.7 km. The root-mean-square (RMS) of difference between calculated gravity data and reference data is about 2.27 mGal/1.1 km, and 1.74 mGal/1.7 km. Not all of the noises caused by vehicle itself and experiments environments were eliminated in the primary results. By means of selecting reasonable filters and improving the GNSS observation conditions, further developments in ground vehicle gravimetry are promising.

  2. Computational study of AuSin (n=1-9) nanoalloy clusters invoking DFT based descriptors

    NASA Astrophysics Data System (ADS)

    Ranjan, Prabhat; Kumar, Ajay; Chakraborty, Tanmoy

    2016-04-01

    Nanoalloy clusters formed between Au and Si are topics of great interest today from both scientific and technological point of view. Due to its remarkable catalytic, electronic, mechanical and magnetic properties Au-Si nanoalloy clusters have extensive applications in the field of microelectronics, catalysis, biomedicine, and jewelry industry. Density Functional Theory (DFT) is a new paradigm of quantum mechanics, which is very much popular to study the electronic properties of materials. Conceptual DFT based descriptors have been invoked to correlate the experimental properties of nanoalloy clusters. In this venture, we have systematically investigated AuSin (n=1-9) nanoalloy clusters in the theoretical frame of the B3LYP exchange correlation. The experimental properties of AuSin (n=1-9) nanoalloy clusters are correlated in terms of DFT based descriptors viz. HOMO-LUMO gap, Electronegativity (χ), Global Hardness (η), Global Softness (S) and Electrophilicity Index (ω). The calculated HOMO-LUMO gap exhibits interesting odd-even alteration behaviour, indicating that even numbered clusters possess higher stability as compare to their neighbour odd numbered clusters. This study also reflects a very well agreement between experimental bond length and computed data.

  3. From Sin to Crime: Laws on Infanticide in the Middle Ages.

    PubMed

    Obladen, Michael

    2016-01-01

    This is the second of three papers investigating the legislative history concerning infanticide. It compares the efforts of various states to protect the newborn infant between 534 and 1532 CE. When the Roman Empire collapsed in the 5th century, the jurisdiction of infanticide was relegated to the church, which regarded carnal delicts a sin rather than a crime. The punishment - public penance of the mother for 7-15 years - was milder than that which the murder of an adult would incur. The Council of Florence decreed in 1439 that the souls of children who died without having been baptized descend to hell. This turned infanticide from a penitential sin to the most heinous of all crimes. The states passed laws that abominated infanticide even more than the murder of older humans and punished women with ever more cruel forms of execution. Towards the men, however, who usually abandoned the women they had impregnated, the laws were lenient. Churches and society continued to vilify illegitimate birth, thus enhancing rather than preventing infanticide. The Habsburg-German legislation of 1532 ordained to torture any woman who had concealed pregnancy and birth and claimed the infant was stillborn. Legislation developed similarly in other countries, albeit at a different speed. French (1556) and British (1623) legislation reversed the burden of proof and demanded the death penalty for concealing pregnancy and birth when a dead infant was found.

  4. Preparation and combustion of coal-water fuel from the Sin Pun coal deposit, southern Thailand

    SciTech Connect

    1997-05-01

    In response to an inquiry by the Department of Mineral Resources in Thailand, the Energy & Environmental Research Center (EERC) prepared a program to assess the responsiveness of Sin Pun lignite to the temperature and pressure conditions of hot-water drying. The results indicate that drying made several improvements in the coal, notably increases in heating value and carbon content and reductions in equilibrium moisture and oxygen content. The equilibrium moisture content decreased from 27 wt% for the raw coal to about 15 wt% for the hot-water-dried (HWD) coals. The energy density for a pumpable coal-water fuel (CWF) indicates an increase from 4500 to 6100 Btu/lb by hot-water drying. Approximately 650 lb of HWD Sin Pun CWF were fired in the EERC`s combustion test facility. The fuel burned extremely well, with no feed problems noted during the course of the test. Fouling and slagging deposits each indicated a very low rate of ash deposition, with only a dusty layer formed on the cooled metal surfaces. The combustor was operated at between 20% and 25% excess air, resulting in a flue gas SO{sub 2} concentration averaging approximately 6500 parts per million.

  5. From Sin to Crime: Laws on Infanticide in the Middle Ages.

    PubMed

    Obladen, Michael

    2016-01-01

    This is the second of three papers investigating the legislative history concerning infanticide. It compares the efforts of various states to protect the newborn infant between 534 and 1532 CE. When the Roman Empire collapsed in the 5th century, the jurisdiction of infanticide was relegated to the church, which regarded carnal delicts a sin rather than a crime. The punishment - public penance of the mother for 7-15 years - was milder than that which the murder of an adult would incur. The Council of Florence decreed in 1439 that the souls of children who died without having been baptized descend to hell. This turned infanticide from a penitential sin to the most heinous of all crimes. The states passed laws that abominated infanticide even more than the murder of older humans and punished women with ever more cruel forms of execution. Towards the men, however, who usually abandoned the women they had impregnated, the laws were lenient. Churches and society continued to vilify illegitimate birth, thus enhancing rather than preventing infanticide. The Habsburg-German legislation of 1532 ordained to torture any woman who had concealed pregnancy and birth and claimed the infant was stillborn. Legislation developed similarly in other countries, albeit at a different speed. French (1556) and British (1623) legislation reversed the burden of proof and demanded the death penalty for concealing pregnancy and birth when a dead infant was found. PMID:26583381

  6. Mutational and functional analysis of dominant SPT2 (SIN1) suppressor alleles in Saccharomyces cerevisiae.

    PubMed Central

    Lefebvre, L; Smith, M

    1993-01-01

    The Saccharomyces cerevisiae SPT2 gene was identified by genetic screens for mutations which are suppressors of Ty and delta insertional mutations at the HIS4 locus. The ability of spt2 mutations to suppress the transcriptional interference caused by the delta promoter insertion his-4-912 delta correlates with an increase in wild-type HIS4 mRNA levels. The SPT2 gene is identical to SIN1, which codes for a factor genetically defined as a negative regulator of HO transcription. Mutations in SPT2/SIN1 suppress the effects of trans-acting mutations in SWI genes and of partial deletions in the C-terminal domain of the largest subunit of RNA polymerase II. Nuclear localization and protein sequence similarities suggested that the SPT2/SIN1 protein may be related to the nonhistone chromosomal protein HMG1. To assess the significance of this structural similarity and identify domains of SPT2 functionally important in the regulation of his4-912 delta, we have studied recessive and dominant spt2 mutations created by in vitro mutagenesis. We show here that several alleles carrying C-terminal deletions as well as point mutations in the C-terminal domain of the SPT2 protein exhibit a dominant suppressor phenotype. C-terminal basic residues necessary for wild-type SPT2 protein function which are absent from HMG1 have been identified. The competence of these mutant SPT2 proteins to interfere with the maintenance of the His- (Spt+) phenotype of a his4-912 delta SPT2+ strain is lost by deletion of internal HMG1-like sequences and is sensitive to the wild-type SPT2+ gene dosage. Using cross-reacting antipeptide polyclonal antibodies, we demonstrate that the intracellular level of the wild-type SPT2 protein is not affected in presence of dominant mutations and furthermore that the reversion of the dominance by internal deletion of HMG1-like sequences is not mediated by altered production or stability of the mutant polypeptides. Our results suggest that the products of dominant alleles

  7. Remote sensing and geographic information systems: charting Sin Nombre virus infections in deer mice.

    PubMed Central

    Boone, J. D.; McGwire, K. C.; Otteson, E. W.; DeBaca, R. S.; Kuhn, E. A.; Villard, P.; Brussard, P. F.; St Jeor, S. C.

    2000-01-01

    We tested environmental data from remote sensing and geographic information system maps as indicators of Sin Nombre virus (SNV) infections in deer mouse (Peromyscus maniculatus) populations in the Walker River Basin, Nevada and California. We determined by serologic testing the presence of SNV infections in deer mice from 144 field sites. We used remote sensing and geographic information systems data to characterize the vegetation type and density, elevation, slope, and hydrologic features of each site. The data retroactively predicted infection status of deer mice with up to 80% accuracy. If models of SNV temporal dynamics can be integrated with baseline spatial models, human risk for infection may be assessed with reasonable accuracy. PMID:10827114

  8. Increased Host Species Diversity and Decreased Prevalence of Sin Nombre Virus

    PubMed Central

    Ruedas, Luis A.

    2009-01-01

    Emerging outbreaks of zoonotic diseases are affecting humans at an alarming rate. Until the ecological factors associated with zoonoses are better understood, disease emergence will continue. For Lyme disease, disease suppression has been demonstrated by a dilution effect, whereby increasing species diversity decreases disease prevalence in host populations. To test the dilution effect in another disease, we examined 17 ecological variables associated with prevalence of the directly transmitted Sin Nombre virus (genus Hantavirus, etiologic agent of hantavirus pulmonary syndrome) in its wildlife host, the deer mouse (Peromyscus maniculatus). Only species diversity was statistically linked to infection prevalence: as species diversity decreased, infection prevalence increased. The increase was moderate, but prevalence increased exponentially at low levels of diversity, a phenomenon described as zoonotic release. The results suggest that species diversity affects disease emergence. PMID:19624913

  9. A Self-Alignment Algorithm for SINS Based on Gravitational Apparent Motion and Sensor Data Denoising

    PubMed Central

    Liu, Yiting; Xu, Xiaosu; Liu, Xixiang; Yao, Yiqing; Wu, Liang; Sun, Jin

    2015-01-01

    Initial alignment is always a key topic and difficult to achieve in an inertial navigation system (INS). In this paper a novel self-initial alignment algorithm is proposed using gravitational apparent motion vectors at three different moments and vector-operation. Simulation and analysis showed that this method easily suffers from the random noise contained in accelerometer measurements which are used to construct apparent motion directly. Aiming to resolve this problem, an online sensor data denoising method based on a Kalman filter is proposed and a novel reconstruction method for apparent motion is designed to avoid the collinearity among vectors participating in the alignment solution. Simulation, turntable tests and vehicle tests indicate that the proposed alignment algorithm can fulfill initial alignment of strapdown INS (SINS) under both static and swinging conditions. The accuracy can either reach or approach the theoretical values determined by sensor precision under static or swinging conditions. PMID:25923932

  10. A Self-Alignment Algorithm for SINS Based on Gravitational Apparent Motion and Sensor Data Denoising.

    PubMed

    Liu, Yiting; Xu, Xiaosu; Liu, Xixiang; Yao, Yiqing; Wu, Liang; Sun, Jin

    2015-01-01

    Initial alignment is always a key topic and difficult to achieve in an inertial navigation system (INS). In this paper a novel self-initial alignment algorithm is proposed using gravitational apparent motion vectors at three different moments and vector-operation. Simulation and analysis showed that this method easily suffers from the random noise contained in accelerometer measurements which are used to construct apparent motion directly. Aiming to resolve this problem, an online sensor data denoising method based on a Kalman filter is proposed and a novel reconstruction method for apparent motion is designed to avoid the collinearity among vectors participating in the alignment solution. Simulation, turntable tests and vehicle tests indicate that the proposed alignment algorithm can fulfill initial alignment of strapdown INS (SINS) under both static and swinging conditions. The accuracy can either reach or approach the theoretical values determined by sensor precision under static or swinging conditions. PMID:25923932

  11. Responding to the second ghetto: Chicago's Joe Smith and Sin Corner.

    PubMed

    Pacyga, Dominic A

    2011-01-01

    World War Two and its aftermath transformed Chicago's African American community. The Great Migration entered a second and more intense phase as black migrants flooded into Northern cities. This massive relocation of Southern blacks resulted in the expansion and reformulation of Chicago's ghettoes on both the West and South Sides of the city. The question of a response to this Second Ghetto from African Americans themselves presents itself. White politicians, cultural elites and businessmen still controlled the city and could impose their will on its neighborhoods simply redrawing ghetto boundaries to reflect the new realities of the postwar era. The strange case of Joe Smith and Sin Corner sheds some light on black agency in the 1950s. The African American middle class had resources it commanded to try and protect itself from racial injustice. These resources, however, were based on class privileges not enjoyed by most in the African American community. PMID:21158199

  12. Optimization of a bolometer detector for ITER based on Pt absorber on SiN membrane

    SciTech Connect

    Meister, H.; Eich, T.; Endstrasser, N.; Giannone, L.; Kannamueller, M.; Kling, A.; Koll, J.; Trautmann, T.; Detemple, P.; Schmitt, S.; Collaboration: ASDEX Upgrade Team

    2010-10-15

    Any plasma diagnostic in ITER must be able to operate at temperatures in excess of 200 deg. C and neutron loads corresponding to 0.1 dpa over its lifetime. To achieve this aim for the bolometer diagnostic, a miniaturized metal resistor bolometer detector based on Pt absorbers galvanically deposited on SiN membranes is being developed. The first two generations of detectors featured up to 4.5 {mu}m thick absorbers. Results from laboratory tests are presented characterizing the dependence of their calibration constants under thermal loads up to 450 deg. C. Several detectors have been tested in ASDEX Upgrade providing reliable data but also pointing out the need for further optimization. A laser trimming procedure has been implemented to reduce the mismatch in meander resistances below 1% for one detector and the thermal drifts from this mismatch.

  13. Optimization of a bolometer detector for ITER based on Pt absorber on SiN membrane.

    PubMed

    Meister, H; Eich, T; Endstrasser, N; Giannone, L; Kannamüller, M; Kling, A; Koll, J; Trautmann, T; Detemple, P; Schmitt, S

    2010-10-01

    Any plasma diagnostic in ITER must be able to operate at temperatures in excess of 200 °C and neutron loads corresponding to 0.1 dpa over its lifetime. To achieve this aim for the bolometer diagnostic, a miniaturized metal resistor bolometer detector based on Pt absorbers galvanically deposited on SiN membranes is being developed. The first two generations of detectors featured up to 4.5 μm thick absorbers. Results from laboratory tests are presented characterizing the dependence of their calibration constants under thermal loads up to 450 °C. Several detectors have been tested in ASDEX Upgrade providing reliable data but also pointing out the need for further optimization. A laser trimming procedure has been implemented to reduce the mismatch in meander resistances below 1% for one detector and the thermal drifts from this mismatch.

  14. Precision measurement of sin/sup 2/theta/sub W/ from semileptonic neutrino scattering

    SciTech Connect

    Abramowicz, H.; Belusevic, R.; Blondel, A.; Bluemer, H.; Boeckmann, P.; Brummel, H.D.; Buchholz, P.; Burkhardt, H.; Debu, P.; Duda, J.; Dydak, F.; Falkenburg, B.; Fiedler, M.; Geiges, R.; Geweniger, C.; Grant, A.L.; Guyot, C.; Hagelberg, R.; Hepp, V.; Hughes, E.W.; Kampschulte, B.; Keilwerth, H.; Kleinknecht, K.; Knobloch, J.; Krasny, M.; Kro-acute-accentlikowski, J.; Kurz, N.; Lipniacka, A.; Merlo, J.; Mueller, E.; Para, A.; Perez, P.; Perrier, F.; Pollman, D.; Ranjard, F.; Renk, B.; Schuller, J.; Taureg, H.; Tittel, K.; Turlay, R.; Vallage, B.; Wachsmuth, H.; Wotschack, J.

    1986-07-21

    The ratio R-italic/sub ..nu../ of the neutral- to charged-current cross sections of neutrinos in iron has been measured in an exposure of the CERN-Dortmund-Heidelberg-Saclay neutrino detector to a 160-GeV/c-italic neutrino narrow-band beam at the CERN Super Proton Synchrotron. The result is R-italic/sub ..nu../ = 0.3072 +- 0.0025(stat) +- 0.0020(syst), for hadronic energy greater than 10 GeV. The electroweak mixing parameter is sin/sup 2/theta/sub W/ = 0.225 +- 0.005(expt ) +- 0.003(theor)+0.013(m-italic/sub c-italic/-1. 5 GeV/c-italic/sup 2/), where m-italic/sub c-italic/ is the charm-quark mass.

  15. A Novel Robust H∞ Filter Based on Krein Space Theory in the SINS/CNS Attitude Reference System.

    PubMed

    Yu, Fei; Lv, Chongyang; Dong, Qianhui

    2016-01-01

    Owing to their numerous merits, such as compact, autonomous and independence, the strapdown inertial navigation system (SINS) and celestial navigation system (CNS) can be used in marine applications. What is more, due to the complementary navigation information obtained from two different kinds of sensors, the accuracy of the SINS/CNS integrated navigation system can be enhanced availably. Thus, the SINS/CNS system is widely used in the marine navigation field. However, the CNS is easily interfered with by the surroundings, which will lead to the output being discontinuous. Thus, the uncertainty problem caused by the lost measurement will reduce the system accuracy. In this paper, a robust H∞ filter based on the Krein space theory is proposed. The Krein space theory is introduced firstly, and then, the linear state and observation models of the SINS/CNS integrated navigation system are established reasonably. By taking the uncertainty problem into account, in this paper, a new robust H∞ filter is proposed to improve the robustness of the integrated system. At last, this new robust filter based on the Krein space theory is estimated by numerical simulations and actual experiments. Additionally, the simulation and experiment results and analysis show that the attitude errors can be reduced by utilizing the proposed robust filter effectively when the measurements are missing discontinuous. Compared to the traditional Kalman filter (KF) method, the accuracy of the SINS/CNS integrated system is improved, verifying the robustness and the availability of the proposed robust H∞ filter. PMID:26999153

  16. A Feasibility Analysis of Land-Based SINS/GNSS Gravimetry for Groundwater Resource Detection in Taiwan.

    PubMed

    Chiang, Kai-Wei; Lin, Cheng-An; Kuo, Chung-Yen

    2015-01-01

    The integration of the Strapdown Inertial Navigation System and Global Navigation Satellite System (SINS/GNSS) has been implemented for land-based gravimetry and has been proven to perform well in estimating gravity. Based on the mGal-level gravimetry results, this research aims to construct and develop a land-based SINS/GNSS gravimetry device containing a navigation-grade Inertial Measurement Unit. This research also presents a feasibility analysis for groundwater resource detection. A preliminary comparison of the kinematic velocities and accelerations using multi-combination of GNSS data including Global Positioning System, Global Navigation Satellite System, and BeiDou Navigation Satellite System, indicates that three-system observations performed better than two-system data in the computation. A comparison of gravity derived from SINS/GNSS and measured using a relative gravimeter also shows that both agree reasonably well with a mean difference of 2.30 mGal. The mean difference between repeat measurements of gravity disturbance using SINS/GNSS is 2.46 mGal with a standard deviation of 1.32 mGal. The gravity variation because of the groundwater at Pingtung Plain, Taiwan could reach 2.72 mGal. Hence, the developed land-based SINS/GNSS gravimetry can sufficiently and effectively detect groundwater resources. PMID:26426019

  17. A Feasibility Analysis of Land-Based SINS/GNSS Gravimetry for Groundwater Resource Detection in Taiwan.

    PubMed

    Chiang, Kai-Wei; Lin, Cheng-An; Kuo, Chung-Yen

    2015-09-29

    The integration of the Strapdown Inertial Navigation System and Global Navigation Satellite System (SINS/GNSS) has been implemented for land-based gravimetry and has been proven to perform well in estimating gravity. Based on the mGal-level gravimetry results, this research aims to construct and develop a land-based SINS/GNSS gravimetry device containing a navigation-grade Inertial Measurement Unit. This research also presents a feasibility analysis for groundwater resource detection. A preliminary comparison of the kinematic velocities and accelerations using multi-combination of GNSS data including Global Positioning System, Global Navigation Satellite System, and BeiDou Navigation Satellite System, indicates that three-system observations performed better than two-system data in the computation. A comparison of gravity derived from SINS/GNSS and measured using a relative gravimeter also shows that both agree reasonably well with a mean difference of 2.30 mGal. The mean difference between repeat measurements of gravity disturbance using SINS/GNSS is 2.46 mGal with a standard deviation of 1.32 mGal. The gravity variation because of the groundwater at Pingtung Plain, Taiwan could reach 2.72 mGal. Hence, the developed land-based SINS/GNSS gravimetry can sufficiently and effectively detect groundwater resources.

  18. A Feasibility Analysis of Land-Based SINS/GNSS Gravimetry for Groundwater Resource Detection in Taiwan

    PubMed Central

    Chiang, Kai-Wei; Lin, Cheng-An; Kuo, Chung-Yen

    2015-01-01

    The integration of the Strapdown Inertial Navigation System and Global Navigation Satellite System (SINS/GNSS) has been implemented for land-based gravimetry and has been proven to perform well in estimating gravity. Based on the mGal-level gravimetry results, this research aims to construct and develop a land-based SINS/GNSS gravimetry device containing a navigation-grade Inertial Measurement Unit. This research also presents a feasibility analysis for groundwater resource detection. A preliminary comparison of the kinematic velocities and accelerations using multi-combination of GNSS data including Global Positioning System, Global Navigation Satellite System, and BeiDou Navigation Satellite System, indicates that three-system observations performed better than two-system data in the computation. A comparison of gravity derived from SINS/GNSS and measured using a relative gravimeter also shows that both agree reasonably well with a mean difference of 2.30 mGal. The mean difference between repeat measurements of gravity disturbance using SINS/GNSS is 2.46 mGal with a standard deviation of 1.32 mGal. The gravity variation because of the groundwater at Pingtung Plain, Taiwan could reach 2.72 mGal. Hence, the developed land-based SINS/GNSS gravimetry can sufficiently and effectively detect groundwater resources. PMID:26426019

  19. [Control levels of Sin3 histone deacetylase for spontaneous and UV-induced mutagenesis in yeasts Saccharomyces cerevisiae].

    PubMed

    Lebovka, I Iu; Kozhina, T N; Fedorova, I V; Peshekhonov, V T; Evstiukhina, T A; Chernenkov, A Iu; Korolev, V G

    2014-01-01

    SIN3 gene product operates as a repressor for a huge amount of genes in Saccharomyces cerevisiae. Sin3 protein with a mass of about 175 kDa is a member of the RPD3 protein complex with an assessed mass of greater than 2 million Da. It was previously shownthat RPD3 gene mutations influence recombination and repair processes in S. cerevisiae yeasts. We studied the impacts of the sin3 mutation on UV-light sensitivity and UV-induced mutagenesis in budding yeast cells. The deletion ofthe SIN3 gene causes weak UV-sensitivity of mutant budding cells as compared to the wild-type strain. These results show that the sin3 mutation decreases both spontaneous and UV-induced levels of levels. This fact is hypothetically related to themalfunction of ribonucleotide reductase activity regulation, which leads to a decrease in the dNTP pool and the inaccurate error-prone damage bypass postreplication repair pathway, which in turn provokes a reduction in the incidence of mutations.

  20. A Novel Robust H∞ Filter Based on Krein Space Theory in the SINS/CNS Attitude Reference System

    PubMed Central

    Yu, Fei; Lv, Chongyang; Dong, Qianhui

    2016-01-01

    Owing to their numerous merits, such as compact, autonomous and independence, the strapdown inertial navigation system (SINS) and celestial navigation system (CNS) can be used in marine applications. What is more, due to the complementary navigation information obtained from two different kinds of sensors, the accuracy of the SINS/CNS integrated navigation system can be enhanced availably. Thus, the SINS/CNS system is widely used in the marine navigation field. However, the CNS is easily interfered with by the surroundings, which will lead to the output being discontinuous. Thus, the uncertainty problem caused by the lost measurement will reduce the system accuracy. In this paper, a robust H∞ filter based on the Krein space theory is proposed. The Krein space theory is introduced firstly, and then, the linear state and observation models of the SINS/CNS integrated navigation system are established reasonably. By taking the uncertainty problem into account, in this paper, a new robust H∞ filter is proposed to improve the robustness of the integrated system. At last, this new robust filter based on the Krein space theory is estimated by numerical simulations and actual experiments. Additionally, the simulation and experiment results and analysis show that the attitude errors can be reduced by utilizing the proposed robust filter effectively when the measurements are missing discontinuous. Compared to the traditional Kalman filter (KF) method, the accuracy of the SINS/CNS integrated system is improved, verifying the robustness and the availability of the proposed robust H∞ filter. PMID:26999153

  1. A Novel Robust H∞ Filter Based on Krein Space Theory in the SINS/CNS Attitude Reference System.

    PubMed

    Yu, Fei; Lv, Chongyang; Dong, Qianhui

    2016-03-18

    Owing to their numerous merits, such as compact, autonomous and independence, the strapdown inertial navigation system (SINS) and celestial navigation system (CNS) can be used in marine applications. What is more, due to the complementary navigation information obtained from two different kinds of sensors, the accuracy of the SINS/CNS integrated navigation system can be enhanced availably. Thus, the SINS/CNS system is widely used in the marine navigation field. However, the CNS is easily interfered with by the surroundings, which will lead to the output being discontinuous. Thus, the uncertainty problem caused by the lost measurement will reduce the system accuracy. In this paper, a robust H∞ filter based on the Krein space theory is proposed. The Krein space theory is introduced firstly, and then, the linear state and observation models of the SINS/CNS integrated navigation system are established reasonably. By taking the uncertainty problem into account, in this paper, a new robust H∞ filter is proposed to improve the robustness of the integrated system. At last, this new robust filter based on the Krein space theory is estimated by numerical simulations and actual experiments. Additionally, the simulation and experiment results and analysis show that the attitude errors can be reduced by utilizing the proposed robust filter effectively when the measurements are missing discontinuous. Compared to the traditional Kalman filter (KF) method, the accuracy of the SINS/CNS integrated system is improved, verifying the robustness and the availability of the proposed robust H∞ filter.

  2. A density functional study of small sized silver-doped silicon clusters: Ag2Sin (n = 1-13)

    NASA Astrophysics Data System (ADS)

    Yang, Cai; Hao Jia, Song; Ma, Mao Fen; Zhang, Shuai; Lu, Cheng; Li, Gen Quan

    2015-11-01

    The structures and electronic properties for global minimum geometric structures of small-sized neutral Ag2Sin (n = 1-13) clusters have been investigated using the CALYPSO structure searching method coupled with density functional theory calculations. A great deal of low-energy geometric isomers are optimised at the B3LYP / GENECP theory level. The optimised structures suggest that the ground state Ag2Sin clusters are visibly distorted compared with the corresponding pure silicon clusters and favor a three-dimensional configuration. Starting with Ag2Si12, one Ag atom is fully encapsulated by the Si outer cages. Based on the averaged binding energy, fragmentation energy, second-order energy difference and HOMO-LUMO energy gap, it is seen that Ag2Si2 and Ag2Si5 are tested to be the most stable clusters, and the chemical stabilities of pure Sin+2 clusters can be reduced to some extent after doping two Ag atoms. Additionally, natural population and natural electronic configuration are discussed and the results reveal that charges transfer from the Ag atoms to the silicon frames and the spd hybridisations are present in all Ag2Sin clusters. Lastly, the results of natural bonds show that the Ag-Si bond in Ag2Sin clusters is dominated by small ionic character. Supplementary material in the form of one pdf file available from the Journal web page at http://dx.doi.org/10.1140/epjd/e2015-60404-1

  3. Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex.

    PubMed

    Lam, Eric; Pareek, Tej K; Letterio, John J

    2015-01-01

    Cyclin-dependent kinase 5 (Cdk5) is a unique member of a family of serine/threonine cyclin-dependent protein kinases. We previously demonstrated disruption of Cdk5 gene expression in mice impairs T-cell function and ameliorates T-cell-mediated neuroinflammation. Here, we show Cdk5 modulates gene expression during T-cell activation by impairing the repression of gene transcription by histone deacetylase 1 (HDAC1) through specific phosphorylation of the mSin3a protein at serine residue 861. Disruption of Cdk5 activity in T-cells enhances HDAC activity and binding of the HDAC1/mSin3a complex to the IL-2 promoter, leading to suppression of IL-2 gene expression. These data point to essential roles for Cdk5 in regulating gene expression in T-cells and transcriptional regulation by the co-repressor mSin3a. PMID:25785643

  4. Predicting the sin ϕS transverse single-spin asymmetry of pion production at an electron ion collider

    NASA Astrophysics Data System (ADS)

    Wang, Xiaoyu; Lu, Zhun

    2016-04-01

    We study the transverse single-spin asymmetry with a sin ϕS modulation in semi-inclusive deep inelastic scattering. In particular, we consider the case in which the transverse momentum of the final state hadron is integrated out. Thus, the asymmetry is merely contributed by the coupling of the transversity distribution function h1(x ) and the twist-3 collinear fragmentation function H ˜(z ). Using the available parametrization of h1(x ) from SIDIS data and the recent extracted result for H ˜(z ), we predict the sin ϕS asymmetry for charged and neutral pion production at an electron ion collider. We find that the asymmetry is sizable and could be measured. We also study the impact of the leading-order QCD evolution effect and find that it affects the sin ϕS asymmetry at an electron ion collider considerably.

  5. MiR-210 Up-Regulation Inhibits Proliferation and Induces Apoptosis in Glioma Cells by Targeting SIN3A

    PubMed Central

    Shang, Chao; Hong, Yang; Guo, Yan; Liu, Yun-hui; Xue, Yi-xue

    2014-01-01

    Background The aim of this study was to determine whether miR-210 can affect the apoptosis and proliferation of human U251 glioma cells from down-regulating SIN3A. Material/Methods The expression of miRNA-210 was detected by quantitative real-time PCR in normal brain tissue and glioma samples. The apoptosis and proliferation ability of U251 cells were analyzed by MTT and flow cytometry assay after anti-miR-210 transfection. For the regulation mechanism analysis of miR-210, TargetScan, PicTar, and microRNA were selected to predict some potential target genes of miR-210. The predicted gene was identified to be the direct and specific target gene of miR-210 by luciferase activities assay and Western blot. RNA interference technology was used to confirm that the apoptosis and proliferation effects of miR-210 were directly induced by SIN3A. Results The expression of miR-210 increased significantly in glioma in comparison with normal brain tissue. The silence of miR-210 expression could inhibit the proliferation of U251 cells and induce the apoptosis. Mechanism analysis revealed that SIN3A was a specific and direct target gene of miR-210. The siRNA-SIN3A could down-regulate the expression of SIN3A protein, which was up-regulated in U251 cells by anti-miR-210 transfection, and our experiments found that silence of SIN3A could inhibit the apoptosis and sharply increase the proliferation of U251 cells. The regulation effects of anti-miR-210 on apoptosis and proliferation can be reversed respectively by the expression silence of SIN3A. Conclusions Aberrantly expressed miR-210 regulates human U251 glioma cells apoptosis and proliferation partly through directly down-regulating SIN3A protein expression. This might offer a new potential therapeutic stratagem for glioma. PMID:25481483

  6. Differential Lymphocyte and Antibody Responses in Deer Mice Infected with Sin Nombre Hantavirus or Andes Hantavirus

    PubMed Central

    Quackenbush, Sandra; Rovnak, Joel; Haddock, Elaine; Black, William C.; Feldmann, Heinz; Prescott, Joseph

    2014-01-01

    ABSTRACT Hantavirus cardiopulmonary syndrome (HCPS) is a rodent-borne disease with a high case-fatality rate that is caused by several New World hantaviruses. Each pathogenic hantavirus is naturally hosted by a principal rodent species without conspicuous disease and infection is persistent, perhaps for life. Deer mice (Peromyscus maniculatus) are the natural reservoirs of Sin Nombre virus (SNV), the etiologic agent of most HCPS cases in North America. Deer mice remain infected despite a helper T cell response that leads to high-titer neutralizing antibodies. Deer mice are also susceptible to Andes hantavirus (ANDV), which causes most HCPS cases in South America; however, deer mice clear ANDV. We infected deer mice with SNV or ANDV to identify differences in host responses that might account for this differential outcome. SNV RNA levels were higher in the lungs but not different in the heart, spleen, or kidneys. Most ANDV-infected deer mice had seroconverted 14 days after inoculation, but none of the SNV-infected deer mice had. Examination of lymph node cell antigen recall responses identified elevated immune gene expression in deer mice infected with ANDV and suggested maturation toward a Th2 or T follicular helper phenotype in some ANDV-infected deer mice, including activation of the interleukin 4 (IL-4) pathway in T cells and B cells. These data suggest that the rate of maturation of the immune response is substantially higher and of greater magnitude during ANDV infection, and these differences may account for clearance of ANDV and persistence of SNV. IMPORTANCE Hantaviruses persistently infect their reservoir rodent hosts without pathology. It is unknown how these viruses evade sterilizing immune responses in the reservoirs. We have determined that infection of the deer mouse with its homologous hantavirus, Sin Nombre virus, results in low levels of immune gene expression in antigen-stimulated lymph node cells and a poor antibody response. However, infection

  7. Rotation-Activity Correlations in K and M Dwarfs. I. Stellar Parameters and Compilations of v sin i and P/sin i for a Large Sample of Late-K and M Dwarfs

    NASA Astrophysics Data System (ADS)

    Houdebine, E. R.; Mullan, D. J.; Paletou, F.; Gebran, M.

    2016-05-01

    The reliable determination of rotation-activity correlations (RACs) depends on precise measurements of the following stellar parameters: T eff, parallax, radius, metallicity, and rotational speed v sin i. In this paper, our goal is to focus on the determination of these parameters for a sample of K and M dwarfs. In a future paper (Paper II), we will combine our rotational data with activity data in order to construct RACs. Here, we report on a determination of effective temperatures based on the (R-I) C color from the calibrations of Mann et al. and Kenyon & Hartmann for four samples of late-K, dM2, dM3, and dM4 stars. We also determine stellar parameters (T eff, log(g), and [M/H]) using the principal component analysis-based inversion technique for a sample of 105 late-K dwarfs. We compile all effective temperatures from the literature for this sample. We determine empirical radius-[M/H] correlations in our stellar samples. This allows us to propose new effective temperatures, stellar radii, and metallicities for a large sample of 612 late-K and M dwarfs. Our mean radii agree well with those of Boyajian et al. We analyze HARPS and SOPHIE spectra of 105 late-K dwarfs, and we have detected v sin i in 92 stars. In combination with our previous v sin i measurements in M and K dwarfs, we now derive P/sin i measures for a sample of 418 K and M dwarfs. We investigate the distributions of P/sin i, and we show that they are different from one spectral subtype to another at a 99.9% confidence level. Based on observations available at Observatoire de Haute Provence and the European Southern Observatory databases and on Hipparcos parallax measurements.

  8. Elevated Cytokines, Thrombin and PAI-1 in Severe HCPS Patients Due to Sin Nombre Virus

    PubMed Central

    Bondu, Virginie; Schrader, Ron; Gawinowicz, Mary Ann; McGuire, Paul; Lawrence, Daniel A.; Hjelle, Brian; Buranda, Tione

    2015-01-01

    Sin Nombre Hantavirus (SNV, Bunyaviridae Hantavirus) is a Category A pathogen that causes Hantavirus Cardiopulmonary Syndrome (HCPS) with case fatality ratios generally ranging from 30% to 50%. HCPS is characterized by vascular leakage due to dysregulation of the endothelial barrier function. The loss of vascular integrity results in non-cardiogenic pulmonary edema, shock, multi-organ failure and death. Using Electric Cell-substrate Impedance Sensing (ECIS) measurements, we found that plasma samples drawn from University of New Mexico Hospital patients with serologically-confirmed HCPS, induce loss of cell-cell adhesion in confluent epithelial and endothelial cell monolayers grown in ECIS cultureware. We show that the loss of cell-cell adhesion is sensitive to both thrombin and plasmin inhibitors in mild cases, and to thrombin only inhibition in severe cases, suggesting an increasing prothrombotic state with disease severity. A proteomic profile (2D gel electrophoresis and mass spectrometry) of HCPS plasma samples in our cohort revealed robust antifibrinolytic activity among terminal case patients. The prothrombotic activity is highlighted by acute ≥30 to >100 fold increases in active plasminogen activator inhibitor (PAI-1) which, preceded death of the subjects within 48 h. Taken together, this suggests that PAI-1 might be a response to the severe pathology as it is expected to reduce plasmin activity and possibly thrombin activity in the terminal patients. PMID:25674766

  9. Stigmatisation and commercialisation of abortion services in Poland: turning sin into gold.

    PubMed

    Chełstowska, Agata

    2011-05-01

    This paper is about the economic consequences of the stigmatisation and illegality of abortion and its almost complete removal from public health services in Poland since the late 1980s. Once abortion left the public sphere, it entered the grey zone of private arrangements, in which a woman's private worries became someone else's private gain, and her sin turned into gold. The most important consequence was social inequality, as the right to health, life, information and safety became commodities on the free market. Women with money, who are more likely to have political influence, find this bearable, while working class women lack the political capital to protest. In the private sector, there are no government controls on price, quality of care or accountability, and almost no prosecutions. With an estimated 150,000 abortions per year, a rough estimate of US$ 95 million is being generated annually for doctors, unregistered and tax-free. Thus, the combined forces of right-wing ideology and neoliberal economic reforms have created reproductive and social injustice. To address this, stigmatisation of abortion must be countered. But a change in the political climate, a less restrictive interpretation of the law, or even a new law would not resolve the problem. Given reductions in public health care spending, abortion would remain excluded from state coverage unless neoliberal health care reforms could be reversed. PMID:21555090

  10. Smokers’ Strategic Responses to Sin Taxes: Evidence from Panel Data in Thailand

    PubMed Central

    White, Justin S.; Ross, Hana

    2014-01-01

    In addition to quitting and cutting consumption, smokers faced with higher cigarette prices may compensate in several ways that mute the health impact of cigarette taxes. This study examines three price avoidance strategies among adult male smokers in Thailand: trading down to a lower-priced brand, buying individual sticks of cigarettes instead of packs, and substituting roll-your-own (RYO) tobacco for factory-manufactured cigarettes. Using two panels of microlevel data from the International Tobacco Control Southeast Asia Study, collected in 2005 and 2006, we estimate the effects of a substantial excise tax increase implemented throughout Thailand in December 2005. We present estimates of the marginal effects and price elasticities for each of five consumer behaviors. We find that, controlling for baseline smoking characteristics, socio-demographics, and policy variables, quitting is highly sensitive to changes in cigarette prices, but so are brand choice, stick-buying, and use of RYO tobacco. Neglecting such strategic responses leads to over-estimates of a sin tax’s health impact, and neglecting product substitution distorts estimates of the price elasticity of cigarette demand. We discuss the implications for consumer welfare and several policies that mitigate the adverse impact of consumer responses. PMID:24677731

  11. Smokers' strategic responses to sin taxes: evidence from panel data in Thailand.

    PubMed

    White, Justin S; Ross, Hana

    2015-02-01

    In addition to quitting and cutting consumption, smokers faced with higher cigarette prices may compensate in several ways that mute the health impact of cigarette taxes. This study examines three price avoidance strategies among adult male smokers in Thailand: trading down to a lower-priced brand, buying individual sticks of cigarettes instead of packs, and substituting roll-your-own tobacco for factory-manufactured cigarettes. Using two panels of microlevel data from the International Tobacco Control Southeast Asia Study, collected in 2005 and 2006, we estimate the effects of a substantial excise tax increase implemented throughout Thailand in December 2005. We present estimates of the marginal effects and price elasticities for each of five consumer behaviors. We find that, controlling for baseline smoking characteristics, sociodemographics, and policy variables, quitting is highly sensitive to changes in cigarette prices, but so are brand choice, stick-buying, and use of roll-your-own tobacco. Neglecting such strategic responses leads to overestimates of a sin tax's health impact, and neglecting product substitution distorts estimates of the price elasticity of cigarette demand. We discuss the implications for consumer welfare and several policies that mitigate the adverse impact of consumer responses.

  12. Optimization Algorithm for Kalman Filter Exploiting the Numerical Characteristics of SINS/GPS Integrated Navigation Systems

    PubMed Central

    Hu, Shaoxing; Xu, Shike; Wang, Duhu; Zhang, Aiwu

    2015-01-01

    Aiming at addressing the problem of high computational cost of the traditional Kalman filter in SINS/GPS, a practical optimization algorithm with offline-derivation and parallel processing methods based on the numerical characteristics of the system is presented in this paper. The algorithm exploits the sparseness and/or symmetry of matrices to simplify the computational procedure. Thus plenty of invalid operations can be avoided by offline derivation using a block matrix technique. For enhanced efficiency, a new parallel computational mechanism is established by subdividing and restructuring calculation processes after analyzing the extracted “useful” data. As a result, the algorithm saves about 90% of the CPU processing time and 66% of the memory usage needed in a classical Kalman filter. Meanwhile, the method as a numerical approach needs no precise-loss transformation/approximation of system modules and the accuracy suffers little in comparison with the filter before computational optimization. Furthermore, since no complicated matrix theories are needed, the algorithm can be easily transplanted into other modified filters as a secondary optimization method to achieve further efficiency. PMID:26569247

  13. RESOLVING THE sin(I) DEGENERACY IN LOW-MASS MULTI-PLANET SYSTEMS

    SciTech Connect

    Batygin, Konstantin; Laughlin, Gregory

    2011-04-01

    Long-term orbital evolution of multi-planet systems under tidal dissipation often converges to a stationary state, known as the tidal fixed point. The fixed point is characterized by a lack of oscillations in the eccentricities and apsidal alignment among the orbits. Quantitatively, the nature of the fixed point is dictated by mutual interactions among the planets as well as non-Keplerian effects. We show that if a roughly coplanar system hosts a hot, sub-Saturn mass planet, and is tidally relaxed, separation of planet-planet interactions and non-Keplerian effects in the equations of motion leads to a direct determination of the true masses of the planets. Consequently, a 'snap-shot' observational determination of the orbital state resolves the sin(I) degeneracy and opens up a direct avenue toward identification of the true lowest-mass exoplanets detected. We present an approximate, as well as a general, mathematical framework for computation of the line-of-sight inclination of secular systems, and apply our models illustratively to the 61 Vir system. We conclude by discussing the observability of planetary systems to which our method is applicable and we set our analysis into a broader context by presenting a current summary of the various possibilities for determining the physical properties of planets from observations of their orbital states.

  14. How might global health master deadly sins and strive for greater virtues?

    PubMed Central

    Panter-Brick, Catherine; Eggerman, Mark; Tomlinson, Mark

    2014-01-01

    In the spirit of critical reflection, we examine how the field of global health might surmount current challenges and prioritize its ethical mandate, namely to achieve, for all people, equity in health. We use the parlance of mastering deadly sins and striving for greater virtues in an effort to review what is needed to transform global health action. Global health falls prey to four main temptations: coveting silo gains, lusting for technological solutions, leaving broad promises largely unfulfilled, and boasting of narrow successes. This necessitates a change of heart: to keep faith with the promise it made, global health requires a realignment of core values and a sharper focus on the primacy of relationships with the communities it serves. Based on the literature to date, we highlight six steps to re-orienting global health action. Articulating a coherent global health agenda will come from principled action, enacted through courage and prudence in decision-making to foster people-centered systems of care over the entire lifespan. PMID:24685169

  15. Epidemiology, symptoms and treatment of paragonimiasis in Sin Ho district, Lai Chau province, Vietnam.

    PubMed

    De, N V; Cong, L D; Kino, H; Son, D T; Vien, H V

    2000-01-01

    Sin Ho is a district of the northern mountainous province of Lai Chau, Vietnam, where the people have the habit of eating undercooked crabs. A study on paragoniamiasis carried out from 1994 to 1995 with 1,642 persons in this endemic area, showed that the rate of eating raw-crab was 72.5%. Crab examination (Ranguna kimboiensis) showed an infection rate of Paragonimus metacercaria of 98.1%. With 624 stool samples examined by Kato technique, the infection rate of Paragonimus in humans was 6.4%. With 338 sputum samples examined by direct and centrifuge methods, the infection rate of Paragonimus was 7.4%. Most of the patients were children (63.2%). The infection rate of Paragonimus in dogs was 18.2 - 33.3%. Adult worms, collected from the dogs in the field and from the cats in laboratory, were identified as Paragonimus heterotremus. The main symptoms of Paragonimus patients were cough and hemoptysis (92%), discontinuously developed (96%), without fever (94%), chest pain (70%), pleural effusion (26%), neurogical symptoms (8%), eosinophilia (88.9%), nodular ring shadows in the lungs, as shown by chest X-ray examination and more in lower lobe, (76.2%). Paragonimiasis patients were treated by (a) Praziquantel 25 mg/kg/day x 3 days; the cure rate was 68.8%. (b) Praziquantel 50 mg/kg/day x 3 days; the cure rate was 75%. PMID:11414455

  16. Kinetics of Immune Responses in Deer Mice Experimentally Infected with Sin Nombre Virus

    PubMed Central

    Acuña-Retamar, Mariana; Feinstein, Shira; Prescott, Joseph; Torres-Perez, Fernando; Podell, Brendan; Peters, Staci; Ye, Chunyan; Black, William C.; Hjelle, Brian

    2012-01-01

    Deer mice are the principal reservoir hosts of Sin Nombre virus, the etiologic agent of most hantavirus cardiopulmonary syndrome cases in North America. Infection of deer mice results in persistence without conspicuous pathology, and most, if not all, infected mice remain infected for life, with periods of viral shedding. The kinetics of viral load, histopathology, virus distribution, and immune gene expression in deer mice were examined. Viral antigen was detected as early as 5 days postinfection and peaked on day 15 in the lungs, hearts, kidneys, and livers. Viral RNA levels varied substantially but peaked on day 15 in the lungs and heart, and antinucleocapsid IgG antibodies appeared in some animals on day 10, but a strong neutralizing antibody response failed to develop during the 20-day experiment. No clinical signs of disease were observed in any of the infected deer mice. Most genes were repressed on day 2, suggesting a typical early downregulation of gene expression often observed in viral infections. Several chemokine and cytokine genes were elevated, and markers of a T cell response occurred but then declined days later. Splenic transforming growth factor beta (TGF-β) expression was elevated early in infection, declined, and then was elevated again late in infection. Together, these data suggest that a subtle immune response that fails to clear the virus occurs in deer mice. PMID:22787210

  17. Loathing the sinner, medicalizing the sin: why sexually violent predator statutes are unjust.

    PubMed

    Douard, John

    2007-01-01

    In seventeen states, persons convicted of one or more sexually violent offenses may be involuntarily civilly committed at the end of their criminal terms if they suffer from a mental disorder that renders them likely to reoffend sexually. These statutes place the burden on states to show that the sex offender meets the United States Constitutional standard of dangerousness. The key to proving dangerousness is proof of a mental disorder. However, the United States Supreme Court recently found that the offender need not be mentally ill. He need only "suffer" from "mental abnormality" or "personality disorder" that affects his cognitive, emotional or volitional capacities such that he is highly likely to sexually reoffend. These statutes are expressions of disgust: a fear of contamination by persons who engage in sexual conduct that forces us to confront our dark impulses. We do not merely hate the sin; we hate the sinner, and we want the sinner to be removed from our presence. Moreover, the emotions these statutes express are the source of widespread moral panic not warranted by data about recidivism risk. Laws that express disgust are likely to result in the unjust treatment of sex offenders.

  18. An Improved Alignment Method for the Strapdown Inertial Navigation System (SINS).

    PubMed

    Liu, Meng; Gao, Yanbin; Li, Guangchun; Guang, Xingxing; Li, Shutong

    2016-01-01

    In this paper, an innovative inertial navigation system (INS) mechanization and the associated Kalman filter (KF) are developed to implement a fine alignment for the strapdown INS (SINS) on stationary base. The improved mechanization is established in the pseudo-geographic frame, which is rebuilt based on the initial position. The new mechanization eliminates the effects of linear movement errors on the heading by decoupling. Compared with the traditional local-level mechanization, it has more advantages. The proposed algorithm requires lower coarse alignment accuracy in both the open-loop and closed-loop KFs and hence can improve the system reliability and decrease the total alignment time. Moreover, for the closed-loop KF, it can decrease oscillation caused by the system errors and improve the closed-loop system stability. In addition, the proposed algorithm can also be applied to polar alignment. The performance of the proposed algorithm is verified by both simulations and experiments and the results exhibit the superior performance of the proposed approach. PMID:27136565

  19. Sin Nombre hantavirus nucleocapsid protein exhibits a metal-dependent DNA-specific endonucleolytic activity.

    PubMed

    Möncke-Buchner, Elisabeth; Szczepek, Michal; Bokelmann, Marcel; Heinemann, Patrick; Raftery, Martin J; Krüger, Detlev H; Reuter, Monika

    2016-09-01

    We demonstrate that the nucleocapsid protein of Sin Nombre hantavirus (SNV-N) has a DNA-specific endonuclease activity. Upon incubation of SNV-N with DNA in the presence of magnesium or manganese, we observed DNA digestion in sequence-unspecific manner. In contrast, RNA was not affected under the same conditions. Moreover, pre-treatment of SNV-N with RNase before DNA cleavage increased the endonucleolytic activity. Structure-based protein fold prediction using known structures from the PDB database revealed that Asp residues in positions 88 and 103 of SNV-N show sequence similarity with the active site of the restriction endonuclease HindIII. Crystal structure of HindIII predicts that residues Asp93 and Asp108 are essential for coordination of the metal ions required for HindIII DNA cleavage. Therefore, we hypothesized that homologous residues in SNV-N, Asp88 and Asp103, may have a similar function. Replacing Asp88 and Asp103 by alanine led to an SNV-N protein almost completely abrogated for endonuclease activity. PMID:27261891

  20. Antibodies with 'Original Antigenic Sin' Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses.

    PubMed

    Linderman, Susanne L; Hensley, Scott E

    2016-08-01

    Human antibodies (Abs) elicited by influenza viruses often bind with a high affinity to past influenza virus strains, but paradoxically, do not bind to the viral strain actually eliciting the response. This phenomena is called 'original antigenic sin' (OAS) since this can occur at the expense of generating new de novo Abs. Here, we characterized the specificity and functionality of Abs elicited in mice that were sequentially exposed to two antigenically distinct H1N1 influenza virus strains. Many Abs elicited under these conditions had an OAS phenotype, in that they bound strongly to the viral strain used for the first exposure and very weakly to the viral strain used for the second exposure. We found that OAS and non-OAS Abs target the same general region of the influenza hemagglutinin protein and that B cells expressing these two types of Abs can be clonally-related. Surprisingly, although OAS Abs bound with very low affinities, some were able to effectively protect against an antigenically drifted viral strain following passive transfer in vivo. Taken together, our data indicate that OAS Abs share some level of cross-reactivity between priming and recall viral strains and that B cells producing these Abs can be protective when recalled into secondary immune responses. PMID:27537358

  1. The Seven (Or More) Deadly (Or Not So Deadly) Sins of Radiation Protection

    SciTech Connect

    Strom, Daniel J.; Stansbury, Paul S.

    2000-06-01

    This editorial considers the errors that can occur in the routine practice of radiation protection in the workplace. This work provides a tool and an incentive for radiation protection professionals to mentally examine their radiation protection responsibilities to identify actions they may take to improve their part of the practice of radiation protection for the benefit of humankind. We introduce a rating tool that is patterned after the IAEA International Nuclear Event Scale.?Sins? discussed include ignorance of the radiological situation, failure to integrate safety management, disabling safety interlocks, warning devices, access controls, omission of''reasonable'' from the policy of''as low as reasonably achievable'' (ALARA), extrapolation of risk beyond reason, using radiation exposure as an excuse for terminating an unwanted pregnancy, escalation of safety requirements beyond reason, failure to average a concentration standard, not responding to concerns (of workers, public, patient s, etc.), over-training, and substitution of prescriptive procedures for judgment. Readers are encouraged to look at their radiation protection activities and judge which ones do not make sense from the viewpoint of protecting people against radiation. It is likely that readers will find more than one radiation protection activity that bears scrutiny.

  2. An Improved Alignment Method for the Strapdown Inertial Navigation System (SINS)

    PubMed Central

    Liu, Meng; Gao, Yanbin; Li, Guangchun; Guang, Xingxing; Li, Shutong

    2016-01-01

    In this paper, an innovative inertial navigation system (INS) mechanization and the associated Kalman filter (KF) are developed to implement a fine alignment for the strapdown INS (SINS) on stationary base. The improved mechanization is established in the pseudo-geographic frame, which is rebuilt based on the initial position. The new mechanization eliminates the effects of linear movement errors on the heading by decoupling. Compared with the traditional local-level mechanization, it has more advantages. The proposed algorithm requires lower coarse alignment accuracy in both the open-loop and closed-loop KFs and hence can improve the system reliability and decrease the total alignment time. Moreover, for the closed-loop KF, it can decrease oscillation caused by the system errors and improve the closed-loop system stability. In addition, the proposed algorithm can also be applied to polar alignment. The performance of the proposed algorithm is verified by both simulations and experiments and the results exhibit the superior performance of the proposed approach. PMID:27136565

  3. Stigmatisation and commercialisation of abortion services in Poland: turning sin into gold.

    PubMed

    Chełstowska, Agata

    2011-05-01

    This paper is about the economic consequences of the stigmatisation and illegality of abortion and its almost complete removal from public health services in Poland since the late 1980s. Once abortion left the public sphere, it entered the grey zone of private arrangements, in which a woman's private worries became someone else's private gain, and her sin turned into gold. The most important consequence was social inequality, as the right to health, life, information and safety became commodities on the free market. Women with money, who are more likely to have political influence, find this bearable, while working class women lack the political capital to protest. In the private sector, there are no government controls on price, quality of care or accountability, and almost no prosecutions. With an estimated 150,000 abortions per year, a rough estimate of US$ 95 million is being generated annually for doctors, unregistered and tax-free. Thus, the combined forces of right-wing ideology and neoliberal economic reforms have created reproductive and social injustice. To address this, stigmatisation of abortion must be countered. But a change in the political climate, a less restrictive interpretation of the law, or even a new law would not resolve the problem. Given reductions in public health care spending, abortion would remain excluded from state coverage unless neoliberal health care reforms could be reversed.

  4. Optimization Algorithm for Kalman Filter Exploiting the Numerical Characteristics of SINS/GPS Integrated Navigation Systems.

    PubMed

    Hu, Shaoxing; Xu, Shike; Wang, Duhu; Zhang, Aiwu

    2015-11-11

    Aiming at addressing the problem of high computational cost of the traditional Kalman filter in SINS/GPS, a practical optimization algorithm with offline-derivation and parallel processing methods based on the numerical characteristics of the system is presented in this paper. The algorithm exploits the sparseness and/or symmetry of matrices to simplify the computational procedure. Thus plenty of invalid operations can be avoided by offline derivation using a block matrix technique. For enhanced efficiency, a new parallel computational mechanism is established by subdividing and restructuring calculation processes after analyzing the extracted "useful" data. As a result, the algorithm saves about 90% of the CPU processing time and 66% of the memory usage needed in a classical Kalman filter. Meanwhile, the method as a numerical approach needs no precise-loss transformation/approximation of system modules and the accuracy suffers little in comparison with the filter before computational optimization. Furthermore, since no complicated matrix theories are needed, the algorithm can be easily transplanted into other modified filters as a secondary optimization method to achieve further efficiency.

  5. Smokers' strategic responses to sin taxes: evidence from panel data in Thailand.

    PubMed

    White, Justin S; Ross, Hana

    2015-02-01

    In addition to quitting and cutting consumption, smokers faced with higher cigarette prices may compensate in several ways that mute the health impact of cigarette taxes. This study examines three price avoidance strategies among adult male smokers in Thailand: trading down to a lower-priced brand, buying individual sticks of cigarettes instead of packs, and substituting roll-your-own tobacco for factory-manufactured cigarettes. Using two panels of microlevel data from the International Tobacco Control Southeast Asia Study, collected in 2005 and 2006, we estimate the effects of a substantial excise tax increase implemented throughout Thailand in December 2005. We present estimates of the marginal effects and price elasticities for each of five consumer behaviors. We find that, controlling for baseline smoking characteristics, sociodemographics, and policy variables, quitting is highly sensitive to changes in cigarette prices, but so are brand choice, stick-buying, and use of roll-your-own tobacco. Neglecting such strategic responses leads to overestimates of a sin tax's health impact, and neglecting product substitution distorts estimates of the price elasticity of cigarette demand. We discuss the implications for consumer welfare and several policies that mitigate the adverse impact of consumer responses. PMID:24677731

  6. The Sin3p PAH Domains Provide Separate Functions Repressing Meiotic Gene Transcription in Saccharomyces cerevisiae ▿

    PubMed Central

    Mallory, Michael J.; Law, Michael J.; Buckingham, Lela E.; Strich, Randy

    2010-01-01

    Meiotic genes in budding yeast are repressed during vegetative growth but are transiently induced during specific stages of meiosis. Sin3p represses the early meiotic gene (EMG) by bridging the DNA binding protein Ume6p to the histone deacetylase Rpd3p. Sin3p contains four paired amphipathic helix (PAH) domains, one of which (PAH3) is required for repressing several genes expressed during mitotic cell division. This report examines the roles of the PAH domains in mediating EMG repression during mitotic cell division and following meiotic induction. PAH2 and PAH3 are required for mitotic EMG repression, while electrophoretic mobility shift assays indicate that only PAH2 is required for stable Ume6p-promoter interaction. Unlike mitotic repression, reestablishing EMG repression following transient meiotic induction requires PAH3 and PAH4. In addition, the role of Sin3p in reestablishing repression is expanded to include additional loci that it does not control during vegetative growth. These findings indicate that mitotic and postinduction EMG repressions are mediated by two separate systems that utilize different Sin3p domains. PMID:20971827

  7. Development of SCAR markers linked to sin-2, the stringless pod locus in pea (Pisum sativum L.)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    With increasing consumer demand for vegetables, edible-podded peas have become more popular. Stringlessness is one of most important traits for snap peas. A single recessive gene, sin-2, controls this trait. Because pollen carrying the stringless gene is less competitive than pollen carrying the str...

  8. The Determination of sin{sup 2} {theta}{sub W} in Neutrino Scattering: no more anomaly

    SciTech Connect

    Thomas, A. W.

    2011-12-14

    We review the corrections to the NuTeV determination of sin{sup 2} {theta}{sub W}, concluding that it is no longer appropriate to present it as an ''anomaly''. Indeed, when well understood corrections associated with charge symmetry violation and the iso-vector nuclear force are properly included, the measurement is completely consistent with the Standard Model.

  9. Characterization of mustard 2S albumin allergens by bottom-up, middle-down, and top-down proteomics: a consensus set of isoforms of Sin a 1.

    PubMed

    Hummel, Marlene; Wigger, Tina; Brockmeyer, Jens

    2015-03-01

    The mustard allergen Sin a 1 belongs to the 2S-albumin family of seed-storage proteins. Because of its high abundance in mustard seeds and the potential to elicit severe allergenic reactions, Sin a 1 is considered to be a major allergen in mustard. Eight Sin a 1 isoforms have been identified using DNA cloning and sequencing, and we aim in this study to thoroughly investigate sequence heterogeneity using a novel combination of bottom-up, middle-down, and top-down proteomics. The characterization of purified Sin a 1 extract shows that sequence diversity is far more pronounced than previously assumed. We identified in total 24 sequence polymorphisms including 17 yet unpublished point mutations. Using middle-down and top-down approaches on the subunit and protein level of Sin a 1, we were able to detect eight consensus isoforms of Sin a 1(including four novel isoforms), which we detect in the majority of the four different mustard samples included in this study. In addition, we provide for the first time data on relative abundance of the main Sin a 1 isoforms and identify phytic acid as a potential ligand of Sin a 1. Together, these data can form the basis for a more detailed investigation of the effect of Sin a 1 polymorphic sites on allergenicity of isoforms. PMID:25660635

  10. Reliability of the Spinal Instability Neoplastic Score (SINS) among radiation oncologists: an assessment of instability secondary to spinal metastases

    PubMed Central

    2014-01-01

    Background The Spinal Instability Neoplastic Score (SINS) categorizes tumor related spinal instability. It has the potential to streamline the referral of patients with established or potential spinal instability to a spine surgeon. This study aims to define the inter- and intra-observer reliability and validity of SINS among radiation oncologists. Methods Thirty-three radiation oncologists, across ten international sites, rated 30 neoplastic spinal disease cases. For each case, the total SINS (0-18 points), three clinical categories (stable: 0-6 points, potentially unstable: 7-12 points, and unstable: 13-18 points), and a binary scale (‘stable’: 0-6 points and ‘current or possible instability’; surgical consultation recommended: 7-18 points) were recorded. Evaluation was repeated 6-8 weeks later. Inter-observer agreement and intra-observer reproducibility were calculated by means of the kappa statistic and translated into levels of agreement (slight, fair, moderate, substantial, and excellent). Validity was determined by comparing the ratings against a spinal surgeon’s consensus standard. Results Radiation oncologists demonstrated substantial (κ = 0.76) inter-observer and excellent (κ = 0.80) intra-observer reliability when using the SINS binary scale (‘stable’ versus ‘current or possible instability’). Validity of the binary scale was also excellent (κ = 0.85) compared with the gold standard. None of the unstable cases was rated as stable by the radiation oncologists ensuring all were appropriately recommended for surgical consultation. Conclusions Among radiation oncologists SINS is a highly reliable, reproducible, and valid assessment tool to address a key question in tumor related spinal disease: Is the spine ‘stable’ or is there ‘current or possible instability’ that warrants surgical assessment? PMID:24594004

  11. THE SINS/zC-SINF SURVEY of z {approx} 2 GALAXY KINEMATICS: OUTFLOW PROPERTIES

    SciTech Connect

    Newman, Sarah F.; Genzel, Reinhard; Foerster-Schreiber, Natascha M.; Buschkamp, Peter; Davies, Ric; Eisenhauer, Frank; Kurk, Jaron; Lutz, Dieter; Griffin, Kristen Shapiro; Mancini, Chiara; Renzini, Alvio; Lilly, Simon J.; Carollo, C. Marcella; Peng, Yingjie; Bouche, Nicolas; Burkert, Andreas; Cresci, Giovanni; Genel, Shy; Hicks, Erin K. S.; Naab, Thorsten; and others

    2012-12-10

    Using SINFONI H{alpha}, [N II], and [S II] AO data of 27 z {approx} 2 star-forming galaxies (SFGs) from the SINS and zC-SINF surveys, we explore the dependence of outflow strength (via the broad flux fraction) on various galaxy parameters. For galaxies that have evidence for strong outflows, we find that the broad emission is spatially extended to at least the half-light radius ({approx}a few kpc). Decomposition of the [S II] doublet into broad and narrow components suggests that this outflowing gas probably has a density of {approx}10-100 cm{sup -3}, less than that of the star-forming gas (600 cm{sup -3}). There is a strong correlation of the H{alpha} broad flux fraction with the star formation surface density of the galaxy, with an apparent threshold for strong outflows occurring at 1 M{sub Sun} yr{sup -1} kpc{sup -2}. Above this threshold, we find that SFGs with log m{sub *} > 10 have similar or perhaps greater wind mass-loading factors ({eta} = M-dot{sub out}/SFR) and faster outflow velocities than lower mass SFGs, suggesting that the majority of outflowing gas at z {approx} 2 may derive from high-mass SFGs. The mass-loading factor is also correlated with the star formation rate (SFR), galaxy size, and inclination, such that smaller, more star-forming, and face-on galaxies launch more powerful outflows. We propose that the observed threshold for strong outflows and the observed mass loading of these winds can be explained by a simple model wherein break-out of winds is governed by pressure balance in the disk.

  12. Precise Measurement of the CP Violation Parameter sin2Φ1 in B⁰→(cc̄)K⁰ Decays

    DOE PAGESBeta

    Adachi, I.; Aihara, H.; Asner, D. M.; Aulchenko, V.; Aushev, T.; Aziz, T.; Bakich, A. M.; Bay, A.; Bhardwaj, V.; Bhuyan, B.; et al

    2012-04-23

    We present a precise measurement of the CP violation parameter sin2Φ1 and the direct CP violation parameter Af using the final data sample of 772×10⁶ BB¯¯¯ pairs collected at the Υ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider. One neutral B meson is reconstructed in a J/ψK0S, ψ(2S)K0S, χc1K0S, or J/ψK0L CP eigenstate and its flavor is identified from the decay products of the accompanying B meson. From the distribution of proper-time intervals between the two B decays, we obtain the following CP violation parameters: sin2Φ1=0.667±0.023(stat)±0.012(syst) and Af=0.006±0.016(stat)±0.012(syst).

  13. Long-term patterns of immune investment by wild deer mice infected with Sin Nombre virus.

    PubMed

    Lehmer, Erin M; Jones, Jeremy D; Bego, Mariana G; Varner, Johanna M; Jeor, Stephen St; Clay, Christine A; Dearing, M Denise

    2010-01-01

    Immunocompetence of animals fluctuates seasonally, However, there is little consensus on the cause of these fluctuations. Some studies have suggested that these patterns are influenced by changes in reproductive condition, whereas others have suggested that differences result from seasonal variations in energy expenditures. The objective of our study was to examine these contrasting views of immunity by evaluating seasonal patterns of immune response and reproduction in wild populations of deer mice Peromyscus maniculatus exposed to Sin Nombre virus (SNV). Over three consecutive fall (September, October, November) and three consecutive spring (March, April, May) sampling periods, we used titration enzyme-linked immunosorbent assay (ELISA) to quantify virus-specific antibody production in 48 deer mice infected with SNV. Levels of reproductive hormones were quantified using ELISA. SNV antibody titers reached their lowest level during November (geometric mean titer [GMT] = 420) and their highest levels during September (GMT = 5,545) and May (GMT = 3,582), suggesting that the immune response of deer mice to SNV has seasonal patterns. The seeming decrease in antibody titer over winter coupled with the consistency in body masses suggests that during winter, immunocompetence may be compromised to offset the energetic costs of maintenance functions, including those associated with maintaining body mass. Deer mice showed distinct sex-based differences in SNV antibody production, with males producing higher antibody titers (GMT = 3,333) than females (GMT = 1,477). Levels of reproductive hormones do not appear to influence antibody production in either males or females, as there was no correlation between estradiol concentrations and SNV antibody titer in female deer mice (r² = 0.26), nor was there a significant relationship between levels of testosterone and SNV antibody titers in males (r² = 0.28). Collectively, this study demonstrates that immunocompetence of wild deer

  14. The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation

    PubMed Central

    Zilfou, Jack T.; Hoffman, William H.; Sank, Michael; George, Donna L.; Murphy, Maureen

    2001-01-01

    While the transactivation function of the tumor suppressor p53 is well understood, less is known about the transrepression functions of this protein. We have previously shown that p53 interacts with the corepressor protein mSin3a (hereafter designated Sin3) in vivo and that this interaction is critical for the ability of p53 to repress gene expression. In the present study, we demonstrate that expression of Sin3 results in posttranslational stabilization of both exogenous and endogenous p53, due to an inhibition of proteasome-mediated degradation of this protein. Stabilization of p53 by Sin3 requires the Sin3-binding domain, determined here to map to the proline-rich region of p53, from amino acids 61 to 75. The correlation between Sin3 binding and stabilization supports the hypothesis that this domain of p53 may normally be subject to a destabilizing influence. The finding that a synthetic mutant of p53 lacking the Sin3-binding domain has an increased half-life in cells, compared to wild-type p53, supports this premise. Interestingly, unlike retinoblastoma tumor suppressor protein, MDMX, and p14ARF, Sin3 stabilizes p53 in an MDM2-independent manner. The ability of Sin3 to stabilize p53 is consistent with the model whereby these two proteins must exist on a promoter for extended periods, in order for repression to be an effective mechanism of gene regulation. This model is consistent with our data indicating that, unlike the p300-p53 complex, the p53-Sin3 complex is immunologically detectable for prolonged periods following exposure of cells to agents of DNA damage. PMID:11359905

  15. The Legacy of Hideki Yukawa, Sin-itiro Tomonaga, and Shoichi Sakata: Some Aspects from their Archives

    NASA Astrophysics Data System (ADS)

    Konuma, Michiji; Bando, Masako; Gotoh, Haruyoshi; Hayakawa, Hisao; Hirata, Kohji; Ito, Kazuyuki; Ito, Kenji; Kanaya, Kazuyuki; Konagaya, Daisuke; Kugo, Taichiro; Namba, Chusei; Nishitani, Tadashi; Takaiwa, Yoshinobu; Tanabashi, Masaharu; Tanaka, Kio; Tanaka, Sho; Ukegawa, Fumihiko; Yoshikawa, Tadashi

    Hideki Yukawa, Sin-itiro Tomonaga and Shoichi Sakata pioneered nuclear and particle physics and left enduring legacies. Their friendly collaboration and severe competition laid the foundation to bring up the active postwar generation of nuclear and particle physicists in Japan. In this presentation we illustrate milestones of nuclear and particle physics in Japan from 1930's to mid-1940's which have been clarified in Yukawa Hall Archival Library, Tomonaga Memorial Room and Sakata Memorial Archival Library.

  16. The seven deadly sins of physician practice management. How to stop committing them to gain a competitive edge.

    PubMed

    Sterling, J

    1998-01-01

    Many words have been written about how the marketplace is changing--and hurting--medical group practice. However, not all problems are external. Physicians and managers are doing some of the harm to themselves. "Deadly sins," including a lack of urgency, copycat strategies, trend chasing and the creation of meaningless networks, inhibit growth. Avoiding these mistakes can make it easier to handle those changes group practices can't control.

  17. The devil is in the details: the seven deadly sins of organizing and continuing interprofessional education in the US.

    PubMed

    Clark, Phillip G

    2011-09-01

    In spite of increased calls for expanding interprofessional practice (IPP) in the US health care system to address concerns about patient safety and quality of care, there has not been a corresponding dramatic growth in interprofessional education (IPE) programs. Indeed, the history of IPE in the US has been a roller-coaster ride of gains and losses, successes and failures. Understanding why this has been so requires the development of a personal and political economy framework, based on an understanding of the structural, ideological, and economic factors and forces that characterize IPE in American higher education. Using a metaphor of the seven deadly sins (lust, pride, greed, gluttony, envy, sloth, and wrath), this discussion focuses on both things that should not be done (sins of commission) and those that should be done but are not (sins of omission) to create successful and sustainable IPE programs. Taken together, these factors help to frame a perspective on IPE that highlights the essential knowledge, attitudes, and skills needed by faculty and administrators to create, implement, and - most importantly - sustain successful programs. Implications of this framework for promoting increased IPE are discussed, particularly with respect to insuring its successful continuation into the future.

  18. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

    PubMed

    Jacinto, Estela; Facchinetti, Valeria; Liu, Dou; Soto, Nelyn; Wei, Shiniu; Jung, Sung Yun; Huang, Qiaojia; Qin, Jun; Su, Bing

    2006-10-01

    Mammalian target of rapamycin (mTOR) controls cell growth and proliferation via the raptor-mTOR (TORC1) and rictor-mTOR (TORC2) protein complexes. Recent biochemical studies suggested that TORC2 is the elusive PDK2 for Akt/PKB Ser473 phosphorylation in the hydrophobic motif. Phosphorylation at Ser473, along with Thr308 of its activation loop, is deemed necessary for Akt function, although the regulatory mechanisms and physiological importance of each phosphorylation site remain to be fully understood. Here, we report that SIN1/MIP1 is an essential TORC2/PDK2 subunit. Genetic ablation of sin1 abolished Akt-Ser473 phosphorylation and disrupted rictor-mTOR interaction but maintained Thr308 phosphorylation. Surprisingly, defective Ser473 phosphorylation affected only a subset of Akt targets in vivo, including FoxO1/3a, while other Akt targets, TSC2 and GSK3, and the TORC1 effectors, S6K and 4E-BP1, were unaffected. Our findings reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function. PMID:16962653

  19. The devil is in the details: the seven deadly sins of organizing and continuing interprofessional education in the US.

    PubMed

    Clark, Phillip G

    2011-09-01

    In spite of increased calls for expanding interprofessional practice (IPP) in the US health care system to address concerns about patient safety and quality of care, there has not been a corresponding dramatic growth in interprofessional education (IPE) programs. Indeed, the history of IPE in the US has been a roller-coaster ride of gains and losses, successes and failures. Understanding why this has been so requires the development of a personal and political economy framework, based on an understanding of the structural, ideological, and economic factors and forces that characterize IPE in American higher education. Using a metaphor of the seven deadly sins (lust, pride, greed, gluttony, envy, sloth, and wrath), this discussion focuses on both things that should not be done (sins of commission) and those that should be done but are not (sins of omission) to create successful and sustainable IPE programs. Taken together, these factors help to frame a perspective on IPE that highlights the essential knowledge, attitudes, and skills needed by faculty and administrators to create, implement, and - most importantly - sustain successful programs. Implications of this framework for promoting increased IPE are discussed, particularly with respect to insuring its successful continuation into the future. PMID:21823881

  20. (1)H, (15)N and (13)C resonance assignments of the conserved region in the middle domain of S. pombe Sin1 protein.

    PubMed

    Kataoka, Saori; Furuita, Kyoko; Hattori, Yoshikazu; Kobayashi, Naohiro; Ikegami, Takahisa; Shiozaki, Kazuhiro; Fujiwara, Toshimichi; Kojima, Chojiro

    2015-04-01

    SAPK-interacting protein 1 (Sin1) is an important component of the target of rapamycin (TOR) complex 2 (TORC2). TOR is a serine/threonine-specific protein kinase and forms functionally distinct protein complexes referred to as TORC1 and TORC2. TORC2, conserved from yeast to humans, phosphorylates AGC-family protein kinases and has many cellular functions including the regulation of actin cytoskeleton. The Sin1 subunit of TORC2 is required for the binding of TORC2 to substrates, and the conserved region in the middle (CRIM) domain of Sin1 is important in the substrate recognition of TORC2. Here, we report on the (1)H, (13)C and (15)N resonance assignments of fission yeast Schizosaccharomyces pombe Sin1 (amino acids 247-400) (Sin1CRIM), which possesses the CRIM domain. These data contribute toward the structure determination of Sin1CRIM and an understanding of the interactions of Sin1CRIM with substrates of TORC2.

  1. Biofilm formation by Bacillus subtilis requires an endoribonuclease-containing multisubunit complex that controls mRNA levels for the matrix gene repressor SinR.

    PubMed

    DeLoughery, Aaron; Dengler, Vanina; Chai, Yunrong; Losick, Richard

    2016-01-01

    Biofilm formation by Bacillus subtilis is largely governed by a circuit in which the response regulator Spo0A turns on the gene for the anti-repressor SinI. SinI, in turn, binds to and inactivates SinR, a dedicated repressor of genes for matrix production. Mutants of the genes ylbF, ymcA and yaaT are blocked in biofilm formation, but the mechanism by which they act has been mysterious. A recent report attributed their role in biofilm formation to stimulating Spo0A activity. However, we detect no measurable effect on the transcription of sinI. Instead, we find that the block in biofilm formation is caused by an increase in the levels of SinR and of its mRNA. Evidence is presented that YlbF, YmcA and YaaT interact with, and control the activity of, RNase Y, which is known to destabilize sinR mRNA. We also show that the processing of another target of RNase Y, cggR-gapA mRNA, similarly depends on YlbF and YmcA. Our work suggests that sinR mRNA stability is an additional posttranscriptional control mechanism governing the switch to multicellularity and raises the possibility that YlbF, YmcA and YaaT broadly regulate mRNA stability as part of an RNase Y-containing, multi-subunit complex.

  2. Selective inhibition of SIN3 corepressor with avermectins as a novel therapeutic strategy in triple negative breast cancer

    PubMed Central

    Kwon, Yeon-Jin; Petrie, Kevin; Leibovitch, Boris A.; Zeng, Lei; Mezei, Mihaly; Howell, Louise; Gil, Veronica; Christova, Rossitza; Bansal, Nidhi; Yang, Shuai; Sharma, Rajal; Ariztia, Edgardo V.; Frankum, Jessica; Brough, Rachel; Sbirkov, Yordan; Ashworth, Alan; Lord, Christopher J.; Zelent, Arthur; Farias, Eduardo; Zhou, Ming-Ming; Waxman, Samuel

    2015-01-01

    Triple negative breast cancers (TNBC) lacking estrogen, progesterone and HER2 receptors account for 10–20% of breast cancer and are indicative of poor prognosis. The development of effective treatment strategies therefore represents a pressing unmet clinical need. We previously identified a molecularly-targeted approach to target aberrant epigenetics of TNBC using a peptide corresponding to the SIN3 interaction domain (SID) of MAD. SID peptide selectively blocked binding of SID-containing proteins to the paired α-helix (PAH2) domain of SIN3, resulting in epigenetic and transcriptional modulation of genes associated with epithelial-mesenchymal transition (EMT). To find small molecule inhibitor (SMI) mimetics of SID peptide we performed an in silico screen for PAH2 domain-binding compounds. This led to the identification of the avermectin macrocyclic lactone derivatives selamectin and ivermectin (Mectizan) as candidate compounds. Both selamectin and ivermectin phenocopied the effects of SID peptide to block SIN3-PAH2 interaction with MAD, induce expression of CDH1 and ESR1 and restore tamoxifen sensitivity in MDA-MB-231 human and MMTV-Myc mouse TNBC cells in vitro. Treatment with selamectin or ivermectin led to transcriptional modulation of genes associated with EMT and maintenance of a cancer stem cell phenotype in TNBC cells. This resulted in impairment of clonogenic self-renewal in vitro and inhibition of tumor growth and metastasis in vivo. Underlining the potential of avermectins in TNBC, pathway analysis revealed that selamectin also modulated the expression of therapeutically-targetable genes. Consistent with this, an unbiased drug screen in TNBC cells identified selamectin-induced sensitization to a number of drugs, including those targeting modulated genes. PMID:26078298

  3. Surface donor states distribution post SiN passivation of AlGaN/GaN heterostructures

    SciTech Connect

    Goyal, Nitin; Fjeldly, Tor A.

    2014-07-21

    In this paper, we present a physics based analytical model to describe the effect of SiN passivation on two-dimensional electron gas density and surface barrier height in AlGaN/GaN heterostructures. The model is based on an extraction technique to calculate surface donor density and surface donor level at the SiN/AlGaN interface. The model is in good agreement with the experimental results and promises to become a useful tool in advanced design and characterization of GaN based heterostructures.

  4. Preparation and properties of Nb/Al SIS and SIN junctions for millimeter and submillimeter radioastronomical receivers

    NASA Astrophysics Data System (ADS)

    Gundlach, K. H.; Lehnert, T.; Billon-Pierron, D.; Voss, M.; Pasturel, P.

    1992-12-01

    The sharp onset of the quasiparticle current in Superconductor Insulator Superconductor (SIS) tunnel junctions is used for frequency mixing in radioastronomical receivers. Efforts to develop and routinely produce various Nb based devices for frequencies up to 690 GHz are outlined. The fabrication and properties of single (SIS) and double barrier (SISIS) devices, anodization spectroscopy, thermal annealing, a method to prepare submicron junctions using optical lithography and on Nb based SIN junctions, are reported. The latter type has no Josephson effects which can interfere with low noise quasiparticle mixing.

  5. The stress-related, rhizobial small RNA RcsR1 destabilizes the autoinducer synthase encoding mRNA sinI in Sinorhizobium meliloti

    PubMed Central

    Baumgardt, Kathrin; Šmídová, Klára; Rahn, Helen; Lochnit, Günter; Robledo, Marta; Evguenieva-Hackenberg, Elena

    2016-01-01

    ABSTRACT Quorum sensing is a cell density-dependent communication system of bacteria relying on autoinducer molecules. During the analysis of the post-transcriptional regulation of quorum sensing in the nitrogen fixing plant symbiont Sinorhizobium meliloti, we predicted and verified a direct interaction between the 5'-UTR of sinI mRNA encoding the autoinducer synthase and a small RNA (sRNA), which we named RcsR1. In vitro, RcsR1 prevented cleavage in the 5'-UTR of sinI by RNase E and impaired sinI translation. In line with low ribosomal occupancy and transcript destabilization upon binding of RcsR1 to sinI, overproduction of RcsR1 in S. meliloti resulted in lower level and shorter half-life of sinI mRNA, and in decreased autoinducer amount. Although RcsR1 can influence quorum sensing via sinI, its level did not vary at different cell densities, but decreased under salt stress and increased at low temperature. We found that RcsR1 and its stress-related expression pattern, but not the interaction with sinI homologs, are conserved in Sinorhizobium, Rhizobium and Agrobacterium. Consistently, overproduction of RcsR1 in S. meliloti and Agrobacterium tumefaciens inhibited growth at high salinity. We identified conserved targets of RcsR1 and showed that most conserved interactions and the effect on growth under salt stress are mediated by the first stem-loop of RcsR1, while its central part is responsible for the species-specific interaction with sinI. We conclude that RcsR1 is an ancient, stress-related riboregulator in rhizobia and propose that it links stress responses to quorum sensing in S. meliloti. PMID:26588798

  6. The stress-related, rhizobial small RNA RcsR1 destabilizes the autoinducer synthase encoding mRNA sinI in Sinorhizobium meliloti.

    PubMed

    Baumgardt, Kathrin; Šmídová, Klára; Rahn, Helen; Lochnit, Günter; Robledo, Marta; Evguenieva-Hackenberg, Elena

    2016-05-01

    Quorum sensing is a cell density-dependent communication system of bacteria relying on autoinducer molecules. During the analysis of the post-transcriptional regulation of quorum sensing in the nitrogen fixing plant symbiont Sinorhizobium meliloti, we predicted and verified a direct interaction between the 5'-UTR of sinI mRNA encoding the autoinducer synthase and a small RNA (sRNA), which we named RcsR1. In vitro, RcsR1 prevented cleavage in the 5'-UTR of sinI by RNase E and impaired sinI translation. In line with low ribosomal occupancy and transcript destabilization upon binding of RcsR1 to sinI, overproduction of RcsR1 in S. meliloti resulted in lower level and shorter half-life of sinI mRNA, and in decreased autoinducer amount. Although RcsR1 can influence quorum sensing via sinI, its level did not vary at different cell densities, but decreased under salt stress and increased at low temperature. We found that RcsR1 and its stress-related expression pattern, but not the interaction with sinI homologs, are conserved in Sinorhizobium, Rhizobium and Agrobacterium. Consistently, overproduction of RcsR1 in S. meliloti and Agrobacterium tumefaciens inhibited growth at high salinity. We identified conserved targets of RcsR1 and showed that most conserved interactions and the effect on growth under salt stress are mediated by the first stem-loop of RcsR1, while its central part is responsible for the species-specific interaction with sinI. We conclude that RcsR1 is an ancient, stress-related riboregulator in rhizobia and propose that it links stress responses to quorum sensing in S. meliloti. PMID:26588798

  7. Proper Actin Ring Formation and Septum Constriction Requires Coordinated Regulation of SIN and MOR Pathways through the Germinal Centre Kinase MST-1

    PubMed Central

    Heilig, Yvonne; Dettmann, Anne; Mouriño-Pérez, Rosa R.; Schmitt, Kerstin; Valerius, Oliver; Seiler, Stephan

    2014-01-01

    Nuclear DBF2p-related (NDR) kinases constitute a functionally conserved protein family of eukaryotic regulators that control cell division and polarity. In fungi, they function as effector kinases of the morphogenesis (MOR) and septation initiation (SIN) networks and are activated by pathway-specific germinal centre (GC) kinases. We characterized a third GC kinase, MST-1, that connects both kinase cascades. Genetic and biochemical interactions with SIN components and life cell imaging identify MST-1 as SIN-associated kinase that functions in parallel with the GC kinase SID-1 to activate the SIN-effector kinase DBF-2. SID-1 and MST-1 are both regulated by the upstream SIN kinase CDC-7, yet in an opposite manner. Aberrant cortical actomyosin rings are formed in Δmst-1, which resulted in mis-positioned septa and irregular spirals, indicating that MST-1-dependent regulation of the SIN is required for proper formation and constriction of the septal actomyosin ring. However, MST-1 also interacts with several components of the MOR network and modulates MOR activity at multiple levels. MST-1 functions as promiscuous enzyme and also activates the MOR effector kinase COT-1 through hydrophobic motif phosphorylation. In addition, MST-1 physically interacts with the MOR kinase POD-6, and dimerization of both proteins inactivates the GC kinase hetero-complex. These data specify an antagonistic relationship between the SIN and MOR during septum formation in the filamentous ascomycete model Neurospora crassa that is, at least in part, coordinated through the GC kinase MST-1. The similarity of the SIN and MOR pathways to the animal Hippo and Ndr pathways, respectively, suggests that intensive cross-communication between distinct NDR kinase modules may also be relevant for the homologous NDR kinases of higher eukaryotes. PMID:24762679

  8. An array of 100 Al Al2O3 Cu SIN tunnel junctions in direct-write trilayer technology

    NASA Astrophysics Data System (ADS)

    Otto, Ernst; Tarasov, Mikhail; Pettersson, Gustav; Gustavsson, David; Kuzmin, Leonid

    2007-12-01

    We present superconductor-insulator-normal metal (SIN) tunnel junction thermometers made of arrays of 4-100 Al-Al2O3-Cu SIN tunnel junctions fabricated in direct-write technology. The technology is based on in situ evaporation of the superconductive electrode followed by the oxidation and the normal counter-electrode as a first step and deposition of normal metal absorber as a second one. This approach allows one to realize any geometry of the tunnel junctions and of the absorber with no limitation related to the size of the junctions or the absorber, which is not possible using the shadow evaporation technique. Measurements performed at 300 mK showed the high quality of the fabricated tunnel junctions, low leakage currents, and that an Rd/Rn ratio of 500 has been achieved at that temperature. The junctions were characterized as temperature sensors, and voltage versus temperature dependence measurements showed a dV/dT of 0.5 mV K-1 for each single junction, which is typical for this kind of tunnel junction. A temperature resolution of ± 5 µK has been achieved which is much better than the previously reported value of ± 30 µK for this type of thermometer.

  9. Keeping things quiet: Roles of NuRD and Sin3 co-repressor complexes during mammalian development

    PubMed Central

    McDonel, Patrick; Costello, Ita; Hendrich, Brian

    2010-01-01

    Gene inactivation studies of mammalian histone and DNA-modifying proteins have demonstrated a role for many such proteins in embryonic development. Post-implantation embryonic lethality implies a role for epigenetic factors in differentiation and in development of specific lineages or tissues. However a handful of chromatin-modifying enzymes have been found to be required in pre- or peri-implantation embryos. This is significant as implantation is the time when inner cell mass cells of the blastocyst exit pluripotency and begin to commit to form the various lineages that will eventually form the adult animal. These observations indicate a critical role for chromatin-modifying proteins in the earliest lineage decisions of mammalian development, and/or in the formation of the first embryonic cell types. Recent work has shown that the two major class I histone deacetylase-containing co-repressor complexes, the NuRD and Sin3 complexes, are both required at peri-implantation stages of mouse development, demonstrating the importance of histone deacetylation in cell fate decisions. Over the past 10 years both genetic and biochemical studies have revealed surprisingly divergent roles for these two co-repressors in mammalian cells. In this review we will summarise the evidence that the two major class I histone deacetylase complexes in mammalian cells, the NuRD and Sin3 complexes, play important roles in distinct aspects of embryonic development. PMID:18775506

  10. Tube-shaped Pirani gauge for in situ hermeticity monitoring of SiN thin-film encapsulation

    NASA Astrophysics Data System (ADS)

    Santagata, F.; Creemer, J. F.; Iervolino, E.; Sarro, P. M.

    2012-10-01

    Here the integration of a tube-shaped Pirani gauge with a SiN thin-film encapsulation process is presented. The tube geometry gives the sensor a very low detection limit with a small footprint, since the tube is buried under the silicon surface. The Pirani tube is very suitable for in situ evaluation of MEMS vacuum packaging. Moreover, since the Pirani gap is all around the tube and deep below the silicon surface, the deflection of the encapsulation shell is not a concern and wafer-level measurement of the device is possible. Pirani tubes with different lengths are encapsulated inside SiN micropackages in order to measure the resulting vacuum level achieved after the encapsulation step. The longest tube shows a detection limit of 0.1 Pa for a noise level of 50 μV and it has a footprint of only 0.006 mm2. The pressure inside the sealed micropackage was extracted to be 0.7 kPa. Furthermore, the pressure is monitored over time to evaluate the hermeticity of the packages. A leak rate of 8× 10-18 Pa m3 s-1 was measured over four months time.

  11. Review of the chronostratigraphic charts in the Sinú-San Jacinto basin based on new seismic stratigraphic interpretations

    NASA Astrophysics Data System (ADS)

    Alfaro, Esteban; Holz, Michael

    2014-12-01

    Disperse and punctual studies; absence of integration of data ranging from local to regional focus; interpretations based only on lithostratigraphic features; and interpretation of data premised on an allochthonous origin of the Caribbean plate, are some of factors that increase the confusion and uncertainty in understanding the Sinú-San Jacinto Basin. The sedimentary record of Upper Cretaceous to Eocene has been traditionally interpreted as the record of deep-water settings. However, recently these sediments have been related to shallow marine and deltaic settings. Second problematic point is about the deposition environment of the Oligocene to Late Miocene succession. Some studies suggest canyons, turbidites and sediments deposited in deep-water settings. However, recent studies propose deltaic and shallow marine settings. The last stratigraphic problem is related to the controversial fluvial vs. shallow marine interpretations of the Pliocene sediments. Based upon seismic stratigraphic analysis in recent and reprocessed 2D seismic data, integrated with well data, we propose chronostratigraphic charts for the northern, central and southern zones of the Sinú-San Jacinto Basin. Twenty seismic facies based on amplitude, continuity, frequency and geometry of seismic reflectors and twelve seismic sequences were recognized. The seismic stratigraphic analysis in this study suggests that the sediments of Upper Cretaceous to Paleocene/Eocene were associated to continental to shallow marine settings. Lagoons, coastal plain and carbonate platform dominated during this period. The Oligocene to Middle Miocene record was characterized by deep-water deposition, whereas the Late Miocene to recent sedimentation was characterized by falling base level, characterized by deltaic and fluvial deposits. Five syn-rift sequences with wedge-shaped geometry were identified in this study. Three Triassic to Jurassic syn-rift sequences were characterized by seismic facies typical of fluvial

  12. Determination of sin{sup 2}θ{sub W} using ν (ν{sup ¯})-nucleus scattering

    SciTech Connect

    Haider, H.; Athar, M. Sajjad; Simo, I. Ruiz

    2015-05-15

    We have studied nonisoscalarity and medium effects in the extraction of weak mixing angle using Paschos and Wolfenstein relation in the iron nucleus. Paschos and Wolfenstein(PW) relation is valid for an isoscalar target. We have modified the PW relation for nonisoscalar target as well as incorporated the medium effects like Pauli blocking, Fermi motion, nuclear binding energy and pion rho cloud contributions. In our calculations we have used the relativistic nuclear spectral function which includes nucleon correlations. Finally local density approximation is applied to translate the numerical results to the finite nuclei. We have studied the dependence of sin{sup 2}θ{sub W} on Bjorken variables x and y, four momentum transfer square (Q{sup 2}), energy of the neutrino and antineutrino, and effect of excess neutrons over protons in the nuclear target.

  13. Influence of SST from Pacific and Atlantic Ocean and atmospheric circulation in the precipitation regime of basin from Brazilian SIN

    NASA Astrophysics Data System (ADS)

    Custodio, M. D.; Ramos, C. G.; Madeira, P.; de Macedo, A. L.

    2013-12-01

    The South American climate presents tropical, subtropical and extratropical features because of its territorial extension, being influenced by a variety of dynamical systems with different spatial and temporal scales which result in different climatic regimes in their subregions. Furthermore, the precipitation regime in South America is influenced by low-frequency phenomena as El Niño-Southern Oscillation (ENSO), the Atlantic dipole and the Madden Julian Oscilation (MJO), in other words, is directly influenced by variations of the Sea Surface Temperature (SST). Due to the importance of the precipitation for many sectors including the planning of productive activities, such as agriculture, livestock and hydropower energy, many studies about climate variations in Brazil have tried to determine and explain the mechanisms that affect the precipitation regime. However, because of complexity of the climate system, and consequently of their impacts on the global precipitation regime, its interactions are not totally understood and therefore misrepresented in numerical models used to forecast climate. The precipitation pattern over hydrographic basin which form the Brasilian National Interconnected System (Sistema Interligado Nacional-SIN) are not yet known and therefore the climate forecast of these regions still presents considerable failure that need to be corrected due to its economic importance. In this context, the purpose here is to determine the precipitation patterns on the Brazilian SIN, based on SST and circulation observed data. In a second phase a forecast climate model for these regions will be produced. In this first moment 30 years (1983 to 2012) of SST over Pacific and Atlantic Ocean were analyzed, along with wind in 850 and 200 hPa and precipitation observed data. The precipitation patterns were analyzed through statistical analyses for interannual (ENSO) and intraseasonal (MJO) anomalies for these variables over the SIN basin. Subsequently, these

  14. Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.

    PubMed

    Witteveen, Josefine S; Willemsen, Marjolein H; Dombroski, Thaís C D; van Bakel, Nick H M; Nillesen, Willy M; van Hulten, Josephus A; Jansen, Eric J R; Verkaik, Dave; Veenstra-Knol, Hermine E; van Ravenswaaij-Arts, Conny M A; Wassink-Ruiter, Jolien S Klein; Vincent, Marie; David, Albert; Le Caignec, Cedric; Schieving, Jolanda; Gilissen, Christian; Foulds, Nicola; Rump, Patrick; Strom, Tim; Cremer, Kirsten; Zink, Alexander M; Engels, Hartmut; de Munnik, Sonja A; Visser, Jasper E; Brunner, Han G; Martens, Gerard J M; Pfundt, Rolph; Kleefstra, Tjitske; Kolk, Sharon M

    2016-08-01

    Numerous genes are associated with neurodevelopmental disorders such as intellectual disability and autism spectrum disorder (ASD), but their dysfunction is often poorly characterized. Here we identified dominant mutations in the gene encoding the transcriptional repressor and MeCP2 interactor switch-insensitive 3 family member A (SIN3A; chromosome 15q24.2) in individuals who, in addition to mild intellectual disability and ASD, share striking features, including facial dysmorphisms, microcephaly and short stature. This phenotype is highly related to that of individuals with atypical 15q24 microdeletions, linking SIN3A to this microdeletion syndrome. Brain magnetic resonance imaging showed subtle abnormalities, including corpus callosum hypoplasia and ventriculomegaly. Intriguingly, in vivo functional knockdown of Sin3a led to reduced cortical neurogenesis, altered neuronal identity and aberrant corticocortical projections in the developing mouse brain. Together, our data establish that haploinsufficiency of SIN3A is associated with mild syndromic intellectual disability and that SIN3A can be considered to be a key transcriptional regulator of cortical brain development. PMID:27399968

  15. Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer

    PubMed Central

    Bansal, Nidhi; Petrie, Kevin; Leibovitch, Boris A.; Howell, Louise; Gil, Veronica; Sbirkov, Yordan; Lee, EunJee; Wexler, Joanna; Ariztia, Edgardo V.; Sharma, Rajal; Zhu, Jun; Bernstein, Emily; Zhou, Ming-Ming; Zelent, Arthur; Farias, Eduardo; Waxman, Samuel

    2015-01-01

    Triple negative breast cancer (TNBC) is characterized by a poorly differentiated phenotype and limited treatment options. Aberrant epigenetics in this subtype represent a potential therapeutic opportunity, but a better understanding of the mechanisms contributing to the TNBC pathogenesis is required. The SIN3 molecular scaffold performs a critical role in multiple cellular processes, including epigenetic regulation, and has been identified as a potential therapeutic target. Using a competitive peptide corresponding to the SIN3 interaction domain of MAD (Tat-SID), we investigated the functional consequences of selectively blocking the paired amphipathic α-helix (PAH2) domain of SIN3. Here, we report the identification of the SID-containing adaptor PF1 as a factor required for maintenance of the TNBC stem cell phenotype and epithelial-to-mesenchymal transition (EMT). Tat-SID peptide blocked the interaction between SIN3A and PF1, leading to epigenetic modulation and transcriptional downregulation of TNBC stem cell and EMT markers. Importantly, Tat-SID treatment also led to a reduction in primary tumor growth and disseminated metastatic disease in vivo. In support of these findings, knockdown of PF1 expression phenocopied treatment with Tat-SID both in vitro and in vivo. These results demonstrate a critical role for a complex containing SIN3A and PF1 in TNBC and provide a rational for its therapeutic targeting. PMID:26460951

  16. Impacts of SiN passivation on the degradation modes of AlGaN/GaN high electron mobility transistors under reverse-bias stress

    SciTech Connect

    Chen, Wei-Wei; Ma, Xiao-Hua E-mail: yhao@xidian.edu.cn; Hou, Bin; Zhu, Jie-Jie; Chen, Yong-He; Zheng, Xue-Feng; Zhang, Jin-Cheng; Hao, Yue E-mail: yhao@xidian.edu.cn

    2014-10-27

    Impacts of SiN passivation on the degradation modes of AlGaN/GaN high electron mobility transistors are investigated. The gate leakage current decreases significantly upon removing the SiN layer and no clear critical voltage for the sudden degradation of the gate leakage current can be observed in the reverse-bias step-stress experiments. Gate-lag measurements reveal the decrease of the fast-state surface traps and the increase of slow-state traps after the passivation layer removal. It is postulated that consistent surface charging relieves the electric field peak on the gate edge, thus the inverse piezoelectric effect is shielded.

  17. Seven Survey Sins

    ERIC Educational Resources Information Center

    Gehlbach, Hunter

    2015-01-01

    As pressure builds to assess students, teachers, and schools, educational practitioners and policy makers are increasingly looking toward student perception surveys as a promising means to collect high-quality, useful data. For instance, the widely cited Measures of Effective Teaching study lists student perception surveys as one of the three key…

  18. THE SINS/zC-SINF SURVEY OF z {approx} 2GALAXY KINEMATICS: THE NATURE OF DISPERSION-DOMINATED GALAXIES

    SciTech Connect

    Newman, Sarah F.; Genzel, Reinhard; Foerster Schreiber, Natascha M.; Buschkamp, Peter; Davies, Ric; Eisenhauer, Frank; Kurk, Jaron; Lutz, Dieter; Shapiro Griffin, Kristen; Mancini, Chiara; Renzini, Alvio; Lilly, Simon J.; Carollo, C. Marcella; Peng, Yingjie; Bouche, Nicolas; Burkert, Andreas; Cresci, Giovanni; Genel, Shy; Hicks, Erin K. S.; Naab, Thorsten; and others

    2013-04-20

    We analyze the spectra, spatial distributions, and kinematics of H{alpha}, [N II], and [S II] emission in a sample of 38, z {approx} 2.2 UV/optically selected star-forming galaxies (SFGs) from the SINS and zC-SINF surveys, 34 of which were observed in the adaptive optics mode of SINFONI and 30 of those contain data presented for the first time here. This is supplemented by kinematic data from 43 z {approx} 1-2.5 galaxies from the literature. None of these 81 galaxies is an obvious major merger. We find that the kinematic classification of high-z SFGs as ''dispersion dominated'' or ''rotation dominated'' correlates most strongly with their intrinsic sizes. Smaller galaxies are more likely ''dispersion-dominated'' for two main reasons: (1) the rotation velocity scales linearly with galaxy size but intrinsic velocity dispersion does not depend on size or may even increase in smaller galaxies, and as such, their ratio is systematically lower for smaller galaxies, and (2) beam smearing strongly decreases large-scale velocity gradients and increases observed dispersion much more for galaxies with sizes at or below the resolution. Dispersion-dominated SFGs may thus have intrinsic properties similar to ''rotation-dominated'' SFGs, but are primarily more compact, lower mass, less metal enriched, and may have higher gas fractions, plausibly because they represent an earlier evolutionary state.

  19. Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.

    PubMed

    Rampalli, Shravanti; Pavithra, L; Bhatt, Altaf; Kundu, Tapas K; Chattopadhyay, Samit

    2005-10-01

    Matrix attachment region binding proteins have been shown to play an important role in gene regulation by altering chromatin in a stage- and tissue-specific manner. Our previous studies report that SMAR1, a matrix-associated protein, regresses B16-F1-induced tumors in mice. Here we show SMAR1 targets the cyclin D1 promoter, a gene product whose dysregulation is attributed to breast malignancies. Our studies reveal that SMAR1 represses cyclin D1 gene expression, which can be reversed by small interfering RNA specific to SMAR1. We demonstrate that SMAR1 interacts with histone deacetylation complex 1, SIN3, and pocket retinoblastomas to form a multiprotein repressor complex. This interaction is mediated by the SMAR1(160-350) domain. Our data suggest SMAR1 recruits a repressor complex to the cyclin D1 promoter that results in deacetylation of chromatin at that locus, which spreads to a distance of at least the 5 kb studied upstream of the cyclin D1 promoter. Interestingly, we find that the high induction of cyclin D1 in breast cancer cell lines can be correlated to the decreased levels of SMAR1 in these lines. Our results establish the molecular mechanism exhibited by SMAR1 to regulate cyclin D1 by modification of chromatin. PMID:16166625

  20. Population density and seasonality effects on Sin Nombre virus transmission in North American deermice (Peromyscus maniculatus) in outdoor enclosures.

    PubMed

    Bagamian, Karoun H; Douglass, Richard J; Alvarado, Arlene; Kuenzi, Amy J; Amman, Brian R; Waller, Lance A; Mills, James N

    2012-01-01

    Surveys of wildlife host-pathogen systems often document clear seasonal variation in transmission; conclusions concerning the relationship between host population density and transmission vary. In the field, effects of seasonality and population density on natural disease cycles are challenging to measure independently, but laboratory experiments may poorly reflect what happens in nature. Outdoor manipulative experiments are an alternative that controls for some variables in a relatively natural environment. Using outdoor enclosures, we tested effects of North American deermouse (Peromyscus maniculatus) population density and season on transmission dynamics of Sin Nombre hantavirus. In early summer, mid-summer, late summer, and fall 2007-2008, predetermined numbers of infected and uninfected adult wild deermice were released into enclosures and trapped weekly or bi-weekly. We documented 18 transmission events and observed significant seasonal effects on transmission, wounding frequency, and host breeding condition. Apparent differences in transmission incidence or wounding frequency between high- and low-density treatments were not statistically significant. However, high host density was associated with a lower proportion of males with scrotal testes. Seasonality may have a stronger influence on disease transmission dynamics than host population density, and density effects cannot be considered independent of seasonality.

  1. pSIN: A scalable, Parallel algorithm for Seismic INterferometry of large-N ambient-noise data

    NASA Astrophysics Data System (ADS)

    Chen, Po; Taylor, Nicholas J.; Dueker, Ken G.; Keifer, Ian S.; Wilson, Andra K.; McGuffy, Casey L.; Novitsky, Christopher G.; Spears, Alec J.; Holbrook, W. Steven

    2016-08-01

    Seismic interferometry is a technique for extracting deterministic signals (i.e., ambient-noise Green's functions) from recordings of ambient-noise wavefields through cross-correlation and other related signal processing techniques. The extracted ambient-noise Green's functions can be used in ambient-noise tomography for constructing seismic structure models of the Earth's interior. The amount of calculations involved in the seismic interferometry procedure can be significant, especially for ambient-noise datasets collected by large seismic sensor arrays (i.e., "large-N" data). We present an efficient parallel algorithm, named pSIN (Parallel Seismic INterferometry), for solving seismic interferometry problems on conventional distributed-memory computer clusters. The design of the algorithm is based on a two-dimensional partition of the ambient-noise data recorded by a seismic sensor array. We pay special attention to the balance of the computational load, inter-process communication overhead and memory usage across all MPI processes and we minimize the total number of I/O operations. We have tested the algorithm using a real ambient-noise dataset and obtained a significant amount of savings in processing time. Scaling tests have shown excellent strong scalability from 80 cores to over 2000 cores.

  2. A lethal disease model for hantavirus pulmonary syndrome in immunosuppressed Syrian hamsters infected with Sin Nombre virus.

    PubMed

    Brocato, Rebecca L; Hammerbeck, Christopher D; Bell, Todd M; Wells, Jay B; Queen, Laurie A; Hooper, Jay W

    2014-01-01

    Sin Nombre virus (SNV) is a rodent-borne hantavirus that causes hantavirus pulmonary syndrome (HPS) predominantly in North America. SNV infection of immunocompetent hamsters results in an asymptomatic infection; the only lethal disease model for a pathogenic hantavirus is Andes virus (ANDV) infection of Syrian hamsters. Efforts to create a lethal SNV disease model in hamsters by repeatedly passaging virus through the hamster have demonstrated increased dissemination of the virus but no signs of disease. In this study, we demonstrate that immunosuppression of hamsters through the administration of a combination of dexamethasone and cyclophosphamide, followed by infection with SNV, results in a vascular leak syndrome that accurately mimics both HPS disease in humans and ANDV infection of hamsters. Immunosuppressed hamsters infected with SNV have a mean number of days to death of 13 and display clinical signs associated with HPS, including pulmonary edema. Viral antigen was widely detectable throughout the pulmonary endothelium. Histologic analysis of lung sections showed marked inflammation and edema within the alveolar septa of SNV-infected hamsters, results which are similar to what is exhibited by hamsters infected with ANDV. Importantly, SNV-specific neutralizing polyclonal antibody administered 5 days after SNV infection conferred significant protection against disease. This experiment not only demonstrated that the disease was caused by SNV, it also demonstrated the utility of this animal model for testing candidate medical countermeasures. This is the first report of lethal disease caused by SNV in an adult small-animal model.

  3. Dynamics of a surface-modified miniaturized SiN mechanical resonator via a nanometer-scale pore array.

    PubMed

    Lee, Eun Joong; Cho, Myung Rae; Kim, Seunghwan; Park, Yun Daniel; Kouh, Taejoon

    2016-05-13

    We have fabricated porous miniaturized SiN resonators with various dimensions and studied their mechanical dynamics at their resonant modes. The surface modification of the resonators has been achieved by etching through a thin porous anodic aluminum oxide (AAO) mask, prepared by two-step anodization. Even though these porous resonators show well-defined Lorentzian line-shapes at their resonant modes, the corresponding fundamental flexural resonance frequencies are lower than those from typical non-porous resonators. The change in the resonance frequency is due to the presence of the pores on the surface, which reduces the effective tensile stress across the beam structure, as shown from both experimental measurements and the computational model. In addition, the observed quality factor reveals the level of dissipation originating from the surface modification. The principal dissipation mechanism is found to be gas damping in the free molecular flow regime. Based on the dissipation measurement, one can see an increase in the surface-to-mass ratio, which is responsible for the increased dissipation in the porous beam structure. The work presented here demonstrates simple integration of mechanical elements with a nanopatterning technique based on an AAO as well as the tuning of mechanics via surface modification at a small scale. Such a scheme could provide an additional degree of freedom in developing a mechanical sensing element with enhanced effective surface area. PMID:27039942

  4. Al Incorporation at All Growth Stages of Al x Ga1- x N Epilayers Using SiN Treatment

    NASA Astrophysics Data System (ADS)

    Benzarti, Z.; Halidou, I.; Touré, A.; El Jani, B.

    2016-02-01

    Al compositional distribution of Al x Ga1- x N epilayers grown on SiN-treated sapphire substrate by atmospheric pressure metalorganic vapor phase epitaxy is investigated. The growth process was interrupted at various stages allowing a systematic study of Al x Ga1- x N epilayers during the smoothing process. A transition from three-dimensional (3D) to two-dimensional (2D) growth mode is revealed by in situ laser reflectometry (λ = 632.8 nm) as well as by atomic force microscopic images. Then, ion mass spectrometry analysis was performed to obtain the solid Al composition ( x) profile as well as by photoluminescence measurements. Moreover, the in situ reflectivity signal is simulated; thereby Al x Ga1- x N growth rate is derived and compared with that of GaN layer in order to study the effect of the aluminum incorporation on the growth mechanism. It is worth emphasising that the growth mode of Al x Ga1- x N layers is dictated by SiN treatment, which influences the Al compositional distribution. Electron mobility and refractive index against the thickness of Al x Ga1- x N layers have similar trends, which confirm a competitive mechanism between growth mode and Al incorporation. Therefore, the correlation between the Al composition and morphological, optical, and electrical properties of Al x Ga1- x N layers is established.

  5. An array of cold-electron bolometers with SIN tunnel junctions and JFET readout for cosmology instruments

    NASA Astrophysics Data System (ADS)

    Kuzmin, L.

    2008-02-01

    A novel concept of the parallel/series array of Cold-Electron Bolometers (CEB) with Superconductor-Insulator-Normal (SIN) Tunnel Junctions has been proposed. The concept was developed specially for matching the CEB with JFET amplifier at conditions of high optical power load. The CEB is a planar antenna-coupled superconducting detector with high sensitivity. For combination of effective HF operation and low noise properties the current-biased CEBs are connected in series for DC and in parallel for HF signal. A signal is concentrated from an antenna to the absorber through the capacitance of the tunnel junctions and through additional capacitance for coupling of superconducting islands. Using array of CEBs the applications can be considerably extended to higher power load by distributing the power between N CEBs and decreasing the electron temperature. Due to increased responsivity the noise matching is so effective that photon NEP could be easily achieved at 300 mK with a room temperature JFET for wide range of optical power loads. The concept of the CEB array has been developed for the BOOMERanG balloon telescope and other Cosmology instruments.

  6. High-temperature ultraviolet detection based on surface photovoltage effect in SiN passivated n-GaN films

    NASA Astrophysics Data System (ADS)

    Matys, M.; Adamowicz, B.; Zytkiewicz, Z. R.; Taube, A.; Kruszka, R.; Piotrowska, A.

    2016-08-01

    We investigated the surface photovoltage (SPV) effect in n-GaN layers passivated with various insulators, i.e., Al2O3, SiO2, and SiN for ultraviolet (UV) light detection. We revealed that SPV in SiN/GaN shows markedly different behaviour than in oxide/GaN, i.e., the photo-signal exhibited very fast response (1 s) and recovery (2 s) times, contrary to oxide/GaN, and it was thermally stable up to 523 K. Furthermore, SPV spectra for SiN/GaN showed a sharp cut-off edge directly corresponding to the GaN band gap. We explained these results in terms of the different band structure of SiN/GaN and oxide/GaN junctions. All the observed properties of SPV response from SiN/GaN indicate that this relatively simple system can be applied to sensitive high temperature visible-blind UV detection.

  7. Dynamics of a surface-modified miniaturized SiN mechanical resonator via a nanometer-scale pore array

    NASA Astrophysics Data System (ADS)

    Lee, Eun Joong; Cho, Myung Rae; Kim, Seunghwan; Park, Yun Daniel; Kouh, Taejoon

    2016-05-01

    We have fabricated porous miniaturized SiN resonators with various dimensions and studied their mechanical dynamics at their resonant modes. The surface modification of the resonators has been achieved by etching through a thin porous anodic aluminum oxide (AAO) mask, prepared by two-step anodization. Even though these porous resonators show well-defined Lorentzian line-shapes at their resonant modes, the corresponding fundamental flexural resonance frequencies are lower than those from typical non-porous resonators. The change in the resonance frequency is due to the presence of the pores on the surface, which reduces the effective tensile stress across the beam structure, as shown from both experimental measurements and the computational model. In addition, the observed quality factor reveals the level of dissipation originating from the surface modification. The principal dissipation mechanism is found to be gas damping in the free molecular flow regime. Based on the dissipation measurement, one can see an increase in the surface-to-mass ratio, which is responsible for the increased dissipation in the porous beam structure. The work presented here demonstrates simple integration of mechanical elements with a nanopatterning technique based on an AAO as well as the tuning of mechanics via surface modification at a small scale. Such a scheme could provide an additional degree of freedom in developing a mechanical sensing element with enhanced effective surface area.

  8. Paleoenvironmental reconstruction based on palynofacies analyses of the Cansona Formation (Late Cretaceous), Sinú-San Jacinto Basin, northwest Colombia

    NASA Astrophysics Data System (ADS)

    Juliao-Lemus, Tatiana; Carvalho, Marcelo de Araujo; Torres, Diego; Plata, Angelo; Parra, Carlos

    2016-08-01

    To reconstruct the paleoenvironments of the Cansona Formation, a Cretaceous succession in Colombia that has controversial paleoenvironmental interpretation, occasionally deep marine and occasionally shallow marine, palynofacies analyses were conducted on 93 samples from four sections of the Sinú San Jacinto Basin in the north, midwest, and southwest sectors. For the palynofacies analyses, the kerogen categories were counted and subjected to cluster analyses. Four palynofacies associations were revealed for the four sections: Palynofacies Association I (PA I), which consisted of microforaminiferal linings, scolecodonts, dinoflagellate cysts, pollen grains, and fungi hyphae; PA II, which consisted of phytoclast translucent non-biostructured and biostructured, opaque phytoclasts (equidimensional and lath shaped); PA III, which consisted of pseudoamorphous particles, cuticles, resin, and fungal spores; and PA IV, which consisted of fluorescent and non-fluorescent amorphous organic matter and the fresh-water algae Botryococcus. In contrast to early studies that suggested a generalization of the depositional environment for the Cansona Formation (deep or shallow conditions), this study suggests that the formation reflects conspicuous stratigraphic and lateral changes and hence different depositional environments. The Cerro Cansona (CC4 section) and Chalán (AP section) areas are a more marine proximal settings (Early Campanian-Maastrichtian), and there is an intermediate setting for the Lorica area (SC section) and deeper conditions for the Montería area (CP2 section).

  9. Consuming English: How Mexican Transmigrants form Identities and Construct Symbolic Citizenship through the English-Language Program Ingles Sin Barreras [English without Barriers

    ERIC Educational Resources Information Center

    Ullman, Char

    2010-01-01

    "Ingles Sin Barreras" is an English-language program that is highly advertised on Spanish-language television in the United States, to the point that it has become a pop-culture phenomenon. In this article, I argue that few people actually use it to learn English, but instead consume it as a symbol of national belonging. This article puts…

  10. Evidence That the Transcriptional Regulators Sin3 and Rpd3, and a Novel Gene (Sds3) with Similar Functions, Are Involved in Transcriptional Silencing in S. Cerevisiae

    PubMed Central

    Vannier, D.; Balderes, D.; Shore, D.

    1996-01-01

    In a screen for extragenic suppressors of a silencing defective rap1(s) hmrΔA strain, recessive mutations in 21 different genes were found that restored repression to HMR. We describe the characterization of three of these SDS (suppressors of defective silencing) genes. SDS16 and SDS6 are known transcriptional modifiers, SIN3(RPD1/UME4/SDI1/GAM2) and RPD3(SDI2), respectively, while the third is a novel gene, SDS3. SDS3 shares the meiotic functions of SIN3 and RPD3 in that it represses IME2 in haploid cells and is necessary for sporulation in diploid cells. However, sds3 mutations differ from sin3 and rpd3 mutations in that they do not derepress TRK2. These sds mutations suppress a variety of cis- and trans-defects, which impair the establishment of silencing at HMR. Any one of the sds mutations slightly increases telomere position effect while a striking synergistic increase in repression is observed in a rap1(s) background. Epistasis studies suggest that SDS3 works in a different pathway from RPD3 and SIN3 to affect silencing at HMR. Together these results show that defects in certain general transcriptional modifiers can have a pronounced influence on position-effect gene silencing in yeast. Mechanisms for this increase in postion effect are discussed. PMID:8978024

  11. Top-gated graphene field-effect transistors by low-temperature synthesized SiN x insulator on SiC substrates

    NASA Astrophysics Data System (ADS)

    Ohno, Yasuhide; Kanai, Yasushi; Mori, Yuki; Nagase, Masao; Matsumoto, Kazuhiko

    2016-06-01

    Top-gated devices made from an epitaxial graphene film on a 4H-SiC substrate were fabricated. Atomic force microscopy and Raman spectroscopy results showed that a large-scale highly uniform monolayer graphene film was synthesized on the SiC substrate. A SiN x passivation film was deposited on a SiC graphene device as a top gate insulator by catalytic chemical-vapor deposition (Cat-CVD) below 65 °C. After the top gate electrode was formed on the SiN x film, no leakage current flowed between the gate and source electrodes. The transport characteristics showed clear ambipolar characteristics from 8 to 280 K, and the temperature dependences of the conductance and field-effect mobility of the devices implied that monolayer graphene devices can be successfully fabricated. Moreover, the position of the charge neutrality point after SiN x deposition was around 0 V, indicating p-doping characteristics. These results indicate that SiN x films synthesized by Cat-CVD can be used as gate insulators and that the carrier type may be controlled by adjusting the deposition conditions.

  12. A robust and accurate center-frequency estimation (RACE) algorithm for improving motion estimation performance of SinMod on tagged cardiac MR images without known tagging parameters.

    PubMed

    Liu, Hong; Wang, Jie; Xu, Xiangyang; Song, Enmin; Wang, Qian; Jin, Renchao; Hung, Chih-Cheng; Fei, Baowei

    2014-11-01

    A robust and accurate center-frequency (CF) estimation (RACE) algorithm for improving the performance of the local sine-wave modeling (SinMod) method, which is a good motion estimation method for tagged cardiac magnetic resonance (MR) images, is proposed in this study. The RACE algorithm can automatically, effectively and efficiently produce a very appropriate CF estimate for the SinMod method, under the circumstance that the specified tagging parameters are unknown, on account of the following two key techniques: (1) the well-known mean-shift algorithm, which can provide accurate and rapid CF estimation; and (2) an original two-direction-combination strategy, which can further enhance the accuracy and robustness of CF estimation. Some other available CF estimation algorithms are brought out for comparison. Several validation approaches that can work on the real data without ground truths are specially designed. Experimental results on human body in vivo cardiac data demonstrate the significance of accurate CF estimation for SinMod, and validate the effectiveness of RACE in facilitating the motion estimation performance of SinMod.

  13. Structural stability and Sin a 1 anti-epitope antibody binding ability of yellow mustard (Sinapis alba L.) napin during industrial-scale myrosinase inactivation process.

    PubMed

    Marambe, Harsha K; McIntosh, Tara C; Cheng, Bifang; Wanasundara, Janitha P D

    2015-07-01

    This study investigated the structural stability of yellow mustard (YM, Sinapis alba L.) napin and the changes of its Sin a 1 anti-epitope antibody-binding ability during myrosinase enzyme inactivation process. The food industry uses myrosinase-inactive non-pungent YM for uses beyond spice applications. Napin was isolated from seeds received from an industrial processor before (YM + M) and after (YM - M) myrosinase inactivation. Secondary and tertiary structural features and surface hydrophobicity parameters of napin were analyzed. The Sin a 1 content in YM seeds and the stability of Sin a 1-containing napin during simulated in vitro gastrointestinal (GI) digestion were determined by a non-competitive indirect enzyme-linked immunosorbent assay using the Sin a 1 anti-epitope antibody (AE-Ab) as the primary Ab. YM napin retained the dominant alpha-helical components of secondary and tertiary structure folds during this process. YM - M napin showed changes in hydrophobicity parameters of the molecules and binding ability of AE-Ab: 2.19 ± 0.48 g per 100 g of YM - M seeds vs. 1.49 ± 0.16 g per 100 g YM + M seeds. YM - M proteins were more susceptible for in vitro GI digestion and also showed a 30% reduction in AE-Ab binding ability upon digestion of napins. This suggests that the myrosinase inactivation process has induced the surface modification of napin, exposing Sin a 1 epitope, leading to an increase in AE-Ab binding. However, the epitope region of YM - M napin showed improved susceptibility for hydrolysis during GI digestion resulting in fewer available epitope regions, suggesting a possible reduction in napin immune reactivity. PMID:26091085

  14. Structural stability and Sin a 1 anti-epitope antibody binding ability of yellow mustard (Sinapis alba L.) napin during industrial-scale myrosinase inactivation process.

    PubMed

    Marambe, Harsha K; McIntosh, Tara C; Cheng, Bifang; Wanasundara, Janitha P D

    2015-07-01

    This study investigated the structural stability of yellow mustard (YM, Sinapis alba L.) napin and the changes of its Sin a 1 anti-epitope antibody-binding ability during myrosinase enzyme inactivation process. The food industry uses myrosinase-inactive non-pungent YM for uses beyond spice applications. Napin was isolated from seeds received from an industrial processor before (YM + M) and after (YM - M) myrosinase inactivation. Secondary and tertiary structural features and surface hydrophobicity parameters of napin were analyzed. The Sin a 1 content in YM seeds and the stability of Sin a 1-containing napin during simulated in vitro gastrointestinal (GI) digestion were determined by a non-competitive indirect enzyme-linked immunosorbent assay using the Sin a 1 anti-epitope antibody (AE-Ab) as the primary Ab. YM napin retained the dominant alpha-helical components of secondary and tertiary structure folds during this process. YM - M napin showed changes in hydrophobicity parameters of the molecules and binding ability of AE-Ab: 2.19 ± 0.48 g per 100 g of YM - M seeds vs. 1.49 ± 0.16 g per 100 g YM + M seeds. YM - M proteins were more susceptible for in vitro GI digestion and also showed a 30% reduction in AE-Ab binding ability upon digestion of napins. This suggests that the myrosinase inactivation process has induced the surface modification of napin, exposing Sin a 1 epitope, leading to an increase in AE-Ab binding. However, the epitope region of YM - M napin showed improved susceptibility for hydrolysis during GI digestion resulting in fewer available epitope regions, suggesting a possible reduction in napin immune reactivity.

  15. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation

    PubMed Central

    Das, Amlan; Gopalakrishnan, Bhavani; Druhan, Lawrence J; Wang, Tse-Yao; De Pascali, Francesco; Rockenbauer, Antal; Racoma, Ira; Varadharaj, Saradhadevi; Zweier, Jay L; Cardounel, Arturo J; Villamena, Frederick A

    2014-01-01

    Background and Purpose Nitric oxide (NO) derived from eNOS is mostly responsible for the maintenance of vascular homeostasis and its decreased bioavailability is characteristic of reactive oxygen species (ROS)-induced endothelial dysfunction (ED). Because 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), a commonly used spin trap, can control intracellular nitroso-redox balance by scavenging ROS and donating NO, it was employed as a cardioprotective agent against ED but the mechanism of its protection is still not clear. This study elucidated the mechanism of protection by DMPO against SIN-1-induced oxidative injury to bovine aortic endothelial cells (BAEC). Experimental Approach BAEC were treated with SIN-1, as a source of peroxynitrite anion (ONOO−), and then incubated with DMPO. Cytotoxicity following SIN-1 alone and cytoprotection by adding DMPO was assessed by MTT assay. Levels of ROS and NO generation from HEK293 cells transfected with wild-type and mutant eNOS cDNAs, tetrahydrobiopterin bioavailability, eNOS activity, eNOS and Akt kinase phosphorylation were measured. Key Results Post-treatment of cells with DMPO attenuated SIN-1-mediated cytotoxicity and ROS generation, restoration of NO levels via increased in eNOS activity and phospho-eNOS levels. Treatment with DMPO alone significantly increased NO levels and induced phosphorylation of eNOS Ser1179 via Akt kinase. Transfection studies with wild-type and mutant human eNOS confirmed the dual role of eNOS as a producer of superoxide anion (O2−) with SIN-1 treatment, and a producer of NO in the presence of DMPO. Conclusion and Implications Post-treatment with DMPO of oxidatively challenged cells reversed eNOS dysfunction and could have pharmacological implications in the treatment of cardiovascular diseases. PMID:24405159

  16. Study of Rare B-Meson Decays Related to the CPObservable sin(2beta+gamma) at the BABAR Experiment

    SciTech Connect

    Orimoto, Toyoko Jennifer

    2006-01-01

    This study reports the observation of the decays B0→D$*+\\atop{s}$π- and B0→D(*)-K+ in a sample of 230 x 106 Y(4S) → B$\\bar{B}$ events collected with the BABAR detector at the PEP-II asymmetric-energy e+e- storage ring, located at the Stanford Linear Accelerator Center. The branching fractions β(B0 → D$+\\atop{S}$π-) = (1.3 ± 0.3 (stat) ± 0.2 (syst)) x 10-5, β(B0 → D$+\\atop{S}$K+) = (2.5 ± 0.4 (stat) ± 0.4 (syst)) x 10-5, β(B0→D$*+\\atop{s}$π-) = (2.8 ± 0.6 (stat) ± 0.5 (syst)) x 10-5, and β(B0→D(*)-K+) = (2.0 ± 0.5 (stat) ± 0.4 (syst)) x 10-5 are measured. The significance of the measurements to differ from zero are 5, 9, 6, and 5 standard deviations, respectively. This is a first observation of the decaysB+→D$*+\\atop{s}$π- and B0→D(*)-K+. These results may potentially be useful in determining the CP asymmetry parameter sin(2β + γ) in the decays B0→D$*+\\atop{s}$π-.

  17. The SINS/zC-SINF survey of z ∼ 2 galaxy kinematics: Evidence for gravitational quenching

    SciTech Connect

    Genzel, R.; Förster Schreiber, N. M.; Lang, P.; Tacconi, L. J.; Wuyts, S.; Bandara, K.; Burkert, A.; Buschkamp, P.; Davies, R.; Eisenhauer, F.; Kurk, J.; Lutz, D.; Tacchella, S.; Carollo, C. M.; Lilly, S. J.; Cresci, G.; Hicks, E. K. S.; Mancini, C.; Naab, T.; Newman, S.; and others

    2014-04-10

    As part of the SINS/zC-SINF surveys of high-z galaxy kinematics, we derive the radial distributions of Hα surface brightness, stellar mass surface density, and dynamical mass at ∼2 kpc resolution in 19 z ∼ 2 star-forming disks with deep SINFONI adaptive optics spectroscopy at the ESO Very Large Telescope. From these data we infer the radial distribution of the Toomre Q-parameter for these main-sequence star-forming galaxies (SFGs), covering almost two decades of stellar mass (10{sup 9.6}-10{sup 11.5} M {sub ☉}). In more than half of our SFGs, the Hα distributions cannot be fit by a centrally peaked distribution, such as an exponential, but are better described by a ring, or the combination of a ring and an exponential. At the same time the kinematic data indicate the presence of a mass distribution more centrally concentrated than a single exponential distribution for 5 of the 19 galaxies. The resulting Q-distributions are centrally peaked for all, and significantly exceed unity there for three-quarters of the SFGs. The occurrence of Hα rings and of large nuclear Q-values appears to be more common for the more massive SFGs. While our sample is small and biased to larger SFGs, and there remain uncertainties and caveats, our observations are consistent with a scenario in which cloud fragmentation and global star formation are secularly suppressed in gas-rich high-z disks from the inside out, as the central stellar mass density of the disks grows.

  18. DNA–PKcs–SIN1 complexation mediates low-dose X-ray irradiation (LDI)-induced Akt activation and osteoblast differentiation

    SciTech Connect

    Xu, Yong; Fang, Shi-ji; Zhu, Li-juan; Zhu, Lun-qing; Zhou, Xiao-zhong

    2014-10-24

    Highlights: • LDI increases ALP activity, promotes type I collagen (Col I)/Runx2 mRNA expression. • LDI induces DNA–PKcs activation, which is required for osteoblast differentiation. • Akt activation mediates LDI-induced ALP activity and Col I/Runx2 mRNA increase. • DNA–PKcs–SIN1 complexation mediates LDI-induced Akt Ser-473 phosphorylation. • DNA–PKcs–SIN1 complexation is important for osteoblast differentiation. - Abstract: Low-dose irradiation (LDI) induces osteoblast differentiation, however the underlying mechanisms are not fully understood. In this study, we explored the potential role of DNA-dependent protein kinase catalytic subunit (DNA–PKcs)–Akt signaling in LDI-induced osteoblast differentiation. We confirmed that LDI promoted mouse calvarial osteoblast differentiation, which was detected by increased alkaline phosphatase (ALP) activity as well as mRNA expression of type I collagen (Col I) and runt-related transcription factor 2 (Runx2). In mouse osteoblasts, LDI (1 Gy) induced phosphorylation of DNA–PKcs and Akt (mainly at Ser-473). The kinase inhibitors against DNA–PKcs (NU-7026 and NU-7441) or Akt (LY294002, perifosine and MK-2206), as well as partial depletion of DNA–PKcs or Akt1 by targeted-shRNA, dramatically inhibited LDI-induced Akt activation and mouse osteoblast differentiation. Further, siRNA-knockdown of SIN1, a key component of mTOR complex 2 (mTORC2), also inhibited LDI-induced Akt Ser-473 phosphorylation as well as ALP activity increase and Col I/Runx2 expression in mouse osteoblasts. Co-immunoprecipitation (Co-IP) assay results demonstrated that LDI-induced DNA–PKcs–SIN1 complexation, which was inhibited by NU-7441 or SIN1 siRNA-knockdown in mouse osteoblasts. In summary, our data suggest that DNA–PKcs–SIN1 complexation-mediated Akt activation (Ser-473 phosphorylation) is required for mouse osteoblast differentiation.

  19. Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models.

    PubMed

    Conforti, Paola; Zuccato, Chiara; Gaudenzi, Germano; Ieraci, Alessandro; Camnasio, Stefano; Buckley, Noel J; Mutti, Cesare; Cotelli, Franco; Contini, Alessandro; Cattaneo, Elena

    2013-10-01

    Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowing expressing of REST target genes. Here, we aimed to identify HTT mimetics that disrupt REST complex formation in HD. From a structure-based virtual screening of 7 million molecules, we selected 94 compounds predicted to interfere with REST complex formation by targeting the PAH1 domain of mSIN3b. Primary screening using DiaNRSELuc8 cells revealed two classes of compounds causing a greater than two-fold increase in luciferase. In particular, quinolone-like compound 91 (C91) at a non-toxic nanomolar concentration reduced mSIN3b nuclear entry and occupancy at the RE1/NRSE within the Bdnf locus, and restored brain-derived neurotrophic factor (BDNF) protein levels in HD cells. The mRNA levels of other RE1/NRSE-regulated genes were similarly increased while non-REST-regulated genes were unaffected. C91 stimulated REST-regulated gene expression in HTT-knockdown Zebrafish and increased BDNF mRNA in the presence of mutant HTT. Thus, a combination of virtual screening and biological approaches can lead to compounds reducing REST complex formation, which may be useful in HD and in other pathological conditions. PMID:23800350

  20. A computational investigation of electronic structure as well as 19F and 29Si chemical shielding tensors in the fluorinated silicon fullerenes SinFn (n≤60)

    NASA Astrophysics Data System (ADS)

    Anafcheh, Maryam; Ghafouri, Reza

    2013-02-01

    Density functional theory (DFT) calculations are performed to investigate the electronic features of the structures of fluorinated polysilanes SinFn (n=4, 6, 8, 10, 12, 20, 24, 28, 30, 32, 36, 50, and 60). Among all of these fluorinated polysilanes, Si20F20 has the highest binding energy and, thus, stability. The binding energy then shows a very slow (monotonically) decrease as the size of the fluorinated silicon fullerene n≥20 increases which can be related to an increase in fluorine-fluorine repulsion. Following an irregular pattern, the HOMO-LUMO energy gap strongly depends on the size of the cage. On the other hand, 29Si CS parameters detect equivalent electronic environment for silicon atoms within SinHn polysilanes with n≤20 while 29Si NMR pattern indicates a few separated peaks for SinHn polysilanes with n≥20. Seeking correlation between these peaks and local structures around silicon sites, Siα, Siβ, Siγ observed in these models shows that δiso(Siγ)<δiso(Siβ) <δiso(Siα). Obtaining similar values (458.8-478.7 ppm) of 19F calculated chemical shieldings for all the fluorinated polysilanes means the same tendency of the silicon atoms on the surfaces of all cages for contribution to chemical bonding with fluorine atoms.

  1. Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric oxide generation and protein nitration: ameliorative effect against apoptosis mediated neuronal cell damage.

    PubMed

    Hemanth Kumar, Kandikattu; Tamatam, Anand; Pal, Ajay; Khanum, Farhath

    2013-01-01

    Nitrosylation of tyrosine (3-nitro tyrosine, 3-NT) has been implicated in the pathophysiology of various disorders particularly neurodegenerative conditions and aging. Cyperus rotundus rhizome is being used as a traditional folk medicine to alleviate a variety of disorders including neuronal stress. The herb has recently found applications in food and confectionary industries also. In current study, we have explored the protective effects of C. rotundus rhizome extract (CRE) through its oxido-nitrosative and anti apoptotic mechanism to attenuate peroxynitrite (ONOO(-)) induced neurotoxicity using human neuroblastoma SH-SY5Y cells. Our results elucidate that pre-treatment of neurons with CRE ameliorates the mitochondrial and plasma membrane damage induced by 500 μM SIN-1 to 80% and 24% as evidenced by MTT and LDH assays. CRE inhibited NO generation by downregulating i-NOS expression. SIN-1 induced depletion of antioxidant enzyme status was also replenished by CRE which was confirmed by immunoblot analysis of SOD and CAT. The CRE pre-treatment efficiently potentiated the SIN-1 induced apoptotic biomarkers such as bcl-2 and caspase-3 which orchestrate the proteolytic damage of the cell. The ONOO(-) induced damage to cellular, nuclear and mitochondrial integrity was also restored by CRE. Furthermore, CRE pre-treatment also regulated the 3-NT formation which shows the potential of plant extract against tyrosine nitration. Taken together, our findings suggest that CRE might be developed as a preventive agent against ONOO(-) induced apoptosis. PMID:23174672

  2. SlrA/SlrR/SinR inhibits motility gene expression upstream of a hypersensitive and hysteric switch at the level of σD in Bacillus subtilis

    PubMed Central

    Cozy, Loralyn M.; Phillips, Andrew M.; Calvo, Rebecca A.; Bate, Ashley R.; Hsueh, Yi-Huang; Bonneau, Richard; Eichenberger, Patrick; Kearns, Daniel B.

    2012-01-01

    Exponentially growing Bacillus subtilis cultures are epigenetically differentiated into two subpopulations in which cells are either ON or OFF for σD-dependent gene expression: a pattern suggestive of bistability. The gene encoding σD, sigD, is part of the 31-gene fla/che operon where its location at the 3′ end, 25 kb away from the strong Pfla/che promoter, determines its expression level relative to a threshold. Here we show that addition of a single extra copy of the slrA gene in the chromosome inhibited σD-dependent gene expression. SlrA together with SinR and SlrR reduced sigD transcript by potentiating a distance-dependent decrease in fla/che operon transcript abundance that was not mediated by changes in expression from the Pfla/che promoter. Consistent with acting upstream of σD, SlrA/SinR/SlrR could be bypassed by artificial ectopic expression of sigD that hysteretically maintained for 20 generations by engaging the sigD gene at the native locus. SlrA/SinR/SlrR was also bypassed by increasing fla/che transcription and resulted a hypersensitive output in flagellin expression. Thus, flagellin gene expression demonstrated hypersensitivity and hysteresis and we conclude that σD-dependent gene expression is bistable. PMID:22329926

  3. Broadband antireflection for a high-index substrate using SiN x /SiO2 by inductively coupled plasma chemical vapour deposition

    NASA Astrophysics Data System (ADS)

    Lim, Kim Peng; Ng, Doris K. T.; Wang, Qian

    2016-03-01

    This paper presents the development of broadband antireflection coating for a high-index substrate such as Si using SiN x /SiO2 by inductively coupled plasma chemical vapour deposition (ICP-CVD). The thin-film design employs a simulated annealing method for a minimal average reflectance over the wavelength range and incidence angles involved, which gives the optimized refractive index and thickness of each layer of the thin-film stack under different layer numbers. Using ICP-CVD, the SiN x material system is optimized by tuning the SiH4/N2 gas ratio. The corresponding thin-film characterization shows the precise refractive index/film thickness control in deposition, and the deposited film also has a low absorption coefficient and smooth surface. The double-layer SiN x /SiO2 coating with the optimized refractive index and thickness for broadband antireflection is demonstrated experimentally. The average reflectance of the Si surface is reduced from ~32% to ~3.17% at normal incidence for a wavelength range from 400 to 1100 nm.

  4. Long-range effects of histone point mutations on DNA remodeling revealed from computational analyses of SIN-mutant nucleosome structures

    PubMed Central

    Xu, Fei; Colasanti, Andrew V.; Li, Yun; Olson, Wilma K.

    2010-01-01

    The packaging of DNA into nucleosomes impedes the binding and access of molecules involved in its processing. The SWI/SNF multi-protein assembly, found in yeast, is one of many regulatory factors that stimulate the remodeling of DNA required for its transcription. Amino-acid point mutations in histones H3 or H4 partially bypass the requirement of the SWI/SNF complex in this system. The mechanisms underlying the observed remodeling, however, are difficult to discern from the crystal structures of nucleosomes bearing these so-called SIN (SWI/SNF INdependent) mutations. Here, we report detailed analyses of the conformations and interactions of the histones and DNA in these assemblies. We find that the loss of direct protein–DNA contacts near point-mutation sites, reported previously, is coupled to unexpected additional long-range effects, i.e. loss of intermolecular contacts and accompanying DNA conformational changes at sequentially and spatially distant sites. The SIN mutations seemingly transmit information relevant to DNA binding across the nucleosome. The energetic cost of deforming the DNA to the states found in the SIN-mutant structures helps to distinguish the mutants that show phenotypes in yeast from those that do not. Models incorporating these deformed dimer steps suggest ways that nucleosomal DNA may be remodeled during its biological processing. PMID:20647418

  5. Success and pitfalls of the Sin-2C2H2-C2Bn-2Hn isolobal analogy: Depth and breadth of the boron connection

    NASA Astrophysics Data System (ADS)

    Zdetsis, Aristides D.

    2009-02-01

    The extent and depth of the so-called boron connection suggested recently by the present author [J. Chem. Phys. 128, 184305 (2008)] for the Sin-2C2H2-C2Bn-2Hn isovalent species [following similar connection of (Sin)2--(BnHn)2- dianions] are further investigated by considering larger species up to n =12 and additional isovalent moieties. Here we consider, using density functional and coupled clusters theory, isovalent Sin-2C2H2 and Gen-2C2H2 clusters, in comparison to the corresponding C2Bn-2Hn carboranes and to each other for n =3-8, 12. Special attention is given to the n =8 species, where the corresponding carborane is highly fluxional, and to n =12, where the "parent structures" of the corresponding (Si12)2- and (B12H12)2- dianions have drastically different symmetries. The structures generated by substitutions on (Si12)2-, as well as (B12H12)2-, are compared and interrelated for both C2B10H12 and Si10C2H12. The carborane generated from the Cs (Si12)2- dianion provides an illustrative example of carborane rearrangements, reverting after geometry optimization to the second lowest C2B10H12 meta isomer of C2v symmetry, 0.12 eV above the lowest energy para isomer. This demonstrates the amphidirectional character of the boron connection. It is found that n =8 is the upper limit of the n range in which the isolobal Sin-2C2H2-C2Bn-2Hn analogy is fully operative not only for the lowest but also for the second and third lowest energy states. For n ≤8 all three pairs of structures are isovalent, isostructural, and isolobal. For large values of n (n >8) the boron connection, although not fully isolobal, is still valid in a broader and more general sense, still providing deeper and broader fundamental understanding and insight for both species. It was also found that the Gen-2C2H2 clusters are not fully homologous (isolobal) neither to the isovalent Sin-2C2H2 clusters nor to the corresponding C2Bn-2Hn carboranes, preferring structures in which the two carbon atoms are

  6. Investigaciones sobre cascadas electromagnéticas

    NASA Astrophysics Data System (ADS)

    Orellana, M.; Pellizza, L.; Romero, G. E.

    Results from the latest generations of telescopes have revealed a rich sky at high and very high energies with more than a thousand sources at GeV energies and more than a hundred sources at TeV energies. The sources are galactic and extra-galactic natural particle accelerators where emission processes operate efficiently at the gamma-ray domain. The development of pair-photon cascades within the source or along the line of sight may modify the originally emitted spectrum. This effect should be included in our interpretation of the observations in order to progress in the understanding of the physical origin of the emission. Through numerical simulations; we follow the three-dimensional trajectories of such cascades. I here report on the status of our investigations; with focus on the propagation through the background photon fields. FULL TEXT IN SPANISH

  7. Temporal and geographic evidence for evolution of Sin Nombre virus using molecular analyses of viral RNA from Colorado, New Mexico and Montana

    PubMed Central

    Black, William C; Doty, Jeffrey B; Hughes, Mark T; Beaty, Barry J; Calisher, Charles H

    2009-01-01

    Background All viruses in the family Bunyaviridae possess a tripartite genome, consisting of a small, a medium, and a large RNA segment. Bunyaviruses therefore possess considerable evolutionary potential, attributable to both intramolecular changes and to genome segment reassortment. Hantaviruses (family Bunyaviridae, genus Hantavirus) are known to cause human hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome. The primary reservoir host of Sin Nombre virus is the deer mouse (Peromyscus maniculatus), which is widely distributed in North America. We investigated the prevalence of intramolecular changes and of genomic reassortment among Sin Nombre viruses detected in deer mice in three western states. Methods Portions of the Sin Nombre virus small (S) and medium (M) RNA segments were amplified by RT-PCR from kidney, lung, liver and spleen of seropositive peromyscine rodents, principally deer mice, collected in Colorado, New Mexico and Montana from 1995 to 2007. Both a 142 nucleotide (nt) amplicon of the M segment, encoding a portion of the G2 transmembrane glycoprotein, and a 751 nt amplicon of the S segment, encoding part of the nucleocapsid protein, were cloned and sequenced from 19 deer mice and from one brush mouse (P. boylii), S RNA but not M RNA from one deer mouse, and M RNA but not S RNA from another deer mouse. Results Two of 20 viruses were found to be reassortants. Within virus sequences from different rodents, the average rate of synonymous substitutions among all pair-wise comparisons (πs) was 0.378 in the M segment and 0.312 in the S segment sequences. The replacement substitution rate (πa) was 7.0 × 10-4 in the M segment and 17.3 × 10-4 in the S segment sequences. The low πa relative to πs suggests strong purifying selection and this was confirmed by a Fu and Li analysis. The absolute rate of molecular evolution of the M segment was 6.76 × 10-3 substitutions/site/year. The absolute age of the M segment tree was estimated to

  8. Measurement of time-dependent CP asymmetries and constraints on sin(2beta+gamma) with partial reconstruction of B0-->D*-/+pi+/- decays.

    PubMed

    Aubert, B; Barate, R; Boutigny, D; Couderc, F; Gaillard, J-M; Hicheur, A; Karyotakis, Y; Lees, J P; Robbe, P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; LeClerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Romosan, A; Ronan, M T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Knowles, D J; Morgan, S E; Penny, R C; Watson, A T; Watson, N K; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schmuecker, H; Steinke, M; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; Mackay, C; Wilson, F F; Abe, K; Cuhadar-Donszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; McKemey, A K; Teodorescu, L; Blinov, V E; Bukin, A D; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Kirkby, D; Lankford, A J; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Gary, J W; Layter, J; Shen, B C; Wang, K; del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, Sh; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Beringer, J; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Spradlin, P; Turri, M; Walkowiak, W; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Erwin, R J; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Roy, J; Smith, J G; van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Dubitzky, R S; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, J; Schubert, K R; Schwierz, R; Spaan, B; Wilden, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Grenier, P; Thiebaux, Ch; Vasileiadis, G; Verderi, M; Khan, A; Lavin, D; Muheim, F; Playfer, S; Swain, J E; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Piemontese, L; Sarti, A; Treadwell, E; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Morii, M; Won, E; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Eschrich, I; Gaillard, J R; Morton, G W; Nash, J A; Taylor, G P; Grenier, G J; Lee, S-J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Diberder, F Le; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Brigljević, V; Cheng, C H; Lange, D J; Simani, M C; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, E; Gamet, R; Kay, M; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Harrison, P F; Shorthouse, H W; Vidal, P B; Brown, C L; Cowan, G; Flack, R L; Flaecher, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Hart, P A; Hodgkinson, M C; Jackson, F; Lafferty, G D; Lyon, A J; Weatherall, J H; Williams, J C; Farbin, A; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Staengle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Cote-Ahern, D; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; De Nardo, G; Fabozzi, F; Gatto, C; Lista, L; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; LoSecco, J M; Gabriel, T A; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Wong, Q K; Brau, J; Frey, R; Igonkina, O; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; de la Vaissière, Ch; Del Buono, L; Hamon, O; John, M J J; Leruste, Ph; Ocariz, J; Pivk, M; Roos, L; Stark, J; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Anulli, F; Biasini, M; Peruzzi, I M; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Del Gamba, V; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martinez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lu, C; Miftakov, V; Olsen, J; Smith, A J S; Tanaka, H A; Varnes, E W; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; SafaiTehrani, F; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P-F; Hamel de Monchenault, G; Kozanecki, W; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yeche, Ch; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmueller, O L; Convery, M R; Cristinziani, M; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Elsen, E E; Field, R C; Glanzman, T; Gowdy, S J; Grauges-Pous, E; Hadig, T; Halyo, V; Hryn'ova, T; Innes, W R; Jessop, C P; Kelsey, M H; Kim, P; Kocian, M L; Langenegger, U; Leith, D W G S; Libby, J; Luitz, S; Luth, V; Lynch, H L; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Va'vra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wright, D H; Young, C C; Burchat, P R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, M; Ahmed, S; Alam, M S; Ernst, J A; Saeed, M A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bona, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Johnson, J R; Kutter, P E; Li, H; Liu, R; Di Lodovico, F; Mihalyi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; von Wimmersperg-Toeller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H

    2004-06-25

    We present a measurement of time-dependent CP-violating asymmetries in decays of neutral B mesons to the final states D(*-/+)pi(+/-), using approximately 82x10(6) BBmacr; events recorded by the BABAR experiment at the PEP-II e(+)e(-) storage ring. Events containing these decays are selected with a partial reconstruction technique, in which only the high-momentum pi(+/-) from the B decay and the low-momentum pi(-/+) from the D(*-/+) decay are used. We measure the amplitude of the asymmetry to be -0.063+/-0.024(stat)+/-0.014(syst) and compute bounds on |sin((2beta+gamma)|.

  9. Measurement of the CP Violating Phase $\\boldsymbol{\\sin(2\\beta_{s})}$ using $\\boldsymbol{B^{0}_{s}\\rightarrow J/\\psi\\phi}$ Decays at CDF

    SciTech Connect

    Pueschel, Elisa

    2010-05-01

    A B0 s meson can oscillate into its anti-particle, the $\\bar{B}$0 s meson, before decaying. CP violation in this system is made possible by the presence of amplitudes from both mixed and unmixed B0 s meson decays. The CP violating phase βs appears in the interference between the decay amplitudes. The quantity sin(2βs) is expected to be small in the standard model. Thus, measuring a large value for sin(2βs) would be an unequivocal sign of new physics participation in the B0 s mixing loop diagram. In this thesis, we present a latest measurement of sin(2βs), using 5.2 fb-1 of data collected at CDF from p$\\bar{p}$ collisions at a center of mass energy of √s=1.96 TeV. A time-dependent angular analysis, with the production flavor of the B0 s meson identified with flavor tagging methods, is used to extract sin(2βs) from ~6500 B0 s→ J/ψφ decays. Other parameters of interest, such as the B0 s lifetime and the decay width difference between the heavy and light B0 s mass eigenstates are determined to high precision. Also, the effect of potential contributions to the final state from B0 s → J/ψf0 and B0 s→ J/ψK+K- decays is considered for the first time. We present 68% and 95% confidence regions in the βs plane. The probability that the observed central value is a fluctuation of the data from the standard model expected value of βs is calculated to be 44%. The observed confidence region shows better agreement with the standard model prediction than previous measurements.

  10. The social construction of homosexuals in the nineteenth century: the shift from the sin to the influence of medicine on criminalizing sodomy in Germany.

    PubMed

    Hutter, J

    1993-01-01

    Psychiatry and forensic medicine developed a medical model of deviance locating the source of homosexual behavior within the individual and postulating a physiological condition that is assumed to cause the deviant behavior. The shift in deviance designation from sexually sinful behavior to sexually unhealthy individuals affected social control and sexual criminal law in Germany during the second half of the 19th century. This research project analyzes the process of legislation and the application of sexual law in the German Reich during the period between 1860 and 1920.

  11. Measurement of sin2θefflept using e+e- pairs from γ*/Z bosons produced in p p ¯ collisions at a center-of-momentum energy of 1.96 TeV

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bland, K. R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H. S.; Burkett, K.; Busetto, G.; Bussey, P.; Butti, P.; Buzatu, A.; Calamba, A.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cerri, A.; Cerrito, L.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Chokheli, D.; Clark, A.; Clarke, C.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; d'Ascenzo, N.; Datta, M.; de Barbaro, P.; Demortier, L.; Deninno, M.; D'Errico, M.; Devoto, F.; Di Canto, A.; Di Ruzza, B.; Dittmann, J. R.; Donati, S.; D'Onofrio, M.; Dorigo, M.; Driutti, A.; Ebina, K.; Edgar, R.; Erbacher, R.; Errede, S.; Esham, B.; Farrington, S.; Fernández Ramos, J. P.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Frisch, H.; Funakoshi, Y.; Galloni, C.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C. M.; Giokaris, N.; Giromini, P.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González López, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gramellini, E.; Grosso-Pilcher, C.; Guimaraes da Costa, J.; Hahn, S. R.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, M.; Harr, R. F.; Harrington-Taber, T.; Hatakeyama, K.; Hays, C.; Heinrich, J.; Herndon, M.; Hocker, A.; Hong, Z.; Hopkins, W.; Hou, S.; Hughes, R. E.; Husemann, U.; Hussein, M.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jindariani, S.; Jones, M.; Joo, K. K.; Jun, S. Y.; Junk, T. R.; Kambeitz, M.; Kamon, T.; Karchin, P. E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. H.; Kim, S. B.; Kim, Y. J.; Kim, Y. K.; Kimura, N.; Kirby, M.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kurata, M.; Laasanen, A. T.; Lammel, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lee, H. S.; Lee, J. S.; Leo, S.; Leone, S.; Lewis, J. D.; Limosani, A.; Lipeles, E.; Lister, A.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lucà, A.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Marchese, L.; Margaroli, F.; Marino, P.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Nigmanov, T.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagliarone, C.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parker, W.; Pauletta, G.; Paulini, M.; Paus, C.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Pranko, A.; Prokoshin, F.; Ptohos, F.; Punzi, G.; Redondo Fernández, I.; Renton, P.; Rescigno, M.; Rimondi, F.; Ristori, L.; Robson, A.; Rodriguez, T.; Rolli, S.; Ronzani, M.; Roser, R.; Rosner, J. L.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Sakumoto, W. K.; Sakurai, Y.; Santi, L.; Sato, K.; Saveliev, V.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, E. E.; Schwarz, T.; Scodellaro, L.; Scuri, F.; Seidel, S.; Seiya, Y.; Semenov, A.; Sforza, F.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shochet, M.; Shreyber-Tecker, I.; Simonenko, A.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Song, H.; Sorin, V.; St. Denis, R.; Stancari, M.; Stentz, D.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thomson, E.; Thukral, V.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Ukegawa, F.; Uozumi, S.; Vázquez, F.; Velev, G.; Vellidis, C.; Vernieri, C.; Vidal, M.; Vilar, R.; Vizán, J.; Vogel, M.; Volpi, G.; Wagner, P.; Wallny, R.; Wang, S. M.; Waters, D.; Wester, W. C.; Whiteson, D.; Wicklund, A. B.; Wilbur, S.; Williams, H. H.; Wilson, J. S.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, H.; Wright, T.; Wu, X.; Wu, Z.; Yamamoto, K.; Yamato, D.; Yang, T.; Yang, U. K.; Yang, Y. C.; Yao, W.-M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Zanetti, A. M.; Zeng, Y.; Zhou, C.; Zucchelli, S.; CDF Collaboration

    2016-06-01

    At the Fermilab Tevatron proton-antiproton (p p ¯) collider, Drell-Yan lepton pairs are produced in the process p p ¯→e+e-+X through an intermediate γ*/Z boson. The forward-backward asymmetry in the polar-angle distribution of the e- as a function of the e+e--pair mass is used to obtain sin2θefflept, the effective leptonic determination of the electroweak-mixing parameter sin2θW. The measurement sample, recorded by the Collider Detector at Fermilab (CDF), corresponds to 9.4 fb-1 of integrated luminosity from p p ¯ collisions at a center-of-momentum energy of 1.96 TeV, and is the full CDF Run II data set. The value of sin2θefflept is found to be 0.23248 ±0.00053 . The combination with the previous CDF measurement based on μ+μ- pairs yields sin2θefflept=0.23221±0.00046 . This result, when interpreted within the specified context of the standard model assuming sin2θW=1 - MW2/MZ2 and that the W - and Z -boson masses are on-shell, yields sin2θW=0.22400 ±0.00045 , or equivalently a W -boson mass of 80.328 ±0.024 GeV /c2 .

  12. Indirect measurement of sin2θW (or MW) using μ+μ- pairs from γ*/Z bosons produced in pp ¯ collisions at a center-of-momentum energy of 1.96 TeV

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bland, K. R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H. S.; Burkett, K.; Busetto, G.; Bussey, P.; Butti, P.; Buzatu, A.; Calamba, A.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Chokheli, D.; Clark, A.; Clarke, C.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; d'Ascenzo, N.; Datta, M.; de Barbaro, P.; Demortier, L.; Deninno, M.; D'Errico, M.; Devoto, F.; Di Canto, A.; Di Ruzza, B.; Dittmann, J. R.; Donati, S.; D'Onofrio, M.; Dorigo, M.; Driutti, A.; Ebina, K.; Edgar, R.; Elagin, A.; Erbacher, R.; Errede, S.; Esham, B.; Farrington, S.; Fernández Ramos, J. P.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Frisch, H.; Funakoshi, Y.; Galloni, C.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C. M.; Giokaris, N.; Giromini, P.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González López, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gramellini, E.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Guimaraes da Costa, J.; Hahn, S. R.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, M.; Harr, R. F.; Harrington-Taber, T.; Hatakeyama, K.; Hays, C.; Heinrich, J.; Herndon, M.; Hocker, A.; Hong, Z.; Hopkins, W.; Hou, S.; Hughes, R. E.; Husemann, U.; Hussein, M.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jindariani, S.; Jones, M.; Joo, K. K.; Jun, S. Y.; Junk, T. R.; Kambeitz, M.; Kamon, T.; Karchin, P. E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. H.; Kim, S. B.; Kim, Y. J.; Kim, Y. K.; Kimura, N.; Kirby, M.; Knoepfel, K.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kurata, M.; Laasanen, A. T.; Lammel, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lee, H. S.; Lee, J. S.; Leo, S.; Leone, S.; Lewis, J. D.; Limosani, A.; Lipeles, E.; Lister, A.; Liu, H.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lucà, A.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Marchese, L.; Margaroli, F.; Marino, P.; Martínez, M.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Nigmanov, T.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagliarone, C.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parker, W.; Pauletta, G.; Paulini, M.; Paus, C.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Pranko, A.; Prokoshin, F.; Ptohos, F.; Punzi, G.; Ranjan, N.; Redondo Fernández, I.; Renton, P.; Rescigno, M.; Rimondi, F.; Ristori, L.; Robson, A.; Rodriguez, T.; Rolli, S.; Ronzani, M.; Roser, R.; Rosner, J. L.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Sakumoto, W. K.; Sakurai, Y.; Santi, L.; Sato, K.; Saveliev, V.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, E. E.; Schwarz, T.; Scodellaro, L.; Scuri, F.; Seidel, S.; Seiya, Y.; Semenov, A.; Sforza, F.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shochet, M.; Shreyber-Tecker, I.; Simonenko, A.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Song, H.; Sorin, V.; St. Denis, R.; Stancari, M.; Stentz, D.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thomson, E.; Thukral, V.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Ukegawa, F.; Uozumi, S.; Vázquez, F.; Velev, G.; Vellidis, C.; Vernieri, C.; Vidal, M.; Vilar, R.; Vizán, J.; Vogel, M.; Volpi, G.; Wagner, P.; Wallny, R.; Wang, S. M.; Waters, D.; Wester, W. C., III; Whiteson, D.; Wicklund, A. B.; Wilbur, S.; Williams, H. H.; Wilson, J. S.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, H.; Wright, T.; Wu, X.; Wu, Z.; Yamamoto, K.; Yamato, D.; Yang, T.; Yang, U. K.; Yang, Y. C.; Yao, W.-M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Zanetti, A. M.; Zeng, Y.; Zhou, C.; Zucchelli, S.; CDF Collaboration

    2014-04-01

    Drell-Yan lepton pairs are produced in the process pp ¯→μ+μ-+X through an intermediate γ*/Zboson. The forward-backward asymmetry in the polar-angle distribution of the μ- as a function of the invariant mass of the μ+μ- pair is used to obtain the effective leptonic determination sin2θefflept of the electroweak-mixing parameter sin2θW, from which the value of sin2θW is derived assuming the standard model. The measurement sample, recorded by the Collider Detector at Fermilab (CDF), corresponds to 9.2 fb-1 of integrated luminosity from pp ¯ collisions at a center-of-momentum energy of 1.96 TeV, and is the full CDF Run II data set. The value of sin2θefflept is found to be 0.2315±0.0010, where statistical and systematic uncertainties are combined in quadrature. When interpreted within the context of the standard model using the on-shell renormalization scheme, where sin2θW=1-MW2/MZ2, the measurement yields sin2θW=0.2233±0.0009, or equivalently a W-boson mass of 80.365±0.047 GeV/c2. The value of the W-boson mass is in agreement with previous determinations in electron-positron collisions and at the Tevatron collider.

  13. In vacuo growth studies of Ru thin films on Si, SiN, and SiO2 by high-sensitivity low energy ion scattering

    NASA Astrophysics Data System (ADS)

    Coloma Ribera, R.; van de Kruijs, R. W. E.; Sturm, J. M.; Yakshin, A. E.; Bijkerk, F.

    2016-08-01

    In vacuo high-sensitivity low energy ion scattering (HS-LEIS) has been used to investigate the initial growth stages of DC sputtered Ru on top of Si, SiN, and SiO2. The high surface sensitivity of this technique allowed an accurate determination of surface coverages and thicknesses required for closing the Ru layer on all three substrates. The Ru layer closes (100% Ru surface signal) at about 2.0, 3.2, and 4.7 nm on top of SiO2, SiN, and Si, respectively. In-depth Ru concentration profiles can be reconstructed from the Ru surface coverages when considering an error function like model. The large intermixing (4.7 nm) for the Ru-on-Si system is compared to the reverse system (Si-on-Ru), where only 0.9 nm intermixing occurs. The difference is predominantly explained by the strong Si surface segregation that is observed for Ru-on-Si. This surface segregation effect is also observed for Ru-on-SiN but is absent for Ru-on-SiO2. For this last system, in vacuo HS-LEIS analysis revealed surface oxygen directly after deposition, which suggests an oxygen surface segregation effect for Ru-on-SiO2. In vacuo XPS measurements confirmed this hypothesis based on the reaction of Ru with oxygen from the SiO2, followed by oxygen surface segregation.

  14. The Yeast Hrs1 Gene Is Involved in Positive and Negative Regulation of Transcription and Shows Genetic Characteristics Similar to Sin4 and Gal11

    PubMed Central

    Piruat, J. I.; Chavez, S.; Aguilera, A.

    1997-01-01

    We provide genetic evidence that HRS1/PGD1, a yeast gene previously identified as a suppressor of the hyper-recombination phenotype of hpr1, has positive and negative roles in transcriptional regulation. We have analyzed three differently regulated promoters, GAL1, PHO5 and HSP26, by β-galactosidase assays of lacZ-fused promoters and by Northern analysis of the endogenous genes. Transcription of these promoters was derepressed in hrs1δ mutants under conditions in which it is normally repressed in wild type. Under induced conditions it was either strongly reduced or significantly enhanced depending on the promoter system analyzed. Constitutive transcription was not affected, as determined in ADH1 and TEF2. In addition, Hrs1p was required for mating-factor expression, telomere-linked DNA silencing and DNA supercoiling of plasmids. Furthermore, hrs1δ suppressed Ty-insertion mutations and conferred a Gal(-) phenotype. Many of these phenotypes also result from mutations in GAL11, SIN4 or RGR1, which encode proteins of the RNA polII mediator. We also show that gal11δ and sin4δ partially suppress the hyper-rec phenotype of hpr1 mutants, although to a lesser extent than hrs1δ. Our results provide new evidence for the connection between hpr1δ-induced deletions and transcription. We discuss the possibility that Hrs1p might be a component of the RNA polII transcription machinery. PMID:9409823

  15. High-efficiency and wideband interlayer grating couplers in multilayer Si/SiO2/SiN platform for 3D integration of optical functionalities.

    PubMed

    Sodagar, Majid; Pourabolghasem, Reza; Eftekhar, Ali A; Adibi, Ali

    2014-07-14

    We have designed interlayer grating couplers with single/double metallic reflectors for Si/SiO(2)/SiN multilayer material platform. Out-of-plane diffractive grating couplers separated by 1.6 μm thick buffer SiO(2) layer are vertically stacked against each other in Si and SiN layers. Geometrical optimization using genetic algorithm coupled with electromagnetic simulations using two-dimensional (2D) finite element method (FEM) results in coupler designs with high peak coupling efficiency of up to 89% for double- mirror and 64% for single-mirror structures at telecom wavelength. Also, 3-dB bandwidths of 40 nm and 50 nm are theoretically predicted for the two designs, respectively. We have fabricated the grating coupler structure with single mirror. Measured values for insertion loss and 3-dB bandwidth in the fabricated single-mirror coupler confirms the theoretical results. This opens up the possibility of low-loss 3D dense integration of optical functionalities in hybrid material platforms.

  16. Precise Measurement of the CP Violation Parameter sin1 in B⁰→(cc̄)K⁰ Decays

    SciTech Connect

    Adachi, I.; Aihara, H.; Asner, D. M.; Aulchenko, V.; Aushev, T.; Aziz, T.; Bakich, A. M.; Bay, A.; Bhardwaj, V.; Bhuyan, B.; Bischofberger, M.; Bondar, A.; Bozek, A.; Bračko, M.; Browder, T. E.; Chen, P.; Cheon, B. G.; Chilikin, K.; Chistov, R.; Cho, K.; Choi, S.-K.; Choi, Y.; Dalseno, J.; Danilov, M.; Doležal, Z.; Drásal, Z.; Eidelman, S.; Epifanov, D.; Fast, J. E.; Gaur, V.; Gabyshev, N.; Garmash, A.; Goh, Y. M.; Golob, B.; Haba, J.; Hara, K.; Hara, T.; Hayasaka, K.; Hayashii, H.; Higuchi, T.; Horii, Y.; Hoshi, Y.; Hou, W.-S.; Hsiung, Y. B.; Hyun, H. J.; Iijima, T.; Ishikawa, A.; Itoh, R.; Iwabuchi, M.; Iwasaki, Y.; Iwashita, T.; Julius, T.; Kapusta, P.; Katayama, N.; Kawasaki, T.; Kichimi, H.; Kiesling, C.; Kim, H. J.; Kim, H. O.; Kim, J. B.; Kim, J. H.; Kim, K. T.; Kim, Y. J.; Kinoshita, K.; Ko, B. R.; Koblitz, S.; Kodyš, P.; Korpar, S.; Križan, P.; Krokovny, P.; Kuhr, T.; Kumar, R.; Kumita, T.; Kuzmin, A.; Kwon, Y.-J.; Lange, J. S.; Lee, S.-H.; Li, J.; Li, Y.; Liu, C.; Liu, Y.; Liu, Z. Q.; Liventsev, D.; Louvot, R.; Matvienko, D.; McOnie, S.; Miyabayashi, K.; Miyata, H.; Miyazaki, Y.; Mizuk, R.; Mohanty, G. B.; Mori, T.; Muramatsu, N.; Nakano, E.; Nakao, M.; Nakazawa, H.; Neubauer, S.; Nishida, S.; Nishimura, K.; Nitoh, O.; Ogawa, S.; Ohshima, T.; Okuno, S.; Olsen, S. L.; Onuki, Y.; Ozaki, H.; Pakhlov, P.; Pakhlova, G.; Park, H. K.; Park, K. S.; Pedlar, T. K.; Pestotnik, R.; Petrič, M.; Piilonen, L. E.; Poluektov, A.; Röhrken, M.; Rozanska, M.; Sahoo, H.; Sakai, K.; Sakai, Y.; Sanuki, T.; Sato, Y.; Schneider, O.; Schwanda, C.; Schwartz, A. J.; Senyo, K.; Shebalin, V.; Shen, C. P.; Shibata, T.-A.; Shiu, J.-G.; Shwartz, B.; Sibidanov, A.; Simon, F.; Singh, J. B.; Smerkol, P.; Sohn, Y.-S.; Sokolov, A.; Solovieva, E.; Stanič, S.; Starič, M.; Sumihama, M.; Sumisawa, K.; Sumiyoshi, T.; Tanaka, S.; Tatishvili, G.; Teramoto, Y.; Tikhomirov, I.; Trabelsi, K.; Tsuboyama, T.; Uchida, M.; Uehara, S.; Uglov, T.; Unno, Y.; Uno, S.; Ushiroda, Y.; Vahsen, S. E.; Varner, G.; Varvell, K. E.; Vinokurova, A.; Vorobyev, V.; Wang, C. H.; Wang, M.-Z.; Wang, P.; Watanabe, M.; Watanabe, Y.; Williams, K. M.; Won, E.; Yabsley, B. D.; Yamamoto, H.; Yamashita, Y.; Yamauchi, M.; Yusa, Y.; Zhang, Z. P.; Zhilich, V.; Zupanc, A.; Zyukova, O.

    2012-04-23

    We present a precise measurement of the CP violation parameter sin1 and the direct CP violation parameter Af using the final data sample of 772×10⁶ BB¯¯¯ pairs collected at the Υ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider. One neutral B meson is reconstructed in a J/ψK0S, ψ(2S)K0S, χc1K0S, or J/ψK0L CP eigenstate and its flavor is identified from the decay products of the accompanying B meson. From the distribution of proper-time intervals between the two B decays, we obtain the following CP violation parameters: sin1=0.667±0.023(stat)±0.012(syst) and Af=0.006±0.016(stat)±0.012(syst).

  17. Measurement of the CP-Violation Parameter sin2Φ₁ with a New Tagging Method at the Υ(5S) Resonance

    SciTech Connect

    Sato, Y.; Yamamoto, H.; Aihara, H.; Asner, D. M.; Aulchenko, V.; Aushev, T.; Aziz, T.; Bakich, A. M.; Bhardwaj, V.; Bhuyan, B.; Bischofberger, M.; Bondar, A.; Bozek, A.; Bračko, M.; Browder, T. E.; Chang, P.; Chen, P.; Cheon, B. G.; Chilikin, K.; Chistov, R.; Cho, I.-S.; Cho, K.; Choi, S.-K.; Choi, Y.; Dalseno, J.; Doležal, Z.; Drásal, Z.; Eidelman, S.; Epifanov, D.; Fast, J. E.; Gaur, V.; Gabyshev, N.; Goh, Y. M.; Golob, B.; Haba, J.; Hara, T.; Hayasaka, K.; Hayashii, H.; Horii, Y.; Hoshi, Y.; Hou, W.-S.; Hyun, H. J.; Ishikawa, A.; Itoh, R.; Iwabuchi, M.; Iwasaki, Y.; Iwashita, T.; Julius, T.; Kapusta, P.; Kawasaki, T.; Kichimi, H.; Kiesling, C.; Kim, H. J.; Kim, H. O.; Kim, J. B.; Kim, J. H.; Kim, K. T.; Kim, M. J.; Kim, S. K.; Kim, Y. J.; Kinoshita, K.; Ko, B. R.; Kobayashi, N.; Kodyš, P.; Korpar, S.; Križan, P.; Krokovny, P.; Kuhr, T.; Kumar, R.; Kumita, T.; Kuzmin, A.; Kwon, Y.-J.; Lange, J. S.; Lee, S.-H.; Li, J.; Li, Y.; Liu, C.; Liu, Z. Q.; Louvot, R.; McOnie, S.; Miyabayashi, K.; Miyata, H.; Mizuk, R.; Mohanty, G. B.; Moll, A.; Muramatsu, N.; Nakano, E.; Nakao, M.; Nakazawa, H.; Natkaniec, Z.; Nishida, S.; Nishimura, K.; Nitoh, O.; Ogawa, S.; Ohshima, T.; Okuno, S.; Olsen, S. L.; Onuki, Y.; Ostrowicz, W.; Pakhlov, P.; Pakhlova, G.; Park, C. W.; Park, H.; Park, H. K.; Pedlar, T. K.; Petrič, M.; Piilonen, L. E.; Poluektov, A.; Röhrken, M.; Ryu, S.; Sahoo, H.; Sakai, Y.; Sanuki, T.; Schneider, O.; Schwanda, C.; Schwartz, A. J.; Seidl, R.; Senyo, K.; Seon, O.; Sevior, M. E.; Shapkin, M.; Shen, C. P.; Shibata, T.-A.; Shiu, J.-G.; Shwartz, B.; Sibidanov, A.; Simon, F.; Smerkol, P.; Sohn, Y.-S.; Sokolov, A.; Solovieva, E.; Stanič, S.; Starič, M.; Stypula, J.; Sumihama, M.; Sumiyoshi, T.; Tanaka, S.; Tatishvili, G.; Teramoto, Y.; Trabelsi, K.; Uchida, M.; Uglov, T.; Unno, Y.; Uno, S.; Urquijo, P.; Varner, G.; Varvell, K. E.; Wang, C. H.; Wang, M.-Z.; Wang, P.; Wang, X. L.; Watanabe, M.; Watanabe, Y.; Wicht, J.; Won, E.; Yabsley, B. D.; Yamashita, Y.; Yusa, Y.; Zhang, Z. P.; Zhilich, V.; Zhulanov, V.; Zupanc, A.

    2012-04-23

    We report a measurement of the CP-violation parameter sin2Φ₁ at the Υ(5S) resonance using a new tagging method, called “B-π tagging.” In Υ(5S) decays containing a neutral B meson, a charged B, and a charged pion, the neutral B is reconstructed in the J/ψK0SCP-eigenstate decay channel. The initial flavor of the neutral B meson at the moment of the Υ(5S) decay is opposite to that of the charged B and may thus be inferred from the charge of the pion without reconstructing the charged B. From the asymmetry between B-π⁺ and Bπ⁻ tagged J/ψK0S yields, we determine sin2Φ₁=0.57±0.58(stat)±0.06(syst). The results are based on 121 fb⁻¹ of data recorded by the Belle detector at the KEKB e⁺e⁻ collider.

  18. Measurement of the CP-Violation Parameter sin2Φ₁ with a New Tagging Method at the Υ(5S) Resonance

    DOE PAGESBeta

    Sato, Y.; Yamamoto, H.; Aihara, H.; Asner, D. M.; Aulchenko, V.; Aushev, T.; Aziz, T.; Bakich, A. M.; Bhardwaj, V.; Bhuyan, B.; et al

    2012-04-23

    We report a measurement of the CP-violation parameter sin2Φ₁ at the Υ(5S) resonance using a new tagging method, called “B-π tagging.” In Υ(5S) decays containing a neutral B meson, a charged B, and a charged pion, the neutral B is reconstructed in the J/ψK0SCP-eigenstate decay channel. The initial flavor of the neutral B meson at the moment of the Υ(5S) decay is opposite to that of the charged B and may thus be inferred from the charge of the pion without reconstructing the charged B. From the asymmetry between B-π⁺ and Bπ⁻ tagged J/ψK0S yields, we determine sin2Φ₁=0.57±0.58(stat)±0.06(syst). The resultsmore » are based on 121 fb⁻¹ of data recorded by the Belle detector at the KEKB e⁺e⁻ collider.« less

  19. SIN Retroviral Vectors Expressing COL7A1 Under Human Promoters for Ex Vivo Gene Therapy of Recessive Dystrophic Epidermolysis Bullosa

    PubMed Central

    Titeux, Matthias; Pendaries, Valérie; Zanta-Boussif, Maria A; Décha, Audrey; Pironon, Nathalie; Tonasso, Laure; Mejia, José E; Brice, Agnes; Danos, Olivier; Hovnanian, Alain

    2010-01-01

    Recessive dystrophic epidermolysis bullosa (RDEB) is caused by loss-of-function mutations in COL7A1 encoding type VII collagen which forms key structures (anchoring fibrils) for dermal–epidermal adherence. Patients suffer since birth from skin blistering, and develop severe local and systemic complications resulting in poor prognosis. We lack a specific treatment for RDEB, but ex vivo gene transfer to epidermal stem cells shows a therapeutic potential. To minimize the risk of oncogenic events, we have developed new minimal self-inactivating (SIN) retroviral vectors in which the COL7A1 complementary DNA (cDNA) is under the control of the human elongation factor 1α (EF1α) or COL7A1 promoters. We show efficient ex vivo genetic correction of primary RDEB keratinocytes and fibroblasts without antibiotic selection, and use either of these genetically corrected cells to generate human skin equivalents (SEs) which were grafted onto immunodeficient mice. We achieved long-term expression of recombinant type VII collagen with restored dermal–epidermal adherence and anchoring fibril formation, demonstrating in vivo functional correction. In few cases, rearranged proviruses were detected, which were probably generated during the retrotranscription process. Despite this observation which should be taken under consideration for clinical application, this preclinical study paves the way for a therapy based on grafting the most severely affected skin areas of patients with fully autologous SEs genetically corrected using a SIN COL7A1 retroviral vector. PMID:20485266

  20. X-ray evaluation of electronic and chemical properties and film structures in SiN passivation layer on crystalline Si solar cells

    NASA Astrophysics Data System (ADS)

    Yamashita, Yoshihiro; Ikeno, Norihiro; Tachibana, Tomihisa; Ohshita, Yoshio; Ogura, Atsushi

    2015-08-01

    We investigated the electronic chemical properties and film structures in SiN passivation layers on crystalline Si by X-ray photoelectron spectroscopy (XPS) and X-ray reflectometry (XRR). From XPS analyses, a N-rich component (N-Si-N) and oxygen mixing were observed at the interface. The longest lifetime was obtained after post deposition annealing at 600 °C, where the N-rich layer was the thinnest with small peak height. Therefore, longer lifetime could be obtained as the N concentration at the interface decreased. The film consisted of three SiN layers and one SiO2 layer, as confirmed by XRR profile fitting. From the density profiles, a longer lifetime was obtained when the density gradient in the oxygen mixing layer was small. Results of XPS and XRR suggested that N at the interface significantly affected the lifetime. We believe it is important to understand the electronic chemical properties at the passivation interface to realize high-efficiency Si solar cells.

  1. SIN feature observed in intrinsic Josephson junction characteristics for overdoped Bi2Sr2CaCu2O8+δ

    NASA Astrophysics Data System (ADS)

    Suzuki, M.; Takemura, R.; Ohmaki, M.; Anagawa, K.

    2008-02-01

    We have fabricated mesa structures made of 5 to 10 intrinsic Josephson junctions (IJJs) from overdoped and slightly overdoped Bi2Sr2CaCu2O8+δ(BSCCO) crystals and observed in their tunneling spectra a characteristics structure or a broad peak within the superconducting gap. We propose that this structure results from the inclusion of nonsuperconducting regions in the superconducting layer of IJJs. The cause of the structure is presumed to be the tunneling current through a superconductor/insulator/normal-metal (SIN) junction and the voltage drop due to the current flow in the normal regions after the tunneling through the SIN junctions. The broad peak located at a higher than Δ/eposition reflects the current path through the normal region. All these features imply that the superconducting state is inhomogeneous. The experimental results are compared with numerical calculations based on a simple model to obtain a good agreement. From the comparison, it is concluded that the nonsuperconducting and superconducting regions coexist in overdoped BSCCO on a ~ 50 nm scale.

  2. Biogeographic and ecological regulation of disease: Prevalence of Sin Nombre virus in island mice is related to island area, precipitation, and predator richness

    USGS Publications Warehouse

    Orrock, John L.; Allan, Brian F.; Drost, Charles A.

    2011-01-01

    The relative roles of top-down and bottom-up forces in affecting disease prevalence in wild hosts is important for understanding disease dynamics and human disease risk. We found that the prevalence of Sin Nombre virus (SNV), the agent of a severe disease in humans (hantavirus pulmonary syndrome), in island deer mice from the eight California Channel Islands was greater with increased precipitation (a measure of productivity), greater island area, and fewer species of rodent predators. In finding a strong signal of the ecological forces affecting SNV prevalence, our work highlights the need for future work to understand the relative importance of average rodent density, population fluctuations, behavior, and specialist predators as they affect SNV prevalence. In addition to illustrating the importance of both bottom-up and top-down limitation of disease prevalence, our results suggest that predator richness may have important bearing on the risk of exposure to animal-borne diseases that affect humans.

  3. Pincharse sin infectarse: estrategias para prevenir la infección por el VIH y el VHC entre usuarios de drogas inyectables

    PubMed Central

    MATEU-GELABERT, P.; FRIEDMAN, S.; SANDOVAL, M.

    2011-01-01

    Resumen Objetivo Desde principios de los noventa, en la ciudad de Nueva York se han implementado con éxito programas para reducir la incidencia del virus de la inmunodeficiencia humana (VIH) y, en menor medida, del virus de la hepatitis C (VHC). A pesar de ello, aproximadamente el 70% de los usuario de drogas inyectables (UDI) están infectados por el VHC. Queremos investigar cómo el 30% restante se las ha arreglado para no infectarse. El Staying safe (nombre original del estudio) explora los comportamientos y mecanismos que ayudan a evitar la infección por el VHC y el VIH a largo plazo. Material y métodos Hemos utilizado el concepto de «desviación positiva» aplicado en otros campos de salud pública. Estudiamos las estrategias, prácticas y tácticas de prevención de aquellos UDI que, viviendo en contextos de alta prevalencia, se mantienen sin infectar por VIH y el VHC, a pesar de haberse inyectado heroína durante años. Los resultados preliminares presentados en este artículo incluyen el análisis de las entrevistas realizadas a 25 UDI (17 doble negativos, 3 doble positivos y 5 con infección por el VHC y sin infección por el VIH). Se usaron entrevistas semiestructuradas que exploraban con detalle la historia de vida de los sujetos, incluyendo su consumo de drogas, redes sociales, contacto con instituciones, relaciones sexuales y estrategias de protección y vigilancia. Resultados La intencionalidad es importante para no infectarse, especialmente durante períodos de involución (períodos donde hay un deterioro económico y/o social que llevan al que se inyecta a situaciones de mayor riesgo). Presentamos tres dimensiones independientes de intencionalidad que conllevan comportamientos que pueden ayudar a prevenir la infección: a) evitar «el mono» (síntomas de abstención) asegurando el acceso a la droga; b) «llevarlo bien» para no convertirse en un junkie y así evitar la «muerte social» y la falta de acceso a los recursos, y c) seguir sin

  4. Transverse momentum dependent distribution function h1T [perpendicular] and the single spin asymmetry A(UT)sin(3 phi-\\phi_S)

    SciTech Connect

    Avakian, Harutyun; V. Efremov, A.; Schweitzer, Peter; Yuan, Feng

    2008-12-01

    The leading twist transverse momentum dependent parton distribution function h_1T^perp, which is sometimes called ``pretzelosity,' is studied. We review the theoretical properties of this function, and present bag model predictions. We observe an interesting relation valid in a large class of relativistic models: The difference between helicity and transversity distributions, which is often said to be a 'measure of relativistic effects' in nucleon, is nothing but the pretzelosity distribution. Pretzelosity is chirally odd and can be accessed in combination with the Collins effect in semi-inclusive deep inelastic scattering, where it gives rise to an azimuthal single spin asymmetry proportional to sin(3phi-phi_S). We discuss the preliminary deuteron target data from COMPASS, on that observable and make predictions for future experiments on various targets at JLab, COMPASS and HERMES.

  5. Effect of SiN x diffusion barrier thickness on the structural properties and photocatalytic activity of TiO2 films obtained by sol-gel dip coating and reactive magnetron sputtering.

    PubMed

    Ghazzal, Mohamed Nawfal; Aubry, Eric; Chaoui, Nouari; Robert, Didier

    2015-01-01

    We investigate the effect of the thickness of the silicon nitride (SiN x ) diffusion barrier on the structural and photocatalytic efficiency of TiO2 films obtained with different processes. We show that the structural and photocatalytic efficiency of TiO2 films produced using soft chemistry (sol-gel) and physical methods (reactive sputtering) are affected differentially by the intercalating SiN x diffusion barrier. Increasing the thickness of the SiN x diffusion barrier induced a gradual decrease of the crystallite size of TiO2 films obtained by the sol-gel process. However, TiO2 obtained using the reactive sputtering method showed no dependence on the thickness of the SiN x barrier diffusion. The SiN x barrier diffusion showed a beneficial effect on the photocatalytic efficiency of TiO2 films regardless of the synthesis method used. The proposed mechanism leading to the improvement in the photocatalytic efficiency of the TiO2 films obtained by each process was discussed.

  6. Extraction of $\\sin^2\\theta^{\\rm lept}_{\\rm eff}$ and indirect measurement of $m_w$ from the 9 fb$^{-1}$ full run ii sample of $\\mu^+\\mu^-$ events at cdf

    SciTech Connect

    Bodek, A.

    2014-09-19

    We report on the extraction of $\\sin^2\\theta^{\\rm lept}_{\\rm eff}$ and indirect measurement of the mass of the W boson from the forward-backward asymmetry of $\\mu^+\\mu^-$ events in the $Z$ boson mass region. The data sample collected by the CDF detector corresponds to the full 9 fb$^{-1}$ run II sample. We measure $\\sin^2 \\theta^{\\rm lept}_{\\rm eff} = 0.2315 \\pm 0.0010$,$ \\sin^2 \\theta_W = 0.2233 \\pm 0.0009$ and $M_W ({\\rm indirect}) = 80.365 \\pm 0.047 \\;{\\rm GeV}/c^2$, where each uncertainty includes both statistical and systematic contributions.

  7. The reduction of EPSC amplitude in CA1 pyramidal neurons by the peroxynitrite donor SIN-1 requires Ca2+ influx via postsynaptic non-L-type voltage gated calcium channels.

    PubMed

    Zhaowei, Liu; Yongling, Xie; Jiajia, Yang; Zhuo, Yang

    2014-02-01

    The peroxynitrite free radical (ONOO(-)) modulation of miniature excitatory postsynaptic currents (mEPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) was investigated in rat CA1 pyramidal neurons using the whole-cell patch clamp technique. SIN-1(3-morpholino-sydnonimine), which can lead the simultaneous generation of superoxide anion and nitric oxide, and then form the highly reactive species ONOO(-), induced dose-dependent inhibition in amplitudes of both mEPSCs and sEPSCs. The SIN-1 action on mEPSC amplitude was completely blocked by U0126, a selective MEK inhibitor, suggesting that MEK contributed to the action of ONOO(-) on mEPSCs. The effect of SIN-1 was completely occluded either in the presence of the calcium chelator EGTA or the non-selective calcium channel antagonist Cd(2+). Furthermore, the application of nifedipine (20 μM), the L-type calcium channel blocker, had no effect on the ONOO(-)-induced decrease in mEPSC amplitude, excluding a role for L-type voltage-gated Ca(2+) channels in this process. SIN-1 inhibited the frequency of sEPSCs but had no effect on mEPSC frequency, which suggested a presynaptic action potential-dependent the action of ONOO(-) at CA1 pyramidal neuron synapses. The best-known glutamatergic input to CA1 pyramidal neurons is via Schaffer collaterals from CA3 area. However, no changes were observed in slices treated with SIN-1 on the spontaneous firing rates of CA3 pyramidal neurons. These findings suggested that SIN-1 inhibited glutamatergic synaptic transmission of CA1 pyramidal neurons by a postsynaptic non-L-type voltage gated calcium channel-dependent mechanism.

  8. Geochemical distribution of harmful elements in top soils of an Italian National Interest Area (S.I.N.): the Domizio-Flegreo Littoral and Agro Aversano case study

    NASA Astrophysics Data System (ADS)

    Bove, M.; Grezzi, G.; Albanese, S.; de Vivo, B.; Lima, A.

    2009-04-01

    The Domizio-Flegreo Littoral and Agro Aversano area has been classified by the Italian Ministry of Environment (Italian Ministero dell'Ambiente e della Tutela del Territorio e del Mare) as a S.I.N. (Sito di Interesse Nazionale, L. 426/98 - Decreto 10 Gennaio 2000 - G.U. 29/5/01). In this category have been included all those contaminated lands that, both for their extension and their historical and present land use, are considered to be particularly harmful for human health. In Italy have been selected a total of 54 S.I.N.; among all of these, the Domizio-Flegreo Littoral and Agro Aversano S.I.N. is one of the widest (1564 Km2). The study area is located in north-western Campania region, from the Avella Mountain to the coastline, and from the Campi Flegrei area to the northern boundaries between Campania and Latium Regions. It includes a total of 77 towns from both Naples and Caserta provinces. The Domizio-Flegreo Littoral and Agro Aversano S.I.N. is characterized by a strongly urbanization in its internal portions, and by intensive agricultural activities in its northern and coastal portions. During past years this wide area has been the set of an unknown number of illegal activities controlled by the organized crime, including toxic waste disposal of unknown sources from different Regions of Italy, unauthorized building, intensive uncontrolled agricultural practices and so on. Part of these environmental crimes have been and are under investigations by Italian Authorities. For a geochemical characterization of this contaminated land, between May 2006 and January 2008, a total of 292 (179 in the Litorale Domizio-Flegreo and 113 in the Agro Aversano) top soils (5-15 cm depth) have been collected, with a sampling density of about 1 sample/5 Km2. The <100 mesh soil fraction has been analyzed with ICP-MS to determine the concentration of the 39 elements: Ag, Al, As, Au, B, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, K, La, Mg, Mn, Mo, Na, Ni, P, Pb, S, Sb, Sc, Se, Sn

  9. The interplay of plant and animal disease in a changing landscape: the role of sudden aspen decline in moderating Sin Nombre virus prevalence in natural deer mouse populations.

    PubMed

    Lehmer, Erin M; Korb, Julie; Bombaci, Sara; McLean, Nellie; Ghachu, Joni; Hart, Lacey; Kelly, Ashley; Jara-Molinar, Edlin; O'Brien, Colleen; Wright, Kimberly

    2012-06-01

    We examined how climate-mediated forest dieback regulates zoonotic disease prevalence using the relationship between sudden aspen decline (SAD) and Sin Nombre virus (SNV) as a model system. We compared understory plant community structure, small mammal community composition, and SNV prevalence on 12 study sites within aspen forests experiencing levels of SAD ranging from <10.0% crown fade to >95.0% crown fade. Our results show that sites with the highest levels of SAD had reduced canopy cover, stand density, and basal area, and these differences were reflected by reductions in understory vegetation cover. Conversely, sites with the highest levels of SAD had greater understory standing biomass, suggesting that vegetation on these sites was highly clustered. Changes in forest and understory vegetation structure likely resulted in shifts in small mammal community composition across the SAD gradient, as we found reduced species diversity and higher densities of deer mice, the primary host for SNV, on sites with the highest levels of SAD. Sites with the highest levels of SAD also had significantly greater SNV prevalence compared to sites with lower levels of SAD, which is likely a result of their abundance of deer mice. Collectively, results of our research provide strong evidence to show SAD has considerable impacts on vegetation community structure, small mammal density and biodiversity and the prevalence of SNV. PMID:22526751

  10. SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II.

    PubMed

    Song, W; Treich, I; Qian, N; Kuchin, S; Carlson, M

    1996-01-01

    The RNA polymerase II of Saccharomyces cerevisiae exists in holoenzyme forms containing a complex, known as the mediator, associated with the carboxyl-terminal domain. The mediator includes several SRB proteins and is required for transcriptional activation. Previous work showed that a cyclin-dependent kinase-cyclin pair encoded by SSN3 and SSN8, two members of the SSN suppressor family, are identical to two SRB proteins in the mediator. Here we have identified the remaining SSN genes by cloning and genetic analysis. SSN2 and SSN5 are identical to SRB9 and SRB8, respectively, which encode additional components of the mediator. Genetic evidence implicates the SSN genes in transcriptional repression. Thus, these identities provide genetic insight into mediator and carboxyl-terminal domain function, strongly suggesting a role in mediating transcriptional repression as well as activation. We also show that SSN4 and SSN7 are the same as SIN4 and ROX3, respectively, raising the possibility that these genes also encode mediator proteins.

  11. A new system for parallel drug screening against multiple-resistant HIV mutants based on lentiviral self-inactivating (SIN) vectors and multi-colour analyses

    PubMed Central

    2013-01-01

    Background Despite progress in the development of combined antiretroviral therapies (cART), HIV infection remains a significant challenge for human health. Current problems of cART include multi-drug-resistant virus variants, long-term toxicity and enormous treatment costs. Therefore, the identification of novel effective drugs is urgently needed. Methods We developed a straightforward screening approach for simultaneously evaluating the sensitivity of multiple HIV gag-pol mutants to antiviral drugs in one assay. Our technique is based on multi-colour lentiviral self-inactivating (SIN) LeGO vector technology. Results We demonstrated the successful use of this approach for screening compounds against up to four HIV gag-pol variants (wild-type and three mutants) simultaneously. Importantly, the technique was adapted to Biosafety Level 1 conditions by utilising ecotropic pseudotypes. This allowed upscaling to a large-scale screening protocol exploited by pharmaceutical companies in a successful proof-of-concept experiment. Conclusions The technology developed here facilitates fast screening for anti-HIV activity of individual agents from large compound libraries. Although drugs targeting gag-pol variants were used here, our approach permits screening compounds that target several different, key cellular and viral functions of the HIV life-cycle. The modular principle of the method also allows the easy exchange of various mutations in HIV sequences. In conclusion, the methodology presented here provides a valuable new approach for the identification of novel anti-HIV drugs. PMID:23286882

  12. Knockdown of Selenocysteine-Specific Elongation Factor in Amblyomma maculatum Alters the Pathogen Burden of Rickettsia parkeri with Epigenetic Control by the Sin3 Histone Deacetylase Corepressor Complex

    PubMed Central

    Adamson, Steven W.; Browning, Rebecca E.; Budachetri, Khemraj; Ribeiro, José M. C.; Karim, Shahid

    2013-01-01

    Selenocysteine is the 21st naturally-occurring amino acid. Selenoproteins have diverse functions and many remain uncharacterized, but they are typically associated with antioxidant activity. The incorporation of selenocysteine into the nascent polypeptide chain recodes the TGA stop codon and this process depends upon a number of essential factors including the selenocysteine elongation factor (SEF). The transcriptional expression of SEF did not change significantly in tick midguts throughout the blood meal, but decreased in salivary glands to 20% at the end of the fast feeding phase. Since selenoprotein translation requires this specialized elongation factor, we targeted this gene for knockdown by RNAi to gain a global view of the role selenoproteins play in tick physiology. We found no significant differences in tick engorgement and embryogenesis but detected no antioxidant capacity in tick saliva. The transcriptional profile of selenoproteins in R. parkeri-infected Amblyomma maculatum revealed declined activity of selenoprotein M and catalase and increased activity of selenoprotein O, selenoprotein S, and selenoprotein T. Furthermore, the pathogen burden was significantly altered in SEF-knockdowns. We then determined the global impact of SEF-knockdown by RNA-seq, and mapped huge shifts in secretory gene expression that could be the result of downregulation of the Sin3 histone deacetylase corepressor complex. PMID:24282621

  13. The Hlma Project in the Light of the First Kamland Results Measurement of sin2 (2θ13) with a New Short Baseline Reactor Neutrino Experiment

    NASA Astrophysics Data System (ADS)

    Lasserre, Thierry; Schönert, Stefan; Oberauer, Lothar

    2004-04-01

    The year 2002 was very fruitful for low energy neutrino physics. Prior to the results of SNO and KamLAND, a few solutions were perfectly allowed by the combination of all the results of solar and terrestrial neutrino experiments. In that context, the HLMA project was originally proposed to improve the KamLAND determination of the solar mixing parameters if Δ msol2 >=slant 2 10{ - 4} eV2 . In this article we analyse the impact of this project in the light of the first KamLAND results. Altought not new, the possibility to constraint the mixing angle between the third mass field and the electron field with a short baseline reactor neutrino experiment is explored in this article. We show that an experiment with a near detector close to a nuclear reactor and a far detector at about 2 kilometers distance could provide a limit of sin2 (2θ13) < 0.02 (90%C.L.), competitive and complementary with the next generation of accelerator long baseline experiments. Nevertheless, the total systematic error uncertainty has to be reduced by a factor three with respect to the CHOOZ experiment to achieve this goal.

  14. In-situ investigation of stress conditions during expansion of bare metal stents and PLLA-coated stents using the XRD sin(2)ψ-technique.

    PubMed

    Kowalski, Wolfgang; Dammer, Markus; Bakczewitz, Frank; Schmitz, Klaus-Peter; Grabow, Niels; Kessler, Olaf

    2015-09-01

    Drug eluting stents (DES) consist of platform, coating and drug. The platform often is a balloon-expandable bare metal stent made of the CoCr alloy L-605 or stainless steel 316 L. The function of the coating, typically a permanent polymer, is to hold and release the drug, which should improve therapeutic outcome. Before implantation, DES are compressed (crimped) to allow implantation in the human body. During implantation, DES are expanded by balloon inflation. Crimping, as well as expansion, causes high stresses and high strains locally in the DES struts, as well as in the polymer coating. These stresses and strains are important design criteria of DES. Usually, they are calculated numerically by finite element analysis (FEA), but experimental results for validation are hardly available. In this work, the X-ray diffraction (XRD) sin(2)ψ-technique is applied to in-situ determination of stress conditions of bare metal L-605 stents, and Poly-(L-lactide) (PLLA) coated stents. This provides a realistic characterization of the near-surface stress state and a validation option of the numerical FEA. XRD-results from terminal stent struts of the bare metal stent show an increasing compressive load stress in tangential direction with increasing stent expansion. These findings correlate with numerical FEA results. The PLLA-coating also bears increasing compressive load stress during expansion.

  15. Comparisons of SiN Passivation Film Deposited by PE-CVD and T-CVD Method for AlGaN/GaN HEMTs on SiC Substrate

    NASA Astrophysics Data System (ADS)

    Okita, Hideyuki; Marui, Toshiharu; Hoshi, Shinichi; Itoh, Masanori; Toda, Fumihiko; Morino, Yoshiaki; Tamai, Isao; Sano, Yoshiaki; Seki, Shohei

    Current collapse phenomenon is a well known obstacle in the AlGaN/GaN HEMTs. In order to improve the surface stability of HEMTs, we have investigated the SiN passivation film deposited by T-CVD, and we found that it improves both gate leakage current and current collapse phenomenon [1]. Moreover, we compared the T-CVD and PE-CVD passivation films, on high electric field DC and RF characteristics. We found that T-CVD SiN passivation film improves BVds-off by 30% because of the reduction of gate leakage current. It also improved ηd in the output power characteristics by load-pull measurement, which indicates the decrease of the current collapse phenomenon. Also we fabricated a multi-fingered 50W-class AlGaN/GaN HEMT with T-CVD SiN passivation film and achieved 61.2% of high drain efficiency at frequency of 2.14GHz, which was 3.6 points higher than that with PE-CVD SiN passivation film.

  16. Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.

    PubMed

    Zika, Eleni; Greer, Susanna F; Zhu, Xin-Sheng; Ting, Jenny P-Y

    2003-05-01

    The class II transactivator (CIITA) is a master transcriptional regulator of major histocompatibility complex class II (MHC-II) promoters. CIITA does not bind DNA, but it interacts with the transcription factors RFX5, NF-Y, and CREB and associated chromatin-modifying enzymes to form an enhanceosome. This report examines the effects of histone deacetylases 1 and 2 (HDAC1/HDAC2) on MHC-II gene induction by gamma interferon (IFN-gamma) and CIITA. The results show that an inhibitor of HDACs, trichostatin A, enhances IFN-gamma-induced MHC-II expression, while HDAC1/HDAC2 inhibits IFN-gamma- and CIITA-induced MHC-II gene expression. mSin3A, a corepressor of HDAC1/HDAC2, is important for this inhibition, while NcoR, a corepressor of HDAC3, is not. The effect of this inhibition is directed at CIITA, since HDAC1/HDAC2 reduces transactivation by a GAL4-CIITA fusion protein. CIITA binds to overexpressed and endogenous HDAC1, suggesting that HDAC and CIITA may affect each other by direct or indirect association. Inhibition of HDAC activity dramatically increases the association of NF-YB and RFX5 with CIITA, the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter. These results suggest a model where HDAC1/HDAC2 affect the function of CIITA through a disruption of MHC-II enhanceosome and relevant coactivator-transcription factor association and provide evidence that CIITA may act as a molecular switch to modulate MHC-II transcription by coordinating the functions of both histone acetylases and HDACs.

  17. Tunneling conductance of SIN junctions with different gap symmetries and non-magnetic impurities by direct solution of real-axis Eliashberg equations

    NASA Astrophysics Data System (ADS)

    Ummarino, G. A.; Gonnelli, R. S.; Daghero, D.

    2002-09-01

    We theoretically investigate the effect of various symmetries of the superconducting order parameter Δ( ω) on the normalized tunneling conductance of SIN junctions (with no spatial variation of the order parameter in the S electrode) by directly solving the real-axis Eliashberg equations (EEs) for a half-filled infinite band, with the simplifying assumption μ*=0. We analyze six different symmetries of the order parameter: s, d, s+id, s+d, extended s and anisotropic s, by assuming that the spectral function α 2F(Ω) contains an isotropic part α 2F(Ω) is and an anisotropic one, α 2F(Ω) an, such that α 2F(Ω) an=gα 2F(Ω) is, where g is a constant. We compare the resulting conductance curves at T=2 K to those obtained by analytical continuation of the imaginary-axis solution of the EEs, and we show that the agreement is not equally good for all symmetries. Then, we discuss the effect of non-magnetic impurities on the theoretical tunneling conductance curves at T=4 K for all the symmetries considered. Finally, as an example, we apply our calculations to the case of optimally-doped high- Tc superconductors. Surprisingly, although the possibility of explaining the very complex phenomenology of HTSC is probably beyond the limits of the Eliashberg theory, the comparison of the theoretical curves calculated at T=4 K with the experimental ones obtained in various optimally-doped copper-oxides gives fairly good results.

  18. Nebular excitation in z ∼ 2 star-forming galaxies from the SINS and LUCI surveys: The influence of shocks and active galactic nuclei

    SciTech Connect

    Newman, Sarah F.; Genzel, Reinhard; Buschkamp, Peter; Förster Schreiber, Natascha M.; Kurk, Jaron; Rosario, David; Davies, Ric; Eisenhauer, Frank; Lutz, Dieter; Sternberg, Amiel; Gnat, Orly; Mancini, Chiara; Renzini, Alvio; Lilly, Simon J.; Carollo, C. Marcella; Burkert, Andreas; Cresci, Giovanni; Genel, Shy; Shapiro Griffin, Kristen; Hicks, Erin K. S.; and others

    2014-01-20

    Based on high-resolution, spatially resolved data of 10 z ∼ 2 star-forming galaxies from the SINS/zC-SINF survey and LUCI data for 12 additional galaxies, we probe the excitation properties of high-z galaxies and the impact of active galactic nuclei (AGNs), shocks, and photoionization. We explore how these spatially resolved line ratios can inform our interpretation of integrated emission line ratios obtained at high redshift. Many of our galaxies fall in the 'composite' region of the z ∼ 0 [N II]/Hα versus [O III]/Hβ diagnostic (BPT) diagram, between star-forming galaxies and those with AGNs. Based on our resolved measurements, we find that some of these galaxies likely host an AGN, while others appear to be affected by the presence of shocks possibly caused by an outflow or from an enhanced ionization parameter as compared with H II regions in normal, local star-forming galaxies. We find that the Mass-Excitation (MEx) diagnostic, which separates purely star-forming and AGN hosting local galaxies in the [O III]/Hβ versus stellar mass plane, does not properly separate z ∼ 2 galaxies classified according to the BPT diagram. However, if we shift the galaxies based on the offset between the local and z ∼ 2 mass-metallicity relation (i.e., to the mass they would have at z ∼ 0 with the same metallicity), we find better agreement between the MEx and BPT diagnostics. Finally, we find that metallicity calibrations based on [N II]/Hα are more biased by shocks and AGNs at high-z than the [O III]/Hβ/[N II]/Hα calibration.

  19. Allelic Variation and Differential Expression of the mSIN3A Histone Deacetylase Complex Gene Arid4b Promote Mammary Tumor Growth and Metastasis

    PubMed Central

    Winter, Scott F.; Lukes, Luanne; Walker, Renard C.; Welch, Danny R.; Hunter, Kent W.

    2012-01-01

    Accumulating evidence suggests that breast cancer metastatic progression is modified by germline polymorphism, although specific modifier genes have remained largely undefined. In the current study, we employ the MMTV-PyMT transgenic mouse model and the AKXD panel of recombinant inbred mice to identify AT–rich interactive domain 4B (Arid4b; NM_194262) as a breast cancer progression modifier gene. Ectopic expression of Arid4b promoted primary tumor growth in vivo as well as increased migration and invasion in vitro, and the phenotype was associated with polymorphisms identified between the AKR/J and DBA/2J alleles as predicted by our genetic analyses. Stable shRNA–mediated knockdown of Arid4b caused a significant reduction in pulmonary metastases, validating a role for Arid4b as a metastasis modifier gene. ARID4B physically interacts with the breast cancer metastasis suppressor BRMS1, and we detected differential binding of the Arid4b alleles to histone deacetylase complex members mSIN3A and mSDS3, suggesting that the mechanism of Arid4b action likely involves interactions with chromatin modifying complexes. Downregulation of the conserved Tpx2 gene network, which is comprised of many factors regulating cell cycle and mitotic spindle biology, was observed concomitant with loss of metastatic efficiency in Arid4b knockdown cells. Consistent with our genetic analysis and in vivo experiments in our mouse model system, ARID4B expression was also an independent predictor of distant metastasis-free survival in breast cancer patients with ER+ tumors. These studies support a causative role of ARID4B in metastatic progression of breast cancer. PMID:22693453

  20. Epstein-Barr virus nuclear antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A.

    PubMed

    Jiang, Sizun; Willox, Bradford; Zhou, Hufeng; Holthaus, Amy M; Wang, Anqi; Shi, Tommy T; Maruo, Seiji; Kharchenko, Peter V; Johannsen, Eric C; Kieff, Elliott; Zhao, Bo

    2014-01-01

    Epstein-Barr virus nuclear antigen 3C (EBNA3C) repression of CDKN2A p14(ARF) and p16(INK4A) is essential for immortal human B-lymphoblastoid cell line (LCL) growth. EBNA3C ChIP-sequencing identified >13,000 EBNA3C sites in LCL DNA. Most EBNA3C sites were associated with active transcription; 64% were strong H3K4me1- and H3K27ac-marked enhancers and 16% were active promoters marked by H3K4me3 and H3K9ac. Using ENCODE LCL transcription factor ChIP-sequencing data, EBNA3C sites coincided (±250 bp) with RUNX3 (64%), BATF (55%), ATF2 (51%), IRF4 (41%), MEF2A (35%), PAX5 (34%), SPI1 (29%), BCL11a (28%), SP1 (26%), TCF12 (23%), NF-κB (23%), POU2F2 (23%), and RBPJ (16%). EBNA3C sites separated into five distinct clusters: (i) Sin3A, (ii) EBNA2/RBPJ, (iii) SPI1, and (iv) strong or (v) weak BATF/IRF4. EBNA3C signals were positively affected by RUNX3, BATF/IRF4 (AICE) and SPI1/IRF4 (EICE) cooccupancy. Gene set enrichment analyses correlated EBNA3C/Sin3A promoter sites with transcription down-regulation (P < 1.6 × 10(-4)). EBNA3C signals were strongest at BATF/IRF4 and SPI1/IRF4 composite sites. EBNA3C bound strongly to the p14(ARF) promoter through SPI1/IRF4/BATF/RUNX3, establishing RBPJ-, Sin3A-, and REST-mediated repression. EBNA3C immune precipitated with Sin3A and conditional EBNA3C inactivation significantly decreased Sin3A binding at the p14(ARF) promoter (P < 0.05). These data support a model in which EBNA3C binds strongly to BATF/IRF4/SPI1/RUNX3 sites to enhance transcription and recruits RBPJ/Sin3A- and REST/NRSF-repressive complexes to repress p14(ARF) and p16(INK4A) expression. PMID:24344258

  1. SINS/zC-SINF Survey of z ˜ 2 Galaxy Kinematics: Rest-frame Morphology, Structure, and Colors from Near-infrared Hubble Space Telescope Imaging

    NASA Astrophysics Data System (ADS)

    Tacchella, S.; Lang, P.; Carollo, C. M.; Förster Schreiber, N. M.; Renzini, A.; Shapley, A. E.; Wuyts, S.; Cresci, G.; Genzel, R.; Lilly, S. J.; Mancini, C.; Newman, S. F.; Tacconi, L. J.; Zamorani, G.; Davies, R. I.; Kurk, J.; Pozzetti, L.

    2015-04-01

    We present the analysis of Hubble Space Telescope (HST) J- and H-band imaging for 29 galaxies on the star-forming main sequence at z ˜ 2, which have adaptive optics Very Large Telescope SINFONI integral field spectroscopy from our SINS/zC-SINF program. The SINFONI Hα data resolve the ongoing star formation and the ionized gas kinematics on scales of 1-2 kpc; the near-IR images trace the galaxies’ rest-frame optical morphologies and distributions of stellar mass in old stellar populations at a similar resolution. The global light profiles of most galaxies show disk-like properties well described by a single Sérsic profile with n˜ 1, with only ˜ 15% requiring a high n\\gt 3 Sérsic index, all more massive than {{10}10} {{M}⊙ }. In bulge+disk fits, about 40% of galaxies have a measurable bulge component in the light profiles, with ˜ 15% showing a substantial bulge-to-total ratio (B/T) B/T≳ 0.3. This is a lower limit to the frequency of z ˜ 2 massive galaxies with a developed bulge component in stellar mass because it could be hidden by dust and/or outshined by a thick actively star-forming disk component. The galaxies’ rest-optical half-light radii range between 1 and 7 kpc, with a median of 2.1 kpc, and lie slightly above the size-mass relation at these epochs reported in the literature. This is attributed to differences in sample selection and definitions of size and/or mass measurements. The {{(u-g)}rest} color gradient and scatter within individual z ˜ 2 massive galaxies with ≳ {{10}11} {{M}⊙ } are as high as in z = 0 low-mass, late-type galaxies and are consistent with the high star formation rates of massive z ˜ 2 galaxies being sustained at large galactocentric distances. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute.

  2. Nebular Excitation in z ~ 2 Star-forming Galaxies from the SINS and LUCI Surveys: The Influence of Shocks and Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Newman, Sarah F.; Buschkamp, Peter; Genzel, Reinhard; Förster Schreiber, Natascha M.; Kurk, Jaron; Sternberg, Amiel; Gnat, Orly; Rosario, David; Mancini, Chiara; Lilly, Simon J.; Renzini, Alvio; Burkert, Andreas; Carollo, C. Marcella; Cresci, Giovanni; Davies, Ric; Eisenhauer, Frank; Genel, Shy; Shapiro Griffin, Kristen; Hicks, Erin K. S.; Lutz, Dieter; Naab, Thorsten; Peng, Yingjie; Tacconi, Linda J.; Wuyts, Stijn; Zamorani, Gianni; Vergani, Daniela; Weiner, Benjamin J.

    2014-01-01

    Based on high-resolution, spatially resolved data of 10 z ~ 2 star-forming galaxies from the SINS/zC-SINF survey and LUCI data for 12 additional galaxies, we probe the excitation properties of high-z galaxies and the impact of active galactic nuclei (AGNs), shocks, and photoionization. We explore how these spatially resolved line ratios can inform our interpretation of integrated emission line ratios obtained at high redshift. Many of our galaxies fall in the "composite" region of the z ~ 0 [N II]/Hα versus [O III]/Hβ diagnostic (BPT) diagram, between star-forming galaxies and those with AGNs. Based on our resolved measurements, we find that some of these galaxies likely host an AGN, while others appear to be affected by the presence of shocks possibly caused by an outflow or from an enhanced ionization parameter as compared with H II regions in normal, local star-forming galaxies. We find that the Mass-Excitation (MEx) diagnostic, which separates purely star-forming and AGN hosting local galaxies in the [O III]/Hβ versus stellar mass plane, does not properly separate z ~ 2 galaxies classified according to the BPT diagram. However, if we shift the galaxies based on the offset between the local and z ~ 2 mass-metallicity relation (i.e., to the mass they would have at z ~ 0 with the same metallicity), we find better agreement between the MEx and BPT diagnostics. Finally, we find that metallicity calibrations based on [N II]/Hα are more biased by shocks and AGNs at high-z than the [O III]/Hβ/[N II]/Hα calibration. Based on observations at the Very Large Telescope (VLT) of the European Southern Observatory (ESO), Paranal, Chile (ESO program IDs 073.B-9018, 076.A-0527, 079.A-0341, 080.A-0330, 080.A-0339, 080.A-0635, 083.A-0781,084.A-0853, 087.A-0081, 091.A.-0126) and at the Large Binocular Telescope (LBT) on Mt. Graham in Arizona.

  3. Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart

    PubMed Central

    2013-01-01

    Background Exercise causes physiological cardiac hypertrophy and benefits the diabetic heart. Mammalian switch-independent 3A (mSin3A) and histone deacetylases (HDACs) 1 and 2 regulate hypertrophic genes through associations with the DNA binding proteins repressor element-1 silencing transcription factor (REST) and O-linked β-N-acetylglucosamine transferase (OGT). O-linked β-N-acetylglucosamine (O-GlcNAc) is a glucose derivative that is chronically elevated in diabetic hearts, and a previous study showed that exercise reduces cardiac O-GlcNAc. We hypothesized that O-GlcNAc and OGT would physically associate with mSin3A/HDAC1/2 in the heart, and that this interaction would be altered by diabetes and exercise. Methods 8-week-old type 2 diabetic db/db (db) and non-diabetic C57 mice were randomized to treadmill exercise or sedentary groups for 1 or 4 weeks. Results O-GlcNAc was significantly higher in db hearts and increased with exercise. Db hearts showed lower levels of mSin3A, HDAC1, and HDAC2 protein, but higher levels of HDAC2 mRNA and HDAC1/2 deacetylase activity. Elevated HDAC activity was associated with significantly blunted expression of α-actin and brain natriuretic peptide in db hearts. In sedentary db hearts, co-immunoprecipitation assays showed that mSin3A and OGT were less associated with HDAC1 and HDAC2, respectively, compared to sedentary C57 controls; however, exercise removed these differences. Conclusions These data indicate that diabetes and exercise oppositely affect interactions between pro-hypertrophic transcription factors, and suggest that an increase in total cardiac O-GlcNAc is a mechanism by which exercise benefits type 2 diabetic hearts. PMID:23835259

  4. The dependency of different stress-level SiN capping films and the optimization of D-SMT process for the device performance booster in Ge n-FinFETs

    SciTech Connect

    Liao, M.-H. Chen, P.-G.

    2015-08-17

    The capping stressed SiN film is one of the most important process steps for the dislocation stress memorization technique (D-SMT), which has been used widely in the current industry, for the electron mobility booster in the n-type transistor beyond the 32/28 nm technology node. In this work, we found that the different stress-level SiN capping films influence the crystal re-growth velocities along different directions including [100] and [110] directions in Ge a lot. It can be further used to optimize the dislocation angle in the transistor during the D-SMT process and then results in the largest channel stress distribution to boost the device performance in the Ge n-FinFETs. Based on the theoretical calculation and experimental demonstration, it shows that the Ge three dimensional (3D) n-FinFETs device performance is improved ∼55% with the usage of +3 GPa tensile stressed SiN capping film. The channel stress and dislocation angle is ∼2.5 GPa and 30°, measured by the atomic force microscope-Raman technique and transmission electron microscopy, respectively.

  5. Multiple embryos in the Lepidocyclina pustulosa group as possible indicators of palaeoenvironmental conditions: The case of the Late Eocene Toluviejo Formation (Sinú Domain, Caribbean, Colombia

    NASA Astrophysics Data System (ADS)

    Baumgartner-Mora, Claudia; Baumgartner, Peter O.; Rincón Martínez, Daniel; Salazar Ortiz, Edward A.

    2016-04-01

    The Middle-Late Eocene Toluviejo Formation of the Sinú-San Jacinto folded belt (Caribbean, Colombia) contains 15-75 m thick, grey, massive limestone sequences that are interbedded with terrigenous nearshore to offshore mudstones to quartzose sandstones and conglomerates. The formation accumulated in a transitional continent-ocean setting, probably on oceanic crust. We studied over 80 polished thin sections under light microscopy and cathodoluminescence (CL) to analyse carbonate microfacies and Larger Benthic Foraminifera (LBF). The overall facies distribution is 3-fold: (1) Facies close to the shoreline are dominated by low diversity operculinid assemblages, rich in detrital elements. (2) Shallow offshore facies are characterized by round lepidocyclinids, associated with, and often encrusted by, corallinacean algae, Sporolithon and structureless microbial crusts. The matrix is rich in carbonate/detrital mud and sand-sized detritals. (3) Distal offshore facies on structural highs show abundance of flat, current-sorted lepidoclinids without a noticeable detrital component. Facies 1 and 2 are clearly under the influence of suspension- and dissolved-nutrient input, probably carried offshore by freshwater lids of river plumes. Facies (2) contains abundant specimens of the Lepidocyclina pustulosa group of which the macrospheric forms show complicated embryonic apparatuses, which suppose double or multiple embryos. Detailed observation under CL allows to count up to 6-8 embryos, often seen aligned in the equatorial plane. The embryonic apparatus occupies often more than half of the diameter of specimens. The tendency towards large, very flat embryonic apparatuses (diameter measured in axial cuts up to 2,5 mm for a thickness of 0.2-0.3 mm) is closely correlated with abundant coralgal and microbial encrustations, oxide-stained carbonate/detrital mud and probably some preserved organic matter. The presence of multiple embryos has been reported by several authors and has

  6. Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.

    PubMed

    Suryadinata, Randy; Sadowski, Martin; Steel, Rohan; Sarcevic, Boris

    2011-02-18

    Eukaryotic cell cycle progression is mediated by phosphorylation of protein substrates by cyclin-dependent kinases (CDKs). A critical substrate of CDKs is the product of the retinoblastoma tumor suppressor gene, pRb, which inhibits G(1)-S phase cell cycle progression by binding and repressing E2F transcription factors. CDK-mediated phosphorylation of pRb alleviates this inhibitory effect to promote G(1)-S phase cell cycle progression. pRb represses transcription by binding to the E2F transactivation domain and recruiting the mSin3·histone deacetylase (HDAC) transcriptional repressor complex via the retinoblastoma-binding protein 1 (RBP1). RBP1 binds to the pocket region of pRb via an LXCXE motif and to the SAP30 subunit of the mSin3·HDAC complex and, thus, acts as a bridging protein in this multisubunit complex. In the present study we identified RBP1 as a novel CDK substrate. RBP1 is phosphorylated by CDK2 on serines 864 and 1007, which are N- and C-terminal to the LXCXE motif, respectively. CDK2-mediated phosphorylation of RBP1 or pRb destabilizes their interaction in vitro, with concurrent phosphorylation of both proteins leading to their dissociation. Consistent with these findings, RBP1 phosphorylation is increased during progression from G(1) into S-phase, with a concurrent decrease in its association with pRb in MCF-7 breast cancer cells. These studies provide new mechanistic insights into CDK-mediated regulation of the pRb tumor suppressor during cell cycle progression, demonstrating that CDK-mediated phosphorylation of both RBP1 and pRb induces their dissociation to mediate release of the mSin3·HDAC transcriptional repressor complex from pRb to alleviate transcriptional repression of E2F.

  7. The role of isovalency in the reactions of the cyano (CN), boron monoxide (BO), silicon nitride (SiN), and ethynyl (C2H) radicals with unsaturated hydrocarbons acetylene (C2H2) and ethylene (C2H4).

    PubMed

    Parker, D S N; Mebel, A M; Kaiser, R I

    2014-04-21

    The classification of chemical reactions based on shared characteristics is at the heart of the chemical sciences, and is well exemplified by Langmuir's concept of isovalency, in which 'two molecular entities with the same number of valence electrons have similar chemistries'. Within this account we further investigate the ramifications of the isovalency of four radicals with the same X(2)Σ(+) electronic structure - cyano (CN), boron monoxide (BO), silicon nitride (SiN), and ethynyl (C2H), and their reactions with simple prototype hydrocarbons acetylene (C2H2) and ethylene (C2H4). The fact that these four reactants own the same X(2)Σ(+) electronic ground state should dictate the outcome of their reactions with prototypical hydrocarbons holding a carbon-carbon triple and double bond. However, we find that other factors come into play, namely, atomic radii, bonding orbital overlaps, and preferential location of the radical site. These doublet radical reactions with simple hydrocarbons play significant roles in extreme environments such as the interstellar medium and planetary atmospheres (CN, SiN and C2H), and combustion flames (C2H, BO). PMID:24418936

  8. Reflexiones Sobre Investigacion Educacional (Reflections on Educational Research).

    ERIC Educational Resources Information Center

    Valle, Victor M.

    Educational research can serve to improve education in both developed and developing countries. It can be oriented toward increasing knowledge about the educational reality, generating theories, or confirming immediate educational political decisions. Educational research should be an interdisciplinary undertaking; this variety helps to unify…

  9. Consentimiento informado: una praxis dialogica para la investigacion

    PubMed Central

    Mondragon-Barrios, Liliana

    2009-01-01

    El consentimiento informado es un proceso, en el que una persona acepta participar en una investigation, conociendo los riesgos, beneficios, consecuencias o problemas que se puedan presenter durante el desarrollo de la misma. El objetivo de este trabajo es reunir las caracteristicas del proceso de consentimiento informado (PCI) pare que su discernimiento y cumplimiento posibilite el ejercicio etc° dialogico, reflexivo y responsable del investigador. Se presentan los resultados de una extensa revision de les elementos del PCI, desde sus cornponentes hasta su fundamento etico y legal, incluyendo los mites y realidades que existen sobre el formato de consentimiento informado come recurso legal de protection. El consentimiento informado no es un formato establecido que los investigadores repliquen, se trata de que la praxis del PCI sea una tarea cotidiana dentro de la investigation con seres humanos, como comunicaciOn deliberative y critica, responsable y comprometida entre dos agentes morales, investigador-investigado. PMID:19507477

  10. Revista de Investigacion Educativa, 2000 (Journal of Educational Research, 2000).

    ERIC Educational Resources Information Center

    Revista de Investigacion Educativa, 2000

    2000-01-01

    Articles in this volume focus on the following: teacher evaluation and quality management in education; steps toward a comprehensive and systematic staff evaluation; opinions of university students on teaching methods at science faculties; design of a scale to assess the ability to jump for the use in elementary school physical education; effects…

  11. Revista de Investigacion Educativa, 1998 (Journal of Educational Research, 1998).

    ERIC Educational Resources Information Center

    Revista de Investigacion Educativa, 1998

    1998-01-01

    Articles in this volume focus on the following: specialized research; methodological challenges; establishment of a categorization system for sociometric analysis and its application in the multicultural classroom; a case study of factors to prevent school failure in children at risk; the KeyMatch-R scale (study of a curriculum-related diagnostic…

  12. Revista de Investigacion Educativa, 2001 (Journal of Educational Research, 2001).

    ERIC Educational Resources Information Center

    Revista de Investigacion Educativa, 2001

    2001-01-01

    Articles in this volume focus on the following: student counseling and other factors determining course choices of university students; a focus on unspecific diagnoses of students with learning disabilities; self-evaluations aimed at improving the quality of schools; relationship of academic goals and the use of different learning and study…

  13. Revista de Investigacion Educativa (Journal of Educational Research).

    ERIC Educational Resources Information Center

    Revista de Investigacion Educativa, 1997

    1997-01-01

    The two issues of this journal include the following articles (Titles are translated into English): "General Panorama of Research on Intercultural Education in Europe" (Margarita Bartolome Pina); "Incidence of Some Educational, Social, and Affective Factors in Alcohol Consumption by Teenagers" (Elvira Repetto Talavera, Ma. Peregrina Senra Varela);…

  14. Revista de Investigacion Educativa, 2002 (Journal of Educational Research, 2002).

    ERIC Educational Resources Information Center

    Revista de Investigacion Educativa, 2002

    2002-01-01

    This journal, which deals with topics in educational research, includes articles written in Spanish (translated here) such as the following: "Management of the Competence of Professional Action (CAP)]" (Benito Echeverria Samanes); "Concepts and Beliefs of Andalusian Secondary School Teachers on Mathematics Assessments" (Francisco Gil Cuadra, Luis…

  15. Revista de Investigacion Educativa, 1999 (Journal of Educational Research, 1999).

    ERIC Educational Resources Information Center

    Revista de Investigacion Educativa, 1999

    1999-01-01

    Articles in this volume, written in Spanish, focus on the following: intellectual style and academic performance; an explanatory integrated model of academic goals, learning strategies, and academic performance; a comparative situational study of drug addiction; early childhood depression and academic performance: a comparative study of patients…

  16. Measurement of the forward-backward charge asymmetry and extraction of sin2thetaWeff in pp-->Z/gamma* + X-->e+e- +X events produced at sqrt[s] = 1.96 TeV.

    PubMed

    Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguilo, E; Ahn, S H; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Anderson, S; Andrieu, B; Anzelc, M S; Aoki, M; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; Asman, B; Assis Jesus, A C S; Atramentov, O; Avila, C; Badaud, F; Baden, A; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Barfuss, A-F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benitez, J A; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Biscarat, C; Blazey, G; Blekman, F; Blessing, S; Bloch, D; Bloom, K; Boehnlein, A; Boline, D; Bolton, T A; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Buchanan, N J; Buchholz, D; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burke, S; Burnett, T H; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Carvalho, W; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K; Chan, K M; Chandra, A; Charles, F; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Crépé-Renaudin, S; Cutts, D; Cwiok, M; da Motta, H; Das, A; Davies, G; De, K; de Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; Degenhardt, J D; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Dominguez, A; Dong, H; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Gallas, E; Garcia, C; Garcia-Bellido, A; Gavrilov, V; Gay, P; Geist, W; Gelé, D; Gerber, C E; Gershtein, Y; Gillberg, D; Ginther, G; Gollub, N; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutierrez, G; Gutierrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Harder, K; Harel, A; Hauptman, J M; Hauser, R; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hoeth, H; Hohlfeld, M; Hong, S J; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jesik, R; Johns, K; Johnson, C; Johnson, M; Jonckheere, A; Jonsson, P; Juste, A; Kajfasz, E; Kalk, J M; Karmanov, D; Kasper, P A; Katsanos, I; Kau, D; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y M; Khatidze, D; Kim, T J; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Konrath, J-P; Kozelov, A V; Kraus, J; Krop, D; Kuhl, T; Kumar, A; Kupco, A; Kurca, T; Kuzmin, V A; Kvita, J; Lacroix, F; Lam, D; Lammers, S; Landsberg, G; Lebrun, P; Lee, W M; Leflat, A; Lellouch, J; Leveque, J; Li, J; Li, L; Li, Q Z; Lietti, S M; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajicek, M; Love, P; Lubatti, H J; Luna, R; Lyon, A L; Maciel, A K A; Mackin, D; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Mao, H S; Maravin, Y; Martin, B; McCarthy, R; Melnitchouk, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Millet, T; Mitrevski, J; Mommsen, R K; Mondal, N K; Moore, R W; Moulik, T; Muanza, G S; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Nogima, H; Novaes, S F; Nunnemann, T; O'Dell, V; O'Neil, D C; Obrant, G; Ochando, C; Onoprienko, D; Oshima, N; Osman, N; Osta, J; Otec, R; Otero y Garzón, G J; Owen, M; Padley, P; Pangilinan, M; Parashar, N; Park, S-J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Penning, B; Perfilov, M; Peters, K; Peters, Y; Pétroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M-E; Polozov, P; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Ranjan, K; Ratoff, P N; Renkel, P; Reucroft, S; Rich, P; Rieger, J; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rodrigues, R F; Rominsky, M; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Sanghi, B; Santoro, A; Savage, G; Sawyer, L; Scanlon, T; Schaile, D; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Siccardi, V; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Spurlock, B; Stark, J; Steele, J; Stolin, V; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, E; Strauss, M; Ströhmer, R; Strom, D; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Tamburello, P; Tanasijczuk, A; Taylor, W; Temple, J; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Toole, T; Torchiani, I; Trefzger, T; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; van den Berg, P J; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Vaupel, M; Verdier, P; Vertogradov, L S; Verzocchi, M; Villeneuve-Seguier, F; Vint, P; Vokac, P; Von Toerne, E; Voutilainen, M; Wagner, R; Wahl, H D; Wang, L; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Welty-Rieger, L; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Yacoob, S; Yamada, R; Yan, M; Yasuda, T; Yatsunenko, Y A; Yin, H; Yip, K; Yoo, H D; Youn, S W; Yu, J; Zeitnitz, C; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zivkovic, L; Zutshi, V; Zverev, E G

    2008-11-01

    We present a measurement of the forward-backward charge asymmetry (A FB) in pp-->Z/gamma* + X-->e+e(-) + X events at a center-of-mass energy of 1.96 TeV using 1.1 fb(-1) of data collected with the D0 detector at the Fermilab Tevatron collider. A FB is measured as a function of the invariant mass of the electron-positron pair, and found to be consistent with the standard model prediction. We use the A FB measurement to extract the effective weak mixing angle sin2thetaWeff = 0.2326+/-0.0018(stat)+/-0.0006(syst). PMID:19113259

  17. Transverse momentum dependent distribution function h{sub 1T}{sup perpendicular} and the single spin asymmetry A{sub UT}{sup sin(3{phi}-3S)}

    SciTech Connect

    Avakian, H.; Efremov, A. V.; Schweitzer, P.; Yuan, F.

    2008-12-01

    The leading twist transverse momentum dependent parton distribution function h{sub 1T}{sup perpendicular} is studied. We review the theoretical properties of this function, and compute it in the bag model. We find in the bag model an interesting relation, and observe it to hold also in other relativistic models: The difference between helicity and transversity distributions, often said to be a 'measure of relativistic effects' in the nucleon, is related to h{sub 1T}{sup perpendicular}. This function is chirally odd and can be accessed in combination with the Collins effect in semi-inclusive deep-inelastic scattering, where it gives rise to an azimuthal single spin asymmetry proportional to sin(3{phi}-{phi}{sub S}). We discuss preliminary COMPASS data on that observable and make predictions for future experiments on various targets at JLab, COMPASS, and HERMES.

  18. The SINS/zC-SINF survey of z ∼ 2 galaxy kinematics: Evidence for powerful active galactic nucleus-driven nuclear outflows in massive star-forming galaxies

    SciTech Connect

    Förster Schreiber, N. M.; Genzel, R.; Kurk, J. D.; Lutz, D.; Tacconi, L. J.; Wuyts, S.; Bandara, K.; Buschkamp, P.; Davies, R.; Eisenhauer, F.; Lang, P.; Newman, S. F.; Burkert, A.; Carollo, C. M.; Lilly, S. J.; Cresci, G.; Daddi, E.; Mainieri, V.; Mancini, C.; and others

    2014-05-20

    We report the detection of ubiquitous powerful nuclear outflows in massive (≥10{sup 11} M {sub ☉}) z ∼ 2 star-forming galaxies (SFGs), which are plausibly driven by an active galactic nucleus (AGN). The sample consists of the eight most massive SFGs from our SINS/zC-SINF survey of galaxy kinematics with the imaging spectrometer SINFONI, six of which have sensitive high-resolution adaptive optics-assisted observations. All of the objects are disks hosting a significant stellar bulge. The spectra in their central regions exhibit a broad component in Hα and forbidden [N II] and [S II] line emission, with typical velocity FWHM ∼ 1500 km s{sup –1}, [N II]/Hα ratio ≈ 0.6, and intrinsic extent of 2-3 kpc. These properties are consistent with warm ionized gas outflows associated with Type 2 AGN, the presence of which is confirmed via independent diagnostics in half the galaxies. The data imply a median ionized gas mass outflow rate of ∼60 M {sub ☉} yr{sup –1} and mass loading of ∼3. At larger radii, a weaker broad component is detected but with lower FWHM ∼485 km s{sup –1} and [N II]/Hα ≈ 0.35, characteristic for star formation-driven outflows as found in the lower-mass SINS/zC-SINF galaxies. The high inferred mass outflow rates and frequent occurrence suggest that the nuclear outflows efficiently expel gas out of the centers of the galaxies with high duty cycles and may thus contribute to the process of star formation quenching in massive galaxies. Larger samples at high masses will be crucial in confirming the importance and energetics of the nuclear outflow phenomenon and its connection to AGN activity and bulge growth.

  19. Fixed interface charges between AlGaN barrier and gate stack composed of in situ grown SiN and Al{sub 2}O{sub 3} in AlGaN/GaN high electron mobility transistors with normally off capability

    SciTech Connect

    Capriotti, M. Alexewicz, A.; Fleury, C.; Gavagnin, M.; Bethge, O.; Wanzenböck, H. D.; Bertagnolli, E.; Pogany, D.; Strasser, G.; Visalli, D.; Derluyn, J.

    2014-03-17

    Using a generalized extraction method, the fixed charge density N{sub int} at the interface between in situ deposited SiN and 5 nm thick AlGaN barrier is evaluated by measurements of threshold voltage V{sub th} of an AlGaN/GaN metal insulator semiconductor high electron mobility transistor as a function of SiN thickness. The thickness of the originally deposited 50 nm thick SiN layer is reduced by dry etching. The extracted N{sub int} is in the order of the AlGaN polarization charge density. The total removal of the in situ SiN cap leads to a complete depletion of the channel region resulting in V{sub th} = +1 V. Fabrication of a gate stack with Al{sub 2}O{sub 3} as a second cap layer, deposited on top of the in situ SiN, is not introducing additional fixed charges at the SiN/Al{sub 2}O{sub 3} interface.

  20. The Postmodern Sin of Intelligent Design Creationism

    ERIC Educational Resources Information Center

    Pennock, Robert T.

    2010-01-01

    That Intelligent Design Creationism rejects the methodological naturalism of modern science in favor of a premodern supernaturalist worldview is well documented and by now well known. An irony that has not been sufficiently appreciated, however, is the way that ID Creationists try to advance their premodern view by adopting (if only tactically) a…

  1. Scripture, Sin and Salvation: Theological Conservatism Reconsidered

    ERIC Educational Resources Information Center

    Hempel, Lynn M.; Bartkowski, John P.

    2008-01-01

    Using insights from ethnographic studies of conservative Protestant congregations, the authors propose and test a refined conceptual model of theological conservatism that accounts for three key components of a theologically conservative worldview: (1. epistemology, a belief in the Bible as the inspired word of God, (2. ontology, assumptions about…

  2. Radical Constructivism, and the Sin of Relativism

    ERIC Educational Resources Information Center

    Quale, Andreas

    2007-01-01

    The epistemology of "relativism" that is featured by the theory of radical constructivism is addressed. In particular, I examine several objections, all based on this epistemic position of relativism, that are often raised by critics of the theory: the charge of "reality denial" (which, it is often claimed, must lead ultimately to the…

  3. [Gestational surrogacy - sin, whim or necessity].

    PubMed

    Kosovski, I; Kovachev, E; Alexandrov, K; Kysyov, S; Markova, V

    2014-01-01

    The authors propose the gestational surrogacy to be permitted but only for medical indications and under exact requirements. The surrogate mother if married, her husband, too, sign with the commissioning adopting couple a legal agreement at the beginning of the procedures. PMID:25509646

  4. The five deadly sins of science publishing

    PubMed Central

    Tracz, Vitek

    2015-01-01

    Science cannot progress without scientists reporting their findings. And yet researchers have given control of this central pillar of the scientific process to science publishers, who are in the business of serving the interests of their journals; these are not always the same as the interests of science. This editorial describes the problems with the process of preparing and publishing research findings, and with judging their veracity and significance, and then explains how we at Faculty of 1000 are starting to tackle the ‘deadly sins’ of science publishing. PMID:26097694

  5. The Postmodern Sin of Intelligent Design Creationism

    NASA Astrophysics Data System (ADS)

    Pennock, Robert T.

    2010-06-01

    That Intelligent Design Creationism rejects the methodological naturalism of modern science in favor of a premodern supernaturalist worldview is well documented and by now well known. An irony that has not been sufficiently appreciated, however, is the way that ID Creationists try to advance their premodern view by adopting (if only tactically) a radical postmodern perspective. This paper will reveal the deep threads of postmodernism that run through the ID Creationist movement’s arguments, as evidenced in the writings and interviews of its key leaders. Seeing their arguments and activities from this perspective highlights the danger to science posed by both ID Creationism and radical postmodernism.

  6. Sin, Hope and Optimism in Children's Metaphors.

    ERIC Educational Resources Information Center

    Fraser, Deborah

    Metaphor-making is a universal human endeavor that manifests across cultures in various ways. Analyzing metaphors enables educators to gain a greater understanding of many social and cultural issues. Teaching children to write through metaphor based upon their emotional landscapes can reveal much of their inner worlds. Such texts can have a…

  7. Half Sinful Words: Disguised Grief in "Ulysses."

    ERIC Educational Resources Information Center

    Hobbs, Michael

    As a shrewd technician of the language, A. L. Tennyson rightly understood that words are not controllable; they do not always obey rules. As Tennyson said, words "half reveal and half conceal the soul within." In "Ulysses," the title character's speech to his fellow mariners--where he attempts to explain why he has decided to abandon domestic life…

  8. The Seven Deadly Sins of Online Microcomputing.

    ERIC Educational Resources Information Center

    King, Alan

    1989-01-01

    Offers suggestions for avoiding common errors in online microcomputer use. Areas discussed include learning the basics; hardware protection; backup options; hard disk organization; software selection; file security; and the use of dedicated communications lines. (CLB)

  9. Experimental and theoretical rationalization of the growth mechanism of silicon quantum dots in non-stoichiometric SiN x : role of chlorine in plasma enhanced chemical vapour deposition

    NASA Astrophysics Data System (ADS)

    Mon-Pérez, E.; Salazar, J.; Ramos, E.; Santoyo Salazar, J.; López Suárez, A.; Dutt, A.; Santana, G.; Marel Monroy, B.

    2016-11-01

    Silicon quantum dots (Si-QDs) embedded in an insulator matrix are important from a technological and application point of view. Thus, being able to synthesize them in situ during the matrix growth process is technologically advantageous. The use of SiH2Cl2 as the silicon precursor in the plasma enhanced chemical vapour deposition (PECVD) process allows us to obtain Si-QDs without post-thermal annealing. Foremost in this work, is a theoretical rationalization of the mechanism responsible for Si-QD generation in a film including an analysis of the energy released by the extraction of HCl and the insertion of silylene species into the terminal surface bonds. From the results obtained using density functional theory (DFT), we propose an explanation of the mechanism responsible for the formation of Si-QDs in non-stoichiometric SiN x starting from chlorinated precursors in a PECVD system. Micrograph images obtained through transmission electron microscopy confirmed the presence of Si-QDs, even in nitrogen-rich (N-rich) samples. The film stoichiometry was controlled by varying the growth parameters, in particular the NH3/SiH2Cl2 ratio and hydrogen dilution. Experimental and theoretical results together show that using a PECVD system, along with chlorinated precursors it is possible to obtain Si-QDs at a low substrate temperature without annealing treatment. The optical property studies carried out in the present work highlight the prospects of these thin films for down shifting and as an antireflection coating in silicon solar cells.

  10. Humans and Ferrets with Prior H1N1 Influenza Virus Infections Do Not Exhibit Evidence of Original Antigenic Sin after Infection or Vaccination with the 2009 Pandemic H1N1 Influenza Virus

    PubMed Central

    O'Donnell, Christopher D.; Wright, Amber; Vogel, Leatrice; Boonnak, Kobporn; Treanor, John J.

    2014-01-01

    The hypothesis of original antigenic sin (OAS) states that the imprint established by an individual's first influenza virus infection governs the antibody response thereafter. Subsequent influenza virus infection results in an antibody response against the original infecting virus and an impaired immune response against the newer influenza virus. The purpose of our study was to seek evidence of OAS after infection or vaccination with the 2009 pandemic H1N1 (2009 pH1N1) virus in ferrets and humans previously infected with H1N1 viruses with various antigenic distances from the 2009 pH1N1 virus, including viruses from 1935 through 1999. In ferrets, seasonal H1N1 priming did not diminish the antibody response to infection or vaccination with the 2009 pH1N1 virus, nor did it diminish the T-cell response, indicating the absence of OAS in seasonal H1N1 virus-primed ferrets. Analysis of paired samples of human serum taken before and after vaccination with a monovalent inactivated 2009 pH1N1 vaccine showed a significantly greater-fold rise in the titer of antibody against the 2009 pH1N1 virus than against H1N1 viruses that circulated during the childhood of each subject. Thus, prior experience with H1N1 viruses did not result in an impairment of the antibody response against the 2009 pH1N1 vaccine. Our data from ferrets and humans suggest that prior exposure to H1N1 viruses did not impair the immune response against the 2009 pH1N1 virus. PMID:24648486

  11. [Morphometric characteristics of the asterion and the posterolateral surface of the skull: its relationship with dural venous sinuses and its neurosurgical importance].

    PubMed

    Galindo-de León, Salvador; Hernández-Rodríguez, Alejandra Nohemí; Morales-Ávalos, Rodolfo; Theriot-Girón, María Del Carmen; Elizondo-Omaña, Rodrigo Enrique; Guzmán-López, Santos

    2013-01-01

    antecedentes: el conocimiento de la ubicación y características morfométricas del seno venoso lateral (transverso y sigmoides), así como de su relación con este y otros puntos de referencia anatómicos superficiales, es imprescindible durante los abordajes posterolaterales de la fosa craneal posterior para evitar lesionar las estructuras vasculares y las complicaciones quirúrgicas. Objetivo: determinar un área anatómica de seguridad para realizar un trépano que permita ingresar en la fosa craneal posterior sin lesionar estructuras adyacentes, y estudiar las características morfométricas del asterion, el seno lateral y puntos de referencia óseos de la superficie posterolateral del cráneo. Material y métodos: estudio observacional, transversal y descriptivo efectuado en el Departamento de Anatomía Humana de las Facultad de Medicina y de Odontología de la Universidad Autónoma de Nuevo León. Se analizaron 176 hemicráneos secos, estructuralmente íntegros y sin ninguna patología o anormalidad evidente. Se utilizó una broca de 1.3 mm de diámetro con la que se perforaron ambos lados de 88 cráneos secos (176 hemicráneos). Los puntos de referencia anatómicos estudiados fueron: asterion, vértice de la apófisis mastoides, espina suprameatal, plano horizontal de Frankfurt, raíz posterior del arco cigomático, protuberancia occipital externa y su relación con el seno venoso lateral. Resultados: el asterion tipo I prevalece en 74.4% de las piezas. En 82.4% de los cráneos el seno venoso lateral se encuentra a nivel del asterion inferior a éste en 12.5% y superior en 5.1%. Conclusiones: con los datos obtenidos de esta y otras investigaciones, el trépano inicial debe situarse 15 mm por debajo del asterion inferior y 15 mm posterior a éste para disminuir los riesgos de lesión del seno venoso lateral.

  12. Measurement of the forward-backward charge asymmetry and extraction of $sin^2Theta^{eff}_W$ in $p\\bar{p} \\to Z/\\gamma^{*}+X \\to e^+e^-+X$ events produced at $\\sqrt{s}=1.96$ TeV

    SciTech Connect

    Abazov, V.M.; Abbott, B.; Abolins, M.; Acharya, B.S.; Adams, M.; Adams, T.; Aguilo, E.; Ahn, S.H.; Ahsan, M.; Alexeev, G.D.; Alkhazov, G.; /St. Petersburg, INP /Michigan U.

    2008-04-01

    We present a measurement of the forward-backward charge asymmetry (A{sub FB}) in p{bar p} {yields} Z/{gamma}* + X {yields} e{sup +}e{sup -} + X events at a center-of-mass energy of 1.96 TeV using 1.1 fb{sup -1} of data collected with the D0 detector at the Fermilab Tevatron collider. A{sub FB} is measured as a function of the invariant mass of the electron-positron pair, and found to be consistent with the standard model prediction. We use the A{sub FB} measurement to extract the effective weak mixing angle sin{sup 2} {theta}{sub W}{sup eff} = 0.2327 {+-} 0.0018 (stat.) {+-} 0.0006 (syst.).

  13. Measurement of sin2 θℓeff and Z-light quark couplings using the forward-backward charge asymmetry in pp -> Z/gamma* -> e+e- events with L=5.0 fb-1 at √s=1.96 TeV

    DOE PAGESBeta

    Abazov, V. M.

    2011-07-26

    We measure the mass dependence of the forward-backward charge asymmetry in 157,553 pp = Z/γ* = e+e- interactions, corresponding to 5.0 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider at √s = 1.96 TeV. The effective weak mixing angle (θℓeff) from this process involving predominantly the first generation of quarks is extracted as sin2 θℓeff = 0.2309 ± 0.0008 (stat.) ± 0.0006 (syst.). We also present the most precise direct measurement of the vector and axial-vector couplings of u and d quarks to the Z boson.

  14. Measurement of sin2 θeff and Z-light quark couplings using the forward-backward charge asymmetry in pp -> Z/gamma* -> e+e- events with L=5.0 fb-1 at √s=1.96 TeV

    SciTech Connect

    Abazov, V. M.

    2011-07-26

    We measure the mass dependence of the forward-backward charge asymmetry in 157,553 pp = Z/γ* = e+e- interactions, corresponding to 5.0 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider at √s = 1.96 TeV. The effective weak mixing angle (θeff) from this process involving predominantly the first generation of quarks is extracted as sin2 θeff = 0.2309 ± 0.0008 (stat.) ± 0.0006 (syst.). We also present the most precise direct measurement of the vector and axial-vector couplings of u and d quarks to the Z boson.

  15. Investigaciones en la producción orgánica de vegetales en Oklahoma, USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Nationally recognized standards for certified organic farming were established in 2002 in the United States. This action stimulated increased scientific research on production methods that can be used in certified organic growing. In 2003, a multi-disciplinary scientific team in Oklahoma that cons...

  16. Desarrollo curricular, conciencia ambiental y tecnologia para estudiantes de intermedia: Una investigacion en accion

    NASA Astrophysics Data System (ADS)

    Rodriguez Ramos, Teresita

    Se llevó a cabo una investigación en acción con los propósitos de 1) documentar las relaciones de las tecnologías de la información y la comunicación en las clases de ciencias de escuela intermedia como elemento de apoyo cuando se aborda el tema ambiental y sus conceptos pertinentes, a partir de las observaciones de la investigadora, así como las entrevistas y diarios reflexivos de los estudiantes de una escuela intermedia en la zona metropolitana, y luego 2) diseñar una unidad instruccional sobre el tema ambiental que integre actividades tecnologías para el curso de ciencias de la escuela intermedia según el modelo PROCIC y las observaciones que hayan iniciado los estudiantes participantes. Finalmente, se plantearon las implicaciones educativas para el currículo del Programa de Ciencias al instrumentar este modelo de unidad mediante PROCIC, e integrado la tecnología y el tema ambiental. Los hallazgos se analizaron y se categorizaron de acuerdo con las preguntas de investigación. El hallazgo principal de la investigación aborda las cuatro relaciones centrales en las que se articula la utilización de las tecnologías y sus aplicaciones en la clase de ciencias. Estas cuatro relaciones que recogen la posición de los estudiantes son: 1) Perspectiva de los estudiantes hacia la tecnología. 2) Participación de los estudiantes en los aspectos docentes. 3) Aprendizaje estudiantil sobre el ambiente, y 4) Conciencia ambiental en relación con la vida diaria. Estas relaciones ponen de manifiesto,cómo se plantea en las implicaciones, la necesidad de más investigación en acción en la sala de clases, la importancia—como tema transversal—de la conciencia ambiental mediante la tecnología al construir conocimientos significativos dentro y fuera de la escuela, asó como, valorar la investigación y la dialogicidad en la sala de clases como actividades que obligan al reexamen de la práctica didáctica en su formas curriculares de objetivos, recursos, actividades, evaluación, entre otros. Estos planteamientos definen la unidad curricular que se propone en el cuatro capítulo.

  17. Nueva investigacion sobre kindergarten de dia completo (Recent Research on All-Day Kindergarten). ERIC Digest.

    ERIC Educational Resources Information Center

    Clark, Patricia

    Noting that much of the early research on the effects of all-day kindergarten had serious problems with internal and external validity due to inadequate methodological standards, this Spanish-language digest reviews research conducted in the 1990s. The digest discusses the academic, social, and behavioral effects of all-day kindergarten, as well…

  18. Guia para Presentar Solcitudes de Financiacion de Investigaciones (A Guide to Requesting Financial Aid for Research).

    ERIC Educational Resources Information Center

    Ministerio de Educacion Nacional, Bogota (Colombia). Instituto Colombiano de Pedagogia.

    This booklet describes the procedures and requirements to be observed when financial support for education research is requested from the Instituto Colombiano de Pedagogia (ICOLPE), an educational improvement agency established by the Colombian government in 1968. The educational priorities for research are listed along with the rules and format…

  19. [Family. Public health workshop of the Centro de Investigaciones en Psicologia Social].

    PubMed

    Sanchez Maria Felix, B; Leon, M J

    1993-04-01

    An abbreviated primer on the sociology of the family is presented. The work defines family, describes different types of family structure, outlines the family life cycle, and discusses the functioning of families. Human beings in all societies require membership in a family of some type for reproduction and socialization. One of the most basic human needs is for a mother who will feed, protect, and instruct her offspring. Families have always changed in response to societal changes. The functions of a family are devoted to two different sets of objectives, the internal ones of psychosocial protection of the members and the external ones of accommodation to and transmission of a culture. Families in all cultures provide their members with a sense of identity. Families must respond to internal and external changes and should be capable of transforming themselves to adjust to new circumstances without losing continuity. Family systems differentiate themselves to carry out their functions through their subsystems. Individuals and dyads such as maternal-child or husband-wife are the subsystems. The family life cycle entails a series of stages: courtship, marriage, the birth and growth of children, separation of the children, retirement, old age. Each stage has its own pitfalls and challenges. Each family has a hierarchy of status and power, although in some cases the proper hierarchies are inverted, and the children carry out functions that should be completed by the parents. A series of explicit and implicit, rigid and flexible rules guide the functioning of the family. Various roles are carried out, including parental, marital, and sibling roles, as well as roles of authority, administration, and messenger.

  20. [Rural women. Public health workshop of the Centro de Investigaciones en Psicologia Social].

    PubMed

    Juarez Bartola, M; Garcia Ventura, H; De Jesus Leon, M J

    1993-04-01

    Mexico's peasant sector is undergoing great change as a result of the insertion of capitalist relations into areas that were previously remote. The traditional peasant subsistence economy has been displaced, and peasants have been forced to adopt a series of new strategies for survival, entailing proletarianization or selling of labor. Women in the community of San Nicolas Zoyapetlayoca, in the municipio of Tepeaca, have lived in a situation of poverty and precariousness for some time. Most of the population historically depended on the neighboring haciendas for their livelihood. Women and children also worked there, mistreated and without social protection. The lands that were distributed after the Revolution are insufficient to support the community, and most families must look elsewhere for employment. Incomes are insufficient to cover all the necessities of education, health, nutrition, and other aspects of life. Most women are educated no farther than the primary level. They spend most of their time preparing food, carrying water, washing clothes, caring for their children, and in other domestic chores. Some women work for wages as laborers, factory workers, or domestics. Rural women are disadvantaged by poor working conditions, insufficient education, low levels of health and nutrition, limited participation in social and political life, poor housing and lack of services, and frequently by their own attitudes of traditionalism or fatalism.

  1. Investigacion Participativa y Gestion de Sistemas Educativos. (Participatory Research and the Management of Educational Systems).

    ERIC Educational Resources Information Center

    Valle, Victor M.

    Elements which, when put in harmony, might generate powerful tools for social change and educational development are (1) the ever present need of the educational systems to evaluate their performance; (2) the universal acceptance of the life-long education concept as a major guideline to design educational programs; (3) the trend toward a…

  2. Juegos de videos: Investigacion, puntajes y recomendaciones (Video Games: Research, Ratings and Recommendations). ERIC Digest.

    ERIC Educational Resources Information Center

    Cesarone, Bernard

    This Spanish-language digest reviews research on the demographics and effects of video game playing, discusses game rating systems, and offers recommendations for parents. The digest begins by discussing research on the time children spend playing electronic games, which shows that younger children's game playing at home (90% of fourth-graders…

  3. Recopilacion Bibliografica Sobre Investigacion y Cambio Cultural (Bibliographic Compilation about Cultural Investigation and Exchange).

    ERIC Educational Resources Information Center

    Centro Latinoamericano de Educacion de Adultos, Santiago (Chile).

    The bibliography forms part of a project to define guidelines for a method of cultural investigation in the education of adults. A brief introduction is followed by a list of libraries and the plan for the listing of entries in the bibliography. Entries are arranged alphabetically by author under the following general headings: background on the…

  4. La Communicacion entre los Centros de Investigacion en Educacion (Communication among Educational Research Centers).

    ERIC Educational Resources Information Center

    Schiefelbein, Ernesto

    1972-01-01

    In Latin America there is a lack of communication concerning educational research. This lack has been underlined in many regional meetings, but no action has been taken. Possible steps that would lead to improvement include circulation of research summaries, both for completed and current works, efforts by research centers to organize meetings,…

  5. La pronunciacion espanola y los metodos de investigacion. (Spanish Pronunciation and Methods of Investigation.)

    ERIC Educational Resources Information Center

    Torreblanca, Maximo

    1988-01-01

    Discusses the validity of studies of Spanish pronunciation in terms of research methods employed. Topics include data collection in the laboratory vs. in a natural setting; recorded vs. non-recorded data; quality of the recording; aural analysis vs. spectrographic analysis; and transcriber reliability. Suggestions for improving data collection are…

  6. Metodologia de la Investigacion Participativa (The Methodology of Participatory Research). Cuadernos del CREFAL 16.

    ERIC Educational Resources Information Center

    Yopo, Boris P.

    The traditional educational method has focused on a passive stand from the learner. This passive stand can hinder creativity and analytical thinking. This work concentrates on a presentation of the Participant Research educational method. Participant Research is an adult-education method in which the learner can have an active role in his…

  7. Una Metodologia de Analisis de la Interaccion Alumno-Orgendaor en la Investigacion Sobre Informatica Educativa.

    ERIC Educational Resources Information Center

    Estepa, A.; And Others

    1992-01-01

    The recording of the interaction between pupil and computer is one of the data sources frequently used in research on the use of computers in teaching. Describes the analysis methodology of these recordings to determine the use of computers in statistics and its adaptation to other research work on the use of computers in education. (Author/MDH)

  8. Psychological well-being in a sample of obese patients compared with a control group.

    PubMed

    Magallares, Alejandro; Benito de Valle, Pilar; Irles, José Antonio; Bolaños-Ríos, Patricia; Jáuregui-Lobera, Ignacio

    2014-07-01

    INTRODUCCIÓN: La literatura ha puesto de manifiesto que los pacientes obesos suelen padecer más depresión y ansiedad que los individuos de peso normal. Sin embargo, no son muchas las investigaciones que han estudiado la relación entre obesidad y calidad de vida a partir del enfoque de la Psicología Positiva .

  9. The Critique of Impure Reason II: Sin, Science, and Society.

    ERIC Educational Resources Information Center

    Wartofsky, Marx W.

    1980-01-01

    Discusses the social role of science and the social responsibilities of scientists, along with the concomitant roles that philosophy, history, and sociology of science have in current social concerns. (CS)

  10. Sin and pleasure: the history of chocolate in medicine.

    PubMed

    Lippi, Donatella

    2015-11-18

    In ancient Mayan texts cocoa is considered a gift of the gods: Pre-Columbian populations used chocolate as medicine, too. After the discovery of America, chocolate was introduced in Europe, but Christian Europe looked to this new exhilarating drink with extreme suspiciousness and criticism. From this reaction, the necessity derived to appeal to the reasons of health, with which doctors and scientists committed themselves to explain that chocolate was good for the body. However, during the Enlightment, the road of therapy separated from that of taste, and chocolate mainly maintained its leading role of excipient, bearing the burden, over time, of a negative valence, being associated with obesity, dental problems, unhealthy lifestyle, and so forth. The rehabilitation of chocolate has arisen only in recent times, re-establishing that value that Linnaeus himself credited to chocolate, calling the generous plant Theobroma cacao, food of the gods. PMID:25989318

  11. From sin to science: fighting the stigmatization of mental illnesses.

    PubMed

    Arboleda-Flórez, Julio; Stuart, Heather

    2012-08-01

    Our paper provides an overview of current stigma discourse, the origins and nature of the stigma associated with mental illnesses, stigmatization by health providers, and approaches to stigma reduction. This is a narrative review focusing on seminal works from the social and psychological literature, with selected qualitative and quantitative studies and international policy documents to highlight key points. Stigma discourse has increasingly moved toward a human rights model that views stigma as a form of social oppression resulting from a complex sociopolitical process that exploits and entrenches the power imbalance between people who stigmatize and those who are stigmatized. People who have a mental illness have identified mental health and health providers as key contributors to the stigmatization process and worthy targets of antistigma interventions. Six approaches to stigma reduction are described: education, protest, contact-based education, legislative reform, advocacy, and stigma self-management. Stigma denigrates the value of people who have a mental illness and the social and professional support systems designed to support them. It creates inequities in funding and service delivery that undermine recovery and full social participation. Mental health professionals have often been identified as part of the problem, but they can redress this situation by becoming important partners in antistigma work. PMID:22854027

  12. In the Public Interest: Contemplating Seymour, Sin, and a Center

    ERIC Educational Resources Information Center

    Cook, Sarah L.

    2012-01-01

    In this article, the author will focus on Seymour's article titled, "And What is the Public Interest?" (Sarason, 1986). To the author, the core of the article is as follows: "And what is the public interest? At its phenomenological root it is a picture of a triad: the individual, the society, and the bases on which they give meaning to each other.…

  13. The Trauma of Racism: America's Original Sin

    ERIC Educational Resources Information Center

    Ponds, Kenneth T.

    2013-01-01

    With the election of Barack Obama as President, many believed that this nation was entering into a post-racial America, a color-blind society where racism could begin to be healed if not totally dismissed. However, a recent Associated Press poll has shown that this is not the case (AP, 2012). In fact, racial prejudice has increased slightly since…

  14. The UNSIN Project: Exploring the Molecular Physiology of Sins

    ERIC Educational Resources Information Center

    Naji, Faysal; Salci, Lauren; Hoit, Graeme; Rangachari, P. K.

    2012-01-01

    Although active learning works, promoting it in large undergraduate science classes is difficult. Here, three students (F. Naji, L. Salci, and G. Hoit) join their teacher (P. K. Rangachari) in describing one such attempt. Two cohorts in a first-year undergraduate biology course explored the molecular underpinnings of human misbehavior. Students…

  15. Driven to drink: Sin taxes near a border.

    PubMed

    Beatty, Timothy K M; Larsen, Erling Røed; Sommervoll, Dag Einar

    2009-12-01

    This paper investigates household purchasing behavior in response to differing alcohol and tobacco taxes near an international border. Our study suggests that large tax differentials near borders induce economically important tax avoidance behavior, which may limit a government's ability to raise revenue and potentially undermine important health and social policy goals. We match novel supermarket scanner and consumer expenditure data to measure the size and scope of the effect for households and stores. We find that stores near/far from the international border have statistically significantly lower/higher sales of beer and tobacco than comparable stores far/near the border. Moreover, we find that households near the border report higher consumption of these same goods. This is consistent with households facing lower prices. Finally, we find measures of externalities associated with these goods are higher near the border.

  16. Going Too Far?: Sex, Sin and Social Policy

    ERIC Educational Resources Information Center

    Rose, Susan

    2005-01-01

    This paper examines the impact of the Religious Right on American social policy as it relates to family, sexuality and reproductive health. The article focuses on the current debates and practices of abstinence-until-marriage programs vs. comprehensive sex education programs--and the ways in which they reflect and affect cultural attitudes about…

  17. From Right to Sin: Laws on Infanticide in Antiquity.

    PubMed

    Obladen, Michael

    2016-01-01

    This is the first of three papers investigating changes in infanticide legislation as indicators of the attitude of states towards the neonate. In ancient East Asian societies in which the bride's family had to pay an excessive dowry, selective female infanticide was the rule, despite formal interdiction by the law. In Greece and Rome children's lives had little value, and the father's rights included killing his own children. The proportion of men greatly exceeding that of women found in many cultures and epochs suggests that girls suffered infanticide more often than boys. A kind of social birth, the ritual right to survive, rested on the procedure of name giving in the Roman culture and on the start of oral feeding in the Germanic tradition. Legislative efforts to protect the newborn began with Trajan's 'alimentaria' laws in 103 CE and Constantine's laws following his conversion to Christianity in 313 CE. Malformed newborns were not regarded as human infants and were usually killed immediately after birth. Infanticide was formally outlawed in 374 CE by Emperor Valentinian.

  18. The Seven Deadly Sins of Public Outreach Programs.

    ERIC Educational Resources Information Center

    Miller, Kivi Leroux

    2003-01-01

    Lists seven approaches not to take when developing a public outreach campaign on recycling. Methods include: (1) environmental education will increase participation; (2) everyone cares about recycling; (3) guilt works; (4) keep repeating the same ads; (5) non-English speakers need translated literature; (6) scheduling workshops; and (7) kids will…

  19. Twelve mortal sins of the turbulence propagation science

    NASA Astrophysics Data System (ADS)

    Charnotskii, Mikhail

    2011-09-01

    In this review paper we discuss a series of typical mistakes and omissions that are made by engineers and scientists involved in the theoretical research and modeling of the optical propagation through atmospheric turbulence. We show how the use of the oversimplified Gaussian spectral model of turbulence delivers the completely erroneous results for the beam wander. We address a series of common omissions related to calculations of the average beam intensity: unnecessary use of the approximations when rigorous result is available, invalid application of the RMS beam size to the turbulence-distorted beams, overlooking the simple theoretical result - average beam intensity is a convolution with the turbulent Point Spread Function (PSF). We discuss the meaning and potential dangers of the use of the quadratic structure function for modeling of the turbulent perturbations. We will also address the issues related to the energy conservation principle and reciprocity that have very important consequences for the turbulence propagation, but are frequently overlooked in the current literature. We discuss a series of misconceptions that very common in of the Scintillation Index (SI) calculations. We will clarify the infamous misunderstanding of the Rytov's approximation: vanishing scintillation at the beam focus, and show the correct weak and strong scintillation solutions for the SI at the beam focus. We discuss the flaws of the Fried model of the short-term PSF, and direct to the more accurate PSF model. We will briefly review the propagation of the polarized optical waves through turbulence and discuss the inadequacy of the recently published calculations of the electromagnetic beams calculations. We discuss some common errors in representation of the calculation results for the non-Kolmogorov turbulence.

  20. The Problem of Propagation: Original Sin as Inherited Discourse

    ERIC Educational Resources Information Center

    Stillwaggon, James

    2014-01-01

    As Modernist doctrines emphasizing the unity and agency of the educated self are increasingly set up as the straw men of contemporary educational discourses, premodern and Medieval theories of selfhood tend to disappear from the horizon of educational thought altogether. In this essay, in order to subvert this overcoming of our intellectual past,…

  1. Recent Measurements of sin2beta at BaBar

    SciTech Connect

    Sciolla, Gabriella; /MIT

    2005-12-14

    The angle {beta} is the most accurately measured quantity that determines the Unitarity Triangle. In this article I review the various measurements of this angle performed by the BaBar Collaboration, and discuss their implications in the search for new physics.

  2. Sin, Sickness or Status? Homosexual Gender Identity and Psychoneuroendocrinology.

    ERIC Educational Resources Information Center

    Money, John

    1987-01-01

    Sex hormones in the prenatal brain of humans influence the subsequent sexual status or orientation of the individual as bisexual, heterosexual, or homosexual. Postnatal socialization is another contributing factor. Sexual orientation is not under the direct governance of chromosomes and genes. (Author/VM)

  3. Sin and pleasure: the history of chocolate in medicine.

    PubMed

    Lippi, Donatella

    2015-11-18

    In ancient Mayan texts cocoa is considered a gift of the gods: Pre-Columbian populations used chocolate as medicine, too. After the discovery of America, chocolate was introduced in Europe, but Christian Europe looked to this new exhilarating drink with extreme suspiciousness and criticism. From this reaction, the necessity derived to appeal to the reasons of health, with which doctors and scientists committed themselves to explain that chocolate was good for the body. However, during the Enlightment, the road of therapy separated from that of taste, and chocolate mainly maintained its leading role of excipient, bearing the burden, over time, of a negative valence, being associated with obesity, dental problems, unhealthy lifestyle, and so forth. The rehabilitation of chocolate has arisen only in recent times, re-establishing that value that Linnaeus himself credited to chocolate, calling the generous plant Theobroma cacao, food of the gods.

  4. Preventing Sin: The Ethics of Vaccines against Smoking

    PubMed Central

    Lieber, Sarah R.; Millum, Joseph

    2016-01-01

    Advances in immunotherapy are paving the way toward vaccines that target unhealthy behaviors, such as a vaccine that blocks the action of nicotine, reducing the pleasure caused by smoking. Such a tool could prove to be an effective tool for preventing children from taking up smoking. Would it be permissible? PMID:23650065

  5. Capacitively Coupled Hot-Electron Nanobolometer with SIN Tunnel Junctions

    NASA Astrophysics Data System (ADS)

    Kuzmin, Leonid S.; Fominsky, M.; Kalabukhov, A.; Golubev, D.; Tarasov, M.

    2003-02-01

    A capacitively coupled hot-electron nanobolometer (CC-HEB) is the simplest and most effective antenna-coupled bolometer. The bolometer consists of a small absorber connected to the superconducting antenna by tunnel junctions. The tunnel junctions used for high-frequency coupling also give perfect thermal isolation of hot electrons in the small volume of the absorber. The same tunnel junctions are used for temperature measurements and electron cooling. This bolometer does not suffer from the frequency limitations in the submillimeter range due to the high potential barrier of the tunnel junctions as does the microbolometer with Andreev mirrors (A-HEB), which is limited by the superconducting gap. Theoretical analyses show that the two-junction configuration more than doubles the sensitivity of the bolometer in current-biased mode compared to the single-junction configuration used for A-HEB. Another important advantage of CC-HEB is its simple two-layer technology for sample fabrication. Samples were fabricated with an absorber made of a bilayer of Cr and Al to match the impedance of the antenna. Electrodes were made of Al and tunnel junctions were formed over the Al oxide layer. The coupling capacitances of the tunnel junctions, C ≍ 20 fF, in combination with the inductance of the 10 μm absorber create a bandpass filter with a central frequency around 300 GHz. Bolometers are integrated with log-periodic and double-dipole planar antennas made of Au. The temperature response of bolometer structures was measured at temperatures down to 256 mK. In our experiment we observed dV/dT=1.3 mV/K, corresponding to responsivity S=0.2.109 V/W. For amplifier noise Vna=3nV/Hz1/2 at 1 kHz the estimated total noise equivalent power is NEP=1.5.10-17 W/Hz1/2. The intrinsic bolometer self noise Vnbol=0.5 nV/Hz1/2 corresponds to NEP=3.10-18 W/Hz1/2. For microwave evaluation of bolometer sensitivity we used a black body radiation source comprising a thin NiCr stimulator placed on the cold plate of cryostat in front of a CC-HEB attached to an extended hemisphere sapphire lens. This measurements were consistent with estimates based on the dc responsivity of the bolometer.

  6. Thinking before sinning: reasoning processes in hedonic consumption

    PubMed Central

    de Witt Huberts, Jessie; Evers, Catharine; de Ridder, Denise

    2014-01-01

    Whereas hedonic consumption is often labeled as impulsive, findings from self-licensing research suggest that people sometimes rely on reasons to justify hedonic consumption. Although the concept of self-licensing assumes the involvement of reasoning processes, this has not been demonstrated explicitly. Two studies investigated whether people indeed rely on reasons to allow themselves a guilty pleasure. Participants were exposed to a food temptation after which passive and active reasoning was assessed by asking participants to indicate the justifications that applied to them for indulging in that temptation (Study 1) or having them construe reasons to consume the hedonic product (Study 2). Regression analyses indicated that higher levels of temptation predicted the number of reasons employed and construed to justify consumption. By providing evidence for the involvement of reasoning processes, these findings support the assumption of self-licensing theory that temptations not only exert their influence by making us more impulsive, but can also facilitate gratification by triggering deliberative reasoning processes. PMID:25408680

  7. Sins of Omission and Commission: To Proceed, Decline, or Alter?

    ERIC Educational Resources Information Center

    Birman, Dina

    2007-01-01

    The article addresses a hypothetical dilemma confronted by an evaluator of a transition from welfare program regarding inclusion of a small immigrant/language minority group in the study. The article advocates for inclusion of diverse groups. Three important aspects of diversity are discussed that have particular relevance to transition from…

  8. [Characteristics of diabetes mellitus patients under a chronic disease program].

    PubMed

    López, Ana Cristina; Aguirre, Ana Noemi; Roitter, Claudia Valentina; Aguirre, Jorge Alberto; Cecchetto, Eugenio; Bernet, Jorgelina; García, Adelaida Judith; Mantaras, José

    2015-01-01

    La Diabetes Mellitus (DM) es una enfermedad crónica no transmisible con una prevalencia en Argentina del 9,8%. El seguimiento de pacientes con DM se realiza en un Programa de Enfermedades Crónicas desarrollado en la obra social universitaria DASPU, de la Universidad Nacional de Córdoba Argentina. Objetivo: describir características clínicas de personas con DM de un programa de seguimiento. Identificar variables de control metabólico asociadas a la presencia de complicaciones. Material y método. Estudio observacional, transversal, descriptivo. Se incluyeron datos de pacientes con DM bajo programa del año 2010. Las variables categóricas se describen como proporciones y las numéricas como media ±DE. La comparación de medias se realizó mediante test de Student. Resultados: total 1017 casos, edad media 61 ±14 años, 54,6% masculinos, DM tipo 1: 8,5%, DM tipo 2: 90,9%, DM gestacional: 0,7%. Factores de riesgo cardiovascular: hipertensión arterial en 78%, dislipemia en 35%. Complicaciones microvasculares: 25,5%, macrovasculares: 18,6%. La enfermedad coronaria fue la complicación más frecuente: 14,5%. El 69% presentó valores de hemoglobina glicosilada (HbA1C) ≤7,4%; el promedio de colesterol total fue 185 mg/dl y de colesterol LDL 111 mg/dl. El promedio de HbA1C fue más elevado en pacientes con complicaciones microvasculares que sin complicaciones: 7,47% vs 7,18% (p=0,009). En pacientes con complicaciones macrovasculares hubo una tendencia inversa, no significativa (7,21% vs 7,26%; p=0,65). El promedio de colesterol total fue menor en el grupo con complicaciones macrovasculares (173 mg/dl vs 189 mg/dl; p=0,001). Igual comportamiento se observó en relación al C-LDL (101 vs 113 mg/dl; p=0,001). Conclusión: Las características clínicas evaluadas coinciden en su distribución y complicaciones con estudios epidemiológicos reportados en la bibliografía, los valores de HbA1C y colesterol total alcanzan valores óptimos en un gran porcentaje de nuestra

  9. [Parenteral nutrition in pediatric patients: indications and complications in third level].

    PubMed

    Ríos-González, Roxana; Anaya-Florez, María Salomé; Gutiérrez-Hernández, Jorge Isaac; Morán-Villota, Segundo

    2015-01-01

    Introducción: la nutrición parenteral (NP) es una mezcla que cubre las necesidades nutricionales cuando no es posible lograr esta tarea por la vía enteral en el paciente; sin embargo, no está exenta de complicaciones. El objetivo del estudio fue conocer la indicación y la frecuencia de complicaciones de la NP en pacientes pediátricos atendidos en un centro de tercer nivel. Métodos: se incluyeron niños que recibieron NP en el Hospital de Pediatría del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social. Se registraron las características demográficas, antropométricas, la causa de la indicación de la NP, su tiempo de administración y las complicaciones asociadas a este tipo de nutrición. Resultados: se incluyeron 69 pacientes pediátricos: 33 recién nacidos (RN) y 18 lactantes entre uno y 11 meses de edad; nueve preescolares entre uno y cinco años, y nueve niños mayores de cinco años. Las enfermedades del tracto digestivo tratadas quirúrgicamente constituyeron el 71 % de las indicaciones para el inicio de NP. Se presentaron complicaciones en el 87 % de los pacientes y 76.7% tuvieron más de una complicación. Las complicaciones metabólicas representaron 98 %, las mecánicas 1 % y las infecciosas 1 %. Conclusión: la NP en este centro de tercer nivel se indicó principalmente a pacientes sometidos a cirugía del tracto digestivo.

  10. Fundamentos, Orientaciones, Areas Basicas y Procedimientos para la Investigacion Educativa (Bases, Guidelines, Basic Areas, and Procedures for Educational Research).

    ERIC Educational Resources Information Center

    Ministerio de Educacion Nacional, Bogota (Colombia). Instituto Colombiano de Pedagogia.

    This document establishes the bases, general guidelines, basic areas, and procedures for educational research conducted in Colombia. The philosophy underlying research objectives is explained. There is special interest in social research concerning the condition of man and of the social groups that will be the targets of education, and in research…

  11. Guia para la Elaboracion y Evaluacion de Proyectos de Investigacion (Guidelines for Reporting and Evaluating Research Projects).

    ERIC Educational Resources Information Center

    Morles, Victor

    This article establishes guidelines for conducting and evaluating research projects according to a scientific methodology. The organizational format suggested here follows an outline with elements and details that should be considered in an investigation. Each part of the proposed outline is explained, and terms are defined. Project evaluation is…

  12. La investigacion sovietica en psicologia de la actividad linguistica (Soviet Investigations in Psychology Relating to Linguistic Processes)

    ERIC Educational Resources Information Center

    Prucha, J.

    1975-01-01

    Surveys the actual state of Russian research on verbal behavior as seen from the field of psychology. The research is in four parts: (1) language and thought, especially internal language, (2) neurological aspects of language, (3) child language, and (4) psychology of language learning and teaching for native and foreign languages. (Text is in…

  13. La Investigacion Participativa en America Latina: Retablo de Papel, 10 (Participatory Research in Latin America: Series, 10).

    ERIC Educational Resources Information Center

    Vejarano, Gilberto M., Comp.

    The following papers (titles are translated into English) were presented at a conference on participatory research: "Participatory Research, Popular Knowledge, and Power"; "Participatory Research and Adult Literacy"; "Developments and Perspectives on Participatory Research"; "Popular Education and Participatory Research"; "The Researcher and the…

  14. Idiomas, Escuelas y Radios en Bolivia. Cuadernos de Investigacion 3. (Languages, Schools and Radios in Bolivia. Investigative Notes Number 3).

    ERIC Educational Resources Information Center

    Albo, Javier

    Bolivia has a multilingual population divided among three language families: Spanish, Quechua, and Aymara. In practice, however, the country has a monolingual system, since Spanish is the language of government, education, and professional and technical fields, and dominates in urban areas. Quechua and Aymara prevail in rural areas and in native…

  15. An Evaluation of the BKB-SIN, HINT, QuickSIN, and WIN Materials on Listeners with Normal Hearing and Listeners with Hearing Loss

    ERIC Educational Resources Information Center

    Wilson, Richard H.; McArdle, Rachel A.; Smith, Sherri L.

    2007-01-01

    Purpose: The purpose of this study was to examine in listeners with normal hearing and listeners with sensorineural hearing loss the within- and between-group differences obtained with 4 commonly available speech-in-noise protocols. Method: Recognition performances by 24 listeners with normal hearing and 72 listeners with sensorineural hearing…

  16. [Complications related with implanted devices in patients with Parkinson's disease treated with deep brain stimulation. A study of a series of 124 patients over a period of 16 years].

    PubMed

    de Quintana-Schmidt, C; Pascual-Sedano, Berta; Alvarez-Holzapfel, M Jesús; Gironell, Alexandre; Leidinger, Andreas; Benito, Natividad; Rodríguez-Rodríguez, Rodrigo; Molet-Teixidó, Joan

    2014-07-16

    Introduccion. La protocolizacion de los mejores candidatos para la estimulacion cerebral profunda en pacientes con enfermedad de Parkinson y el mayor conocimiento de la tecnica han aumentado su perfil de seguridad. Sin embargo, las complicaciones relacionadas con los dispositivos implantados siguen teniendo una frecuencia no menospreciable y presentan un impacto tanto clinico como economico. Objetivo. En una serie amplia de pacientes con estimulacion cerebral profunda incluidos consecutivamente para el tratamiento de su enfermedad de Parkinson, se recogieron las complicaciones relacionas con los dispositivos implantados y se compararon con la bibliografia. Pacientes y metodos. Se incluyeron en el estudio 124 pacientes con un total de 242 electrodos implantados y 252 recambios de generador. Seguimiento medio de 8,4 años (rango: 3-16 años). Se recogieron de forma retrospectiva todas las complicaciones relacionadas con los dispositivos implantados. Resultados. Se produjeron 23 complicaciones relacionadas con los dispositivos implantados (el 17,7% de los pacientes): 12 (9,6%) ulceras con cultivo positivo, cinco (4%) ulceras con cultivo negativo, cuatro (3,2%) infecciones tras recambio de generador, una (0,8%) malfuncion de generador y una (0,8%) migracion del electrodo. Se observaron diferencias significativas respecto a la efectividad del tratamiento de la revision quirurgica de las ulceras, lo que indica que las ulceras con cultivo negativo respondieron mejor que las ulceras con cultivo positivo a la revision quirurgica (80% frente a 16,6% de curacion; p = 0,028). Conclusiones. Se observan en la serie unos resultados comparables a la bibliografia existente. La presencia de positividad en el cultivo de las ulceras constituye un factor pronostico a la revision quirurgica.

  17. [Survival and complication rate of central venous catheters in newborns].

    PubMed

    García, Heladia Josefa; Torres-Yáñez, Héctor Leonardo

    2015-01-01

    Introducción: los catéteres venosos centrales (CVC) son de gran utilidad en la práctica médica actual; sin embargo, no están exentos de riesgos, lo que incrementa la morbilidad y mortalidad, especialmente en los recién nacidos (RN). El objetivo fue registrar la frecuencia de complicaciones de los CVC y su duración en RN en una unidad de cuidados intensivos neonatales (UCIN) de tercer nivel. Métodos: se realizó un estudio observacional descriptivo, prolectivo en la UCIN del Hospital de Pediatría del Centro Médico Nacional Siglo XXI. Se registraron variables demográficas, perinatales y del CVC. Resultados: se incluyeron 123 RN a quienes se les colocaron 152 CVC. La técnica más usada para la inserción del CVC fue la punción (percutánea o subclavia) en 56.6 % (n = 86). En 48.7 % (n = 74) de los CVC se presentó alguna complicación. Las más frecuentes fueron colonización en 32.4 % (n = 24) y bacteriemia relacionada con CVC en 27 % (n = 20). La probabilidad de duración de los CVC libres de complicaciones fue de 93.4 % a los 10 días y de 91.4 % a los 17 días. Los catéteres venosos no centrales tuvieron menor probabilidad de duración. Conclusión: la mayoría de las complicaciones de los CVC se presentaron en las primeras dos semanas de haber sido instalados. Las complicaciones infecciosas fueron las más frecuentes.

  18. Materials Data on Ca5(SiN3)2 (SG:15) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  19. Escuelas sin Drogas. Como Actuar. Edicion 1992. (Schools without Drugs. What Works. 1992 Edition).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    Across the United States, schools and communities have found ways to turn the tide in the battle against drugs. This guidebook describes the methods they have used and the actions they have taken. The first section, "Children and Drugs" outlines the nature and extent of the drug problem and summarizes the latest research on the effects of drugs on…

  20. The Great Sexologists: John Money on Sin, Science, and the Sex Police.

    ERIC Educational Resources Information Center

    Money, John

    This paper discusses the role of sex police in society from the 14th century to the present and their affect on sex education in the schools. Jean Gerson, Chancellor of the University of Paris and Dean of the Cathedral School of Notre Dame, was one of the first to publish information concerning nocturnal wet dreams and boyhood masturbation. His…

  1. Seven deadly sins of childhood: advising parents about difficult developmental phases.

    PubMed

    Schmitt, B D

    1987-01-01

    Seven of the more difficult developmental phases for any parent to deal with are colic, awakening at night, separation anxiety, normal exploratory behavior, normal negativism, normal poor appetite, and toilet training resistance. For the child living in a high-risk family, these innocent acts can trigger dangerous or even deadly abuse. The two behaviors most commonly associated with fatal abuse are colic and toilet training. When we recognize a child who is going through a provocative phase, we should be prepared to advise the parents on some practical alternatives to a physical response. Such advice is welcomed by most types of families. Any treatment plan for an abusive family that fails to include this type of problem solving may be inadequate.

  2. America's Original Sin. A Study Guide on White Racism. New, Expanded Edition.

    ERIC Educational Resources Information Center

    Hulteen, Bob, Ed.; Wallis, Jim, Ed.

    This study guide offers 53 essays and articles in 9 study sessions on the causes and consequences of racism and a vision for change from a Christian perspective. The guide is updated to include articles addressing issues raised by the riots in Los Angeles (California), the 25th anniversary of the legislative victories of the Civil Rights Movement,…

  3. Sex, Sin, and Swaggart: Conflict-Management through the Rhetoric of Compliance-Gaining Apologia.

    ERIC Educational Resources Information Center

    Arnold, Christa L.; Fadely, Dean

    Television evangelist Jimmy Swaggart's public speech of apology following revelations of his sexual relationship with a prostitute provides the basis for a study of the rhetorical genres of apologia and compliance-gaining discourse. Apologia is public speech used by prominent persons to repair damage done to their reputations by allegations of…

  4. Control of recoil losses in nanomechanical SiN membrane resonators

    NASA Astrophysics Data System (ADS)

    Borrielli, A.; Marconi, L.; Marin, F.; Marino, F.; Morana, B.; Pandraud, G.; Pontin, A.; Prodi, G. A.; Sarro, P. M.; Serra, E.; Bonaldi, M.

    2016-09-01

    In the context of a recoil damping analysis, we have designed and produced a membrane resonator equipped with a specific on-chip structure working as a "loss shield" for a circular membrane. In this device the vibrations of the membrane, with a quality factor of 107, reach the limit set by the intrinsic dissipation in silicon nitride, for all the modes and regardless of the modal shape, also at low frequency. Guided by our theoretical model of the loss shield, we describe the design rationale of the device, which can be used as effective replacement of commercial membrane resonators in advanced optomechanical setups, also at cryogenic temperatures.

  5. Operation of bolometer system using Pt foil on SiN substrate detector for EAST tokamak

    NASA Astrophysics Data System (ADS)

    Duan, Y. M.; Mao, S. T.; Hu, L. Q.; Xu, P.; Xu, L. Q.; Zhang, J. Z.; Lin, S. Y.

    2016-11-01

    The foil resistive bolometer diagnostic on experimental advanced superconducting tokamak has been upgraded partly with a new generation of detectors. The new detectors have faster response time. However, the microwave interference is still a serious issue for the bolometer system. The system response to microwave is tested, and the test results show that the closed Wheatstone bridge circuit in the detector is the most sensitive component to high power microwave field. Simulation results of microwave transmission by the high frequency structure simulator software and shielding design are also presented.

  6. Renovando la Esperanza por una Educacion sin Exclusiones (Rekindling the Hope for an Education without Exclusion).

    ERIC Educational Resources Information Center

    Revista Interamericana de Educacion de Adultos, 2001

    2001-01-01

    Articles in this issue, written in Spanish, focus on the following: current status and outlook of youth and adult education; opening statement of the 50th anniversary commemoration; regional framework for the education of youth and adults in Latin America and the Caribbean; interculturalism and the education of youth and adults; participation of…

  7. A People-Based Approach to OBM: Synergy, Not "Sin"-ergy

    ERIC Educational Resources Information Center

    Wiegand, Douglas M.

    2005-01-01

    This rejoinder discusses some common points raised in the commentaries of this special issue of JOBM, including (1) different definitions of positive and negative, (2) use of the terms reinforcement and establishing operation, and (3) concerns over the abandonment of behavior analysis for mentalistic research. In addition, a people-based approach…

  8. Fascinating Machismo: Toward an Unmasking of Heterosexual Masculinity in Arturo Ripstein's "El Lugar sin Limites."

    ERIC Educational Resources Information Center

    de la Mora, Sergio

    1993-01-01

    Provides a genealogy of the "fichera" (cabaret dancer/prostitute) genre in Mexican cinema, moving from the figure of the female prostitute to that of the "queen" homosexual type. Discusses the ideological function of homosexual stereotyping and to the way the queen homosexual stereotype is deployed to very different ends in Arturo Ripstein's film…

  9. Sin Verguenza: Addressing Shame with Latino Victims of Child Sexual Abuse and Their Families

    ERIC Educational Resources Information Center

    Fontes, Lisa Aronson

    2007-01-01

    This article explores shame issues for Latino children who have been sexually abused and their families. Latino cultural concerns around shame that are associated with sexual abuse include: attributions for the abuse, fatalism, virginity, sexual taboos, predictions of a shameful future, revictimization, machismo, and fears of homosexuality for boy…

  10. Of neoliberalism and global health: human capital, market failure and sin/social taxes

    PubMed Central

    Reubi, David

    2016-01-01

    Abstract This article tells a different but equally important story about neoliberalism and global health than the narrative on structural adjustment policies usually found in the literature. Rather than focus on macroeconomic structural adjustment policies, this story draws our attention to microeconomic taxation policies on tobacco, alcohol and sugar now widely recognised as the best strategy to control the global non-communicable disease epidemic. Structural adjustment policies are the product of the shift from statist to market-based development models, which was brought about by neoliberal thinkers like Peter Blau and Deepak Lal. In contrast, taxation policies are the result of a different epistemological rupture in international development: the move from economies and physical capital to people and human capital, advocated by Gary Becker and others. This move was part of wider change, which saw Chicago School economists, under the influence of rational choice theory, redefine the object of their discipline, from the study of markets to individual choices. It was this concern with people and their choices that made it possible for Becker and others to identify the importance of price for the demand for tobacco, alcohol and sugar. The same concern also made it easier for them to recognise that there were inefficiencies in the tobacco, alcohol and sugar markets that required government intervention. This story, I suggest, shows that structural adjustment policies and pro-market ideology do not exhaust the relationship between neoliberalism and global health and should not monopolise how we, as political and social scientists, conceive it. PMID:27721572

  11. The myth of harmless wrongs in moral cognition: Automatic dyadic completion from sin to suffering.

    PubMed

    Gray, Kurt; Schein, Chelsea; Ward, Adrian F

    2014-08-01

    When something is wrong, someone is harmed. This hypothesis derives from the theory of dyadic morality, which suggests a moral cognitive template of wrongdoing agent and suffering patient (i.e., victim). This dyadic template means that victimless wrongs (e.g., masturbation) are psychologically incomplete, compelling the mind to perceive victims even when they are objectively absent. Five studies reveal that dyadic completion occurs automatically and implicitly: Ostensibly harmless wrongs are perceived to have victims (Study 1), activate concepts of harm (Studies 2 and 3), and increase perceptions of suffering (Studies 4 and 5). These results suggest that perceiving harm in immorality is intuitive and does not require effortful rationalization. This interpretation argues against both standard interpretations of moral dumbfounding and domain-specific theories of morality that assume the psychological existence of harmless wrongs. Dyadic completion also suggests that moral dilemmas in which wrongness (deontology) and harm (utilitarianism) conflict are unrepresentative of typical moral cognition.

  12. Who Sinned? Parents' Knowledge of the Causes of Disability in Tanzania

    ERIC Educational Resources Information Center

    Tungaraza, Frida D.

    2012-01-01

    This study aimed at finding out from parents what they knew to be the causes of their children's disabilities. One hundred and twenty six parents from four regions, namely Dar es Salaam, Dodoma, Kilimanjaro and Morogoro were involved in this study. Data was collected through interview, narratives and observation. It was obvious from the findings…

  13. Materials Data on Li2SiN2 (SG:61) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  14. Mastery Without Mystery: Why there is no Promethean Sin in Enhancement

    PubMed Central

    Kahane, Guy

    2011-01-01

    Several authors have suggested that we cannot fully grapple with the ethics of human enhancement unless we address neglected questions about our place in the world, questions that verge on theology but can be pursued independently of religion. A prominent example is Michael Sandel, who argues that the deepest objection to enhancement is that it expresses a Promethean drive to mastery which deprives us of openness to the unbidden and leaves us with nothing to affirm outside our own wills. Sandel's argument against enhancement has been criticized, but his claims about mastery and the unbidden, and their relation to religion, have not yet received sufficient attention. I argue that Sandel misunderstands the notions of mastery and the unbidden and their significance. Once these notions are properly understood, they have surprising implications. It turns out that the value of openness to the unbidden is not just independent of theism, as Sandel claims, but is in fact not even fully compatible with it. But in any case that value cannot support Sandel's objection to enhancement. This is because it is not enhancement but certain forms of opposition to enhancement that are most likely to express a pernicious drive to mastery. PMID:22318775

  15. Sequencing Antibody Repertoires Provides Evidence for Original Antigenic Sin Shaping the Antibody Response to Influenza Vaccination

    PubMed Central

    Tan, Yann-Chong; Scalfone, Lisa K.; Kongpachith, Sarah; Ju, Chia-Hsin; Cai, Xiaoyong; Lindstrom, Tamsin M.; Sokolove, Jeremy; Robinson, William H.

    2014-01-01

    We used a DNA barcoding method to enable high-throughput sequencing of the cognate heavy- and light-chain pairs of expressed antibodies. We used this approach to elucidate the plasmablast antibody response to influenza vaccination. We show that >75% of the rationally selected plasmablast antibodies bind and neutralize influenza, and that antibodies from clonal families, defined by sharing both heavy chain VJ and light chain VJ sequence usage, do so most effectively. Vaccine-induced heavy chain VJ regions contained on average >20 nucleotide mutations as compared to their predicted germline gene sequences, and some vaccine-induced antibodies exhibited higher binding affinities for hemagglutinins derived from prior years’ seasonal influenza as compared to their affinities for the immunization strains. Our results show that influenza vaccination induces the recall of memory B cells that express antibodies that previously underwent affinity maturation against prior years’ seasonal influenza, suggesting that ‘original antigenic sin’ shapes the antibody response to influenza vaccination. PMID:24525048

  16. Materials Data on S(IN)2 (SG:2) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  17. A highly sensitive refractometric sensor based on cascaded SiN microring resonators.

    PubMed

    Zamora, Vanessa; Lützow, Peter; Weiland, Martin; Pergande, Daniel

    2013-01-01

    We investigate a highly sensitive optical sensor based on two cascaded microring resonators exploiting the Vernier effect. The architecture consists of two microrings with a slight difference in their free spectral ranges. This allows the generation of the Vernier effect for achieving ultra-high sensitivities. The sensor chip was fabricated using a silicon nitride platform and characterized with isopropanol/ethanol mixtures. A sensitivity of 0.95 nm/% was found for isopropanol concentrations in ethanol ranging from 0% to 10%. Furthermore, a collection of measurements was carried out using aqueous sodium chloride (NaCl) in solutions of different concentrations, confirming a high sensitivity of 10.3 nm/% and a bulk refractive index sensitivity of 6,317 nm/RIU. A limit of detection of 3.16 × 10(-6) RIU was determined. These preliminary results show the potential features of cascaded silicon nitride microring resonators for real-time and free-label monitoring of biomolecules for a broad range of applications. PMID:24169543

  18. Measurements of sin2beta at BaBar with Charmonium and Penguin Decays

    SciTech Connect

    George, Katherine A.; /Liverpool U.

    2005-12-14

    This article summarizes measurements of time-dependent CP asymmetries in decays of neutral B mesons to charmonium, open-charm and gluonic penguin-dominated charmless final states. Unless otherwise stated, these measurements are based on a sample of approximately 230 million {Upsilon}(4S) {yields} B{bar B} decays collected by the BABAR detector at the PEP-II asymmetric-energy B-factory.

  19. Measurements of sin2{beta} at BABAR with charmonium and penguin decays

    SciTech Connect

    George, Katherine

    2006-07-11

    This article summarises measurements of time-dependent CP asymmetries in decays of neutral B mesons to charmonium, open-charm and gluonic penguin-dominated charmless final states. Unless otherwise stated, these measurements are based on a sample of approximately 230 million {upsilon}(4S){yields} BB(bar sign) decays collected by the BABAR detector at the PEP-II asymmetric-energy B -factory.

  20. Fully Si compatible SiN resistive switching memory with large self-rectification ratio

    NASA Astrophysics Data System (ADS)

    Kim, Sungjun; Cho, Seongjae; Park, Byung-Gook

    2016-01-01

    In this letter, we report unique unipolar resistive switching memory behaviors in the Ni/Si3N4/p-Si structure by controlling the impurity concentration of Si bottom electrode. It is found that we can decrease the reset current drastically by reducing dopant concentration by reducing dopant concentration, which helps low-power operation in the high density resistive switching memory array. Also, the samples with high impurity concentration exhibited ohmic conduction in the low-resistance state (LRS) while those with low dopant concentration below 1018 cm-3 showed a remarkable self-rectifying behavior. The nonlinear metal-insulator-semiconductor (MIS) diode characteristics in the samples with low doping concentration (˜1018 cm-3) are explained by the formation of Schottky barrier at the metal and semiconductor interface. As a result, we demonstrate high rectification ratio (>105) between forward and reverse currents along with the robust nonvolatile properties including endurance cycles and retention from the devices with large self-rectification ratio. The high self-rectifying characteristics of Si3N4-based RRAM cell would be one of the most virtuous merits in the high-density crossbar array.

  1. BaBar: sin(2beta) with Charmless and Radiative Decays

    SciTech Connect

    Dujmic, Denis; /SLAC

    2006-02-27

    We present new measurements of time-dependent CP-violation parameters in hadronic penguin decays: B{sup 0} {yields} K{sup +}K{sup -}K{sub L}{sup 0}, K{sub S}{sup 0}{pi}{sup 0}{pi}{sup 0}, K{sub S}{sup 0}K{sub S}{sup 0}K{sub S}{sup 0}, {omega}K{sub L}{sup 0}, and a radiative penguin decay B{sup 0} {yields} K{sub S}{sup 0}{pi}{sup 0}{gamma} in a dataset of around 230 {center_dot} 10{sup 6} B{bar B} pairs collected by the BABAR detector at the asymmetric B Factory at SLAC. These CP asymmetry measurements probe for amplitudes beyond the Standard Model in loop-dominated decays of neutral B mesons. While we find a puzzling deviation of CP-asymmetry parameters from predicted values, a full confirmation still awaits more data.

  2. Materials Data on Ba5(SiN3)2 (SG:19) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  3. Living in Sin? How Gay Catholics Manage Their Conflicting Sexual and Religious Identities.

    PubMed

    Pietkiewicz, Igor J; Kołodziejczyk-Skrzypek, Monika

    2016-08-01

    Religious principles and values provide meaning and affect personal identity. They may also conflict with intimate needs and desires. This article examines how gay Catholics manage conflicting areas between their sexual and religious selves. Eight Polish gays with a Catholic background, who identified themselves as strong believers, shared their experiences during semi-structured interviews that were subjected to interpretative phenomenological analysis. Results showed that internalization of the principles taught by the Roman Catholic Church triggered a conflict when participants became aware of their homosexuality. They used a number of strategies to reconcile conflicting identities, including limiting their religious involvement, questioning interpretation of the doctrine, undermining priests' authority, trying to reject homosexual attraction, putting trust in God's plan, using professional help, and seeking acceptance from clergy. This study alerts mental health professionals to specific risk factors associated with experiencing a religious conflict, and offers guidelines for counseling and further research. PMID:27220312

  4. Toward a Mechanistic Understanding of Environmentally Forced Zoonotic Disease Emergence: Sin Nombre Hantavirus

    PubMed Central

    Carver, Scott; Mills, James N.; Parmenter, Cheryl A.; Parmenter, Robert R.; Richardson, Kyle S.; Harris, Rachel L.; Douglass, Richard J.; Kuenzi, Amy J.; Luis, Angela D.

    2015-01-01

    Understanding the environmental drivers of zoonotic reservoir and human interactions is crucial to understanding disease risk, but these drivers are poorly predicted. We propose a mechanistic understanding of human–reservoir interactions, using hantavirus pulmonary syndrome as a case study. Crucial processes underpinning the disease's incidence remain poorly studied, including the connectivity among natural and peridomestic deer mouse host activity, virus transmission, and human exposure. We found that disease cases were greatest in arid states and declined exponentially with increasing precipitation. Within arid environments, relatively rare climatic conditions (e.g., El Niño) are associated with increased rainfall and reservoir abundance, producing more frequent virus transmission and host dispersal. We suggest that deer mice increase their occupancy of peridomestic structures during spring–summer, amplifying intraspecific transmission and human infection risk. Disease incidence in arid states may increase with predicted climatic changes. Mechanistic approaches incorporating reservoir behavior, reservoir–human interactions, and pathogen spillover could enhance our understanding of global hantavirus ecology, with applications to other directly transmitted zoonoses. PMID:26955081

  5. The color of sin: white and black are perceptual symbols of moral purity and pollution.

    PubMed

    Sherman, Gary D; Clore, Gerald L

    2009-08-01

    Three studies examined automatic associations between words with moral and immoral meanings and the colors black and white. The speed of color naming in a Stroop task was faster when words in black concerned immorality (e.g., greed), rather than morality, and when words in white concerned morality (e.g., honesty), rather than immorality. In addition, priming immorality by having participants hand-copy an unethical statement speeded identification of words in the black font. Making immorality salient in this way also increased the moral Stroop effect among participants who had not previously shown it. In the final study, participants also rated consumer products. Moral meanings interfered with color naming most strongly among those participants who rated personal cleaning products as especially desirable. The moderation of the moral Stroop effect by individual differences in concerns about personal cleanliness suggests that ideas about purity and pollution are central to seeing morality in black and white.

  6. Bless me reader for I have sinned: physicians and confessional writing.

    PubMed

    Wear, Delese; Jones, Therese

    2010-01-01

    From the poetry of William Carlos Williams, the novels of Walker Percy, and the short stories of Anton Chekov to the contemporary essays of Atul Gawande, physicians' contributions to literary genres have been significant. This article explores the specific form of confessional writing offered by physicians during the past half century, writing that often exposes medical error or negative feelings towards patients. A history of confessional practices as a legal tool, as religious practice, and as literary genre is offered, followed by analyses of selected confessional writings by physicians, many of them found in clinical journals such as Journal of the American Medical Association, Annals of Internal Medicine, and the Lancet. The authors of the narratives described here are engaged in several or all elements of the confessional sequence, which may offer them some resolution through the exposure and acknowledgment of their shared humanity with their patients and their expression of regret for any harm done.

  7. The active metal brazing of TZM-Mo and SiN ceramics

    NASA Astrophysics Data System (ADS)

    Stephens, J. J.; Vianco, P. T.; Hosking, F. M.

    1996-01-01

    The active metal brazing of ceramics holds the opportunity to design metal-ceramic brazing processes without conventional metallization and nickel-plating steps. Because of their intermediate thermal coefficient of expansion (TCE) properties, molybdenum and the TZM-Mo alloy (Mo-0.5Ti-0.08Zr) are attractive candidates for joining to silicon- nitride ceramics. The recently developed Fe-Ni-Co-based Thermo-Span™ alloy, with reduced TCE from room temperature up to ≈400°C, is also an attractive candidate material for 700°C joint service applications. This article discusses the wetting, solid-state aging, and mechanical behavior of unalloyed molybdenum, TZM-Moalloy, Thermo-Span alloy, and silicon-nitride ceramic brazes made with three different active-metal braze alloys.

  8. Plagiarism in Speeches by College Presidents Called "Capital Offense" and "Ultimate Sin."

    ERIC Educational Resources Information Center

    Blum, Debra E.

    1988-01-01

    The issue of giving proper attribution in speeches--a problem that cost Joseph Biden his presidential candidacy--flared up in academe this year. Richard J. Sauer withdrew his candidacy for the presidency of North Dakota State University amid allegations that he plagiarized part of a speech he had delivered. (MLW)

  9. Design and characterization of integrated components for SiN photonic quantum circuits.

    PubMed

    Poot, Menno; Schuck, Carsten; Ma, Xiao-Song; Guo, Xiang; Tang, Hong X

    2016-04-01

    The design, fabrication, and detailed calibration of essential building blocks towards fully integrated linear-optics quantum computation are discussed. Photonic devices are made from silicon nitride rib waveguides, where measurements on ring resonators show small propagation losses. Directional couplers are designed to be insensitive to fabrication variations. Their offset and coupling lengths are measured, as well as the phase difference between the transmitted and reflected light. With careful calibrations, the insertion loss of the directional couplers is found to be small. Finally, an integrated controlled-NOT circuit is characterized by measuring the transmission through different combinations of inputs and outputs. The gate fidelity for the CNOT operation with this circuit is estimated to be 99.81% after post selection. This high fidelity is due to our robust design, good fabrication reproducibility, and extensive characterizations. PMID:27136982

  10. Tratamiento del cáncer sin daño al corazón

    Cancer.gov

    Investigadores de los campos de oncología y de cardiología están trabajando para encontrar formas de impedir, manejar y posiblemente aun revertir los efectos secundarios cardiovasculares de ciertas terapias del cáncer.

  11. Binning is sinning: morphological light-curve distortions due to finite integration time

    NASA Astrophysics Data System (ADS)

    Kipping, David M.

    2010-11-01

    We explore how finite integration times or equivalently temporal binning induces morphological distortions to the transit light curve. These distortions, if uncorrected for, lead to the retrieval of erroneous system parameters and may even lead to some planetary candidates being rejected as ostensibly unphysical. We provide analytic expressions for estimating the disturbance to the various light-curve parameters as a function of the integration time. These effects are particularly crucial in light of the long-cadence photometry often used for discovering new exoplanets by, for example, Convection Rotation and Planetary Transits (CoRoT) and the Kepler Missions (8.5 and 30min). One of the dominant effects of long integration times is a systematic underestimation of the light-curve-derived stellar density, which has significant ramifications for transit surveys. We present a discussion of numerical integration techniques to compensate for the effects and produce expressions to quickly estimate the errors of such methods, as a function of integration time and numerical resolution. This allows for an economic choice of resolution before attempting fits of long-cadence light-curves. We provide a comparison of the short- and long-cadence light curves of TrES-2b and show that the retrieved transit parameters are consistent using the techniques discussed here.

  12. Sins of Omission and Commission: The Press and Pre-Election Polls.

    ERIC Educational Resources Information Center

    Speckman, Karon Reinboth

    Noting that public opinion polls are here to stay, this report focuses on the difficulties of good poll reporting in newspapers that use (1) syndicated polls; (2) private polls from political candidates, or (3) their own polls, and argues that newspapers must learn how to report them well. The first section of the report traces the history of…

  13. Sins of Omission and Commission: History in English Schools and Struggles for Change.

    ERIC Educational Resources Information Center

    Sherwood, Marika

    1998-01-01

    One source of black people's alienation from English society is the attitudes perpetrated through schools and curricula. A review of history textbooks, teachers' attitudes, teacher education, academic associations, and the government shows a history of not acknowledging the role of black people in English history. (MAK)

  14. A Highly Sensitive Refractometric Sensor Based on Cascaded SiN Microring Resonators

    PubMed Central

    Zamora, Vanessa; Lützow, Peter; Weiland, Martin; Pergande, Daniel

    2013-01-01

    We investigate a highly sensitive optical sensor based on two cascaded microring resonators exploiting the Vernier effect. The architecture consists of two microrings with a slight difference in their free spectral ranges. This allows the generation of the Vernier effect for achieving ultra-high sensitivities. The sensor chip was fabricated using a silicon nitride platform and characterized with isopropanol/ethanol mixtures. A sensitivity of 0.95 nm/% was found for isopropanol concentrations in ethanol ranging from 0% to 10%. Furthermore, a collection of measurements was carried out using aqueous sodium chloride (NaCl) in solutions of different concentrations, confirming a high sensitivity of 10.3 nm/% and a bulk refractive index sensitivity of 6,317 nm/RIU. A limit of detection of 3.16 × 10−6 RIU was determined. These preliminary results show the potential features of cascaded silicon nitride microring resonators for real-time and free-label monitoring of biomolecules for a broad range of applications. PMID:24169543

  15. A highly sensitive refractometric sensor based on cascaded SiN microring resonators.

    PubMed

    Zamora, Vanessa; Lützow, Peter; Weiland, Martin; Pergande, Daniel

    2013-01-01

    We investigate a highly sensitive optical sensor based on two cascaded microring resonators exploiting the Vernier effect. The architecture consists of two microrings with a slight difference in their free spectral ranges. This allows the generation of the Vernier effect for achieving ultra-high sensitivities. The sensor chip was fabricated using a silicon nitride platform and characterized with isopropanol/ethanol mixtures. A sensitivity of 0.95 nm/% was found for isopropanol concentrations in ethanol ranging from 0% to 10%. Furthermore, a collection of measurements was carried out using aqueous sodium chloride (NaCl) in solutions of different concentrations, confirming a high sensitivity of 10.3 nm/% and a bulk refractive index sensitivity of 6,317 nm/RIU. A limit of detection of 3.16 × 10(-6) RIU was determined. These preliminary results show the potential features of cascaded silicon nitride microring resonators for real-time and free-label monitoring of biomolecules for a broad range of applications.

  16. Taxing Sin and Saving Lives: Can Alcohol Taxation Reduce Female Homicides?

    PubMed Central

    Durrance, Christine Piette; Golden, Shelley; Perreira, Krista; Cook, Philip

    2013-01-01

    With costs exceeding $5.8 billion per year, violence against women has significant ramifications for victims, their families, the health care systems that treat them, and the employers who depend on their labor. Prior research has found that alcohol abuse contributes to violence against both men and women, and that stringent alcohol control policies can reduce alcohol consumption and in turn some forms of violence. In this paper, we estimate the direct relationship between an important alcohol control measure, excise taxes, and the most extreme form of violence, homicide. We use female homicide rates as our measure of severe violence, as this measure is consistently and accurately reported across multiple years. Our results provide evidence that increased alcohol taxes reduce alcohol consumption and that reductions in alcohol consumption can reduce femicide. Unfortunately, a direct test of the relationship does not have the power to determine whether alcohol taxes effectively reduce female homicide rates. We conclude that while alcohol taxes have been shown to effectively reduce other forms of violence against women, policy makers may need alternative policy levers to reduce the most severe form of violence against women. PMID:21664738

  17. [Semantic verbal fluency of animals in amnesia-type mild cognitive impairment].

    PubMed

    Lopez-Higes, Ramón; Prados, José M; del Rio, David; Galindo-Fuentes, Marta; Reinoso, Ana Isabel; Lozano-Ibanez, Montserrat

    2014-06-01

    Introduccion y objetivo. El analisis cuantitativo y cualitativo de la tarea de fluidez verbal semantica ha permitido observar que las personas con demencia producen menos palabras y en grupos mas pequeños que las personas sin demencia. Sin embargo, en personas con deterioro cognitivo leve de tipo amnesico (DCLa) la investigacion ha mostrado resultados contradictorios respecto a la cantidad y el numero de los agrupamientos semanticos que se realizan. El objetivo de este estudio consistio en aportar nuevos datos para intentar solventar dicha controversia. Sujetos y metodos. Participaron en el estudio 22 personas mayores con diagnostico de DCLa (8 varones y 14 mujeres) y 43 adultos mayores (7 varones y 36 mujeres) con funcionamiento cognitivo normal que sirvieron de grupo control. Todos fueron evaluados en el Centro de Prevencion del Deterioro Cognitivo del Ayuntamiento de Madrid, tras completar la prueba de fluidez verbal de animales ademas de otras pruebas neuropsicologicas. Resultados. Como se esperaba, la produccion de animales fue menor en el grupo DCLa que en el grupo control, pero no se observaron diferencias ni en el tamaño medio de las agrupaciones semanticas ni en el numero de cambios entre dichas agrupaciones. Conclusiones. Los resultados son coherentes con investigaciones previas que sugieren que en el DCLa no solo concurren deficits en la memoria episodica y la memoria operativa, sino tambien en la memoria semantica. Sin embargo, los datos no aclaran el papel de los procesos ejecutivos estrategicos, como parece suceder en la enfermedad de Alzheimer.

  18. Previniendo el Uso de Drogas entre Ninos y Adolescentes: Una Guia Basada en Investigaciones (Preventing Drug Use among Children and Adolescents: A Research-Based Guide).

    ERIC Educational Resources Information Center

    Sloboda, Zili; David, Susan L.

    This question and answer guide provides an overview of the research on the origins and pathways of drug abuse, the basic principles derived from effective drug abuse prevention research, and the application of research results to the prevention of drug use among young people. The basic principles derived from drug abuse prevention research are…

  19. Mesa redonda: Argentina en proyectos globales de investigaciones espaciales y astronómicas. Uso científico de la Antena de Espacio Profundo DSA 3

    NASA Astrophysics Data System (ADS)

    Colazo, M.

    2016-08-01

    Argentine has 10 percent of the operative time available for the DSA 3 Antenna of the European Space Agency, installed in Malargüe, Mendoza. Here we present the history of the project and the current activities for the scientific use of the antenna.

  20. Mesa redonda: Argentina en proyectos globales de investigaciones espaciales y astronómicas. Astronomía óptica en Argentina

    NASA Astrophysics Data System (ADS)

    Folatelli, G.

    2016-08-01

    This is a brief summary of the current status of observational astronomy in the optical range in Argentina, as seen by the author. This roundtable presentation aimed at setting off the discussion within the community about the issue of observational facilities and its posible solutions.

  1. Realidades Suburbanas: Latinos en el Condado de Dakota. Una Investigacion Dirigida por HACER = Suburban Realities: Latinos in Dakota County. A Study Conducted by HACER.

    ERIC Educational Resources Information Center

    HACER: Hispanic Advocacy and Community Empowerment through Research, Minneapolis, MN.

    A research project was conducted between April and December of 1998 to learn about the experiences of the sizable numbers of Latinos who live in Dakota County (Minnesota). This diverse group was studied through examining existing demographic information, conducting interviews with 45 Latino and Anglo individuals, and conducting several focus…

  2. El recreo en la escuela primaria: Que indica la investigacion? (Recess in Elementary School: What Does the Research Say?) ERIC Digest.

    ERIC Educational Resources Information Center

    Jarrett, Olga S.

    Compared to the rest of the school day, recess is a time when children have more freedom to choose what they want to do and with whom. In light of the current climate of school accountability, this Spanish-language Digest discusses research on recess and its relationship to learning, social development, and child health, as well as research on…

  3. Un Modelo Basico de Instruccion Directa Para la Ensenanza de la Metodologia de la Investigacion (Using the Basic Direct Model of Instruction To Teach an Introductory Research Model).

    ERIC Educational Resources Information Center

    Serafin, Ana Gil

    This study examined the application of the Basic Direct Instruction Model (BDIM), a methodology designed to maximize student interest in instrumental and methodological courses, to graduate level educational leadership students. The research used qualitative techniques and a participatory approach with a sample of 92 beginning level Masters…

  4. Investigacion Educativa: Areas - Politicas - Estrategias y Proyectos del ICOLPE, 2 (Educational Research: Topics, Policies, Strategies, and Projects of the Colombian Institute of Pedagogy, 2),

    ERIC Educational Resources Information Center

    Ministerio de Educacion Nacional, Bogota (Colombia). Instituto Colombiano de Pedagogia.

    This booklet defines and establishes guidelines for educational research in Colombia. Sections describe basic philosophy and objectives, types of research, policies for educational investigation, governmental role, and principle areas for educational research. A listing of current and proposed research projects is provided. The final section…

  5. NCI en el congreso de ASCO: Breve reseña de los resultados de investigaciones de cánceres en mujeres

    Cancer.gov

    En el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO) 2014 celebrado en junio en Chicago, se destacaron los resultados de varios estudios clínicos patrocinados por el NCI sobre cánceres en la mujer.

  6. La investigacion sobre la calidad de los programas para ninos de hasta dos anos de edad (Research on Quality in Infant-Toddler Programs). ERIC Digest.

    ERIC Educational Resources Information Center

    Honig, Alice Sterling

    Concern about the quality of infant-toddler care programs has grown recently in response to two factors. The first is the need of employed parents for such care, and the second is research emphasizing the importance of brain development in the early years. This Spanish-language Digest introduces some of the many issues related to the quality of…

  7. Metodo y Proceso de la Investigacion Participativa en la Capacitacion Rural (The Method and Process of Participatory Research in Rural Leadership Training). Cuadernos del CREFAL 19.

    ERIC Educational Resources Information Center

    de Schutter, Anton

    In participatory research, education and learner participation are directly connected. The document analyzes the role of a participatory research method in the basic education of rural adults. The different phases of the Participant Research method are presented, along with a profound analysis of both research and participation. The claim is that…

  8. Consideraciones sobre la investigacion hermeneutica en la educacion en lenguas y culturas extranjeras (Aspects of Applying a Hermeneutic Approach to Foreign Language and Culture Education).

    ERIC Educational Resources Information Center

    Zoreda, Margaret Lee

    Drawing on writings by recent post-modernist thinkers and semioticians, this paper focuses on a combination of hermeneutic and semiotic viewpoints and applies them to defining the nature of interpretation in an educational setting (e.g., text interpretation), the interpreter, and the essence of the act of comprehension and interpretation. The main…

  9. Indice Bibliografico de Investigaciones Pedagogicas 1948-1968. Estudio y Tesis. Volumen I. (Bibliographic Index of Pedagogical Research, 1948-1968. Studies and Theses. Volume I.)

    ERIC Educational Resources Information Center

    Puerto Rico Univ., Rio Piedras.

    This bibliography presents a comprehensive index of research from 1948 to 1968 on topics relating to Puerto Ricans and education. Included are studies from Puerto Rican, U.S. and European universities and research centers. The bibliography, which is divided into three separate books, is organized by subject: Part 1 cites literature on:…

  10. Off-label and unlicensed utilization of drugs in a Brazilian pediatric hospital.

    PubMed

    Pereira Gomes, Vanessa; Melo da Silva, Kédma; Oliveira Chagas, Suely; dos Santos Magalhães, Igor Rafael

    2015-05-01

    Objetivo: Describir los patrones de utilizacion de medicamentos off-label y sin licencia en un hospital pediatrico de Brasil. Métodos: La investigacion consistio en un estudio descriptivo, prospectivo y de corte transversal. Resultados: Un total de 1.158 medicamentos fueron prescritos para 320 pacientes, que representan 65 farmacos diferentes. En cuanto a la clasificacion de la utilizacion de medicamentos, la mayoria de los medicamentos fueron prescritos como en la ficha tecnica (57,2%), seguido off-label (36,4%) y por sin licencia (6,3%). Las prevalencias de uso sin licencia y off-label de drogas en la poblacion estudiada fueron 20,9 y 77,8%, respectivamente. La polifarmacia fue muy asociada a ambos off-label y el regimen sin licencia (OR 12,9; IC del 95%: 3,07 a 54,2 y OR 3,68; IC del 95%: 2,02 a 6,69, respectivamente), mientras que los ninos en edad preescolar fueron menos propensos a prescripcion sin licencia (OR 0,39; 95% CI 0,19-,79). El sexo y la duracion de la hospitalizacion no estaban relacionadas con estos resultados. Conclusiones: Son necesarios mas estudios para verificar el impacto de este patron en la ocurrencia de eventos adversos en los medicamentos.

  11. [Neurological complications of tick-borne relapsing fever].

    PubMed

    Castilla-Guerra, L; Fernandez-Moreno, M C; Vergara-Lopez, S; Merino-Rumin, M; Colmenero-Camacho, M A

    2016-09-16

    Introduccion. La fiebre recurrente transmitida por garrapatas (FRTG) puede producir complicaciones neurologicas. No existen apenas estudios en España sobre el tema. Objetivo. Estudiar la prevalencia y las caracteristicas clinicas de las complicaciones neurologicas de los pacientes con FRTG. Pacientes y metodos. Estudio retrospectivo de los pacientes atendidos con FRTG durante 12 años (2004-2015) en un hospital de una zona rural del sur de España. Resultados. Se incluyeron 75 pacientes, 42 varones (56%), con una edad media de 33 años (rango: 14-72 años). Se observaron picaduras de garrapatas en nueve pacientes (12%). Los sintomas mas frecuentes fueron: fiebre en 64 pacientes (85,3%), cefalea en 41 (54,6%) y vomitos en 26 (34,6%). Se sospecho afectacion meningea en nueve pacientes (12%), de los que tres (4%) tenian signos meningeos en el momento del ingreso. A todos ellos se les realizo una puncion lumbar. Ninguno presento paralisis facial ni otra manifestacion neurologica. Se encontraron alteraciones del liquido cefalorraquideo en los tres pacientes con meningismo. En uno de los casos se visualizo Borrelia en el liquido cefalorraquideo. En los pacientes con afectacion neurologica, el tratamiento utilizado fue penicilina G en un caso y ceftriaxona en dos. Todos los pacientes se recuperaron completamente. Conclusiones. La FRTG es una de las formas menos graves de borreliosis, y menos del 5% de los pacientes presenta complicaciones neurologicas. Sin embargo, los medicos deben saber que Borrelia puede causar meningitis en los sujetos expuestos a garrapatas en regiones endemicas de FRTG.

  12. [Complex febrile crises: should we change the way we act?].

    PubMed

    Martinez-Cayuelas, E; Herraiz-Martinez, M; Villacieros-Hernandez, L; Cean-Cabrera, L; Martinez-Salcedo, E; Alarcon-Martinez, H; Domingo-Jimenez, R; Perez-Fernandez, V

    2014-11-16

    Introduccion. Las convulsiones febriles son una de las causas mas frecuentes de consulta. Hasta ahora, los pacientes con convulsiones febriles complejas (CFC) deben ingresar, dado el mayor porcentaje de epilepsia y complicaciones agudas descrito clasicamente. En la actualidad hay estudios que apoyan ser menos invasivos en el abordaje de estos pacientes. Objetivo. Describir las caracteristicas de los pacientes ingresados por CFC y proponer un nuevo protocolo de actuacion. Pacientes y metodos. Analisis retrospectivo de historias clinicas de ingresados por CFC (enero de 2010-diciembre de 2013). Se ofrecen datos epidemiologicos, clinicos, pruebas complementarias y evolucion. Resultados. Las CFC suponian un 4,2% de los ingresos de neuropediatria (n = 67). Edad media al evento: 25 meses. El 47% tenia antecedentes familiares patologicos, y el 31%, antecedentes personales de convulsion febril previa. En el 54% de los pacientes, la CFC duro menos de cinco minutos; hubo recurrencia, la mayoria con un total de dos crisis y durante el primer dia (las CFC por recurrencia son las mas frecuentes). De las pruebas complementarias realizadas, ninguna de ellas sirvio como apoyo diagnostico en el momento agudo. Durante su seguimiento, cinco pacientes presentaron complicaciones. Los pacientes con antecedentes familiares de convulsiones febriles presentan mayor riesgo de epilepsia o recurrencia (p = 0,02), sin diferencias significativas respecto a la edad, numero de crisis, intervalo de fiebre, estado epileptico o tipo de CFC. Conclusiones. Las CFC no asocian mayores complicaciones agudas; las exploraciones complementarias no permiten discriminar precozmente a los pacientes de riesgo. Su ingreso podria evitarse en ausencia de otros signos clinicos y limitarse a casos seleccionados.

  13. [Recurring post-traumatic growing skull fracture].

    PubMed

    San Martín-García, Isabel; Aguilera-Albesa, Sergio; Zazpe-Cenoz, Idoya; Yoldi-Petri, M Eugenia

    2015-04-16

    Introduccion. La fractura craneal evolutiva, tambien llamada absorcion osea postraumatica o quiste leptomeningeo, es una rara complicacion de los traumatismos craneoencefalicos y ocurre de forma casi exclusiva en ninos menores de 3 anos. Caso clinico. Nino de 6 meses que presentaba, dos meses despues de un traumatismo craneal aparentemente banal, persistencia de cefalohematoma temporooccipital izquierdo sin otros signos. El estudio de ecografia transfontanelar revelo un defecto oseo con herniacion cerebral, y la tomografia computarizada y la resonancia magnetica confirmaron, ademas, una fractura evolutiva. Se realizo reseccion del quiste encefalomeningeo, cierre dural y reparacion del defecto oseo con placas y material de lactato. Tres meses despues de la intervencion, presentaba persistencia de coleccion liquida y se confirmo recidiva de la fractura evolutiva. Tras la reintervencion, se coloco casco ortesico para evitar nuevas recidivas. Un ano despues del traumatismo, el paciente continua asintomatico. Conclusiones. Todo nino menor de 3 anos con cefalohematoma postraumatico deberia ser revisado de forma periodica hasta comprobar la resolucion de la coleccion, en particular si presenta fractura craneal. La presencia de un cefalohematoma persistente mas de dos semanas despues de un traumatismo craneoencefalico debe hacernos sospechar un proceso de fractura creciente, y son necesarias la reparacion de la duramadre y una craneoplastia para su tratamiento. La colocacion de material reabsorbible permite su remodelacion con el crecimiento craneal del paciente, pero su fragilidad conlleva riesgo de recidiva. La colocacion de un casco ortesico tras la intervencion podria prevenir complicaciones.

  14. [Signaling pathways mTOR and AKT in epilepsy].

    PubMed

    Romero-Leguizamon, C R; Ramirez-Latorre, J A; Mora-Munoz, L; Guerrero-Naranjo, A

    2016-07-01

    Introduccion. La via de señalizacion AKT/mTOR es un eje central en la regulacion celular, especialmente en las enfermedades neurologicas. En la epilepsia, se ha evidenciado su alteracion dentro de su proceso fisiopatologico. Sin embargo, aun no se han descrito todos los mecanismos de estas rutas de señalizacion, las cuales podrian abrir la puerta hacia nuevas investigaciones y estrategias terapeuticas, que finalmente permitan desarrollar tratamientos efectivos en enfermedades neurologicas como la epilepsia. Objetivo. Revisar las asociaciones existentes entre las rutas de señalizacion intracelular de mTOR y AKT en la fisiopatologia de la epilepsia. Desarrollo. La epilepsia es una enfermedad neurologica con un alto impacto epidemiologico en el mundo, por lo cual es de sumo interes la investigacion de los componentes fisiopatologicos que puedan generar nuevos tratamientos farmacologicos. En esta busqueda se han involucrado diferentes rutas de señalizacion intracelular en neuronas, como determinantes epileptogenos. Los avances en esta materia han permitido incluso la implementacion de nuevas estrategias terapeuticas exitosas y que abren el camino hacia nuevas investigaciones. Conclusiones. Mejorar los conocimientos respecto al papel fisiopatologico de la via de señalizacion mTOR/AKT en la epilepsia permite plantear nuevas investigaciones que ofrezcan nuevas alternativas terapeuticas para el tratamiento de la enfermedad. El uso de inhibidores de mTOR ha surgido en los ultimos años como una alternativa eficaz en el tratamiento de algunos tipos de epilepsias, pero es evidente la necesidad de seguir en la busqueda de nuevas terapias farmacologicas involucradas en estas vias de señalizacion.

  15. Creciendo Sin Drogas: Guia de Prevencion para Padres (Growing Up Drug-Free: A Parent's Guide to Prevention).

    ERIC Educational Resources Information Center

    Office of Elementary and Secondary Education (ED), Washington, DC. Safe and Drug Free Schools Program.

    This publication is part of the Department of Education's ongoing effort to provide information to emerging populations in their native language on how to create and maintain drug-free and safe schools across the nation. Throughout the publication are personal stories and artwork of elementary and secondary school students that promote the message…

  16. Sins of the Father: Revisiting Best Practices of Public Relations and Crisis Management through Case Study Analysis

    ERIC Educational Resources Information Center

    Hancox, Melissa K. Gibson; Allen, Jennifer R.

    2007-01-01

    This article examines a 2004 crisis event that occurred when the president of a small private Catholic college was accused of sexually molesting boys earlier in his career. It discusses the crisis response of college officials with the institution's various publics, including students, faculty, alumni, and the media. Our purpose is twofold. First,…

  17. Kinetics of permeation and metabolism of alpha-tocopherol and alpha-tocopheryl acetate in micro-Yucatan pig sin.

    PubMed

    Rangarajan, M; Zatz, J L

    2001-01-01

    The objective of this research was to investigate the permeation and metabolism of alpha-tocopheryl acetate (alpha-TAc) and alpha-tocopherol (alpha-T) from solution and emulsion formulations and to delineate the kinetics of such metabolism. Simple formulations containing alpha-TAc and alpha-T were applied to fresh, viable micro-Yucatan skin dermatomed to a thickness of 250-300 microns, as a finite dose in a flow-through diffusion system. The experiments were stopped at time intervals of 2, 6, 12, and 24 hours. At the end of each time interval, the amounts removed by washing, retained in the stratum corneum (SC), and penetrated into the viable skin and receptor were determined by a validated HPLC method. Receptor concentrations were below the limit of detection. alpha-TAc underwent metabolism in pig skin to the active antioxidant alpha-T. The metabolite appeared as early as two hours after application. The extent of metabolism was highest at 6-12 hours after application. No metabolism was detected in the stratum corneum. Delivery of alpha-T from isopropyl myristate (IPM) solution was more efficient than utilization of alpha-TAc from the same solution. Approximately 1.5% of alpha-T yielded the same viable skin concentration as 5% alpha-TAc. Topical application of alpha-tocopherol or its prodrug acetate was capable of enhancing the overall antioxidant capacity of pig skin. The hydrolytic pathway of alpha-TAc leading to the active antioxidant alpha-T could possibly be saturable.

  18. Thermal stability and in situ SiN passivation of InAlN/GaN high electron mobility heterostructures

    NASA Astrophysics Data System (ADS)

    Lugani, L.; Carlin, J.-F.; Py, M. A.; Grandjean, N.

    2014-09-01

    We investigate the thermal stability of nearly lattice-matched InAlN layers under metal organic vapor phase epitaxy conditions for temperatures >800 °C and show that they are not fully stable. In particular, InAlN top layers undergo degradation during high temperature annealing due to a surface related process, which causes the loss of crystal quality. This strongly impacts the transport properties of InAlN/GaN HEMT heterostructures; in particular, the mobility is significantly reduced. However, we demonstrate that high thermal stability can be achieved by capping with a GaN layer as thin as 0.5 nm. Those findings enabled us to realize in situ passivated HEMT heterostructures with state of the art transport properties.

  19. 'But one must not legalize the mentioned sin': Phenomenological vs. dynamical treatments of rods and clocks in Einstein's thought

    NASA Astrophysics Data System (ADS)

    Giovanelli, Marco

    2014-11-01

    This paper offers a historical overview of Einstein's vacillating attitude towards 'phenomenological' and 'dynamical' treatments of rods and clocks in relativity theory. In Einstein's view, a realistic microscopic model of rods and clocks was needed to account for the very existence of measuring devices of identical construction that always measure the same unit of time and the same unit of length. It will be shown that the empirical meaningfulness of both relativity theories depends on what, following Max Born, one might call the 'principle of the physical identity of the units of measure'. In an attempt to justify the validity of such a principle, Einstein was forced by different interlocutors, in particular Hermann Weyl and Wolfgang Pauli, to deal with the genuine epistemological, rather than the physical question of whether a theory should be required to describe the material devices needed for its own verification.

  20. Integration and characterization of SiN nanopores for single-molecule detection in liquid-core ARROW waveguides

    NASA Astrophysics Data System (ADS)

    Rudenko, M. I.; Yin, D.; Holmes, M.; Hawkins, A. R.; Schmidt, H.

    2007-02-01

    We demonstrate a method for integrating silicon nitride nanopores in liquid core Anti Resonant Reflecting Optical Waveguides (ARROW) for single molecule electrical detection and control. We use a two-step integration process when a micropore is fabricated first, paving the way for subsequent nanopore integration in the first silicon nitride layer of the ARROW structure. Nanopores with dimensions as small as 11 nm were fabricated using a Focused Ion Beam shrinking process commensurate with single particle gating of viruses, proteins, ribosomes and other biomolecules.

  1. Pruebas sin beneficio comprobado se usan aún para viiglar cáncer de ovario

    Cancer.gov

    Artículo del blog Temas y Relatos del NCI sobre un estudio que indica que los medicos clínicos siguen usando análisis de CA-125 y exploraciones con TC para vigilar de rutina las recurrencias aunque no se ha comprobado el beneficio de estas pruebas.

  2. Is success a sin? A conversation with the reverend Peter J. Gomes. Interview by David A. Light.

    PubMed

    Gomes, P J

    2001-09-01

    The difficult task of achieving worldly success while also storing up spiritual treasure is perennially with us, in good times and in bad. Today, however, as the economy has cooled and companies have demonstrated their mortality, questions about meaning and value appear more relevant, even urgent. HBR associate editor David A. Light recently spoke with the Reverend Peter J. Gomes, one of the nation's best-known preachers and the minister at Harvard University's Memorial Church, about why and how it is both possible and necessary to reconcile a life of success with a life of faith. To do so, says Gomes, you must first "get used to it"--come to terms with the age-old tension between being rich in spirit and rich in worldly goods. Second, you should "get over it"--arrive at an understanding of the value and responsibilities associated with power and wealth. Finally, "get on with it"--figure out how you can live your life spiritually while continuing to lead in the business world. For those wondering how to get on with spiritual development, Gomes cites the growing phenomenon of senior executives gathering with peers--out of shared need, not shared accomplishment--to pray, study sacred texts, and share their religious life together. He counsels that it's never too late to get on with it: We can amend life at any time, whether we're 35, 45, or 75. Gomes concludes that business will continue to be one of the most significant forces in American culture, but it will always struggle against people's need for a perspective that is beyond this world's.

  3. Low-cycle Fatigue and Dynamic Fracture in Gold Thin Films on SiN Supported Membranes

    NASA Technical Reports Server (NTRS)

    Hays, C. C.; Newell, J. M.; MacNeal, P. D.; Ruiz, R. P.; Holmes, W. A.; Yun, M.; Mulder, J. L.; Koch, T. C.; Bock, J. J.; Lange, A. E.

    2005-01-01

    This slide presentation focuses on the dynamic mechanical response and fatigue behavior in sub-micron thick Au-films deposited onto amorphous Si(sub X)N(sub y) substrates, with spider-web geometry, that were subjected to forced vibration (3-axis random vibration with 2 kHz roll-off frequency). The work is to advance cyrogenic detectors that can operate at 100mK, that is required to create cryogenic detectors that are to search for present day signatures of the big bang.

  4. THE SINS SURVEY OF z {approx} 2 GALAXY KINEMATICS: PROPERTIES OF THE GIANT STAR-FORMING CLUMPS

    SciTech Connect

    Genzel, R.; Foerster Schreiber, N. M.; Genel, S.; Tacconi, L. J.; Buschkamp, P.; Davies, R.; Eisenhauer, F.; Kurk, J.; Newman, S.; Jones, T.; Shapiro, K.; Lilly, S. J.; Carollo, C. M.; Renzini, A.; Bouche, N.; Burkert, A.; Cresci, G.; Ceverino, D.; Dekel, A.; Hicks, E.

    2011-06-01

    We have studied the properties of giant star-forming clumps in five z {approx} 2 star-forming disks with deep SINFONI AO spectroscopy at the ESO VLT. The clumps reside in disk regions where the Toomre Q-parameter is below unity, consistent with their being bound and having formed from gravitational instability. Broad H{alpha}/[N II] line wings demonstrate that the clumps are launching sites of powerful outflows. The inferred outflow rates are comparable to or exceed the star formation rates, in one case by a factor of eight. Typical clumps may lose a fraction of their original gas by feedback in a few hundred million years, allowing them to migrate into the center. The most active clumps may lose much of their mass and disrupt in the disk. The clumps leave a modest imprint on the gas kinematics. Velocity gradients across the clumps are 10-40 km s{sup -1} kpc{sup -1}, similar to the galactic rotation gradients. Given beam smearing and clump sizes, these gradients may be consistent with significant rotational support in typical clumps. Extreme clumps may not be rotationally supported; either they are not virialized or they are predominantly pressure supported. The velocity dispersion is spatially rather constant and increases only weakly with star formation surface density. The large velocity dispersions may be driven by the release of gravitational energy, either at the outer disk/accreting streams interface, and/or by the clump migration within the disk. Spatial variations in the inferred gas phase oxygen abundance are broadly consistent with inside-out growing disks, and/or with inward migration of the clumps.

  5. MOST Detects SPBe Pulsations in HD 127756 and HD 217543: Asteroseismic Rotation Rates Independent of v sin i

    NASA Astrophysics Data System (ADS)

    Cameron, C.; Saio, H.; Kuschnig, R.; Walker, G. A. H.; Matthews, J. M.; Guenther, D. B.; Moffat, A. F. J.; Rucinski, S. M.; Sasselov, D.; Weiss, W. W.

    2008-09-01

    The MOST (Microvariability and Oscillations of Stars ) satellite has discovered SPBe (slowly pulsating Be) oscillations in the stars HD 127756 (B1/B2 Vne) and HD 217543 (B3 Vpe). For HD 127756, 30 significant frequencies are identified from 31 days of nearly continuous photometry; for HD 217543, up to 40 significant frequencies from 26 days of data. In both cases, the oscillations fall into three distinct frequency ranges, consistent with models of the stars. The variations are caused by nonradial g-modes (and possibly r-modes) distorted by rapid rotation and excited by the opacity mechanism near the iron opacity bump. A comparison of pulsation models and observed frequency groups yields a rotation frequency for each star, independently of vsin i. The rotation rates of these stars, as well as those of the SPBe stars previously discovered by MOST, HD 163868 and β CMi, are all close to their critical values. Based on data from the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon, Inc., the University of Toronto Institute of Aerospace Studies, and the University of British Columbia with the assistance of the University of Vienna.

  6. Broad-band efficiency calibration of ITER bolometer prototypes using Pt absorbers on SiN membranes.

    PubMed

    Meister, H; Willmeroth, M; Zhang, D; Gottwald, A; Krumrey, M; Scholze, F

    2013-12-01

    The energy resolved efficiency of two bolometer detector prototypes for ITER with 4 channels each and absorber thicknesses of 4.5 μm and 12.5 μm, respectively, has been calibrated in a broad spectral range from 1.46 eV up to 25 keV. The calibration in the energy range above 3 eV was performed against previously calibrated silicon photodiodes using monochromatized synchrotron radiation provided by five different beamlines of Physikalische Technische Bundesanstalt at the electron storage rings BESSY II and Metrology Light Source in Berlin. For the measurements in the visible range, a setup was realised using monochromatized halogen lamp radiation and a calibrated laser power meter as reference. The measurements clearly demonstrate that the efficiency of the bolometer prototype detectors in the range from 50 eV up to ≈6 keV is close to unity; at a photon energy of 20 keV the bolometer with the thick absorber detects 80% of the photons, the one with the thin absorber about 50%. This indicates that the detectors will be well capable of measuring the plasma radiation expected from the standard ITER scenario. However, a minimum absorber thickness will be required for the high temperatures in the central plasma. At 11.56 keV, the sharp Pt-L3 absorption edge allowed to cross-check the absorber thickness by fitting the measured efficiency to the theoretically expected absorption of X-rays in a homogeneous Pt-layer. Furthermore, below 50 eV the efficiency first follows the losses due to reflectance expected for Pt, but below 10 eV it is reduced further by a factor of 2 for the thick absorber and a factor of 4 for the thin absorber. Most probably, the different histories in production, storage, and operation led to varying surface conditions and additional loss channels.

  7. Living with the Sins of Their Fathers: An Analysis of Self-Representation of Adolescents Born of War Rape

    ERIC Educational Resources Information Center

    Erjavec, Karmen; Volcic; Zala

    2010-01-01

    Children born of war rape continue to be a taboo theme in many post-war societies, also in Bosnia and Herzegovina (BH). This study is based on in-depth interviews with eleven adolescents born of war rape in BH. The main goal is to present how these adolescents represent themselves and their life-situations. On the basis of the research we identify…

  8. Forgive me Father for I have sinned: the role of a Christian upbringing on lesbian, gay, and bisexual identity development.

    PubMed

    Lapinski, Jessica; McKirnan, David

    2013-01-01

    This study (n = 84) examined the extent to which a Christian upbringing may inhibit same-sex attracted individuals from accepting a lesbian, gay, and bisexual (LGB) identity. No significant differences were found between current and former Christians' positive or negative gay identities. Participants who had left Christianity were more liberal and viewed God as hostile. Participants' "outness" as LGB to their primary network was associated with a greater positive and lesser negative gay identity. Participants' LGB network size was not related to either their positive or negative gay identifications. Finally, the participants' sexual histories were not related to their negative identities, but were related to their positive identities.

  9. Broad-band efficiency calibration of ITER bolometer prototypes using Pt absorbers on SiN membranes

    NASA Astrophysics Data System (ADS)

    Meister, H.; Willmeroth, M.; Zhang, D.; Gottwald, A.; Krumrey, M.; Scholze, F.

    2013-12-01

    The energy resolved efficiency of two bolometer detector prototypes for ITER with 4 channels each and absorber thicknesses of 4.5 μm and 12.5 μm, respectively, has been calibrated in a broad spectral range from 1.46 eV up to 25 keV. The calibration in the energy range above 3 eV was performed against previously calibrated silicon photodiodes using monochromatized synchrotron radiation provided by five different beamlines of Physikalische Technische Bundesanstalt at the electron storage rings BESSY II and Metrology Light Source in Berlin. For the measurements in the visible range, a setup was realised using monochromatized halogen lamp radiation and a calibrated laser power meter as reference. The measurements clearly demonstrate that the efficiency of the bolometer prototype detectors in the range from 50 eV up to ≈6 keV is close to unity; at a photon energy of 20 keV the bolometer with the thick absorber detects 80% of the photons, the one with the thin absorber about 50%. This indicates that the detectors will be well capable of measuring the plasma radiation expected from the standard ITER scenario. However, a minimum absorber thickness will be required for the high temperatures in the central plasma. At 11.56 keV, the sharp Pt-L3 absorption edge allowed to cross-check the absorber thickness by fitting the measured efficiency to the theoretically expected absorption of X-rays in a homogeneous Pt-layer. Furthermore, below 50 eV the efficiency first follows the losses due to reflectance expected for Pt, but below 10 eV it is reduced further by a factor of 2 for the thick absorber and a factor of 4 for the thin absorber. Most probably, the different histories in production, storage, and operation led to varying surface conditions and additional loss channels.

  10. Synthesis and properties of SiN coatings as stable fluorescent markers on vertically aligned carbon nanofibers

    SciTech Connect

    Pearce, Ryan; Klein, Kate L; Ivanov, Ilia N; Hensley, Dale K; Meyer III, Harry M; Melechko, Anatoli; McKnight, Timothy E

    2014-01-01

    The growth of vertically aligned carbon nanofibers (VACNFs) in a catalytic dc ammonia/acetylene plasma process on silicon substrates is often accompanied by sidewall deposition of material that contains mostly Si and N. In fluorescent microscopy experiments, imaging VACNF interfacing to live cell cultures it turned out that this material is broadly fluorescent, which made VACNFs useful as spatial markers, or created nuisance when DNA-labeling got masked. In this paper we provide insight into nature of this silicon/nitrogen in situ coatings. Here we have proposed a potential mechanism for deposition of SiNx coating on the sidewalls of VACNFs during PECVD synthesis in addition to exploring the origin of the coatings fluorescence. It seems most likely that the substrate reacts with the process gases through both processes similar to reactive sputtering and CVD to form silane and other silicon bearing compounds before being deposited isotropically as a SiNx coating onto the VACNFs. The case for the presence of Si-NCs is made strong through a combination of the strong fluorescence and elemental analysis of the samples. These broadly luminescent fibers can prove useful as registry markers in fluorescent cellular studies.

  11. [Choledocholithiasis and pregnancy. Hybrid laparo-endoscopic treatment in one step].

    PubMed

    Valadez-Caballero, David; González-Santamaría, Roberto; Soto-Mendoza, Héctor; Alberto Blanco-Figueroa, Jorge; Flores-Pantoja, Juan Manuel

    2014-01-01

    Antecedentes: las complicaciones asociadas con la coledocolitiasis son poco comunes durante el embarazo. Sin embargo, cuando aparecen incrementan la morbilidad y mortalidad para el feto y la madre. Caso clínico: paciente femenina de 25 años de edad, en el segundo trimestre de embarazo. El padecimiento actual lo inició cuatro días previos a su ingreso al hospital, con dolor abdominal en el hipocondrio derecho acompañado de náuseas y vómito. A las 24 horas se agregó ictericia y coluria. A la exploración física se encontró tinte ictérico, dolor en el hipocondrio derecho, sin irritación peritoneal. Útero a nivel de la cicatriz umbilical, sin actividad uterina. Los exámenes de laboratorio mostraron: elevación de bilirrubinas y transaminasas, sin leucocitosis; el ultrasonido reportó producto único vivo intrauterino, con frecuencia cardiaca de 128 latidos por minuto, vesícula biliar con múltiples litos en su interior, colédoco 10 mm y dilatación de vía biliar. Se realizó colecistectomía laparoscópica y colangiografía transoperatoria con colocación de guía transcística para canulación selectiva de la vía biliar. Durante la colangiografía endoscópica transoperatoria se extrajeron algunos litos. La evolución fue satisfactoria, toleró la dieta y fue fue dada de alta del hospital a las 48 horas. Conclusión: en el tratamiento de la coledocolitiasis y embarazo la combinación de laparoscopia y colangiografía endoscópica terapéutica en un solo tiempo es eficaz porque disminuye el riesgo de complicaciones asociadas con la canulación de la vía biliar.

  12. [In Process Citation].

    PubMed

    Santacruz-Cerdán, Elisa; Arcano, Karina; Arrieta Blanco, Francisco; Ortiz Flores, Andrés; Mateo Lobo, Raquel; Botella Carretero, José Ignacio; Vázquez Martínez, Clotilde; Zamarrón Cuesta, Isabel

    2016-01-01

    El uso de la nutrición parenteral domiciliaria (NPD) en pacientes que no pueden alcanzar sus requerimientos nutricionales por la vía enteral está aumentando en los últimos años, permitiendo la normalización del estilo de vida de los pacientes. Entre las patologías que más frecuentemente precisan de la NPD en España destacan la neoplasia y la isquemia mesentérica. Sin embargo, la NPD constituye uno de los pilares básicos del tratamiento de enfermedades mucho menos frecuentes como es el caso de la esclerosis peritoneal encapsulante. A continuación presentamos el caso de un paciente diagnosticado de esclerosis peritoneal encapsulante con soporte NPD de más de 7 años de NPD con un catéter central de inserción periférica (PICC) para la NPD sin complicaciones y pudiendo realizar su actividad laboral habitual. Dado lo excepcional del caso lo remitimos para su publicación. PMID:27019258

  13. [A novel neurocutaneous syndrome: Legius syndrome. A case report].

    PubMed

    Cemeli-Cano, Mercedes; Peña-Segura, José Luis; Fernando-Martínez, Ruth; Izquierdo-Álvarez, Silvia; Monge-Galindo, Lorena; López-Pisón, Javier

    2014-09-01

    Introduccion. El sindrome de Legius es un trastorno autosomico dominante resultante de la mutacion del gen SPRED1, que implica perdida de funcion de una de las proteinas implicada en la via patogenica RAS-MAPK, similar a la neurofibromina y por ello muestra similitudes clinicas con la neurofibromatosis tipo 1 (NF1), pero con menor gravedad. Estos pacientes presentan multiples manchas cafe con leche y pueden asociar efelides, rasgos dismorficos, lipomas y trastornos del aprendizaje sin relacionarse con la aparicion de neurofibromas, gliomas opticos, nodulos de Lisch o predisposicion tumoral. Caso clinico. Niño de 10 meses, sin antecedentes personales de interes, que consulta por hipotonia de extremidades, manchas cafe con leche y leve retraso psicomotor. En los antecedentes familiares destaca una hermana de la madre y el abuelo materno con manchas cafe con leche. En nuestro paciente, el estudio genetico fue negativo para NF1, pero se hallo una mutacion en el gen SPRED1, compatible con el sindrome de Legius. La madre asintomatica presenta la misma mutacion en el gen SPRED1. Conclusion. Es de destacar la importancia del diagnostico diferencial de NF1, con las numerosas complicaciones que puede conllevar, con una entidad recientemente descrita de mejor pronostico como es el sindrome de Legius.

  14. [In Process Citation].

    PubMed

    Santacruz-Cerdán, Elisa; Arcano, Karina; Arrieta Blanco, Francisco; Ortiz Flores, Andrés; Mateo Lobo, Raquel; Botella Carretero, José Ignacio; Vázquez Martínez, Clotilde; Zamarrón Cuesta, Isabel

    2016-02-16

    El uso de la nutrición parenteral domiciliaria (NPD) en pacientes que no pueden alcanzar sus requerimientos nutricionales por la vía enteral está aumentando en los últimos años, permitiendo la normalización del estilo de vida de los pacientes. Entre las patologías que más frecuentemente precisan de la NPD en España destacan la neoplasia y la isquemia mesentérica. Sin embargo, la NPD constituye uno de los pilares básicos del tratamiento de enfermedades mucho menos frecuentes como es el caso de la esclerosis peritoneal encapsulante. A continuación presentamos el caso de un paciente diagnosticado de esclerosis peritoneal encapsulante con soporte NPD de más de 7 años de NPD con un catéter central de inserción periférica (PICC) para la NPD sin complicaciones y pudiendo realizar su actividad laboral habitual. Dado lo excepcional del caso lo remitimos para su publicación.

  15. [Amyotrophyc lateral sclerosis; gastrointestinal complications in home enteral nutrition].

    PubMed

    Ramírez Puerta, R; Yuste Ossorio, E; Narbona Galdó, S; Pérez Izquierdo, N; Peñas Maldonado, L

    2013-11-01

    Objetivos: Analizar las complicaciones relacionadas con el soporte nutricional enteral en los pacientes con esclerosis lateral amiotrófica que forman parte de nuestro programa de ventilación mecánica domiciliaria, haciendo especial hincapié en las gastrointestinales. Método: Estudio retrospectivo de tipo descriptivo de enfermos que se incluyeron en nuestro Programa de Ventilación Mecánica Domiciliaria (PVMD) dirigido por médicos intensivistas, mediante la revisión sistemática de historias clínicas (procedentes de una base de datos de Microsoft Access), durante los años 2004-2011. Resultados: Entre los años 2004-2011 se siguieron 73 pacientes con diagnostico de Esclerosis lateral amiotrófica: 34 de ellos (46,6%) rechazaron el aporte nutricional a través de gastrostomía o de sonda nasogástrica, mientras que 39 (53,4%) aceptaron su colocación. De los 39 pacientes en los que se inició la NED: 20 eran mujeres mujeres (51,3%). La edad media de los pacienes fue de 60,6 + 13,4 años (IC 95% 56,4-64,8). Los diagnósticos al ingreso en el PVMD fueron: ELA, 21 casos (53,8%), y ELA con afectación bulbar, 18 (43,1%). Se alimentaron a través de GEP 34 pacientes (87,2%), con gastrostomía quirúrgica 3 (7,7%) y mediante sonda nasogástrica 3 (7,7%). La gastrostomía percutánea endoscópica se realizó tras la inclusión de los pacientes en el programa, con una media días de 222,7 + 356,6 (IC 95% 110,8-334,7). En pacientes con ELA la media fue de 271,4 + 449,5 días (IC 95% 130,3-412,1), con ELA y afectación bulbar de 126,4 + 131,3 días (IC 95% 90-172,6). El recambio de sonda fue de 7,3 + 4,8 meses (IC 95% 4-10,6). La nutrición enteral tuvo una duración media de 578,6 + 872,9 días (IC 95% 304,7-852,6). Se hallaron complicaciones en 35 pacientes (89,7%), y solamente en 4, no se encontró ninguna (10,3%). Ver tabla 2. El estreñimiento se manifestó, después del inicio de la NE, en 30 pacientes (76,9%); sin embargo, ya existía previamente en 18 de ellos

  16. Nutritional and metabolic status of breast cancer women.

    PubMed

    Bering, Tatiana; Maurício, Sílvia Fernandes; Silva, Jacqueline Braga da; Correia, Maria Isabel Toulson Davisson

    2014-09-28

    Introducción: El estado nutricional y metabolico se han relacionado con factores de riesgo del cancer, asi como la morbimortalidad del tratamiento del cancer. Por lo tanto, su evaluacion es importante para el desarrollo de estrategias para la promocion, mantenimiento y/o recuperacion del estado nutricional y la evolucion del cancer. Material y métodos: Se utilizaron varios metodos diferentes para la evaluacion nutricional en pacientes con cancer de mama sometidas a terapia adyuvante, incluyendo la valoracion subjetiva global (SGA), el indice de masa corporal (IMC), pliegue tricipital (PT), la circunferencia del brazo (CB), del espesor del musculo aductor del pulgar (TAPM), la fuerza de prension manual (FPM) y el porcentaje de masa grasa (PMG) mediante impedancia bioelectrica. Tambien se evaluo la presencia del sindrome metabolico (SM). Se evaluo la aparicion de complicaciones durante el tratamiento del cancer en comparacion con el estado nutricional. Resultados: Se siguieron a 78 mujeres con una edad media de 53,2 } 11,6 anos. La mayoria de los pacientes estaban bien nutridos (80,8 %). Excesiva PMG y los SM se encontraron en 80,8 % y 41,9 % de los pacientes, respectivamente. Hubo diferencias significativas en el IMC, PT, circunferencia de la cintura y la PMG entre los pacientes con y sin sindrome metabolico. La mayoria de los pacientes experimentaron complicaciones durante el tratamiento del cancer, pero no hubo asociacion con el estado nutricional o metabolico. Conclusión: En las mujeres con cancer de mama que reciben terapia adyuvante, la prevalencia del sindrome metabolico fue alta y, por el contrario, la desnutricion era baja. No hubo efectos a corto plazo del sindrome metabolico o la desnutricion en los resultados clinicos.

  17. [NEURODEGENERATIVE DISEASES; NUTRITIONAL ASPECTS].

    PubMed

    de Luis, Daniel A; Izaola, Olatz; de la Fuente, Beatriz; Muñoz-Calero, Paloma; Franco-Lopez, Angeles

    2015-08-01

    Introducción: las enfermedades neurodegenerativas producen alteraciones en el nivel de conciencia o en los mecanismos de la deglución que con frecuencia hacen necesario un soporte nutricional especializado. Objetivo: revisar el riesgo de desnutrición, así como su tratamiento, en pacientes con enfermedad cerebral vascular, enfermedad de Parkinson, demencia y esclerosis lateral amiotrófica. Desarrollo: las enfermedades neurológicas degenerativas son una de las principales indicaciones de soporte nutricional en nuestro país. En los procesos agudos (enfermedad vascular cerebral), el correcto manejo nutricional se relaciona con una mejor evolución y con una disminución de las complicaciones. En los procesos neurodegenerativos crónicos (esclerosis lateral amiatrófica y demencia), la malnutrición es un problema importante que empeora el pronóstico de estos pacientes siendo, necesario un correcto manejo de la disfagia y sus complicaciones, así como la utilización de diferentes etapas de soporte nutricional. Una correcta valoración nutricional de estos pacientes, así como un claro esquema de intervención nutricional, es imprescindible en el seguimiento de su enfermedad. Por último, en la enfermedad de Parkinson avanzada, el soporte nutricional, como en las enfermedades neurodegenerativas anteriores, es de vital importancia, sin olvidarnos de la carga proteica y su distribución en la dieta de estos pacientes. Las sociedades científicas internacionales (American Society for Parenteral and Enteral Nutrition ASPEN) recomiendan, con un grado de evidencia B, realizar un cribaje de malnutrición a los pacientes con enfermedades neurológicas. Conclusiones: una correcta valoración nutricional, así como un adecuado soporte nutricional deben formar parte del proceso diagnóstico y terapéutico de estas enfermedades.

  18. [Type IV paraesophageal hernia with 60% of gastric necrosis. Case report].

    PubMed

    Navarro-Tovar, Fernando; Juárez-de La Torre, Juan Carlos; Pérez-Ayala, Luis Carlos; Quintero-Cabrera, Eduardo

    2014-01-01

    Antecedentes: las hernias paraesofágicas son de baja incidencia y generalmente asintomáticas; sin embargo, cuando provocan síntomas, el riesgo de complicaciones se incrementa y se convierten en una urgencia quirúrgica. Caso clínico: mujer de 53 años de edad, con cuadro clínico de tres semanas de evolución, caracterizado por dolor abdominal, náusea y vómito ocasionales, a lo que se agregó oclusión intestinal 24 horas antes de que acudiera a consulta. En la valoración radiográfica y tomográfica se observó una hernia paraesofágica que requería laparotomía exploradora. Se encontró un defecto diafragmático paraesofágico de 9 cm, con un saco herniario de contenido del estómago, colon transverso y epiplón, con necrosis gástrica de 60% (en el fondo y el cuerpo). Se le practicó una resección gástrica no anatómica y plastia diafragmática. El periodo postoperatorio fue complicado porque se le hicieron otras dos intervenciones quirúrgicas por dehiscencia de gastrectomía y una más por esofagostomía cervical y yeyunostomía tipo Witzel. Conclusiones: se recomienda la reparación electiva en todos los sujetos asintomáticos con hernia paraesofágica, con el fin de evitar las posibles complicaciones. El método de abordaje depende de la experiencia del cirujano y de las condiciones en que se encuentre la hernia y las estructuras involucradas al momento del diagnóstico.

  19. [Update on post-stroke depression: posing new challenges in patients with a minor stroke or transient ischaemic attack].

    PubMed

    Carnes-Vendrell, A; Deus-Yela, J; Molina-Seguin, J; Pifarre-Paredero, J; Purroy, F

    2016-05-16

    Introduccion. El ictus es una de las principales causas de discapacidad en la poblacion adulta. El desarrollo de sintomas depresivos es la complicacion afectiva mas frecuente. Hasta ahora, en la mayoria de los estudios sobre depresion postictus se ha excluido a los pacientes que han sufrido un ictus minor o un ataque isquemico transitorio (AIT), si bien es un subgrupo igualmente vulnerable a esta enfermedad. Objetivo. Revisar los estudios publicados de depresion postictus para dilucidar los aspectos que ya se han demostrado ampliamente y los que necesitan mayor evidencia. Desarrollo. La depresion postictus es frecuente tanto en los pacientes con ictus establecido como en los pacientes con ictus minor o AIT. Aunque existen discrepancias en la definicion utilizada, aproximadamente uno de cada tres pacientes desarrollara esta complicacion. Se han identificado factores de riesgo de depresion postictus con un amplio respaldo cientifico (sexo femenino, antecedentes de depresion u otros trastornos psiquiatricos, gravedad del ictus y afectacion funcional) y otros sin el (calidad de vida, deterioro cognitivo y biomarcadores de neuroimagen). Las principales limitaciones metodologicas halladas son la confusion entre depresion postictus y sintomatologia depresiva, la variabilidad en las escalas de evaluacion usadas y la variabilidad en el momento temporal de la evaluacion del estado de animo. Hasta ahora son muy pocos los estudios en el ictus minor o el AIT. Conclusiones. Se necesitan nuevos estudios con mejor diseño que ayuden a establecer el riesgo de depresion postictus a diferentes tiempos tras el ictus, el ictus minor o el AIT, y establecer la importancia de los factores descritos previamente.

  20. [Care for patients with altered states of consciousness in a hospital for chronic and long-stay patients].

    PubMed

    Más-Sesé, Gemma; Sanchis-Pellicer, M José; Tormo-Micó, Esther; Vicente-Más, Josep; Vallalta-Morales, Manuel; Rueda-Gordillo, Diego; Conejo-Alba, Antonia; Berbegal-Serra, Juan; Martínez-Avilés, Pedro; Oltra-Masanet, Joan A; Femenia-Pérez, Miquel

    2015-03-16

    Introduccion. Un 30-40% de los pacientes con daño cerebral presenta alteraciones del nivel de conciencia, y algunos casos, estados alterados de conciencia: sindrome de vigilia sin respuesta (SVSR) o estado de minima conciencia (EMC). La recuperacion es variable y la supervivencia esta amenazada por multiples complicaciones. Objetivos. Presentar la metodologia de trabajo del Hospital La Pedrera (HLP) para pacientes en SVSR o EMC y analizar las caracteristicas clinicas de los pacientes atendidos, la evolucion, y la situacion funcional y cognitiva en el momento del alta. Pacientes y metodos. Estudio descriptivo prospectivo de pacientes atendidos en el HLP durante el periodo 2009-2013, con diagnostico de SVSR o EMC. Resultados. El HLP trabaja mediante el metodo gestion de caso, ofreciendo una atencion integral por un equipo multidisciplinar. Los pacientes se clasifican segun objetivos asistenciales. Los pacientes con SVSR o EMC se incluyen en el programa de cuidados integrales y adaptacion. Se atendio a 23 pacientes (86,9% varones), con una edad media de 54,9 años. Etiologia: hemorragia cerebral, 30,4%; encefalopatia anoxica, 26,6%; encefalopatia metabolica, 17,3%; y otras causas, 17,3%. El 73,9% ingreso en SVSR y el resto en EMC. Evolucion: el 43,4% mejoro su situacion cognitiva inicial y el 88,8% presentaba una situacion de dependencia total en el momento del alta. Las complicaciones mas frecuentes fueron infecciones respiratorias y urinarias (53,6%). El 65,2% de los casos fueron exitus. Conclusiones. La asistencia en SVSR o EMC es compleja y precisa cuidados multidisciplinares. Casi la mitad de los pacientes mejoro su situacion cognitiva, lo que justifica una actitud proactiva que intente mejorar la calidad de vida de los pacientes y sus familias.

  1. [Neurological complications in the population of children with leukaemia].

    PubMed

    Martínez-Cayuelas, Elena; Domingo-Jiménez, Rosario; Pascual-Gázquez, Juan F; Martínez-Salcedo, Eduardo; Alarcón-Martínez, Helena; Bermúdez-Cortés, Mar; Fuster-Soler, José L; Pérez-Fernández, Virginia

    2015-02-01

    Introduccion. La leucemia es el cancer mas frecuente en edad pediatrica. Su tasa de curacion es del 80% con quimioterapia intensiva, que mejora la supervivencia, pero que tambien aumenta la frecuencia de efectos adversos, incluyendo los neurologicos. Objetivos. Describir la frecuencia y caracteristicas de las complicaciones neurologicas (CN) en pacientes con leucemia aguda linfoide (LAL) y leucemia aguda mieloide (LAM), e identificar los factores asociados a su presencia, la tasa de morbilidad neurologica y la supervivencia. Pacientes y metodos. Estudio retrospectivo de las CN presentes durante el tratamiento y seguimiento de los pacientes con LAL y LAM entre 1997 y 2012 por la unidad de oncohematologia infantil. Variables analizadas: datos demograficos, diagnostico oncologico, tratamiento y CN. Resultados. Se incluyo un total de 157 pacientes, 145 sin infiltracion de sistema nervioso central al diagnostico y ocho con infiltracion (tasa de CN del 14 y 12%, respectivamente). Las CN mas frecuentes fueron: neuropatias (31%), alteracion del nivel de conciencia (27%), convulsiones (22%) y cefalea (12%). Un 40% de los pacientes con CN ha presentado secuelas, pero ninguno ha fallecido como consecuencia de la CN. Se han detectado mas CN en el grupo de edad menor de 6 años con LAL de alto grado, en niveles de gravedad mas altos y en pacientes que habian recibido trasplante de precursores hematopoyeticos, todas ellas con diferencias estadisticamente significativas. Conclusiones. Las complicaciones neurologicas son frecuentes en los pacientes con leucemia aguda, en especial en aquellos con estadio de riesgo alto (sobre todo si son menores de 6 años) y trasplante de precursores hematopoyeticos. La mortalidad asociada es baja.

  2. High prevalence of inactivity among young patients with type 1 diabetes in south Spain.

    PubMed

    Gutiérrez Manzanedo, José Vicente; Carral San Laureano, Florentino; García Domínguez, Gloria; Ayala Ortega, Carmen; Jiménez Carmona, Soledad; Aguilar Diosdado, Manuel

    2014-04-01

    Objetivos: Describir el nivel de actividad física habitual y analizar su asociación con el control metabólico y la presencia de complicaciones microvasculares en una cohorte de pacientes con diabetes tipo 1 (DM-1) del sur de España. Métodos: Estudio transversal observacional que incluyó ciento treinta pacientes de 33,9 ± 11,5 años de edad y una duración de la enfermedad de 16,5 ± 9,5 años que fueron reclutados consecutivamente en el Servicio de Endocrinología del Hospital Universitario Puerta del Mar (Cádiz, España). El nivel de actividad física habitual fue evaluado utilizando el “General Practice Physical Activity Questionnaire” (GPPAQ) conjuntamente con diversos parámetros clínicos, antropométricos, metabólicos y de complicaciones microvasculares. Resultados: Los pacientes con DM-1 fueron agrupados en cuatro categorías de nivel de actividad física: inactivo (n = 33; 25,3%), moderadamente inactivo (n = 31; 23,8%), moderadamente activo (n = 26; 20,0%) y activo (n = 40; 30,9%). No observamos diferencias significativas en el nivel de hemoglobina glucosilada (HbA1c) entre los diferentes grupos de actividad física analizados. Los pacientes clasificados como moderadamente activos y activos fueron con mayor probabilidad hombres, más jóvenes y con menores niveles plasmáticos de triglicéridos que los pacientes clasificados como inactivos o moderadamente inactivos, sin encontrarse diferencias en otras variables clínicas o antropométricas. Adicionalmente, los pacientes activos y moderadamente activos tenían una menor prevalencia de retinopatía diabética y de complicaciones microvasculares en general comparados con los pacientes inactivos o moderadamente inactivos. Conclusiones: La mitad de los pacientes con DM-1 evaluados fueron clasificados como inactivos y estos pacientes tenían mayor prevalencia de retinopatía diabética que los pacientes activos. No fueron documentadas diferencias en los niveles de HbA1c entre los diferentes grupos

  3. Report on the Workshop Interstellar Medium and Star Formation with ALMA: Looking to the Future. A Workshop to Honour Tom Wilson held at Consejo Superior de Investigaciones Científicas, Madrid, Spain, 16-17 June 2008

    NASA Astrophysics Data System (ADS)

    Martin-Pintado, Jesus

    2008-12-01

    In June 2008, a group of friends and colleagues of Tom Wilson gathered in Madrid to honour his scientific career in a workshop on ALMA organised by three of his PhD students. The workshop was devoted to reviewing recent progress in our understanding of the main topics of research that Tom has pursued during his career: the physics and chemistry of the interstellar medium and how stars form. Specific topics included Hii regions, molecular clouds, clumps, cores, outflows and masers in Galactic and extragalactic environments, mainly from an observational perspective.

  4. Lo que da buen resultado en casa. Resultados de la investigacion y Actividades de aprendizaje: Sentido comun y diversion para ninos y adultos (What Works at Home. Research Findings and Learning Activities: Common Sense and Fun for Adults and Children).

    ERIC Educational Resources Information Center

    Crook, Shirley, Ed.

    As part of an effort to encourage Hispanic parents to help their children in school, this home learning guide, which can also be obtained in taped versions, provides parents with learning activities with which to engage their children. Based on research findings, the activities are divided into the following categories: curriculum of the home,…

  5. Investigacion educativa. El sistema escolar en sus diferentes niveles, factores que favorecen o frenan su eficacia y medidas de superacion (Educational Research. The Educational System at Different Levels; Factors Promoting or Hindering Its Efficiency; Possible Improvements.

    ERIC Educational Resources Information Center

    Jimenez Lozano, Blanca; And Others

    This document is an English-language abstract (Approximately 1,500 words) of a study on educational research in Mexico. Chapter one discusses the importance of educational research, in terms of its role both in scientific and technical development; it should use scientific methods so that it will have solid foundations. Chapter two is a survey of…

  6. Results of investigation at the Miravalles Geothermal Field, Costa Rica: Part 1, Well logging. Resultados de las investigaciones en el campo geotermico de Miravalles, Costa Rica: Parte 1, Registros de pozos

    SciTech Connect

    Dennis, B.R.; Lawton, R.G.; Kolar, J.D.; Alvarado, A.

    1989-03-01

    The well-logging operations performed in the Miravalles Geothermal Field in Costa Rica were conducted during two separate field trips. The Phase I program provided the deployment of a suite of high-temperature borehole instruments, including the temperature/rabbit, fluid sampler, and three-arm caliper in Well PGM-3. These same tools were deployed in Well PGM-10 along with an additional survey run with a combination fluid velocity/temperature/pressure instrument used to measure thermodynamic properties under flowing well conditions. The Phase II program complemented Phase I with the suite of tools deployed in Wells PGM-5, PGM-11, and PGM-12. 4 refs., 25 figs., 1 tab.

  7. La Seccion de Investigacion sobre Educacion Medica de la Facultad de Medicina de la Universidad National Autonoma de Mexico (The Medical Education Investigation Section of the School of Medicine of UNAM).

    ERIC Educational Resources Information Center

    Campillo Sainz, Carlos; Alvarez, Tostado, Juan

    This document is an English-language abstract (approximately 1,500 words) of a survey of Mexican medical education needs for the future. To plan for these needs, SISEM of UNAM was formed with the objectives of carrying out and promoting investigations in the different areas of medical education. It also wants to distribute the information…

  8. Wet and Wild: A Multidisciplinary Marine Education Teacher Guide, Grades K-6. Unit III. Research: Innerspace Explorers = Humedo y Salvaje. Tercera Unidad. La Investigacion Cientifica: Exploradores del Espacio Interior.

    ERIC Educational Resources Information Center

    Murphy, Richard C.

    Topics and activities related to oceanographic research (innerspace exploration) are the focus of this multidisciplinary, marine education teaching guide for students in kindergarten through grade 6. The guide is divided into six sections (labeled A through F). The first five sections consist of various kinds of activities, with the appropriate…

  9. Results of investigation at the Miravalles geothermal field, Costa Rica. Resultados de las investigaciones en el campo geotermico de Miravalles, Costa Rica; Parte 2, Muestreo de fluidos pozo abajo

    SciTech Connect

    Grigsby, C.O.; Goff, F.; Trujillo, P.E. Jr.; Counce, D.A.; Dennis, B.; Kolar, J.; Corrales, R.; Instituto Costarricense de Electricidad, San Jose )

    1989-10-01

    Samples of the geothermal fluids in the Miravalles, Costa Rica, geothermal system were collected from production wellbores using downhole fluid samplers, from flowing wellheads using miniseparators, and from hot springs that discharge in the area. The reservoir fluid at Miravalles is a neutral-chloride-type water, but fumaroles and acid-sulfate springs are present within the main thermal area, and there are bicarbonate-rich hot springs that are clearly related to the neutral-chloride reservoir fluids. Dissolved gases are primarily a mixture of CO{sub 2} with air, but samples collected in the fumarolic areas also contain H{sub 2}S. Water-stable isotope analyses suggest local meteoric recharge, and the reservoir fluid shows oxygen isotopic shifts of about 2.5% due to high-temperature oxygen exchange between water and rock. Chemical geothermometer temperatures are consistent with the measured downhole temperature of 220{degrees} to 255{degrees}C. This pattern of neutral-chloride reservoir fluids with acid-sulfate springs near the source region and bicarbonate-rich chloride hot springs at the periphery of the system suggests a lateral outflow type of hydrothermal system. In addition to the geochemical evidence, temperature profiles from several of the wells show temperature reversals that are characteristic of lateral outflow plumes. We find no evidence for the underlying, higher temperature (300{degrees}C) system, which has been suggested by other investigators. 24 refs., 14 figs., 6 tabs.

  10. Actas de la 4th mesa redonda sobre investigacion en "Lenguas Extranjeras" en la Universidad Autonoma Metropolitana 1996. (Proceedings from the 4th Roundtable on Investigation in Foreign Languages in the Autonomous Metropolitan University 1996).

    ERIC Educational Resources Information Center

    Zoreda, Margaret Lee, Comp.; Diop, Mamoudou Si, Comp.; Vivaldo Lima, Javier, Comp.

    The articles included in this volume were selected as exemplary papers from the conference in Mexico. The goal of the forum was to provide an opportunity for researchers from the three branches of the Universidad Autonoma Metropolitana (UAM) to meet and discuss research projects currently in progress at the university. The works presented here…

  11. [Relationships between language disorders and socio-emotional competence].

    PubMed

    Baixauli-Fortea, Inmaculada; Roselló-Miranda, Belén; Colomer-Diago, Carla

    2015-02-25

    Introduccion. Existe una comorbilidad elevada entre los trastornos del lenguaje y los problemas conductuales, emocionales y sociales. Objetivo. Revisar la bibliografia existente sobre las dificultades sociales y emocionales de los niños con trastorno especifico del lenguaje desde una perspectiva evolutiva. Desarrollo. En la infancia temprana, los resultados acerca de este tipo de dificultades en niños con un retraso del lenguaje no son concluyentes. Sin embargo, desde el periodo de educacion infantil, la investigacion advierte de una mayor ocurrencia de alteraciones en el area social y emocional. Los estudios longitudinales que han permitido determinar el ajuste psicosocial en la adolescencia indican un mayor riesgo de presentar experiencias de victimizacion y bullying o de desarrollar ansiedad y depresion a largo plazo, aunque algunos trabajos ofrecen una panoramica mas alentadora. Conclusiones. La afectacion de la comprension y del componente pragmatico del lenguaje es un predictor importante en la manifestacion de alteraciones socioemocionales. En los trastornos mixtos comprensivos-expresivos, una dificultad de procesamiento general podria justificar, al menos parcialmente, esta asociacion. A su vez, es probable que limitaciones en el desarrollo de la cognicion social contribuyan a explicar, en cierta medida, las dificultades de las personas con trastornos pragmaticos, si bien no existe una consistencia en la investigacion en este sentido.

  12. Violencia de Pareja en Mujeres Hispanas: Implicaciones para la Investigación y la Práctica

    PubMed Central

    Gonzalez-Guarda, Rosa Maria; Becerra, Maria Mercedes

    2012-01-01

    Las investigaciones sobre la violencia entre parejas sugieren que las mujeres hispanas están siendo afectadas desproporcionadamente por la ocurrencia y consecuencias de este problema de salud pública. El objetivo del presente artículo es dar a conocer el estado del arte en relación a la epidemiologia, consecuencias y factores de riesgo para VP entre mujeres Hispanas, discutiendo las implicaciones para la investigación y la práctica. Investigaciones han demostrado una fuerte asociación del status socioeconómico, abuso de droga y el alcohol, la salud mental, aculturación, inmigración, comportamientos sexuales riesgosos e historia de abuso con la violencia entre parejas. Sin embargo, más estudios se deben llevar a cabo para identificar otros factores de riesgos y de protección a poblaciones hispanas no clínicas. Mientras que el conocimiento sobre la etiología de la VP entre mujeres Hispanas se expanda, enfermeras y otros profesionales de la salud deben desarrollar, implementar y evaluar estrategias culturalmente adecuadas para la prevención primaria y secundaria de la violencia entre pareja. PMID:26166938

  13. U.S.A./Mexico Adult Literacy Project: Educacion sin Fronteras/Education without Borders. Final Report, January 1, 1993 - September 30, 1993.

    ERIC Educational Resources Information Center

    Hacienda La Puente Unified School District, City of Industry, CA.

    A cooperative literacy education program involving Mexico and the United States' border states is documented. The project has three objectives: to (1) implement the Mexican literacy agency's approach to promoting literacy among native Spanish speakers; (2) coordinate U.S./Mexico literacy task force activities; and (3) develop an immigrants' rights…

  14. Small copper-doped silicon clusters CuSin (n = 4-10) and their anions: structures, thermochemistry, and electron affinities.

    PubMed

    Lin, Lin; Yang, Jucai

    2015-06-01

    The structures and energies of copper-doped small silicon clusters CuSi n (n = 4-10) and their anions were investigated systematically using CCSD(T)/aug-cc-pVTZ-DK//MP2/6-31G(2df,p), G4//MP2/6-31G(2df,p), and the B3LYP/6-311+G* basis set. The performance of the methods used for the prediction of energetic and thermodynamic properties was evaluated. Comparing experimental [Xu et al. (2012) J Chem Phys 136:104308] and theoretical calculations, it was concluded that the CCSD(T) results are very accurate and exhibit the best performance; the mean absolute deviation from experimental data was 0.043 eV. The excellent agreement of vertical detachment energy (VDE) between experimental results and CCSD(T) calculations indicates that the ground state structures of CuSi n (-) (n = 4-10) presented in this paper are reliable. For CuSi10, assigning 2.90±0.08 eV to the experimental adiabatic electron affinity (AEA) and 3.90±0.08 eV to the VDE is more reasonable than to 3.46±0.08 eV and 3.62±0.08 eV, respectively, based on the CCSD(T) calculations and the previous photoelectron spectrum of CuSi10 (-) (Xu et al., op. cit.). The AEAs of CuSi n (n = 4-10), excluding CuSi7, are in excellent agreement with experimental data, showing that the ground state structures of CuSi n (n = 4-6, 8-10) reported in this paper are reliable. CuSi10 is suggested to be the smallest endohedral ground state structure. However, adding an additional electron to CuSi10 pulls out the Cu atom from the center location, forming an exohedral ground state structure of CuSi10 (-). The charge transfer and dissociation energy of Cu from CuSi n and their anions determined to examine the nature of bonding and their relative stabilities. PMID:26003428

  15. Specific heat measurement of thin suspended SiN membrane from 8 K to 300 K using the 3ω-Völklein method.

    PubMed

    Ftouni, Hossein; Tainoff, Dimitri; Richard, Jacques; Lulla, Kunal; Guidi, Jean; Collin, Eddy; Bourgeois, Olivier

    2013-09-01

    We present a specific heat measurement technique adapted to thin or very thin suspended membranes from low temperature (8 K) to 300 K. The presented device allows the measurement of the heat capacity of a 70 ng silicon nitride membrane (50 or 100 nm thick), corresponding to a heat capacity of 1.4 × 10(-10) J/K at 8 K and 5.1 × 10(-8) J/K at 300 K. Measurements are performed using the 3ω method coupled to the Völklein geometry. This configuration allows the measurement of both specific heat and thermal conductivity within the same experiment. A transducer (heater/thermometer) is used to create an oscillation of the heat flux on the membrane; the voltage oscillation appearing at the third harmonic which contains the thermal information is measured using a Wheatstone bridge set-up. The heat capacity measurement is performed by measuring the variation of the 3ω voltage over a wide frequency range and by fitting the experimental data using a thermal model adapted to the heat transfer across the membrane. The experimental data are compared to a regular Debye model; the specific heat exhibits features commonly seen for glasses at low temperature.

  16. Secondary-phase orientation probed by EPR:mY2 BaCuO5sin YBa2 Cu3 O7-xs

    NASA Astrophysics Data System (ADS)

    Pellerin, N.; Simon, P.; Odier, P.; Gotor, F. J.; Poirot, N. J.; Vutien, L.; Durand, L.; Monot, I.

    1997-01-01

    Textured YBa2 Cu3 O7-x samples have been studied by electronic paramagnetic resonance.mEPR spectroscopy allows us to analyze the Y2 BaCuO5 second phase present as inclusions in the YBa2 Cu3 O6 textured matrix. All samples were deoxygenated in order to limit the skin effect due to conductivity. This is applied to samples textured according to different techniques. Preferential orientation of these particles according to the 123 matrix can be observed. For instance, if texturing under a magnetic field, the particular Y2 BaCuO5 orientation is observed of the b211 axis (b=7.132 Å) parallel to c123 and to the magnetic field direction. By appropriate calculations from initial spectra, the fraction of preferred orientation of these Y2 BaCuO5 grains can be quantified. This orientation comprises 16+/-2 % of the Y2 BaCuO5 weight for texturing under a magnetic field, presently one of the highest values obtained. It involves the longest size of Y2 BaCuO5 elongated grains lying in YBa2 Cu3 O6 planes, facilitating the texturation process. Texturing on Y2 O3 by the modified melt textured growth method leads to a preferential orientation of Y2 BaCuO5 grains too, but in another direction, i.e., b211 perpendicular to c123 . There is no Y2 BaCuO5 preferential orientation if texturing with a thermal gradient or on a monocrystalline MgO substrate. This type of analysis can be applied easily to other systems (nanocomposites, dispersoids, etc.), providing that the signal of the secondary phase can be clearly separated from the signal of the primary one.

  17. Near-Field Integration of a SiN Nanobeam and a SiO2 Microcavity for Heisenberg-Limited Displacement Sensing

    NASA Astrophysics Data System (ADS)

    Schilling, R.; Schütz, H.; Ghadimi, A. H.; Sudhir, V.; Wilson, D. J.; Kippenberg, T. J.

    2016-05-01

    Placing a nanomechanical object in the evanescent near field of a high-Q optical microcavity gives access to strong gradient forces and quantum-limited displacement readout, offering an attractive platform for both precision sensing technology and basic quantum optics research. Robustly implementing this platform is challenging, however, as it requires integrating optically smooth surfaces separated by ≲λ /10 . Here we describe an exceptionally high-cooperativity, single-chip optonanomechanical transducer based on a high-stress Si3N4 nanobeam monolithically integrated into the evanescent near field of SiO2 microdisk cavity. Employing a vertical integration technique based on planarized sacrificial layers, we realize beam-disk gaps as little as 25 nm while maintaining mechanical Q f >1012 Hz and intrinsic optical Q ˜107. The combination of low loss, small gap, and parallel-plane geometry results in radio-frequency flexural modes with vacuum optomechanical coupling rates of 100 kHz, single-photon cooperativities in excess of unity, and large zero-point frequency (displacement) noise amplitudes of 10 kHz (fm )/√ Hz . In conjunction with the high power-handling capacity of SiO2 and low extraneous substrate noise, the transducer performs particularly well as a sensor, with recent deployment in a 4-K cryostat realizing a displacement imprecision 40 dB below that at the standard quantum limit (SQL) and an imprecision-backaction product <5 ℏ [Wilson et al., Nature (London) 524, 325 (2015)]. In this report, we provide a comprehensive description of device design, fabrication, and characterization, with an emphasis on extending Heisenberg-limited readout to room temperature. Towards this end, we describe a room-temperature experiment in which a displacement imprecision 32 dB below that at the SQL and an imprecision-backaction product <60 ℏ is achieved. Our results extend the outlook for measurement-based quantum control of nanomechanical oscillators and suggest an alternative platform for functionally integrated "hybrid" quantum optomechanics.

  18. Reports from the field: engaging learners as interpreters for developing health messages -- designing the 'Familias Sin Plomo' English as a Second Language curriculum project.

    PubMed

    Handley, Margaret A; Santos, Maricel G; McClelland, Jeff

    2009-09-01

    California has a recently documented problem of trans-national environmental lead exposures in imported foods from Mexico but there is limited health information available in immigrant communities about this problem. This report highlights collaborative work with English as a Second Language (ESL) learners to critically review research data on lead exposures and reframe prevention messages about lead contamination of imported foods. These messages are now integrated into ESL curricula for dissemination to Spanish-speaking populations that are disproportionately affected by lead poisoning. This 'learners as interpreters' approach is a participatory method that can be applied across a wide range of public health activities. ESL learners emerged as ideal partners in developing curriculum for lead poisoning prevention for several reasons: the parents expressed strong interest in lead poisoning prevention, several have children under age 6 when lead screenings are recommended, and many have emigrated from regions in Mexico where lead hazards were identified.

  19. Small copper-doped silicon clusters CuSin (n = 4-10) and their anions: structures, thermochemistry, and electron affinities.

    PubMed

    Lin, Lin; Yang, Jucai

    2015-06-01

    The structures and energies of copper-doped small silicon clusters CuSi n (n = 4-10) and their anions were investigated systematically using CCSD(T)/aug-cc-pVTZ-DK//MP2/6-31G(2df,p), G4//MP2/6-31G(2df,p), and the B3LYP/6-311+G* basis set. The performance of the methods used for the prediction of energetic and thermodynamic properties was evaluated. Comparing experimental [Xu et al. (2012) J Chem Phys 136:104308] and theoretical calculations, it was concluded that the CCSD(T) results are very accurate and exhibit the best performance; the mean absolute deviation from experimental data was 0.043 eV. The excellent agreement of vertical detachment energy (VDE) between experimental results and CCSD(T) calculations indicates that the ground state structures of CuSi n (-) (n = 4-10) presented in this paper are reliable. For CuSi10, assigning 2.90±0.08 eV to the experimental adiabatic electron affinity (AEA) and 3.90±0.08 eV to the VDE is more reasonable than to 3.46±0.08 eV and 3.62±0.08 eV, respectively, based on the CCSD(T) calculations and the previous photoelectron spectrum of CuSi10 (-) (Xu et al., op. cit.). The AEAs of CuSi n (n = 4-10), excluding CuSi7, are in excellent agreement with experimental data, showing that the ground state structures of CuSi n (n = 4-6, 8-10) reported in this paper are reliable. CuSi10 is suggested to be the smallest endohedral ground state structure. However, adding an additional electron to CuSi10 pulls out the Cu atom from the center location, forming an exohedral ground state structure of CuSi10 (-). The charge transfer and dissociation energy of Cu from CuSi n and their anions determined to examine the nature of bonding and their relative stabilities.

  20. On universal common ancestry, sequence similarity, and phylogenetic structure: the sins of P-values and the virtues of Bayesian evidence

    PubMed Central

    2011-01-01

    Background The universal common ancestry (UCA) of all known life is a fundamental component of modern evolutionary theory, supported by a wide range of qualitative molecular evidence. Nevertheless, recently both the status and nature of UCA has been questioned. In earlier work I presented a formal, quantitative test of UCA in which model selection criteria overwhelmingly choose common ancestry over independent ancestry, based on a dataset of universally conserved proteins. These model-based tests are founded in likelihoodist and Bayesian probability theory, in opposition to classical frequentist null hypothesis tests such as Karlin-Altschul E-values for sequence similarity. In a recent comment, Koonin and Wolf (K&W) claim that the model preference for UCA is "a trivial consequence of significant sequence similarity". They support this claim with a computational simulation, derived from universally conserved proteins, which produces similar sequences lacking phylogenetic structure. The model selection tests prefer common ancestry for this artificial data set. Results For the real universal protein sequences, hierarchical phylogenetic structure (induced by genealogical history) is the overriding reason for why the tests choose UCA; sequence similarity is a relatively minor factor. First, for cases of conflicting phylogenetic structure, the tests choose independent ancestry even with highly similar sequences. Second, certain models, like star trees and K&W's profile model (corresponding to their simulation), readily explain sequence similarity yet lack phylogenetic structure. However, these are extremely poor models for the real proteins, even worse than independent ancestry models, though they explain K&W's artificial data well. Finally, K&W's simulation is an implementation of a well-known phylogenetic model, and it produces sequences that mimic homologous proteins. Therefore the model selection tests work appropriately with the artificial data. Conclusions For K&W's artificial protein data, sequence similarity is the predominant factor influencing the preference for common ancestry. In contrast, for the real proteins, model selection tests show that phylogenetic structure is much more important than sequence similarity. Hence, the model selection tests demonstrate that real universally conserved proteins are homologous, a conclusion based primarily on the specific nested patterns of correlations induced in genetically related protein sequences. Reviewers This article was reviewed by Rob Knight, Robert Beiko (nominated by Peter Gogarten), and Michael Gilchrist. PMID:22114984

  1. Study of B0 → $\\bar{D}$*0 Decay and Measurement of sin(2β)

    SciTech Connect

    Bomben, Marco

    2007-09-18

    This thesis describes a measurement of a CP violating asymmetry in neutral B meson decays, 0 → $\\bar{D}$*0, where D*0 is a charmed meson and h0 is a light meson, performed on data collected by the BABAR experiment at the SLAC asymmetric-energy electron-positron collider PEP-II.

  2. Effective surface treatment for GaN metal-insulator-semiconductor high-electron-mobility transistors using HF plus N2 plasma prior to SiN passivation

    NASA Astrophysics Data System (ADS)

    Liu, Shih-Chien; Trinh, Hai-Dang; Dai, Gu-Ming; Huang, Chung-Kai; Dee, Chang-Fu; Yeop Majlis, Burhanuddin; Biswas, Dhrubes; Chang, Edward Yi

    2016-01-01

    An effective surface cleaning technique is demonstrated for the GaN metal-insulator-semiconductor high-electron-mobility transistor (MIS-HEMT) passivation process. In this study, dilute HF solution and in situ N2 plasma treatments were adopted to remove the native oxide and recover the nitrogen-vacancy defects at the GaN surface before device passivation. To investigate the correlation between the properties of the SiN/GaN interface and the device performance, the GaN MIS-HEMTs were characterized using current-voltage (I-V) measurement, capacitance-voltage (C-V) measurement, and X-ray photoelectron spectroscopy (XPS) analysis. With the application of this surface treatment technique, the device exhibits improved I-V characteristics with low leakage current, low dynamic ON-resistance, and good C-V response with a steep slope. Overall, the results reveal that the oxide-related bonds and nitrogen-vacancy defects at the SiN/GaN interface are the root cause of the GaN MIS-HEMTs performance degradation.

  3. [Use of glutamine in total parenteral nutrition of bone marrow transplant patients].

    PubMed

    Herrera-Martínez, Aura Dulcinea; Alhambra Expósito, María R; Manzano García, Gregorio; Molina Puertas, María J; Calañas Continente, Alfonso; Bahamondez Opazo, Rodrigo; Muñoz Jiménez, Concepción; Rojas Contreras, Rafael; Gálvez Moreno, María A

    2015-04-01

    La glutamina es un amioácido esencial para la síntesis de nucleótidos y una fuente de energía para la replicación celular, existe evidencia contradictoria respecto a los beneficios de su administración como parte de la nutrición parenteral en pacientes sometidos a trasplante de médula ósea (TMO). Más del 75% de los pacientes sometidos a trasplante de precursores hematopoyéticos, presentan durante su evolución complicaciones que comprometen el tracto digestivo, principalmente mucositis, limitando la ingesta oral, de allí la necesidad del uso de nutrición parenteral total (NPT) en estos casos. Objetivo: Analizar la relación entre uso de glutamina en la NPT de TMO y la evolución de complicaciones agudas como mucositis, EICH e infecciones, así como la estancia hospitalaria y los días de nutrición parenteral total. Material y métodos: Estudio observacional retrospectivo. Se incluyeron la totalidad de TMO con NPT entre 2007 y 2013 en nuestro hospital. Se analizaron días de hospitalización, días de soporte nutricional, uso de glutamina y complicaciones agudas. Los resultados se analizaron con el programa SPSS 15.0. Resultados: Se incluyeron 73 pacientes trasplantados, se dividieron en dos grupos según el aporte de glutamina siendo ambos grupos comparables entre sí. La edad media fue de 36,96±12,89 años. El 47,9% de los pacientes estudiados recibió suplemento de glutamina en la NPT. Los pacientes que recibieron glutamina tuvieron una estancia media de 31,49±7,41 días con 14,11±5,87 días de NPT en comparación a los que no recibieron glutamina con 32,16±7,99 y 15,50±7,71 días respectivamente (p=0,71 y 0,39). La duración de la mucositis en los pacientes que recibieron glutamina fue de 12,23±5,66 días comparado con 15,50±7,71 días en los que no recibieron glutamina (p=0,042).Se observaron grados severos de EICH (II, III) en un 20,6% de los pacientes sin glutamina en comparación al 13,7% en los que la recibieron (p=0,636). . Del total

  4. [The dementia of King Ferdinand VI and the year with no king].

    PubMed

    Fernandez-Menendez, S; Gonzalez-Gonzalez, J M; Alvarez-Antuna, V; Bobes, J

    2016-06-01

    Introduccion. Fernando VI fue rey de España entre 1746 y 1759. Su ultimo año de reinado se conoce como el año sin rey. Durante ese año, el monarca sufrio un rapido empeoramiento de sus condiciones mentales. La enfermedad generalmente ha sido atribuida a una condicion psiquiatrica primaria, generalmente por un trastorno bipolar. Desarrollo. Se realiza un estudio de investigacion en los archivos documentales españoles y bibliotecas en busca de informacion clinica sobre la enfermedad de Fernando VI. Se realiza una evaluacion y discusion clinica de la enfermedad del rey sobre la base de la informacion obtenida. Conclusiones. El inicio del empeoramiento clinico del ultimo año de Fernando VI empezo tras la muerte de su amada esposa. Los sintomas iniciales descritos pueden ser similares a los de un episodio depresivo mayor, sin embargo, el monarca sufrio un empeoramiento rapidamente progresivo con alteraciones de la personalidad, conductuales, encamamiento, perdida de control de esfinteres y crisis epilepticas. Los ultimos meses de su vida estuvo en un estado de postracion con un estado cognitivo compatible con una demencia grave. Por todo ello, aunque es posible que Fernando VI pudiera padecer previamente algun tipo de trastorno psiquiatrico, la enfermedad que le llevo a su muerte precoz seria compatible con lo que hoy conocemos como una demencia rapidamente progresiva.

  5. Effect of binge eating disorder on the outcomes of laparoscopic gastric bypass in the treatment of morbid obesity.

    PubMed

    García Díaz, Eduardo; Jerez Arzola, María Elena; Martín Folgueras, Tomás; Morcillo Herrera, Luis; Jiménez Sosa, Alejandro

    2013-01-01

    Introducción: Los estudios previos sobre el efecto del trastorno por atracón en los resultados del tratamiento de la obesidad mediante bypass gástrico por vía laparoscópica (LGBP) son controvertidos. Faltan trabajos que comparen a pacientes con y sin trastorno por atracón según el sistema BAROS, que incluye: el porcentaje de sobrepeso perdido, la evolución de las comorbilidades, la calidad de vida y las complicaciones. Objetivo: Estudiar si el trastorno por atracón predispone a peores resultados tras el LGBP en los términos que definen el sistema BAROS. Métodos: En un estudio de cohortes con 45 obesos mórbidos intervenidos mediante LGBP, se identificó a los pacientes con trastorno por atracón prequirúrgico mediante el Questionnaire on Eating and Weight Patterns- Revised y se valoró sus resultados según los parámetros incluidos en el sistema BAROS. Resultados: El 21,4% de los pacientes presentaban trastorno por atracón. La mediana de seguimiento postoperatorio fue 12 meses. Los pacientes con trastorno por atracón presentaron menor tasa de resolución de la hipertensión arterial (42,9% frente a 92,9%; p = 0,025) y mayor frecuencia de estenosis de la anastomosis gastroyeyunal (70% frente al 17,1%; p = 0,003) que los pacientes sin trastorno por atracón. No se encontraron diferencias entre los grupos con y sin trastorno por atracón respecto al porcentaje de sobrepeso perdido, calidad de vida y puntuación global BAROS. Conclusiones: Los obesos con trastorno por atracón presentan tras el LGBP menores tasas de resolución de la hipertensión arterial y se complican más frecuentemente con una estenosis de la anastomosis gastroyeyunal. La valoración BAROS, la pérdida de peso y la calidad de vida son equiparables a la de los pacientes sin trastornopor atracón.

  6. [Fibromatosis breast in the male. Case study].

    PubMed

    Muñoz-Atienza, Virginia; Manzanares-Campillo, María Del Carmen; Sánchez-García, Susana; Pardo-García, Ricardo; Martín-Fernández, Jesús

    2013-01-01

    Antecedentes: la fibromatosis mamaria es una enfermedad rara; sus casos son 0.2% de las neoplasias de mama, y en los varones es aún más rara. El diagnóstico definitivo es anatomopatológico. Caso clínico: se comunica el caso de un varón de 52 años, con diagnóstico anatomopatológico de fibromatosis mamaria posterior al estudio de un tumor en la mama derecha. Se le practicó exéresis con amplios márgenes, luego mastectomía subcutánea, con estudio histológico de fibromatosis con márgenes libres. El postoperatorio transcurrió sin complicaciones y no requirió tratamiento coadyuvante. En el seguimiento a seis meses continuaba libre de enfermedad. El tratamiento de elección es la escisión con amplios márgenes y el oncológico coadyuvante es motivo de controversia. Conclusiones: la fibromatosis en la mama es poco frecuente y su aparición en el varón excepcional. El tratamiento quirúrgico es el definitivo, no así la terapia oncológica neoadyuvante que sigue suscitando controversia.

  7. Infratentorial angioleiomyoma: case report and review of the literature.

    PubMed

    Delgado-Fernandez, Juan; Penanes, Juan R; Torres, Cristina V; Gordillo-Velez, Carlos H; Manzanares-Soler, Rafael; Sola, Rafael G

    2016-01-16

    Introduccion. Los angioleiomiomas intracraneales son lesiones muy poco frecuentes. Solo se han descrito 22 casos en la bibliografia hasta la actualidad, unicamente tres de ellos de localizacion infratentorial. Caso clinico. Varon de 43 años con un angioleiomioma infratentorial descubierto de forma incidental tras la realizacion de una tomografia computarizada por hipoacusia. La resonancia magnetica mostro una tumoracion de 1,4 cm, descrita inicialmente como un meningioma, con un realce progresivo tras la administracion de gadolinio, un aumento del coeficiente de difusion aparente y un descenso generalizado de metabolitos en la espectroscopia. La lesion se reseco quirurgicamente mediante un abordaje suboccipital con buena evolucion y sin complicaciones postoperatorias. En el estudio histologico, la lesion presentaba un abundante componente vascular, y en la tincion inmunohistoquimica era positiva para actina y caldesmona. Dos años despues de la cirugia, el paciente no presentaba recurrencia en la resonancia magnetica de control. Conclusion. El diagnostico de los angioleiomiomas puede ser complejo, pero algunas de sus caracteristicas radiologicas pueden facilitarlo. Los angioleiomiomas son tumores benignos asociados con un resultado funcional favorable tras su reseccion completa, que en nuestro caso no presento un alto riesgo de sangrado.

  8. ORGANIC INFLAMMATORY RESPONSE TO REDUCED PREOPERATIVE FASTING TIME, WITH A CARBOHYDRATE AND PROTEIN ENRICHED SOLUTION; A RANDOMIZED TRIAL.

    PubMed

    de Andrade Gagheggi Ravanini, Guilherme; Portari Filho, Pedro Eder; Abrantes Luna, Renato; Almeida de Oliveira, Vinicius

    2015-08-01

    Introducción: El objetivo de este estudio es la evaluación de la respuesta inflamatoria orgánica a la colecistectomía laparoscópica mediante vídeo con una reducción del tiempo de ayuno preoperatorio a 2h y empleando una solución enriquecida con carbohidratos y proteínas. Métodos: Se trata de un estudio aleatorizado, prospectivo con pacientes divididos en los dos grupos siguientes: grupo A, ayuno convencional y grupo B, ayuno abreviado de 2h con ingesta oral de una solución enriquecida con carbohidratos y proteínas. Antes de la ingesta de la solución, se hicieron mediciones de glucosa sérica, insulina, interleucina 1y TNF-α; también se realizaron mediciones durante la inducción de la anestesia y 4h después de la intervención quirúrgica. Resultados: Treinta y ocho pacientes completaron el estudio sin presentar complicaciones pulmonares relacionadas con el broncoaspirado. La varianza HOMA-IR postoperatoria fue superior en el grupo A (p = 0,001). Conclusión: La reducción del tiempo de ayuno preoperatorio a 2h, empleando soluciones enriquecidas con carbohidratos y proteínas, es segura, reduce la resistencia a la insulina, y no aumenta el riesgo de broncoaspirado.

  9. [Familial microepidemic of food-borne botulism in the Region of Madrid].

    PubMed

    Jalda, D; Junco, A; Alvarez-Moreno, M; Rodero, I; Carneado-Ruiz, J

    2016-07-01

    Introduccion. El botulismo es un sindrome causado por la toxina del bacilo Clostridium botulinum. La toxina actua bloqueando las terminaciones colinergicas presinapticas de la placa motora y del sistema nervioso parasimpatico, y ocasiona una paralisis flacida y un fallo parasimpatico. El modo mas habitual de adquisicion de la enfermedad es por ingesta de toxina preformada presente en las conservas caseras mal esterilizadas, aunque otros mecanismos son posibles. Su incidencia actual en Espana es muy baja. Casos clinicos. Se describen tres miembros convivientes de una familia que presentaron un cuadro de botulismo alimentario. Las manifestaciones clinicas iniciales mostraron predileccion por la paresia ocular y por sintomatologia disautonomica de escasa especificidad, y la agregacion familiar fue el indicio fundamental que sugirio el diagnostico. Posteriormente, los pacientes empeoraron y dos de ellos presentaron afectacion de la funcion respiratoria y precisaron ingreso prolongado en la unidad de cuidados intensivos. Los tres pacientes convalecieron y se recuperaron sin secuelas. Se consiguio detectar la toxina botulinica por bioensayo en los restos de alimentos, lo que confiere al caso la categoria diagnostica de confirmado. Conclusiones. La microepidemia familiar presentada constituye un caso de afectacion inicial predominantemente ocular y disautonomica. Asimismo, ilustra varios aspectos tipicos de la enfermedad: la sospecha diagnostica ante pacientes convivientes que acuden simultaneamente por clinica similar, las complicaciones caracteristicas del proceso y su tratamiento, el diagnostico de laboratorio y su historia natural hacia la resolucion.

  10. [Epileptic seizures complicated by Takotsubo syndrome].

    PubMed

    Garea Garcia-Malvar, M J; Gonzalez-Silva, Y; Epureanu-Epureanu, V

    2014-11-01

    Introduccion. El sindrome de takotsubo es un trastorno caracterizado por disfuncion ventricular reversible, dolor precordial de tipo anginoso y cambios electrocardiograficos sin evidencia de obstruccion coronaria en coronariografia. Se desencadena por estres, y es frecuente tras crisis epilepticas. Presentamos el caso de una paciente que inicia esta miocardiopatia tras una crisis epileptica al finalizar su sesion de hemodialisis. Caso clinico. Mujer de 55 años en hemodialisis por insuficiencia renal cronica, con epilepsia secundaria a lesion residual frontoparietal derecha por un hematoma que preciso evacuacion quirurgica. Tras una sesion de hemodialisis experimenta una crisis epileptica focal con generalizacion secundaria y, horas despues de esta, dolor centrotoracico. En seriacion enzimatica se objetiva elevacion de troponina I y, electrocardiograficamente, ondas T negativas en derivaciones precordiales (V2-V6). Se realiza coronariografia, cuyo resultado es normal, y se demuestran alteraciones de la contractilidad, confirmadas como de caracter transitorio en un estudio ecocardiografico seriado. Todos los datos anteriores hacen sospechar el diagnostico de sindrome de takotsubo. Conclusion. Las complicaciones cardiacas son una de las causas de morbimortalidad en la epilepsia, y entre ellas se encuentra el sindrome de takotsubo. La incidencia real de dicho sindrome se desconoce, pero dada su implicacion en la mortalidad de causa cardiaca en la epilepsia es importante sospecharlo ante la presencia de disfuncion cardiaca tras una crisis epileptica.

  11. [Mortality-associated factors in pediatric patients with Blalock-Taussig shunt].

    PubMed

    Aguilar-Segura, Perla Roxana; Lazo-Cárdenas, César; Rodríguez-Hernández, Lydia; Márquez-González, Horacio; Giménez-Scherer, Juan Antonio

    2014-01-01

    INTRODUCCIÓN: la supervivencia de los pacientes con cardiopatía congénita con flujo pulmonar disminuido ha aumentado debido a las técnicas de anastomosis quirúrgica entre la circulación sistémica y la pulmonar, sin embargo, pueden presentarse complicaciones. El objetivo de este estudio fue determinar los factores quirúrgicos y bioquímicos relacionados con la muerte en pacientes pediátricos en quienes se realizó derivación de Blalock-Taussig modificada. MÉTODOS: se integró una cohorte de neonatos con cardiopatía congénita sometidos a derivación tipo Blalock-Taussig que sobrevivieron a la cirugía. Al ingreso a cuidados intensivos se documentó tiempo quirúrgico, diámetro del injerto vascular de politetrafluoroetileno, gasometría arterial y saturación venosa central de oxígeno. Se dio seguimiento hasta el egreso o defunción. Para el análisis estadístico se utilizaron medidas de tendencia central y dispersión, chi cuadrada, razón de momios, modelo de regresión de Cox, hazard ratio (HR) y curva de Kaplan-Meier, para la variable más independiente.

  12. [Hemorrhagic colloid cyst of the third ventricle: fulminant deterioration].

    PubMed

    Martínez-Gómez, Debora; Joanes, Vicente; Herrera, Juan Manuel; Rivera-Paz, Marlon; Vanaclocha, Vicente

    2015-03-16

    Introduccion. Los quistes coloides son tumores benignos del tercer ventriculo. La mayoria permanecen asintomaticos. Sin embargo, algunos pacientes pueden desarrollar desde cefaleas intermitentes hasta un deterioro agudo e incluso muerte subita. Existen varias teorias por las que se produciria una muerte subita en estos pacientes, entre las que se incluyen el rapido crecimiento del quiste, su rotura, la alteracion del control cardiovascular reflejo mediado por el hipotalamo y, rara vez, el sangrado del quiste, con solo 15 casos descritos en la bibliografia. Caso clinico. Varon de 45 años, con hipertension arterial como unico antecedente de interes, que sufre un deterioro brusco del nivel de consciencia a causa de una hidrocefalia aguda debida a un quiste coloide hemorragico del tercer ventriculo. Se implanto un drenaje ventricular externo en cada lado e ingreso en la unidad de cuidados intensivos, donde se certifico la muerte encefalica. Tras la extirpacion del quiste mediante abordaje transcortical frontal, se confirmo el diagnostico de quiste coloide con restos de material hemolizado subagudo. Conclusion. La hemorragia en los quistes coloides es excepcional y puede producirse en pacientes tanto sintomaticos como asintomaticos, lo que dificulta, de forma extraordinaria, el reconocimiento de esta complicacion.

  13. [Acute posterior multifocal placoid pigment epitheliopathy. A rare cause of ischaemic stroke].

    PubMed

    del Saz-Saucedo, Pablo; Alfaya-Muñoz, Laura Blanca; Recio-Bermejo, Marta; Lara-Medina, Francisco Javier; García-Chiclano, Amalia; Ortega-León, Teresa; Rueda-Medina, Ignacio; Domínguez-Fernández, María José; Madrid-Muñiz, Carmen; Franco-Huerta, María

    2013-06-01

    Introduccion. La epiteliopatia pigmentaria placoide multifocal posterior aguda (EPPMPA) es una enfermedad inflamatoria rara, generalmente de etiologia indeterminada, de la coriocapilar, el epitelio pigmentario y la retina externa. Afecta predominantemente a pacientes jovenes y en algunos casos puede involucrar al sistema nervioso central en forma de ictus o de meningoencefalitis. Presentamos el caso clinico de una mujer joven con EPPMPA complicada con ictus e hipertension intracraneal. Caso clinico. Mujer de 16 anos que comienza con cefalea intensa sugestiva de hipertension intracraneal, asi como con un deficit agudo hemisferico izquierdo. La resonancia magnetica craneal ponia de manifiesto lesiones embolicas o vasculiticas en diferentes territorios. No se evidenciaron datos de meningoencefalitis en el estudio del liquido cefalorraquideo, pero si de hipertension intracraneal asociada. La presencia de lesiones muy especificas en el polo ocular posterior permitio el diagnostico de EPPMPA complicada con ictus isquemico, probablemente por mecanismo vasculitico. Un amplio estudio etiologico fue negativo para identificar un factor desencadenante claro del proceso. Se inicio tratamiento corticoideo con buena evolucion clinica y radiologica. Conclusiones. La EPPMPA es una entidad rara que generalmente entrana buen pronostico; sin embargo, en algunos casos puede complicarse con afectacion del sistema nervioso central, y el ictus isquemico secundario a vasculitis es la complicacion mas grave. Ante un paciente joven con ictus que presente sintomatologia visual y lesiones coriorretinianas, debe considerarse la EPPMPA en su diagnostico etiologico.

  14. [Not Available].

    PubMed

    Monereo Megías, Susana; Arnoriaga Rodríguez, María; Olmedilla Ishishi, Yoko Lucía; Martínez de Icaya, Purificación

    2016-01-01

    La obesidad es una enfermedad muy prevalente con múltiples complicaciones crónicas que se reducen o desaparecen tras pérdidas pequeñas (5-10%) pero mantenidas de peso. Sin embargo, mantener la pérdida de peso tras el tratamiento es muy difícil, siendo uno de los mayores retos en el control de esta enfermedad. Aunque las razones que contribuyen a recuperar el peso perdido son de diversa índole, relacionadas con la respuesta biológica a la restricción calórica y con la pérdida de adherencia al tratamiento, hasta un 20% de los pacientes son capaces de mantenerlo. Las claves del éxito están relacionadas con el mantenimiento de los hábitos de vida saludable, el ejercicio físico y una ingesta calórica razonable que permita realizar una vida normal, sin pérdida de vida social. En este sentido, aprender a distinguir las opciones de comida y bebida en una sociedad donde la vida social gira en torno a la mesa en muchas ocasiones es muy importante. Revisamos en este artículo las claves para mantener el peso tras una dieta, así como el papel de las bebidas fermentadas, en especial, la cerveza, en este proceso. En conclusión, mantener el peso perdido es más difícil que perderlo. El consumo leve-moderado de bebidas fermentadas como la cerveza no se asocia con incremento del peso. PMID:27571862

  15. [Use of intravenous immunoglobulin in pregnancy. Report of a patient with common variable immunodeficiency].

    PubMed

    Cambray-Gutiérrez, Julio César; García-Ramírez, Ulises Noel; Del Rivero-Hernández, Leonel Gerardo; López-Pérez, Patricia; Chávez-García, Aurora

    2016-01-01

    Antecedentes: La inmunodeficiencia común variable es la inmunodeficiencia primaria más diagnosticada en los adultos; se caracteriza por infecciones sinopulmonares y gastrointestinales de repetición y mayor incidencia de procesos autoinmunes y malignidad. Numerosos pacientes inician con las manifestaciones clínicas durante la edad reproductiva. Caso clínico: Mujer de 34 años de edad con 12 semanas de gestación, en quien se diagnosticó inmunodeficiencia común variable después de cuadros recurrentes de rinosinusitis, faringoadmidalitis y neumonías. Durante el segundo trimestre se prescribió 0.6 g/kg de inmunoglobulina intravenosa cada 21 días; la paciente solo presentó un episodio de faringoamigdalitis, con adecuada respuesta al tratamiento con antibióticos. Durante el tercer trimestre se ajustó la dosis a cada 14 días. La paciente concluyó el embarazo a término sin complicaciones, con producto sin malformaciones y con peso y talla adecuados. Conclusiones: La administración de inmunoglobulina es el principal tratamiento para controlar la inmunodeficiencia común variable. Si bien la dosis inicial recomendada es de 400-800 mg/kg en forma intravenosa cada 3 a 4 semanas, no existe un consenso sobre la dosis que debe emplearse en la mujer que cursa con embarazo. La recomendación es realizar controles de niveles séricos antes de la infusión para determinarla y ajustarla.

  16. [Sigmoid diverticulitis in adolescent. Case report].

    PubMed

    Valenzuela-Salazar, Carlos; Orozco-Tapia, Luis Manuel; de la Concha Blankenagel, Erika; Gallardo-Ramírez, Mario Alberto; Blas-Franco, Miguel; Cárdenas-Lailson, Luis Eduardo

    2013-01-01

    Antecedentes: la enfermedad diverticular colónica en niños y adolescentes es poco frecuente y sólo existen reportes de casos aislados en la bibliografía. La mayoría de los casos reportados se asocian con divertículos verdaderos congénitos y enfermedades genéticas de producción de la colágena. Caso clínico: paciente femenina de 13 años de edad, que ingresó a la División de Cirugía General y Endoscópica con diagnóstico de apendicitis aguda complicada. En la laparotomía se encontró enfermedad diverticular complicada de colon sigmoides. Se le practicó sigmoidectomía y colorrecto-anastomosis. El reporte histopatológico evidenció perforación de pseudodivertículo de colon sigmoides y peritonitis. La paciente fue dada de alta del hospital 72 horas posteriores a la cirugía, sin complicaciones. Conclusión: existen sólo reportes de casos aislados de niños y adolescentes con diverticulitis colónica, y su etiología no ha sido aún debidamente establecida. Esta paciente tuvo diverticulitis de sigmoides, similar a la enfermedad en adultos, sin padecimientos genéticos concomitantes. El caso es una excepción a lo reportado en la bibliografía de las diverticulitis en niños y adolescentes.

  17. [Not Available].

    PubMed

    Monereo Megías, Susana; Arnoriaga Rodríguez, María; Olmedilla Ishishi, Yoko Lucía; Martínez de Icaya, Purificación

    2016-07-12

    La obesidad es una enfermedad muy prevalente con múltiples complicaciones crónicas que se reducen o desaparecen tras pérdidas pequeñas (5-10%) pero mantenidas de peso. Sin embargo, mantener la pérdida de peso tras el tratamiento es muy difícil, siendo uno de los mayores retos en el control de esta enfermedad. Aunque las razones que contribuyen a recuperar el peso perdido son de diversa índole, relacionadas con la respuesta biológica a la restricción calórica y con la pérdida de adherencia al tratamiento, hasta un 20% de los pacientes son capaces de mantenerlo. Las claves del éxito están relacionadas con el mantenimiento de los hábitos de vida saludable, el ejercicio físico y una ingesta calórica razonable que permita realizar una vida normal, sin pérdida de vida social. En este sentido, aprender a distinguir las opciones de comida y bebida en una sociedad donde la vida social gira en torno a la mesa en muchas ocasiones es muy importante. Revisamos en este artículo las claves para mantener el peso tras una dieta, así como el papel de las bebidas fermentadas, en especial, la cerveza, en este proceso. En conclusión, mantener el peso perdido es más difícil que perderlo. El consumo leve-moderado de bebidas fermentadas como la cerveza no se asocia con incremento del peso.

  18. EFFECT OF ANTIOXIDANT POTENTIAL ON SEVERITY OF CIRRHOSIS IN HUMANS.

    PubMed

    Colpo, Elisangela; Gomes Farias, Julia; Gomes Farias, Iria Luiza; Brenner Reetz, Luiz Gustavo; Oliveira, Liliane; Michelon de Carli, Diego; Irineu Müller, Edson; Marlon de Moraes Flores, Érico; Roth Dalcin, Saulo; Teixeira da Rocha, João Batista

    2015-11-01

    Introducción/Objetivos: examinar la relación entre los potenciales antioxidantes y los parámetros de gravedad de la cirrosis en los seres humanos. Métodos: quince pacientes con cirrosis hepática (nueve sujetos - grupo Child B, y seis sujetos - grupo Child C) y nueve sujetos control fueron incluidos en el estudio. Los principales criterios que se tuvieron en cuenta para caracterizar el diagnóstico de la cirrosis y sus complicaciones fueron la AST: relación de ALT, AST índice de la relación de plaquetas, clasificación Bonacini, clasificación MELD y clasificación de Child. Estos parámetros fueron determinados con base en los resultados de laboratorio y los registros clínicos del paciente. Se midieron los niveles de Zn, ácido ascórbico (AA) y los parámetros de estrés oxidativo en muestras de sangre de pacientes cirróticos. Resultados: el análisis de los niveles plasmáticos de Se y AA mostraron bajas concentraciones en los pacientes cirróticos en comparación con los sujetos control (P < 0,05); sin embargo, hubo una correlación positiva entre el plasma de Se y los parámetros de gravedad de la cirrosis en pacientes del grupo Child B y C. En la actividad de las enzimas antioxidantes catalasa solamente fue menor en los pacientes del grupo Child C, en comparación con el grupo control. Conclusión: se encontraron niveles bajos en plasma de Se y AA en pacientes cirróticos. Sin embargo, no está claro por qué los niveles de selenio tienden a aumentar con la gravedad de la cirrosis hepática.

  19. Clinical effects of a hypercaloric and hyperproteic oral suplemment enhanced with W3 fatty acids and dietary fiber in postsurgical ambulatory head and neck cancer patients.

    PubMed

    de Luis, D A; de la Fuente, B; Izaola, O; Martin, T; Cuellar, L; Terroba, M C

    2014-11-30

    Antecedentes: Los pacientes con tumores de cabeza y cuello sometidos a cirugía presentan un alto riesgo de complicaciones nutricionales. Objetivo: El principal objetivo de nuestro trabajo fue evaluar la influencia de un suplemento hiperenergético e hiperproteico enriquecido en ácidos grasos w3 y fibra en pacientes postquirúrgicos ambulatorios con tumores de cabeza y cuello, con y sin radioterapia. Diseño: Una muestra de 37 pacientes postquirúrgicos ambulatorios con tumores de cabeza y cuello fue evaluada. Tras el alta hospitalaria, los pacientes recibieron dos envases al día de un suplemento hiperproteico e hipercalórico durante 12 semanas. Resultados: La edad media fue de 63.8+/-7.1 años (16 mujeres/21 varones). La duración media de la suplementación fue de 98.1±19.1 días. Se detectó un aumento significativo en los niveles de albúmina y transferrina en los pacientes del grupo global, en los que recibieron radioterapia y en los que no al recibieron. El peso y los parámetros antropométricos no mejoraron en el grupo global ni en los que recibieron radioterapia. Sin embargo los pacientes que no recibieron radioterapia tuvieron un aumento de la masa magra, peso y masa grasa Conclusiones: La formula enriquecida en omega 3 y fibra mejoró lo niveles de proteínas séricas. Por otra parte los pacientes que no recibieron radioterapia durante el seguimiento presentaron un aumento del peso, masa grasa y masa magra.

  20. [SOMATOTYPE, NUTRITIONAL STATUS AND BLOOD GLUCOSE LEVEL OF PHYSICAL EDUCATION STUDENTS].

    PubMed

    Valdés-Badilla, Pablo; Salvador Soler, Noemí; Godoy-Cumillaf, Andrés; Carmona-López, María Ines; Fernández, Juan José; Durán-Agüero, Samuel

    2015-09-01

    Introducción: en general, los estudios tanto en niños como en adultos han comparado la glucemia según estado nutricional, sin embargo no se conocen investigaciones que consideren el somatotipo de los sujetos. Objetivo: asociar el somatotipo, el estado nutricional y el nivel de glucemia de estudiantes de Pedagogía en Educación Física (PEF). Método: la muestra incluyó 40 sujetos, divididos en 13 mujeres y 27 varones. Se determinó en cada sujeto el IMC, el somatotipo y, además, se obtuvo una muestra de glucemia en ayuno. Resultados: el somatotipo de los estudiantes varones de PEF fue mesoendomorfo (3-2-2) con un estado nutricional de sobrepeso (25 kg/m2), las mujeres de PEF se clasificaron como mesoendomofas balanceadas (4-4-2) con normopeso (22 kg/m2), mientras que los valores promedio de glucemia en ayunas fueron de 69 mg/dl. No se encontró asociación entre el somatotipo y los niveles de glucemia de los estudiantes de PEF, sin embargo, en el caso de las mujeres de PEF, se observaron correlaciones positivas significativas entre la mesomorfía y el ICC (0,577) y entre la glucemia y la estatura (0,650). Conclusión: el somatotipo y el IMC de los estudiantes de PEF son concordantes con su edad y sexo, sin evidenciar asociación entre somatotipo y glucemia. Por otra parte, los valores promedio de glucemia son algo menores respecto a tablas normativas, situación que podría relacionarse con la práctica de actividad física; no obstante, se requiere de mayor estudio para corroborarlo.

  1. [Behavior of blood glucose level with the administration of micronutrients vitamin d3 and calcium in nondiabetic patients with hyperglycemia in adult intensive care unit].

    PubMed

    Rueda Páez, Elsy Victoria; Moncada Parada, Esperanza; Figueroa Melgarejo, Jairo; Ascencio Higuera, Ana Airé

    2015-05-01

    La hiperglucemia sin antecedentes previos de diabetes mellitus (DM) se observa en un alto porcentaje en pacientes de unidades de cuidado intensivo (UCI). Objetivo: Determinar el comportamiento de cifras de glucemia en pacientes no diabéticos con hiperglucemia mediante la administración de 2 micronutrientes. Metodología: se realizó un ensayo clínico a 32 pacientes, 16 en el grupo a intervenir y 16 en el grupo control. Al grupo intervenido se le administró desde su ingreso los micronutrientes vitamina D3 en dosis de 1.000 unidades internacionales (UI) y calcio en dosis de 1.000 mg cada 24 horas por un periodo de 72 horas. Resultados: no se observaron diferencias estadísticamente significativas en la glucemia de ingreso entre los grupos intervenidos y control (152,6 y 153,3 mg/dl respectivamente (p= 0,922), sin embargo a las 72 horas el comportamiento de las glucemias disminuyó significativamente en el grupo intervenido comparado con el grupo control (98,41 y 141,66 mg/dl respectivamente p= < 0,000). Así mismo, se evidenció que la intervención con vitamina D3 y Calcio redujo el riesgo (47%) de desarrollo del evento indeseado (glucemia > 100 mg/dl), mostrando que se deben tratar 2.29 pacientes para disminuir el evento indeseable (NNT). Conclusión: la utilización de los micronutrientes analizados en pacientes críticos sin diagnóstico previo de diabetes requiere de más investigaciones que contemplen las limitaciones aquí planteadas. Dada la poca literatura encontrada de estudios similares, esta investigación proporcionaría otra alternativa en la disminución de la hiperglucemia de éstos pacientes.

  2. [Not Available].

    PubMed

    Pérez-Flores, Juan Emmanuel; Chávez-Tostado, Mariana; Larios-Del-Toro, Youné Elizabeth; García-Rentería, Jesús; Rendrón-Félix, Jorge; Salazar-Parra, Marcela; Irusteta-Jiménez, Leire; Michel-Espinoza, Luis Rodrigo; Márquez-Valdez, Aída Rebeca; Cuesta-Márquez, Lisbeth; Álvarez-Villaseñor, Andrea Socorro; Fuentes-Orozco, Clotilde; González Ojeda, Alejandro

    2016-07-19

    Introducción: la desnutrición intrahospitalaria se ha descrito hace más de 70 años como un problema frecuente. En México se reportan cifras de entre el 20% al 50%; sin embargo no se ha estudiado su prevalencia ni su asociación con la morbilidad y mortalidad hospitalaria.Objetivos: evaluar el estado nutricional y su relación con la morbimortalidad hospitalaria en pacientes mexicanos.Métodos: cohorte prospectiva de pacientes que ingresaron en un hospital de referencia para una estancia hospitalaria mayor de 5 días. Se capturó peso, talla, índice de masa corporal (IMC), estado nutricional de acuerdo con la valoración global subjetiva (VGS) a su ingreso y egreso hospitalario, así como diagnóstico médico, complicaciones y mortalidad. Los datos fueron analizados mediante la prueba T de Student, prueba Chi-cuadrado y prueba Exacta de Fisher.Resultados: se incluyeron 610 pacientes en total, con un promedio de edad de 50,8 ± 17,32 años, 267 mujeres (43,8%) y 343 hombres (56,2%). Del total, 154 fueron catalogados con sospecha de desnutrición o desnutrición (pacientes expuestos, 25,2%) y 456 bien nutridos (pacientes no expuestos, 74,8%), con una relación de 1 a 3. La morbilidad total de la cohorte tuvo un RR = 2,70, IC 95 % (2,06-3,55) y la mortalidad con un RR = 2,64, IC 95% (1,74-4,0), siendo ambas estadísticamente significativas (p = 0,001).Conclusiones: el diagnóstico de desnutrición al ingreso hospitalario constituye un factor de riesgo para el desarrollo de complicaciones y mortalidad. Este padecimiento al ingreso en comparación con el paciente que no presenta desnutrición incrementó el riesgo de mortalidad hasta en 2.64 veces.

  3. [Acute gastric volvulus: late complication of Nissen fundoplication. Report of two cases and review of the literature].

    PubMed

    Reyes-Zamorano, Jesús

    2014-01-01

    Antecedentes: el vólvulo gástrico puede clasificarse por su etiología en primario o secundario, por su anatomía en órgano axial o mesentérico axial y por su presentación en crónico o agudo. El tratamiento del vólvulo gástrico secundario agudo siempre debe ser quirúrgico y la elección del procedimiento basarse en la etiología y en los casos asociados con cirugía previa será importante la lisis de adherencias y el retiro de cuerpos extraños (material de sutura, mallas, banda gástrica). La funduplicatura Nissen es un procedimiento seguro y efectivo que rara vez puede tener complicaciones tardías severas entre las que se encuentran el vólvulo gástrico. Objetivo: comunicar 2 casos y revisar la bibliografía médica. Casos clínicos: se describen 2 casos de vólvulo gástrico agudo secundarios a funduplicatura tipo Nissen laparoscópica, con síntomas de dolor epigástrico y vómito no productivo, ambos tratados por laparoscopia. Se revisan los síntomas de presentación, incidencia, diagnóstico, tratamiento y los factores predisponentes de vólvulo gástrico postfunduplicatura. Conclusión: el vólvulo gástrico rara vez puede ser una complicación de una funduplicatura Nissen con incidencia similar a la de otras de sus complicaciones tardías. Los mecanismos descritos que lo originan se relacionan con adherencias postquirúrgicas, material de sutura (poliéster), mallas, tubos de gastrostomía, gastropexia y por herniación gástrica interna a través del túnel "transfunduplicatura." En pacientes con síntomas de obstrucción gástrica dentro del primer año posterior a una funduplicatura Nissen laparoscópica se requiere un alto índice de sospecha. El tratamiento quirúrgico laparoscópico es seguro con o sin gastropexia para corregir los mecanismos que lo originan.

  4. [Not Available].

    PubMed

    Pérez-Flores, Juan Emmanuel; Chávez-Tostado, Mariana; Larios-Del-Toro, Youné Elizabeth; García-Rentería, Jesús; Rendrón-Félix, Jorge; Salazar-Parra, Marcela; Irusteta-Jiménez, Leire; Michel-Espinoza, Luis Rodrigo; Márquez-Valdez, Aída Rebeca; Cuesta-Márquez, Lisbeth; Álvarez-Villaseñor, Andrea Socorro; Fuentes-Orozco, Clotilde; González Ojeda, Alejandro

    2016-01-01

    Introducción: la desnutrición intrahospitalaria se ha descrito hace más de 70 años como un problema frecuente. En México se reportan cifras de entre el 20% al 50%; sin embargo no se ha estudiado su prevalencia ni su asociación con la morbilidad y mortalidad hospitalaria.Objetivos: evaluar el estado nutricional y su relación con la morbimortalidad hospitalaria en pacientes mexicanos.Métodos: cohorte prospectiva de pacientes que ingresaron en un hospital de referencia para una estancia hospitalaria mayor de 5 días. Se capturó peso, talla, índice de masa corporal (IMC), estado nutricional de acuerdo con la valoración global subjetiva (VGS) a su ingreso y egreso hospitalario, así como diagnóstico médico, complicaciones y mortalidad. Los datos fueron analizados mediante la prueba T de Student, prueba Chi-cuadrado y prueba Exacta de Fisher.Resultados: se incluyeron 610 pacientes en total, con un promedio de edad de 50,8 ± 17,32 años, 267 mujeres (43,8%) y 343 hombres (56,2%). Del total, 154 fueron catalogados con sospecha de desnutrición o desnutrición (pacientes expuestos, 25,2%) y 456 bien nutridos (pacientes no expuestos, 74,8%), con una relación de 1 a 3. La morbilidad total de la cohorte tuvo un RR = 2,70, IC 95 % (2,06-3,55) y la mortalidad con un RR = 2,64, IC 95% (1,74-4,0), siendo ambas estadísticamente significativas (p = 0,001).Conclusiones: el diagnóstico de desnutrición al ingreso hospitalario constituye un factor de riesgo para el desarrollo de complicaciones y mortalidad. Este padecimiento al ingreso en comparación con el paciente que no presenta desnutrición incrementó el riesgo de mortalidad hasta en 2.64 veces. PMID:27571661

  5. TRAQUEOESOPHAGEAL FISTULA PATIENTS FED THROUGH PERCUTANEOUS ENDOSCOPIC GASTROSTOMY/GASTROJEJUNOSTOMY: NUTRITIONAL STATUS AND CLINICAL OUTCOME.

    PubMed

    Santos, Carla Adriana; Pereira, Marta; Martins, Vera Santos; Fonseca, Jorge

    2015-08-01

    Introducción: las fístulas traqueoesofágicas (FTE) pueden surgir en un cáncer de esófago/pulmón o pueden ser secundarias a intubación endotraqueal prolongada. La Gastrostomía Percutánea Endoscópica o la Gastroyeyunostomía (PEG/PEG-J) son útiles para el soporte nutricional. Intentamos evaluar: estado nutricional cuando los pacientes son referenciados/sometidos a gastrostomía, evolución clínica y seguridad de la PEG/ PEG-J en la FTE. Materiales y métodos: pacientes con FTE alimentados por PEG/PEG-J: características clínicas, índice de masa corporal, albúmina, transferrina, colesterol, evaluados en el día de la gastrostomía, y según la causa de la FTE: Grupo 1: complicación de la ventilación mecánica; Grupo 2: cáncer esofágico o respiratorio. Resultados: doce pacientes, mediana de edad 53 años (18-91), 11 PEG, 1 PEG-J: 6 complicaciones de la ventilación mecánica; 6 cánceres. Periodo de referencia entre el diagnóstico de TEF y la gastrostomía: 2 meses en el Grupo 1, 10 meses en el Grupo 2. En el momento de la gastrostomía la mayoría estaban desnutridos, en particular el Grupo 2. En el Grupo 1 solo falleció un paciente, 3 regresaron a la alimentación oral después de cerrar la FTE, 2 mantienen la gastrostomía. Todos los pacientes oncológicos murieron (mediana: 7 meses después la PEG). Uno requirió una extensión yeyunal para PEG-J. Sin otras complicaciones. Conclusión: en nuestra experiencia, la PEG/PEG - J fue un método seguro en pacientes con FTE de causa oncológica u otra, pero los pacientes con cáncer son sometidos a gastrostomía muy tarde. En los pacientes con FTE la PEG/PEG -J se debe considerar antes de que se produzca la malnutrición.

  6. Concepciones y concepciones alternativas de estudiantes universitarios/as de biologia y futuros maestros/as de Ciencia de escuela secundaria sobre la teoria de evolucion biologica por seleccion natural

    NASA Astrophysics Data System (ADS)

    Morales Ramos, Egda M.

    La teoria de evolucion biologica (TEB) por seleccion natural es uno de los conceptos unificadores mas importantes del curriculo de Biologia. En Puerto Rico se han hecho pocas investigaciones que abunden sobre las concepciones y concepciones alternativas (CA) que tienen los estudiantes universitarios/as de Biologia y los maestros/as de Ciencia del nivel secundario sobre esta teoria. La politica publica educativa actual establece mediante documentos normativos como los Estandares de contenido y Expectativas de grado del Programa de Ciencias [Puerto Rico Core Standards] la ensenanza de esta teoria. Sin embargo, no se encontraron preguntas sobre la seleccion natural en los ejercicios de practica provistos por el Departamento de Educacion para las pruebas estandarizadas lo cual puede influir para que no se ensene adecuadamente. Las preguntas de investigacion fueron 1. ¿Cuales son las concepciones y concepciones alternativas de estudiantes universitarios/as y de los futuros maestros y maestras de Ciencia sobre la TEB? 2. ¿Cuales conceptos que seleccionan los estudiantes universitarios/as y los futuros maestros y maestras de Ciencia sobre la TEB coinciden con lo aceptado como valido por la comunidad cientifica? y 3. ¿Como comparan las respuestas de la prueba original. v. Entendiendo el cambio biologico que mide concepciones y CA sobre la TEB por seleccion natural, con las de la traducida al idioma espanol? Se utilizo el metodo cuantitativo con un diseno de investigacion transversal por encuesta. La tecnica principal para recopilar los datos fue una prueba con doce items, que formo parte de un instrumento para el cual se recopilaron diversas fuentes de evidencia acerca de su validez. Las muestras estuvieron formadas por 69 estudiantes de Ciencias Naturales y por 16 estudiantes futuros maestros y maestras del nivel secundario de la UPR-RP. Se utilizaron estadisticas descriptivas, analisis de Ji cuadrado y se calcularon los coeficientes alfa de Cronbach y de Spearman

  7. [Isolated splenic metastases from cervical cancer: a rare entity].

    PubMed

    Villalón-López, José Sebastián; Souto-del Bosque, Rosalía; Montañez-Lugo, Juan Ignacio; Chávez-González, Bruno

    2014-01-01

    Antecedentes: las metástasis al bazo por tumores sólidos son excepcionales, su incidencia es apenas de 2.9 a 9%. Las metástasis esplénicas por cáncer cervicouterino son infrecuentes, solo se han reportado algunos casos. Caso clínico: paciente femenina de 76 años de edad, con adenocarcinoma de endocervix moderadamente diferenciado; con invasión al estroma cervical y al canal endocervical, etapa clínica Ib1; el Ca-125 de 150 U. Se trató con histerectomía y linfadenectomía pélvica. Recibió radioterapia pélvica 45 Gy, seguida de braquiterapia 24 Gy. Dos años después tuvo dolor abdominal y, en una tomografía, se encontraron dos lesiones parenquimatosas esplénicas sin existir enfermedad en el resto de la cavidad abdominal y el tórax, tiene elevación del Ca-125 de 2,733 U. Se le realizó esplenectomía; el reporte histopatológico demostró metástasis esplénicas de adenocarcinoma bien diferenciado del endocervix. El estudio de inmunohistoquímica mostró positividad al antígeno carcinoembrionario, los receptores de estrógeno y progesterona resultaron negativos. El Ca-125 de 16 U/mL a ocho semanas de la cirugía. Recibió tratamiento adyuvante, seis ciclos con paclitaxel y cisplatino. A 12 meses de seguimiento la paciente está viva y sin actividad tumoral. Conclusiones: el bazo es un sitio poco común de metástasis. La esplenectomía se ha considerado el tratamiento apropiado para evitar complicaciones como: ruptura esplénica, trombosis de la vena esplénica y disminución del dolor originado por la esplenomegalia. Doce meses después de la cirugía la paciente está viva y sin evidencia de actividad tumoral.

  8. Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos

    PubMed Central

    Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

    2014-01-01

    Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos. PMID:25580466

  9. The spectroscopic binary system Gl 375. I. Orbital parameters and chromospheric activity

    NASA Astrophysics Data System (ADS)

    Díaz, R. F.; González, J. F.; Cincunegui, C.; Mauas, P. J. D.

    2007-11-01

    Aims:We study the spectroscopic binary system Gl 375 to characterise its orbit and the spectral types and chromospheric activity levels of the components. Methods: We employed medium-resolution echelle spectra obtained at the 2.15 m telescope at the Argentinian observatory CASLEO and photometric observations obtained from the ASAS database. Results: We have separated the composite spectra into those corresponding to both components. The separated spectra allow us to confirm that the spectral types of both components are similar (dMe3.5) and to obtain precise measurements of the orbital period (P = 1.87844 days), minimum masses (M_1 sin3 i = 0.35 {M}_⊙ and M_2 sin3 i =0.33 {M}_⊙), and other orbital parameters. The photometric observations exhibit a sinusoidal variation with the same period as the orbital period. We interpreted this as signs of active regions carried along with rotation in a tidally synchronised system, and studied the evolution of the amplitude of the modulation on longer timescales. Together with the mean magnitude, the modulation exhibits a roughly cyclic variation with a period of around 800 days. This periodicity is also found in the flux of the Ca II K lines of both components, which seem to be in phase. Conclusions: The periodic changes in the three observables are interpreted as a sign of a stellar activity cycle. Both components appear to be in phase, which implies that they are magnetically connected. The measured cycle of ≈2.2 years (≈800 days) is consistent with previous determinations of activity cycles in similar stars. The authors are visiting astronomers of the Complejo Astronómico El Leoncito, operated under an agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the National Universities of La Plata, Córdoba, and San Juan.

  10. [Mini-laparoscopy vs. laparoscopy for the gallblader stone treatment. Prospective and comparative study].

    PubMed

    Lada, Paul Eduardo; Forez, Francisco; Janikov, Christian; Mariot, Daniela; Sanchez Tassone, Carlos; Massa, Martin

    2015-01-01

    Antecedentes: La colecistectomía por video-laparoscópica es considerada como el gold-standard del tratamiento de la colecistolitiasis. No obstante, en la literatura internacional sigue teniendo presencia las incisiones pequeñas adaptadas como procedimiento alternativo. Objetivos: El objetivo de este estudio es evaluar los resultados obtenidos con la video-laparoscopia (CVL) y las incisiones pequeñas adaptadas (IPA) en el tratamiento de la colecistolitiasis. Diseño: Prospectivo y comparativo protocolizado. Lugar de aplicación: Servicio de Cirugía General “Pablo Luis Mirizzi” del Hospital Nacional de Clínicas. Material y Métodos: Entre enero del 1994 y diciembre del 2011, hemos tratado quirúrgicamente 3822 pacientes con colélitiasis. En 1735 pacientes se práctico una CVL y en 2087 por IPA, configurando dos grupos, que en lo relacionado a la edad, sexo, operaciones previas y diagnóstico preoperatorio constituyen dos grupos comparables. Resultados: Ninguno de los procedimientos tuvo mortalidad. 115 casos (6,62%) fueron convertidos a cirugía abierta en la CVL. Las complicaciones postoperatorias quirúrgicas fueron del 2,40 % para la CVL y del 6,37 % para las IPA. Las causas de bilirragias fueron superiores y de mayor gravedad en la CVL, cuya incidencia fue del 0,55 % en contraposición del 0,23 % de los operados por IPA. Conclusiones: Sin duda en manos experimentadas la CVL constituye el procedimiento de elección o gold standard en el tratamiento de la colecistolitiasis. No obstante, sobretodo en ambientes o regiones con restricciones presupuestarias las IPA representa una excelente gold estándar alternativo, por ser un procedimiento seguro, muy económico y complejidad razonable con menor índice de lesiones quirúrgicas graves.

  11. [Zenker's diverticulum: election of surgical treatment and outcome. Case presentation].

    PubMed

    Segura-González, José Manuel Carlos; Espinosa-González, Omar; García-Cano, Eugenio; Sánchez-Córdova, Gabriela; Hernández-Ceballos, Javier Alonso

    2014-01-01

    Antecedentes: los divertículos de Zenker son protrusiones de la mucosa faríngea a través de una zona débil de su pared posterior. Es un padecimiento raro, con una incidencia en México de aproximadamente 0.04% de la población. El tratamiento indicado es quirúrgico. Caso clínico: paciente masculino de 67 años de edad, que 15 meses antes del diagnóstico experimentó síntomas de: disfagia a sólidos y ocasionalmente a líquidos, ahogo por las noches, sialorrea, halitosis, pérdida de 3 kg en dos meses y aumento del apetito. El diagnóstico se confirmó a través de métodos de imagen y endoscopia. Se realizó exitosamente una diverticulectomía con miotomía de músculo cricofaríngeo. Al tercer día de operado pudo ingerir líquidos sin complicaciones, y fue dado de alta al sexto día. Un año después no había mostrado recurrencias. Conclusión: los procedimientos de invasión mínima son útiles en pacientes con comorbilidades porque requieren corto tiempo de anestesia y de hospitalización. En este medio, el tratamiento abierto es la mejor técnica para su resolución, ya que la capacitación para efectuar procedimientos endoscópicos representa un problema por la falta de infraestructura y personal especializado.

  12. Clinical effects of a w3 enhanced powdered nutritional formula in postsurgical ambulatory head and neck cancer patients.

    PubMed

    de Luis, D A; Izaola, O; Cuellar, L; Terroba, M C; Ventosa, M; Martin, T; Aller, R

    2013-01-01

    Antecedentes: Los pacientes con tumores de cabeza y cuello sometidos a cirugía presentan un alto riesgo de complicaciones nutricionales. Objetivo: El principal objetivo de nuestro trabajo fue evaluar la influencia de un suplemento oral en polvo inmunoenriquecido con ácidos grasos omega 3 en pacientes postquirúrgicos ambulatorios con tumores de cabeza y cuello. Diseño: Una muestra de 33 pacientes postquirúrgicos ambulatorios con tumores de cabeza y cuello fue evaluada. Tras el alta hospitalaria, los pacientes recibieron dos envases al día de un suplemento inmunoenriquecido con omega 3 en polvo durante 12 semanas. Resultados: La edad media fue de 61,3 ± 9,1 años (6 mujeres/27 varones). La duración media de la suplementación fue de 95,9 ± 21,1 días. Se detectó un aumento significativo en los niveles de albúmina y transferrina en los pacientes del grupo global, en los que recibieron radioterapia y en los que no al recibieron. El peso y los parámetros antropométricos no mejoraron en el grupo global ni en los que recibieron radioterapia. Sin embargo los pacientes que no recibieron radioterapia tuvieron un aumento de la masa magra, peso y masa grasa Conclusiones: A la dosis usada, la formula en polvo enriquecida en omega 3 mejoró lo niveles de proteínas séricas. Por otra parte los pacientes que no recibieron radioterapia durante el seguimiento presentaron un aumento del peso, masa grasa y masa magra.

  13. [Total knee and hip prosthesis: variables associated with costs].

    PubMed

    Herrera-Espiñeira, Carmen; Escobar, Antonio; Navarro-Espigares, José Luis; Castillo, Juan de Dios Lunadel; García-Pérez, Lidia; Godoy-Montijano, Amparo

    2013-01-01

    antecedentes: la alta prevalencia de artrosis en los países occidentales, el elevado costo de las intervenciones de artroplastia de cadera y rodilla y las amplias variaciones en la práctica médica generan gran interés por comparar los costos asociados antes y después de la cirugía. Objetivo: conocer el costo de las intervenciones de reemplazo total de cadera y rodilla durante la estancia hospitalaria y al año de seguimiento posterior al alta. material y métodos: estudio multicéntrico y prospectivo efectuado en 15 hospitales de tres comunidades autónomas. La relación entre las variables independientes con el costo de la estancia y costo post-alta, se analizó con modelos multinivel y para agrupar los casos se utilizó la variable "hospital." Las variables independientes fueron: edad, sexo, índice de masa corporal, calidad de vida prequirúrgica (cuestionarios ED-5D, SF-12 y Womac), intervención (cadera-rodilla), índice Charlson, complicaciones, número de camas y dependencia económico-institucional del hospital, comunidad autó-noma y presencia de cuidador. Resultados: el costo promedio por paciente, sin incluir el costo de la prótesis, fue de 4,734 Euros ± 2,136 y el costo del seguimiento post alta de 554 Euros ± 509. Si se incluye el costo de la prótesis, al final del año el costo total asciende a 7,645 Euros ± 2,248. Conclusiones: existe un margen considerable en la reducción de los costos de estancia; más de 44% de la variabilidad observada no está determinada por las condiciones clínicas de los pacientes sino por el comportamiento de los centros hospitalarios.

  14. [Traumatic spinal cord injury in children and adolescents in Asturias].

    PubMed

    Álvarez-Pérez, M José; López-Llano, M Luisa

    2015-05-01

    Introduccion. La lesion medular traumatica es rara en la infancia, pero con graves complicaciones. Objetivo. Conocer la incidencia, etiologia y caracteristicas sociodemograficas de los pacientes pediatricos y adolescentes con lesion medular traumatica en Asturias. Pacientes y metodos. Censo de pacientes entre 0-17 años codificados como 'lesion medular traumatica con o sin fractura vertebral' en Asturias entre 1934 y 2013. Se recogen variables sociodemograficas, hospitalarias y clinicas. Resultados. Se registran 72 pacientes, la mayoria varones (79,2%), con una edad media de 16 años (rango: 5-17 años). La incidencia en 2011 fue de 7,3 por millon. Predominaron las lesiones completas (68,1%) y la localizacion dorsal (44,4%). Hubo lesion osea en el 95,8%, y en la mitad de ellos, afectacion de dos o mas vertebras. La etiologia predominante fueron los accidentes de trafico (52,1%), sobre todo de vehiculos de cuatro ruedas (63,4%), con una mayoria de varones con una edad media de 17 años y una localizacion dorsal (46,3%). En segundo y tercer lugar se situaron la etiologia laboral y la deportiva, con el mismo numero de casos. En la laboral predominaron los varones y el nivel toracico (77,8%), y el mecanismo fundamental fue el golpe directo. En la deportiva, la mayoria fueron varones, y la zambullida fue la causa mas importante, de predominio cervical. Conclusiones. Son necesarios estudios centrados en este grupo poblacional que permitan determinar sus caracteristicas diferenciadoras para establecer programas de cuidados adaptados a sus necesidades, asi como las medidas preventivas mas oportunas para reducir las posibilidades de una lesion con tan graves repercusiones.

  15. [Endogenous Candida dubliniensis endophtalmitis. First case in Mexico].

    PubMed

    Gittins-Núñez, Luis Othon; Hernández-Núñez, Fabiola

    2015-01-01

    Introducción: los casos de endoftalmitis por Candida se relacionan con estados de inmunodepresión, catéteres intravenosos, procedimientos invasivos y alimentación parenteral. Se estima que entre el 2 % y el 10 % de las endoftalmitis son endógenas. Dentro de la etiología fúngica, Candida albicans es el microorganismo más frecuentemente aislado. La infección por C. dubliniensis se reporta en menos del 2 % de los casos de infección por Candida a nivel sistémico y hay pocos casos reportados de endoftalmitis. La presentación clínica consiste en baja visual, vitreítis, depósitos algodonosos, coriorretinitis y necrosis retiniana. El diagnóstico confirmatorio se debe realizar con cultivo vítreo y el tratamiento se basa en la combinación de antifúngicos intravítreos y vitrectomía. Caso clínico: se trata paciente con fistula enterocutánea larga estancia intrahospitalaria con NPT que cursa con endoftalmitis bilateral sin inmunodepresión. Conclusiones: la endoftalmitis por Candida siempre debe tomarse en cuenta en pacientes con factores de riesgo para poder brindar un diagnóstico oportuno y un adecuado manejo. Aun así, el pronóstico en estos pacientes es malo para la función, la conservación del órgano y para la vida debido a las complicaciones por patologías asociadas.

  16. [Children hospitalized with influenza A H1N1. The field of private care during the pandemic in Mexico].

    PubMed

    Iglesias-Leboreiro, José; Rendón-Macías, Mario Enrique; Marín-Romero, Margarito; Bernárdez-Zapata, Isabel; Del Carmen López-Enríquez, Claudia

    2013-01-01

    Introducción: la pandemia de influenza A H1N1 en México generó gran preocupación por su potencial alta letalidad. El objetivo de esta investigación fue analizar las características y evolución de los pacientes pediátricos atendidos en un hospital privado. Métodos: se incluyeron todos los casos hospitalizados de abril de 2009 a marzo de 2010 con diagnóstico confirmado de influenza A H1N1 por medio de RT-PCR. Se analizaron los datos clínicos, radiológicos y tratamiento de los pacientes. Se determinaron días de estancia, muerte y necesidad de cuidados intensivos. Resultados: fueron hospitalizados 50 niños, 15 menores de tres años de edad (30 %), 23 de tres a cinco años (46 %) y 12 mayores de cinco años (24 %). Ninguno ameritó cuidados en terapia intensiva y no hubo defunciones; 86 % ingresó por fiebre y 40 % con dificultad respiratoria de leve a moderada. En 10 hubo evidencia radiológica de neumonía intersticial, en cuatro de condensación pulmonar y en seis de obstrucción aérea. Todos fueron tratados con oseltamivir y cuatro con antibióticos. La estancia media hospitalaria fue de 48 horas. Todos se egresaron sin complicaciones. Conclusiones: la evolución de los pacientes hospitalizados fue benigna.

  17. [The relationship between placental lesions and early hemorrhagic-ischemic cerebral injury in very low birth weight infants].

    PubMed

    Vaihinger, Mara; Mazzitelli, Nancy; Balanian, Nora; Grandi, Carlos

    2013-01-01

    Introducción: El examen histopatológico de la placenta es trascendente para evidenciar desordenes relacionados con el embarazo que se asocian a lesiones isquémico hemorrágicas cerebrales (LIHC) en recién nacidos prematuros (RNPT). Objetivo: Estudiar la asociación entre lesiones placentarias y LIHC precoces detectadas con ecografía en RNPT ≤ 1500 g y 32 semanas. Material y Métodos: diseño caso – control. Criterios de inclusión: RNPT ≥ 24 y ≤ 32 semanas, ≥ 500 y ≤ 1500 g, nacidos en la Maternidad Sardá entre años 2006 y 2012. Criterios de exclusión: RNPT gemelares, con malformaciones o infecciones intrauterinas específicas y los fallecidos antes de las 24 horas de vida. Resultados: fueron incluidos 198 RNPT, 49 con LIHC (casos) y 149 sin LIHC (controles). No se encontraron diferencias en las lesiones histopatológicas placentarias entre los dos grupos, aunque se apreció una clara tendencia de lesiones inflamatorias en los casos (67.3%) en comparación con los controles (48 %, p = 0.018). La ruptura prematura de las membranas (p = 0.027) y la corioamnionitis clínica fueron más frecuentes en los casos. Complicaciones fuertemente asociadas a prematurez fueron estadísticamente más evidentes entre los casos. La hemorragia intraventricular fue la lesión cerebral más hallada. El 50% de los casos persistieron con LIHC a las 36-40 semanas, mientras que a mayor edad gestacional el riesgo de LIHC fue menor . Conclusiones: las lesiones histopatológicas placentarias no estuvieron asociadas independientemente a mayor riesgo de LIHC, aunque se observó un predominio de lesiones inflamatorias en los casos.

  18. Que Tal la Justicia Social en los Alumnos de la UIA (Universidad Iberoamericana)? Investigacion sobre los Logros en la Formacion Valoral (What about Social Justice among the Students of the Iberoamerican University? Survey on the Achievements in the Acquisition of Values).

    ERIC Educational Resources Information Center

    Bazdresch Parada, Juan E.

    This survey investigates how the students of social philosophy modify their criteria on basic questions of social justice. A questionnaire of 30 questions, with 5 options, was developed. The five answer/options correspond to the following five schools of social philosophy (five ways of thinking): (1) liberal individualism; (2) humanitarianism; (3)…

  19. Hispanic Youth--Dropout Prevention. Report of the Task Force on the Participation of Hispanic Students in Vocational Education Programs = La Joventud Hispana. Reporte del Grupo Especial. La Investigacion de la Participacion de los Estudiantes Hispanos en la Educacion Relativa a la Vocacion.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    An Idaho task force of Hispanic Americans, industry representatives, and education leaders studied the reasons Hispanic students were not enrolling in and completing vocational education programs. The task force sponsored a series of community meetings to identify reasons and solutions. Approximately 40-60 parents, students, and other interested…

  20. Construyendo un Puente entre la Educacion del Dotado y el Mejoramiento Escolar Integral. Resumen. La Serie de Decision Basada en la Investigacion (Building a Bridge between Gifted Education and Total School Improvement. Summary. Talent Development Research-Based Decision Making Series).

    ERIC Educational Resources Information Center

    Renzulli, Joseph S.

    This monograph addresses the role of gifted education in total school improvement by describing three service delivery components (the Total Talent Portfolio, Curriculum Modification Techniques, and Enrichment Learning and Teaching) and several organizational components of the Schoolwide Enrichment Model (SEM). The report describes how the SEM can…

  1. El juego entre el nacimiento y los 7 anos: Un manual para ludotecarias. Investigacion-accion sobre la Familia y la Primera Infancia. UNESCO Sector de Educacion Monografia (Play between Birth and 7 Years: A Manual for Preschool Teachers. Action Research in Family and Early Childhood. UNESCO Education Sector Monograph).

    ERIC Educational Resources Information Center

    Grellet, Carolina

    The purpose of this Spanish-language manual is to help preschool teachers better understand theoretical concepts related to children's play. Following a preface that discusses UNESCO's activities related to early childhood education, the two main sections of the manual discuss children's play between 0-2 years and 2-7 years. Each section includes…

  2. Consulta regional sobre investigacion en educacion y toma de decisiones en America Latina: Informe final (Lima, Peru, 11-15 de mayo de 1987) (Regional Meeting on Research in Education and Decision Making in Latin America: Final Report [Lima, Peru, May 11-15, 1987]).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Santiago (Chile). Regional Office for Education in Latin America and the Caribbean.

    This report presents the highlights of a United Nations Educational, Scientific, and Cultural Organization (UNESCO) conference that was convened to give impetus to and encourage research programs, to analyze research policy formation, and to establish research priorities in the field of educational planning and administration. The document…

  3. Órbitas caóticas en satelites galácticos

    NASA Astrophysics Data System (ADS)

    Carpintero, D. D.; Muzzio, J. C.; Vergne, M. M.; Wachlin, F. C.

    En trabajos anteriores investigamos las órbitas de estrellas que forman los satelites galácticos utilizando análisis de frecuencias. Su uso estaba plenamente justificado por su velocidad y la gran información que brinda, amén de haber dado resultados muy concordantes con los exponentes de Liapunov. Sin embargo, más recientemente, encontramos algunos problemas en la utilización del análisis de frecuencias en sistemas de referencia rotantes (como se utilizan para los satélites), por lo que en este trabajo rehicimos nuestras investigaciones previas utilizando exclusivamente exponentes de Liapunov. Algunas conclusiones anteriores se han confirmado, en tanto que otras deben modificarse. Además, los nuevos resultados muestran que las escalas de tiempo de los procesos caóticos en los satélites galácticos son comparables a, o más cortas que, las escalas de tiempo de otros procesos dinámicos característicos de estos objetos.

  4. [Glucagon-like peptide-1 (GLP-1) mimetics: a new treatment for Alzheimer's disease?].

    PubMed

    García-Casares, Natalia; García-Arnés, Juan Antonio; Gómez-Huelgas, Ricardo; Valdivielso-Felices, Pedro; García-Arias, Carlota; González-Santos, Pedro

    2014-12-01

    Introduccion. Los analogos del glucagon-like peptide-1 (GLP-1) son una opcion terapeutica establecida en los pacientes con diabetes tipo 2. Sin embargo, las propiedades de los analogos del GLP-1 van mas alla del control estrictamente metabolico del paciente diabetico. Los efectos neuroprotectores de los analogos del GLP-1 se han puesto de manifiesto en estudios recientes y han abierto nuevos campos de investigacion en trastornos neurodegenerativos como la enfermedad de Alzheimer (EA), entre otros. Objetivo. Revision sistematica de los estudios experimentales y ensayos clinicos en humanos que demuestran las propiedades neuroprotectoras de los analogos del GLP-1 en la EA. Desarrollo. Los estudios experimentales que se han llevado a cabo en modelos de roedores con EA demuestran las propiedades neuroprotectoras de los analogos del GLP-1 sobre el sistema nervioso central que reducen las placas de beta-amiloide, el estres oxidativo y la respuesta inflamatoria cerebral. Recientemente se han puesto en marcha estudios con analogos del GLP-1 en humanos con deterioro cognitivo y EA. Conclusiones. Los analogos del GLP-1 presentan propiedades neuroprotectoras. Al considerarse la diabetes tipo 2 un factor de riesgo para el deterioro cognitivo y la demencia, deben considerarse los beneficios de los analogos del GLP-1 sobre la cognicion. Del mismo modo, los analogos del GLP-1 suponen un tratamiento prometedor en la EA.

  5. Cerebral networks of sustained attention and working memory: a functional magnetic resonance imaging study based on the Continuous Performance Test.

    PubMed

    Bartés-Serrallonga, M; Adan, A; Solé-Casals, J; Caldú, X; Falcón, C; Pérez-Pàmies, M; Bargalló, N; Serra-Grabulosa, J M

    2014-04-01

    Introduccion. Uno de los paradigmas mas utilizados en el estudio de la atencion es el Continuous Performance Test (CPT). La version de pares identicos (CPT-IP) se ha utilizado ampliamente para evaluar los deficits de atencion en los trastornos del neurodesarrollo, neurologicos y psiquiatricos. Sin embargo, la localizacion de la activacion cerebral de las redes atencionales varia significativamente segun el diseño de resonancia magnetica funcional (RMf) usado. Objetivo. Diseñar una tarea para evaluar la atencion sostenida y la memoria de trabajo mediante RMf para proporcionar datos de investigacion relacionados con la localizacion y el papel de estas funciones. Sujetos y metodos. El estudio conto con la participacion de 40 estudiantes, todos ellos diestros (50%, mujeres; rango: 18-25 años). La tarea de CPT-IP se diseño como una tarea de bloques, en la que se combinaban los periodos CPT-IP con los de reposo. Resultados. La tarea de CPT-IP utilizada activa una red formada por regiones frontales, parietales y occipitales, y estas se relacionan con funciones ejecutivas y atencionales. Conclusiones. La tarea de CPT-IP utilizada en nuestro trabajo proporciona datos normativos en adultos sanos para el estudio del sustrato neural de la atencion sostenida y la memoria de trabajo. Estos datos podrian ser utiles para evaluar trastornos que cursan con deficits en memoria de trabajo y en atencion sostenida.

  6. [The essence of essential tremor: neurochemical bases].

    PubMed

    Gironell, A; Marin-Lahoz, J

    2016-06-01

    Introduccion. El temblor esencial es el trastorno del movimiento mas frecuente en el adulto. Se ha considerado una enfermedad benigna, pero puede ocasionar una importante discapacidad fisica y psicosocial. El tratamiento farmacologico sigue siendo poco satisfactorio. Su etiologia, fisiopatologia y anatomia siguen sin conocerse del todo. Objetivo. El conocimiento de las bases neuroquimicas es fundamental para el desarrollo de terapias mas eficaces. Se revisan los conocimientos actuales en este campo a fin de incentivar nuevas investigaciones e ideas que permitan mejorar la comprension de la enfermedad y que fomenten el desarrollo de nuevas terapias farmacologicas. Desarrollo. Se revisan los trabajos realizados hasta la fecha en humanos y en modelos animales de neurotransmisores (acido gamma-aminobutirico, glutamato, noradrenalina, serotonina, adenosina), proteinas y otros fenomenos neuroquimicos, como los canales de calcio de tipo T en el temblor esencial. Conclusiones. Se han descrito cuatro disfunciones neuroquimicas que acontecerian basicamente en el cerebelo y el nucleo olivar inferior: alteracion del sistema gabergico, aumento del rebote postinhibitorio mediante corrientes de calcio de tipo T, disminucion de los mecanismos de inhibicion neuronal y aumento de la actividad de los neurotransmisores excitatorios. Estas disfunciones neuroquimicas comportarian un aumento de la actividad de las neuronas profundas cerebelosas con actividad oscilatoria, que se trasladaria al nucleo del talamo y a la corteza motora, y comportarian la aparicion del temblor. Son necesarios nuevos estudios para poder confirmar estas hipotesis y seguir avanzando para conseguir tratamientos farmacologicos mas eficaces para los pacientes con temblor esencial.

  7. [Factors associated to the work situation of patients with multiple sclerosis].

    PubMed

    Cores, Evangelina V; Vanotti, Sandra; Burin, Débora I; Politis, Daniel G; Villa, Andrés

    2014-02-16

    Introduccion. La esclerosis multiple es una enfermedad neurologica desmielinizante que suele provocar trastornos motrices, perceptivos, afectivos y cognitivos a quienes la padecen. Estos sintomas pueden llevar a la persona a perder su empleo, y disminuir la calidad de vida del paciente y sus familiares. Objetivo. Revisar estudios sobre variables demograficas, clinicas, cognitivas, psiquiatricas, laborales y sociales asociadas con la situacion laboral. Desarrollo. Estudios transversales y longitudinales han detectado variables relacionadas con el desempleo. Las investigaciones empiricas muestran una influencia clara de la discapacidad fisica, la fatiga y el curso de la enfermedad sobre la situacion laboral. Sin embargo, el genero, la depresion, la edad, la duracion de la enfermedad y las variables cognitivas no poseen el mismo grado de evidencia. Caracteristicas de la ocupacion, como discriminacion laboral, actitud del empleador, leyes laborales, actitud de los compañeros de trabajo y dificultades en el transporte han sido variables poco consideradas. Conclusiones. Muchos de los factores que determinan la perdida de empleo en un paciente con esclerosis multiple pueden identificarse a tiempo para poder modificarlos o compensarlos. Los conocimientos aportados por los estudios reseñados permiten detectar a aquellos pacientes que se encuentran en riesgo de perder su empleo para realizar intervenciones posibles con el objetivo de prevenir esta situacion. En particular, el perfil de vulnerabilidad incluye alta discapacidad fisica y fatiga, curso progresivo de la enfermedad y presencia de deterioro cognitivo, entre otros.

  8. [Erythropoietin as a protective factor in rat CNS cells receiving radiotherapy -an in vitro study].

    PubMed

    Gomez-De la Riva, Álvaro; Isla-Guerrero, Alberto; García-Grande, Antonio

    2014-03-01

    Objetivo. Investigar el efecto de la eritropoyetina en cultivos celulares de corteza cerebral de ratas cuando se administra radioterapia. Materiales y metodos. El estudio se desarrolla con la obtencion de corteza cerebral de embriones de 17 dias de preñez de ratas Wistar. Las celulas cultivadas despues de 72 horas de la extraccion de la corteza se dividieron en dos grupos, a uno de ellos se le administro eritropoyetina alfa a una concentracion de 30 pM y el otro era el grupo control. A los dos grupos de celulas se les radio con 6 Gy mediante un aparato Phoenix. Tras la radioterapia permanecieron 24 horas en la incubadora antes de fijarlas. Las celulas fueron fijadas con formaldehido al 4%. A continuacion, con la tecnica de TUNEL, se valoro el numero de celulas apoptoticas en los cultivos radiados. Resultados. Se observo un porcentaje de apoptosis del 25,22% del grupo de cultivo sin eritropoyetina, mientras que en el grupo de celulas radiadas con eritropoyetina fue del 15,5%. Las variables cuantitativas se analizaron mediante el test t de Student y el resultado de la comparacion entre los dos grupos fue estadisticamente significativo (p < 0,0001). Conclusion. En nuestro modelo experimental in vitro se comprobo que la eritropoyetina es eficaz en la prevencion de la apoptosis en celulas del sistema nervioso central de ratas por radiacion. Esto abre nuevos campos para la investigacion del efecto protector del sistema nervioso.

  9. Predictive coupled-cluster isomer orderings for some SinCm (m, n ≤ 12) clusters: A pragmatic comparison between DFT and complete basis limit coupled-cluster benchmarks

    NASA Astrophysics Data System (ADS)

    Byrd, Jason N.; Lutz, Jesse J.; Jin, Yifan; Ranasinghe, Duminda S.; Montgomery, John A.; Perera, Ajith; Duan, Xiaofeng F.; Burggraf, Larry W.; Sanders, Beverly A.; Bartlett, Rodney J.

    2016-07-01

    The accurate determination of the preferred Si12C12 isomer is important to guide experimental efforts directed towards synthesizing SiC nano-wires and related polymer structures which are anticipated to be highly efficient exciton materials for the opto-electronic devices. In order to definitively identify preferred isomeric structures for silicon carbon nano-clusters, highly accurate geometries, energies, and harmonic zero point energies have been computed using coupled-cluster theory with systematic extrapolation to the complete basis limit for set of silicon carbon clusters ranging in size from SiC3 to Si12C12. It is found that post-MBPT(2) correlation energy plays a significant role in obtaining converged relative isomer energies, suggesting that predictions using low rung density functional methods will not have adequate accuracy. Utilizing the best composite coupled-cluster energy that is still computationally feasible, entailing a 3-4 SCF and coupled-cluster theory with singles and doubles extrapolation with triple-ζ (T) correlation, the closo Si12C12 isomer is identified to be the preferred isomer in the support of previous calculations [X. F. Duan and L. W. Burggraf, J. Chem. Phys. 142, 034303 (2015)]. Additionally we have investigated more pragmatic approaches to obtaining accurate silicon carbide isomer energies, including the use of frozen natural orbital coupled-cluster theory and several rungs of standard and double-hybrid density functional theory. Frozen natural orbitals as a way to compute post-MBPT(2) correlation energy are found to be an excellent balance between efficiency and accuracy.

  10. Fields without Borders: An Anthology of Documentary Writing and Photography by Student Action with Farmworkers' Interns = Campos sin Fronteras: Una Antologia de Obras Escritas y Fotografia por Estudiantes Internos de Accion Estudiantil con Trabajadores Agricolas.

    ERIC Educational Resources Information Center

    Manly, Libby, Ed.; Okie, Alejandra, Ed.; Wiggins, Melinda, Ed.

    In this booklet, essays and poems, presented both in English and in Spanish, portray the feelings, conditions, and economic plight of migrant and seasonal farmworkers in North and South Carolina, often in their own words. A preface describes Student Action with Farmworkers summer internships in which college students spend 10 weeks working with…

  11. Predictive coupled-cluster isomer orderings for some SinCm (m, n ≤ 12) clusters: A pragmatic comparison between DFT and complete basis limit coupled-cluster benchmarks.

    PubMed

    Byrd, Jason N; Lutz, Jesse J; Jin, Yifan; Ranasinghe, Duminda S; Montgomery, John A; Perera, Ajith; Duan, Xiaofeng F; Burggraf, Larry W; Sanders, Beverly A; Bartlett, Rodney J

    2016-07-14

    The accurate determination of the preferred Si12C12 isomer is important to guide experimental efforts directed towards synthesizing SiC nano-wires and related polymer structures which are anticipated to be highly efficient exciton materials for the opto-electronic devices. In order to definitively identify preferred isomeric structures for silicon carbon nano-clusters, highly accurate geometries, energies, and harmonic zero point energies have been computed using coupled-cluster theory with systematic extrapolation to the complete basis limit for set of silicon carbon clusters ranging in size from SiC3 to Si12C12. It is found that post-MBPT(2) correlation energy plays a significant role in obtaining converged relative isomer energies, suggesting that predictions using low rung density functional methods will not have adequate accuracy. Utilizing the best composite coupled-cluster energy that is still computationally feasible, entailing a 3-4 SCF and coupled-cluster theory with singles and doubles extrapolation with triple-ζ (T) correlation, the closo Si12C12 isomer is identified to be the preferred isomer in the support of previous calculations [X. F. Duan and L. W. Burggraf, J. Chem. Phys. 142, 034303 (2015)]. Additionally we have investigated more pragmatic approaches to obtaining accurate silicon carbide isomer energies, including the use of frozen natural orbital coupled-cluster theory and several rungs of standard and double-hybrid density functional theory. Frozen natural orbitals as a way to compute post-MBPT(2) correlation energy are found to be an excellent balance between efficiency and accuracy. PMID:27421410

  12. Improved Semipolar (112¯2) GaN Quality Grown on m-Plane Sapphire Substrates by Metal Organic Chemical Vapor Deposition Using Self-Organized SiN x Interlayer

    NASA Astrophysics Data System (ADS)

    Sheng-Rui, Xu; Ying, Zhao; Teng, Jiang; Jin-Cheng, Zhang; Pei-Xian, Li; Yue, Hao

    2016-06-01

    Not Available Supported by the National Natural Science Foundation of China under Grant Nos 61204006 and 61574108, the Fundamental Research Funds for the Central Universities under Grant No JB141101, and the Foundation of Key Laboratory of Nanodevices and Applications of Suzhou Institute of Nano-Tech and Nano-Bionics of Chinese Academy of Sciences under Grant No 15CS01.

  13. 'At times, I feel like I'm sinning': the paradoxical role of non-lesbian, gay, bisexual and transgender-affirming religion in the lives of behaviourally-bisexual Latino men.

    PubMed

    Severson, Nicolette; Muñoz-Laboy, Miguel; Kaufman, Rebecca

    2014-01-01

    In this paper, we examine non-lesbian, gay, bisexual and transgender-affirming religiosity among behaviourally-bisexual Latino men as it relates to sexual attitudes, experiences and behaviours. We asked how does religiosity correspond to masculine identities, sex roles and condom efficacy? And how might religiosity influence contexts of health risks? Data were analysed from a mixed-methods study of 142 behaviourally-bisexual Latino men, aged 18-60 years. Major findings include positive correlations between religiosity and (1) masculine ideologies, (2) internalised homonegativity, (3) less comfort with receptive sex, (4) low condom efficacy and (5) higher levels of loneliness and incidents of discriminatory events. Results are paired with illustrative, descriptive case studies from life history interviews. It is suggested that non-lesbian, gay, bisexual and transgender-affirming religiosity plays a paradoxical role in the lives of behaviourally-bisexual Latino men - on one hand, increasing internalised homonegativity and attendant health risks and, on the other, providing social support to members of a marginalised population.

  14. Predictive coupled-cluster isomer orderings for some SinCm (m, n ≤ 12) clusters: A pragmatic comparison between DFT and complete basis limit coupled-cluster benchmarks.

    PubMed

    Byrd, Jason N; Lutz, Jesse J; Jin, Yifan; Ranasinghe, Duminda S; Montgomery, John A; Perera, Ajith; Duan, Xiaofeng F; Burggraf, Larry W; Sanders, Beverly A; Bartlett, Rodney J

    2016-07-14

    The accurate determination of the preferred Si12C12 isomer is important to guide experimental efforts directed towards synthesizing SiC nano-wires and related polymer structures which are anticipated to be highly efficient exciton materials for the opto-electronic devices. In order to definitively identify preferred isomeric structures for silicon carbon nano-clusters, highly accurate geometries, energies, and harmonic zero point energies have been computed using coupled-cluster theory with systematic extrapolation to the complete basis limit for set of silicon carbon clusters ranging in size from SiC3 to Si12C12. It is found that post-MBPT(2) correlation energy plays a significant role in obtaining converged relative isomer energies, suggesting that predictions using low rung density functional methods will not have adequate accuracy. Utilizing the best composite coupled-cluster energy that is still computationally feasible, entailing a 3-4 SCF and coupled-cluster theory with singles and doubles extrapolation with triple-ζ (T) correlation, the closo Si12C12 isomer is identified to be the preferred isomer in the support of previous calculations [X. F. Duan and L. W. Burggraf, J. Chem. Phys. 142, 034303 (2015)]. Additionally we have investigated more pragmatic approaches to obtaining accurate silicon carbide isomer energies, including the use of frozen natural orbital coupled-cluster theory and several rungs of standard and double-hybrid density functional theory. Frozen natural orbitals as a way to compute post-MBPT(2) correlation energy are found to be an excellent balance between efficiency and accuracy.

  15. Taiwan Earthquake Damage Index Sin Mei Nga* and Masataka Andob a* Department of Geology, Chinese Culture University, No. 55, Hwa-Kang Road, Yang-Ming-Shan, Taipei 11114, Taiwan b Institute of Earth Sciences, Academia Sinica, 128, Sec2, Academia Road, Nangang, Taipei 11529, Taiwan * Corresponding author. Tel.: +886 (02) 28 61 05 11 ext.26133 fax: +886 (02) 28 61 49 59 E-mail: wsw2@ulive.pccu.edu.tw or sin_mei_josephine_ng@hotmail.com

    NASA Astrophysics Data System (ADS)

    Ng, S.

    2012-12-01

    Taking advantage of a previous study and twelve-year, free-field strong motion data in Taiwan, a preliminary, five-level earthquake damage index is newly proposed: I-No (no damage), II-Very Light, III-Light, IV-Moderate, and V-Heavy. For index I, PGA and PGV are, respectively, <62.5 gal and <11 cm/s. Likewise, for index II, PGA is ≧62.5 and ≦187.5 gal; but, PGV is ≧11 and ≦35 cm/s. Similarly, PGA is ≧187.5 and ≦325 gal; but, PGV is ≧35 and ≦55 cm/s for index III. The corresponding PGA and PGV, for index IV, are ≧325 and ≦450 gal and ≧55 and ≦75 cm/s. Finally, for index V, PGA and PGV are respectively >450 gal and >75 cm/s. Ten damaging seismic events in the past twelve years are redefined using this new earthquake damage index, with the devastating Chi-Chi earthquake and one non-damaging event as reference earthquakes. This newly proposed index depicts seismic hazard of these earthquakes with higher accuracy when compared to the existing intensity scale in Taiwan region. For further analysis, Japan earthquakes are also plotted as references.

  16. [In Process Citation].

    PubMed

    Sánchez-Ramírez, Carmen A; Larrosa-Haro, Alfredo; M Vásquez Garibay, Edgar; Rodríguez-Anguiano, Ana K; Cámara-López, María E

    2016-02-16

    Introducción: la ingestión de cáusticos (IC) en niños y adolescentes puede ocasionar esofagitis erosiva, estenosis esofágica y disfagia, entidades que pueden alterar el proceso de alimentación y originar desnutrición y retraso en el crecimiento.Objetivos: evaluar el estado nutricio de niños con IC y su asociación con disfagia y estenosis esofágica.Métodos: estudio transversal analítico en el que se incluyó a 62 niños atendidos en un hospital pediátrico de referencia que sufrieron IC. Lasvariables independientes fueron la presencia/ausencia de disfagia y/o estenosis esofágica; las dependientes fueron el crecimiento y el estado nutricio evaluados mediante antropometría. Análisis estadístico: c2, OR, IC 95%, kappa y t de Student.Resultados: la edad promedio fue 39,7 meses, el 39,7% eran niñas. Cuarenta y dos (77,8%) presentaron esofagitis erosiva (II-b, III-a, and III-b) en la endoscopia. En 24 (38,7%) ocurrió disfagia y en 40 (64,5%) estenosis esofágica. El puntaje z de la talla para la edad fue <-2 DE en cinco niños (8,1%) y el puntaje z del IMC < -2 DE en tres (4,8%). En 24.2% la z-IMC fue > +1 DE. El puntaje z de los indicadores del brazo relacionados a reservas grasa y masa muscular tanto en el grupo de estenosis como de disfagia se localizó en el lado negativo de la curva y ambos fueron significativamente menores a los del grupo sin disfagia o estenosis.Conclusiones: la proporción de esofagitis erosiva, estenosis o disfagia fue elevada. En los niños con disfagia o estenosis esofágica se identificaron reservas de grasa y masa muscular menores a las de los niños sin estas complicaciones.

  17. [Costs of appendicitis treatment by diagnosis-related groups in a third-level pediatric hospital].

    PubMed

    Tlacuilo-Parra, Alberto; Hernández-Hernández, Araceli; Venegas-Dávalos, Martha; Gutiérrez-Hermosillo, Violeta; Guevara-Gutiérrez, Elizabeth; Ambriz-González, Gabriela

    2014-01-01

    Antecedentes: los grupos relacionados con el diagnóstico se utilizan ampliamente en Europa; permiten comparar el desempeño de los hospitales y facilitan el sistema de pago hospitalario. Objetivo: clasificar mediante grupos relacionados con el diagnóstico a los niños operados por apendicitis en un hospital de tercer nivel de atención. Material y métodos: estudio transversal. Se analizaron: comorbilidad, tiempo de hospitalización, histología de la apendicitis y clasificación mediante grupos relacionados con el diagnóstico. Resultados: se incluyeron 313 pacientes, 62% hombres, con edad promedio de 8 ± 3 años, 91% llegaron referidos de otra unidad. Recibieron atención en el turno nocturno 67%, y permanecieron hospitalizados durante 4 ± 3 días. Hubo comorbilidad en 8% y complicaciones quirúrgicas en 11%. La apendicitis fue: edematosa en 11%, supurada en 36%, gangrenada en 22%, perforada en 29% y abscedada en 2%. La condición de egreso fue: con mejoría en 97%. El gasto total del grupo relacionado con el diagnóstico 343 fue 10,470,173 pesos, del grupo relacionado con el diagnóstico 342 de 1,227,592 pesos, y del grupo relacionado con el diagnóstico 340 de 511,521 pesos, lo que sumó 12,209,286 pesos mexicanos. Conclusión: el costo unitario del tratamiento de la apendicitis correspondiente al grupo relacionado con el diagnóstico 343 fue de 37,935 pesos, del grupo relacionado con el diagnóstico 342 de 49,103 pesos y del grupo relacionado con el diagnóstico 340 de 42,626 pesos. Puesto que 88% de los casos de apendicitis ocurrieron sin diagnóstico principal complicado, esos pacientes se podrían haber intervenido en un segundo nivel de atención, utilizando el reembolso obtenido del monto 343, sin necesidad de generar gastos adicionales.

  18. [In Process Citation].

    PubMed

    Sánchez-Ramírez, Carmen A; Larrosa-Haro, Alfredo; M Vásquez Garibay, Edgar; Rodríguez-Anguiano, Ana K; Cámara-López, María E

    2016-01-01

    Introducción: la ingestión de cáusticos (IC) en niños y adolescentes puede ocasionar esofagitis erosiva, estenosis esofágica y disfagia, entidades que pueden alterar el proceso de alimentación y originar desnutrición y retraso en el crecimiento.Objetivos: evaluar el estado nutricio de niños con IC y su asociación con disfagia y estenosis esofágica.Métodos: estudio transversal analítico en el que se incluyó a 62 niños atendidos en un hospital pediátrico de referencia que sufrieron IC. Lasvariables independientes fueron la presencia/ausencia de disfagia y/o estenosis esofágica; las dependientes fueron el crecimiento y el estado nutricio evaluados mediante antropometría. Análisis estadístico: c2, OR, IC 95%, kappa y t de Student.Resultados: la edad promedio fue 39,7 meses, el 39,7% eran niñas. Cuarenta y dos (77,8%) presentaron esofagitis erosiva (II-b, III-a, and III-b) en la endoscopia. En 24 (38,7%) ocurrió disfagia y en 40 (64,5%) estenosis esofágica. El puntaje z de la talla para la edad fue <-2 DE en cinco niños (8,1%) y el puntaje z del IMC < -2 DE en tres (4,8%). En 24.2% la z-IMC fue > +1 DE. El puntaje z de los indicadores del brazo relacionados a reservas grasa y masa muscular tanto en el grupo de estenosis como de disfagia se localizó en el lado negativo de la curva y ambos fueron significativamente menores a los del grupo sin disfagia o estenosis.Conclusiones: la proporción de esofagitis erosiva, estenosis o disfagia fue elevada. En los niños con disfagia o estenosis esofágica se identificaron reservas de grasa y masa muscular menores a las de los niños sin estas complicaciones. PMID:27019238

  19. [Use of leflunomide in a cytomegalovirus infection resistant: a report of a case].

    PubMed

    Gómez Valbuena, Isabel; Alioto, Daniel; Serrano Garrote, Olga; Ferrari Piquero, Jose Miguel

    2016-01-01

    Introducción: la infección por citomegalovirus (CMV) es una de las complicaciones más habituales en pacientes trasplantados, que puede desembocar en un fallo multiorgánico. El 80-90% de los pacientes se cura con el tratamiento estándar intravenoso (ganciclovir), o su profármaco oral (valganciclovir). En caso de no responder a ellos existe como alternativa otro antivírico, foscarnet. Un pequeño número de pacientes tampoco responden a este, teniendo un mal pronóstico. Objetivo: describir el caso de una paciente con trasplante bipulmonar por fibrosis quística y recidiva de infección por CMV en la cual el uso de leflunomida consigue disminuir e incluso llegar a niveles indetectables de la carga viral. Descripción del caso: mujer de 22 años, trasplantada bipulmonar por fibrosis quística en marzo del 2014. Las serologías de CMV realizadas fueron positivas en el donante y negativas en el receptor. Los controles de la carga viral durante la profilaxis con valganciclovir fueron negativos en el receptor hasta el sexto mes después del trasplante, momento en el que se detectó carga viral en los controles (2.090 UI/ml). La paciente ingresó en nuestro hospital para recibir tratamiento intravenoso con ganciclovir, persistiendo la carga viral positiva (42.400 UI/ml) al mes del inicio con esta terapia intravenosa. Un estudio de resistencias mostró que era resistente a ganciclovir, y por ello se inició tratamiento con foscarnet intravenoso. Con este fármaco se consiguió negativizar la carga viral, por lo que se suspendió el tratamiento, continuándose con controles quincenales de la carga viral. A los dos meses sin tratamiento se observó un aumento de la carga viral hasta 13.665 UI/ml, motivo por el cual se solicitó al Servicio de Farmacia el uso fuera de ficha técnica de leflunomida, con la intención de que la paciente recibiera terapia oral en lugar de intravenosa. La paciente fue tratada con valganciclovir hasta disponer de la autorización de uso de

  20. [Postoperative complications of cochlear implant: eight years of experience].

    PubMed

    Yépez-Pabón, Daniela; Guevara-Sánchez, Marco

    2015-01-01

    Introducción: el implante coclear es una cirugía con poca morbimortalidad. Las complicaciones posquirúrgicas pueden ser menores y mayores. Las menores requieren manejo conservador; las mayores, reintervención o retiro del implante. El objetivo de este trabajo es determinar nuestras complicaciones y cotejarlas con series internacionales y latinoamericanas. Métodos: se analizan retrospectivamente 275 casos intervenidos entre diciembre 2005 y diciembre 2013. Se incluyen niños y adultos entre 11 meses hasta 82 años de edad. Se evalúan datos demográficos, colocación uni o bilateral, tipo de cirugía y las complicaciones posquirúrgicas. El seguimiento fue por 20 meses. Resultados: el 57.46 % son niños y adolescentes; el 33.81 % jóvenes y adultos, y el 8.73 % adultos mayores. El índice de complicaciones es del 12 % (n = 33), 6.91 % en mujeres y 5.09 % en hombres. Entre los 19 a 60 años hay más complicaciones. Las complicaciones menores representan el 7.64 %: infección local (n = 9), parálisis facial transitoria tardía (n = 7), vértigo (n = 3) y tinnitus (n = 2). Prevalecen en niños y adultos. Las complicaciones mayores son el 4.36 %: hematomas postquirúrgicos (n = 8), extrusiones (n = 2) e inadecuada colocación de electrodos (n = 2). Predominan en los adultos entre 19 a 60 años. No se presentan casos de meningitis ni decesos. Conclusiones: la implantación coclear tiene baja incidencia de complicaciones. Nuestros resultados, los únicos reportados a nivel nacional, son similares a los que menciona la literatura.