Sample records for ionic intermediate sitting-atop
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Lim, Man Sup; Lee, Chang Hee; Sim, Songyong; Hong, Sung Kwang; Choi, Hyo Geun
2017-09-01
Since pathophysiologic evidence has been raised to suggest that obesity could facilitate an allergic reaction, obesity has been known as an independent risk factor for allergic disease such as asthma. However, the relationship between sedentary behavior and lifestyle which could lead to obesity, and those allergic diseases remains unclear. We analyzed the relations between physical activity, including sitting time for study, sitting time for leisure and sleep time, and obesity, asthma, allergic rhinitis, and atopic dermatitis using the Korea Youth Risk Behavior Web-based Survey, which was conducted in 2013. Total 53769 adolescent participants (12 through 18 years old) were analyzed using simple and multiple logistic regression analyses with complex sampling. Longer sitting time for study and short sitting time for leisure were associated with allergic rhinitis. High physical activity and short sleep time were associated with asthma, allergic rhinitis, and atopic dermatitis. Underweight was negatively associated with atopic dermatitis, whereas overweight was positively correlated with allergic rhinitis and atopic dermatitis. High physical activity, and short sleep time were associated with asthma, allergic rhinitis, and atopic dermatitis. © Copyright: Yonsei University College of Medicine 2017
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General view of a fully assembled Solid Rocket Booster sitting ...
General view of a fully assembled Solid Rocket Booster sitting atop the Mobile Launch Platform in the Vehicle Assembly Building at Kennedy Space Center - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX
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2009-02-19
VANDENBERG AIR FORCE BASE, Calif. -- On Launch Complex 576-E at Vandenberg Air Force Base in California, NASA's Orbiting Carbon Observatory, or OCO, spacecraft awaits a GN2 instrument purge flow test in preparation for launch Feb. 24. The spacecraft sits atop Orbital Sciences' Taurus XL rocket. At right is a portion of the umbilical tower attached to the upper stack. The spacecraft sits atop Orbital Sciences' Taurus XL rocket. At right is a portion of the umbilical tower attached to the upper stack. The spacecraft will collect precise global measurements of carbon dioxide (CO2) in the Earth's atmosphere. Scientists will analyze OCO data to improve our understanding of the natural processes and human activities that regulate the abundance and distribution of this important greenhouse gas. Photo courtesy of Jim Stowers, Orbital Sciences
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Specific allergen immunotherapy for the treatment of atopic eczema: a Cochrane systematic review.
Tam, H H; Calderon, M A; Manikam, L; Nankervis, H; Núñez, I G; Williams, H C; Durham, S R; Boyle, R J
2016-09-01
Specific allergen immunotherapy (SIT) is an effective allergy treatment, but it is unclear whether SIT is effective for atopic eczema (AE). We undertook a systematic review to assess SIT efficacy and safety for treating AE. We searched databases, ongoing clinical trials registers, and conference proceedings up to July 2015. Randomized controlled trials (RCTs) of SIT using standardized allergen extracts, compared with placebo/control, for treating AE in patients with allergic sensitization were eligible. We identified 12 eligible trials with 733 participants. Interventions included subcutaneous (six trials), sublingual (four trials), oral or intradermal SIT in children/adults allergic to house dust mite (10 trials), grass pollen or other inhalants. Risk of bias was moderate, with high loss to follow-up and nonblinding as the main concerns. For our primary outcomes, three studies (208 participants) reported no significant difference - patient-reported global disease severity improvement RR 0.75 (95% CI 0.45, 1.26); and eczema symptoms mean difference -0.74 on a 20-point scale (95% CI -1.98, 0.50). Two studies (85 participants) reported a significant difference - SIT improved global disease severity RR 2.85 (95% CI 1.02, 7.96); and itch mean difference -4.20 on a 10-point scale (95% CI -3.69, -4.71). Meta-analysis was limited due to extreme statistical heterogeneity. For some secondary outcomes, meta-analyses showed benefits for SIT, for example investigator-rated improvement in eczema severity RR 1.48 (95% CI 1.16, 1.88; six trials, 262 participants). We found no evidence of adverse effects. The overall quality of evidence was low. We found no consistent evidence that SIT is effective for treating AE, but due to the low quality of evidence further research is needed to establish whether SIT has a role in AE treatment. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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ERIC Educational Resources Information Center
Kubany, Elizabeth
2001-01-01
Presents a business school design in Mexico, whose spiral building sits atop a parking structure creating a compact, symbolic form for an arid urban landscape. Includes seven photographs, a floor plan, and sectional drawing. (GR)
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2009-02-19
VANDENBERG AIR FORCE BASE, Calif. -- With the fairing door off, Orbital Sciences' Glenn Weigle and Brett Gladish take the GN2 flow reading on NASA's Orbiting Carbon Observatory, or OCO, spacecraft on Launch Complex 576-E at Vandenberg Air Force Base in California. The encapsulated OCO tops Orbital Sciences' Taurus XL rocket, which is scheduled to launch Feb. 24. The spacecraft sits atop Orbital Sciences' Taurus XL rocket. At right is a portion of the umbilical tower attached to the upper stack. The spacecraft sits atop Orbital Sciences' Taurus XL rocket. At right is a portion of the umbilical tower attached to the upper stack. The spacecraft will collect precise global measurements of carbon dioxide (CO2) in the Earth's atmosphere. Scientists will analyze OCO data to improve our understanding of the natural processes and human activities that regulate the abundance and distribution of this important greenhouse gas. Photo courtesy of Jim Stowers, Orbital Sciences
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2009-02-19
VANDENBERG AIR FORCE BASE, Calif. -- With the fairing door off, Orbital Sciences' Glenn Weigle and Brett Gladish maneuver into position to take the GN2 flow reading from NASA's Orbiting Carbon Observatory, or OCO, spacecraft. At left, Jose Castillo and Mark Neuse stand by to replace the fairing door when the OCO operation is complete. The spacecraft sits atop Orbital Sciences' Taurus XL rocket. At right is a portion of the umbilical tower attached to the upper stack. The spacecraft sits atop Orbital Sciences' Taurus XL rocket. At right is a portion of the umbilical tower attached to the upper stack. The spacecraft will collect precise global measurements of carbon dioxide (CO2) in the Earth's atmosphere. Scientists will analyze OCO data to improve our understanding of the natural processes and human activities that regulate the abundance and distribution of this important greenhouse gas. Photo courtesy of Jim Stowers, Orbital Sciences
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Close-up view of Mercury-Atlas 4 at Cape Canaveral
1961-09-13
S90-27205 (13 Sept. 1961) --- The unmanned Mercury-Atlas (MA-4) capsule sits atop its Atlas launch vehicle. The successful orbital flight followed the MA-3 mission, which was aborted earlier this year. Photo credit: NASA
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Orbiter "Enterprise" rides "piggy-back" atop NASA 747 carrier
1977-09-23
S77-28649 (23 Sept 1977) --- The shuttle Orbiter 101 "Enterprise" sits atop the NASA 747 carrier aircraft in a piggy-back configuration prior to separation for the third free flight of the Shuttle Approach and Landing Tests (ALT) conducted on September 23, 1977, at the Dryden Flight Research Center (DFRC) in Southern California. The crew of the "enterprise" consisted of astronauts Fred W. Haise Jr., commander, and C. Gordon Fullerton, pilot. This photo was shot from one of the T-38 chase planes accompanying the ALT craft. Three other T-38 chase planes are pictured.
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1994-04-12
The Atlas-1 (AC-77) that will loft the Geostationary Operational Environmental Satellite-J (GOES-J) next-generation advanced technology weather satellite into space sits poised for takeoff during final countdown operations at Cape Canaveral Air Station, Kennedy Space Center (KSC). GOES-J is atop the expendable launch vehicle inside the rocket's payload fairing.
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54. DETAIL OF GENERAL ELECTRIC AIRBORNE BEACON EQUIPMENT TEST SET ...
54. DETAIL OF GENERAL ELECTRIC AIRBORNE BEACON EQUIPMENT TEST SET (LEFT) AND ASSOCIATED GOULD BRUSH CHART RECORDERS (RIGHT). ELAPSED TIME COUNTER SITS ATOP AIRBORNE BEACON EQUIPMENT TEST SET. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA
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Nebgen, Benjamin Tyler; Magurudeniya, Harsha D.; Kwock, Kevin Wen Chi; ...
2017-07-18
Molecular dynamics simulations (up to the nanoscale) were performed on the 3-methyl-1-pentylimidazolium ionic liquid cation paired with three anions; chloride, nitrate, and thiocyanate as aqueous mixtures, using the effective fragment potential (EFP) method, a computationally inexpensive way of modeling intermolecular interactions. The simulations provided insight (preferred geometries, radial distribution functions and theoretical proton NMR resonances) into the interactions within the ionic domain and are validated against 1H NMR spectroscopy and small- and wide-angle X-ray scattering experiments on 1-decyl-3-methylimidazolium. Ionic liquids containing thiocyanate typically resist gelation and form poorly ordered lamellar structures upon mixing with water. Conversely, chloride, a strongly coordinatingmore » anion, normally forms strong physical gels and produces well-ordered nanostructures adopting a variety of structural motifs over a very wide range of water compositions. Nitrate is intermediate in character, whereby upon dispersal in water it displays a range of viscosities and self-assembles into nanostructures with considerable variability in the fidelity of ordering and symmetry, as a function of water content in the binary mixtures. The observed changes in the macro and nanoscale characteristics were directly correlated to ionic domain structures and intermolecular interactions as theoretically predicted by the analysis of MD trajectories and calculated RDFs. Specifically, both chloride and nitrate are positioned in the plane of the cation. Anion to cation proximity is dependent on water content. Thiocyanate is more susceptible to water insertion into the second solvent shell. Experimental 1H NMR chemical shifts monitor the site-specific competition dependence with water content in the binary mixtures. As a result, thiocyanate preferentially sits above and below the aromatic ring plane, a state disallowing interaction with the protons on the imidazolium ring.« less
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Nebgen, Benjamin T; Magurudeniya, Harsha D; Kwock, Kevin W C; Ringstrand, Bryan S; Ahmed, Towfiq; Seifert, Sönke; Zhu, Jian-Xin; Tretiak, Sergei; Firestone, Millicent A
2017-12-14
Molecular dynamics simulations (up to the nanoscale) were performed on the 3-methyl-1-pentylimidazolium ionic liquid cation paired with three anions; chloride, nitrate, and thiocyanate as aqueous mixtures, using the effective fragment potential (EFP) method, a computationally inexpensive way of modeling intermolecular interactions. The simulations provided insight (preferred geometries, radial distribution functions and theoretical proton NMR resonances) into the interactions within the ionic domain and are validated against 1 H NMR spectroscopy and small- and wide-angle X-ray scattering experiments on 1-decyl-3-methylimidazolium. Ionic liquids containing thiocyanate typically resist gelation and form poorly ordered lamellar structures upon mixing with water. Conversely, chloride, a strongly coordinating anion, normally forms strong physical gels and produces well-ordered nanostructures adopting a variety of structural motifs over a very wide range of water compositions. Nitrate is intermediate in character, whereby upon dispersal in water it displays a range of viscosities and self-assembles into nanostructures with considerable variability in the fidelity of ordering and symmetry, as a function of water content in the binary mixtures. The observed changes in the macro and nanoscale characteristics were directly correlated to ionic domain structures and intermolecular interactions as theoretically predicted by the analysis of MD trajectories and calculated RDFs. Specifically, both chloride and nitrate are positioned in the plane of the cation. Anion to cation proximity is dependent on water content. Thiocyanate is more susceptible to water insertion into the second solvent shell. Experimental 1 H NMR chemical shifts monitor the site-specific competition dependence with water content in the binary mixtures. Thiocyanate preferentially sits above and below the aromatic ring plane, a state disallowing interaction with the protons on the imidazolium ring.
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Jutel, Marek; Solarewicz-Madejek, Katarzyna; Smolinska, Sylwia
2012-01-01
Allergen specific immunotherapy (SIT) is the only known causative treatment of allergic diseases. Recombinant allergen-based vaccination strategies arose from a strong need to both to improve safety and enhance efficacy of SIT. In addition, new vaccines can be effective in allergies including food allergy or atopic dermatitis, which poorly respond to the current treatment with allergen extracts. A number of successful clinical studies with both wild-type and hypoallergenic derivatives of recombinant allergens vaccines have been reported for the last decade. They showed high efficacy and safety profile as well as very strong modulation of T and B cell responses to specific allergens. PMID:23095874
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STS-34 Atlantis, OV-104, crew eats preflight breakfast at KSC O and C Bldg
NASA Technical Reports Server (NTRS)
1989-01-01
STS-34 crewmembers, wearing mission t-shirts, eat preflight breakfast at Kennedy Space Center (KSC) Operations and Checkout (O and C) Building before boarding Atlantis, Orbiter Vehicle (OV) 104. Sitting around table (left to right) are Commmander Donald E. Williams, Mission Specialist (MS) Franklin R. Chang-Diaz, MS Shannon W. Lucid, MS Ellen S. Baker, and Pilot Michael J. McCulley. A jack-o-lantern (pumpkin) carved with the STS-34 mission insignia is in the center of the table decorated with a mission baseball cap and sitting atop a flight jacket.
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Inexpensive Dramatic Pneumatic Lift
ERIC Educational Resources Information Center
Morse, Robert A.
2017-01-01
Various experiments and demonstrations relate air pressure and air pressure difference to force and area. Carpenter and Minnix describe a large-scale pneumatic lift in which a person sitting on a board atop a plastic garbage bag is lifted when the bag is connected to the exhaustport of a vacuum cleaner, which easily lifts the person. This article…
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Lees, J. P.; Poireau, V.; Tisserand, V.; ...
2017-03-06
Here, we study the processes e + e - → Kmore » $$0\\atop{S}$$ K$$0\\atop{L}$$ π 0 γ , K $$0\\atop{S}$$ K$$0\\atop{L}$$ η γ , and K$$0\\atop{S}$$ K$$0\\atop{L}$$ π 0 π 0 γ , where the photon is radiated from the initial state, providing cross section measurements for the hadronic final states over a continuum of center-of-mass energies. The results are based on 469 fb -1 of data collected at or near the Υ ( 4 S ) resonance with the BABAR detector at SLAC. We present the first measurements of the e + e - → K$$0\\atop{S}$$ K$$0\\atop{L}$$ π 0 , K$$0\\atop{S}$$ K$$0\\atop{L}$$ η , and K$$0\\atop{S}$$ K$$0\\atop{L}$$ π 0π 0 cross sections up to a center-of-mass energy of 4 GeV and study their intermediate resonance structures. We observe J / ψ decays to all of these final states for the first time, present measurements of their J / ψ branching fractions, and search for ψ (2S) decays.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Lees, J. P.; Poireau, V.; Tisserand, V.
Here, we study the processes e + e - → Kmore » $$0\\atop{S}$$ K$$0\\atop{L}$$ π 0 γ , K $$0\\atop{S}$$ K$$0\\atop{L}$$ η γ , and K$$0\\atop{S}$$ K$$0\\atop{L}$$ π 0 π 0 γ , where the photon is radiated from the initial state, providing cross section measurements for the hadronic final states over a continuum of center-of-mass energies. The results are based on 469 fb -1 of data collected at or near the Υ ( 4 S ) resonance with the BABAR detector at SLAC. We present the first measurements of the e + e - → K$$0\\atop{S}$$ K$$0\\atop{L}$$ π 0 , K$$0\\atop{S}$$ K$$0\\atop{L}$$ η , and K$$0\\atop{S}$$ K$$0\\atop{L}$$ π 0π 0 cross sections up to a center-of-mass energy of 4 GeV and study their intermediate resonance structures. We observe J / ψ decays to all of these final states for the first time, present measurements of their J / ψ branching fractions, and search for ψ (2S) decays.« less
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2002-12-09
KENNEDY SPACE CENTER, FLA. -- Space Shuttle Columbia sits on Launch Pad 39A, atop the Mobile Launcher Platform. The STS-107 research mission comprises experiments ranging from material sciences to life sciences, plus the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) that incorporates eight high priority secondary attached shuttle experiments. Mission STS-107 is scheduled to launch Jan. 16, 2003.
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Ming, Wenmei; Chen, Shiyou; East China Normal Univ.; ...
2016-10-13
Methylammonium (MA) lead triiodide (MAPbI 3) has recently emerged as a promising solar cell material. But, MAPbI3 is known to have chemical instability, i.e., MAPbI3 is prone to decomposition into MAI and PbI 2 even at moderate temperatures (e.g. 330 K). Here, we show that the chemical instability, as reflected by the calculated negligible enthalpy of formation of MAPbI 3 (with respect to MAI and PbI 2), has an unusual and important consequence for defect properties, i.e., defect formation energies in low-carrier-density MAPbI 3 are nearly independent of the chemical potentials of constituent elements and thus can be uniquely determined. This allows straightforward calculations of defect concentrations and the activation energy of ionic conductivity (the sum of the formation energy and the diffusion barrier of the charged mobile defect) in MAPbI 3. Furthermore, the calculated activation energy for ionic conductivity due to Vmore » $$+\\atop{1}$$ diffusion is in excellent agreement with the experimental values, which demonstrates unambiguously that V$$+\\atop{1}$$ is the dominant diffusing defect and is responsible for the observed ion migration and device polarization in MAPbI3 solar cells. The calculated low formation energy of a Frenkel pair (V$$+\\atop{1}$$ -I$$-\\atop{i}$$ and low diffusion barriers of V$$+\\atop{1}$$ and Image I$$-\\atop{i}$$ suggest that the iodine ion migration and the resulting device polarization may occur even in single-crystal devices and grain-boundary-passivated polycrystalline thin film devices (which were previously suggested to be free from ion-migration-induced device polarization), leading to device degradation. Moreover, the device polarization due to the Frenkel pair (which has a relatively low concentration) may take a long time to develop and thus may avoid the appearance of the current–voltage hysteresis at typical scan rates.« less
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Aaboud, M.; Aad, G.; Abbott, B.; ...
2018-02-22
Here, a search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1fb -1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. No significant deviation from the expected Standard Model background is observed. Limits are derived in scenarios ofmore » $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$\\bar{1}$$ pair production and of $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$0\\atop{2}$$ and $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$\\bar{1}$$ production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the $$\\sim\\atop{\\tau}_L$$ state is set to be halfway between the masses of the $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and the $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$\\bar{1}$$ for a massless $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$. Common $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and $$\\sim\\atop{\\chi}$$ $$0\\atop{2}$$ masses up to 760 GeV are excluded in the case of production of $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$0\\atop{2}$$ and $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$-\\atop{1}$$ assuming a massless $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the Open image in new window $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and the $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$ are also studied by varying the $$\\sim\\atop{\\tau}_L$$ mass between the masses of the $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and the $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaboud, M.; Aad, G.; Abbott, B.
Here, a search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1fb -1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. No significant deviation from the expected Standard Model background is observed. Limits are derived in scenarios ofmore » $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$\\bar{1}$$ pair production and of $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$0\\atop{2}$$ and $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$\\bar{1}$$ production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the $$\\sim\\atop{\\tau}_L$$ state is set to be halfway between the masses of the $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and the $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$\\bar{1}$$ for a massless $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$. Common $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and $$\\sim\\atop{\\chi}$$ $$0\\atop{2}$$ masses up to 760 GeV are excluded in the case of production of $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$0\\atop{2}$$ and $$\\sim\\atop{\\chi}$$ $$+\\atop{1}$$ $$\\sim\\atop{\\chi}$$ $$-\\atop{1}$$ assuming a massless $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the Open image in new window $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and the $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$ are also studied by varying the $$\\sim\\atop{\\tau}_L$$ mass between the masses of the $$\\sim\\atop{\\chi}$$ $$±\\atop{1}$$ and the $$\\sim\\atop{\\chi}$$ $$0\\atop{1}$$.« less
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2017-05-04
An osprey sits in its nest atop a wooden speaker pole at NASA's Kennedy Space Center in Florida. In the background is the NASA insignia on the exterior of the iconic Vehicle Assemble Building. The center shares a border with the Merritt Island National Wildlife Refuge. More than 330 native and migratory bird species, 25 mammals, 117 fishes and 65 amphibians and reptiles call Kennedy and the wildlife refuge home.
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STS-92 - Towing of Shuttle Discovery and Boeing 747 Shuttle Carrier Aircraft (SCA)
2000-11-02
The Space Shuttle Discovery sits atop one of NASA’s modified Boeing 747 Shuttle Carrier Aircraft as the unusual piggyback duo is towed along a taxiway at NASA’s Dryden Flight Research Center at Edwards, California. The Discovery was ferried from NASA Dryden to NASA’s Kennedy Space Center in Florida on November 2, 2000, after extensive pre-ferry servicing and preparations.
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Specific allergen immunotherapy for the treatment of atopic eczema.
Tam, Herman; Calderon, Moises A; Manikam, Logan; Nankervis, Helen; García Núñez, Ignacio; Williams, Hywel C; Durham, Stephen; Boyle, Robert J
2016-02-12
Specific allergen immunotherapy (SIT) is a treatment that may improve disease severity in people with atopic eczema (AE) by inducing immune tolerance to the relevant allergen. A high quality systematic review has not previously assessed the efficacy and safety of this treatment. To assess the effects of specific allergen immunotherapy (SIT), including subcutaneous, sublingual, intradermal, and oral routes, compared with placebo or a standard treatment in people with atopic eczema. We searched the following databases up to July 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 7, 2015), MEDLINE (from 1946), EMBASE (from 1974), LILACS (from 1982), Web of Science™ (from 2005), the Global Resource of EczemA Trials (GREAT database), and five trials databases. We searched abstracts from recent European and North American allergy meetings and checked the references of included studies and review articles for further references to relevant trials. Randomised controlled trials (RCTs) of specific allergen immunotherapy that used standardised allergen extracts in people with AE. Two authors independently undertook study selection, data extraction (including adverse effects), assessment of risk of bias, and analyses. We used standard methodological procedures expected by Cochrane. We identified 12 RCTs for inclusion in this review; the total number of participants was 733. The interventions included SIT in children and adults allergic to either house dust mite (10 trials), grass pollen, or other inhalant allergens (two trials). They were administered subcutaneously (six trials), sublingually (four trials), orally, or intradermally (two trials). Overall, the risk of bias was moderate, with high loss to follow up and lack of blinding as the main methodological concern.Our primary outcomes were 'Participant- or parent-reported global assessment of disease severity at the end of treatment'; 'Participant- or parent-reported specific symptoms of eczema, by subjective measures'; and 'Adverse events, such as acute episodes of asthma or anaphylaxis'. SCORing Atopic Dermatitis (SCORAD) is a means of measuring the effect of atopic dermatitis by area (A); intensity (B); and subjective measures (C), such as itch and sleeplessness, which we used.For 'Participant- or parent-reported global assessment of disease severity at the end of treatment', one trial (20 participants) found improvement in 7/9 participants (78%) treated with the SIT compared with 3/11 (27%) treated with the placebo (risk ratio (RR) 2.85, 95% confidence interval (CI) 1.02 to 7.96; P = 0.04). Another study (24 participants) found no difference: global disease severity improved in 8/13 participants (62%) treated with the SIT compared with 9/11 (81%) treated with the placebo (RR 0.75, 95% CI 0.45 to 1.26; P = 0.38). We did not perform meta-analysis because of high heterogeneity between these two studies. The quality of the evidence was low.For 'Participant- or parent-reported specific symptoms of eczema, by subjective measures', two trials (184 participants) did not find that the SIT improved SCORAD part C (mean difference (MD) -0.74, 95% CI -1.98 to 0.50) or sleep disturbance (MD -0.49, 95% CI -1.03 to 0.06) more than placebo. For SCORAD part C itch severity, these two trials (184 participants) did not find that the SIT improved itch (MD -0.24, 95% CI -1.00 to 0.52). One other non-blinded study (60 participants) found that the SIT reduced itch compared with no treatment (MD -4.20, 95% CI -3.69 to -4.71) and reduced the participants' overall symptoms (P < 0.01), but we could not pool these three studies due to high heterogeneity. The quality of the evidence was very low.Seven trials reported systemic adverse reactions: 18/282 participants (6.4%) treated with the SIT had a systemic reaction compared with 15/210 (7.1%) with no treatment (RR 0.78, 95% CI 0.41 to 1.49; the quality of the evidence was moderate). The same seven trials reported local adverse reactions: 90/280 participants (32.1%) treated with the SIT had a local reaction compared with 44/204 (21.6%) in the no treatment group (RR 1.27, 95% CI 0.89 to 1.81). As these had the same study limitations, we deemed the quality of the evidence to also be moderate.Of our secondary outcomes, there was a significant improvement in 'Investigator- or physician-rated global assessment of disease severity at the end of treatment' (six trials, 262 participants; RR 1.48, 95% CI 1.16 to 1.88). None of the studies reported our secondary outcome 'Parent- or participant-rated eczema severity assessed using a published scale', but two studies (n = 184), which have been mentioned above, used SCORAD part C, which we included as our primary outcome 'Participant- or parent-reported specific symptoms of eczema, by subjective measures'.Our findings were generally inconclusive because of the small number of studies. We were unable to determine by subgroup analyses a particular type of allergen or a particular age or level of disease severity where allergen immunotherapy was more successful. We were also unable to determine whether sublingual immunotherapy was associated with more local adverse reactions compared with subcutaneous immunotherapy. Overall, the quality of the evidence was low. The low quality was mainly due to the differing results between studies, lack of blinding in some studies, and relatively few studies reporting participant-centred outcome measures. We found limited evidence that SIT may be an effective treatment for people with AE. The treatments used in these trials were not associated with an increased risk of local or systemic reactions. Future studies should use high quality allergen formulations with a proven track record in other allergic conditions and should include participant-reported outcome measures.
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Cytokine synthesis in occupational allergy to caddisflies in hydroelectric plant workers.
Warrington, R J; Whitman, C; McPhillips Warrington, S
2003-10-01
Workers in hydroelectric plants appear to be readily sensitized to caddisfly allergens. This sensitization probably occurs de novo from occupational exposure. In some workers, sensitization occurs on a non-atopic background. Cytokine synthesis of IFN-gamma, IL-5 and IL-13 in atopic and non-atopic caddisfly-allergic workers was examined to determine if responses were similar or different. Peripheral blood mononuclear cells were isolated from atopic caddisfly-allergic workers, non-atopic caddisfly-allergic workers and non-atopic caddisfly-exposed but non-allergic workers. Stimulation with caddisfly antigens was carried out and synthesis of IFN-gamma, IL-5 and IL-13 was determined by sandwich ELISA. Both caddisfly-allergic and non-allergic subjects responded to stimulation with caddisfly extract. The response in non-atopic caddisfly-non-allergic subjects was TH1 predominant, while that in atopic caddisfly-allergic subjects was TH2 predominant. The response in non-atopic caddisfly-allergic subjects was between that of the atopic caddisfly-allergic workers and the non-atopic caddisfly-non-allergic workers and the trend was to a TH2 response. Work-related symptoms were similarly intermediate between the atopic caddisfly-allergic and non-atopic caddisfly-non-allergic group. Differences were significant for IFN-gamma/IL-5 ratios but not IFN-gamma/IL-13 ratios for atopic and non-atopic caddisfly-allergic individuals, compared to non-atopic caddisfly-non-allergic workers. However, a linear relationship existed between IFN-gamma synthesis and IL-5 and IL-13 synthesis in non-atopic caddisfly-allergic workers but not in atopic caddisfly-allergic subjects. Caddisfly allergy in hydroelectric workers may be a useful model for the development of allergy to a previously unencountered allergen, and points to some interesting differences between atopic and non-atopic subjects who become sensitized to environmental allergens. Copyright 2003 S. Karger AG, Basel
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Endeavour sitting atop NASA's Shuttle Carrier Aircraft (SCA)
2012-09-19
Space Shuttle Endeavour is ferried by NASA's Shuttle Carrier Aircraft (SCA) over the Johnson Space Center in Houston, Texas on September 19, 2012. NASA pilots Jeff Moultrie and Bill Rieke are at the controls of the Shuttle Carrier Aircraft. Photo taken by NASA photographer Sheri Locke in the backseat of a NASA T-38 chase plane with NASA pilot Thomas E. Parent at the controls. Photo Credit: NASA/ Sheri Locke
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Inexpensive Dramatic Pneumatic Lift
NASA Astrophysics Data System (ADS)
Morse, Robert A.
2017-09-01
Various experiments and demonstrations relate air pressure and air pressure difference to force and area. Carpenter and Minnix describe a large-scale pneumatic lift in which a person sitting on a board atop a plastic garbage bag is lifted when the bag is connected to the exhaustport of a vacuum cleaner, which easily lifts the person. This article describes the construction and use of an inexpensive hand-held pneumatic lift to demonstrate the same principle.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Lees, J. P.; Poireau, V.; Tisserand, V.
The processes e + e - → Kmore » $$0\\atop{S}$$ K ±π ∓π 0 and e + e - → K$$0\\atop{S}$$ K ±π ∓η are studied over a continuum of energies from threshold to 4 GeV with the initial-state photon radiation method. Using 454 fb -1 of data collected with the BABAR detector at the SLAC PEP-II storage ring, the first measurements of the cross sections for these processes are obtained. The intermediate resonance structures from K* 0(Kπ) 0, K *(892) ± (Kπ) ∓ , and K$$0\\atop{S}$$K ±ρ ∓ are studied. Lastly, the J / ψ is observed in all of these channels, and corresponding branching fractions are measured.« less
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Lees, J. P.; Poireau, V.; Tisserand, V.; ...
2017-05-30
The processes e + e - → Kmore » $$0\\atop{S}$$ K ±π ∓π 0 and e + e - → K$$0\\atop{S}$$ K ±π ∓η are studied over a continuum of energies from threshold to 4 GeV with the initial-state photon radiation method. Using 454 fb -1 of data collected with the BABAR detector at the SLAC PEP-II storage ring, the first measurements of the cross sections for these processes are obtained. The intermediate resonance structures from K* 0(Kπ) 0, K *(892) ± (Kπ) ∓ , and K$$0\\atop{S}$$K ±ρ ∓ are studied. Lastly, the J / ψ is observed in all of these channels, and corresponding branching fractions are measured.« less
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ERIC Educational Resources Information Center
Shillington, V. George
2013-01-01
Etched on a stone from a monastery from the Middle Ages at a small village in County Roscommon in Ireland is a combination of Jewish and Christian symbols. The Menorah sits atop a cross. At the base of the cross and at both ends of the crossbar are three small extensions. The image is one of religious integration. Augustine, whose argument for the…
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Right Whale Diving and Foraging Behavior in the Southwestern Gulf of Maine
2011-09-30
whale sits atop a relatively simple food chain consisting only of phytoplankton, copepods , and whales that can serve as a convenient model to study...influence the vertical distribution of copepods . APPROACH Tagging, tracking, and sampling around right whales was accomplished with two...above this depth feeding on a shallow layer of copepods (Figure 3f). We were able to confirm that this tagged whale was feeding by observing its
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2002-12-09
KENNEDY SPACE CENTER, FLA. -- Space Shuttle Columbia rolls towards Launch Pad 39A, sitting atop the Mobile Launcher Platform, which in turn is carried by the crawler-transporter underneath. The STS-107 research mission comprises experiments ranging from material sciences to life sciences (many rats), plus the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) that incorporates eight high priority secondary attached shuttle experiments. Mission STS-107 is scheduled to launch Jan. 16, 2003.
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Recent highlights from IceCube
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kappes, A.; Collaboration: IceCube Collaboration
2014-11-18
The IceCube Neutrino Observatory, completed in December 2010, is located at the geographic South Pole and incorporates a one cubic kilometer neutrino detector buried in the deep ice and a one square kilometer air shower array, IceTop, sitting atop the glacial ice. This unique combination of neutrino and cosmic-ray detectors allows to investigate a wide variety of physics topics both in astrophysics and particle physics. Here, we discuss latest results from IceCube concentrating on astrophysical aspects.
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2010-03-17
A view inside the NASA Goddard clean room where the James Webb Space Telescope (JWST) is being built. This images shows Goddard technicians lifting the ISIM (Integrated Science Instrument Module) onto the ITS (ISIM Test Structure). ISIM will sit atop this platform during space environmental testing. Credit: NASA/GSFC/Chris Gunn For more information on JWST go to: www.jwst.nasa.gov/ For more information on Goddard Space Flight Center go to: www.nasa.gov/centers/goddard/home/index.html
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Evaluation of the AMEREX Model 775 Wheeled Extinguisher with Novec 1230
2014-11-18
simulate different fire scenarios. The nacelle sits atop a concave concrete pad that can collect a pool of jet fuel as part of the fire scenario...Up Used for Rear Engine Testing and Access Panel Testing. In This Photo, Fuel is Flowing through the Nacelle in Preparation for a Rear Engine Test...Figure 8. Fuel Cups Positioned At 5-ft Intervals from the Amerex Extinguisher (Background) (left); Firefighter Discharges the Extinguisher into/over the
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Bardoczi, Laszlo; Rhodes, Terry L.; Navarro, Alejandro Banon; ...
2017-03-03
We present the first localized measurements of long and intermediate wavelength turbulent density fluctuations (more » $$\\sim\\atop{n}$$) and long wavelength turbulent electron temperature fluctuations ($$\\sim\\atop{T}$$ e) modified by m/n = 2/1 Neoclassical Tearing Mode (NTM) islands (m and n are the poloidal and toroidal mode numbers, respectively). These long and intermediate wavelengths correspond to the expected Ion Temperature Gradient and Trapped Electron Mode scales, respectively. Two regimes have been observed when tracking $$\\sim\\atop{n}$$ during NTM evolution: (1) small islands are characterized by a steep T e radial profile and turbulence levels comparable to those of the background; (2) large islands have a flat T e profile and reduced turbulence level at the O-point. Radially outside the large island, the T e profile is steeper and the turbulence level increased compared to the no or small island case. Reduced turbulence at the O-point compared to the X-point leads to a 15% modulation of $$\\sim\\atop{n}$$ 2 across the island that is nearly in phase with the T e modulation. Qualitative comparisons to the GENE non-linear gyrokinetic code are promising with GENE replicating the observed scaling of turbulence modification with island size. Furthermore, these results are significant as they allow the validation of gyrokinetic simulations modeling the interaction of these multi-scale phenomena.« less
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Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; ...
2017-02-10
An inclusive search is performed for supersymmetry in final states containing jets and an apparent imbalance in transverse momentum,more » $$→\\atop{p}$$ $$miss\\atop{T}$$, due to the production of unobserved weakly interacting particles in pp collisions at a centre-of-mass energy of 8 TeV. The data, recorded with the CMS detector at the CERN LHC, correspond to an integrated luminosity of 18.5 fb $-$1 . The dimensionless kinematic variable α T is used to discriminate between events with genuine $$→\\atop{p}$$ $$miss\\atop{T}$$ associated with unobserved particles and spurious values of $$→\\atop{p}$$ $$miss\\atop{T}$$ arising from jet energy mismeasurements. No excess of event yields above the expected standard model backgrounds is observed. The results are interpreted in terms of constraints on the parameter space of several simplified models of supersymmetry that assume the pair production of top squarks. The search provides sensitivity to a broad range of top squark ($$\\sim\\atop{t}$$) decay modes, including the two-body decay $$\\sim\\atop{t}$$→c$$\\sim\\atop{\\chi}$$$0\\atop{1}$$ , where c is a charm quark and$$\\sim\\atop{\\chi}$$$0\\atop{1}$$ is the lightest neutralino, as well as the four-body decay $$\\sim\\atop{t}$$→bf$$\\bar{f}$$'χ$$\\sim\\atop{\\chi}$$$0\\atop{1}$$ , where b is a bottom quark and f and$$\\bar{f}$$' are fermions produced in the decay of an intermediate off-shell W boson. Furthermore, these modes dominate in scenarios in which the top squark and lightest neutralino are nearly degenerate in mass. For these modes, top squarks with masses as large as 260 and 225 GeV are excluded, respectively, for the two- and four-body decays.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.
An inclusive search is performed for supersymmetry in final states containing jets and an apparent imbalance in transverse momentum,more » $$→\\atop{p}$$ $$miss\\atop{T}$$, due to the production of unobserved weakly interacting particles in pp collisions at a centre-of-mass energy of 8 TeV. The data, recorded with the CMS detector at the CERN LHC, correspond to an integrated luminosity of 18.5 fb $-$1 . The dimensionless kinematic variable α T is used to discriminate between events with genuine $$→\\atop{p}$$ $$miss\\atop{T}$$ associated with unobserved particles and spurious values of $$→\\atop{p}$$ $$miss\\atop{T}$$ arising from jet energy mismeasurements. No excess of event yields above the expected standard model backgrounds is observed. The results are interpreted in terms of constraints on the parameter space of several simplified models of supersymmetry that assume the pair production of top squarks. The search provides sensitivity to a broad range of top squark ($$\\sim\\atop{t}$$) decay modes, including the two-body decay $$\\sim\\atop{t}$$→c$$\\sim\\atop{\\chi}$$$0\\atop{1}$$ , where c is a charm quark and$$\\sim\\atop{\\chi}$$$0\\atop{1}$$ is the lightest neutralino, as well as the four-body decay $$\\sim\\atop{t}$$→bf$$\\bar{f}$$'χ$$\\sim\\atop{\\chi}$$$0\\atop{1}$$ , where b is a bottom quark and f and$$\\bar{f}$$' are fermions produced in the decay of an intermediate off-shell W boson. Furthermore, these modes dominate in scenarios in which the top squark and lightest neutralino are nearly degenerate in mass. For these modes, top squarks with masses as large as 260 and 225 GeV are excluded, respectively, for the two- and four-body decays.« less
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Yamaguchi, Tsuyoshi; Yonezawa, Takuya; Koda, Shinobu
2015-07-15
The frequency-dependent viscosity and conductivity of three imidazolium-based ionic liquids were measured at several temperatures in the MHz region, and the results are compared with the intermediate scattering functions determined by neutron spin echo spectroscopy. The relaxations of both the conductivity and the viscosity agree with that of the intermediate scattering function at the ionic correlation when the relaxation time is short. As the relaxation time increases, the relaxations of the two transport properties deviate to lower frequencies than that of the ionic structure. The deviation begins at a shorter relaxation time for viscosity than for conductivity, which explains the fractional Walden rule between the zero-frequency values of the shear viscosity and the molar conductivity.
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STS-27 Atlantis, Orbiter Vehicle (OV) 104, at KSC Launch Complex (LC) pad 39B
NASA Technical Reports Server (NTRS)
1988-01-01
STS-27 Atlantis, Orbiter Vehicle (OV) 104, sits atop the mobile launcher platform at Kennedy Space Center (KSC) Launch Complex (LC) pad 39B. Profile of OV-104 mounted on external tank and flanked by solid rocket boosters (SRBs) is obscured by a flock of seagulls in the foreground. The fixed service structure (FSS) with rotating service structure (RSS) retracted appears in the background. Water resevoir is visible at the base of the launch pad concrete structure.
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Hierarchy of evidence: where observational studies fit in and why we need them.
Hoppe, Daniel J; Schemitsch, Emil H; Morshed, Saam; Tornetta, Paul; Bhandari, Mohit
2009-05-01
Although randomized controlled designs are considered the so-called gold standard in medical trials and sit atop the hierarchy of evidence in evidence-based medicine, there are situations in which they are impractical or unethical to undertake, especially in surgical trials. Then, observational studies often provide the best source of information. In this paper, we use examples from the literature to explain the importance of observational studies in furthering the boundaries of orthopaedic surgery and knowledge of musculoskeletal disorders.
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STS-107 Columbia rollout to Launch Pad 39A
NASA Technical Reports Server (NTRS)
2002-01-01
KENNEDY SPACE CENTER, FLA. -- Space Shuttle Columbia, framed by trees near the Banana River, rolls towards Launch Pad 39A, sitting atop the Mobile Launcher Platform, which in turn is carried by the crawler-transporter underneath. The STS-107 research mission comprises experiments ranging from material sciences to life sciences (many rats), plus the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) that incorporates eight high priority secondary attached shuttle experiments. Mission STS-107 is scheduled to launch Jan. 16, 2003.
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2004-07-13
VANDENBERG AFB, CALIF. - The Aura spacecraft atop its Boeing Delta II launch vehicle sits on NASA’s Space Complex 2 at Vandenberg Air Force Base in California waiting to launch. Liftoff is now scheduled for no earlier than July 14. The latest in the Earth Observing System (EOS) series, Aura’s four state-of-the-art instruments will study the dynamics of chemistry occurring in the atmosphere. The spacecraft will provide data to help scientists better understand the Earth’s ozone, air quality and climate change. [Photo by Bill Ingalls/NASA
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Wiens, Roger
Better understanding Mars means better understanding its geology. That’s why, sitting atop NASA’s Curiosity rover, is ChemCam, an instrument built by Los Alamos National Laboratory that shoots lasers at Martian rocks and analyzes the data. After nearly 1,500 rock zaps, ChemCam has uncovered some surprising facts about the Red Planet, including the discovery of igneous rocks. Soon, a new Los Alamos-built instrument—the SuperCam—will ride aboard the Mars 2020 rover and bring with it enhanced capabilities to unlock new secrets about the planet.
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2012-08-06
CAPE CANAVERAL, Fla. – The Orion mockup spacecraft sits atop its service module simulator in the transfer aisle of the Vehicle Assembly Building, or VAB, at NASA's Kennedy Space Center in Florida. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The first uncrewed test flight of the Orion is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on a Space Launch System rocket. The Orion mockup is exact in details on the outside, but mostly empty on the inside except for four mockup astronaut seats and hatch. The work in the VAB is crucial to making sure the designs are accurate. For more information, visit http://www.nasa.gov/orion Photo credit: NASA/ Dmitri Gerondidakis
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2012-08-06
CAPE CANAVERAL, Fla. – The Orion mockup spacecraft sits atop its service module simulator in the transfer aisle of the Vehicle Assembly Building, or VAB, at NASA's Kennedy Space Center in Florida. To the left is the aerodynamic shell that will cover the capsule during launch. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The first uncrewed test flight of the Orion is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on a Space Launch System rocket. The Orion mockup is exact in details on the outside, but mostly empty on the inside except for four mockup astronaut seats and hatch. The work in the VAB is crucial to making sure the designs are accurate. For more information, visit http://www.nasa.gov/orion Photo credit: NASA/ Dmitri Gerondidakis
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2012-08-06
CAPE CANAVERAL, Fla. – The Orion mockup spacecraft sits atop its service module simulator in the transfer aisle of the Vehicle Assembly Building, or VAB, at NASA's Kennedy Space Center in Florida. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The first uncrewed test flight of the Orion is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on a Space Launch System rocket. The Orion mockup is exact in details on the outside, but mostly empty on the inside except for four mockup astronaut seats and hatch. The work in the VAB is crucial to making sure the designs are accurate. For more information, visit http://www.nasa.gov/orion Photo credit: NASA/ Dmitri Gerondidakis
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Siman, Isabella Lima; de Aquino, Lais Martins; Ynoue, Leandro Hideki; Miranda, Juliana Silva; Pajuaba, Ana Claudia Arantes Marquez; Cunha-Júnior, Jair Pereira; Silva, Deise Aparecida Oliveira; Taketomi, Ernesto Akio
2013-01-01
One of the purposes of specific immunotherapy (SIT) is to modulate humoral immune response against allergens with significant increases in allergen-specific IgG levels, commonly associated with blocking activity. The present study investigated in vitro blocking activity of allergen-specific IgG antibodies on IgE reactivity to Dermatophagoides pteronyssinus (Dpt) in sera from atopic patients. Dpt-specific IgG antibodies were purified by ammonium sulfate precipitation followed by protein-G affinity chromatography. Purity was checked by SDS-PAGE and immunoreactivity by slot-blot and immunoblot assays. The blocking activity was evaluated by inhibition ELISA. The electrophoretic profile of the ammonium sulfate precipitated fraction showed strongly stained bands in ligand fraction after chromatography, compatible with molecular weight of human whole IgG molecule. The purity degree was confirmed by detecting strong immunoreactivity to IgG, negligible to IgA, and no reactivity to IgE and IgM. Dpt-specific IgG fraction was capable of significantly reducing levels of IgE anti-Dpt, resulting in 35%-51% inhibition of IgE reactivity to Dpt in atopic patients sera. This study showed that allergen-specific IgG antibodies purified from mite-allergic patients sera block the IgE recognition of Dermatophagoides pteronyssinus antigens. This approach reinforces that intermittent measurement of serum allergen-specific IgG antibodies will be an important objective laboratorial parameter that will help specialists to follow their patients under SIT.
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Giano Intermediate School: The Parent Factor
ERIC Educational Resources Information Center
Rourke, James; Hartzman, Marlene
2009-01-01
On a Wednesday morning at Giano Intermediate School in West Covina, California, 25 mothers and fathers sit in rapt attention, many taking notes, as a school counselor outlines the morning's Parent Chat. The session is devoted to exploring how well the parents know their children. Parents complete a questionnaire that asks them to answer such…
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2014-05-02
CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, a small crab sits atop a restored sand dune along a 1.2 mile stretch of shoreline near Launch Pads 39A and B. As part of a six-month effort to help prevent further erosion, 180,000 shrubs, including grasses, sunflowers, vines, sea grapes and palmettos were planted. Constant pounding from tropical storms, such as Hurricane Sandy in October of 2012, other weather systems and higher than usual tides, destroyed sand dunes protecting infrastructure at the spaceport. Photo credit: NASA/Dan Casper
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High angle view of Apollo 14 space vehicle on way to Pad A
1970-11-09
S70-54127 (9 Nov. 1970) --- A high-angle view at Launch Complex 39, Kennedy Space Center (KSC), showing the Apollo 14 (Spacecraft 110/Lunar Module 8/Saturn 509) space vehicle on the way from the Vehicle Assembly Building (VAB) to Pad A. The Saturn V stack and its mobile launch tower sit atop a huge crawler-transporter. The Apollo 14 crewmen will be astronauts Alan B. Shepard Jr., commander; Stuart A. Roosa, command module pilot; and Edgar D. Mitchell, lunar module pilot.
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High angle view of Apollo 14 space vehicle on way to Pad A
1970-11-09
S70-54119 (9 Nov. 1970) --- A high-angle view at Launch Complex 39, Kennedy Space Center (KSC), showing the Apollo 14 (Spacecraft 110/Lunar Module 8/Saturn 509) space vehicle on the way from the Vehicle Assembly Building (VAB) to Pad A. The Saturn V stack and its mobile launch tower sit atop a huge crawler-transporter. The Apollo 14 crewmen will be astronauts Alan B. Shepard Jr., commander; Stuart A. Roosa, command module pilot; and Edgar D. Mitchell, lunar module pilot.
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1998-09-28
KENNEDY SPACE CENTER, FLA. -- At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure, is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar-observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process
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Uncovering the Mysteries of Mars Habitability
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wiens, Roger; Lanza, Nina; Clegg, Sam
Los Alamos scientists are uncovering clues about the habitability of ancient Mars using the ChemCam instrument that sits atop NASA’s Mars Curiosity rover. ChemCam has discovered 25 different elements on Mars—including manganese and boron—providing important information about conditions that could potentially have supported life on the Red Planet. Los Alamos is now developing a new instrument called SuperCam that will ride aboard the Mars 2020 rover and provide greater detail about the mineralogy and the presence of compounds related to the possibility of life on the surface of Mars.
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Limberger, Jones; Leal, Bárbara C.; Monteiro, Adriano L.
2015-01-01
In recent years, charge-tagged ligands (CTLs) have become valuable tools in organometallic catalysis. Insertion of an ionic side chain into the molecular skeleton of a known ligand has become a useful protocol for anchoring ligands, and consequently catalysts, in polar and ionic liquid phases. In addition, the insertion of a cationic moiety into a ligand is a powerful tool that can be used to detect reaction intermediates in organometallic catalysis through electrospray ionisation mass spectrometry (ESI-MS) experiments. The insertion of an ionic tag ensures the charge in the intermediates independently of the ESI-MS. For this reason, these ligands have been used as ionic probes in mechanistic studies for several catalytic reactions. Here, we summarise selected examples on the use of CTLs as immobilising agents in organometallic catalysis and as probes for studying mechanisms through ESI-MS. PMID:28553458
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Biodegradation of imidazolium ionic liquids by activated sludge microorganisms.
Liwarska-Bizukojc, Ewa; Maton, Cedric; Stevens, Christian V
2015-11-01
Biological properties of ionic liquids (ILs) have been usually tested with the help of standard biodegradation or ecotoxicity tests. So far, several articles on the identification of intermediate metabolites of microbiological decay of ILs have been published. Simultaneously, the number of novel ILs with unrecognized characteristics regarding biodegradability and effect on organisms and environment is still increasing. In this work, seven imidazolium ionic liquids of different chemical structure were studied. Three of them are 1-alkyl-3-methyl-imidazolium bromides, while the other four are tetra- or completely substituted imidazolium iodides. This study focused on the identification of intermediate metabolites of the aforementioned ionic liquids subjected to biodegradation in a laboratory activated sludge system. Both fully substituted ionic liquids and 1-ethyl-3-methyl-imidazolium bromide were barely biodegradable. In the case of two of them, no biotransformation products were detected. The elongation of the alkyl side chain made the IL more susceptible for microbiological decomposition. 1-Decyl-3-methyl-imidazolium bromide was biotransformed most easily. Its primary biodegradation up to 100 % could be achieved. Nevertheless, the cleavage of the imidazolium ring has not been observed.
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Integrity of N- and C-termini is important for E. coli Hsp31 chaperone activity
Sastry, M S R; Zhou, Weibin; Baneyx, François
2009-01-01
Hsp31 is a stress-inducible molecular chaperone involved in the management of protein misfolding at high temperatures and in the development of acid resistance in starved E. coli. Each subunit of the Hsp31 homodimer consists of two structural domains connected by a flexible linker that sits atop a continuous tract of nonpolar residues adjacent to a hydrophobic bowl defined by the dimerization interface. Previously, we proposed that while the bowl serves as a binding site for partially folded species at physiological temperatures, chaperone function under heat shock conditions requires that folding intermediates further anneal to high-affinity binding sites that become uncovered upon thermally induced motion of the linker. In support of a mechanism requiring that client proteins first bind to the bowl, we show here that fusion of a 20-residue-long hexahistidine tag to the N-termini of Hsp31 abolishes chaperone activity at all temperatures by inducing reversible structural changes that interfere with substrate binding. We further demonstrate that extending the C-termini of Hsp31 with short His tags selectively suppresses chaperone function at high temperatures by interfering with linker movement. The structural and functional sensitivity of Hsp31 to lengthening is consistent with the high degree of conservation of class I Hsp31 orthologs and will serve as a cautionary tale on the implications of affinity tagging. PMID:19517531
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Molecular Interactions at Marine Interfaces
1994-09-20
Microbial Attachment and Biofilm Formation 9:00 Michael Sinnott Structure of Extracellular Polysaccharides of Pseudomonas atlantica 9:30 Herb Waite...sit/ i u~ . Direct Measurements of the Intermolecular F~rccs Between Polysaccharide Exopolymers from marine Bacter"a and Solid Substrates Georges...aqueous medium of high ionic strength. Effect of Polysaccharide Surface Structurt on Microbial Attachment and Biofilm Formation David C. White and A
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Susman, Sherman; Volin, Kenneth J.
1984-01-01
An ionically conducting glass for use as a solid electrolyte in a power or secondary cell containing an alkali metal-containing anode and a cathode separated by an alkali metal ion conducting glass having an ionic transference number of unity and the general formula: A.sub.1+x D.sub.2-x/3 Si.sub.x P.sub.3-x O.sub.12-2x/3, wherein A is a network modifier for the glass and is an alkali metal of the anode, D is an intermediate for the glass and is selected from the class consisting of Zr, Ti, Ge, Al, Sb, Be, and Zn and X is in the range of from 2.25 to 3.0. Of the alkali metals, Na and Li are preferred and of the intermediate, Zr, Ti and Ge are preferred.
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1985-11-04
61A-40-38 (30 Oct-6 Nov 1985) --- The coral reef forming the atoll of Midway sits atop a volcanic seamount that has descended more than 3,000 feet (1000 meters) below the sea surface in this ancient region of the Hawaiian volcanic chain. This view was taken by the crew members onboard the Earth-orbiting Space Shuttle Challenger. The crew consisted of astronauts Henry W. Hartsfield, Jr., commander; Steven R. Nagel, pilot; James F. Buchli, Guion S. Bluford, Jr., and Bonnie J. Dunbar, all mission specialists; Reinhard Furrer, Ernst Messerschmid, and Wubbo J. Ockels, all payload specialists. Ockels represents the European Space Agency (ESA).
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2000-10-31
KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is ready to move from the Vehicle Assembly Building into the light of early morning on its rollout to Launch Pad 39B. The Space Shuttle sits atop the Mobile Launcher Platform (MLP). Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections
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2000-10-31
KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is ready to move from the Vehicle Assembly Building into the light of early morning on its rollout to Launch Pad 39B. The Space Shuttle sits atop the Mobile Launcher Platform (MLP). Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections
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Space Shuttle Enterprise Demate
2012-05-12
A yellow sling is lowered onto space shuttle Enterprise, which sits atop NASA's 747 Shuttle Carrier Aircraft (SCA) prior to it being demated a few hours later at John F. Kennedy (JFK) International Airport in New York, Saturday, May 12, 2012. The shuttle will be placed on a barge that will move by tugboat up the Hudson River to Intrepid in June. The shuttle will be lifted by crane and placed on the flight deck of the Intrepid, where it will be on exhibit to the public starting this summer in a temporary climate-controlled pavilion. Photo Credit: (NASA/Kim Shiflet)
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Wiens, Roger
2018-01-16
Better understanding Mars means better understanding its geology. Thatâs why, sitting atop NASAâs Curiosity rover, is ChemCam, an instrument built by Los Alamos National Laboratory that shoots lasers at Martian rocks and analyzes the data. After nearly 1,500 rock zaps, ChemCam has uncovered some surprising facts about the Red Planet, including the discovery of igneous rocks. Soon, a new Los Alamos-built instrumentâthe SuperCamâwill ride aboard the Mars 2020 rover and bring with it enhanced capabilities to unlock new secrets about the planet.
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ICPS Turnover GSDO Employee Event
2017-11-07
Kennedy Space Center Associate Director Kelvin Manning, right, speaks with a guest during a ceremony marking NASA's Spacecraft/Payload Integration and Evolution (SPIE) organization formally turning over processing of the Space Launch System (SLS) rocket's Interim Cryogenic Propulsion Stage (ICPS) to the center's Ground Systems Development and Operations (GSDO) Directorate. The ICPS is the first integrated piece of flight hardware to arrive in preparation for the uncrewed Exploration Mission-1. With the Orion attached, the ICPS sits atop the SLS rocket and will provide the spacecraft with the additional thrust needed to travel tens of thousands of miles beyond the Moon.
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Interim Cryogenic Propulsion Stage (ICPS) Handover Signing
2017-10-26
Meeting in the Launch Control Center of NASA's Kennedy Space Center in Florida, officials of the agency's Spacecraft/Payload Integration and Evolution (SPIE) organization formally turn over processing of the Space Launch System (SLS) rocket's Interim Cryogenic Propulsion Stage (ICPS) to the center's Ground Systems Development and Operations (GSDO) directorate. The ICPS is the first integrated piece of flight hardware to arrive in preparation for the uncrewed Exploration Mission-1. With the Orion attached, the ICPS sits atop the SLS rocket and will provide the spacecraft with the additional thrust needed to travel tens of thousands of miles beyond the Moon.
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Grotthuss Transport of Iodide in EMIM/I3 Ionic Crystal.
McDaniel, Jesse G; Yethiraj, Arun
2018-01-11
Highly ionic environments can mediate unusual chemical reactions that would otherwise be considered impossible based on chemical intuition. For example, the formation of a chemical bond between two iodide anions to form a divalent polyiodide anion is seemingly prohibited due to Coulombic repulsion. Using ab initio molecular dynamics simulations, we show that in the 1-ethyl-3-methylimidazolium (EMIM)/I 3 ionic crystal, the reactive formation of divalent and even trivalent polyiodide anions occurs with extremely small energetic barriers, due to the electrostatic field of the ionic lattice. A practical consequence of this anomalous reactivity is that iodide anions are efficiently transported within the crystal through a "Grotthuss-exchange" mechanism involving bond-breaking and forming events. We characterize two distinct transport pathways, involving both I 4 2- and I 7 3- intermediates, with fast transport of iodide resulting from the release of an I - anion on the opposite side of the intermediate species from the initial bond formation. The ordered cation arrangement in the crystal provides the necessary electrostatic screening for close approach of anions, suggesting a new counterintuitive approach to obtain high ionic conductivity. This new design principle could be used to develop better solid-state electrolytes for batteries, fuel cells, and supercapacitors.
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Susman, S.; Volin, K.J.
Described is an ionically conducting glass for use as a solid electrolyte in a power or secondary cell containing an alkali metal-containing anode and a cathode separated by an alkali metal ion conducting glass having an ionic transference number of unity and the general formula: A/sub 1 + x/D/sub 2-x/3/Si/sub x/P/sub 3 - x/O/sub 12 - 2x/3/, wherein A is a network modifier for the glass and is an alkali metal of the anode, D is an intermediate for the glass and is selected from the class consisting of Zr, Ti, Ge, Al, Sb, Be, and Zn and X is in the range of from 2.25 to 3.0. Of the alkali metals, Na and Li are preferred and of the intermediate, Zr, Ti and Ge are preferred.
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Brotton, Stephen J; Lucas, Michael; Chambreau, Steven D; Vaghjiani, Ghanshyam L; Yu, Jiang; Anderson, Scott L; Kaiser, Ralf I
2017-12-21
The production of the next generation of hypergolic, ionic-liquid-based fuels requires an understanding of the reaction mechanisms between the ionic liquid and oxidizer. We probed reactions between a levitated droplet of 1-methyl-4-amino-1,2,4-triazolium dicyanamide ([MAT][DCA]), with and without hydrogen-capped boron nanoparticles, and the nitrogen dioxide (NO 2 ) oxidizer. The apparatus exploits an ultrasonic levitator enclosed within a pressure-compatible process chamber equipped with complementary Raman, ultraviolet-visible, and Fourier-transform infrared (FTIR) spectroscopic probes. Vibrational modes were first assigned to the FTIR and Raman spectra of droplets levitated in argon. Spectra were subsequently collected for pure and boron-doped [MAT][DCA] exposed to nitrogen dioxide. By comparison with electronic structure calculations, some of the newly formed modes suggest that the N atom of the NO 2 molecule bonds to a terminal N on the dicyanamide anion yielding [O 2 N-NCNCN] - . This represents the first spectroscopic evidence of a key reaction intermediate in the oxidation of levitated ionic liquid droplets.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaltonen, T.; Amerio, S.; Amidei, D.
Here, at the Fermilab Tevatron proton-antiproton (pmore » $$\\bar{p}$$) collider, Drell-Yan lepton pairs are produced in the process p$$\\bar{p}$$→e +e -+X through an intermediate γ*/Z boson. The forward-backward asymmetry in the polar-angle distribution of the e - as a function of the e +e --pair mass is used to obtain sin 2θ$$lept\\atop{eff}$$, the effective leptonic determination of the electroweak-mixing parameter sin2θW. The measurement sample, recorded by the Collider Detector at Fermilab (CDF), corresponds to 9.4 fb -1 of integrated luminosity from p$$\\bar{p}$$ collisions at a center-of-momentum energy of 1.96 TeV, and is the full CDF Run II data set. The value of sin 2θ$$lept\\atop{eff}$$ is found to be 0.23248±0.00053. The combination with the previous CDF measurement based on μ +μ - pairs yields sin 2θ$$lept\\atop{eff}$$=0.23221±0.00046. This result, when interpreted within the specified context of the standard model assuming sin 2θW=1-M$$2\\atop{W}$$/M$$2\\atop{Z}$$ and that the W- and Z-boson masses are on-shell, yields sin 2θW=0.22400±0.00045, or equivalently a W-boson mass of 80.328±0.024 GeV/c 2.« less
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2013-07-26
CAPE CANAVERAL, Fla. – The Orion crew module for Exploration Flight Test 1 sits inside a clean room processing cell in the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on a Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann
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2013-07-26
CAPE CANAVERAL, Fla. – The Orion crew module for Exploration Flight Test 1 sits inside a clean room processing cell in the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on a Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann
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2004-04-21
KENNEDY SPACE CENTER, FLA. - Against the backdrop of the American flag, painted on the side of the Vehicle Assembly Building, an osprey checks its fledglings in the nest. The young bird seen is one of three hatched this season. The osprey nest sits atop a speaker in the parking lot of the NASA KSC News Center. Known as a fish hawk, ospreys select sites of opportunity, from trees and telephone poles to rocks or even flat ground. In the United States they are found from Alaska to Florida and the Gulf Coast. Osprey nests are found throughout the Kennedy Space Center and nearby Merritt Island National Wildlife Refuge.
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ICPS Turnover GSDO Employee Event
2017-11-07
In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, a ceremony is underway marking the agency's Spacecraft/Payload Integration and Evolution (SPIE) organization formally turning over processing of the Space Launch System (SLS) rocket's Interim Cryogenic Propulsion Stage (ICPS), to the center's Ground Systems Development and Operations (GSDO) Directorate. The ICPS is seen on the left in its shipping container and is the first integrated piece of flight hardware to arrive in preparation for the uncrewed Exploration Mission-1. With the Orion attached, the ICPS sits atop the SLS rocket and will provide the spacecraft with the additional thrust needed to travel tens of thousands of miles beyond the Moon.
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2009-02-19
VANDENBERG AIR FORCE BASE, Calif. -- On Launch Complex 576-E at Vandenberg Air Force Base in California, NASA's Orbiting Carbon Observatory, or OCO, spacecraft awaits a GN2 instrument purge flow test in preparation for launch Feb. 24. The spacecraft sits atop Orbital Sciences' Taurus XL rocket. At right is a portion of the umbilical tower attached to the upper stack. The spacecraft will collect precise global measurements of carbon dioxide (CO2) in the Earth's atmosphere. Scientists will analyze OCO data to improve our understanding of the natural processes and human activities that regulate the abundance and distribution of this important greenhouse gas. Photo courtesy of Jim Stowers, Orbital Sciences
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NASA Technical Reports Server (NTRS)
2004-01-01
KENNEDY SPACE CENTER, FLA. Against the backdrop of the American flag, painted on the side of the Vehicle Assembly Building, an osprey checks its fledglings in the nest. The young bird seen is one of three hatched this season. The osprey nest sits atop a speaker in the parking lot of the NASA KSC News Center. Known as a fish hawk, ospreys select sites of opportunity, from trees and telephone poles to rocks or even flat ground. In the United States they are found from Alaska to Florida and the Gulf Coast. Osprey nests are found throughout the Kennedy Space Center and nearby Merritt Island National Wildlife Refuge.
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Reiners, Eric A.; Taher, Mahmoud A.; Fei, Dong; McGilvray, Andrew N.
2007-10-30
In one particular embodiment, an internal combustion engine is provided. The engine comprises a block, a head, a piston, a combustion chamber defined by the block, the piston, and the head, and at least one thermoelectric device positioned between the combustion chamber and the head. In this particular embodiment, the thermoelectric device is in direct contact with the combustion chamber. In another particular embodiment, a cylinder head configured to sit atop a cylinder bank of an internal combustion engine is provided. The cylinder head comprises a cooling channel configured to receive cooling fluid, valve seats configured for receiving intake and exhaust valves, and thermoelectric devices positioned around the valve seats.
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Controlling the intermediate structure of an ionic liquid for f-block element separations
Abney, Carter W.; Do, Changwoo; Luo, Huimin; ...
2017-04-19
Recent research has revealed molecular structure beyond the inner coordination sphere is essential in defining the performance of separations processes, but nevertheless remains largely unexplored. Here we apply small angle neutron scattering (SANS) and x-ray absorption fine structure (XAFS) spectroscopy to investigate the structure of an ionic liquid system studied for f-block element separations. SANS data reveal dramatic changes in the ionic liquid microstructure (~150 Å) which we demonstrate can be controlled by judicious selection of counter ion. Mesoscale structural features (> 500 Å) are also observed as a function of metal concentration. XAFS analysis supports formation of extended aggregatemore » structures, similar to those observed in traditional solvent extraction processes, and suggest additional parallels may be drawn from further study. As a result, achieving precise tunability over the intermediate features is an important development in controlling mesoscale structure and realizing advanced new forms of soft matter.« less
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Molecular dynamics study of polysaccharides in binary solvent mixtures of an ionic liquid and water.
Liu, Hanbin; Sale, Kenneth L; Simmons, Blake A; Singh, Seema
2011-09-01
Some ionic liquids (ILs) have great promise as effective solvents for biomass pretreatment, and there are several that have been reported that can dissolve large amounts of cellulose. The solubilized cellulose can then be recovered by addition of antisolvents, such as water or ethanol, and this regeneration process plays an important role in the subsequent enzymatic saccharification reactions and in the recovery of the ionic liquid. To date, little is known about the fundamental intermolecular interactions that drive the dissolution and subsequent regeneration of cellulose in complex mixtures of ionic liquids, water, and cellulose. To investigate these interactions, in this work, molecular dynamics (MD) simulations were carried out to study binary and ternary mixtures of the ionic liquid 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]) with water and a cellulose oligomer. Simulations of a cellulose oligomer dissolved in three concentrations of binary mixtures of [C2mim][OAc] and water were used to represent the ternary system in the dissolution phase (high [C2mim][OAc] concentration) and present during the initial phase of the regeneration step (intermediate and low [C2mim][OAc] concentrations). The MD analysis of the structure and dynamics that exist in these binary and ternary mixtures provides information on the key intermolecular interactions between cellulose and [C2mim][OAc] that lead to dissolution of cellulose and the key intermolecular interactions in the intermediate states of cellulose precipitation as a function of water content in the cellulose/IL/water system. The analysis of this intermediate state provides new insight into the molecular driving forces present in this ternary system. © 2011 American Chemical Society
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O'Brien, Megan K; Ahmed, Alaa A
2014-01-01
Physiological and emotional states can affect our decision-making processes, even when these states are seemingly insignificant to the decision at hand. We examined whether posture and postural threat affect decisions in a non-related economic domain. Healthy young adults made a series of choices between economic lotteries in various conditions, including changes in body posture (sitting vs. standing) and changes in elevation (ground level vs. atop a 0.8-meter-high platform). We compared three metrics between conditions to assess changes in risk-sensitivity: frequency of risky choices, and parameter fits of both utility and probability weighting parameters using cumulative prospect theory. We also measured skin conductance level to evaluate physiological response to the postural threat. Our results demonstrate that body posture does not significantly affect decision making. Secondly, despite increased skin conductance level, economic risk-sensitivity was unaffected by increased threat. Our findings indicate that economic choices are fairly robust to the physiological and emotional changes that result from posture or postural threat.
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O’Brien, Megan K.
2014-01-01
Physiological and emotional states can affect our decision-making processes, even when these states are seemingly insignificant to the decision at hand. We examined whether posture and postural threat affect decisions in a non-related economic domain. Healthy young adults made a series of choices between economic lotteries in various conditions, including changes in body posture (sitting vs. standing) and changes in elevation (ground level vs. atop a 0.8-meter-high platform). We compared three metrics between conditions to assess changes in risk-sensitivity: frequency of risky choices, and parameter fits of both utility and probability weighting parameters using cumulative prospect theory. We also measured skin conductance level to evaluate physiological response to the postural threat. Our results demonstrate that body posture does not significantly affect decision making. Secondly, despite increased skin conductance level, economic risk-sensitivity was unaffected by increased threat. Our findings indicate that economic choices are fairly robust to the physiological and emotional changes that result from posture or postural threat. PMID:25083345
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Fernandes, Nikhil; Dallas, Panagiotis; Rodriguez, Robert; Bourlinos, Athanasios B; Georgakilas, Vasilios; Giannelis, Emmanuel P
2010-09-01
We report for the first time an ionic fluid based on hydroxylated fullerenes (fullerols). The ionic fluid was synthesized by neutralizing the fully protonated fullerol with an amine terminated polyethylene/polypropylene oxide oligomer (Jeffamine). The ionic fluid was compared to a control synthesized by mixing the partially protonated form (sodium form) of the fullerols with the same oligomeric amine in the same ratio as in the ionic fluids (20 wt% fullerol). In the fullerol fluid the ionic bonding significantly perturbs the thermal transitions and melting/crystallization behavior of the amine. In contrast, both the normalized heat of fusion and crystallization of the amine in the control are similar to those of the neat amine consistent with a physical mixture of the fullerols/amine with minimal interactions. In addition to differences in thermal behavior, the fullerol ionic fluid exhibits a complex viscoelastic behavior intermediate between the neat Jeffamine (liquid-like) and the control (solid-like).
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NASA Astrophysics Data System (ADS)
Fernandes, Nikhil; Dallas, Panagiotis; Rodriguez, Robert; Bourlinos, Athanasios B.; Georgakilas, Vasilios; Giannelis, Emmanuel P.
2010-09-01
We report for the first time an ionic fluid based on hydroxylated fullerenes (fullerols). The ionic fluid was synthesized by neutralizing the fully protonated fullerol with an amine terminated polyethylene/polypropylene oxide oligomer (Jeffamine®). The ionic fluid was compared to a control synthesized by mixing the partially protonated form (sodium form) of the fullerols with the same oligomeric amine in the same ratio as in the ionic fluids (20 wt% fullerol). In the fullerol fluid the ionic bonding significantly perturbs the thermal transitions and melting/crystallization behavior of the amine. In contrast, both the normalized heat of fusion and crystallization of the amine in the control are similar to those of the neat amine consistent with a physical mixture of the fullerols/amine with minimal interactions. In addition to differences in thermal behavior, the fullerol ionic fluid exhibits a complex viscoelastic behavior intermediate between the neat Jeffamine® (liquid-like) and the control (solid-like).
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Polyelectrolyte layer-by-layer deposition in cylindrical nanopores.
Lazzara, Thomas D; Lau, K H Aaron; Abou-Kandil, Ahmed I; Caminade, Anne-Marie; Majoral, Jean-Pierre; Knoll, Wolfgang
2010-07-27
Layer-by-layer (LbL) deposition of polyelectrolytes within nanopores in terms of the pore size and the ionic strength was experimentally studied. Anodic aluminum oxide (AAO) membranes, which have aligned, cylindrical, nonintersecting pores, were used as a model nanoporous system. Furthermore, the AAO membranes were also employed as planar optical waveguides to enable in situ monitoring of the LbL process within the nanopores by optical waveguide spectroscopy (OWS). Structurally well-defined N,N-disubstituted hydrazine phosphorus-containing dendrimers of the fourth generation, with peripherally charged groups and diameters of approximately 7 nm, were used as the model polyelectrolytes. The pore diameter of the AAO was varied between 30-116 nm and the ionic strength was varied over 3 orders of magnitude. The dependence of the deposited layer thickness on ionic strength within the nanopores is found to be significantly stronger than LbL deposition on a planar surface. Furthermore, deposition within the nanopores can become inhibited even if the pore diameter is much larger than the diameter of the G4-polyelectrolyte, or if the screening length is insignificant relative to the dendrimer diameter at high ionic strengths. Our results will aid in the template preparation of polyelectrolyte multilayer nanotubes, and our experimental approach may be useful for investigating theories regarding the partitioning of nano-objects within nanopores where electrostatic interactions are dominant. Furthermore, we show that the enhanced ionic strength dependence of polyelectrolyte transport within the nanopores can be used to selectively deposit a LbL multilayer atop a nanoporous substrate.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Borkowski, Marian; Richmann, Michael K; Reed, Donald T
2010-01-01
The potential importance of tetraborate complexation on lanthanide(III) and actinide(III) solubility is recognized in the literature but a systematic study of f-element complexation has not been performed. In neodymium solubility studies in WIPP brines, the carbonate complexation effect is not observed since tetraborate ions form a moderately strong complex with neodymium(III). The existence of these tetraborate complexes was established for low and high ionic strength solutions. Changes in neodymium(III) concentrations in undersaturation experiments were used to determine the neodymium with tetraborate stability constants as a function of NaCl ionic strength. As very low Nd(III) concentrations have to be measured, itmore » was necessary to use an extraction pre-concentration step combined with ICP-MS analysis to extend the detection limit by a factor of 50. The determined Nd(III) with borate stability constants at infinite dilution and 25 C are equal to log {beta}{sub 1} = 4.55 {+-} 0.06 using the SIT approach, equal to log {beta}{sub 1} = 4.99 {+-} 0.30 using the Pitzer approach, with an apparent log {beta}{sub 1} = 4.06 {+-} 0.15 (in molal units) at I = 5.6 m NaCl. Pitzer ion-interaction parameters for neodymium with tetraborate and SIT interaction coefficients were also determined and reported.« less
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Lee, Shinbuhm; Zhang, Wenrui; Khatkhatay, Fauzia; ...
2015-09-03
We design and create a unique cell geometry of templated micrometer-thick epitaxial nanocomposite films which contain ~20 nm diameter yttria-stabilized ZrO 2 (YSZ) nanocolumns, strain coupled to a SrTiO 3 matrix. We also enhanced the ionic conductivity of these nanocolumnsby over 2 orders of magnitude compared to plain YSZ films. Concomitant with the higher ionic conduction is the finding that the YSZ nanocolumns in the films have much higher crystallinity and orientation, compared to plain YSZ films. Hence, “oxygen migration highways” are formed in the desired out-of-plane direction. This improved structure is shown to originate from the epitaxial coupling ofmore » the YSZ nanocolumns to the SrTiO 3 film matrix and from nucleation of the YSZ nanocolumns on an intermediate nanocomposite base layer of highly aligned Sm-doped CeO 2 nanocolumns within the SrTiO 3 matrix. Furthermore, this intermediate layer reduces the lattice mismatch between the YSZ nanocolumns and the substrate. Vertical ionic conduction values as high as 10 –2 Ω –1 cm –1 were demonstrated at 360 °C (300 °C lower than plain YSZ films), showing the strong practical potential of these nanostructured films for use in much lower operation temperature ionic devices.« less
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Space Shuttle Enterprise Demate
2012-05-12
NASA and United Space Alliance workers lower a yellow sling onto space shuttle Enterprise, which sits atop NASA's 747 Shuttle Carrier Aircraft (SCA) prior to it being demated a few hours later at John F. Kennedy (JFK) International Airport in New York, Saturday, May 12, 2012. Once the sling was firmly attached early Sunday morning, Enterprise was lifted from the SCA. The shuttle will be placed on a barge that will move by tugboat up the Hudson River to Intrepid in June. The shuttle will be lifted by crane and placed on the flight deck of the Intrepid, where it will be on exhibit to the public starting this summer in a temporary climate-controlled pavilion. Photo Credit: (NASA/Kim Shiflet)
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The Z1 truss is transported to Launch Pad 39A
NASA Technical Reports Server (NTRS)
2000-01-01
At Launch Pad 39A, the payload canister at left draws closer to the Rotating Service Structure where it will be lifted to the Payload Changeout Room. There its cargo, the Integrated Truss Structure Z1, will be removed and later transferred to Space Shuttle Discovery's payload bay. Discovery is at right, sitting atop the Mobile Launcher Platform. The Z1 truss is the first of 10 that will become the backbone of the International Space Station, eventually stretching the length of a football field. Along with its companion payload, the third Pressurized Mating Adapter, the Z1 is scheduled to be launched aboard Discovery Oct. 5 at 9:38 p.m. EDT.
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2002-12-18
KENNEDY SPACE CENTER, FLA. -- A Pegasus XL Expendable Launch Vehicle sits atop a transporter following its arrival in the Multi-Purpose Payload Facility (MPPF) where it will undergo testing, verification, and three flight simulations prior to its scheduled launch. The vehicle, nestled beneath an Orbital Sciences L-1011 aircraft, arrived at the Cape Canaveral Air Force Station Skid Strip on Dec. 17. It is commissioned to carry NASA's Solar Radiation and Climate Experiment (SORCE) spacecraft into orbit in late January 2003. Built by Orbital Sciences Space Systems Group, SORCE will study and measure solar irradiance as a source of energy in the Earth's atmosphere with instruments built by the University of Colorado's Laboratory for Atmospheric and Space Physics (LASP).
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Ionic and Covalent Stabilization of Intermediates and Transition States in Catalysis by Solid Acids
DOE Office of Scientific and Technical Information (OSTI.GOV)
Deshlahra, Prashant; Carr, Robert T.; Iglesia, Enrique
Reactivity descriptors describe catalyst properties that determine the stability of kinetically relevant transition states and adsorbed intermediates. Theoretical descriptors, such as deprotonation energies (DPE), rigorously account for Brønsted acid strength for catalytic solids with known structure. Here, mechanistic interpretations of methanol dehydration turnover rates are used to assess how charge reorganization (covalency) and electrostatic interactions determine DPE and how such interactions are recovered when intermediates and transition states interact with the conjugate anion in W and Mo polyoxometalate (POM) clusters and gaseous mineral acids. Turnover rates are lower and kinetically relevant species are less stable on Mo than W POMmore » clusters with similar acid strength, and such species are more stable on mineral acids than that predicted from W-POM DPE–reactivity trends, indicating that DPE and acid strength are essential but incomplete reactivity descriptors. Born–Haber thermochemical cycles indicate that these differences reflect more effective charge reorganization upon deprotonation of Mo than W POM clusters and the much weaker reorganization in mineral acids. Such covalency is disrupted upon deprotonation but cannot be recovered fully upon formation of ion pairs at transition states. Predictive descriptors of reactivity for general classes of acids thus require separate assessments of the covalent and ionic DPE components. Here, we describe methods to estimate electrostatic interactions, which, taken together with energies derived from density functional theory, give the covalent and ionic energy components of protons, intermediates, and transition states. In doing so, we provide a framework to predict the reactive properties of protons for chemical reactions mediated by ion-pair transition states.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Xiong, Yongliang; Kirkes, Leslie Dawn; Westfall, Terry
In this study, solubility measurements on tri-calcium di-citrate tetrahydrate [Ca 3[C 3H 5O(COO) 3]2•4H 2O, abbreviated as Ca 3[Citrate] 2•4H 2O] as a function of ionic strength are conducted in NaCl solutions up to I = 5.0 mol•kg –1 and in MgCl 2 solutions up to I = 7.5 mol•kg –1, at room temperature (22.5 ± 0.5°C). The solubility constant (log Kmore » $$0\\atop{sp}$$) for Ca 3[Citrate] 2•4H 2O and formation constant (logβ$$0\\atop{1}$$) for Ca[C 3H 5O(COO) 3] –Ca 3[C 3H 5O(COO) 3] 2•4H 2O (earlandite) = 3Ca 2+ + 2[C 3H 5O(COO) 3] 3– + 4H 2O (1) Ca 2+ + [C 3H 5O(COO) 3] 3– = Ca[C 3H 5O(COO) 3] – (2) are determined as –18.11 ± 0.05 and 4.97 ± 0.05, respectively, based on the Pitzer model with a set of Pitzer parameters describing the specific interactions in NaCl and M gCl 2 media.« less
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Aaltonen, T.; Amerio, S.; Amidei, D.; ...
2016-06-28
Here, at the Fermilab Tevatron proton-antiproton (pmore » $$\\bar{p}$$) collider, Drell-Yan lepton pairs are produced in the process p$$\\bar{p}$$→e +e -+X through an intermediate γ*/Z boson. The forward-backward asymmetry in the polar-angle distribution of the e - as a function of the e +e --pair mass is used to obtain sin 2θ$$lept\\atop{eff}$$, the effective leptonic determination of the electroweak-mixing parameter sin2θW. The measurement sample, recorded by the Collider Detector at Fermilab (CDF), corresponds to 9.4 fb -1 of integrated luminosity from p$$\\bar{p}$$ collisions at a center-of-momentum energy of 1.96 TeV, and is the full CDF Run II data set. The value of sin 2θ$$lept\\atop{eff}$$ is found to be 0.23248±0.00053. The combination with the previous CDF measurement based on μ +μ - pairs yields sin 2θ$$lept\\atop{eff}$$=0.23221±0.00046. This result, when interpreted within the specified context of the standard model assuming sin 2θW=1-M$$2\\atop{W}$$/M$$2\\atop{Z}$$ and that the W- and Z-boson masses are on-shell, yields sin 2θW=0.22400±0.00045, or equivalently a W-boson mass of 80.328±0.024 GeV/c 2.« less
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A unified model of Grignard reagent formation.
Shao, Yunqi; Liu, Zhen; Huang, Pan; Liu, Boping
2018-04-25
Grignard reagents are among the most fundamental reagents in organic synthesis, yet studies have hitherto failed to fully explain the selectivity and kinetics of Grignard reagent formation (GRF). The present study provides new insights into the intermediates and pathways of GRF using density functional theory (DFT) calculations. Potential energy surfaces of RX dissociation along different directions reveal the origin of configuration retention of alkenyl and aromatic halides. Radical intermediates participate solely in the dissociation stage, and depend on the geometry of the reactant halide. Dissociation of organic halides yields stabilized surface anions, and the rest of the reaction is ionic in nature. MgX+/RMg+ were proposed as the key intermediates of Mg leaving from the surface in the self-activation of GRF, which explains the accelerated kinetics upon addition of RMgX or MgX2. The intermediacy of the cations was supported by a simple electrochemical experiment. To the best of our knowledge, this is the first unified ionic model (I-model) developed for resolving the controversial issues of GRF.
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Mesoscale studies of ionic closed membranes with polyhedral geometries
2016-07-25
assembled ionic amphiphiles.4 The most commonly observed polyhedral symmetry in self-organized homogeneous structures is the icosahedron, which has the...Possible buckled structures can be obtained considering components A, B with intermediate compositions f of the B component such that the stable shape...lines aids the faceting of the shell into a polyhedral structure often with three-fold vertices. Such vertices are joined together by sharp edges
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Kaon BSM B -parameters using improved staggered fermions from N f = 2 + 1 unquenched QCD
DOE Office of Scientific and Technical Information (OSTI.GOV)
Choi, Benjamin J.
2016-01-28
In this paper, we present results for the matrix elements of the additional ΔS = 2 operators that appear in models of physics beyond the Standard Model (BSM), expressed in terms of four BSM B -parameters. Combined with experimental results for ΔM K and ε K, these constrain the parameters of BSM models. We use improved staggered fermions, with valence hypercubic blocking transfromation (HYP)-smeared quarks and N f = 2 + 1 flavors of “asqtad” sea quarks. The configurations have been generated by the MILC Collaboration. The matching between lattice and continuum four-fermion operators and bilinears is done perturbatively at one-loop order. We use three lattice spacings for the continuum extrapolation: a ≈ 0.09 , 0.06 and 0.045 fm. Valence light-quark masses range down to ≈ mmore » $$phys\\atop{s}$$ /13 while the light sea-quark masses range down to ≈ m$$phys\\atop{s}$$ / 20 . Compared to our previous published work, we have added four additional lattice ensembles, leading to better controlled extrapolations in the lattice spacing and sea-quark masses. We report final results for two renormalization scales, μ = 2 and 3 GeV, and compare them to those obtained by other collaborations. Agreement is found for two of the four BSM B-parameters (B 2 and B$$SUSY\\atop{3}$$ ). The other two (B 4 and B 5) differ significantly from those obtained using regularization independent momentum subtraction (RI-MOM) renormalization as an intermediate scheme, but are in agreement with recent preliminary results obtained by the RBC-UKQCD Collaboration using regularization independent symmetric momentum subtraction (RI-SMOM) intermediate schemes.« less
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2007-08-08
KENNEDY SPACE CENTER, FLA. -- Space Shuttle Endeavour appears to sit atop a long column of smoke as it hurtles into space on mission STS-118. Liftoff from Launch Pad 39A was on time at 6:36 p.m. EDT. The mission is the 22nd shuttle flight to the International Space Station. It will continue space station construction by delivering a third starboard truss segment, S5, and other payloads such as the SPACEHAB module and the external stowage platform 3. The 11-day mission may be extended to as many as 14 depending on the test of the Station-to-Shuttle Power Transfer System that will allow the docked shuttle to draw electrical power from the station and extend its visits to the orbiting lab. NASA/Ken Thornsley
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NASA Technical Reports Server (NTRS)
2005-01-01
KENNEDY SPACE CENTER, FLA. Space Shuttle Discovery lingers at the foot of Launch Pad 39B in the evening twilight. First motion from the Vehicle Assembly Building was at 2:04 p.m. EDT April 6, and the Shuttle was hard down on the pad at 1:16 a.m. EDT April 7. The Shuttle sits atop a Mobile Launcher Platform transported by a Crawler-Transporter underneath. Launch of Discovery on its Return to Flight mission, STS-114, is targeted for May 15 with a launch window that extends to June 3. During its 12-day mission, Discoverys seven-member crew will test new hardware and techniques to improve Shuttle safety, as well as deliver supplies to the International Space Station. Photo courtesy of Scott Andrews.
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Yamamoto, Takaaki; Mitsuno, Koki; Mori, Shigeki; Itoyama, Shuhei; Shiota, Yoshihito; Yoshizawa, Kazunari; Ishida, Masatoshi; Furuta, Hiroyuki
2018-05-07
Complexation of a RuCp* cation with N-confused tetraarylporphyrins (NCPs) forms directly bound ruthenium(II) pentamethylcyclopentadienyl (Cp*) π-complex on a specific meso-aryl group (e.g., phenyl) neighboring peripheral imino nitrogen of NCPs in high yields. In contrast, in the case of NCPs bearing bulky meso-substituents (e.g., 3,5-di-tert-butylphenyl), new ruthenocenophane-like complex embedded on an N-confused calix[4]phyrin was formed through multiple C-H bond activation of methyl groups of Cp* ligand. The mechanistic insight into the formation of the ruthenocenophane was derived from DFT calculations. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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NASA Technical Reports Server (NTRS)
2006-01-01
At least three different kinds of rocks await scientific analysis at the place where NASA's Mars Exploration Rover Spirit will likely spend several months of Martian winter. They are visible in this picture, which the panoramic camera on Spirit acquired during the rover's 809th sol, or Martian day, of exploring Mars (April 12, 2006). Paper-thin layers of light-toned, jagged-edged rocks protrude horizontally from beneath small sand drifts; a light gray rock with smooth, rounded edges sits atop the sand drifts; and several dark gray to black, angular rocks with vesicles (small holes) typical of hardened lava lie scattered across the sand. This view is an approximately true-color rendering that combines images taken through the panoramic camera's 753-nanometer, 535-nanometer, and 432-nanometer filters.
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The Z1 truss is transported to Launch Pad 39A
NASA Technical Reports Server (NTRS)
2000-01-01
At Launch Pad 39A, the payload canister with the Integrated Truss Structure Z1 inside arrives at the spot under the Rotating Service Structure where the canister can be lifted to the Payload Changeout Room. There the Z1 truss will be removed and later transferred to Space Shuttle Discovery's payload bay. Discovery is at right, sitting atop the Mobile Launcher Platform. The Z1 truss is the first of 10 that will become the backbone of the International Space Station, eventually stretching the length of a football field. Along with its companion payload, the third Pressurized Mating Adapter, the Z1 is scheduled to be launched aboard Discovery Oct. 5 at 9:38 p.m. EDT.
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2002-12-18
KENNEDY SPACE CENTER, FLA. -- A Pegasus XL Expendable Launch Vehicle sits atop a transporter following its arrival in the Multi-Purpose Payload Facility (MPPF). Next, it will be moved into a highbay where it will undergo testing, verification, and three flight simulations prior to its scheduled launch. The vehicle, nestled beneath an Orbital Sciences L-1011 aircraft, arrived at the Cape Canaveral Air Force Station Skid Strip on Dec. 17. It is commissioned to carry NASA's Solar Radiation and Climate Experiment (SORCE) spacecraft into orbit in late January 2003. Built by Orbital Sciences Space Systems Group, SORCE will study and measure solar irradiance as a source of energy in the Earth's atmosphere with instruments built by the University of Colorado's Laboratory for Atmospheric and Space Physics (LASP).
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2002-12-18
KENNEDY SPACE CENTER, FLA. -- A Pegasus XL Expendable Launch Vehicle sits atop a transporter following its arrival in the Multi-Purpose Payload Facility (MPPF). Next, it will be moved into a highbay where it will undergo testing, verification, and three flight simulations prior to its scheduled launch. The vehicle, nestled beneath an Orbital Sciences L-1011 aircraft, arrived at the Cape Canaveral Air Force Station Skid Strip on Dec. 17. It is commissioned to carry NASA's Solar Radiation and Climate Experiment (SORCE) spacecraft into orbit in late January 2003. Built by Orbital Sciences Space Systems Group, SORCE will study and measure solar irradiance as a source of energy in the Earth's atmosphere with instruments built by the University of Colorado's Laboratory for Atmospheric and Space Physics (LASP).
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1998-12-29
KENNEDY SPACE CENTER, FLA. -- At Launch Complex 17B, Cape Canaveral Air Station, workers look over the Mars Polar Lander (top) atop the Boeing Delta II rocket as it sits ready for the fairing to be attached. The rocket is scheduled to launch Jan. 3, 1999. The lander is a solar-powered spacecraft designed to touch down on the Martian surface near the northern-most boundary of the south pole in order to study the water cycle there. The lander also will help scientists learn more about climate change and current resources on Mars, studying such things as frost, dust, water vapor and condensates in the Martian atmosphere. It is the second spacecraft to be launched in a pair of Mars Surveyor '98 missions
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Gao, Benlian; Boeglin, William E.; Zheng, Yuxiang; Schneider, Claus; Brash, Alan R.
2009-01-01
Allene oxides are reactive epoxides biosynthesized from fatty acid hydroperoxides by specialized cytochrome P450s or by catalase-related hemoproteins. Here we cloned, expressed, and characterized a gene encoding a lipoxygenase-catalase/peroxidase fusion protein from Acaryochloris marina. We identified novel allene oxide synthase (AOS) activity and a by-product that provides evidence of the reaction mechanism. The fatty acids 18.4ω3 and 18.3ω3 are oxygenated to the 12R-hydroperoxide by the lipoxygenase domain and converted to the corresponding 12R,13-epoxy allene oxide by the catalase-related domain. Linoleic acid is oxygenated to its 9R-hydroperoxide and then, surprisingly, converted ∼70% to an epoxyalcohol identified spectroscopically and by chemical synthesis as 9R,10S-epoxy-13S-hydroxyoctadeca-11E-enoic acid and only ∼30% to the 9R,10-epoxy allene oxide. Experiments using oxygen-18-labeled 9R-hydroperoxide substrate and enzyme incubations conducted in H218O indicated that ∼72% of the oxygen in the epoxyalcohol 13S-hydroxyl arises from water, a finding that points to an ionic intermediate (epoxy allylic carbocation) during catalysis. AOS and epoxyalcohol synthase activities are mechanistically related, with a reacting intermediate undergoing a net hydrogen abstraction or hydroxylation, respectively. The existence of epoxy allylic carbocations in fatty acid transformations is widely implicated although for AOS reactions, without direct experimental support. Our findings place together in strong association the reactions of allene oxide synthesis and an ionic reaction intermediate in the AOS-catalyzed transformation. PMID:19531485
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Methods for conversion of carbohydrates in ionic liquids to value-added chemicals
Zhao, Haibo [The Woodlands, TX; Holladay, Johnathan E [Kennewick, WA; Zhang, Zongchao C [Norwood, NJ
2011-05-10
Methods are described for converting carbohydrates including, e.g., monosaccharides, disaccharides, and polysaccharides in ionic liquids to value-added chemicals including furans, useful as chemical intermediates and/or feedstocks. Fructose is converted to 5-hydroxylmethylfurfural (HMF) in the presence of metal halide and acid catalysts. Glucose is effectively converted to HMF in the presence of chromium chloride catalysts. Yields of up to about 70% are achieved with low levels of impurities such as levulinic acid.
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EXPEDITIOUS SYNTHETIC TRANSFORMATIONS USING MICROWAVES
Microwave-expedited solvent-free synthetic processes will be described for the synthesis of a variety of industrially significant compounds and intermediates namely, enamines, nitroalkenes, enones, oxidized sulfur compounds and ionic liquids. This solvent-free synthetic methodolo...
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Wang, Xiao-Na; Winston-McPherson, Gabrielle N.; Walton, Mary C.; Zhang, Yu
2013-01-01
We describe here details of our investigations into Pd-catalyzed and thermal aza-Claisen–carbocyclizations of N-allyl ynamides to prepare a variety of α,β-unsaturated cyclopentenimines. The nature of the ynamide electron withdrawing group and β-substituent plays critical roles in the success of this tandem cascade. With N-sulfonyl ynamides, the use of palladium catalysis is required, as facile 1,3-sulfonyl shifts dominate under thermal conditions. However, since no analogous 1,3-phosphoryl shift is operational, N-phosphoryl ynamides could be used to prepare similar cyclopentenimines under thermal conditions through zwitter ionic intermediates that undergo N-promoted H-shifts. Alternatively, by employing ynamides bearing tethered carbon nucleophiles, the zwitter ionic intermediates could be intercepted giving rise rapidly to more complex fused bi- and tricyclic scaffolds. PMID:23718841
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Belousov, Valery V
2017-02-21
High temperature electrochemical devices such as solid oxide fuel cells (SOFCs) and oxygen separators based on ceramic materials are used for efficient energy conversion. These devices generally operate in the temperature range of 800-1000 °C. The high operating temperatures lead to accelerated degradation of the SOFC and oxygen separator materials. To solve this problem, the operating temperatures of these electrochemical devices must be lowered. However, lowering the temperature is accompanied by decreasing the ionic conductivity of fuel cell electrolyte and oxygen separator membrane. Therefore, there is a need to search for alternative electrolyte and membrane materials that have high ionic conductivity at lower temperatures. A great many opportunities exist for molten oxides as electrochemical energy materials. Because of their unique electrochemical properties, the molten oxide innovations can offer significant benefits for improving energy efficiency. In particular, the newly developed electrochemical molten oxide materials show high ionic conductivities at intermediate temperatures (600-800 °C) and could be used in molten oxide fuel cells (MOFCs) and molten oxide membranes (MOMs). The molten oxide materials containing both solid grains and liquid channels at the grain boundaries have advantages compared to the ceramic materials. For example, the molten oxide materials are ductile, which solves a problem of thermal incompatibility (difference in coefficient of thermal expansion, CTE). Besides, the outstanding oxygen selectivity of MOM materials allows us to separate ultrahigh purity oxygen from air. For their part, the MOFC electrolytes show the highest ionic conductivity at intermediate temperatures. To evaluate the potential of molten oxide materials for technological applications, the relationship between the microstructure of these materials and their transport and mechanical properties must be revealed. This Account summarizes the latest results on oxygen ion transport in potential MOM materials and MOFC electrolytes. In addition, we consider the rapid oxygen transport in a molten oxide scale formed on a metal surface during catastrophic oxidation and show that the same transport could be used beneficially in MOMs and MOFCs. A polymer model explaining the oxygen transport in molten oxides is also considered. Understanding the oxygen transport mechanisms in oxide melts is important for the development of new generation energy materials, which will contribute to more efficient operation of electrochemical devices at intermediate temperatures. Here we highlight the progress made in developing this understanding. We also show the latest advances made in search of alternative molten oxide materials having high mixed ion electronic and ionic conductivities for use in MOMs and MOFCs, respectively. Prospects for further research are presented.
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2009-03-06
CAPE CANAVERAL, Fla. – After rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B, in Florida, NASA's Kepler spacecraft sits poised for launch atop the United Launch Alliance Delta II 7925 rocket. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller
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2009-03-06
CAPE CANAVERAL, Fla. – After rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B in Florida, NASA's Kepler spacecraft sits poised for launch atop the United Launch Alliance Delta II 7925 rocket. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller
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2009-03-06
CAPE CANAVERAL, Fla. – After rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B in Florida, NASA's Kepler spacecraft sits poised for launch atop the United Launch Alliance Delta II 7925 rocket. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller
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1998-09-28
KENNEDY SPACE CENTER, FLA. -- At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure (FSS), is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar-observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process. At the top of the FSS can be seen the 80-foot lightning mast . The 4-foot-high lightning rod on top helps prevent lightning current from passing directly through the Space Shuttle and the structures on the pad
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Spirit Scans Winter Haven (False Color)
NASA Technical Reports Server (NTRS)
2006-01-01
At least three different kinds of rocks await scientific analysis at the place where NASA's Mars Exploration Rover Spirit will likely spend several months of Martian winter. They are visible in this picture, which the panoramic camera on Spirit acquired during the rover's 809th sol, or Martian day, of exploring Mars (April 12, 2006). Paper-thin layers of light-toned, jagged-edged rocks protrude horizontally from beneath small sand drifts; a light gray rock with smooth, rounded edges sits atop the sand drifts; and several dark gray to black, angular rocks with vesicles (small holes) typical of hardened lava lie scattered across the sand. This view is a false-color rendering that combines images taken through the panoramic camera's 753-nanometer, 535-nanometer, and 432-nanometer filters. -
2008-06-11
CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance
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2008-06-11
CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance
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2008-06-11
CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance
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2008-06-11
CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance
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2005-12-16
KENNEDY SPACE CENTER, FLA. - In the Payload Hazardous Servicing Facility, New Horizons sits atop a transporter awaiting its move to Complex 41 on Cape Canaveral Air Force Station. New Horizons carries seven scientific instruments that will characterize the global geology and geomorphology of Pluto and its moon Charon, map their surface compositions and temperatures, and examine Pluto's complex atmosphere. After that, flybys of Kuiper Belt objects from even farther in the solar system may be undertaken in an extended mission. New Horizons is the first mission in NASA's New Frontiers program of medium-class planetary missions. The spacecraft, designed for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md., will launch aboard a Lockheed Martin Atlas V rocket and fly by Pluto and Charon as early as summer 2015.
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Mechanistic Study of Oxygen Atom Transfer Catalyzed by Rhenium Compounds
DOE Office of Scientific and Technical Information (OSTI.GOV)
Shan, Xiaopeng
2003-01-01
Two ionic and one neutral methyl(oxo)rhenium(V) compounds were synthesized and structurally characterized. They were compared in reactivity towards the ligands triphenylphosphane, pyridines, pyridine N-oxides. Assistance from Broensted bases was found on ligand displacement of ionic rhenium compounds as well as nucleophile assistance on oxidation of all compounds. From the kinetic data, crystal structures, and an analysis of the intermediates, a structural formula of PicH +3 - and mechanisms of ligand displacement and oxidation were proposed.
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NASA Astrophysics Data System (ADS)
Boddohi, Soheil; Killingsworth, Christopher; Kipper, Matt
2008-03-01
Chitosan (a weak polycation) and heparin (a strong polyanion) are used to make polyelectrolyte multilayers (PEM). PEM thickness and composition are determined as a function of solution pH (4.6 to 5.8) and ionic strength (0.1 to 0.5 M). Over this range, increasing pH increases the PEM thickness; however, the sensitivity to changes in pH is a strong function of ionic strength. The PEM thickness data are correlated to the polymer conformation in solution. Polyelectrolyte conformation in solution is characterized by gel permeation chromatography (GPC). The highest sensitivity of PEM structure to pH is obtained at intermediate ionic strength. Different interactions govern the conformation and adsorption phenomena at low and high ionic strength, leading to reduced sensitivity to solution pH at extreme ionic strengths. The correspondence between PEM thickness and polymer solution conformation offers opportunities to tune polymer thin film structure at the nanometer length scale by controlling simple, reproducible processing conditions.
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Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation
Salinas, Branden A; Sathish, Hasige A; Bishop, Steven M; Harn, Nick; Carpenter, John F; Randolph, Theodore W
2014-01-01
Opalescence and high viscosities can pose challenges for high concentration formulation of antibodies. Both phenomena result from protein-protein intermolecular interactions that can be modulated with solution ionic strength. We studied a therapeutic monoclonal antibody that exhibits high viscosity in solutions at low ionic strength (~20 centipoise (cP) at 90 mg/mL and 23°C) and significant opalescence at isotonic ionic strength (approximately 100 nephelometric turbidity units at 90 mg/mL and 23°C). The intermolecular interactions responsible for these effects were characterized using membrane osmometry, static light scattering and zeta potential measurements. The net protein-protein interactions were repulsive at low ionic strength (~4 mM) and attractive at isotonic ionic strengths. The high viscosities are attributed to electroviscous forces at low ionic strength and the significant opalescence at isotonic ionic strength is correlated with attractive antibody interactions. Furthermore there appears to be a connection to critical phenomena and it is suggested that the extent of opalescence is dependent on the proximity to the critical point. We demonstrate that by balancing the repulsive and attractive forces via intermediate ionic strengths and by increasing the mAb concentration above the apparent critical concentration both opalescence and viscosity can be simultaneously minimized. PMID:19475558
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Martinelli, Anna
2014-01-01
The reaction pathway during the formation of silica via a two-component “non-aqueou” sol-gel synthesis is studied by in situ time-resolved Raman spectroscopy. This synthetic route is followed with and without the addition of the protic ionic liquid 1-ethylimidazolium bis(trifluoromethanesulfonyl)imide (C2HImTFSI) in order to investigate its effect on the reaction pathway. We demonstrate that Raman spectroscopy is suitable to discriminate between different silica intermediates, which are produced and consumed at different rates with respect to the point of gelation. We find that half-way to gelation monomers and shorter chains are the most abundant silica species, while the formation of silica rings strongly correlates to the sol-to-gel transition. Thus, curling up of linear chains is here proposed as a plausible mechanism for the formation of small rings. These in turn act as nucleation sites for the condensation of larger rings and thus the formation of the open and polymeric silica network. We find that the protic ionic liquid does not change the reaction pathway per se, but accelerates the cyclization process, intermediated by the faster inclusion of monomeric species. PMID:24743891
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Catalyst containing oxygen transport membrane
Christie, Gervase Maxwell; Wilson, Jamie Robyn; van Hassel, Bart Antonie
2012-12-04
A composite oxygen transport membrane having a dense layer, a porous support layer and an intermediate porous layer located between the dense layer and the porous support layer. Both the dense layer and the intermediate porous layer are formed from an ionic conductive material to conduct oxygen ions and an electrically conductive material to conduct electrons. The porous support layer has a high permeability, high porosity, and a high average pore diameter and the intermediate porous layer has a lower permeability and lower pore diameter than the porous support layer. Catalyst particles selected to promote oxidation of a combustible substance are located in the intermediate porous layer and in the porous support adjacent to the intermediate porous layer. The catalyst particles can be formed by wicking a solution of catalyst precursors through the porous support toward the intermediate porous layer.
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Yang, A S; Honig, B
1994-04-15
A recently developed approach to calculate the pH dependence of protein stability from three-dimensional structure information is applied to the analysis of acid denaturation of sperm whale apomyoglobin. The finite difference Poisson-Boltzmann method is used to calculate pKa values and these are used to obtain titration curves for the folded protein as well as for compact intermediates. The total electrostatic free energy change involved in apomyoglobin unfolding is then evaluated. Calculations are carried out of the unfolding free energy of the native (N) and the compact intermediate (I) of apomyoglobin relative to the unfolded state (U) over a range of pH at various ionic strengths. The contributions from key ionizable groups to the unfolding process are discussed. For the acid-induced partial unfolding of apomyoglobin near pH 5, the transition from N to I is found to be driven by three histidines that are exposed when the B, C, D and E helices unfold. Similarly, the unfolding of the compact intermediate I consisting of the A, G and H helices is driven primarily by a few carboxylic acids with low pKa values in the compact state. This picture is in contrast to the view which attributes acid denaturation to electrostatic repulsion resulting from the build up of positive charge. In fact, charge-charge interactions in myoglobin are found to be attractive at all pH values where the protein unfolds. pH-dependent changes in these interactions contribute to acid denaturation but other electrostatic effects, such as hydrogen bonding and solvation, are important as well. The effect of increasing ionic strength on unfolding is attributed to the decrease of attractive charge-charge interactions which destabilize the N state relative to I, but stabilize the I state relative to U by reducing the pKa shifts of a few critical carboxylic acids. The I state is found to be more stable than U at neutral pH thus accounting for its presence as an intermediate on the protein folding pathway. Our results have implications for the origins of compact intermediates or "molten globule" states.
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Steroid synthesis by primary human keratinocytes; implications for skin disease
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hannen, Rosalind F., E-mail: r.f.hannen@qmul.ac.uk; Michael, Anthony E.; Jaulim, Adil
2011-01-07
Research highlights: {yields} Primary keratinocytes express the steroid enzymes required for cortisol synthesis. {yields} Normal primary human keratinocytes can synthesise cortisol. {yields} Steroidogenic regulators, StAR and MLN64, are expressed in normal epidermis. {yields} StAR expression is down regulated in eczema and psoriatic epidermis. -- Abstract: Cortisol-based therapy is one of the most potent anti-inflammatory treatments available for skin conditions including psoriasis and atopic dermatitis. Previous studies have investigated the steroidogenic capabilities of keratinocytes, though none have demonstrated that these skin cells, which form up to 90% of the epidermis are able to synthesise cortisol. Here we demonstrate that primary humanmore » keratinocytes (PHK) express all the elements required for cortisol steroidogenesis and metabolise pregnenolone through each intermediate steroid to cortisol. We show that normal epidermis and cultured PHK express each of the enzymes (CYP11A1, CYP17A1, 3{beta}HSD1, CYP21 and CYP11B1) that are required for cortisol synthesis. These enzymes were shown to be metabolically active for cortisol synthesis since radiometric conversion assays traced the metabolism of [7-{sup 3}H]-pregnenolone through each steroid intermediate to [7-{sup 3}H]-cortisol in cultured PHK. Trilostane (a 3{beta}HSD1 inhibitor) and ketoconazole (a CYP17A1 inhibitor) blocked the metabolism of both pregnenolone and progesterone. Finally, we show that normal skin expresses two cholesterol transporters, steroidogenic acute regulatory protein (StAR), regarded as the rate-determining protein for steroid synthesis, and metastatic lymph node 64 (MLN64) whose function has been linked to cholesterol transport in steroidogenesis. The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients. Collectively these data show that PHK are capable of extra-adrenal cortisol synthesis, which could be a fundamental pathway in skin biology with implications in psoriasis and atopic dermatitis.« less
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Dispersion relation for hadronic light-by-light scattering: two-pion contributions
Colangelo, Gilberto; Hoferichter, Martin; Procura, Massimiliano; ...
2017-04-27
In our third paper of a series dedicated to a dispersive treatment of the hadronic light-by-light (HLbL) tensor, we derive a partial-wave formulation for two-pion intermediate states in the HLbL contribution to the anomalous magnetic moment of the muon (g - 2) μ, including a detailed discussion of the unitarity relation for arbitrary partial waves. We show that obtaining a final expression free from unphysical helicity partial waves is a subtle issue, which we thoroughly clarify. As a by-product, we obtain a set of sum rules that could be used to constrain future calculations of γ*γ* → ππ. We validate the formalism extensively using the pion-box contribution, defined by two-pion intermediate states with a pion-pole left-hand cut, and demonstrate how the full known result is reproduced when resumming the partial waves. Using dispersive fits to high-statistics data for the pion vector form factor, we provide an evaluation of the full pion box, amore » $$π-box\\atop{μ}$$ =-15.9(2) × 10 -11. As an application of the partial-wave formalism, we present a first calculation of ππ-rescattering effects in HLbL scattering, with γ*γ* → ππ helicity partial waves constructed dispersively using ππ phase shifts derived from the inverse-amplitude method. In this way, the isospin-0 part of our calculation can be interpreted as the contribution of the f0(500) to HLbL scattering in (g - 2) μ. We also argue that the contribution due to charged-pion rescattering implements corrections related to the corresponding pion polarizability and show that these are moderate. Our final result for the sum of pion-box contribution and its S-wave rescattering corrections reads a$$π-box\\atop{μ}$$ + a$$ππ, π-pole LHC\\atop{μ, J=0}$$ = -24(1) × 10 -11.« less
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Dispersion relation for hadronic light-by-light scattering: two-pion contributions
DOE Office of Scientific and Technical Information (OSTI.GOV)
Colangelo, Gilberto; Hoferichter, Martin; Procura, Massimiliano
In our third paper of a series dedicated to a dispersive treatment of the hadronic light-by-light (HLbL) tensor, we derive a partial-wave formulation for two-pion intermediate states in the HLbL contribution to the anomalous magnetic moment of the muon (g - 2) μ, including a detailed discussion of the unitarity relation for arbitrary partial waves. We show that obtaining a final expression free from unphysical helicity partial waves is a subtle issue, which we thoroughly clarify. As a by-product, we obtain a set of sum rules that could be used to constrain future calculations of γ*γ* → ππ. We validate the formalism extensively using the pion-box contribution, defined by two-pion intermediate states with a pion-pole left-hand cut, and demonstrate how the full known result is reproduced when resumming the partial waves. Using dispersive fits to high-statistics data for the pion vector form factor, we provide an evaluation of the full pion box, amore » $$π-box\\atop{μ}$$ =-15.9(2) × 10 -11. As an application of the partial-wave formalism, we present a first calculation of ππ-rescattering effects in HLbL scattering, with γ*γ* → ππ helicity partial waves constructed dispersively using ππ phase shifts derived from the inverse-amplitude method. In this way, the isospin-0 part of our calculation can be interpreted as the contribution of the f0(500) to HLbL scattering in (g - 2) μ. We also argue that the contribution due to charged-pion rescattering implements corrections related to the corresponding pion polarizability and show that these are moderate. Our final result for the sum of pion-box contribution and its S-wave rescattering corrections reads a$$π-box\\atop{μ}$$ + a$$ππ, π-pole LHC\\atop{μ, J=0}$$ = -24(1) × 10 -11.« less
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Guo, Zengjing; Cai, Xiaochun; Xie, Jingyan; Wang, Xiaochen; Zhou, Yu; Wang, Jun
2016-05-25
An ionic copolymer catalyst with nanopores, large surface area, high ionic density, and superior basicity was prepared via the radical copolymerization of amino-functionalized ionic liquid bromide and divinylbenzene, followed with a hydroxyl exchange for removing bromonium. Evaluated in chemical fixation of CO2 with epoxides into cyclic carbonates in the absence of any solvent and basic additive, the nanoporous copolymer catalyst showed high and stable activity, superior to various control catalysts including the halogen-containing analogue. Further, high yields were obtained over a wide scope of substrates including aliphatic long carbon-chain alkyl epoxides and internal epoxide, even under atmospheric pressure and less than 100 °C for the majority of the substrates. On the basis of in situ Fourier transform infrared (FT-IR) investigation and density functional theory (DFT) calculation for the reaction intermediates, we proposed a possible reaction mechanism accounting for the superior catalytic activity of the ionic copolymer. The specifically prepared ionic copolymer material of this work features highly stable, noncorrosive, and sustainable catalysis and, thus, may be a new possibility for efficient chemical fixation of CO2 since it is an environmentally friendly, metal-free solid catalyst.
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STS-89 M.S. Andrew Thomas, Ph.D., participates in TCDT
NASA Technical Reports Server (NTRS)
1998-01-01
STS-89 Mission Specialist Andrew Thomas, Ph.D. gets ready to drive an M-113 armored personnel carrier as part of Terminal Countdown Demonstration Test (TCDT) activities. The TCDT is held at KSC prior to each Space Shuttle flight to provide crews with an opportunity to participate in simulated countdown activities. Standing inside the M-113 is Dr. Thomas while George Hoggard, a training officer with KSC Fire Services, sits atop the vehicle. The STS-89 mission will be the eighth docking of the Space Shuttle with the Russian Space Station Mir. After docking, Dr. Thomas will transfer to the space station, succeeding David Wolf, M.D., who will return to Earth aboard Endeavour. Dr. Thomas will live and work on Mir until June. STS-89 is scheduled for a Jan. 22 liftoff at 9:48 p.m.
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2002-01-01
In this close-up aerial view, the Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m.
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2000-06-30
After tower rollback just before dawn on Launch Pad 36A, Cape Canaveral Air Force Station, NASA’s Tracking and Data Relay Satellite (TDRS-H) sits bathed in spotlights before liftoff atop an Atlas IIA/Centaur rocket. One of three satellites (labeled H, I and J) being built by the Hughes Space and Communications Company, the latest TDRS uses an innovative springback antenna design. A pair of 15-foot-diameter, flexible mesh antenna reflectors fold up for launch, then spring back into their original cupped circular shape on orbit. The new satellites will augment the TDRS system’s existing Sand Ku-band frequencies by adding Ka-band capability. TDRS will serve as the sole means of continuous, high-data-rate communication with the Space Shuttle, with the International Space Station upon its completion, and with dozens of unmanned scientific satellites in low earth orbit
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2000-06-30
After tower rollback just before dawn on Launch Pad 36A, Cape Canaveral Air Force Station, NASA’s Tracking and Data Relay Satellite (TDRS-H) sits bathed in spotlights before liftoff atop an Atlas IIA/Centaur rocket. One of three satellites (labeled H, I and J) being built by the Hughes Space and Communications Company, the latest TDRS uses an innovative springback antenna design. A pair of 15-foot-diameter, flexible mesh antenna reflectors fold up for launch, then spring back into their original cupped circular shape on orbit. The new satellites will augment the TDRS system’s existing Sand Ku-band frequencies by adding Ka-band capability. TDRS will serve as the sole means of continuous, high-data-rate communication with the Space Shuttle, with the International Space Station upon its completion, and with dozens of unmanned scientific satellites in low earth orbit
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1998-01-09
STS-89 Commander Terrence Wilcutt gets ready to train in an M-113 armored personnel carrier as part of Terminal Countdown Demonstration Test (TCDT) activities. The TCDT is held at KSC prior to each Space Shuttle flight to provide crews with an opportunity to participate in simulated countdown activities. Standing inside the M-113 vehicle is Wilcutt while George Hoggard, a training officer with KSC Fire Services, sits atop the armored personnel carrier. The STS-89 mission will be the eighth docking of the Space Shuttle with the Russian Space Station Mir. After docking, STS-89 Mission Specialist Andrew Thomas, Ph.D., will transfer to the space station, succeeding David Wolf, M.D., who will return to Earth aboard Endeavour. Dr. Thomas will live and work on Mir until June. STS-89 is scheduled for a Jan. 22 liftoff at 9:48 p.m
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Payload canister for Discovery is lifted in place for transfer
NASA Technical Reports Server (NTRS)
1998-01-01
At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure (FSS), is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar- observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process. At the top of the FSS can be seen the 80-foot lightning mast . The 4- foot-high lightning rod on top helps prevent lightning current from passing directly through the Space Shuttle and the structures on the pad.
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Electron capture into large-l Rydberg states of multiply charged ions escaping from solid surfaces
NASA Astrophysics Data System (ADS)
Nedeljković, N.; Nedeljković, Lj.; Mirković, M.
2003-07-01
We have investigated the electron capture into large-l Rydberg states of multiply charged ionic projectiles (e.g., the core charges Z=6, 7, and 8) escaping solid surfaces with intermediate velocities (v≈1 a.u.) in the normal emergence geometry. A model of the nonresonant electron capture from the solid conduction band into the moving large angular-momentum Rydberg states of the ions is developed through a generalization of our results obtained previously for the low-l cases (l=0, 1, and 2). The model is based on the two-wave-function dynamics of the Demkov-Ostrovskii type. The electron exchange process is described by a mixed flux through a moving plane (“Firsov plane”), placed between the solid surface and the ionic projectile. Due to low eccentricities of the large-l Rydberg systems, the mixed flux must be evaluated through the whole Firsov plane. It is for this purpose that a suitable asymptotic method is developed. For intermediate ionic velocities and for all relevant values of the principal quantum number n≈Z, the population probability Pnl is obtained as a nonlinear l distribution. The theoretical predictions concerning the ions S VI, Cl VII, and Ar VIII are compared with the available results of the beam-foil experiments.
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A Rapid Monitoring and Evaluation Method of Schistosomiasis Based on Spatial Information Technology.
Wang, Yong; Zhuang, Dafang
2015-12-12
Thanks to Spatial Information Technologies (SITs) such as Remote Sensing (RS) and Geographical Information System (GIS) that are being quickly developed and updated, SITs are being used more widely in the public health field. The use of SITs to study the characteristics of the temporal and spatial distribution of Schistosoma japonicum and to assess the risk of infection provides methods for the control and prevention of schistosomiasis japonica has gradually become a hot topic in the field. The purpose of the present paper was to use RS and GIS technology to develop an efficient method of prediction and assessment of the risk of schistosomiasis japonica. We choose the Yueyang region, close to the east DongTing Lake (Hunan Province, China), as the study area, where a recent serious outbreak of schistosomiasis japonica took place. We monitored and evaluated the transmission risk of schistosomiasis japonica in the region using SITs. Water distribution data were extracted from RS images. The ground temperature, ground humidity and vegetation index were calculated based on RS images. Additionally, the density of oncomelania snails, which are the Schistosoma japonicum intermediate host, was calculated on the base of RS data and field measurements. The spatial distribution of oncomelania snails was explored using SITs in order to estimate the area surrounding the residents with transmission risk of schistosomiasis japonica. Our research result demonstrated: (1) the risk factors for the transmission of schistosomiasis japonica were closely related to the living environment of oncomelania snails. Key factors such as water distribution, ground temperature, ground humidity and vegetation index can be quickly obtained and calculated from RS images; (2) using GIS technology and a RS deduction technique along with statistical regression models, the density distribution model of oncomelania snails could be quickly built; (3) using SITs and analysis with overlaying population distribution data, the range of transmission risk of schistosomiasis japonica of the study area can be quickly monitored and evaluated. This method will help support the decision making for the control and prevention of schistosomiasis and form a valuable application using SITs for the schistosomiasis research.
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Resonance-to-intercombination-line ratios of neonlike ions in the relativistic regime
Panchenko, D.; Beiersdorfer, P.; Hell, N.; ...
2017-06-05
We report measurements of the intensity ratio of the 1s 22s 22pmore » $$5\\atop{1/2}$$3d 3/2→1s 22s 22p 6 resonance line to the 1s 22s 22p$$5\\atop{3/2}$$3d 5/2→1s 22s 22p 6 intercombination line in neonlike Kr 26+ and Mo 32+. The measurements were performed at the EBIT-I electron beam ion trap facility at the Lawrence Livermore National Laboratory and utilized an x-ray microcalorimeter. The measured ratio for Mo 32+ is in four times closer agreement with theoretical predictions than earlier measurements of ions with lower atomic number. Our measurement thus suggests a narrowing of the disagreement with atomic number, which had not been observed in the previously existing data. This implies that the disagreement with theory may be localized to ions within a range of atomic numbers in which intermediate coupling dominates.« less
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Resonance-to-intercombination-line ratios of neonlike ions in the relativistic regime
DOE Office of Scientific and Technical Information (OSTI.GOV)
Panchenko, D.; Beiersdorfer, P.; Hell, N.
We report measurements of the intensity ratio of the 1s 22s 22pmore » $$5\\atop{1/2}$$3d 3/2→1s 22s 22p 6 resonance line to the 1s 22s 22p$$5\\atop{3/2}$$3d 5/2→1s 22s 22p 6 intercombination line in neonlike Kr 26+ and Mo 32+. The measurements were performed at the EBIT-I electron beam ion trap facility at the Lawrence Livermore National Laboratory and utilized an x-ray microcalorimeter. The measured ratio for Mo 32+ is in four times closer agreement with theoretical predictions than earlier measurements of ions with lower atomic number. Our measurement thus suggests a narrowing of the disagreement with atomic number, which had not been observed in the previously existing data. This implies that the disagreement with theory may be localized to ions within a range of atomic numbers in which intermediate coupling dominates.« less
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Catalyst containing oxygen transport membrane
Lane, Jonathan A.; Wilson, Jamie R.; Christie, Gervase Maxwell; Petigny, Nathalie; Sarantopoulos, Christos
2017-02-07
A composite oxygen transport membrane having a dense layer, a porous support layer and an intermediate porous layer located between the dense layer and the porous support layer. Both the dense layer and the intermediate porous layer are formed from an ionic conductive material to conduct oxygen ions and an electrically conductive material to conduct electrons. The porous support layer has a high permeability, high porosity, and a microstructure exhibiting substantially uniform pore size distribution as a result of using PMMA pore forming materials or a bi-modal particle size distribution of the porous support layer materials. Catalyst particles selected to promote oxidation of a combustible substance are located in the intermediate porous layer and in the porous support adjacent to the intermediate porous layer. The catalyst particles can be formed by wicking a solution of catalyst precursors through the porous support toward the intermediate porous layer.
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Huang, Xiaokun; Zhang, Weiyi
2016-01-01
The misfit layered Bi2A2Co2O8 (A = Ca, Sr, Ba) compounds experience an insulator to metal transition as A’s ionic radius increases. This feature is contradictory to the conventional wisdom that larger lattice constant favors insulating rather than metallic state, and is also difficult to be reconciled using the Anderson weak localization theory. In this paper, we show from the first-principles calculation that an insulator-metal transition takes place from a nonmagnetic low-spin state of Co3+ ions to a hexagonally arranged intermediate-spin low-spin mixed-state in CoO2 plane when ionic radius increases from Ca to Ba. The predicted low-spin state of Bi2Ca2Co2O8 and Bi2Sr2Co2O8 and intermediate-spin low-spin mixed-state of Bi2Ba2Co2O8 are consistent not only with their measured transport properties, but also with the magnetic-field suppressed specific-heat peak observed at the transition temperature. In agreement with experiments, strong electronic correlation is required to stabilize the low-spin insulator and intermediate-spin low-spin metal. PMID:27901119
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Huang, Xiaokun; Zhang, Weiyi
2016-11-30
The misfit layered Bi 2 A 2 Co 2 O 8 (A = Ca, Sr, Ba) compounds experience an insulator to metal transition as A's ionic radius increases. This feature is contradictory to the conventional wisdom that larger lattice constant favors insulating rather than metallic state, and is also difficult to be reconciled using the Anderson weak localization theory. In this paper, we show from the first-principles calculation that an insulator-metal transition takes place from a nonmagnetic low-spin state of Co 3+ ions to a hexagonally arranged intermediate-spin low-spin mixed-state in CoO 2 plane when ionic radius increases from Ca to Ba. The predicted low-spin state of Bi 2 Ca 2 Co 2 O 8 and Bi 2 Sr 2 Co 2 O 8 and intermediate-spin low-spin mixed-state of Bi 2 Ba 2 Co 2 O 8 are consistent not only with their measured transport properties, but also with the magnetic-field suppressed specific-heat peak observed at the transition temperature. In agreement with experiments, strong electronic correlation is required to stabilize the low-spin insulator and intermediate-spin low-spin metal.
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2007-02-16
KENNEDY SPACE CENTER, FLA. -- The Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station after the mobile service tower moves away from the pad. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m. Photo credit: NASA/Kim Shiflett
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2007-02-16
KENNEDY SPACE CENTER, FLA. -- The Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station in this aerial view of the launch complex area as the mobile service tower begins to move away. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m. Photo credit: NASA/George Shelton
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2007-02-16
KENNEDY SPACE CENTER, FLA. -- In this close-up aerial view, the Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station as the mobile service tower begins to move away. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m. Photo credit: NASA/George Shelton
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2002-01-01
In this close-up aerial view, the Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station as the mobile service tower moves away from the pad. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m.
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2002-01-01
The Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station in this aerial view of the launch complex area as the mobile service tower begins to move away. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m.
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2007-02-16
KENNEDY SPACE CENTER, FLA. -- The Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station after the mobile service tower moves away from the pad. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m. Photo credit: NASA/Kim Shiflett
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2007-02-16
KENNEDY SPACE CENTER, FLA. -- The Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station after the mobile service tower moves away from the pad. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m. Photo credit: NASA/Kim Shiflett
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2007-02-16
KENNEDY SPACE CENTER, FLA. -- In this close-up aerial view, the Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m. Photo credit: NASA/George Shelton
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2002-01-01
In this close-up aerial view, the Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station as the mobile service tower begins to move away. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m.
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2007-02-16
KENNEDY SPACE CENTER, FLA. -- In this close-up aerial view, the Delta II rocket with the THEMIS spacecraft atop sits ready for launch on Pad 17-B at Cape Canaveral Air Force Station as the mobile service tower moves away from the pad. THEMIS, an acronym for Time History of Events and Macroscale Interactions during Substorms, consists of five identical probes that will track violent, colorful eruptions near the North Pole. This will be the largest number of scientific satellites NASA has ever launched into orbit aboard a single rocket. The THEMIS mission aims to unravel the mystery behind auroral substorms, an avalanche of magnetic energy powered by the solar wind that intensifies the northern and southern lights. The mission will investigate what causes auroras in the Earth’s atmosphere to dramatically change from slowly shimmering waves of light to wildly shifting streaks of bright color. Launch is scheduled for 6:05 p.m. Photo credit: NASA/George Shelton
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Fifty years of allergy: 1965-2015.
Campbell, Dianne E; Mehr, Sam
2015-01-01
The last 50 years in allergy could almost be considered the first 50 years. Over this time period, we have witnessed the emergence of allergy as a subspecialty, have seen and continue to observe a tremendous change in prevalence of allergic disease and have gained insight into the mechanisms that underlie allergic predisposition and disease manifestation. We have improved the care of children with many forms of allergic disease and now sit poised to be able to alter the natural history of allergic disease with the use of specific immunotherapy. There is much left to do in the next 50 years including understanding what underlies both the predisposition to atopic disease and its natural resolution and identifying the environmental cofactors involved in the 'allergic epidemic' and therefore targets for effective primary prevention. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
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WebCIS: large scale deployment of a Web-based clinical information system.
Hripcsak, G; Cimino, J J; Sengupta, S
1999-01-01
WebCIS is a Web-based clinical information system. It sits atop the existing Columbia University clinical information system architecture, which includes a clinical repository, the Medical Entities Dictionary, an HL7 interface engine, and an Arden Syntax based clinical event monitor. WebCIS security features include authentication with secure tokens, authorization maintained in an LDAP server, SSL encryption, permanent audit logs, and application time outs. WebCIS is currently used by 810 physicians at the Columbia-Presbyterian center of New York Presbyterian Healthcare to review and enter data into the electronic medical record. Current deployment challenges include maintaining adequate database performance despite complex queries, replacing large numbers of computers that cannot run modern Web browsers, and training users that have never logged onto the Web. Although the raised expectations and higher goals have increased deployment costs, the end result is a far more functional, far more available system.
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2014-06-20
VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, satellite sits atop a United Launch Alliance Delta II rocket prior to encapsulation in its payload fairing at Space Launch Complex 2 at Vandenberg Air Force Base in California. Launch is scheduled for 2:56 a.m. PDT 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://oco.jpl.nasa.gov Photo credit: NASA/Mark Mackley
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2014-06-20
VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, satellite sits atop a United Launch Alliance Delta II rocket prior to encapsulation in its payload fairing at Space Launch Complex 2 at Vandenberg Air Force Base in California. Launch is scheduled for 2:56 a.m. PDT 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://oco.jpl.nasa.gov Photo credit: NASA/Mark Mackley
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2014-06-20
VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, satellite sits atop a United Launch Alliance Delta II rocket prior to encapsulation in its payload fairing at Space Launch Complex 2 at Vandenberg Air Force Base in California. Launch is scheduled for 2:56 a.m. PDT 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://oco.jpl.nasa.gov Photo credit: NASA/Mark Mackley
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2014-06-20
VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, satellite sits atop a United Launch Alliance Delta II rocket prior to encapsulation in its payload fairing at Space Launch Complex 2 at Vandenberg Air Force Base in California. Launch is scheduled for 2:56 a.m. PDT 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://oco.jpl.nasa.gov Photo credit: NASA/Mark Mackley
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Allergic contact dermatitis caused by cocamide diethanolamine.
Mertens, Sarien; Gilissen, Liesbeth; Goossens, An
2016-07-01
Cocamide DEA (CAS no. 68603-42-9) is a non-ionic surfactant frequently used in industrial, household and cosmetic products for its foam-producing and stabilizing properties. Contact allergy has been reported quite rarely in the past, but recently several cases were published, raising the question of an increase in the frequency of allergic dermatitis caused by this substance. To describe cocamide DEA-allergic patients and their characteristics observed in our department. Medical charts of patients, investigated between 1990 and December 2015, were retrospectively reviewed for cocamide DEA-allergy. Demographic characteristics and patch test results were analyzed. Out of 1767 patients tested, 18 (1%) presented with an allergic reaction to cocamide DEA, all of them at least with hand dermatitis. Twelve patients had (past) occupational exposure to cocamide DEA. Out of the 18 patients, 15 showed (most often) multiple positive reactions and 7 also suffered from atopic dermatitis. Cocamide DEA allergy is relatively rare, despite frequent use, and an increasing trend was not observed. Reactions to cocamidopropyl betaine and cocamide MEA only occurred in some of the subjects tested. Shampoos and liquid hand soaps/cleansers dominated as sources of exposure. All patients presented with an impaired skin barrier due to atopic and/or previous contact dermatitis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Bretti, Clemente; Cigala, Rosalia Maria; Crea, Francesco; De Stefano, Concetta; Vianelli, Giuseppina
2015-10-12
Solubility and acid-base properties of adrenaline were studied in NaCl aqueous solutions at different ionic strengths (0
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Costa, Luciano T; Ribeiro, Mauro C C
2007-10-28
Dynamical properties of polymer electrolytes based on poly(ethylene oxide) (PEO) and ionic liquids of 1-alkyl-3-methylimidazolium cations were calculated by molecular dynamics simulations with previously proposed models [L. T. Costa and M. C. Ribeiro, J. Chem. Phys. 124, 184902 (2006)]. The effect of changing the ionic liquid concentration, temperature, and the 1-alkyl-chain lengths, [1,3-dimethylimidazolium]PF(6) and [1-butyl-3-methylimidazolium]PF(6) ([dmim]PF(6) and [bmim]PF(6)), was investigated. Cation diffusion coefficient is higher than those of anion and oxygen atoms of PEO chains. Ionic mobility in PEO[bmim]PF(6) is higher than in PEO[dmim]PF(6), so that the ionic conductivity kappa of the former is approximately ten times larger than the latter. The ratio between kappa and its estimate from the Nernst-Einstein equation kappa/kappa(NE), which is inversely proportional to the strength of ion pairs, is higher in ionic liquid polymer electrolytes than in polymer electrolytes based on inorganic salts with Li(+) cations. Calculated time correlation functions corroborate previous evidence from the analysis of equilibrium structure that the ion pairs in ionic liquid polymer electrolytes are relatively weak. Structural relaxation at distinct spatial scales is revealed by the calculation of the intermediate scattering function at different wavevectors. These data are reproduced with stretched exponential functions, so that temperature and wavevector dependences of best fit parameters can be compared with corresponding results for polymer electrolytes containing simpler ions.
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XPS studies of Mg doped GDC (Ce0.8Gd0.2O2-δ) for IT-SOFC
NASA Astrophysics Data System (ADS)
Tyagi, Deepak; Rao, P. Koteswara; Wani, B. N.
2018-04-01
Fuel Cells have gained much attention as efficient and environment friendly device for both stationary as well as mobile applications. For intermediate temperature SOFC (IT-SOFC), ceria based electrolytes are the most promising one, due to their higher ionic conductivity at relatively lower temperatures. Gd doped ceria is reported to be having the highest ionic conductivity. In the present work, Mg is codoped along with Gd and the electronic structure of the constituents is studied by XPS. XPS confirm that the Cerium is present in +4 oxidation state only which indicates that electronic conduction can be completely avoided.
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Siqueira, Leonardo J A; Ribeiro, Mauro C C
2006-12-07
The dynamical properties of the polymer electrolyte poly(ethylene oxide) (PEO)LiClO(4) have been investigated by molecular dynamics simulations. The effect of changing salt concentration and temperature was evaluated on several time correlation functions. Ionic displacements projected on different directions reveal anisotropy in short-time (rattling) and long-time (diffusive) dynamics of Li(+) cations. It is shown that ionic mobility is coupled to the segmental motion of the polymeric chain. Structural relaxation is probed by the intermediate scattering function F(k,t) at several wave vectors. Good agreement was found between calculated and experimental F(k,t) for pure PEO. A remarkable slowing down of polymer relaxation is observed upon addition of the salt. The ionic conductivity estimated by the Nernst-Einstein equation is approximately ten times higher than the actual conductivity calculated by the time correlation function of charge current.
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Eco-friendly Energy Storage System: Seawater and Ionic Liquid Electrolyte.
Kim, Jae-Kwang; Mueller, Franziska; Kim, Hyojin; Jeong, Sangsik; Park, Jeong-Sun; Passerini, Stefano; Kim, Youngsik
2016-01-08
As existing battery technologies struggle to meet the requirements for widespread use in the field of large-scale energy storage, novel concepts are urgently needed concerning batteries that have high energy densities, low costs, and high levels of safety. Here, a novel eco-friendly energy storage system (ESS) using seawater and an ionic liquid is proposed for the first time; this represents an intermediate system between a battery and a fuel cell, and is accordingly referred to as a hybrid rechargeable cell. Compared to conventional organic electrolytes, the ionic liquid electrolyte significantly enhances the cycle performance of the seawater hybrid rechargeable system, acting as a very stable interface layer between the Sn-C (Na storage) anode and the NASICON (Na3 Zr2 Si2 PO12) ceramic solid electrolyte, making this system extremely promising for cost-efficient and environmentally friendly large-scale energy storage. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Rigual, Victoria; Santos, Tamara M; Domínguez, Juan Carlos; Alonso, M Virginia; Oliet, Mercedes; Rodriguez, Francisco
2018-03-01
The combination of autohydrolysis and ionic liquid microwave treatments of eucalyptus wood have been studied to facilitate sugar production in a subsequent enzymatic hydrolysis step. Three autohydrolysis conditions (150 °C, 175 °C and 200 °C) in combination with two ionic liquid temperatures (80 °C and 120 °C) were compared in terms of chemical composition, enzymatic digestibility and sugar production. Morphology was measured (using SEM) and the biomass surface was visualized with confocal fluorescence microscopy. The synergistic cooperation of both treatments was demonstrated, enhancing cellulose accessibility. At intermediate autohydrolysis conditions (175 °C) and low ionic liquid temperature (80 °C), a glucan digestibility of 84.4% was obtained. Using SEM micrographs, fractal dimension (as a measure of biomass complexity) and lacunarity (as a measure of homogeneity) were calculated before and after pretreatment. High fractals dimensions and low lacunarities correspond to morphologically complex and homogeneous samples, that are better digested by enzyme cocktails. Copyright © 2017 Elsevier Ltd. All rights reserved.
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NASA Astrophysics Data System (ADS)
Garcia Rey, Natalia; Dlott, Dana
2017-06-01
Imidazolium based ionic liquids (ILs) have been used as a promising system to improve the CO_{2} electroreduction at lower overpotential than other organic or aqueous electrolytes^{1}. Although the detailed mechanism of the CO_{2} electroreduction on Ag has not been elucidated yet, we have developed a methodology to study the electrified interface during the CO_{2} electroreduction using sum frequency generation (SFG) spectroscopy in combination with cyclic voltammetry^{2}. In this work, we tuned the composition of imidazolium-based ILs by exchanging the anion or the functional groups of the imidazolium. We use the nonresonant SFG (NR-SFG) to study the IL-Ag interface and resonant SFG (RES-SFG) to identify the CO adsorbed on the electrode and monitor the Stark shift as a function of cell potential. In previous studies on CO_{2} electroreduction in the IL: 1-ethyl-3-methylimidazolium tetrafluorborate (EMIM-BF_{4}) on Ag, we showed three events occurred at the same potential (-1.33 V vs. Ag/AgCl): the current associated with CO_{2} electroreduction increased, the Stark shift of the adsorbed atop CO doubled in magnitude and the EMIM-BF_{4} underwent a structural transition^{3}. In addition, we also observed how the structural transition of the EMIM-BF_{4} electrolyte shift to lower potentials when the IL is mixed with water. It is known that water enhances the CO_{2} electroreduction producing more CO^{4}. Moreover, the CO is adsorbed in multi-bonded and in atop sites when more water is present in the electrolyte. ^{1}Lau, G. P. S.; Schreier, M.; Vasilyev, D.; Scopelliti, R.; Grätzel, M.; Dyson, P. J., New Insights into the Role of Imidazolium-Based Promoters for the Electroreduction of CO_{2} on a Silver Electrode. J. Am. Chem. Soc. 2016, 138, 7820-7823. ^{2}Garcia Rey, N.; Dlott, D. D., Studies of Electrochemical Interfaces by Broadband Sum Frequency Generation. J. Electroanal. Chem. 2016. DOI:10.1016/j.jelechem.2016.12.023. ^{3}Garcia Rey, N.; Dlott, D. D., Structural Transition in an Ionic Liquid Controls CO_{2} Electrochemical Reduction. J. Phys. Chem. C 2015, 119, 20892-20899. ^{4}Rosen, B. A.; Zhu, W.; Kaul, G.; Salehi-Khojin, A.; Masel, R. I., Water Enhancement of CO_{2} Conversion on Silver in 1-Ethyl-3-Methylimidazolium Tetrafluoroborate. J. Electrochem. Soc. 2013, 160, H138-H141.
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Crea, Francesco; Cucinotta, Daniela; De Stefano, Concetta; Milea, Demetrio; Sammartano, Silvio; Vianelli, Giuseppina
2012-11-20
The total solubility of three penicillin derivatives was determined, in pure water and NaCl aqueous solutions at different salt concentrations (from ∼0.15 to 1.0 mol L(-1) for ampicillin and amoxicillin, and from ∼0.05 to 2.0 mol L(-1) for (+)6-aminopenicillanic acid), using the shake-flask method for generating the saturated solutions, followed by potentiometric analysis. The knowledge of the pH of solubilization and of the protonation constants determined in the same experimental conditions, allowed us to calculate, by means of the mass balance equations, the solubility of the neutral species at different ionic strength values, to model its dependence on the salt concentration and to determine the corresponding values at infinite dilution. The salting parameter and the activity coefficients of the neutral species were calculated by the Setschenow equation. The protonation constants of ampicillin and amoxicillin, determined at different temperatures (from T=288.15 to 318.15K), from potentiometric and spectrophotometric measurements, were used to calculate, by means of the Van't Hoff equation, the temperature coefficients at different ionic strength values and the corresponding protonation entropies. The protonation enthalpies of the (+)6-aminopenicillanic acid were determined by isoperibol calorimetric titrations at T=298.15K and up to I=2.0 mol L(-1). The dependence of the protonation constants on ionic strength was modeled by means of the Debye-Hückel and SIT (Specific ion Interaction Theory) approaches, and the specific interaction parameters of the ionic species were determined. The hydrolysis of the β-lactam ring was studied by spectrophotometric and H NMR investigations as a function of pH, ionic strength and time. Potentiometric measurements carried out on the hydrolyzed (+)6-aminopenicillanic acid allowed us to highlight that the opened and the closed β-lactam forms of the (+)6-aminopenicillanic acid have quite different acid-base properties. An analysis of literature solubility, protonation constants, enthalpies and activity coefficients is reported too. Copyright © 2012 Elsevier B.V. All rights reserved.
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The Spectrum of a Dissociation Intermediate of Cysteine. A Biophysical Chemistry Experiment.
ERIC Educational Resources Information Center
Splittgerber, A. G.; Chinander, L. L.
1988-01-01
Outlines a laboratory exercise that makes use of Beer's Law plots of cysteine constructed at several pH values over a broad range of wavelengths to estimate the tautomeric ratio (R) of two singly charged ionic forms, calculate the microscopic constants, and construct ultraviolet spectra for both light absorbing species. (CW)
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Changes in the Coherent Dynamics of Nanoconfined Room Temperature Ionic Liquids
NASA Astrophysics Data System (ADS)
Vallejo, Kevin; Cano, Melissa; Li, Song; Rotner, Gernot; Faraone, Antonio; Banuelos, Jose
Confinement and temperature effects on the coherent dynamics of the room temperature ionic liquid (RTIL) [C10MPy+] [Tf2N-] were investigated using neutron spin-echo (NSE) in two silica matrices with different pore size. Several intermolecular forces give rise to the bulk molecular structure between anions and cations. NSE provided dynamics (via the coherent intermediate scattering function) in the time range of 0.004 to 10 ns, and at Q-values corresponding to intermediate range ordering and inter- and intra-molecular length scales of the RTIL. Pore wall effects were delineated by comparing bulk RTIL dynamics with those of the confined fluid in 2.8 nm and 8 nm pores. Analytical models were applied to the experimental data to extract decay times and amplitudes of each component. We find a fast relaxation outside the experiment time window, a primary relaxation, and slow, surface-induced dynamics, which all speed up with increased temperature, however, the temperature dependence differs between bulk and confinement. This study sheds light on the structure and dynamics of RTILs and is relevant to the optimization of RTILs for green technologies and applications.
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Advanced intermediate temperature sodium copper chloride battery
NASA Astrophysics Data System (ADS)
Yang, Li-Ping; Liu, Xiao-Min; Zhang, Yi-Wei; Yang, Hui; Shen, Xiao-Dong
2014-12-01
Sodium metal chloride batteries, also called as ZEBRA batteries, possess many merits such as low cost, high energy density and high safety, but their high operation temperature (270-350 °C) may cause several issues and limit their applications. Therefore, decreasing the operation temperature is of great importance in order to broaden their usage. Using a room temperature ionic liquid (RTIL) catholyte composed of sodium chloride buffered 1-ethyl-3-methylimidazolium chloride-aluminum chloride and a dense β″-aluminates solid electrolyte film with 500 micron thickness, we report an intermediate temperature sodium copper chloride battery which can be operated at only 150 °C, therefore alleviating the corrosion issues, improving the material compatibilities and reducing the operating complexities associated with the conventional ZEBRA batteries. The RTIL presents a high ionic conductivity (0.247 S cm-1) at 150 °C and a wide electrochemical window (-2.6 to 2.18 vs. Al3+/Al). With the discharge plateau at 2.64 V toward sodium and the specific capacity of 285 mAh g-1, this intermediate temperature battery exhibits an energy density (750 mWh g-1) comparable to the conventional ZEBRA batteries (728-785 mWh g-1) and superior to commercialized Li-ion batteries (550-680 mWh g-1), making it very attractive for renewable energy integration and other grid related applications.
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Powers, Martha; Saberi, Poune; Pepino, Richard; Strupp, Emily; Bugos, Eva; Cannuscio, Carolyn C
2015-06-01
Pennsylvania sits atop the Marcellus Shale, a reservoir of natural gas that was untapped until the 2004 introduction of unconventional natural gas drilling operations (UNGDO) in the state. Colloquially known as fracking, UNGDO is a controversial process that employs large volumes of water to fracture the shale and capture gas; it has become a multi-billion dollar industry in Pennsylvania. We analyzed letters to the editor of the most widely circulated local newspaper in the most heavily drilled county in Pennsylvania (Bradford County) in order to characterize residents' concerns and their involvement in popular epidemiology--the process by which citizens investigate risks associated with a perceived environmental threat. We reviewed 215 letters to the editor that referenced natural gas operations and were published by The Daily Review between January 1, 2008 and June 8, 2013. We used NVivo 10 to code and analyze letters and identify major themes. Nvivo is qualitative data analysis software (http://www.qsrinternational.com/products_nvivo.aspx) that allows researchers to code and analyze "unstructured" data, including text files of any type (e.g., interview transcripts, news articles, letters, archival materials) as well as photographs and videos. Nvivo can be used to classify, sort, query, comment on, and share data across a research group. Letters demonstrated citizen engagement in beginning and intermediate stages of lay epidemiology, as well as discord and stress regarding four main issues: socio-economic impacts, perceived threats to water, population growth and implications, and changes to the rural landscape. Residents called for stronger scientific evidence and a balance of economic development and health and environmental protections. Citizens' distress regarding UNGDO appeared to be exacerbated by a dearth of information to guide economic growth and health, environmental, and social concerns. This analysis proposes locally informed questions to guide future surveillance and research.
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NASA Astrophysics Data System (ADS)
Fučkar, Neven-Stjepan; Guemas, Virginie; Massonnet, François; Doblas-Reyes, Francisco
2015-04-01
Over the modern observational era, the northern hemisphere sea ice concentration, age and thickness have experienced a sharp long-term decline superimposed with strong internal variability. Hence, there is a crucial need to identify robust patterns of Arctic sea ice variability on interannual timescales and disentangle them from the long-term trend in noisy datasets. The principal component analysis (PCA) is a versatile and broadly used method for the study of climate variability. However, the PCA has several limiting aspects because it assumes that all modes of variability have symmetry between positive and negative phases, and suppresses nonlinearities by using a linear covariance matrix. Clustering methods offer an alternative set of dimension reduction tools that are more robust and capable of taking into account possible nonlinear characteristics of a climate field. Cluster analysis aggregates data into groups or clusters based on their distance, to simultaneously minimize the distance between data points in a given cluster and maximize the distance between the centers of the clusters. We extract modes of Arctic interannual sea-ice variability with nonhierarchical K-means cluster analysis and investigate the mechanisms leading to these modes. Our focus is on the sea ice thickness (SIT) as the base variable for clustering because SIT holds most of the climate memory for variability and predictability on interannual timescales. We primarily use global reconstructions of sea ice fields with a state-of-the-art ocean-sea-ice model, but we also verify the robustness of determined clusters in other Arctic sea ice datasets. Applied cluster analysis over the 1958-2013 period shows that the optimal number of detrended SIT clusters is K=3. Determined SIT cluster patterns and their time series of occurrence are rather similar between different seasons and months. Two opposite thermodynamic modes are characterized with prevailing negative or positive SIT anomalies over the Arctic basin. The intermediate mode, with negative anomalies centered on the East Siberian shelf and positive anomalies along the North American side of the basin, has predominately dynamic characteristics. The associated sea ice concentration (SIC) clusters vary more between different seasons and months, but the SIC patterns are physically framed by the SIT cluster patterns.
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Caufield, Maura; Tom, Wynnis L.
2012-01-01
Background Azathioprine is prescribed as a corticosteroid-sparing agent for many inflammatory conditions, including refractory atopic dermatitis (AD). There is limited prospective data on its appropriate use and monitoring for children with AD. Objectives This study was designed to assess clinical response to azathioprine, determine the necessity for repeat measurement of thiopurine methyltransferase (TPMT) activity during treatment, and test the utility of measuring levels of the metabolites 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP). Methods Twelve children with severe, recalcitrant AD were treated with oral azathioprine and followed prospectively. Disease severity was determined by the SCORing Atopic Dermatitis Index. Baseline TPMT activity was measured and this was repeated along with 6-TGN and 6-MMP measurement at times of stable improvement, inadequate response, or change in response. Results Azathioprine therapy was associated with clinical improvement in all but one subject. There were few adverse effects. Three subjects showed a significant change in TPMT activity during treatment: two had a mild decrease and one demonstrated enzyme inducibility with an increase from the intermediate to the normal activity range. These changes, but not 6-TGN or 6-MMP levels, inversely correlated with the clinical response to therapy. Limitations Small sample size Conclusions Azathioprine can be of benefit in the treatment of recalcitrant pediatric AD. Repeat assessment of TPMT activity may be helpful for evaluation of non–response or change in response and warrants further study. In contrast, measurement of thiopurine metabolites during treatment was not clinically useful. PMID:22892285
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NASA Astrophysics Data System (ADS)
Hardacre, Christopher; Holbrey, John D.; Mullan, Claire L.; Youngs, Tristan G. A.; Bowron, Daniel T.
2010-08-01
The presence of local anisotropy in the bulk, isotropic, and ionic liquid phases—leading to local mesoscopic inhomogeneity—with nanoscale segregation and expanding nonpolar domains on increasing the length of the cation alkyl-substituents has been proposed on the basis of molecular dynamics (MD) simulations. However, there has been little conclusive experimental evidence for the existence of intermediate mesoscopic structure between the first/second shell correlations shown by neutron scattering on short chain length based materials and the mesophase structure of the long chain length ionic liquid crystals. Herein, small angle neutron scattering measurements have been performed on selectively H/D-isotopically substituted 1-alkyl-3-methylimidazolium hexafluorophosphate ionic liquids with butyl, hexyl, and octyl substituents. The data show the unambiguous existence of a diffraction peak in the low-Q region for all three liquids which moves to longer distances (lower Q), sharpens, and increases in intensity with increasing length of the alkyl substituent. It is notable, however, that this peak occurs at lower values of Q (longer length scale) than predicted in any of the previously published MD simulations of ionic liquids, and that the magnitude of the scattering from this peak is comparable with that from the remainder of the amorphous ionic liquid. This strongly suggests that the peak arises from the second coordination shells of the ions along the vector of alkyl-chain substituents as a consequence of increasing the anisotropy of the cation, and that there is little or no long-range correlated nanostructure in these ionic liquids.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Furic, Ivan Kresimir
The measurement of Bmore » $$0\\atop{s}$$ mixing is one of the flagship analyses for the Run II B physics program. The sensitivity of the measurement to the frequency of B$$0\\atop{s}$$ oscillations strongly depends on the number of reconstructed B$$0\\atop{s}$$ mesons. They present the measurement of the ratio of branching fractions Br(B$$0\\atop{s}$$ → D$$-\\atop{s}$$π +)/Br(B 0 → D -π +), which directly influences the number of B$$0\\atop{s}$$ events available for the measurement of B$$0\\atop{s}$$ mixing at CDF-II. They analyze 115 pb -1 of data collected with the CDF-II detector in p$$\\bar{p}$$ collisions at √s = 1.96 TeV using a novel displaced track trigger. They reconstruct 78 ± 11 B$$0\\atop{s}$$ → D$$-\\atop{s}$$π + decays at 1153 ± 45 B 0 → D -π + decays with good signal to background ratio. This is the world's largest sample of fully reconstructed B$$0\\atop{s}$$ → D$$-\\atop{s}$$π + decays. They find the ratio of production fractions multiplied by the ratio of branching fractions to be: f s/f d • Br(B$$0\\atop{s}$$ → D$$-\\atop{s}$$π +)/Br(B 0 → D -π +) = 0.325 ± 0.046(stat) ± 0.034(syst) ± 0.084 (BR). Using the world average value of f s/f d = 0.26 ± 0.03, we infer that the ratio of branching fractions is: Br(B$$0\\atop{s}$$ → D$$-\\atop{s}$$π +)/Br(B 0 → D -π +) = 1.25 ± 0.18(stat) ± 0.13(syst) ± 0.32(BR) ± 0.14(PR) where the last uncertainty is due to the uncertainty on the world average measurement of the ratio of B$$0\\atop{s}$$ to B 0 production rates, f s/f d.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Rieger, Jason
2007-12-08
In a data sample of approximately 1.3 fb -1 collected with the D0 detector between 2002 and 2006, the orbitally excited charm state Dmore » $$±\\atop{s1}$$(2536)has been observed with a measured mass of 2535.7 ± 0.6(stat) ± 0.5(syst) MeV/c 2 via the decay mode B$$0\\atop{s}$$ → D$$-\\atop{s1}$$(2536)μ +vX followed by D$$±\\atop{s1}$$(2536) → D *±K$$0\\atop{S}$$. By normalizing to the known branching ratio Br($$\\bar{b}$$ → D* - μ +vX) and to the number of reconstructed D* mesons with an associated identified muon, a first-ever measurement is made of the product branching ratio ($$\\bar{b}$$ →} D$$-\\atop{s1}$$(2536)μ +vX) • Br(D$$-\\atop{s1}$$ → D* -K$$0\\atop{S}$$). Assuming that D$$-\\atop{s1}$$(2536) production in semileptonic decay is entirely from B$$0\\atop{s}$$, an extraction of the semileptonic branching ratio Br(B$$0\\atop{s}$$ → D$$-\\atop{s1}$$(2536)μ +vX) is made. Comparisons are made with theoretical expectations.« less
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Total Synthesis of Ionic Liquid Systems for Dissolution of Lunar Simulant
NASA Technical Reports Server (NTRS)
Sharpe, Robert J.; Karr, Laurel J.; Paley, Mark S.
2010-01-01
For purposes of Space Resource Utilization, work in the total synthesis of a new ionic liquid system for the extraction of oxygen and metals from lunar soil is studied and described. Reactions were carried out according to procedures found in the chemical literature, analyzed via Thin-Layer Chromatography and 1H Nuclear Magnetic Resonance Spectroscopy and purified via vacuum distillation and rotary evaporation. Upon final analysis via 1H NMR, it was found that while the intermediates of the synthesis had been achieved, unexpected side products were also present. The mechanisms and constraints of the synthesis are described as well as the final results of the project and recommendations for continued study
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Dunes as New Evidence of Recently Active Surface Processes on Pluto
NASA Astrophysics Data System (ADS)
Radebaugh, Jani; Telfer, Matthew; Parteli, Eric; Beyer, Ross A.; Bertrand, Tanguy; Forget, Francois; Nimmo, Francis; Grundy, William M.; Moore, Jeffrey M.; Stern, S. Alan; New Horizons Team
2017-10-01
The surface of Pluto contains hundreds of aligned, regularly spaced features best described as transverse dunes (Telfer et al. in review). They are spaced by 500-700 meters, are several tens of kilometers long, and are subparallel and with a slightly undulatory planform, as seen by the New Horizons LORRI instrument. Their crests are orthogonal to wind streaks seen nearby, and therefore to the assumed regional winds. They sit atop the nitrogen-rich informally named Sputnik Planitia continental glacier at the base of the informally named Al-Idrisi Montes and appear from New Horizons MVIC data to have a composition enriched in methane. Their presence requires there to be particles that can be saltated as well as wind. The particles, or “sands”, are likely composed of relatively hard methane ice, possibly derived from the methane snow seen to blanket the mountain summits. While Pluto’s nitrogen-rich atmosphere fluctuates in density, perhaps dramatically, current modelled conditions allow for winds that are required to saltate the ice sands (<~10 m/s). These features are relatively fresh in appearance, especially in comparison with features farther south that have severe sublimation erosion textures and deformation from glacier flow. Furthermore, they lie atop convection cell margins of Sputnik Planitia, which overturns at rates of ~500 ka. This indicates the dune-like landforms of Pluto are relatively young. This has implications for the surface activity of other large Kuiper Belt Objects and the interaction between limited solar heating and the exotic properties of their surfaces and atmospheres.
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Tepetam, Fatma Merve; Çiftaslan, Nezihe; Oruç, Özlem; Duman, Dildar; Ağca, Meltem; Bulut, İsmet; Çolakoğlu, Bahattin
2016-08-01
Previous hypersensitivity reactions to contrast media (CM), atopy, atopic disease, drug allergy, and age (20-29 or >55) are risk factors for CM hypersensitivity reactions. Our aim was to evaluate whether these risk factors should prompt skin testing for diagnosing CM allergy. The study was conducted among patients referred for allergy testing with CM. Skin tests were performed with non ionic or gadolinium CM, recommended by a radiologist. After completion of tests patients were telephonically queried on their symptoms of reactions. 151 risk patients (53 men, 98 women; mean age 55.2) were included in the study. Only 13 (9 %) had a history of hypersensitivity reaction to CM. Compared with the other patients, atopy was significantly more common in patients with a history of CM hypersensitivity reactions. Female gender and mean age were also higher, but not significant. All of the tests with CMs were negative. Only one patient reported urticaria within 1-2 min after administration of CM (telephonically). Atopy can increase the risk of CM allergy. However, skin tests with CMs may be inefficient, unnecessary, and time-consuming, except in cases with a history of CM allergy. Premedication protocols appear to be beneficial in patients with a history of CM allergy and cannot be recommended for patients with well-controlled asthma, rhinitis, atopic dermatitis or history of drug allergy.
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2000-01-17
One of two new payload transporters for Kennedy Space Center sits on the dock at Port Canaveral. In the background is a cruise ship docked at the Port. The transporters were shipped by barge from their manufacturer, the KAMAG Company of Ulm, Germany. They are used to carry spacecraft and International Space Station elements from payload facilities to and from the launch pads and orbiter hangars. Each transporter is 65 feet long and 22 feet wide and has 24 tires divided between its two axles. The transporter travels 10 miles per hour unloaded, 5 miles per hour when loaded; it weighs up to 172,000 pounds when the canister with payloads rides atop. The transporters will be outfitted with four subsystems for monitoring the environment inside the canister during the payload moves: the Electrical Power System, Environmental Control System, Instrumentation and Communications System, and the Fluids and Gases System. Engineers and technicians are being trained on the transporter's operation and maintenance. The new transporters are replacing the 20-year-old existing Payload Canister Transporter system
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2000-01-17
One of two new payload transporters for Kennedy Space Center sits on the dock at Port Canaveral. In the background is a cruise ship docked at the Port. The transporters were shipped by barge from their manufacturer, the KAMAG Company of Ulm, Germany. They are used to carry spacecraft and International Space Station elements from payload facilities to and from the launch pads and orbiter hangars. Each transporter is 65 feet long and 22 feet wide and has 24 tires divided between its two axles. The transporter travels 10 miles per hour unloaded, 5 miles per hour when loaded; it weighs up to 172,000 pounds when the canister with payloads rides atop. The transporters will be outfitted with four subsystems for monitoring the environment inside the canister during the payload moves: the Electrical Power System, Environmental Control System, Instrumentation and Communications System, and the Fluids and Gases System. Engineers and technicians are being trained on the transporter's operation and maintenance. The new transporters are replacing the 20-year-old existing Payload Canister Transporter system
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2000-01-17
One of two new payload transporters for Kennedy Space Center sits on the dock at Port Canaveral. In the background is a cruise ship docked at the Port. The transporters were shipped by barge from their manufacturer, the KAMAG Company of Ulm, Germany. They are used to carry spacecraft and International Space Station elements from payload facilities to and from the launch pads and orbiter hangars. Each transporter is 65 feet long and 22 feet wide and has 24 tires divided between its two axles. The transporter travels 10 miles per hour unloaded, 5 miles per hour when loaded; it weighs up to 172,000 pounds when the canister with payloads rides atop. The transporters will be outfitted with four subsystems for monitoring the environment inside the canister during the payload moves: the Electrical Power System, Environmental Control System, Instrumentation and Communications System, and the Fluids and Gases System. Engineers and technicians are being trained on the transporter's operation and maintenance. The new transporters are replacing the 20-year-old existing Payload Canister Transporter system
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2000-01-17
One of two new payload transporters for Kennedy Space Center sits on the dock at Port Canaveral. In the background is a cruise ship docked at the Port. The transporters were shipped by barge from their manufacturer, the KAMAG Company of Ulm, Germany. They are used to carry spacecraft and International Space Station elements from payload facilities to and from the launch pads and orbiter hangars. Each transporter is 65 feet long and 22 feet wide and has 24 tires divided between its two axles. The transporter travels 10 miles per hour unloaded, 5 miles per hour when loaded; it weighs up to 172,000 pounds when the canister with payloads rides atop. The transporters will be outfitted with four subsystems for monitoring the environment inside the canister during the payload moves: the Electrical Power System, Environmental Control System, Instrumentation and Communications System, and the Fluids and Gases System. Engineers and technicians are being trained on the transporter's operation and maintenance. The new transporters are replacing the 20-year-old existing Payload Canister Transporter system
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2014-11-04
CAPE CANAVERAL, Fla. – The Orion spacecraft sits inside the Launch Abort System Facility at NASA's Kennedy Space Center in Florida. The Ogive panels have been installed around the launch abort system. The panels will smooth the airflow over the conical spacecraft to limit sound and vibration, which will make for a much smoother ride for the astronauts who will ride inside Orion in the future. The spacecraft is being readied for its move to Space Launch Complex 37 at Cape Canaveral Air Force Station for its flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Jim Grossman
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2014-11-04
CAPE CANAVERAL, Fla. – The Orion spacecraft sits inside the Launch Abort System Facility at NASA's Kennedy Space Center in Florida. The Ogive panels have been installed around the launch abort system. The panels will smooth the airflow over the conical spacecraft to limit sound and vibration, which will make for a much smoother ride for the astronauts who will ride inside Orion in the future. The spacecraft is being readied for its move to Space Launch Complex 37 at Cape Canaveral Air Force Station for its flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Jim Grossman
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2014-11-04
CAPE CANAVERAL, Fla. – The Orion spacecraft sits inside the Launch Abort System Facility at NASA's Kennedy Space Center in Florida. The Ogive panels have been installed around the launch abort system. The panels will smooth the airflow over the conical spacecraft to limit sound and vibration, which will make for a much smoother ride for the astronauts who will ride inside Orion in the future. The spacecraft is being readied for its move to Space Launch Complex 37 at Cape Canaveral Air Force Station for its flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Jim Grossman
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2014-11-04
CAPE CANAVERAL, Fla. – The Orion spacecraft sits inside the Launch Abort System Facility at NASA's Kennedy Space Center in Florida. The Ogive panels have been installed around the launch abort system. The panels will smooth the airflow over the conical spacecraft to limit sound and vibration, which will make for a much smoother ride for the astronauts who will ride inside Orion in the future. The spacecraft is being readied for its move to Space Launch Complex 37 at Cape Canaveral Air Force Station for its flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Jim Grossman
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2014-11-04
CAPE CANAVERAL, Fla. – The Orion spacecraft sits inside the Launch Abort System Facility at NASA's Kennedy Space Center in Florida. The Ogive panels have been installed around the launch abort system. The panels will smooth the airflow over the conical spacecraft to limit sound and vibration, which will make for a much smoother ride for the astronauts who will ride inside Orion in the future. The spacecraft is being readied for its move to Space Launch Complex 37 at Cape Canaveral Air Force Station for its flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Jim Grossman
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2014-11-04
CAPE CANAVERAL, Fla. – The Orion spacecraft sits inside the Launch Abort System Facility at NASA's Kennedy Space Center in Florida. The Ogive panels have been installed around the launch abort system. The panels will smooth the airflow over the conical spacecraft to limit sound and vibration, which will make for a much smoother ride for the astronauts who will ride inside Orion in the future. The spacecraft is being readied for its move to Space Launch Complex 37 at Cape Canaveral Air Force Station for its flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Jim Grossman
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2014-11-04
CAPE CANAVERAL, Fla. – The Orion spacecraft sits inside the Launch Abort System Facility at NASA's Kennedy Space Center in Florida. The Ogive panels have been installed around the launch abort system. The panels will smooth the airflow over the conical spacecraft to limit sound and vibration, which will make for a much smoother ride for the astronauts who will ride inside Orion in the future. The spacecraft is being readied for its move to Space Launch Complex 37 at Cape Canaveral Air Force Station for its flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Jim Grossman
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Seismic evidence for a cold serpentinized mantle wedge beneath Mount St Helens
Hansen, S. M.; Schmandt, B.; Levander, A.; Kiser, E.; Vidale, J. E.; Abers, G. A.; Creager, K. C.
2016-01-01
Mount St Helens is the most active volcano within the Cascade arc; however, its location is unusual because it lies 50 km west of the main axis of arc volcanism. Subduction zone thermal models indicate that the down-going slab is decoupled from the overriding mantle wedge beneath the forearc, resulting in a cold mantle wedge that is unlikely to generate melt. Consequently, the forearc location of Mount St Helens raises questions regarding the extent of the cold mantle wedge and the source region of melts that are responsible for volcanism. Here using, high-resolution active-source seismic data, we show that Mount St Helens sits atop a sharp lateral boundary in Moho reflectivity. Weak-to-absent PmP reflections to the west are attributed to serpentinite in the mantle-wedge, which requires a cold hydrated mantle wedge beneath Mount St Helens (<∼700 °C). These results suggest that the melt source region lies east towards Mount Adams. PMID:27802263
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2009-10-27
CAPE CANAVERAL, Fla. – At Launch Pad 39B at NASA's Kennedy Space Center in Florida, the rotating service structure has been rolled back from the Constellation Program's 327-foot-tall Ares I-X rocket, sitting atop its mobile launcher platform, during preparations for launch. The transfer of the pad from the Space Shuttle Program to the Constellation Program took place May 31. Modifications made to the pad include the removal of shuttle unique subsystems, such as the orbiter access arm and a section of the gaseous oxygen vent arm, and the installation of three 600-foot lightning towers, access platforms, environmental control systems and a vehicle stabilization system. The data returned from more than 700 sensors throughout the rocket will be used to refine the design of future launch vehicles and bring NASA one step closer to reaching its exploration goals. The Ares I-X flight test is targeted for Oct. 27. For information on the Ares I-X vehicle and flight test, visit http://www.nasa.gov/aresIX. Photo credit: NASA/Kim Shiflett
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STS-92 - Towing of Shuttle Discovery and Boeing 747 Shuttle Carrier Aircraft (SCA)
NASA Technical Reports Server (NTRS)
2000-01-01
The Space Shuttle Discovery sits atop one of NASA's modified Boeing 747 Shuttle Carrier Aircraft as the unusual piggyback duo is towed along a taxiway at NASA's Dryden Flight Research Center at Edwards, California. The Discovery was ferried from NASA Dryden to NASA's Kennedy Space Center in Florida on November 2, 2000, after extensive pre-ferry servicing and preparations. STS-92 was the 100th mission since the fleet of four Space Shuttles began flying in 1981. (Due to schedule changes, missions are not always launched in the order that was originally planned.) The almost 13-day mission, the 46th Shuttle mission to land at Edwards, was the last construction mission for the International Space Station prior to the first scientists taking up residency in the orbiting space laboratory the following month. The seven-member crew on STS-92 included mission specialists Koichi Wakata, Michael Lopez-Alegria, Jeff Wisoff, Bill McArthur and Leroy Chiao, pilot Pam Melroy and mission commander Brian Duffy.
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Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Yang, Yang; Liu, Bei; Xu, Jun; Wang, Jinlin; Wu, Jun; Shi, Cheng; Xu, Yaxing; Dong, Jiebin; Wang, Chengyan; Lai, Weifeng; Zhu, Jialiang; Xiong, Liang; Zhu, Dicong; Li, Xiang; Yang, Weifeng; Yamauchi, Takayoshi; Sugawara, Atsushi; Li, Zhongwei; Sun, Fangyuan; Li, Xiangyun; Li, Chen; He, Aibin; Du, Yaqin; Wang, Ting; Zhao, Chaoran; Li, Haibo; Chi, Xiaochun; Zhang, Hongquan; Liu, Yifang; Li, Cheng; Duo, Shuguang; Yin, Ming; Shen, Huan; Belmonte, Juan Carlos Izpisua; Deng, Hongkui
2017-04-06
Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of developmental potency and are characterized by their ability to generate all cell types of an adult organism. However, PSCs show limited contribution to the extraembryonic placental tissues in vivo. Here, we show that a chemical cocktail enables the derivation of stem cells with unique functional and molecular features from mice and humans, designated as extended pluripotent stem (EPS) cells, which are capable of chimerizing both embryonic and extraembryonic tissues. Notably, a single mouse EPS cell shows widespread chimeric contribution to both embryonic and extraembryonic lineages in vivo and permits generating single-EPS-cell-derived mice by tetraploid complementation. Furthermore, human EPS cells exhibit interspecies chimeric competency in mouse conceptuses. Our findings constitute a first step toward capturing pluripotent stem cells with extraembryonic developmental potentials in culture and open new avenues for basic and translational research. VIDEO ABSTRACT. Copyright © 2017 Elsevier Inc. All rights reserved.
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Simulation of 6 to 3 to 1 merge and squeeze of Au77+ bunches in AGS
DOE Office of Scientific and Technical Information (OSTI.GOV)
Gardner, C. J.
2016-05-09
In order to increase the intensity per Au77+ bunch at AGS extraction, a 6 to 3 to 1 merge scheme was developed and implemented by K. Zeno during the 2016 RHIC run. For this scheme, 12 Booster loads, each consisting of a single bunch, are delivered to AGS per AGS magnetic cycle. The bunch from Booster is itself the result of a 4 to 2 to 1 merge which is carried out on a flat porch during the Booster magnetic cycle. Each Booster bunch is injected into a harmonic 24 bucket on the AGS injection porch. In order to fitmore » into the buckets and allow for the AGS injection kicker rise time, the bunch width must be reduced by exciting quadrupole oscillations just before extraction from Booster. The bunches are injected into two groups of six adjacent harmonic 24 buckets. In each group the 6 bunches are merged into 3 by bringing on RF harmonic 12 while reducing harmonic 24. This is a straightforward 2 to 1 merge (in which two adjacent bunches are merged into one). One ends up with two groups of three adjacent bunches sitting in harmonic 12 buckets. These bunches are accelerated to an intermediate porch for further merging. Doing the merge on a porch that sits above injection energy helps reduce losses that are believed to be due to the space-charge force acting on the bunched particles. (The 6 to 3 merge is done on the injection porch because the harmonic 24 frequency on the intermediate porch would be too high for the AGS RF cavities.) On the intermediate porch each group of 3 bunches is merged into one by bringing on RF harmonics 8 and 4 and then reducing harmonics 12 and 8. One ends up with 2 bunches, each the result of a 6 to 3 to 1 merge and each sitting in a harmonic 4 bucket. This puts 6 Booster loads into each bunch. Each merged bunch needs to be squeezed into a harmonic 12 bucket for subsequent acceleration. This is done by again bringing on harmonic 8 and then harmonic 12. Results of simulations of the 6 to 3 to 1 merge and the subsequent squeeze into harmonic 12 buckets are presented in this note. In particular, they provide a benchmark for what can be achieved with the available RF voltages.« less
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Characterization of Intermediate Oxidation States in CO2 Activation
NASA Astrophysics Data System (ADS)
Dodson, Leah G.; Thompson, Michael C.; Weber, J. Mathias
2018-04-01
Redox chemistry during the activation of carbon dioxide involves changing the charge state in a CO2 molecular unit. However, such changes are usually not well described by integer formal charges, and one can think of COO functional units as being in intermediate oxidation states. In this article, we discuss the properties of CO2 and CO2-based functional units in various charge states. Besides covering isolated CO2 and its ions, we describe the CO2-based ionic species formate, oxalate, and carbonate. Finally, we provide an overview of CO2-based functional groups and ligands in clusters and metal-organic complexes.
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The role of electrostatics in protein-protein interactions of a monoclonal antibody.
Roberts, D; Keeling, R; Tracka, M; van der Walle, C F; Uddin, S; Warwicker, J; Curtis, R
2014-07-07
Understanding how protein-protein interactions depend on the choice of buffer, salt, ionic strength, and pH is needed to have better control over protein solution behavior. Here, we have characterized the pH and ionic strength dependence of protein-protein interactions in terms of an interaction parameter kD obtained from dynamic light scattering and the osmotic second virial coefficient B22 measured by static light scattering. A simplified protein-protein interaction model based on a Baxter adhesive potential and an electric double layer force is used to separate out the contributions of longer-ranged electrostatic interactions from short-ranged attractive forces. The ionic strength dependence of protein-protein interactions for solutions at pH 6.5 and below can be accurately captured using a Deryaguin-Landau-Verwey-Overbeek (DLVO) potential to describe the double layer forces. In solutions at pH 9, attractive electrostatics occur over the ionic strength range of 5-275 mM. At intermediate pH values (7.25 to 8.5), there is a crossover effect characterized by a nonmonotonic ionic strength dependence of protein-protein interactions, which can be rationalized by the competing effects of long-ranged repulsive double layer forces at low ionic strength and a shorter ranged electrostatic attraction, which dominates above a critical ionic strength. The change of interactions from repulsive to attractive indicates a concomitant change in the angular dependence of protein-protein interaction from isotropic to anisotropic. In the second part of the paper, we show how the Baxter adhesive potential can be used to predict values of kD from fitting to B22 measurements, thus providing a molecular basis for the linear correlation between the two protein-protein interaction parameters.
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Jernelöv, Susanna; Höglund, Caroline Olgart; Axelsson, John; Axén, Jennie; Grönneberg, Reidar; Grunewald, Johan; Stierna, Pontus; Lekander, Mats
2009-01-01
Recent findings indicate that atopics may be more vulnerable to stress than non-atopics. However, the roles of psychological well-being and sleep in this presumed increased sensitivity are not known. To investigate the effects of a brief naturalistic stressor on psychological responses, sleep, and allergic symptoms and to compare those responses between atopic and non-atopic individuals. We assessed atopic and non-atopic students during a period without and during a period with examinations. For both atopic and non-atopic students, tension, anxiety, and depression deteriorated in response to examination, as did sleep latency and sleep quality. Overall, atopics were more tense, had more anxiety, longer sleep latencies, and were less well rested than non-atopics. Non-atopic students rose from bed later during the examination period. In response to examination, atopic students reported increased frequency of stress behaviors (e.g., eating fast), while decreased stress behaviors were reported by non-atopic students. Allergic symptoms were not affected. Atopic students were worse off in aspects of psychological well-being and sleep, but displayed only partly stronger responses to a stressor compared to non-atopic students. In spite of a broad negative response to examination, allergic symptoms were not affected.
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Angell, C Austen [Mesa, AZ; Xu, Wu [Broadview Heights, OH; Belieres, Jean-Philippe [Chandler, AZ; Yoshizawa, Masahiro [Tokyo, JP
2011-01-11
Disclosed are developments in high temperature fuel cells including ionic liquids with high temperature stability and the storage of inorganic acids as di-anion salts of low volatility. The formation of ionically conducting liquids of this type having conductivities of unprecedented magnitude for non-aqueous systems is described. The stability of the di-anion configuration is shown to play a role in the high performance of the non-corrosive proton-transfer ionic liquids as high temperature fuel cell electrolytes. Performance of simple H.sub.2(g) electrolyte/O.sub.2(g) fuel cells with the new electrolytes is described. Superior performance both at ambient temperature and temperatures up to and above 200.degree. C. are achieved. Both neutral proton transfer salts and the acid salts with HSO.sup.-.sub.4 anions, give good results, the bisulphate case being particularly good at low temperatures and very high temperatures. The performance of all electrolytes is improved by the addition of a small amount of involatile base of pK.sub.a value intermediate between those of the acid and base that make the bulk electrolyte. The preferred case is the imidazole-doped ethylammonium hydrogensulfate which yields behavior superior in all respects to that of the industry standard phosphoric acid electrolyte.
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Hydrodynamic model of temperature change in open ionic channels.
Chen, D P; Eisenberg, R S; Jerome, J W; Shu, C W
1995-01-01
Most theories of open ionic channels ignore heat generated by current flow, but that heat is known to be significant when analogous currents flow in semiconductors, so a generalization of the Poisson-Nernst-Planck theory of channels, called the hydrodynamic model, is needed. The hydrodynamic theory is a combination of the Poisson and Euler field equations of electrostatics and fluid dynamics, conservation laws that describe diffusive and convective flow of mass, heat, and charge (i.e., current), and their coupling. That is to say, it is a kinetic theory of solute and solvent flow, allowing heat and current flow as well, taking into account density changes, temperature changes, and electrical potential gradients. We integrate the equations with an essentially nonoscillatory shock-capturing numerical scheme previously shown to be stable and accurate. Our calculations show that 1) a significant amount of electrical energy is exchanged with the permeating ions; 2) the local temperature of the ions rises some tens of degrees, and this temperature rise significantly alters for ionic flux in a channel 25 A long, such as gramicidin-A; and 3) a critical parameter, called the saturation velocity, determines whether ionic motion is overdamped (Poisson-Nernst-Planck theory), is an intermediate regime (called the adiabatic approximation in semiconductor theory), or is altogether unrestricted (requiring the full hydrodynamic model). It seems that significant temperature changes are likely to accompany current flow in the open ionic channel. PMID:8599638
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Identification of chronic rhinosinusitis phenotypes using cluster analysis.
Soler, Zachary M; Hyer, J Madison; Ramakrishnan, Viswanathan; Smith, Timothy L; Mace, Jess; Rudmik, Luke; Schlosser, Rodney J
2015-05-01
Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. Unsupervised clustering can be used to identify phenotypic subgroups of CRS patients, describe clinical differences in these clusters and define simple algorithms for classification. A multi-institutional, prospective study of 382 patients with CRS who had failed initial medical therapy completed the Sino-Nasal Outcome Test (SNOT-22), Rhinosinusitis Disability Index (RSDI), Medical Outcomes Study Short Form-12 (SF-12), Pittsburgh Sleep Quality Index (PSQI), and Patient Health Questionnaire (PHQ-2). Objective measures of CRS severity included Brief Smell Identification Test (B-SIT), CT, and endoscopy scoring. All variables were reduced and unsupervised hierarchical clustering was performed. After clusters were defined, variations in medication usage were analyzed. Discriminant analysis was performed to develop a simplified, clinically useful algorithm for clustering. Clustering was largely determined by age, severity of patient reported outcome measures, depression, and fibromyalgia. CT and endoscopy varied somewhat among clusters. Traditional clinical measures, including polyp/atopic status, prior surgery, B-SIT and asthma, did not vary among clusters. A simplified algorithm based upon productivity loss, SNOT-22 score, and age predicted clustering with 89% accuracy. Medication usage among clusters did vary significantly. A simplified algorithm based upon hierarchical clustering is able to classify CRS patients and predict medication usage. Further studies are warranted to determine if such clustering predicts treatment outcomes. © 2015 ARS-AAOA, LLC.
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Ionic liquids as an electrolyte for the electro synthesis of organic compounds.
Kathiresan, Murugavel; Velayutham, David
2015-12-25
The use of ionic liquids (ILs) as a solvent and an electrolyte for electro organic synthesis has been reviewed. To date several ILs exist, however the ILs based on tetraalkylammonium, pyrrolidinium, piperidinium and imidazolium cations with BF4(-), PF6(-), and TFSI anions have been widely used and explored the most. Electro organic synthesis in ionic liquid media leading to the synthesis of a wide range of organic compounds has been discussed. Anodic oxidation or cathodic reduction will generate radical cation or anion intermediates, respectively. These radicals can undergo self coupling or coupling with other molecules yielding organic compounds of interest. The cation of the IL is known to stabilize the radical anion extensively. This stabilization effect has a specific impact on the electrochemical CO2 reduction and coupling to various organics. The relative stability of the intermediates in IL leads to the formation of specific products in higher yields. Electrochemical reduction of imidazolium or thiazolium based ILs generates N-heterocyclic carbenes that have been shown to catalyze a wide range of base or nucleophile catalyzed organic reactions in IL media, an aspect that falls into the category of organocatalysis. Electrochemical fluorination or selective electrochemical fluorination is another fascinating area that delivers selectively fluorinated organic products in Et3N·nHF or Et4NF·nHF adducts (IL) via anodic oxidation. Oxidative polymerization in ILs has been explored the most; although morphological changes were observed compared to the conventional methods, polymers were obtained in good yields and in some cases ILs were used as dopants to improve the desired properties.
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Dalitz plot analysis of the decay B 0 ( B ¯ 0 ) → K ± π ∓ π 0
Aubert, B.; Bona, M.; Karyotakis, Y.; ...
2008-09-12
Here, we report a Dalitz-plot analysis of the charmless hadronic decays of neutral B mesons to K ± π ∓ π 0 . With a sample of ( 231.8 ± 2.6 ) × 10 6 Υ ( 4 S ) → Bmore » $$\\bar{B}$$ decays collected by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC, we measure the magnitudes and phases of the intermediate resonant and nonresonant amplitudes for B 0 and $$\\bar{B}$$ 0 decays and determine the corresponding C P -averaged branching fractions and charge asymmetries. Furthermore, we measure the inclusive branching fraction and C P -violating charge asymmetry and found it to be B ( B 0 → K + π - π 0 ) = ( 35.7$$+2.6\\atop{-1.5}$$ + 2.6 - 1.5 ± 2.2 ) × 10 - 6 and A C P = - 0.030 $$+ 0.045\\atop{- 0.051}$$ ± 0.055 where the first errors are statistical and the second systematic. We observe the decay B 0 → K * 0 ( 892 ) π 0 with the branching fraction B ( B 0 → K * 0 ( 892 ) π 0 ) = ( 3.6 $$+ 0.7\\atop- {0.8}$$ ± 0.4 ) × 10 - 6 . This measurement differs from zero by 5.6 standard deviations (including the systematic uncertainties). The selected sample also contains B 0 → $$\\bar{D}$$ 0 π 0 decays where $$\\bar{D}$$ 0 → K + π - , and we measure B ( B 0 → $$\\bar{D}$$ 0π 0 ) = ( 2.93 ± 0.17 ± 0.18 ) × 10 - 4 .« less
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Błażewicz, Izabela; Jaśkiewicz, Maciej; Piechowicz, Lidia; Neubauer, Damian; Nowicki, Roman J; Kamysz, Wojciech; Barańska-Rybak, Wioletta
2017-12-01
Daptomycin is a cyclic lipopeptide that is bactericidal against Staphylococcus aureus , including methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) strains. Daptomycin exerts its antimicrobial effect by a calcium-dependent interaction with the cytoplasmic membrane resulting in depolarization, ion loss and rapid cell death. Unfortunately, loss of daptomycin susceptibility in S. aureus in the clinical setting has been noted. To evaluate the susceptibility profile to daptomycin among S. aureus strains isloted from patients with atopic dermatitis (AD). Another point was to correlate the results obtained by broth microdilution method and Etest, which is commonly applied in clinical setting. One hundred patients with the diagnosis of atopic dermatitis were microbiologically assessed for the carriage of S. aureus . Antimicrobial susceptibility tests were performed using broth-microdilution (BMD) and Etests for daptomycin. Staphylococcus aureus strains were isolated from the majority of our patients, either from the skin (73%) or the anterior nares (75%). Six of the 100 nasal swabs (6%) and 5 of the 100 skin swabs (5%) were positive for methicillin-resistant Staphylococcus aureus (MRSA). A total of 81 of 148 (54.7%) daptomycin non-susceptible isolates of S. aureus were identified by BMD. Only 19 of 81 were also classified as non-susceptible by Etest. Clinicians and microbiologists should be aware of the possibility of the emergence of daptomycin non-susceptibility (or increase in minimal inhibitory concentration) during prolonged therapy and closely monitor the susceptibility of persisting isolates that might be recovered during therapy.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Di Giovanni, Gian Piero
2008-01-01
The two analyses presented in the thesis, the Bmore » $$0\\atop{s}$$ mixing analysis and the B$$0\\atop{s}$$ → J/ψφ angular analysis, share most of the technical implementations and features. Thus, my choice was to pursue in parallel the common aspects of the analyses, avoiding, whenever possible, repetitions. Each Chapter is split in two parts, the first one dedicated to the B$$0\\atop{s}$$ mixing analysis and the second one describing the angular analysis on the B$$0\\atop{s}$$ → J/ψφ decay mode. They are organized as follows. In Chapter 1 we present the theoretical framework of the B$$0\\atop{s}$$ neutral mesons system. After a general introduction on the Standard Model, we focus on the quantities which are relevant to the Δms measurement and the CP violation phenomena, underlying the details concerning the study of pseudo-scalar to vector vector decays, P → VV, which allow to carry out an angular analysis. A discussion on the implication of the measurements performed in the search of physics beyond the Standard Model is presented. The accelerator facilities and the CDF-II detector are reported in Chapter 2. While describing the detector, more emphasis is given to the components fundamental to perform B physics analyses at CDF. The Chapter 3 is focused on the reconstruction and selection of the data samples. The Chapter starts with a description of the on-line trigger requirements, according to the B$$0\\atop{s}$$ sample considered, followed by the offline selection criteria implemented to reconstruct B$$0\\atop{s}$$ semileptonic and hadronic decays, fully and partially reconstructed, for the B$$0\\atop{s}$$ mixing analysis, as well as the B$$0\\atop{s}$$ → J/ψφ decay mode for the angular analysis. The subsequent Chapter 4 is dedicated to the revision of the technical ingredients needed in the final analyses. The B$$0\\atop{s}$$ mixing elements are firstly described. The methodology historically used in the oscillation searches, the 'amplitude scan', is here introduced together with the calibration of the proper-decay-time resolution and the flavor tagging algorithms, in particular a closer examination of the same-side tagger performances is given. The B$$0\\atop{s}$$ → J/ψφ angular analysis elements description then follows, focusing on the performances and the eventual differences with respect to the B$$0\\atop{s}$$ oscillation search. The final results of the analyses are obtained with the use of an un-binned likelihood fitting framework: Chapter 5 presents the general principles behind this methodology and a description of both the maximum likelihood fitters employed. Chapter 6 contains the conclusive results on the B$$0\\atop{s}$$ analyses. They are presented in an historical fashion: the measurement of the B$$0\\atop{s}$$ oscillation frequency is followed by the first flavor tagged ΔΓs and βs measurements. The impact and the constraints on the parameters of the flavor model is part of the discussion in the Chapter. As cross-check of the B$$0\\atop{s}$$ angular analysis, the B$$0\\atop{s}$$ → J/ψK*0 decay mode has been additionally studied. Its angular analysis shows a competitive sensitivity with the B factories in measuring the parameters which define the decay. Not only this contributes to enforce the reliability of the entire framework, but it constitutes an excellent result by itself. Thus, we devote the entire Chapter 7 to the sole discussion of the angular analysis of the B$$0\\atop{s}$$ → J/ψK*0 decay mode.« less
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Smart, J M; Tang, M L K; Kemp, A S
2002-11-01
Reduced Th1 and elevated Th2 cytokine responses are considered to be a principal mechanism in the generation of the inflammation leading to the manifestations of atopic disease in the skin of atopic dermatitis and in the airways of asthma. If reduced Th1 and elevated Th2 responses are principal determinants of the manifestation of atopic disease it might be expected that subjects with established disease would exhibit differences in their cytokine profiles as compared with atopic patients without clinical disease. To determine whether asymptomatic atopic children exhibit a cytokine imbalance similar to that seen in patients with established atopic disease or if they behave like non-atopic controls. Cytokine responses in a group of children with elevated IgE but no clinical manifestations of disease, atopic children with established disease and non-atopic controls were compared. We examined allergen-induced (house dust mite, HDM, rye grass pollen and RYE) cytokine responses in parallel with polyclonal (staphylococcal enterotoxin B, SEB) cytokine responses in a group of children with elevated serum IgE levels without current or past evidence of atopic disease (median age 6.6 years) and compared these with a non-atopic control group (median age 6.5 years) and a group of children with atopic disease (median age 6.7 years). Symptomatic atopic children had reduced SEB-induced IFN-gamma and increased SEB-induced IL-4 and IL-5 as compared with non-atopic controls. In contrast, SEB-induced IFN-gamma, IL-4 and IL-5 production in asymptomatic atopics was not significantly different from the non-atopic control subjects. Allergen-induced Th1 (IFN-gamma) and Th2 (IL-5 and IL-13) cytokine production was increased in both symptomatic atopics and asymptomatic atopics when compared with non-atopic controls. The defect in polyclonally induced IFN-gamma production was associated with the clinical manifestation of atopic disease but not the atopic stateper se. This suggests that the global reduction in IFN-gamma is the key determinant of the development of overt atopic disease. In contrast, elevated allergen-induced Th2 cytokine responses in children related to the atopic state per se irrespective of the presence of clinical atopic disease.
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Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...
2016-12-13
By analyzing 2.93 fb-1 of data taken at the ψ (3770) resonance peak with the BESIII detector, we measure the branching fractions for the hadronic decays D +→Kmore » $$0\\atop{S}$$K$$0\\atop{S}$$K +, D +→K$$0\\atop{S}$$K$$0\\atop{S}$$π +. D 0→K$$0\\atop{S}$$K$$0\\atop{S}$$ and D 0→K$$0\\atop{S}$$K$$0\\atop{S}$$K$$0\\atop{S}$$.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Ablikim, M.; Achasov, M. N.; Ahmed, S.
By analyzing 2.93 fb-1 of data taken at the ψ (3770) resonance peak with the BESIII detector, we measure the branching fractions for the hadronic decays D +→Kmore » $$0\\atop{S}$$K$$0\\atop{S}$$K +, D +→K$$0\\atop{S}$$K$$0\\atop{S}$$π +. D 0→K$$0\\atop{S}$$K$$0\\atop{S}$$ and D 0→K$$0\\atop{S}$$K$$0\\atop{S}$$K$$0\\atop{S}$$.« less
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Aaboud, M.; Aad, G.; Abbott, B.; ...
2017-12-15
A search for pair production of a scalar partner of the top quark in events with four or more jets plus missing transverse momentum is presented. Here, an analysis of 36.1 fb -1 ofmore » $$ \\sqrt{s}=13 $$ TeV proton-proton collisions collected using the ATLAS detector at the LHC yields no significant excess over the expected Standard Model background. To interpret the results a simplified supersymmetric model is used where the top squark is assumed to decay via $$\\sim\\atop{t}$$ 1→t(*)$$\\sim\\atop{χ}$$ $$0\\atop{1}$$ and $$\\sim\\atop{t}$$ 1→b$$\\sim\\atop{χ}$$ $$±\\atop{1}$$→bW(*)$$\\sim\\atop{χ}$$ $$0\\atop{1}$$, where χ 1 0 (χ 1 ± ) denotes the lightest neutralino (chargino). Exclusion limits are placed in terms of the top-squark and neutralino masses. Assuming a branching ratio of 100% to t$$\\sim\\atop{χ}$$ $$0\\atop{1}$$, top-squark masses in the range 450–1000 GeV are excluded for $$\\sim\\atop{χ}$$ $$0\\atop{1}$$ masses below 160 GeV. In the case where m$$\\sim\\atop{t}$$ 1-m t+m $$\\sim\\atop{χ}$$ $$0\\atop{1}$$ , top-squark masses in the range 235–590 GeV are excluded.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaboud, M.; Aad, G.; Abbott, B.
A search for pair production of a scalar partner of the top quark in events with four or more jets plus missing transverse momentum is presented. Here, an analysis of 36.1 fb -1 ofmore » $$ \\sqrt{s}=13 $$ TeV proton-proton collisions collected using the ATLAS detector at the LHC yields no significant excess over the expected Standard Model background. To interpret the results a simplified supersymmetric model is used where the top squark is assumed to decay via $$\\sim\\atop{t}$$ 1→t(*)$$\\sim\\atop{χ}$$ $$0\\atop{1}$$ and $$\\sim\\atop{t}$$ 1→b$$\\sim\\atop{χ}$$ $$±\\atop{1}$$→bW(*)$$\\sim\\atop{χ}$$ $$0\\atop{1}$$, where χ 1 0 (χ 1 ± ) denotes the lightest neutralino (chargino). Exclusion limits are placed in terms of the top-squark and neutralino masses. Assuming a branching ratio of 100% to t$$\\sim\\atop{χ}$$ $$0\\atop{1}$$, top-squark masses in the range 450–1000 GeV are excluded for $$\\sim\\atop{χ}$$ $$0\\atop{1}$$ masses below 160 GeV. In the case where m$$\\sim\\atop{t}$$ 1-m t+m $$\\sim\\atop{χ}$$ $$0\\atop{1}$$ , top-squark masses in the range 235–590 GeV are excluded.« less
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Asymmetric Ion-Pairing Catalysis
Brak, Katrien
2014-01-01
Charged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesis. This review describes developments in the burgeoning field of asymmetric ion-pairing catalysis with an emphasis on the insights that have been gleaned into the structural and mechanistic features that contribute to high asymmetric induction. PMID:23192886
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A clinical trial for evaluation of leech application in the management of Vicarcikā (Eczema)
Shankar, K.M. Pratap; Rao, S. Dattatreya; Umar, Shaik Nafeez; Gopalakrishnaiah, V.
2014-01-01
Background: Skin diseases are among the most common health problems worldwide and are associated with a considerable burden. Eczema is such a skin ailment which cause psychological, social and financial burden on the patient and their families. Management of eczema with antibiotics, antihistamines, steroids etc., are available but even after their use relapses, recurrences and other complications are very common. Aim: The aim of this study was to assess the efficacy of leech application in the management of vicarcikā (Eczema) with standard clinical parameters viz. Eczema Area and Severity Index (EASI) score, SCORing of Atopic Dermatitis (SCORAD) Index and Dermatology Life Quality Index (DLQI). Materials and Methods: An open labeled clinical trial study without control group was conducted with 27 patients having the classical symptoms of vicarcikā (Eczema), selected as per the inclusion and exclusion criteria from outpatient department and inpatient department sections of Shalya Department, S.V. Ayurvedic Hospital, Tirupati. Minimum four sittings of leech application were carried out with 7 days interval. Pre- and post-treatment evaluation of the patient was done with Eczema Area and Severity Index (EASI) score, SCORing of Atopic Dermatitis (SCORAD) Index and Dermatology Life Quality Index (DLQI). Statistical Analysis: Analysis of the data was done with Student's paired t-test. Results: The total EASI score showed considerable reduction up to 54.45% (P < 0.01) and the SCORAD Index significantly reduced by 55% (P < 0.01). The life quality of the patient calculated by DLQI improved significantly by 62.36% (P < 0.01). Conclusion: Leech application gives significant relief for the symptoms of eczema. The life quality of the patient also improved significantly after leech therapy. No adverse reactions were reported during the entire course of study. PMID:25593404
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Atopic children and use of prescribed medication: A comprehensive study in general practice
Nielen, Mark M. J.; Bohnen, Arthur M.; Korevaar, Joke C.; Bindels, Patrick J. E.
2017-01-01
Purpose A comprehensive and representative nationwide general practice database was explored to study associations between atopic disorders and prescribed medication in children. Method All children aged 0–18 years listed in the NIVEL Primary Care Database in 2014 were selected. Atopic children with atopic eczema, asthma and allergic rhinitis (AR) were matched with controls (not diagnosed with any of these disorders) within the same general practice on age and gender. Logistic regression analyses were performed to study the differences in prescribed medication between both groups by calculating odds ratios (OR); 93 different medication groups were studied. Results A total of 45,964 children with at least one atopic disorder were identified and matched with controls. Disorder-specific prescriptions seem to reflect evidence-based medicine guidelines for atopic eczema, asthma and AR. However, these disorder-specific prescriptions were also prescribed for children who were not registered as having that specific disorder. For eczema-related medication, about 3.7–8.4% of the children with non-eczematous atopic morbidity received these prescriptions, compared to 1.4–3.5% of the non-atopic children. The same pattern was observed for anti-asthmatics (having non-asthmatic atopic morbidity: 0.8–6.2% vs. controls: 0.3–2.1%) and AR-related medication (having non-AR atopic morbidity: 4.7–12.5% vs. controls: 2.8–3.1%). Also, non-atopic related medication, such as laxatives and antibiotics were more frequently prescribed for atopic children. Conclusions The present study shows that atopic children received more prescriptions, compared to non-atopic children. Non-atopic controls frequently received specific prescriptions for atopic disorders. This indicates that children with atopic disorders need better monitoring by their GP. PMID:28837578
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Ab initio calculations of ionic hydrocarbon compounds with heptacoordinate carbon.
Wang, George; Rahman, A K Fazlur; Wang, Bin
2018-04-25
Ionic hydrocarbon compounds that contain hypercarbon atoms, which bond to five or more atoms, are important intermediates in chemical synthesis and may also find applications in hydrogen storage. Extensive investigations have identified hydrocarbon compounds that contain a five- or six-coordinated hypercarbon atom, such as the pentagonal-pyramidal hexamethylbenzene, C 6 (CH 3 ) 6 2+ , in which a hexacoordinate carbon atom is involved. It remains challenging to search for further higher-coordinated carbon in ionic hydrocarbon compounds, such as seven- and eight-coordinated carbon. Here, we report ab initio density functional calculations that show a stable 3D hexagonal-pyramidal configuration of tropylium trication, (C 7 H 7 ) 3+ , in which a heptacoordinate carbon atom is involved. We show that this tropylium trication is stable against deprotonation, dissociation, and structural deformation. In contrast, the pyramidal configurations of ionic C 8 H 8 compounds, which would contain an octacoordinate carbon atom, are unstable. These results provide insights for developing new molecular structures containing hypercarbon atoms, which may have potential applications in chemical synthesis and in hydrogen storage. Graphical abstract Possible structural transformations of stable configurations of (C 7 H 7 ) 3+ , which may result in the formation of the pyramidal structure that involves a heptacoordinate hypercarbon atom.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Anzelc, Meghan
2008-06-01
Bmore » $$0\\atop{s}$$ mixing studies provide a precision test of Charge-Parity violation in the Standard Model. A measurement of Δm s constrains elements of the CKM quark rotation matrix [1], providing a probe of Standard Model Charge-Parity violation. This thesis describes a study of $$0\\atop{s}$$ mixing in the semileptonic decay $$0\\atop{s}$$ → D s - μ +vX, where D s - → Φπ -, using data collected at the D-Zero detector at Fermi National Accelerator in atavia, Illinois. Approximately 2.8 fb -1 of data collected between April 2002 and August 2007 was used, covering the entirety of the Tevatron's RunIIa (April 2002 to March 2006) and part of RunIIb (March 2006-August 2007). Taggers using both opposite-side and same-side information were used to obtain the flavor information of the s 0 meson at production. The charge of the muon in the decay $$0\\atop{s}$$ → D s -μ +vX was used to determine the flavor of the $$0\\atop{s}$$ at decay. The $$d\\atop{0}$$ mixing frequency, Δm d, was measured to verify the analysis procedure. A log-likelihood calculation was performed, and a measurement of Δm s was obtained. The final result was Δm s = 18.86 ± 0.80(stat.) ± 0.37(sys.) with a significance of 2.6σ.« less
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Measurement of the dijet transverse thrust distribution in proton - anti-proton collisions
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sorin, Maria Veronica
2003-01-01
This dissertation presents the first measurement in a hadron collider of an event shape variable, the Dijet Transverse Thrust Tmore » $$t\\atop{2}$$ which is sensitive to the spatial jet distribution on the plane perpendicular to the colliding p$$\\bar{p}$$ beams. $$t\\atop{2}$$ is calculated with the two most energetic jets reconstructed with the k$$\\perp$$ algorithm, and it ranges from T$$t\\atop{2}$$ =1, for a pencil-like configuration, to T$$t\\atop{2}$$ =√2/2, for two equal energy jets at 90°. The measurement is based on 87.3 pb -1 of data collected with the D0 detector at the Fermilab Tevatron p$$\\bar{p}$$ Collider. The cross section is reported as a function of 1-T$$t\\atop{2}$$ and log (1-T$$t\\atop{2}$$), with enhances the high statistics T$$t\\atop{2}$$→1 region, and presented for four separate event energy ranges. The measurement is in good agreement with a fixed-order O(α$$3\\atop{s}$$) perturbative QCD prediction, except at high T$$t\\atop{2}$$, where resummation corrections are expected to be important, and below T$$t\\atop{2}$$≃√3/2, where the leading order diagrams contributing to T$$t\\atop{2}$$ are O(α$$4\\atop{s}$$). The data also show a very good level of agreement with a recent Next-to-Leading pQCD three jet generator which covers the full T$$t\\atop{2}$$ range, except for the T$$t\\atop{2}$$=1 point.« less
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Phenotypes of asthma revisited upon the presence of atopy.
Nieves, Ana; Magnan, Antoine; Boniface, Stéphanie; Proudhon, Hervé; Lanteaume, André; Romanet, Stéphanie; Vervloet, Daniel; Godard, Philippe
2005-03-01
Immunological studies claimed that atopic and non-atopic asthma share more similarities than differences. However, these two phenotypes of asthma are considered to be distinguishable upon distinct clinical patterns, which were not systematically assessed before in a large population. We studied characteristics discriminating atopic from non-atopic asthma among 751 asthmatic patients and 80 factors were analysed in univariate and multivariate analysis. Age, age of onset of asthma, female/male ratio were higher in non-atopic (n=200) than in atopic (n=551) asthmatics. Familial asthma, seasonal symptoms, rhinitis, conjunctivitis, allergen-triggered symptoms, improvement in altitude, exercise-induced asthma were associated with atopy. Non-atopic asthmatics displayed lower FEV(1) and FVC. Smoking was more frequent and asthma was more severe in these patients. Younger age, early onset, male sex, rhinitis and smoking were independent factors discriminating atopic from non-atopic asthma. This study establishes in a large population of asthmatics that although similarities exist between atopic and non-atopic asthma, two clinical phenotypes can still distinguish both kinds of asthma.
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Flexural eczema versus atopic dermatitis.
Jacob, Sharon E; Goldenberg, Alina; Nedorost, Susan; Thyssen, Jacob P; Fonacier, Luz; Spiewak, Radoslaw
2015-01-01
Flexural eczema and atopic dermatitis are frequently synonymized. As respiratory atopy is rarely tested for and found in these patients, systematically equating a flexural distribution of dermatitis with atopic dermatitis may too frequently result in misclassified diagnoses and potentially missed opportunity for intervention toward improving patients' symptoms and quality of life. We present a critical review of the available evidence for the atopic dermatitis diagnosis and discuss the similarities between atopic dermatitis and allergic contact dermatitis. Because neither flexural predilection nor atopy is specific for atopic dermatitis, we conclude that the term atopic dermatitis is a misnomer and propose an etymologic reclassification of atopic dermatitis to "atopy-related" dermatitis. Allergic contact dermatitis can induce an atopic dermatitis-like phenotype, and thus, flexural dermatitis cannot be assumed as atopic without further testing. Patch testing should at least be considered in cases of chronic or recurrent eczema regardless of the working diagnosis.
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Atopic dermatitis phenotypes and the need for personalized medicine
Cabanillas, Beatriz; Brehler, Ann-Christin; Novak, Natalija
2017-01-01
Purpose of review To describe recent developments in therapies which target the molecular mechanisms in atopic dermatitis. Recent findings Current advances in the understanding of the molecular basis of atopic dermatitis are leading to the stratification of different atopic dermatitis phenotypes. New therapies offer the option to target-specific molecules involved in the pathophysiology of atopic dermatitis. Current new therapies under investigation aim to modulate specific inflammatory pathways associated with distinctive atopic dermatitis phenotypes, which would potentially translate into the development of personalized, targeted-specific treatments of atopic dermatitis. Summary Despite the unmet need for well tolerated, effective, and personalized treatment of atopic dermatitis, the current standard treatments of atopic dermatitis do not focus on the individual pathogenesis of the disease. The development of targeted, phenotype-specific therapies has the potential to open a new promising era of individualized treatment of atopic dermatitis. PMID:28582322
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Greaves, Tamar L; Broomhall, Hayden; Weerawardena, Asoka; Osborne, Dale A; Canonge, Bastien A; Drummond, Calum J
2017-12-14
The phase behaviour of n-alkylammonium (C6 to C16) nitrates and formates has been characterised using synchrotron small angle and wide angle X-ray scattering (SAXS/WAXS), differential scanning calorimetry (DSC), cross polarised optical microscopy (CPOM) and Fourier transform infrared spectroscopy (FTIR). The protic salts may exist as crystalline, liquid crystalline or ionic liquid materials depending on the alkyl chain length and temperature. n-Alkylammonium nitrates with n ≥ 6 form thermotropic liquid crystalline (LC) lamellar phases, whereas n ≥ 8 was required for the formate series to form this LC phase. The protic ionic liquid phase showed an intermediate length scale nanostructure resulting from the segregation of the polar and nonpolar components of the ionic liquid. This segregation was enhanced for longer n-alkyl chains, with a corresponding increase in the correlation length scale. The crystalline and liquid crystalline phases were both lamellar. Phase transition temperatures, lamellar d-spacings, and liquid correlation lengths for the n-alkylammonium nitrates and formates were compared with those for n-alkylammonium chlorides and n-alkylamines. Plateau regions in the liquid crystalline to liquid phase transition temperatures as a function of n for the n-alkylammonium nitrates and formates are consistent with hydrogen-bonding and cation-anion interactions between the ionic species dominating alkyl chain-chain van der Waals interactions, with the exception of the mid chained hexyl- and heptylammonium formates. The d-spacings of the lamellar phases for both the n-alkylammonium nitrates and formates were consistent with an increase in chain-chain layer interdigitation within the bilayer-based lamellae with increasing alkyl chain length, and they were comparable to the n-alkylammonium chlorides.
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Development of solvent-free ambient mass spectrometry for green chemistry applications.
Liu, Pengyuan; Forni, Amanda; Chen, Hao
2014-04-15
Green chemistry minimizes chemical process hazards in many ways, including eliminating traditional solvents or using alternative recyclable solvents such as ionic liquids. This concept is now adopted in this study for monitoring solvent-free reactions and analysis of ionic liquids, solids, and catalysts by mass spectrometry (MS), without using any solvent. In our approach, probe electrospray ionization (PESI), an ambient ionization method, was employed for this purpose. Neat viscous room-temperature ionic liquids (RTILs) in trace amounts (e.g., 25 nL) could be directly analyzed without sample carryover effect, thereby enabling high-throughput analysis. With the probe being heated, it can also ionize ionic solid compounds such as organometallic complexes as well as a variety of neat neutral solid chemicals (e.g., amines). More importantly, moisture-sensitive samples (e.g., [bmim][AlCl4]) can be successfully ionized. Furthermore, detection of organometallic catalysts (including air-sensitive [Rh-MeDuPHOS][OTf]) in ionic liquids, a traditionally challenging task due to strong ion suppression effect from ionic liquids, can be enabled using PESI. In addition, PESI can be an ideal approach for monitoring solvent-free reactions. Using PESI-MS, we successfully examined the alkylation of amines by alcohols, the conversion of pyrylium into pyridinium, and the condensation of aldehydes with indoles as well as air- and moisture-sensitive reactions such as the oxidation of ferrocene and the condensation of pyrazoles with borohydride. Interestingly, besides the expected reaction products, the reaction intermediates such as the monopyrazolylborate ion were also observed, providing insightful information for reaction mechanisms. We believe that the presented solvent-free PESI-MS method would impact the green chemistry field.
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Wrinkling of solidifying polymeric coatings
NASA Astrophysics Data System (ADS)
Basu, Soumendra Kumar
2005-07-01
In coatings, wrinkles are viewed as defects or as desired features for low gloss, and texture. In either case, discovering the origin of wrinkles and the conditions that lead to their formation is important. This research examines what wrinkling requires and proposes a mechanism to explain the observations. All curing wrinkling coatings contain multi-functional reactants. Upon curing, all develop a depth-wise gradient in solidification that result in a cross-linked elastic skin atop a viscous bottom layer. It is hypothesized that compressive stress develops in the skin when liquid below diffuses up into the skin. High enough compressive stress buckles the skin to produce wrinkles. The hypothesis is substantiated by experimental and theoretical evidences. Effects of various application and compositional parameters on wrinkle size in a liquid-applied acrylic coating and a powder-applied epoxy coating were examined. All three components, namely resin, cross-linker and catalyst blocked with at least equimolar volatile blocker, proved to be required for wrinkling. The wrinkling phenomenon was modeled with a theory that accounts for gradient generation, cross-linking reaction and skinning; predictions compared well with observations. Two-layer non-curing coatings that have a stiff elastic layer atop a complaint elastic bottom layer wrinkled when the top layer is compressed. The top layer was compressed by either moisture absorption or differential thermal expansion. Experimental observations compared well with predictions from a theory based on force balance in multilayer systems subjected to differential contraction or expansion. A model based on the Flory-Rehner free energy of a constrained cross-linked gel was constructed that predicts the compressive stress generated in a coating when it absorbs solvent. Linear stability analysis predicts that when a compressed elastic layer is attached atop a viscous layer, it is always unstable to buckles whose wavelength exceeds a critical value; more cross-linking and poor solvent produce higher wavelength, lower amplitude wrinkles. When a compressed elastic layer is attached atop an elastic layer and subjected to more than a critical compressive stress, it is unstable to intermediate wavelengths of buckling; better solvent, higher ratio of bottom-to-top layer thickness, and lower bottom layer modulus produce higher wavelength, higher amplitude wrinkles.
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Marques dos Santos, Letícia; Neves dos Santos, Darci; Rodrigues, Laura Cunha; Barreto, Maurício Lima
2012-11-01
Atopic and non-atopic asthma have distinct risk factors and immunological mechanisms, and few studies differentiate between the impacts of psychosocial factors on the prevalence of these disease phenotypes. The authors aimed to identify whether the effect of maternal mental health on prevalence of asthma symptoms differs between atopic and non-atopic children, taking into account family social support. This is a cross-sectional study of 1013 children participating in the Social Change Allergy and Asthma in Latin America project. Psychosocial data were collected through a household survey utilising Self-Reporting Questionnaire and Medical Outcome Study Social Support Scale. Socioeconomic and wheezing information was obtained through the questionnaire of the International Study of Allergy and Asthma in Childhood, and level of allergen-specific IgE was measured to identify atopy. Polytomous logistic regression was used to estimate the association between maternal mental health, social support and atopic and non-atopic wheezing. Effect modification was evaluated through stratified polytomous regression according to social support level. Maternal mental disorder had the same impact on atopic and non-atopic wheezing, even after adjusting for confounding variables. Affective, material and informational supports had protective effects on non-atopic asthma, and there is some evidence that social supports may act as a buffer for the impact of maternal mental disorder on non-atopic wheezing. Poor maternal mental health is positively associated with wheezing, independent of whether asthma is atopic or non-atopic, but perception of high levels of social support appears to buffer this relationship in non-atopic wheezers only.
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NASA Astrophysics Data System (ADS)
Daly, Ryan P.; Araque, Juan C.; Margulis, Claudio J.
2017-08-01
In a recent set of articles [J. C. Araque et al., J. Phys. Chem. B 119(23), 7015-7029 (2015) and J. C. Araque et al., J. Chem. Phys. 144, 204504 (2016)], we proposed the idea that for small neutral and charged solutes dissolved in ionic liquids, deviation from simple hydrodynamic predictions in translational and rotational dynamics can be explained in terms of diffusion through nano-environments that are stiff (high electrostriction, charge density, and number density) and others that are soft (charge depleted). The current article takes a purely solvent-centric approach in trying to provide molecular detail and intuitive visual understanding of time-dependent local mobility focusing on the most common case of an ionic liquid with well defined polar and apolar nano-domains. We find that at intermediate time scales, apolar regions are fluid, whereas the charge network is much less mobile. Because apolar domains and cationic heads must diffuse as single species, at long time the difference in mobility also necessarily dissipates.
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Structural analysis of zwitterionic liquids vs. homologous ionic liquids
NASA Astrophysics Data System (ADS)
Wu, Boning; Kuroda, Kosuke; Takahashi, Kenji; Castner, Edward W.
2018-05-01
Zwitterionic liquids (Zw-ILs) have been developed that are homologous to monovalent ionic liquids (ILs) and show great promise for controlled dissolution of cellulosic biomass. Using both high energy X-ray scattering and atomistic molecular simulations, this article compares the bulk liquid structural properties for novel Zw-ILs with their homologous ILs. It is shown that the significant localization of the charges on Zw-ILs leads to charge ordering similar to that observed for conventional ionic liquids with monovalent anions and cations. A low-intensity first sharp diffraction peak in the liquid structure factor S(q) is observed for both the Zw-IL and the IL. This is unexpected since both the Zw-IL and IL have a 2-(2-methoxyethoxy)ethyl (diether) functional group on the cationic imidazolium ring and ether functional groups are known to suppress this peak. Detailed analyses show that this intermediate range order in the liquid structure arises for slightly different reasons in the Zw-IL vs. the IL. For the Zw-IL, the ether tails in the liquid are shown to aggregate into nanoscale domains.
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Base-Metal Electrode-Multilayer Ceramic Capacitors: Past, Present and Future Perspectives
NASA Astrophysics Data System (ADS)
Kishi, Hiroshi; Mizuno, Youichi; Chazono, Hirokazu
2003-01-01
Multilayer ceramic capacitor (MLCC) production and sales figures are the highest among fine-ceramic products developed in the past 30 years. The total worldwide production and sales reached 550 billion pieces and 6 billion dollars, respectively in 2000. In the course of progress, the development of base-metal electrode (BME) technology played an important role in expanding the application area. In this review, the recent progress in MLCCs with BME nickel (Ni) electrodes is reviewed from the viewpoint of nonreducible dielectric materials. Using intermediate-ionic-size rare-earth ion (Dy2O3, Ho2O3, Er2O3, Y2O3) doped BaTiO3 (ABO3)-based dielectrics, highly reliable Ni-MLCCs with a very thin layer below 2 μm in thickness have been developed. The effect of site occupancy of rare-earth ions in BaTiO3 on the electrical properties and microstructure of nonreducible dielectrics is studied systematically. It appears that intermediate-ionic-size rare-earth ions occupy both A- and B-sites in the BaTiO3 lattice and effectively control the donor/acceptor dopant ratio and microstructural evolution. The relationship between the electrical properties and the microstructure of Ni-MLCCs is also presented.
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NASA Astrophysics Data System (ADS)
Nasto, Alice; Hosoi, Anette
2017-11-01
Using a combination of experiments and theory, we investigate the effect of a millimeter-scale hairy texture on impact of liquid drops. By varying the speed of the drop at impact and the spacing of the hairs, we observe a variety of behaviors. For dense hairs and low impact velocity, the liquid drop sits on top of the hair, similar to a Cassie-Baxter state. For higher impact velocity, and intermediate to high density of hairs, the drops penetrate through the surface, but the hairs resist their spreading. For low hair density and high impact velocity, the drops impact and splash.
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Rożalski, Michał; Rudnicka, Lidia; Samochocki, Zbigniew
2016-06-01
Atopic dermatitis is a common term used in the medical literature, but according to The Nomenclature Review Committee Of The World Allergy Organization the name which should be used is eczema. Eczema is divided into two subtypes: atopic and non-atopic. These subtypes differ in the level of total immunoglobulin E (IgE) in serum, response to allergens in skin prick tests, and detection of specific IgE antibodies. Non-atopic eczema is characterized by a low level of total IgE, negative skin prick tests, and undetectable specific IgE antibodies. It is estimated that 10-45% cases of eczema are non-atopic ones. In recent studies, other features differentiating these two subtypes have been identified, such as female predominance in non-atopic eczema. A more severe course, damage of the epidermal barrier, predominance of Th2 (T helper cells 2) response, and a lower positive reaction to metal patch tests are the characteristics of the atopic subtype. In our opinion, new diagnostic criteria taking into account the non-atopic subtype of eczema need to be established.
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B s 0 lifetime measurement in the C P -odd decay channel B s 0 → J / ψ f 0 ( 980 )
DOE Office of Scientific and Technical Information (OSTI.GOV)
Abazov, V. M.; Abbott, B.; Acharya, B. S.
2016-07-01
Here, the lifetime of the Bmore » $$0\\atop{S}$$ meson is measured in the decay channel B$$0\\atop{S}$$→J/ψπ +π - with 880 ≤ M π+π- ≤ 1080 MeV/c 2, which is mainly a CP-odd state and dominated by the f 0(980) resonance. In 10.4 fb -1 of data collected with the D0 detector in Run II of the Tevatron, the lifetime of the B$$0\\atop{S}$$ meson is measured to be τ(B$$0\\atop{S}$$) = 1.70 ± 0.14(stat) ± 0.05(syst) ps. Neglecting CP violation in B$$0\\atop{S}/$$\\bar{B}$ 0 s mixing, the measurement can be translated into the width of the heavy mass eigenstate of the B$$0\\atop{S}$$, Γ H = 0.59 ± 0.05(stat) ± 0.02(syst) ps -1.« less
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NASA Astrophysics Data System (ADS)
Buyukkilic, Salih
Solid oxide fuel cells (SOFCs) have potential to convert chemical energy directly to electrical energy with high efficiency, with only water vapor as a by-product. However, the requirement of extremely high operating temperatures (~1000 °C) limits the use of SOFCs to only in large scale stationary applications. In order to make SOFCs a viable energy solution, enormous effort has been focused on lowering the operating temperatures below 700 °C. A low temperature operation would reduce manufacturing costs by slowing component degradation, lessening thermal mismatch problems, and sharply reducing costs of operation. In order to optimize SOFC applications, it is critical to understand the thermodynamic stabilities of electrolytes since they directly influence device stability, sustainability and performance. Rare-earth doped ceria electrolytes have emerged as promising materials for SOFC applications due to their high ionic conductivity at the intermediate temperatures (500--700 °C). However there is a fundamental lack of understanding regarding their structure, thermodynamic stability and properties. Therefore, the enthalpies of formation from constituent oxides and ionic conductivities were determined to investigate a relationship between the stability, composition, structural defects and ionic conductivity in rare earth doped ceria systems. For singly doped ceria electrolytes, we investigated the solid solution phase of bulk Ce1-xLnxO2-0.5x where Ln = Sm and Nd (0 ≤ x ≤ 0.30) and analyzed their enthalpies of formation, mixing and association, and bulk ionic conductivities while considering cation size mismatch and defect associations. It was shown that for ambient temperatures in the dilute dopant region, the positive heat of formation reaches a maximum as the system becomes increasingly less stable due to size mismatch. In concentrated region, stabilization to a certain solubility limit was observed probably due to the defect association of trivalent cations with charge-balancing oxygen vacancies. At higher temperatures near 700 °C, maximum enthalpy of formation shifts toward higher dopant concentrations, as a result of defect disordering. This concentration coincides with that of maximum ionic conductivity, extending the correlation seen previously near room temperature. It is also possible to co-dope these systems with Sm and Nd to further enhance ionic conductivity. For doubly doped ceria electrolytes, the solid solution phase of Ce1-xSm0.5xNd0.5xO2-0.5x (0 ≤ x ≤ 0.30) was investigated. It has been shown that for doubly doped ceria, the maximum enthalpy of formation occurs towards higher dopant concentration than that of singly doped counterparts, with less exothermic association enthalpies. These studies provide insight into the structure-composition-property-stability relations and aid in the rational design of the future SOFCs electrolytes.
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Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?
Figueiredo, Camila Alexandrina; Rodrigues, Laura Cunha; Alcantara-Neves, Neuza Maria; Cooper, Philip J; Amorim, Leila Denise; Silva, Nivea Bispo; Cruz, Alvaro A; Barreto, Mauricio Lima
2012-12-19
In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.
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Observation of Bs-Bsbar Oscillations Using Partially Reconstructed Hadronic Bs Decays
DOE Office of Scientific and Technical Information (OSTI.GOV)
Miles, Jeffrey Robert
2008-02-01
This thesis describes the contribution of partially reconstructed hadronic decays in the world's first observation of Bmore » $$0\\atop{s}$$-$$\\bar{B}$$$0\\atop{s}$$ oscillations. The analysis is a core member of a suite of closely related studies whose combined time-dependent measurement of the B$$0\\atop{s}$$-$$\\bar{B}$$$0\\atop{s}$$ oscillation frequency Δm s is of historic significance. Using a data sample of 1 fb -1 of p$$\\bar{p}$$ collisions at √s = 1.96 TeV collected with the CDF-II detector at the Fermilab Tevatron, they find signals of 3150 partially reconstructed hadronic B s decays from the combined decay channels B$$0\\atop{s}$$ → D*$$-\\atop{s}$$ π + and B$$0\\atop{s}$$ → D$$-\\atop{s}$$ ρ + with D$$-\\atop{s}$$ → Φπ -. These events are analyzed in parallel with 2000 fully reconstructed B$$0\\atop{s}$$ → D$$-\\atop{s}$$ π + (D$$-\\atop{s}$$ → Φπ -) decays. The treatment of the data is developed in stages of progressive complexity, using high-statistics samples of hadronic B 0and B + decays to study the attributes of partially reconstructed events. The analysis characterizes the data in mass and proper decay time, noting the potential of the partially reconstructed decays for precise measurement of B branching fractions and lifetimes, but consistently focusing on the effectiveness of the model for the oscillation measurement. They efficiently incorporate the measured quantities of each decay into a maximum likelihood fitting framework, from which they extract amplitude scans and a direct measurement of the oscillation frequency. The features of the amplitude scans are consistent with expected behavior, supporting the correctness of the calibrations for proper time uncertainty and flavor tagging dilution. The likelihood allows for the smooth combination of this analysis with results from other data samples, including 3500 fully reconstructed hadronic B s events and 61,500 partially reconstructed semileptonic B s events. The individual analyses show compelling evidence for B$$0\\atop{s}$$-$$\\bar{B}$$$0\\atop{s}$$ oscillations, and the combination yields a clear signal. The probability that random fluctuations could produce a comparable signature is 8 x 10 -8, which exceeds the 5 standard deviations threshold of significance for observation. The discovery threshold would not be achieved without inclusion of the partially reconstructed hadronic decays. They measure Δm s = 17.77 ± 0.10(stat) ± 0.07(syst) ps -1 and extract |V td/V ts| = 0.2060 ± 0.0007(exp)$$+0.0081\\atop{-0.0060}$$(theory), consistent with the Standard Model expectation.« less
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Photochemical and radiation-chemical aspects of matrix acidity effects on some organic systems
NASA Astrophysics Data System (ADS)
Ambroz, H. B.; Przybytniak, G. K.; Wronska, T.; Kemp, T. J.
The role of matrix effects in radiolysis and photolysis is illustrated using two systems: organosulphur compounds and benzenediazonium salts. Their intermediates as detected by low temperature ESR and optical spectroscopy or FAB-MS give evidence that the main reaction pathways depend strongly on these effects. Changes in matrix acidity can control the formation of neutral radical, ion-radical or ionic species which are crucial to the character of the final products of irradiation of organosulphur compounds, which are of great importance in medicine, biology, ecology and industry. Microenvironmental influences determine whether the triplet aryl cation or radical species are detected as the principal or sole intermediates in the decomposition of diazonium salts, a process leading to different stable products with industrial application.
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Exploring the origins of asthma: Lessons from twin studies
2014-01-01
This thesis explores the contribution of twin studies, particularly those studies originating from the Danish Twin Registry, to the understanding of the aetiology of asthma. First, it is explored how twin studies have established the contribution of genetic and environmental factors to the variation in the susceptibility to asthma, and to the variation in several aspects of the clinical expression of the disease such as its age at onset, its symptomatology, its intermediate phenotypes, and its relationship with other atopic diseases. Next, it is explored how twin studies have corroborated theories explaining asthma's recent increase in prevalence, and last, how these fit with the explanations of the epidemiological trends in other common chronic diseases of modernity. PMID:26557247
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
2011-09-01
Guide to the student-designed houses, ten contests, exhibits, and workshops of the U.S. Department of Energy 2011 Solar Decathlon, held in Washington, D.C., from September 23 through October 2, 2011. Teams of college students designed and built the solar-powered houses on display here. They represent 13 U.S. states, five countries, and four continents. Now the teams are rising to the challenge by competing in 10 contests over nine days, with the championship trophy on the line. This is their time to shine. The 2011 teams may share a common goal - to design and build the best energy-efficient house poweredmore » by the sun - but their strategies are different. One house is made of precast concrete, while another 'dances' in response to its environment. Another house is meant to sit atop a building, proving the sky's the limit for energy innovation. Whatever your idea of sustainable living may be, you are bound to find it at the Solar Decathlon.« less
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1996-01-01
Laptop computer sits atop the Experiment Control Computer for a NASA Bioreactor. The flight crew can change operating conditions in the Bioreactor by using the graphical interface on the laptop. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
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Microminiature optical waveguide structure and method for fabrication
Strand, O.T.; Deri, R.J.; Pocha, M.D.
1998-12-08
A method for manufacturing low-cost, nearly circular cross section waveguides comprises starting with a substrate material that a molten waveguide material can not wet or coat. A thin layer is deposited of an opposite material that the molten waveguide material will wet and is patterned to describe the desired surface-contact path pedestals for a waveguide. A waveguide material, e.g., polymer or doped silica, is deposited. A resist material is deposited and unwanted excess is removed to form pattern masks. The waveguide material is etched away to form waveguide precursors and the masks are removed. Heat is applied to reflow the waveguide precursors into near-circular cross-section waveguides that sit atop the pedestals. The waveguide material naturally forms nearly circular cross sections due to the surface tension effects. After cooling, the waveguides will maintain the round shape. If the width and length are the same, then spherical ball lenses are formed. Alternatively, the pedestals can be patterned to taper along their lengths on the surface of the substrate. This will cause the waveguides to assume a conical taper after reflowing by heat. 32 figs.
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Microminiature optical waveguide structure and method for fabrication
Strand, Oliver T.; Deri, Robert J.; Pocha, Michael D.
1998-01-01
A method for manufacturing low-cost, nearly circular cross section waveguides comprises starting with a substrate material that a molten waveguide material can not wet or coat. A thin layer is deposited of an opposite material that the molten waveguide material will wet and is patterned to describe the desired surface-contact path pedestals for a waveguide. A waveguide material, e.g., polymer or doped silica, is deposited. A resist material is deposited and unwanted excess is removed to form pattern masks. The waveguide material is etched away to form waveguide precursors and the masks are removed. Heat is applied to reflow the waveguide precursors into near-circular cross-section waveguides that sit atop the pedestals. The waveguide material naturally forms nearly circular cross sections due to the surface tension effects. After cooling, the waveguides will maintain the round shape. If the width and length are the same, then spherical ball lenses are formed. Alternatively, the pedestals can be patterned to taper along their lengths on the surface of the substrate. This will cause the waveguides to assume a conical taper after reflowing by heat.
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2006-08-02
KENNEDY SPACE CENTER, FLA. - In the bright light of day, Space Shuttle Atlantis nears the hard stand on Launch Pad 39B. First motion out of the Vehicle Assembly Building was 1:05 a.m. The shuttle sits on top of the mobile launcher platform, which in turn rests on the crawler-transporter. At right is the 290-foot high, 300,000- gallon water tank that aids in sound suppression during launch. The water releases just prior to the ignition of the shuttle engines and flows through 7-foot-diameter pipes for about 20 seconds, pouring into 16 nozzles atop the flame deflectors and from outlets in the main engines exhaust hole in the mobile launcher platform. The slow speed of the crawler results in a 6-hour trek to the pad approximately 4 miles away. Atlantis' launch window begins Aug. 27 for an 11-day mission to the International Space Station. The STS-115 crew of six astronauts will continue construction of the station and install their cargo, the Port 3/4 truss segment with its two large solar arrays. Photo credit: NASA/Troy Cryder
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NASA Technical Reports Server (NTRS)
1996-01-01
Laptop computer sits atop the Experiment Control Computer for a NASA Bioreactor. The flight crew can change operating conditions in the Bioreactor by using the graphical interface on the laptop. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
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Arima, Kazuhiko; Gupta, Shaloo; Gadkari, Abhijit; Hiragun, Takaaki; Kono, Takeshi; Katayama, Ichiro; Demiya, Sven; Eckert, Laurent
2018-04-01
Atopic dermatitis is a chronic inflammatory skin disease. The objective of this study was to characterize the burden of atopic dermatitis in Japanese adult patients relative to the general population. Japanese adults (≥18 years) with a self-reported diagnosis of atopic dermatitis and adult controls without atopic dermatitis/eczema/dermatitis were identified from the 2013 Japan National Health and Wellness Survey. Atopic dermatitis patients were propensity-score matched with non-atopic dermatitis controls (1:2 ratio) on demographic variables. Patient-reported outcome data on comorbidities, mood and sleep disorders, health-related quality of life, work productivity and activity impairment, and health-care resource utilization were analyzed in atopic dermatitis patients and matched controls. A total of 638 Japanese adult patients with atopic dermatitis were identified, of whom 290 (45.5%) rated their disease as "moderate/severe" and 348 (54.5%) as "mild". The analysis cohort comprised 634 atopic dermatitis patients and 1268 matched controls. Atopic dermatitis patients reported a significantly higher prevalence of arthritis, asthma, nasal allergies/hay fever, anxiety, depression and sleep disorders compared with controls (all P < 0.001). Atopic dermatitis patients also reported a significantly poorer health-related quality of life, higher overall work and activity impairment, and higher health-care resource utilization (all P < 0.001). Self-rated disease severity was not associated with disease burden, except for a significantly higher overall work and activity impairment. In conclusion, Japanese adult patients with atopic dermatitis reported a substantial disease burden relative to adults without atopic dermatitis, suggesting an unmet need for effective strategies targeting disease management. © 2018 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.
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Montuschi, Paolo; Mondino, Chiara; Koch, Pierluigi; Barnes, Peter J; Ciabattoni, Giovanni
2006-08-01
Leukotriene (LT) E(4) and 8-isoprostane concentrations are elevated in exhaled breath condensate in children with asthma. The effects of leukotriene receptor antagonists (LTRAs) on exhaled leukotriene and prostanoids in children with asthma are unknown. (1) To study the effect of montelukast, a LTRA, on exhaled LTE(4), 8-isoprostane, and prostaglandin E(2) in children with asthma and atopic children; (2) to measure exhaled nitric oxide. An open-label study with oral montelukast (5 mg once daily for 4 weeks) was undertaken in 17 atopic children with asthma and 16 atopic children without asthma. Pretreatment exhaled LTE(4) (P < .0001) and 8-isoprostane (P < .0001) values were higher in atopic children with asthma than in atopic children without asthma. In atopic children with asthma, montelukast reduced exhaled LTE(4) by 33% (P < .001), and this reduction was correlated with pretreatment LTE(4) values (r = -0.90; P = .0001). Posttreatment exhaled LTE(4) levels in children with asthma were higher than pretreatment LTE(4) values in atopic children without asthma (P < .004). Montelukast had no effect on exhaled LTE(4) in atopic children without asthma (P = .74), or on exhaled 8-isoprostane (atopic children with asthma, P = .94; atopic children without asthma, P = .55) and PGE(2) (atopic children with asthma, P = .56; atopic children without asthma, P = .93) in both groups. In atopic children with asthma, exhaled nitric oxide concentrations were reduced by 27% (P < .05) after montelukast. Leukotriene receptor antagonists decrease exhaled LTE(4) in atopic children with asthma. This reduction is dependent on baseline exhaled LTE(4) values. Measurement of exhaled LTE(4) might help identify children with asthma most likely to benefit from LTRAs.
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NASA Astrophysics Data System (ADS)
Majkić, M. D.; Nedeljković, N. N.; Dojčilović, R. J.
2017-09-01
We consider the slow highly charged ions impinging upon a metal surface covered with a thin dielectric film, and formation of the surface nanostructures (craters) from the standpoint of the required energy. For the moderate ionic velocities, the size of the surface features depends on the deposited kinetic energy of the projectile and the ionic neutralization energy. The neutralization energy is calculated by employing the recently developed quasi-resonant two-state vector model for the intermediate Rydberg state population and the micro-staircase model for the cascade neutralization. The electron interactions with the ionic core, polarized dielectric and charge induced on the metal surface are modelled by the appropriate asymptotic expressions and the method for calculation of the effective ionic charges in the dielectric is proposed. The results are presented for the interaction of \\text{X}{{\\text{e}}Z+} ions (velocity v=0.25 a.u.; 25) with the metal surface (Co) covered with a thin dielectric film, for model values of dielectric constant inside the interaction region. In the absence of dielectric film, the neutralization energy is lower than the potential (ionization) energy due to the incomplete neutralization. The presence of dielectric film additionally decreases the neutralization energy. We calculate the projectile neutralization energy in the perturbed dielectric (perturbation is caused by the ionic motion and the surface structure formation). We correlate the neutralization energy added to the deposited kinetic energy with the experimentally obtained energy necessary for the formation of the nano-crater of a given depth.
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Zwickl, Lena L M N; Joekel, Deborah E; Fischer, Nina M; Rostaher, Ana; Thamsborg, Kristian; Deplazes, Peter; Favrot, Claude
2018-06-01
Total IgE concentrations are higher in dogs than in humans. Persistent Toxocara canis larval infection is prevalent in dogs and is associated with substantial specific antibody reactions. A correlation, however, between total IgE and T. canis-specific antibody levels in dogs has not been evaluated. To determine the relationship between total IgE, T. canis-specific IgG and IgE, and allergen-specific IgE levels in atopic and non-atopic dogs, and to evaluate possible confounding factors. Sera of 30 atopic and 30 non-atopic client-owned dogs. Total IgE, T. canis-specific antibody and allergen-specific IgE levels were evaluated by ELISA. Total IgE, T. canis-specific antibody and allergen-specific IgE levels were significantly higher in non-atopic compared to atopic dogs. A positive correlation was demonstrated between T. canis-specific IgG and T. canis-specific IgE; T. canis-specific IgG and total IgE; T. canis-specific IgE and total IgE; and allergen-specific IgE and total IgE. No differences were detected on the basis of age, gender, vaccination status; deworming or season between atopic and non-atopic dogs. Previous immunomodulatory treatment and cause of atopy did not influence antibody levels of atopic dogs. Toxocara canis-specific IgE appears to be a major component of total IgE in dogs. Total and T. canis-specific IgE levels are higher in non-atopic compared to atopic dogs. It is speculated that T. canis infection may have a protective effect against the development of canine atopic dermatitis and/or that elevations in total serum IgE level are often not associated with atopic dermatitis. © 2018 ESVD and ACVD.
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NASA Astrophysics Data System (ADS)
Hwang, Jinkwang; Matsumoto, Kazuhiko; Orikasa, Yuki; Katayama, Misaki; Inada, Yasuhiro; Nohira, Toshiyuki; Hagiwara, Rika
2018-02-01
Maricite NaFePO4 (m-NaFePO4) was investigated as a positive electrode material for intermediate-temperature operation of sodium secondary batteries using ionic liquid electrolytes. Powdered m-NaFePO4 was prepared by a conventional solid-state method at 873 K and subsequently fabricated in two different conditions; one is ball-milled in acetone and the other is re-calcined at 873 K after the ball-milling. Electrochemical properties of the electrodes prepared with the as-synthesized m-NaFePO4, the ball-milled m-NaFePO4, and the re-calcined m-NaFePO4 were investigated in Na[FSA]-[C2C1im][FSA] (C2C1im+ = 1-ethyl-3-methylimidazolium, FSA- = bis(fluorosulfonyl)amide) ionic liquid electrolytes at 298 K and 363 K to assess the effects of temperature and particle size on their electrochemical properties. A reversible charge-discharge capacity of 107 mAh g-1 was achieved with a coulombic efficiency >98% from the 2nd cycle using the ball-milled m-NaFePO4 electrode at a C-rate of 0.1 C and 363 K. Electrochemical impedance spectroscopy using m-NaFePO4/m-NaFePO4 symmetric cells indicated that inactive m-NaFePO4 becomes an active material through ball-milling treatment and elevation of operating temperature. X-ray diffraction analysis of crystalline m-NaFePO4 confirmed the lattice contraction and expansion upon charging and discharging, respectively. These results indicate that the desodiation-sodiation process in m-NaFePO4 is reversible in the intermediate-temperature range.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Abelev, B.; Adamczyk, L.; Adkins, J. K.
Here we present measurements of the near side of triggered di-hadron correlations using neutral strange baryons (more » $$Λ,\\overline{Λ}$$) and mesons (K$$0\\atop{S}$$ ) at intermediate transverse momentum (3 < pT< 6 GeV/c) to look for possible flavor and baryon-meson dependence. This study is performed in d+Au, Cu+Cu, and Au+Au collisions at $$\\sqrt{s}$$$_{NN}$$ = 200 GeV measured by the STAR experiment at RHIC. The near-side di-hadron correlation contains two structures, a peak which is narrow in azimuth and pseudorapidity consistent with correlations from jet fragmentation, and a correlation in azimuth which is broad in pseudorapidity. The particle composition of the jet-like correlation is determined using identified associated particles. The dependence of the conditional yield of the jet-like correlation on the trigger particle momentum, associated particle momentum, and centrality for correlations with unidentified trigger particles are presented. The neutral strange particle composition in jet-like correlations with unidentified charged particle triggers is not well described by PYTHIA. However, the yield of unidentified particles in jet-like correlations with neutral strange particle triggers is described reasonably well by the same model.« less
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Abelev, B.; Adamczyk, L.; Adkins, J. K.; ...
2016-07-28
Here we present measurements of the near side of triggered di-hadron correlations using neutral strange baryons (more » $$Λ,\\overline{Λ}$$) and mesons (K$$0\\atop{S}$$ ) at intermediate transverse momentum (3 < pT< 6 GeV/c) to look for possible flavor and baryon-meson dependence. This study is performed in d+Au, Cu+Cu, and Au+Au collisions at $$\\sqrt{s}$$$_{NN}$$ = 200 GeV measured by the STAR experiment at RHIC. The near-side di-hadron correlation contains two structures, a peak which is narrow in azimuth and pseudorapidity consistent with correlations from jet fragmentation, and a correlation in azimuth which is broad in pseudorapidity. The particle composition of the jet-like correlation is determined using identified associated particles. The dependence of the conditional yield of the jet-like correlation on the trigger particle momentum, associated particle momentum, and centrality for correlations with unidentified trigger particles are presented. The neutral strange particle composition in jet-like correlations with unidentified charged particle triggers is not well described by PYTHIA. However, the yield of unidentified particles in jet-like correlations with neutral strange particle triggers is described reasonably well by the same model.« less
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Bazavov, A.; Ding, H. -T.; Hegde, P.; ...
2017-10-27
In this paper, we present results for the ratios of mean (M B), variance (σmore » $$2\\atop{B}$$), skewness (S B) and kurtosis (κ B) of net baryon-number fluctuations obtained in lattice QCD calculations with physical values of light and strange quark masses. Using next-to-leading order Taylor expansions in baryon chemical potential we find that qualitative features of these ratios closely resemble the corresponding experimentally measured cumulants ratios of net proton-number fluctuations for beam energies down to √sNN ≥ 19.6 GeV. We show that the difference in cumulant ratios for the mean net baryon-number, M B/σ$$2\\atop{B}$$ = χ$$B\\atop{1}$$ (T, µ B)/χ$$B\\atop{2}$$ (T, µ B) and the normalized skewness, S Bσ B = χ$$B\\atop{3}$$ (T, µB)/χ2 (T, µB ), nat-urally arises in QCD thermodynamics. Moreover, we establish a close relation between skewness and kurtosis ratios, S Bσ$$B\\atop{3}$$/M B = χ$$B\\atop{3}$$ (T, µ B)/χ$$B\\atop{1}$$ (T,µ B) and κ Bσ$$2\\atop{B}$$ = χ$$B\\atop{4}$$ (T,μ B)/χ$$B\\atop{2}$$ (T,μ B), valid at small values of the baryon chemical potential.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Bazavov, A.; Ding, H. -T.; Hegde, P.
In this paper, we present results for the ratios of mean (M B), variance (σmore » $$2\\atop{B}$$), skewness (S B) and kurtosis (κ B) of net baryon-number fluctuations obtained in lattice QCD calculations with physical values of light and strange quark masses. Using next-to-leading order Taylor expansions in baryon chemical potential we find that qualitative features of these ratios closely resemble the corresponding experimentally measured cumulants ratios of net proton-number fluctuations for beam energies down to √sNN ≥ 19.6 GeV. We show that the difference in cumulant ratios for the mean net baryon-number, M B/σ$$2\\atop{B}$$ = χ$$B\\atop{1}$$ (T, µ B)/χ$$B\\atop{2}$$ (T, µ B) and the normalized skewness, S Bσ B = χ$$B\\atop{3}$$ (T, µB)/χ2 (T, µB ), nat-urally arises in QCD thermodynamics. Moreover, we establish a close relation between skewness and kurtosis ratios, S Bσ$$B\\atop{3}$$/M B = χ$$B\\atop{3}$$ (T, µ B)/χ$$B\\atop{1}$$ (T,µ B) and κ Bσ$$2\\atop{B}$$ = χ$$B\\atop{4}$$ (T,μ B)/χ$$B\\atop{2}$$ (T,μ B), valid at small values of the baryon chemical potential.« less
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Elistratova, I V; Morozov, S G; Zakharova, I A; Tarasova, M V
2015-01-01
Aim of this work was to record the luminol-dependent spontaneous and induced chemiluminescence at the different stages of atopic dermatitis. Peripheral blood cells were obtained from adult patient with atopic dermatitis followed by the registration of luminol-dependent chemiluminescence on luminograph. Opsonized zymosan as well as yeasts Candida tropicalis have been used to induce the chemiluminescence. Spontaneous and induced chemiluminescence were slightly elevated at the mild atopic dermatitis but were decreased at the severe stage of disease. Statistically significant difference has been found between group with mild and severe atopic dermatitis, Skin contamination by yeasts Candida tropicalis causes the increased level of blood cells chemiluminescence at the first week of atopic relapse when the disease was mild. Severe stage of atopic dermatitis was coupled with statistically significant inhibition of both, spontaneous and induced chemiluminescence. Luminol-dependent chemiluminescence of peripheral blood cells from adult atopic dermatitis patients may be stimulated at the mild stage and suppressed at severe stage of atopic dermatitis.
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Wei, Han-Ting; Lan, Wen-Hsuan; Hsu, Ju-Wei; Huang, Kai-Lin; Su, Tung-Ping; Li, Cheng-Ta; Lin, Wei-Chen; Chen, Tzeng-Ji; Bai, Ya-Mei; Chen, Mu-Hong
2016-10-01
Previous studies have found an increased prevalence of atopic diseases among patients with major depression and bipolar disorder. But the temporal association between atopic diseases in adolescence and the subsequent risk of developing mood disorders has been rarely investigated. Using the Taiwan National Health Insurance Research Databases, 5075 adolescents with atopic diseases (atopic cohort) and 44,729 without (non-atopic cohort) aged between 10 and 17 in 2000 were enrolled into our study and followed to the end of 2010. Subjects who developed major depression or bipolar disorder during the follow-up were identified. The atopic cohort had an increased risk of developing major depression (HR: 2.45, 95% CI: 1.93~3.11) and bipolar disorder (HR: 2.51, 95% CI: 1.71~3.67) compared to the non-atopic cohort, with a dose-dependent relationship between having a greater number of atopic comorbidities and a greater likelihood of major depression (1 atopic disease: HR: 1.80, 95% CI: 1.29~2.50; 2 atopic comorbidities: HR: 2.42, 95% CI: 1.93~3.04;≥3 atopic comorbidities: HR: 3.79, 95% CI: 3.05~4.72) and bipolar disorder (HR: 1.40, 95% CI: 0.57~3.44; HR: 2.81, 95% CI: 1.68~4.68; HR: 3.02, 95% CI: 1.69~5.38). Having atopic diseases in adolescence increased the risk of developing major depression and bipolar disorder in later life. Further studies may be required to clarify the underlying mechanism between atopy and mood disorders, and to investigate whether prompt intervention may decrease the risk of subsequent mood disorders. Copyright © 2016 Elsevier B.V. All rights reserved.
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Laitinen, K; Sallinen, J; Linderborg, K; Isolauri, E
2006-02-01
The major theory implicating diet with allergic diseases is associated with altered food consumption and subsequent changes in fatty acid composition. To investigate fatty acid compositions among infants with atopic and non-atopic eczema and healthy infants and to evaluate the expediency of non-invasive cheek cell phospholipid fatty acid composition as a marker in patients with eczema. Diagnosis of eczema in infants was confirmed clinically and by positive (atopic eczema, n=6) or negative (non-atopic eczema, n=6) skin prick testing in comparison with controls (n=19). The fatty acid compositions of infant cheek cell and serum phospholipids and breast milk total lipids were analysed by gas chromatography. The distinction between atopic and non-atopic eczema was manifested in cheek cell phospholipids as linoleic acid (14.69 (13.67-15.53)% of total fatty acids; the median (interquartile range)), the sum of n-6 fatty acids (19.94 (19.06-20.53)%) and the sum of polyunsaturated fatty acids (22.70 (21.31-23.28)%) were higher in infants with atopic eczema compared with non-atopic eczema (12.69 (10.87-13.93); 17.72 (15.63-18.91) and 19.90 (17.64-21.06), respectively; P<0.05) and controls (12.50 (12.16-13.42); 18.19 (17.43-18.70) and 20.32 (19.32-21.03), respectively; P<0.05). Serum phospholipid gamma-linolenic acid was lower in both atopic and non-atopic eczema compared with controls (P<0.05) and additionally eicosapentaenoic acid was higher in atopic eczema compared with controls (P<0.05). These preliminary results suggest differences in fatty acid compositions between the two types of eczema, calling for further evaluation in a larger setting. The two types of eczema may be regulated by different immunological processes, and fatty acids may have a more profound role in the atopic type.
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Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center
2010-01-01
Background The causation of asthma is poorly understood. Risk factors for atopic and non-atopic asthma may be different. This study aimed to analyze the associations between markers of poverty, dirt and infections and wheezing in atopic and non-atopic children. Methods 1445 children were recruited from a population-based cohort in Salvador, Brazil. Wheezing was assessed using the ISAAC questionnaire and atopy defined as allergen-specific IgE ≥0.70 kU/L. Relevant social factors, environmental exposures and serological markers for childhood infections were investigated as risk factors using multivariate multinomial logistic regression. Results Common risk factors for wheezing in atopic and non-atopic children, respectively, were parental asthma and respiratory infection in early childhood. No other factor was associated with wheezing in atopic children. Factors associated with wheezing in non-atopics were low maternal educational level (OR 1.49, 95% CI 0.98-2.38), low frequency of room cleaning (OR 2.49, 95% CI 1.27-4.90), presence of rodents in the house (OR 1.48, 95% CI 1.06-2.09), and day care attendance (OR 1.52, 95% CI 1.01-2.29). Conclusions Non-atopic wheezing was associated with risk factors indicative of poverty, dirt and infections. Further research is required to more precisely define the mediating exposures and the mechanisms by which they may cause non-atopic wheeze. PMID:21122116
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Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center.
Barreto, Mauricio L; Cunha, Sergio S; Fiaccone, Rosemeire; Esquivel, Renata; Amorim, Leila D; Alvim, Sheila; Prado, Matildes; Cruz, Alvaro A; Cooper, Philip J; Santos, Darci N; Strina, Agostino; Alcantara-Neves, Neuza; Rodrigues, Laura C
2010-12-01
The causation of asthma is poorly understood. Risk factors for atopic and non-atopic asthma may be different. This study aimed to analyze the associations between markers of poverty, dirt and infections and wheezing in atopic and non-atopic children. 1445 children were recruited from a population-based cohort in Salvador, Brazil. Wheezing was assessed using the ISAAC questionnaire and atopy defined as allergen-specific IgE ≥ 0.70 kU/L. Relevant social factors, environmental exposures and serological markers for childhood infections were investigated as risk factors using multivariate multinomial logistic regression. Common risk factors for wheezing in atopic and non-atopic children, respectively, were parental asthma and respiratory infection in early childhood. No other factor was associated with wheezing in atopic children. Factors associated with wheezing in non-atopics were low maternal educational level (OR 1.49, 95% CI 0.98-2.38), low frequency of room cleaning (OR 2.49, 95% CI 1.27-4.90), presence of rodents in the house (OR 1.48, 95% CI 1.06-2.09), and day care attendance (OR 1.52, 95% CI 1.01-2.29). Non-atopic wheezing was associated with risk factors indicative of poverty, dirt and infections. Further research is required to more precisely define the mediating exposures and the mechanisms by which they may cause non-atopic wheeze.
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Bonfim, Camila Barreto; dos Santos, Darci Neves; Barreto, Maurício Lima
2015-12-01
This study aims to describe the types of intrafamilial violence perpetrated against children according to living conditions, family factors, and child characteristics, and to identify the association between types of intrafamilial violence and asthma symptoms in atopic and non-atopic children. A cross-sectional study was carried out with 1,370 caregivers as part of the Social Changes, Asthma and Allergy in Latin America (SCAALA) study, conducted in 2006 in Brazil. The study population was selected by random sampling. The main outcome measures were atopic and non-atopic asthma. We investigate the association between intrafamilial violence and asthma symptoms in atopic and non-atopic children. A backward multivariate logistic polytomous regression was performed to verify the main association. Nonviolent discipline (NVD) and maltreatment nonviolent discipline (MNVD) were positively associated with non-atopic asthma symptoms (NVD: odds ratio (OR)=1.95/95% confidence interval (CI)=1.17-3.25; MNVD: OR=1.95/95% CI=1.19-3.20). However, for the most severe intrafamilial violence, this association was not found after control of potential confounders. This study demonstrates the effect of types of intrafamilial violence on non-atopic asthma. Intrafamilial violence against children represents one more component in the determination of non-atopic asthma in Latin America. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Shamim, Nabila; McKenna, Gregory B
2010-12-09
The present paper reports the results of a systematic rheological study of the dynamic moduli of 1-butyl 3-methylimidazolium tetrafluoroborate ([Bmim][BF(4)]), 1-butyl 3-methylimidazolium hexafluorophosphate ([Bmim][PF(6)]), and 1-ethyl 3-methylimidazolium ethylsulfate ([Emim][EtSO(4)]) in the vicinity of their respective glass transition temperatures. The results show an anomalous aging in that the dynamic and the low shear rate viscosities decrease with time at temperatures near to, but above, the glass transition temperature, and this is described. The samples that are aged into equilibrium obey the time-temperature superposition principle, and the shift factors and the viscosities follow classic super-Arrhenius behaviors with intermediate fragility values as the glass transition is approached. Similar experiments using a high-purity [Bmim][BF(4)] show that using a higher purity of the ionic liquid, while changing absolute values of the properties, does not eliminate the anomalous aging response. The data are also analyzed in a fashion similar to that used for polymer melts, and we find that these ionic liquids do not follow, for example, the Cox-Merz relationship between the steady shear viscosity and the dynamic viscosity.
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Electronic structure and O vacancy formation/migration in La0.825(Mg/Ca/Ba)0.125CoO3
NASA Astrophysics Data System (ADS)
Omotayo Akande, Salawu; Gan, Li-Yong; Schwingenschlögl, Udo
2016-04-01
The effect of A-site hole doping (Mg2+, Ca2+ or Ba2+) on the electronic and magnetic properties as well as the O vacancy formation and migration in perovskite LaCoO3 is studied using first-principles calculations. All three dopants are found to facilitate O vacancy formation. Substitution of La3+ with Ba2+/Mg2+ yields the lowest O vacancy formation energy for low/intermediate spin Co, implying that not only the structure but also the spin state of Co is a key parameter. Only for low spin Co the ionic radius is correlated with the O migration barrier. Enhanced migration for intermediate spin Co is ascribed to the availability of additional space at the transition state.
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2017-12-18
Moderate-to-Severe Atopic Dermatitis; Dermatitis, Dermatitis Atopic; Eczema, Skin Diseases, Skin; Diseases Genetic, Genetic; Diseases Inborn, Skin; Disease, Eczematous Skin; Hypersensitivity, Immediate; Hypersensitivity, Immune System Diseases; Dermatitis, Atopic
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Search for the Exotic Meson X ( 5568 ) with the Collider Detector at Fermilab
DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaltonen, T.; Amerio, S.; Amidei, D.
Here, a search for the exotic meson X(5568) decaying into the Bmore » $$0\\atop{s}$$ π ± final state is performed using data corresponding to 9.6 fb -1 from $$p\\bar{p}$$ collisions at $$\\sqrt{s}$$ = 1960 GeV recorded by the Collider Detector at Fermilab. No evidence for this state is found and an upper limit of 6.7% at the 95% confidence level is set on the fraction of B$$0\\atop{s}$$ produced through the X(5568)→B$$0\\atop{s}$$ π ± process.« less
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Search for the Exotic Meson X ( 5568 ) with the Collider Detector at Fermilab
Aaltonen, T.; Amerio, S.; Amidei, D.; ...
2018-05-18
Here, a search for the exotic meson X(5568) decaying into the Bmore » $$0\\atop{s}$$ π ± final state is performed using data corresponding to 9.6 fb -1 from $$p\\bar{p}$$ collisions at $$\\sqrt{s}$$ = 1960 GeV recorded by the Collider Detector at Fermilab. No evidence for this state is found and an upper limit of 6.7% at the 95% confidence level is set on the fraction of B$$0\\atop{s}$$ produced through the X(5568)→B$$0\\atop{s}$$ π ± process.« less
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Aad, G.; Abbott, B.; Abdallah, J.; ...
2014-06-01
Here, a search is presented for direct top squark pair production using events with at least two leptons including a same-flavour opposite-sign pair with invariant mass consistent with the Z boson mass, jets tagged as originating from b-quarks and missing transverse momentum. The analysis is performed with proton–proton collision data at √s = 8 TeV collected with the ATLAS detector at the LHC in 2012 corresponding to an integrated luminosity of 20.3 fb -1. No excess beyond the Standard Model expectation is observed. Interpretations of the results are provided in models based on the direct pair production of the heavier top squark state (more » $$\\sim\\atop{t}_2$$) followed by the decay to the lighter top squark state ($$\\sim\\atop{t}_1$$) via $$\\sim\\atop{t}_2$$ → Z$$\\sim\\atop{t}_1$$, and for $$\\sim\\atop{t}_1$$ pair production in natural gauge-mediated supersymmetry breaking scenarios where the neutralino ($$\\sim\\atop{χ}$$$0\\atop{1}$$) is the next-to-lightest supersymmetric particle and decays producing a Z boson and a gravitino ($$\\sim\\atop{G}$$) via the $$\\sim\\atop{χ}$$$0\\atop{1}$$ → Z G process.« less
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Atopic asthmatic subjects but not atopic subjects without ...
BACKGROUND: Asthma is a known risk factor for acute ozone-associated respiratory disease. Ozone causes an immediate decrease in lung function and increased airway inflammation. The role of atopy and asthma in modulation of ozone-induced inflammation has not been determined. OBJECTIVE: We sought to determine whether atopic status modulates ozone response phenotypes in human subjects. METHODS: Fifty volunteers (25 healthy volunteers, 14 atopic nonasthmatic subjects, and 11 atopic asthmatic subjects not requiring maintenance therapy) underwent a 0.4-ppm ozone exposure protocol. Ozone response was determined based on changes in lung function and induced sputum composition, including airway inflammatory cell concentration, cell-surface markers, and cytokine and hyaluronic acid concentrations. RESULTS: All cohorts experienced similar decreases in lung function after ozone. Atopic and atopic asthmatic subjects had increased sputum neutrophil numbers and IL-8 levels after ozone exposure; values did not significantly change in healthy volunteers. After ozone exposure, atopic asthmatic subjects had significantly increased sputum IL-6 and IL-1beta levels and airway macrophage Toll-like receptor 4, Fc(epsilon)RI, and CD23 expression; values in healthy volunteers and atopic nonasthmatic subjects showed no significant change. Atopic asthmatic subjects had significantly decreased IL-10 levels at baseline compared with healthy volunteers; IL-10 levels did not significa
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Atopic dermatitis and concomitant disease patterns in children up to two years of age.
Böhme, Maria; Lannerö, Eva; Wickman, Magnus; Nordvall, S Lennart; Wahlgren, Carl-Fredrik
2002-01-01
There are few prospective studies of atopic dermatitis and co-existing diseases such as respiratory infections in children up to 2 years of age. Using annual questionnaires, we studied the cumulative incidence of atopic dermatitis and concomitant symptoms indicating other atopic diseases and respiratory infections in 0-2-year-old children in a prospective birth cohort of 4089 children. We found associations between atopic dermatitis and asthma (ratio of proportion 1.45, 95% CI 1.16-1.80), allergic rhinoconjunctivitis (RP 2.25, CI 1.77-2.85), adverse reactions to foods (RP 3.20, CI 2.83-3.62), urticaria (RP 2.04, CI 1.80-2.31), acute otitis media (RP 1.13, CI 1.05-1.21), more than one pneumonia during the first and/or second year of life (RP 2.17, CI 1.14-4.15), and use of antibiotics at least twice yearly (RP 1.29, CI 1.07-1.56). The association between atopic dermatitis and respiratory infections persisted after stratification for asthma. There was a higher proportion of atopic disease manifestations, but not respiratory infections, in children with onset of atopic dermatitis during the first year of life than during the second. The study shows that during the first 2 years of life there is a significant association not only between atopic dermatitis and other atopic disease manifestations, but also between atopic dermatitis and respiratory infections manifested in an increased rate of acute otitis media, pneumonia and use of antibiotics.
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Empirical moments of inertia of axially asymmetric nuclei
Allmond, J. M.; Wood, J. L.
2017-02-06
We extracted empirical moments of inertia, J1, J2, J3, of atomic nuclei with E(4more » $$+\\atop{1}$$)/E(2$$+\\atop{1}$$ ) > 2.7 from experimental 2$$+\\atop{g,y}$$, energies and electric quadrupole matrix elements, determined from multi- step Coulomb excitation data, and the results are compared to expectations based on rigid and irro- tational inertial flow. Only by having the signs of the E2 matrix elements, i.e., <2$$+\\atop{g}$$ ||M (E2)||2$$+\\atop{g}$$> and <0$$+\\atop{g}$$ ||M (E2)||2$$+\\atop{g}$$> < 2$$+\\atop{g}$$ ||M (E2)||2$$+\\atop{γ}$$> <2$$+\\atop{γ}$$ ||M (E2)||0$$+\\atop{g}$$> , can a unique solution to all three components of the inertia tensor of an asymmetric top be obtained. And while the absolute moments of inertia fall between the rigid and irrotational values as expected, the relative moments of inertia appear to be qualitatively consistent with the β 2 sin 2(γ ) dependence of the Bohr Hamiltonian which originates from a SO(5) in- variance. A better understanding of inertial flow is central to improving collective models, particularly hydrodynamic-based collective models. The results suggest that a better description of collective dynamics and inertial flow for atomic nuclei is needed. The inclusion of vorticity degrees of freedom may provide a path forward. This is our first report of empirical moments of inertia for all three axes and the results should challenge both collective and microscopic descriptions of inertial flow.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Allmond, J. M.; Wood, J. L.
We extracted empirical moments of inertia, J1, J2, J3, of atomic nuclei with E(4more » $$+\\atop{1}$$)/E(2$$+\\atop{1}$$ ) > 2.7 from experimental 2$$+\\atop{g,y}$$, energies and electric quadrupole matrix elements, determined from multi- step Coulomb excitation data, and the results are compared to expectations based on rigid and irro- tational inertial flow. Only by having the signs of the E2 matrix elements, i.e., <2$$+\\atop{g}$$ ||M (E2)||2$$+\\atop{g}$$> and <0$$+\\atop{g}$$ ||M (E2)||2$$+\\atop{g}$$> < 2$$+\\atop{g}$$ ||M (E2)||2$$+\\atop{γ}$$> <2$$+\\atop{γ}$$ ||M (E2)||0$$+\\atop{g}$$> , can a unique solution to all three components of the inertia tensor of an asymmetric top be obtained. And while the absolute moments of inertia fall between the rigid and irrotational values as expected, the relative moments of inertia appear to be qualitatively consistent with the β 2 sin 2(γ ) dependence of the Bohr Hamiltonian which originates from a SO(5) in- variance. A better understanding of inertial flow is central to improving collective models, particularly hydrodynamic-based collective models. The results suggest that a better description of collective dynamics and inertial flow for atomic nuclei is needed. The inclusion of vorticity degrees of freedom may provide a path forward. This is our first report of empirical moments of inertia for all three axes and the results should challenge both collective and microscopic descriptions of inertial flow.« less
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Mancuso, Raffaella; Maner, Asif; Ziccarelli, Ida; Pomelli, Christian; Chiappe, Cinzia; Della Ca', Nicola; Veltri, Lucia; Gabriele, Bartolo
2016-07-08
A convenient carbonylative approach to 2-oxazolidinone derivatives carried out using an ionic liquid (1-ethyl-3-methylimidazolium ethyl sulfate, EmimEtSO₄) as the solvent is presented. It is based on the sequential concatenation of two catalytic cycles, both catalyzed by the same metal species (auto-tandem catalysis): the first cycle corresponds to the oxidative monoaminocarbonylation of the triple bond of propargylic amines to give the corresponding 2-ynamide intermediates, while the second one involves the cyclocarbonylation of the latter to yield 2-(2-oxooxazolidin-5-ylidene)-acetamides. Reactions are carried out using a simple catalytic system consisting of PdI₂ in conjunction with an excess of KI, and the catalyst/solvent system could be recycled several times without appreciable loss of activity after extraction of the organic product with Et₂O.
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Effect of Boron Clusters on the Ignition Reaction of HNO3 and Dicynanamide-Based Ionic Liquids.
Schmidt, Michael W; Gordon, Mark S
2017-10-19
Many ionic liquids containing the dicynamide anion (DCA - , formula N(CN) 2 - ) exhibit hypergolic ignition when exposed to the common oxidizer nitric acid. However, the ignition delay is often about 10 times longer than the desired 5 ms for rocket applications, so that improvements are desired. Experiments in the past decade have suggested both a mechanism for the early reaction steps and also that additives such as decaborane can reduce the ignition delay. The mechanisms for reactions of nitric acid with both DCA - and protonated DCAH are considered here, using accurate wave function methods. Complexation of DCA - or DCAH with borane clusters B 10 H 14 or B 9 H 14 - is found to modify these mechanisms slightly by changing the nature of some of the intermediate saddle points and by small reductions in the reaction barriers.
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Melot, Brent C; Scanlon, David O; Reynaud, Marine; Rousse, Gwenaëlle; Chotard, Jean-Noël; Henry, Marc; Tarascon, Jean-Marie
2014-07-23
Li-ion batteries have enabled a revolution in the way portable consumer-electronics are powered and will play an important role as large-scale electrochemical storage applications like electric vehicles and grid-storage are developed. The ability to identify and design promising new positive insertion electrodes will be vital in continuing to push Li-ion technology to its fullest potential. Utilizing a combination of computational tools and structural analysis, we report new indicators which will facilitate the recognition of phases with the desired redox potential. Most importantly of these, we find there is a strong correlation between the presence of Li ions sitting in close-proximity to the redox center of polyanionic phases and the open circuit voltage in Fe-based cathodes. This common structural feature suggests that the bonding associated with Li may have a secondary inductive effect which increases the ionic character of Fe bonds beyond what is typically expected based purely on arguments of electronegativity associated with the polyanionic group. This correlation is supported by ab initio calculations which show the Bader charge increases (reflecting an increased ionicity) in a nearly linear fashion with the experimental cell potentials. These features are demonstrated to be consistent across a wide variety of compositions and structures and should help to facilitate the design of new, high-potential, and environmentally sustainable insertion electrodes.
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Wang, Yulei; Zhang, Jie; Huang, Xiaojia; Yuan, Dongxing
2014-08-20
In this work, a new stir cake sorptive extraction (SCSE) using polymeric ionic liquid monolith as sorbent was prepared. The sorbent was obtained by in situ copolymerization of an ionic liquid, 1-allyl-3-methylimidazolium bis[(trifluoro methyl)sulfonyl]imide (AMII) and divinylbenzene (DB) in the presence of N,N-dimethylformamide. The influence of the content of ionic liquid and the porogen in the polymerization mixture on extraction performance was studied thoroughly. The physicochemical properties of the polymeric ionic liquid were characterized by infrared spectroscopy, elemental analysis, scanning electron microscopy and mercury intrusion porosimetry. The usefulness of SCSE-AMIIDB was demonstrated by the enrichment of trace benzimidazole anthelmintics. Several parameters affecting the extraction efficiency were investigated, and under the optimized conditions, a simple and effective method for the determination of trace benzimidazoles residues in water, milk and honey samples was established by coupling SCSE-AMIIDB with high performance liquid chromatography/diode array detection (SCSE-AMIIDB-HPLC/DAD). Results indicated that the limits of detection (S/N=3) for target compounds were 0.020-0.072 μg L(-1), 0.035-0.10 μg L(-1) and 0.026-0.076 μg L(-1) in water, milk and honey samples, respectively. In addition, an acceptable reproducibility was achieved by evaluating the repeatability and intermediate precision with relative standard deviations (RSD) of less than 9% and 11%, respectively. Finally, the established AMII-SCSE-HPLC/DAD method was successfully applied for the determination of benzimidazoles residues in milk, honey and environmental water samples. Recoveries obtained for the determination of benzimidazole anthelmintics in spiking samples ranged from 70.2% to 117.6%, with RSD below 12% in all cases. Copyright © 2014 Elsevier B.V. All rights reserved.
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Tanaka, K; Sugiura, H; Uehara, M; Hashimoto, Y; Donnelly, C; Montgomery, D S
2001-10-01
The genetic background of atopic eczema might be heterogeneous and there is a possibility that immunoglobulin (Ig)E responsiveness in patients with atopic eczema is controlled separately from the development of atopic eczema. Although both interleukin (IL)-4 and the IL-4 receptor alpha chain have an important role for IgE production and are therefore possible candidate genes for atopy, it has not been clarified whether these genes play any roles in atopic eczema patients who have normal IgE productivity. We aimed to assess whether the polymorphisms of the IL-4 gene and the IL-4 receptor alpha chain gene play any roles in atopic eczema patients, particularly in patients who have normal IgE productivity. We determined the genotype with regard to polymorphisms in the genes for IL-4 and the IL-4 receptor alpha chain (- 589C/T of IL-4; Ile50Val, Ala375Glu and Arg551Gln of IL-4 receptor alpha chain) in patients with atopic eczema using the fluorogenic 5' nuclease assay. IL-4 and the IL-4 receptor alpha chain genotypes were not significantly associated with either total patients with atopic eczema or atopic eczema patients who had normal IgE productivity. The distribution of genotypes of IL-4-589C/T differed by the serum IgE levels in patients with atopic eczema. These results suggest that the polymorphisms in the IL-4 gene and the IL-4 receptor alpha chain gene play no role in the development of atopic eczema in patients who have normal IgE productivity.
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Zielnik-Jurkiewicz, Beata; Stankiewicz-Szymczak, Wanda
2016-06-01
Chronic otitis media with effusion (OME) is associated with irreversible changes in the middle ear, sometimes leading to hearing loss and abnormal language development in children. While the pathogenesis of OME is not fully understood, inflammatory and allergic factors are thought to be involved. The study aimed to investigate the role of cytokines in the local development of chronic OME, and assess differences in the cytokine profiles between atopic and non-atopic children. 84 atopic and non-atopic children with chronic OME (mean age of 6 years 7 months) were studied. Age-matched children with hypertrophy of the adenoids and Eustachian tube dysfunction served as the control group. The number of past acute otitis media (AOM) episodes, their age, and the type of effusion were recorded for all children. Pro-inflammatory cytokine concentrations (TNF-α, IL-1β, IL-6 and IL-8) were determined and the presence of pathogenic bacteria in the patients' effusions was examined. High concentrations of TNF-α, IL-1β, IL-6 and IL-8 were found in the effusions in all children with chronic OME, with the highest levels observed in the non-atopic group. The atopic group showed persistently high IL-1β levels, while in the non-atopic children, IL-1β and TNF-α levels positively correlated with the patient's age and the number of past AOM episodes. Pathogenic bacteria were more frequently isolated from effusions in non-atopic children. In both atopic and non-atopic children, pro-inflammatory cytokines are found at high concentrations. This argues in favor of instituting anti-inflammatory management for treating OME, regardless of atopy.
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Kapoor, Utkarsh; Shah, Jindal K
2018-01-11
Segregation of polar and nonpolar domains in ionic liquids for which either the cation or anion is responsible for inducing nonpolar domains is well understood. On the other hand, information regarding the nanoscale heterogeneities originating due to the presence of nonpolar content on both the ions is rudimentary at this point. The present contribution is aimed at addressing this question and focuses on a molecular dynamics simulation study to probe nanoscale structural and aggregation features of the 1-n-alkyl-3-methylimidazolium [C n mim] octylsulfate [C 8 SO 4 ] ionic liquid homologous series (n = 2, 4, 6, 8, 10, and 12). The objective of this work is to determine the effect of increasing alkyl chain length in the cation on nonpolar domain formation, especially when the alkyl chain lengths from both the ions participate in defining such domains. The results indicate that all the ionic liquids form nonpolar domains, morphology of which gradually changes from globular, sponge-like to layer-like structure with increase in the cationic alkyl chain length. The length of the nonpolar domains calculated from the total structure factor for [C 10 mim][C 8 SO 4 ] is considerably higher than that reported for other imidazolium-based ionic liquid containing smaller anions. The structure factor for [C 12 mim][C 8 SO 4 ] ionic liquid contains multiple intermediate peaks separating the charge alternation peak and pre-peak, which points to nonpolar domains of varying lengths, an observation that remains to be validated. Analysis of the heterogeneous order parameters and orientational correlation functions of the alkyl chains further suggests an increase in the spatial heterogeneity and long-range order along the homologous series. The origin of rich diversity of structures obtained by introducing nonpolar content on both the ions is discussed.
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O'Neill, Jenna L; Chan, Yiong Huak; Rapp, Stephen R; Yosipovitch, Gil
2011-09-01
Differences in itch characteristics between different inflammatory dermatoses are not well described. The aim of this study was to assess differences in itch characteristics between patients with psoriasis and atopic dermatitis using a previously validated web-based questionnaire that was made available through the National Psoriasis Foundation and National Eczema Association for Science and Education websites. Participants rated frequency and intensity of itch, associated symptoms, itch descriptors, and effect of scratching. A total of 524 subjects with atopic dermatitis and 195 subjects with psoriasis completed the survey. Atopic dermatitis responders experienced more frequent and more intense itch. Associated sweating and heat sensation were also more common in atopic dermatitis. Scratching was considered pleasurable in both atopic dermatitis and psoriasis; pleasurability correlated weakly with itch intensity in atopic dermatitis. Psoriasis respondents reported higher embarrassment associated with itch. Itch sensation is experienced differently among patients with atopic dermatitis and psoriasis. Future therapeutic interventions may be developed to target these differences.
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Influences of Environmental Chemicals on Atopic Dermatitis.
Kim, Kwangmi
2015-06-01
Atopic dermatitis is a chronic inflammatory skin condition including severe pruritus, xerosis, visible eczematous skin lesions that mainly begin early in life. Atopic dermatitis exerts a profound impact on the quality of life of patients and their families. The estimated lifetime prevalence of atopic dermatitis has increased 2~3 fold during over the past 30 years, especially in urban areas in industrialized countries, emphasizing the importance of life-style and environment in the pathogenesis of atopic diseases. While the interplay of individual genetic predisposition and environmental factors contribute to the development of atopic dermatitis, the recent increase in the prevalence of atopic dermatitis might be attributed to increased exposure to various environmental factors rather than alterations in human genome. In recent decades, there has been an increasing exposure to chemicals from a variety of sources. In this study, the effects of various environmental chemicals we face in everyday life - air pollutants, contact allergens and skin irritants, ingredients in cosmetics and personal care products, and food additives - on the prevalence and severity of atopic dermatitis are reviewed.
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Electron impact excitation of molecular hydrogen
Zammit, Mark Christian; Savage, Jeremy S.; Fursa, Dmitry V.; ...
2017-02-06
Here, we report the electron impact integrated and differential cross sections for excitation to the b 3Σmore » $$+\\atop{u}$$, a 3Σ$$+\\atop{g}$$, c 3Π u, B 1Σ$$+\\atop{u}$$, E, F 1Σ$$+\\atop{g}$$, C 1Π u, e 3Σ$$+\\atop{u}$$, h 3Σ $$+\\atop{g}$$, d 3Π u, B'' 1Σ$$+\\atop{u}$$ , D 1Π u, B'' 1Σ$$+\\atop{u}$$, and D' 1Π u states of molecular hydrogen in the energy range from 10 to 300 eV. Total scattering and total ionization cross sections are also presented. The calculations have been performed by using the convergent close-coupling method within the fixed-nuclei approximation. Detailed convergence studies have been performed with respect to the size of the close-coupling expansion and a set of recommended cross sections has been produced. Significant differences with previous calculations are found. Agreement with experiment is mixed, ranging from excellent to poor depending on the transition and incident energies.« less
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The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma
Bantz, Selene K.; Zhu, Zhou; Zheng, Tao
2014-01-01
The development of atopic dermatitis (AD) in infancy and subsequent allergic rhinitis and asthma in later childhood is known as the atopic march. This progressive atopy is dependent on various underlying factors such as the presence of filaggrin mutations as well as the time of onset and severity of AD. Clinical manifestations vary among individuals. Previously it was thought that atopic disorders may be unrelated with sequential development. Recent studies support the idea of a causal link between AD and later onset atopic disorders. These studies suggest that a dysfunctional skin barrier serves as a site for allergic sensitization to antigens and colonization of bacterial super antigens. This induces systemic Th2 immunity that predisposes patients to allergic nasal responses and promotes airway hyper reactivity. While AD often starts early in life and is a chronic condition, new research signifies that there may be an optimal window of time in which targeting the skin barrier with therapeutic interventions may prevent subsequent atopic disorders. In this review we highlight recent studies describing factors important in the development of atopic disorders and new insights in our understanding of the pathogenesis of the atopic march. PMID:25419479
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Nickel allergy and relationship with Staphylococcus aureus in atopic dermatitis.
Bogdali, Anna M; Anna, Bogdali M; Grazyna, Antoszczyk; Wojciech, Dyga; Aleksander, Obtulowicz; Anna, Bialecka; Andrzej, Kasprowicz; Zofia, Magnowska; Krystyna, Obtulowicz
2016-01-01
The increase of nickel air pollution is supposed to frequent side effects of nickel action related to virulence potential of Staphylococcus aureus in patients with nickel allergy in atopic dermatitis. The goal was to investigate the relationship between nickel allergy and infection by S. aureus in atopic dermatitis. Nickel allergy was confirmed in atopic patients and excluded in healthy volunteers using patch testing. Infection by S. aureus was tested in atopic patients and healthy volunteers by use of API Staph system. The specific IgE for staphylococcal enterotoxin A and B were measured. Secretion of IFN-g, IL-2, IL-13 by PBMC under nickel sulfate and the enterotoxins A and B stimulations were studied with ELISpot. We found the increased number of infections by S. aureus in atopic patients with nickel allergy in comparison to atopic patients and healthy volunteers without nickel allergy. The elevated secretion of IL-2 under nickel sulfate stimulation in vitro was exclusively found in atopic patients with nickel allergy infected by S. aureus. Our data suggest that nickel allergy and infection by S. aureus are linked in atopic dermatitis. Copyright © 2015 Elsevier GmbH. All rights reserved.
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Simonsen, A B; Johansen, J D; Deleuran, M; Mortz, C G; Skov, L; Sommerlund, M
2018-03-01
Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in atopic dermatitis (AD) facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in children with atopic dermatitis. To determine the prevalence of contact allergy in Danish children with atopic dermatitis and explore the problem of unacknowledged allergies maintaining or aggravating the skin symptoms. In a cross-sectional study, 100 children and adolescents aged 5-17 years with a diagnosis of atopic dermatitis were patch tested with a paediatric series of 31 allergens. Thirty per cent of the children had at least one positive patch test reaction, and 17% had at least one contact allergy that was relevant to the current skin symptoms. The risk of contact allergy was significantly correlated to the severity of atopic dermatitis. Metals and components of topical skincare products were the most frequent sensitizers. Patch testing is relevant as a screening tool in the management of children with atopic dermatitis as they may have unacknowledged contact allergies contributing to or maintaining their skin symptoms. Children with atopic dermatitis seem to be at greater risk of sensitization to certain allergens including metals and components of skincare products. © 2017 European Academy of Dermatology and Venereology.
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Economic Impact of Atopic Dermatitis in Korean Patients
Kim, Chulmin; Park, Kui Young; Ahn, Seohee; Kim, Dong Ha; Li, Kapsok; Kim, Do Won; Kim, Moon-Beom; Jo, Sun-Jin; Yim, Hyeon Woo
2015-01-01
Background Atopic dermatitis is a global public health concern owing to its increasing prevalence and socioeconomic burden. However, few studies have assessed the economic impact of atopic dermatitis in Korea. Objective We conducted a cost analysis of atopic dermatitis and evaluated its economic impacts on individual annual disease burden, quality of life, and changes in medical expenses with respect to changes in health related-quality of life. Methods The cost analysis of atopic dermatitis was performed by reviewing the home accounting records of 32 patients. The economic impact of the disease was evaluated by analyzing questionnaires. To handle uncertainties, we compared the results with the data released by the Health Insurance Review & Assessment Board on medical costs claimed by healthcare facilities. Results The direct cost of atopic dermatitis per patient during the 3-month study period was 541,280 Korean won (KRW), and expenditures on other atopic dermatitis-related products were 120,313 KRW. The extrapolated annual direct cost (including expenditures on other atopic dermatitis-related products) per patient was 2,646,372 KRW. The estimated annual indirect cost was 1,507,068 KRW. Thus, the annual cost of illness of atopic dermatitis (i.e., direct+indirect costs) was estimated to be 4,153,440 KRW. Conclusion The annual total social cost of atopic dermatitis on a national level is estimated to be 5.8 trillion KRW. PMID:26082587
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Management of Patients with Atopic Dermatitis: The Role of Emollient Therapy
Catherine Mack Correa, M.; Nebus, Judith
2012-01-01
Atopic dermatitis is a common inflammatory skin disorder that afflicts a growing number of young children. Genetic, immune, and environmental factors interact in a complex fashion to contribute to disease expression. The compromised stratum corneum found in atopic dermatitis leads to skin barrier dysfunction, which results in aggravation of symptoms by aeroallergens, microbes, and other insults. Infants—whose immune system and epidermal barrier are still developing—display a higher frequency of atopic dermatitis. Management of patients with atopic dermatitis includes maintaining optimal skin care, avoiding allergic triggers, and routinely using emollients to maintain a hydrated stratum corneum and to improve barrier function. Flares of atopic dermatitis are often managed with courses of topical corticosteroids or calcineurin inhibitors. This paper discusses the role of emollients in the management of atopic dermatitis, with particular emphasis on infants and young children. PMID:23008699
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Boleira, Manuela; Lupi, Omar; Pires, Gisele Vianna; Dias, Gabriela; Seba, Amanda Jaccobson; Guimarães, Daniel Boleira Sieiro
2014-01-01
BACKGROUND atopic dermatitis is directly related to psychological stress, reduced quality of life and psychosomatic symptoms. The Psychosomatic Scale for Atopic Dermatitis is the only questionnaire developed specifically for assessment of psychosomatization in atopic dermatitis. OBJECTIVES the objective of this study was to cross-culturally adapt and validate a Brazilian-Portuguese version of the Psychosomatic Scale for Atopic Dermatitis. METHODS adaptation consisted of independent translation and backtranslation by three bilingual translators, followed by a pre-test. The Psychosomatic Scale for Atopic Dermatitis and the Dermatology Life Quality Index were self-administered to 47 patients with atopic dermatitis. Disease severity was evaluated using the Eczema Area and Severity Index. Factor analysis was used to identify the dimensions of the Brazilian Portuguese version of the Psychosomatic Scale for Atopic Dermatitis. Internal consistency and convergence validity were also analyzed. Reproducibility was assessed using the Kappa coefficient. RESULTS factor analysis revealed a two-dimensional structure: stress/laziness/insecurity (I) and maladjustment/social relationships (II), explaining 54.4% of total variance. All dimensions revealed excellent internal consistency. External construct validity was confirmed by positive correlations between the Psychosomatic Scale for Atopic Dermatitis and the Dermatology Life Quality Index. Test-retest reliability was excellent, with k>0.7 for all questions. CONCLUSIONS the Brazilian Portuguese version of the Psychosomatic Scale for Atopic Dermatitis demonstrated acceptable psychometric properties and can be used for the evaluation of psychosomatic symptoms in patients with atopic dermatitis and as a tool in clinical and epidemiological research. PMID:25184916
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Miyake, Yoshihiro; Sasaki, Satoshi; Tanaka, Keiko; Ohya, Yukihiro; Matsunaga, Ichiro; Yoshida, Toshiaki; Hirota, Yoshio; Oda, Hajime
2008-01-01
Dietary factors may be important in the development of atopic eczema. It remains controversial whether n-3 polyunsaturated fatty acid intake is preventive against allergic disorders and whether n-6 polyunsaturated fatty acid intake increases the risk of allergic disorders. The current cross-sectional study examined the association between intake of fatty acids and foods high in fatty acids and the prevalence of atopic eczema. Study subjects were 1002 pregnant Japanese females. Current atopic eczema and atopic eczema after age 18 were defined as present if subjects had been treated with medications at some time in the previous 12 months and after reaching the age of 18, respectively. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Docosahexaenoic acid intake was statistically significantly related to a decreased prevalence of atopic eczema after age 18 and current atopic eczema. Inverse dose-response relationships with regard to consumption of n-3 polyunsaturated fatty acids, eicosapentaenoic acid, and fish and the ratio of n-3 to n-6 polyunsaturated fatty acids with atopic eczema were not observed although these dietary variables in the second tertile were inversely significantly associated with atopic eczema after age 18. Intake of total fat, saturated fatty acids, monounsaturated fatty acids, n-6 polyunsaturated fatty acids, cholesterol, meat, eggs, or dairy products was not related to either of the outcomes for atopic eczema. Docosahexaenoic acid intake may be associated with a reduced prevalence of atopic eczema in pregnant Japanese females.
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Is Patch Testing with Food Additives Useful in Children with Atopic Eczema?
Catli, Gonul; Bostanci, Ilknur; Ozmen, Serap; Dibek Misirlioglu, Emine; Duman, Handan; Ertan, Ulker
2015-01-01
Atopy patch testing is a useful way to determine delayed-type hypersensitivity reactions to foods and aeroallergens. Although food additives have been accused of worsening atopic eczema symptoms, according to recent studies the role of food additives in atopic eczema remains unclear. The purpose of our study was to investigate food additive hypersensitivity in a group of children with atopic eczema by using standardized atopy patch testing and to determine the role of food additive hypersensitivity in atopic eczema. Thirty-four children with atopic eczema and 33 healthy children were enrolled in the study. Children who consumed foods containing additives and did not use either antihistamines or local or systemic corticosteroids for at least 7 days prior to admission were enrolled in the study. All children were subjected to atopy patch testing and after 48 and 72 hours their skin reactions were evaluated by using the guidelines. Positive atopy patch test results were significantly higher in the atopic eczema group. Forty-one percent of the atopic eczema group (n = 14) and 15.2% (n = 5) of the control group had positive atopy patch test results with food additives (p = 0.036) (estimated relative risk 1.68, case odds 0.7, control odds 0.17). Carmine hypersensitivity and the consumption of foods containing carmine, such as gumdrops, salami, and sausage, were significantly higher in the children with atopic eczema. This is the first study investigating hypersensitivity to food additives in children with atopic eczema. Our results indicate that carmine may play a role in atopic eczema. © 2015 Wiley Periodicals, Inc.
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Mixed ionic-electronic conductors for electrodes of barium cerate-based SOFCS
NASA Astrophysics Data System (ADS)
Wu, Zhonglin
Gadolinium doped barium cerates (BCGs) have been identified as promising electrolyte materials for intermediate-temperature solid oxide fuel cells (SOFCs). It is crucial to develop compatible electrode materials for such electrolytes. Mixed ionic-electronic conductor (MIEC) electrode materials developed for SOFCs based on yttrium-stabilized zirconia (YSZ) may be used as electrode materials for BCG-based SOFCs; but a careful re-evaluation is required due to the intrinsic differences between BCG and YSZ. The performance of these electrode materials depends critically the transport of ionic and electronic species as well as gas. Accordingly, a profound understanding of transport in MIEC electrodes is imperative to effective design of high performance SOFCs. In this thesis, ambipolar transport in composite MIEC electrodes has been modeled using percolation theory to predict the effect of volume fractions of constituent phases and porosity on ambipolar conductivity. Transport and electrode kinetics of homogeneous MIEC electrodes have also been formulated under a steady-state condition to predict the distributions of ionic defects and current carried by each defect in such electrodes. Effects of catalytic properties, transport properties, and microstructure of porous electrodes and interfaces on the electrode performance are investigated. Under the guidelines of the theoretical modeling, several MIEC electrode materials are developed. Lasb{1-x}Srsb{x}Cosb{1-x}Fesb{y}Osb{3-delta} homogeneous materials are studied as cathode materials. However, the interfacial resistance seems too high due to the lack of catalytic activity at intermediate temperatures. Results indicate that Ag-Bisb{1.5}Ysb{0.5}Osb3 composite MIECs are good cathode materials when the volume fractions of constituent phases and porosity are carefully controlled. Such electrodes have low interfacial resistance, better binding strength, and smaller thermal mismatch with the BCG electrolyte, compared to other metal electrodes (such as Pt and Ag). Ni-BCG composite MIECs are studied as anode materials. It is found that electrodes prepared from NiO and reduced to Ni in situ is not catalytically active because of diffusion of NiO into BCG, which forms a resistive layer. Electrodes prepared from Ni metal and fired in an inert or reducing atmosphere exhibit low interfacial resistance and good compatibility with BCG electrolyte. Stability of these developed electrode materials is investigated under conditions pertinent to SOFCs.
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Nonhumidified intermediate temperature fuel cells using protic ionic liquids.
Lee, Seung-Yul; Ogawa, Atsushi; Kanno, Michihiro; Nakamoto, Hirofumi; Yasuda, Tomohiro; Watanabe, Masayoshi
2010-07-21
In this paper, the characterization of a protic ionic liquid, diethylmethylammonium trifluoromethanesulfonate ([dema][TfO]), as a proton conductor for a fuel cell and the fabrication of a membrane-type fuel cell system using [dema][TfO] under nonhumidified conditions at intermediate temperatures are described in detail. In terms of physicochemical and electrochemical properties, [dema][TfO] exhibits high activity for fuel cell electrode reactions (i.e., the hydrogen oxidation reaction (HOR) and oxygen reduction reaction (ORR)) at a Pt electrode, and the open circuit voltage (OCV) of a liquid fuel cell is 1.03 V at 150 degrees C, as has reported in ref 27. However, diethylmethylammonium bis(trifluoromethane sulfonyl)amide ([dema][NTf(2)]) has relatively low HOR and ORR activity, and thus, the OCV is ca. 0.7 V, although [dema][NTf(2)] and [dema][TfO] have an identical cation ([dema]) and similar thermal and bulk-transport properties. Proton conduction occurs mainly via the vehicle mechanism in [dema][TfO] and the proton transference number (t(+)) is 0.5-0.6. This relatively low t(+) appears to be more disadvantageous for a proton conductor than for other electrolytes such as hydrated sulfonated polymer electrolyte membranes (t(+) = 1.0). However, fast proton-exchange reactions occur between ammonium cations and amines in a model compound. This indicates that the proton-exchange mechanism contributes to the fuel cell system under operation, where deprotonated amines are continuously generated by the cathodic reaction, and that polarization of the cell is avoided. Six-membered sulfonated polyimides in the diethylmethylammonium form exhibit excellent compatibility with [dema][TfO]. The composite membranes can be obtained up to a [dema][TfO] content of 80 wt % and exhibit good thermal stability, high ionic conductivity, and mechanical strength and gas permeation comparable to those of hydrated Nafion. H(2)/O(2) fuel cells prepared using the composite membranes can successfully operate at temperatures from 30 to 140 degrees C under nonhumidified conditions, and a current density of 250 mA cm(-2) is achieved at 120 degrees C. The protic ionic liquid and its composite membrane are a possible candidate for an electrolyte of a H(2)/O(2) fuel cell that operates under nonhumidified conditions.
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Can atopic dermatitis be prevented?
Gómez-de la Fuente, E
2015-05-01
Atopic dermatitis has become a health problem in our setting due to its rising prevalence, impact on quality of life, associated costs, and role in the progression to other atopic diseases. Furthermore, atopic dermatitis has no definitive cure and therefore preventive measures are important. In this article, we review the latest advances in both primary prevention (reduction of the incidence of atopic dermatitis) and secondary prevention (reduction of associated morbidity and reduction of the atopic march). We analyze the different preventive strategies available, including modification of the immune system through microbial exposure, induction of immune tolerance through antigen exposure, and restoration of skin barrier function to halt the atopic march. Dermatologists need to be familiar with these strategies in order to apply them where necessary and to accurately inform patients and their relatives to prevent misguided or inappropriate actions. Copyright © 2014 Elsevier España, S.L.U. and AEDV. All rights reserved.
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Juhn, Young J.; Wi, Chung-Il
2014-01-01
Otitis media is the most common infection second only to viral upper respiratory infection in the outpatient setting. Tympanostomy tube insertion (TTI) is the most common ambulatory surgical procedure in the United States. While many risk factors for otitis media have been identified, atopic conditions have been under-recognized as risk factors for recurrent and persistent otitis media. Given that asthma and other atopic conditions are the most common chronic conditions during childhood, it is worth examining the association between atopic conditions and risk of otitis media, which can provide insight into how atopic conditions influence the risk of microbial infections. This paper focuses its discussion on otitis media, however it is important that the association between atopic conditions and risk of otitis media be interpreted in the context of the association of atopic conditions with increased risks of various microbial infections. PMID:24816652
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Thompson, Christopher; Vanhatalo, Anni; Kadach, Stefan; Wylie, Lee J; Fulford, Jonathan; Ferguson, Scott K; Blackwell, Jamie R; Bailey, Stephen J; Jones, Andrew M
2018-06-01
The physiological and exercise performance adaptations to sprint interval training (SIT) may be modified by dietary nitrate ([Formula: see text]) supplementation. However, it is possible that different types of [Formula: see text] supplementation evoke divergent physiological and performance adaptations to SIT. The purpose of this study was to compare the effects of 4-wk SIT with and without concurrent dietary [Formula: see text] supplementation administered as either [Formula: see text]-rich beetroot juice (BR) or potassium [Formula: see text] (KNO 3 ). Thirty recreationally active subjects completed a battery of exercise tests before and after a 4-wk intervention in which they were allocated to one of three groups: 1) SIT undertaken without dietary [Formula: see text] supplementation (SIT); 2) SIT accompanied by concurrent BR supplementation (SIT + BR); or 3) SIT accompanied by concurrent KNO 3 supplementation (SIT + KNO 3 ). During severe-intensity exercise, V̇o 2peak and time to task failure were improved to a greater extent with SIT + BR than SIT and SIT + KNO 3 ( P < 0.05). There was also a greater reduction in the accumulation of muscle lactate at 3 min of severe-intensity exercise in SIT + BR compared with SIT + KNO 3 ( P < 0.05). Plasma [Formula: see text] concentration fell to a greater extent during severe-intensity exercise in SIT + BR compared with SIT and SIT + KNO 3 ( P < 0.05). There were no differences between groups in the reduction in the muscle phosphocreatine recovery time constant from pre- to postintervention ( P > 0.05). These findings indicate that 4-wk SIT with concurrent BR supplementation results in greater exercise capacity adaptations compared with SIT alone and SIT with concurrent KNO 3 supplementation. This may be the result of greater NO-mediated signaling in SIT + BR compared with SIT + KNO 3 . NEW & NOTEWORTHY We compared the influence of different forms of dietary nitrate supplementation on the physiological and performance adaptations to sprint interval training (SIT). Compared with SIT alone, supplementation with nitrate-rich beetroot juice, but not potassium [Formula: see text], enhanced some physiological adaptations to training.
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Evidence for a $$B_s^0 \\pi^\\pm$$ state
DOE Office of Scientific and Technical Information (OSTI.GOV)
Abazov, V. M.
Here, we report evidence for a narrow structure, X(5568), in the decay sequence X(5568)→more » $$B_s^0 \\pi^\\pm$$, B$$_s^0$$ →J/ψΦ, J/ψ→μ+μ-, Φ→K+K-. This is evidence for the first instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m=5567.8±2.9(stat) $$+0.9\\atop{-1.9}$$ (syst) MeV/c 2 and Γ=21.9±6.4(stat)$$+5.0\\atop{-2.5}$$ (syst) MeV/c 2. If the decay is X(5568)→B$$*\\atop{s}$$ π ±→B$$0\\atop{s}$$ γπ ± with an unseen γ, m(X(5568)) will be shifted up by m(B$$*\\atop{s}$$ )-m(B$$0\\atop{s}$$)~49 MeV/c 2. This measurement is based on 10.4 fb -1 of $$p\\bar{p}$$ collision data at $$\\sqrt{s}$$ =1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider.« less
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Tanaka, K; Sugiura, H; Uehara, M; Sato, H; Hashimoto-Tamaoki, T; Furuyama, J
1999-06-01
It has remained unclear whether genetic background of patients with atopic eczema (AE) alone is identical to that of patients with both AE and atopic respiratory disease. We aimed to assess whether there is a genetic difference between these two groups of AE patients. We determined the genotype with regard to an allelic polymorphism in the gene for mast cell chymase (MCC; a serine protease secreted from mast cells) in 169 AE patients. MCC genotype was significantly associated with pure AE patients who did not have a predisposition to atopic respiratory disease and whose serum IgE concentration was < 500 IU/mL. The distribution of MCC genotypes also differed significantly between the latter patients and those AE patients with bronchial asthma and a serum IgE concentration of > 2000 IU/mL. These results suggest that pure AE is associated with genetic variants of MCC, and that the genetic basis of pure AE differs from that of AE associated with atopic asthma.
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Evidence for a $$B_s^0 \\pi^\\pm$$ state
Abazov, V. M.
2016-07-07
Here, we report evidence for a narrow structure, X(5568), in the decay sequence X(5568)→more » $$B_s^0 \\pi^\\pm$$, B$$_s^0$$ →J/ψΦ, J/ψ→μ+μ-, Φ→K+K-. This is evidence for the first instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m=5567.8±2.9(stat) $$+0.9\\atop{-1.9}$$ (syst) MeV/c 2 and Γ=21.9±6.4(stat)$$+5.0\\atop{-2.5}$$ (syst) MeV/c 2. If the decay is X(5568)→B$$*\\atop{s}$$ π ±→B$$0\\atop{s}$$ γπ ± with an unseen γ, m(X(5568)) will be shifted up by m(B$$*\\atop{s}$$ )-m(B$$0\\atop{s}$$)~49 MeV/c 2. This measurement is based on 10.4 fb -1 of $$p\\bar{p}$$ collision data at $$\\sqrt{s}$$ =1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider.« less
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Influences of Environmental Chemicals on Atopic Dermatitis
2015-01-01
Atopic dermatitis is a chronic inflammatory skin condition including severe pruritus, xerosis, visible eczematous skin lesions that mainly begin early in life. Atopic dermatitis exerts a profound impact on the quality of life of patients and their families. The estimated lifetime prevalence of atopic dermatitis has increased 2~3 fold during over the past 30 years, especially in urban areas in industrialized countries, emphasizing the importance of life-style and environment in the pathogenesis of atopic diseases. While the interplay of individual genetic predisposition and environmental factors contribute to the development of atopic dermatitis, the recent increase in the prevalence of atopic dermatitis might be attributed to increased exposure to various environmental factors rather than alterations in human genome. In recent decades, there has been an increasing exposure to chemicals from a variety of sources. In this study, the effects of various environmental chemicals we face in everyday life - air pollutants, contact allergens and skin irritants, ingredients in cosmetics and personal care products, and food additives - on the prevalence and severity of atopic dermatitis are reviewed. PMID:26191377
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Ring, J; Palos, E
1986-11-01
To evaluate the style of education in this group of children, "scale versions" according to Stapf were used. Mothers of atopic children were found to be significantly more "strict" in their educational approach compared with control mothers (P less than 0.01). There was no significant difference between the two groups of fathers. In particular, mothers of atopic children significantly more often favored "grown-up" behavior in their children and the capacity to enjoy the joy of children was significantly less pronounced compared with controls. In the children's drawings, children with atopic eczema lacked the "friendly atmosphere" expressed in drawings of control children. Fathers of atopic children were drawn significantly smaller than the respective mothers. In animal drawings, children with atopic eczema mostly selected unpleasant or dangerous animals to describe their parents, brothers, or sisters. From the structured interviews, the following points were remarkable: atopic children more often display aggressive thoughts or behavior against their parents than do controls. Mothers of atopic children react less spontaneously and less emotionally to children's emotions. Maternal affection often takes place as a hygienic ritual or in a body and achievement-oriented fashion. Mothers of atopic children like them to behave in a "grown-up" manner.
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Schmitt, Jochen; Spuls, Phyllis; Boers, Maarten; Thomas, Kim; Chalmers, Joanne; Roekevisch, Evelien; Schram, Mandy; Allsopp, Richard; Aoki, Valeria; Apfelbacher, Christian; Bruijnzeel-Koomen, Carla; Bruin-Weller, Marjolein; Charman, Carolyn; Cohen, Arnon; Dohil, Magdalene; Flohr, Carsten; Furue, Masutaka; Gieler, Uwe; Hooft, Lotty; Humphreys, Rosemary; Ishii, Henrique Akira; Katayama, Ichiro; Kouwenhoven, Willem; Langan, Sinéad; Lewis-Jones, Sue; Merhand, Stephanie; Murota, Hiroyuki; Murrell, Dedee F; Nankervis, Helen; Ohya, Yukihiro; Oranje, Arnold; Otsuka, Hiromi; Paul, Carle; Rosenbluth, Yael; Saeki, Hidehisa; Schuttelaar, Marie-Louise; Stalder, Jean-Francois; Svensson, Ake; Takaoka, Roberto; Wahlgren, Carl-Fredrik; Weidinger, Stephan; Wollenberg, Andreas; Williams, Hywel
2012-09-01
The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from 10 countries, representing different stakeholders (patients, clinicians, methodologists, pharmaceutical industry) to determine core outcome domains for atopic eczema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics for atopic eczema outcomes research. Delegates were given evidence-based information, followed by structured group discussion and anonymous consensus voting. Consensus was achieved to include clinical signs, symptoms, long-term control of flares and quality of life into the core set of outcome domains for atopic eczema trials. The HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic eczema trials. Measures of these core outcome domains need to be valid, sensitive to change and feasible. Prioritized topics of the HOME initiative are the identification/development of the most appropriate instruments for the four core outcome domains. HOME is open to anyone with an interest in atopic eczema outcomes research. © 2012 John Wiley & Sons A/S.
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Atopic Dermatitis and Comorbidities: Added Value of Comprehensive Dermatoepidemiology.
Nijsten, Tamar
2017-05-01
Atopic dermatitis is common and in its severe form is devastating. This chronic inflammatory dermatosis is part of the atopic syndrome, which includes asthma, food allergies, and hay fever and is known to be associated with mental health disorders. In line with psoriasis, several recent observational studies using national survey and linkage data have suggested a link between atopic dermatitis and cardiovascular disease. The atopic dermatitis field can benefit from the past experiences in psoriasis research and should not follow the same path, but, rather, aim for a more comprehensive approach from the beginning. A recent German consortium studying links between atopic dermatitis and cardiovascular disease first screened a large claims database, followed by analyses of more deeply phenotyped (birth) cohorts with longitudinal data. In addition, genetic and metabolic analyses assessing the predisposition of patients with atopic dermatitis for cardiovascular disease were performed. Overall, the association between atopic dermatitis and cardiovascular disease was at most modest, but in more refined cohorts the cardiovascular risk profile and genetic architecture was comparable. A more integrated approach could create clarity about the clinical relevance of cardiovascular disease in individuals with atopic dermatitis sooner, avoid speculation that affects patient care, and save scientific resources. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
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Crack, L R; Chan, H W; McPherson, T; Ogg, G S
2011-11-01
Accumulating evidence suggests that T cells play an important role in the pathogenesis of atopic dermatitis (AD); yet, little is known of the differentiation status of CD4+ T cells specific for common environmental allergens, such as the major cat allergen, Fel d 1. To determine the frequency, differentiation phenotype and function of circulating Fel d 1-specific CD4+ T cells in adult individuals with severe persistent AD in comparison with healthy controls. Using HLA class II tetrameric complexes based on a HLA-DPB1*0401-restricted Fel d 1 epitope, ex vivo and cultured T cell frequency and phenotype were analysed in individuals with AD and healthy controls. Cytokine secretion was measured by ex vivo and cultured IL-4 and IFN-γ ELISpots. Ex vivo Fel d 1-specific DPB1*0401-restricted CD4+ T cells in both atopics and non-atopics express high levels of CCR7, CD62L, CD27 and CD28, placing the cells largely within the central memory subgroup. However, the functional phenotype was distinct, with greater IL-4 production from the cells derived from atopics, which correlated with disease severity. Circulating Fel d 1-specific DPB1*0401-restricted CD4+ T cells in both atopic and non-atopic donors maintain a central memory phenotype; however in atopics, the cells had greater Th2 effector function, compatible with a disease model of altered antigen delivery in atopic individuals. © 2011 Blackwell Publishing Ltd.
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Miyake, Yoshihiro; Ohya, Yukihiro; Tanaka, Keiko; Yokoyama, Tetsuji; Sasaki, Satoshi; Fukushima, Wakaba; Ohfuji, Satoko; Saito, Kyoko; Kiyohara, Chikako; Hirota, Yoshio
2007-08-01
Atopic eczema is most commonly diagnosed in children under the age of 5 yr. Environmental factors during pregnancy or in early life may confer risk for childhood atopic eczema. The present prospective study examined the relationship of the perinatal home environment and the risk of suspected atopic eczema among Japanese infants under the age of 1. Study subjects were 865 parent-child pairs. The term 'suspected atopic eczema' was used to define an outcome based on our questionnaire at 2-9 months postpartum. Adjustment was made for maternal age, gestation, family income, maternal and paternal education, maternal and paternal history of asthma, atopic eczema, and allergic rhinitis, time of delivery before the second survey, baby's older siblings, baby's sex, and baby's birth weight. A high mite allergen level from maternal bedclothes and mold in the kitchen during pregnancy were significantly associated with an increased risk of suspected atopic eczema. Frequent vacuuming practices during pregnancy and giving the infant a bath or shower at least once a day were significantly inversely related to the risk of suspected atopic eczema. Maternal smoking, maternal use of a synthetic duvet and pillow, carpet use in the living room and maternal bedroom, indoor domestic pets, no ducted heating appliance, and gas use for cooking during pregnancy and household smoking in the same room as the infant, infant's synthetic duvet, carpet use in the infant's room, or vacuuming the infant's room were not related to the risk of suspected atopic eczema. High house dust mite allergen levels and mold in the kitchen during pregnancy may increase the risk of infantile atopic eczema, whereas frequent vacuuming practices during pregnancy and giving the infant a bath or shower at least once a day may protect against infantile atopic eczema.
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Shu, X; Prochazka, M; Lannering, B; Schüz, J; Röösli, M; Tynes, T; Kuehni, C E; Andersen, T V; Infanger, D; Schmidt, L S; Poulsen, A H; Klaeboe, L; Eggen, T; Feychting, M
2014-04-01
A number of epidemiological studies indicate an inverse association between atopy and brain tumors in adults, particularly gliomas. We investigated the association between atopic disorders and intracranial brain tumors in children and adolescents, using international collaborative CEFALO data. CEFALO is a population-based case-control study conducted in Denmark, Norway, Sweden, and Switzerland, including all children and adolescents in the age range 7-19 years diagnosed with a primary brain tumor between 2004 and 2008. Two controls per case were randomly selected from population registers matched on age, sex, and geographic region. Information about atopic conditions and potential confounders was collected through personal interviews. In total, 352 cases (83%) and 646 controls (71%) participated in the study. For all brain tumors combined, there was no association between ever having had an atopic disorder and brain tumor risk [odds ratio 1.03; 95% confidence interval (CI) 0.70-1.34]. The OR was 0.76 (95% CI 0.53-1.11) for a current atopic condition (in the year before diagnosis) and 1.22 (95% CI 0.86-1.74) for an atopic condition in the past. Similar results were observed for glioma. There was no association between atopic conditions and risk of all brain tumors combined or of glioma in particular. Stratification on current or past atopic conditions suggested the possibility of reverse causality, but may also the result of random variation because of small numbers in subgroups. In addition, an ongoing tumor treatment may affect the manifestation of atopic conditions, which could possibly affect recall when reporting about a history of atopic diseases. Only a few studies on atopic conditions and pediatric brain tumors are currently available, and the evidence is conflicting.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Da Ronco, Saverio
2006-01-01
This thesis reports the reconstruction and lifetime measurement of B +, Bmore » $$0/atop{d}$$ and B$$0/atop{s}$$ mesons, performed using fully reconstructed hadronic decays collected by a dedicated trigger at CDF II experiment. This dedicated trigger selects significantly displaced tracks from primary vertex of p$$\\bar{p}$$ collisions generated at Tevatron collider, obtaining, in this way, huge data samples enriched of long-lived particles, and is therefore suitable for reconstruction of B meson in hadronic decay modes. Due to the trigger track impact parameter selections, the proper decay time distributions of the B mesons no longer follow a simply exponential decay law. This complicates the lifetime measurement and requires a correct understanding and treatment of all the involved effects to keep systematic uncertainties under control. This thesis presents a method to extract the lifetime of B mesons in “ct- biased” samples, based on a Monte Carlo approach, to correct for the effects of the trigger and analysis selections. We present the results of this method when applied on fully re- constructed decays of B collected by CDF II in the data taking runs up to August 2004, corresponding to an integrated luminosity of about 360 pb -1. The lifetimes are extracted using the decay modes B + → $$\\bar{D}$$ 0π +,B$$0\\atop{d}$$ → D -π +, B$$0\\atop{d}$$ → D -π +π -π +, B$$0\\atop{s}$$ → D$$-\\atop{s}$$π + and B$$0\\atop{s}$$ → D$$-\\atop{s}$$ π +π -π +(and c.c.) and performing combined mass-lifetime unbinned maximum likelihood fits.« less
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NASA Technical Reports Server (NTRS)
McGrath, William R. (Inventor); Lubecke, Victor M. (Inventor)
1992-01-01
A device for tuning a circuit includes a substrate, a transmission line on the substrate that includes first and second conductors coupled to a circuit to be tuned, and a movable short-circuit for varying the impedance the transmission line presents to the circuit to be tuned. The movable short-circuit includes a dielectric layer disposed atop the transmission line and a distributed shorting element in the form of a conductive member that is configured to be slid along at least a portion of the transmission line atop the dielectric layer. The conductive member is configured to span the first and second conductors of the transmission line and to define at least a first opening that spans the two conductors so that the conductive member includes first and second sections separated by the first opening. The first and second sections of the conductive member combine with the first and second conductors of the transmission line to form first and second low impedance sections of transmission line, and the opening combines with the first and second conductors of the transmission line and the dielectric layer to form a first high impedance section of transmission line intermediate the first and second low impedance sections. Each of the first low impedance section and the first high impedance section have a length along the transmission line of approximately one-quarter wavelength, thus providing a periodic variation of transmission line impedance. That enhances reflection of rf power.
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Oh, Won Oak; Im, YeoJin; Suk, Min Hyun
2016-11-01
Difficulty in sleep is one disturbing symptom in adolescents with atopic diseases including asthma, allergic rhinitis, and atopic dermatitis. Assuming psychological stress can affect adolescents' health status, impaired sleep quality can be one mediator that negatively impacts the health status of adolescents with atopic disease. This study aimed to identify the mediating effect of sleep satisfaction on the relationship between stress and perceived health status in Korean adolescents with atopic disease and to examine the differences among three types of atopic disease. A cross-sectional descriptive study was completed based on secondary analysis of raw data from the 2013 9th Korea Youth Risk Behavior Web-based Survey. The 21,154 adolescents (29.2%) ever diagnosed and treated for at least one atopic disease regardless of the symptom presence in a recent year were extracted out of 72,435 survey participants. Then, the 13,216 individuals with exclusively single atopic diseases were included in analyzing the mediation model. Variables including demographics, stress, perceived health status, and sleep satisfaction were included. Pearson correlation, one-way ANOVA, path analysis to define direct/indirect effects with bootstrapping analysis, and multi-group variance analysis were conducted. High levels of stress in adolescents with atopic diseases had a significant and direct effect on their negative health status perception for all atopic disease groups. A significant negative mediating effect of sleep satisfaction was identified on the relationship between stress and perceived health status, irrespective of the type of atopic disease. Total effect and remaining direct effect on the path from stress and perceived health status via sleep satisfaction was high in adolescents with atopic dermatitis and allergic rhinitis compared to those with asthma. To improve sleep satisfaction for adolescents with atopic diseases, interventions are needed to enhance the adolescents' perceived health status through stress reduction and sleep quality improvement. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Can, Ceren; Yazıcıoğlu, Mehtap; Gürkan, Hakan; Tozkır, Hilmi; Görgülü, Adnan; Süt, Necdet Hilmi
2017-01-01
Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with atopic dermatitis in Turkish children. Study Design: Case-control study. Methods: The study was conducted on 70 Turkish children with atopic dermatitis aged 0.5-18 years. The clinical severity of atopic dermatitis was evaluated by the severity scoring of atopic dermatitis index. Serum total IgE levels, specific IgE antibodies to inhalant and food allergens were measured in both atopic dermatitis patients and controls, skin prick tests were done on 70 children with atopic dermatitis. Genotyping for TLR2 (R753Q and A-16934T) single nucleotide polymorphisms was performed in both atopic dermatitis patients and controls. Results: Cytosine-cytosine and cytosin-thymine genotype frequencies of the TLR2 R753Q single nucleotide polymorphism in the atopic dermatitis group were determined as being 98.6% and 1.4%, cytosine allele frequency for TLR2 R753Q single nucleotide polymorphism was determined as 99.29% and the thymine allele frequency was 0.71%, thymine-thymine, thymine-adenine, and adenine-adenine genotype frequencies of the TLR2 A-16934T single nucleotide polymorphism were 24.3%, 44.3%, and 31.4%. The thymine allele frequency for the TLR2 A-16934T single nucleotide polymorphism in the atopic dermatitis group was 46.43%, and the adenine allele frequency was 53.57%, respectively. There was not statistically significant difference between the groups for all investigated polymorphisms (p>0.05). For all single nucleotide polymorphisms studied, allelic distribution was analogous among atopic dermatitis patients and controls, and no significant statistical difference was observed. No homozygous carriers of the TLR2 R753Q single nucleotide polymorphism were found in the atopic dermatitis and control groups. Conclusion: The TLR2 (R753Q and A-16934T) single nucleotide polymorphisms are not associated with atopic dermatitis in a group of Turkish patients. PMID:28443596
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Can, Ceren; Yazıcıoğlu, Mehtap; Gürkan, Hakan; Tozkır, Hilmi; Görgülü, Adnan; Süt, Necdet Hilmi
2017-05-05
Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. To evaluate whether single nucleotide polymorphisms in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with atopic dermatitis in Turkish children. Case-control study. The study was conducted on 70 Turkish children with atopic dermatitis aged 0.5-18 years. The clinical severity of atopic dermatitis was evaluated by the severity scoring of atopic dermatitis index. Serum total IgE levels, specific IgE antibodies to inhalant and food allergens were measured in both atopic dermatitis patients and controls, skin prick tests were done on 70 children with atopic dermatitis. Genotyping for TLR2 (R753Q and A-16934T) single nucleotide polymorphisms was performed in both atopic dermatitis patients and controls. Cytosine-cytosine and cytosin-thymine genotype frequencies of the TLR2 R753Q single nucleotide polymorphism in the atopic dermatitis group were determined as being 98.6% and 1.4%, cytosine allele frequency for TLR2 R753Q single nucleotide polymorphism was determined as 99.29% and the thymine allele frequency was 0.71%, thymine-thymine, thymine-adenine, and adenine-adenine genotype frequencies of the TLR2 A-16934T single nucleotide polymorphism were 24.3%, 44.3%, and 31.4%. The thymine allele frequency for the TLR2 A-16934T single nucleotide polymorphism in the atopic dermatitis group was 46.43%, and the adenine allele frequency was 53.57%, respectively. There was not statistically significant difference between the groups for all investigated polymorphisms (p>0.05). For all single nucleotide polymorphisms studied, allelic distribution was analogous among atopic dermatitis patients and controls, and no significant statistical difference was observed. No homozygous carriers of the TLR2 R753Q single nucleotide polymorphism were found in the atopic dermatitis and control groups. The TLR2 (R753Q and A-16934T) single nucleotide polymorphisms are not associated with atopic dermatitis in a group of Turkish patients.
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Sonenblum, Sharon E; Vonk, Teddie E; Janssen, Thomas W; Sprigle, Stephen H
2014-07-01
To investigate the effectiveness and interactions of 2 methods of pressure ulcer prevention, wheelchair cushions and pressure relief maneuvers, on interface pressure (IP) and blood flow of the buttocks. Within-subject repeated measures. Rehabilitation center. Wheelchair users with a spinal cord injury or disorder (N=17). Participants performed 3 forward leans and 2 sideward leans with different degrees of lean while seated on each of 3 different wheelchair cushions. IP measured with a custom sensor and blood flow measured with laser Doppler flowmetry were collected at the ischial tuberosity. Pressure relief maneuvers had a significant main effect on the ischial IP (P<.001); all maneuvers except for the small frontward lean resulted in a significant reduction in IP compared with upright sitting. Blood flow significantly varied across postures (P<.001) with flow during upright sitting and small forward leans being significantly lower than during the full and intermediate leans in both the forward and sideward directions. The results of the study highlight the importance of positioning wheelchair users in a manner that facilitates in-seat movement. Regardless of the cushion being used, the pressure relief maneuvers resulted in very large reductions in IPs and significant increases in buttock blood flow. Only the small frontward lean was shown to be ineffective in reducing pressure or increasing blood flow. Because these pressure relief maneuvers involved postural changes that can occur during functional activities, these pressure relief maneuvers can become a part of volitional pressure relief and functional weight shifts. Therefore, clinical instruction should cover both as a means to impart sitting behaviors that may lead to better tissue health. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
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Sitting Time in Adults 65 Years and Over: Behavior, Knowledge, and Intentions to Change.
Alley, Stephanie; van Uffelen, Jannique G Z; Duncan, Mitch J; De Cocker, Katrien; Schoeppe, Stephanie; Rebar, Amanda L; Vandelanotte, Corneel
2018-04-01
This study examined sitting time, knowledge, and intentions to change sitting time in older adults. An online survey was completed by 494 Australians aged 65+. Average daily sitting was high (9.0 hr). Daily sitting time was the highest during TV (3.3 hr), computer (2.1 hr), and leisure (1.7 hr). A regression analysis demonstrated that women were more knowledgeable about the health risks of sitting compared to men. The percentage of older adults intending to sit less were the highest for TV (24%), leisure (24%), and computer (19%) sitting time. Regression analyses demonstrated that intentions varied by gender (for TV sitting), education (leisure and work sitting), body mass index (computer, leisure, and transport sitting), and physical activity (TV, computer, and leisure sitting). Interventions should target older adults' TV, computer, and leisure time sitting, with a focus on intentions in older males and older adults with low education, those who are active, and those with a normal weight.
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Karakolis, Thomas; Barrett, Jeff; Callaghan, Jack P
2016-10-01
Sedentary office work has been shown to cause low back discomfort and potentially cause injury. Prolonged standing work has been shown to cause discomfort. The implementation of a sit-stand paradigm is hypothesised to mitigate discomfort and prevent injury induced by prolonged exposure to each posture in isolation. This study explored the potential of sit-stand to reduce discomfort and prevent injury, without adversely affecting productivity. Twenty-four participants performed simulated office work in three different conditions: sitting, standing and sit-stand. Variables measured included: perceived discomfort, L4-L5 joint loading and typing/mousing productivity. Working in a sit-stand paradigm was found to have the potential to reduce discomfort when compared to working in a sitting or standing only configuration. Sit-stand was found to be associated with reduced lumbar flexion during sitting compared to sitting only. Increasing lumbar flexion during prolonged sitting is a known injury mechanism. Therefore, sit-stand exhibited a potentially beneficial response of reduced lumbar flexion that could have the potential to prevent injury. Sit-stand had no significant effect on productivity. Practitioner Summary: This study has contributed foundational elements to guide usage recommendations for sit-stand workstations. The sit-stand paradigm can reduce discomfort; however, working in a sit-stand ratio of 15:5 min may not be the most effective ratio. More frequent posture switches may be necessary to realise the full benefit of sit-stand.
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Dry particle generation with a 3-D printed fluidized bed generator
Roesch, Michael; Roesch, Carolin; Cziczo, Daniel J.
2017-06-02
We describe the design and testing of PRIZE (PRinted fluidIZed bed gEnerator), a compact fluidized bed aerosol generator manufactured using stereolithography (SLA) printing. Dispersing small quantities of powdered materials – due to either rarity or expense – is challenging due to a lack of small, low-cost dry aerosol generators. With this as motivation, we designed and built a generator that uses a mineral dust or other dry powder sample mixed with bronze beads that sit atop a porous screen. A particle-free airflow is introduced, dispersing the sample as airborne particles. The total particle number concentrations and size distributions were measured duringmore » different stages of the assembling process to show that the SLA 3-D printed generator did not generate particles until the mineral dust sample was introduced. Furthermore, time-series measurements with Arizona Test Dust (ATD) showed stable total particle number concentrations of 10–150 cm -3, depending on the sample mass, from the sub- to super-micrometer size range. Additional tests with collected soil dust samples are also presented. PRIZE is simple to assemble, easy to clean, inexpensive and deployable for laboratory and field studies that require dry particle generation.« less
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Recognizing sights, smells, and sounds with gnostic fields.
Kanan, Christopher
2013-01-01
Mammals rely on vision, audition, and olfaction to remotely sense stimuli in their environment. Determining how the mammalian brain uses this sensory information to recognize objects has been one of the major goals of psychology and neuroscience. Likewise, researchers in computer vision, machine audition, and machine olfaction have endeavored to discover good algorithms for stimulus classification. Almost 50 years ago, the neuroscientist Jerzy Konorski proposed a theoretical model in his final monograph in which competing sets of "gnostic" neurons sitting atop sensory processing hierarchies enabled stimuli to be robustly categorized, despite variations in their presentation. Much of what Konorski hypothesized has been remarkably accurate, and neurons with gnostic-like properties have been discovered in visual, aural, and olfactory brain regions. Surprisingly, there have not been any attempts to directly transform his theoretical model into a computational one. Here, I describe the first computational implementation of Konorski's theory. The model is not domain specific, and it surpasses the best machine learning algorithms on challenging image, music, and olfactory classification tasks, while also being simpler. My results suggest that criticisms of exemplar-based models of object recognition as being computationally intractable due to limited neural resources are unfounded.
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Recognizing Sights, Smells, and Sounds with Gnostic Fields
Kanan, Christopher
2013-01-01
Mammals rely on vision, audition, and olfaction to remotely sense stimuli in their environment. Determining how the mammalian brain uses this sensory information to recognize objects has been one of the major goals of psychology and neuroscience. Likewise, researchers in computer vision, machine audition, and machine olfaction have endeavored to discover good algorithms for stimulus classification. Almost 50 years ago, the neuroscientist Jerzy Konorski proposed a theoretical model in his final monograph in which competing sets of “gnostic” neurons sitting atop sensory processing hierarchies enabled stimuli to be robustly categorized, despite variations in their presentation. Much of what Konorski hypothesized has been remarkably accurate, and neurons with gnostic-like properties have been discovered in visual, aural, and olfactory brain regions. Surprisingly, there have not been any attempts to directly transform his theoretical model into a computational one. Here, I describe the first computational implementation of Konorski's theory. The model is not domain specific, and it surpasses the best machine learning algorithms on challenging image, music, and olfactory classification tasks, while also being simpler. My results suggest that criticisms of exemplar-based models of object recognition as being computationally intractable due to limited neural resources are unfounded. PMID:23365648
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Dry particle generation with a 3-D printed fluidized bed generator
DOE Office of Scientific and Technical Information (OSTI.GOV)
Roesch, Michael; Roesch, Carolin; Cziczo, Daniel J.
We describe the design and testing of PRIZE (PRinted fluidIZed bed gEnerator), a compact fluidized bed aerosol generator manufactured using stereolithography (SLA) printing. Dispersing small quantities of powdered materials – due to either rarity or expense – is challenging due to a lack of small, low-cost dry aerosol generators. With this as motivation, we designed and built a generator that uses a mineral dust or other dry powder sample mixed with bronze beads that sit atop a porous screen. A particle-free airflow is introduced, dispersing the sample as airborne particles. The total particle number concentrations and size distributions were measured duringmore » different stages of the assembling process to show that the SLA 3-D printed generator did not generate particles until the mineral dust sample was introduced. Furthermore, time-series measurements with Arizona Test Dust (ATD) showed stable total particle number concentrations of 10–150 cm -3, depending on the sample mass, from the sub- to super-micrometer size range. Additional tests with collected soil dust samples are also presented. PRIZE is simple to assemble, easy to clean, inexpensive and deployable for laboratory and field studies that require dry particle generation.« less
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Small-scale lacustrine drifts in Lake Champlain, Vermont
Manley, Patricia L.; Manley, T.O.; Hayo, Kathryn; Cronin, Thomas
2012-01-01
High resolution CHIRP (Compressed High Intensity Radar Pulse) seismic profiles reveal the presence of two lacustrine sediment drifts located in Lake Champlain's Juniper Deep. Both drifts are positive features composed of highly laminated sediments. Drift B sits on a basement high while Drift A is built on a trough-filling acoustically-transparent sediment unit inferred to be a mass-transport event. These drifts are oriented approximately north–south and are parallel to a steep ridge along the eastern shore of the basin. Drift A, located at the bottom of a structural trough, is classified as a confined, elongate drift that transitions northward to become a system of upslope asymmetric mudwaves. Drift B is perched atop a structural high to the west of Drift A and is classified as a detached elongate drift. Bottom current depositional control was investigated using Acoustic Doppler Current Profilers (ADCPs) located across Drift A. Sediment cores were taken at the crest and at the edges of the Drift A and were dated. Drift source, deposition, and evolution show that these drifts are formed by a water column shear with the highest deposition occurring along its crest and western flank and began developing circa 8700–8800 year BP.
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NASA Astrophysics Data System (ADS)
Zannotti, Marco; Giovannetti, Rita; Minofar, Babak; Řeha, David; Plačková, Lydie; D'Amato, Chiara A.; Rommozzi, Elena; Dudko, Hanna V.; Kari, Nuerguli; Minicucci, Marco
2018-03-01
The effect of pH change on 5,10,15,20-Tetrakis(4-hydroxyphenyl)-21H,23H-porphine (THPP) with its aggregation as function of water-ethanol mixture was studied with UV-vis, fluorescence, Raman and computational analysis. In neutral pH, THPP was present as free-base and, increasing the water amount, aggregation occurred with the formation of H- and J-aggregates. The aggregation constant and the concentration of dimers were calculated, other information about the dimer aggregation were evaluated by computational study. In acidic pH, by the insertions of two hydrogens in the porphyrin rings, the porphyrin changed its geometry with a ring deformation confirmed by red-shifted spectrum and quenching in fluorescence; at this low pH, increasing the water amount, the acidic form (THPPH2)2 + resulted more stable due to a polar environment with stronger interaction by hydrogen bonding. In basic pH, reached by NH4OH, THPP porphyrin was able to react with alkali metals in order to form sitting-atop complex (M2THPP) confirmed by the typical absorption spectrum of metallo-porphyrin, Raman spectroscopy and by computational analysis.
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2001-06-21
KENNEDY SPACE CENTER, Fla. -- Atop the mobile launcher platform, Space Shuttle Atlantis, with its orange external tank and white solid rocket boosters, sits on Launch Pad 39B after rollout from the Vehicle Assembly Building. Seen on either side of the orbiter’s tail are the tail service masts. They support the fluid, gas and electrical requirements of the orbiter’s liquid oxygen and liquid hydrogen aft umbilicals. The Shuttle is targeted for launch no earlier than July 12 on mission STS-104, the 10th flight to the International Space Station. The payload on the 11-day mission is the Joint Airlock Module, which will allow astronauts and cosmonauts in residence on the Station to perform future spacewalks without the presence of a Space Shuttle. The module, which comprises a crew lock and an equipment lock, will be connected to the starboard (right) side of Node 1 Unity. Atlantis will also carry oxygen and nitrogen storage tanks, vital to operation of the Joint Airlock, on a Spacelab Logistics Double Pallet in the payload bay. The tanks, to be installed on the perimeter of the Joint Module during the mission’s spacewalks, will support future spacewalk operations and experiments plus augment the resupply system for the Station’s Service Module
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Space Shuttle Atlantis is on Launch Pad 39B
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- Atop the mobile launcher platform, Space Shuttle Atlantis, with its orange external tank and white solid rocket boosters, sits on Launch Pad 39B after rollout from the Vehicle Assembly Building. Seen on either side of the orbiters tail are the tail service masts. They support the fluid, gas and electrical requirements of the orbiters liquid oxygen and liquid hydrogen aft umbilicals. The Shuttle is targeted for launch no earlier than July 12 on mission STS-104, the 10th flight to the International Space Station. The payload on the 11- day mission is the Joint Airlock Module, which will allow astronauts and cosmonauts in residence on the Station to perform future spacewalks without the presence of a Space Shuttle. The module, which comprises a crew lock and an equipment lock, will be connected to the starboard (right) side of Node 1 Unity. Atlantis will also carry oxygen and nitrogen storage tanks, vital to operation of the Joint Airlock, on a Spacelab Logistics Double Pallet in the payload bay. The tanks, to be installed on the perimeter of the Joint Module during the missions spacewalks, will support future spacewalk operations and experiments plus augment the resupply system for the Stations Service Module.
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Ryde, Gemma Cathrine; Brown, Helen Elizabeth; Gilson, Nicholas David; Brown, Wendy J
2014-09-01
Prolonged occupational sitting is related to poor health outcomes. Detailed data on sitting time at desks are required to understand and effectively influence occupational sitting habits. Full-time office employees were recruited (n = 105; mean age 40.9 ± 11.5 years; BMI 26.1 ± 3.9, 65% women). Sitting at the desk and in other work contexts was measured using a sitting pad and ActivPAL for an entire working week. Employees used a diary to record work hours. Time spent at work, sitting at work and at the desk; number of sit to stand transitions at the desk; and number of bouts of continuous sitting at the desk < 20 and > 60 minutes, were calculated. Average time spent at work was 8.7 ± 0.8 hours/day with 67% spent sitting at the desk (5.8 ± 1.2 hours/day), and 4% in other workplace settings. On average, employees got up from their desks 3 times/hour (29 ± 13/day). Sitting for more than 60 consecutive minutes occurred infrequently (0.69 ± 0.62 times/day), with most sit to stands (80%; 23 ± 14) occurring before 20 minutes of continual sitting. The findings provide highly detailed insights into desk-based sitting habits, highlighting large proportions of time spent sitting at desks, but with frequent interruptions.
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Kloster, Stine; Danquah, Ida Høgstedt; Holtermann, Andreas; Aadahl, Mette; Tolstrup, Janne Schurmann
2017-01-01
Harmful health effects associated with sedentary behavior may be attenuated by breaking up long periods of sitting by standing or walking. However, studies assess interruptions in sitting time differently, making comparisons between studies difficult. It has not previously been described how the definition of minimum break duration affects sitting outcomes. Therefore, the aim was to address how definitions of break length affect total sitting time, number of sit-to-stand transitions, prolonged sitting periods and time accumulated in prolonged sitting periods among office workers. Data were collected from 317 office workers. Thigh position was assessed with an ActiGraph GT3X+ fixed on the right thigh. Data were exported with varying bout length of breaks. Afterward, sitting outcomes were calculated for the respective break lengths. Absolute numbers of sit-to-stand transitions decreased, and number of prolonged sitting periods and total time accumulated in prolonged sitting periods increased, with increasing minimum break length. Total sitting time was not influenced by varying break length. The definition of minimum break length influenced the sitting outcomes with the exception of total sitting time. A standard definition of break length is needed for comparison and interpretation of studies in the evolving research field of sedentary behavior.
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Early-life risk factors for occurrence of atopic dermatitis during the first year.
Sugiyama, Mikio; Arakawa, Hirokazu; Ozawa, Kiyoshi; Mizuno, Takahisa; Mochizuki, Hiroyuki; Tokuyama, Kenichi; Morikawa, Akihiro
2007-03-01
In a prospective birth cohort study, we sought to identify perinatal predictors of the occurrence of atopic dermatitis in the first year of life. Associations of family history, infection during pregnancy, cord blood cytokine concentrations, and skin function parameters with atopic dermatitis were analyzed. Stratum corneum hydration was measured with an impedance meter until 5 days after delivery and again at 1 month. Complete data were obtained for 213 infants, including 27 diagnosed by a physician as having atopic dermatitis during their first year and 26 diagnosed as having infantile eczema during their first month. The risk of atopic dermatitis during the first year of life was related to maternal atopic dermatitis, lower concentrations of macrophage inflammatory protein-1beta in cord blood, and greater skin moisture in the surface and stratum corneum of the forehead and cheek at 1 month of age but not to viral or bacterial infection during pregnancy or breastfeeding. Paternal hay fever was associated negatively with the development of atopic dermatitis. High concentrations of interleukin-5, interleukin-17, and macrophage chemotactic protein-1 and only surface moisture in the cheek were associated with greater risk of infantile eczema in the first month. The association of atopic dermatitis in infancy with reduced neonatal macrophage inflammatory protein-1beta levels suggests a link with immature immune responses at birth. Stratum corneum barrier disruption in atopic dermatitis may involve impairment of cutaneous adaptation to extrauterine life. The majority of risk factors had different effects on infant eczema and atopic dermatitis, indicating different causes.
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Foolad, N; Armstrong, A W
2014-06-01
The purpose of this review was to identify whether supplementation with prebiotics and/or probiotics help prevent the development or reduce the severity of atopic dermatitis in children less than three years of age. Since 1997, immunostimulatory supplements, such as prebiotics and probiotics, have been investigated. Various supplementations include probiotics (single strain or mix), probiotics with formula, probiotics mix with prebiotics, and prebiotics. In this narrative review, we examined 13 key articles on prebiotics and/or probiotics, and their effects on infant atopic dermatitis. Among the selected studies, a total of 3,023 participants received supplements or placebo. Eight out of the 13 (61.5%) studies reported a significant effect on the prevention of atopic dermatitis after supplementation with probiotics and/or prebiotics. Five out of the 13 (38.5%) studies indicated significant reduction in the severity of atopic dermatitis after supplementation. Based on the available studies, supplementation with certain probiotics (Lactobacillus rhamnosus GG) appears to be an effective approach for the prevention and reduction in severity of atopic dermatitis. A mix of specific probiotic strains prevented atopic dermatitis among infants. Based on studies with prebiotics, there was a long-term reduction in the incidence of atopic dermatitis. Supplementation with prebiotics and probiotics appears useful for the reduction in the severity of atopic dermatitis. Additional interventional studies exploring prebiotics and probiotics are imperative before recommendations can be made.
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Stressors in Atopic Dermatitis.
Barilla, Steven; Felix, Kayla; Jorizzo, Joseph L
2017-01-01
As with other inflammatory skin disorders, atopic dermatitis has a tendency to cause stress and also be exacerbated by it. Patients with atopic dermatitis have several disease-associated stressors, some of which include physical discomfort due to itching and altered appearance due to flare-ups. These stressors have been shown to effect patients psychosocially by altering sleep patterns, decreasing self-esteem and interfering with interpersonal relationships. In combination with its direct effect on patients, atopic dermatitis also causes stress for parents and caregivers. Studies suggest that atopic dermatitis is strongly correlated with co-sleeping habits, which can negatively impact the health and mood of parents or caregivers. It has also been reported to interfere with the formation of a strong mother-child relationship. In order to optimize treatment for patients with atopic dermatitis, it is important to note the impact that it has on quality of life. By implementing patient counseling, sleep-targeted therapies, and the use of quality of life (QoL) indices, atopic dermatitis patients and caregivers have the potential to experience greater satisfaction with treatment.
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The Association Between Bathing Habits and Severity of Atopic Dermatitis in Children.
Koutroulis, Ioannis; Pyle, Tia; Kopylov, David; Little, Anthony; Gaughan, John; Kratimenos, Panagiotis
2016-02-01
Atopic dermatitis is an inflammatory skin disease that frequently affects children. The current recommendations on management using lifestyle modification are highly variable, leading to confusion and uncertainty among patients. To determine current bathing behaviors and the subsequent impact on disease severity. This was an observational cross-sectional study conducted at an urban pediatric emergency department. Parents were asked to fill out a questionnaire concerning the patient's bathing habits. The results were correlated with the atopic dermatitis severity determined by the SCORAD (SCORing Atopic Dermatitis) tool. No difference between variables was found to be significant for bathing frequency, time spent bathing, or use of moisturizers. Multivariate analysis showed that atopic dermatitis severity increased with age greater than 2 years (P = .0004) and with greater bathing duration (P = .001). Atopic dermatitis severity may be associated with a longer duration of bathing. The frequency of bathing does not appear to affect atopic dermatitis severity. © The Author(s) 2015.
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Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents.
Doñate, F.; Artigues, A.; Iriarte, A.; Martinez-Carrion, M.
1998-01-01
GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents. PMID:10082379
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Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents.
Doñate, F; Artigues, A; Iriarte, A; Martinez-Carrion, M
1998-08-01
GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents.
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Fornander, Louise H; Frykholm, Karolin; Reymer, Anna; Renodon-Cornière, Axelle; Takahashi, Masayuki; Nordén, Bengt
2012-06-01
Human RAD51 protein (HsRad51) catalyses the DNA strand exchange reaction for homologous recombination. To clarify the molecular mechanism of the reaction in vitro being more effective in the presence of Ca(2+) than of Mg(2+), we have investigated the effect of these ions on the structure of HsRad51 filament complexes with single- and double-stranded DNA, the reaction intermediates. Flow linear dichroism spectroscopy shows that the two ionic conditions induce significantly different structures in the HsRad51/single-stranded DNA complex, while the HsRad51/double-stranded DNA complex does not demonstrate this ionic dependence. In the HsRad51/single-stranded DNA filament, the primary intermediate of the strand exchange reaction, ATP/Ca(2+) induces an ordered conformation of DNA, with preferentially perpendicular orientation of nucleobases relative to the filament axis, while the presence of ATP/Mg(2+), ADP/Mg(2+) or ADP/Ca(2+) does not. A high strand exchange activity is observed for the filament formed with ATP/Ca(2+), whereas the other filaments exhibit lower activity. Molecular modelling suggests that the structural variation is caused by the divalent cation interfering with the L2 loop close to the DNA-binding site. It is proposed that the larger Ca(2+) stabilizes the loop conformation and thereby the protein-DNA interaction. A tight binding of DNA, with bases perpendicularly oriented, could facilitate strand exchange.
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Smart glass based on electrochromic polymers
NASA Astrophysics Data System (ADS)
Xu, Chunye; Kong, Xiangxing; Liu, Lu; Su, Fengyu; Kim, Sooyeun; Taya, Minoru
2006-03-01
Five-layer-structured electrochromic glass (window), containing a transparent conductive layer, an electrochromic layer, an ionic conductive layer, an ionic storage layer and a second conductive transparent layer, was fabricated. The electrochromic glass adopts the conjugated polymer, poly[3,3-dimethyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine] (PProDOT-Me2), as a blue electrochromic active layer, vanadium pentaoxide film as an ion storage layer and polymer gel electrolyte as the ionic transport layer. Dimension of smart glass up to 12 x 20 inch was developed. UV curable sealant was applied for the sealing devices. Color changing or switching speed of 12 x 20 inch smart glass from dark state to the transparent state (or vise versa) is less than 15 seconds under applied 1.5 voltages. Besides the long open circuit memory (the colored state or transparent state remains the same state after the power is off), the smart window can be adjusted easily into the intermediate state between the dark state and the transparent state by just simply turn the power on or off. No space consuming or dirt collecting shades, curtains or blinds are needed. The applications of the smart window, e.g. in the aircrafts, automobiles and architectures were discussed as well.
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Ionomers for Ion-Conducting Energy Materials
NASA Astrophysics Data System (ADS)
Colby, Ralph
For ionic actuators and battery separators, it is vital to utilize single-ion conducting ionomers that avoid the detrimental polarization of other ions. Single-ion conducting ionomers are synthesized based on DFT calculations, with low glass transition temperatures (facile dynamics) to prepare ion-conducting membranes for battery separators that conduct Li+ or Na+. Characterization by X-ray scattering, dielectric spectroscopy, FTIR, NMR and linear viscoelasticity collectively develop a coherent picture of ionic aggregation and both counterion and polymer dynamics. 7Li NMR diffusion measurements find that diffusion is faster than expected by conductivity using the Nernst-Einstein equation, which means that the majority of Li diffusion occurs by ion pairs moving with the polymer segmental motion. Segmental motion only contributes to ionic conduction in the rare event that one of these ion pairs has an extra Li (a positive triple ion). This leads us to a new metric for ion-conducting soft materials, the product of the cation number density p0 and their diffusion coefficient D; p0D is the diffusive flux of lithium ions. This new metric has a maximum at intermediate ion content that corresponds to the overlap of ion pair polarizability volumes. At higher ion contents, the ion pairs interact strongly and form larger aggregation states that retard segmental motion of both mobile ion pairs and triple ions.
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Mart'ianov, Andrey A; Dzantiev, Boris B; Zherdev, Anatoly V; Eremin, Sergei A; Cespedes, Raquel; Petrovic, Mira; Barcelo, Damia
2005-01-30
Immunoenzyme assay (ELISA) is proposed and characterized for determination of alkylphenol ethoxylates, a primary class of manufactured non-ionic surfactants. The assay is based on the obtained polyclonal antibodies against nonylphenol (NP), the main stable intermediate of the decomposition of nonylphenol ethoxylates. A mixture of non-modified branched isomers of NP was applied as hapten coupled to protein carriers by Mannich reaction with the use of formaldehyde. The proposed ELISA format is based on immobilized NP-(soybean trypsin inhibitor) conjugate as a competitor of antigen molecules contained in the tested sample for binding with specific antibodies indirectly labeled via an anti-species immunoperoxidase conjugate. The developed ELISA allows to reveal NP with the limit of detection about 10ngml(-1) and NP-related compounds such as octylphenol, alkylphenoletoxylates, alkylphenolcarboxylates and their halogenated derivatives. The ELISA was applied for assaying polluted water samples, namely influents and effluents from different wastewater treatment plants (WWTP) and tap water. ELISA and chromatographic data demonstrate good correlation (r = 0.94), while ELISA gives higher values. Due to endocrine disrupting and other toxic activities of some metabolites of alkylphenolic non-ionic surfactants, the developed assay may be effectively used in ecological monitoring and sanitary control.
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Mena, Ismael F; Cotillas, Salvador; Díaz, Elena; Sáez, Cristina; Mohedano, Ángel F; Rodrigo, Manuel A
2017-12-06
In this work, sono- and photoelectrolysis of synthetic wastewaters polluted with the ionic liquids 1-Butyl-3-methylimidazolium acetate (BmimAc) and chloride (BmimCl) were investigated with diamond anodes. The results were compared to those attained by enhancing bare electrolysis with irradiation by UV light or with the application of high-frequency ultrasound (US). Despite its complex heterocyclic structure, the Bmim + cation was successfully depleted with the three technologies that were tested and was mainly transformed into four different organic intermediates, an inorganic nitrogen species and carbon dioxide. Regardless of the technology that was evaluated, removal of the heterocyclic ring is much less efficient (and much slower) than oxidation of the counter ion. In turn, the counter ion influences the rate of removal of the ionic liquid cation. Thus, the electrolysis and photoelectrolysis of BmimAc are much less efficient than sonoelectrolysis, but their differences become much less important in the case of BmimCl. In this later case, the most efficient technology is photoelectrolysis. This result is directly related to the generation of free radicals in the solution by irradiation of the electrochemical system with UV light, which contributes significantly to the removal of Bmim + . Copyright © 2017 Elsevier B.V. All rights reserved.
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What Do Older People Do When Sitting and Why? Implications for Decreasing Sedentary Behavior.
Palmer, Victoria J; Gray, Cindy M; Fitzsimons, Claire F; Mutrie, Nanette; Wyke, Sally; Deary, Ian J; Der, Geoff; Chastin, Sebastien F M; Skelton, Dawn A
2018-05-15
Sitting less can reduce older adults' risk of ill health and disability. Effective sedentary behavior interventions require greater understanding of what older adults do when sitting (and not sitting), and why. This study compares the types, context, and role of sitting activities in the daily lives of older men and women who sit more or less than average. Semistructured interviews with 44 older men and women of different ages, socioeconomic status, and objectively measured sedentary behavior were analyzed using social practice theory to explore the multifactorial, inter-relational influences on their sedentary behavior. Thematic frameworks facilitated between-group comparisons. Older adults described many different leisure time, household, transport, and occupational sitting and non-sitting activities. Leisure-time sitting in the home (e.g., watching TV) was most common, but many non-sitting activities, including "pottering" doing household chores, also took place at home. Other people and access to leisure facilities were associated with lower sedentary behavior. The distinction between being busy/not busy was more important to most participants than sitting/not sitting, and informed their judgments about high-value "purposeful" (social, cognitively active, restorative) sitting and low-value "passive" sitting. Declining physical function contributed to temporal sitting patterns that did not vary much from day-to-day. Sitting is associated with cognitive, social, and/or restorative benefits, embedded within older adults' daily routines, and therefore difficult to change. Useful strategies include supporting older adults to engage with other people and local facilities outside the home, and break up periods of passive sitting at home.
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Therapeutic strategies for allergic diseases
NASA Astrophysics Data System (ADS)
Barnes, Peter J.
1999-11-01
Many drugs are now in development for the treatment of atopic diseases, including asthma, allergic rhinitis and atopic dermatitis. These treatments are based on improvements in existing therapies or on a better understanding of the cellular and molecular mechanisms involved in atopic diseases. Although most attention has been focused on asthma, treatments that inhibit the atopic disease process would have application to all atopic diseases, as they often coincide. Most of the many new therapies in development are aimed at inhibiting components of the allergic inflammatory response, but in the future there are real possibilities for the development of preventative and even curative treatments.
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Markova, M D
2001-01-01
Nuclear matrix and intermediate filaments (NM-IF) can be isolated by sequential treatment with non-ionic detergent, high salt. and nuclease. Extracted cells are easily observed by unembedded whole-mount transmission electron microscopy. Different somatic cell types have been subjected to this procedure and retained their essential architecture. To our knowledge, this work describes the first application of NM-IF extraction to sperm. After chemical dissection the general appearance of mouse sperm cells was preserved, except for head-from-neck separation in some cases. The cell membrane, acrosome and mitochondria were not present. The nucleus showed no apparent changes and revealed no details excepting pore complexes in the posterior part. Tissue-specific cytoskeletal elements (perforatorium, postacrosomal sheath, capitulum, segmented columns, outer dense fibers, submitochondrial reticulum, annulus, and fibrous sheath) were retained, which permitted a parallel between them and intermediate filaments of somatic cells. Tail microtubules were also relatively well preserved, showing high intrinsic stability. Cell structures could be observed well, with some details in the tail even better visible than in ultrathin sections. Observation of mouse sperm whole mounts after NM-IF extraction not only revealed intermediate filament-like properties of their cytoskeletal elements but also offered an additional viewpoint to sperm ultrastructure.
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Tripathi, Pankaj; Anuradha, S; Ghosal, Gargi; Muniyappa, K
2006-12-08
Saccharomyces cerevisiae HOP1, which encodes a component of synaptonemal complex (SC), plays an important role in both gene conversion and crossing over between homologs, as well as enforces meiotic recombination checkpoint control over the progression of recombination intermediates. In hop1Delta mutants, meiosis-specific double-strand breaks (DSBs) are reduced to 10% of the wild-type level, and at aberrantly late times, these DSBs are processed into inter-sister recombination intermediates. However, the underlying mechanism by which Hop1 protein regulates these nuclear events remains obscure. Here we show that Hop1 protein interacts selectively with the Holliday junction, changes its global conformation and blocks the dissolution of the junction by a RecQ helicase. The Holliday junction-Hop1 protein complexes are significantly more stable at higher ionic strengths and molar excess of unlabeled competitor DNA than complexes containing other recombination intermediates. Structural analysis of the Holliday junction using 2-aminopurine fluorescence emission, DNase I footprinting and KMnO4 probing provide compelling evidence that Hop1 protein binding induces significant distortion at the center of the Holliday junction. We propose that Hop1 protein might coordinate the physical monitoring of meiotic recombination intermediates with the process of branch migration of Holliday junction.
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Arga, M; Bakirtas, A; Topal, E; Turktas, I
2015-04-01
The interrelation between airway inflammation, bronchial hyperresponsiveness (BHR) and atopy remains controversial. The aim of this study was to document whether exhaled nitric oxide (eNO) may be used as a surrogate marker that predicts BHR to adenosine 5'-monophosphate (AMP) in steroid-naive school children with asthma. This study was a retrospective analysis of steroid-naive school age children with atopic and non-atopic asthma. All patients whose eNO levels had been measured and who had been challenged with both methacholine (MCH) and AMP were included. Receiver operation characteristic analysis was performed, in both the atopic and the non-atopic groups, to evaluate the ability of eNO to detect the BHR to AMP. One hundred and sixteen patients, sixty-nine (59.5%) of whom had been atopic, were included in the analysis. In the atopic group, eNO values were significantly higher in patients with BHR to AMP compared to those without BHR to AMP (51.9 ± 16.9 p.p.b. vs. 33.7 ± 16.4 p.p.b.; P < 0.001), whereas in the non-atopic group, the differences were not statistically significant (29.7 ± 16.9 p.p.b. vs. 22.6 ± 8.1 p.p.b.; P = 0.152). In the atopic group, eNO levels (R(2) : 0.401; β: 0.092; 95% CI: 1.19-14.42; OR: 7.12; P = 0.008) were found to be the only independent factor for BHR to AMP, whereas none of the parameters predicted BHR to AMP in the non-atopic group. The best cut-off value of eNO that significantly predicts BHR to AMP was 33.3 p.p.b. in the atopic group (P < 0.001), whereas a significant cut-off value for eNO that predicts BHR to AMP was not determined in the non-atopic group (P = 0.142). An eNO ≤ 17.4 p.p.b. has 100% negative predictive values and 100% sensitivity and 60.47% PPV for prediction of BHR to AMP in the atopic group. Exhaled NO may be used to predict BHR to AMP in atopic but not in non-atopic steroid-naïve asthmatic children. © 2014 John Wiley & Sons Ltd.
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Holmlund, U; Bengtsson, A; Nilsson, C; Kusoffsky, E; Lilja, G; Scheynius, A; Sverremark-Ekström, E
2003-11-01
The CD30 molecule has been linked to Th2 responses. Furthermore, elevated levels of the soluble form of CD30 (sCD30) in blood as well as of the expression of CD30 on the plasma membrane of T cells are associated with atopic disease. To assess the potential usefulness of sCD30 levels as a prognostic indicator of and/or diagnostic marker for the development of atopic disease in children. sCD30 levels in cord blood and peripheral blood from 36 2-year-old (10 atopic and 26 non-atopic) and 74 7-year-old (35 atopic and 39 non-atopic) children were determined employing an ELISA procedure. Atopy was diagnosed on the basis of clinical evaluation in combination with a positive skin prick test. No significant correlation between sCD30 levels in cord blood and the development of atopic disease at 2 or 7 years of age was observed. At 7 years of age, the circulating sCD30 levels in children with atopic disease (median 41 U/mL, range 6-503 U/mL) did not differ from the corresponding values for non-atopic subjects (median 41 U/mL, range 8-402 U/mL). The same was true for children at 2 years of age. Furthermore, the sCD30 levels of children who had developed atopic eczema/dermatitis syndrome by the age of 7 years (median 49 U/mL, range 14-503 U/mL) were not significantly elevated in comparison with those of the non-atopic children. Finally, neither sCD30 levels in cord blood nor peripheral blood at 2 or 7 years of age could be linked to a family history of atopy. These findings indicate that the sCD30 concentration in cord blood is not a reliable prognostic indicator of, nor a useful diagnostic marker for, atopic disease in children up to 7 years of age. If such correlations do exist, they might be masked by age-dependent variations in the circulating levels of sCD30, which may reflect individual differences in the maturation of children's immunological responses.
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Wallmann-Sperlich, Birgit; Bucksch, Jens; Schneider, Sven; Froboese, Ingo
2014-12-11
Sitting time is ubiquitous for most adults in developed countries and is most prevalent in three domains: in the workplace, during transport and during leisure time. The correlates of prolonged sitting time in workplace settings are not well understood. Therefore, the aim of this study was to examine the gender-specific associations between the socio-demographic, behavioural and cognitive correlates of work-related sitting time. A cross-sectional sample of working German adults (n = 1515; 747 men; 43.5 ± 11.0 years) completed questionnaires regarding domain-specific sitting times and physical activity (PA) and answered statements concerning beliefs about sitting. To identify gender-specific correlates of work-related sitting time, we used a series of linear regressions. The overall median was 2 hours of work-related sitting time/day. Regression analyses showed for men (β = -.43) and for women (β = -.32) that work-related PA was negatively associated with work-related sitting time, but leisure-related PA was not a significant correlate. For women only, transport-related PA (β = -.07) was a negative correlate of work-related sitting time, suggesting increased sitting times during work with decreased PA in transport. Education and income levels were positively associated, and in women only, age (β = -.14) had a negative correlation with work-related sitting time. For both genders, TV-related sitting time was negatively associated with work-related sitting time. The only association with cognitive correlates was found in men for the belief 'Sitting for long periods does not matter to me' (β = .10) expressing a more positive attitude towards sitting with increasing sitting durations. The present findings show that in particular, higher educated men and women as well as young women are high-risk groups to target for reducing prolonged work-related sitting time. In addition, our findings propose considering increasing transport-related PA, especially in women, as well as promoting recreation-related PA in conjunction with efforts to reduce long work-related sitting times.
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Kwon, Jeoung A.; Park, Eun-Cheol; Lee, Minjee; Yoo, Ki-Bong; Park, Sohee
2013-01-01
This study investigated the relationship between level of stress in middle and high school students aged 12–18 and risk of atopic dermatitis. Data from the Sixth Korea Youth Risk Behavior Web-based Survey (KYRBWS-VI), a cross-sectional study among 74,980 students in 800 middle schools and high schools with a response rate of 97.7%, were analyzed. Ordinal logistic regression analyses were conducted to determine the relationship between stress and atopic dermatitis with severity. A total of 5,550 boys and 6,964 girls reported having been diagnosed with atopic dermatitis. Younger students were more likely to have atopic dermatitis. Interestingly, the educational level of parents was found to be associated with having atopic dermatitis and having more severe condition. In particular, girls with mothers with at least college education had a 41% higher risk of having atopic dermatitis and severe atopic condition (odds ratio (OR)) = 1.41, 95% CI, 1.22–1.63; P<0.0001) compared with those with mothers who had attended middle school at most. Similar trend was shown among both boys and girls for their father's education level. The stress level was found to be significantly associated with the risk of atopic dermatitis. Compared to boys with who reported “no stress”, boys with “very high” stress had 46% higher the risk of having more severe atopic dermatitis (OR = 1.46, 95% CI, 1.20–1.78; P<0.0001), 44% higher (OR = 1.44, 95% CI, 1.19–1.73; P<0.0001) with “high” stress, and 21% higher (OR = 1.21, 95% CI, 1.00–1.45; P = 0.05) with “moderate” stress. In contrast, we found no statistically significant relationship between stress and atopic dermatitis in girls. This study suggests that stress and parents' education level were associated with atopic dermatitis. Specifically, degree of stress is positively correlated with likelihood of being diagnosed with this condition and increasing the severity. PMID:23940513
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Perceived body discomfort and trunk muscle activity in three prolonged sitting postures
Waongenngarm, Pooriput; Rajaratnam, Bala S.; Janwantanakul, Prawit
2015-01-01
[Purpose] This study aimed to investigate the perceived discomfort and trunk muscle activity in three different 1-hour sitting postures. [Subjects] A repeated-measures design study was conducted on 10 healthy subjects. [Methods] Each subject sat for an hour in three sitting postures (i.e., upright, slumped, and forward leaning sitting postures). Subjects rated perceived body discomfort using Borg’s CR-10 scale at the beginning and after 1 hour sitting. The electromyographic activity of the trunk muscle activity was recorded during the 1-hour period of sitting. [Results] The forward leaning sitting posture led to higher Borg scores in the low back than those in the upright (p = 0.002) and slumped sitting postures (p < 0.001). The forward leaning posture was significantly associated with increased iliocostalis lumborum pars thoracis (ICL) and superficial lumbar multifidus (MF) muscle activity compared with the upright and slumped sitting postures. The upright sitting posture was significantly associated with increased internal oblique (IO)/transversus abdominis (TrA) and ICL muscle activity compared with the slumped sitting posture. [Conclusion] The sitting posture with the highest low back discomfort after prolonged sitting was the forward leaning posture. Sitting in an upright posture is recommended because it increases IO/TrA muscle activation and induces only relatively moderate ICL and MF muscle activation. PMID:26311951
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Increased risk of asthma in overweight children born large for gestational age.
Pinto, L A; Guerra, S; Anto, J M; Postma, D; Koppelman, G H; de Jongste, J C; Gehring, U; Smit, H A; Wijga, A H
2017-08-01
Being born large for gestational age (LGA) is a marker of increased growth velocity in fetal life and a risk factor for childhood overweight. Both being born LGA and childhood overweight may influence the development of asthma, although the role of overweight in the association between LGA and childhood asthma is unclear. Importantly, recent studies have suggested that the association between overweight and asthma may be related to non-allergic pathways. If this also applies to the association between LGA and asthma, the association between being born LGA and asthma may be different for atopic and non-atopic children. We investigated the association of being LGA with the prevalence of asthma at age 8 in atopic and non-atopic children and the role of overweight in this association. Complete data on asthma, anthropometry and atopy at age of 8 years, and potential confounders were available for 1608 participants of the PIAMA birth cohort. Odds ratios for the association between LGA and asthma in atopic and non-atopic children were estimated by logistic regression analysis adjusting for potential confounders. Overweight was assessed as a potential modifier of the association between LGA and asthma. Being born LGA was not significantly associated with asthma at age of 8 in atopic and non-atopic children. However, overweight at age of 8 years modified the association between asthma at age of 8 and LGA. In non-atopic children, children who were born LGA and were overweight at age of 8 years had a significantly increased odds of asthma compared to non-LGA, non-overweight children (adj OR 7.04; 95% CI 2.2-24). We observed that non-atopic children born LGA, who were overweight by 8 years have an increased risk of asthma. If confirmed, these findings suggest that non-atopic children born LGA may be identified early in life as a high-risk group for asthma. © 2017 John Wiley & Sons Ltd.
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Breastfeeding and atopic eczema in Japanese infants: The Osaka Maternal and Child Health Study.
Miyake, Yoshihiro; Tanaka, Keiko; Sasaki, Satoshi; Kiyohara, Chikako; Ohya, Yukihiro; Fukushima, Wakaba; Yokoyama, Tetsuji; Hirota, Yoshio
2009-05-01
Epidemiological studies associated with breastfeeding have provided conflicting results about whether it is preventive or a risk factor for atopic eczema in children. The current prospective study investigated the relationship between breastfeeding and the risk of atopic eczema in Japan. A birth cohort of 763 infants was followed. The first survey during pregnancy and the second survey between 2 and 9 months postpartum collected information on potential confounding factors and atopic eczema status. Data on breastfeeding and symptoms of atopic eczema were obtained from questionnaires in the third survey from 16 to 24 months postpartum. The following variables were a priori selected as potential confounders: maternal age, maternal and paternal history of asthma, atopic eczema, and allergic rhinitis, indoor domestic pets (cats, dogs, birds, or hamsters), family income, maternal and paternal education, maternal smoking during pregnancy, baby's sex, baby's birth weight, baby's older siblings, household smoking in the same room as the infant, and time of delivery before the third survey. In the third survey, 142 infants (18.6%) were revealed to have developed atopic eczema based on criteria of the International Study of Asthma and Allergies in Childhood. In an overall analysis, neither exclusive nor partial breastfeeding was significantly related to the risk of atopic eczema. After excluding 64 infants identified with suspected atopic eczema in the second survey, both exclusive breastfeeding for 4 months or more and partial breastfeeding for 6 months or more were independently associated with an increased risk of atopic eczema only among infants with no parental history of allergic disorders [multivariate odds ratios were 2.41 (95% confidence interval, 1.10-5.55) and 3.39 (95% confidence interval, 1.20-12.36), respectively]. The authors found that, overall, neither exclusive nor partial breastfeeding had a strong impact on the risk of atopic eczema. However, a parental allergic history may affect the risk.
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NASA Astrophysics Data System (ADS)
Comlekoglu, T.; Weinberg, S. H.
2017-09-01
Cardiac memory is the dependence of electrical activity on the prior history of one or more system state variables, including transmembrane potential (Vm), ionic current gating, and ion concentrations. While prior work has represented memory either phenomenologically or with biophysical detail, in this study, we consider an intermediate approach of a minimal three-variable cardiomyocyte model, modified with fractional-order dynamics, i.e., a differential equation of order between 0 and 1, to account for history-dependence. Memory is represented via both capacitive memory, due to fractional-order Vm dynamics, that arises due to non-ideal behavior of membrane capacitance; and ionic current gating memory, due to fractional-order gating variable dynamics, that arises due to gating history-dependence. We perform simulations for varying Vm and gating variable fractional-orders and pacing cycle length and measure action potential duration (APD) and incidence of alternans, loss of capture, and spontaneous activity. In the absence of ionic current gating memory, we find that capacitive memory, i.e., decreased Vm fractional-order, typically shortens APD, suppresses alternans, and decreases the minimum cycle length (MCL) for loss of capture. However, in the presence of ionic current gating memory, capacitive memory can prolong APD, promote alternans, and increase MCL. Further, we find that reduced Vm fractional order (typically less than 0.75) can drive phase 4 depolarizations that promote spontaneous activity. Collectively, our results demonstrate that memory reproduced by a fractional-order model can play a role in alternans formation and pacemaking, and in general, can greatly increase the range of electrophysiological characteristics exhibited by a minimal model.
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Effect of electrolytes on proteins physisorption on ordered mesoporous silica materials.
Salis, Andrea; Medda, Luca; Cugia, Francesca; Monduzzi, Maura
2016-01-01
This short review highlights the effect of electrolytes on the performance of proteins-mesoporous silica conjugates which can open interesting perspectives in biotechnological fields, particularly nanomedicine and biocatalysis. Indeed therapeutic proteins and peptides represent a challenging innovation for several kinds of diseases, but since their self-life in biological fluids is very short, they need a stealth protective carrier. Similarly, enzymes need a solid support to improve thermal stability and to allow for recycling. Ordered mesoporous silica materials represent a valid choice as widely demonstrated. Both proteins and silica mesoporous materials possess charged surfaces, and here, the crucial role of pH, buffer, ionic strength and electrolyte type is posed in relation with loading/release of proteins onto/from the silica support through the analysis of adsorption and release processes. A delicate interplay of electrostatic and van der Waals interactions arises from considering electrolytes' effects on the two different charged surfaces. Clear outcomes concern the effect of pH and ionic strength. Protein loading onto the silica matrix is favored by an adsorbing solution having a pH close to the protein pI, and by a high ionic strength that reduces the Debye length. Release is instead favored by an adsorbing solution characterized by an intermediate ionic strength, close to the physiological values. Significant specific ions effects are shown to affect both proteins and silica matrices, as well as protein adsorption onto silica matrices. Further work is needed to quantify specific ion effects on the preservation of the biological activity, and on the release performance. Copyright © 2015 Elsevier B.V. All rights reserved.
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Molecular aspects of allergens in atopic dermatitis
Campana, Raffaela; Dzoro, Sheron; Mittermann, Irene; Fedenko, Elena; Elisyutina, Olga; Khaitov, Musa; Karaulov, Alexander; Valenta, Rudolf
2017-01-01
Purpose of review Molecular allergology uses pure, mainly recombinant and structurally defined allergen molecules and allergen-derived epitopes to study mechanisms of IgE-associated allergy, to diagnose, and even predict the development of allergic manifestations and to treat and prevent IgE-associated allergies. Atopic dermatitis, a chronic inflammatory skin disease is almost always associated with IgE sensitization to allergens. However, also non-IgE-mediated pathomechanisms seem to be operative in atopic dermatitis and it is often difficult to identify the disease-causing allergens. Here we review recent work showing the usefulness of molecular allergology to study mechanisms of atopic dermatitis, for diagnosis and eventually for treatment and prevention of atopic dermatitis. Recent findings IgE sensitization to airborne, food-derived, microbial allergens, and autoallergens has been found to be associated with atopic dermatitis. Using defined allergen molecules and non-IgE-reactive allergen derivatives, evidence could be provided for the existence of IgE- and non-IgE-mediated mechanisms of inflammation in atopic dermatitis. Furthermore, effects of epicutaneous allergen administration on systemic allergen-specific immune responses have been studied. Multi-allergen tests containing micro-arrayed allergen molecules have been shown to be useful for the identification of culprit allergens in atopic dermatitis and may improve the management of atopic dermatitis by allergen-specific immunotherapy, allergen avoidance, and IgE-targeting therapies in a personalized medicine approach. Summary Molecular allergology allows for dissection of the pathomechanisms of atopic dermatitis, provides new forms of allergy diagnosis for identification of disease-causing allergens, and opens the door to new forms of management by allergen-specific and T cells-targeting or IgE-targeting interventions in a personalized medicine approach. PMID:28622169
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Roduit, Caroline; Wohlgensinger, Johanna; Frei, Remo; Bitter, Sondhja; Bieli, Christian; Loeliger, Susanne; Büchele, Gisela; Riedler, Josef; Dalphin, Jean-Charles; Remes, Sami; Roponen, Marjut; Pekkanen, Juha; Kabesch, Michael; Schaub, Bianca; von Mutius, Erika; Braun-Fahrländer, Charlotte; Lauener, Roger
2011-01-01
Cross-sectional studies have suggested that prenatal farm exposures might protect against allergic disease and increase the expression of receptors of the innate immune system. However, epidemiologic evidence supporting the association with atopic dermatitis remains inconsistent. To study the association between prenatal farm-related exposures and atopic dermatitis in a prospective study. We further analyzed the association between the expression of innate immune genes at birth and atopic dermatitis. A total of 1063 children who participated in a birth cohort study, Protection against Allergy-Study in Rural Environments, were included in this study. Doctor diagnosis of atopic dermatitis was reported by the parents from 1 to 2 years of age by questionnaire. Gene expression of Toll-like receptors (TLRs) and CD14 was assessed in cord blood leukocytes by quantitative PCR. Maternal contact with farm animals and cats during pregnancy had a significantly protective effect on atopic dermatitis in the first 2 years of life. The risk of atopic dermatitis was reduced by more than half among children with mothers having contact with 3 or more farm animal species during pregnancy compared with children with mothers without contact (adjusted odds ratio, 0.43; 95% CI, 0.19-0.97). Elevated expression of TLR5 and TLR9 in cord blood was associated with decreased doctor diagnosis of atopic dermatitis. A significant interaction between polymorphism in TLR2 and prenatal cat exposure was observed in atopic dermatitis. Maternal contact with farm animals and cats during pregnancy has a protective effect on the development of atopic dermatitis in early life, which is associated with a lower expression of innate immune receptors at birth. Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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2012-01-01
Background Skin prick test (SPT) and fluorescence enzyme immunoassay (FEIA) are widely used for the diagnosis of Immunoglobulin-E (IgE)-mediated allergic disease. Basophil activation test (BAT) could obviate disadvantages of SPT and FEIA. However, it is not known whether BAT gives similar results as SPT or FEIA for aeroallergens. Objectives In this study, we compared the results of SPT, BAT and FEIA for different aeroallergens. Methods We performed BAT, SPT and FEIA in 41 atopic subjects (symptomatic and with positive SPT for at least 1 of 9 common aeroallergens) and 31 non-atopic subjects (asymptomatic and with negative SPT). Results Correlations between SPT and BAT, SPT and FEIA, and BAT and FEIA results were statistically significant but imperfect. Using SPT as the "gold standard", BAT and FEIA were similar in sensitivity. However, BAT had lower specificity than FEIA. False positive (BATposSPTneg) results were frequent in those atopic subjects who were allergic by SPT to a different allergen and rare in non-atopic subjects. The false positivity in atopic subjects was due in part to high levels of serum Total-IgE (T-IgE) levels in atopic individuals that lead to basophil activation upon staining with fluorochrome-labeled anti-IgE. Conclusion As an alternative to SPT in persons allergic to aeroallergens, BAT in its present form is useful for distinguishing atopic from non-atopic persons. However, BAT in its present form is less specific than FEIA when determining the allergen which a patient is allergic to. This is due to IgE staining-induced activation of atopic person's basophils and/or nonspecific hyperreactivity of atopic person's basophils. PMID:22264407
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El-Heis, S; Crozier, SR; Healy, E; Robinson, SM; Harvey, NC; Cooper, C; Inskip, HM; Baird, J; Godfrey, KM
2017-01-01
Background Perinatal maternal stress and low mood have been linked to offspring atopic eczema. Objectives To examine the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on stress/psychological distress preconception. Methods At recruitment in the UK Southampton Women’s Survey, preconception maternal reports of perceived stress in daily living and the effect of stress on health were recorded; in a sub-sample psychological distress was assessed (12-item General Health Questionnaire). Infants were followed up at ages 6 (n=2956) and 12 (n=2872) months and atopic eczema ascertained (based on UK Working Party Criteria for the Definition of Atopic Dermatitis). At 6 months postpartum, mothers were asked if they had experienced symptoms of low mood since childbirth and completed the Edinburgh Post-natal Depression Scale. Results Preconception perceived stress affecting health (OR 1.21 (95%CI 1.08-1.35), p=0.001) and stress in daily living (OR 1.16 (1.03-1.30), p=0.014) were associated with an increased risk of offspring atopic eczema at age 12 months but not at 6 months, robust to adjustment for potentially confounding variables. Findings were similar for maternal psychological distress preconception. Low maternal mood between delivery and 6 months postpartum was associated with an increased risk of infantile atopic eczema at age 12 months, but no significant association between postnatal mood and atopic eczema was seen after taking account of preconception stress. Conclusion & Clinical Relevance Our data provide novel evidence linking maternal stress at preconception to atopic eczema risk, supporting a developmental contribution to the aetiology of atopic eczema and pointing to potentially modifiable influences. PMID:28218994
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Analysis of sitting forces on stationary chairs for daily activities.
Hu, Lingling; Tackett, Bob; Tor, Onder; Zhang, Jilei
2016-04-01
No literature related to the study of sitting forces on chairs sat on by people who weighed over 136 kg was found. The Business Institutional Furniture Manufactures Association needs force data for development of performance test standards to test chairs for users who weigh up to 181 kg. 20 participants who weighed from 136 to 186 kg completed 6 tasks on an instrumented chair in the sequence of sitting down, remaining seated and rising. Effects of sitting motion, armrest use and seat cushion thickness on vertical sitting forces and centre-of-force were investigated. Results indicated hard sitting down yielded the highest sitting force of 213% in terms of participants' body weights. Armrest use affected sitting forces of normal sitting down, but not of rising and hard sitting down. Cushion thickness affected sitting forces of normal and hard sitting down and shifting, but not of rising, static seating or stretching backward situations. Practitioner Summary: Results of the sitting force and centre-of-force data obtained for this research can help furniture manufacturers develop new product performance test standards for creating reliable engineering design and manufacturing quality and durable products to meet a niche market need.
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Genetic polymorphism of the beta-2 adrenergic receptor in atopic and non-atopic subjects.
Potter, P C; Van Wyk, L; Martin, M; Lentes, K U; Dowdle, E B
1993-10-01
To investigate a possible genetic basis for reported differences in beta-2 receptor expression in atopic subjects, DNA from 42 atopic children (22 asthmatics and 22 with allergic rhinitis) and 30 non-atopic subjects was Southern blotted and Ban-1 restriction fragment polymorphisms (RFLPS) were studied using a 2.6 kb probe of the human beta-2 receptor gene. Two alleles 3.1 kb and 2.9 kb were identified. Homozygotes and heterozygotes for the two alleles were found with equal frequency in the atopic patients who had asthma and in those who had allergic rhinitis only. The gene frequencies for the upper and lower alleles were 0.45 and 0.55 respectively. Our studies do not provide evidence for an association between a particular polymorphic form of the human beta-2 receptor gene and atopy.
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Bradley, Charles W; Morris, Daniel O; Rankin, Shelley C; Cain, Christine L; Misic, Ana M; Houser, Timothy; Mauldin, Elizabeth A; Grice, Elizabeth A
2016-06-01
Host-microbe interactions may play a fundamental role in the pathogenesis of atopic dermatitis, a chronic relapsing inflammatory skin disorder characterized by universal colonization with Staphylococcus species. To examine the relationship between epidermal barrier function and the cutaneous microbiota in atopic dermatitis, this study used a spontaneous model of canine atopic dermatitis. In a cohort of 14 dogs with canine atopic dermatitis, the skin microbiota were longitudinally evaluated with parallel assessment of skin barrier function at disease flare, during antimicrobial therapy, and post-therapy. Sequencing of the bacterial 16S ribosomal RNA gene showed decreased bacterial diversity and increased proportions of Staphylococcus (S. pseudintermedius in particular) and Corynebacterium species compared with a cohort of healthy control dogs (n = 16). Treatment restored bacterial diversity with decreased proportions of Staphylococcus species, concurrent with decreased canine atopic dermatitis severity. Skin barrier function, as measured by corneometry, pH, and transepidermal water loss also normalized with treatment. Bacterial diversity correlated with transepidermal water loss and pH level but not with corneometry results. These findings provide insights into the relationship between the cutaneous microbiome and skin barrier function in atopic dermatitis, show the impact of antimicrobial therapy on the skin microbiome, and highlight the utility of canine atopic dermatitis as a spontaneous nonrodent model of atopic dermatitis. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
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Čelakovská, Jarmila; Bukač, Josef
2014-01-01
Background: A few reports demonstrate the comorbidity of food allergy and allergic march in adult patients. Aims and Objectives: To evaluate, if there is some relation in atopic dermatitis patients at the age 14 years and older who suffer from food allergy to common food allergens to other allergic diseases and parameters as bronchial asthma, allergic rhinitis, duration of atopic dermatitis, family history and onset of atopic dermatitis. Materials and Methods: Complete dermatological and allergological examination was performed; these parameters were examined: food allergy (to wheat flour, cow milk, egg, peanuts and soy), the occurrence of bronchial asthma, allergic rhinitis, duration of atopic dermatitis, family history and onset of atopic dermatitis. The statistical evaluation of the relations among individual parameters monitored was performed. Results: Food allergy was altogether confirmed in 65 patients (29%) and these patients suffer significantly more often from bronchial asthma and allergic rhinitis. Persistent atopic dermatitis lesions and positive data in family history about atopy are recorded significantly more often in patients with confirmed food allergy to examined foods as well. On the other hand, the onset of atopic dermatitis under 5 year of age is not recorded significantly more often in patients suffering from allergy to examined foods. Conclusion: Atopic dermatitis patients suffering from food allergy suffer significantly more often from allergic rhinitis, bronchial asthma, persistent eczematous lesions and have positive data about atopy in their family history. PMID:25284847
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Cho, Byoung Ok; Che, Denis Nchang; Yin, Hong Hua; Shin, Jae Young; Jang, Seon Il
2017-05-01
Atopic dermatitis, a chronic relapsing and pruritic inflammation of the skin also thought to be involved in, or caused by immune system destruction is an upsetting health problem due to its continuously increasing incidence especially in developed countries. Mast cell infiltration in atopic dermatitis skin lesions and its IgE-mediated activation releases various cytokines and chemokines that have been implicated in the pathogenesis of atopic dermatitis. This study was aimed at investigating synergistic anti-inflammatory, anti-pruritic and anti-atopic dermatitis effects of Diospyros lotus leaf extract (DLE) and Muscat bailey A grapefruit stem extract (GFSE) in atopic dermatitis-like induced skin lesions in mice. Combinations of DLE and GFSE inhibited TNF-α and IL-6 production more than DLE or GFSE in PMA plus calcium ionophore A23187-activated HMC-1 cells. DLE and GFSE synergistically inhibited compound 48/80-induced dermal infiltration of mast cells and reduced scratching behavior than DLE or GFSE. Furthermore, DLE and GFSE synergistically showed a stronger ameliorative effect in skin lesions by reducing clinical scores; dermal infiltration of mast cells; ear and dorsal skin thickness; serum IgE and IL-4 production in atopic dermatitis-like mice. Collectively, these results suggest that DLE and GFSE synergistically exhibit anti-atopic dermatitis effects in atopic dermatitis-like skin lesions in mice. Copyright © 2017. Published by Elsevier Masson SAS.
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Risk factors for atopic and non-atopic asthma in a rural area of Ecuador.
Moncayo, Ana Lucia; Vaca, Maritza; Oviedo, Gisela; Erazo, Silvia; Quinzo, Isabel; Fiaccone, Rosemeire L; Chico, Martha E; Barreto, Mauricio L; Cooper, Philip J
2010-05-01
BACKGROUND Asthma has emerged as an important public health problem of urban populations in Latin America. Epidemiological data suggest that a minority of asthma cases in Latin America may be associated with allergic sensitisation and that other mechanisms causing asthma have been overlooked. The aim of the present study was to investigate risk factors for atopic and non-atopic asthma in school-age children. METHODS A cross-sectional study was conducted among 3960 children aged 6-16 years living in Afro-Ecuadorian rural communities in Esmeraldas province in Ecuador. Allergic diseases and risk factors were assessed by questionnaire and allergic sensitisation by allergen skin prick reactivity. RESULTS A total of 390 (10.5%) children had wheeze within the previous 12 months, of whom 14.4% had at least one positive skin test. The population-attributable fraction for recent wheeze associated with atopy was 2.4%. Heavy Trichuris trichiura infections were strongly inversely associated with atopic wheeze. Non-atopic wheeze was positively associated with maternal allergic symptoms and sedentarism (watching television (>3 h/day)) but inversely associated with age and birth order. CONCLUSIONS The present study showed a predominance of non-atopic compared with atopic wheeze among schoolchildren living in a poor rural region of tropical Latin America. Distinct risk factors were associated with the two wheeze phenotypes and may indicate different causal mechanisms. Future preventive strategies in such populations may need to be targeted at the causes of non-atopic wheeze.
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Toxocariasis might be an important cause of atopic myelitis in Korea.
Lee, Jin-Young; Kim, Byoung-Joon; Lee, Sang-Pyo; Jeung, Yun-Jin; Oh, Mi-Jung; Park, Min-Su; Paeng, Jae-Won; Lee, Byung-Jae; Choi, Dong-Chull
2009-12-01
Atopic myelitis is defined as myelitis with atopic diasthesis but the cause is still unknown. Toxocariasis is one of the common causes of hyperIgEaemia that may lead to neurologic manifestations. The purpose of this study was to evaluate the sero-prevalence of Toxocara specific IgG Ab among the atopic myelitis patients. We evaluated the medical records of 37 patients with atopic myelitis whose conditions were diagnosed between March 2001 and August 2007. Among them, the 33 sera were analyzed for specific serum IgG Ab to Toxocara excretory-secretory antigens (TES). All of 37 patients had hyperIgEaemia. Specific IgE to D. pteronyssinus and D. farinae was detected in 22 (64.7%) and 34 (100%) patients, respectively, of the 34 patients. Thirty-one of 33 patients (93.9%) were found to be positive by TES IgG enzyme-linked immunosorbent assay (ELISA). Based on the image findings of eosinophilic infiltrations in the lung and liver, 8 patients had positive results. These results inferred that the prevalence of toxocariasis was high in patients with atopic myelitis. Our results suggest that toxocariasis might be an important cause of atopic myelitis and Toxocara ELISA is essential for evaluating the causes of atopic myelitis.
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Toxocariasis Might be an Important Cause of Atopic Myelitis in Korea
Lee, Jin-Young; Kim, Byoung-Joon; Lee, Sang-Pyo; Jeung, Yun-Jin; Oh, Mi-Jung; Park, Min-Su; Paeng, Jae-Won; Lee, Byung-Jae
2009-01-01
Atopic myelitis is defined as myelitis with atopic diasthesis but the cause is still unknown. Toxocariasis is one of the common causes of hyperIgEaemia that may lead to neurologic manifestations. The purpose of this study was to evaluate the sero-prevalence of Toxocara specific IgG Ab among the atopic myelitis patients. We evaluated the medical records of 37 patients with atopic myelitis whose conditions were diagnosed between March 2001 and August 2007. Among them, the 33 sera were analyzed for specific serum IgG Ab to Toxocara excretory-secretory antigens (TES). All of 37 patients had hyperIgEaemia. Specific IgE to D. pteronyssinus and D. farinae was detected in 22 (64.7%) and 34 (100%) patients, respectively, of the 34 patients. Thirty-one of 33 patients (93.9%) were found to be positive by TES IgG enzyme-linked immunosorbent assay (ELISA). Based on the image findings of eosinophilic infiltrations in the lung and liver, 8 patients had positive results. These results inferred that the prevalence of toxocariasis was high in patients with atopic myelitis. Our results suggest that toxocariasis might be an important cause of atopic myelitis and Toxocara ELISA is essential for evaluating the causes of atopic myelitis. PMID:19949655
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Decreased natural killer cell activity in atopic eczema.
Hall, T J; Rycroft, R; Brostoff, J
1985-01-01
We have studied NK cell activity in atopic and non-atopic subjects using a standard 51Cr-release assay and K562 target cells. In atopics (AT) with allergic rhinitis and/or asthma, NK cell activity was similar to that in non-atopic (N) subjects, whilst patients with severe atopic eczema (AE) had depressed NK cell activity compared to AT or N subjects. In addition, circulating T-cell numbers and Con A responsiveness was decreased in AE, although neither parameter was correlated with decreased NK cell activity. However, decreased NK cell activity in atopic eczema was positively correlated with decreased numbers of Fc gamma + lymphocytes (P = 0.01) and decreased effector: target cell binding (P = 0.05), and negatively correlated with increased monocytes in AE (P = 0.09). AE NK cell activity was equally or more sensitive to the inhibitory effects of drugs such as dibutyryl cyclic AMP, prostaglandins (PG) D2,E2 and histamine. The relative percentage increase in NK cell activity by the interferon inducer poly I:C was similar in AE patients and controls. The results suggest that reduced numbers of circulating NK cells and pre-NK cells account for the depressed level of NK cell activity in subjects with severe atopic eczema. PMID:3876984
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Oh, Jae-Won; Pyun, Bok-Yang; Choung, Ji-Tae; Ahn, Kang-mo; Kim, Chul-Hong; Song, Sang-Wook; Son, Jin-Ah; Lee, Soo-young
2004-01-01
Little is known about the prevalence of atopic dermatitis and food allergy outside North America and Europe. We evaluated the prevalence of atopic dermatitis and food allergy with the comparison of prevalence between 1995 and 2000 in Korea and evaluated the correlation of prevalence between atopic dermatitis and food allergy. A cross-sectional questionnaire survey was conducted on random samples of schoolchildren 6 to 14 yr at two time points, 1995 and 2000 throughout Korea. The last twelve months prevalence of atopic dermatitis in Korean school-aged children was increased from 1995 to 2000. The twelve-month prevalence of atopic dermatitis and food allergy were higher in Seoul than in any other provincial cities in 1995, but the prevalence of both diseases in Seoul and Provincial Centers became to be similar in 2000. The rate responded to food allergy of children with atopic dermatitis (9.5%) was lower than that of the western countries (60%). And our data demonstrated paternal and maternal allergy history is very significantly correlated to developing atopic dermatitis in their offspring. The further objective evaluations are required to confirm these outcomes because the environmental and risk factors may be different among the countries according to their living cultures. PMID:15483350
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Resolving the Etiology of Atopic Disorders by Genetic Analysis of Racial Ancestry
Gupta, Jayanta; Johansson, Elisabet; Bernstein, Jonathan A.; Chakraborty, Ranajit; Khurana Hershey, Gurjit K.; Rothenberg, Marc E.; Mersha, Tesfaye B.
2016-01-01
Atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR) and asthma are common atopic disorders of complex etiology. The frequently observed “atopic march” from early AD to asthma and/or AR later in life as well as the extensive comorbidity of atopic disorders, suggests common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African-Americans when compared to European-Americans. Whether this disparity stems from true genetic or race-specific environmental risk factors or both is unknown. Thus far, the majority of the genetic studies on atopic diseases have utilized populations of European ancestry, limiting their generalizability. Large cohort initiatives and new analytic methods such as admixture mapping are currently being employed to address this knowledge gap. Here we discuss the unique and shared genetic risk factors for atopic disorders in the context of ancestry variations, and the promise of high-throughput “-omics” based systems biology approach in providing greater insight to deconstruct into their genetic and non-genetic etiologies. Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, gene-environment, and gene-gene interactions. PMID:27297995
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Measurement of the Relative Fragmentation Fractions of B-bar Hadrons
DOE Office of Scientific and Technical Information (OSTI.GOV)
Gibson, Karen Ruth
This thesis describes the first Run II measurement of b quark fragmentation intomore » $$\\bar{B}$$ 0, B -, and B$$0\\atop{s}$$ mesons and Λ$$0\\atop{b}$$ baryons using semileptonic B decays. The result is based on 360 pb -1 of data collected with the CDF detector in p$$\\bar{p}$$ collisions at √s = 1,960 GeV at the Tevatron Collider at Fermilab. The fragmentation fractions are measured for an effective $$\\bar{B}$$ hadron p T threshold of 7 GeV/c to be f u/f d = 1.054 ± 0.018(stat)$$+0.025\\atop{-0.045}$$(syst) ± 0.058(BR), f s/(f u + f d) = 0.160 ± 0.005(stat)$$+0.011\\atop{-0.010}$$(syst)Λ$$+0.057\\atop{-0.034}$$(BR), and f Λb/(f u + f d) = 0.281 ± 0.012(stat)$$+0.058\\atop{-0.056}$$(syst)$$+0.128\\atop{-0.086}$$(BR). f s/(f u + f d) agrees both with previous CDF measurements and the world averages, dominated by the LEP measurements, with ~ 1σ. However, f Λb/(f u + f d) is approximately twice the value which has been measured at LEP and in CDF Run I and disagrees with the LEP results by approximately 2 σ.« less
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Barbieri, Dechristian França; Srinivasan, Divya; Mathiassen, Svend Erik; Oliveira, Ana Beatriz
2017-08-01
We compared usage patterns of two different electronically controlled sit-stand tables during a 2-month intervention period among office workers. Office workers spend most of their working time sitting, which is likely detrimental to health. Although the introduction of sit-stand tables has been suggested as an effective intervention to decrease sitting time, limited evidence is available on usage patterns of sit-stand tables and whether patterns are influenced by table configuration. Twelve workers were provided with standard sit-stand tables (nonautomated table group) and 12 with semiautomated sit-stand tables programmed to change table position according to a preset pattern, if the user agreed to the system-generated prompt (semiautomated table group). Table position was monitored continuously for 2 months after introducing the tables, as a proxy for sit-stand behavior. On average, the table was in a "sit" position for 85% of the workday in both groups; this percentage did not change significantly during the 2-month period. Switches in table position from sit to stand were, however, more frequent in the semiautomated table group than in the nonautomated table group (0.65 vs. 0.29 hr -1 ; p = .001). Introducing a semiautomated sit-stand table appeared to be an attractive alternative to a standard sit-stand table, because it led to more posture variation. A semiautomated sit-stand table may effectively contribute to making postures more variable among office workers and thus aid in alleviating negative health effects of extensive sitting.
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Atopic dermatitis: professional orientation.
Frimat, Paul; Boughattas, Wided; Even, Dorothée
2015-01-01
Atopic dermatitis is often exacerbated by the working environment. In order to reduce the risk of allergy, young people must receive better medical guidance when they choose a career. This is all the more relevant for young atopic patients.
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Just, Helle L; Deleuran, Mette; Vestergaard, Christian; Deleuran, Bent; Thestrup-Pedersen, Kristian
2008-01-01
We used T-cell receptor excision circles (TREC) to evaluate thymic function in adult patients with atopic dermatitis and psoriasis. We observed that men, but not women, with atopic dermatitis had a significantly faster decline in TREC content with increasing age compared with healthy men. In contrast, both men and women with psoriasis had significantly reduced TREC levels, which were, on average, only 30% of that of healthy persons. In atopic dermatitis the levels of TREC declined with increasing levels of IgE, disease intensity and extent of eczema. Furthermore, patients with atopic dermatitis showed signs of altered thymus function, as they had a significantly greater variation in TREC content measured over time than healthy controls, especially within the CD8+ T-cell subpopulation. Because both atopic dermatitis and psoriasis patients have an increased number of T-cells, this indicates that atopic dermatitis patients can have compensatory emissions of thymic emigrants, whereas psoriatic patients do not, thus supporting different thymic function in these two diseases.
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London-born black Caribbean children are at increased risk of atopic dermatitis.
Williams, H C; Pembroke, A C; Forsdyke, H; Boodoo, G; Hay, R J; Burney, P G
1995-02-01
Previous reports suggest that atopic dermatitis is more common in black Caribbean children born in the United Kingdom than in white children. It is unclear whether these differences are caused by selection bias or variations in the use of the word "eczema" in the groups studied. Our objective was to explore ethnic group differences in the prevalence of atopic dermatitis in London schoolchildren. A cross-sectional prevalence survey of 693 junior school children in three schools was performed. Atopic dermatitis was defined in three ways: (1) by a dermatologist, (2) by visible flexural dermatitis as recorded by an independent observer, and (3) by a history of flexural dermatitis according to the child's parents. The prevalence of atopic dermatitis according to examination by a dermatologist was 16.3% in black Caribbean children and 8.7% in white children. This increased risk was present for different methods of defining of a atopic dermatitis and persisted after adjustment for potential confounders. London-born black Caribbean children appear to be at an increased risk of having atopic dermatitis.
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Molecular dynamics simulations of polyethers and a quaternary ammonium ionic liquid as CO2 absorbers
NASA Astrophysics Data System (ADS)
Cardoso, Piercarlo Fortunato; Fernandez, Juan S. L. C.; Lepre, Luiz Fernando; Ando, Rômulo Augusto; Costa Gomes, Margarida F.; Siqueira, Leonardo J. A.
2018-04-01
The properties of mixtures of butyltrimethylammonium bis(trifluoromethylsulfonyl)imide, [N4111][NTf2], with poly(ethyleneglycol) dimethyl ether, PEO, were described as a function of PEO chain size by molecular dynamics simulations. Both PEO chain size and mixture composition revealed to play a significant role in determining the structure and the dynamics of the fluids. The remarkably higher viscosity observed for mixtures composed by 0.25 mole fraction of PEO was attributed to the increase in the gauche population of OCCO dihedral of the polyether of longer chains. The negative solvation enthalpy (ΔsolH < 0) and entropy (ΔsolS < 0) revealed a favorable CO2 absorption by the neat and mixture systems. The CO2 absorption was higher in neat PEO, particularly considering longer chains. The gas solubility in the mixtures presented intermediate values in comparison to the neat PEO and neat ionic liquid. The CO2 solutions had their structures discussed in the light of the calculated radial and spatial distribution functions.
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Selective concentration of aromatic bases from water with a resin adsorbent
Stuber, H.A.; Leenheer, J.A.
1983-01-01
Aromatic bases are concentrated from water on columns of a resin adsorbent and recovered by aqueous-acid elution. The degree of concentration attainable depends on the ratio of the capacity factor (k) of the neutral form of the amine to that of the ionized form. Capacity factors of ionic forms of amines on XAD-8 resin (a methylacrylic ester polymer) are greater than zero, ranging from 20 to 250 times lower than those of their neutral forms; they increase with increasing hydrophobicity of the amine. Thus, desorption by acid is an edition (k during desorption >0) rather than a displacement (k during desorption = 0) process. The degree of concentration attainable on XAD-8 resin varies with the hydrophobicity of the amine, being limited for hydrophilic solutes (for example, pyridine) by small neutral-form k's, reaching a maximum for amines of intermediate hydrophobicity (for example, quinoline), and decreasing for more hydrophobc solutes (for example, acridine) because of their large ionic-form k's.
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Zhao, Yanfei; Wu, Yunyan; Yuan, Guangfeng; Hao, Leiduan; Gao, Xiang; Yang, Zhenzhen; Yu, Bo; Zhang, Hongye; Liu, Zhimin
2016-10-06
The chemical transformation of atmospheric CO 2 is of great significance yet still poses a great challenge. Herein, azole-anion-based aprotic ionic liquids (ILs) were synthesized by the deprotonation of weak proton donors (e.g., 2-methylimidazole, 4-methylimidazole, and 2,4-dimethylimidazole) with tetrabutylphosphonium hydroxide, [Bu 4 P][OH]. We found that these ILs, such as [Bu 4 P][2-MIm], could activate atmospheric CO 2 through the formation of carbamates. The resultant carbamate intermediates could further react with various types of substrate, including propargylic alcohols, 2-aminobenzonitriles, ortho-phenylenediamines, and 2-aminothiophenol, thereby producing α-alkylidene cyclic carbonates, quinazoline-2,4(1 H,3 H)-diones, benzimidazolones, and benzothiazoline, respectively, in moderate-to-good yields. Thus, we have achieved the transformation of CO 2 at atmospheric pressure, and we expect this method to open up new routes for the synthesis of various oxygen-containing heterocyclic compounds under metal-free conditions. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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NASA Astrophysics Data System (ADS)
Yoshii, Noriyuki; Nimura, Yuki; Fujimoto, Kazushi; Okazaki, Susumu
2017-07-01
The surface structure and its fluctuation of spherical micelles were investigated using a series of density correlation functions newly defined by spherical harmonics and Legendre polynomials based on the molecular dynamics calculations. To investigate the influence of head-group charges on the micelle surface structure, ionic sodium dodecyl sulfate and nonionic octaethyleneglycol monododecylether (C12E8) micelles were investigated as model systems. Large-scale density fluctuations were observed for both micelles in the calculated surface static structure factor. The area compressibility of the micelle surface evaluated by the surface static structure factor was tens-of-times larger than a typical value of a lipid membrane surface. The structural relaxation time, which was evaluated from the surface intermediate scattering function, indicates that the relaxation mechanism of the long-range surface structure can be well described by the hydrostatic approximation. The density fluctuation on the two-dimensional micelle surface has similar characteristics to that of three-dimensional fluids near the critical point.
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Yoshii, Noriyuki; Nimura, Yuki; Fujimoto, Kazushi; Okazaki, Susumu
2017-07-21
The surface structure and its fluctuation of spherical micelles were investigated using a series of density correlation functions newly defined by spherical harmonics and Legendre polynomials based on the molecular dynamics calculations. To investigate the influence of head-group charges on the micelle surface structure, ionic sodium dodecyl sulfate and nonionic octaethyleneglycol monododecylether (C 12 E 8 ) micelles were investigated as model systems. Large-scale density fluctuations were observed for both micelles in the calculated surface static structure factor. The area compressibility of the micelle surface evaluated by the surface static structure factor was tens-of-times larger than a typical value of a lipid membrane surface. The structural relaxation time, which was evaluated from the surface intermediate scattering function, indicates that the relaxation mechanism of the long-range surface structure can be well described by the hydrostatic approximation. The density fluctuation on the two-dimensional micelle surface has similar characteristics to that of three-dimensional fluids near the critical point.
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NASA Astrophysics Data System (ADS)
Smolko, Lukáš; Černák, Juraj; Kuchár, Juraj; Miklovič, Jozef; Boča, Roman
2016-09-01
Green crystals of Co(III)/Co(II) mixed valence compound [Co(bapen)Br2]2[CoBr4] (bapen = N,N‧-bis(3-aminopropyl)ethane-1,2-diamine) were isolated from the aqueous system CoBr2 - bapen - HBr, crystallographically studied and characterized by elemental analysis and IR spectroscopy. Its ionic crystal structure is built up of [Co(bapen)Br2]+ cations and [CoBr4]2- anions. The Co(III) central atoms within the complex cations are hexacoordinated (donor set trans-N4Br2) with bromido ligands placed in the axial positions. The Co(II) atoms exhibit distorted tetrahedral coordination. Beside ionic forces weak Nsbnd H⋯Br intermolecular hydrogen bonding interactions contribute to the stability of the structure. Temperature variable magnetic measurements confirm the S = 3/2 behavior with the zero-field splitting of an intermediate strength: D/hc = 8.7 cm-1.
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Cardoso, Piercarlo Fortunato; Fernandez, Juan S L C; Lepre, Luiz Fernando; Ando, Rômulo Augusto; Costa Gomes, Margarida F; Siqueira, Leonardo J A
2018-04-07
The properties of mixtures of butyltrimethylammonium bis(trifluoromethylsulfonyl)imide, [N 4111 ][NTf 2 ], with poly(ethyleneglycol) dimethyl ether, PEO, were described as a function of PEO chain size by molecular dynamics simulations. Both PEO chain size and mixture composition revealed to play a significant role in determining the structure and the dynamics of the fluids. The remarkably higher viscosity observed for mixtures composed by 0.25 mole fraction of PEO was attributed to the increase in the gauche population of OCCO dihedral of the polyether of longer chains. The negative solvation enthalpy (Δ sol H < 0) and entropy (Δ sol S < 0) revealed a favorable CO 2 absorption by the neat and mixture systems. The CO 2 absorption was higher in neat PEO, particularly considering longer chains. The gas solubility in the mixtures presented intermediate values in comparison to the neat PEO and neat ionic liquid. The CO 2 solutions had their structures discussed in the light of the calculated radial and spatial distribution functions.
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Atomic and electronic structures of an extremely fragile liquid.
Kohara, Shinji; Akola, Jaakko; Patrikeev, Leonid; Ropo, Matti; Ohara, Koji; Itou, Masayoshi; Fujiwara, Akihiko; Yahiro, Jumpei; Okada, Junpei T; Ishikawa, Takehiko; Mizuno, Akitoshi; Masuno, Atsunobu; Watanabe, Yasuhiro; Usuki, Takeshi
2014-12-18
The structure of high-temperature liquids is an important topic for understanding the fragility of liquids. Here we report the structure of a high-temperature non-glass-forming oxide liquid, ZrO2, at an atomistic and electronic level. The Bhatia-Thornton number-number structure factor of ZrO2 does not show a first sharp diffraction peak. The atomic structure comprises ZrO5, ZrO6 and ZrO7 polyhedra with a significant contribution of edge sharing of oxygen in addition to corner sharing. The variety of large oxygen coordination and polyhedral connections with short Zr-O bond lifetimes, induced by the relatively large ionic radius of zirconium, disturbs the evolution of intermediate-range ordering, which leads to a reduced electronic band gap and increased delocalization in the ionic Zr-O bonding. The details of the chemical bonding explain the extremely low viscosity of the liquid and the absence of a first sharp diffraction peak, and indicate that liquid ZrO2 is an extremely fragile liquid.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Shirbhate, S. C.; Acharya, S. A., E-mail: saha275@yahoo.com; Yadav, A. K.
2016-04-04
This study provides atomic scale insight to understand the role of aliovalent dopants on oxygen vacancies clustering and dissociation mechanism in ceria system in order to enhance the performance of oxy-ion conductor. Dopants induced microscale changes in ceria are probed by extended X-ray absorption fine structure spectroscopy, X-ray absorption near edge spectra, and Raman spectroscopy. The results are explored to establish a correlation between atomic level structural changes (coordination number, interatomic spacing) → formation of dimer and trimer type cation-oxygen vacancies defect complex (intrinsic and extrinsic) → dissociation of oxygen vacancies from defect cluster → ionic conductivity temperature. It ismore » a strategic approach to understand key physics of ionic conductivity mechanism in order to reduce operating temperature of electrolytes for intermediate temperature (300–450 °C) electrochemical devices for the first time.« less
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Atomic and electronic structures of an extremely fragile liquid
Kohara, Shinji; Akola, Jaakko; Patrikeev, Leonid; Ropo, Matti; Ohara, Koji; Itou, Masayoshi; Fujiwara, Akihiko; Yahiro, Jumpei; Okada, Junpei T.; Ishikawa, Takehiko; Mizuno, Akitoshi; Masuno, Atsunobu; Watanabe, Yasuhiro; Usuki, Takeshi
2014-01-01
The structure of high-temperature liquids is an important topic for understanding the fragility of liquids. Here we report the structure of a high-temperature non-glass-forming oxide liquid, ZrO2, at an atomistic and electronic level. The Bhatia–Thornton number–number structure factor of ZrO2 does not show a first sharp diffraction peak. The atomic structure comprises ZrO5, ZrO6 and ZrO7 polyhedra with a significant contribution of edge sharing of oxygen in addition to corner sharing. The variety of large oxygen coordination and polyhedral connections with short Zr–O bond lifetimes, induced by the relatively large ionic radius of zirconium, disturbs the evolution of intermediate-range ordering, which leads to a reduced electronic band gap and increased delocalization in the ionic Zr–O bonding. The details of the chemical bonding explain the extremely low viscosity of the liquid and the absence of a first sharp diffraction peak, and indicate that liquid ZrO2 is an extremely fragile liquid. PMID:25520236
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Yang, Qu; Zhou, Ziyao; Wang, Liqian; Zhang, Hongjia; Cheng, Yuxin; Hu, Zhongqiang; Peng, Bin; Liu, Ming
2018-05-01
To meet the demand of developing compatible and energy-efficient flexible spintronics, voltage manipulation of magnetism on soft substrates is in demand. Here, a voltage tunable flexible field-effect transistor structure by ionic gel (IG) gating in perpendicular synthetic anti-ferromagnetic nanostructure is demonstrated. As a result, the interlayer Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction can be tuned electrically at room temperature. With a circuit gating voltage, anti-ferromagnetic (AFM) ordering is enhanced or converted into an AFM-ferromagnetic (FM) intermediate state, accompanying with the dynamic domain switching. This IG gating process can be repeated stably at different curvatures, confirming an excellent mechanical property. The IG-induced modification of interlayer exchange coupling is related to the change of Fermi level aroused by the disturbance of itinerant electrons. The voltage modulation of RKKY interaction with excellent flexibility proposes an application potential for wearable spintronic devices with energy efficiency and ultralow operation voltage. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Pathways for virus assembly around nucleic acids
Perlmutter, Jason D; Perkett, Matthew R
2014-01-01
Understanding the pathways by which viral capsid proteins assemble around their genomes could identify key intermediates as potential drug targets. In this work we use computer simulations to characterize assembly over a wide range of capsid protein-protein interaction strengths and solution ionic strengths. We find that assembly pathways can be categorized into two classes, in which intermediates are either predominantly ordered or disordered. Our results suggest that estimating the protein-protein and the protein-genome binding affinities may be sufficient to predict which pathway occurs. Furthermore, the calculated phase diagrams suggest that knowledge of the dominant assembly pathway and its relationship to control parameters could identify optimal strategies to thwart or redirect assembly to block infection. Finally, analysis of simulation trajectories suggests that the two classes of assembly pathways can be distinguished in single molecule fluorescence correlation spectroscopy or bulk time resolved small angle x-ray scattering experiments. PMID:25036288
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The Role of Malassezia spp. in Atopic Dermatitis
Glatz, Martin; Bosshard, Philipp P.; Hoetzenecker, Wolfram; Schmid-Grendelmeier, Peter
2015-01-01
Malassezia spp. is a genus of lipophilic yeasts and comprises the most common fungi on healthy human skin. Despite its role as a commensal on healthy human skin, Malassezia spp. is attributed a pathogenic role in atopic dermatitis. The mechanisms by which Malassezia spp. may contribute to the pathogenesis of atopic dermatitis are not fully understood. Here, we review the latest findings on the pathogenetic role of Malassezia spp. in atopic dermatitis (AD). For example, Malassezia spp. produces a variety of immunogenic proteins that elicit the production of specific IgE antibodies and may induce the release of pro-inflammatory cytokines. In addition, Malassezia spp. induces auto-reactive T cells that cross-react between fungal proteins and their human counterparts. These mechanisms contribute to skin inflammation in atopic dermatitis and therefore influence the course of this disorder. Finally, we discuss the possible benefit of an anti-Malassezia spp. treatment in patients with atopic dermatitis. PMID:26239555
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Treatment of Atopic Dermatitis From the Perspective of Traditional Persian Medicine
Choopani, Rasool; Mehrbani, Mehrzad; Fekri, Alireza; Mehrabani, Mitra
2015-01-01
There is a strong current trend for using complementary and alternative medications to treat atopic dermatitis. Atopic dermatitis is a common, chronic, pruritic, and inflammatory skin disease. It can have a profound, negative effect on patients’ quality of life. Mild cases of atopic dermatitis can be controlled by the application of moisturizers and topical corticosteroids. However, in severe cases, application of immunosuppressive medication is unavoidable but it can have adverse effects. In traditional Persian medicine, diseases similar to resistant atopic dermatitis are treated with whey in combination with decoction of field dodder. Both whey and field dodder have anti-inflammatory properties. Consumption of whey can also aid skin repair, mitigate pruritus, and help combat the high level of stress experienced by patients. Therefore, it is hypothesized that consumption of traditional medicinal treatment of whey with decoction of field dodder can be applied as a complementary treatment for atopic dermatitis. PMID:26260045
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Hidaka, Takanori; Ogawa, Eisaku; Kobayashi, Eri H; Suzuki, Takafumi; Funayama, Ryo; Nagashima, Takeshi; Fujimura, Taku; Aiba, Setsuya; Nakayama, Keiko; Okuyama, Ryuhei; Yamamoto, Masayuki
2017-01-01
Atopic dermatitis is increasing worldwide in correlation with air pollution. Various organic components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor). Through the use of AhR-CA mice, whose keratinocytes express constitutively active AhR and that develop atopic-dermatitis-like phenotypes, we identified Artn as a keratinocyte-specific AhR target gene whose product (the neurotrophic factor artemin) was responsible for epidermal hyper-innervation that led to hypersensitivity to pruritus. The activation of AhR via air pollutants induced expression of artemin, alloknesis, epidermal hyper-innervation and inflammation. AhR activation and ARTN expression were positively correlated in the epidermis of patients with atopic dermatitis. Thus, AhR in keratinocytes senses environmental stimuli and elicits an atopic-dermatitis pathology. We propose a mechanism of air-pollution-induced atopic dermatitis via activation of AhR.
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Impact of increasing social media use on sitting time and body mass index.
Alley, Stephanie; Wellens, Pauline; Schoeppe, Stephanie; de Vries, Hein; Rebar, Amanda L; Short, Camille E; Duncan, Mitch J; Vandelanotte, Corneel
2017-08-01
Issue addressed Sedentary behaviours, in particular sitting, increases the risk of cardiovascular disease, type 2 diabetes, obesity and poorer mental health status. In Australia, 70% of adults sit for more than 8h per day. The use of social media applications (e.g. Facebook, Twitter, and Instagram) is on the rise; however, no studies have explored the association of social media use with sitting time and body mass index (BMI). Methods Cross-sectional self-report data on demographics, BMI and sitting time were collected from 1140 participants in the 2013 Queensland Social Survey. Generalised linear models were used to estimate associations of a social media score calculated from social media use, perceived importance of social media, and number of social media contacts with sitting time and BMI. Results Participants with a high social media score had significantly greater sitting times while using a computer in leisure time and significantly greater total sitting time on non-workdays. However, no associations were found between social media score and sitting to view TV, use motorised transport, work or participate in other leisure activities; or total workday, total sitting time or BMI. Conclusions These results indicate that social media use is associated with increased sitting time while using a computer, and total sitting time on non-workdays. So what? The rise in social media use may have a negative impact on health by contributing to computer sitting and total sitting time on non-workdays. Future longitudinal research with a representative sample and objective sitting measures is needed to confirm findings.
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Uijtdewilligen, Léonie; Yin, Jason Dean-Chen; van der Ploeg, Hidde P; Müller-Riemenschneider, Falk
2017-12-13
Evidence on the health risks of sitting is accumulating. However, research identifying factors influencing sitting time in adults is limited, especially in Asian populations. This study aimed to identify socio-demographic and lifestyle correlates of occupational, leisure and total sitting time in a sample of Singapore working adults. Data were collected between 2004 and 2010 from participants of the Singapore Multi Ethnic Cohort (MEC). Medical exclusion criteria for cohort participation were cancer, heart disease, stroke, renal failure and serious mental illness. Participants who were not working over the past 12 months and without data on sitting time were excluded from the analyses. Multivariable regression analyses were used to examine cross-sectional associations of self-reported age, gender, ethnicity, marital status, education, smoking, caloric intake and moderate-to-vigorous leisure time physical activity (LTPA) with self-reported occupational, leisure and total sitting time. Correlates were also studied separately for Chinese, Malays and Indians. The final sample comprised 9384 participants (54.8% male): 50.5% were Chinese, 24.0% Malay, and 25.5% Indian. For the total sample, mean occupational sitting time was 2.71 h/day, mean leisure sitting time was 2.77 h/day and mean total sitting time was 5.48 h/day. Sitting time in all domains was highest among Chinese. Age, gender, education, and caloric intake were associated with higher occupational sitting time, while ethnicity, marital status and smoking were associated with lower occupational sitting time. Marital status, smoking, caloric intake and LTPA were associated with higher leisure sitting time, while age, gender and ethnicity were associated with lower leisure sitting time. Gender, marital status, education, caloric intake and LTPA were associated with higher total sitting time, while ethnicity was associated with lower total sitting time. Stratified analyses revealed different associations within sitting domains for Indians compared to Chinese and Malays. Our findings highlight the need to focus on separate domains of sitting (occupational, leisure or total) when identifying which factors determine this behavior, and that the content of intervention programs should be tailored to domain-specific sitting rather than to sitting in general. Finally, our study showed ethnic differences and therefore we recommend to culturally target interventions.
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Kantor, R.; Thyssen, J. P.; Paller, A. S.; Silverberg, J. I.
2017-01-01
Background The lack of standardized nomenclature for atopic dermatitis (AD) creates unnecessary confusion for patients, healthcare providers, and researchers. It also negatively impacts accurate communication of research in the scientific literature. We sought to determine the most commonly used terms for AD. Methods A systematic review of the MEDLINE, EMBASE, and LILACS (1945–2016) for the terms AD, atopic eczema (AE), and multiple other eczematous disorders. Results In MEDLINE, 33 060 were identified, of which 21 299 (64.4%) publications used the term ‘AD’, 15 510 (46.9%) ‘eczema’, and only 2471 (7.5%) AE. Most of these publications used the term AD (82.0%) or eczema (70.8%) without additional nomenclature; only 1.2% used AE alone. Few publications used the terminology ‘childhood eczema’, ‘flexural eczema’, ‘infantile eczema’, ‘atopic neurodermatitis’, or ‘Besnier’s prurigo’. AD was rarely used until the late 1970s, after which it became the most commonly used of the three terms and continuously increased until 2015. Atopic eczema decreased between 2008 and 2015. Atopic dermatitis was the most commonly used term in studies across almost all publication types, languages, and journals. Conclusion Atopic dermatitis is the most commonly used term and appears to be increasing in popularity. Given that eczema is a nonspecific term that describes the morphological appearance of several forms of dermatitis, we strongly suggest the use of a more specific term, AD, in publications, healthcare clinician training, and patient education. Support from researchers, reviewers, and editors is key to success. PMID:27392131
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Kantor, R; Thyssen, J P; Paller, A S; Silverberg, J I
2016-10-01
The lack of standardized nomenclature for atopic dermatitis (AD) creates unnecessary confusion for patients, healthcare providers, and researchers. It also negatively impacts accurate communication of research in the scientific literature. We sought to determine the most commonly used terms for AD. A systematic review of the MEDLINE, EMBASE, and LILACS (1945-2016) for the terms AD, atopic eczema (AE), and multiple other eczematous disorders. In MEDLINE, 33 060 were identified, of which 21 299 (64.4%) publications used the term 'AD', 15 510 (46.9%) 'eczema', and only 2471 (7.5%) AE. Most of these publications used the term AD (82.0%) or eczema (70.8%) without additional nomenclature; only 1.2% used AE alone. Few publications used the terminology 'childhood eczema', 'flexural eczema', 'infantile eczema', 'atopic neurodermatitis', or 'Besnier's prurigo'. AD was rarely used until the late 1970s, after which it became the most commonly used of the three terms and continuously increased until 2015. Atopic eczema decreased between 2008 and 2015. Atopic dermatitis was the most commonly used term in studies across almost all publication types, languages, and journals. Atopic dermatitis is the most commonly used term and appears to be increasing in popularity. Given that eczema is a nonspecific term that describes the morphological appearance of several forms of dermatitis, we strongly suggest the use of a more specific term, AD, in publications, healthcare clinician training, and patient education. Support from researchers, reviewers, and editors is key to success. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Parents' reported preference scores for childhood atopic dermatitis disease states
Friedman, Joëlle Y; Reed, Shelby D; Weinfurt, Kevin P; Kahler, Kristijan H; Walter, Emmanuel B; Schulman, Kevin A
2004-01-01
Background We sought to elicit preference weights from parents for health states corresponding to children with various levels of severity of atopic dermatitis. We also evaluated the hypothesis that parents with children who had been diagnosed with atopic dermatitis would assign different preferences to the health state scenarios compared with parents who did not have a child with atopic dermatitis. Methods Subjects were parents of children aged 3 months to 18 years. The sample was derived from the General Panel, Mommies Sub-Panel, and Chronic Illness Sub-Panel of Harris Interactive. Participants rated health scenarios for atopic dermatitis, asthma, and eyeglasses on a visual analog scale, imagining a child was experiencing the described state. Results A total of 3539 parents completed the survey. Twenty-nine percent had a child with a history of atopic dermatitis. Mean preference scores for atopic dermatitis were as follows: mild, 91 (95% confidence interval [CI], 90.7 to 91.5); mild/moderate, 84 (95%CI, 83.5 to 84.4); moderate, 73 (95%CI, 72.5 to 73.6); moderate/severe, 61 (95%CI, 60.6 to 61.8); severe, 49 (95% CI, 48.7 to 50.1); asthma, 58 (95%CI, 57.4 to 58.8); and eyeglasses, 87(95%CI, 86.3 to 87.4). Conclusions Parents perceive that atopic dermatitis has a negative effect on quality of life that increases with disease severity. Estimates of parents' preferences can provide physicians with insight into the value that parents place on their children's treatment and can be used to evaluate new medical therapies for atopic dermatitis. PMID:15491500
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Mitchell, Amy E; Fraser, Jennifer A
2011-02-01
Support and education for parents faced with managing a child with atopic dermatitis is crucial to the success of current treatments. Interventions aiming to improve parent management of this condition are promising. Unfortunately, evaluation is hampered by lack of precise research tools to measure change. To develop a suite of valid and reliable research instruments to appraise parents' self-efficacy for performing atopic dermatitis management tasks; outcome expectations of performing management tasks; and self-reported task performance in a community sample of parents of children with atopic dermatitis. The Parents' Eczema Management Scale (PEMS) and the Parents' Outcome Expectations of Eczema Management Scale (POEEMS) were developed from an existing self-efficacy scale, the Parental Self-Efficacy with Eczema Care Index (PASECI). Each scale was presented in a single self-administered questionnaire, to measure self-efficacy, outcome expectations, and self-reported task performance related to managing child atopic dermatitis. Each was tested with a community sample of parents of children with atopic dermatitis, and psychometric evaluation of the scales' reliability and validity was conducted. A community-based convenience sample of 120 parents of children with atopic dermatitis completed the self-administered questionnaire. Participants were recruited through schools across Australia. Satisfactory internal consistency and test-retest reliability was demonstrated for all three scales. Construct validity was satisfactory, with positive relationships between self-efficacy for managing atopic dermatitis and general perceived self-efficacy; self-efficacy for managing atopic dermatitis and self-reported task performance; and self-efficacy for managing atopic dermatitis and outcome expectations. Factor analyses revealed two-factor structures for PEMS and PASECI alike, with both scales containing factors related to performing routine management tasks, and managing the child's symptoms and behaviour. Factor analysis was also applied to POEEMS resulting in a three-factor structure. Factors relating to independent management of atopic dermatitis by the parent, involving healthcare professionals in management, and involving the child in the management of atopic dermatitis were found. Parents' self-efficacy and outcome expectations had a significant influence on self-reported task performance. Findings suggest that PEMS and POEEMS are valid and reliable instruments worthy of further psychometric evaluation. Likewise, validity and reliability of PASECI was confirmed. Copyright © 2010 Elsevier Ltd. All rights reserved.
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Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.
Brunner, Patrick M; Silverberg, Jonathan I; Guttman-Yassky, Emma; Paller, Amy S; Kabashima, Kenji; Amagai, Masayuki; Luger, Thomas A; Deleuran, Mette; Werfel, Thomas; Eyerich, Kilian; Stingl, Georg
2017-01-01
Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies. Given the possibility of atopic dermatitis-related systemic immune activation, future investigations of new interventions should concurrently examine the impact on these comorbidities. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
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Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis.
Nousbeck, Janna; Irvine, Alan D
2016-12-01
In complex disease such as atopic dermatitis, the journey from identification of strong risk loci to profound functional and mechanistic insights can take several years. Here, Manz et al. have elegantly deciphered the mechanistic pathways in the well-established 11q13.5 atopic dermatitis risk locus. Their genetic and functional insights emphasize a role for T regulatory cells in atopic dermatitis pathogenesis. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
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Plasma and skin vitamin E concentrations in canine atopic dermatitis.
Plevnik Kapun, Alja; Salobir, Janez; Levart, Alenka; Tavčar Kalcher, Gabrijela; Nemec Svete, Alenka; Kotnik, Tina
2013-01-01
Altered homeostasis of vitamin E has been demonstrated in human atopic dermatitis. Data on plasma and skin vitamin E concentrations in canine atopic dermatitis (CAD) are not available. To determine vitamin E concentrations in plasma and skin of atopic dogs. Vitamin E concentrations in plasma and full-thickness skin biopsies of 15 atopic dogs were related to CAD extent and severity index (CADESI-03) scores and compared to the equivalent concentrations in 17 healthy dogs. Statistically significant differences of measured parameters between the two groups were determined by the nonparametric Mann Whitney U test and correlations between CADESI-03 scores and vitamin E concentrations were evaluated by the Spearman rank test. A value of P < 0.05 was considered significant. Plasma concentrations of vitamin E were significantly lower in atopic dogs than in healthy dogs, with median values of 29.8 and 52.9 μmol/L, respectively. Skin vitamin E values did not differ significantly between patients and healthy controls. The median concentration of skin vitamin E in atopic dogs was higher than that in healthy dogs. No significant correlations were found between CADESI-03 score and plasma vitamin E or skin vitamin E concentrations. Significantly lower plasma vitamin E concentrations in atopic dogs than in healthy controls indicate altered homeostasis of vitamin E in CAD. Further investigation into vitamin E supplementation in CAD is warranted.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Lu, Junxia; Burton, Sarah D.; Xu, Yimin
2014-07-11
Leucine-Rich Amelogenin Protein (LRAP) is a member of the amelogenin family of biomineralization proteins, proteins which play a critical role in enamel formation. Recent studies have revealed the structure and orientation of the N- and C-terminus of LRAP bound to hydroxyapatite (HAP), a surface used as an analog of enamel. The structure of one region, K24 to S28, was found to be sensitive to phosphorylation of S16, the only naturally observed site of serine phosphorylation in LRAP, suggesting that the residues from K24 to S28 may sit at a key region of structural flexibility and play a role in themore » protein’s function. In this work, we investigated the sensitivity of the structure and orientation of this region when bound to HAP as a function of several factors which may vary during enamel formation to influence structure: the ionic strength (0.05 M, 0.15 M, 0.2 M), the calcium concentration (0.07 mM and 0.4 mM), and the surface to which it is binding (HAP and carbonated apatite (CAP), a more direct mimic of enamel). A naturally occurring mutation found in amelogenin (T21I), was also investigated. The structure in the K24S28 region of the protein was found to be sensitive to these conditions, with the CAP surface and excess Ca2+ (8:1 [Ca2+]:[LRAP-K24S28(+P)]) resulting in a much tighter helix, while low ionic strength relaxed the helical structure. Higher ionic strength and the point mutation did not result in any structural change in this region. The distance of the backbone of K24 from the surface was most sensitive to excess Ca2+ and in the T21I-mutation. Collectively, these data suggest that the protein is able to accommodate structural changes while maintaining its interaction with the surface, and provides further evidence of the structural sensitivity of the K24 to S28 region, a sensitivity that may contribute to function in biomineralization. This research was supported by NIH-NIDCR Grant DE-015347. The research was performed at the Pacific Northwest National Laboratory (PNNL), a facility operated by Battelle for the U.S. Department of Energy.« less
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Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease.
Smart, J M; Kemp, A S
2002-05-01
Polyclonal cytokine responses following stimulation of T cells with mitogens or superantigens provides information on cytokine production from a wide range of T cells. Alternatively allergen-induced T cell responses can provide information on cytokine production by allergen-reactive T cells. While there is evidence of increased Th2 and reduced Th1 cytokine production following T cell stimulation with non-specific mitogens and superantigens, the evidence that Th1 cytokine production to allergens is decreased in line with a postulated imbalance in Th1/Th2 responses is unclear, with studies finding decreased, no difference or increased IFN-gamma responses to allergens in atopic subjects. To examine childhood polyclonal and allergen-induced cytokine responses in parallel to evaluate cytokine imbalances in childhood atopic disease. PBMC cytokine responses were examined in response to a polyclonal stimulus, staphylococcal superantigen (SEB), in parallel with two inhalant allergens, house dust mite (HDM) and rye grass pollen (RYE), and an ingested allergen, ovalbumin (OVA), in (a) 35 healthy children (non-atopic) and (b) 36 children with atopic disease (asthma, eczema and/or rhinitis) (atopic). Atopic children had significantly reduced IFN-gamma and increased IL-4 and IL-5 but not IL13 production to SEB superantigen stimulation when compared with non-atopic children. HDM and RYE allergens stimulated significantly increased IFN-gamma, IL-5 and IL-13, while OVA stimulated significantly increased IFN-gamma production in atopic children. We show that a polyclonal stimulus induces a reduced Th1 (IFN-gamma) and increased Th2 (IL-4 and IL-5) cytokine pattern. In contrast, the allergen-induced cytokine responses in atopic children were associated with both increased Th1 (INF-gamma) and Th2 (IL-5 and IL-13) cytokine production. The increased Th1 response to allergen is likely to reflect prior sensitization and indicates that increases in both Th1 and Th2 cytokine production to allergens exists concomitantly with a decreased Th1 response to a polyclonal stimulus in atopic children.
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Gupta, Nidhi; Christiansen, Caroline Stordal; Hanisch, Christiana; Bay, Hans; Burr, Hermann; Holtermann, Andreas
2017-01-01
Objectives To investigate the differences between a questionnaire-based and accelerometer-based sitting time, and develop a model for improving the accuracy of questionnaire-based sitting time for predicting accelerometer-based sitting time. Methods 183 workers in a cross-sectional study reported sitting time per day using a single question during the measurement period, and wore 2 Actigraph GT3X+ accelerometers on the thigh and trunk for 1–4 working days to determine their actual sitting time per day using the validated Acti4 software. Least squares regression models were fitted with questionnaire-based siting time and other self-reported predictors to predict accelerometer-based sitting time. Results Questionnaire-based and accelerometer-based average sitting times were ≈272 and ≈476 min/day, respectively. A low Pearson correlation (r=0.32), high mean bias (204.1 min) and wide limits of agreement (549.8 to −139.7 min) between questionnaire-based and accelerometer-based sitting time were found. The prediction model based on questionnaire-based sitting explained 10% of the variance in accelerometer-based sitting time. Inclusion of 9 self-reported predictors in the model increased the explained variance to 41%, with 10% optimism using a resampling bootstrap validation. Based on a split validation analysis, the developed prediction model on ≈75% of the workers (n=132) reduced the mean and the SD of the difference between questionnaire-based and accelerometer-based sitting time by 64% and 42%, respectively, in the remaining 25% of the workers. Conclusions This study indicates that questionnaire-based sitting time has low validity and that a prediction model can be one solution to materially improve the precision of questionnaire-based sitting time. PMID:28093433
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Li, Ingrid; Mackey, Martin G; Foley, Bridget; Pappas, Evangelos; Edwards, Kate; Chau, Josephine Y; Engelen, Lina; Voukelatos, Alexander; Whelan, Anna; Bauman, Adrian; Winkler, Elisabeth; Stamatakis, Emmanuel
2017-06-01
To examine the effects of different sit-stand protocols on work-time sitting and physical activity (PA) of office workers. Participants (n = 26, 77% women, mean age 42) were randomly allocated to usual sitting (control) or one of three sit-stand protocols (intervention) facilitated by height-adjustable workstations for a 4-week period between June and August 2015. Sitting, standing, and stepping time were assessed by inclinometry (activPAL); leisure-time physical activity (LTPA) by self-report. One-way analysis of covariance (ANCOVA) and post-hoc (Bonferroni) tests explored between-group differences. Compared with baseline, intervention groups reduced work sitting time by 113 minutes/8-hour workday (95% confidence interval [CI] [-147,-79]) and increased work standing time by 96 minutes/8-hour workday (95% CI [67,125]) without significantly impacting LTPA/sleep time. Sit-stand protocols facilitated by height-adjustable workstations appear to reduce office workers' sitting time without significant adverse effects on LTPA.
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Structural evolution of calcite at high temperatures: Phase V unveiled
Ishizawa, Nobuo; Setoguchi, Hayato; Yanagisawa, Kazumichi
2013-01-01
The calcite form of calcium carbonate CaCO3 undergoes a reversible phase transition between Rc and Rm at ~1240 K under a CO2 atmosphere of ~0.4 MPa. The joint probability density function obtained from the single-crystal X-ray diffraction data revealed that the oxygen triangles of the CO3 group in the high temperature form (Phase V) do not sit still at specified positions in the space group Rm, but migrate along the undulated circular orbital about carbon. The present study also shows how the room temperature form (Phase I) develops into Phase V through an intermediate form (Phase IV) in the temperature range between ~985 K and ~1240 K. PMID:24084871
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Gahr, N; Fölster-Holst, R; Weichenthal, M; Christophers, E; Schröder, J-M; Bartels, J
2011-03-01
The presence of eosinophils and/or eosinophil-derived products in the dermis is characteristic for involved skin of patients with atopic dermatitis and contributes to the observed tissue injury. CCL11 is a potent chemoattractant and activator of human eosinophils and interleukin (IL)-4 is a potent inducer of CCL11 expression in dermal fibroblasts. As increased fibroblast CCL11 expression may explain eosinophilic infiltration of involved skin areas in atopic dermatitis, we asked whether dermal fibroblasts from atopic patients differ from fibroblasts of healthy individuals in their ability to express CCL11. We compared IL-4-induced CCL11 mRNA expression using reverse transcription-polymerase chain reaction from cultured dermal fibroblasts derived from biopsies of chronic lesional and acute lesional atopic skin as well as from skin biopsies derived from normal skin of healthy donors. Considerable variability in IL-4-induced relative CCL11 mRNA expression was detected in fibroblasts derived from biopsies of different individuals. The lowest median IL-4 concentration inducing half maximal CCL11 mRNA expression (EC(50)) was found in fibroblasts derived from acute inflamed atopic lesions. Inducibility of CCL11 in dermal fibroblasts upon stimulation with Th2 cytokines explains the tissue eosinophilia observed in the presence of Th2 cytokines and the localization of eosinophils to the dermis. Decreased EC(50) values of IL-4-induced CCL11 expression in fibroblasts from acute inflamed atopic skin lesions indicates increased IL-4 responsiveness in these lesions and further substantiates the special role for IL-4-induced dermal fibroblast CCL11 expression in acute lesions. Variable CCL11 expression in fibroblasts from different patients with atopic dermatitis indicates heterogeneity of factors determining atopic phenotype in atopic dermatitis. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.
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Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
Simpson, Eric L.; Chalmers, Joanne R.; Hanifin, Jon M.; Thomas, Kim S.; Cork, Michael J.; McLean, W.H. Irwin; Brown, Sara J.; Chen, Zunqiu; Chen, Yiyi; Williams, Hywel C.
2014-01-01
Background Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and is increasing in prevalence. Because of the significant socioeconomic effect of atopic dermatitis and its effect on the quality of life of children and families, there have been decades of research focused on disease prevention, with limited success. Recent advances in cutaneous biology suggest skin barrier defects might be key initiators of atopic dermatitis and possibly allergic sensitization. Objective Our objective was to test whether skin barrier enhancement from birth represents a feasible strategy for reducing the incidence of atopic dermatitis in high-risk neonates. Methods We performed a randomized controlled trial in the United States and United Kingdom of 124 neonates at high risk for atopic dermatitis. Parents in the intervention arm were instructed to apply full-body emollient therapy at least once per day starting within 3 weeks of birth. Parents in the control arm were asked to use no emollients. The primary feasibility outcome was the percentage of families willing to be randomized. The primary clinical outcome was the cumulative incidence of atopic dermatitis at 6 months, as assessed by a trained investigator. Results Forty-two percent of eligible families agreed to be randomized into the trial. All participating families in the intervention arm found the intervention acceptable. A statistically significant protective effect was found with the use of daily emollient on the cumulative incidence of atopic dermatitis with a relative risk reduction of 50% (relative risk, 0.50; 95% CI, 0.28-0.9; P = .017). There were no emollient-related adverse events and no differences in adverse events between groups. Conclusion The results of this trial demonstrate that emollient therapy from birth represents a feasible, safe, and effective approach for atopic dermatitis prevention. If confirmed in larger trials, emollient therapy from birth would be a simple and low-cost intervention that could reduce the global burden of allergic diseases. PMID:25282563
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Bähr, Melanie; Fechner, Anita; Kaatz, Martin; Jahreis, Gerhard
2014-01-01
The increasing use of lupin in food processing poses a problem of potential (cross-)allergic reactions. To evaluate the prevalence of sensitization to lupin in comparison to that of other legumes skin prick tests were performed with lupin, pea, peanut, and soybean in atopic (n = 81) and non-atopic (n = 102) German adults. Of these 183 subjects, 20 subjects had to be excluded due to invalid skin prick tests (reaction to histamine <3 mm or to sodium chloride >2 mm). Thus, skin prick tests of 163 subjects were included in final analyses. Of 163 subjects, 18 had a positive reaction to at least one legume tested. Overall skin prick test reactivity was different among non-atopic and atopic subjects (P = 0.005). Altogether, six subjects (4%) were sensitized to lupin, 12 (7%) to pea, 5 (3%) to peanut, and 8 (5%) to soybean. Two (2%) of the 92 non-atopic subjects and 4 (6%) of the 71 atopic subjects had a positive skin prick test to lupin. Of the 6 subjects sensitized to lupin, 3 (50%) were also sensitized to pea, 3 (50%) to peanut, and 5 (83%) to soybean. In conclusion, the prevalence rates of lupin sensitization were comparable to or even lower than those of pea, peanut, and soybean. To date, lupin allergy is suspected to be relatively uncommon in the overall German population since lupin sensitization occurred in only 2% of non-atopic subjects. However, there is a clear risk of a lupin allergy in predisposed subjects, since the frequency of lupin sensitization was 6% in atopic subjects. In particular, subjects with existing sensitization or allergy to other legumes are at higher risk for a sensitization or allergy to lupin due to cross-reactivity. PMID:25400931
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Immediate effects of dynamic sitting exercise on the lower back mobility of sedentary young adults
Chatchawan, Uraiwan; Jupamatangb, Unthika; Chanchitc, Sunisa; Puntumetakul, Rungthip; Donpunha, Wanida; Yamauchi, Junichiro
2015-01-01
[Purpose] The aim of this study was to investigate the effects of dynamic sitting exercises during prolonged sitting on the lower back mobility of sedentary young adults. [Subjects and Methods] Seventy-one subjects aged between 18–25 years participated in this study. Following a randomized crossover study design, subjects were randomly assigned to two groups: sitting only and dynamic sitting exercise. The dynamic sitting exercise was a combination of lower back hyperextension and abdominal drawing-in movements which were repeated 6 times in a 1-minute period and performed every 20 minutes during a 2-hour sitting session. Lumbar range of movement was measured with the modified-modified Schober test, and the pain intensity was evaluated using the visual analog scale. [Results] After the experiment, the lumbar range of movement was significantly impaired in the sitting only group; however, it was significantly improved in the dynamic sitting exercise group. There were significant differences in lumbar range of movement of both flexion and extension between the groups. No significant difference in pain intensity between the groups was found. [Conclusion] These results suggest that dynamic sitting exercises during prolonged sitting can prevent decreases in lumbar range of movement in both back flexion and extension following a 2-hour sitting period. PMID:26696698
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Allmond, James M; Stuchberry, A. E.; Danchev, M.
Radioactive 136Te has two valence protons and two valence neutrons outside of the 132Sn double shell closure, providing a simple laboratory for exploring the emergence of collectivity and nucleon- nucleon interactions. Coulomb excitation of 136Te on a titanium target was utilized to determine an extensive set of electromagnetic moments for the three lowest-lying states, including B(E2;0more » $$+\\atop{1}$$→ 2$$+\\atop{1}$$ ), Q(2$$+\\atop{1}$$ ), and g(2$$+\\atop{1}$$ ). The results indicate that the first-excited state, 2$$+\\atop{1}$$ , composed of the simple 2p ⊕ 2n system, is prolate deformed, and its wave function is dominated by neutron degrees of freedom, but not to the extent previously suggested. It is demonstrated that extreme sensitivity of g(2$$+\\atop{1}$$) to the proton and neutron contributions to the wave function provides unique insight into the nature of emerging collectivity, and g(2$$+\\atop{1}$$ ) was used to differentiate among several state-of-the-art theoretical calculations. Finally, our results are best described by the most recent shell model calculations.« less
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Allmond, James M; Stuchberry, A. E.; Danchev, M.; ...
2017-03-03
Radioactive 136Te has two valence protons and two valence neutrons outside of the 132Sn double shell closure, providing a simple laboratory for exploring the emergence of collectivity and nucleon- nucleon interactions. Coulomb excitation of 136Te on a titanium target was utilized to determine an extensive set of electromagnetic moments for the three lowest-lying states, including B(E2;0more » $$+\\atop{1}$$→ 2$$+\\atop{1}$$ ), Q(2$$+\\atop{1}$$ ), and g(2$$+\\atop{1}$$ ). The results indicate that the first-excited state, 2$$+\\atop{1}$$ , composed of the simple 2p ⊕ 2n system, is prolate deformed, and its wave function is dominated by neutron degrees of freedom, but not to the extent previously suggested. It is demonstrated that extreme sensitivity of g(2$$+\\atop{1}$$) to the proton and neutron contributions to the wave function provides unique insight into the nature of emerging collectivity, and g(2$$+\\atop{1}$$ ) was used to differentiate among several state-of-the-art theoretical calculations. Finally, our results are best described by the most recent shell model calculations.« less
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[Role of IgE-dependent reactions in atopic dermatitis].
Dynowski, Jarosław; Wasowska-Królikowska, Krystyna; Modzelewska-Hołyńska, Małgorzata; Tomaszewska, Monika; Funkowicz, Marzena
2007-01-01
Atopic dermatitis is a disease of multifactorial pathogenesis. of the study was to establish the most common allergens responsible for development of atopic symptoms in children with atopic dermatitis. the study complied 36 children aged 4 months - 3 years treated in the Department of Children Allergology, Gastroenterology and Nutrition because of atopic dermatitis. With each case the patient and family history of atopy was collected and basic laboratory tests were conducted (including total IgE and specific IgE using Polly Check system). eosinophilia was found in 11/36 children, elevated total IgE level in 16/36 and specific IgE were present in 14/36 patients. 6 patients proved to have sIgE for more then one allergen. The most commonly found allergens were animal hair, and food allergens. In 22 cases in spite of obvious clinical symptoms requiring therapy at hospital, all sIgE were negative for all tested allergens. although estimating sIgE is commonly used in diagnosing atopic dermatitis, it may not be sufficient to establish complete diagnosis. It seems that animal hair and food allergens are mainly responsible for development of atopic dermatitis.
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Atopy as a risk factor for subclinical hypothyroidism development in children.
Pedullà, Marcella; Umano, Giuseppina Rosaria; Fierro, Vincenzo; Capuano, Francesco; Di Sessa, Anna; Marzuillo, Pierluigi; Perrone, Laura; Del Giudice, Emanuele Miraglia
2017-08-28
Increased thyroid stimulating hormone (TSH) serum concentration can be a marker of subclinical hypothyroidism (SCH) or transient hyperthyrotropinemia. The aim of our study was to evaluate whether high serum TSH concentrations in allergic children could represent true SCH or isolated and transient hyperthyrotropinemia. We enrolled 620 allergic children (1.11-12.8 years) consecutively attending to our department. They were classified as atopics and non-atopics on the basis of the atopy work-up and, at baseline, they were investigated for thyroid function and low-grade inflammation state. Further, TSH was evaluated after 6 (T1) and 12 (T2) months. Both atopics and non-atopics showed higher SCH prevalence compared to controls (p=0.0055 and p=0.02, respectively), and a significant association between atopy and SCH (OR 10.11, 95% CI 1.36-75.12) was found. Both at T1 and T2, atopics had a significant risk of developing severe SCH compared to non-atopics (RR 1.8, 95% CI 1.39-2.34 and 1.61, 95% CI 1.21-2.14; respectively). Our data may suggest that hyperthyrotropinemia in atopic children could be used as a marker of true SCH.
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Atopic Eczema and Stress among Single Parents and Families: An Empirical Study of 96 Mothers.
Gieler, Uwe; Schoof, Stefanie; Gieler, Tanja; Scheewe, Sibylle; Schut, Christina; Kupfer, Jörg
2017-01-04
This study investigated the extent to which single mothers of children with atopic eczema experience disease-related stress. A total of 96 mothers were divided into 4 groups: mothers living with a partner, who had or did not have a child with atopic eczema, and single mothers, who had or did not have a child with atopic eczema. The following questionnaires were used to assess psychological burden: Short Stress Questionnaire (Kurzer Fragebogen zur Erfassung von Belastung; KFB), Satisfaction with Life Questionnaire (Fragebogen zur Lebenszufriedenheit; FLZ), General Depression Scale (Allgemeine Depressions-Skala; ADS), and the Questionnaire for Parents of Children with Atopic Eczema (Fragebogen für Eltern von Neurodermitis kranken Kindern; FEN). Single mothers had higher levels of helplessness and aggression due to their child's scratching behaviour than did mothers living with a partner and a child with atopic eczema. Single mothers of children with atopic eczema had the highest scores regarding experienced stress in the family and the lowest scores concerning general life satisfaction. Special care should be provided for single mothers with higher stress, in order to teach them how to deal with the scratching behaviour of their children.
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Saidj, Madina; Jørgensen, Torben; Jacobsen, Rikke K; Linneberg, Allan; Aadahl, Mette
2013-01-01
The workplace is a main setting for prolonged sitting for some occupational groups. Convincing evidence has recently accumulated on the detrimental cardio-metabolic health effects of leisure-time sitting. Yet, much less is known about occupational sitting, and the potential health risk attached compared to leisure-time sitting. To explore the separate and joint associations of occupational and leisure-time sitting with cardio-metabolic risk factors in working adults. All working adults (N = 2544) from the Health2006, a Danish population-based study, were included in this cross-sectional study. Participants reported hours of sitting during work, during leisure-time along with socio-demographic and behavioral characteristics, including physical activity. Cardio-metabolic risk factors (waist circumference, body mass index, body fat percentage, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, insulin, hemoglobin A1c and plasma glucose) were measured. Associations were explored by linear regression for leisure-time, occupational, and overall sitting time. Statistically significant (p<.05) detrimental associations of leisure-time sitting were observed with all cardio-metabolic risk factors, except hemoglobin A1c and plasma glucose. Similarly, occupational sitting time was significantly detrimentally associated with HDL cholesterol, triglycerides, and insulin. For categories of sitting time, a joint adverse association of sitting much during both work-time and leisure-time was observed. The associations of occupational sitting time with cardio-metabolic risk factors were fewer and weaker compared to leisure-time sitting. Yet, the joint associations of occupational and leisure-time sitting with cardio-metabolic risk factors were higher than the separate. Our findings amplify the need for further focus in this area prior to making assumptions about equivalent health risks across sedentary behaviors. To our knowledge, this is the first study to contrast the deleterious associations of prolonged occupational and leisure-time sitting, both separately and jointly.
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Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction.
Morishima, Takuma; Restaino, Robert M; Walsh, Lauren K; Kanaley, Jill A; Padilla, Jaume
2017-06-01
We have previously shown that local heating or leg fidgeting can prevent prolonged sitting-induced leg endothelial dysfunction. However, whether physical activity prevents subsequent sitting-induced leg endothelial dysfunction remains unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by prior exercise. We also examined if, in the absence of exercise, standing is an effective alternative strategy to sitting for conserving leg endothelial function. Fifteen young healthy subjects completed three randomized experimental trials: (1) sitting without prior exercise; (2) sitting with prior exercise; and (3) standing without prior exercise. Following baseline popliteal artery flow-mediated dilation (FMD) measurements, subjects maintained a supine position for 45 min in the sitting and standing trials, without prior exercise, or performed 45 min of leg cycling before sitting (i.e. sitting with prior exercise trial). Thereafter, subjects were positioned into a seated or standing position, according to the trial, for 3 h. Popliteal artery FMD measures were then repeated. Three hours of sitting without prior exercise caused a significant impairment in popliteal artery FMD (baseline: 3.8±0.5%, post-sitting: 1.5±0.5%, P <0.05), which was prevented when sitting was preceded by a bout of cycling exercise (baseline: 3.8±0.5%, post-sitting: 3.6±0.7%, P >0.05). Three hours of standing did not significantly alter popliteal artery FMD (baseline: 4.1±0.4%, post-standing: 4.3±0.4%, P >0.05). In conclusion, prolonged sitting-induced leg endothelial dysfunction can be prevented by prior aerobic exercise. In addition, in the absence of exercise, standing represents an effective substitute to sitting for preserving leg conduit artery endothelial function. © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
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O'Sullivan, Peter B; Smith, Anne J; Beales, Darren J; Straker, Leon M
2011-04-01
Conflicting evidence exists regarding relationships among sitting posture, factors that influence sitting posture, and back pain. This conflicting evidence may partially be due to the presence of multiple and overlapping factors associated with both sitting posture and back pain. The purpose of this study was to determine whether the degree of slump in sitting was associated with sex and other physical, lifestyle, or psychosocial factors. Additionally, the relationship between the report of back pain made worse by sitting and the degree of slump in sitting and other physical, lifestyle, or psychosocial factors was investigated. This was a cross-sectional study. Adolescents (n=1,596) completed questionnaires to determine lifestyle and psychosocial profiles and the experience of back pain. Sagittal sitting posture, body mass index (BMI), and back muscle endurance (BME) were recorded. Standing posture subgroup categorization was determined. Multivariate analysis revealed that the most significant factor associated with the degree of slump in sitting was male sex, followed by non-neutral standing postures, lower perceived self-efficacy, lower BME, greater television use, and higher BMI. Multivariable analysis indicated poorer Child Behaviour Checklist scores were the strongest correlate of report of back pain made worse by sitting, whereas degree of slump in sitting, female sex, and BME were more weakly related. Causality cannot be determined from this cross-sectional study, and 60% of sitting posture variation was not explained by the measured variables. Slump in sitting was associated with physical correlates, as well as sex, lifestyle, and psychosocial factors, highlighting the complex, multidimensional nature of usual sitting posture in adolescents. Additionally, this study demonstrated that a greater degree of slump in sitting was only weakly associated with adolescent back pain made worse by sitting after adjustment for other physical and psychosocial factors.
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Advances in understanding and managing atopic dermatitis
Barton, Michael; Sidbury, Robert
2015-01-01
Atopic dermatitis is a chronic, pruritic skin disease characterized by an improperly functioning skin barrier and immune dysregulation. We review proposed atopic dermatitis pathomechanisms, emphasizing how these impact current perspectives on natural history, role of allergic sensitization, and future therapeutic targets. PMID:26918129
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Canine and Human Atopic Dermatitis: Two Faces of the Same Host-Microbe Interaction.
Santoro, Domenico; Rodrigues Hoffmann, Aline
2016-06-01
Host-microbe interaction has been suggested to play a critical role in the pathogenesis of atopic dermatitis. The dog has been shown to be the best model to study both pathogenesis and microbiome modifications in atopic dermatitis. Bradley et al. show a significant correlation between microbiome diversity, clinical signs, and skin barrier function in atopic dogs before, during, and after antimicrobial therapy. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
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Current management of atopic dermatitis and interruption of the atopic march.
Boguniewicz, Mark; Eichenfield, Lawrence F; Hultsch, Thomas
2003-12-01
Treatment of atopic dermatitis requires a comprehensive approach that includes evaluation of potential triggers and education of the patient and family regarding proper avoidance measures. Hydration of the skin and maintenance of an intact skin barrier remain integral to proper management. Although topical corticosteroids have been a mainstay of anti-inflammatory therapy, the newer topical calcineurin inhibitors offer advantages for treatment of this chronic, relapsing disease. Studies aimed at defining optimal combination therapy and early intervention might change the treatment paradigm for atopic dermatitis.
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[Atopic dermatitis in children: general principles of management].
Takeuchi, Yusuke Leo; Christen-Zaech, Stéphanie
2013-04-03
Atopic dermatitis is the most frequent dermatosis in childhood. Numerous studies underscored the central role of skin barrier alterations in the pathogenesis of the inflammatory skin lesions. The management of atopic dermatitis has to be multidimensional. It combines among others some daily local care and a sporadic topical anti-inflammatory treatment during the acute flare-ups. The objective of this article is to summarize, in light of the recent European guidelines, the general principles of management of atopic dermatitis, for the general practitioner.
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Gaballah, Hanaa H; Gaber, Rasha A; Sharshar, Ragia S; Elshweikh, Samah A
2018-06-20
Allergic asthma is a chronically relapsing inflammatory airway disease with a complex pathophysiology. This study was undertaken to investigate the potential contribution of NOD2 signaling, proinflammatory cytokines, chitotriosidase (CHIT1) activity, oxidative stress and DNA damage to atopic asthma pathogenesis, as well as to explore their possible role as surrogate noninvasive biomarkers for monitoring asthma severity. Sixty patients with atopic bronchial asthma who were divided according to asthma severity into 40 mild-moderate, 20 severe atopic asthmatics, in addition to thirty age-matched healthy controls were enrolled in this study. NOD2 expression in PBMCs was assessed by quantitative real-time RT-PCR. DNA damage indices were assessed by alkaline comet assay. Serum IgE, IL-17, IL-8 and 3-Nitrotyrosine levels were estimated by ELISA. Serum CHIT1and GST activities, as well as MDA levels, were measured. NOD2 mRNA relative expression levels were significantly decreased in atopic asthmatic cases relative to controls with lower values among severe atopic asthmatics. On the other hand, IL-17 and IL-8 serum levels, CHIT1 activity, DNA damage indices and oxidative stress markers were significantly increased in atopic asthmatic cases relative to controls with higher values among severe atopic asthmatics. The change in these parameters correlated significantly with the degree of decline in lung function. The interplay between NOD2 signaling, proinflammatory cytokines, CHIT1 activity, heightened oxidative stress and DNA damage orchestrates allergic airway inflammation and thus contributing to the pathogenesis of atopic asthma. These parameters qualified for measurement as part of new noninvasive biomarker panels for monitoring asthma severity. Copyright © 2018 Elsevier B.V. All rights reserved.
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Batlles Garrido, J; Torres-Borrego, J; Bonillo Perales, A; Rubí Ruiz, T; González Jiménez, Y; Momblán De Cabo, J; Aguirre Rodríguez, J; Jiménez Liria, R; Losilla Maldonado, A; Daza Torres, M
2010-01-01
Atopic eczema affects 5-10% of the Spanish paediatric population, and has increased in frequency over the last few decades, probably due to changes in the environment and lifestyle. Phase II of the ISAAC (International Study of Asthma and Allergies in Childhood) uses a standardised methodology to establish the prevalence of allergic disorders and factors linked to them in each centre. To assess the prevalence and severity of atopic eczema, and to establish factors linked to atopic eczema in 10-11 year-old school children in the city of Almeria (South-East coast of Spain). An ecological study was carried out as part of ISAAC II, using homologated questionnaires and allergic tests in 1143 schoolchildren. Statistic association was assessed by means of chi(2) test, and then logistic regression analysis was performed with the most significant variables from the univariant analysis. The prevalence of atopic eczema was 11.4%. The risk factors found in the multiple logistic regression analysis were: personal antecedents of severe asthma (OR 19 CI 95% 1.35-266) and severe rhinitis (OR 7.7 CI 95% 1.79-33), fungi in bedroom during the first year of life (OR 4.2 CI 95% 1.17-15.1) and atopic eczema in one parent (OR 5.2 CI 95% 2.69-10.1). The prevalence of atopic eczema is similar to that found in other studies within ISAAC Phase I. The most important risk factors for atopic eczema are family and personal history of other atopic diseases and the presence of fungi in the home. Copyright 2009 SEICAP. Published by Elsevier Espana. All rights reserved.
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Nybacka, S; Öhman, L; Störsrud, S; Mybeck, M; Böhn, L; Wilpart, K; Winkvist, A; Bengtsson, U; Törnblom, H; Simrén, M
2018-06-01
Among patients with irritable bowel syndrome (IBS), atopic disease has been proposed as a common comorbidity increasing the IBS symptom burden. We therefore assessed the prevalence of self-reported atopy among patients with IBS as compared to non-IBS controls, and whether atopy and higher serum IgE levels were associated with increased IBS symptom severity. Levels of total and specific IgE in serum were measured and questionnaires assessing the presence of atopic disease (ie, eczema, asthma, rhinoconjunctivitis, and pollen allergy), gastrointestinal symptom burden, food intolerance, somatic, and psychological symptoms were completed. In total, 223 patients with IBS and 47 controls participated. Presence of atopic disease was reported in 55% of patients with IBS compared to 40% of controls (P = .07). IBS patients with atopic manifestations (N = 123) had higher total serum IgE levels (median 31 vs 16 kU A /L, P < .001) and higher prevalence of self-reported food intolerance (28% vs 9%, P = .002) than non-atopic IBS patients (N = 100), respectively, but no major difference in gastrointestinal or psychological symptom burden was noted. However, severe somatic symptoms were more common among atopic than non-atopic patients with IBS (38% vs 27%, P = .028). We found no associations between self-reported atopy and IBS symptom severity using linear regression models. Atopic disease is common in patients with IBS, but that is also true for subjects without IBS. The presence of atopic disease in IBS is associated with self-reported food intolerance and somatic symptom severity, but unrelated to IBS symptom severity. © 2018 John Wiley & Sons Ltd.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Brodsky, Stanley J.; Lebed, Richard F.; Lyubovitskij, Valery E.
We study the exclusive double-photon annihilation processes, e +e - →γγ* → γV 0 and e +e - γ*γ* Vmore » $$0\\atop{a}$$V$$0\\atop{b}$$, where the V$$0\\atop{i}$$ is a neutral vector meson produced in the forward kinematical region: s>> -t and -t >> Λ$$2\\atop{QCD}$$. We show how the differential cross sections $$dσ\\atop{dt}$$, as predicted by QCD, have additional falloff in the momentum transfer squared t due to the QCD compositeness of the hadrons, consistent with the leading-twist fixed-θ CM scaling laws, both in terms of conventional Feynman diagrams and by using the AdS/QCD holographic model to obtain the results more transparently. However, even though they are exclusive channels and not associated with the conventional electron–positron annihilation process e +e -→γ*→ $$q\\bar{q}$$, these total cross sections σ(e +e -→γV 0)and σ(e +e -→V$$0\\atop{a}$$V$$0\\atop{b}$$), integrated over the dominant forward-and backward-θ CM angular domains, scale as 1/s, and thus contribute to the leading-twist scaling behavior of the ratio R e+e-. We generalize these results to exclusive double-electroweak vector-boson annihilation processes accompanied by the forward production of hadrons, such as e +e -→Z 0V 0and e +e -→W -ρ +. These results can also be applied to the exclusive production of exotic hadrons such as tetraquarks, where the cross-section scaling behavior can reveal their multiquark nature.« less
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Brodsky, Stanley J.; Lebed, Richard F.; Lyubovitskij, Valery E.
2017-01-01
We study the exclusive double-photon annihilation processes, e +e - →γγ* → γV 0 and e +e - γ*γ* Vmore » $$0\\atop{a}$$V$$0\\atop{b}$$, where the V$$0\\atop{i}$$ is a neutral vector meson produced in the forward kinematical region: s>> -t and -t >> Λ$$2\\atop{QCD}$$. We show how the differential cross sections $$dσ\\atop{dt}$$, as predicted by QCD, have additional falloff in the momentum transfer squared t due to the QCD compositeness of the hadrons, consistent with the leading-twist fixed-θ CM scaling laws, both in terms of conventional Feynman diagrams and by using the AdS/QCD holographic model to obtain the results more transparently. However, even though they are exclusive channels and not associated with the conventional electron–positron annihilation process e +e -→γ*→ $$q\\bar{q}$$, these total cross sections σ(e +e -→γV 0)and σ(e +e -→V$$0\\atop{a}$$V$$0\\atop{b}$$), integrated over the dominant forward-and backward-θ CM angular domains, scale as 1/s, and thus contribute to the leading-twist scaling behavior of the ratio R e+e-. We generalize these results to exclusive double-electroweak vector-boson annihilation processes accompanied by the forward production of hadrons, such as e +e -→Z 0V 0and e +e -→W -ρ +. These results can also be applied to the exclusive production of exotic hadrons such as tetraquarks, where the cross-section scaling behavior can reveal their multiquark nature.« less
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Wilkołek, P; Sitkowski, W; Szczepanik, M; Adamek, Ł; Pluta, M; Taszkun, I; Gołyński, M; Malinowska, A
2017-12-01
Allergic responses in humans, horses and other species are mediated by immunoglobulin E (IgE) antibodies. Serum testing to detect allergen-specific IgE antibodies has been developed for dogs, cats and horses; this allows for the identification of allergens and determination of appropriate allergen- specific immunotherapies. This study compared serum allergen-specific IgE concentrations in atopic and healthy horses. The study was performed on Malopolski breed atopic (n=21) and nonatopic (n=21) clinically healthy horses. Allergen-specific IgE serum concentrations were measured in summer seasons of 2008-2015 using a monoclonal anti-IgE antibody. A Northern and Central European allergen panel containing mite, insect, mould and plant pollen allergens, including 15 tests of individual allergens and 5 tests of allergen mixtures was used. The mean allergen-specific IgE concentrations in the atopic and normal horse populations were compared. Among the atopic horses, the strongest positive reactions occurred against the storage mites Tyrophagus putrescentiae and the domestic mite Dermatophagoides farinae. The atopic horses also demonstrated high IgE concentrations against insects, particularly Tabanus sp., the plant pollens colza, cultivated rye and the mould pollen mixture Aspergillus/Penicillium. No horses in the atopic group were IgE-negative. Among all mite, insect, mould and some plant allergen groups the differences in mean specific IgE concentrations between allergic and healthy horses were significant. The mean IgE concentrations for most allergen groups were significantly higher in the atopic horses than in the healthy animals. However, a high incidence of positive reactions was observed in both healthy and allergic horses. Our results showed a high frequency of polysensitization in atopic horses. Copyright© by the Polish Academy of Sciences.
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Heede, Nina G; Thuesen, Betina H; Thyssen, Jacob P; Linneberg, Allan; Szecsi, Pal B; Stender, Steen; Menné, Torkil; Johansen, Jeanne D
2017-08-01
Atopic dermatitis and hand eczema often impair the ability of people to work. Only a few studies have investigated whether individuals with loss-of-function filaggrin gene (FLG) mutations, who often have severe and early onset of dermatitis, experience occupational consequences. To investigate the personal consequences of having atopic dermatitis and/or hand eczema and FLG mutations. Adult Danes from the general population (n = 3247) and patients with atopic dermatitis and/or hand eczema (n = 496) were genotyped for common FLG mutations, and completed a questionnaire about skin symptoms and hand eczema. Socioeconomic variables, including disability pension, and information on work in risk occupations were retrieved from national registries. The reasons for granting disability pension were unknown. Disability pension was associated with hand eczema in the general population, especially among individuals with a history of atopic dermatitis. Moreover, self-reported hand eczema and atopic dermatitis were associated with particularly high risk of disability pension among FLG mutation carriers [odds ratio (OR) 4.02 and 95% confidence interval (CI): 1.15-14.11; and OR 6.01 and 95%CI: 2.37-15.34, respectively]. Furthermore, 60% of the FLG mutation carriers with atopic dermatitis who developed hand eczema had experienced symptoms before adulthood. In the general population, self-reported hand eczema and atopic dermatitis, particularly in individuals with a genetically impaired skin barrier, were associated with disability pension, suggesting that FLG mutations carriers with a history of atopic dermatitis and hand eczema could benefit from early attention with respect to choice of occupation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Dal Negro, R W; Guerriero, M; Micheletto, C
2012-12-01
The increase of basement membrane thickness (BMAT) represents a structural feature described as commonly characterizing airway remodelling in asthma, even if the non-atopic condition had been investigated only episodically from this point of view. Gastrooesophageal-reflux is a pathological condition which can frequently cause and/or sustain asthma in non-atopic individuals. The aim of the study was to measure BMT; some inflammatory mediators in BAL; cys-leucotrienes (LTE4) in urine; e-NO, and BHR to Methacholine (MCh) in mild atopic and in mild non-atopic, GER-related asthma. After their informed consent, 25 mild atopic (40.9 years +/- 13.1 sd, FEV1 = 95.9% pred. +/- 12.9 sd) and 39 non-atopic, GER-related asthmatics (57.3 years +/- 14.2 ds, FEVY1 = 101.3% pred. +/- 12.2 sd), nonsmoker and of a comparable asthma duration, underwent measurements of basal lung function and bronchial response to MCh (PD20 FEV1); endobronchial biopsies and BAL (in the right middle lobe), and a 24-h gastroesophageal pHmetry. Atopic GER-related asthma showed two distinct patterns of airway inflammation. The eosinophilic contribution to airway inflammation was systematically prevailing in the former group, such as: EOS = 10.7% +/- 13.4 sd vs 2.0% +/- 2.8 sd, p = 0.001; ECP = 344.9 mcg/l +/- 635.9 sd vs 59.2 mcg/l +/- 75.1 sd, p = 0.001. Data from the present study are suggesting that persistent mild atopic and mild GER-related asthma seem to represent two distinct phenotypes of asthma in terms of airway remodelling, and in particular of BMT involvement.
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Bonhommeau, D; Lewerenz, M; Halberstadt, N
2008-02-07
We report a theoretical study of the effect induced by a helium nanodroplet environment on the fragmentation dynamics of a dopant. The dopant is an ionized neon cluster Ne(n) (+) (n=4-6) surrounded by a helium nanodroplet composed of 100 atoms. A newly designed mixed quantum/classical approach is used to take into account both the large helium cluster zero-point energy due to the light mass of the helium atoms and all the nonadiabatic couplings between the Ne(n) (+) potential-energy surfaces. The results reveal that the intermediate ionic dopant can be ejected from the droplet, possibly with some helium atoms still attached, thereby reducing the cooling power of the droplet. Energy relaxation by helium atom evaporation and dissociation, the other mechanism which has been used in most interpretations of doped helium cluster dynamics, also exhibits new features. The kinetic energy distribution of the neutral monomer fragments can be fitted to the sum of two Boltzmann distributions, one with a low kinetic energy and the other with a higher kinetic energy. This indicates that cooling by helium atom evaporation is more efficient than was believed so far, as suggested by recent experiments. The results also reveal the predominance of Ne(2) (+) and He(q)Ne(2) (+) fragments and the absence of bare Ne(+) fragments, in agreement with available experimental data (obtained for larger helium nanodroplets). Moreover, the abundance in fragments with a trimeric neon core is found to increase with the increase in dopant size. Most of the fragmentation is achieved within 10 ps and the only subsequent dynamical process is the relaxation of hot intermediate He(q)Ne(2) (+) species to Ne(2) (+) by helium atom evaporation. The dependence of the ionic fragment distribution on the parent ion electronic state reached by ionization is also investigated. It reveals that He(q)Ne(+) fragments are produced only from the highest electronic state, whereas He(q)Ne(2) (+) fragments originate from all the electronic states. Surprisingly, the highest electronic states also lead to fragments that still contain the original ionic dopant species. A mechanism is conjectured to explain this fragmentation inhibition.
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Phase behavior of Langmuir monolayers with ionic molecular heads: Molecular simulations
NASA Astrophysics Data System (ADS)
González-Castro, Carlos A.; Ramírez-Santiago, Guillermo
2015-03-01
We carried out Monte Carlo simulations in the N ,Π,T ensemble of a Langmuir monolayer coarse-grained molecular model. Considering that the hydrophilic groups can be ionized by modulating acid-base interactions, here we study the phase behavior of a model that incorporates the short-range steric and long-range ionic interactions. The simulations were carried out in the reduced temperature range 0.1 ≤T*<4.0 , where there is a competition of these interactions. Different order parameters were calculated and analyzed for several values of the reduced surface pressure in the interval, 1 ≤Π*≤40. For most of the surface pressures two directions of molecular tilt were found: (i) towards the nearest neighbor (NN) at low temperatures, T*<0.7, and most of the values of Π* and (ii) towards next-nearest neighbors (NNN) in the temperature interval 0.7 ≤T*<1.1 for Π*<25. We also found the coexistence of the NN and NNN at intermediate temperatures and Π*>25 . A low-temperature reentrant disorder-order-disorder transition in the positions of the molecular heads and in the collective tilt of the tails was found for all the surface pressure values. It was also found that the molecular tails arranged forming "rotating patterns" in the temperature interval, 0.5
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Assessing Sitting across Contexts: Development of the Multicontext Sitting Time Questionnaire
ERIC Educational Resources Information Center
Whitfield, Geoffrey P.; Pettee Gabriel, Kelley K.; Kohl, Harold W., III.
2013-01-01
Purpose: To describe the development and preliminary evaluation of the Multicontext Sitting Time Questionnaire (MSTQ). Method: During development of the MSTQ, contexts and domains of sitting behavior were utilized as recall cues to improve the accuracy of sitting assessment. The terms "workday" and "nonworkday" were used to…
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Listening to music during sprint interval exercise: The impact on exercise attitudes and intentions.
Stork, Matthew J; Martin Ginis, Kathleen A
2017-10-01
This study investigated the impact of listening to music during exercise on perceived enjoyment, attitudes and intentions towards sprint interval training (SIT). Twenty men (24.8 ± 4.5 years) and women (20.1 ± 2.6 years) unfamiliar with SIT exercise completed two acute sessions of SIT, one with and one without music. Perceived enjoyment, attitudes and intentions towards SIT were measured post-exercise for each condition. Attitudes and intentions to engage in SIT were also measured at baseline and follow-up. Post-exercise attitudes mediated the effects of enjoyment on intentions in the music condition (95% confidence interval [CI]: [0.01, 0.07], κ 2 = 0.36) and in the no music condition (95% CI: [0.01, 0.08], κ 2 = 0.37). Attitudes towards SIT were significantly more positive following the music than no music condition (P = 0.004), while intentions towards SIT were not (P = 0.29). Further, attitudes and intentions towards SIT did not change from baseline to follow-up (Ps > 0.05). These findings revealed that participants had relatively positive attitudes and intentions towards SIT, which did not become more negative despite experiencing intense SIT protocols. This study highlights the importance of acute affective responses to SIT exercise for influencing one's attitudes and intentions towards participating in SIT exercise. Such factors could ultimately play a key role in determining whether an individual engages in SIT exercise in the long term.
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Li, Yingjie; Qiao, Xianliang; Zhang, Ya-Nan; Zhou, Chengzhi; Xie, Huaijun; Chen, Jingwen
2016-10-01
The occurrence of sulfonamide antibiotics (SAs) in estuarine waters urges insights into their environmental fate for ecological risk assessment. Although many studies focused on the photochemical behavior of SAs, yet the effects of halide ions relevant to estuarine and marine environments on their photodegradation have been poorly understood. Here, we investigated the effects of halide ions on the photodegradation of SAs with sulfapyridine, sulfamethazine, and sulfamethoxazole as representative compounds. Results showed that halide ions did not significantly impact the photodegradation of sulfapyridine and sulfamethoxazole, while they significantly promoted the photodegradation of sulfamethazine. Further experiments found that ionic strength applied with NaClO4 significantly enhanced the photodegradation of the SAs, which was attributed to the decreased quenching rate constant of the triplet-excited SAs ((3)SA(∗)). Compared with ionic strength, specific Cl(-) effects retarded the photodegradation of the SAs. Our study found that triplet-excited sulfamethazine can oxidize halide ions to produce halogen radicals, subsequently leading to the halogenation of sulfamethazine, which was confirmed by the identification of both chlorinated and brominated intermediates. These results indicate that halide ions play an important role in the photochemical behavior of some SAs in estuarine waters and seawater. The occurrence of halogenation for certain organic pollutants can be predicted by comparing the oxidation potentials of triplet-excited contaminants with those of halogen radicals. Our findings are helpful in understanding the photochemical behavior and assessing the ecological risks of SAs and other organic pollutants in estuarine and marine environment. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Short-Time Glassy Dynamics in Viscous Protein Solutions with Competing Interactions
Godfrin, P. Douglas; Hudson, Steven; Hong, Kunlun; ...
2015-11-24
Although there have been numerous investigations of the glass transition for colloidal dispersions with only a short-ranged attraction, less is understood for systems interacting with a long-ranged repulsion in addition to this attraction, which is ubiquitous in aqueous protein solutions at low ionic strength. Highly puri ed concentrated lysozyme solutions are used as a model system and investigated over a large range of protein concentrations at very low ionic strength. Newtonian liquid behavior is observed at all concentrations, even up to 480 mg/mL, where the zero shear viscosity increases by more than three orders of magnitude with increasing concentration. Remarkably,more » despite this macroscopic liquid-like behavior, the measurements of the dynamics in the short-time limit shows features typical of glassy colloidal systems. Investigation of the inter-protein structure indicates that the reduced short-time mobility of the protein is caused by localized regions of high density within a heterogeneous density distribution. This structural heterogeneity occurs on intermediate range length scale, driven by the competing potential features, and is distinct from commonly studied colloidal gel systems in which a heterogeneous density distribution tends to extend to the whole system. The presence of long-ranged repulsion also allows for more mobility over large length and long time scales resulting in the macroscopic relaxation of the structure. The experimental results provide evidence for the need to explicitly include intermediate range order in theories for the macroscopic properties of protein solutions interacting via competing potential features.« less
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Ledvina, P S; Tsai, A L; Wang, Z; Koehl, E; Quiocho, F A
1998-12-01
Stringent specificity and complementarity between the receptor, a periplasmic phosphate-binding protein (PBP) with a two-domain structure, and the completely buried and dehydrated phosphate are achieved by hydrogen bonding or dipolar interactions. We recently found that the surface charge potential of the cleft between the two domains that contains the anion binding site is intensely electronegative. This novel finding prompted the study reported here of the effect of ionic strength on the equilibrium and rapid kinetics of phosphate binding. To facilitate this study, Ala197, located on the edge of the cleft, was replaced by a Trp residue (A197W PBP) to generate a fluorescence reporter group. The A197W PBP-phosphate complex retains wild-type Kd and X-ray structure beyond the replacement residue. The Kd (0.18 microM) at no salt is increased by 20-fold at greater than 0.30 M NaCl. Stopped-flow fluorescence kinetic studies indicate a two-step binding process: (1) The phosphate (L) binds, at near diffusion-controlled rate, to the open cleft form (Po) of PBP to produce an intermediate, PoL. This rate decreases with increasing ionic strength. (2) The intermediate isomerizes to the closed-conformation form, PcL. The results indicate that the high specificity, affinity, and rate of phosphate binding are not influenced by the noncomplementary electronegative surface potential of the cleft. That binding depends almost entirely on local dipolar interactions with the receptor has important ramification in electrostatic interactions in protein structures and in ligand recognition.
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Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.
Jensen, B S; Strobaek, D; Christophersen, P; Jorgensen, T D; Hansen, C; Silahtaroglu, A; Olesen, S P; Ahring, P K
1998-09-01
The human intermediate-conductance, Ca2+-activated K+ channel (hIK) was identified by searching the expressed sequence tag database. hIK was found to be identical to two recently cloned K+ channels, hSK4 and hIK1. RNA dot blot analysis showed a widespread tissue expression, with the highest levels in salivary gland, placenta, trachea, and lung. With use of fluorescent in situ hybridization and radiation hybrid mapping, hIK mapped to chromosome 19q13.2 in the same region as the disease Diamond-Blackfan anemia. Stable expression of hIK in HEK-293 cells revealed single Ca2+-activated K+ channels exhibiting weak inward rectification (30 and 11 pS at -100 and +100 mV, respectively). Whole cell recordings showed a noninactivating, inwardly rectifying K+ conductance. Ionic selectivity estimated from bi-ionic reversal potentials gave the permeability (PK/PX) sequence K+ = Rb+ (1.0) > Cs+ (10.4) > Na+, Li+, N-methyl-D-glucamine (>51). NH+4 blocked the channel completely. hIK was blocked by the classical inhibitors of the Gardos channel charybdotoxin (IC50 28 nM) and clotrimazole (IC50 153 nM) as well as by nitrendipine (IC50 27 nM), Stichodactyla toxin (IC50 291 nM), margatoxin (IC50 459 nM), miconazole (IC50 785 nM), econazole (IC50 2.4 microM), and cetiedil (IC50 79 microM). Finally, 1-ethyl-2-benzimidazolinone, an opener of the T84 cell IK channel, activated hIK with an EC50 of 74 microM.
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Epidemiology and Comorbidity in Children with Psoriasis and Atopic Eczema.
Augustin, Matthias; Radtke, Marc A; Glaeske, Gerd; Reich, Kristian; Christophers, Enno; Schaefer, Ines; Jacobi, Arnd
2015-01-01
First studies have shown that juvenile psoriasis is associated with an increased prevalence of comorbidity. We carried out a data analysis to characterise the profiles of comorbidity in children with psoriasis and atopic eczema. Prevalence data were derived from the database of a German statutory health insurance company according to ICD-10 codes L40 (psoriasis) and L20 (atopic eczema) of children up to 18 years insured in 2009. Data sets included 1.64 million persons and 293,181 children. 1,313 children = 0.45% (0.42-0.47) had a diagnosis of psoriasis and 30,354 = 10.35% (10.24-10.47) had a diagnosis of atopic eczema. Obesity, hyperlipidaemia, arterial hypertension and diabetes were more often diagnosed in children with psoriasis in comparison to all children without psoriasis and to those with atopic eczema. Children with psoriasis and atopic eczema show different and specific patterns of comorbidity which should be detected early and treated adequately. © 2015 S. Karger AG, Basel.
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Effect of environmental tobacco smoke on atopic dermatitis among children in Korea.
Yi, Okhee; Kwon, Ho-Jang; Kim, Ho; Ha, Mina; Hong, Soo-Jong; Hong, Yun-Chul; Leem, Jong-Han; Sakong, Joon; Lee, Chul Gab; Kim, Su-Young; Kang, Dongmug
2012-02-01
The prevalence of atopic dermatitis is increasing in many countries. Several factors are known to be associated with childhood atopic dermatitis. Environmental tobacco smoke (ETS) is one of the most common indoor pollutants, and children are more vulnerable to ETS exposure than adults are. In this study, the possible association of ETS with atopic dermatitis was evaluated in 7030 individuals aged 6-13 years who participated in the Children's Health and Environment Research study. In addition, predictive factors, such as the allergic history of the parents, children's immunoglobulin E levels and children's history of rhinitis and its association with dermatitis, were assessed. After adjustment for possible confounding variables, atopic dermatitis was found to be highly correlated with ETS, especially among children whose mothers had smoked during pregnancy and/or in the first year after birth (OR=2.06, 95% CI: 1.01-4.22). In conclusion, our results show that childhood exposure to ETS is a major risk factor for atopic dermatitis. Copyright © 2012 Elsevier Inc. All rights reserved.
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Sensitisation to Aspergillus fumigatus and Penicillium notatum in laboratory workers.
Boscolo, P; Piccolomini, R; Benvenuti, F; Catamo, G; Di Gioacchino, M
1999-01-01
Four workers in medical research laboratories, located in a basement level of a University facility equipped with a humidified air conditioning system, complained of cough and/or asthma and/or rhinitis during their normal working activities. Since exposure to toxic compounds was very low (similar to that of the outdoor environment) only microbiological monitoring was performed. Aspergillus fumigatus and Penicillium notatum were found in some laboratories. Eight laboratory workers (including the 4 symptomatic subjects) out of 26 investigated were found to be atopic. Specific IgE sensitisation to Aspergillus fumigatus was found in the 8 atopic and in the 6 non-atopic workers, while Penicililum notatum was found in 7 atopic and 4 non-atopic subjects. History, physical examination and laboratory data excluded the presence of aspergillosis or allergic bronchial aspergillosis in the sensitised subjects. Our results suggest that evaluation of immune parameters, along with monitoring of the working environment, may reduce the risk of sensitisation and/or allergic symptoms in atopic laboratory workers.
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Altered cytokine production by dendritic cells from infants with atopic dermatitis.
Yao, Weiguo; Chang, JiHoon; Sehra, Sarita; Travers, Jeffrey B; Chang, Cheong-Hee; Tepper, Robert S; Kaplan, Mark H
2010-12-01
Dendritic cells (DC) are potent initiators of immune responses, compared to other professional antigen-presenting cells, based on their ability to capture antigen, express high amounts of MHC and co-stimulatory molecules, and to secrete immunostimulatory cytokines. Altered functions of DC in atopic individuals have been observed, though it is not clear if this is a cause or a result of the development of allergic disease. In this report we demonstrate altered cytokine production by DC isolated from infants with atopic dermatitis but without a diagnosis of asthma, compared to infants with non-atopic dermatitis. Increased production of IL-6, IL-10 and IFNα from DC isolated from atopic infants is less apparent when DC from infants were examined 1 year later. An increase in the same cytokines was observed in neonatal mice that are genetically predisposed towards allergic inflammation. These results suggest that an atopic environment promotes altered cytokine production by DC from infants. Copyright © 2010 Elsevier Inc. All rights reserved.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Lesne, Vincent
Dans le cadre du modele mSUGRA qui decrit un mecanisme de brisure simple de la supersym etrie, des sparticules avec des masses au-del a des limites fixees par les experiences de LEP II peuvent etre produites au Tevatron, collisionneur pmore » $$\\bar{p}$$ delivrant une energie de 1.96 TeV dans le centre de masse. Un canal privilegie pour la d´ecouverte de la supersymetrie au Tevatron est la production associee du plus leger chargino, $$\\tilde{χ}$$$±\\atop{1}$$ , et du second plus leger neutralino, $$\\tilde{χ}$$$0\\atop{2}$$ . Les modes de desintegration leptoniques, $$\\tilde{χ}$$$0\\atop{2}$$ → $$\\tilde{χ}$$$0\\atop{1}$$ ℓ +ℓ - et $$\\tilde{χ}$$$±\\atop{1}$$ → $$\\tilde{χ}$$$0\\atop{1}$$ ℓ ±ν l, conduisent a une signature claire avec trois leptons et un quantite significative d’energie transverse manquante.« less
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Resonant interatomic Coulombic decay in HeNe: Electron angular emission distributions
NASA Astrophysics Data System (ADS)
Mhamdi, A.; Trinter, F.; Rauch, C.; Weller, M.; Rist, J.; Waitz, M.; Siebert, J.; Metz, D.; Janke, C.; Kastirke, G.; Wiegandt, F.; Bauer, T.; Tia, M.; Cunha de Miranda, B.; Pitzer, M.; Sann, H.; Schiwietz, G.; Schöffler, M.; Simon, M.; Gokhberg, K.; Dörner, R.; Jahnke, T.; Demekhin, Ph. Â. V.
2018-05-01
We present a joint experimental and theoretical study of resonant interatomic Coulombic decay (RICD) in HeNe employing high resolution cold target recoil ion momentum spectroscopy and ab initio electronic structure and nuclear dynamics calculations. In particular, laboratory- and molecular-frame angular emission distributions of RICD electrons are examined in detail. The exciting-photon energy-dependent anisotropy parameter β (ω ) , measured for decay events that populate bound HeNe+ ions, is in agreement with the calculations performed for the ground ionic state X2Σ1/2 + . A contribution from the a2Π3 /2 final ionic state is found to be negligible. For the He +Ne+ fragmentation channel, the observed laboratory-frame angular distribution of RICD electrons is explained by a slow homogeneous dissociation of bound vibrational levels of the final ionic state A2Π1 /2 into vibrational continua of the lower lying states X2Σ1/2 + and a2Π3 /2 . Our calculations predict that the angular distributions of RICD electrons in the body-fixed dipole plane provide direct access to the electronic character (i.e., symmetry) of intermediate vibronic resonances. However, because of the very slow dissociation of the A2Π1 /2 state, the molecular-frame angular distributions of RICD electrons in the He +Ne+ fragmentation channel are inaccessible to our coincidence experiment.
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Influence of sex on microvascular and macrovascular responses to prolonged sitting.
Vranish, Jennifer R; Young, Benjamin E; Kaur, Jasdeep; Patik, Jordan C; Padilla, Jaume; Fadel, Paul J
2017-04-01
Increased daily sitting time is associated with greater cardiovascular risk, and, on average, women are more sedentary than men. Recent reports have demonstrated that prolonged sitting reduces lower leg microvascular (reactive hyperemia) and macrovascular [flow-mediated dilation (FMD)] vasodilator function. However, these studies have predominately included men, and the effects of sitting in young women are largely unexplored. This becomes important given known sex differences in vascular function. Thus, herein, we assessed popliteal artery reactive hyperemia and FMD before and after a 3-h sitting period in healthy young women ( n = 12) and men ( n = 8). In addition, resting popliteal artery hemodynamics (duplex Doppler ultrasound) and calf circumference were measured before, during, and after sitting. Resting popliteal artery shear rate was reduced to a similar extent in both groups during the sitting period (women: -48.5 ± 8.4 s -1 and men: -52.9 ± 12.3 s -1 , P = 0.45). This was accompanied by comparable increases in calf circumference in men and women ( P = 0.37). After the sitting period, popliteal artery FMD was significantly reduced in men (PreSit: 5.5 ± 0.9% and PostSit: 1.6 ± 0.4%, P < 0.001) but not women (PreSit: 4.4 ± 0.6% and PostSit: 3.6 ± 0.6%, P = 0.29). In contrast, both groups demonstrated similar reductions in hyperemic blood flow area under the curve (women: -28,860 ± 5,742 arbitrary units and men: -28,691 ± 9,685 arbitrary units, P = 0.99), indicating impaired microvascular reactivity after sitting. These findings indicate that despite comparable reductions in shear rate during 3 h of uninterrupted sitting, macrovascular function appears protected in some young women but the response was variable, whereas men exhibited more consistent reductions in FMD. In contrast, the leg microvasculature is susceptible to similar sitting-induced impairments in men and women. NEW & NOTEWORTHY We demonstrate that leg macrovascular function was consistently reduced in young men but not young women after prolonged sitting. In contrast, both men and women exhibited similar reductions in leg microvascular reactivity after sitting. These data demonstrate, for the first time, sex differences in vascular responses to prolonged sitting. Copyright © 2017 the American Physiological Society.
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Zhang, Keda; Abraham, Michael H; Liu, Xiangli
2017-04-15
Experimental values of permeability coefficients, as log K p , of chemical compounds across human skin were collected by carefully screening the literature, and adjusted to 37°C for the effect of temperature. The values of log K p for partially ionized acids and bases were separated into those for their neutral and ionic species, forming a total data set of 247 compounds and species (including 35 ionic species). The obtained log K p values have been regressed against Abraham solute descriptors to yield a correlation equation with R 2 =0.866 and SD=0.432 log units. The equation can provide valid predictions for log K p of neutral molecules, ions and ionic species, with predictive R 2 =0.858 and predictive SD=0.445 log units calculated by the leave-one-out statistics. The predicted log K p values for Na + and Et 4 N + are in good agreement with the observed values. We calculated the values of log K p of ketoprofen as a function of the pH of the donor solution, and found that log K p markedly varies only when ketoprofen is largely ionized. This explains why models that neglect ionization of permeants still yield reasonable statistical results. The effect of skin thickness on log K p was investigated by inclusion of two indicator variables, one for intermediate thickness skin and one for full thickness skin, into the above equation. The newly obtained equations were found to be statistically very close to the above equation. Therefore, the thickness of human skin used makes little difference to the experimental values of log K p . Copyright © 2017 Elsevier B.V. All rights reserved.
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Nielsen, L; Khurana, R; Coats, A; Frokjaer, S; Brange, J; Vyas, S; Uversky, V N; Fink, A L
2001-05-22
In the search for the molecular mechanism of insulin fibrillation, the kinetics of insulin fibril formation were studied under different conditions using the fluorescent dye thioflavin T (ThT). The effect of insulin concentration, agitation, pH, ionic strength, anions, seeding, and addition of 1-anilinonaphthalene-8-sulfonic acid (ANS), urea, TMAO, sucrose, and ThT on the kinetics of fibrillation was investigated. The kinetics of the fibrillation process could be described by the lag time for formation of stable nuclei (nucleation) and the apparent rate constant for the growth of fibrils (elongation). The addition of seeds eliminated the lag phase. An increase in insulin concentration resulted in shorter lag times and faster growth of fibrils. Shorter lag times and faster growth of fibrils were seen at acidic pH versus neutral pH, whereas an increase in ionic strength resulted in shorter lag times and slower growth of fibrils. There was no clear correlation between the rate of fibril elongation and ionic strength. Agitation during fibril formation attenuated the effects of insulin concentration and ionic strength on both lag times and fibril growth. The addition of ANS increased the lag time and decreased the apparent growth rate for insulin fibril formation. The ANS-induced inhibition appears to reflect the formation of amorphous aggregates. The denaturant, urea, decreased the lag time, whereas the stabilizers, trimethylamine N-oxide dihydrate (TMAO) and sucrose, increased the lag times. The results indicated that both nucleation and fibril growth were controlled by hydrophobic and electrostatic interactions. A kinetic model, involving the association of monomeric partially folded intermediates, whose concentration is stimulated by the air-water interface, leading to formation of the critical nucleus and thence fibrils, is proposed.
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Lubbes, Stefanie; Rustemeyer, Thomas; Sillevis Smitt, Johannes H; Schuttelaar, Marie Louise; Middelkamp-Hup, Maritza A
2017-03-01
Allergic contact dermatitis is known to occur in children with and without atopic dermatitis, but more data are needed on contact sensitization profiles in these two groups. To identify frequent allergens in children with and without atopic dermatitis suspected of having allergic contact dermatitis. A retrospective analysis of children aged 0-17 years patch tested between 1996 and 2013 was performed. Of all 1012 children tested because of suspected contact dermatitis, 46% developed one or more positive reactions, the proportions for children with (n = 526) and without (n = 395) atopic dermatitis being 48% and 47%, respectively. Children with atopic dermatitis reacted more often to lanolin alcohol (30% pet., p = 0.030), Amerchol L-101 (p = 0.030), and fragrances [fragrance mix I (p = 0.048) and Myroxylon pereirae (p = 0.005)]. Allergens outside the European baseline series that frequently gave positive reactions in these groups included cocamidopropyl betaine and Amerchol L-101. Reactivity to these allergens was significantly more common in atopic dermatitis children. Sensitization prevalences in children with and without atopic dermatitis were similar, but children with atopic dermatitis reacted significantly more often to lanolin alcohol and fragrances. Testing with additional series besides the European baseline series may be necessary, as reactions to, for example, cocamidopropyl betaine and Amerchol L-101 may otherwise be missed. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Atopic conditions and mental health problems: a 3-year follow-up study.
Lien, Lars; Green, Kristian; Thoresen, Magne; Bjertness, Espen
2010-09-01
The aim of this study was to test the hypothesis that atopic conditions at 15/16 years of age affect both internalized and externalized mental health problems 3 years later. Combined school and postal survey was conducted in urban and rural settings. A total of 3,674 adolescents (70.1% response rate) were followed at two time points and interviewed with similar questionnaires at baseline and follow-up. Hopkins Symptoms Checklist (HSCL-10) was used to assess internalized problems, and two subscales (conduct problems and hyperactivity) from the Strength and Difficulties Questionnaire to measure externalized mental health problems. The atopic conditions investigated were asthma, hay fever and eczema by asking the adolescents whether these conditions were present or not. There was an increase in the prevalence of internalized mental health problems from about 17-25% and a decrease in externalized mental health problems and number of atopic conditions in the follow-up period. Of the atopic conditions, hay fever was most prevalent with about 34% at 15 years of age and 20% at 18. The asthma prevalence was at 10 and 5% and eczema at 25 and 10%, respectively. Internalized mental health problems among girls were significantly associated with atopic conditions 3 years earlier, also after controlling for confounding variables. To live with atopic conditions seem to affect the mood and level of anxiety among adolescent girls. This should be kept in mind by health professionals treating young girls with atopic conditions.
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Gao, Ying; Cronin, Neil J; Pesola, Arto J; Finni, Taija
2016-10-01
Reducing sitting time by means of sit-stand workstations is an emerging trend, but further evidence is needed regarding their health benefits. This cross-sectional study compared work time muscle activity patterns and spinal shrinkage between office workers (aged 24-62, 58.3% female) who used either a sit-stand workstation (Sit-Stand group, n = 10) or a traditional sit workstation (Sit group, n = 14) for at least the past three months. During one typical workday, muscle inactivity and activity from quadriceps and hamstrings were monitored using electromyography shorts, and spinal shrinkage was measured using stadiometry before and after the workday. Compared with the Sit group, the Sit-Stand group had less muscle inactivity time (66.2 ± 17.1% vs. 80.9 ± 6.4%, p = 0.014) and more light muscle activity time (26.1 ± 12.3% vs. 14.9 ± 6.3%, p = 0.019) with no significant difference in spinal shrinkage (5.62 ± 2.75 mm vs. 6.11 ± 2.44 mm). This study provides evidence that working with sit-stand workstations can promote more light muscle activity time and less inactivity without negative effects on spinal shrinkage. Practitioner Summary: This cross-sectional study compared the effects of using a sit-stand workstation to a sit workstation on muscle activity patterns and spinal shrinkage in office workers. It provides evidence that working with a sit-stand workstation can promote more light muscle activity time and less inactivity without negative effects on spinal shrinkage.
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Waongenngarm, Pooriput; Rajaratnam, Bala S.; Janwantanakul, Prawit
2015-01-01
Background Prolonged sitting leads to low back discomfort and lumbopelvic muscle fatigue. This study examined the characteristics of body perceived discomfort and trunk muscle fatigue during 1 hour of sitting in three postures in office workers. Methods Thirty workers sat for 1 hour in one of three sitting postures (i.e., upright, slumped, and forward leaning postures). Body discomfort was assessed using the Body Perceived Discomfort scale at the beginning and after 1 hour of sitting. Electromyographic (EMG) signals were recorded from superficial lumbar multifidus, iliocostalis lumborum pars thoracis, internal oblique (IO)/transversus abdominis (TrA), and rectus abdominis muscles during 1 hour of sitting. The median frequency (MDF) of the EMG power spectrum was calculated. Results Regardless of the sitting posture, the Body Perceived Discomfort scores in the neck, shoulder, upper back, low back, and buttock significantly increased after 1 hour of sitting compared with baseline values (t(9) = −11.97 to −2.69, p < 0.05). The MDF value of the EMG signal of rectus abdominis, iliocostalis lumborum pars thoracis, and multifidus muscles was unchanged over time in all three sitting postures. Only the right and left IO/TrA in the slumped sitting posture was significantly associated with decreased MDF over time (p = 0.019 to 0.041). Conclusion Prolonged sitting led to increased body discomfort in the neck, shoulder, upper back, low back, and buttock. No sign of trunk muscle fatigue was detected over 1 hour of sitting in the upright and forward leaning postures. Prolonged slumped sitting may relate to IO/TrA muscle fatigue, which may compromise the stability of the spine, making it susceptible to injury. PMID:27014491
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Haba-Rubio, José; Sforza, Emilia
2006-10-01
To evaluate the test-to-test variability of the suggested immobilization test (SIT) in patients with restless legs syndrome (RLS). Twenty patients with primary RLS (12 men and eight women; age: 53.3+/-11.3 years) were selected for the study. We compared the results of two SITs performed on two consecutive evenings prior to polysomnographic recordings. Overall, the periodic leg movement index during the SIT (SIT PLM) and the SIT PLM index associated with sensory manifestations (SIT PLM+) were not significantly different between tests. The number of PLM sequences per SIT, the mean PLM duration and the PLM interval did not significantly change between the two consecutive tests. The pattern of temporal evolution of motor activity across the SIT was very reproducible, SIT PLM showing a clear tendency to a progressive increase across the test, with the SIT PLM+ index decreasing in the second half of the test. Despite good reproducibility, there were marked intra-individual differences. Considering the proposed cut-off value of 12 for the SIT PLM index to confirm RLS, 11 patients were positive at the first test and four additional patients became positive at the second test. SIT PLM index changes did not correlate with age, severity of disease and polysomnographic measures. Quantitative analysis of motor activity during two consecutive SITs in RLS patients showed a significant inter-test intra-individual variability unrelated to demographic, clinical or polysomnographic parameters. SIT PLM index variability suggests that a single test would not be sensitive enough for diagnostic purposes in unclear cases and that new criteria need to be applied to increase its specificity and sensitivity.
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Ayotte, Patrick; Plessis, Sylvain; Marchand, Patrick
2008-08-28
A molecular-level description of the structural and dynamical aspects that are responsible for the weak acid behaviour of dilute hydrofluoric acid solutions and their unusual increased acidity at near equimolar concentrations continues to elude us. We address this problem by reporting reflection-absorption infrared spectra (RAIRS) of cryogenic HF-H(2)O binary mixtures at various compositions prepared as nanoscopic films using molecular beam techniques. Optical constants for these cryogenic solutions [n(omega) and k(omega)] are obtained by iteratively solving Fresnel equations for stratified media. Modeling of the experimental RAIRS spectra allow for a quantitative interpretation of the complex interplay between multiple reflections, optical interference and absorption effects. The evolution of the strong absorption features in the intermediate 1000-3000 cm(-1) range with increasing HF concentration reveals the presence of various ionic dissociation intermediates that are trapped in the disordered H-bonded network of cryogenic hydrofluoric acid solutions. Our findings are discussed in light of the conventional interpretation of why hydrofluoric acid is a weak acid revealing molecular-level details of the mechanism for HF ionization that may be relevant to analogous elementary processes involved in the ionization of weak acids in aqueous solutions.
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Can a smart chair improve the sitting behavior of office workers?
Roossien, C C; Stegenga, J; Hodselmans, A P; Spook, S M; Koolhaas, W; Brouwer, S; Verkerke, G J; Reneman, M F
2017-11-01
Prolonged sitting can cause health problems and musculoskeletal discomfort. There is a need for objective and non-obstructive means of measuring sitting behavior. A 'smart' office chair can monitor sitting behavior and provide tactile feedback, aiming to improve sitting behavior. This study aimed to investigate the effect of the feedback signal on sitting behavior and musculoskeletal discomfort. In a 12-week prospective cohort study (ABCB design) among office workers (n = 45) was measured sitting duration and posture, feedback signals and musculoskeletal discomfort. Between the study phases, small changes were observed in mean sitting duration, posture and discomfort. After turning off the feedback signal, a slight increase in sitting duration was observed (10 min, p = 0.04), a slight decrease in optimally supported posture (2.8%, p < 0.01), and musculoskeletal discomfort (0.8, p < 0.01) was observed. We conclude that the 'smart' chair is able to monitor the sitting behavior, the feedback signal, however, led to small or insignificant changes. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Gupta, Nidhi; Christiansen, Caroline Stordal; Hanisch, Christiana; Bay, Hans; Burr, Hermann; Holtermann, Andreas
2017-01-16
To investigate the differences between a questionnaire-based and accelerometer-based sitting time, and develop a model for improving the accuracy of questionnaire-based sitting time for predicting accelerometer-based sitting time. 183 workers in a cross-sectional study reported sitting time per day using a single question during the measurement period, and wore 2 Actigraph GT3X+ accelerometers on the thigh and trunk for 1-4 working days to determine their actual sitting time per day using the validated Acti4 software. Least squares regression models were fitted with questionnaire-based siting time and other self-reported predictors to predict accelerometer-based sitting time. Questionnaire-based and accelerometer-based average sitting times were ≈272 and ≈476 min/day, respectively. A low Pearson correlation (r=0.32), high mean bias (204.1 min) and wide limits of agreement (549.8 to -139.7 min) between questionnaire-based and accelerometer-based sitting time were found. The prediction model based on questionnaire-based sitting explained 10% of the variance in accelerometer-based sitting time. Inclusion of 9 self-reported predictors in the model increased the explained variance to 41%, with 10% optimism using a resampling bootstrap validation. Based on a split validation analysis, the developed prediction model on ≈75% of the workers (n=132) reduced the mean and the SD of the difference between questionnaire-based and accelerometer-based sitting time by 64% and 42%, respectively, in the remaining 25% of the workers. This study indicates that questionnaire-based sitting time has low validity and that a prediction model can be one solution to materially improve the precision of questionnaire-based sitting time. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
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De Cocker, Katrien; Duncan, Mitch J; Short, Camille; van Uffelen, Jannique G Z; Vandelanotte, Corneel
2014-10-01
To (1) compare occupational sitting between different socio-demographic, health-related, work-related and psychosocial categories, (2) identity socio-demographic, health-related, work-related and psychosocial correlates of occupational sitting, and (3) examine the moderating effect of work-related factors in the relation between correlates and occupational sitting. Randomly-selected Australian adults completed a web-based survey assessing socio-demographic (country of birth, gender, age, education, income), health-related (general health, weight, physical activity), work-related (employment status, occupational task, occupational classification) and sedentary-specific psychosocial (social norm, social support, self-efficacy, control, advantages, disadvantage, intention) factors, and occupational sitting-time. t-tests, ANOVAs and multiple linear regression analyses were conducted (in 2013) on a sample of employees (n=993). Respondents sat on average for 3.75 (SD=2.45) h/day during work. Investigated correlates explained 41% of the variance in occupational sitting. More occupational sitting was associated with being male, being younger, higher education and income, part-time and full-time employment, sedentary job tasks, white-collar/professional occupations, higher BMI, and perceiving more advantages of sitting less at work. Employment status and occupational classification moderated the association between control to sit less and occupational sitting. A lack of control to sit less was associated with higher occupational sitting in part-time and full-time workers, but not in casual workers; and in white-collar and professional workers, but not in blue-collar workers. Most important contributors to occupational sitting were work-related and socio-demographic correlates. More research is needed to confirm present results. Copyright © 2014 Elsevier Inc. All rights reserved.
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O'Sullivan, Kieran; McCarthy, Raymond; White, Alison; O'Sullivan, Leonard; Dankaerts, Wim
2012-01-01
Low back pain (LBP) is a common musculoskeletal disorder and prolonged sitting often aggravates LBP. A novel dynamic ergonomic chair ('Back App'), which facilitates less hip flexion while sitting on an unstable base has been developed. This study compared lumbar posture and trunk muscle activation on this novel chair with a standard backless office chair. Twelve painfree participants completed a typing task on both chairs. Lumbar posture and trunk muscle activation were collected simultaneously and were analysed using paired t-tests. Sitting on the novel dynamic chair significantly (p < 0.05) reduced both lumbar flexion and the activation of one back muscle (Iliocostalis Lumborum pars Thoracis). The discomfort experienced was mild and was similar (p > 0.05) between chairs. Maintaining lordosis with less muscle activation during prolonged sitting could reduce the fatigue associated with upright sitting postures. Studies with longer sitting durations, and in people with LBP, are required. Sitting on a novel dynamic chair resulted in less lumbar flexion and less back muscle activation than sitting on a standard backless office chair during a typing task among pain-free participants. Facilitating lordotic sitting with less muscle activation may reduce the fatigue and discomfort often associated with lordotic sitting postures.
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Grades of Severity and the Validation of an Atopic Dermatitis Assessment Measure (ADAM).
ERIC Educational Resources Information Center
Charman, Denise P.; Varigos, George A.
1999-01-01
Studied the validity of the Atopic Dermatitis Assessment Measure (D. Charman and others, 1999) with 171 pediatric patients in Australia using partial credit analyses to produce clinically relevant "word pictures" of grades of severity for atopic dermatitis. Discusses implications for measurement in medicine. (SLD)
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[Inpatient rehabilitation of chronic dermatoses illustrated by atopic dermatitis].
Nürnberg, W
2005-07-01
Atopic dermatitis is defined as a chronically relapsing skin disease resulting from complex interactions between genetic and environmental factors. It usually occurs during early childhood and shows typical clinical manifestations, depending on the patient's age. In cases of chronic atopic dermatitis, negative effects on professional and social activities and participation have to be expected. To counteract or overcome these threatening impairments in the different facets of life, prescribing inpatient rehabilitative measures should be considered early. Dermatological rehabilitation according to guidelines guarantees an interdisciplinary and multimodal treatment of atopic dermatitis.
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Top Quark Mass Calibration for Monte Carlo Event Generators
Butenschoen, Mathias; Dehnadi, Bahman; Hoang, André H.; ...
2016-11-29
The most precise top quark mass measurements use kinematic reconstruction methods, determining the top mass parameter of a Monte Carlo event generator mmore » $$MC\\atop{t}$$. Because of hadronization and parton-shower dynamics, relating m$$MC\\atop{t}$$ to a field theory mass is difficult. Here, we present a calibration procedure to determine this relation using hadron level QCD predictions for observables with kinematic mass sensitivity. Fitting e +e −2-jettiness calculations at next-to-leading-logarithmic and next-to-next-to-leading-logarithmic order to PYTHIA 8.205, m$$MC\\atop{t}$$ differs from the pole mass by 900 and 600 MeV, respectively, and agrees with the MSR mass within uncertainties, m$$MC\\atop{t}$$ ≃ m$$MSR\\atop{t,1 GeV}$$.« less
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Buzney, Catherine D; Gottlieb, Alice B; Rosmarin, David
2016-02-01
Type 2 helper T cell (Th2)-mediated inflammation plays a critical role in the pathogenesis of allergic asthma and atopic dermatitis (AD). Recent research focusing on the suppression of the Th2 axis with targeted inhibitors in atopic disease is showing promising early results. In particular, the simultaneous blockage of interleukin (IL)-4 and IL-13 has successfully mitigated symptoms of allergic asthma and AD in preliminary clinical trials. Given the current therapeutic challenges of treating these chronic and severe diseases, this review brings to light new data demonstrating that agents targeting IL-4 and IL-13 are relatively safe and effective medications in blocking the inflammatory cascade responsible for allergic asthma and atopic dermatitis.
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Infant feeding and the development of food allergies and atopic eczema: An update.
Gamboni, Sarah E; Allen, Katrina J; Nixon, Rosemary L
2013-05-01
There is an increasing awareness of food allergies in the community. Dermatologists frequently see patients with atopic eczema, where parents are extremely concerned about the role of food allergy. Advice given to parents regarding the timing of introduction of solid foods has changed markedly over the past decade. Whereas previous advice advocated delaying the introduction of solid foods until the infant's gastrointestinal system had matured, recent studies suggest that the introduction of solids from around 4 to 6 months may actually prevent the development of allergies. Studies on maternal dietary restrictions during pregnancy and lactation have led researchers to believe that antigen avoidance does not play a significant role in the prevention of atopic disease. Breastfeeding exclusively for 4 to 6 months has multiple benefits for mother and child, however, it does not convincingly prevent food allergies or decrease atopic eczema. New evidence suggests that the use of hydrolysed formulas does not delay or prevent atopic eczema or food allergy. This article aims to highlight current evidence and provide an update for dermatologists on the role of food exposure in the development of atopic disease, namely atopic eczema. © 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.
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Amplitude analysis of B - → D + π - π - decays
DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaij, R.; Adeva, B.; Adinolfi, M.
The Dalitz plot analysis technique is used to study the resonant substructures of B - → D + π - π - decays in a data sample corresponding to 3.0 fb -1 of pp collision data recorded by the LHCb experiment during 2011 and 2012. A model-independent analysis of the angular moments demonstrates the presence of resonances with spins 1, 2 and 3 at high D + π - mass. The data are fitted with an amplitude model composed of a quasi-model-independent function to describe the D + π - S wave together with virtual contributions from the D*(2007) 0 and B* 0 states, and components corresponding to the Dmore » $$*\\atop{2}$$(2460) 0, D$$*\\atop{1}$$(2680) 0 , D$$*\\atop{3}$$(2760) 0 and D$$*\\atop{2}$$(3000) 0 resonances. The masses and widths of these resonances are determined together with the branching fractions for their production in B- → D +π - π - decays. The D + π - S wave has phase motion consistent with that expected due to the presence of the D$$*\\atop{0}$$(2400) 0 state. These results constitute the first observations of the D$$*\\atop{3}$$(2760) 0 and D$$*\\atop{2}$$(3000) 0 resonances, with significances of 10σ and 6.6σ, respectively.« less
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1997-11-01
ETAC (Early Treatment of the Atopic Child), a multi-centre predominantly European study to investigate the potential for cetirizine to prevent the development of asthma in infants with atopic dermatitis has completed enrollment: 817 children have been randomised to 18 months' treatment with either active or placebo and a subsequent 18 months of post-treatment follow-up. Results of the therapeutic effects will not be available for some time, but the study has provided an opportunity to investigate influences on sensitization to allergens in a large cohort of 1-2 years olds with already established atopic dermatitis, resident in different countries and in different environments. The study shows that in infants with atopic dermatitis, raised serum total IgE has significantly different determinants from that a specific allergen sensitization. In infancy, increased total IgE is more affected by factors increasing risk of intercurrent infection and non-specific airway inflammation, such as environmental tobacco smoke exposure (p < 0.001) and the use of gas cookers (p = 0.02). Specific allergen sensitization as represented by detectable IgE antibodies is influenced primarily by allergen exposure. In Sweden, low level exposure to allergens is associated with reduced specific allergen sensitization rates even though the infants already have atopic dermatitis.
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Amplitude analysis of B - → D + π - π - decays
Aaij, R.; Adeva, B.; Adinolfi, M.; ...
2016-10-05
The Dalitz plot analysis technique is used to study the resonant substructures of B - → D + π - π - decays in a data sample corresponding to 3.0 fb -1 of pp collision data recorded by the LHCb experiment during 2011 and 2012. A model-independent analysis of the angular moments demonstrates the presence of resonances with spins 1, 2 and 3 at high D + π - mass. The data are fitted with an amplitude model composed of a quasi-model-independent function to describe the D + π - S wave together with virtual contributions from the D*(2007) 0 and B* 0 states, and components corresponding to the Dmore » $$*\\atop{2}$$(2460) 0, D$$*\\atop{1}$$(2680) 0 , D$$*\\atop{3}$$(2760) 0 and D$$*\\atop{2}$$(3000) 0 resonances. The masses and widths of these resonances are determined together with the branching fractions for their production in B- → D +π - π - decays. The D + π - S wave has phase motion consistent with that expected due to the presence of the D$$*\\atop{0}$$(2400) 0 state. These results constitute the first observations of the D$$*\\atop{3}$$(2760) 0 and D$$*\\atop{2}$$(3000) 0 resonances, with significances of 10σ and 6.6σ, respectively.« less
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Tanaka, Keiko; Miyake, Yoshihiro; Furukawa, Shinya; Arakawa, Masashi
2017-07-01
Epidemiological evidence regarding the effect of perinatal smoking exposure on atopic eczema in children continues to be inconclusive. The aim of this prospective prebirth cohort study was to investigate the association between prenatal smoking exposure and postnatal living with household smokers and the risk of atopic eczema in Japanese children aged 23 to 29 months. Study subjects were 1354 Japanese mother-child pairs. Information on the variables under study was obtained through questionnaires which were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, and 24 months after delivery. Eczema in the last 12 months was defined according to the criteria of the International Study of Asthma and Allergies in Childhood. Physician-diagnosed atopic eczema was considered present if reported by mothers. Compared with no perinatal smoking exposure, prenatal smoking exposure only was associated with an increased risk of physician-diagnosed atopic eczema (adjusted odds ratio = 7.11, 95% confidence interval: 1.43 to 27.8). Postnatal living with at least one household smoker only was not associated with the risk of physician-diagnosed atopic eczema; neither was the combination of both prenatal smoking exposure and postnatal living with at least one household smoker. No association was observed between perinatal smoking exposure status and the risk of eczema as defined according to the International Study of Asthma and Allergies in Childhood criteria. Our findings suggest that maternal smoking during pregnancy may increase the risk of atopic eczema in young children. In the present prebirth cohort study, we assessed the independent and additive effects of pre- and postnatal exposure to tobacco smoking on atopic eczema in children. Compared with no perinatal smoking exposure, prenatal smoking exposure only was significantly associated with an increased risk of atopic eczema. Postnatal smoking exposure only was not associated with the risk of atopic eczema; neither was the combination of both pre- and postnatal smoking exposure. This is the first epidemiological study to show a positive association between prenatal smoking exposure only and the risk of atopic eczema. © The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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De Cocker, Katrien; De Bourdeaudhuij, Ilse; Cardon, Greet; Vandelanotte, Corneel
2016-05-31
Effective interventions to influence workplace sitting are needed, as office-based workers demonstrate high levels of continued sitting, and sitting too much is associated with adverse health effects. Therefore, we developed a theory-driven, Web-based, interactive, computer-tailored intervention aimed at reducing and interrupting sitting at work. The objective of our study was to investigate the effects of this intervention on objectively measured sitting time, standing time, and breaks from sitting, as well as self-reported context-specific sitting among Flemish employees in a field-based approach. Employees (n=213) participated in a 3-group randomized controlled trial that assessed outcomes at baseline, 1-month follow-up, and 3-month follow-up through self-reports. A subsample (n=122) were willing to wear an activity monitor (activPAL) from Monday to Friday. The tailored group received an automated Web-based, computer-tailored intervention including personalized feedback and tips on how to reduce or interrupt workplace sitting. The generic group received an automated Web-based generic advice with tips. The control group was a wait-list control condition, initially receiving no intervention. Intervention effects were tested with repeated-measures multivariate analysis of variance. The tailored intervention was successful in decreasing self-reported total workday sitting (time × group: P<.001), sitting at work (time × group: P<.001), and leisure time sitting (time × group: P=.03), and in increasing objectively measured breaks at work (time × group: P=.07); this was not the case in the other conditions. The changes in self-reported total nonworkday sitting, sitting during transport, television viewing, and personal computer use, objectively measured total sitting time, and sitting and standing time at work did not differ between conditions. Our results point out the significance of computer tailoring for sedentary behavior and its potential use in public health promotion, as the effects of the tailored condition were superior to the generic and control conditions. Clinicaltrials.gov NCT02672215; http://clinicaltrials.gov/ct2/show/NCT02672215 (Archived by WebCite at http://www.webcitation.org/6glPFBLWv).
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Medina, Catalina; Tolentino-Mayo, Lizbeth; López-Ridaura, Ruy; Barquera, Simón
2017-01-01
Sedentary behaviors such as sitting time are associated with obesity and diabetes independently of total reported physical activity. This study aimed to describe the current sitting time/day prevalence and trends and to examine the association of sitting time with sociodemographic and clinical variables in Mexico City. Two cross-sectional representative surveys in Mexico City were used for this analysis (2006: n = 1148 and 2015: n = 1329). Sedentary behavior questions from the International Physical Activity Questionnaire included time spent sitting on a weekday in the last week or on a Wednesday. Sitting time /day was divided into deciles, and participants in the highest decile (≥ 420 minutes/day) were classified within the high sitting category; others were classified in the low sitting time category. Multivariate logistic regression was used to evaluate the associations of sitting time with sociodemographic and clinical indicators, controlling for confounders and testing for potential interactions. A total of 13.7% (2006) and 14.8% (2015) adults were classified in the highest sitting time category (≥ 420 minutes/day). There was a significant increase in the average sitting time/day between the surveys (216.0 minutes in 2006 vs. 233.3 minutes in 2015, p < 0.001). In 2015, men, those aged 20-49 years, those in low-intensity jobs, students, and those with a high socioeconomic level were more likely to be in the highest sitting time category. Participants with overweight/obesity (OR = 2.37, 95% CI: 1.11, 5.09) and those with high glucose levels (survey finding) (OR = 2.34, 95% CI: 1.04, 5.25) were more likely to report sitting time in the highest category. Sitting time/day prevalence increased 8%, and average daily sitting minutes significantly increased by 8.2% (18 minutes) in the nine-year study period (2006-2015). Current public health policies should consider strategies not only for increasing physical activity levels, but also for reducing sitting time/day among the population as a measure to fight the growing epidemic of obesity and diabetes in Mexico.
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Tolentino-Mayo, Lizbeth; López-Ridaura, Ruy; Barquera, Simón
2017-01-01
Introduction Sedentary behaviors such as sitting time are associated with obesity and diabetes independently of total reported physical activity. This study aimed to describe the current sitting time/day prevalence and trends and to examine the association of sitting time with sociodemographic and clinical variables in Mexico City. Methods Two cross-sectional representative surveys in Mexico City were used for this analysis (2006: n = 1148 and 2015: n = 1329). Sedentary behavior questions from the International Physical Activity Questionnaire included time spent sitting on a weekday in the last week or on a Wednesday. Sitting time /day was divided into deciles, and participants in the highest decile (≥ 420 minutes/day) were classified within the high sitting category; others were classified in the low sitting time category. Multivariate logistic regression was used to evaluate the associations of sitting time with sociodemographic and clinical indicators, controlling for confounders and testing for potential interactions. Results A total of 13.7% (2006) and 14.8% (2015) adults were classified in the highest sitting time category (≥ 420 minutes/day). There was a significant increase in the average sitting time/day between the surveys (216.0 minutes in 2006 vs. 233.3 minutes in 2015, p < 0.001). In 2015, men, those aged 20–49 years, those in low-intensity jobs, students, and those with a high socioeconomic level were more likely to be in the highest sitting time category. Participants with overweight/obesity (OR = 2.37, 95% CI: 1.11, 5.09) and those with high glucose levels (survey finding) (OR = 2.34, 95% CI: 1.04, 5.25) were more likely to report sitting time in the highest category. Discussion Sitting time/day prevalence increased 8%, and average daily sitting minutes significantly increased by 8.2% (18 minutes) in the nine-year study period (2006–2015). Current public health policies should consider strategies not only for increasing physical activity levels, but also for reducing sitting time/day among the population as a measure to fight the growing epidemic of obesity and diabetes in Mexico. PMID:29194458
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Gupta, Nidhi; Christiansen, Caroline Stordal; Hallman, David M; Korshøj, Mette; Carneiro, Isabella Gomes; Holtermann, Andreas
2015-01-01
Studies on the association between sitting time and low back pain (LBP) have found contrasting results. This may be due to the lack of objectively measured sitting time or because socioeconomic confounders were not considered in the analysis. To investigate the association between objectively measured sitting time (daily total, and occupational and leisure-time periods) and LBP among blue-collar workers. Two-hundred-and-one blue-collar workers wore two accelerometers (GT3X+ Actigraph) for up to four consecutive working days to obtain objective measures of sitting time, estimated via Acti4 software. Workers reported their LBP intensity the past month on a scale from 0 (no pain) to 9 (worst imaginable pain) and were categorized into either low (≤ 5) or high (> 5) LBP intensity groups. In the multivariate-adjusted binary logistic regression analysis, total sitting time, and occupational and leisure-time sitting were both modeled as continuous (hours/day) and categorical variables (i.e. low, moderate and high sitting time). The multivariate logistic regression analysis showed a significant positive association between total sitting time (per hour) and high LBP intensity (odds ratio; OR = 1.43, 95%CI = 1.15-1.77, P = 0.01). Similar results were obtained for leisure-time sitting (OR = 1.45, 95%CI = 1.10-1.91, P = 0.01), and a similar but non-significant trend was obtained for occupational sitting time (OR = 1.34, 95%CI 0.99-1.82, P = 0.06). In the analysis on categorized sitting time, high sitting time was positively associated with high LBP for total (OR = 3.31, 95%CI = 1.18-9.28, P = 0.03), leisure (OR = 5.31, 95%CI = 1.57-17.90, P = 0.01), and occupational (OR = 3.26, 95%CI = 0.89-11.98, P = 0.08) periods, referencing those with low sitting time. Sitting time is positively associated with LBP intensity among blue-collar workers. Future studies using a prospective design with objective measures of sitting time are recommended.
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Gupta, Nidhi; Christiansen, Caroline Stordal; Hallman, David M.; Korshøj, Mette; Carneiro, Isabella Gomes; Holtermann, Andreas
2015-01-01
Background Studies on the association between sitting time and low back pain (LBP) have found contrasting results. This may be due to the lack of objectively measured sitting time or because socioeconomic confounders were not considered in the analysis. Objectives To investigate the association between objectively measured sitting time (daily total, and occupational and leisure-time periods) and LBP among blue-collar workers. Methods Two-hundred-and-one blue-collar workers wore two accelerometers (GT3X+ Actigraph) for up to four consecutive working days to obtain objective measures of sitting time, estimated via Acti4 software. Workers reported their LBP intensity the past month on a scale from 0 (no pain) to 9 (worst imaginable pain) and were categorized into either low (≤5) or high (>5) LBP intensity groups. In the multivariate-adjusted binary logistic regression analysis, total sitting time, and occupational and leisure-time sitting were both modeled as continuous (hours/day) and categorical variables (i.e. low, moderate and high sitting time). Results The multivariate logistic regression analysis showed a significant positive association between total sitting time (per hour) and high LBP intensity (odds ratio; OR=1.43, 95%CI=1.15-1.77, P=0.01). Similar results were obtained for leisure-time sitting (OR=1.45, 95%CI=1.10-1.91, P=0.01), and a similar but non-significant trend was obtained for occupational sitting time (OR=1.34, 95%CI 0.99-1.82, P=0.06). In the analysis on categorized sitting time, high sitting time was positively associated with high LBP for total (OR=3.31, 95%CI=1.18-9.28, P=0.03), leisure (OR=5.31, 95%CI=1.57-17.90, P=0.01), and occupational (OR=3.26, 95%CI=0.89-11.98, P=0.08) periods, referencing those with low sitting time. Conclusion Sitting time is positively associated with LBP intensity among blue-collar workers. Future studies using a prospective design with objective measures of sitting time are recommended. PMID:25806808
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De Bourdeaudhuij, Ilse; Cardon, Greet; Vandelanotte, Corneel
2016-01-01
Background Effective interventions to influence workplace sitting are needed, as office-based workers demonstrate high levels of continued sitting, and sitting too much is associated with adverse health effects. Therefore, we developed a theory-driven, Web-based, interactive, computer-tailored intervention aimed at reducing and interrupting sitting at work. Objective The objective of our study was to investigate the effects of this intervention on objectively measured sitting time, standing time, and breaks from sitting, as well as self-reported context-specific sitting among Flemish employees in a field-based approach. Methods Employees (n=213) participated in a 3-group randomized controlled trial that assessed outcomes at baseline, 1-month follow-up, and 3-month follow-up through self-reports. A subsample (n=122) were willing to wear an activity monitor (activPAL) from Monday to Friday. The tailored group received an automated Web-based, computer-tailored intervention including personalized feedback and tips on how to reduce or interrupt workplace sitting. The generic group received an automated Web-based generic advice with tips. The control group was a wait-list control condition, initially receiving no intervention. Intervention effects were tested with repeated-measures multivariate analysis of variance. Results The tailored intervention was successful in decreasing self-reported total workday sitting (time × group: P<.001), sitting at work (time × group: P<.001), and leisure time sitting (time × group: P=.03), and in increasing objectively measured breaks at work (time × group: P=.07); this was not the case in the other conditions. The changes in self-reported total nonworkday sitting, sitting during transport, television viewing, and personal computer use, objectively measured total sitting time, and sitting and standing time at work did not differ between conditions. Conclusions Our results point out the significance of computer tailoring for sedentary behavior and its potential use in public health promotion, as the effects of the tailored condition were superior to the generic and control conditions. Trial Registration Clinicaltrials.gov NCT02672215; http://clinicaltrials.gov/ct2/show/NCT02672215 (Archived by WebCite at http://www.webcitation.org/6glPFBLWv) PMID:27245789
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Hadgraft, Nyssa T; Lynch, Brigid M; Clark, Bronwyn K; Healy, Genevieve N; Owen, Neville; Dunstan, David W
2015-09-15
Recent evidence links sedentary behaviour (or too much sitting) with poorer health outcomes; many adults accumulate the majority of their daily sitting time through occupational sitting and TV viewing. To further the development and targeting of evidence-based strategies there is a need for identification of the factors associated with higher levels of these behaviours. This study examined socio-demographic and health-related correlates of occupational sitting and of combined high levels of occupational sitting/TV viewing time amongst working adults. Participants were attendees of the third wave (2011/12) of the Australian Diabetes, Obesity and Lifestyle (AusDiab) study who worked full-time (≥35 h/week; n = 1,235; 38 % women; mean ± SD age 53 ± 7 years). Logistic and multinomial logistic regression analyses were conducted (separately for women and men) to assess cross-sectional associations of self-reported occupational sitting time (categorised as high/low based on the median) and also the combination of occupational sitting time/TV viewing time (high/low for each outcome), with a number of potential socio-demographic and health-related correlates. Higher levels of occupational sitting (>6 h/day) were associated with higher household income for both genders. Lower levels of occupational sitting were associated with being older (women only); and, for men only, having a blue collar occupation, having a technical/vocational educational attainment, and undertaking more leisure-time physical activity (LTPA). Attributes associated with high levels of both occupational sitting and TV viewing time included white collar occupation (men only), lower levels of LTPA (both genders), higher BMI (men), and higher energy consumption (women). Higher household income (both genders) and professional/managerial occupations (men only) were correlates of high occupational sitting time, relative to low occupational sitting time, while health-related factors (lower LTPA, higher BMI - men, and higher energy consumption - women) were associated with high levels of both occupational sitting and TV viewing time, relative to low occupational sitting and low TV viewing time. These findings suggest possible high-risk groups that may benefit from targeted interventions. Further research is needed on potentially modifiable environmental and social correlates of occupational sitting time, in order to inform workplace initiatives.
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Total and domain-specific sitting time among employees in desk-based work settings in Australia.
Bennie, Jason A; Pedisic, Zeljko; Timperio, Anna; Crawford, David; Dunstan, David; Bauman, Adrian; van Uffelen, Jannique; Salmon, Jo
2015-06-01
To describe the total and domain-specific daily sitting time among a sample of Australian office-based employees. In April 2010, paper-based surveys were provided to desk-based employees (n=801) in Victoria, Australia. Total daily and domain-specific (work, leisure-time and transport-related) sitting time (minutes/day) were assessed by validated questionnaires. Differences in sitting time were examined across socio-demographic (age, sex, occupational status) and lifestyle characteristics (physical activity levels, body mass index [BMI]) using multiple linear regression analyses. The median (95% confidence interval [CI]) of total daily sitting time was 540 (531-557) minutes/day. Insufficiently active adults (median=578 minutes/day, [95%CI: 564-602]), younger adults aged 18-29 years (median=561 minutes/day, [95%CI: 540-577]) reported the highest total daily sitting times. Occupational sitting time accounted for almost 60% of total daily sitting time. In multivariate analyses, total daily sitting time was negatively associated with age (unstandardised regression coefficient [B]=-1.58, p<0.001) and overall physical activity (minutes/week) (B=-0.03, p<0.001) and positively associated with BMI (B=1.53, p=0.038). Desk-based employees reported that more than half of their total daily sitting time was accrued in the work setting. Given the high contribution of occupational sitting to total daily sitting time among desk-based employees, interventions should focus on the work setting. © 2014 Public Health Association of Australia.
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Engelen, Lina; Gale, Joanne; Chau, Josephine Y; Hardy, Louise L; Mackey, Martin; Johnson, Nathan; Shirley, Debra; Bauman, Adrian
2017-04-01
To examine the associations of physical activity (PA) and sitting time (sit) with cardio-metabolic diseases. Cross-sectional data from the Australian National Nutrition and Physical Activity Survey 2011-2012 (n=9,435) were used to classify adults into low and high risk groups based on their physical activity and sitting behaviour profiles. Logistic regression models examined associations between low and high risk classifications (high PA-low sit; high PA-high sit; low PA-low sit; low PA-high sit;) and socio-demographic factors, and associations between low and high risk classifications and the prevalence of cardiovascular disease, Type 2 diabetes and metabolic syndrome. These results characterise chronic disease risk based on both physical activity and sitting behaviour. Adults with the highest risk lifestyle behaviour pattern (low PA-high sit) tended to be middle aged, male, at greater social disadvantage, smoke, report fair health, be abdominally obese and employed in administrative and driver occupations. These individuals had a substantially greater risk of cardiovascular disease and metabolic syndrome (OR=1.41, 95% CI 1.13, 1.75; OR= 2.37, 95% CI 1.63, 3.45, respectively). The findings highlight the importance of both sufficient physical activity and low sitting time for cardio-metabolic health. Implications for public health: Primary prevention focus should consider physical activity and reduced sitting time as well as provision of relevant advice for cardio-metabolic health. © 2017 The Authors.
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Do Sitting, Standing, or Treadmill Desks Impact Psychobiological Indicators of Work Productivity?
Gilson, Nicholas D; Hall, Caitlin; Renton, Angela; Ng, Norman; von Hippel, William
2017-10-01
This pilot study investigated the links between psychobiological indicators of work productivity, prolonged desk sitting, and conditions whereby office workers were able to interrupt sitting using a sit-stand or treadmill desk. Twenty participants visited our laboratory and completed their own desk work in counterbalanced sit-only, sit-stand (Varidesk Pro Plus 48™), and sit-walk conditions (Infiniti TR1200-DTS™). Steady-state visually evoked potentials calculated from electroencephalography recordings during a set task at the end of the workday assessed attentional resource. Salivary cortisol samples were taken during the morning and afternoon to measure stress response. Within-subject analyses were used to compare work productivity indicators relative to condition. No significant differences in mean steady-state visually evoked potential amplitude were observed, although attentional resource allocation was found to be the most effective following the sit-stand [1.01 (0.46) μV] compared with the sit-walk [0.9 (0.28) μV] and sit-only [0.91 (0.32) μV] conditions. The mean magnitude of decrease in cortisol was most apparent when workers used treadmill (1.5 nmol/L; P = .007) and sit-stand (1.6 nmol/L; P = .001) desks, and least evident in the sit-only condition (1.0 nmol/L; P = .146). The findings highlight the potential benefits of standing or active deskwork to the allocation of attentional resources and the regulation of stress.
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Electrical structure of Newberry Volcano, Oregon
Fitterman, D.V.; Stanley, W.D.; Bisdorf, R.J.
1988-01-01
From the interpretation of magnetotelluric, transient electromagnetic, and Schlumberger resistivity soundings, the electrical structure of Newberry Volcano in central Oregon is found to consist of four units. From the surface downward, the geoelectrical units are 1) very resistive, young, unaltered volcanic rock, (2) a conductive layer of older volcanic material composed of altered tuffs, 3) a thick resistive layer thought to be in part intrusive rocks, and 4) a lower-crustal conductor. This model is similar to the regional geoelectrical structure found throughout the Cascade Range. Inside the caldera, the conductive second layer corresponds to the steep temperature gradient and alteration minerals observed in the USGS Newberry 2 test-hole. Drill hole information on the south and north flanks of the volcano (test holes GEO N-1 and GEO N-3, respectively) indicates that outside the caldera the conductor is due to alteration minerals (primarily smectite) and not high-temperature pore fluids. On the flanks of Newberry the conductor is generally deeper than inside the caldera, and it deepens with distance from the summit. A notable exception to this pattern is seen just west of the caldera rim, where the conductive zone is shallower than at other flank locations. The volcano sits atop a rise in the resistive layer, interpreted to be due to intrusive rocks. -from Authors
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Crystal Structure of the Eukaryotic Origin Recognition Complex
Bleichert, Franziska; Botchan, Michael R.; Berger, James M.
2015-01-01
Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset. The 3.5 Å resolution crystal structure of Drosophila ORC reveals that the 270 kDa initiator core complex comprises a two-layered notched ring in which a collar of winged-helix domains from the Orc1-5 subunits sits atop a layer of AAA+ ATPase folds. Although canonical inter-AAA+ domain interactions exist between four of the six ORC subunits, unanticipated features are also evident, including highly interdigitated domain-swapping interactions between the winged-helix folds and AAA+ modules of neighboring protomers, and a quasi-spiral arrangement of DNA binding elements that circumnavigate a ~20 Å wide channel in the center of the complex. Comparative analyses indicate that ORC encircles DNA, using its winged-helix domain face to engage the MCM2-7 complex during replicative helicase loading; however, an observed >90° out-of-plane rotation for the Orc1 AAA+ domain disrupts interactions with catalytic amino acids in Orc4, narrowing and sealing off entry into the central channel. Prima facie, our data indicate that Drosophila ORC can switch between active and autoinhibited conformations, suggesting a novel means for cell cycle and/or developmental control of ORC functions. PMID:25762138
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Collin, S M; Granell, R; Westgarth, C; Murray, J; Paul, E; Sterne, J A C; John Henderson, A
2015-01-01
Studies have shown an inverse association of pet ownership with allergy but inconclusive findings for asthma. To investigate whether pet ownership during pregnancy and childhood was associated with asthma and atopy at the age of 7 in a UK population-based birth cohort. Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to investigate associations of pet ownership at six time points from pregnancy to the age of 7 with asthma, atopy (grass, house dust mite, and cat skin prick test) and atopic vs. non-atopic asthma at the age of 7 using logistic regression models adjusted for child's sex, maternal history of asthma/atopy, maternal smoking during pregnancy, and family adversity. A total of 3768 children had complete data on pet ownership, asthma, and atopy. Compared with non-ownership, continuous ownership of any pet (before and after the age of 3) was associated with 52% lower odds of atopic asthma [odds ratio (OR) 0.48, 95% CI 0.34-0.68]. Pet ownership tended to be associated with increased risk of non-atopic asthma, particularly rabbits (OR 1.61, 1.04-2.51) and rodents (OR 1.86, 1.15-3.01), comparing continuous vs. non-ownership. Pet ownership was consistently associated with lower odds of sensitization to grass, house dust mite, and cat allergens, but rodent ownership was associated with higher odds of sensitization to rodent allergen. Differential effects of pet ownership on atopic vs. non-atopic asthma were evident for all pet types. Pet ownership during pregnancy and childhood in this birth cohort was consistently associated with a reduced risk of aeroallergen sensitization and atopic asthma at the age of 7, but tended to be associated (particularly for rabbits and rodents) with an increased risk of non-atopic asthma. The opposing effects on atopy vs. non-atopic asthma might be considered by parents when they are deciding whether to acquire a pet. © 2014 John Wiley & Sons Ltd.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Sulkosky, V.; Jin, G.; Long, E.
Background: Measurements of the neutron charge form factor, Gmore » $$n\\atop{E}$$, are challenging because the neutron has no net charge. Additionally, measurements of the neutron form factors must use nuclear targets which require accurately accounting for nuclear effects. Extracting G$$n\\atop{E}$$ with different targets and techniques provides an important test of our handling of these effects. Purpose: The goal of the measurement was to use an inclusive asymmetry measurement technique to extract the neutron charge form factor at a four-momentum transfer of 1 (GeV/c) 2. This technique has very different systematic uncertainties than traditional exclusive measurements and thus serves as an independent check of whether nuclear effects have been taken into account correctly. Method: The inclusive quasielastic reaction 3$$→\\atop{He}$$ ($$→\\atop{e}$$, e') was measured at Jefferson Laboratory. The neutron electric form factor, G$$n\\atop{E}$$, was extracted at Q 2 = 0.98 ( GeV/c) 2 from ratios of electron-polarization asymmetries measured for two orthogonal target spin orientations. This Q 2 is high enough that the sensitivity to G$$n\\atop{E}$$ is not overwhelmed by the neutron magnetic contribution, and yet low enough that explicit neutron detection is not required to suppress pion production. Results: The neutron electric form factor, G$$n\\atop{E}$$, was determined to be 0.0414 ± 0.0077 ( stat ) ± 0.0022 ( syst ), providing the first high-precision inclusive extraction of the neutron's charge form factor. In conclusion: The use of the inclusive quasielastic 3$$→\\atop{He}$$ ($$→\\atop{e}$$, e') with a four-momentum transfer near 1 (GeV/c) 2 has been used to provide a unique measurement of G$$n\\atop{E}$$. This new result provides a systematically independent validation of the exclusive extraction technique results and implies that the nuclear corrections are understood. This is contrary to the proton form factor where asymmetry and differential cross section measurements have been shown to have large systematic differences.« less
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Sulkosky, V.; Jin, G.; Long, E.; ...
2017-12-26
Background: Measurements of the neutron charge form factor, Gmore » $$n\\atop{E}$$, are challenging because the neutron has no net charge. Additionally, measurements of the neutron form factors must use nuclear targets which require accurately accounting for nuclear effects. Extracting G$$n\\atop{E}$$ with different targets and techniques provides an important test of our handling of these effects. Purpose: The goal of the measurement was to use an inclusive asymmetry measurement technique to extract the neutron charge form factor at a four-momentum transfer of 1 (GeV/c) 2. This technique has very different systematic uncertainties than traditional exclusive measurements and thus serves as an independent check of whether nuclear effects have been taken into account correctly. Method: The inclusive quasielastic reaction 3$$→\\atop{He}$$ ($$→\\atop{e}$$, e') was measured at Jefferson Laboratory. The neutron electric form factor, G$$n\\atop{E}$$, was extracted at Q 2 = 0.98 ( GeV/c) 2 from ratios of electron-polarization asymmetries measured for two orthogonal target spin orientations. This Q 2 is high enough that the sensitivity to G$$n\\atop{E}$$ is not overwhelmed by the neutron magnetic contribution, and yet low enough that explicit neutron detection is not required to suppress pion production. Results: The neutron electric form factor, G$$n\\atop{E}$$, was determined to be 0.0414 ± 0.0077 ( stat ) ± 0.0022 ( syst ), providing the first high-precision inclusive extraction of the neutron's charge form factor. In conclusion: The use of the inclusive quasielastic 3$$→\\atop{He}$$ ($$→\\atop{e}$$, e') with a four-momentum transfer near 1 (GeV/c) 2 has been used to provide a unique measurement of G$$n\\atop{E}$$. This new result provides a systematically independent validation of the exclusive extraction technique results and implies that the nuclear corrections are understood. This is contrary to the proton form factor where asymmetry and differential cross section measurements have been shown to have large systematic differences.« less
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Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children.
Contreras, J Paola; Ly, Ngoc P; Gold, Diane R; He, Hongzhen; Wand, Mathew; Weiss, Scott T; Perkins, David L; Platts-Mills, Thomas A E; Finn, Patricia W
2003-12-01
The early childhood allergen-induced immune responses associated with atopic disease and IgE production in early life are not well understood. We assessed the relationship of allergen-induced cytokine production by PBMCs to both atopic disease and to IgE increase in a cohort of children with a parental history of allergy or asthma (n = 112) at a median of 2 years of age. We examined cockroach (Bla g 1)-induced, house dust mite (Der f 1)-induced, and cat (Fel d 1)-induced cytokine secretion, including secretion of IFN-gamma, IL-13, IL-10, and TNF-alpha. We investigated whether distinct cytokine patterns associated with atopic disease can be detected in immune responses of children. PBMCs were isolated, and allergen-induced cytokine secretion was analyzed by means of ELISA. Atopic disease was defined as physician- or nurse-diagnosed eczema or hay fever. Increased IgE was defined as an IgE level of greater than 35 U/mL to dust mite, cockroach, cat, and egg white or a total IgE level of 60 U/mL or greater. Compared with children without atopic disease, children with atopic disease had lower Der f 1 (P =.005) and Bla g 2 (P =.03) allergen-induced IFN-gamma levels. Compared with children without increased IgE (n = 95), those with increased IgE (n = 16) had higher Der f 1-induced (P =.006) and Fel d 1-induced (P =.005) IL-13 levels and lower Bla g 2-induced (P =.03) IFN-gamma levels. Compared with children with neither atopic disease nor repeated wheeze, children with both atopic disease and repeated wheeze had lower levels of allergen-induced IFN-gamma (P =.01 for Der f 1 and P =.02 for Bla g 2) cytokine secretion. In young children at risk for asthma or allergy, decreased allergen-induced IFN-gamma secretion is associated with atopic disease and, in some cases, with increased IgE levels. Increased allergen-induced IL-13 secretion is most strongly associated with early life increase of IgE.
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Collin, S.M.; Granell, R; Westgarth, C; Murray, J; Paul, E; Sterne, J.A.C.; Henderson, A. John
2014-01-01
Background Studies have shown an inverse association of pet ownership with allergy but inconclusive findings for asthma. Objective To investigate whether pet ownership during pregnancy and childhood was associated with asthma and atopy at age 7 years in a UK population-based birth cohort. Methods Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to investigate associations of pet ownership at six time-points from pregnancy to age 7 years with asthma, atopy (grass, house-dust mite, and cat skin prick test) and atopic versus non-atopic asthma at age 7 years using logistic regression models adjusted for child's sex, maternal history of asthma/atopy, maternal smoking during pregnancy and family adversity. Results 3,768 children had complete data on pet ownership, asthma and atopy. Compared with non-ownership, continuous ownership of any pet (before and after age 3 years) was associated with 52% lower odds of atopic asthma (odds ratio [OR] 0.48, 95% CI 0.34–0.68). Pet ownership tended to be associated with increased risk of non-atopic asthma, particularly rabbits (OR 1.61, 1.04–2.51) and rodents (OR 1.86, 1.15–3.01), comparing continuous versus non-ownership. Pet ownership was consistently associated with lower odds of sensitization to grass, house-dust mite and cat allergens, but rodent ownership was associated with higher odds of sensitization to rodent allergen. Differential effects of pet ownership on atopic versus non-atopic asthma were evident for all pet types. Conclusions Pet ownership during pregnancy and childhood in this birth cohort was consistently associated with a reduced risk of aeroallergen sensitization and atopic asthma at age 7 years, but tended to be associated (particularly for rabbits and rodents) with an increased risk of non-atopic asthma. Clinical relevance The opposing effects on atopy versus non-atopic asthma might be considered by parents when they are deciding whether to acquire a pet. PMID:25077415
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Ionic liquids as antimicrobials, solvents, and prodrugs for treating skin disease
NASA Astrophysics Data System (ADS)
Zakrewsky, Michael A.
The skin is the largest organ in the body. It provides a compliant interface for needle-free drug delivery, while avoiding major degradative pathways associated with the GI tract. These can result in improved patient compliance and sustained and controlled release compared to other standard delivery methods such as intravenous injection, subcutaneous injection, and oral delivery. Concurrently, for the treatment of skin related diseases (e.g. bacterial infection, skin cancer, psoriasis, atopic dermatitis, etc.) cutaneous application provides targeted delivery to the disease site, allowing the use of more potent therapeutics with fewer systemic side effects. Unfortunately, the outer layer of the skin -- the stratum corneum (SC) -- presents a significant barrier to most foreign material. This is particularly true for large hydrophilic molecules (>500Da), which must partition through tortuous lipid channels in the SC to penetrate deep tissue layers where the majority of skin-related diseases reside. Interestingly, over the last few decades ionic liquids (ILs) have emerged as a burgeoning class of designer solvents. ILs have been proven beneficial for use in industrial processing, catalysis, pharmaceuticals, and electrochemistry to name a few. The ability to modulate either the cation or anion individually presents an advantageous framework for tuning secondary characteristics without sacrificing the primary function of the IL. Here we report the use of novel ILs for cutaneous drug delivery. Specifically, we demonstrate their potential as potent, broad-spectrum antimicrobials, as solvents for topical delivery of hydrophilic and hydrophobic drugs, and as prodrugs to either reduce the dose-dependent toxicity of drugs that cause skin irritation or enhance delivery of macromolecules into skin and cells. Thus, our results clearly demonstrate ILs holds promise as a transformative platform for treating skin disease.
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M&A For Lithography Of Sparse Arrays Of Sub-Micrometer Features
Brueck, Steven R.J.; Chen, Xiaolan; Zaidi, Saleem; Devine, Daniel J.
1998-06-02
Methods and apparatuses are disclosed for the exposure of sparse hole and/or mesa arrays with line:space ratios of 1:3 or greater and sub-micrometer hole and/or mesa diameters in a layer of photosensitive material atop a layered material. Methods disclosed include: double exposure interferometric lithography pairs in which only those areas near the overlapping maxima of each single-period exposure pair receive a clearing exposure dose; double interferometric lithography exposure pairs with additional processing steps to transfer the array from a first single-period interferometric lithography exposure pair into an intermediate mask layer and a second single-period interferometric lithography exposure to further select a subset of the first array of holes; a double exposure of a single period interferometric lithography exposure pair to define a dense array of sub-micrometer holes and an optical lithography exposure in which only those holes near maxima of both exposures receive a clearing exposure dose; combination of a single-period interferometric exposure pair, processing to transfer resulting dense array of sub-micrometer holes into an intermediate etch mask, and an optical lithography exposure to select a subset of initial array to form a sparse array; combination of an optical exposure, transfer of exposure pattern into an intermediate mask layer, and a single-period interferometric lithography exposure pair; three-beam interferometric exposure pairs to form sparse arrays of sub-micrometer holes; five- and four-beam interferometric exposures to form a sparse array of sub-micrometer holes in a single exposure. Apparatuses disclosed include arrangements for the three-beam, five-beam and four-beam interferometric exposures.
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Choi, Won Jun; Ko, Joo Yeon; Kim, Jin Wou; Lee, Kwang Hoon; Park, Chun Wook; Kim, Kyu Han; Kim, Myeung Nam; Lee, Ai Young; Cho, Sang Hyun; Park, Young Lip; Choi, Jee Ho; Seo, Seong Jun; Lee, Yang Won; Roh, Joo Young; Park, Young Min; Kim, Dong Jae; Ro, Young Suck
2012-09-01
The aims of this study were to evaluate the prevalence, severity and risk factors for atopic dermatitis in Korean pre-school children as determined by dermatological examination vs questionnaire survey. A total of 6,453 pre-school children from 59 kindergartens and 14 day-care centres were evaluated. Parents responded to an International Study of Asthma and Allergies in Childhood (ISAAC)-based questionnaire containing questions concerning 23 risk factors, as well as the prevalence, and severity of atopic dermatitis. Fourteen dermatologists then examined the participants according to the Korean diagnostic criteria for atopic dermatitis, and the Eczema Area and Severity Index (EASI) score. Atopic dermatitis prevalence determined by dermatological examination was lower than the questionnaire-based prevalence (9.2% vs 19.1%). Most patients (96.2%) had mild atopic dermatitis according to the EASI score (mean ± SD 3.91 ± 4.73; median 1.5; range 0.2-38.0). However, 17.4% had sleep disturbance, and 56.7% had not obtained complete remission of their rash over the previous 12 months. Among the 12 risk factors, "changing the patient's house to a newly built house during the first year of life" had significant odds ratio. In conclusion, the prevalence of atopic dermatitis in Korea in the ISAAC-based survey conducted by paediatricians was similar to that in several European countries, and lower than the 2006 Korean figure (28.9%). In addition, the prevalence of atopic dermatitis was lower when assessed by dermatological examination than by questionnaire.
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Acute health effects of urban fine and ultrafine particles on children with atopic dermatitis.
Song, Sanghwan; Lee, Kiyoung; Lee, Young-Mi; Lee, Jung-Hyun; Lee, Sang Il; Yu, Seung-Do; Paek, Domyung
2011-04-01
Although ambient particulate pollutants have been shown to exacerbate existing allergic symptoms of mucous membranes including rhinitis and asthma, the effects on skin such as atopic dermatitis in childhood deserve further study. We investigated the effects of urban particulate pollutants including ultrafine particles on atopic severity in children with atopic dermatitis. We included 41 schoolchildren, 8-12 years old, who had been diagnosed with atopic dermatitis. For 67 consecutive days, all of them measured their symptoms in a diary. To assess exposure, the daily ambient mass concentrations of particulate matter less than 10, 2.5 and 1 μm (PM(10), PM(2.5) and PM(1), respectively) and concentrations of submicron particles (0.01- 1 μm) were measured at a local school. The mean mass concentrations of PM(10), PM(2.5) and PM(1) were 74.0, 57.8 and 50.8 μg/m(3), respectively. The mean concentrations were 41,335/cm(3) ultrafine particles (UFPs) and 8577/cm(3) accumulation mode (0.1-1 μm) particles. Significant associations were found between the concentrations of ultrafine particles and the itchiness symptom in children with atopic dermatitis. An interquartile range (IQR) increase in previous day ultrafine particles concentration (IQR: 28-140/m(3)) was significantly associated with a 3.1% (95% confidence interval, 0.2-6.1) increase in the itch symptom score for children with atopic dermatitis. The results suggested that the concentration of ambient ultrafine particles may exacerbate skin symptoms in children with atopic dermatitis. Copyright © 2011. Published by Elsevier Inc.
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Japanese Guideline for Atopic Dermatitis 2014.
Katayama, Ichiro; Kohno, Yoichi; Akiyama, Kazuo; Aihara, Michiko; Kondo, Naomi; Saeki, Hidehisa; Shoji, Shunsuke; Yamada, Hidekazu; Nakamura, Koichiro
2014-09-01
Given the importance of appropriate diagnosis and appropriate assessment of cutaneous symptoms in treatment of atopic dermatitis, the basics of treatment in this guideline are composed of (1) investigation and countermeasures of causes and exacerbating factors, (2) correction of skin dysfunctions (skin care), and (3) pharmacotherapy, as three mainstays. These are based on the disease concept that atopic dermatitis is a inflammatory cutaneous disease with eczema by atopic diathesis, multi-factorial in onset and aggravation, and accompanied by skin dysfunctions. These three points are equally important and should be appropriately combined in accordance with the symptoms of each patient. In treatment, it is important to transmit the etiological, pathological, physiological, or therapeutic information to the patient to build a favorable partnership with the patient or his/her family so that they may fully understand the treatment. This guideline discusses chiefly the basic therapy in relation to the treatment of this disease. The goal of treatment is to enable patients to lead an uninterrupted social life and to control their cutaneous symptoms so that their quality of life (QOL) may meet a satisfactory level. The basics of treatment discussed in this guideline are based on the "Guidelines for the Treatment of Atopic Dermatitis 2008" prepared by the Health and Labour Sciences Research and the "Guidelines for the Management of Atopic Dermatitis 2012 (ADGL2012)" prepared by the Atopic Dermatitis Guidelines Advisory Committee, Japanese Society of Allergology in principle. The guidelines for the treatment of atopic dermatitis are summarized in the "Japanese Guideline for the Diagnosis and Treatment of Allergic Disease 2013" together with those for other allergic diseases.
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Kim, Seong Hee; Lee, Jae Ho; Ly, Sun Yung
2016-12-01
Atopic dermatitis is one of the most common pediatric chronic inflammatory skin diseases, and certain food allergens and nutrients are closely related to the development and severity of atopic dermatitis. While avoidance of the causative foods is considered the mainstay of treatment, unverified excessive restriction might induce unnecessary limitations in the food intake, consequently leading to nutritional deficiencies and poor growth. This study aimed to identify the characteristics and nutrient intake status in children with atopic dermatitis and to investigate the effects of individualized nutrition intervention. We retrospectively reviewed electronic medical records of 77 pediatric patients with atopic dermatitis who received 4 months of individualized nutrition intervention combined with an elimination diet. The patient characteristics, nutrient intake status, and clinical status were examined before and after the intervention. Before the intervention, 5 children had a weight for height z-score below -2.0, and 48.1% had experienced food restriction; these children showed a significantly higher SCORing of Atopic Dermatitis index than those without experiences, with the number of restricted foods before the intervention positively correlating with the disease severity. The intakes of n-6 and n-3 fatty acids, calcium, folate, and vitamin D were lower than the recommended nutrient intakes for Koreans. After the intervention, the weight for height z-score of 35 children was significantly increased and their SCORing of Atopic Dermatitis index was significantly reduced (p<0.05). Individualized nutrition intervention appears useful for alleviating the severity of atopic dermatitis and improving the growth status by improving the nutrient intake.
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Kahr, Niklas; Naeser, Vibeke; Stensballe, Lone Graff; Kyvik, Kirsten Ohm; Skytthe, Axel; Backer, Vibeke; Bønnelykke, Klaus; Thomsen, Simon Francis
2015-01-01
The development of atopic diseases early in life suggests an important role of perinatal risk factors. To study whether early-life exposures modify the genetic influence on atopic diseases in a twin population. Questionnaire data on atopic diseases from 850 monozygotic and 2279 like-sex dizygotic twin pairs, 3-9 years of age, from the Danish Twin Registry were cross-linked with data on prematurity, Cesarean section, maternal age at birth, parental cohabitation, season of birth and maternal smoking during pregnancy, from the Danish National Birth Registry. Significant predictors of atopic diseases were identified with logistic regression and subsequently tested for genetic effect modification using variance components analysis. After multivariable adjustment, prematurity (gestational age below 32 weeks) [odds ratio (OR) = 1.93, confidence interval (CI) = 1.45-2.56], Cesarean section (OR = 1.25, CI = 1.05-1.49) and maternal smoking during pregnancy (OR = 1.70, CI = 1.42-2.04) significantly influenced the risk of asthma, whereas none of the factors were significantly associated with atopic dermatitis and hay fever. Variance components analysis stratified by exposure status showed no significant change in the heritability of asthma according to the identified risk factors. In this population-based study of children, there was no evidence of genetic effect modification of atopic diseases by several identified early-life risk factors. The causal relationship between these risk factors and atopic diseases may therefore be mediated via mechanisms different from gene-environment interaction. © 2014 John Wiley & Sons Ltd.
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Shafiei, Alireza; Moin, Mostafa; Pourpak, Zahra; Gharagozlou, Mohammad; Aghamohammadi, Asghar; Aghamohamadi, Asghar; Sajedi, Vahid; soheili, Habib; Sotoodeh, Soheila; Movahedi, Masoud
2011-03-01
Despite preliminary evidence, the role of probiotic and synbiotic in treatment of the atopic dermatitis has shown varying results. We aimed to evaluate whether synbiotic supplementation decrease severity of atopic dermatitis (AD) in childhood. In a randomized double blind-placebo controlled trial, we evaluated the synbiotic supplementation efficiency on the treatment of atopic dermatitis. Infants aged 1-36 months with moderate to severe atopic dermatitis were randomized (n=41) and received either synbiotic (probiotic plus prebiotic) (n=20) or placebo (n=21) daily as a powder for two months. Emollient (Eucerin) and topical corticosteroid (Hydrocortisone) were permitted. Children were scored for severity of atopic dermatitis (SCORAD). Also allergen Skin Prick Tests (SPT), IgE blood level and eosinophil count were measured at first visit. Patients' SCORAD were reevaluated at the end of intervention. We followed 36 out of 41 subjects for two months (drop out rate = 9%). In the whole group, the mean Total SCORAD (at base line 40.93) decreased by 56% (p=0.00). The mean Objective SCORAD (at base line 31.29) decreased by 53% (p=0.00). There was no significant difference in the mean decrease of total SCORAD between placebo (22.3) and synbiotic groups (24.2). There was also no difference between two intervention groups in the mean decrease of total SCORAD regarding to different demographic, clinical and para clinical subgroups. This study could not confirm synbiotic as an effective treatment for childhood atopic dermatitis and further studies are needed. These findings challenge the role of synbiotics in the treatment of childhood atopic dermatitis.
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Patch-test reaction patterns in patients with a predisposition to atopic dermatitis.
Brasch, Jochen; Schnuch, Axel; Uter, Wolfgang
2003-10-01
Patients with a predisposition to atopic dermatitis often need to be patch tested in order to detect possible contact sensitization. However, it is unknown whether immunologic or other peculiarities of atopic skin are related to altered patch-test reaction patterns. Our study was aimed at answering this question, because patch-test reaction patterns are of considerable practical importance in the reading and interpretation of patch tests. Therefore, we compared patterns of patch-test reactions in patients with a predisposition to atopic dermatitis and in control patients matched for sex, age, reason for testing and test centre. Patch-test results from 9 centres (2322 patients with a disposition to atopic dermatitis and 2126 matched controls) were evaluated retrospectively. All patients were tested with nickel sulfate, fragrance mix, potassium dichromate, lanolin alcohol, formaldehyde and mercury ammonium chloride. Patch tests applied for 1 day with readings on days 1, 2 and 3 were evaluated in order to cover the early phase of the reactions. Not unexpectedly, we found that, compared to the matched controls, patients with a predisposition to atopic dermatitis tended to have more doubtful and irritant reactions on day 1. As a new observation, it turned out that they had less reactions of crescendo pattern and more strong reactions on day 3. All these differences were slight/insignificant. A higher skin irritability in patients with a predisposition to atopic dermatitis is a likely explanation. In conclusion, standard methods for patch testing can be applied in patients with a predisposition to atopic dermatitis, but minor differences in reaction patterns should be considered.
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Age-related T cell responses to allergens in childhood.
Smart, J M; Suphioglu, C; Kemp, A S
2003-03-01
T cell priming, as determined by allergen-induced proliferative responses, is believed to occur principally in early childhood in both atopic and non-atopic infants under the influence of multiple factors including environmental allergen exposure. It is considered that T cell priming with expansion of Th2 cells is a crucial factor in the development of atopic disease. To examine T cell priming to commonly encountered allergens in childhood in relation to age. In a cross-sectional study T cell proliferation in relation to age was examined for three common allergens, ovalbumin (OVA), house dust mite (HDM) and rye grass pollen (RYE), in atopic and non-atopic children. The effect of age on Th1 (IFN-gamma) and Th2 (IL-5 and IL-13) cytokine production in response to these allergens was investigated to examine the possibility of immune deviation with time. A significant increase in T cell proliferation with age was observed with RYE among atopic children only. However, the same was not observed with the two other allergens studied (i.e. OVA and HDM). In addition, RYE-induced (but not HDM or OVA) cytokine production showed an increased Th2 deviation with age as reflected in the increasing IL-5/IFN-gamma and IL-13/IFN-gamma ratios only among the atopic subjects with rye grass pollen sensitivity. These findings suggest that grass pollen sensitivity in childhood is accompanied by a progressive accumulation of allergen-primed T cells and progressive deviation of the allergen-induced cytokine response towards a Th2 response in atopic subjects throughout childhood.
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NASA Astrophysics Data System (ADS)
Sun, M.; Bezada, M.
2017-12-01
Intermediate-depth seismicity outside active subduction zones is rare. However, there is a well-known occurrence of such events in a N-S elongated volume between Spain and Morocco, within what most researchers consider to be the relic Alboran slab. Partial subduction of, and tearing from the adjoining continental lithosphere have been suggested in this area. We investigate whether dehydration embrittlement or shear instability is more consistent with the Alboran intermediate depth seismicity by considering their location relative to the expected thermal structure and expected areas of high strain rate associated with thinning or tearing of the slab. We use a dense temporary seismograph deployment in Spain and Morocco to relocate 65 intermediate-depth events occurring between 2010 and 2013 in this region. The relocation procedure is realized by a grid-search approach that minimizes the normalized misfit between the picked times and travel times calculated using a regional 3D velocity model. Results indicate that, compared with catalog results, hypocenters after relocation are more concentrated in space; they tend to shift southward and eastward while no systematic shift in depth is observed. Relocated hypocenters concentrate at a depth range between 50-100 km and along a narrow longitude range around 4.5W. Investigation of the earthquake density distribution indicates these earthquakes concentrate into several clusters. One such cluster sits above the spain-arm of the Alboran slab and beneath the Spain continental lithosphere, indicating that it is likely associated to the thinning process of the Alboran slab. The other four clusters all lie within the interior of the slab. Interestingly, two of them are near the middle of the subducted lithosphere and the other two lie near its base. This observation seems at odds with expectations based on the two leading hypotheses for enabling brittle failure at intermediate depths.
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Cross-sectional Examination of Long-term Access to Sit-Stand Desks in a Professional Office Setting.
Carr, Lucas J; Swift, Maggie; Ferrer, Alex; Benzo, Roberto
2016-01-01
Prolonged sedentary behavior is an independent risk factor for many negative health outcomes. Although many employers have begun introducing sit-stand desks as means of reducing employee's occupational sitting time, few studies have examined the impact of prolonged access to such desks on sitting/standing time or cardiometabolic outcomes. The present study compared occupational sedentary/physical activity behaviors and cardiometabolic biomarkers among employees with long-term access to traditional sitting and sit-stand desks. This study used a naturalistic, cross-sectional study design. Occupational sedentary and physical activity behaviors and cardiometabolic health outcomes were collected in a controlled laboratory between February and June 2014. Data were analyzed in September 2014. Adults working in full-time sedentary desk jobs who reported having either a sit-stand desk (n=31) or standard sitting desk (n=38) for a minimum of 6 months were recruited. Employees with sit-stand desks sat less (p=0.02) and stood more at work (p=0.01) compared with employees with sitting desks. Significant inverse correlations were observed between several occupational physical activity outcomes (walking time, steps at work) and cardiometabolic risk factors (systolic blood pressure, weight, lean mass, BMI) over the entire sample. Employees with long-term access to sit-stand desks sat less and stood more compared with employees with sitting desks. These findings hold public health significance, as sit-stand desks represent a potentially sustainable approach for reducing sedentary behavior among the large, growing number of sedentary workers at increased risk for sedentariness-related pathologies. Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
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Why Women Sit: Determinants of Leisure Sitting Time for Working Women.
Walsh, Shana M; Umstattd Meyer, M Renée; Stamatis, Andreas; Morgan, Grant B
2015-01-01
Sedentary behavior is associated with negative health consequences independent of physical activity levels. Evidence suggests the work environment promotes sedentary behavior regardless of sector, and that employees with occupations requiring longer sitting times differ only marginally in leisure sitting time from those with more active occupations. Because physical activity opportunities may be limited across many work settings, leisure sedentary time may be more easily replaced with physical activity. Understanding correlates of leisure sedentary behaviors could inform interventions, specifically for women who are among the least active in America. Female employees at two universities completed online surveys (n = 156; mean age, 45.12 [SD = 12.5]; mean BMI, 26.7 kg/m(2) [SD = 5.9]; mean work hours/week, 43.7 [SD = 9.4]). Bivariate correlations and two hierarchical regression analyses were conducted to examine personal and behavioral correlates of weekday and weekend leisure sitting time. Final regression models revealed that greater weekday leisure sitting time (R(2) = 0.307) was related with being older (p = .006), having fewer children (p = .001), self-reporting poorer health (p = .006), and greater weekend sitting time (p < .001). Greater weekend leisure sitting time (R(2) = 0.261) was related with greater work-related sitting time (p = .020) and greater weekday leisure sitting time (p < .001). Physical activity was not related with weekday or weekend leisure sitting time. The most prominent correlates of leisure sitting time were other types of sedentary behaviors. This suggests that sedentary time in one segment of life predicts time spent sitting in other areas of life. Future interventions should target decreasing sedentary behaviors during leisure time specifically, in addition to increasing physical activity behavior. Copyright © 2015 Jacobs Institute of Women's Health. Published by Elsevier Inc. All rights reserved.
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Work engagement and its association with occupational sitting time: results from the Stormont study.
Munir, Fehmidah; Houdmont, Jonathan; Clemes, Stacy; Wilson, Kelly; Kerr, Robert; Addley, Ken
2015-01-29
Evidence suggests that poor health outcomes and poor work-related health outcomes such as sickness presenteeism are associated with excessive sitting at work. Studies have yet to investigate the relationship between work engagement and occupational sitting. Work engagement is considered to be an important predictor of work-related well-being. We investigated the relationship between and self-reported work engagement and high occupational sitting time in Northern Ireland Civil Service (NICS) office-based workers. A cohort of 4436 NICS office-workers (1945 men and 2491 women) completed a questionnaire measuring work engagement and occupational sitting time. Logistic regression analyses were used to test the associations between work engagement and occupational sitting times. Compared to women, men reported lower mean occupational sitting time (385.7 minutes/day; s.d. = 1.9; versus 362.4 minutes/day; s.d. =2.5; p < .0001). After adjusting for confounding variables, men with high work engagement of vigor (OR = 0.49, 95% CI 0.34-0.98) and dedication (OR 0.68 95% CI 0.47-0.98) were less likely to have prolonged sitting time. Women with high work engagement of vigor (OR = 0.62, 95% CI 0.45-0.84) were also less likely to have prolonged occupational sitting times. In contrast, women with high absorption (OR = 1.29, 95% CI 1.01-1.65) were more likely to have prolonged sitting times. Being actively engaged in one's work is associated with lower occupational sitting times for men (vigor and dedication) and to a limited extent for women (vigor only). This suggests that interventions such as introducing sit-stand workstations to reduce sitting times, may be beneficial for work engagement.
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Bensignor, Emmanuel
2010-10-01
Canine atopic dermatitis is an inflammatory skin disease characterized by typical clinical signs and affecting up to 10 % of dogs aged from 1 to 3 years. The diagnosis is mainly clinical and the treatment is complex. This canine form may offer a good model of human atopic dermatitis, as the two diseases show many pathogenetic, clinical and therapeutic similarities.
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Apgar Score Is Related to Development of Atopic Dermatitis: Cotwin Control Study
Naeser, Vibeke; Kahr, Niklas; Stensballe, Lone Graff; Kyvik, Kirsten Ohm; Skytthe, Axel; Backer, Vibeke
2013-01-01
Aim. To study the impact of birth characteristics on the risk of atopic dermatitis in a twin population. Methods. In a population-based questionnaire study of 10,809 twins, 3–9 years of age, from the Danish Twin Registry, we identified 907 twin pairs discordant for parent-reported atopic dermatitis. We cross-linked with data from the Danish National Birth Registry and performed cotwin control analysis in order to test the impact of birth characteristics on the risk of atopic dermatitis. Results. Apgar score, OR (per unit) = 1.23 (1.06–1.44), P = 0.008, and female sex, OR = 1.31 (1.06–1.61), P = 0.012, were risk factors for atopic dermatitis in cotwin control analysis, whereas birth anthropometric factors were not significantly related to disease development. Risk estimates in monozygotic and dizygotic twins were not significantly different for the identified risk factors. Conclusions. In this population-based cotwin control study, high Apgar score was a risk factor for atopic dermatitis. This novel finding must be confirmed in subsequent studies. PMID:24222775
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Hall, Jennifer; Mansfield, Louise; Kay, Tess; McConnell, Alison K
2015-02-15
A lack of physical activity and excessive sitting can contribute to poor physical health and wellbeing. The high percentage of the UK adult population in employment, and the prolonged sitting associated with desk-based office-work, make these workplaces an appropriate setting for interventions to reduce sedentary behaviour and increase physical activity. This pilot study aims to determine the effect of an office-based sit-stand workstation intervention, compared with usual desk use, on daily sitting, standing and physical activity, and to examine the factors that underlie sitting, standing and physical activity, within and outside, the workplace. A randomised control trial (RCT) comparing the effects of a sit-stand workstation only and a multi-component sit-stand workstation intervention, with usual desk-based working practice (no sit-stand workstation) will be conducted with office workers across two organisations, over a 12 month period (N = 30). The multicomponent intervention will comprise organisational, environmental and individual elements. Objective data will be collected at baseline, and after 2-weeks, 3-months, 6-months and 12-months of the intervention. Objective measures of sitting, standing, and physical activity will be made concurrently (ActivPAL3™ and ActiGraph (GT3X+)). Activity diaries, ethnographic participant observation, and interviews with participants and key organisational personnel will be used to elicit understanding of the influence of organisational culture on sitting, standing and physical activity behaviour in the workplace. This study will be the first long-term sit-stand workstation intervention study utilising an RCT design, and incorporating a comprehensive process evaluation. The study will generate an understanding of the factors that encourage and restrict successful implementation of sit-stand workstation interventions, and will help inform future occupational wellbeing policy and practice. Other strengths include the objective measurement of physical activity during both work and non-work hours. Clinicaltrials.gov identifier NCT02172599, 22nd June 2014.
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A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves.
Meng, Xiang Jing; Lu, Li Li; Gu, Guo Feng; Xiao, Min
2010-09-01
An efficient nicotine-degrading fungus was isolated from tobacco leaves and identified as Aspergillus oryzae 112822 based on morphological characteristics and sequence analysis of 18S rDNA, 5.8S rDNA and the internal transcribed spacer (5.8S-ITS region). When the strain was cultured in a medium with tobacco leaf extract for 40 h, the maximum amount of cell growth was 3.6 g l(-1) and nicotine degradation was 2.19 g l(-1). The intermediates of nicotine degradation by resting cells were isolated by preparative TLC or semi-preparative HPLC, and identified by TLC, MS, NMR, Fourier-transform (FT)-IR and GC-MS analysis. The pathway for nicotine degradation in A. oryzae 112822 was proposed to be from nicotine to 2,3-dihydroxypyridine through the intermediates nornicotine, myosmine, N-methylnicotinamide and 2-hydroxy-N-methylnicotinamide. The ring of 2,3-dihydroxypyridine was opened between the 2- and 3-hydroxy positions to yield succinic acid. N-methylnicotinamide and 2,3-dihydroxypyridine were satisfactorily verified as metabolites of nicotine degradation. This is the first elucidation of a pathway for nicotine degradation in fungi. Copyright 2010 Elsevier Masson SAS. All rights reserved.
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Atopic eczema and the filaggrin story.
Brown, Sara J; Irvine, Alan D
2008-06-01
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema represents the single most significant breakthrough in understanding the genetic basis of this complex disorder. The association has been replicated in multiple independent studies during the past 2 years with the use of various methodologies, from populations in Europe, the United States, and Japan. Filaggrin plays a key role in epidermal barrier function, and its association with atopic eczema emphasizes the importance of barrier dysfunction in eczema pathogenesis. This review aims to summarize the current state of knowledge regarding the role of FLG mutations in ichthyosis vulgaris, atopic eczema, and other skin disorders, with an emphasis on potential clinical applications. Further research is needed to clarify the precise role of filaggrin in skin and systemic atopic disease, to pave the way for novel therapeutic interventions.
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Diaper area skin microflora of normal children and children with atopic dermatitis.
Keswick, B H; Seymour, J L; Milligan, M C
1987-01-01
In vitro studies established that neither cloth nor disposable diapers demonstrably contributed to the growth of Escherichia coli, Proteus vulgaris, Staphylococcus aureus, or Candida albicans when urine was present as a growth medium. In a clinical study of 166 children, the microbial skin flora of children with atopic dermatitis was compared with the flora of children with normal skin to determine the influence of diaper type. No biologically significant differences were detected between groups wearing disposable or cloth diapers in terms of frequency of isolation or log mean recovery of selected skin flora. Repeated isolation of S. aureus correlated with atopic dermatitis. The log mean recovery of S. aureus was higher in the atopic groups. The effects of each diaper type on skin microflora were equivalent in the normal and atopic populations. PMID:3546360
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A prospective study on canine atopic dermatitis and food-induced allergic dermatitis in Switzerland.
Picco, F; Zini, E; Nett, C; Naegeli, C; Bigler, B; Rüfenacht, S; Roosje, P; Gutzwiller, M E Ricklin; Wilhelm, S; Pfister, J; Meng, E; Favrot, C
2008-06-01
Canine atopic dermatitis sensu stricto and food-induced allergic dermatitis are common canine skin conditions, which are often considered clinically undistinguishable. Several attempts have been made to describe populations of atopic dogs and determine breed predisposition but the results were often biased by the use of hospital populations as control group. The present study aims to describe a population of Swiss atopic and food-allergic dogs and to compare it with a data set representing more than 85% of all Swiss dogs. The study, which was carried out during 1 year in several practices and teaching hospital in Switzerland, describes a group of 259 allergic dogs, determines breed predisposition for atopic dermatitis and food-induced allergic dermatitis, compares the clinical signs and features of both conditions, and outlines the clinical picture of five frequently affected breeds.
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Saito, Kyoko; Yokoyama, Tetsuji; Miyake, Yoshihiro; Sasaki, Satoshi; Tanaka, Keiko; Ohya, Yukihiro; Hirota, Yoshio
2010-02-01
Interest has increased in the possibility that maternal dietary intake during pregnancy might influence the development of allergic disorders in children. The present prospective study examined the association of maternal intake of selected foods high in fatty acids and specific types of fatty acids during pregnancy with the risk of suspected atopic eczema among Japanese infants aged 3-4 months. Subjects were 771 mother-child pairs. Information on maternal dietary intake during pregnancy was assessed with a validated self-administered diet history questionnaire. The term 'suspected atopic eczema' was used to define an outcome based on results of our questionnaire completed by mothers 3-4 months postpartum. The risk of suspected atopic eczema was 8.4% (n = 65). Higher maternal intake of meat during pregnancy was significantly associated with an increased risk of suspected atopic eczema in the offspring: the multivariate odds ratio (OR) for the highest vs. lowest quartile was 2.59 [95% confidence interval (CI): 1.15-6.17, p for trend = 0.01]. The positive association was strengthened when the definition of the outcome was confined to a definite physician's diagnosis of atopic eczema (n = 35): the multivariate OR between extreme quartiles was 3.53 (95% CI: 1.19-12.23, p for trend = 0.02). No material exposure-response relationships were observed between maternal intake of eggs, dairy products, fish, total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, linoleic acid, arachidonic acid and cholesterol and the ratio of n-3 to n-6 polyunsaturated fatty acid consumption and the risk of suspected atopic eczema. Higher maternal meat intake may increase the risk of infantile atopic eczema, whereas we found no evidence that maternal intake of fish and n-3 polyunsaturated fatty acids are preventive against infantile atopic eczema. (c) 2009 John Wiley & Sons A/S
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Kosheleva, I V; Bitkina, O A; Klivitskaya, N A; Shadyzheva, L I
This article was designed to discuss the therapeutic potential of various non-pharmacological and physiotherapeutic methods for the treatment and rehabilitation of the patients presenting with atopic dermatitis (AD) during the inter-recurrence period of the disease. The particular emphasis is placed on the physical agents most frequently used for the purpose with special reference to the combined therapy of atopic dermatitis in the adults and children and to their rehabilitation in the inter-exacerbation periods. In addition, the data on the prospects for the use of various medications intended for tissue- and organotherapy of the patients suffering from atopic dermatitis are presented. The main traditional approaches to the management of the patients with atopic dermatitis under conditions of the spa and health resort facilities are considered based on the original experience of the authors including the application of various modes of ozone therapy regarded as a physiotherapeutic procedure for the treatment of atopic dermatitis in the children and adult patients, their rehabilitation, and the prevention of exacerbations of the pathological process based on the external and/or systemic application of the ozone-oxygen gaseous mixture. The selected modalities of ozone therapy used to treat various clinical forms and stages of the atopic dermatitis differing in severity are described in detail. The data on the influence of ozone therapy on a variety of pathogenetic factors of atopic dermatitis are presented as obtained by the investigations into dynamics of the characteristics of immunity, microcirculation, and the levels of free radical metabolites. The results of the study give evidence of the high effectiveness of ozone therapy as a method of physiotherapeutic treatment both in the capacity of a component of combined therapy during the acute phase of atopic dermatitis and as the means of secondary (post-exposure) prophylaxis of the exacerbations and relapses of this condition based at the medical and preventive treatment facilities of various specialization.
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Hadgraft, Nyssa T; Brakenridge, Charlotte L; LaMontagne, Anthony D; Fjeldsoe, Brianna S; Lynch, Brigid M; Dunstan, David W; Owen, Neville; Healy, Genevieve N; Lawler, Sheleigh P
2016-09-05
Office workers spend a large proportion of their working hours sitting. This may contribute to an increased risk of chronic disease and premature mortality. While there is growing interest in workplace interventions targeting prolonged sitting, few qualitative studies have explored workers' perceptions of reducing occupational sitting outside of an intervention context. This study explored barriers to reducing office workplace sitting, and the feasibility and acceptability of strategies targeting prolonged sitting in this context. Semi-structured interviews were conducted with a convenience sample of 20 office workers (50 % women), including employees and managers, in Melbourne, Australia. The three organisations (two large, and one small organisation) were from retail, health and IT industries and had not implemented any formalised approaches to sitting reduction. Questions covered barriers to reducing sitting, the feasibility of potential strategies aimed at reducing sitting, and perceived effects on productivity. Interviews were audiotaped and transcribed verbatim. Data were analysed using thematic analysis. Participants reported spending most (median: 7.2 h) of their working hours sitting. The nature of computer-based work and exposure to furniture designed for a seated posture were considered to be the main factors influencing sitting time. Low cost strategies, such as standing meetings and in-person communication, were identified as feasible ways to reduce sitting time and were also perceived to have potential productivity benefits. However, social norms around appropriate workplace behaviour and workload pressures were perceived to be barriers to uptake of these strategies. The cost implications of height-adjustable workstations influenced perceptions of feasibility. Managers noted the need for an evidence-based business case supporting action on prolonged sitting, particularly in the context of limited resources and competing workplace health priorities. While a number of low-cost approaches to reduce workplace sitting are perceived to be feasible and acceptable in the office workplace, factors such as work demands and the organisational social context may still act as barriers to greater uptake. Building a supportive organisational culture and raising awareness of the adverse health effects of prolonged sitting may be important for improving individual-level and organisational-level motivation for change.
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Thompson, Christopher; Wylie, Lee J.; Blackwell, Jamie R.; Fulford, Jonathan; Black, Matthew I.; Kelly, James; McDonagh, Sinead T. J.; Carter, James; Bailey, Stephen J.; Vanhatalo, Anni
2017-01-01
We hypothesized that 4 wk of dietary nitrate supplementation would enhance exercise performance and muscle metabolic adaptations to sprint interval training (SIT). Thirty-six recreationally active subjects, matched on key variables at baseline, completed a series of exercise tests before and following a 4-wk period in which they were allocated to one of the following groups: 1) SIT and NO3−-depleted beetroot juice as a placebo (SIT+PL); 2) SIT and NO3−-rich beetroot juice (~13 mmol NO3−/day; SIT+BR); or 3) no training and NO3−-rich beetroot juice (NT+BR). During moderate-intensity exercise, pulmonary oxygen uptake was reduced by 4% following 4 wk of SIT+BR and NT+BR (P < 0.05) but not SIT+PL. The peak work rate attained during incremental exercise increased more in SIT+BR than in SIT+PL (P < 0.05) or NT+BR (P < 0.001). The reduction in muscle and blood [lactate] and the increase in muscle pH from preintervention to postintervention were greater at 3 min of severe-intensity exercise in SIT+BR compared with SIT+PL and NT+BR (P < 0.05). However, the change in severe-intensity exercise performance was not different between SIT+BR and SIT+PL (P > 0.05). The relative proportion of type IIx muscle fibers in the vastus lateralis muscle was reduced in SIT+BR only (P < 0.05). These findings suggest that BR supplementation may enhance some aspects of the physiological adaptations to SIT. NEW & NOTEWORTHY We investigated the influence of nitrate-rich and nitrate-depleted beetroot juice on the muscle metabolic and physiological adaptations to 4 wk of sprint interval training. Compared with placebo, dietary nitrate supplementation reduced the O2 cost of submaximal exercise, resulted in greater improvement in incremental (but not severe-intensity) exercise performance, and augmented some muscle metabolic adaptations to training. Nitrate supplementation may facilitate some of the physiological responses to sprint interval training. PMID:27909231
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Makhsous, Mohsen; Lin, Fang; Bankard, James; Hendrix, Ronald W; Hepler, Matthew; Press, Joel
2009-01-01
Background Compared to standing posture, sitting decreases lumbar lordosis, increases low back muscle activity, disc pressure, and pressure on the ischium, which are associated with occupational LBP. A sitting device that reduces spinal load and low back muscle activities may help increase sitting comfort and reduce LBP risk. The objective of this study is to investigate the biomechanical effect of sitting with a reduced ischial support and an enhanced lumbar support (Off-Loading) on load, interface pressure and muscle activities. Methods A laboratory test in low back pain (LBP) and asymptomatic subjects was designed to test the biomechanical effect of using the Off-Loading sitting posture. The load and interface pressure on seat and the backrest, and back muscle activities associated with usual and this Off-Loading posture were recorded and compared between the two postures. Results Compared with Normal (sitting upright with full support of the seat and flat backrest) posture, sitting in Off-Loading posture significantly shifted the center of the force and the peak pressure on the seat anteriorly towards the thighs. It also significantly decreased the contact area on the seat and increased that on the backrest. It decreased the lumbar muscle activities significantly. These effects are similar in individuals with and without LBP. Conclusion Sitting with reduced ischial support and enhanced lumbar support resulted in reduced sitting load on the lumbar spine and reduced the lumbar muscular activity, which may potentially reduce sitting-related LBP. PMID:19193245
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Defining intrinsic vs. extrinsic atopic dermatitis.
Karimkhani, Chante; Silverberg, Jonathan I; Dellavalle, Robert P
2015-06-16
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition characterized by eczematous lesions, i.e. ill-demarcated erythematous patches and plaques. AD is commonly associated with elevated immunoglobulin E (IgE) and atopic disorders, such as asthma, hay fever, and food allergies. Rackemann and Mallory were some of the first to distinguish between asthma based on the presence ("extrinsic") or absence ("intrinsic") of allergy. This distinction has subsequently been applied to AD based on the presence ("extrinsic") or absence ("intrinsic") of increased IgE and atopic disease. Although the distinction between intrinsic and extrinsic AD is widely used, it remains controversial.
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[Atopic dermatitis and domestic animals].
Song, M
2000-09-01
Several arguments are raised attributing to aeroallergens an important role in atopic dermatitis. The aeroallergens that penetrate the epidermis could be fixed by IgE on the Langerhans cells and then induce a cellular mediator reaction comparable to that of allergic contact eczema. Patch tests have been developed to evaluate the role of aeroallergens (dust mites, animal dander, etc.). Preventive anti-dust mites measures in the home of atopic patients are recommended. Eviction of domestic animals (cat, dog, etc.) or avoidance measures for animal dander in the home can produce improvement in atopic dermatitis. Oral specific immunotherapy is being validated as a treatment for this disease.
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Mitchell, Amy E; Fraser, Jennifer A; Morawska, Alina; Ramsbotham, Joanne; Yates, Patsy
2016-12-01
The development of child behaviour and parenting difficulties is understood to undermine treatment outcomes for children with atopic dermatitis. Past research has reported on correlates of child behaviour difficulties. However, few research studies have sought to examine parenting confidence and practices in this clinical group. To examine relationships between child, parent, and family variables, parent-reported and directly-observed child and parent behaviour, parents' self-efficacy with managing difficult child behaviour, self-reported parenting strategies, and disease severity. Cross-sectional study design. Parent-child dyads (N=64) were recruited from the dermatology clinic of a paediatric tertiary referral hospital in Brisbane, Australia. Children had a diagnosis of atopic dermatitis of ≥3months and no other chronic health conditions except asthma, allergic rhinitis, or allergy. Parents completed self-report measures assessing child behaviour; parent depression, anxiety, and stress; parenting conflict and relationship satisfaction; self-efficacy with managing difficult child behaviour, and use of ineffective parenting strategies; and self-efficacy for managing atopic dermatitis, and performance of atopic dermatitis management tasks. The Scoring Atopic Dermatitis index was used to assess disease severity. Routine at-home treatment sessions were coded for parent and child behaviour. Pearson's and Spearman's correlations identified relationships (p<0.05) between self-efficacy with managing difficult child behaviour and child behaviour problems, parent depression and stress, parenting conflict and relationship satisfaction, and household income. There were also relationships between each of these variables and use of ineffective parenting strategies. Greater use of ineffective parenting strategies was associated with more severe atopic dermatitis. Using multiple linear regressions, child behaviour and household income explained unique variance in self-efficacy for managing difficult child behaviour; household income alone explained unique variance in use of ineffective parenting strategies. Self-efficacy for managing difficult child behaviour and self-efficacy for managing atopic dermatitis were positively correlated (rho=0.48, p<0.001), and more successful self-reported performance of atopic dermatitis management tasks correlated with less permissive (r=0.35, p=0.005) and less authoritarian (r=0.41, p=0.001) parenting. Directly observed aversive child behaviour was associated with more severe atopic dermatitis, parent stress, and parent-reported child behaviour problems. This study revealed relationships between parents' self-efficacy and parenting practices across the domains of child behaviour management and atopic dermatitis management. Parents of children with more severe atopic dermatitis may have difficulty responding to child behaviour difficulties appropriately, potentially impacting on illness management. Incorporating parent and parenting support within treatment plans may improve not only child and family wellbeing, but also treatment outcomes. Copyright © 2016 Elsevier Ltd. All rights reserved.
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H Λ 3 and H - Λ ¯ 3 production in Pb–Pb collisions at s NN = 2.76 TeV
DOE Office of Scientific and Technical Information (OSTI.GOV)
Adam, J.; Adamová, D.; Aggarwal, M. M.
We measured the production of the hypertriton nucleimore » $$3\\atop{Λ}$$ and $$3\\atop{\\bar{Λ}}$$$\\bar{H}$$ for the first time in Pb-Pb collisions at √s NN = 2.76 TeVwith the ALICE experiment at LHC. The p T-integrated $$3\\atop{Λ}$$ yield in one unity of rapidity, dN/dy x B.R.(($$3\\atop{Λ}$$ -> 3He,π -)) = (3.86 ± 0.77(stat.) ± 0.68(syst.)) x 10 -5 in the 0-10% most central collisions, is consistent with the predictions from a statistical thermal model using the same temperature as for the light hadrons. Furthermore, the coalescence parameter B 3 shows a dependence on the transverse momentum, similar to the B 2 of deuterons and the B 3 of He 3 nuclei. The ratio of yields S 3 = $$3\\atop{Λ}$$/(He 3 x Lambda/p) was measured to be S 3 = 0.60 ± 0.13(stat.) ± 0.21(syst.) in 0-10% centrality events; this value is compared to different theoretical models. The measured S 3 is compatible with thermal model predictions. The $$3\\atop{Λ}$$ lifetime, τ = 181$$+54\\atop{-39}$$(stat.) ± 33(syst.) ps, that we measured, is in agreement within 1σ with the world average value.« less
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H Λ 3 and H - Λ ¯ 3 production in Pb–Pb collisions at s NN = 2.76 TeV
Adam, J.; Adamová, D.; Aggarwal, M. M.; ...
2016-01-25
We measured the production of the hypertriton nucleimore » $$3\\atop{Λ}$$ and $$3\\atop{\\bar{Λ}}$$$\\bar{H}$$ for the first time in Pb-Pb collisions at √s NN = 2.76 TeVwith the ALICE experiment at LHC. The p T-integrated $$3\\atop{Λ}$$ yield in one unity of rapidity, dN/dy x B.R.(($$3\\atop{Λ}$$ -> 3He,π -)) = (3.86 ± 0.77(stat.) ± 0.68(syst.)) x 10 -5 in the 0-10% most central collisions, is consistent with the predictions from a statistical thermal model using the same temperature as for the light hadrons. Furthermore, the coalescence parameter B 3 shows a dependence on the transverse momentum, similar to the B 2 of deuterons and the B 3 of He 3 nuclei. The ratio of yields S 3 = $$3\\atop{Λ}$$/(He 3 x Lambda/p) was measured to be S 3 = 0.60 ± 0.13(stat.) ± 0.21(syst.) in 0-10% centrality events; this value is compared to different theoretical models. The measured S 3 is compatible with thermal model predictions. The $$3\\atop{Λ}$$ lifetime, τ = 181$$+54\\atop{-39}$$(stat.) ± 33(syst.) ps, that we measured, is in agreement within 1σ with the world average value.« less
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Leibovici, Vera; Ramot, Yuval; Siam, Rula; Siam, Ihab; Hadayer, Noa; Strauss-Liviatan, Nurith; Hochberg, Malka
2014-12-01
There are discrepancies in the literature regarding the prevalence of tinea pedis in psoriasis. The aim of this investigation was to conduct a cross-sectional study of the prevalence of tinea pedis in psoriasis compared to atopic dermatitis patients and normal controls. We enrolled 232 psoriatic patients, 190 atopic dermatitis patients and 202 normal controls, between the years 2010 and 2013. The prevalence of tinea pedis was 13.8% in psoriasis patients, not significantly different from that in atopic dermatitis patients 8.4% (P = 0.092)), but significantly higher than in normal controls 7.4% (P = 0.043). Both gender and age affected the prevalence of tinea pedis in psoriasis and normal controls, while only age affected the prevalence of tinea pedis in atopic dermatitis. Regarding gender, there was higher prevalence of tinea pedis in men: 19.1% (P = 0.019) in psoriasis and 12.1% (P = 0.013) in normal controls. Age affected the prevalence of tinea pedis in normal controls (P < 0.001), psoriasis patients (P = 0.001) and atopic dermatitis patients (P = 0.001), with higher prevalence with increasing age. Trichophyton rubrum was the most common species in psoriasis (71.9%), atopic dermatitis (75.0%) and normal controls (73.3%). Our study found a relatively high prevalence of tinea pedis among psoriasis patients. © 2014 Blackwell Verlag GmbH.
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Lee, Hae-Jin; Lee, Noo Ri; Jung, Minyoung; Kim, Dong Hye; Choi, Eung Ho
2015-12-01
Prolonged and/or repeated damage to the skin barrier followed by atopic dermatitis (AD) is an initial step in atopic march that ultimately progresses to respiratory allergy. Maintaining normal stratum corneum (SC) acidity has been suggested as a therapeutic or preventive strategy for barrier impairment caused by skin inflammation. We determined whether a representative AD murine model, NC/Nga mice, develops airway inflammation after repeated epicutaneous application followed by inhalation of house dust mite (HDM), implying atopic march, and whether prolongation of non-proper SC acidity accelerates respiratory allergy. HDM was applied to the skin of NC/Nga mice, accompanied by the application of neutral cream (pH 7.4) or acidic cream (pH 2.8) for 6 weeks. Intranasal inhalation of HDM was administered daily during the last 3 days. Repeated epicutaneous applications followed by inhalation of HDM in NC/Nga mice induced an atopic march-like progression from AD lesions to respiratory allergy. Concurrent neutral cream treatment accelerated or aggravated the allergic inflammation in the skin and respiratory system, whereas an acidic cream partially alleviated these symptoms. Collectively, we developed an atopic march in NC/Nga mice by HDM application, and found that prevention of a neutral environment in the SC may be an interventional method to inhibit the march.
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Skin prick testing in atopic eczema: atopic to what and at what age?
Hon, Kam Lun; Wang, Shuxin Susan; Wong, Wing Lam; Poon, Wing Kwan; Mak, Ka Yi; Leung, Ting Fan
2012-05-01
Atopic eczema is a common and distressing disease. This study aimed to review the age-dependent pattern of atopic sensitization to food and aeroallergens in patients with eczema by skin prick testing. The results of skin prick test (SPT), serum IgE, bronchial challenge test, and family history of atopy in eczema patients seen at a pediatric dermatology clinic were reviewed. SPT results were available in 816 eczema patients. In these patients, 90% had atopic sensitization to at least one aeroallergen, 69% to at least one food allergen, and 94% to at least one allergen by SPT. Together with a family history of atopy in parents or siblings and a personal history of airway atopies, 97% and 99.8% of the patients were atopic, respectively. Bronchial hyper-reactivity (BHR) was demonstrated in 44% of 339 patients. Aeroallergen was more prevalent than food allergen sensitization among children older than 10 years. The mites (D. pteronysissnus, D. farinae and Blomia Tropicalis) were the most prevalent allergens regardless of age and BHR, but D. pteronysissnus and D. farinae sensitization were more prevalent among BHR-positive patients. Beef is the least sensitized food protein in all ages. The majority of patients with eczema are atopic to aeroallergens. The mites (D. pteronysissnus, D. farinae and Blomia Tropicalis) are the most prevalent allergens regardless of age and BHR.