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Sample records for ionov i anion-radikalami

  1. Juno I -- Explorer I

    NASA Technical Reports Server (NTRS)

    1958-01-01

    Juno I, a slightly modified Jupiter-C launch vehicle, shortly before the January 31, 1958 launch of America's first satellite, Explorer I. The Jupiter-C, developed by Dr. Wernher von Braun and the rocket team at Redstone Arsenal in Huntsville, Alabama, consisted of a modified version of the Redstone rocket's first stage and two upper stages of clustered Baby Sergeant rockets developed by the Jet Propulsion Laboratory.

  2. SAGE I

    Atmospheric Science Data Center

    2014-05-12

    SAGE I Data and Information Stratospheric Aerosol and Gas Experiment ( SAGE ) I gathered data concerning the spatial distribution of stratospheric aerosols, ozone and nitrogen dioxide on a global scale. SAGE I used a Sun Photometer. Guide Documents:  Project ...

  3. 1; '" ~i.im~

    Center for Drug Evaluation (CDER)

    ... t ~ .. I:~ ~, r1 " )íJ .( l\\ ,# f ~ .; , r 1I1§~.OGlP.~.mi .. !II .. 0 . .... t- !!,. i:qrzrr -19~,i;!;¡ $ i'' is il Il '\\ii II ~ w "' =~ &2L;;&Æ__ II .. i: Ci.)ill.ii.iill~~~1I ~ . . .. ...

  4. I3P Overview

    NASA Video Gallery

    Deborah Diaz, the NASA's Deputy Chief Information Officer, talks about the Information Technology Infrastructure Integration Program (I3P). I3P is NASA's initiative to provide Agency-wide managemen...

  5. 75 FR 50038 - Temporary Closure of I-70 (I-70/I-465 West Leg Interchange to the I-70/I-65 South Split...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... Federal Highway Administration Temporary Closure of I-70 (I-70/I-465 West Leg Interchange to the I-70/I-65... Department of Transportation (INDOT) to temporarily close a segment of I-70 (from the I-70/I-465 west leg... temporary closure of a segment of I-70 in Indiana (from the I-70/I-465 west leg interchange to the...

  6. 75 FR 38606 - Temporary Closure of I-70 (I-70/I-465 West Leg Interchange to the I-70/I-65 South Split...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... Federal Highway Administration Temporary Closure of I-70 (I-70/I-465 West Leg Interchange to the I-70/I-65...-70 (from the I-70/I-465 west leg interchange to the I-70/I-65 south split interchange) on October 7... leg interchange to the I-70/I-65 south split interchange) on October 7, 2010, for a 12-hour...

  7. Can I Prevent Acne?

    MedlinePlus

    ... I Help a Friend Who Cuts? Can I Prevent Acne? KidsHealth > For Teens > Can I Prevent Acne? Print A A A Text Size What's ... too. Although there is no surefire way to prevent acne, try these tips to help reduce the ...

  8. Quantized Algebra I Texts

    ERIC Educational Resources Information Center

    DeBuvitz, William

    2014-01-01

    I am a volunteer reader at the Princeton unit of "Learning Ally" (formerly "Recording for the Blind & Dyslexic") and I recently discovered that high school students are introduced to the concept of quantization well before they take chemistry and physics. For the past few months I have been reading onto computer files a…

  9. Crystallization of lysozyme with (<i>R>)-, (<i>S>)- and (<i>RS>)-2-methyl-2,4-pentanediol

    SciTech Connect

    Stauber, Mark; Jakoncic, Jean; Berger, Jacob; Karp, Jerome M.; Axelbaum, Ariel; Sastow, Dahniel; Buldyrev, Sergey V.; Hrnjez, Bruce J.; Asherie, Neer

    2015-03-01

    Chiral control of crystallization has ample precedent in the small-molecule world, but relatively little is known about the role of chirality in protein crystallization. In this study, lysozyme was crystallized in the presence of the chiral additive 2-methyl-2,4-pentanediol (MPD) separately using the <i>R> and <i>S> enantiomers as well as with a racemic <i>RS> mixture. Crystals grown with (<i>R>)-MPD had the most order and produced the highest resolution protein structures. This result is consistent with the observation that in the crystals grown with (<i>R>)-MPD and (<i>RS>)-MPD the crystal contacts are made by (<i>R>)-MPD, demonstrating that there is preferential interaction between lysozyme and this enantiomer. These findings suggest that chiral interactions are important in protein crystallization.

  10. Thallium (I), soluble salts

    Integrated Risk Information System (IRIS)

    Thallium ( I ) , soluble salts ; CASRN Various Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarc

  11. Ovarian Cancer Stage I

    MedlinePlus

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage I Add to My Pictures View /Download : ... 1650x675 View Download Large: 3300x1350 View Download Title: Ovarian Cancer Stage I Description: Three-panel drawing of stage ...

  12. Comparative genomics of <i>Fructobacillus> spp. and <i>Leuconostoc> spp. reveals niche-specific evolution of <i>Fructobacillus> spp.

    SciTech Connect

    Endo, Akihito; Tanizawa, Yasuhiro; Tanaka, Naoto; Maeno, Shintaro; Kumar, Himanshu; Shiwa, Yuh; Okada, Sanae; Yoshikawa, Hirofumi; Dicks, Leon; Nakagawa, Junichi; Arita, Masanori

    2015-12-29

    In this study, <i>Fructobacillus> spp. in fructose-rich niches belong to the family <i>Leuconostocaceae>. They were originally classified as <i>Leuconostoc> spp., but were later grouped into a novel genus, <i>Fructobacillus> , based on their phylogenetic position, morphology and specific biochemical characteristics. The unique characters, so called fructophilic characteristics, had not been reported in the group of lactic acid bacteria, suggesting unique evolution at the genome level. Here we studied four draft genome sequences of <i>Fructobacillus> spp. and compared their metabolic properties against those of <i>Leuconostoc> spp. As a result, <i>Fructobacillus> species possess significantly less protein coding sequences in their small genomes. The number of genes was significantly smaller in carbohydrate transport and metabolism. Several other metabolic pathways, including TCA cycle, ubiquinone and other terpenoid-quinone biosynthesis and phosphotransferase systems, were characterized as discriminative pathways between the two genera. The adhE gene for bifunctional acetaldehyde/alcohol dehydrogenase, and genes for subunits of the pyruvate dehydrogenase complex were absent in <i>Fructobacillus> spp. The two genera also show different levels of GC contents, which are mainly due to the different GC contents at the third codon position. In conclusion, the present genome characteristics in <i>Fructobacillus> spp. suggest reductive evolution that took place to adapt to specific niches.

  13. I'm Pregnant. Should I Get a Flu Shot?

    MedlinePlus

    ... Cuts? I'm Pregnant. Should I Get a Flu Shot? KidsHealth > For Teens > I'm Pregnant. Should I Get a Flu Shot? Print A A A Text Size I ... weeks pregnant. Do I need to get the flu vaccine or will it affect my pregnancy? – Eliza* ...

  14. I Have Braces: How Can I Eat Fruits and Veggies?

    MedlinePlus

    ... Cuts? I Have Braces. How Can I Eat Fruits and Veggies? KidsHealth > For Teens > I Have Braces. How Can I Eat Fruits and Veggies? Print A A A Text Size ... weight. I read about eating 5 servings of fruits and veggies a day. But I can't ...

  15. Radiological assistance program: Region I. Part I

    SciTech Connect

    Musolino, S.V.; Kuehner, A.V.; Hull, A.P.

    1985-07-15

    The purpose of the Radiological Assistance Program (RAP) is to make DOE resources available and provide emergency assistance to state and local agencies in order to control radiological hazards, protect the public health and safety, and minimize the loss of property. This plan is an integral part of a nationwide program of radiological assistance established by the US DOE, and is implemented on a regional basis. The Brookhaven Area Office (BHO) Radiological Assistance Program is applicable to DOE Region I, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia. The BHO RAP-1 has been developed to: (a) ensure the availability of an effective radiological assistance capability to ensure the protection of persons and property; (b) provide guidelines to RAP-1 Team personnel for the evaluation of radiological incidents and implementation of corrective actions; (c) maintain liaison with other DOE installations, Federal, State and local organizations which may become involved in radiological assistance operations in Region I; and (d) encourage development of a local capability to cope with radiological incidents.

  16. How Can I Manage Stress?

    MedlinePlus

    ... Can I Quit Smoking? How Can I Manage Stress? How Can I Make My Lifestyle Healthier? How Can I Monitor My Cholesterol, Blood Pressure and Weight? Popular Articles 1 Understanding Blood Pressure ...

  17. I Remember Highlander

    ERIC Educational Resources Information Center

    Williams-Hawkins, Maria

    2016-01-01

    "I Remember Highlander" reflects on the life choices of Marion Barry and Herman Henning Jr., fraternity brothers who sought the same goal but took different paths. The essay examines cultural and family situations that shaped lives and decisions.

  18. Collider Signal I :. Resonance

    NASA Astrophysics Data System (ADS)

    Tait, Tim M. P.

    2010-08-01

    These TASI lectures were part of the summer school in 2008 and cover the collider signal associated with resonances in models of physics beyond the Standard Model. I begin with a review of the Z boson, one of the best-studied resonances in particle physics, and review how the Breit-Wigner form of the propagator emerges in perturbation theory and discuss the narrow width approximation. I review how the LEP and SLAC experiments could use the kinematics of Z events to learn about fermion couplings to the Z. I then make a brief survey of models of physics beyond the Standard Model which predict resonances, and discuss some of the LHC observables which we can use to discover and identify the nature of the BSM physics. I finish up with a discussion of the linear moose that one can use for an effective theory description of a massive color octet vector particle.

  19. iCARE

    Cancer.gov

    The iCARE R Package allows researchers to quickly build models for absolute risk, and apply them to estimate an individual's risk of developing disease during a specifed time interval, based on a set of user defined input parameters.

  20. Apps I Have Loved

    ERIC Educational Resources Information Center

    Schaffhauser, Dian

    2011-01-01

    According to a March estimate from Distimo, there were 653,614 apps in the iPhone, Android, iPad, BlackBerry, and Windows Mobile stores alone. So, is it any wonder that these busy people have found a few that come in handy on the job? Mobile apps are as indispensable to district IT executives as they are becoming in the classroom--for professional…

  1. Why I Love Vendors

    SciTech Connect

    Wiley, H. S.

    2010-02-01

    In December, I attended the annual meeting of the American Society for Cell Biology, as I have done regularly for the last several decades. It is always a good way to catch up with old friends and look for the latest trends in cell biology. I rarely attend the talks, having found that they more reflect the fashion of the moment (or the past) than the direction of the field. Poster sessions are more to my liking, since they provide a chance to talk to enthusiastic young scientists in the trenches. But my favorite stop has always been the vendor booths. When I tell my friends that I love visiting vendor booths, most of them seem to think I am kidding. At meetings, many scientists seem to feel that vendors are necessary evils. They provide free candy and cheap pens in exchange for bombarding us with ads and scanning our badges. Like popup ads in web browsers, we have learned to both ignore and accept them as part of the landscape. It is unfortunate that we have become so inured to their presence. Talks and posters capture exciting research from the last few years or months, but vendor booths capture the future, offering one of the clearest visions of where a field is going.

  2. Structure of photosystem I.

    PubMed

    Fromme, P; Jordan, P; Krauss, N

    2001-10-30

    In plants and cyanobacteria, the primary step in oxygenic photosynthesis, the light induced charge separation, is driven by two large membrane intrinsic protein complexes, the photosystems I and II. Photosystem I catalyses the light driven electron transfer from plastocyanin/cytochrome c(6) on the lumenal side of the membrane to ferredoxin/flavodoxin at the stromal side by a chain of electron carriers. Photosystem I of Synechococcus elongatus consists of 12 protein subunits, 96 chlorophyll a molecules, 22 carotenoids, three [4Fe4S] clusters and two phylloquinones. Furthermore, it has been discovered that four lipids are intrinsic components of photosystem I. Photosystem I exists as a trimer in the native membrane with a molecular mass of 1068 kDa for the whole complex. The X-ray structure of photosystem I at a resolution of 2.5 A shows the location of the individual subunits and cofactors and provides new information on the protein-cofactor interactions. [P. Jordan, P. Fromme, H.T. Witt, O. Klukas, W. Saenger, N. Krauss, Nature 411 (2001) 909-917]. In this review, biochemical data and results of biophysical investigations are discussed with respect to the X-ray crystallographic structure in order to give an overview of the structure and function of this large membrane protein.

  3. Ares I Avionics Introduction

    NASA Technical Reports Server (NTRS)

    Marchant, Christopher C.

    2009-01-01

    The Ares I is the next generation human-rated launcher for the United States Constellation program. This system is required to provide single fault tolerance within defined crew safety and mission reliability limits. As part of the effort to achieve those safety goals, Ares I includes an avionics subsystem built as a multistring, voting architecture. The avionics design draws upon experience gained from building fly-by-wire systems for Shuttle, X- 38, and Seawolf. Architectural drivers for the avionics design include using proven technologies with existing suppliers of space rated parts for critical functions (to reduce overall development risk), easing the software development effort by using an off-theshelf, DO-178B certifiable, ARINC-653 operating system in the main flight computers, minimizing mutual data and power connections that might lead to a common-mode hardware failure of the redundant avionics strings, and centralizing overall Ares I command & control within the Upper Stage.

  4. Mucopolysaccharidosis type I.

    PubMed

    Wraith, J E; Jones, Simon

    2014-09-01

    Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of the lysosomal hydrolase a-L-Iduronidase leading to accumulation of the GAGs, dermatan sulfate, and heparan sulphate, The disease spectrum includes a disorder with severe involvement and CNS disease Hurler disease (HPS I H) a chronic disease without CNS disease Scheie disease (HPS I S5) and the intermediate Hurler/Scheie disease(HPS I HIS).The urine GAGs pattern. confirmed by Iduronidase enzyme assay is diagnostic. Over 200 mutations exist. Genotype / phenotype correlation is poor but two nonsense mutations results in Hurler disease.The skeletal disease dysostosis multiplex (DM) is seen in severe variants of MPS I. The hypoplastic odontoid putting these patients at high risk of cervical cord damage. MPS IH (Hurler Disease) affected infants develop a spinal 'gibbus' deformity, persistent nasal discharge, middle ear effusions and frequent upper respiratory infection. They have "coarse", facial features, and an enlarged tongue. . Progressive upper airway disease leads to obstructive sleep apnoea. Corneal clouding and cognitive impairment appears, growth ceases. Joint stiffness and contractures limit mobility. Cardiac disease is universal. Death occurs before 10 years. SCHEIE patients are diagnosed as teenagers with hepatomegaly, joint contractures, cardiac valve abnormalities and corneal clouding . Prolonged survival with considerable disability without cognitive impairment is usual. MPS IH/S Hurler/Scheie. is diagnosed by 6.5 years, with variable skeletal and visceral manifestations without cognitive involvement. Joint stiffness, corneal clouding, , umbilical hernia, abnormal facies, hepatomegaly, joint contractures, and cervical myelopathy occur. Patients die in their 20s .Haematopoietic stem cell transplantation (HSCT) the standard treatment of MPS IH for 30 years is unpredictable .When performed before 2 years it can stabilize cognitive impairment. Hepatosplenomegaly, urine GAGs excretion, upper

  5. 129I and 127I transport in the Mississippi River.

    PubMed

    Oktay, S D; Santschi, P H; Moran, J E; Sharma, P

    2001-11-15

    The watershed processes which control 129I/127I ratios, 129I and 127I concentrations, and speciation of iodine isotopes were studied through an investigation into the variability of these parameters in the Mississippi River near New Orleans, undertaken in 1996-1998. Analyses of suspended particulate matter (SPM) revealed a greater percent association of 127I than of 129I, resulting in lower 129I/127I ratios in SPM than in surrounding water. Furthermore, crossflow ultrafiltration showed that organo-iodine was the dominant form for both isotopes, with 70-85% of these isotopes found in the 0.45 microm filter-passing fraction associated with colloidal macromolecular organic matter. 129I showed a weak correlation, 127I no correlation, and 129I/127I ratios a strong inverse correlation with river flow rate. Inverse correlations between 129I/127I ratios and river flow rates can be best explained by rainwater and evapotranspiration dominated ratios at base flow and a lowering of the isotope ratios during higher flow due to extra inputs of 127I from soil weathering. We postulate that different equilibration times for 127I and 129I as well as for bomb-produced 129I and reprocessing-produced 129I are responsible for these fractionation effects and the differential mobilities of these isotopes in the Mississippi River watershed.

  6. 129I and 127I transport in the Mississippi River.

    PubMed

    Oktay, S D; Santschi, P H; Moran, J E; Sharma, P

    2001-11-15

    The watershed processes which control 129I/127I ratios, 129I and 127I concentrations, and speciation of iodine isotopes were studied through an investigation into the variability of these parameters in the Mississippi River near New Orleans, undertaken in 1996-1998. Analyses of suspended particulate matter (SPM) revealed a greater percent association of 127I than of 129I, resulting in lower 129I/127I ratios in SPM than in surrounding water. Furthermore, crossflow ultrafiltration showed that organo-iodine was the dominant form for both isotopes, with 70-85% of these isotopes found in the 0.45 microm filter-passing fraction associated with colloidal macromolecular organic matter. 129I showed a weak correlation, 127I no correlation, and 129I/127I ratios a strong inverse correlation with river flow rate. Inverse correlations between 129I/127I ratios and river flow rates can be best explained by rainwater and evapotranspiration dominated ratios at base flow and a lowering of the isotope ratios during higher flow due to extra inputs of 127I from soil weathering. We postulate that different equilibration times for 127I and 129I as well as for bomb-produced 129I and reprocessing-produced 129I are responsible for these fractionation effects and the differential mobilities of these isotopes in the Mississippi River watershed. PMID:11757603

  7. "I Spy" Engaged Learners.

    ERIC Educational Resources Information Center

    Sassano, Lisa

    2003-01-01

    Encourages student awareness of the connections between their classroom experiences and real life. Develops an idea to motivate and keep track of students' findings, the "I Spy Vocab Words" contest. Describes how the author implemented the contest. Notes how the program has students keep a log of vocabulary words they find in their everyday lives.…

  8. Alexander I. Ignatowski

    PubMed Central

    Konstantinov, Igor E.; Jankovic, Gradimir M.

    2013-01-01

    In 1908, Alexander I. Ignatowski (1875–1955) published his pioneering work that first revealed a relationship between cholesterol-rich food and experimental atherosclerosis. This early experimental work paved a way to the metabolic study of the mechanism of atherosclerosis. Herein, we present a brief account of Ignatowski's work and life. PMID:23914012

  9. SSIP Phase I Roadmap

    ERIC Educational Resources Information Center

    Vinh, Megan; Lucas, Anne; Taylor, Cornelia; Kelley, Grace; Kasprzak, Christina

    2014-01-01

    This roadmap provides a description of the activities involved in the development of the State Systemic Improvement Plan (SSIP) (SPP/APR Indicators C11 and B17) due to the Office of Special Education Programs (OSEP) on April 1, 2015. The roadmap is intended to support states with completing Phase I of the SSIP process. This document provides…

  10. iBank

    ERIC Educational Resources Information Center

    Bermundo, Cesar B.; Bermundo, Alex B.; Ballester, Rex C.

    2012-01-01

    iBank is a project that utilizes a software to create an item Bank that store quality questions, generate test and print exam. The items are from analyze teacher-constructed test questions that provides the basis for discussing test results, by determining why a test item is or not discriminating between the better and poorer students, and by…

  11. Library Studies I Workbook.

    ERIC Educational Resources Information Center

    Frost, William J.

    Developed for use in the Library Studies I component of the Library Studies Program at Bloomsburg University (Pennsylvania), this self-paced workbook is intended to acquaint students with the Harvey A. Andruss Library and help them develop information-seeking skills. The workbook is designed to be used in conjunction with an exercise book, and…

  12. Methods & Strategies: I Wonder...

    ERIC Educational Resources Information Center

    Stevenson, Anne

    2013-01-01

    "I Wonder" boards are a teaching strategy that can be used in the classroom, as well as during science learning opportunities in nonformal settings, such as after-school science programs or summer camps.This simple strategy has led to deeper science exploration in 4-H, as young people learn alongside program staff, teachers, or…

  13. Meatcutting Testbook, Part I.

    ERIC Educational Resources Information Center

    Strazicich, Mirko, Ed.

    This document contains objective tests for each lesson in the Meatcutting Workbook, Part I (see note), which is designed for apprenticeship programs in meatcutting in California. Each of the 36 tests contains from 10 to 45 multiple-choice items. The tests are grouped according to the eight units of the workbook: the apprentice meatcutter; applied…

  14. {sup 129}I Interlaboratory comparison: phase I and phase II

    SciTech Connect

    Caffee, M W; Roberts, M L

    1999-09-30

    An interlaboratory comparison exercise for {sup 129}I was organized and conducted. Nine laboratories participated in the exercise to either a full or limited extent. In Phase I of the comparison, 11 samples were measured. The suite of samples contained both synthetic ''standard type'' materials (i.e., AgI) and environmental materials. The isotopic {sup 129}I/{sup 127}I ratios of the samples varied from 10{sup {minus}8} to 10{sup {minus}14}. In this phase, each laboratory was responsible for its own chemical preparation of the samples. In Phase I, the {sup 129}I AMS measurements for prepared AgI were in good agreement. However, large discrepancies were seen in {sup 129}I AMS measurements of environmental samples. Because of the large discrepancies seen in the Phase I {sup 129}I intercomparison, a subsequent study was conducted. In Phase II of the {sup 129}I intercomparison, three separate laboratories prepared AgI from two environmental samples (IAEA 375 soil and maples leaves). Each laboratory used its own chemical preparation method with each of the methods being distinctly different. The resulting six samples (two sets of three) were then re-distributed to the participating {sup 129}I AMS facilities and {sup 129}I/{sup 127}I ratios measured. Results and discussion of both the Phase I and Phase II interlaboratory comparison are presented.

  15. Amarcord: I Remember

    PubMed Central

    Carafoli, Ernesto

    2013-01-01

    I have tried to offer a historical account of a success story, as I saw it develop from the early times when it interested only a few aficionados to the present times when it has pervaded most of cell biochemistry and physiology. It is of course the story of calcium signaling. It became my topic of work when I was a young postdoctoral fellow at The Johns Hopkins University. I entered it through a side door, that of mitochondria, which had been my area of work during my earlier days in Italy. The 1960s and 1970s were glorious times for mitochondrial calcium signaling, but the golden period was not going to last. As I have discussed below, mitochondrial calcium gradually lost appeal, entering a long period of oblivion. Its fading happened as the general area of calcium signaling was instead experiencing a phase of explosive growth, with landmark discoveries at the molecular and cellular levels. These discoveries established that calcium signaling was one of the most important areas of cell biology. However, mitochondria as calcium partners were not dead; they were only dormant. In the 1990s, they were rescued from their state of neglect to the central position of the regulation of cellular calcium signaling, which they had once rightly occupied. Meanwhile, it had also become clear that calcium is an ambivalent messenger. Hardly anything important occurs in cells without the participation of the calcium message, but calcium must be controlled with absolute precision. This is an imperative necessity, which becomes unfortunately impaired in a number of disease conditions that transform calcium into a messenger of death. PMID:23836917

  16. Multiple endocrine neoplasia (MEN) I

    MedlinePlus

    Wermer syndrome; MEN I ... MEN I is caused by a defect in a gene that carries the code for a protein called menin. ... your provider if you notice symptoms of MEN I or have a family history of this condition.

  17. Near-complete genome sequence of the cellulolytic Bacterium <i>Bacteroides> (<i>Pseudobacteroides>) <i>cellulosolvens> ATCC 35603

    SciTech Connect

    Dassa, Bareket; Utturkar, Sagar M.; Hurt, Richard A.; Klingeman, Dawn Marie; Keller, Martin; Xu, Jian; Reddy, Harish Kumar; Borovok, Ilya; Grinberg, Inna Rozman; Lamed, Raphael; Zhivin, Olga; Bayer, Edward A.; Brown, Steven D.

    2015-09-24

    We report the single-contig genome sequence of the anaerobic, mesophilic, cellulolytic bacterium, <i>Bacteroides cellulosolvensi>. The bacterium produces a particularly elaborate cellulosome system, whereas the types of cohesin-dockerin interactions are opposite of other known cellulosome systems: cell-surface attachment is thus mediated via type-I interactions whereas enzymes are integrated via type-II interactions.

  18. 78 FR 39436 - Temporary Closure of I-65 (I-70/I-65 South Split Interchange to I-70/I-65 North Split Interchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... TRANSPORTATION Federal Highway Administration Temporary Closure of I-65 (I-70/I-65 South Split Interchange to I-70/I-65 North Split Interchange) in the City of Indianapolis AGENCIES: Federal Highway Administration... (INDOT) has requested FHWA approval of INDOT's proposed plan to close a 2-mile portion of I- 65...

  19. Average and local crystal structures of (Ga1–<i>xi>Znx>)(N1–<i>xOx>) solid solution nanoparticles

    SciTech Connect

    Feygenson, Mikhail; Neuefeind, Joerg C.; Tyson, Trevor A.; Schieber, Natalie; Han, Wei -Qiang

    2015-11-06

    We report the comprehensive study of the crystal structure of (Ga1–<i>xi>Znx>)(N1–<i>xOx>) solid solution nanoparticles by means of neutron and synchrotron x-ray scattering. In our study we used four different types of (Ga1–<i>xi>Znx>)(N1–<i>xOx>) nanoparticles, with diameters of 10–27 nm and x = 0.075–0.51, which show the narrow energy-band gaps from 2.21 to 2.61 eV. The Rietveld analysis of the neutron diffraction data revealed that the average crystal structure is the hexagonal wurtzite (space group P63mc), in agreement with previous reports on similar bulk materials. The pair-distribution function (PDF) analysis of the same data found that the local structure is more disordered than the average one. It is best described by the model with a lower symmetry space group P1, where atoms are quasirandomly distorted from their nominal positions in the hexagonal wurtzite lattice.

  20. Fermentation of dilute acid pretreated <i>Populus> by <i>Clostridium thermocellumi>, <i>Caldicellulosiruptor besciii>, and <i>Caldicellulosiruptor obsidiansisi>

    SciTech Connect

    Yee, Kelsey L.; Rodriguez, Jr., Miguel; Hamilton, Choo Yieng; Hamilton-Brehm, Scott D.; Thompson, Olivia A.; Elkins, James G.; Davison, Brian H.; Mielenz, Jonathan R.

    2015-07-25

    Consolidated bioprocessing (CBP), which merges enzyme production, biomass hydrolysis, and fermentation into a single step, has the potential to become an efficient and economic strategy for the bioconversion of lignocellulosic feedstocks to transportation fuels or chemicals. In this study, we evaluated <i>Clostridium thermocellumi>, <i>Caldicellulosiruptor besciii>, and <i>Caldicellulosiruptor obsidiansisi>, three , thermophilic,cellulolytic, mixed-acid fermenting candidate CBP microorganisms, for their fermentation capabilities using dilute acid pretreated <i>Populus> as a model biomass feedstock. Under pH controlled, anaerobic fermentation conditions, each candidate successfully digested a minimum of 75% of the cellulose from dilute acid pretreated <i>Populus>, as indicated by an increase in planktonic cells and end-product metabolites and a concurrent decrease in glucan content. <i>C. thermocellumi>, which employs a cellulosomal approach to biomass degradation, required 120 hours to achieve 75% cellulose utilization. In contrast, the non-cellulosomal, secreted hydrolytic enzyme system of the <i>Caldicellulosiruptor> sp. required 300 hours to achieve similar results. End-point fermentation conversions for <i>C. thermocellumi>, <i>C. besciii>, and <i>C. obsidiansisi> were determined to be 0.29, 0.34, and 0.38 grams of total metabolites per gram of loaded glucan, respectively. This data provide a starting point for future strain engineering efforts that can serve to improve the biomass fermentation capabilities of these three promising candidate CBP platforms.

  1. 129I interlaboratory comparison: phase I and phase II results

    SciTech Connect

    Roberts, M.I.; Caffee, M.W.; Proctor, I.D.

    1997-07-01

    An interlaboratory comparison exercise for 129I was organized and conducted. A total of nine laboratories participated in the exercise to either a full or limited extent. In Phase I of the comparison, a suite of 11 samples were measured. The suite of samples contained both synthetic `standard type` materials (i.e., AgI) and environmental materials. The isotopic 129I/127I ratios of the samples varied from 10`-8 to 10`-14. In this phase, each laboratory was responsible for its own chemical preparation of the environmental samples. The 129I AMS measurements obtained at different laboratories for prepared AgI were in good agreement. However, large discrepancies were seen in 129I AMS measurements of environmental samples. Because of the large discrepancies seen in the Phase I intercomparison, a subsequent study was conducted. In Phase II of the comparison, AgI was prepared from two environmental samples (IAEA 375 soil and maples leaves) by three separate laboratories. Each laboratory used its own chemical preparation method with each of the methods being distinctly different. The resulting six samples (two sets of three) were then redistributed to the participating 129I AMS facilities and 129I/127I ratios measured. Results and discussion of both the Phase I and Phase II interlaboratory comparison are presented.

  2. Father and I

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Father (K. C. Yang (楊克純), 1896-1973) was a high school teacher in Anqing (安慶) in 1922 when I was born in Hefei (合肥). Anqing was then also called Huaining (懷寧). Father gave me the name Chen Ning, of which Chen was the name of my generation in our family, and Ning was derived from Huaining. Before I was one year old Father won an Anhui (安徽) Provincial Fellowship for studying in the USA. We had a family picture (Figure 1) taken in the courtyard outside our bedroom a few days before he left home. Father had on the traditional robe and coat, standing stiff and erect. He had probably up to that point never worn a western suit. Two years later he sent a picture (Figure 2) to Mother from the University of Chicago, in which his attire and bearing had both entered the twentieth century. Father was a handsome man. The exuberance and optimism of his youth were clearly captured in this photograph...

  3. Adding Zingers to Course I.

    ERIC Educational Resources Information Center

    Kalman, Richard

    1996-01-01

    This article presents problems to challenge students over and above the standard curriculum problems assigned at a Course I level. Every additional problem in the article can be solved using only the tools provided by Course I. (AIM)

  4. Metabolomic profiling of the nectars of <i>Aquilegia pubescensi> and <i>A. Canadensisi>

    SciTech Connect

    Noutsos, Christos; Perera, Ann M.; Nikolau, Basil J.; Seaver, Samuel M. D.; Ware, Doreen H.; Motta, Andrea

    2015-05-01

    To date, variation in nectar chemistry of flowering plants has not been studied in detail. Such variation exerts considerable influence on pollinator–plant interactions, as well as on flower traits that play important roles in the selection of a plant for visitation by specific pollinators. Over the past 60 years the <i>Aquilegia> genus has been used as a key model for speciation studies. In this study, we defined the metabolomic profiles of flower samples of two <i>Aquilegia> species, <i>A. Canadensisi> and <i>A. pubescensi>. We identified a total of 75 metabolites that were classified into six main categories: organic acids, fatty acids, amino acids, esters, sugars, and unknowns. The mean abundances of 25 of these metabolites were significantly different between the two species, providing insights into interspecies variation in floral chemistry. Using the PlantSEED biochemistry database, we found that the majority of these metabolites are involved in biosynthetic pathways. Finally, we explored the annotated genome of <i>A. coeruleai>, using the PlantSEED pipeline and reconstructed the metabolic network of <i>Aquilegia>. This network, which contains the metabolic pathways involved in generating the observed chemical variation, is now publicly available from the DOE Systems Biology Knowledge Base (KBase; http://kbase.us).

  5. Planning for RtI

    ERIC Educational Resources Information Center

    Robins, Jennifer; Antrim, Patricia

    2013-01-01

    In 2004 the Individuals with Disabilities Education Act authorized funding for Response to Intervention (RtI) instruction in the United States. By 2011, 71 percent of school districts had adopted RtI (Institute of Education Sciences 2011). The goal of RtI is to provide personalized, just-in-time intervention in reading and math for students who…

  6. A Title I Refinement: Alaska.

    ERIC Educational Resources Information Center

    Hazelton, Alexander E.; And Others

    Through joint planning with a number of school districts and the Region X Title I Technical Assistance Center, and with the help of a Title I Refinement grant, Alaska has developed a system of data storage and retrieval using microcomputers that assists small school districts in the evaluation and reporting of their Title I programs. Although this…

  7. Pearl I. Young

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Pearl I Young at the NACA Langley Instrument Research Laboratory. She was the Chief Technical Editor at Langley. Pearl Young attended Jamestowm College and the University of North Dakota, graduating in 1919 with honors, a Phi Beta Kappa key and a triple major in physics, chemistry and mathematics. She was hired by the University to teach physics, a role that typically was served by men. In 1921, there were 21 female and 864 male physicists in the United States. Most of the women were college teachers, hired by women's colleges. There was only one woman physicist working for the federal government at that time, and she worked for the National Bureau of Standards. In 1922 Young was hired as a physicist by the National Advisory Committee for Aeronautics (NACA), and was assigned to the Langley Memorial Aeronautical Laboratory's Instrument Research Division under the direction of Henry J.E. Reid. In 1929 Reid appointed Young as Langley's Chief Technical Editor. She established a 'new' office, hired staff and formed the research reports and offical documents that communicated the extraordinary technical accomplishments of Langley. Over her twenty eight years at the NACA and NASA, Young helped define the public image of the NACA and influenced the way aeronautical engineers throughtout NACA (now NASA) communicate their ideas.

  8. THE GENUS VEILLONELLA I.

    PubMed Central

    Rogosa, M.

    1964-01-01

    Rogosa, M. (National Institutes of Health, Bethesda, Md.). The genus Veillonella. I. General cultural, ecological, and biochemical considerations. J. Bacteriol. 87:162–170. 1964.—Arguments are presented for excluding Veillonella discoides, V. reniformis, V. orbiculus, and V. vulvovaginitidis from the genus, and for restricting it to aerogenic organisms such as V. parvula and V. alcalescens. The genus Veillonella thus would comprise species which are anaerobic and nonmotile; are small, spherical, gram-negative cocci appearing as pairs, masses, and short chains; and are cytochrome-oxidase- and benzidine-negative. Veillonella would be further characterized in that glucose or any other carbohydrate is not fermented; indole is not produced; gelatin is not liquefied; nitrate is reduced; H2S is produced; propionic and acetic acids, CO2, and H2 are produced from lactate during growth; and pyruvic, oxaloacetic, malic, fumaric, and succinic acids are metabolized by resting cells, but citric, isocitric, and malonic acids are not. In addition to the above, a number of cultural, ecological, and biochemical characteristics are described. At present, V. parvula (the type species) and V. alcalescens would be retained as valid species. Errors in the descriptions of V. parvula and V. alcalescens are corrected by amended statements. These species are differentiated serologically. Also, V. alcalescens differs from V. parvula in having an absolute requirement for putrescine or cadaverine and in decomposing H2O2. PMID:14102850

  9. 'Who am I?'.

    PubMed

    Schellinski, Kristina

    2014-04-01

    The dreams and existential questions of those, who came into being in order to replace a dead person, pivot around a central cry: 'Who am I?' If conceived, born or designated as a replacement child, such an individual may suffer-even as an adult-from a rarely recognized unconscious confusion of identity, compounded by grief and survivors' guilt. From before the child is born, the archetypal forces of death and life are joined in a fateful constellation; the soul of the replacement child bears the shadow of death from the very beginning of life. Hope for the replacement child lies in an emergence of true self as soul recreates original life. Analysis can help the replacement child experience a 'rebirth into true life', not as 'the one who returned', but as a psychologically newborn individual; the path of individuation countering the replacement child's identification with the dead. Jungian analysis offers unique concepts for understanding and healing the replacement child; C.G. Jung himself was born after two stillborn babies and an infant that lived only five days. PMID:24673274

  10. Find Quality Resources: How Do I Know if I Can Trust the Informaton I Find Online?

    MedlinePlus

    ... Your Medical Record Support family caregivers Find Quality Resources How do I know if I can trust ... Food and Drug Administration . Are the tools or resources easily usable? On a web site, is it ...

  11. {sup 129}I interlaboratory comparison

    SciTech Connect

    Roberts, M.L.; Caffee, M.W.; Proctor, L.D.

    1996-05-01

    An interlaboratory comparison exercise for {sup 129}I has been organized and conducted. A total of seven laboratories participated in the exercise to either a full or limited extent. In the comparison, a suite of 11 samples were used. This suite of standards contained both synthetic `standard type` materials(i.e., AgI) and environmental materials. The isotopic {sup 129}I/{sup 127}I ratio of the samples varied from 10{sup -8} to 10{sup -14}. Preliminary results of the comparison are presented.

  12. S. S. Chern and I

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    I do not remember whether I had met Prof. S. S. Chern when he was a graduate student of Tsinghua University in Peking (now Beijing) where my father was a mathematics professor, and I was in elementary school. But I do remember how I had met Mrs. Chern for the first time, in early October, 1929, when I was seven years old and she was in junior high school. Her father, Professor Tsen, had been a professor of Mathematics at Tsinghua University already for a number of years, and the Yangs were new comers that fall. The Tsens invited us to their house for dinner and that was when I first made the acquaintence of "big sister Tsen"...

  13. Am I Doing Anything Wrong?

    NASA Astrophysics Data System (ADS)

    Chang, Eun-Woo

    1998-04-01

    Absolutely not! Let me be more specific. Am I doing anything I do not want to do with my career? I don't think so. Am I satisfied? My initial career goal was to teach at a small four-year university and do research with undergraduate students. But I am more than satisfied with what I am doing now, and I am enjoying my job. It is true that many new and talented Ph.D.'s are currently looking for careers at two-year colleges instead of universities. Many people expect this trend will be even greater in the future. Surveys also show that younger people (20-30's) care a great deal about both family and career. Thus, a teaching job at a two-year college is ideal for them. It was quite a surprise to find that many of my friends, who are very talented in research, are now teaching at two-year colleges.

  14. Frontiers of <i>in situi> electron microscopy

    SciTech Connect

    Zheng, Haimei; Zhu, Yimei; Meng, Shirley Ying

    2015-01-01

    <i>In situi> transmission electron microscopy (TEM) has become an increasingly important tool for materials characterization. It provides key information on the structural dynamics of a material during transformations and the correlation between structure and properties of materials. With the recent advances in instrumentation, including aberration corrected optics, sample environment control, the sample stage, and fast and sensitive data acquisition, in situ TEM characterization has become more and more powerful. In this article, a brief review of the current status and future opportunities of in situ TEM is included. It also provides an introduction to the six articles covered by in this issue of <i>MRS Bulletini> explore the frontiers of <i>in situi> electron microscopy, including liquid and gas environmental TEM, dynamic four-dimensional TEM, nanomechanics, ferroelectric domain switching studied by <i>in situi> TEM, and state-of-the-art atomic imaging of light elements (i.e., carbon atoms) and individual defects.

  15. 129I in Missouri thyroids.

    PubMed

    Oliver, L L; Ballad, R V; Manuel, O K

    1982-04-01

    Concentrations of 129I and values of the 129I/127I ration are reported in one sample of indigenous vegetation and in over forty additional individual thyroids of man, wild deer and beef cattle in Missouri. The results of this and other studies in our laboratory indicate the following order for successively lower values of 129I/127I ratios in the local environment: Rain, wild deer, commercial milk, beef cattle and human. The value of the 129I/127I ratio in the single vegetation sample is intermediate to the mean values in wild deer and commercial milk, but well within the range of values observed in both. These results are consistent with a geochemical cycle in which iodine that is enriched in 129I is transported via air into the central U.S. and then diluted with other iodine--especially mineral iodine that is added to the diets of domesticated animals--as the iodine deposited from air moves through the local ecosystem. Differences in the diets of beef and dairy cattle or differences in the biological life-times of iodine in thyroids and mammae, and hence the degree of equilibration with body iodine, may explain the lower value of the 129I/127I ratio in beef thyroids than in milk.

  16. Complete genome sequence of <i>Planctomyces brasiliensisi> type strain (DSM 5305T), phylogenomic analysis and reclassification of <i>Planctomycetes> including the descriptions of <i>Gimesia> gen. nov.,<i> Planctopirusi> gen. nov. and <i>Rubinisphaera> gen. nov. and emended descriptions of the order <i>Planctomycetales> and the family <i>Planctomycetaceae>

    SciTech Connect

    Scheuner, Carmen; Tindall, Brian J.; Lu, Megan; Nolan, Matt; Lapidus, Alla L.; Cheng, Jan-Fang; Goodwin, Lynne A.; Pitluck, Sam; Huntemann, Marcel; Liolios, Konstantinos; Pagani, Ioanna; Mavromatis, Konstantinos; Ivanova, Natalia; Pati, Amrita; Chen, Amy; Palaniappan, Krishna; Jeffries, Cynthia D.; Hauser, Loren John; Land, Miriam L.; Mwirichia, Romano; Rohde, Manfred; Abt, Birte; Detter, John Chris; Woyke, Tanja; Eisen, Jonathan A.; Markowitz, Victor; Hugenholtz, Philip; Goker, Markus; Kyrpides, Nikos C.; Klenk, Hans-Peter

    2014-12-08

    <i>Planctomyces brasiliensisi> Schlesner 1990 belongs to the order <i>Planctomycetales>, which differs from other bacterial taxa by several distinctive features such as internal cell compartmentalization, multiplication by forming buds directly from the spherical, ovoid or pear-shaped mother cell and a cell wall consisting of a proteinaceous layer rather than a peptidoglycan layer. The first strains of <i>P. brasiliensisi>, including the type strain IFAM 1448 T, were isolated from a water sample of Lagoa Vermelha, a salt pit near Rio de Janeiro, Brasil. This is the second completed genome sequence of a type strain of the genus <i>Planctomyces> to be published and the sixth type strain genome sequence from the family <i>Planctomycetaceae>. The 6,006,602 bp long genome with its 4,811 protein-coding and 54 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project. We study phylogenomic analyses that indicate that the classification within the <i>Planctomycetaceae> is partially in conflict with its evolutionary history, as the positioning of <i>Schlesneria> renders the genus <i>Planctomyces> paraphyletic. A re-analysis of published fatty-acid measurements also does not support the current arrangement of the two genera. A quantitative comparison of phylogenetic and phenotypic aspects indicates that the three <i>Planctomyces> species with type strains available in public culture collections should be placed in separate genera. Thus the genera <i>Gimesia, Planctopirusi> and <i>Rubinisphaera> are proposed to accommodate <i>P. maris, P. limnophilusi> and <i>P. brasiliensisi>, respectively. Pronounced differences between the reported G + C content of <i>Gemmata obscuriglobus, Singulisphaera acidiphilai> and <i>Zavarzinella formosai> and G + C content calculated from their genome sequences call for emendation of their species descriptions. Lastly, in addition to other features, the range of G + C values reported for

  17. Praxis I/O package

    SciTech Connect

    Holloway, F.W.; Sherman, T.A.

    1988-04-07

    The Praxis language specification, like Algol and Ada, does not specify any I/O statements. The intent was to provide a standard I/O package as a companion to the compiler. This would allow the user to substitute, or supplement, the I/O package, as needed, for specialized applications. Like Algol, however, Praxis provided only limited (text) I/O for several years. Ada, in contrast, provided a comprehensive standard I/O package from its inception. Digital Equipment Corporation's (DEC's) implementation of Ada, on their VAX family of computers, further supplemented this package with other packages which exploit the I/O facilities available under the VMS operating system. The Praxis I/O package described in this document has been modeled after DEC's implementation of Ada and provides a similar set of I/O facilities. Currently, the I/O package is supported only under VAX/VMS. The design of the package, however, is essentially independent of any operating system (with the exception of the module COMMAND IO). The VAX/VMS version of the I/O package fully exploits the vast I/O facilities which are provided under VAX/VMS and makes them directly available to the Praxis programmer. The design, prototype implementation, and draft documentation of the Praxis I/O Package was done by Tim Sherman as part of a University project in computer science. Subsequent work by both Tim and Fred Holloway lead to a more complete implementation, testing and development of example programs, and inclusion of the package into the Praxis compilers as their principal interface to RMS and VMS.

  18. The NO<i>v>A simulation chain

    SciTech Connect

    Aurisano, A.; Backhouse, C.; Hatcher, R.; Mayer, N.; Musser, J.; Patterson, R.; Schroeter, R.; Sousa, A.

    2015-12-23

    The NO<i>v>A experiment is a two-detector, long-baseline neutrino experiment operating in the recently upgraded NuMI muon neutrino beam. Simulating neutrino interactions and backgrounds requires many steps including: the simulation of the neutrino beam flux using FLUKA and the FLUGG interface, cosmic ray generation using CRY, neutrino interaction modeling using GENIE, and a simulation of the energy deposited in the detector using GEANT4. To shorten generation time, the modeling of detector-specific aspects, such as photon transport, detector and electronics noise, and readout electronics, employs custom, parameterized simulation applications. We will describe the NO<i>v>A simulation chain, and present details on the techniques used in modeling photon transport near the ends of cells, and in developing a novel data-driven noise simulation. Due to the high intensity of the NuMI beam, the Near Detector samples a high rate of muons originating in the surrounding rock. In addition, due to its location on the surface at Ash River, MN, the Far Detector collects a large rate ((˜) 140 kHz) of cosmic muons. Furthermore, we will discuss the methods used in NO<i>v>A for overlaying rock muons and cosmic ray muons with simulated neutrino interactions and show how realistically the final simulation reproduces the preliminary NO<i>v>A data.

  19. Ares I Ares V Overview

    NASA Technical Reports Server (NTRS)

    Sumrall, Phil

    2009-01-01

    This slide presentation is an overview of the Ares I and Ares V projects. It includes a comparison of the launch vehicles from the Saturn V, the Space Shuttle, and the planned Ares I and Ares V. In order to reduce operating cost, the Ares and V will use much of the same hardware. The elements of the Ares I and V. are reviewed and there is a view of the upper stage avionics. The elements of the J-2X engine to be used on both the Ares I and V are viewed.

  20. Spectroscopic Data of W I, Mo I and Cr I Spectral Lines: Selection and Analysis

    NASA Astrophysics Data System (ADS)

    Veklich, A. N.; Lebid, A. V.; Tmenova, T. A.

    2015-12-01

    Plasma of electric arc discharges between composite Cu-W, Cu-Mo and Cu-Cr electrodes in argon flow and their spectra were studied by optical emission spectroscopy. Since values of oscillator strengths for W I, Mo I and Cr I presented in various sources are significantly different, selection of spectroscopic data for these elements (particularly oscillator strength) was expected to be useful for plasma diagnostics. The Boltzmann plot method was used as a tool for the selection of appropriate spectral lines and their spectroscopic data. The main result of the paper is W I, Mo I and Cr I spectral lines and spectroscopic data recommended for diagnostics of plasma with such metal impurities.

  1. iNACOL Research Agenda

    ERIC Educational Resources Information Center

    International Association for K-12 Online Learning, 2013

    2013-01-01

    The International Association for K-12 Online Learning (iNACOL) publishes a research agenda on an ongoing basis to continue its work in field-building, capacity-building and knowledge-building. Based on a 2013 survey of the field to identify research needs, iNACOL developed a research approach, including the following: (1) Build a collaborative…

  2. Why Am I So Sad?

    MedlinePlus

    ... Chloe & Nurb Meet The Brain (Movie) Quiz: Do You Need a Flu Shot? Got Homework? Here's Help White House Lunch Recipes Why Am I So Sad? KidsHealth > For Kids > Why Am I So Sad? ... Do Kids Feel Sad About? Are Sad Feelings Normal? How Can You Deal With Sad Feelings? en español ¿Por qué ...

  3. Seeing I to I: A Pathway to Interpersonal Connectedness

    PubMed Central

    Pinel, Elizabeth C.; Long, Anson E.; Landau, Mark J.; Alexander, Kira; Pyszczynski, Tom

    2009-01-01

    The authors introduce the construct of I-sharing—the belief that one shares an identical subjective experience with another person—and the role it plays in liking. In Studies 1–3, participants indicated their liking for an objectively similar and an objectively dissimilar person, one of whom I-shared with them and the other of whom did not. Participants preferred the objectively similar person but only when that person I-shared with them. Studies 4 and 5 highlight the role that feelings of existential isolation and the need for closeness play in people’s attraction to I-sharers. In Study 4, people with high needs for interpersonal closeness responded to I-sharers and non-I-sharers with great intensity. In Study 5, priming participants with feelings of existential isolation increased their liking for I-sharers over objectively similar others. The results highlight the importance of shared subjective experience and have implications for interpersonal and intergroup processes. PMID:16536649

  4. ROOT I/O Improvements

    NASA Astrophysics Data System (ADS)

    Canal, Ph

    2012-12-01

    In the past year, the development of ROOT I/O has focused on improving the existing code and increasing the collaboration with the experiments’ experts. Regular I/O workshops have been held to share and build upon the various experiences and points of view. The resulting improvements in ROOT I/O span many dimensions including reduction and more control over the memory usage, reduction in CPU usage as well as optimization of the file size and the hardware I/O utilization. Many of these enhancements came as a result of an increased collaboration with the experiments’ development teams and their direct contributions both in code and quarterly ROOT I/O workshops.

  5. There is no I/O like no I/O. [Computer I/O performance

    SciTech Connect

    Johnston, T.Y.

    1985-01-01

    On most computer systems the most common cause of performance degradation is I/O contention. This paper will examine some efforts that can be taken in a VM environment to reduce I/O or its effect at both the global and local levels.

  6. 'I hope that I get old before I die': ageing and the concept of disease.

    PubMed

    Schramme, Thomas

    2013-06-01

    Ageing is often deemed bad for people and something that ought to be eliminated. An important aspect of this normative aspect of ageing is whether ageing, i.e., senescence, is a disease. In this essay, I defend a theory of disease that concludes that ageing is not a disease, based on an account of natural function. I also criticize other arguments that lead to the same conclusion. It is important to be clear about valid reasons in this debate, since the failure of bad analyses is exploited by proponents of the view that ageing is indeed a disease. Finally, I argue that there could be other reasons for attempting to eradicate senescence, which have to do with an evaluative assessment of ageing in relation to the good life. I touch on some reasons why ageing might be good for people and conclude that we cannot justify generalized statements in this regard.

  7. Neutral dissociation of the I, I', and I" vibronic progressions of O2.

    PubMed

    Demekhin, Ph V; Sukhorukov, V L; Schmoranzer, H; Ehresmann, A

    2010-05-28

    It is suggested that the main mechanism for neutral dissociation of the I, I('), and I(") vibronic progressions in O(2) is due to their interaction with the vibrational continuum of the 1pi(u) (-1)(A (2)Pi(u))3ssigma(g) (3)Pi(u)(v(epsilon)) Rydberg state (J state) leading to the formation of the O(2p(4) (3)P)+O( *)(2p(3)((4)S)3s (3)S) fragments. In order to justify this, the O I 2p(3)((4)S)3s (3)S-->2p(4) (3)P fluorescence emission cross section following the neutral dissociation of the O(2) 1pi(u) (-1)(a (4)Pi(u))4ssigma(g)/3ddelta(g)/3dsigma(g) (3)Pi(u)(v) Rydberg states is simulated in the exciting-photon energy range of 14.636-16.105 eV. The results of high-resolution measurements (H. Liebel et al., J. Phys. B 34, 2581 (2001)) can be reproduced if a small adjustment of the computed potential curve of the J state is applied. Non-Franck-Condon resonant intensity distributions of the I, I('), and I(") progressions observed in the experiment are qualitatively explained by the presence of the O(2) 1pi(g) (-1)(X (2)Pi(g))npsigma(u)/nfsigma(u)/nfdelta(u) (3)Pi(u) perturber states. Present calculations allow to decide between two different assignments of the I, I('), and I(") states available in literature.

  8. Rockets in World War I

    NASA Technical Reports Server (NTRS)

    2004-01-01

    World War I enlisted rockets once again for military purposes. French pilots rigged rockets to the wing struts of their airplanes and aimed them at enemy observation balloons filled with highly inflammable hydrogen.

  9. Teaching with iPads

    NASA Astrophysics Data System (ADS)

    Maj, Hubert

    2015-04-01

    Bilingual students in high school with bilingual units in Boguchwała have received iPads for learning English and a few subjects using CLIL (biology, basics of entrepreneurship, geography, IT and mathematics). Lessons with iPads are interesting for students for several reasons. First of all, teenagers like new technologies and using iPads for teaching helps students to learn by fun. Secondly, iPads give new possibilities of looking for knowledge about each theme. Moreover, teaching with iPads develops students' engagement. They have a chance to choose a few among over 65 000 applications for gathering and then presenting information about the lesson topic. They can easily prepare presentations, movies, cartoons, mind maps or whatever they like. Teaching students, thanks to the iPads, makes it their initiative, and the teacher can inspire them to look for the knowledge rather than disciplining pupils. But teaching with iPads is connected with many problems. For instance, there are not any examples on how to teach using these tools. It is very up-to-date technology and teachers firstly must learn the possibilities of iPads and look for new applications. It takes much time, especially at the beginning, and is difficult especially for inexperienced teachers. In addition, it is almost impossible to maintain control of the iPads for all of the students during the lesson. They can use their iPads for something unconnected with the topic of the lesson. Thirdly is lack of time - active methods (with iPads as well) are more time-consuming and it could be that they do not finish the whole program. And of course the last, but not at least, is the problem of money. Some of the applications must be paid for, and it is usually obligatory to possess a credit card. Fortunately, it is not expensive - applications usually cost a few euros and many of them are free and really good.

  10. Graphs for 53-I (Iodine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume A `Nuclei with Z = 1 - 54' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms'. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 53-I (Iodine, atomic number Z = 53).

  11. Draft genome sequences of four <i>Streptomyces> isolates from the <i>Populus trichocarpai> root endosphere and rhizosphere

    SciTech Connect

    Klingeman, Dawn M.; Utturkar, Sagar; Lu, Tse -Yuan S.; Schadt, Christopher W.; Pelletier, Dale A.; Brown, Steve D.

    2015-11-12

    Draft genome sequences for four Actinobacteria from the genus <i>Streptomyces> are presented. <i>Streptomyces> is a metabolically diverse genus that is abundant in soils and has been reported in association with plants. The strains described in this study were isolated from the <i>Populus trichocarpai> endosphere and rhizosphere.

  12. Genome sequence and annotation of <i>Trichoderma parareeseii>, the ancestor of the cellulase producer <i>Trichoderma reeseii>

    SciTech Connect

    Yang, Dongqing; Pomraning, Kyle; Kopchinskiy, Alexey; Karimi, Aghcheh Razieh; Atanasova, Lea; Chenthamara, Komal; Baker, Scott E.; Zhang, Ruifu; Shen, Qirong; Freitag, Michael; Kubicek, Christian P.; Druzhinina, Irina S.

    2015-08-13

    The filamentous fungus <i>Trichoderma parareeseii> is the asexually reproducing ancestor of <i>Trichoderma reeseii>, the holomorphic industrial producer of cellulase and hemicellulase. Here, we present the genome sequence of the <i>T. parareeseii> type strain CBS 125925, which contains genes for 9,318 proteins.

  13. Hyperinsulinism in tyrosinaemia type I.

    PubMed

    Baumann, U; Preece, M A; Green, A; Kelly, D A; McKiernan, P J

    2005-01-01

    Tyrosinaemia type I (TT I) (McKusick 276700) is a heterogeneous disorder with a broad spectrum of clinical phenotypes. Although histological abnormalities of the pancreas are well recognized, there are only incidental reports of pancreatic dysfunction manifested as insulin-dependent diabetes mellitus. We report three subjects with TT I and acute liver dysfunction who had hyperinsulinism in early infancy. Hypoglycaemia persisted despite dietary treatment and one patient had inadequate lipolysis at the time of hypoglycaemia. All three patients were successfully treated with diazoxide (10 mg/kg per day) and chlorthiazide (35 mg/kg per day) and treatment was gradually withdrawn after 9, 13 and 34 months, respectively. The mechanism of pancreatic dysfunction in TT I is unknown but may be related to the toxic metabolites that accumulate in this condition. We conclude that hyperinsulinism is not a rare complication in TT I. In patients with persistent hypoglycaemia, C-peptide should always be measured. Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong. PMID:15877201

  14. Hyperinsulinism in tyrosinaemia type I.

    PubMed

    Baumann, U; Preece, M A; Green, A; Kelly, D A; McKiernan, P J

    2005-01-01

    Tyrosinaemia type I (TT I) (McKusick 276700) is a heterogeneous disorder with a broad spectrum of clinical phenotypes. Although histological abnormalities of the pancreas are well recognized, there are only incidental reports of pancreatic dysfunction manifested as insulin-dependent diabetes mellitus. We report three subjects with TT I and acute liver dysfunction who had hyperinsulinism in early infancy. Hypoglycaemia persisted despite dietary treatment and one patient had inadequate lipolysis at the time of hypoglycaemia. All three patients were successfully treated with diazoxide (10 mg/kg per day) and chlorthiazide (35 mg/kg per day) and treatment was gradually withdrawn after 9, 13 and 34 months, respectively. The mechanism of pancreatic dysfunction in TT I is unknown but may be related to the toxic metabolites that accumulate in this condition. We conclude that hyperinsulinism is not a rare complication in TT I. In patients with persistent hypoglycaemia, C-peptide should always be measured. Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong.

  15. Development of new UV-I. I. Cerenkov Viewing Device

    SciTech Connect

    Kuribara, Masayuki; Nemoto, Koshichi . Communication and Information Research Lab.)

    1994-02-01

    The Cerenkov glow images from boiling-water reactors (BWR) and pressurized-water reactors (PWR) irradiated fuel assemblies are generally used for inspections. However, sometimes it is difficult or impossible to identify the image by the conventional Cerenkov Viewing Device (CVD), because of the long cooling time and/or low burnup. Now a new UV-I.I. (Ultra-Violet light Image Intensifier) CVD has been developed, which can detect the very weak Cerenkov glow from spent fuel assemblies. As this new device uses the newly developed proximity focused type UV-I.I., Cerenkov photons are used efficiently, producing better quality Cerenkov glow images. Moreover, since the image is converted to a video signal, it is easy to improve the signal to noise ratio (S/N) by an image processor. The new CVD was tested at BWR and PWR power plants in Japan, with fuel burnups ranging from 6,200--33,000 MWD/MTU (megawatt days per metric ton of uranium) and cooling times ranging from 370 to 6,200 d. The tests showed that the new CVD is superior to the conventional STA/CRIEPI CVD, and could detect very feeble Cerenkov glow images using an image processor.

  16. [Type I interferonopathies].

    PubMed

    Munoz, J; Marque, M; Dandurand, M; Meunier, L; Crow, Y-J; Bessis, D

    2015-11-01

    Type I interferonopathies are a group of Mendelian disorders characterized by a common physiopathology: the up-regulation of type I interferons. To date, interferonopathies include Aicardi-Goutières syndrome, familial chilblain lupus, spondyenchondromatosis, PRoteasome-associated auto-inflammatory syndrome (PRAAS) and Singleton-Merten syndrome. These diseases present phenotypic overlap including cutaneous features like chilblain lupus, that can be inaugural or present within the first months of life. This novel set of inborn errors of immunity is evolving rapidly, with recognition of new diseases and genes. Recent and improved understanding of the physiopathology of overexpression of type I interferons has allowed the development of targeted therapies, currently being evaluated, like Janus-kinases or reverse transcriptase inhibitors. PMID:26363997

  17. Radiative lifetimes in Co I

    NASA Astrophysics Data System (ADS)

    Nitz, D. E.; Bergeson, S. D.; Lawler, J. E.

    1995-03-01

    New radiative-lifetime measurements based on time-resolved laser-induced fluorescence are reported for 133 odd-parity and 2 even-parity levels of Co I, ranging in energy from 28300 to 59400 cm-1. Our lifetimes agree with earlier, but much less extensive, lifetime measurements based on laser-induced fluorescence. Satisfactory agreement is also found with the critical compilation of atomic transition probabilities from the U.S. National Bureau of Standards [J. Phys. Chem. Ref. Data 17, Suppl 4 (1988)]. Our measurements provide a reliable absolute normalization for a much more comprehensive determination of Co I atomic transition probabilities.

  18. HAWK-I Takes Off

    NASA Astrophysics Data System (ADS)

    2007-08-01

    New Wide Field Near-Infrared Imager for ESO's Very Large Telescope Europe's flagship ground-based astronomical facility, the ESO VLT, has been equipped with a new 'eye' to study the Universe. Working in the near-infrared, the new instrument - dubbed HAWK-I - covers about 1/10th the area of the Full Moon in a single exposure. It is uniquely suited to the discovery and study of faint objects, such as distant galaxies or small stars and planets. ESO PR Photo 36a/07 ESO PR Photo 36a/07 HAWK-I on the VLT After three years of hard work, HAWK-I (High Acuity, Wide field K-band Imaging) saw First Light on Yepun, Unit Telescope number 4 of ESO's VLT, on the night of 31 July to 1 August 2007. The first images obtained impressively demonstrate its potential. "HAWK-I is a credit to the instrument team at ESO who designed, built and commissioned it," said Catherine Cesarsky, ESO's Director General. "No doubt, HAWK-I will allow rapid progress in very diverse areas of modern astronomy by filling a niche of wide-field, well-sampled near-infrared imagers on 8-m class telescopes." "It's wonderful; the instrument's performance has been terrific," declared Jeff Pirard, the HAWK-I Project Manager. "We could not have hoped for a better start, and look forward to scientifically exciting and beautiful images in the years to come." During this first commissioning period all instrument functions were checked, confirming that the instrument performance is at the level expected. Different astronomical objects were observed to test different characteristics of the instrument. For example, during one period of good atmospheric stability, images were taken towards the central bulge of our Galaxy. Many thousands of stars were visible over the field and allowed the astronomers to obtain stellar images only 3.4 pixels (0.34 arcsecond) wide, uniformly over the whole field of view, confirming the excellent optical quality of HAWK-I. ESO PR Photo 36b/07 ESO PR Photo 36c/07 Nebula in Serpens (HAWK-I

  19. How I Became an Astronomer

    NASA Technical Reports Server (NTRS)

    Maran, Stephen P.

    2001-01-01

    Life as an astronomer has taken me to view eclipses of the Sun from the Gaspe' Peninsula to the Pacific Ocean and the China and Coral Seas, and to observe the stars at observatories across the USA and as far south as Chile. I've also enjoyed working with NASA's telescopes in space, including the Hubble Space Telescope and the International Ultraviolet Explorer. It seems funny to reflect that it all began in the Sixth Grade by a fluke - the consequence of a hoax letter whose author I never identified.

  20. Models for Type I supernovae

    SciTech Connect

    Woosley, S.E.; Weaver, T.A.; Taam, R.E.

    1980-06-17

    Two rather disjoint scenarios for Type I supernovae are presented. One is based upon mass accretion by a white dwarf in a binary system. The second involves a star having some 8 to 10 times the mass of the sun which may or may not be a solitary star. Despite the apparent dissimilarities in the models it may be that each occurs to some extent in nature for they both share the possibility of producing substantial quantities of /sup 56/Ni and explosions in stars devoid of hydrogen envelopes. These are believed to be two properties that must be shared by any viable Type I model.

  1. H I SHELLS AND SUPERSHELLS IN THE I-GALFA H I 21 cm LINE SURVEY. I. FAST-EXPANDING H I SHELLS ASSOCIATED WITH SUPERNOVA REMNANTS

    SciTech Connect

    Park, G.; Koo, B.-C.; Gibson, S. J.; Newton, J. H.; Kang, J.-H.; Lane, D. C.; Douglas, K. A.; Peek, J. E. G.; Korpela, E. J.; Heiles, C.

    2013-11-01

    We search for fast-expanding H I shells associated with Galactic supernova remnants (SNRs) in the longitude range l ≈ 32° to 77° using 21 cm line data from the Inner-Galaxy Arecibo L-band Feed Array (I-GALFA) H I survey. Among the 39 known Galactic SNRs in this region, we find such H I shells in 4 SNRs: W44, G54.4-0.3, W51C, and CTB 80. All four were previously identified in low-resolution surveys, and three of those (excluding G54.4-0.3) were previously studied with the Arecibo telescope. A remarkable new result, however, is the detection of H I emission at both very high positive and negative velocities in W44 from the receding and approaching parts of the H I expanding shell, respectively. This is the first detection of both sides of an expanding shell associated with an SNR in H I 21 cm emission. The high-resolution I-GALFA survey data also reveal a prominent expanding H I shell with high circular symmetry associated with G54.4-0.3. We explore the physical characteristics of four SNRs and discuss what differentiates them from other SNRs in the survey area. We conclude that these four SNRs are likely the remnants of core-collapse supernovae interacting with a relatively dense (∼> 1 cm{sup –3}) ambient medium, and we discuss the visibility of SNRs in the H I 21 cm line.

  2. NHT-1 I/O Benchmarks

    NASA Technical Reports Server (NTRS)

    Carter, Russell; Ciotti, Bob; Fineberg, Sam; Nitzbert, Bill

    1992-01-01

    The NHT-1 benchmarks am a set of three scalable I/0 benchmarks suitable for evaluating the I/0 subsystems of high performance distributed memory computer systems. The benchmarks test application I/0, maximum sustained disk I/0, and maximum sustained network I/0. Sample codes are available which implement the benchmarks.

  3. The meganuclease I-SceI containing nuclear localization signal (NLS-I-SceI) efficiently mediated mammalian germline transgenesis via embryo cytoplasmic microinjection.

    PubMed

    Wang, Yong; Zhou, Xiao-Yang; Xiang, Peng-Ying; Wang, Lu-Lu; Tang, Huan; Xie, Fei; Li, Liang; Wei, Hong

    2014-01-01

    The meganuclease I-SceI has been effectively used to facilitate transgenesis in fish eggs for nearly a decade. I-SceI-mediated transgenesis is simply via embryo cytoplasmic microinjection and only involves plasmid vectors containing I-SceI recognition sequences, therefore regarding the transgenesis process and application of resulted transgenic organisms, I-SceI-mediated transgenesis is of minimal bio-safety concerns. However, currently no transgenic mammals derived from I-SceI-mediated transgenesis have been reported. In this work, we found that the native I-SceI molecule was not capable of facilitating transgenesis in mammalian embryos via cytoplasmic microinjection as it did in fish eggs. In contrast, the I-SceI molecule containing mammalian nuclear localization signal (NLS-I-SceI) was shown to be capable of transferring DNA fragments from cytoplasm into nuclear in porcine embryos, and cytoplasmic microinjection with NLS-I-SceI mRNA and circular I-SceI recognition sequence-containing transgene plasmids resulted in transgene expression in both mouse and porcine embryos. Besides, transfer of the cytoplasmically microinjected mouse and porcine embryos into synchronized recipient females both efficiently resulted in transgenic founders with germline transmission competence. These results provided a novel method to facilitate mammalian transgenesis using I-SceI, and using the NLS-I-SceI molecule, a simple, efficient and species-neutral transgenesis technology based on embryo cytoplasmic microinjection with minimal bio-safety concerns can be established for mammalian species. As far as we know, this is the first report for transgenic mammals derived from I-SceI-mediated transgenesis via embryo cytoplasmic microinjection.

  4. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  5. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  6. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  7. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  8. 30 CFR 57.22217 - Seals and stoppings (I-A, I-B, and I-C mines).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Seals and stoppings (I-A, I-B, and I-C mines... NONMETAL MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22217 Seals and stoppings (I-A, I-B, and I-C mines). All seals, and those stoppings that separate main intake from...

  9. Community Living Skills: Nutrition I.

    ERIC Educational Resources Information Center

    Kreps, Alice Roelofs; Dreith, Rita Vallero

    One of twenty course guides in the Community Living Skills Guide for the College for Living series, this document provides guidelines and workbook activities for the course, Nutrition I. The series of courses for developmentally disabled adults is intended to supplement residential programs and to aid in orienting institutionalized persons to…

  10. I'm like ... Professional

    ERIC Educational Resources Information Center

    Kyburz, Bonnie

    2010-01-01

    "Given that my film is exploring a punk ethos that attends DIY filmmaking, I decided that the rough nature of the video created appropriate content... these are the sorts of details that reveal the complex, cinema verite nature of the DIY experience."

  11. Putting the "I" in Science

    ERIC Educational Resources Information Center

    Goddard, Lise

    2014-01-01

    In this article, the author addresses the issue of bias in language used in conventional training in scientific writing that encourages adherence to the rule: "don't use 'I' when writing science reports." Such writing is to be objective rather than subjective; it is to be dispassionate, detached, fact-based, and…

  12. Tetraphenylphosphonium copper(I) dicyanamide.

    SciTech Connect

    Schlueter, J. A.; Geiser, U.; Materials Science Division

    2007-01-01

    In the title compound, {l_brace}(C{sub 24}H{sub 20}P)[Cu(C{sub 2}N{sub 3}){sub 2}]{r_brace}{sub n}, the copper(I) dicyanamide anion forms a distorted three-dimensional single diamondoid network. Templating tetraphenylphosphonium cations reside within the cavities of the polymeric anion.

  13. An iPad Education?

    ERIC Educational Resources Information Center

    Cooper, Kenneth J.

    2012-01-01

    In keeping with Steve Jobs' vision of transforming education, Apple has expanded its iTunes U so that professors can offer entire courses, not just lectures. So far, though, colleges and universities are not rushing to drop the platforms they use for online learning and adopt the new application from the technology heavyweight. Apple bills the…

  14. Being an iPadist

    ERIC Educational Resources Information Center

    Randles, Clint

    2013-01-01

    This column offers the personal reflections of the author on being a member of the band Touch, an iPad performing ensemble composed of music education faculty members and doctoral students at the University of South Florida. The ensemble primarily performed its own arrangements of popular music selections from a number of genres including, but not…

  15. Fire Officer I Lesson Plans.

    ERIC Educational Resources Information Center

    Pribyl, Paul F.

    Lesson plans are provided for the Fire Officer I course. Material for each lesson is presented in this format: course title, lesson title, equipment required, training aids needed, and a content outline which details teaching points and related instructor references. These references, or suggested readings, are listed at the conclusion of each…

  16. Wastewater Treatment I. Instructor's Manual.

    ERIC Educational Resources Information Center

    California Water Pollution Control Association, Sacramento. Joint Education Committee.

    This instructor's manual provides an outline and guide for teaching Wastewater Treatment I. It consists of nine sections. An introductory note and a course outline comprise sections 1 and 2. Section 3 (the bulk of the guide) presents lesson outlines for teaching the ten chapters of the manual entitled "Operation of Wastewater Treatment Plants."…

  17. Ares I Stage Separation Test

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, an Ares I x-test involves the upper stage separating from the first stage. This particular test was conducted at the NASA Langley Research Center in July 2007. (Highest resolution available)

  18. IPNS-I chopper spectrometers

    SciTech Connect

    Price, D.L.; Carpenter, J.M.; Pelizzari, C.A.; Sinha, S.K.; Bresof, I.; Ostrowski, G.E.

    1982-01-01

    We briefly describe the layout and operation of the two chopper experiments at IPNS-I. The recent measurement on solid /sup 4/He by Hilleke et al. provides examples of time-of-flight data from the Low Resolution Chopper Spectrometer.

  19. Teaching the iGeneration

    ERIC Educational Resources Information Center

    Rosen, Larry D.

    2011-01-01

    Children and teens today are immersed in technology. Just as we don't think about the existence of air, they don't think about technology and media. Individualized mobile devices have given them the expectation that if they conceive of something, they will be able to make it happen. Yet schools still expect these members of the iGeneration to…

  20. Panel I: Technology and Jobs.

    ERIC Educational Resources Information Center

    Appalachia, 1984

    1984-01-01

    Panel I features two case histories of state government, university, and private corporation cooperation to bring technology to the workplace (Microelectronics Center of North Carolina and Ben Franklin Partnership Program) and presentations about Burlington Industries and General Electric Company investments in technology to save jobs and boost…

  1. Title I and the Arts.

    ERIC Educational Resources Information Center

    Le Tendre, Mary Jean

    1997-01-01

    Argues that although improving academic achievement is the crux of Title I, the arts can contribute to enhancing academic achievement in at-risk students. An example of this approach is provided via partnership between the John F. Kennedy Center for the Performing Arts and Washington (DC) metropolitan school districts. (GR)

  2. Aerospace Environment. Aerospace Education I.

    ERIC Educational Resources Information Center

    Savler, D. S.; Smith, J. C.

    This book is one in the series on Aerospace Education I. It briefly reviews current knowledge of the universe, the earth and its life-supporting atmosphere, and the arrangement of celestial bodies in outer space and their physical characteristics. Chapter 1 includes a brief survey of the aerospace environment. Chapters 2 and 3 examine the…

  3. Quenched! The ISABELLE Saga, I

    NASA Astrophysics Data System (ADS)

    Crease, Robert P.

    2005-09-01

    The story of ISABELLE, a colliding-beam accelerator conceived in 1971, officially approved in 1978, partially constructed, and terminated in 1983, is an important episode in the history of post-World War II science in the United States.The events surrounding its planning, construction, and termination reveal much about the ambitions, strategies, and tensions of American high-energy physicists, their collaborations and rivalries, and the difficulties of funding and constructing a large scientific facility in the age of Big Science. In this article, the first of two parts, I cover the period up to the beginning of construction in 1978. I place ISABELLE in the context of the early history of colliders, outline the physics goals that motivated the machine, and describe the research and motivations behind its innovative but ultimately problematic superconducting magnet design. I cover the key technological and administrative steps that the laboratory took to get the project underway and steer it past several review committees. I also treat some of the conflicts within the laboratory, and between Brookhaven and other laboratories, especially Fermilab, that hampered the project.

  4. FIRE I - Extended Time Observations Data Sets

    Atmospheric Science Data Center

    2013-08-01

    FIRE I - Extended Time Observations Data Sets First ISCCP Regional Experiment (FIRE) I - Extended Time Observations were conducted in Utah. Relevant Documents:  FIRE Project Guide FIRE I - Extended Time Observations Home Page SCAR-B Block:  ...

  5. Saturn I Liquid-Oxygen (LOX) Tank

    NASA Technical Reports Server (NTRS)

    1960-01-01

    The Saturn I liquid-oxygen (LOX) tank for the Saturn I S-I stage being aligned with the end spider beam in the fabrication and engineering laboratory, building 4705, at the Marshall Space Flight Center (MSFC).

  6. Health Occupations Education I. Module No. I-A to I-G.

    ERIC Educational Resources Information Center

    Dunmeyer, Kathryn; And Others

    This set of 7 modules on medical and surgical asepsis is 1 of 11 sets in the Health Occupations Education I instructional package for the first year of a 2-year course of study. The materials are designed to prepare students through individualized instruction for entry-level job opportunities on health care teams in a variety of practice settings.…

  7. 40 CFR Table I-8 to Subpart I - Table I-8 to Subpart I of Part 98-Table I-8 to Subpart I of Part 98-Default Emission Factors (1...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Table I-8 to Subpart I of Part 98-Table I-8 to Subpart I of Part 98-Default Emission Factors (1-UN2O j) for N2O Utilization (UN2O j) I... Emission Factors (1-UN 2 O j) for N2O Utilization (UN2 O j) Process type factors N2O CVD 1-Ui 0.8...

  8. A Wolter type I LAMAR

    NASA Technical Reports Server (NTRS)

    Catura, R. C.; Joki, E. G.

    1981-01-01

    Observational objectives for the LAMAR and their influence on the instrument design are discussed. It is concluded that the most important design parameter is the angular resolution of the LAMAR modules since it so strongly influences sensitivity, optical identifications, source confusion, spectral resolution for objective gratings and the ability to resolve small extended sources. A high resolution Wolter Type I LAMAR module is described, its hardware status discussed, and the performance of a LAMAR observatory presented. A promising technique for enhancing the reflectivity of Wolter Type I X-ray optics in a selected bandpass at high energy has been investigated and the performance of the LAMAR module, utilizing this method, has been calculated.

  9. Studies of Nonlinear Problems. I

    DOE R&D Accomplishments Database

    Fermi, E.; Pasta, J.; Ulam, S.

    1955-05-01

    A one-dimensional dynamical system of 64 particles with forces between neighbors containing nonlinear terms has been studied on the Los Alamos computer MANIAC I. The nonlinear terms considered are quadratic, cubic, and broken linear types. The results are analyzed into Fourier components and plotted as a function of time. The results show very little, if any, tendency toward equipartition of energy among the degrees of freedom.

  10. Extragalatic zoo. I. [New galaxies

    SciTech Connect

    Schorn, R.A.

    1988-01-01

    The characteristics of various types of extragalactic objects are described. Consideration is given to cD galaxies, D galaxies, N galaxies, Markarian galaxies, liners, starburst galaxies, and megamasers. Emphasis is also placed on the isolated extragalatic H I region; the isolated extragalatic H II region; primeval galaxies or photogalaxies; peculiar galaxies; Arp galaxies; interacting galaxies; ring galaxies; and polar-ring galaxies. Diagrams of these objects are provided.

  11. Lunar Orbiter I - Moon & Earth

    NASA Technical Reports Server (NTRS)

    1966-01-01

    First view of the earth and moon from space. Published in: Spaceflight Revolution: Langley Research Center From Sputnik to Apollo, by James R. Hansen. NASA History Series. NASA SP ; 4308. p ii. Caption: 'The picture of the century was this first view of the earth from space. Lunar Orbiter I took the photo on 23 August 1966 on its 16th orbit just before it passed behind the moon. The photo also provided a spectacular dimensional view of the lunar surface.'

  12. Ares I Upper Stage Update

    NASA Technical Reports Server (NTRS)

    Davis, Daniel J.

    2010-01-01

    These presentation slides review the progress in the development of the Ares I upper stage. The development includes development of a manufacturing and processing assembly that will reduce the time required over 100 days, development of a weld tool that is a robotic tool that is the largest welder of its kind in the United States, development of avionics and software, and development of logisitics and operations systems.

  13. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel, that will fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  14. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image, depicts a manufactured aluminum panel, that will be used to fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  15. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts the manufacturing of aluminum panels that will be used to form the Ares I barrel. The panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  16. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel that will be used to fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California.

  17. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel that will be used to fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  18. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts confidence testing of a manufactured aluminum panel that will fabricate the Ares I upper stage barrel. In this test, bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  19. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured panel that will be used for the Ares I upper stage barrel fabrication. The aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  20. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts a manufactured aluminum panel, that will fabricate the Ares I upper stage barrel, undergoing a confidence panel test. In this test, the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  1. Optimizing Xenix I/O

    SciTech Connect

    Bottorff, P.; Potts, B.

    1983-08-01

    High performance microprocessors, inexpensive Winchester disk drives and low cost high density dynamic random access memories are making it feasible to incorporate minicomputer operating systems such as Unix into multiuser/multitasking microcomputers. However, before Unix and its derivatives can be efficiently integrated into a microcomputer environment, certain I/O and memory management hardware design problems previously limited to larger computer systems must be solved. These are discussed.

  2. STS-51I Mission Insignia

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The crew emblem for STS-51I is based on a strong patriotic theme with the basic colors of red, white, and blue suggesting the American flag and a dominant American bald eagle in aggressive flight. The 19 stars signify the numerical sequence of the flight. The shock wave represents that formed by the orbited during the entry phase of the flight. Surnames of crew members surround the top part of the circular design.

  3. 7 CFR 1006.51 - Class I differential, adjustments to Class I prices, and Class I price.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... MILK IN THE FLORIDA MARKETING AREA Order Regulating Handling Class Prices § 1006.51 Class I... 7 Agriculture 9 2012-01-01 2012-01-01 false Class I differential, adjustments to Class I prices, and Class I price. 1006.51 Section 1006.51 Agriculture Regulations of the Department of...

  4. Altus I aircraft on lakebed

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The remotely-piloted Altus I aircraft climbs away after takeoff from Rogers Dry Lake adjacent to NASA's Dryden Flight Research Center, Edwards, Calif. The short series of test flights sponsored by the Naval Postgraduate School in early August, 1997, were designed to demonstrate the ability of the experimental craft to cruise at altitudes above 40,000 feet for sustained durations. On its final flight Aug. 15, the Altus I reached an altitude of 43,500 feet. The Altus I and its sister ship, the Altus II, are variants of the Predator surveillance drone built by General Atomics/Aeronautical Systems, Inc. They are designed for high-altitude, long-duration scientific sampling missions, and are powered by turbocharged piston engines. The Altus I incorporates a single-stage turbocharger, while the Altus II, built for NASA's Environmental Research Aircraft and Sensor Technology program, sports a two-stage turbocharger to enable the craft to fly at altitudes above 55,000 feet. The Altus II, the first of the two craft to be completed, made its first flight on May 1, 1996. With its engine augmented by a single-stage turbocharger, the Altus II reached an altitude of 37,000 ft during its first series of development flights at Dryden in Aug., 1996. In Oct. of that year, the Altus II was flown in an Atmospheric Radiation Measurement study for the Department of Energy's Sandia National Laboratory in Oklahoma. During the course of those flights, the Altus II set a single-flight endurance record for remotely-operated aircraft of more than 26 hours. The Altus I, completed in 1997, flew a series of development flights at Dryden that summer. Those test flights culminated with the craft reaching an altitude of 43,500 ft while carrying a simulated 300-lb payload, a record for an unmanned aircraft powered by a piston engine augmented with a single-stage turbocharger. The Altus II sustained an altitudeof 55,000 feet for four hours in 1999. A pilot in a control station on the ground flies the

  5. Hereditary sensory neuropathy type I

    PubMed Central

    Auer-Grumbach, Michaela

    2008-01-01

    Hereditary sensory neuropathy type I (HSN I) is a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset. The exact prevalence is unknown, but is estimated as very low. Disease onset varies between the 2nd and 5th decade of life. The main clinical feature of HSN I is the reduction of sensation sense mainly distributed to the distal parts of the upper and lower limbs. Variable distal muscle weakness and wasting, and chronic skin ulcers are characteristic. Autonomic features (usually sweating disturbances) are invariably observed. Serious and common complications are spontaneous fractures, osteomyelitis and necrosis, as well as neuropathic arthropathy which may even necessitate amputations. Some patients suffer from severe pain attacks. Hypacusis or deafness, or cough and gastrooesophageal reflux have been observed in rare cases. HSN I is a genetically heterogenous condition with three loci and mutations in two genes (SPTLC1 and RAB7) identified so far. Diagnosis is based on the clinical observation and is supported by a family history. Nerve conduction studies confirm a sensory and motor neuropathy predominantly affecting the lower limbs. Radiological studies, including magnetic resonance imaging, are useful when bone infections or necrosis are suspected. Definitive diagnosis is based on the detection of mutations by direct sequencing of the SPTLC1 and RAB7 genes. Correct clinical assessment and genetic confirmation of the diagnosis are important for appropriate genetic counselling and prognosis. Differential diagnosis includes the other hereditary sensory and autonomic neuropathies (HSAN), especially HSAN II, as well as diabetic foot syndrome, alcoholic neuropathy, neuropathies caused by other neurotoxins/drugs, immune mediated neuropathy, amyloidosis, spinal cord diseases, tabes dorsalis, lepra neuropathy, or decaying skin

  6. Hereditary sensory neuropathy type I.

    PubMed

    Auer-Grumbach, Michaela

    2008-01-01

    Hereditary sensory neuropathy type I (HSN I) is a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset. The exact prevalence is unknown, but is estimated as very low. Disease onset varies between the 2nd and 5th decade of life. The main clinical feature of HSN I is the reduction of sensation sense mainly distributed to the distal parts of the upper and lower limbs. Variable distal muscle weakness and wasting, and chronic skin ulcers are characteristic. Autonomic features (usually sweating disturbances) are invariably observed. Serious and common complications are spontaneous fractures, osteomyelitis and necrosis, as well as neuropathic arthropathy which may even necessitate amputations. Some patients suffer from severe pain attacks. Hypacusis or deafness, or cough and gastrooesophageal reflux have been observed in rare cases. HSN I is a genetically heterogenous condition with three loci and mutations in two genes (SPTLC1 and RAB7) identified so far. Diagnosis is based on the clinical observation and is supported by a family history. Nerve conduction studies confirm a sensory and motor neuropathy predominantly affecting the lower limbs. Radiological studies, including magnetic resonance imaging, are useful when bone infections or necrosis are suspected. Definitive diagnosis is based on the detection of mutations by direct sequencing of the SPTLC1 and RAB7 genes. Correct clinical assessment and genetic confirmation of the diagnosis are important for appropriate genetic counselling and prognosis. Differential diagnosis includes the other hereditary sensory and autonomic neuropathies (HSAN), especially HSAN II, as well as diabetic foot syndrome, alcoholic neuropathy, neuropathies caused by other neurotoxins/drugs, immune mediated neuropathy, amyloidosis, spinal cord diseases, tabes dorsalis, lepra neuropathy, or decaying skin

  7. 31 CFR 359.6 - When may I redeem my Series I bond?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false When may I redeem my Series I bond... BONDS, SERIES I General Information § 359.6 When may I redeem my Series I bond? (a) Bonds issued on December 1, 2002, or earlier. You may redeem your Series I savings bond issued on January 1, 2003,...

  8. 31 CFR 359.6 - When may I redeem my Series I bond?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false When may I redeem my Series I bond... BONDS, SERIES I General Information § 359.6 When may I redeem my Series I bond? (a) Bonds issued on December 1, 2002, or earlier. You may redeem your Series I savings bond issued on January 1, 2003,...

  9. 78 FR 52232 - 2013 Temporary Closure of I-65 (I-70/I-65 South Split Interchange) in the City of Indianapolis

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... restricted area but, currently using I-65 and the local street system to reach their ultimate destinations... Federal Highway Administration 2013 Temporary Closure of I-65 (I-70/I-65 South Split Interchange) in the... close a 2-mile portion of I-65 in Indiana (from I-70/I-65 south split interchange to I-70/I-65...

  10. So I thought I wanted to be a chief.

    PubMed

    Sachs, Greg A

    2004-07-01

    In July 2000, Dr. William Hazzard published an article in the Journal of the American Geriatrics Society entitled "So you think you want to lead an academic geriatric program?" My answer to that question the same month was "Yes," as I agreed to become the chief of the newly established Section of Geriatrics at the University of Chicago. With about 3.5 years on the job now, I offer a more complete reply to Dr. Hazzard's query. Although his paper covered many important and practical issues to consider in looking at becoming a chief, this article provides a perspective on the academic geriatric leadership position based on a new chief's observations. Topics covered include pressures for and against becoming a chief, changing perspectives on goals and rewards, good help, mentoring, money problems/issues, support for the chief, and communication and relationships. It is hoped that these observations will be of use to geriatricians considering leading an academic geriatrics program and to other newly appointed chiefs. PMID:15209663

  11. <i>hhjj> production at the LHC

    SciTech Connect

    Dolan, Matthew J.; Englert, Christoph; Greiner, Nicolas; Nordstrom, Karl; Spannowsky, Michael

    2015-08-25

    The search for di-Higgs production at the LHC in order to set limits on the Higgs trilinear coupling and constraints on new physics is one of the main motivations for the LHC high-luminosity phase. Recent experimental analyses suggest that such analyses will only be successful if information from a range of channels is included. We therefore investigate di-Higgs production in association with two hadronic jets and give a detailed discussion of both the gluon- and the weak boson-fusion (WBF) contributions, with a particular emphasis on the phenomenology with modified Higgs trilinear and quartic gauge couplings. We perform a detailed investigation of the full hadronic final state and find that <i>hhjj> production should add sensitivity to a di-Higgs search combination at the HL-LHC with 3 ab-1. Since the WBF and GF contributions are sensitive to different sources of physics beyond the Standard Model, we devise search strategies to disentangle and isolate these production modes. In addition, while gluon fusion remains non-negligible in WBF-type selections, sizeable new physics contributions to the latter can still be constrained. As an example of the latter point we investigate the sensitivity that can be obtained for a measurement of the quartic Higgs–gauge boson couplings.

  12. Research Summary No. 36-3, Volume I, Part I. Volume I, Part One

    NASA Technical Reports Server (NTRS)

    1960-01-01

    The Research Summary is a bimonthly report of supporting research and development conducted at the Jet Propulsion Laboratory. This periodical is issued in three volumes. Volume I contains summaries of the work accomplished by the Space Sciences, Systems, Guidance and Control, and Telecommunications Divisions of the Laboratory. Volume II contains summaries of the work accomplished by the Physical Sciences, Engineering Mechanics, Engineering Facilities, and Propulsion Divisions. All work of a classified nature is contained in Volume Ill.

  13. 24 CFR 202.11 - Title I.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INSTITUTIONS AND MORTGAGEES Title I and Title II Specific Requirements § 202.11 Title I. (a) Types of... under the Title I program. The administrative actions that may be applied are set forth in 24 CFR part 25. Civil money penalties may be imposed against Title I lenders and mortgagees pursuant to 24...

  14. How Can I Live with Heart Failure?

    MedlinePlus

    ... me? Should I stay in bed? ©2015, American Heart Association Multi-language Fact Sheet Topics Heart-related Conditions What is Angina? What is an ... a Coronary Angiogram? How Can I Recover From Heart Surgery? What is Carotid ... Do I Understand "Nutrition Facts" Labels? How Can I Quit Smoking? How Can ...

  15. A Manual for Enforcing Title I Comparability.

    ERIC Educational Resources Information Center

    Lawyers' Committee for Civil Rights Under Law, Washington, DC.

    This manual is a detailed guide to the "comparability requirement" and other provisions of Title I of the Elementary and Secondary Education Act of 1965 which are intended to ensure that Title I programs provide compensatory education. Section I gives an overview of Title I and its comparability provision. Section II shows how to read and analyze…

  16. 24 CFR 202.11 - Title I.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... in 24 CFR 25.5. Civil money penalties may be imposed against Title I lenders and mortgagees pursuant... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title I. 202.11 Section 202.11... INSTITUTIONS AND MORTGAGEES Title I and Title II Specific Requirements § 202.11 Title I. (a)...

  17. {sup 129}I, {sup 131}I and {sup 127}I in animal thyroids after the Chernobyl nuclear accident

    SciTech Connect

    VanMiddleworth, L.; Handle, J.

    1997-10-01

    A small number of animal thyroids from Bad Hall, Austria; Ulm, Germany; and Steinkjer, Norway had {sup 131}I (half-life 8.06 d) measured between 21 and 72 d following the nuclear accident at Chernobyl on 26 April 1986. Nine years later {sup 129}I (half-life 1.57 x 10{sup 7} y) fission product and natural {sup 127}I were measured in the same thyroids. The mass ratios, {sup 129}I/{sup 131}I were calculated to the date of the Chernobyl accident and they ranged between 13 and 71. These ratios are compared to the expected ratios within an operating nuclear reactor during 2 y of operation, where the {sup 129}I/{sup 131}I{sup -1} ratio never exceeded 30. The observed ratio of {sup 129}I to natural {sup 127}I in thyroids ranged from 5 to 200 times the ratio before the accident, except that the Norwegian thyroids had {sup 129}I/{sup 127}I ratios which were less than the ratios of pre-Chernobyl thyroids from Ulm. These studies show the {sup 129}I and {sup 131}I from the Chernobyl accident were accumulated with natural {sup 127}I in animal thyroids but the isotope ratios, calculated to the release date, had wide ranges. The {sup 131}I radioactive exposure might be estimated from a fission product mixture by measuring {sup 129}I in thyroids long after the exposure to {sup 131}I, but the results would probably show a wide range of possibilities. The determining variables should be evaluated. We know of no previous data regarding both {sup 131}I and {sup 129}I in thyroid glands during the first 3 mo after the Chernobyl accident. 16 refs., 1 fig., 2 tabs.

  18. Structure of <i>Cryptosporidium> IMP dehydrogenase bound to an inhibitor with <i>in vivoi> antiparasitic activity

    SciTech Connect

    Kim, Youngchang; Makowska-Grzyska, Magdalena; Gorla, Suresh Kumar; Gollapalli, Deviprasad R.; Cuny, Gregory D.; Joachimiak, Andrzej; Hedstrom, Lizbeth

    2015-04-21

    Inosine 5´-monophosphate dehydrogenase (IMPDH) is a promising target for the treatment of <i>Cryptosporidium> infections. Here, the structure of <i>C. parvumi> IMPDH (<i>Cp>IMPDH) in complex with inosine 5´-monophosphate (IMP) and P131, an inhibitor with <i>in vivoi> anticryptosporidial activity, is reported. P131 contains two aromatic groups, one of which interacts with the hypoxanthine ring of IMP, while the second interacts with the aromatic ring of a tyrosine in the adjacent subunit. In addition, the amine and NO2 moieties bind in hydrated cavities, forming water-mediated hydrogen bonds to the protein. The design of compounds to replace these water molecules is a new strategy for the further optimization of <i>C. parvumi> inhibitors for both antiparasitic and antibacterial applications.

  19. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, processes for upper stage barrel fabrication are talking place. The aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  20. Ares I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, processes for upper stage barrel fabrication are talking place. The aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Highest resolution Available)

  1. ARES I Upper Stage Fabrication

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. In this HD video image, processes for upper stage barrel fabrication are talking place. Aluminum panels are manufacturing process demonstration articles that will undergo testing until perfected. The panels are built by AMRO Manufacturing located in El Monte, California. (Largest resolution available)

  2. Saturn I SA-2 Launch

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The second flight of the Saturn I vehicle, the SA-2, was successfully launched from Cape Canaveral, Florida on April 15, 1962. This vehicle had a secondary mission. After the first stage shutoff, at a 65-mile altitude, the water-filled upper stage was exploded, dumping 95 tons of water in the upper atmosphere. The resulting massive ice cloud rose to a height of 90 miles. The experiment, called Project Highwater, was intended to investigate the effects on the ionosphere of the sudden release of such a great volume of water.

  3. LeFort I Osteotomy

    PubMed Central

    Buchanan, Edward P.; Hyman, Charles H.

    2013-01-01

    The LeFort I osteotomy is one of the most commonly used procedures to correct midface deformities. It allows for correction in three dimensions including advancement, retrusion, elongation, and shortening. It is indicated, often in conjunction with mandibular surgery, for class II and III malocclusion, facial asymmetry, obstructive sleep apnea, and maxillary atrophy. Before surgery, proper orthodontics and surgical planning should be undertaken to ensure adequate outcomes. Overall, the surgery is widely used due to its low complication profile and reliable long-term results. PMID:24872761

  4. I'm Not Lisa.

    PubMed

    Brown, Kate

    2004-01-01

    Abstract "I'm Not Lisa," which evolved from the pain of the breakup of a nearly 15-year relationship, attempts to explore the fine line between love, intimacy, and insanity. Although in earlier drafts Lisa was dispatched in nasty (albeit quick and clean) fashion, the writing served as a catharsis of sorts, and the author decided that life and art is indeed more interesting with Lisa in it. As Lisa put it, "Kate, you can kill me asmany times as you need to, if that's what it takes."

  5. iDriving (Intelligent Driving)

    2012-09-17

    iDriving identifies the driving style factors that have a major impact on fuel economy. An optimization framework is used with the aim of optimizing a driving style with respect to these driving factors. A set of polynomial metamodels is constructed to reflect the responses produced in fuel economy by changing the driving factors. The optimization framework is used to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving stylesmore » in responses to actual driving conditions to improve fuel efficiency.« less

  6. Complete genome sequence of the Antarctic <i>Halorubrum lacusprofundii> type strain ACAM 34

    SciTech Connect

    Anderson, Iain J.; DasSarma, Priya; Lucas, Susan; Copeland, Alex; Lapidus, Alla; Del Rio, Tijana Glavina; Tice, Hope; Dalin, Eileen; Bruce, David C.; Goodwin, Lynne; Pitluck, Sam; Sims, David; Brettin, Thomas S.; Detter, John C.; Han, Cliff S.; Larimer, Frank; Hauser, Loren; Land, Miriam; Ivanova, Natalia; Richardson, Paul; Cavicchioli, Ricardo; DasSarma, Shiladitya; Woese, Carl R.; Kyrpides, Nikos C.

    2016-01-01

    <i>Halorubrum lacusprofundii> is an extreme halophile within the archaeal phylum <i>Euryarchaeota>. The type strain ACAM 34 was isolated from Deep Lake, Antarctica. <i>H. lacusprofundii> is of phylogenetic interest because it is distantly related to the haloarchaea that have previously been sequenced. It is also of interest because of its psychrotolerance. We report here the complete genome sequence of <i>H. lacusprofundii> type strain ACAM 34 and its annotation. In conclusion, this genome is part of a 2006 Joint Genome Institute Community Sequencing Program project to sequence genomes of diverse <i>Archaea>.

  7. <i>Decerns>: A framework for multi-criteria decision analysis

    SciTech Connect

    Yatsalo, Boris; Didenko, Vladimir; Gritsyuk, Sergey; Sullivan, Terry

    2015-02-27

    A new framework, <i>Decerns>, for multicriteria decision analysis (MCDA) of a wide range of practical problems on risk management is introduced. <i>Decerns> framework contains a library of modules that are the basis for two scalable systems: <i>DecernsMCDA> for analysis of multicriteria problems, and <i>DecernsSDSS> for multicriteria analysis of spatial options. <i>DecernsMCDA> includes well known MCDA methods and original methods for uncertainty treatment based on probabilistic approaches and fuzzy numbers. As a result, these MCDA methods are described along with a case study on analysis of multicriteria location problem.

  8. What I wish I had in my stockroom

    NASA Astrophysics Data System (ADS)

    Sampere, Samuel

    2015-12-01

    Most new teachers walk into their new classroom territory and find at least some equipment. Perhaps there are items there that you don't recognize. One way to get those types of questions answered is to post a question and/or picture on the TAP-L (Teaching Apparatus List) listserv (see: http://www.pira-online.org for more information). Within a few short minutes, the sender will receive at least a couple of responses. But what if a new teacher walks into a totally empty prep room? Now that teacher is tasked with purchasing useful equipment, and we know that the opportunity for a similar acquisition in the near future is slim. So you better choose wisely! Whether my new stockroom is well equipped or completely empty, I would make sure to have the following six items in my arsenal.

  9. iEMG: Imaging electromyography.

    PubMed

    Urbanek, Holger; van der Smagt, Patrick

    2016-04-01

    Advanced data analysis and visualization methodologies have played an important role in making surface electromyography both a valuable diagnostic methodology of neuromuscular disorders and a robust brain-machine interface, usable as a simple interface for prosthesis control, arm movement analysis, stiffness control, gait analysis, etc. But for diagnostic purposes, as well as for interfaces where the activation of single muscles is of interest, surface EMG suffers from severe crosstalk between deep and superficial muscle activation, making the reliable detection of the source of the signal, as well as reliable quantification of deeper muscle activation, prohibitively difficult. To address these issues we present a novel approach for processing surface electromyographic data. Our approach enables the reconstruction of 3D muscular activity location, making the depth of muscular activity directly visible. This is even possible when deep muscles are overlaid with superficial muscles, such as seen in the human forearm. The method, which we call imaging EMG (iEMG), is based on using the crosstalk between a sufficiently large number of surface electromyographic electrodes to reconstruct the 3D generating electrical potential distribution within a given area. Our results are validated by in vivo measurements of iEMG and ultrasound on the human forearm.

  10. Aquarius iPhone Application

    NASA Technical Reports Server (NTRS)

    Estes, Joseph C., Jr.; Arca. Jeremy M.; Ko, Michael A.; Oks, Boris

    2012-01-01

    The Office of the CIO at JPL has developed an iPhone application for the Aquarius/SAC-D mission. The application includes specific information about the science and purpose of the Aquarius satellite and also features daily mission news updates pulled from sources at Goddard Space Flight Center as well as Twitter. The application includes a media and data tab section. The media section displays images from the observatory, viewing construction up to the launch and also includes various videos and recorded diaries from the Aquarius Project Manager. The data tab highlights many of the factors that affect the Earth s ocean and the water cycle. The application leverages the iPhone s accelerometer to move the Aquarius Satellite over the Earth, revealing these factors. Lastly, this application features a countdown timer to the satellite s launch, which is currently counting the days since launch. This application was highly successful in promoting the Aquarius Mission and educating the public about how ocean salinity is paramount to understanding the Earth.

  11. [Friedrich Wilhelm I and porphyria].

    PubMed

    Pierach, C A; Jennewein, E

    1999-01-01

    Historical evidence has been collected attempting to diagnose members of royal houses, perhaps most publicized by Macalpine and Hunter (1969) for George III and his assumed porphyria, claiming that his insanity was a classic case of thereof. This rare metabolic disease presents with a variety of signs and symptoms: skin disease, abdominal pain, tachycardia, and neuro-psychiatric findings. The porphyrias are hereditary and since George III and Frederick William I share ancestors it seemed reasonable to investigate if the latter may also have suffered from porphyria. The pathography of both kings is meticulous, showing for both that abdominal pain, erratic behavior, restlessness, and discolored urine were frequently observed and complete recovery interictally was common. Intercurrent illnesses, fasting, alcohol and even tobacco smoking have been shown to be inducers of attacks and these risk factors are well documented in royal history.--The diagnosis of porphyria was not recognized then and other names were used, such as Cachexia hypochondriaca, Asthma spasmodico flatulentum, dolores arthritici.--We propose that Frederick William I suffered from an inducible porphyria.

  12. Stacking disorder in ice I.

    PubMed

    Malkin, Tamsin L; Murray, Benjamin J; Salzmann, Christoph G; Molinero, Valeria; Pickering, Steven J; Whale, Thomas F

    2015-01-01

    Traditionally, ice I was considered to exist in two well-defined crystalline forms at ambient pressure: stable hexagonal ice (ice Ih) and metastable cubic ice (ice Ic). However, it is becoming increasingly evident that what has been called cubic ice in the past does not have a structure consistent with the cubic crystal system. Instead, it is a stacking-disordered material containing cubic sequences interlaced with hexagonal sequences, which is termed stacking-disordered ice (ice Isd). In this article, we summarise previous work on ice with stacking disorder including ice that was called cubic ice in the past. We also present new experimental data which shows that ice which crystallises after heterogeneous nucleation in water droplets containing solid inclusions also contains stacking disorder even at freezing temperatures of around -15 °C. This supports the results from molecular simulations, that the structure of ice that crystallises initially from supercooled water is always stacking-disordered and that this metastable ice can transform to the stable hexagonal phase subject to the kinetics of recrystallization. We also show that stacking disorder in ice which forms from water droplets is quantitatively distinct from ice made via other routes. The emerging picture of ice I is that of a very complex material which frequently contains stacking disorder and this stacking disorder can vary in complexity depending on the route of formation and thermal history. PMID:25380218

  13. Standards in neurosonology. Part I.

    PubMed

    Wojczal, Joanna; Tomczyk, Tomasz; Luchowski, Piotr; Kozera, Grzegorz; Kaźmierski, Radosław; Stelmasiak, Zbigniew

    2015-09-01

    The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral arteries as well as a study of a specific brain structure, i.e. substantia nigra hyperechogenicity. The following aspects are included in the description of standards for each ultrasonographic method: equipment requirements, patient preparation, study technique and documentation as well as the required elements of ultrasound description. Practical criteria for the diagnosis of certain pathologies in accordance with the latest literature were also presented. Furthermore, additional comments were included in some of the sections. Part I discusses standards for the performance, documentation and description of different ultrasound methods (Duplex, Doppler). Part II and III are devoted to standards for specific clinical situations (vasospasm, monitoring after the acute stage of stroke, detection of a right-toleft shunts, confirmation of the arrest of the cerebral circulation, an assessment of the functional efficiency of circle of Willis, an assessment of the cerebrovascular vasomotor reserve as well as the measurement of substantia nigra hyperechogenicity).

  14. Essential Oils, Part I: Introduction.

    PubMed

    de Groot, Anton C; Schmidt, Erich

    2016-01-01

    Essential oils are widely used in the flavor, food, fragrance, and cosmetic industries in many applications. Contact allergy to them is well known and has been described for 80 essential oils. The relevance of positive patch test reactions often remains unknown. Knowledge of the chemical composition of essential oils among dermatologists is suspected to be limited, as such data are published in journals not read by the dermatological community. Therefore, the authors have fully reviewed and published the literature on contact allergy to and chemical composition of essential oils. Selected topics from this publication will be presented in abbreviated form in Dermatitis starting with this issue, including I. Introduction; II. General aspects; III. Chemistry; IV. General aspects of contact allergy; V. Peppermint oil, lavender oil and lemongrass oil; VI: Sandalwood oil, ylang-ylang oil, and jasmine absolute. PMID:26983089

  15. Ares I Static Tests Design

    NASA Technical Reports Server (NTRS)

    Carson, William; Lindemuth, Kathleen; Mich, John; White, K. Preston; Parker, Peter A.

    2009-01-01

    Probabilistic engineering design enhances safety and reduces costs by incorporating risk assessment directly into the design process. In this paper, we assess the format of the quantitative metrics for the vehicle which will replace the Space Shuttle, the Ares I rocket. Specifically, we address the metrics for in-flight measurement error in the vector position of the motor nozzle, dictated by limits on guidance, navigation, and control systems. Analyses include the propagation of error from measured to derived parameters, the time-series of dwell points for the duty cycle during static tests, and commanded versus achieved yaw angle during tests. Based on these analyses, we recommend a probabilistic template for specifying the maximum error in angular displacement and radial offset for the nozzle-position vector. Criteria for evaluating individual tests and risky decisions also are developed.

  16. High-quality permanent draft genome sequence of the <i>Parapiptadenia rigidai>-nodulating <i>Cupriavidus> sp. strain UYPR2.512

    SciTech Connect

    De Meyer, Sofie E.; Fabiano, Elena; Tian, Rui; Van Berkum, Peter; Seshadri, Rekha; Reddy, T. B. K.; Markowitz, Victor; Ivanova, Natalia N.; Pati, Amrita; Woyke, Tanja; Howieson, John; Kyrpides, Nikos C.; Reeve, Wayne

    2015-04-11

    <i>Cupriavidus> sp. strain UYPR2.512 is an aerobic, motile, Gram-negative, non-spore-forming rod that was isolated from a root nodule of <i>Parapiptadenia rigidai> grown in soils from a native forest of Uruguay. Here we describe the features of <i>Cupriavidus> sp. strain UYPR2.512, together with sequence and annotation. We find the 7,858,949 bp high-quality permanent draft genome is arranged in 365 scaffolds of 369 contigs, contains 7,411 protein-coding genes and 76 RNA-only encoding genes, and is part of the GEBA-RNB project proposal.

  17. Nanomechanics of Type I Collagen.

    PubMed

    Varma, Sameer; Orgel, Joseph P R O; Schieber, Jay D

    2016-07-12

    Type I collagen is the predominant collagen in mature tendons and ligaments, where it gives them their load-bearing mechanical properties. Fibrils of type I collagen are formed by the packing of polypeptide triple helices. Higher-order structures like fibril bundles and fibers are assembled from fibrils in the presence of other collagenous molecules and noncollagenous molecules. Curiously, however, experiments show that fibrils/fibril bundles are less resistant to axial stress compared to their constituent triple helices-the Young's moduli of fibrils/fibril bundles are an order-of-magnitude smaller than the Young's moduli of triple helices. Given the sensitivity of the Young's moduli of triple helices to solvation environment, a plausible explanation is that the packing of triple helices into fibrils perhaps reduces the Young's modulus of an individual triple helix, which results in fibrils having smaller Young's moduli. We find, however, from molecular dynamics and accelerated conformational sampling simulations that the Young's modulus of the buried core of the fibril is of the same order as that of a triple helix in aqueous phase. These simulations, therefore, suggest that the lower Young's moduli of fibrils/fibril bundles cannot be attributed to the specific packing of triple helices in the fibril core. It is not the fibril core that yields initially to axial stress. Rather, it must be the portion of the fibril exposed to the solvent and/or the fibril-fibril interface that bears the initial strain. Overall, this work provides estimates of Young's moduli and persistence lengths at two levels of collagen's structural assembly, which are necessary to quantitatively investigate the response of various biological factors on collagen mechanics, including congenital mutations, posttranslational modifications and ligand binding, and also engineer new collagen-based materials. PMID:27410733

  18. [Phase I cancer trials methodology].

    PubMed

    Le Tourneau, Christophe; Faivre, Sandrine; Raymond, Eric; Diéras, Véronique

    2007-11-01

    The main objective of phase I cancer trials is to determine precisely the recommended dose of an anticancer agent as a single agent or in a context of combinations of anticancer agents (including cytotoxic agents, immunotherapy, radiotherapy...), that is administered for the first time in man, to further proceed clinical development with phase II and III trials. The recommended dose must have the greatest efficiency with acceptable toxicity. For the anticancer agents, the ratio risk/benefit is high, since toxicities associated with many cancer therapeutic agents are substantial and because the efficacy is often limited. Thus, phase I cancer trials present unique challenges in comparison to other therapeutic areas. Indeed, it is essential to minimize the numbers of patients treated at subefficient dose levels, and in the same time not to expose the patients to unacceptable toxicity. Historically, the first method that has been used is the Fibonacci escalation. The major problems raised with this method have been the lengths of the trials and the risk to treat substantial numbers of patients at nontherapeutix doses. Thus, novel methods have been then developed modifying the numbers of patients included at each dose level and the rapidity of dose escalation. These methods include pharmacologically guided dose escalation, escalation with overdose control and the continual reassessment method which are both statistically based dose escalation methods, and the accelerated titration designs. Concerning the targeted anticancer therapies, the therapeutic effect on the target, due to their higher specificity, can be obtained using doses that have few toxicity. Using the toxicity to determine the recommended dose for phase II trials, as it is the case for "classical > anticancer agents, does not seem to be sufficient. Alternatives to determine the optimal biological dose include measurement of target inhibition, pharmacokinetic analysis and functional imaging.

  19. Observation of radioactive iodine ((131)I, (129)I) in cropland soil after the Fukushima nuclear accident.

    PubMed

    Fujiwara, Hideshi

    2016-10-01

    During the early stages of the Fukushima nuclear accident, the temporal variations of (131)I deposited on the ground and of (131)I accumulated in cropland soil were monitored at a fixed location in Japan. Moreover, concentrations of long-lived radioactive iodine ((129)I) in atmospheric deposits and soil were measured to examine the feasibility of retrospectively reconstructing (131)I levels from the levels of accident-derived (129)I. The exceptionally high levels of (131)I in deposits and soil were attributed to rainfall-related deposition of radionuclides. In the crop field studied, the losses of deposited (131)I and (129)I due to volatilization were small. The atomic ratio (129)I/(131)I in the topsoil corresponded to the same ratio in deposits. The (131)I concentrations measured in the topsoil were very consistent with the (131)I concentrations reconstructed from the (129)I concentrations in the soil. PMID:27320744

  20. Observation of radioactive iodine ((131)I, (129)I) in cropland soil after the Fukushima nuclear accident.

    PubMed

    Fujiwara, Hideshi

    2016-10-01

    During the early stages of the Fukushima nuclear accident, the temporal variations of (131)I deposited on the ground and of (131)I accumulated in cropland soil were monitored at a fixed location in Japan. Moreover, concentrations of long-lived radioactive iodine ((129)I) in atmospheric deposits and soil were measured to examine the feasibility of retrospectively reconstructing (131)I levels from the levels of accident-derived (129)I. The exceptionally high levels of (131)I in deposits and soil were attributed to rainfall-related deposition of radionuclides. In the crop field studied, the losses of deposited (131)I and (129)I due to volatilization were small. The atomic ratio (129)I/(131)I in the topsoil corresponded to the same ratio in deposits. The (131)I concentrations measured in the topsoil were very consistent with the (131)I concentrations reconstructed from the (129)I concentrations in the soil.

  1. Structure and proposed mechanism of α-glycerophosphate oxidase from <i>Mycoplasma pneumoniae>

    SciTech Connect

    Elkhal, Callia K.; Kean, Kelsey M.; Parsonage, Derek; Maenpuen, Somchart; Chaiyen, Pimchai; Claiborne, Al; Karplus, P. Andrew

    2015-03-14

    In this study, the formation of hydrogen peroxide (H₂O₂) by the FAD-dependent α-glycerophosphate oxidase (GlpO), is important for the pathogenesis of <i>Streptococcus pneumoniaei> and <i>Mycoplasma pneumoniaei>. The structurally known GlpO from <i>Streptococcus> sp. (<i>Ssp>GlpO) is similar to the pneumococcal protein (<i>Sp>GlpO) and provides a guide for drug design against that target. However, M. <i>pneumoniae> GlpO (<i>Mp>GlpO), having <20% sequence identity with structurally known GlpOs, appears to represent a second type of GlpO we designate as Type II GlpOs. Here, the recombinant His-tagged <i>Mp>GlpO structure is described at ~2.5 Å resolution, solved by molecular replacement using as a search model the <i>Bordetella pertussisi> protein 3253 (Bp3253) a protein of unknown function solved by structural genomics efforts. Recombinant <i>Mp>GlpO is an active oxidase with a turnover number of ~580 min⁻¹ while Bp3253 showed no GlpO activity. No substantial differences exist between the oxidized and dithionite-reduced <i>Mp>GlpO structures. Although, no liganded structures were determined, a comparison with the tartrate-bound Bp3253 structure and consideration of residue conservation patterns guided the construction of a model for α-glycerophosphate (Glp) recognition and turnover by <i>Mp>GlpO. The predicted binding mode also appears relevant for the type I GlpOs (such as <i>Ssp>GlpO) despite differences in substrate recognition residues, and it implicates a histidine conserved in type I and II Glp oxidases and dehydrogenases as the catalytic acid/base. This work provides a solid foundation for guiding further studies of the mitochondrial Glp dehydrogenases as well as for continued studies of <i>M. pneumoniaei> and <i>S. pneumoniaei> glycerol metabolism and the development of novel therapeutics targeting <i>Mp>GlpO and <i>Sp>GlpO.

  2. "I Hoped to Counteract the Memory Problem, but I Made No Impact Whatsoever": Discussing Methods in Computing Science Using "I"

    ERIC Educational Resources Information Center

    Harwood, Nigel

    2005-01-01

    This paper is a corpus-based study of how native speaker computing students and experts use the pronoun "I" when elaborating their methodology ("methodological I"). Using two corpora, (i) a student corpus of about 62,000 words of postgraduate computing project reports, written at the end of the MSc programme and roughly equivalent to the master's…

  3. Why Do I Need X-Rays?

    MedlinePlus

    ... to your desktop! more... Why Do I Need X-Rays? Article Chapters Why Do I Need X-Rays? ... of tooth decay. Updated: January 2012 Related Articles: X-Rays The Academy of General Dentistry (AGD) Sets the ...

  4. Can I prevent Pelvic Organ Prolapse

    MedlinePlus

    ... Pelvic Organ Prolapse POP Symptoms & Types Can I Prevent POP? POP Diagnosis POP Treatments 3 Resources + More Bladder Control UI Symptoms & Types Can I Prevent UI? UI Diagnosis UI Treatments 3 Resources + More ...

  5. HLA class I expression in bladder carcinomas.

    PubMed

    Cabrera, T; Pedrajas, G; Cozar, J M; Garrido, A; Vicente, J; Tallada, M; Garrido, F

    2003-10-01

    HLA class I molecules are frequently lost in a large variety of human carcinomas, possibly because of T-cell immune selection of major histocompatibility complex class I deficient tumor variants. We report that this phenomenon is also a frequent event in bladder carcinomas. Of a total of 72 bladder carcinomas, 72% of the tumors had at least one alteration in HLA class I expression. These altered HLA class I phenotypes were classified as total HLA class I loss (25%; phenotype I); HLA-A or/and HLA-B locus-specific loss (12%; phenotype III); and HLA class I allelic loss (35%; phenotype II or IV). Comparison of histopathological parameters with HLA class I expression showed a statistically significant relationship with the degree of differentiation and tumor recurrence.

  6. How do I remember that I know you know that I know?

    PubMed

    Rubin, Rachael D; Brown-Schmidt, Sarah; Duff, Melissa C; Tranel, Daniel; Cohen, Neal J

    2011-12-01

    Communication is aided greatly when speakers and listeners take advantage of mutually shared knowledge (i.e., common ground). How such information is represented in memory is not well known. Using a neuropsychological-psycholinguistic approach to real-time language understanding, we investigated the ability to form and use common ground during conversation in memory-impaired participants with hippocampal amnesia. Analyses of amnesics' eye fixations as they interpreted their partner's utterances about a set of objects demonstrated successful use of common ground when the amnesics had immediate access to common-ground information, but dramatic failures when they did not. These findings indicate a clear role for declarative memory in maintenance of common-ground representations. Even when amnesics were successful, however, the eye movement record revealed subtle deficits in resolving potential ambiguity among competing intended referents; this finding suggests that declarative memory may be critical to more basic aspects of the on-line resolution of linguistic ambiguity.

  7. Type I Interferons Direct Gammaherpesvirus Host Colonization

    PubMed Central

    Tan, Cindy S. E.; Lawler, Clara; May, Janet S.; Belz, Gabrielle T.; Stevenson, Philip G.

    2016-01-01

    Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. To understand how IFN-I and its evasion both control infection outcomes, we used Mx1-cre mice to tag floxed viral genomes in IFN-I responding cells. Epithelial-derived MuHV-4 showed low IFN-I exposure, and neither disrupting viral evasion nor blocking IFN-I signalling markedly affected acute viral replication in the lungs. Maximising IFN-I induction with poly(I:C) increased virus tagging in lung macrophages, but the tagged virus spread poorly. Lymphoid-derived MuHV-4 showed contrastingly high IFN-I exposure. This occurred mainly in B cells. IFN-I induction increased tagging without reducing viral loads; disrupting viral evasion caused marked attenuation; and blocking IFN-I signalling opened up new lytic spread between macrophages. Thus, the impact of IFN-I on viral replication was strongly cell type-dependent: epithelial infection induced little response; IFN-I largely suppressed macrophage infection; and viral evasion allowed passage through B cells despite IFN-I responses. As a result, IFN-I and its evasion promoted a switch in infection from acutely lytic in myeloid cells to chronically latent in B cells. Murine cytomegalovirus also showed a capacity to pass through IFN-I-responding cells, arguing that this is a core feature of herpesvirus host colonization. PMID:27223694

  8. Type I Interferons Direct Gammaherpesvirus Host Colonization.

    PubMed

    Tan, Cindy S E; Lawler, Clara; May, Janet S; Belz, Gabrielle T; Stevenson, Philip G

    2016-05-01

    Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. To understand how IFN-I and its evasion both control infection outcomes, we used Mx1-cre mice to tag floxed viral genomes in IFN-I responding cells. Epithelial-derived MuHV-4 showed low IFN-I exposure, and neither disrupting viral evasion nor blocking IFN-I signalling markedly affected acute viral replication in the lungs. Maximising IFN-I induction with poly(I:C) increased virus tagging in lung macrophages, but the tagged virus spread poorly. Lymphoid-derived MuHV-4 showed contrastingly high IFN-I exposure. This occurred mainly in B cells. IFN-I induction increased tagging without reducing viral loads; disrupting viral evasion caused marked attenuation; and blocking IFN-I signalling opened up new lytic spread between macrophages. Thus, the impact of IFN-I on viral replication was strongly cell type-dependent: epithelial infection induced little response; IFN-I largely suppressed macrophage infection; and viral evasion allowed passage through B cells despite IFN-I responses. As a result, IFN-I and its evasion promoted a switch in infection from acutely lytic in myeloid cells to chronically latent in B cells. Murine cytomegalovirus also showed a capacity to pass through IFN-I-responding cells, arguing that this is a core feature of herpesvirus host colonization. PMID:27223694

  9. Part I. Layered Double Hydroxides

    NASA Astrophysics Data System (ADS)

    Dimotakis, Emmanuel Dimitrios

    A new general method for the preparation of well -ordered layered double hydroxides (LDHs), (Mg_ {rm 1-x}Al_{ rm x} (OH)_2) (X^{rm n-}) _{rm n/x}{cdot}yH _2O, interlayered by organic anions has been developed. It is based on the reaction of meixnerite, (Mg_3Al(OH)_8) (OH) cdot2H_2O, with the free acid form of the desired anion--using glycerol as a swelling agent--to yield single crystalline products that are not readily available by conventional synthetic methods. The (Mg_3Al(OH) _8) -adipate and -p-toluenesulfonate derivatives undergo facile ion exchange reactions with Keggin-type (XM_{12}O_ {40}) ^{rm n -} or lacunary (XM_{11 }O_{39}) ^{rm m-} polyoxometalates (POMs) to form well-ordered, microporous pillared derivatives with the highest N_2 BET surface areas reported to date, namely 107 and 155 m^2 /g, respectively. Meixnerite, (Mg_3Al(OH) _8) (OH) cdot2H _2O, has unexpectedly been found to undergo similar ion exchange reactions, in a topotactic way, with retention of the structure of the intercalated POMs. The meixnerite was conveniently prepared for the first time from calcination of (Mg_3Al(OH) _8) (CO_3) _{0.5}{cdot}2H _2O and aqueous hydrolysis of the resulting NaCl-type solid solution. Metal carbonyl clusters have also been examined for ion-exchange (i.e., { (Pt _3(CO)_6) _{rm n}}^ {2-}) in these LDH-precursors. This chemistry is compared with the surface chemistry of (Mg_3 Al(OH)_8) (X^ {rm n-}) _{ rm 1/n}{cdot}2H _2O (X = CO_3^{2 -} or OH^{-}). It has been shown that the surface hydrolysis reaction: CO _3^{2-} + H _2O longrightarrow HCO_3^{-} + OH ^-, causes reductive condensation reactions of neutral carbonyl clusters with the LDH. The reactions were as efficient as with Na metal in solution. In part II of this work, Li-fluorohectorite, has been pillared with titanium polyoxocations derived from the acidic hydrolysis of TiCl_4 or Ti(i-OC_3H_7) _4. Raman spectroscopy of the product indicates that the pillars have a structure analogous to TiO_2(B) phase

  10. [The deconstructions of schizophrenia (I)].

    PubMed

    Moriyama, K

    1995-01-01

    Standing in the midst of this great historical change, as sometimes it is called the switch to the "post-modern", we are now confronted with the demand of paradigm change in every field of scientific knowledge. So it is the case with psychiatry. Just about 100 years ago, the trend of "social defense" (society's need to be protected from harm) was going on covering the whole civilized countries. It brought about a situation that could be generalized as "institutionalism" which made mental hospitals huge and custodial, resulting in the prevalence of nihilism with regard to treatment. It was just at this time that Dementia praecox, the preconcept of Schizophrenia, was formed by Kraepelin, E. (1896) as a mental disease resulting in peculiar dementia. After some period, Dementia praecox was transformed into Schizophrenia (Gruppe der Schizophrenien) by Bleuler, E. (1908) with a new methodology: to grasp the disease from the symptomatic viewpoint. Jaspers, K. (1912) as well as Schneider, K. (1938) followed him in the way that was psychopathologically more strict; the latter reached the formulation of the . Despite this eventful metamorphosis of the concept of Schizophrenia, its fundamental traits have remained unchanged until the late 1960's. They could be summarized as follows: 1) What patients mention is incomprehensible; 2) The prognosis leads to peculiar dementia; 3) The real cause of the disease is the brain disorder. These three are the reflection of the custodialism, curative nihilism and materialism through the institutionalized mental hospitals in those days. Now, since the 1970's, the situation has been completely changed, or at least, faced with inevitable changes. The tide of "deinstitutionalization" is covering all over the civilized countries, demanding the normalization of mentally disordered persons. Thus, deprived of its motherland (i.e. institutionalism), the concept of Schizophrenia has got into confusion or even crisis. And in

  11. I Think My Friend May Have an Eating Disorder. What Should I Do?

    MedlinePlus

    ... Cuts? I Think My Friend May Have an Eating Disorder. What Should I Do? KidsHealth > For Teens > I ... Signs of Eating Disorders How to Help About Eating Disorders Every year, thousands of teens (and adults, too) ...

  12. Draft genome sequence of <i>Raoultella terrigenai> R1Gly, a diazotrophic endophyte

    SciTech Connect

    Schicklberger, M.; Shapiro, N.; Loqué, D.; Woyke, T.; Chakraborty, R.

    2015-06-11

    <i>Raoultella terrigenai> R1Gly is a diazotrophic endophyte isolated from surface-sterilized roots of <i>Nicotiana tabacumi>. The whole-genome sequence was obtained to investigate the endophytic characteristics of this organism at the genetic level, as well as to compare this strain with its close relatives. To our knowledge, this is the first genome obtained from the <i>Raoultella terrigenai> species and only the third genome from the <i>Raoultella genusi>, after <i>Raoultella ornitholytici> and <i>Raoultella planticolai>. This genome will provide a foundation for further comparative genomic, metagenomic, and functional studies of this genus.

  13. Everything I know about business I learned from monopoly.

    PubMed

    Orbanes, Phil

    2002-03-01

    How do game designers approach their work? Perhaps in the same way that managers should. Here, the author, an expert in board-game design and the world's foremost authority on Monopoly, translates six tenets of game design into management principles. Three tenets focus on giving players the right level of structure. First, design simple and unambiguous rules: That also holds true in business; people engage most when responsibilities, objectives, and evaluation criteria are clear. Second, avoid frustrating the casual player. Just as not every game player aspires to be a grand master, not every employee wants to think like an executive. Third, establish a rhythm so that players know intuitively whether they are at the beginning, middle, or end of the game. Managers can also engineer such shifts of momentum and motivation for workers. Three more principles focus on providing entertainment. The most important is to tune into what's happening off the board. For many people, the real joy of a great game--or a great job--comes from the larger social experience surrounding it. Another key is to offer chances to come from behind. Even struggling employees want to believe, "The odds may be stacked against me, but just one great stroke and I'm right back in it." Finally, managers, like game designers, should provide outlets for latent talents. Games themselves can be useful in the workplace. For instance, an afternoon of game playing builds relationships and increases an organization's social capital. And simulation games can sharpen employees' business judgment. Managers may come to appreciate that games succeed depending on how well designed they are--and that many design challenges have their equivalents in the art of management.

  14. 19 CFR 12.104i - Enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Enforcement. 12.104i Section 12.104i Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY SPECIAL CLASSES OF MERCHANDISE Cultural Property § 12.104i Enforcement. In the customs territory of...

  15. I'll Never Do It Again

    ERIC Educational Resources Information Center

    Clift, Elayne

    2009-01-01

    While online teaching may be the wave of the future, it is not for this author, who writes "I trained for it, I tried it, and I'll never do it again." An instructor with years of experience successfully teaching in collegiate classrooms, she says online teaching does not compare. So she will chalk up her first and only venture to experience and…

  16. Parent Power and Title I ESEA.

    ERIC Educational Resources Information Center

    National Urban League, Inc., New York, NY.

    This pamphlet is designed to inform the parents of disadvantaged elementary and secondary school students of the provisions of ESEA Title I, and of the possible abuses of Title I funds which might otherwise be allocated to the direct improvement of their children's education. Its contents include: parents' guide to ESEA Title I: what it is and…

  17. Syntheses of Arnottin I and Arnottin II

    PubMed Central

    Moschitto, Matthew J.; Anthony, David R.; Lewis, Chad A.

    2015-01-01

    Short total syntheses of arnottin I and II were accomplished in 5 and 6 steps, respectively. A sesamol-benzyne cycloaddition with a 3-furyl-benzoate followed by regiospecific lactonization provided rapid, large-scale access to the core of arnottin I. Saponification of arnottin I and hypervalent iodide mediated spirocyclization provided an efficient and direct preparation of racemic arnottin II. PMID:25748275

  18. Title I, Higher Education Act Program Abstracts.

    ERIC Educational Resources Information Center

    Miller, Lorna M., Ed.

    The 1979 edition of the Title I, Higher Education Act Program Abstracts is presented. Directed toward state Title I, HEA administrators, the program abstracts are made available in order to encourage nationwide program replication of those tested and evaluated programs that have been conducted with Title I support by institutions of higher…

  19. Implementing RtI with Gifted Students

    ERIC Educational Resources Information Center

    Coleman, Mary Ruth, Ed.; Johnsen, Susan K., Ed.

    2012-01-01

    "Implementing RtI With Gifted Students" shares how RtI can fit within the framework of gifted education programming models. This edited book will serve as a reference guide for those interested in learning more about RtI and how it might be effectively implemented to meet the needs of all gifted students. Chapters contributed by top gifted…

  20. LIPIDS OF SARCINA LUTEA I.

    PubMed Central

    Huston, Charles K.; Albro, Phillip W.

    1964-01-01

    Huston, Charles K. (U.S. Army Biological Laboratories, Fort Detrick, Frederick, Md.), and Phillip W. Albro. Lipids of Sarcina lutea. I. Fatty acid composition of the extractable lipids. J. Bacteriol. 88:425–432. 1964.—The extractable lipids of Sarcina lutea were separated into several fractions by a combination of column and thin-layer chromatography. Qualitative and quantitative characterization of the fatty acid content of these lipid fractions was accomplished by means of gas-liquid chromatography and infrared analyses. Of the total extract, the lipids consisted of 2.1% free fatty acids, 51.0% glycerides, and 22.7% complex lipids; they had a fatty acid content with a complete spectrum of carbon numbers from C8 to C22. The fatty acids included a large component of branched-acids in addition to the normal straight-chain acids. The branched-acids, comprising 40% of the fatty acids analyzed, constituted a homologous series of iso-acids from C12 to C19. Two 18-carbon unsaturates were found cis-9-octadecenoate and cis-11-octadecenoate. A relatively high percentage (20.5%) of the extractable material from S. lutea was found to be hydrocarbon. This material was not further characterized. PMID:14203360

  1. Diurnal and seasonal variations of iodocarbons (CH2ClI, CH2I2, CH3I, and C2H5I) in the marine atmosphere

    NASA Astrophysics Data System (ADS)

    Yokouchi, Yoko; Saito, Takuya; Ooki, Atsushi; Mukai, Hitoshi

    2011-03-01

    Four iodocarbons, chloroiodomethane (CH2ClI), diiodomethane (CH2I2), methyl iodide (CH3I), and ethyl iodide (C2H5I), were measured with an automated preconcentration gas chromatography-mass spectrometry system at two remote marine sites, Hateruma Island (24.05°N, 123.8°E) in the East China Sea and Cape Ochiishi (43.15°N, 145.5°E) on the eastern coast of Hokkaido, for 17 months, giving the first full-year high-frequency data sets for all these compounds. CH2ClI and CH2I2, which are highly photolyzed, showed remarkable diurnal variation in all seasons, with lower concentrations in the daytime, whereas CH3I and C2H5I showed no significant diurnal changes. At Cape Ochiishi, all of the iodocarbons showed clear seasonal variations and were highest in summer and autumn, which are characterized by algal blooms in the adjacent ocean. At Hateruma Island, which is surrounded by subtropical oligotrophic waters, the seasonal variations were not significant, but C2H5I and CH2I2 showed lower mixing ratios in summer. The nighttime mixing ratio of CH2ClI was strongly and positively correlated with wind speed throughout the observation period at Hateruma Island, suggesting the ubiquitous presence of CH2ClI sources, probably nonbiogenic, in the subtropical ocean. CH3I and C2H5I mixing ratios occasionally increased at Hateruma Island concurrently with winter and spring pollution events from the Asian continent, indicating possible continental anthropogenic sources or emissions from seawater off the continental coast. A rise in the CH3I baseline mixing ratio was also observed at Hateruma Island, when the air mass origin became more southerly, compared with the earlier, easterly source area, suggesting higher concentrations in equatorial regions.

  2. SU-E-CAMPUS-I-03: Dosimetric Comparison of the Hypoxia Agent Iodoazomycin Arabinoside (IAZA) Labeled with the Radioisotopes I-123, I-131 and I-124

    SciTech Connect

    Jans, H-S; Stypinski, D; Mcquarrie, S; Kumar, P; Mercer, J; McEwan, S; Wiebe, L

    2014-06-15

    Purpose: To compare the radiation dose to normal organs from the radio-iodinated, hypoxia-binding radiosensitizer iodoazomycin arabinoside (IAZA) for three different isotopes of iodine. Methods: Dosimety studies with normal volunteers had been carried out with [{sup 123}I]IAZA, a drug binding selectively to hypoxic sites. Two other isotopes of iodine, {sup 131}I and {sup 124}I, offer the opportunity to use IAZA as an agent for radioisotope therapy and as an imaging tracer for Positron Emission Tomography. Radioisotope dosimetry for {sup 131}I and {sup 124}I was performed by first deriving from the [{sup 123}I]IAZA studies biological uptake and excretion data. The cumulated activities for {sup 131}I or {sup 124}I where obtained by including their half-lives when integrating the biological data and then extrapolating to infinite time points considering a) physical decay only or b) physical and biological excretion. Doses were calculated using the Medical Internal Radiation Dose (MIRD) schema (OLINDA1.1 code, Vanderbilt 2007). Results: Compared to {sup 123}I, organ doses were elevated on average by a factor 6 and 9 for {sup 131}I and {sup 124}I, respectively, if both physical decay and biological excretion were modeled. If only physical decay is considered, doses increase by a factor 18 ({sup 131}I) and 19 ({sup 124}I). Highest organ doses were observed in intestinal walls, urinary bladder and thyroid. Effective doses increased by a factor 11 and 14 for {sup 131}I and {sup 124}I, respectively, if biological and physical decay are present. Purely physical decay yields a 23-fold increase over {sup 123}I for both, {sup 131}I and {sup 124}I. Conclusion: Owing to the significant dose increase, caused by their longer half life and the approximately 10 times larger electronic dose deposited in tissue per nuclear decay, normal tissue doses of IAZA labeled with {sup 131}I and {sup 124}I need to be carefully considered when designing imaging and therapy protocols for clinical

  3. Nuclear magnetic moments of the ground states of sup 124 I, sup 126 I, and sup 130 I

    SciTech Connect

    Ohya, S.; Yamazaki, T.; Harasawa, T.; Katsurayama, M.; Mutsuro, N. ); Muto, S.; Heiguchi, K. )

    1992-01-01

    The nuclear magnetic moments of {sup 124}I, {sup 126}I, and {sup 130}I have been measured by the techniques of low-temperature nuclear orientation and nuclear magnetic resonance on oriented nuclei. The magnetic hyperfine splitting frequency {vert bar}{ital g}{mu}{sub {ital N}BHF}/{ital h}{vert bar} for {sup 124}I{ital Fe} was determined to be 630.2(2) MHz from a field-shift analysis of the measured resonances at the external field of 0.1, 0.2, 0.4, 0.6, and 0.8 T. The resonances for {sup 126}I{ital Fe} and {sup 130}I{ital Fe} were observed in an external magnetic field of 0.2 T at {nu}({sup 126}I{ital Fe})=627.7(2) MHz and {nu}({sup 130}I{ital Fe})=585.7(2) MHz, respectively. Using the recalculated hyperfine field of {ital B}{sub HF}({sup 131}I{ital Fe})=114.50(5) T, the magnetic moments were deduced: {vert bar}{mu}({sup 124}I,2{sup {minus}}){vert bar}=1.444(4){mu}{sub {ital N}}, {vert bar}{mu}({sup 126}I,2{sup {minus}}){vert bar}=1.436(5){mu}{sub {ital N}}, and {vert bar}{mu}({sup 130}I,5{sup +}){vert bar}=3.349(7){mu}{sub {ital N}}. The present value of the magnetic moment of {sup 124}I is very different from the value of 1.14(8){mu}{sub {ital N}} reported previously. The measured values of the magnetic moments are discussed using Lande formula.

  4. Scalable I/O Tracing and Analysis

    SciTech Connect

    Vijayakumar, Karthik; Mueller, Frank; Ma, Xiaosong; Roth, Philip C

    2009-01-01

    As supercomputer performance approached and then surpassed the petaflop level, I/O performance has become a major performance bottleneck for many scientific applications. Several tools exist to collect I/O traces to assist in the analysis of I/O performance problems. However, these tools either produce extremely large trace files that complicate performance analysis, or sacrifice accuracy to collect high-level statistical information. We propose a multi-level trace generator tool, ScalaIOTrace, that collects traces at several levels in the HPC I/O stack. ScalaIOTrace features aggressive trace compression that generates trace files of near constant size for regular I/O patterns and orders of magnitudes smaller for less regular ones. This enables the collection of I/O and communication traces of applications running on thousands of processors. Our contributions also include automated trace analysis to collect selected statistical information of I/O calls by parsing the compressed trace on-the-fly and time-accurate replay of communication events with MPI-IO calls. We evaluated our approach with the Parallel Ocean Program (POP) climate simulation and the FLASH parallel I/O benchmark. POP uses NetCDF as an I/O library while FLASH I/O uses the parallel HDF5 I/O library, which internally maps onto MPI-IO. We collected MPI-IO and low-level POSIX I/O traces to study application I/O behavior. Our results show constant size trace files of only 145KB irrespective of the number of nodes for FLASH I/O benchmark, which exhibits regular I/O and communication pattern. For POP, we observe up to two orders of magnitude reduction in trace file sizes compared to flat traces. Statistical information gathered reveals insight on the number of I/O and communication calls issued in the POP and FLASH I/O. Such concise traces are unprecedented for isolated I/O and combined I/O plus communication tracing.

  5. Improving microbial biogasoline production in <i>Escherichia colii> using tolerance engineering

    SciTech Connect

    Foo, Jee Loon; Jensen, Heather M.; Dahl, Robert H.; George, Kevin; Keasling, Jay D.; Lee, Taek Soon; Leong, Susanna; Mukhopadhyay, Aindrila

    2014-11-04

    Engineering microbial hosts for the production of fungible fuels requires mitigation of limitations posed on the production capacity. One such limitation arises from the inherent toxicity of solvent-like biofuel compounds to production strains, such as <i>Escherichia colii>. Here we show the importance of host engineering for the production of short-chain alcohols by studying the overexpression of genes upregulated in response to exogenous isopentenol. Using systems biology data, we selected 40 genes that were upregulated following isopentenol exposure and subsequently overexpressed them in <i>E. colii>. Overexpression of several of these candidates improved tolerance to exogenously added isopentenol. Genes conferring isopentenol tolerance phenotypes belonged to diverse functional groups, such as oxidative stress response (<i>soxS>, <i>fpr>, and <i>nrdH>), general stress response (<i>metR>, <i>yqhD>, and <i>gidB>), heat shock-related response (<i>ibpA>), and transport (<i>mdlB>). To determine if these genes could also improve isopentenol production, we coexpressed the tolerance-enhancing genes individually with an isopentenol production pathway. Our data show that expression of 6 of the 8 candidates improved the production of isopentenol in <i>E. colii>, with the methionine biosynthesis regulator MetR improving the titer for isopentenol production by 55%. Additionally, expression of MdlB, an ABC transporter, facilitated a 12% improvement in isopentenol production. To our knowledge, MdlB is the first example of a transporter that can be used to improve production of a short-chain alcohol and provides a valuable new avenue for host engineering in biogasoline production.

  6. Performance and breakdown characteristics of irradiated vertical power GaN <i>P-i-N> diodes

    SciTech Connect

    King, M. P.; Armstrong, A. M.; Dickerson, J. R.; Vizkelethy, G.; Fleming, R. M.; Campbell, J.; Wampler, W. R.; Kizilyalli, I. C.; Bour, D. P.; Aktas, O.; Nie, H.; Disney, D.; Wierer, Jr., J.; Allerman, A. A.; Moseley, M. W.; Kaplar, R. J.

    2015-10-29

    Electrical performance and defect characterization of vertical GaN <i>P-i-N> diodes before and after irradiation with 2.5 MeV protons and neutrons is investigated. Devices exhibit increase in specific on-resistance following irradiation with protons and neutrons, indicating displacement damage introduces defects into the p-GaN and n- drift regions of the device that impact on-state device performance. The breakdown voltage of these devices, initially above 1700 V, is observed to decrease only slightly for particle fluence <; 1013 cm-2. Furthermore, the unipolar figure of merit for power devices indicates that while the on-resistance and breakdown voltage degrade with irradiation, vertical GaN <i>P-i-Ns> remain superior to the performance of the best available, unirradiated silicon devices and on-par with unirradiated modern SiC-based power devices.

  7. Comet Schwassmann-Wachmann I

    NASA Technical Reports Server (NTRS)

    2003-01-01

    [figure removed for brevity, see original site]

    NASA's new Spitzer Space Telescope has captured an image of an unusual comet that experiences frequent outbursts, which produce abrupt changes in brightness. Periodic comet Schwassmann-Wachmann I (P/SW-1) has a nearly circular orbit just outside that of Jupiter, with an orbital period of 14.9 years. It is thought that the outbursts arise from the build-up of internal gas pressure as the heat of the Sun slowly evaporates frozen carbon dioxide and carbon monoxide beneath the blackened crust of the comet nucleus. When the internal pressure exceeds the strength of the overlying crust, a rupture occurs, and a burst of gas and dust fragments is ejected into space at speeds of 450 miles per hour (200 meters per second).

    This 24-micron image of P/SW-1 was obtained with the multiband imaging photometer for Spitzer. The image shows thermal infrared emission from the dusty coma and tail of the comet. The nucleus of the comet is about 18 miles (30 kilometers) in diameter and is too small to be resolved by Spitzer. The micron-sized dust grains in the coma and tail stream out away from the Sun. The dust and gas comprising the comet's nucleus is part of the same primordial materials from which the Sun and planets were formed billions of years ago. The complex carbon-rich molecules they contain may have provided some of the raw materials from which life originated on Earth.

    Schwassmann-Wachmann 1 is thought to be a member of a relatively new class of objects called 'Centaurs,' of which 45 objects are known. These are small icy bodies with orbits between those of Jupiter and Neptune. Astronomers believe that Centaurs are recent escapees from the Kuiper Belt, a zone of small bodies orbiting in a cloud at the distant reaches of the solar system.

    Two asteroids, 1996 GM36 (left) and 5238 Naozane (right) were serendipitously captured in the comet image. Because they are closer to us than the comet and have faster orbital

  8. 7 CFR 1005.51 - Class I differential, adjustments to Class I prices, and Class I price.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Class I differential, adjustments to Class I prices, and Class I price. 1005.51 Section 1005.51 Agriculture Regulations of the Department of Agriculture... GRAYSON 21085 0.20 KY GREEN 21087 0.20 KY HANCOCK 21091 0.10 KY HARDIN 21093 0.10 KY HARLAN 21095 0.50...

  9. 40 CFR 267.1108 - What must I do when I stop operating the containment building?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false What must I do when I stop operating the containment building? 267.1108 Section 267.1108 Protection of Environment ENVIRONMENTAL PROTECTION... FACILITIES OPERATING UNDER A STANDARDIZED PERMIT Containment buildings § 267.1108 What must I do when I...

  10. 40 CFR 267.1108 - What must I do when I stop operating the containment building?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false What must I do when I stop operating the containment building? 267.1108 Section 267.1108 Protection of Environment ENVIRONMENTAL PROTECTION... FACILITIES OPERATING UNDER A STANDARDIZED PERMIT Containment buildings § 267.1108 What must I do when I...

  11. 40 CFR 267.1106 - What do I do if I detect a release?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What do I do if I detect a release? 267.1106 Section 267.1106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1106 What do I do if I detect a release? Throughout the...

  12. 40 CFR 267.1108 - What must I do when I stop operating the containment building?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What must I do when I stop operating the containment building? 267.1108 Section 267.1108 Protection of Environment ENVIRONMENTAL PROTECTION... FACILITIES OPERATING UNDER A STANDARDIZED PERMIT Containment buildings § 267.1108 What must I do when I...

  13. 40 CFR 267.1106 - What do I do if I detect a release?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false What do I do if I detect a release? 267.1106 Section 267.1106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1106 What do I do if I detect a release? Throughout the...

  14. 40 CFR 267.1108 - What must I do when I stop operating the containment building?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false What must I do when I stop operating the containment building? 267.1108 Section 267.1108 Protection of Environment ENVIRONMENTAL PROTECTION... FACILITIES OPERATING UNDER A STANDARDIZED PERMIT Containment buildings § 267.1108 What must I do when I...

  15. 40 CFR 267.1106 - What do I do if I detect a release?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false What do I do if I detect a release? 267.1106 Section 267.1106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1106 What do I do if I detect a release? Throughout the...

  16. 40 CFR 267.1106 - What do I do if I detect a release?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What do I do if I detect a release? 267.1106 Section 267.1106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1106 What do I do if I detect a release? Throughout the...

  17. 30 CFR 250.1713 - Must I notify MMS before I begin well plugging operations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Must I notify MMS before I begin well plugging operations? 250.1713 Section 250.1713 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Activities Permanently Plugging Wells § 250.1713 Must I notify MMS before I begin well plugging...

  18. 40 CFR 267.201 - What must I do when I stop operating the tank system?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... with waste, and manage them as hazardous waste, unless 40 CFR 261.3(d) applies. The closure plan... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What must I do when I stop operating... OPERATING UNDER A STANDARDIZED PERMIT Tank Systems § 267.201 What must I do when I stop operating the...

  19. 40 CFR 267.201 - What must I do when I stop operating the tank system?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... with waste, and manage them as hazardous waste, unless 40 CFR 261.3(d) applies. The closure plan... 40 Protection of Environment 27 2014-07-01 2014-07-01 false What must I do when I stop operating... OPERATING UNDER A STANDARDIZED PERMIT Tank Systems § 267.201 What must I do when I stop operating the...

  20. 40 CFR 267.201 - What must I do when I stop operating the tank system?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... with waste, and manage them as hazardous waste, unless 40 CFR 261.3(d) applies. The closure plan... 40 Protection of Environment 28 2012-07-01 2012-07-01 false What must I do when I stop operating... OPERATING UNDER A STANDARDIZED PERMIT Tank Systems § 267.201 What must I do when I stop operating the...

  1. 40 CFR 267.201 - What must I do when I stop operating the tank system?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... with waste, and manage them as hazardous waste, unless 40 CFR 261.3(d) applies. The closure plan... 40 Protection of Environment 28 2013-07-01 2013-07-01 false What must I do when I stop operating... OPERATING UNDER A STANDARDIZED PERMIT Tank Systems § 267.201 What must I do when I stop operating the...

  2. 12 CFR 555.300 - Must I inform OTS before I use electronic means or facilities?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Must I inform OTS before I use electronic means... THE TREASURY ELECTRONIC OPERATIONS Requirements Applicable to All Savings Associations § 555.300 Must I inform OTS before I use electronic means or facilities? (a) General. A savings association...

  3. 30 CFR 280.11 - What must I do before I may conduct scientific research?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Apply for a Permit or File a Notice § 280.11 What must I do before I may conduct scientific research? You may conduct G&G scientific research activities related to hard minerals on the OCS only after you... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do before I may conduct...

  4. 30 CFR 585.1004 - What must I do before I request an Alternate Use RUE?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What must I do before I request an Alternate Use RUE? 585.1004 Section 585.1004 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Facilities Requesting An Alternate Use Rue § 585.1004 What must I do before I request an Alternate Use...

  5. 30 CFR 285.1004 - What must I do before I request an Alternate Use RUE?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do before I request an Alternate Use RUE? 285.1004 Section 285.1004 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Requesting An Alternate Use Rue § 285.1004 What must I do before I request an Alternate Use RUE? If you...

  6. 30 CFR 585.1004 - What must I do before I request an Alternate Use RUE?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What must I do before I request an Alternate Use RUE? 585.1004 Section 585.1004 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Facilities Requesting An Alternate Use Rue § 585.1004 What must I do before I request an Alternate Use...

  7. 30 CFR 585.1004 - What must I do before I request an Alternate Use RUE?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What must I do before I request an Alternate Use RUE? 585.1004 Section 585.1004 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... Facilities Requesting An Alternate Use Rue § 585.1004 What must I do before I request an Alternate Use...

  8. 25 CFR 26.33 - How do I show I need job training?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How do I show I need job training? 26.33 Section 26.33 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM Training Services § 26.33 How do I show I need job training? The need for Job Placement...

  9. 25 CFR 26.33 - How do I show I need job training?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How do I show I need job training? 26.33 Section 26.33 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM Training Services § 26.33 How do I show I need job training? The need for Job Placement...

  10. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Sulfur General § 203.75 What risk do I run if I request a redetermination? If you request...

  11. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Sulfur General § 203.75 What risk do I run if I request a redetermination? If you request...

  12. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT... Sulfur General § 203.75 What risk do I run if I request a redetermination? If you request...

  13. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... Expansion Projects § 203.75 What risk do I run if I request a redetermination? If you request...

  14. Expression of the <i>Acidothermus cellulolyticusi> E1 endoglucanase in <i>Caldicellulosiruptor besciii> enhances its ability to deconstruct crystalline cellulose

    SciTech Connect

    Chung, Daehwan; Young, Jenna; Cha, Minseok; Brunecky, Roman; Bomble, Yannick J.; Himmel, Michael E.; Westpheling, Janet

    2015-08-13

    The <i>Caldicellulosiruptor besciii> genome encodes a potent set of carbohydrate-active enzymes (CAZymes), found primarily as multi-domain enzymes that exhibit high cellulolytic and hemicellulolytic activity on and allow utilization of a broad range of substrates, including plant biomass without conventional pretreatment. CelA, the most abundant cellulase in the <i>C. besciii> secretome, uniquely combines a GH9 endoglucanase and a GH48 exoglucanase in one protein. The most effective commercial enzyme cocktails used in vitro to pretreat biomass are derived from fungal cellulases (cellobiohydrolases, endoglucanases and a β-d-glucosidases) that act synergistically to release sugars for microbial conversion. The <i>C. besciii> genome contains six GH5 domains in five different open reading frames. Four exist in multi-domain proteins and two as single catalytic domains. E1 is a GH5 endoglucanase reported to have high specific activity and simple architecture and is active at the growth temperature of <i>C. besciii>. E1 is an endo-1,4-β-glucanase linked to a family 2 carbohydrate-binding module shown to bind primarily to cellulosic substrates. As a result, we tested if the addition of this protein to the <i>C. besciii> secretome would improve its cellulolytic activity.

  15. Structural basis for suppression of hypernegative DNA supercoiling by <i>E. colii> topoisomerase I

    SciTech Connect

    Tan, Kemin; Zhou, Qingxuan; Cheng, Bokun; Zhang, Zhongtao; Joachimiak, Andrzej; Tse-Dinh, Yuk -Ching

    2015-10-20

    <i>Escherichia colii> topoisomerase I has an essential function in preventing hypernegative supercoiling of DNA. A full length structure of <i>E. colii> topoisomerase I reported here shows how the C-terminal domains bind single-stranded DNA (ssDNA) to recognize the accumulation of negative supercoils in duplex DNA. These C-terminal domains of <i>E. colii> topoisomerase I are known to interact with RNA polymerase, and two flexible linkers within the C-terminal domains may assist in the movement of the ssDNA for the rapid removal of transcription driven negative supercoils. The structure has also unveiled for the first time how the 4-Cys zinc ribbon domain and zinc ribbon-like domain bind ssDNA with primarily π -stacking interactions. Finally, this novel structure, in combination with new biochemical data, provides important insights into the mechanism of genome regulation by type IA topoisomerases that is essential for life, as well as the structures of homologous type IA TOP3α and TOP3β from higher eukaryotes that also have multiple 4-Cys zinc ribbon domains required for their physiological functions.

  16. Relationship between 129I and 127I contents in bovine thyroid glands from Argentina

    NASA Astrophysics Data System (ADS)

    Negri, A. E.; Fernández Niello, J. O.; Wallner, A.; Arazi, A.; Steier, P.

    2013-01-01

    129I/127I ratios and iodine concentrations in bovine thyroids stemming from Argentina were determined by accelerator mass spectrometry (AMS) and gas chromatography (GC), respectively. From these measurements, a relationship of the 129I/127I ratio with iodine content in the gland was obtained. A weak correlation between the two isotopes was found, suggesting that 129I re-emission from the ocean is not the only process for the 129I deposition in Argentina. Moreover, contributions to the total 129I inventory in the Southern hemisphere from both natural and anthropogenic sources were theoretically studied. Surface compartments present similar contribution from natural sources and nuclear explosions fallout.

  17. Characterization of novel sorghum <i>brown midribi> mutants from an EMS-mutagenized population

    SciTech Connect

    Sattler, Scott E.; Saballos, Ana; Xin, Zhanguo; Funnell-Harris, Deanna L.; Vermerris, Wilfred; Pedersen, Jeffrey F.

    2014-09-02

    Reducing lignin concentration in lignocellulosic biomass can increase forage digestibility for ruminant livestock and saccharification yields of biomass for bioenergy. In sorghum (<i>Sorghum bicolori> (L.) Moench) and several other C4 grasses, <i>brown midribi> (<i>bmr>) mutants have been shown to reduce lignin concentration. Putative <i>bmr> mutants isolated from an EMS-mutagenized population were characterized and classified based on their leaf midrib phenotype and allelism tests with the previously described sorghum <i>bmr> mutants <i>bmr2i>, <i>bmr6i>, and <i>bmr12i>. These tests resulted in the identification of additional alleles of <i>bmr2i>, <i>bmr6i>,and <i>bmr12i>, and, in addition, six <i>bmr> mutants were identified that were not allelic to these previously described loci. Further allelism testing among these six <i>bmr> mutants showed that they represented four novel <i>bmr> loci. Based on this study, the number of <i>bmr> loci uncovered in sorghum has doubled. The impact of these lines on agronomic traits and lignocellulosic composition was assessed in a 2-yr field study. Most of the identified <i>bmr> lines showed reduced lignin concentration of their biomass relative to wild-type (WT). Effects of the six new <i>bmr> mutants on enzymatic saccharification of lignocellulosic materials were determined, but the amount of glucose released from the stover was similar to WT in all cases. Like <i>bmr2i>, <i>bmr6i>, and <i>bmr12i>, these mutants may affect monolignol biosynthesis and may be useful for bioenergy and forage improvement when stacked together or in combination with the three previously described <i>bmr> alleles.

  18. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  19. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  20. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  1. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  2. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  3. Under-detection of endospore-forming <i>Firmicutes> in metagenomic data

    SciTech Connect

    Filippidou, Sevasti; Junier, Thomas; Wunderlin, Tina; Lo, Chien -Chi; Li, Po -E; Chain, Patrick S.; Junier, Pilar

    2015-04-25

    Microbial diversity studies based on metagenomic sequencing have greatly enhanced our knowledge of the microbial world. However, one caveat is the fact that not all microorganisms are equally well detected, questioning the universality of this approach. <i>Firmicutes> are known to be a dominant bacterial group. Several <i>Firmicutes> species are endospore formers and this property makes them hardy in potentially harsh conditions, and thus likely to be present in a wide variety of environments, even as residents and not functional players. While metagenomic libraries can be expected to contain endospore formers, endospores are known to be resilient to many traditional methods of DNA isolation and thus potentially undetectable. In this study we evaluated the representation of endospore-forming <i>Firmicutes> in 73 published metagenomic datasets using two molecular markers unique to this bacterial group (<i>spo0Ai> and <i>gpr>). Both markers were notably absent in well-known habitats of <i>Firmicutes> such as soil, with <i>spo0Ai> found only in three mammalian gut microbiomes. A tailored DNA extraction method resulted in the detection of a large diversity of endospore-formers in amplicon sequencing of the 16S rRNA and <i>spo0Ai> genes. However, shotgun classification was still poor with only a minor fraction of the community assigned to <i>Firmicutes>. Thus, removing a specific bias in a molecular workflow improves detection in amplicon sequencing, but it was insufficient to overcome the limitations for detecting endospore-forming <i>Firmicutes> in whole-genome metagenomics. In conclusion, this study highlights the importance of understanding the specific methodological biases that can contribute to improve the universality of metagenomic approaches.

  4. Silver iodide sodalite for 129I immobilisation

    NASA Astrophysics Data System (ADS)

    Vance, E. R.; Gregg, D. J.; Grant, C.; Stopic, A.; Maddrell, E. R.

    2016-11-01

    Silver iodide sodalite was initially synthesised as a fine-grained major phase in a nominally stoichiometric composition following hot isostatic pressing at 850 °C with 100 MPa and its composition, Ag4Al3Si3O12I, was approximately verified by scanning electron microscopy. An alternative preparative method yielded a more dense and stoichiometric AgI sodalite on sintering and HIPing. As found for AgI, the I is released from AgI sodalite much more readily in reducing water than in ordinary water. Thus in normal PCT-B tests, the I release was <0.3 g/L in water, but it was ∼70 g/L under highly reducing conditions. This is an important point with regard to can material if HIPing is used for consolidation.

  5. I2Cnet medical image annotation service.

    PubMed

    Chronaki, C E; Zabulis, X; Orphanoudakis, S C

    1997-01-01

    I2Cnet (Image Indexing by Content network) aims to provide services related to the content-based management of images in healthcare over the World-Wide Web. Each I2Cnet server maintains an autonomous repository of medical images and related information. The annotation service of I2Cnet allows specialists to interact with the contents of the repository, adding comments or illustrations to medical images of interest. I2Cnet annotations may be communicated to other users via e-mail or posted to I2Cnet for inclusion in its local repositories. This paper discusses the annotation service of I2Cnet and argues that such services pave the way towards the evolution of active digital medical image libraries.

  6. Adiabatic invariance of oscillons/I -balls

    NASA Astrophysics Data System (ADS)

    Kawasaki, Masahiro; Takahashi, Fuminobu; Takeda, Naoyuki

    2015-11-01

    Real scalar fields are known to fragment into spatially localized and long-lived solitons called oscillons or I -balls. We prove the adiabatic invariance of the oscillons/I -balls for a potential that allows periodic motion even in the presence of non-negligible spatial gradient energy. We show that such a potential is uniquely determined to be the quadratic one with a logarithmic correction, for which the oscillons/I -balls are absolutely stable. For slightly different forms of the scalar potential dominated by the quadratic one, the oscillons/I -balls are only quasistable, because the adiabatic charge is only approximately conserved. We check the conservation of the adiabatic charge of the I -balls in numerical simulation by slowly varying the coefficient of logarithmic corrections. This unambiguously shows that the longevity of oscillons/I -balls is due to the adiabatic invariance.

  7. Lithium in population I subgiants

    NASA Astrophysics Data System (ADS)

    Randich, S.; Gratton, R.; Pallavicini, R.; Pasquini, L.; Carretta, E.

    1999-08-01

    We present a lithium survey for a sample of 91 Pop. I stars. JHKL photometry was also obtained for 61 stars in the sample. Besides Li abundances, [Fe/H] values were derived. Thanks to Hipparcos parallaxes, we could infer absolute V magnitudes for our sample stars and were able to place them on the color-magnitude diagram, which allowed us to constrain their evolutionary status. Masses and ages were derived for most of the stars by comparison with evolutionary tracks. The sample was originally selected so to include class IV stars later than spectral-type F0, but, based on the location on the color-magnitude diagram, we found a posteriori that a fraction of the stars (about 20%) are either main sequence stars or evolved giants. As it is the case for dwarfs and giants, a large spread in lithium abundance is present among the subgiants in our sample. As expected, the average lithium decreases as the stars evolve along the subgiant branch; however, there is not a one-to-one relationship between the position on the color-magnitude diagram and lithium abundance, and the observed dispersion is only partially explainable as due to a dispersion in mass, metallicity, and age. In particular, a dispersion in lithium is seen among slightly evolved subgiants with masses close to solar but in the same evolutionary stage as the G2 IV star beta Hyi. The comparison of the beta Hyi-like sample with a sample of non evolved solar-like stars indeed suggests that beta Hyi has most likely evolved from a main sequence Li-rich star, rather than from a Li-poor star (like the Sun) that has dredged-up previously stored lithium. Our sample includes several stars that have completed the first-dredge up lithium dilution, but that have not yet evolved to the evolutionary point where extra-mixing in the giant phase is thought to occur. A large number of them have Li abundances considerably below the theoretical predictions of first dredge-up dilution. We confirm that this is due to the fact that

  8. CBP PHASE I CODE INTEGRATION

    SciTech Connect

    Smith, F.; Brown, K.; Flach, G.; Sarkar, S.

    2011-09-30

    The goal of the Cementitious Barriers Partnership (CBP) is to develop a reasonable and credible set of software tools to predict the structural, hydraulic, and chemical performance of cement barriers used in nuclear applications over extended time frames (greater than 100 years for operating facilities and greater than 1000 years for waste management). The simulation tools will be used to evaluate and predict the behavior of cementitious barriers used in near surface engineered waste disposal systems including waste forms, containment structures, entombments, and environmental remediation. These cementitious materials are exposed to dynamic environmental conditions that cause changes in material properties via (i) aging, (ii) chloride attack, (iii) sulfate attack, (iv) carbonation, (v) oxidation, and (vi) primary constituent leaching. A set of state-of-the-art software tools has been selected as a starting point to capture these important aging and degradation phenomena. Integration of existing software developed by the CBP partner organizations was determined to be the quickest method of meeting the CBP goal of providing a computational tool that improves the prediction of the long-term behavior of cementitious materials. These partner codes were selected based on their maturity and ability to address the problems outlined above. The GoldSim Monte Carlo simulation program (GTG 2010a, GTG 2010b) was chosen as the code integration platform (Brown & Flach 2009b). GoldSim (current Version 10.5) is a Windows based graphical object-oriented computer program that provides a flexible environment for model development (Brown & Flach 2009b). The linking of GoldSim to external codes has previously been successfully demonstrated (Eary 2007, Mattie et al. 2007). GoldSim is capable of performing deterministic and probabilistic simulations and of modeling radioactive decay and constituent transport. As part of the CBP project, a general Dynamic Link Library (DLL) interface was

  9. Investigations of the F conjugation gene traI:traI mutants and lambdatraI transducing phages.

    PubMed

    Willetts, N; Maule, J

    1979-02-01

    A series of traI point and deletion mutants of Flac, and a traM mutant, were characterised. Complementation tests with an amber Flac traI mutant confirmed their genotypes, and in addition all the traI mutants, but not the traM mutant, were complemented by pRS31 (PSC101 traDI) and EDlambda109 (lambdatraI). Judging from the efficiencies of plating of F-specific phages, none of the mutations affected pilus formation. The traI products of F and of the F-like plasmid R1 were interchangeable with each other but not with that of R100, while the traM product of F could not be replaced by those of R1 or of R100. Neither traI nor traM were needed for conjugal transfer of ColE1. Three lambda transducing phages carrying traI were isolated by in vivo or in vitro techniques, and characterised by genetic complementation tests, by analysis of the fragments produced by restriction endonucleases, and by measurement of heteroduplex molecules. The genetic structures together with the sizes and F coordinates, of the transfer regions carried by the phages were thereby determined. Comparison of the proteins synthesised in UV-irradiated cells by one of the lambdatraI phages with those made by a derivative carrying an amber traI mutation, allowed the traI product to be identified as a protein of molecular weight 174,000. In addition, the molecular weights of the traD (84,000), traS (18,000), and traT (25,000) products made by the lambdatraSTD1 phage EDlambda107 were measured. The possible roles of the traI and traM products in conjugation are discussed. PMID:372754

  10. The thermodynamic characteristics of vaporization in the NaI-PrI3 system

    NASA Astrophysics Data System (ADS)

    Motalov, V. B.; Kudin, L. S.; Markus, T.

    2009-05-01

    The vaporization of the NaI-PrI3 quasi-binary system was studied by high-temperature mass spectrometry over the whole concentration range. At 623-994 K, saturated vapor contained not only (NaI) n and (PrI3) n molecules ( n = 1, 2) and Na+(NaI) n ( n = 0-4) and I-(PrI3) n ( n = 1-2) ions but also mixed molecular and ionic associates recorded for the first time (NaPrI4, Na2PrI5, NaPrI{3/+}, Na2PrI{4/+}, Na3PrI{5/+}, Na4PrI{6/+}, NaPrI{5/-}, and NaPr2I{8/-}). The partial vapor pressures of molecules were calculated, and the equilibrium constants of the dissociation of neutral and charged associates were measured. The enthalpies of molecular and ion-molecular reactions were determined, and the enthalpies of formation of gaseous molecules and ions were obtained.

  11. Leading a successful iGEM team.

    PubMed

    Materi, Wayne

    2012-01-01

    The International Genetically Engineered Machines (iGEM) competition allows undergraduate teams to develop projects in synthetic biology within the context of a large, international Jamboree. Organizing and managing a successful iGEM team is an exercise in advanced agile project development. While many of the principles applicable to such teams are derived from management of agile software teams, iGEM presents several unique challenges. PMID:22328439

  12. New organically templated photoluminescence iodocuprates(I)

    SciTech Connect

    Hou Qin; Zhao Jinjing; Zhao Tianqi; Jin Juan; Yu Jiehui; Xu Jiqing

    2011-07-15

    Two types of organic cyclic aliphatic diamine molecules piperazine (pip) and 1,3-bis(4-piperidyl)propane (bpp) were used, respectively, to react with an inorganic mixture of CuI and KI in the acidic CH{sub 3}OH solutions under the solvothermal conditions, generating finally three new organically templated iodocuprates as 2-D layered [(Hpip)Cu{sub 3}I{sub 4}] 1, 1-D chained [tmpip][Cu{sub 2}I{sub 4}] 2 (tmpip=N,N,N',N'-tetramethylpiperazinium) and dinuclear [H{sub 2}bpp]{sub 2}[Cu{sub 2}I{sub 5}] I.2H{sub 2}O 3. Note that the templating agent tmpip{sup 2+} in compound 2 originated from the in situ N-alkylation reaction between the pip molecule and the methanol solvent. The photoluminescence analysis indicates that the title compounds emit the different lights: yellow for 1, blue for 2 and yellow-green for 3, respectively. - Graphical abstract: The solvothermal self-assemblies of CuI, KI and pip/bpp in acidic CH{sub 3}OH solutions created three iodocuprates 2-D layered [(Hpip)Cu{sub 3}I{sub 4}] 1, 1-D chained [tmpip][Cu{sub 2}I{sub 4}] 2 and dinuclear [H{sub 2}bpp]{sub 2}[Cu{sub 2}I{sub 5}] I.2H{sub 2}O 3. Highlights: > A new layered iodocuprate(I) with 20-membered rings was hydrothermally prepared. > A simple approach to prepare the new organic templating agent was reported. > Photoluminescence analysis indicates the emission for iodocuprate(I) is associated with the Cu...Cu interactions.

  13. Leading a successful iGEM team.

    PubMed

    Materi, Wayne

    2012-01-01

    The International Genetically Engineered Machines (iGEM) competition allows undergraduate teams to develop projects in synthetic biology within the context of a large, international Jamboree. Organizing and managing a successful iGEM team is an exercise in advanced agile project development. While many of the principles applicable to such teams are derived from management of agile software teams, iGEM presents several unique challenges.

  14. Clinical Outcome Measures in Chiari I Malformation.

    PubMed

    Yarbrough, Chester K; Greenberg, Jacob K; Park, Tae Sung

    2015-10-01

    Chiari malformation type 1 (CM-I) is a common and often debilitating neurologic disease. Reliable evaluation of treatments has been hampered by inconsistent use of clinical outcome measures. A variety of outcome measurement tools are available, although few have been validated in CM-I. The recent development of the Chicago Chiari Outcome Scale and the Chiari Symptom Profile provides CM-I-specific instruments to measure outcomes in adults and children, although validation and refinement may be necessary.

  15. Rare case of orofaciodigital syndrome type I

    PubMed Central

    Singh, Abhishek Bahadur; Girhotra, Manish; Goel, Medha; Bhatia, Shilpee

    2013-01-01

    Orofaciodigital syndrome (OFDS) is a group of congenital anomalies which affects the face, oral structures and digits. There are nine subtypes with different modes of inheritance. OFDS type I is an X-linked dominant trait with lethality in the vast majority of affected males. We report a case of OFDS type I in an Indian girl at the age of seven who had most of the typical features of OFDS type I and nephrocalcinosis. PMID:23417374

  16. Experimental Breeder Reactor I Preservation Plan

    SciTech Connect

    Julie Braun

    2006-10-01

    Experimental Breeder Reactor I (EBR I) is a National Historic Landmark located at the Idaho National Laboratory, a Department of Energy laboratory in southeastern Idaho. The facility is significant for its association and contributions to the development of nuclear reactor testing and development. This Plan includes a structural assessment of the interior and exterior of the EBR I Reactor Building from a preservation, rather than an engineering stand point and recommendations for maintenance to ensure its continued protection.

  17. Electronic structure, transport, and phonons of SrAg<i>Ch>F (<i>Ch> = S,Se,Te): Bulk superlattice thermoelectrics

    SciTech Connect

    Gudelli, Vijay Kumar; Kanchana, V.; Vaitheeswaran, G.; Singh, David J.; Svane, Axel; Christensen, Niels Egede; Mahanti, Subhendra D.

    2015-07-15

    Here, we report calculations of the electronic structure, vibrational properties, and transport for the p-type semiconductors, SrAg<i>Ch>F (<i>Ch> = S, Se, and Te). We find soft phonons with low frequency optical branches intersecting the acoustic modes below 50 cm–1, indicative of a material with low thermal conductivity. The bands at and near the valence-band maxima are highly two-dimensional, which leads to high thermopowers even at high carrier concentrations, which is a combination that suggests good thermoelectric performance. These materials may be regarded as bulk realizations of superlattice thermoelectrics.

  18. Mod I automotive Stirling engine mechanical development

    SciTech Connect

    Simetkosky, M.

    1984-01-01

    The Mod I Stirling engine was the first automotive Stirling engine designed specifically for automotive application. Testing of these engines has revealed several deficiencies in engine mechanical integrity which have been corrected by redesign or upgrade. The main deficiencies uncovered during the Mod I program lie in the combustion, auxiliary, main seal, and heater head areas. This paper will address each of the major area deficiencies in detail, and describe the corrective actions taken as they apply to the Mod I and the next Stirling-engine design, the Upgraded Mod I (a redesign to incorporate new materials for cost/weight reduction and improved performance).

  19. Search for a pentaquark decaying to <i>pK>0S in <i>γN>

    SciTech Connect

    Link, J. M.; Yager, P. M.; Anjos, J. C.; Bediaga, I.; Castromonte, C.; Machado, A. A.; Magnin, J.; Massafferri, A.; de Miranda, J. M.; Pepe, I. M.; Polycarpo, E.; dos Reis, A. C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sánchez-Hernández, A.; Uribe, C.; Vázquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J. P.; Frisullo, V.; O'Reilly, B.; Segoni, I.; Stenson, K.; Butler, J. N.; Cheung, H. W. K.; Chiodini, G.; Gaines, I.; Garbincius, P. H.; Garren, L. A.; Gottschalk, E.; Kasper, P. H.; Kreymer, A. E.; Kutschke, R.; Wang, M.; Benussi, L.; Bertani, M.; Bianco, S.; Fabbri, F. L.; Pacetti, S.; Zallo, A.; Reyes, M.; Cawlfield, C.; Kim, D. Y.; Rahimi, A.; Wiss, J.; Gardner, R.; Kryemadhi, A.; Chung, Y. S.; Kang, J. S.; Ko, B. R.; Kwak, J. W.; Lee, K. B.; Cho, K.; Park, H.; Alimonti, G.; Barberis, S.; Boschini, M.; Cerutti, A.; D'Angelo, P.; DiCorato, M.; Dini, P.; Edera, L.; Erba, S.; Inzani, P.; Leveraro, F.; Malvezzi, S.; Menasce, D.; Mezzadri, M.; Moroni, L.; Pedrini, D.; Pontoglio, C.; Prelz, F.; Rovere, M.; Sala, S.; Davenport, T. F.; Arena, V.; Boca, G.; Bonomi, G.; Gianini, G.; Liguori, G.; Lopes Pegna, D.; Merlo, M. M.; Pantea, D.; Ratti, S. P.; Riccardi, C.; Vitulo, P.; Göbel, C.; Olatora, J.; Hernandez, H.; Lopez, A. M.; Mendez, H.; Paris, A.; Quinones, J.; Ramirez, J. E.; Zhang, Y.; Wilson, J. R.; Handler, T.; Mitchell, R.; Engh, D.; Givens, K. M.; Hosack, M.; Johns, W. E.; Luiggi, E.; Nehring, M.; Sheldon, P. D.; Vaandering, E. W.; Webster, M.; Sheaff, M.

    2006-08-01

    We present a search for a pentaquark decaying strongly to <i>pK>0S in <i>γN> collisions at a center-of-mass energy up to 25 GeV/c2. Finding no evidence for such a state in the mass range of 1470 MeV/c2 to 2200 MeV/c2, we set limits on the yield and on the cross section times branching ratio relative to Σ* (1385)± and K* (892) +.

  20. Quality control of MHC class I maturation.

    PubMed

    Paulsson, Kajsa M; Wang, Ping

    2004-01-01

    Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tapasin, an important component of the LC, interacts with COPI-coated vesicles. Biochemical studies suggested that the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules from the Golgi network back to the ER. Also other findings now propose that in addition to the peptide-loading control, the quality control of MHC class I antigen presentation includes the restriction of export of suboptimally loaded MHC class I molecules to the cell surface. In this review, we use recent studies of tapasin to examine the efficiency of TAP, the LC constitution, ER quality control of class I assembly, and peptide optimization. The concepts of MHC class I recycling and ER retention are also discussed. PMID:14718384

  1. Trilinos I/O Support (Trios)

    DOE PAGES

    Oldfield, Ron A.; Sjaardema, Gregory D.; Lofstead II, Gerald F.; Kordenbrock, Todd

    2012-01-01

    Trilinos I/O Support (Trios) is a new capability area in Trilinos that serves two important roles: (1) it provides and supports I/O libraries used by in-production scientific codes; (2) it provides a research vehicle for the evaluation and distribution of new techniques to improve I/O on advanced platforms. This paper provides a brief overview of the production-grade I/O libraries in Trios as well as some of the ongoing research efforts that contribute to the experimental libraries in Trios.

  2. The I2Cnet service architecture paradigm.

    PubMed

    Zabulis, X; Chronaki, C; Orphanoudakis, S

    1997-01-01

    The main objective of the Image Indexing by Content network (I2Cnet) is to provide network-transparent content-based access to medical image archives based on a collection of interoperable Internet/intranet added-value services. This paper discusses I2Cnet, focusing on its service architecture paradigm. I2Cnet services such as image annotation, processing, description, and content-based retrieval, as well as the on-line collaboration service are presented. Exemplary user sessions are used to illustrate how virtual workspaces facilitate the interoperation of I2Cnet services, following the "network computer" approach to information management.

  3. File concepts for parallel I/O

    NASA Technical Reports Server (NTRS)

    Crockett, Thomas W.

    1989-01-01

    The subject of input/output (I/O) was often neglected in the design of parallel computer systems, although for many problems I/O rates will limit the speedup attainable. The I/O problem is addressed by considering the role of files in parallel systems. The notion of parallel files is introduced. Parallel files provide for concurrent access by multiple processes, and utilize parallelism in the I/O system to improve performance. Parallel files can also be used conventionally by sequential programs. A set of standard parallel file organizations is proposed, organizations are suggested, using multiple storage devices. Problem areas are also identified and discussed.

  4. Recurrent thyrotoxicosis after I-131 induced hypothyroidism

    SciTech Connect

    Liu, L.; Borowski, G.D.; Shtasel, P.; Rose, L.I.

    1984-01-01

    The first clinically and biochemically documented case of recurrent thyrotoxicosis after I-131 induced hypothyroidism in a patient with Graves' disease is reported. Two months after the administration of 9.2 mCi of I-131, the subject developed hypothyroidism. One month later, the patient became euthyroid. Then, nine months following ablation, the patient again developed thyrotoxicosis. A second dose of I-131 of 12.5 mCi was required to finally produce permanent hypothyroidism. This case illustrates the recurrence of hypothyroidism after what had seemed to have been adequate I-131 radiation.

  5. Papilloedema due to Chiari I malformation.

    PubMed

    Zhang, Jason Chao; Bakir, Belal; Lee, Andrew; Yalamanchili, Sushma S

    2011-10-16

    The Chiari I malformation is a congenital abnormality characterised by downward displacement of the cerebellar tonsils through the foramen magnum into the cervical spine. It presents clinically most often in young adult women. Known ocular manifestations linked to Chiari I consist primarily of oculomotor paresis with cranial nerve VI palsy and convergence/divergence abnormalities. Papilloedema is a rare manifestation of Chiari I with a clinical presentation often similar to that of idiopathic intracranial hypertension. To highlight this unusual complication, the authors report a 64-year-old female who developed papilloedema as the only presenting neurological symptom resulting from a Chiari I malformation.

  6. 21 CFR 803.40 - If I am an importer, what kinds of individual adverse event reports must I submit, when must I...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... adverse event reports must I submit, when must I submit them, and to whom must I submit them? 803.40... importer, what kinds of individual adverse event reports must I submit, when must I submit them, and to whom must I submit them? (a) Reports of deaths or serious injuries. You must submit a report to us,...

  7. Anti-j: human cold agglutinins recognizing linear (i) and branched (I) type 2 chains.

    PubMed

    Roelcke, D; Kreft, H; Hack, H; Stevenson, F K

    1994-01-01

    Two IgM lambda cold agglutinins (CAs) reacted with protease- and sialidase-resistant antigens expressed in equal strength on human adult (I), newborn (i), i adult, rabbit (I) and rhesus monkey (i) erythrocytes. The antibodies were inhibited by the linear type 2 sequence lacto-N-neotetraose and the branched type 2 sequence lacto-N-neohexaose. Endo-beta-galactosidase treatment of red cells, which splits type 2 chains from the surface, abolished CA reactivity. The CAs expressed the idiotype recognized by the anti-idiotype 9G4 specific for anti-I and anti-i CAs. The data suggest that the two CAs recognize linear (i) as well as branched (I) type 2 chains. It is proposed to term these CAs anti-j.

  8. Monoclonal antibodies to the major Lolium perenne (rye grass) pollen allergen Lol p I (Rye I).

    PubMed

    Kahn, C R; Marsh, D G

    1986-12-01

    Thirteen monoclonal antibodies (MAbs) were produced against Lol p I (Rye I), the major Lolium perenne (rye grass) pollen allergen. Spleen cells from A/J and SJL mice immunized with highly purified Lol p I (Lol I) were allowed to fuse with cells from the non-secreting Sp2/0-Ag14 myeloma cell line. Each MAb was analyzed for antigenic specificity by radioimmunoassay (RIA) using 125I-Lol I. The epitope specificities of seven of the MAbs were examined by competitive binding against a labelled standard MAb for the Lol I antigen (Ag). The dissociation constant, Kd, of one MAb (No. 3.2) that was studied most extensively was determined by double Ab RIA to be 3.5 X 10(-6) L/M. This MAb recognized the related 27,000-30,000 Group I glycoproteins found in the pollens of nine other species of grass pollens tested, including weak binding to Bermuda grass Group I (Cyn d I), which by conventional analysis using polyclonal anti-Lol I serum shows no detectable binding. Monoclonal antibody No. 3.2 was coupled covalently to Sepharose 4B and used to prepare highly purified Lol I from a partially purified rye pollen extract. Finally, an RIA was developed which permitted the analysis of the Group I components in rye grass and nine other grass pollen species. The latter assay is likely to prove useful in the standardization of grass pollen extracts according to their Group I contents.

  9. Ag(I)-binding to phytochelatins.

    PubMed

    Mehra, R K; Tran, K; Scott, G W; Mulchandani, P; Saini, S S

    1996-02-01

    Phytochelatins (PCs) are glutathione-derived peptides with the general structure (gamma-Glu-Cys)nGly, where n varies from 2 to 11. A variety of metal ions such as Cu(II), Cd(II), Pb(II), Zn(II), and Ag(I) induce PC synthesis in plants and some yeasts. It has generally been assumed that the inducer metals also bind PCs. However, very little information is available on the binding of metals other than Cu(I) and Cd(II) to PCs. In this paper, we describe the Ag(I)-binding characteristics of PCs with the structure (gamma-Glu-Cys)2Gly, (gamma-Glu-Cys)3Gly, and (gamma-Glu-Cys)4Gly. The Ag(I)-binding stoichiometries of these three peptides were determined by (i) UV/VIS spectrophotometry, (ii) luminescence spectroscopy at 77 K, and (iii) reverse-phase HPLC. The three techniques yielded similar results. ApoPCs exhibit featureless absorption in the 220-340 nm range. The binding of Ag(I) to PCs induced the appearance of specific absorption shoulders. The titration end point was indicated by the flattening of the characteristic absorption shoulders. Similarly, luminescence at 77 K due to Ag(I)-thiolate clusters increased with the addition of graded Ag(I) equivalents. The luminescence declined when Ag(I) equivalents in excess of the saturating amounts were added to the peptides. At neutral pH, (gamma-Glu-Cys)2Gly, (gamma-Glu-Cys)3Gly, and (gamma-Glu-Cys)4Gly bind 1.0, 1.5, and 4.0 equivalents of Ag(I), respectively. The Ag(I)-binding capacity of (gamma-Glu-Cys)2Gly and (gamma-Glu-Cys)3Gly was increased at pH 5.0 and below so that Ag(I)/-SH ratio approached 1.0. A similar pH-dependent binding of Ag(I) to glutathione was also observed. The increased Ag(I)-binding to PCs at lower pH is of physiological significance as these peptides accumulate in acidic vacuoles. We also report lifetime data on Ag(I)-PCs. The relatively long decay-times (approximately 0.1-0.3 msec) accompanied with a large Stokes shift in the emission band are indicative of spin-forbidden phosphorescence. PMID

  10. iTOUGH2 Command Reference

    SciTech Connect

    Finsterle, Stefan

    2002-06-18

    iTOUGH2 is a program for parameter estimation, sensitivity analysis, and uncertainty propagation analysis. It is based on the TOUGH2 simulator for non-isothermal multiphase flow in fractured and porous media. This report contains a detailed description of all iTOUGH2 commands.

  11. Benzo[g,h,i]perylene

    Integrated Risk Information System (IRIS)

    Benzo [ g , h , i ] perylene ; CASRN 191 - 24 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonc

  12. FOUNDATIONS OF THAI. BOOK I, PART 1.

    ERIC Educational Resources Information Center

    ANTHONY, EDWARD M.; AND OTHERS

    THIS BEGINNING TEXT PRESENTS THE ESSENTIALS OF THAI PRONUNCIATION AND GRAMMAR IN A FORMAT GEARED TO REGULAR COLLEGE LANGUAGE COURSE SCHEDULING. THE COURSE CONSISTS OF TWO VOLUMES, BOOK I, PART 1 (LESSONS 1-14) AND BOOK I, PART 2 (LESSONS 15-25), PROVIDING MATERIAL FOR TWO UNIVERSITY SEMESTERS OF CLASSROOM AND LABORATORY WORK. BASED ON A…

  13. Learning Chinese Idioms through iPads

    ERIC Educational Resources Information Center

    Yang, Chunsheng; Xie, Ying

    2013-01-01

    This paper reports on an action research study using iPads during the teaching of Chinese idioms to heritage learners. A class of 12 second-year Chinese learners were engaged in a self-generated learning process focused on learning abstract and concrete idioms using iPads. Students' short-term and long-term learning was measured; feedback…

  14. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  15. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  16. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  17. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  18. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  19. Bone Marrow Transplantation for Feline Mucopolysaccharidosis I

    PubMed Central

    Ellinwood, N. Matthew; Colle, Marie-Anne; Weil, Margaret A.; Casal, Margret L.; Vite, Charles H.; Wiemelt, Staci; Hasson, Christopher W.; O’Malley, Thomas M.; He, Xingxuan; Prociuk, Ulana; Verot, Lucie; Melniczek, John R.; Lannon, Anne; Aguirre, Gustavo D.; Knox, Van W.; Evans, Sydney M.; Vanier, Marie T.; Schuchman, Edward H.; Walkley, Steven U.; Haskins, Mark E.

    2009-01-01

    Severe mucopolysaccharidosis type I (MPS I) is a fatal neuropathic lysosomal storage disorder with significant skeletal involvement. Treatment involves bone marrow transplantation (BMT), and although effective, is suboptimal, due to treatment sequelae and residual disease. Improved approaches will need to be tested in animal models and compared to BMT. Herein we report on bone marrow transplantation to treat feline mucopolysaccharidosis I (MPS I). Five MPS I stably engrafted kittens, transplanted with unfractionated bone marrow (6.3 × 107 to 1.1 × 109 nucleated bone marrow cells per kilogram) were monitored for 13–37 months post-engraftment. The tissue total glycosaminoglycan (GAG) content was reduced to normal levels in liver, spleen, kidney, heart muscle, lung, and thyroid. Aorta GAG content was between normal and affected levels. Treated cats had a significant decrease in the brain GAG levels relative to untreated MPS I cats and a paradoxical decrease relative to normal cats. The α-L-iduronidase (IDUA) activity in the livers and spleens of transplanted MPS I cats approached heterozygote levels. In kidney cortex, aorta, heart muscle, and cerebrum, there were decreases in GAG without significant increases in detectable IDUA activity. Treated animals had improved mobility and decreased radiographic signs of disease. However, significant pathology remained, especially in the cervical spine. Corneal clouding appeared improved in some animals. Immunohistochemical and biochemical analysis documented decreased central nervous system ganglioside storage. This large animal MPS I study will serve as a benchmark of future therapies designed to improve on BMT. PMID:17482862

  20. Using iPads to Your Advantage

    ERIC Educational Resources Information Center

    Zakrzewski, Jennifer L.

    2016-01-01

    In this article, middle school mathematics teacher Jennifer Zakrzewski describes how she successfully incorporated iPads and Apple TV (for projection of iPad screens) into her classroom while having her students solve a problem about mangoes. As Zakrzewski began a unit on multiplying and dividing fractions, she chose to start with the Mangoes…

  1. Complete genome sequence of <i>Bacillus amyloliquefaciensi> strain Co1-6, a plant growth-promoting rhizobacterium of <i>Calendula officinalisi>

    SciTech Connect

    Köberl, Martina; White, Richard A.; Erschen, Sabine; Spanberger, Nora; El-Arabi, Tarek F.; Jansson, Janet K.; Berg, Gabriele

    2015-08-13

    The genome sequence of <i>Bacillus amyloliquefaciensi> strain Co1-6, a plant growth-promoting rhizobacterium (PGPR) with broad-spectrum antagonistic activity against plant-pathogenic fungi, bacteria, and nematodes, consists of a single 3.9-Mb circular chromosome. The genome reveals genes putatively responsible for its promising biocontrol and PGP properties.

  2. Tobacco Addiction: 'Why Do I Smoke?' Quiz

    MedlinePlus

    MENU Return to Web version Tobacco Addiction | “Why do I smoke?" Quiz Why do I smoke? If you learn the answer to this question, it will be easier to ... m hooked." In addition to having a psychological addiction to smoking, you may also be physically addicted ...

  3. Connect the Book. I Face the Wind

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    This month's feature is Vicki Cobb's "I Face the Wind" (Illus. by Julia Gorton. HarperCollins, 2003) which introduces the wind's characteristics and actions through experiments and observations complemented with Gorton's creative illustrations. "I Face the Wind" was a 2004 Sibert Honor Book. The Sibert Award and Honor books are awarded annually to…

  4. RIG-I Works Double Duty

    PubMed Central

    Chan, Ying Kai; Gack, Michaela U.

    2016-01-01

    The pathogen sensor RIG-I recognizes viral RNA and signals to induce an antiviral response. In this issue of Cell Host & Microbe, Weber et al. (2015), along with recent work by Sato et al. (2015), demonstrate that RIG-I directly inhibits viral replication independent of antiviral signaling. PMID:25766287

  5. Investigation of structural heterogeneity at the SPE site using combined <i>P>–wave travel times and <i>Rg> phase velocities

    SciTech Connect

    Rowe, Charlotte A.; Patton, Howard J.

    2015-10-01

    Here, we present analyses of the 2D seismic structure beneath Source Physics Experiments (SPE) geophone lines that extended radially at 100 m spacing from 100 to 2000 m from the source borehole. With seismic sources at only one end of the geophone lines, standard refraction profiling methods cannot resolve seismic velocity structures unambiguously. In previous work, we demonstrated overall agreement between body-wave refraction modeling and <i>Rg> dispersion curves for the least complex of the five lines. A more detailed inspection supports a 2D reinterpretation of the structure. We obtained <i>Rg> phase velocity measurements in both the time and frequency domains, then used iterative adjustment of the initial 1D body-wave model to predict <i>Rg> dispersion curves to fit the observed values. Our method applied to the most topographically severe of the geophone lines is supplemented with a 2D ray-tracing approach, whose application to P-wave arrivals supports the <i>Rg> analysis. In addition, midline sources will allow us to refine our characterization in future work.

  6. First Graders with iPads?

    ERIC Educational Resources Information Center

    Getting, Sara; Swainey, Karin

    2012-01-01

    Giving iPads to first graders is a leap of faith that many teachers are understandably hesitant to take, especially if their students need immediate reading intervention and school leaders want guaranteed results. This article discusses how the authors took on the challenge of improving elementary reading using iPads, found surprising success for…

  7. British I.T.A. Research.

    ERIC Educational Resources Information Center

    Downing, John

    1968-01-01

    The conclusions and recommendations drawn from a 7-year study of the Initial Teaching Alphabet (i/t/a) made by the Reading Research Unit of London University are reported. The British research showed conclusively that traditional orthography (TO) is a major handicap for teachers and students of reading. Students taught with i/t/a made…

  8. iTOUGH2 Sample Problems

    SciTech Connect

    Finsterle, Stefan

    2002-06-18

    iTOUGH2 is a program for parameter estimation, sensitivity analysis, and uncertainty propagation analysis. It is based on the TOUGH2 simulator for non-isothermal multiphase flow in fractured and porous media. This report contains a collection of iTOUGH2 sample problems.

  9. Listening Habits of iPod Users

    ERIC Educational Resources Information Center

    Epstein, Michael; Marozeau, Jeremy; Cleveland, Sandra

    2010-01-01

    Purpose: To estimate real-environment iPod listening levels for listeners in 4 environments to gain insight into whether average listeners receive dosages exceeding occupational noise exposure guidelines as a result of their listening habits. Method: The earbud outputs of iPods were connected directly into the inputs of a digital recorder to make…

  10. Echinacea: What Should I Know about It?

    MedlinePlus

    ... Web version Echinacea: What Should I Know About It? Echinacea: What Should I Know About It? What is echinacea? Echinacea (say: "eck-in-ay- ... take echinacea on an empty stomach. Instead, take it with food or a large glass of water. ...

  11. Sports participation with Chiari I malformation.

    PubMed

    Strahle, Jennifer; Geh, Ndi; Selzer, Béla J; Bower, Regina; Himedan, Mai; Strahle, MaryKathryn; Wetjen, Nicholas M; Muraszko, Karin M; Garton, Hugh J L; Maher, Cormac O

    2016-04-01

    OBJECT There is currently no consensus on the safety of sports participation for patients with Chiari I malformation (CM-I). The authors' goal was to define the risk of sports participation for children with the imaging finding of CM-I. METHODS A prospective survey was administered to 503 CM-I patients at 2 sites over a 46-month period. Data were gathered on imaging characteristics, treatment, sports participation, and any sport-related injuries. Additionally, 81 patients completed at least 1 subsequent survey following their initial entry into the registry and were included in a prospective group, with a mean prospective follow-up period of 11 months. RESULTS Of the 503 CM-I patients, 328 participated in sports for a cumulative duration of 4641 seasons; 205 of these patients participated in contact sports. There were no serious or catastrophic neurological injuries. One patient had temporary extremity paresthesias that resolved within hours, and this was not definitely considered to be related to the CM-I. In the prospective cohort, there were no permanent neurological injuries. CONCLUSIONS No permanent or catastrophic neurological injuries were observed in CM-I patients participating in athletic activities. The authors believe that the risk of such injuries is low and that, in most cases, sports participation by children with CM-I is safe.

  12. A multiplet table for Mn I

    NASA Technical Reports Server (NTRS)

    Adelman, S. J.; Svatek, G. F.; Van Winkler, K.; Warren, W. H., Jr.

    1989-01-01

    A mulitplet table of the atomic spectral lines of Mn I has been prepared. All of the known lines and many predicted lines of Mn I are included in the table. The methodology used to prepare the table is outlined and a sample page of the table is given.

  13. Synthesis and bioactivity of Luffarin I.

    PubMed

    Urosa, Aitor; Marcos, Isidro S; Díez, David; Lithgow, Anna; Plata, Gabriela B; Padrón, José M; Basabe, Pilar

    2015-04-01

    The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12-17 μM. PMID:25903281

  14. How Can I Deal with My Asthma?

    MedlinePlus

    ... Who Cuts? How Can I Deal With My Asthma? KidsHealth > For Teens > How Can I Deal With My Asthma? Print A A A Text Size What's in ... Tips en español ¿Cómo puedo afrontar mi asma? Asthma is more common these days than it used ...

  15. In iPod We Trust

    ERIC Educational Resources Information Center

    Blaisdell, Mikael

    2006-01-01

    Beloved by students worldwide, iPod is becoming a presence in the classroom as teachers discover its many educational uses. At heart, the iPod's appeal is about its easily accessible audio and visual content in an attractive and conveniently sized package. Mechanically, the product is mostly a hard disk drive (although some models use only flash…

  16. Great Expectations: Understanding the New Title I.

    ERIC Educational Resources Information Center

    Manasevit, Leigh M.; Cowan, Kristen Tosh

    On October 20, 1994, President Clinton signed into law the Improving America's Schools Act of 1994. This statute contains amendments to the Elementary and Secondary Education Act of 1965, including the reauthorization of Chapter 1, as the newly entitled Title I. The reauthorized Title I drastically restructures the direction of former remedial…

  17. Structural, functional and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from <i>Neisseria meningitidisi> and <i>Brucella abortusi>

    SciTech Connect

    Pratt, Ashley J.; DiDonato, Michael; Shin, David S.; Cabelli, Diane E.; Bruns, Cami K.; Belzer, Carol A.; Gorringe, Andrew R.; Langford, Paul R.; Tabatabai, Louisa B.; Kroll, J. Simon; Tainer, John A.; Getzoff, Elizabeth D.

    2015-10-12

    Bacterial pathogens <i>Neisseria meningitidisi> and <i>Brucella abortusi> pose threats to human and animal health worldwide, causing meningococcal disease and brucellosis, respectively. Mortality from acute <i>N. meningitidisi> infections remains high despite antibiotics, and brucellosis presents alimentary and health consequences. Superoxide dismutases are master regulators of reactive oxygen, general pathogenicity factors and therefore therapeutic targets. Cu,Zn superoxide dismutases (SODs) localized to the periplasm promote survival by detoxifying superoxide radicals generated by major host antimicrobial immune responses. We discovered that passive immunization with an antibody directed at <i>N. meningitidisi> SOD (NmSOD) was protective in a mouse infection model. To define the relevant atomic details and solution assembly states of this important virulence factor, we report high-resolution and X-ray scattering analyses of NmSOD and SOD from <i>B. abortusi> (BaSOD). The NmSOD structures revealed an auxiliary tetrahedral Cu-binding site bridging the dimer interface; mutational analyses suggested that this metal site contributes to protein stability, with implications for bacterial defense mechanisms. Biochemical and structural analyses informed us about electrostatic substrate guidance, dimer assembly and an exposed C-terminal epitope in the NmSOD dimer. In contrast, the monomeric BaSOD structure provided insights for extending immunogenic peptide epitopes derived from the protein. These collective results reveal unique contributions of SOD to pathogenic virulence, refine predictive motifs for distinguishing SOD classes and suggest general targets for anti-bacterial immune responses. The identified functional contributions, motifs, and targets distinguishing bacterial and eukaryotic SOD assemblies presented here provide a foundation for efforts to develop SOD-specific inhibitors or vaccines against these harmful pathogens.

    IMPORTANCE By

  18. Structural, functional and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from <i>Neisseria meningitidisi> and <i>Brucella abortusi>

    SciTech Connect

    Pratt, Ashley J.; DiDonato, Michael; Shin, David S.; Cabelli, Diane E.; Bruns, Cami K.; Belzer, Carol A.; Gorringe, Andrew R.; Langford, Paul R.; Tabatabai, Louisa B.; Kroll, J. Simon; Tainer, John A.; Getzoff, Elizabeth D.

    2015-10-12

    Bacterial pathogens <i>Neisseria meningitidisi> and <i>Brucella abortusi> pose threats to human and animal health worldwide, causing meningococcal disease and brucellosis, respectively. Mortality from acute <i>N. meningitidisi> infections remains high despite antibiotics, and brucellosis presents alimentary and health consequences. Superoxide dismutases are master regulators of reactive oxygen, general pathogenicity factors and therefore therapeutic targets. Cu,Zn superoxide dismutases (SODs) localized to the periplasm promote survival by detoxifying superoxide radicals generated by major host antimicrobial immune responses. We discovered that passive immunization with an antibody directed at <i>N. meningitidisi> SOD (NmSOD) was protective in a mouse infection model. To define the relevant atomic details and solution assembly states of this important virulence factor, we report high-resolution and X-ray scattering analyses of NmSOD and SOD from <i>B. abortusi> (BaSOD). The NmSOD structures revealed an auxiliary tetrahedral Cu-binding site bridging the dimer interface; mutational analyses suggested that this metal site contributes to protein stability, with implications for bacterial defense mechanisms. Biochemical and structural analyses informed us about electrostatic substrate guidance, dimer assembly and an exposed C-terminal epitope in the NmSOD dimer. In contrast, the monomeric BaSOD structure provided insights for extending immunogenic peptide epitopes derived from the protein. These collective results reveal unique contributions of SOD to pathogenic virulence, refine predictive motifs for distinguishing SOD classes and suggest general targets for anti-bacterial immune responses. The identified functional contributions, motifs, and targets distinguishing bacterial and eukaryotic SOD assemblies presented here provide a foundation for efforts to develop SOD-specific inhibitors or vaccines against these harmful pathogens.

    IMPORTANCE By

  19. Parvalbumins from coelacanth muscle. I. General survey.

    PubMed

    Jauregui-Adell, J; Pechere, J F

    1978-09-26

    Parvalbumins from coelacanth (Latimeria chalumnae) myogen have been isolated by gel filtration of Sephadex G-75 and DEAE-cellulose chromatography. Disc electrophoresis and cellulose acetate electrophoresis showed the homogeneity of the three first major parvalbumin peaks (pI = 5.44, pI = 4.95 and pI = 4.52). The fourth component was partially resolved into two more parvalbumins (pI = 3.78 and pI = 3.50) by preparative gel electrophoresis. Amino acid analyses and tryptic peptide maps separated the five components in two major categories. The two less acidic components differ only in the presence or absence of an N-terminal blocking group. The three more acidic components constitute the second category; in spite of this heterogeneity, they share the same amino acid sequence.

  20. [Latest advances of SLA class I genes].

    PubMed

    Tao, Xuan; Li, Hua; Li, Xue-Wei; Yu, Hui; Zuo, Qi-Zhen

    2007-11-01

    The Swine leukocyte antigen (SLA) class I genes encode multi-glycoproteins on cell surface, which present endogenous antigenic peptides to T cells and thus initiate specific immune responses. In this article, latest advances on molecular structure, expression in tissues, regulation of expression, genotyping, polymorphism, and evolution of SLA class I genes were introduced, in which genotyping and polymorphism were emphasized. Molecular typing methods of SLA class I genes include serological method, DNA sequencing, PCR-SSP, PCR-SSOP and MS, of which PCR-SSP is frequently used in genotyping of SLA class I genes as a simple and rapid method. Future directions for the study and application of SLA class I genes on gene functions, peptide vaccine, xenotransplantation were also discussed.

  1. Complex I function in mitochondrial supercomplexes.

    PubMed

    Lenaz, Giorgio; Tioli, Gaia; Falasca, Anna Ida; Genova, Maria Luisa

    2016-07-01

    This review discusses the functional properties of mitochondrial Complex I originating from its presence in an assembled form as a supercomplex comprising Complex III and Complex IV in stoichiometric ratios. In particular several lines of evidence are presented favouring the concept that electron transfer from Complex I to Complex III is operated by channelling of electrons through Coenzyme Q molecules bound to the supercomplex, in contrast with the hypothesis that the transfer of reducing equivalents from Complex I to Complex III occurs via random diffusion of the Coenzyme Q molecules in the lipid bilayer. Furthermore, another property provided by the supercomplex assembly is the control of generation of reactive oxygen species by Complex I. This article is part of a Special Issue entitled Respiratory Complex I, edited by Volker Zickermann and Ulrich Brandt.

  2. Mitochondrial complex I-linked disease.

    PubMed

    Rodenburg, Richard J

    2016-07-01

    Complex I deficiency is the most frequently encountered single mitochondrial single enzyme deficiency in patients with a mitochondrial disorder. Although specific genotype-phenotype correlations are very difficult to identify, the majority of patients present with symptoms caused by leukodystrophy. The poor genotype-phenotype correlations can make establishing a diagnosis a challenge. The classical way to establish a complex I deficiency in patients is by performing spectrophotometric measurements of the enzyme in a muscle biopsy or other patient-derived material (liver or heart biopsy, cultured skin fibroblasts). Complex I is encoded by both the mtDNA and nuclear DNA and pathogenic mutations have been identified in the majority of the 44 genes encoding the structural subunits of complex I. In recent years, the increasing possibilities for diagnostic molecular genetic tests of large gene panels, exomes, and even entire genomes has led to the identification of many novel genetic defects causing complex I deficiency. Complex I mutations not only result in a reduced enzyme activity but also induce secondary effects at the cellular level, such as elevated reactive oxygen species production, altered membrane potential and mitochondrial morphology. At this moment there is no cure for complex I deficiency and the treatment options for complex I patients are restricted to symptomatic treatment. Recent developments, amongst others based on the treatment of the secondary effects of complex I deficiency, have shown to be promising as new therapeutic strategies in vitro and have entered clinical trials. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt.

  3. Structural, functional and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from <i>Neisseria meningitidisi> and <i>Brucella abortusi>

    SciTech Connect

    Cabelli, Diane E.; Pratt, Ashley J.; DiDonato, Michael; Shin, David S.; Bruns, Cami K.; Belzer, Carol A.; Gorringe, Andrew R.; Langford, Paul R.; Tabatabai, Louisa B.; Kroll, J. Simon; Tainer, John A.; Getzoff, Elizabeth D.

    2015-12-01

    Bacterial pathogens <i>Neisseria meningitidisi> and <i>Brucella abortusi> pose threats to human and animal health worldwide, causing meningococcal disease and brucellosis, respectively. Mortality from acute <i>N. meningitidisi> infections remains high despite antibiotics, and brucellosis presents alimentary and health consequences. Superoxide dismutases are master regulators of reactive oxygen and general pathogenicity factors and are therefore therapeutic targets. Cu,Zn superoxide dismutases (SODs) localized to the periplasm promote survival by detoxifying superoxide radicals generated by major host antimicrobial immune responses. We discovered that passive immunization with an antibody directed at <i>N. meningitidisi> SOD (NmSOD) was protective in a mouse infection model. To define the relevant atomic details and solution assembly states of this important virulence factor, we report high-resolution and X-ray scattering analyses of NmSOD and of SOD from <i>B. abortusi> (BaSOD). The NmSOD structures revealed an auxiliary tetrahedral Cu-binding site bridging the dimer interface; mutational analyses suggested that this metal site contributes to protein stability, with implications for bacterial defense mechanisms. Biochemical and structural analyses informed us about electrostatic substrate guidance, dimer assembly, and an exposed C-terminal epitope in the NmSOD dimer. In contrast, the monomeric BaSOD structure provided insights for extending immunogenic peptide epitopes derived from the protein. These collective results reveal unique contributions of SOD to pathogenic virulence, refine predictive motifs for distinguishing SOD classes, and suggest general targets for antibacterial immune responses. Furthermore, the identified functional contributions, motifs, and targets distinguishing bacterial and eukaryotic SOD assemblies presented here provide a foundation for efforts to develop SOD-specific inhibitors of or vaccines against these harmful pathogens.

  4. RIG-I in RNA virus recognition

    PubMed Central

    Kell, Alison M.; Gale, Michael

    2015-01-01

    Antiviral immunity is initiated upon host recognition of viral products via non-self molecular patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition initiates signaling cascades that induce intracellular innate immune defenses and an inflammatory response that facilitates development of the acquired immune response. The retinoic acid-inducible gene I (RIG-I) and the RIG-I-like receptor (RLR) protein family are key cytoplasmic pathogen recognition receptors that are implicated in the recognition of viruses across genera and virus families, including functioning as major sensors of RNA viruses, and promoting recognition of some DNA viruses. RIG-I, the charter member of the RLR family, is activated upon binding to PAMP RNA. Activated RIG-I signals by interacting with the adapter protein MAVS leading to a signaling cascade that activates the transcription factors IRF3 and NF-κB. These actions induce the expression of antiviral gene products and the production of type I and III interferons that lead to an antiviral state in the infected cell and surrounding tissue. RIG-I signaling is essential for the control of infection by many RNA viruses. Recently, RIG-I crosstalk with other pathogen recognition receptors and components of the inflammasome has been described. In this review, we discuss the current knowledge regarding the role of RIG-I in recognition of a variety of virus families and its role in programming the adaptive immune response through cross-talk with parallel arms of the innate immune system, including how RIG-I can be leveraged for antiviral therapy. PMID:25749629

  5. VUV Photofragmentation of CH2I2: The [CH2I-I](•+) Iso-diiodomethane Intermediate in the I-Loss Channel from [CH2I2](•.).

    PubMed

    Cartoni, Antonella; Casavola, Anna Rita; Bolognesi, Paola; Borocci, Stefano; Avaldi, Lorenzo

    2015-04-23

    Diiodomethane is an important halocarbon responsible for several atmospheric processes like ozone depletion and aerosol particle formation. Despite this, the thermochemical data and a detailed analysis of the pathways for the decomposition of this halomethane and its molecular ion [CH2I2](•+) are scarce. In this paper an investigation of the photodissociation dynamics of the CH2I2 molecule focused on the I-loss channel by the photoelectron-photoion coincidence (PEPICO) technique and computational methods is reported. The experimental results show that upon VUV irradiation the dissociation of the lower electronic ionic states of diiodomethane leads only to the CH2I(+) ion and the I atom. The theoretical calculations point out that isomerization of [CH2I2](•+) into iso-diiodomethane [CH2I-I](•+) may play an important role in the emission of iodine atom as compared to direct C-I bond breaking. PMID:25866871

  6. Classical trajectory simulation of the cluster-atom association reaction I-Arn+I --> I2+nAr. I. Capture of iodine by the I(Ar)12 cluster

    NASA Astrophysics Data System (ADS)

    Hu, Xiche; Martens, Craig C.

    1993-06-01

    The atom-cluster association reaction I(Ar)n+I→I2+nAr (n=12) is studied theoretically as a prototypical model of the effect of microscopic solvation on reaction dynamics. Classical trajectory methods are employed to model the dynamics. This paper focuses on the initial capture of I by the I(Ar)12 cluster. Two distinct minimum energy configurations for I(Ar)12 are considered: Ar6(I)Ar6, an icosahedron with I located at the center of the cluster; and IAr12, an icosahedron with I replacing one of the vertex Ar atoms. Both the structure and the temperature dependence of the capture cross section are investigated. Capture rate constants at temperatures of 10 and 30 K are computed. Capture cross sections for Ar6(I)Ar6+I predicted by a Langevin model agree well with those computed by classical trajectory simulation, revealing that the capture process under investigation is determined by the long range interaction potential. In comparison with its gas phase counterpart I+I, Ar6(I)Ar6+I has a much larger capture cross section. One of the most important roles played by the microscopic solvation of chemical reactants in clusters is this enhancement of the cross section for the initial capture process.

  7. Flood-Frequency Estimates for Streams on Kaua`i, O`ahu, Moloka`i, Maui, and Hawai`i, State of Hawai`i

    USGS Publications Warehouse

    Oki, Delwyn S.; Rosa, Sarah N.; Yeung, Chiu W.

    2010-01-01

    This study provides an updated analysis of the magnitude and frequency of peak stream discharges in Hawai`i. Annual peak-discharge data collected by the U.S. Geological Survey during and before water year 2008 (ending September 30, 2008) at stream-gaging stations were analyzed. The existing generalized-skew value for the State of Hawai`i was retained, although three methods were used to evaluate whether an update was needed. Regional regression equations were developed for peak discharges with 2-, 5-, 10-, 25-, 50-, 100-, and 500-year recurrence intervals for unregulated streams (those for which peak discharges are not affected to a large extent by upstream reservoirs, dams, diversions, or other structures) in areas with less than 20 percent combined medium- and high-intensity development on Kaua`i, O`ahu, Moloka`i, Maui, and Hawai`i. The generalized-least-squares (GLS) regression equations relate peak stream discharge to quantified basin characteristics (for example, drainage-basin area and mean annual rainfall) that were determined using geographic information system (GIS) methods. Each of the islands of Kaua`i,O`ahu, Moloka`i, Maui, and Hawai`i was divided into two regions, generally corresponding to a wet region and a dry region. Unique peak-discharge regression equations were developed for each region. The regression equations developed for this study have standard errors of prediction ranging from 16 to 620 percent. Standard errors of prediction are greatest for regression equations developed for leeward Moloka`i and southern Hawai`i. In general, estimated 100-year peak discharges from this study are lower than those from previous studies, which may reflect the longer periods of record used in this study. Each regression equation is valid within the range of values of the explanatory variables used to develop the equation. The regression equations were developed using peak-discharge data from streams that are mainly unregulated, and they should not be used to

  8. 13 CFR 134.616 - How will I know if I receive an award?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Implementation of the Equal Access to Justice Act § 134.616 How will I know if I receive an award? The ALJ will issue an initial decision on...

  9. Process for depositing I-125 onto a substrate used to manufacture I-125 sources

    DOEpatents

    McGovern, James J.; Olynyk, Joseph M.

    1988-01-01

    The invention relates to a process for depositing I-125 on a substrate which comprises contacting a predetermined surface area of substrate with Xe-125 gas, whereby the Xe-125 decays to I-125 and the I-125 in turn deposits as a solid on the surface of the substrate, the contact being for a time sufficient to deposit at least about 1 microcurie of I-125. I-125 is thereby deposited in a relatively uniform amount over the surface area of the substrate. The substrate is then assayed to determine how much I-125 has been deposited. The substrate is then divided into pieces of measured surface area, each piece therefore containing a measured amount of deposited I-125, and each piece can then be used in the manufacture of an I-125 source.

  10. Dynamics of the F(-) + CH3I → HF + CH2I(-) Proton Transfer Reaction.

    PubMed

    Zhang, Jiaxu; Xie, Jing; Hase, William L

    2015-12-17

    Direct chemical dynamics simulations, at collision energies Erel of 0.32 and 1.53 eV, were performed to obtain an atomistic understanding of the F(-) + CH3I reaction dynamics. There is only the F(-) + CH3I → CH3F + I(-) bimolecular nucleophilic substitution SN2 product channel at 0.32 eV. Increasing Erel to 1.53 eV opens the endothermic F(-) + CH3I → HF + CH2I(-) proton transfer reaction, which is less competitive than the SN2 reaction. The simulations reveal proton transfer occurs by two direct atomic-level mechanisms, rebound and stripping, and indirect mechanisms, involving formation of the F(-)···HCH2I complex and the roundabout. For the indirect trajectories all of the CH2I(-) is formed with zero-point energy (ZPE), while for the direct trajectories 50% form CH2I(-) without ZPE. Without a ZPE constraint for CH2I(-), the reaction cross sections for the rebound, stripping, and indirect mechanisms are 0.2 ± 0.1, 1.2 ± 0.4, and 0.7 ± 0.2 Å(2), respectively. Discarding trajectories that do not form CH2I(-) with ZPE reduces the rebound and stripping cross sections to 0.1 ± 0.1 and 0.7 ± 0.5 Å(2). The HF product is formed rotationally and vibrationally unexcited. The average value of J is 2.6 and with histogram binning n = 0. CH2I(-) is formed rotationally excited. The partitioning between CH2I(-) vibration and HF + CH2I(-) relative translation energy depends on the treatment of CH2I(-) ZPE. Without a CH2I(-) ZPE constraint the energy partitioning is primarily to relative translation with little CH2I(-) vibration. With a ZPE constraint, energy partitioning to CH2I(-) rotation, CH2I(-) vibration, and relative translation are statistically the same. The overall F(-) + CH3I rate constant at Erel of both 0.32 and 1.53 eV is in good agreement with experiment and negligibly affected by the treatment of CH2I(-) ZPE, since the SN2 reaction is the major contributor to the total reaction rate constant. The potential energy surface and reaction dynamics for F

  11. Dynamics of the F(-) + CH3I → HF + CH2I(-) Proton Transfer Reaction.

    PubMed

    Zhang, Jiaxu; Xie, Jing; Hase, William L

    2015-12-17

    Direct chemical dynamics simulations, at collision energies Erel of 0.32 and 1.53 eV, were performed to obtain an atomistic understanding of the F(-) + CH3I reaction dynamics. There is only the F(-) + CH3I → CH3F + I(-) bimolecular nucleophilic substitution SN2 product channel at 0.32 eV. Increasing Erel to 1.53 eV opens the endothermic F(-) + CH3I → HF + CH2I(-) proton transfer reaction, which is less competitive than the SN2 reaction. The simulations reveal proton transfer occurs by two direct atomic-level mechanisms, rebound and stripping, and indirect mechanisms, involving formation of the F(-)···HCH2I complex and the roundabout. For the indirect trajectories all of the CH2I(-) is formed with zero-point energy (ZPE), while for the direct trajectories 50% form CH2I(-) without ZPE. Without a ZPE constraint for CH2I(-), the reaction cross sections for the rebound, stripping, and indirect mechanisms are 0.2 ± 0.1, 1.2 ± 0.4, and 0.7 ± 0.2 Å(2), respectively. Discarding trajectories that do not form CH2I(-) with ZPE reduces the rebound and stripping cross sections to 0.1 ± 0.1 and 0.7 ± 0.5 Å(2). The HF product is formed rotationally and vibrationally unexcited. The average value of J is 2.6 and with histogram binning n = 0. CH2I(-) is formed rotationally excited. The partitioning between CH2I(-) vibration and HF + CH2I(-) relative translation energy depends on the treatment of CH2I(-) ZPE. Without a CH2I(-) ZPE constraint the energy partitioning is primarily to relative translation with little CH2I(-) vibration. With a ZPE constraint, energy partitioning to CH2I(-) rotation, CH2I(-) vibration, and relative translation are statistically the same. The overall F(-) + CH3I rate constant at Erel of both 0.32 and 1.53 eV is in good agreement with experiment and negligibly affected by the treatment of CH2I(-) ZPE, since the SN2 reaction is the major contributor to the total reaction rate constant. The potential energy surface and reaction dynamics for F

  12. Elucidating central metabolic redox obstacles hindering ethanol production in <i>Clostridium thermocellumi>

    SciTech Connect

    Thompson, R. Adam; Layton, Donovan S.; Guss, Adam M.; Olson, Daniel G.; Lynd, Lee R.; Trinh, Cong T.

    2015-10-21

    <i>Clostridium thermocellumi> is an anaerobic, Gram-positive, thermophilic bacterium that has generated great interest due to its ability to ferment lignocellulosic biomass to ethanol. However, ethanol production is low due to the complex and poorly understood branched metabolism of <i>C. thermocellumi>, and in some cases overflow metabolism as well. In this work, we developed a predictive stoichiometric metabolic model for <i>C. thermocellumi> which incorporates the current state of understanding, with particular attention to cofactor specificity in the atypical glycolytic enzymes and the complex energy, redox, and fermentative pathways with the goal of aiding metabolic engineering efforts. We validated the model s capability to encompass experimentally observed phenotypes for the parent strain and derived mutants designed for significant perturbation of redox and energy pathways. Metabolic flux distributions revealed significant alterations in key metabolic branch points (e.g., phosphoenol pyruvate, pyruvate, acetyl-CoA, and cofactor nodes) in engineered strains for channeling electron and carbon fluxes for enhanced ethanol synthesis, with the best performing strain doubling ethanol yield and titer compared to the parent strain. <i>In silicoi> predictions of a redox-imbalanced genotype incapable of growth were confirmed <i>in vivoi>, and a mutant strain was used as a platform to probe redox bottlenecks in the central metabolism that hinder efficient ethanol production. The results highlight the robustness of the redox metabolism of <i>C. thermocellumi> and the necessity of streamlined electron flux from reduced ferredoxin to NAD(P)H for high ethanol production. The model was further used to design a metabolic engineering strategy to phenotypically constrain <i>C. thermocellumi> to achieve high ethanol yields while requiring minimal genetic manipulations. Furthermore, the model can be applied to design <i>C. thermocellumi> as a platform microbe for

  13. I'm a Map, I'm a Green Tree

    ERIC Educational Resources Information Center

    Anderson, Daniel

    2010-01-01

    I'm talking about the ways we represent ourselves and our world. I've put some thoughts on the topic together here--a gathering that enacts new media creating and takes up conceptual layers like metaphors, models, and composing. The primary sources are videos from the Get a Mac campaign, aka I'm a Mac; I'm a PC ads. Posthuman concepts blending…

  14. Fluoride, bifluoride and trifluoromethyl complexes of iridium(I) and rhodium(I).

    PubMed

    Truscott, Byron J; Nahra, Fady; Slawin, Alexandra M Z; Cordes, David B; Nolan, Steven P

    2015-01-01

    Herein we report robust methods for the preparation and full characterisation of a range of Ir(I) and Rh(I) fluoride and bifluoride complexes using N-heterocyclic carbenes (NHCs) as ancillary ligands. The processes that link the fluoride and the bifluoride species are investigated and reports of the first Ir-bifluoride and Ir(I)-NHC and Rh(I)-NHC trifluoromethyl complexes are revealed.

  15. Identification of the meiotic toolkit in diatoms and exploration of meiosis-specific <i>SPO11i> and <i>RAD51i> homologs in the sexual species <i>Pseudo-nitzschia multistriatai> and <i>Seminavis robustai>

    SciTech Connect

    Patil, Shrikant; Moeys, Sara; von Dassow, Peter; Huysman, Marie J. J.; Mapleson, Daniel; De Veylder, Lieven; Sanges, Remo; Vyverman, Wim; Montresor, Marina; Ferrante, Maria Immacolata

    2015-11-14

    Sexual reproduction is an obligate phase in the life cycle of most eukaryotes. Meiosis varies among organisms, which is reflected by the variability of the gene set associated to the process. Diatoms are unicellular organisms that belong to the stramenopile clade and have unique life cycles that can include a sexual phase. The exploration of five diatom genomes and one diatom transcriptome led to the identification of 42 genes potentially involved in meiosis. While these include the majority of known meiosis-related genes, several meiosis-specific genes, including <i>DMC1i>, could not be identified. Furthermore, phylogenetic analyses supported gene identification and revealed ancestral loss and recent expansion in the <i>RAD51i> family in diatoms. The two sexual species Pseudo-nitzschia multistriata and Seminavis robusta were used to explore the expression of meiosis-related genes: <i>RAD21, SPO11-2, RAD51-A, RAD51-Bi> and <i>RAD51-Ci> were upregulated during meiosis, whereas other paralogs in these families showed no differential expression patterns, suggesting that they may play a role during vegetative divisions. An almost identical toolkit is shared among <i>Pseudo-nitzschia multiseriesi> and <i>Fragilariopsis cylindrusi>, as well as two species for which sex has not been observed, <i>Phaeodactylum tricornutumi> and <i>Thalassiosira pseudonanai>, suggesting that these two may retain a facultative sexual phase. Lastly, our results reveal the conserved meiotic toolkit in six diatom species and indicate that Stramenopiles share major modifications of canonical meiosis processes ancestral to eukaryotes, with important divergences in each Kingdom.

  16. Verification of Ares I Liftoff Acoustic Environments via the Ares I Scale Model Acoustic Test

    NASA Technical Reports Server (NTRS)

    Counter, Douglas; Houston, Janice

    2012-01-01

    The Ares I Scale Model Acoustic Test (ASMAT) program was implemented to verify the predicted Ares I liftoff acoustic environments and to determine the acoustic reduction gained by using an above deck water sound suppression system. The test article included a 5% scale Ares I vehicle model and Mobile Launcher with tower. Acoustic and pressure data were measured by over 200 instruments. The ASMAT results are compared to Ares I-X flight data.

  17. Mapping of epitopes on Poa p I and Lol p I allergens with monoclonal antibodies.

    PubMed

    Lin, Z W; Ekramoddoullah, A K; Jaggi, K S; Dzuba-Fischer, J; Rector, E; Kisil, F T

    1990-01-01

    Allergen Poa p I isolated from the dialysed aqueous extract of Kentucky blue grass pollen by affinity chromatography with an anti-Lol p I murine monoclonal antibody (MAb) 290A-167 was previously shown to consist of a 35.8-kilodalton (kD) component with a pI of 6.4, designated as Poa p Ia, and a 33-kD component with a pI of 9.1, designated as Poa p Ib. The present study reports on the comparative antigenic analyses of these two components, using MAbs produced separately against Poa p I and Lol p I. Thus, anti-Poa p I MAbs 60 and 61 and anti-Lol p I MAb 290A-167 recognized Poa p Ia and Poa p Ib whereas anti-Poa p I MAbs 62, 63 and 64 and anti-Lol p I MAb 348A-6 recognized only Poa p Ia. The specificities of the MAbs were further resolved by comparing their respective abilities to inhibit the binding of 125I-Poa p I or 125I-Lol p I to the different MAbs prepared in the form of solid phase. These studies revealed that at least 4 distinct epitopes (designated as E1, E2, E3 and E4) were shared by both Poa p I and Lol p I. All 4 epitopes were present on Poa p Ia whereas only E1 and E3 were detected on Poa p Ib. E1 was recognized by MAbs 60 and 61, E2 by MAbs 62, 63 and 64, E3 by MAb 290A-167 and E4 by MAb 348A-6.(ABSTRACT TRUNCATED AT 250 WORDS)

  18. Extraction of (129)I and (127)I via combustion from organic rich samples using (125)I as a quantitative tracer.

    PubMed

    Herod, Matthew N; Cornett, R Jack; Clark, Ian D; Kieser, W E; Jean, Gilles St

    2014-12-01

    Iodine-129 ((129)I) is a biophilic, naturally occurring radioisotope (half-life: 1.57 × 10(7) years) that has been released in large quantities by nuclear fuel reprocessing. This iodine has cycled throughout the globe and chiefly the northern hemisphere and can be found in a wide variety of environmental materials, particularly organic rich soil and organic matter. Extracting iodine reliably from solid samples has been done by a variety of methods, however, pyrohydrolysis has been the most widely used. There is a wide variation between existing pyrohydrolysis techniques and this raises questions about the quantitative recovery of iodine from method to method. In order to quantify iodine recovery from pyrohydrolysis we have spiked samples with an iodine-125 radiotracer prior to combustion and trapping in an alkaline solution. Inorganic (125)I tracer was used as well as humic acid labeled with (125)I to simulate the behavior of (129)I and (127)I in complex organic substances and extract iodine regardless of how it is partitioned. Using these tracers we explored the effect on recovery of (125)I under a variety of combustion parameters. These include carrier gas flow rate and iodine volatilization temperature. We observed that the best recoveries of (125)I were at flow rates between 400 and 800 mL/min and most (125)I recoveries were above 85%. The experiment to determine the temperature at which iodine volatilizes from the sample showed two distinct trends for the release of iodine. One trend showed that most iodine is released at approximately 525 °C, while the other trend showed that the samples needed to reach 800 °C and remain there for at least an hour. These findings illustrate the usefulness and importance of using a quantitative recovery tracer for every iodine extraction. We then combusted and precipitated several Atlantic Ocean seaweed and standard reference materials for AMS analysis as AgI. The (129)I concentration of the seaweed ranged between 4

  19. Extraction of (129)I and (127)I via combustion from organic rich samples using (125)I as a quantitative tracer.

    PubMed

    Herod, Matthew N; Cornett, R Jack; Clark, Ian D; Kieser, W E; Jean, Gilles St

    2014-12-01

    Iodine-129 ((129)I) is a biophilic, naturally occurring radioisotope (half-life: 1.57 × 10(7) years) that has been released in large quantities by nuclear fuel reprocessing. This iodine has cycled throughout the globe and chiefly the northern hemisphere and can be found in a wide variety of environmental materials, particularly organic rich soil and organic matter. Extracting iodine reliably from solid samples has been done by a variety of methods, however, pyrohydrolysis has been the most widely used. There is a wide variation between existing pyrohydrolysis techniques and this raises questions about the quantitative recovery of iodine from method to method. In order to quantify iodine recovery from pyrohydrolysis we have spiked samples with an iodine-125 radiotracer prior to combustion and trapping in an alkaline solution. Inorganic (125)I tracer was used as well as humic acid labeled with (125)I to simulate the behavior of (129)I and (127)I in complex organic substances and extract iodine regardless of how it is partitioned. Using these tracers we explored the effect on recovery of (125)I under a variety of combustion parameters. These include carrier gas flow rate and iodine volatilization temperature. We observed that the best recoveries of (125)I were at flow rates between 400 and 800 mL/min and most (125)I recoveries were above 85%. The experiment to determine the temperature at which iodine volatilizes from the sample showed two distinct trends for the release of iodine. One trend showed that most iodine is released at approximately 525 °C, while the other trend showed that the samples needed to reach 800 °C and remain there for at least an hour. These findings illustrate the usefulness and importance of using a quantitative recovery tracer for every iodine extraction. We then combusted and precipitated several Atlantic Ocean seaweed and standard reference materials for AMS analysis as AgI. The (129)I concentration of the seaweed ranged between 4

  20. Illustration of Ares I During Launch

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The NASA developed Ares rockets, named for the Greek god associated with Mars, will return humans to the moon and later take them to Mars and other destinations. In this early illustration, the Ares I is illustrated during lift off. Ares I is an inline, two-stage rocket configuration topped by the Orion crew vehicle and its launch abort system. With a primary mission of carrying four to six member crews to Earth orbit, Ares I may also use its 25-ton payload capacity to deliver resources and supplies to the International Space Station (ISS), or to 'park' payloads in orbit for retrieval by other spacecraft bound for the moon or other destinations. Ares I uses a single five-segment solid rocket booster, a derivative of the space shuttle solid rocket booster, for the first stage. A liquid oxygen/liquid hydrogen J-2X engine, derived from the J-2 engine used on the second stage of the Apollo vehicle, will power the Ares I second stage. Ares I can lift more than 55,000 pounds to low Earth orbit. The Ares I is subject to configuration changes before it is actually launched. This illustration reflects the latest configuration as of September 2006.

  1. Invited perspective: Why I am an optimist

    NASA Astrophysics Data System (ADS)

    Burges, Stephen J.

    2011-03-01

    I address a range of topics that provide the sociopolitical-technological setting for my professional life. I discuss some influential features of post-World War II world geopolitics, landmark technological developments of that era, and the resulting follow-up technologies that have made it possible to approach various problems in hydrology and water resources. I next address societal needs that have driven developments in hydrology and water resources engineering and follow with a discussion of the modern foundations of our science and what I think are the principal issues in hydrology. I pose three community challenges that when accomplished should advance hydrologic science: data network needs for improving the water budgets at all scales, characterizing subsurface water flow paths, and the information archiving and mining needs from instruments that will generate substantially richer data detail than have been used for most hydrologic work to the present. I then discuss several hydrologic and water resource risk-based decision issues that matter to society to illustrate how such risks have been addressed successfully in the past. I conclude with a long-term community "grand challenge," the coupled modeling of the ocean-atmosphere-landform hydrologic cycle for the purpose of long-lead time hydrologic prediction.

  2. Inhibition effects of I[sup [minus

    SciTech Connect

    Huang, Y.L.; Cao, C.N.; Lu, M.; Lin, H.C. . Corrosion Science Lab.)

    1993-08-01

    Stress corrosion cracking (SCC) of AISI 321 (UNS S321100) stainless steel (SS) in 0.5 mol/l sodium chloride (NaCl) + 0.5 mol/l hydrochloric acid (HCl) solution and the inhibition effects of some iodides and iodine were studied using the slow strain rate technique. Iodides studied were tetramethyl ammonium iodide (TMAI), tetrabutyl ammonium iodide (TBAI) and potassium iodide (KI). The additives effectively inhibited SCC of AISI 321 in the solution. Inhibition effects resulted mainly from the role of iodide ion. Electrochemical measurements showed the corrosion current density (I[sub corr]) of the steel increased rapidly and then fluctuated as strain increased. The increase in I[sub corr] was markedly slower in solutions containing I[minus] ions or I[sub 2]. Inhibition effects of I[minus] ions and I[sub 2] on SCC were attributed to the anodic reaction of the corrosion process and reduction of the accelerating effect of strain on I[sub corr].

  3. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false After I decommission a pipeline, what... SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit...

  4. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false After I decommission a pipeline, what... OUTER CONTINENTAL SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline,...

  5. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false After I decommission a pipeline, what... SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit...

  6. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After I decommission a pipeline, what... Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit a written report...

  7. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false After I decommission a pipeline, what... SHELF Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit...

  8. The shear fracture toughness, <i>KIIc>, of graphite

    SciTech Connect

    Burchell, Timothy D.; Erdman, III, Donald L.

    2015-11-05

    In this study, the critical shear stress intensity factor, <i>KIIc>, here-in referred to as the shear fracture toughness, <i>KIIc> (MPa m), of two grades of graphite are reported. The range of specimen volumes was selected to elucidate any specimen size effect, but smaller volume specimen tests were largely unsuccessful, shear failure did not occur between the notches as expected. This was probably due to the specimen geometry causing the shear fracture stress to exceed the compressive failure stress. In subsequent testing the specimen geometry was altered to reduce the compressive footprint and the notches (slits) made deeper to reduce the specimen's ligament length. Additionally, we added the collection of Acoustic Emission (AE) during testing to assist with the identification of the shear fracture load. The means of <i>KIIc> from large specimens for PCEA and NBG-18 are 2.26 MPa m with an SD of 0.37 MPa m and 2.20 MPa m with an SD of 0.53 MPa m, respectively. The value of <i>KIIc> for both graphite grades was similar, although the scatter was large. In this work we found the ratio of <i>KIIci>/KIc> ≈ 1.6. .

  9. 30 CFR 250.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false If I conduct ancillary activities, what notices must I provide? 250.208 Section 250.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... notices must I provide? At least 30 calendar days before you conduct any G&G exploration or development...

  10. 12 CFR 563b.520 - May I declare or pay dividends after I convert?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false May I declare or pay dividends after I convert? 563b.520 Section 563b.520 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY... dividends after I convert? You may declare or pay a dividend on your shares after you convert if: (a)...

  11. Detailed kinetic modeling study of <i>n>-pentanol oxidation

    SciTech Connect

    Heufer, K. Alexander; Sarathy, S. Mani; Curran, Henry J.; Davis, Alexander C.; Westbrook, Charles K.; Pitz, William J.

    2012-09-28

    To help overcome the world’s dependence upon fossil fuels, suitable biofuels are promising alternatives that can be used in the transportation sector. Recent research on internal combustion engines shows that short alcoholic fuels (e.g., ethanol or <i>n>-butanol) have reduced pollutant emissions and increased knock resistance compared to fossil fuels. Although higher molecular weight alcohols (e.g., <i>n>-pentanol and <i>n>-hexanol) exhibit higher reactivity that lowers their knock resistance, they are suitable for diesel engines or advanced engine concepts, such as homogeneous charge compression ignition (HCCI), where higher reactivity at lower temperatures is necessary for engine operation. The present study presents a detailed kinetic model for <i>n>-pentanol based on modeling rules previously presented for <i>n>-butanol. This approach was initially validated using quantum chemistry calculations to verify the most stable <i>n>-pentanol conformation and to obtain C–H and C–C bond dissociation energies. In addition, the proposed model has been validated against ignition delay time data, speciation data from a jet-stirred reactor, and laminar flame velocity measurements. Overall, the model shows good agreement with the experiments and permits a detailed discussion of the differences between alcohols and alkanes.

  12. Biodistribution and dosimetry of free 211At, 125I- and 131I- in rats.

    PubMed

    Spetz, Johan; Rudqvist, Nils; Forssell-Aronsson, Eva

    2013-11-01

    131I is widely used for therapy in the clinic and 125I and 131I, and increasingly 211At, are often used in experimental studies. It is important to know the biodistribution and dosimetry for these radionuclides to determine potential risk organs when using radiopharmaceuticals containing these radionuclides. The purpose of this study was to investigate the biodistribution of 125I-, 131I-, and free 211At in rats and to determine absorbed doses to various organs and tissues. Male Sprague Dawley rats were injected simultaneously with 0.1-0.3 MBq 125I- and 0.1-0.3 MBq 131I-, or 0.05-0.2 MBq 211At and sacrificed 1 hour to 7 days after injection. The activities and activity concentrations in organs and tissues were determined and mean absorbed doses were calculated. The biodistribution of 125I- was similar to that of 131I- but the biodistribution of free 211At was different compared to 125I- and 131I-. The activity concentration of radioiodine was higher compared with 211At in the thyroid and lower in all extrathyroidal tissues. The mean absorbed dose per unit injected activity was highest to the thyroid. 131I gave the highest absorbed dose to the thyroid, and 211At gave the highest absorbed dose to all other tissues studied. PMID:23789969

  13. 21 CFR 822.27 - If I go out of business, what must I do?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false If I go out of business, what must I do? 822.27 Section 822.27 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Responsibilities of Manufacturers § 822.27 If I go out...

  14. 21 CFR 822.27 - If I go out of business, what must I do?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false If I go out of business, what must I do? 822.27 Section 822.27 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Responsibilities of Manufacturers § 822.27 If I go out...

  15. 40 CFR Table I-1 to Subpart I of... - Default Emission Factors for Threshold Applicability Determination

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Default Emission Factors for Threshold Applicability Determination I Table I-1 to Subpart I of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING...

  16. 40 CFR Table I-1 to Subpart I - Default Emission Factors for Threshold Applicability Determination

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Default Emission Factors for Threshold Applicability Determination I Table I-1 to Subpart I Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Electronics Manufacturing Pt....

  17. 40 CFR Table I-1 to Subpart I of... - Default Emission Factors for Threshold Applicability Determination

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Default Emission Factors for Threshold Applicability Determination I Table I-1 to Subpart I of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING...

  18. How Do I Know What I Can Do? Anticipating Expectancy of Success Regarding Novel Academic Tasks

    ERIC Educational Resources Information Center

    Gorges, Julia; Göke, Thomas

    2015-01-01

    Background: After graduation from secondary school, academic tasks (i.e., learning contents) are no longer structured in terms of school subjects (i.e., English, mathematics). Therefore, learners lack past performance and mastery experience to inform their expectancy of success (i.e., ability beliefs) regarding novel tasks. Aims: In this paper, we…

  19. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Appendix I to Subpart B of Part 205 I Appendix I to Subpart B of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks...

  20. Biodistribution and dosimetry of free 211At, 125I- and 131I- in rats.

    PubMed

    Spetz, Johan; Rudqvist, Nils; Forssell-Aronsson, Eva

    2013-11-01

    131I is widely used for therapy in the clinic and 125I and 131I, and increasingly 211At, are often used in experimental studies. It is important to know the biodistribution and dosimetry for these radionuclides to determine potential risk organs when using radiopharmaceuticals containing these radionuclides. The purpose of this study was to investigate the biodistribution of 125I-, 131I-, and free 211At in rats and to determine absorbed doses to various organs and tissues. Male Sprague Dawley rats were injected simultaneously with 0.1-0.3 MBq 125I- and 0.1-0.3 MBq 131I-, or 0.05-0.2 MBq 211At and sacrificed 1 hour to 7 days after injection. The activities and activity concentrations in organs and tissues were determined and mean absorbed doses were calculated. The biodistribution of 125I- was similar to that of 131I- but the biodistribution of free 211At was different compared to 125I- and 131I-. The activity concentration of radioiodine was higher compared with 211At in the thyroid and lower in all extrathyroidal tissues. The mean absorbed dose per unit injected activity was highest to the thyroid. 131I gave the highest absorbed dose to the thyroid, and 211At gave the highest absorbed dose to all other tissues studied.

  1. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... run if I request a redetermination? If you request a redetermination after we have granted you...

  2. 29 CFR 2560.502i-1 - Civil penalties under section 502(i).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Civil penalties under section 502(i). 2560.502i-1 Section... RULES AND REGULATIONS FOR ADMINISTRATION AND ENFORCEMENT § 2560.502i-1 Civil penalties under section 502... the Act) permits the Secretary of Labor to assess a civil penalty against a party in interest...

  3. An approach for measuring the 129I/127I ratio in fish samples

    NASA Astrophysics Data System (ADS)

    Kusuno, Haruka; Matsuzaki, Hiroyuki; Nagata, Toshi; Miyairi, Yosuke; Yokoyama, Yusuke; Ohkouchi, Naohiko

    2015-10-01

    The 129I/127I ratio in marine fish samples was measured employing accelerator mass spectrometry. The measurement was successful because of the low experimental background of 129I. Pyrohydrolysis was applied to extract iodine from fish samples. The experimental background of pyrohydrolysis was checked carefully and evaluated as 104-105 atoms 129I/combustion. The methodology employed in the present study thus required only 0.05-0.2 g of dried fish samples. The methodology was then applied to obtain the 129I/127I ratio of marine fish samples collected from the Western Pacific Ocean as (0.63-1.2) × 10-10. These values were similar to the ratio for the surface seawater collected at the same station, 0.4 × 10-10. The 129I/127I ratio of IAEA-414, which was a mix of fish from the Irish Sea and the North Sea, was also measured and determined as 1.82 × 10-7. Consequently, fish from the Western Pacific Ocean and the North Sea were distinguished by their 129I/127I ratios. The 129I/127I ratio is thus a direct indicator of the area of habitat of fish.

  4. Dietary I(-) absorption: expression and regulation of the Na(+)/I(-) symporter in the intestine.

    PubMed

    Nicola, Juan Pablo; Carrasco, Nancy; Masini-Repiso, Ana María

    2015-01-01

    Thyroid hormones are critical for the normal development, growth, and functional maturation of several tissues, including the central nervous system. Iodine is an essential constituent of the thyroid hormones, the only iodine-containing molecules in vertebrates. Dietary iodide (I(-)) absorption in the gastrointestinal tract is the first step in I(-) metabolism, as the diet is the only source of I(-) for land-dwelling vertebrates. The Na(+)/I(-) symporter (NIS), an integral plasma membrane glycoprotein located in the brush border of enterocytes, constitutes a central component of the I(-) absorption system in the small intestine. In this chapter, we review the most recent research on structure/function relations in NIS and the protein's I(-) transport mechanism and stoichiometry, with a special focus on the tissue distribution and hormonal regulation of NIS, as well as the role of NIS in mediating I(-) homeostasis. We further discuss recent findings concerning the autoregulatory effect of I(-) on I(-) metabolism in enterocytes: high intracellular I(-) concentrations in enterocytes decrease NIS-mediated uptake of I(-) through a complex array of posttranscriptional mechanisms, e.g., downregulation of NIS expression at the plasma membrane, increased NIS protein degradation, and reduction of NIS mRNA stability leading to decreased NIS mRNA levels. Since the molecular identification of NIS, great progress has been made not only in understanding the role of NIS in I(-) homeostasis but also in developing protocols for NIS-mediated imaging and treatment of various diseases.

  5. 5 CFR 875.210 - What happens if I become ineligible after I submit an application?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What happens if I become ineligible after I submit an application? 875.210 Section 875.210 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility § 875.210 What happens if I...

  6. 49 CFR 512.19 - What can I do if I disagree with the determination?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false What can I do if I disagree with the determination? 512.19 Section 512.19 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONFIDENTIAL BUSINESS INFORMATION Agency Determination § 512.19 What can I...

  7. A network biology approach to denitrification in <i>Pseudomonas aeruginosai>

    SciTech Connect

    Arat, Seda; Bullerjahn, George S.; Laubenbacher, Reinhard

    2015-02-23

    <i>Pseudomonas aeruginosai> is a metabolically flexible member of the Gammaproteobacteria. Under anaerobic conditions and the presence of nitrate, <i>P. aeruginosai> can perform (complete) denitrification, a respiratory process of dissimilatory nitrate reduction to nitrogen gas via nitrite (NO₂), nitric oxide (NO) and nitrous oxide (N₂O). This study focuses on understanding the influence of environmental conditions on bacterial denitrification performance, using a mathematical model of a metabolic network in <i>P. aeruginosai>. To our knowledge, this is the <i>first> mathematical model of denitrification for this bacterium. Analysis of the long-term behavior of the network under changing concentration levels of oxygen (O₂), nitrate (NO₃), and phosphate (PO₄) suggests that PO₄ concentration strongly affects denitrification performance. The model provides three predictions on denitrification activity of <i>P. aeruginosai> under various environmental conditions, and these predictions are either experimentally validated or supported by pertinent biological literature. One motivation for this study is to capture the effect of PO₄ on a denitrification metabolic network of <i>P. aeruginosai> in order to shed light on mechanisms for greenhouse gas N₂O accumulation during seasonal oxygen depletion in aquatic environments such as Lake Erie (Laurentian Great Lakes, USA). Simulating the microbial production of greenhouse gases in anaerobic aquatic systems such as Lake Erie allows a deeper understanding of the contributing environmental effects that will inform studies on, and remediation strategies for, other hypoxic sites worldwide.

  8. 43 CFR 3505.30 - May I amend or change my application after I file it?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false May I amend or change my application after I file it? 3505.30 Section 3505.30 Public Lands: Interior Regulations Relating to Public Lands... amend or change my application after I file it? Yes. However, if your amendment adds lands, we...

  9. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  10. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  11. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  12. 43 CFR 3505.30 - May I amend or change my application after I file it?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false May I amend or change my application after I file it? 3505.30 Section 3505.30 Public Lands: Interior Regulations Relating to Public Lands... amend or change my application after I file it? Yes. However, if your amendment adds lands, we...

  13. 43 CFR 3505.31 - May I withdraw my application after I file it?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false May I withdraw my application after I file it? 3505.31 Section 3505.31 Public Lands: Interior Regulations Relating to Public Lands (Continued... withdraw my application after I file it? Yes. Just send us a written request. If you withdraw...

  14. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the Nine R/V Korr Cruises Comprising the Indian Ocean CO2Survey (WOCE Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2; December 1, 1994-January 19, 1996)

    SciTech Connect

    Kozyr, A.V.

    2003-09-15

    This document describes the procedures and methods used to measure total carbon dioxide (TCO{sub 2}) and total alkalinity (TALK) at hydrographic stations taken during the R/V Knorr Indian Ocean cruises (Sections I8SI9S, I9N, I8NI5E, I3, I5WI4, I7N, I1, I10, and I2) in 1994-1996. The measurements were conducted as part of the World Ocean Circulation Experiment (WOCE). The expedition began in Fremantle, Australia, on December 1, 1994, and ended in Mombasa, Kenya, on January 22, 1996. During the nine cruises, 12 WOCE sections were occupied. Total carbon dioxide was extracted from water samples and measured using single-operator multiparameter metabolic analyzers (SOMMAs) coupled to coulometers. The overall precision and accuracy of the analyses was {+-} 1.20 {micro}mol/kg. The second carbonate system parameter, TALK, was determined by potentiometric titration. The precision of the measurements determined from 962 analyses of certified reference material was {+-} 4.2 {micro}mol/kg (REFERENCE). This work was supported by grants from the National Science Foundation, the U. S. Department of Energy, and the National Oceanographic and Atmospheric Administration. The R/V Knorr Indian Ocean data set is available as a numeric data package (NDP) from the Carbon Dioxide Information Analysis Center (CDIAC). The NDP consists of 18 oceanographic data files, two FORTRAN 77 data retrieval routine files, a readme file, and this printed documentation, which describes the contents and format of all files as well as the procedures and methods used to obtain the data. Instructions for accessing the data are provided.

  15. Emission properties and Cu(i)-Cu(i) interaction in 2-coordinate dicopper(i)-bis(N-heterocyclic)carbene complexes.

    PubMed

    Nishikawa, Michihiro; Sano, Taichi; Washimi, Masaya; Takao, Koichiro; Tsubomura, Taro

    2016-07-26

    The synthesis, characterization, and emission properties of 2-coordinate dicopper(i) complexes bearing two trimethylene-bridged bis-NHC ligands, [Cu2(L3Me)2](PF6)2 (1), [Cu2(L3Et)2](PF6)2 (2), [Cu2(L3Bu)2](PF6)2 (3), [Cu2(L3MeOPh)2](PF6)2 (4) and [Cu2(L3Mes)2](PF6)2 (5), where L3R denotes trimethylene-bridged bis(N-heterocyclic)carbene (NHC) ligand substituted by two R groups at the nitrogen atoms of NHC, have been investigated. The quantum yield, Φ, and the lifetime, τ, of the emission of 2, are 0.21 and 25 μs, respectively in methanol, which is a well-known solvent for quenching the luminescence of many copper(i) complexes. The 8-shaped geometry of the dicopper(i) complexes brings a considerable copper(i)-copper(i) interaction which affects the luminescent properties. Additionally, we find that methoxyphenyl and mesityl groups substituted at the nitrogen atom of the NHC moiety drastically stabilize the bis(NHC) copper(i) complexes even in air-saturated acetone-d6. PMID:27399152

  16. Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation.

    PubMed Central

    Kingma, J. G.; Roy, P. E.

    1990-01-01

    The present study was undertaken to examine changes in vascular ultrastructure of rats subjected to hypervitaminosis D with or without treatment with ethane-I-hydroxy-I, I-diphosphonate (EHDP). Five groups of rats were studied. Untreated rats were given 0.9% NaCl i.p. Sham-treated rats were given vehicle (corn oil). Treated rats were given ergocalciferol (75,000 IU i.p.) dissolved in vehicle with or without EHDP (5 mM/100 g body-weight i.p.). Rats which had been given ergocalciferol without EHDP developed hypercalcemia and demonstrated significant arterial calcinosis. A similar degree of calcinosis was not observed in rats given ergocalciferol with EHDP. EHDP appeared to inhibit arterial calcinosis; however, it did not affect plasma calcium levels. This suggests that EHDP might delay calcium influx into the cell and thereby prevent calcium overload. Our findings support the suggestion that EHDP therapy can be an effective treatment for the inhibition of dystrophic arterial calcinosis. Images Fig. 2 Fig. 3 Fig. 4 PMID:2109995

  17. Chaos and localization in the wave functions of complex atoms Nd I, Pm I, and Sm I

    SciTech Connect

    Angom, Dilip; Kota, V.K.B.

    2005-04-01

    Wave functions of complex lanthanide atoms Nd I, Pm I, and Sm I, obtained via multiconfiguration Dirac-Fock method, are analyzed for density of states in terms of partial densities, strength functions [F{sub k}(E)], number of principal components [{xi}{sub 2}(E)], and occupancies ({sup E}) of single-particle orbits using embedded Gaussian orthogonal ensemble of one plus two-body random matrix ensembles [EGOE(1+2)]. It is seen that density of states are in general multi-modal, F{sub k}(E)'s exhibit variations as function of the basis states energy and {xi}{sub 2}(E)'s show structures arising from localized states. The sources of these departures from EGOE(1+2) are investigated by examining the partial densities, correlations between F{sub k}(E), {xi}{sub 2}(E), and {sup E} and also by studying the structure of the Hamiltonian matrices. These studies point out the operation of EGOE(1+2) but at the same time suggest that weak admixing between well separated configurations should be incorporated into EGOE(1+2) for more quantitative description of chaos and localization in Nd I, Pm I, and Sm I.

  18. Efficient algorithms for Hirshfeld-I charges

    SciTech Connect

    Finzel, Kati; Martín Pendás, Ángel; Francisco, Evelio

    2015-08-28

    A new viewpoint on iterative Hirshfeld charges is presented, whereby the atomic populations obtained from such a scheme are interpreted as such populations which reproduce themselves. This viewpoint yields a self-consistent requirement for the Hirshfeld-I populations rather than being understood as the result of an iterative procedure. Based on this self-consistent requirement, much faster algorithms for Hirshfeld-I charges have been developed. In addition, new atomic reference densities for the Hirshfeld-I procedure are presented. The proposed reference densities are N-representable, display proper atomic shell structure and can be computed for any charged species.

  19. Rational engineering of <i>Geobacter sulfurreducensi> electron transfer components: A foundation for building improved <i>Geobacter>-based bioelectrochemical technologies

    SciTech Connect

    Dantas, Joana M.; Morgado, Leonor; Aklujkar, Muktak; Bruix, Marta; Londer, Yuri Y.; Schiffer, Marianne; Pokkuluri, P. Raj; Salgueiro, Carlos A.

    2015-07-30

    Multiheme cytochromes have been implicated in <i>Geobacter sulfurreducensi> extracellular electron transfer (EET). These proteins are potential targets to improve EET and enhance bioremediation and electrical current production by <i>G. sulfurreducensi>. However, the functional characterization of multiheme cytochromes is particularly complex due to the co-existence of several microstates in solution, connecting the fully reduced and fully oxidized states. Throughout the last decade, new strategies have been developed to characterize multiheme redox proteins functionally and structurally. These strategies were used to reveal the functional mechanism of <i>G. sulfurreducensi> multiheme cytochromes and also to identify key residues in these proteins for EET. In previous studies, we set the foundations for enhancement of the EET abilities of <i>G. sulfurreducensi> by characterizing a family of five triheme cytochromes (PpcA-E). These periplasmic cytochromes are implicated in electron transfer between the oxidative reactions of metabolism in the cytoplasm and the reduction of extracellular terminal electron acceptors at the cell's outer surface. The results obtained suggested that PpcA can couple e-/H+ transfer, a property that might contribute to the proton electrochemical gradient across the cytoplasmic membrane for metabolic energy production. The structural and functional properties of PpcA were characterized in detail and used for rational design of a family of 23 single site PpcA mutants. In this review, we summarize the functional characterization of the native and mutant proteins. Mutants that retain the mechanistic features of PpcA and adopt preferential e-/H+ transfer pathways at lower reduction potential values compared to the wild-type protein were selected for in vivo studies as the best candidates to increase the electron transfer rate of <i>G. sulfurreducensi>. For the first time <i>G. sulfurreducensi

  20. Type I interferonopathies in pediatric rheumatology.

    PubMed

    Volpi, Stefano; Picco, Paolo; Caorsi, Roberta; Candotti, Fabio; Gattorno, Marco

    2016-01-01

    Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a constitutive activation of this pathway that might present as atypical, severe, early onset rheumatic diseases. Skin vasculopathy with chilblains and livedo reticularis, interstitial lung disease, and panniculitis are common. Recent studies have implicated abnormal responses to nucleic acid stimuli or defective regulation of downstream effector molecules in disease pathogenesis. As observed for IL1-β and autoinflammatory diseases, knowledge of the defects responsible for type I interferonopathies will likely promote the development of targeted therapy. PMID:27260006

  1. Yakov Abramovich as i Remember him

    NASA Astrophysics Data System (ADS)

    Nyíri, Julia

    2013-06-01

    I first heard of Yakov Abramovich when (being a student of the Leningrad State University) I read his papers written with Pomeranchuk and Landau [1]. Later, in my last year at the university, thinking about a possible future working place, I met G. Domokos who at that time was a researcher in Dubna. He gave me the advice to go to Dubna for a while and look for the possibility to work with Professor Smorodinsky who was the broadest-minded physicist he had ever met...

  2. I&C Modeling in SPAR Models

    SciTech Connect

    John A. Schroeder

    2012-06-01

    The Standardized Plant Analysis Risk (SPAR) models for the U.S. commercial nuclear power plants currently have very limited instrumentation and control (I&C) modeling [1]. Most of the I&C components in the operating plant SPAR models are related to the reactor protection system. This was identified as a finding during the industry peer review of SPAR models. While the Emergency Safeguard Features (ESF) actuation and control system was incorporated into the Peach Bottom Unit 2 SPAR model in a recent effort [2], various approaches to expend resources for detailed I&C modeling in other SPAR models are investigated.

  3. ApaI, BsmI, FokI, and TaqI Polymorphisms in the Vitamin D Receptor Gene and Parkinson's Disease

    PubMed Central

    Niu, Meng-Yue; Wang, Lei; Xie, An-Mu

    2015-01-01

    Background: The vitamin D receptor (VDR) gene has been identified as a candidate gene for susceptibility to Parkinson's disease (PD), but results from genetic association studies to date are inconsistent. Here, we conducted a meta-analysis of published case-control studies to evaluate the association of the extensively studied VDR ApaI (G/T), BsmI (G/A), FokI (C/T), and TaqI (T/C) gene polymorphisms with risk of PD. Methods: Electronic search at PubMed, EMBASE, EBSCO, China National Knowledge Infrastructure, Weipu database, and Wanfang database was conducted to identify all relevant studies. Odds ratio (OR) with 95% confidence interval (CI) values was applied to evaluate the strength of the association. Results: A total of seven studies with 2034 PD cases and 2432 controls were included in the meta-analysis following the inclusion and exclusion criteria. Overall, no significant association between ApaI, BsmI, and TaqI gene polymorphisms and PD susceptibility in all four genetic models was found (T vs. G: OR = 1.00, 95% CI: 0.89–1.12, P = 0.97; A vs. G: OR = 0.94, 95% CI: 0.77–1.15, P = 0.53; C vs. T: OR = 1.03, 95% CI: 0.85–1.25, P = 0.77) while a significant association between FokI (C/T) and PD risk was observed (C vs. T: OR = 1.41, 95% CI: 1.14–1.75, P = 0.001; CC vs. TT: OR = 2.45, 95% CI: 1.52–3.93, P = 0.0002; CT vs. TT: OR = 2.21, 95% CI: 1.38–3.52, P = 0.0009, CC vs. CT+TT: OR = 2.32, 95% CI: 1.49–3.61, P = 0.0002). Conclusions: Polymorphisms of ApaI, BsmI, and TaqI may not be associated with the susceptibility to PD while the FokI (C/T) polymorphism is possibly associated with increased PD risk. However, conclusions should be cautiously interpreted due to the relatively small number of studies included. PMID:26112724

  4. Impact of high 131I-activities on quantitative 124I-PET

    NASA Astrophysics Data System (ADS)

    Braad, P. E. N.; Hansen, S. B.; Høilund-Carlsen, P. F.

    2015-07-01

    Peri-therapeutic 124 I-PET/CT is of interest as guidance for radioiodine therapy. Unfortunately, image quality is complicated by dead time effects and increased random coincidence rates from high 131 I-activities. A series of phantom experiments with clinically relevant 124 I/131 I-activities were performed on a clinical PET/CT-system. Noise equivalent count rate (NECR) curves and quantitation accuracy were determined from repeated scans performed over several weeks on a decaying NEMA NU-2 1994 cylinder phantom initially filled with 25 MBq 124 I and 1250 MBq 131 I. Six spherical inserts with diameters 10-37 mm were filled with 124 I (0.45 MBq ml-1 ) and 131 I (22 MBq ml-1 ) and placed inside the background of the NEMA/IEC torso phantom. Contrast recovery, background variability and the accuracy of scatter and attenuation corrections were assessed at sphere-to-background activity ratios of 20, 10 and 5. Results were compared to pure 124 I-acquisitions. The quality of 124 I-PET images in the presence of high 131 I-activities was good and image quantification unaffected except at very high count rates. Quantitation accuracy and contrast recovery were uninfluenced at 131 I-activities below 1000 MBq, whereas image noise was slightly increased. The NECR peaked at 550 MBq of 131 I, where it was 2.8 times lower than without 131 I in the phantom. Quantitative peri-therapeutic 124 I-PET is feasible.

  5. Ares I-X Flight Test Vehicle Similitude to the Ares I Crew Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Huebner, Lawrence D.; Smith, R. Marshall; Campbell, John R., Jr.; Taylor, Terry L.

    2008-01-01

    The Ares I-X Flight Test Vehicle is the first in a series of flight test vehicles that will take the Ares I Crew Launch Vehicle design from development to operational capability. The test flight is scheduled for April 2009, relatively early in the Ares I design process so that data obtained from the flight can impact the design of Ares I before its Critical Design Review. Because of the short time frame (relative to new launch vehicle development) before the Ares I-X flight, decisions about the flight test vehicle design had to be made in order to complete analysis and testing in time to manufacture the Ares I-X vehicle hardware elements. This paper describes the similarities and differences between the Ares I-X Flight Test Vehicle and the Ares I Crew Launch Vehicle. Areas of comparison include the outer mold line geometry, aerosciences, trajectory, structural modes, flight control architecture, separation sequence, and relevant element differences. Most of the outer mold line differences present between Ares I and Ares I-X are minor and will not have a significant effect on overall vehicle performance. The most significant impacts are related to the geometric differences in Orion Crew Exploration Vehicle at the forward end of the stack. These physical differences will cause differences in the flow physics in these areas. Even with these differences, the Ares I-X flight test is poised to meet all five primary objectives and six secondary objectives. Knowledge of what the Ares I-X flight test will provide in similitude to Ares I as well as what the test will not provide is important in the continued execution of the Ares I-X mission leading to its flight and the continued design and development of Ares I.

  6. Interrogation of the <i>Burkholderia pseudomalleii> genome to address differential virulence among isolates

    SciTech Connect

    Challacombe, Jean F.; Stubben, Chris J.; Klimko, Christopher P.; Welkos, Susan L.; Kern, Steven J.; Bozue, Joel A.; Worsham, Patricia L.; Cote, Christopher K.; Wolfe, Daniel N.; Badger, Jonathan H.

    2014-12-23

    Infection by the Gram-negative pathogen <i>Burkholderia pseudomalleii> results in the disease melioidosis, acquired from the environment in parts of southeast Asia and northern Australia. Clinical symptoms of melioidosis range from acute (fever, pneumonia, septicemia, and localized infection) to chronic (abscesses in various organs and tissues, most commonly occurring in the lungs, liver, spleen, kidney, prostate and skeletal muscle), and persistent infections in humans are difficult to cure. Understanding the basic biology and genomics of <i>B. pseudomalleii> is imperative for the development of new vaccines and therapeutic interventions. This formidable task is becoming more tractable due to the increasing number of <i>B. pseudomalleii> genomes that are being sequenced and compared. Here, we compared three <i>B. pseudomalleii> genomes, from strains MSHR668, K96243 and 1106a, to identify features that might explain why MSHR668 is more virulent than K96243 and 1106a in a mouse model of <i>B. pseudomalleii> infection. Our analyses focused on metabolic, virulence and regulatory genes that were present in MSHR668 but absent from both K96243 and 1106a. We also noted features present in K96243 and 1106a but absent from MSHR668, and identified genomic differences that may contribute to variations in virulence noted among the three <i>B. pseudomalleii> isolates. While this work contributes to our understanding of <i>B. pseudomalleii> genomics, more detailed experiments are necessary to characterize the relevance of specific genomic features to <i>B. pseudomalleii> metabolism and virulence. Functional analyses of metabolic networks, virulence and regulation shows promise for examining the effects of <i>B. pseudomalleii> on host cell metabolism and will lay a foundation for future prediction of the virulence of emerging strains. Continued emphasis in this area will be critical for protection against melioidosis, as a better understanding of what

  7. Psych-related iPhone apps.

    PubMed

    Harrison, Anthony Mark; Goozee, Rhianna

    2014-02-01

    iPhone apps are a widely utilised technology that have recently been identified as a useful medium for health research, clinical interventions and education. While some researchers have discussed advances in app technology, others promote specific apps that are not free to access. To our knowledge, no study has conducted a review of current, free iPhone apps related to psychology, psychiatry and mental health. Therefore, we conducted a pilot, web-based review exploring free iPhone apps using a replicable search strategy within the iTunes Store search function. A selection of apps were selected and subjectively assessed in terms of their usability, utility, graphics, and associated costs for the consumer. We concluded that the apps reviewed, though novel, are limited in their scope and utility. We also note a significant gap in more scientific, evidence-based app technology, and pose some pertinent ethical questions when developing future psych-related apps.

  8. Production of SSM/I data sets

    NASA Technical Reports Server (NTRS)

    Wentz, Frank J.

    1992-01-01

    This Final Report is a summary of the work that was performed under Contract NAS8-38075 between NASA Marshall Space Flight Center and Remote Sensing Systems from September 1989 to September 1992. The primary accomplishment was the delivery of Special Sensor Microwave/Imager (SSM/I) data tapes containing sensor and geophysical products. In all, 515 tapes (80 gigabytes) were delivered. These tapes contained the F08 SSM/I data for the period from July 1988 through December 1991 and the F10 SSM/I data for the period from December 1990 through December 1991. For the F08 SSM/I, a data inventory was compiled and an engineering assessment was done. Ephemeris tables for the F08 and F10 spacecrafts were computed. Scientific studies on the oceanic wind vector and water vapor field were published, and color atlases of monthly ocean products were produced. This investigation was part of NASA's WETNET program.

  9. Tositumomab and Iodine I 131 Tositumomab

    Cancer.gov

    This page contains brief information about tositumomab and iodine I 131 tositumomab and a collection of links to more information about the use of this drug combination, research results, and ongoing clinical trials.

  10. Assessing DNA structures with 125I radioprobing.

    PubMed

    Gaynutdinov, Timur I; Neumann, Ronald D; Panyutin, Igor G

    2010-01-01

    Iodine-125 radioprobing is based on incorporation of radioiodine into a defined position in a nucleic acid molecule. Decay of (125)I results in the emission of multiple, low-energy Auger electrons that, along with positively charged residual daughter nuclide, produce DNA strand breaks. The probability of such strand breaks at a given nucleotide is in inverse proportion to the distance from the (125)I atom to the sugar of that nucleotide. Therefore, conclusions can be drawn about the conformation or folding of a DNA or RNA molecule based on the distribution of (125)I decay-induced strand breaks. Here we describe in detail the application (125)I radioprobing for studying the conformation of quadruplex structures, and discuss the advantages and limitations of the method. PMID:20012420

  11. Procedures for RIA I-125 waste disposal

    SciTech Connect

    Hidalgo, J.U.; Shepard, E.S.; Ball, J.M.; Colomb, K.D.

    1982-04-01

    I-125 can be effectively removed from coated tubes and plastic beads used as solid-phase separators by a 50% household bleach solution. This technique enables the user to dispose of these separators into common trash.

  12. Strongly Anisotropic Bianchi i Quantum Cosmology

    NASA Astrophysics Data System (ADS)

    Schmidt, Hans-Jürgen

    2002-12-01

    We report on the period-doubling bifurcation recently detected for strongly anisotropic Bianchi I quantum cosmology by M. Bachmann and H.-J. Schmidt and present further arguments related to the quantum boundary.

  13. Radioactive Iodine (I-131) Therapy for Hyperthyroidism

    MedlinePlus

    ... Iodine (I-131) Therapy Radioiodine therapy is a nuclear medicine treatment for an overactive thyroid, a condition ... locally overactive in producing too much thyroid hormone. Nuclear medicine is a branch of medical imaging that ...

  14. IGRINS observations toward Class I disk sources

    NASA Astrophysics Data System (ADS)

    Lee, Seokho; Lee, Jeong-Eun; Park, Sunkyung; Jaffe, Daniel T.; Lee, Jae-Joon

    2015-08-01

    We present the high-resolution Immersion GRating INfrared spectrograph (IGRINS) spectra of Class I sources, including IRAS03445+3242 and IRAS04239+2436. These sources show the evidence of Keplerian disks; the broadened CO overtone (Δ v=2) transitions in emission and neutral metal lines (Mg I, Fe I, and Al I) in absorption. The thin Keplerian disk with a rotational velocity of ~100 km s-1 and a gas temperature of 5000 K at the innermost annulus can reproduce the CO overtone transitions including the bandhead emission. The temperature is assumed to have a power-law distribution with p=0.5. The outer colder disk or the envelope needs to fit the narrow absorption features overlaid on the broad emission lines in the CO overtone transitions. Other atomic and molecular emission lines likely radiated from the disk and/or wind are also detected.

  15. <i>DShaper>: An approach for handling missing low-<i>Q> data in pair distribution function analysis of nanostructured systems

    SciTech Connect

    Olds, Daniel; Wang, Hsiu -Wen; Page, Katharine

    2015-01-01

    This study discusses the potential problems and currently available solutions in modeling powder-diffraction-based pair distribution function (PDF) data from systems where morphological feature information content includes distances in the nanometre length scale, such as finite nanoparticles, nanoporous networks and nanoscale precipitates in bulk materials. The implications of an experimental finite minimum<i>Q>value are reviewed by simulation, which also demonstrates the advantages of combining PDF data with small-angle scattering data. A simple Fortran90 code, <i>DShaper>, is introduced, which may be incorporated into PDF data fitting routines in order to approximate the so-called `shape function' for any atomistic model.

  16. The GALFA-H I Survey

    NASA Astrophysics Data System (ADS)

    Peek, J. E. G.; Begum, A.; Douglas, K. A.; Gibson, S. J.; Grcevich, J.; Heiles, C.; Korpela, E. J.; Lee, M.; Putman, M.; Saul, D. R.; Stanimirović, S.

    2010-12-01

    We present the GALFA-H I survey. GALFA-H I is an ongoing survey of neutral hydrogen (H I) in the Galaxy conducted at the 305 m Arecibo telescope. We briefly discuss the parameters of the survey, and the philosophy behind our observational strategy. We discuss the GALFA-H I survey in the context of other large area HI surveys, past, present, and future, and compare it to these surveys in terms of various observational parameters. We give a very brief overview of all the surveys being conducted with the ALFA instrument and discuss the importance of our commensal partnerships with a subset of these surveys. We discuss our current survey coverage, and describe our current and future data availability. We also briefly describe some of the science being conducted with the ongoing survey.

  17. Lane Detection on the iPhone

    NASA Astrophysics Data System (ADS)

    Ren, Feixiang; Huang, Jinsheng; Terauchi, Mutsuhiro; Jiang, Ruyi; Klette, Reinhard

    A robust and efficient lane detection system is an essential component of Lane Departure Warning Systems, which are commonly used in many vision-based Driver Assistance Systems (DAS) in intelligent transportation. Various computation platforms have been proposed in the past few years for the implementation of driver assistance systems (e.g., PC, laptop, integrated chips, PlayStation, and so on). In this paper, we propose a new platform for the implementation of lane detection, which is based on a mobile phone (the iPhone). Due to physical limitations of the iPhone w.r.t. memory and computing power, a simple and efficient lane detection algorithm using a Hough transform is developed and implemented on the iPhone, as existing algorithms developed based on the PC platform are not suitable for mobile phone devices (currently). Experiments of the lane detection algorithm are made both on PC and on iPhone.

  18. I-NERI 2004 Annual Report

    SciTech Connect

    2004-01-01

    The International Nuclear Energy Research Initiative (I-NERI) supports the National Energy Policy by conducting research to advance the state of nuclear science and technology in the United States (U.S.). I-NERI sponsors innovative scientific and engineering research and development (R&D) in cooperation with participating countries. The R&D research performed under the I-NERI umbrella addresses the key issues affecting the future of nuclear energy and its global deployment. I-NERI research is directed towards improving cost performance, increasing proliferation resistance, enhancing safety, and improving the waste management of future nuclear energy systems. This I-NERI 2004 Annual Report serves to inform interested parties on the program's organization, progress of the collaborative research projects, and future planning for the program. The report covers the four years of I-NERI activity since the program's inception in fiscal year (FY) 2001. The motivation and series of events that led to the creation of the I-NERI program are discussed in Section 2. The participating countries in current I-NERI collaborative agreements are also presented. Section 3 presents an overview of the I-NERI goals and objectives, a work scope summary for the collaborative projects, and a summary of research project awards through the end of FY 2004. It also includes FY 2005 accomplishments and planned FY 2005 activities. A summary of programmatic accomplishments is presented in Section 4. Also included is a summary of new and existing projects, an overview of the I-NERI program funding, and the new collaborations anticipated in FY 2005. The R&D work scope for current I-NERI collaborative projects with Canada, France, Japan, the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA), and the Republic of Korea are presented in Sections 5 through 9, respectively. For each participating country, an index of projects and a summary of FY 2004 technical

  19. Plasmic degradation of fibrinogen Paris I.

    PubMed

    Budzynski, A Z; Marder, V J

    1976-11-01

    Fibrin obtained from the plasma of a patient having abnormal fibrogen Paris I contains normal alpha, beta, and gamma polypeptide chains as well as an abnormal gamma-chain (gammaParis I) of approximately 51,000 daltons molecular weight. Plasmic digestion of Paris I fibrogen and noncrosslinked fibrin yields both normal and abnormal Fragment D molecules, the latter having a higher negative charge and molecular weight than that liberated from normal fibrinogen and noncorsslinked fibrin. After disulfide bond reduction, an abnormal polypeptide chain of approximately 40,500 +/- 2,000 daltons molecular weight was demonstrated in the Paris I digests by dodecyl sulfate (SDS) polyacrylamide gel electrophoresis. Comparison with the electrophoretic pattern for reduced digests of normal substrates indicates that it is a gamma-chain remnant in the normal Fragment D. Although the carbohydrate content in the gamma-Paris I-chain is slightly higher than that in the normal gamma-chain, as measured by periodic acid-Schiff reagent (PAS) staining intensity, it is concluded that extra carbohydrate does not account for the high molecular weight of the gamma-Paris I-chain since the 40,500 dalton chain does not stain with PAS. Plasma digestion of Paris I crosslinked fibrin yields a large amount of Fragment D in addition to Fragment D-D ("D-dimer") and E molecules, in contrast to a digest of normal crosslinked fibrin, from which only the latter two fragments are formed. This finding suggests that the defect in fibrinogen Paris I derives from an abnormality in the carboxy-terminal region of the gammaParis I-chain, so that in the presence of Factor XIII, these chains are not crosslinked and Fragment D-D molecules are not liberated upon subsequent plasmic degradation. The data provide support for the previous conclusion that a longer than normal polypeptide chain sequence at the carboxy-terminal portion of the gammaParis I-chains accounts for the increased size of these chains relative to the

  20. Interaction of the intron-encoded mobility endonuclease I-PpoI with its target site.

    PubMed Central

    Ellison, E L; Vogt, V M

    1993-01-01

    Endonucleases encoded by mobile group I introns are highly specific DNases that induce a double-strand break near the site to which the intron moves. I-PpoI from the acellular slime mold Physarum polycephalum mediates the mobility of intron 3 (Pp LSU 3) in the extrachromosomal nuclear ribosomal DNA of this organism. We showed previously that cleavage by I-PpoI creates a four-base staggered cut near the point of intron insertion. We have now characterized several further properties of the endonuclease. As determined by deletion analysis, the minimal target site recognized by I-PopI was a sequence of 13 to 15 bp spanning the cleavage site. The purified protein behaved as a globular dimer in sedimentation and gel filtration. In gel mobility shift assays in the presence of EDTA, I-PpoI formed a stable and specific complex with DNA, dissociating with a half-life of 45 min. By footprinting and interference assays with methidiumpropyl-EDTA-iron(II), I-PpoI contacted a 22- to 24-bp stretch of DNA. The endonuclease protected most of the purines found in both the major and minor grooves of the DNA helix from modification by dimethyl sulfate (DMS). However, the reactivity to DMS was enhanced at some purines, suggesting that binding leads to a conformational change in the DNA. The pattern of DMS protection differed fundamentally in the two partially symmetrical halves of the recognition sequence. Images PMID:8246971

  1. The origin of I in soil and the 129I problem.

    PubMed

    Cohen, B L

    1985-08-01

    It is widely believed that the I in soil is derived from the I in oceans by evaporating-atmospheric transport-washout by rain over land, rather than from the I in rock when the latter is weathered into soil. Since human I burdens are derived largely from soil by plant root uptake into food, this implies that the specific activity of 129I in the I of human thyroids will be the same as that in the oceans, whereas it would be similar to that in rock (much lower) if the I in soil were derived from weathering of rock as is the case for other heavy trace elements. The bases for the oceanic origin theory are analysed and found not to be in accord with modern data. Recent data shows no correlation between concentration of I in soil and proximity to oceans, which argues strongly against the oceanic origin theory. Some problems with long-distance atmospheric transport are pointed out. It is shown that the balance between I input to soil during soil formation by rock weathering and output from soil by erosion leaves little room for contributions from oceanic sources. It is concluded that only a small fraction of the I in soil is of oceanic origin. Most estimates of very long-term effects of 129I on human health are therefore several times too high.

  2. Live 129I-129Xe dating

    NASA Technical Reports Server (NTRS)

    Marti, K.

    1986-01-01

    A technique of cosmic ray exposure age dating using cosmic ray produced I-129 and Xe-129 components is discussed. The live I-129 - Xe-129 method provides an ideal monitor for cosmic ray flux variations on the 10(7)y - 10(8)y time-scale. It is based on low-energy neutron reactions on Te, and these data, when coupled to those from other methods, may facilitate the detection of complex exposure histories.

  3. Hawai'i: The Aloha State

    ERIC Educational Resources Information Center

    Klein, Edward F.

    2009-01-01

    August 21, 2009, marks the 50th anniversary of the entry of the 50th state into the United States of America. All the states have their stories, but as a string of islands in the vast Pacific Ocean, more than 2,000 miles from any other land mass, Hawai'i has a story that is unique in many ways. Consider, for example, that Hawai'i has two official…

  4. Enter the iPad (or Not?)

    ERIC Educational Resources Information Center

    Waters, John K.

    2010-01-01

    Few computing devices have sparked the burning gizmo lust ignited by the iPad. Apple's latest entry into the tablet PC market didn't generate much heat when it was first unveiled in January, but by April 3, the day of the official release, feverish customers were mobbing Apple stores. The company claims to have sold 300,000 iPads by midnight on…

  5. John Dewey's Visits to Hawai'i

    ERIC Educational Resources Information Center

    McEwan, Hunter

    2015-01-01

    John Dewey visited Hawai'i on three separate occasions. Of all three trips, by far the most important, as far as Dewey's influence on education in Hawai'i is concerned, was in 1899 when he came with his wife, Alice Chipman Dewey, to help launch the University Extension program in Honolulu. The Deweys' second trip was a very brief one--twenty years…

  6. IT Does Not Love iPads

    ERIC Educational Resources Information Center

    Fredette, Michelle

    2013-01-01

    On many campuses, iPads have taken over the hearts and minds of everyone. Everyone, that is, except the IT department. These sexy tablets might be the apple of faculty and students' eyes, but for IT directors and their staffs, working with iPads in an enterprise network environment is not the stuff of a love affair. To state the problem…

  7. NASA'S MSFC Welding Development for Ares I

    NASA Technical Reports Server (NTRS)

    Ding, Jeff

    2008-01-01

    This slide presentation reviews the development of welding for the Ares I launch vehicle. Shown are views of the Ares I and Ares 5, and comparisons with the space shuttle and Saturn V launch vehicles. The elements, and the contractor charged with developing each is shown. The various types of welding capabilities are reviewed. Pictures of the various welding systems available at Marshall Space Flight Center are shown.

  8. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  9. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  10. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  11. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  12. 49 CFR Appendix - Figures to Subpart I of Part 572

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... conditions. Pt. 572, Subpt. I, Figs. Figures to Subpart I of Part 572 Pt. 572, Subpt. I, Fig. 40 EC01AU91.169 Pt. 572, Subpt. I, Fig. 41 EC01AU91.170 Pt. 572, Subpt. I, Fig. 42 EC01AU91.171 Pt. 572, Subpt. I, Fig. 43 EC01AU91.172...

  13. Type I restriction enzymes and their relatives.

    PubMed

    Loenen, Wil A M; Dryden, David T F; Raleigh, Elisabeth A; Wilson, Geoffrey G

    2014-01-01

    Type I restriction enzymes (REases) are large pentameric proteins with separate restriction (R), methylation (M) and DNA sequence-recognition (S) subunits. They were the first REases to be discovered and purified, but unlike the enormously useful Type II REases, they have yet to find a place in the enzymatic toolbox of molecular biologists. Type I enzymes have been difficult to characterize, but this is changing as genome analysis reveals their genes, and methylome analysis reveals their recognition sequences. Several Type I REases have been studied in detail and what has been learned about them invites greater attention. In this article, we discuss aspects of the biochemistry, biology and regulation of Type I REases, and of the mechanisms that bacteriophages and plasmids have evolved to evade them. Type I REases have a remarkable ability to change sequence specificity by domain shuffling and rearrangements. We summarize the classic experiments and observations that led to this discovery, and we discuss how this ability depends on the modular organizations of the enzymes and of their S subunits. Finally, we describe examples of Type II restriction-modification systems that have features in common with Type I enzymes, with emphasis on the varied Type IIG enzymes.

  14. Type I interferon dysregulation and neurological disease.

    PubMed

    McGlasson, Sarah; Jury, Alexa; Jackson, Andrew; Hunt, David

    2015-09-01

    Type I interferon is an essential component of the brain's innate immune defence, conferring protection against viral infection. Recently, dysregulation of the type I interferon pathway has been implicated in the pathogenesis of a spectrum of neuroinfectious and neuroinflammatory disorders. Underactivity of the type I interferon response is associated with a predisposition to herpes simplex encephalitis. Conversely, a group of 'interferonopathic' disorders, characterized by severe neuroinflammation and overactivity of type I interferon, has been described. Elucidation of the genetic basis of these Mendelian neuroinflammatory diseases has uncovered important links between nucleic acid sensors, innate immune activation and neuroinflammatory disease. These mechanisms have an important role in the pathogenesis of more common polygenic diseases that can affect the brain, such as lupus and cerebral small vessel disease. In this article, we review the spectrum of neurological disease associated with type I interferon dysregulation, as well as advances in our understanding of the molecular and cellular pathogenesis of these conditions. We highlight the potential utility of type I interferon as both a biomarker and a therapeutic target in neuroinflammatory disease. PMID:26303851

  15. Fast CsI-phoswich detector

    DOEpatents

    Langenbrunner, James R.

    1996-01-01

    An improved phoswich radiation detector used pure CsI crystal and a fast plastic scintillator and a single photomultiplier tube. The plastic is arranged to receive incident radiation, and that which passed through then strikes the CsI crystal. Scintillation light from both the plastic and CsI crystal are applied to the photomultiplier tube, with the light from the plastic passing through the crystal without absorption therein. Electronics are provided for analyzing the output of the photomultiplier tube to discriminate responses due to the plastic and the CsI crystal, through short gate and long gate integration, to produce results which are indicative of the characteristics of the different types of incident radiation, even in the presence of large amounts of radiation. The phoswich detector has excellent timing resolution. The scintillators of the CsI- phoswich were chosen for their fast risetimes, of about 3 ns for NE102A, and 30 ns for the pure CsI.

  16. Fast CsI-phoswich detector

    DOEpatents

    Langenbrunner, J.R.

    1996-05-07

    An improved phoswich radiation detector used pure CsI crystal and a fast plastic scintillator and a single photomultiplier tube. The plastic is arranged to receive incident radiation, and that which passed through then strikes the CsI crystal. Scintillation light from both the plastic and CsI crystal are applied to the photomultiplier tube, with the light from the plastic passing through the crystal without absorption therein. Electronics are provided for analyzing the output of the photomultiplier tube to discriminate responses due to the plastic and the CsI crystal, through short gate and long gate integration, to produce results which are indicative of the characteristics of the different types of incident radiation, even in the presence of large amounts of radiation. The phoswich detector has excellent timing resolution. The scintillators of the CsI- phoswich were chosen for their fast risetimes, of about 3 ns for NE102A, and 30 ns for the pure CsI. 5 figs.

  17. Structure of a eukaryotic thiaminase I

    PubMed Central

    Kreinbring, Cheryl A.; Remillard, Stephen P.; Hubbard, Paul; Brodkin, Heather R.; Leeper, Finian J.; Hawksley, Dan; Lai, Elaine Y.; Fulton, Chandler; Petsko, Gregory A.; Ringe, Dagmar

    2014-01-01

    Thiaminases, enzymes that cleave vitamin B1, are sporadically distributed among prokaryotes and eukaryotes. Thiaminase I enzymes catalyze the elimination of the thiazole ring moiety from thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound. In eukaryotic organisms, these enzymes are reported to have much higher molecular weights than their bacterial counterparts. A thiaminase I of the single-celled amoeboflagellate Naegleria gruberi is the only eukaryotic thiaminase I to have been cloned, sequenced, and expressed. Here, we present the crystal structure of N. gruberi thiaminase I to a resolution of 2.8 Å, solved by isomorphous replacement and pseudo–two-wavelength multiwavelength anomalous diffraction and refined to an R factor of 0.231 (Rfree, 0.265). This structure was used to solve the structure of the enzyme in complex with 3-deazathiamin, a noncleavable thiamin analog and enzyme inhibitor (2.7 Å; R, 0.233; Rfree, 0.267). These structures define the mode of thiamin binding to this class of thiaminases and indicate the involvement of Asp272 as the catalytic base. This enzyme is able to use thiamin as a substrate and is active with amines such as aniline and veratrylamine as well as sulfhydryl compounds such as l-cysteine and β-mercaptoethanol as cosubstrates. Despite significant differences in polypeptide sequence and length, we have shown that the N. gruberi thiaminase I is homologous in structure and activity to a previously characterized bacterial thiaminase I. PMID:24351929

  18. Complex-I-ty in aging

    PubMed Central

    Stork, Devon A.

    2016-01-01

    The role of mitochondrial complex I in aging has been studied in both C. elegans and Drosophila, where RNAi knock down of specific complex I subunits has been shown to extend lifespan. More recently, studies in Drosophila have shown that an increase in mitochondrial activity, including complex I-like activity, can also slow aging. In this review, we discuss this apparent paradox. Improved maintenance of mitochondrial activity, mitochondrial homeostasis, may be responsible for lifespan extension in both cases. Decreased electron transport chain activity caused by reducing complex I subunit expression prompts an increase in stress response signaling that leads to enhanced mitochondrial homeostasis during aging. Increased complex I activity, as well as mitochondrial biogenesis, is expected to both directly counteract the decline in mitochondrial health that occurs during aging and may also increase cellular NAD+ levels, which have been linked to mitochondrial homeostatic mechanisms through activation of sirtuins. We suggest that manipulations that increase or decrease complex I activity both converge on improved mitochondrial homeostasis during aging, resulting in prolonged lifespan. PMID:24961226

  19. Structure of a eukaryotic thiaminase I.

    PubMed

    Kreinbring, Cheryl A; Remillard, Stephen P; Hubbard, Paul; Brodkin, Heather R; Leeper, Finian J; Hawksley, Dan; Lai, Elaine Y; Fulton, Chandler; Petsko, Gregory A; Ringe, Dagmar

    2014-01-01

    Thiaminases, enzymes that cleave vitamin B1, are sporadically distributed among prokaryotes and eukaryotes. Thiaminase I enzymes catalyze the elimination of the thiazole ring moiety from thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound. In eukaryotic organisms, these enzymes are reported to have much higher molecular weights than their bacterial counterparts. A thiaminase I of the single-celled amoeboflagellate Naegleria gruberi is the only eukaryotic thiaminase I to have been cloned, sequenced, and expressed. Here, we present the crystal structure of N. gruberi thiaminase I to a resolution of 2.8 Å, solved by isomorphous replacement and pseudo-two-wavelength multiwavelength anomalous diffraction and refined to an R factor of 0.231 (Rfree, 0.265). This structure was used to solve the structure of the enzyme in complex with 3-deazathiamin, a noncleavable thiamin analog and enzyme inhibitor (2.7 Å; R, 0.233; Rfree, 0.267). These structures define the mode of thiamin binding to this class of thiaminases and indicate the involvement of Asp272 as the catalytic base. This enzyme is able to use thiamin as a substrate and is active with amines such as aniline and veratrylamine as well as sulfhydryl compounds such as l-cysteine and β-mercaptoethanol as cosubstrates. Despite significant differences in polypeptide sequence and length, we have shown that the N. gruberi thiaminase I is homologous in structure and activity to a previously characterized bacterial thiaminase I.

  20. 31 CFR 359.35 - May I purchase definitive Series I savings bonds through a payroll savings plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false May I purchase definitive Series I... PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.35 May I purchase definitive Series I savings bonds through a payroll savings plan? You may...

  1. 31 CFR 359.36 - May I purchase definitive Series I savings bonds through employee thrift, savings, vacation, and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false May I purchase definitive Series I... OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.36 May I purchase definitive Series I savings bonds through...

  2. 31 CFR 359.35 - May I purchase definitive Series I savings bonds through a payroll savings plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false May I purchase definitive Series I... PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.35 May I purchase definitive Series I savings bonds through a payroll savings plan? Treasury...

  3. 31 CFR 359.34 - May I purchase definitive Series I savings bonds over-the-counter?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false May I purchase definitive Series I... OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.34 May I purchase definitive Series I savings bonds over-the-counter? You may purchase definitive bonds...

  4. 31 CFR 359.36 - May I purchase definitive Series I savings bonds through employee thrift, savings, vacation, and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false May I purchase definitive Series I... OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.36 May I purchase definitive Series I savings bonds through...

  5. 31 CFR 359.34 - May I purchase definitive Series I savings bonds over-the-counter?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false May I purchase definitive Series I... OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.34 May I purchase definitive Series I savings bonds over-the-counter? You may purchase definitive bonds...

  6. Differential requirement for <i>irf>8 in formation of embryonic and adult macrophages in zebrafish

    SciTech Connect

    Shiau, Celia E.; Kaufman, Zoe; Meireles, Ana M.; Talbot, William S.

    2015-01-23

    Interferon regulatory factor 8 (Irf8) is critical for mammalian macrophage development and innate immunity, but its role in teleost myelopoiesis remains incompletely understood. Specifically, genetic tools to analyze the role of <i>irf>8 in zebrafish macrophage development at larval and adult stages are lacking. In this study, we generated <i>irf>8 null mutants in zebrafish using TALEN-mediated targeting. Our analysis defines different requirements for <i>irf>8 at different stages. <i>irf>8 is required for formation of all macrophages during primitive and transient definitive hematopoiesis, but not during adult-phase definitive hematopoiesis starting at 5-6 days postfertilization. At early stages, <i>irf>8 mutants have excess neutrophils and excess cell death in pu.1-expressing myeloid cells. Macrophage fates were recovered in <i>irf>8 mutants after wildtype <i>irf>8 expression in neutrophil and macrophage lineages, suggesting that <i>irf>8 regulates macrophage specification and survival. In juvenile <i>irf>8 mutant fish, mature macrophages are present, but at numbers significantly reduced compared to wildtype, indicating an ongoing requirement for <i>irf>8 after embryogenesis. As development progresses, tissue macrophages become apparent in zebrafish <i>irf>8 mutants, with the possible exception of microglia. Our study defines distinct requirement for <i>irf>8 in myelopoiesis before and after transition to the adult hematopoietic system.

  7. 30 CFR 57.22222 - Ventilation materials (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Ventilation materials (I-A, I-B, I-C, II-A, III....22222 Ventilation materials (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). Brattice cloth and ventilation tubing shall be approved by MSHA in accordance with 30 CFR part 7, or shall bear a BC or...

  8. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on...

  9. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on...

  10. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on...

  11. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reverse airstream shall be approved by MSHA under the appliable requirements of 30 CFR part 18; (2) Drive... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on...

  12. Nutrient requirements and growth physiology of the photoheterotrophic Acidobacterium, <i>Chloracidobacterium thermophilumi>

    SciTech Connect

    Tank, Marcus; Bryant, Donald A.

    2015-03-27

    A novel thermophilic, microaerophilic, anoxygenic, and chlorophototrophic member of the phylum <i>Acidobacteria, Chloracidobacterium thermophilumi> strain BT, was isolated from a cyanobacterial enrichment culture derived from microbial mats associated with Octopus Spring, Yellowstone National Park, Wyoming. <i>C. thermophilumi> is strictly dependent on light and oxygen and grows optimally as a photoheterotroph at irradiance values between 20 and 50 µmol photons m⁻² s⁻¹. <i>C. thermophilumi> is unable to synthesize branched-chain amino acids (AAs), L-lysine, and vitamin B₁₂, which are required for growth. Although the organism lacks genes for autotrophic carbon fixation, bicarbonate is also required. Mixtures of other AAs and 2-oxoglutarate stimulate growth. As suggested from genomic sequence data, <i>C. thermophilumi> requires a reduced sulfur source such as thioglycolate, cysteine, methionine, or thiosulfate. The organism can be grown in a defined medium at 51° C (Topt; range 44–58°C) in the pH range 5.5–9.5 (pHopt = ~7.0). Using the defined growth medium and optimal conditions, it was possible to isolate new <i>C. thermophilumi> strains directly from samples of hot springs mats in Yellowstone National Park, Wyoming. The new isolates differ from the type strain with respect to pigment composition, morphology in liquid culture, and temperature adaptation.

  13. Density- and wavefunction-normalized Cartesian spherical harmonics for <i>l> ≤ 20

    SciTech Connect

    Michael, J. Robert; Volkov, Anatoliy

    2015-03-01

    The widely used pseudoatom formalism in experimental X-ray charge-density studies makes use of real spherical harmonics when describing the angular component of aspherical deformations of the atomic electron density in molecules and crystals. The analytical form of the density-normalized Cartesian spherical harmonic functions for up to <i>l> ≤ 7 and the corresponding normalization coefficients were reported previously by Paturle & Coppens. It was shown that the analytical form for normalization coefficients is available primarily forl ≤ 4. Only in very special cases it is possible to derive an analytical representation of the normalization coefficients for 4 < <i>l> ≤ 7. In most cases for <i>l> > 4 the density normalization coefficients were calculated numerically to within seven significant figures. In this study we review the literature on the density-normalized spherical harmonics, clarify the existing notations, use the Paturle–Coppens method in the Wolfram <i>Mathematica>software to derive the Cartesian spherical harmonics for <i>l> ≤ 20 and determine the density normalization coefficients to 35 significant figures, and computer-generate a Fortran90 code. The article primarily targets researchers who work in the field of experimental X-ray electron density, but may be of some use to all who are interested in Cartesian spherical harmonics.

  14. Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes.

    PubMed

    Cavicchioli, Maurício; Leite, Clarice Q F; Sato, Daisy N; Massabni, Antonio C

    2007-10-01

    The present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 microM for Ag(I)-aspartame against M. kansasii and 15.7 microM for Ag(I)-cyclamate against M. tuberculosis.

  15. Density sensitive X-ray line ratios in the Be I, B I, and Ne I isoelectronic sequences

    NASA Technical Reports Server (NTRS)

    Feldman, U.; Seely, J. F.; Bhatia, A. K.

    1985-01-01

    The intensities of X-ray transitions in highly charged ions in the Be I, B I, and Ne I isoelectronic sequences have been calculated as functions of electron density. The intensities of the transitions from the 2s(n)2p(m)3p configuration, relative to the intensities from the 2s(n)2p(m)3s and 2s(n)p(m)3d configurations, are strong functions of electron density in high-density plasmas. The density sensitivity occurs at electron densities between 10 to the 16th/cu cm (for Si ions) and 10 to the 22nd/cu cm (for Kr ions). Opacity is unimportant for plasma dimensions that are characteristic of dense laser-produced plasmas. These X-ray line ratios represent a promising new density diagnostic for high-density plasmas.

  16. H I in Group Interactions: HCG 44

    NASA Astrophysics Data System (ADS)

    Hess, Kelley M.; Cluver, M. E.; Yahya, Sahba; Leisman, Lukas; Serra, Paolo; Lucero, Danielle M.; Passmoor, Sean S.; Carignan, Claude

    2016-09-01

    Extending deep observations of the neutral atomic hydrogen (H I) to the environment around galaxy groups can reveal a complex history of group interactions which is invisible to studies that focus on the stellar component. Hickson Compact Group 44 (HCG 44) is a nearby example and we have combined H I data from the Karoo Array Telescope, Westerbork Synthesis Radio Telescope, and Arecibo Legacy Fast ALFA survey, in order to achieve high column density sensitivity (NHI < 2 × 1018 cm-2) to the neutral gas over a large field-of-view beyond the compact group itself. We find the giant H I tail north of HCG 44 contains 1.1 × 109 M⊙ of gas and extends 450 kpc from the compact group: twice as much mass and 33% further than previously detected. However, the additional gas is still unable to account for the known H I deficiency of HCG 44. The tail likely formed through a strong tidal interaction and H I clouds in the tail have survived for 1 Gyr or more after being stripped. This has important implications for understanding the survival of neutral clouds in the intragroup and circumgroup medium, and we discuss their survival in the context of simulations of cold gas in hot halos. HCG 44 is one of a growing number of galaxy groups found to have more extended H I in the intragroup and circumgroup medium than previously measured. Our results provide constraints for simulations on the properties of galaxy group halos, and reveal a glimpse of what will be seen by future powerful H I telescopes and surveys.

  17. Groundbased IO [O I] 6300A Observations during the Galileo I24 and I25 and Cassini Encounters

    NASA Technical Reports Server (NTRS)

    Oliverson, R. J.; Morgenthaler, J. P.; Scherb, F.; Harris, W. M.; Smyth, W. H.; Lupie, O. L.; Oegerle, William R. (Technical Monitor)

    2002-01-01

    We report on selected recent spectroscopic observations of Io [OI] 6300Angstrom emission, using the high-resolution (R approximately equal to 120,000) stellar spectrograph at the National Solar Observatory McMath-Pierce telescope. These data were obtained during the Galileo I24 (1999-Oct-11) and I25 (1999-Nov-26) encounters with Io and the Cassini Jupiter encounter (closest approach 2000-Dec-30). The exposure time for each spectrum was 15 minutes, with a 5.2 second x 5.2 second aperture centered on Io. We obtained 102 spectra for the I24 encounter during 1999 October 9-13, 82 spectra for the I25 encounter during 1999 November 24-28, 313 spectra during 2000 December 11-23, and 280 spectra during 2000 December 29-2001 January 21 for the Cassini Jupiter encounter. We showed in a recent paper (Oliversen et al. 2001, JGR, 106, 26183) that this emission allows us to use Io as a localized probe of the three-dimensional plasma torus structure. We will also present preliminary results on selected contemporaneous narrowband [SII]6731A torus images obtained at the McMath-Pierce west auxiliary telescope. We took 136, 112, and 277 torus images during the Galileo I24, Galileo I25 and Cassini Jupiter encounters, respectively. Jupiter was imaged directly onto the CCD through a ND 4 filter and the reflected light was used for guiding. Both sides of the torus were imaged simultaneously when there were no Galilean satellites between 3-8 Jovian radii from Jupiter.

  18. Cold H I in faint dwarf galaxies

    NASA Astrophysics Data System (ADS)

    Patra, Narendra Nath; Chengalur, Jayaram N.; Karachentsev, Igor D.; Kaisin, Serafim S.; Begum, Ayesha

    2016-03-01

    We present the results of a study of the amount and distribution of cold atomic gas, as well its correlation with recent star formation in a sample of extremely faint dwarf irregular galaxies. Our sample is drawn from the Faint Irregular Galaxy GMRT Survey (FIGGS) and its extension, FIGGS2. We use two different methods to identify cold atomic gas. In the first method, line-of-sight H I spectra were decomposed into multiple Gaussian components and narrow Gaussian components were identified as cold H I. In the second method, the brightness temperature (TB ) is used as a tracer of cold H I. We find that the amount of cold gas identified using the TB method is significantly larger than the amount of gas identified using Gaussian decomposition. We also find that a large fraction of the cold gas identified using the TB method is spatially coincident with regions of recent star formation, although the converse is not true. That is only a small fraction of the regions with recent star formation are also covered by cold gas. For regions where the star formation and the cold gas overlap, we study the relationship between the star formation rate density and the cold H I column density. We find that the star formation rate density has a power-law dependence on the H I column density, but that the slope of this power law is significantly flatter than that of the canonical Kennicutt-Schmidt relation.

  19. Induction of Type I Interferons by Bacteria

    PubMed Central

    Monroe, Kathryn M.; McWhirter, Sarah M.; Vance, Russell E.

    2010-01-01

    SUMMARY Type I interferons (IFNs) are secreted cytokines that orchestrate diverse immune responses to infection. Although typically considered to be most important in the response to viruses, type I IFNs are also induced by most, if not all, bacterial pathogens. Although diverse mechanisms have been described, bacterial induction of type I IFNs occurs upon stimulation of two main pathways: (1) Toll-like receptor (TLR) recognition of bacterial molecules such as lipopolysaccharide (LPS); (2) TLR-independent recognition of molecules delivered to the host cell cytosol. Cytosolic responses can be activated by two general mechanisms. First, viable bacteria can secrete stimulatory ligands into the cytosol via specialized bacterial secretion systems. Second, ligands can be released from bacteria that lyse or are degraded. The bacterial ligands that induce the cytosolic pathways remains uncertain in many cases, but appear to include various nucleic acids. In this review, we discuss recent advances in our understanding of how bacteria induce type I interferons and the roles type I IFNs play in host immunity. PMID:20482555

  20. Structure of mammalian respiratory complex I.

    PubMed

    Zhu, Jiapeng; Vinothkumar, Kutti R; Hirst, Judy

    2016-08-18

    Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the cell, powers ATP synthesis in mammalian mitochondria by using the reducing potential of NADH to drive protons across the inner mitochondrial membrane. Mammalian complex I (ref. 1) contains 45 subunits, comprising 14 core subunits that house the catalytic machinery (and are conserved from bacteria to humans) and a mammalian-specific cohort of 31 supernumerary subunits. Knowledge of the structures and functions of the supernumerary subunits is fragmentary. Here we describe a 4.2-Å resolution single-particle electron cryomicroscopy structure of complex I from Bos taurus. We have located and modelled all 45 subunits, including the 31 supernumerary subunits, to provide the entire structure of the mammalian complex. Computational sorting of the particles identified different structural classes, related by subtle domain movements, which reveal conformationally dynamic regions and match biochemical descriptions of the 'active-to-de-active' enzyme transition that occurs during hypoxia. Our structures therefore provide a foundation for understanding complex I assembly and the effects of mutations that cause clinically relevant complex I dysfunctions, give insights into the structural and functional roles of the supernumerary subunits and reveal new information on the mechanism and regulation of catalysis. PMID:27509854

  1. Structure of bacterial respiratory complex I.

    PubMed

    Berrisford, John M; Baradaran, Rozbeh; Sazanov, Leonid A

    2016-07-01

    Complex I (NADH:ubiquinone oxidoreductase) plays a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation. It is the largest protein assembly of respiratory chains and one of the most elaborate redox membrane proteins known. Bacterial enzyme is about half the size of mitochondrial and thus provides its important "minimal" model. Dysfunction of mitochondrial complex I is implicated in many human neurodegenerative diseases. The L-shaped complex consists of a hydrophilic arm, where electron transfer occurs, and a membrane arm, where proton translocation takes place. We have solved the crystal structures of the hydrophilic domain of complex I from Thermus thermophilus, the membrane domain from Escherichia coli and recently of the intact, entire complex I from T. thermophilus (536 kDa, 16 subunits, 9 iron-sulphur clusters, 64 transmembrane helices). The 95Å long electron transfer pathway through the enzyme proceeds from the primary electron acceptor flavin mononucleotide through seven conserved Fe-S clusters to the unusual elongated quinone-binding site at the interface with the membrane domain. Four putative proton translocation channels are found in the membrane domain, all linked by the central flexible axis containing charged residues. The redox energy of electron transfer is coupled to proton translocation by the as yet undefined mechanism proposed to involve long-range conformational changes. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt.

  2. The natural history of group I introns.

    PubMed

    Haugen, Peik; Simon, Dawn M; Bhattacharya, Debashish

    2005-02-01

    There are four major classes of introns: self-splicing group I and group II introns, tRNA and/or archaeal introns and spliceosomal introns in nuclear pre-mRNA. Group I introns are widely distributed in protists, bacteria and bacteriophages. Group II introns are found in fungal and land plant mitochondria, algal plastids, bacteria and Archaea. Group II and spliceosomal introns share a common splicing pathway and might be related to each other. The tRNA and/or archaeal introns are found in the nuclear tRNA of eukaryotes and in archaeal tRNA, rRNA and mRNA. The mechanisms underlying the self-splicing and mobility of a few model group I introns are well understood. By contrast, the role of these highly distinct processes in the evolution of the 1500 group I introns found thus far in nature (e.g. in algae and fungi) has only recently been clarified. The explosion of new sequence data has facilitated the use of comparative methods to understand group I intron evolution in a broader context and to generate hypotheses about intron insertion, splicing and spread that can be tested experimentally.

  3. GLOBAL H I KINEMATICS IN DWARF GALAXIES

    SciTech Connect

    Stilp, Adrienne M.; Dalcanton, Julianne J.; Warren, Steven R.; Skillman, Evan; Ott, Juergen; Koribalski, Baerbel

    2013-03-10

    H I line widths are typically interpreted as a measure of interstellar medium turbulence, which is potentially driven by star formation (SF). In an effort to better understand the possible connections between line widths and SF, we have characterized H I kinematics in a sample of nearby dwarf galaxies by co-adding line-of-sight spectra after removing the rotational velocity to produce average global H I line profiles. These ''superprofiles'' are composed of a central narrow peak ({approx}6-10 km s{sup -1}) with higher-velocity wings to either side that contain {approx}10%-15% of the total flux. The superprofiles are all very similar, indicating a universal global H I profile for dwarf galaxies. We compare characteristics of the superprofiles to various galaxy properties, such as mass and measures of SF, with the assumption that the superprofile represents a turbulent peak with energetic wings to either side. We use these quantities to derive average scale heights for the sample galaxies. When comparing to physical properties, we find that the velocity dispersion of the central peak is correlated with ({Sigma}{sub HI}). The fraction of mass and characteristic velocity of the high-velocity wings are correlated with measures of SF, consistent with the picture that SF drives surrounding H I to higher velocities. While gravitational instabilities provide too little energy, the SF in the sample galaxies does provide enough energy through supernovae, with realistic estimates of the coupling efficiency, to produce the observed superprofiles.

  4. Piliwaiwai: Problem Gambling in Hawai'i.

    PubMed

    Shepherd, Robin-Marie

    2016-03-01

    Gambling is illegal in Hawai'i, but it is accessible through technology (eg, the internet), inexpensive trips to Las Vegas, and illegal gaming such as lottery sales, internet gambling, and sports betting. Where there are opportunities to gamble, there is a probability that problem gambling exists. The social costs of gambling are estimated to be as high as $26,300,000 for Hawai'i. Because no peer-reviewed research on this topic exists, this paper has gathered together anecdotal accounts and media reports of illegal gambling in Hawai'i, the existence of Gamblers Anonymous meetings operating on some of the islands, and an account of workshops on problem gambling that were provided by the author on three Hawaiian Islands. Through these lenses of gambling in Hawai'i, it is suggested that there are residents in Hawai'i who do experience problem gambling, yet it is unknown to what extent. Nonetheless, this paper argues that research and perhaps a public health initiative are warranted. PMID:27011888

  5. Modeling fallout of anthropogenic 129I.

    PubMed

    Englund, Edvard; Aldahan, Ala; Possnert, Göran; Haltia-Hovi, Eeva; Hou, Xiaolin; Renberg, Ingmar; Saarinen, Timo

    2008-12-15

    Despite the relatively well-recognized emission rates of the anthropogenic 129I, there is little knowledge about the temporal fallout patterns and magnitude of fluxes since the start of the atomic era atthe early 1940s. We here present measurements of annual 129I concentrations in sediment archives from Sweden and Finland covering the period 1942-2006. The results revealed impression of 129I emissions from the nuclear reprocessing facility at Sellafield and La Hague and a clear Chernobyl fallout enhancement during 1986. In order to estimate relative contributions from the different sources, a numerical model approach was used taking into accountthe emission rates/estimated fallout, transport pathways, and the sediment system. The model outcomes suggest a relatively dominating marine source of 129I to north Europe compared to direct gaseous releases. A transfer rate of 129I from sea to atmosphere is derived for pertinent sea areas (English Channel, Irish Sea, and North Sea), which is estimated at 0.04 to 0.21 y(-1).

  6. Piliwaiwai: Problem Gambling in Hawai‘i

    PubMed Central

    2016-01-01

    Gambling is illegal in Hawai‘i, but it is accessible through technology (eg, the internet), inexpensive trips to Las Vegas, and illegal gaming such as lottery sales, internet gambling, and sports betting. Where there are opportunities to gamble, there is a probability that problem gambling exists. The social costs of gambling are estimated to be as high as $26,300,000 for Hawai‘i. Because no peer-reviewed research on this topic exists, this paper has gathered together anecdotal accounts and media reports of illegal gambling in Hawai‘i, the existence of Gamblers Anonymous meetings operating on some of the islands, and an account of workshops on problem gambling that were provided by the author on three Hawaiian Islands. Through these lenses of gambling in Hawai‘i, it is suggested that there are residents in Hawai‘i who do experience problem gambling, yet it is unknown to what extent. Nonetheless, this paper argues that research and perhaps a public health initiative are warranted. PMID:27011888

  7. Salt and gene expression: evidence for [Na+]i/[K+]i-mediated signaling pathways.

    PubMed

    Orlov, Sergei N; Hamet, Pavel

    2015-03-01

    Our review focuses on the recent data showing that gene transcription and translation are under the control of signaling pathways triggered by modulation of the intracellular sodium/potassium ratio ([Na+]i/[K+]i). Side-by-side with sensing of osmolality elevation by tonicity enhancer-binding protein (TonEBP, NFAT5), [Na+]i/[K+]i-mediated excitation-transcription coupling may contribute to the transcriptomic changes evoked by high salt consumption. This novel mechanism includes the sensing of heightened Na+ concentration in the plasma, interstitial, and cerebrospinal fluids via augmented Na+ influx in the endothelium, immune system cells, and the subfornical organ, respectively. In these cells, [Na+]i/[K+]i ratio elevation, triggered by augmented Na+ influx, is further potentiated by increased production of endogenous Na+,K+-ATPase inhibitors documented in salt-sensitive hypertension. PMID:25479826

  8. Crystallization kinetics of {alpha}-AgI in AgI-based silver orthoborate glasses

    SciTech Connect

    Taniguchi, Akihiro; Tatsumisago, Masahiro; Minami, Tsutomu

    1995-02-01

    Kinetics for nucleation and growth of {alpha}-AgI crystals in AgI-based silver orthoborate glasses, in which only {alpha}-AgI crystals were found to crystallize in the heating process of the glasses, were studied by isothermal and nonisothermal measurements using differential scanning calorimetry and by observations of the microstructure of the glasses using scanning electron microscopy. The values of both n and m, dependent on the crystallization mechanism, were found to be 3, indicating that a constant number of nuclei of {alpha}-AgI precipitated in a glass matrix grew three-dimensionally. The preannealing of the glasses at temperatures between glass transition and crystallization did not affect the DSC isothermal curves in the crystal growth process, which suggested that the number of {alpha}-AgI nuclei would have been saturated in the glass when the glasses were prepared by quenching the AgI-based melts.

  9. "I Have an iPad. Now What?" Using Mobile Devices in University Physical Education Programs

    ERIC Educational Resources Information Center

    Rosenthal, Maura B.; Eliason, Susan K.

    2015-01-01

    In response to an iPad initiative at a mid-sized New England university, all faculty, junior and senior undergraduates, and graduate students were required to have iPads by the first day of class in the fall semester of 2013. Goals of the initiative focused on preparing future teachers to use the iPad as a teaching and learning tool so they could…

  10. Human T-cell leukemia virus types I and II exhibit different DNase I protection patterns.

    PubMed

    Altman, R; Harrich, D; Garcia, J A; Gaynor, R B

    1988-04-01

    Human T-cell leukemia virus types I (HTLV-I) and II (HTLV-II) are human retroviruses which normally infect T-lymphoid cells. HTLV-I infection is associated with adult T-cell leukemia-lymphoma, and HTLV-II is associated with an indolent form of hairy-cell leukemia. To identify potential transcriptional regulatory elements of these two related human retroviruses, we performed DNase I footprinting of both the HTLV-I and HTLV-II long terminal repeats (LTRs) by using extracts prepared from uninfected T cells, HTLV-I and HTLV-II transformed T cells, and HeLa cells. Five regions of the HTLV-I LTR and three regions of the HTLV-II LTR showed protection by DNase I footprinting. All three of the 21-base-pair repeats previously shown to be important in HTLV transcriptional regulation were protected in the HTLV-I LTR, whereas only one of these repeats was protected in the HTLV-II LTR. Several regions exhibited altered protection in extracts prepared from lymphoid cells as compared with HeLa cells, but there were minimal differences in the protection patterns between HTLV-infected and uninfected lymphoid extracts. A number of HTLV-I and HTLV-II LTR fragments which contained regions showing protection in DNase I footprinting were able to function as inducible enhancer elements in transient CAT gene expression assays in the presence of the HTLV-II tat protein. The alterations in the pattern of the cellular proteins which bind to the HTLV-I and HTLV-II LTRs may in part be responsible for differences in the transcriptional regulation of these two related viruses.

  11. I-Xe systematics in LL chondrites

    NASA Technical Reports Server (NTRS)

    Bernatowicz, T. J.; Podosek, F. A.; Swindle, T. D.; Honda, M.

    1988-01-01

    A stepwise heating analysis of Ar and Xe data from five neutron-irradiated whole rock LL chondrites (Soko Banja, Alta Ameen, Tuxtuac, Guidder, and Olivenza) is presented, emphasizing the complicated thermal history of ordinary chondrites. None of the present meteorites show a well-defined (Ar-40)-(Ar-39) apparent age plateau comprised of more than two release fractions. Most of the samples are found to yield well-defined high-temperature correlations between Xe-129/Xe-130 and Xe-128/Xe-130, and thus determinations of I-129/I-127 and Xe-129/Xe-130 at the time of isotopic closure for Xe. As in the case of other ordinary chondrites, the I-Xe systematics for LL chondrites correlate neither with a metamorphic grade nor with chronologies based opon other methods.

  12. The Hitchhiker's Guide to I&T

    NASA Technical Reports Server (NTRS)

    Wright, Michael R.

    1999-01-01

    With over two dozen missions since the first in 1986, the Hitchhiker project has a reputation for providing quick-reaction, low-cost flight services for Shuttle Small Payloads Project (SSPP) customers. Despite the successes, several potential improvements in customer payload integration and test (I&T) deserve consideration. This paper presents suggestions to Hitchhiker customers on how to help make the I&T process run smoother. Included are: customer requirements and interface definition, pre-integration test and evaluation, configuration management, I&T overview and planning, problem mitigation, and organizational communication. In this era of limited flight opportunities and new ISO-based requirements, issues such as these have become more important than ever.

  13. The MHC class I genes of zebrafish.

    PubMed

    Dirscherl, Hayley; McConnell, Sean C; Yoder, Jeffrey A; de Jong, Jill L O

    2014-09-01

    Major histocompatibility complex (MHC) molecules play a central role in the immune response and in the recognition of non-self. Found in all jawed vertebrate species, including zebrafish and other teleosts, MHC genes are considered the most polymorphic of all genes. In this review we focus on the multi-faceted diversity of zebrafish MHC class I genes, which are classified into three sequence lineages: U, Z, and L. We examine the polygenic, polymorphic, and haplotypic diversity of the zebrafish MHC class I genes, discussing known and postulated functional differences between the different class I lineages. In addition, we provide the first comprehensive nomenclature for the L lineage genes in zebrafish, encompassing at least 15 genes, and characterize their sequence properties. Finally, we discuss how recent findings have shed new light on the remarkably diverse MHC loci of this species.

  14. Hot, Massive Stars in I Zw 18

    NASA Technical Reports Server (NTRS)

    Heap, Sara R.; Lindler, D.; Malumuth, E.

    2011-01-01

    I Zw 18 is one of the most primitive blue, compact dwarf galaxies. The ionized gas in I Zw 18 has a low oxygen abundance (O approx.1/30 Osun) and nitrogen abundance (N-1/100 Nsun) (Pequignot 2008). We have obtained a far-UV spectrum of the northwest massive star cluster of I Zw 18 using Hubble's Cosmic Origins Spectrograph (COS). The spectrum is compatible with continuous star-formation over the past approx.10 Myr, and a very low metallicity, log Z/Zsun 1.7, although the stellar surface may be enhanced in carbon. Stellar wind lines are very weak, and the edge velocity of wind lines is very low (approx.250 km/s).

  15. Redetermination of Hg2I2

    PubMed Central

    Kars, Mohammed; Roisnel, Thierry; Dorcet, Vincent; Rebbah, Allaoua; L. Carlos, Otero-Diáz

    2012-01-01

    The crystal structure of mercurous iodide, Hg2I2, has been determined previously from X-ray powder diffraction data [Havighurst (1926 ▶). J. Am. Chem. Soc. 48, 2113–2125]. The results of the current redetermination based on single-crystal X-ray diffraction data provide more precise geometrical data and also anisotropic displacement parameters for the Hg and I atoms, which are both situated on positions with site-symmetry 4mm. The structure consists of linear dimers I—Hg—Hg—I extending along the c axis with an Hg—Hg distance of 2.5903 (13) Å. The overall coordination sphere of the Hg+ atom is a considerably distorted octa­hedron. The crystal specimen under investigation was twinned by non-merohedry with a refined twin domain fraction of 0.853 (14):0.147 (14). PMID:22346788

  16. Initial Ares I Bending Filter Design

    NASA Technical Reports Server (NTRS)

    Jang, Jiann-Woei; Bedrossian, Nazareth; Hall, Robert; Norris, H. Lee; Hall, Charles; Jackson, Mark

    2007-01-01

    The Ares-I launch vehicle represents a challenging flex-body structural environment for control system design. Software filtering of the inertial sensor output will be required to ensure control system stability and adequate performance. This paper presents a design methodology employing numerical optimization to develop the Ares-I bending filters. The filter design methodology was based on a numerical constrained optimization approach to maximize stability margins while meeting performance requirements. The resulting bending filter designs achieved stability by adding lag to the first structural frequency and hence phase stabilizing the first Ares-I flex mode. To minimize rigid body performance impacts, a priority was placed via constraints in the optimization algorithm to minimize bandwidth decrease with the addition of the bending filters. The bending filters provided here have been demonstrated to provide a stable first stage control system in both the frequency domain and the MSFC MAVERIC time domain simulation.

  17. Atmospheric methyl iodide /CH3I/

    NASA Technical Reports Server (NTRS)

    Rasmussen, R. A.; Khalil, M. A. K.; Gunawardena, R.; Hoyt, S. D.

    1982-01-01

    It is found that atmospheric concentrations of CH3I are not greater than about 3 pptv over most of the earth's surface and drop to less than half this value above the boundary layer, suggesting that the compound is not likely to play such important roles, on a global scale, as the destruction of tropospheric O3 and free radicals and the increasing of the NO2/NO ratio and hydroxyl radical densities. It is hypothesized that a large portion of the global CH3I comes from oceanic regions of high biomass productivity, where the compound may play a key role in local atmospheric chemistry. Attention is given to CH3I measurement uncertainties with regard to global distribution, sources, and sinks.

  18. iSIGHT-FD scalability test report.

    SciTech Connect

    Clay, Robert L.; Shneider, Max S.

    2008-07-01

    The engineering analysis community at Sandia National Laboratories uses a number of internal and commercial software codes and tools, including mesh generators, preprocessors, mesh manipulators, simulation codes, post-processors, and visualization packages. We define an analysis workflow as the execution of an ordered, logical sequence of these tools. Various forms of analysis (and in particular, methodologies that use multiple function evaluations or samples) involve executing parameterized variations of these workflows. As part of the DART project, we are evaluating various commercial workflow management systems, including iSIGHT-FD from Engineous. This report documents the results of a scalability test that was driven by DAKOTA and conducted on a parallel computer (Thunderbird). The purpose of this experiment was to examine the suitability and performance of iSIGHT-FD for large-scale, parameterized analysis workflows. As the results indicate, we found iSIGHT-FD to be suitable for this type of application.

  19. Nuclear Concrete Materials Database Phase I Development

    SciTech Connect

    Ren, Weiju; Naus, Dan J

    2012-05-01

    The FY 2011 accomplishments in Phase I development of the Nuclear Concrete Materials Database to support the Light Water Reactor Sustainability Program are summarized. The database has been developed using the ORNL materials database infrastructure established for the Gen IV Materials Handbook to achieve cost reduction and development efficiency. In this Phase I development, the database has been successfully designed and constructed to manage documents in the Portable Document Format generated from the Structural Materials Handbook that contains nuclear concrete materials data and related information. The completion of the Phase I database has established a solid foundation for Phase II development, in which a digital database will be designed and constructed to manage nuclear concrete materials data in various digitized formats to facilitate electronic and mathematical processing for analysis, modeling, and design applications.

  20. <i>Clostridium thermocellumi> DSM 1313 transcriptional responses to redox perturbation

    SciTech Connect

    Sander, Kyle B.; Wilson, Charlotte M.; M. Rodriquez, Jr.; Klingeman, Dawn Marie; Davison, Brian H.; Brown, Steven D.; Rydzak, T.

    2015-12-12

    <i>Clostridium thermocellumi> is a promising consolidated bioprocessing candidate organism capable of directly converting lignocellulosic biomass to ethanol. Current ethanol yields, productivities, and growth inhibitions are industrial deployment impediments for commodity fuel production by this bacterium. Redox imbalance under certain conditions and in engineered strains may contribute to incomplete substrate utilization and may direct fermentation products to undesirable overflow metabolites. As a result, towards a better understanding of redox metabolism in <i>C. thermocellumi>, we established continuous growth conditions and analyzed global gene expression during addition of two stress chemicals (methyl viologen and hydrogen peroxide) which changed the fermentation redox potential.

  1. iSpike: a spiking neural interface for the iCub robot.

    PubMed

    Gamez, D; Fidjeland, A K; Lazdins, E

    2012-06-01

    This paper presents iSpike: a C++ library that interfaces between spiking neural network simulators and the iCub humanoid robot. It uses a biologically inspired approach to convert the robot's sensory information into spikes that are passed to the neural network simulator, and it decodes output spikes from the network into motor signals that are sent to control the robot. Applications of iSpike range from embodied models of the brain to the development of intelligent robots using biologically inspired spiking neural networks. iSpike is an open source library that is available for free download under the terms of the GPL. PMID:22617339

  2. iPhones, iPads, and medical applications for antimicrobial stewardship.

    PubMed

    Goff, Debra A

    2012-07-01

    One of the most important antimicrobial stewardship activities of the infectious diseases pharmacist and physician is to provide education and clinical information about antimicrobials to health care professionals and patients; however, clinician training and continuing education in appropriate antimicrobial use in the United States are highly variable and nonstandardized. The iPhone, iPad, and the availability of more than 12,000 medical applications (referred to as "apps") allow stewardship programs the ability to integrate novel technology with point-of-care education. This article reviews medical apps for antimicrobial stewardship programs to use on the iPhone or iPad. PMID:22605544

  3. Human conditions of insulin-like growth factor-I (IGF-I) deficiency

    PubMed Central

    2012-01-01

    Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). IGF-I is a closely regulated hormone. Consequently, its logical therapeutical applications seems to be limited to restore physiological circulating levels in order to recover the clinical consequences of IGF-I deficiency, conditions where, despite continuous discrepancies, IGF-I treatment has never been related to oncogenesis. Currently the best characterized conditions of IGF-I deficiency are Laron Syndrome, in children; liver cirrhosis, in adults; aging including age-related-cardiovascular and neurological diseases; and more recently, intrauterine growth restriction. The aim of this review is to summarize the increasing list of roles of IGF-I, both in physiological and pathological conditions, underlying that its potential therapeutical options seem to be limited to those proven states of local or systemic IGF-I deficiency as a replacement treatment, rather than increasing its level upper the normal range. PMID:23148873

  4. Indirect searches for dark matter with the <i>Fermi> large area telescope

    SciTech Connect

    Albert, Andrea

    2015-03-24

    There is overwhelming evidence that non-baryonic dark matter constitutes ~ 27% of the energy density of the Universe. Weakly Interacting Massive Particles (WIMPs) are promising dark matter candidates that may produce γ rays via annihilation or decay detectable by the <i>Fermi> Large Area Telescope (LAT). A detection of WIMPs would also indicate the existence of physics beyond the Standard Model. We present recent results from the two cleanest indirect WIMP searches by the <i>Fermi>-LAT Collaboration: searches for γ-ray spectral lines and γ-ray emission associated with Milky Way dwarf spheroidal satellite galaxies.

  5. DNA ligase I, the replicative DNA ligase

    PubMed Central

    Howes, Timothy R.L.; Tomkinson, Alan E.

    2013-01-01

    Multiple DNA ligation events are required to join the Okazaki fragments generated during lagging strand DNA synthesis. In eukaryotes, this is primarily carried out by members of the DNA ligase I family. The C-terminal catalytic region of these enzymes is composed of three domains: a DNA binding domain, an adenylation domain and an OB-fold domain. In the absence of DNA, these domains adopt an extended structure but transition into a compact ring structure when they engage a DNA nick, with each of the domains contacting the DNA. The non-catalytic N-terminal region of eukaryotic DNA ligase I is responsible for the specific participation of these enzymes in DNA replication. This proline-rich unstructured region contains the nuclear localization signal and a PCNA interaction motif that is critical for localization to replication foci and efficient joining of Okazaki fragments. DNA ligase I initially engages the PCNA trimer via this interaction motif which is located at the extreme N-terminus of this flexible region. It is likely that this facilitates an additional interaction between the DNA binding domain and the PCNA ring. The similar size and shape of the rings formed by the PCNA trimer and the DNA ligase I catalytic region when it engages a DNA nick suggest that these proteins interact to form a double-ring structure during the joining of Okazaki fragments. DNA ligase I also interacts with replication factor C, the factor that loads the PCNA trimeric ring onto DNA. This interaction, which is regulated by phosphorylation of the non-catalytic N-terminus of DNA ligase I, also appears to be critical for DNA replication. PMID:22918593

  6. Ares I-X Flight Test Philosophy

    NASA Technical Reports Server (NTRS)

    Davis, S. R.; Tuma, M. L.; Heitzman, K.

    2007-01-01

    In response to the Vision for Space Exploration, the National Aeronautics and Space Administration (NASA) has defined a new space exploration architecture to return humans to the Moon and prepare for human exploration of Mars. One of the first new developments will be the Ares I Crew Launch Vehicle (CLV), which will carry the Orion Crew Exploration Vehicle (CEV), into Low Earth Orbit (LEO) to support International Space Station (ISS) missions and, later, support lunar missions. As part of Ares I development, NASA will perform a series of Ares I flight tests. The tests will provide data that will inform the engineering and design process and verify the flight hardware and software. The data gained from the flight tests will be used to certify the new Ares/Orion vehicle for human space flight. The primary objectives of this first flight test (Ares I-X) are the following: Demonstrate control of a dynamically similar integrated Ares CLV/Orion CEV using Ares CLV ascent control algorithms; Perform an in-flight separation/staging event between an Ares I-similar First Stage and a representative Upper Stage; Demonstrate assembly and recovery of a new Ares CLV-like First Stage element at Kennedy Space Center (KSC); Demonstrate First Stage separation sequencing, and quantify First Stage atmospheric entry dynamics and parachute performance; and Characterize the magnitude of the integrated vehicle roll torque throughout the First Stage (powered) flight. This paper will provide an overview of the Ares I-X flight test process and details of the individual flight tests.

  7. I-Xe ages of enstatite chondrites

    NASA Astrophysics Data System (ADS)

    Hopp, Jens; Trieloff, Mario; Ott, Ulrich

    2016-02-01

    In order to elucidate the early thermal history of enstatite chondrite parent bodies we determined 129I-129Xe whole rock ages of enstatite chondrites (5 EH, 2 EL, one EH impact melt) relative to the Shallowater reference meteorite (4562.3 ± 0.4 Ma, all errors are 1σ). I-Xe ages of both EL6 chondrites (LON 94100: -4.38 ± 0.60 Ma and Neuschwanstein: -3.87 ± 0.73 Ma - negative sign indicates ages younger than Shallowater) agree well with data of other EL6 chondrites. LON 94100 displayed a second isochron at lower temperatures equivalent to a younger age of -5.25 ± 1.17 Ma, perhaps reflecting different retention temperatures of respective carrier phases during sequential cooling. The enstatite chondrites Abee (EH4), Indarch (EH4), EET 96135 (EH4/5) and St. Marks (EH5) encompass a I-Xe age range of +0.57 ± 1.05 Ma (EET 96135 #1) to -0.45 ± 0.72 Ma (Abee), again in agreement with previously reported ages of EH chondrites. Only the age of St. Marks differs strongly from previously reported younger ages, now being more in accordance with other members of the EH clan. The EH3 chondrite Sahara 97096 showed the youngest I-Xe age of -7.87 ± 0.46 Ma distinctly younger than other I-Xe ages of EH chondrites, including other EH3s. Due to the apparent high retention temperature of the I-Xe system in enstatite (estimated >800 °C) this young age implies a later resetting of the I-Xe system by a severe thermal, likely impact-induced, event. The EH impact melt LAP 02225 records a similarly young thermal event. Though no isochron relationship could be established, the data fall within an apparent I-Xe age range of +5 to +15 Ma, similar to Sahara 97096. Overall, EH chondrite parent body experienced a thermal history determined by a complex interplay between impact disturbances and parent body metamorphism.

  8. The dwarf spheroidal galaxy Andromeda I

    SciTech Connect

    Mould, J.; Kristian, J. Mount Wilson and Las Campanas Observatories, Pasadena, CA )

    1990-05-01

    Images of Andromeda I in the visual and near-infrared show a giant branch characteristic of galactic globular clusters of intermediate metallicity. The distance of the galaxy is estimated from the tip of the giant branch to be 790 + or - 60 kpc. The physical dimensions and luminosity are similar to those of the dwarf spheroidal in Sculptor. There is no evidence for an intermediate age population in Andromeda I, and appropriate upper limits are specified. There is marginal evidence for a color gradient in the galaxy, a phenomenon not previously noted in a dwarf spheroidal. 21 refs.

  9. Autoindexing diffraction images with iMosflm

    SciTech Connect

    Powell, Harold R.; Johnson, Owen; Leslie, Andrew G. W.

    2013-07-01

    The principles of one-dimensional FFT-based autoindexing of diffraction images are described together with practical issues that may arise. A procedure for indexing multiple lattices as implemented in iMosflm is presented. An overview of autoindexing diffraction images based on one-@@dimensional fast Fourier transforms is presented. The implementation of the algorithm in the Mosflm/iMosflm program suite is described with a discussion of practical issues that may arise and ways of assessing the success or failure of the procedure. Recent developments allow indexing of images that show multiple lattices, and several examples demonstrate the success of this approach in real cases.

  10. Statistical fluctuations in the i132 model

    NASA Astrophysics Data System (ADS)

    Goodman, Alan L.

    1984-05-01

    The finite-temperature Hartree-Fock-Bogoliubov cranking equations are solved for the i132 model. For any temperature below kTc=0.2 MeV, rotations induce a sharp first-order phase transition. When statistical fluctuations in the pair gap Δ are included, the phase transition is smoothed out for 12Tci132 pair is unaffected by temperatures up to 0.5 MeV. The finite-temperature violation of the zero-temperature Hartree-Fock-Bogoliubov relation R2=R is given by the quasiparticle number fluctuation.

  11. iPSCs in Cardiovascular Drug Discovery

    PubMed Central

    Mercola, Mark; Colas, Alexandre; Willems, Erik

    2013-01-01

    The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells (iPSCs) has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating iPSC-based models of cardiovascular disease and their multiple applications in drug development. PMID:23371902

  12. How I Love My 80 Percenters

    NASA Technical Reports Server (NTRS)

    Maturo, Anthony J.

    2002-01-01

    Don't ever take your support staff for granted. By support staff, I mean the people in personnel, logistics, and finance; the ones who can make things happen with a phone call or a signature, or by the same token frustrate you to no end by their inaction; these are people you must depend on. I've spent a lot of time thinking about how to cultivate relationships with my support staff that work to the advantage of both of us. The most important thing that have learned working with people, any people--and I will tell you how I learned this in a minute--is there are some folks you just can't motivate, so forget it, don't try; others you certainly can with a little psychology and some effort; and the best of the bunch, what I call the 80 percenters, you don't need to motivate because they're already on the team and performing beautifully. The ones you can't change are rocks. Face up to it, and just kick them out of your way. I have a reputation with the people who don't want to perform or be part of the team. They don't come near me. If someone's a rock, I pick up on it right away, and I will walk around him or her to find someone better. The ones who can be motivated I take time to nurture. I consider them my projects. A lot of times these wannabes are people who want to help but don't know how. Listen, you can work with them. Lots of people in organizations have the mindset that all that matters are the regulations. God forbid if you ever work outside those regulations. They've got one foot on that regulation and they're holding it tight like a baby holds a blanket. What you're looking for is that first sign that their minds are opening. Usually you hear it in their vocabulary. What used to sound like "We can't do that ... the regulations won't allow it ... we have never done this before," well, suddenly that changes to "We have options ... let's take a look at the options ... let me research this and get back to you." The 80 percenters you want to nurture too, but

  13. Estimate of European 129I releases supported by 129I analysis in an Alpine ice core.

    PubMed

    Reithmeier, Herbert; Lazarev, Vitali; Rühm, Werner; Schwikowski, Ti Margit; Gäggeler, Heinz W; Nolte, Eckehart

    2006-10-01

    129I in the European environment originates predominantly from the industrial nuclear fuel reprocessing plants Sellafield (Great Britain), Marcoule, and La Hague (both France). While reliable data on 129I releases from La Hague exist for the whole period of operation, less is known about the contributions from Sellafield and Marcoule. For those periods where no data are available, i.e., for the first 16 years of the Sellafield operation and for the first 3 decades of the Marcoule operation, we estimated releases into the atmosphere of 118 GBq and 825 GBq, respectively. Hence, Marcoule was the major European source of airborne 129I, contributing about 45% to the total airborne 129I releases from all the European reprocessing facilities, until it was decommissioned in 1997. The estimated total emissions were compared with 129I deposition fluxes for the time period 1970-2002, obtained from the analysis of an ice core from Fiescherhorn glacier, Swiss Alps (46 degrees 33'N, 08 degrees 04'E; 3900 m asl). The temporal evolution of the 129I deposition agrees well with the total 129I releases into the atmosphere from the European reprocessing facilities and from atmospheric nuclear weapons tests, supporting our estimated release rates. However,the 129I concentrations and deposition fluxes at Fiescherhorn glacier were a factor of 6 lower than values obtained from the analysis of rainwater collected near Zurich (408 m asl) in Switzerland in the years 1994-97. This suggests a strong vertical concentration gradient of 129I, typical for water-soluble atmospheric trace species which are removed from the atmosphere in the course of days by precipitation scavenging, and must be taken into account if glaciers are used as an archive for a retrospective quantification of 129I deposition fluxes. In addition, the temporal evolution of the contribution of 129I re-emitted from the ocean's surface for the 129I inventory in the atmosphere was quantified for the first time. Although the

  14. The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection

    PubMed Central

    Ramanathan, Anand; Devarkar, Swapnil C.; Jiang, Fuguo; Miller, Matthew T.; Khan, Abdul G.; Marcotrigiano, Joseph; Patel, Smita S.

    2016-01-01

    RIG-I (Retinoic Acid Inducible Gene-I) is a cytosolic innate immune receptor that detects atypical features in viral RNAs as foreign to initiate a Type I interferon signaling response. RIG-I is present in an autoinhibited state in the cytoplasm and activated by blunt-ended double-stranded (ds)RNAs carrying a 5′ triphosphate (ppp) moiety. These features found in many pathogenic RNAs are absent in cellular RNAs due to post-transcriptional modifications of RNA ends. Although RIG-I is structurally well characterized, the mechanistic basis for RIG-I's remarkable ability to discriminate between cellular and pathogenic RNAs is not completely understood. We show that RIG-I's selectivity for blunt-ended 5′-ppp dsRNAs is ≈3000 times higher than non-blunt ended dsRNAs commonly found in cellular RNAs. Discrimination occurs at multiple stages and signaling RNAs have high affinity and ATPase turnover rate and thus a high katpase/Kd. We show that RIG-I uses its autoinhibitory CARD2-Hel2i (second CARD-helicase insertion domain) interface as a barrier to select against non-blunt ended dsRNAs. Accordingly, deletion of CARDs or point mutations in the CARD2-Hel2i interface decreases the selectivity from ≈3000 to 150 and 750, respectively. We propose that the CARD2-Hel2i interface is a ‘gate’ that prevents cellular RNAs from generating productive complexes that can signal. PMID:26612866

  15. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  16. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  17. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  18. 5 CFR 894.203 - If I have a self plus one enrollment, when may I change which family member I want to cover or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., when may I change which family member I want to cover or change to self only? 894.203 Section 894.203... plus one enrollment, when may I change which family member I want to cover or change to self only? You may change your covered family member under a self plus one enrollment or change to self only...

  19. 31 CFR 363.170 - What transactions can I conduct in a savings bond that I converted on which I am not registered...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... savings bond that I converted on which I am not registered as the owner, either coowner, or owner with... conduct in a savings bond that I converted on which I am not registered as the owner, either coowner, or owner with beneficiary? The only transaction that you may conduct on a savings bond that you...

  20. 5 CFR 839.621 - Can I cancel my FERS election if I was in the wrong retirement plan at the time I elected FERS...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Can I cancel my FERS election if I was in the wrong retirement plan at the time I elected FERS coverage and I have an election opportunity under the FERCCA? 839.621 Section 839.621 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS...

  1. Excitons in AgI-BASED-GLASSES and -

    NASA Astrophysics Data System (ADS)

    Fujishiro, Fumito; Mochizuki, Shosuke

    2007-01-01

    We summarize our recent optical studies on different pristine AgI films, different AgI-based glasses and different AgI-oxide fine particle composites. The exciton spectra of these specimens give useful information about the ionic and electronic structures at the AgI/glass and AgI/oxide particle interfaces.

  2. Comparative genomic analysis of nine <i>Sphingobium> strains: Insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways

    SciTech Connect

    Verma, Helianthous; Kumar, Roshan; Oldach, Phoebe; Sangwan, Naseer; Khurana, Jitendra P.; Gilbert, Jack A.; Lal, Rup

    2014-11-23

    Background: <i>Sphingobium> spp. are efficient degraders of a wide range of chlorinated and aromatic hydrocarbons. In particular, strains which harbour the <i>lin> pathway genes mediating the degradation of hexachlorocyclohexane (HCH) isomers are of interest due to the widespread persistence of this contaminant. Here, we examined the evolution and diversification of the <i>lin> pathway under the selective pressure of HCH, by comparing the draft genomes of six newly-sequenced <i>Sphingobium> spp. (strains LL03, DS20, IP26, HDIPO4, P25 and RL3) isolated from HCH dumpsites, with three existing genomes (<i>S. indicumi> B90A, <i>S. japonicumi> UT26S and <i>Sphingobium> sp. SYK6). Results: Efficient HCH degraders phylogenetically clustered in a closely related group comprising of UT26S, B90A, HDIPO4 and IP26, where HDIPO4 and IP26 were classified as subspecies with ANI value >98%. Less than 10% of the total gene content was shared among all nine strains, but among the eight HCH-associated strains, that is all except SYK6, the shared gene content jumped to nearly 25%. Genes associated with nitrogen stress response and two-component systems were found to be enriched. The strains also housed many xenobiotic degradation pathways other than HCH, despite the absence of these xenobiotics from isolation sources. In addition, these strains, although non-motile, but posses flagellar assembly genes. While strains HDIPO4 and IP26 contained the complete set of <i>lin> genes, DS20 was entirely devoid of <i>lin> genes (except <i>linKLMN>) whereas, LL03, P25 and RL3 were identified as <i>lin> deficient strains, as they housed incomplete <i>lin> pathways. Further, in HDIPO4, <i>linA> was found as a hybrid of two natural variants i.e., <i>linA1i> and <i>linA2i> known for their different enantioselectivity. In conclusion, the bacteria isolated from HCH dumpsites provide a natural testing ground to study variations in the <i>lin> system and their

  3. The Hawai'i Student Film Festival

    ERIC Educational Resources Information Center

    Olague, Robert

    2005-01-01

    This article discusses the Hawai'i Student Film Festival (HSFF) which is more than an annual festival. It also facilitates nine, year-round, student outreach programs that are available to more than 400 public and private schools statewide. Through these programs, HSFF offers a wide array of film and video opportunities and experiences for…

  4. ESEA Title I: Instructional Aides Program.

    ERIC Educational Resources Information Center

    Lile, Kurt; And Others

    The Title I Program in the Fremont Unified School District is located at two target schools. Currently there are 39 instructional aides employed. Aides were recruited through letters to parents and notices on shopping center bulletin boards in the target area. A committee including the principals of the two schools, the resource teachers, and a…

  5. FY06 I/O Integration Blueprint

    SciTech Connect

    Cupps, K; Fitzgerald, K; Gary, M; Shoopman, J; Hamilton, P; Loewe, B; Slavec, J; Smith, D; Fox, D; Southard, D; Wiltzuis, D; Allen, J; Bass, N; Boas, B; Connell, T; East, D; Gorda, B; Lawver, B; Louis, S; Quinn, T; Seager, M

    2006-04-06

    This document provides an understanding of the near and long term computing and I/O resources in the Secure Computing Facility (SCF) and Open Computing Facility (OCF). Requirements for data flows, storage capacities and transfer rates are determined. Recommendations are made for architectures, timeframes for major deliverables, and procurements for the next fiscal year.

  6. Maria Rubies I Garrofe (1932-1993)

    ERIC Educational Resources Information Center

    Baste, Carme Amoros

    2004-01-01

    This article profiles educator Maria Rubies I Garrofe. Rubies was a woman committed to education and the reconstruction of her country, Spain, equipped solely with the force of her convictions and her faith in dialogue. It is difficult to separate her personal commitment from her educational, social and political commitment. From the very outset…

  7. Heat of Sublimation of I-2.

    ERIC Educational Resources Information Center

    Henderson, Giles; Robarts, Ronald A., Jr.

    1978-01-01

    Describes an inexpensive double-beam laser photometry experiment to determine the molar heat of sublimation of I-2. The experiment employs common laboratory materials and components and gives results with a two percent to three percent accuracy. (Author/GA)

  8. May I Go to the Bathroom?

    ERIC Educational Resources Information Center

    Ferrell, Kathy

    2007-01-01

    "May I go to the bathroom?" While this hardly an unusual question from any middle-level student, the number of students who suddenly need to leave the room increases when a teacher assigns a textbook passage to read. Whether it is to use the restroom, visit their locker, or see the school nurse, these students will do just about anything to keep…

  9. Song Prompts: I Had a Cat

    ERIC Educational Resources Information Center

    Kenney, Susan Hobson

    2011-01-01

    This article discusses song prompts as a way to encourage children to sing during exploratory play. A song prompt for "I Had a Cat" is included for educators to try in their own classrooms or preschools. Educators are invited to share ideas they have used that encourage children to sing during free play.

  10. Teaching Science to ELLs, Part I

    ERIC Educational Resources Information Center

    Bautista, Nazan; Castaneda, Martha

    2011-01-01

    Since 1995, the population of English language learners (ELLs) in the United States has increased by an astonishing 57% (Maxwell 2009). Though ELLs come from many different backgrounds, they share the common challenge of learning English while responding to academic content demands. Part I of this two-part article provides key strategies every…

  11. Supplemental Instruction in Physical Chemistry I

    ERIC Educational Resources Information Center

    Toby, Ellen; Scott, Timothy P.; Migl, David; Kolodzeji, Elizabeth

    2016-01-01

    Physical chemistry I at Texas A&M University is an upper division course requiring mathematical and analytical skills. As such, this course poses a major problem for many Chemistry, Engineering, Biochemistry and Genetics majors. Comparisons between participants and non-participants in Supplemental Instruction for physical chemistry were made…

  12. Title I: Time to Get It Right

    ERIC Educational Resources Information Center

    Roza, Marguerite; Lake, Robin

    2015-01-01

    Congress enacted the Elementary and Secondary Education Act (ESEA) 50 years ago as part of President Lyndon B. Johnson's "War on Poverty." The most expansive federal education bill ever passed, it was developed as redress, establishing that poor children needed more educational services than wealthier children. Title I of the ESEA…

  13. PROTOPLANETARY DISK RESONANCES AND TYPE I MIGRATION

    SciTech Connect

    Tsang, David

    2011-11-10

    Waves reflected by the inner edge of a protoplanetary disk are shown to significantly modify Type I migration, even allowing the trapping of planets near the inner disk edge for small planets in a range of disk parameters. This may inform the distribution of planets close to their central stars, as observed recently by the Kepler mission.

  14. Interdisciplinary Studies Program. Teacher's Guide: Part I.

    ERIC Educational Resources Information Center

    Valencia Community Coll., Orlando, FL.

    This teacher's guide was developed for the first of four courses in Valencia Community College's Interdisciplinary Studies Program, a 2-year core general education curriculum which chronologically examines the major developments in the evolution of human knowledge. The guide provides an introductory overview of the semester's topic (i.e., the…

  15. MASFILE-I Pilot Project. Final Report.

    ERIC Educational Resources Information Center

    Five Associated Univ. Libraries, Syracuse, NY.

    The objectives of the MASFILE-I Pilot Project were (1) to test the utility and cost of compiling a manipulative data base from remote card files; (2) to test the utility of the Administrative Terminal System (ATS) for inputting bibliographic data into computer files from catalog card copy at a central location; (3) to test the adequacy of a…

  16. Operation hardtack I-1958. Technical report

    SciTech Connect

    Gladeck, F.R.; Gould, K.G.; Hallowell, J.H.; Martin, E.J.; McMullan, F.W.

    1982-12-01

    HARDTACK I was an atmospheric nuclear weapon test series held at Johnston Island and in the Marshall Islands at Enewetak and Bikini atolls in 1958. This is a report of DOD personnel in HARDTACK with an emphasis on operations and radiological safety.

  17. <i>NUSTAR> and <i>SUZAKU> X-ray spectroscopy of NGC 4151: Evidence for reflection from the inner accretion disk

    SciTech Connect

    Keck, M. L.; Brenneman, L. W.; Ballantyne, D. R.; Bauer, F.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Dauser, T.; Elvis, M.; Fabian, A. C.; Fuerst, F.; García, J.; Grefenstette, B. W.; Hailey, C. J.; Harrison, F. A.; Madejski, G.; Marinucci, A.; Matt, G.; Reynolds, C. S.; Stern, D.; Walton, D. J.; Zoghbi, A.

    2015-06-15

    We present X-ray timing and spectral analyses of simultaneous 150 ks <i>Nuclear Spectroscopic Telescope Array (NuSTAR)i> and <i>Suzaku> X-ray observations of the Seyfert 1.5 galaxy NGC 4151. We disentangle the continuum emission, absorption, and reflection properties of the active galactic nucleus (AGN) by applying inner accretion disk reflection and absorption-dominated models. With a time-averaged spectral analysis, we find strong evidence for relativistic reflection from the inner accretion disk. We find that relativistic emission arises from a highly ionized inner accretion disk with a steep emissivity profile, which suggests an intense, compact illuminating source. We find a preliminary, near-maximal black hole spin $a\\gt 0.9$ accounting for statistical and systematic modeling errors. We find a relatively moderate reflection fraction with respect to predictions for the lamp post geometry, in which the illuminating corona is modeled as a point source. Through a time-resolved spectral analysis, we find that modest coronal and inner disk reflection (IDR) flux variation drives the spectral variability during the observations. As a result, we discuss various physical scenarios for the IDR model and we find that a compact corona is consistent with the observed features.

  18. Computer Applications Project. Phase I. Final Report.

    ERIC Educational Resources Information Center

    Northwest Regional Educational Lab., Portland, OR.

    Phase I of this project for the development of educational materials to teach the use of the computer (1) as an aid to management and decision making, or (2) as an instructional tool, included expansion of background technical reports, completion of computer programs, printing of field test versions of materials, commercial publisher interaction,…

  19. 75 FR 51093 - Agency Information Collection Activities: Form I-864, Form I-864A, Form I-864EZ, and Form I-864W...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... on May 12, 2010, at 75 FR 26782, allowing for a 60-day public comment period. USCIS received 2... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-864.... Citizenship and Immigration Services (USCIS) will be submitting the following information collection...

  20. Expertise revisited, Part I-Interactional expertise.

    PubMed

    Collins, Harry; Evans, Robert

    2015-12-01

    In Part I of this two part paper we try to set out the 'essence' of the notion of interactional expertise by starting with its origins. In Part II we will look at the notion of contributory expertise. The exercise has been triggered by recent discussion of these concepts in this journal by Plaisance and Kennedy and by Goddiksen.

  1. Scientific Discoveries the Year I Was Born

    ERIC Educational Resources Information Center

    Cherif, Abour

    2012-01-01

    The author has successfully used a learning activity titled "The Year I Was Born" to motivate students to conduct historical research and present key scientific discoveries from their birth year. The activity promotes writing, helps students enhance their scientific literacy, and also improves their attitude toward the learning of science. As one…

  2. The Chapter I Challenge: Colorado's Contribution 1995.

    ERIC Educational Resources Information Center

    Petro, Janice Rose

    Chapter I of the Elementary and Secondary Education Act (ESEA) is the largest federally-funded program designed to provide services to elementary and secondary students to meet the special needs of educationally deprived students who reside in areas with high concentrations of low-income families. The 1994-95 school year is the last year of…

  3. How I Chose My Thesis Advisor

    NASA Astrophysics Data System (ADS)

    Karimabadi, Homa

    2011-01-01

    Professor K. Papadopoulos, or Dennis, who we have all come to him as, has had a profound influence over my career as a scientist as well as my private life. Here I provide a brief account of the events that led me to Dennis as my PhD thesis advisor at University of Maryland and what that has meant to me.

  4. Neurofibromatosis types I and II: radiological appearance.

    PubMed

    Romanowski, C A; Cavallin, L I

    1998-02-01

    The neurocutaneous disorders frequently involve the central nervous system. This, the first in a pair of articles which describe and illustrate the radiological appearances of the central nervous system manifestations of the most common neurocutaneous disorders, looks at neurofibromatosis types I and II.

  5. iNACOL's New Learning Models Vision

    ERIC Educational Resources Information Center

    International Association for K-12 Online Learning, 2013

    2013-01-01

    This brief summarizes iNACOL's New Learning Models, which personalize learning using competency-based approaches. Supported by blended and online learning modalities, teachers use technology to differentiate instruction and engage students in deeper learning. By adapting instruction to reflect a student's level of mastery, blended and online…

  6. Ares I-X Vibroacoustic Environments

    NASA Technical Reports Server (NTRS)

    Larsen, Curtis E.; Schuster, David M.; Kaufman, Daniel S.

    2009-01-01

    This paper provides a summary of the NASA Engineering and Safety Center (NESC) team recommendations and observations following participation with the Ares I-X Vibroacoustic (VA) Environments Panel in meetings at the Kennedy Space Center (KSC) and the Marshall Space Flight Center (MSFC) in March and April 2008, respectively.

  7. How I Learned to Conduct Focus Groups

    ERIC Educational Resources Information Center

    Del Rio-Roberts, Maribel

    2011-01-01

    The use of focus groups may provide researchers with important insights into research questions via participant discussion and interaction. As a human services practitioner and researcher, I became interested in learning how to conduct focus groups in order to apply these steps to my research and gain valuable insights about the human experience…

  8. Interactive Multiple Object Tracking (iMOT)

    PubMed Central

    Thornton, Ian M.; Bülthoff, Heinrich H.; Horowitz, Todd S.; Rynning, Aksel; Lee, Seong-Whan

    2014-01-01

    We introduce a new task for exploring the relationship between action and attention. In this interactive multiple object tracking (iMOT) task, implemented as an iPad app, participants were presented with a display of multiple, visually identical disks which moved independently. The task was to prevent any collisions during a fixed duration. Participants could perturb object trajectories via the touchscreen. In Experiment 1, we used a staircase procedure to measure the ability to control moving objects. Object speed was set to 1°/s. On average participants could control 8.4 items without collision. Individual control strategies were quite variable, but did not predict overall performance. In Experiment 2, we compared iMOT with standard MOT performance using identical displays. Object speed was set to 2°/s. Participants could reliably control more objects (M = 6.6) than they could track (M = 4.0), but performance in the two tasks was positively correlated. In Experiment 3, we used a dual-task design. Compared to single-task baseline, iMOT performance decreased and MOT performance increased when the two tasks had to be completed together. Overall, these findings suggest: 1) There is a clear limit to the number of items that can be simultaneously controlled, for a given speed and display density; 2) participants can control more items than they can track; 3) task-relevant action appears not to disrupt MOT performance in the current experimental context. PMID:24498288

  9. Sexual Harassment, Parts I, II, and III.

    ERIC Educational Resources Information Center

    Douglas, Joel M., Ed.

    1992-01-01

    Three separate newsletter issues examine the issue of sexual harassment on college campuses. Part I contains a general introduction to the topic and two articles. The first of these discusses the definition of sexual harassment by the United States Equal Employment Opportunity Commission (EEOC) and the courts, the EEOC guidelines on conduct of a…

  10. 75 FR 26782 - Agency Information Collection Activities: Form I-864, Form I-864A, Form I-864EZ, and Form I-864W...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-864... Exemption; OMB Control No. 1615-0075. The Department of Homeland Security, U.S. Citizenship and Immigration...-864W; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will be asked...

  11. Successful Strategies for I-9 Compliance.

    ERIC Educational Resources Information Center

    Lange, Cynthia J.; Cowen, Nancy S.

    1992-01-01

    A discussion of federal regulations concerning completion of Immigration and Naturalization Service Form I-9 (to verify a potential employee's legal status) looks at the current state of the law and offers college and university personnel administrators practical suggestions for implementing it consistently. Reevaluation of institutional policies,…

  12. Keys to Cooperative Education Programs. Volume I.

    ERIC Educational Resources Information Center

    National Child Labor Committee, New York, NY.

    This first volume of a two-volume manual provides a structure for the analysis of the design of cooperative education and the implementation of the design in terms of the 49 key elements of cooperative education. It is intended for use by persons responsible for cooperative education at state and local levels. Volume I contains the introduction…

  13. Liposome technology. Volume I: Preparation of liposomes

    SciTech Connect

    Gregoriadis, G.

    1984-01-01

    These three volumes cover liposome technology in pharmacology and medicine. Contributors emphasize methodology used in their own laboratories, and include a brief introduction, coverage of relevant literature, applications and critical evaluations for the methods they describe. Volume I examine methods for the preparation of liposomes and auxiliary techniques.

  14. FY07 I/O Integration Blueprint

    SciTech Connect

    Wiltzius, D P; Gary, M R

    2006-12-28

    This document provides an understanding of the near and long term computing and I/O resources in the Secure Computing Facility (SCF) and Open Computing Facility (OCF). Requirements for data flows, storage capacities and transfer rates are determined. Recommendations are made for architectures, timeframes for major deliverables, and procurements for the next fiscal year.

  15. A case of achondrogenesis type I.

    PubMed

    Bökesoy, I; Aydin, E; Gazilerli, S

    1984-01-01

    A case of achondrogenesis type I was observed in a stillborn infant of consanguineous parents. Additional abnormalities included cleft palate, corneal clouding, ear deformities, aplastic testes, and anal atresia. Radiological and histological findings are evaluated for the differential diagnosis. PMID:6469245

  16. SSIP Phase I Writing Guide: Indicator 11

    ERIC Educational Resources Information Center

    Lucas, Anne; Kelley, Grace

    2014-01-01

    The purpose of this document is to support States in writing the narrative for Phase I of the State Systemic Improvement Plan (SSIP). It provides an outline for States to use in organizing their narrative content to ensure that all required components are addressed. The outline includes considerations on information States might include in their…

  17. User Fees I: The Economic Argument.

    ERIC Educational Resources Information Center

    Gell, Marilyn Killebrew

    1979-01-01

    Reviews current methods of public library financing through governmental support at the local, state, and federal level. The imposition of user fees is proposed as a method of preserving equity; i.e., individuals receiving the benefits would bear the costs. (JVP)

  18. Teaching Elementary Particle Physics: Part I

    ERIC Educational Resources Information Center

    Hobson, Art

    2011-01-01

    I'll outline suggestions for teaching elementary particle physics, often called "high energy physics," in high school or introductory college courses for non-scientists or scientists. Some presentations of this topic simply list the various particles along with their properties, with little overarching structure. Such a laundry list approach is a…

  19. Solvation of electronically excited I2 -

    NASA Astrophysics Data System (ADS)

    Maslen, P. E.; Papanikolas, J. M.; Faeder, J.; Parson, R.; ONeil, S. V.

    1994-10-01

    The interaction potentials between the six lowest electronic states of I-2 and an arbitrary discrete charge distribution are calculated approximately using a one-electron model. The model potentials are much easier to calculate than ab initio potentials, with the cost of a single energy point scaling linearly with the number of solvent molecules, enabling relatively large systems to be studied. Application of the model to simulation of electronically excited I-2 in liquids and CO2 clusters is discussed. In a preliminary application, solvent effects are approximated by a uniform electric field. If electronically excited (2Πg,1/2) I-2 undergoes dissociation in the presence of a strong electric field, the negative charge localizes so as to minimize the total potential energy. However, in a weak field the negative charge localizes in the opposite direction, maximizing the potential energy. Based on a study of the field-dependent potential surfaces, a solvent-transfer mechanism is proposed for the electronic relaxation of 2Πg,1/2I-2, in contrast to the conventional view of relaxation via electron transfer.

  20. Gold(I)-catalyzed enantioselective cycloaddition reactions.

    PubMed

    López, Fernando; Mascareñas, José L

    2013-10-30

    In recent years there have been extraordinary developments of gold(I)-catalyzed enantioselective processes. This includes progress in the area of cycloaddition reactions, which are of particular interest due to their potential for the rapid construction of optically active cyclic products. In this article we will summarize some of the most remarkable examples, emphasizing reaction mechanisms and key intermediates involved in the processes.

  1. iCosmo: an interactive cosmology package

    NASA Astrophysics Data System (ADS)

    Refregier, A.; Amara, A.; Kitching, T. D.; Rassat, A.

    2011-04-01

    Aims: The interactive software package iCosmo, designed to perform cosmological calculations is described. Methods: iCosmo is a software package to perfom interactive cosmological calculations for the low-redshift universe. Computing distance measures, the matter power spectrum, and the growth factor is supported for any values of the cosmological parameters. It also computes derived observed quantities for several cosmological probes such as cosmic shear, baryon acoustic oscillations, and type Ia supernovae. The associated errors for these observable quantities can be derived for customised surveys, or for pre-set values corresponding to current or planned instruments. The code also allows for calculation of cosmological forecasts with Fisher matrices, which can be manipulated to combine different surveys and cosmological probes. The code is written in the IDL language and thus benefits from the convenient interactive features and scientific libraries available in this language. iCosmo can also be used as an engine to perform cosmological calculations in batch mode, and forms a convenient adaptive platform for the development of further cosmological modules. With its extensive documentation, it may also serve as a useful resource for teaching and for newcomers to the field of cosmology. Results: The iCosmo package is described with a number of examples and command sequences. The code is freely available with documentation at http://www.icosmo.org, along with an interactive web interface and is part of the Initiative for Cosmology, a common archive for cosmological resources.

  2. Spacecraft and their Boosters. Aerospace Education I.

    ERIC Educational Resources Information Center

    Coard, E. A.

    This book, one in the series on Aerospace Education I, provides a description of some of the discoveries that spacecraft have made possible and of the experience that American astronauts have had in piloting spacecraft. The basic principles behind the operation of spacecraft and their boosters are explained. Descriptions are also included on…

  3. iSTEM: Learning Mathematics through Minecraft

    ERIC Educational Resources Information Center

    Bos, Beth; Wilder, Lucy; Cook, Marcelina; O'Donnell, Ryan

    2014-01-01

    The Common Core State Standards can be taught with Minecraft, an interactive creative Lego®-like game. Integrating Science, Technology, Engineering, and Mathematics (iSTEM) authors share ideas and activities that stimulate student interest in the integrated fields of science, technology, engineering, and mathematics (STEM) in K-grade 6 classrooms.

  4. Why Should I Be a Teacher?

    ERIC Educational Resources Information Center

    Block, Alan A.

    2008-01-01

    Though teaching yet has its advocates, more and more teachers are leaving the profession after only a few years in the school setting. The satisfactions of this impossibly complex and difficult profession are less and less obvious in this era of accountability and high stakes testing. Indeed, I suggest that the satisfactions often ascribed to the…

  5. Interstellar carbon I lines in zeta Ophiuchi

    NASA Technical Reports Server (NTRS)

    De Boer, K. S.; Morton, D. C.

    1974-01-01

    With two f-values of C I lines obtained from the spectra of zeta Pup and gamma(2) Vel, it is shown that the interstellar C I spectrum in zeta Oph obeys an optical-depth relation similar to that for Na I, and the relative strengths of 19 multiplets are determined from this relation. The dominant processes which excite neutral carbon are used to calculate populations of the fine-structure levels as functions of the density of H nuclei and the temperature, and evidence is found that the C I lines are formed in the dense cloud in front of zeta Oph at a heliocentric velocity of -14.4 km/s. It is noted that the observed column-density ratios of the neutral carbon fine-structure levels lead to a total H nuclei density of about 220 to 660 per cu cm, while the electron density and observed C(+) abundance indicate a value of 10,000 per cu cm, with a 0.05 pc thick gas layer.

  6. Pregnancy: Should I Use a Seat Belt?

    MedlinePlus

    ... injury or death in the event of a car crash. You should wear a seat belt no matter where you sit in the car. How should I wear my seat belt? The ... together keep you from being thrown from the car during an accident. The shoulder strap also keeps ...

  7. What I Talk about When I Talk about Teaching and Learning

    ERIC Educational Resources Information Center

    Safstrom, Carl Anders

    2011-01-01

    In this text I discuss two events in which I learned something important about life and about education in order to formulate in a precise manner two propositions for my pedagogical creed. In focus for both are the interrelatedness of theory and life. The stories are told through the lenses of Emmanuel Levinas's and Jacques Ranciere's thinking,…

  8. 40 CFR 1048.135 - How must I label and identify the engines I produce?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Emission Standards and Related Requirements § 1048.135 How must I label and identify the engines I produce... engine. (6) Identify the emission control system. Use terms and abbreviations as described in 40 CFR...

  9. 40 CFR 1048.135 - How must I label and identify the engines I produce?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Emission Standards and Related Requirements § 1048.135 How must I label and identify the engines I produce... engine. (6) Identify the emission control system. Use terms and abbreviations as described in 40 CFR...

  10. 40 CFR 1048.135 - How must I label and identify the engines I produce?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Emission Standards and Related Requirements § 1048.135 How must I label and identify the engines I produce... engine. (6) Identify the emission control system. Use terms and abbreviations as described in 40 CFR...

  11. 40 CFR 1048.135 - How must I label and identify the engines I produce?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Emission Standards and Related Requirements § 1048.135 How must I label and identify the engines I produce... engine. (6) Identify the emission control system. Use terms and abbreviations as described in 40 CFR...

  12. 40 CFR 1048.135 - How must I label and identify the engines I produce?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Emission Standards and Related Requirements § 1048.135 How must I label and identify the engines I produce...) The label must— (1) Include the heading “EMISSION CONTROL INFORMATION”. (2) Include your...

  13. 30 CFR 285.910 - What must I do when I remove my facility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do when I remove my facility? 285.910 Section 285.910 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF...

  14. σ54-dependent regulome in <i>Desulfovibrio vulgarisi> Hildenborough

    SciTech Connect

    Kazakov, Alexey E.; Rajeev, Lara; Chen, Amy; Luning, Eric G.; Dubchak, Inna; Mukhopadhyay, Aindrila; Novichkov, Pavel S.

    2015-11-10

    The σ54 subunit controls a unique class of promoters in bacteria. Such promoters, without exception, require enhancer binding proteins (EBPs) for transcription initiation. <i>Desulfovibrio vulgarisi> Hildenborough, a model bacterium for sulfate reduction studies, has a high number of EBPs, more than most sequenced bacteria. Finally, the cellular processes regulated by many of these EBPs remain unknown.

  15. 30 CFR 550.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false If I conduct ancillary activities, what notices must I provide? 550.208 Section 550.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT... least 30 calendar days before you conduct any G&G exploration or development G&G activity (see §...

  16. 30 CFR 550.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false If I conduct ancillary activities, what notices must I provide? 550.208 Section 550.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT... least 30 calendar days before you conduct any G&G exploration or development G&G activity (see §...

  17. 30 CFR 550.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false If I conduct ancillary activities, what notices must I provide? 550.208 Section 550.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT... least 30 calendar days before you conduct any G&G exploration or development G&G activity (see §...

  18. 20 CFR 411.135 - What do I do when I receive a ticket?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Section 411.135 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Tickets Under the Ticket to Work Program § 411.135 What do I do when I receive a ticket? Your participation in the Ticket to Work program is voluntary. When you receive your ticket, you are free to...

  19. 20 CFR 411.135 - What do I do when I receive a ticket?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Section 411.135 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Tickets Under the Ticket to Work Program § 411.135 What do I do when I receive a ticket? Your participation in the Ticket to Work program is voluntary. When you receive your ticket, you are free to...

  20. 20 CFR 411.135 - What do I do when I receive a ticket?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Section 411.135 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Tickets Under the Ticket to Work Program § 411.135 What do I do when I receive a ticket? Your participation in the Ticket to Work program is voluntary. When you receive your ticket, you are free to...