46 CFR 30.10-45 - Ocean-TB/O.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Ocean-TB/O. 30.10-45 Section 30.10-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-45 Ocean—TB/O. Under this designation shall be included all tank vessels normally navigating the waters of any ocean or...

45 CFR 30.8 - Required administrative proceedings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Required administrative proceedings. 30.8 Section 30.8 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION.... See for example, 42 CFR part 50 (Public Health Service), 45 CFR part 16 (Departmental Grant Appeals...

45 CFR 30.10 - Collection activities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Collection activities. 30.10 Section 30.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Standards for the Administrative Collection of Debts § 30.10 Collection activities. (a) General rule. The Secretary shall...

45 CFR 30.20 - Taxpayer information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Taxpayer information. 30.20 Section 30.20 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Standards for the Administrative Collection of Debts § 30.20 Taxpayer information. (a) When attempting to locate a debtor in order...

A novel approach to synthesize, studies of structural and electrical characteristic of Bi(Ni0.30Ti0.30Fe0.40)O3 nanoceramics

NASA Astrophysics Data System (ADS)

Kumar, Nitin; Shukla, Alok

2018-03-01

In this study, we report a novel approach to synthesize the Bi(Ni0.30Ti0.30Fe0.40)O3 [arbitration BNTF30/40] nanoceramics by standard ceramic method at an ambient temperature of 1013 K. Carbonates and oxides powder were utilised as a raw materials in an appropriate stoichiometric amounts. X-ray diffraction pattern assigned that the BNTF30/40 sample presents a single phase of orthorhombic symmetry. The crystallite size obtain from X-ray data suggests the formation of BNTF30/40 nanoceramics in the range between 20 to 45 nm. Bulk density of the prepared pallets were measured and found to be more than 94 percent. The basic characterization tools have been used respectively with Field Emission Scanning Electron Microscope and Spectroscopy based techniques to obtain the correlation between surface morphology and electrical characteristic of specimen sample. Electrical characteristic of the as- synthesized material was studied in the experimental temperature range between RT to 623 K at different operated frequency (25 kHz - 500 kHz).

Utilization of geothermal energy-feasibility study, Ojo Caliente Mineral Springs Company, Ojo Caliente, New Mexico

NASA Astrophysics Data System (ADS)

1982-04-01

The feasibility of a geothermal heating system at the Ojo Caliente Mineral Springs Co. was investigated. The geothermal energy will be used to preheat hot water for the laundry facilities and to heat the water for a two pipe fan coil heating system in the hotel. Present annual heating fuel costs of $11,218 for propane will be replaced by electricity to operate fans and pump at an annual cost of $2547, resulting in a net savings of $8671. Installation costs include $10,100 for a well system, $1400 for a laundry system, and $41,100 for a heating system. With the addition of a 10% design fee the total installation cost is $57,860. Ignoring escalating propane fuel prices, tax credits for energy conservation equipment, and potential funding from the State of New Mexico for a geothermal demonstration project, the simple economic payback period for this project is 6.7 years.

45 CFR 1301.30 - General requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false General requirements. 1301.30 Section 1301.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START...

45 CFR 1301.30 - General requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false General requirements. 1301.30 Section 1301.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START...

45 CFR 1301.30 - General requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false General requirements. 1301.30 Section 1301.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START...

45 CFR 1301.30 - General requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false General requirements. 1301.30 Section 1301.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START...

45 CFR 1301.30 - General requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false General requirements. 1301.30 Section 1301.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START...

45 CFR 30.11 - Demand for payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Demand for payment. 30.11 Section 30.11 Public... Administrative Collection of Debts § 30.11 Demand for payment. (a) Written demand for payment. (1) Written demand...) Normally, the demand letter will be sent no later than 30 days after the appropriate official determines...

45 CFR 30.35 - Preservation of evidence.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Preservation of evidence. 30.35 Section 30.35 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Referrals to the Department of Justice § 30.35 Preservation of evidence. The Secretary will maintain and...

45 CFR 30.7 - Subdivision of claims.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Subdivision of claims. 30.7 Section 30.7 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION General Provisions § 30.7 Subdivision of claims. Debts may not be subdivided to avoid the monetary ceiling...

30 CFR 45.4 - Independent contractor register.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Independent contractor register. 45.4 Section... ADMINISTRATIVE REQUIREMENTS INDEPENDENT CONTRACTORS § 45.4 Independent contractor register. (a) Each independent contractor shall provide the production-operator in writing the following information: (1) The independent...

30 CFR 45.1 - Scope and purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... implementation of MSHA's enforcement policy of holding independent contractors responsible for violations... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Scope and purpose. 45.1 Section 45.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR FILING AND OTHER ADMINISTRATIVE...

30 CFR 45.1 - Scope and purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... implementation of MSHA's enforcement policy of holding independent contractors responsible for violations... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Scope and purpose. 45.1 Section 45.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR FILING AND OTHER ADMINISTRATIVE...

45 CFR 30.22 - Bases for compromise.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Bases for compromise. 30.22 Section 30.22 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.22 Bases for compromise. (a) Compromise. The Secretary may compromise a debt if the full amount...

45 CFR 30.22 - Bases for compromise.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Bases for compromise. 30.22 Section 30.22 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.22 Bases for compromise. (a) Compromise. The Secretary may compromise a debt if the full amount...

45 CFR 30.22 - Bases for compromise.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Bases for compromise. 30.22 Section 30.22 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.22 Bases for compromise. (a) Compromise. The Secretary may compromise a debt if the full amount...

45 CFR 30.22 - Bases for compromise.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Bases for compromise. 30.22 Section 30.22 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.22 Bases for compromise. (a) Compromise. The Secretary may compromise a debt if the full amount...

45 CFR 30.21 - Scope and application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope and application. 30.21 Section 30.21 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.21 Scope and application. (a) Scope. The standards set forth in this subpart apply to the...

45 CFR 30.5 - Other administrative remedies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Other administrative remedies. 30.5 Section 30.5... Provisions § 30.5 Other administrative remedies. The remedies and sanctions available under this part for... administrative remedy which may be available for collecting debts owed to the Department, such as converting the...

45 CFR 30.5 - Other administrative remedies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Other administrative remedies. 30.5 Section 30.5... Provisions § 30.5 Other administrative remedies. The remedies and sanctions available under this part for... administrative remedy which may be available for collecting debts owed to the Department, such as converting the...

45 CFR 1386.30 - State plan requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false State plan requirements. 1386.30 Section 1386.30... § 1386.30 State plan requirements. (a) In order to receive Federal financial assistance under this... in effect, a State Plan which meets the requirements of sections 122 and 124 of the Act (42 U.S.C...

45 CFR 1386.30 - State plan requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false State plan requirements. 1386.30 Section 1386.30... § 1386.30 State plan requirements. (a) In order to receive Federal financial assistance under this... in effect, a State Plan which meets the requirements of sections 122 and 124 of the Act (42 U.S.C...

45 CFR 1386.30 - State plan requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false State plan requirements. 1386.30 Section 1386.30... § 1386.30 State plan requirements. (a) In order to receive Federal financial assistance under this... in effect, a State Plan which meets the requirements of sections 122 and 124 of the Act (42 U.S.C...

45 CFR 1355.30 - Other applicable regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Other applicable regulations. 1355.30 Section 1355.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES...

45 CFR 1355.30 - Other applicable regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Other applicable regulations. 1355.30 Section 1355.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES...

45 CFR 1355.30 - Other applicable regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Other applicable regulations. 1355.30 Section 1355.30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES...

45 CFR 605.24-605.30 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false [Reserved] 605.24-605.30 Section 605.24-605.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

45 CFR 205.30 - Methods of administration.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true Methods of administration. 205.30 Section 205.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

45 CFR 205.30 - Methods of administration.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false Methods of administration. 205.30 Section 205.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

45 CFR 205.30 - Methods of administration.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false Methods of administration. 205.30 Section 205.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

45 CFR 205.30 - Methods of administration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Methods of administration. 205.30 Section 205.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

45 CFR 205.30 - Methods of administration.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Methods of administration. 205.30 Section 205.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC...

45 CFR 1151.25-1151.30 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false [Reserved] 1151.25-1151.30 Section 1151.25-1151.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NONDISCRIMINATION ON THE BASIS OF HANDICAP Discrimination...

45 CFR 1151.25-1151.30 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false [Reserved] 1151.25-1151.30 Section 1151.25-1151.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NONDISCRIMINATION ON THE BASIS OF HANDICAP Discrimination...

45 CFR 1151.25-1151.30 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false [Reserved] 1151.25-1151.30 Section 1151.25-1151.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NONDISCRIMINATION ON THE BASIS OF HANDICAP Discrimination...

45 CFR 1151.25-1151.30 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false [Reserved] 1151.25-1151.30 Section 1151.25-1151.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NONDISCRIMINATION ON THE BASIS OF HANDICAP Discrimination...

45 CFR 1151.25-1151.30 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false [Reserved] 1151.25-1151.30 Section 1151.25-1151.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NONDISCRIMINATION ON THE BASIS OF HANDICAP Discrimination...

45 CFR 1170.25-1170.30 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false [Reserved] 1170.25-1170.30 Section 1170.25-1170.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NONDISCRIMINATION ON THE BASIS OF HANDICAP IN FEDERALLY...

45 CFR 1170.25-1170.30 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false [Reserved] 1170.25-1170.30 Section 1170.25-1170.30 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NONDISCRIMINATION ON THE BASIS OF HANDICAP IN FEDERALLY...

45 CFR 303.30 - Securing medical support information.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true Securing medical support information. 303.30 Section 303.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT... HUMAN SERVICES STANDARDS FOR PROGRAM OPERATIONS § 303.30 Securing medical support information. (a) If...

45 CFR 96.30 - Fiscal and administrative requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Fiscal and administrative requirements. 96.30 Section 96.30 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Financial Management § 96.30 Fiscal and administrative requirements. (a) Fiscal control and accounting...

45 CFR 96.30 - Fiscal and administrative requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Fiscal and administrative requirements. 96.30 Section 96.30 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION BLOCK GRANTS Financial Management § 96.30 Fiscal and administrative requirements. (a) Fiscal control and accounting...

45 CFR 96.30 - Fiscal and administrative requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Fiscal and administrative requirements. 96.30 Section 96.30 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Financial Management § 96.30 Fiscal and administrative requirements. (a) Fiscal control and accounting...

45 CFR 96.30 - Fiscal and administrative requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Fiscal and administrative requirements. 96.30 Section 96.30 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Financial Management § 96.30 Fiscal and administrative requirements. (a) Fiscal control and accounting...

45 CFR 402.30 - Basis of awards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Basis of awards. 402.30 Section 402.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN... award constitutes the authority to draw and expend funds for the purposes set forth in the Act and this...

30 CFR 817.45 - Hydrologic balance: Sediment control measures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Hydrologic balance: Sediment control measures. 817.45 Section 817.45 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT...-UNDERGROUND MINING ACTIVITIES § 817.45 Hydrologic balance: Sediment control measures. (a) Appropriate sediment...

30 CFR 816.45 - Hydrologic balance: Sediment control measures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Hydrologic balance: Sediment control measures. 816.45 Section 816.45 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT...-SURFACE MINING ACTIVITIES § 816.45 Hydrologic balance: Sediment control measures. (a) Appropriate sediment...

30 CFR 816.45 - Hydrologic balance: Sediment control measures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Hydrologic balance: Sediment control measures. 816.45 Section 816.45 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT...-SURFACE MINING ACTIVITIES § 816.45 Hydrologic balance: Sediment control measures. (a) Appropriate sediment...

30 CFR 817.45 - Hydrologic balance: Sediment control measures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Hydrologic balance: Sediment control measures. 817.45 Section 817.45 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT...-UNDERGROUND MINING ACTIVITIES § 817.45 Hydrologic balance: Sediment control measures. (a) Appropriate sediment...

30 CFR 45.3 - Identification of independent contractors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Identification of independent contractors. 45.3... ADMINISTRATIVE REQUIREMENTS INDEPENDENT CONTRACTORS § 45.3 Identification of independent contractors. (a) Any independent contractor may obtain a permanent MSHA identification number. To obtain an identification number...

E-Learning 3.0 = E-Learning 2.0 + Web 3.0?

ERIC Educational Resources Information Center

Hussain, Fehmida

2012-01-01

Web 3.0, termed as the semantic web or the web of data is the transformed version of Web 2.0 with technologies and functionalities such as intelligent collaborative filtering, cloud computing, big data, linked data, openness, interoperability and smart mobility. If Web 2.0 is about social networking and mass collaboration between the creator and…

45 CFR 30.9 - No private rights created.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false No private rights created. 30.9 Section 30.9 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION General Provisions § 30.9 No private rights created. The standards in this part do not create any right or benefit...

45 CFR 30.24 - Joint and several liability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Joint and several liability. 30.24 Section 30.24 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.24 Joint and several liability. (a) When two or more debtors are jointly and severally liable...

45 CFR 30.34 - Claims Collection Litigation Report.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Claims Collection Litigation Report. 30.34 Section 30.34 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Referrals to the Department of Justice § 30.34 Claims Collection Litigation Report. (a)(1) Unless excepted by Justice, the Secretary will complete...

ENVIRONMENTAL ASSESSMENT FOR THE PROPOSED WITHDRAWAL OF PUBLIC LANDS WITHIN AND SURROUNDING THE CALIENTE RAIL CORRIDOR, NEVADA

DOE Office of Scientific and Technical Information (OSTI.GOV)

DOE

2005-12-01

The purpose for agency action is to preclude surface entry and the location of new mining claims, subject to valid existing rights, within and surrounding the Caliente rail corridor as described in the Yucca Mountain FEIS (DOE 2002). This protective measure is needed to enhance the safe, efficient, and uninterrupted evaluation of land areas for potential rail alignments within the Caliente rail corridor. The evaluation will assist the DOE in determining, through the Rail Alignment environmental impact statement (EIS) process, whether to construct a branch rail line, and to provide support to the BLM in deciding whether or not tomore » reserve a ROW for the rail line under the Federal Land Policy and Management Act (FLPMA). The BLM participated as a cooperating agency in preparing this EA because it is the responsible land manager and BLM staff could contribute resource specific expertise.« less

45 CFR 303.30 - Securing medical support information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Securing medical support information. 303.30 Section 303.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND...

45 CFR 303.30 - Securing medical support information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Securing medical support information. 303.30... (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES STANDARDS FOR PROGRAM OPERATIONS § 303.30 Securing medical support information. (a) If...

45 CFR 303.30 - Securing medical support information.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false Securing medical support information. 303.30... (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES STANDARDS FOR PROGRAM OPERATIONS § 303.30 Securing medical support information. (a) If...

30 CFR 36.45 - Quantity of ventilating air.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Quantity of ventilating air. 36.45 Section 36... TRANSPORTATION EQUIPMENT Test Requirements § 36.45 Quantity of ventilating air. (a) Results of the engine tests shall be used to calculate ventilation (cubic feet of air per minute) that shall be supplied by positive...

30 CFR 36.45 - Quantity of ventilating air.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Quantity of ventilating air. 36.45 Section 36... TRANSPORTATION EQUIPMENT Test Requirements § 36.45 Quantity of ventilating air. (a) Results of the engine tests shall be used to calculate ventilation (cubic feet of air per minute) that shall be supplied by positive...

30 CFR 36.45 - Quantity of ventilating air.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Quantity of ventilating air. 36.45 Section 36... TRANSPORTATION EQUIPMENT Test Requirements § 36.45 Quantity of ventilating air. (a) Results of the engine tests shall be used to calculate ventilation (cubic feet of air per minute) that shall be supplied by positive...

45 CFR 305.0 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... implements Federal audit requirements under sections 409(a)(8) and 452(a)(4) of the Act. Sections 305.0... 45 Public Welfare 2 2011-10-01 2011-10-01 false Scope. 305.0 Section 305.0 Public Welfare...), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES PROGRAM PERFORMANCE MEASURES...

45 CFR 303.30 - Securing medical support information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false Securing medical support information. 303.30 Section 303.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT... noncustodial parent; (4) Name and social security number of child(ren); (5) Home address of noncustodial parent...

45 CFR 1801.30 - Continuation into graduate study.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Continuation into graduate study. 1801.30 Section... FOUNDATION HARRY S. TRUMAN SCHOLARSHIP PROGRAM Graduate Study § 1801.30 Continuation into graduate study. (a... shall be eligible for continued Foundation support for an approved program of graduate study. (b) The...

45 CFR 1801.30 - Continuation into graduate study.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Continuation into graduate study. 1801.30 Section... FOUNDATION HARRY S. TRUMAN SCHOLARSHIP PROGRAM Graduate Study § 1801.30 Continuation into graduate study. (a... shall be eligible for continued Foundation support for an approved program of graduate study. (b) The...

45 CFR 304.30 - Public sources of State's share.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false Public sources of State's share. 304.30 Section 304.30 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT... HUMAN SERVICES FEDERAL FINANCIAL PARTICIPATION § 304.30 Public sources of State's share. (a) Public...

45 CFR 30.1 - Purpose, authority, and scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Purpose, authority, and scope. 30.1 Section 30.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION General... authorized under the Federal Claims Collection Act, as amended, Public Law No. 89-508, 80 Stat. 308 (July 19...

45 CFR 30.25 - Further review of compromise offers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Further review of compromise offers. 30.25 Section 30.25 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.25 Further review of compromise offers. If the Secretary is uncertain whether to...

46 CFR 167.45-30 - Use of approved fire-fighting equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PUBLIC NAUTICAL SCHOOL SHIPS Special Firefighting and Fire Prevention Requirements § 167.45-30 Use of approved fire-fighting equipment. Portable fire extinguishers or fire-extinguishing systems which conform... 46 Shipping 7 2010-10-01 2010-10-01 false Use of approved fire-fighting equipment. 167.45-30...

Ocular pharmacokinetics of 0.45% ketorolac tromethamine

PubMed Central

Attar, Mayssa; Schiffman, Rhett; Borbridge, Lisa; Farnes, Quinn; Welty, Devin

2010-01-01

Purpose A new carboxymethylcellulose (CMC)-containing ophthalmic formulation of 0.45% ketorolac, pH 6.8 (Acuvail®) was recently developed for treatment of inflammation and pain after cataract surgery. This study compared pharmacokinetics of the new formulation with that of a prior formulation, 0.4% ketorolac, pH 7.4 (Acular LS®). Methods Ketorolac formulations were administered bilaterally (35 μL) to female New Zealand White rabbits. Samples from aqueous humor and iris-ciliary body were collected at multiple time points, and ketorolac was quantified using liquid chromatography-tandem mass spectrometry. Results In aqueous humor, the peak concentration (Cmax) and area under the concentration-time curve (AUC0–τ) of ketorolac were, respectively, 389 ng/mL and 939 ng·h/mL following administration of the CMC-containing 0.45% ketorolac, pH 6.8, and 211 ng/mL and 465 ng·hr/mL following administration of the 0.4% ketorolac, pH 7.4. In iris-ciliary body, Cmax and AUC0–τ of ketorolac were, respectively 450 ng/g and 2040 ng·h/g after administration of the CMC-containing 0.45% ketorolac, pH 6.8, and 216 ng/g and 699 ng·h/g after administration of the 0.4% ketorolac, pH 7.4. PK simulations predicted an AUC0–τ of 2910 ng·h/g for twice daily, CMC-containing 0.45% ketorolac, pH 6.8, compared to 725 ng·h/g for 4 times daily, 0.4% ketorolac, pH 7.4. Conclusions The CMC-containing formulation of 0.45% ketorolac, pH 6.8, increased ketorolac bioavailability by 2-fold in aqueous humor and by 3-fold in iris-ciliary body in comparison to the 0.4% ketorolac, pH 7.4, allowing a reduced dosing schedule from 4 times daily to twice daily. PMID:21179226

Ocular pharmacokinetics of 0.45% ketorolac tromethamine.

PubMed

Attar, Mayssa; Schiffman, Rhett; Borbridge, Lisa; Farnes, Quinn; Welty, Devin

2010-12-01

A new carboxymethylcellulose (CMC)-containing ophthalmic formulation of 0.45% ketorolac, pH 6.8 (Acuvail(®)) was recently developed for treatment of inflammation and pain after cataract surgery. This study compared pharmacokinetics of the new formulation with that of a prior formulation, 0.4% ketorolac, pH 7.4 (Acular LS(®)). Ketorolac formulations were administered bilaterally (35 μL) to female New Zealand White rabbits. Samples from aqueous humor and iris-ciliary body were collected at multiple time points, and ketorolac was quantified using liquid chromatography-tandem mass spectrometry. In aqueous humor, the peak concentration (C(max)) and area under the concentration-time curve (AUC(0-τ)) of ketorolac were, respectively, 389 ng/mL and 939 ng·h/mL following administration of the CMC-containing 0.45% ketorolac, pH 6.8, and 211 ng/mL and 465 ng·hr/mL following administration of the 0.4% ketorolac, pH 7.4. In iris-ciliary body, C(max) and AUC(0-τ) of ketorolac were, respectively 450 ng/g and 2040 ng·h/g after administration of the CMC-containing 0.45% ketorolac, pH 6.8, and 216 ng/g and 699 ng·h/g after administration of the 0.4% ketorolac, pH 7.4. PK simulations predicted an AUC(0-τ) of 2910 ng·h/g for twice daily, CMC-containing 0.45% ketorolac, pH 6.8, compared to 725 ng·h/g for 4 times daily, 0.4% ketorolac, pH 7.4. The CMC-containing formulation of 0.45% ketorolac, pH 6.8, increased ketorolac bioavailability by 2-fold in aqueous humor and by 3-fold in iris-ciliary body in comparison to the 0.4% ketorolac, pH 7.4, allowing a reduced dosing schedule from 4 times daily to twice daily.

Mineralogy, structural control and age of the Incachule Sb epithermal veins, the Cerro Aguas Calientes collapse caldera, Central Puna

NASA Astrophysics Data System (ADS)

Salado Paz, Natalia; Petrinovic, Iván; Do Campo, Margarita; Brod, José Affonso; Nieto, Fernando; da Silva Souza, Valmir; Wemmer, Klauss; Payrola, Patricio; Ventura, Roberto

2018-03-01

The Incachule Sb epithermal veins is located near to the N-E rim of the Cerro Aguas Calientes collapse caldera (17.5-10.8 Ma), in the geologic province of Puna, Salta- Argentina. It is hosted in Miocene felsic volcanic rocks with continental arc signature. The district includes twelve vein systems with mineralization of Sb occurring in hydrothermal breccias and stockwork. The veins are composed of quartz-sulfide with pyrite, stibnite and arsenopyrite. All around the veins, wall rocks are variably altered to clay minerals and sulfates in an area of around 2.5 km wide by more than 7 km long. The hydrothermal alterations recognized are: silicic, phyllic and argillic. The veins are characterized by high contents of Sb, As, and Tl and intermediate contents of Pb-Zn-Cu, and traces of Ag and Au. Homogenization and ice-melting temperatures of fluid inclusions vary from 125 °C to 189 °C and -2.4 °C to -0.8 °C. The isotopic data indicated a range of δ34S -3.04‰ to +0.72‰ consistent with a magmatic source for sulfur. We present the firsts K-Ar ages for hydrothermal illite/smectite mixed layers (I/SR1, 60% illite layers) and illite that constrain the age of the ore deposit (8.5-6.7 ± 0.2 Ma). The data shown here, let characterized the Incachule district as a shallow low sulfidation epithermal system hosted in a collapse caldera. Our data also indicate that mineralization is structurally controlled by a fault system related to the 10.3 Ma collapse of Aguas Calientes caldera. The interpreted local stress field is consistent with the regional one.

Gamma rays of 0.3 to 30 MeV from PSR 0531+21

NASA Technical Reports Server (NTRS)

White, R. S.; Sweeney, W.; Tuemer, T.; Zych, A. D.

1985-01-01

Pulsed gamma rays from the Crab Pulsar PSR 0531+21 are reported for energies of 0.3 to 30 MeV. The observations were carried out with the UCR gamma ray double Compton scatter telescope launched on a balloon from Palestine, Texas at 4.5 GV, at 2200 LT, September 29, 1978. Two 8 hr observations of the pulsar were made, the first starting at 0700 UT (0200 LT) September 30 just after reaching float altitude of 4.5 g/sq cm. Analysis of the total gamma ray flux from the Crab Nebula plus pulsar using telescope vertical cell pairs was published previously. The results presented supersede the preliminary ones. The double scatter mode of the UCR telescope measures the energy of each incident gamma ray from 1 to 30 MeV and its incident angle to a ring on the sky. The time of arrival is measured to 0.05 ms. The direction of the source is obtained from overlapping rings on the sky. The count rate of the first scatter above a threshold of 0.3 MeV is recorded every 5.12 ms. The Crab Pulsar parameters were determined from six topocentric arrival times of optical pulses.

15 CFR 0.735-45 - Notice.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Disciplinary Actions Concerning Post-Employment Conflict of Interest Violations § 0.735-45 Notice. (a) The Director shall notify the former employee of the proposed disciplinary action in writing by registered or...

45 CFR 606.30 - General prohibitions against discrimination.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false General prohibitions against discrimination. 606... THE NATIONAL SCIENCE FOUNDATION § 606.30 General prohibitions against discrimination. (a) No qualified... benefits of, or otherwise be subjected to discrimination under any program or activity conducted by the...

45 CFR 30.19 - Review of cost effectiveness of collection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Review of cost effectiveness of collection. 30.19... COLLECTION Standards for the Administrative Collection of Debts § 30.19 Review of cost effectiveness of... the cost effectiveness of alternative collection techniques, establish guidelines with respect to...

The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery.

PubMed

Jung, Ji Won; Chung, Byung Hoon; Kim, Eung Kweon; Seo, Kyoung Yul; Kim, Tae-im

2015-11-01

To compare the additive effects of two types of non-steroidal anti-inflammatory drugs (NSAIDs), bromfenac 0.1% or ketorolac 0.45%, relative to topical steroid alone in cataract surgery. A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0.1%; Group 2, pre/postoperative preservative-free ketorolac 0.45%; and Group 3, postoperative steroid only, as a control. Outcome measures included intraoperative change in pupil size, postoperative anterior chamber inflammation control, change in macular thickness and volume, and ocular surface status after operation. Both NSAID groups had smaller intraoperative pupil diameter changes compared to the control group (p<0.05). There was significantly less ocular inflammation 1 week and 1 month postoperatively in both NSAID groups than the control group. The changes in central foveal subfield thickness measured before the operation and at postoperative 1 month were 4.30±4.25, 4.87±6.03, and 12.47±12.24 μm in groups 1 to 3, respectively. In the control group, macular thickness and volume increased more in patients with diabetes mellitus (DM), compared to those without DM. In contrast, in both NSAID groups, NSAIDs significantly reduced macular changes in subgroups of patients with or without DM. Although three ocular surface parameters were worse in group 1 than in group 2, these differences were not significant. Adding preoperative and postoperative bromfenac 0.1% or ketorolac 0.45% to topical steroid can reduce intraoperative miosis, postoperative inflammation, and macular changes more effectively than postoperative steroid alone.

Basic psychometric properties of the transfer assessment instrument (version 3.0).

PubMed

Tsai, Chung-Ying; Rice, Laura A; Hoelmer, Claire; Boninger, Michael L; Koontz, Alicia M

2013-12-01

To refine the Transfer Assessment Instrument (TAI 2.0), develop a training program for the TAI, and analyze the basic psychometric properties of the TAI 3.0, including reliability, standard error of measurement (SEM), minimal detectable change (MDC), and construct validity. Repeated measures. A winter sports clinic for disabled veterans. Wheelchair users (N=41) who perform sitting-pivot or standing-pivot transfers. Not applicable. TAI version 3.0, intraclass correlation coefficients, SEMs, and MDCs for reliable measurement of raters' responses. Spearman correlation coefficient, 1-way analysis of variance, and independent t tests to evaluate construct validity. TAI 3.0 had acceptable to high levels of reliability (range, .74-.88). The SEMs for part 1, part 2, and final scores ranged from .45 to .75. The MDC was 1.5 points on the 10-point scale for the final score. There were weak correlations (ρ range, -.13 to .25; P>.11) between TAI final scores and subjects' characteristics (eg, sex, body mass index, age, type of disability, length of wheelchair use, grip and elbow strength, sitting balance). With comprehensive training, the refined TAI 3.0 yields high reliability among raters of different clinical backgrounds and experience. TAI 3.0 was unbiased toward certain physical characteristics that may influence transfer. TAI fills a void in the field by providing a quantitative measurement of transfers and a tool that can be used to detect problems and guide transfer training. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

40 CFR 30.45 - Cost and price analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Cost and price analysis. 30.45 Section... price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be accomplished in various ways...

Health informatics 3.0.

PubMed

Kalra, Dipak

2011-01-01

Web 3.0 promises us smart computer services that will interact with each other and leverage knowledge about us and our immediate context to deliver prioritised and relevant information to support decisions and actions. Healthcare must take advantage of such new knowledge-integrating services, in particular to support better co-operation between professionals of different disciplines working in different locations, and to enable well-informed co-operation between clinicians and patients. To grasp the potential of Web 3.0 we will need well-harmonised semantic resources that can richly connect virtual teams and link their strategies to real-time and tailored evidence. Facts, decision logic, care pathway steps, alerts, education need to be embedded within components that can interact with multiple EHR systems and services consistently. Using Health Informatics 3.0 a patient's current situation could be compared with the outcomes of very similar patients (from across millions) to deliver personalised care recommendations. The integration of EHRs with biomedical sciences ('omics) research results and predictive models such as the Virtual Physiological Human could help speed up the translation of new knowledge into clinical practice. The mission, and challenge, for Health Informatics 3.0 is to enable healthy citizens, patients and professionals to collaborate within a knowledge-empowered social network in which patient specific information and personalised real-time evidence are seamlessly interwoven.

High Angle of Attack Missile Aerodynamics at Mach Numbers 0.30 to 1.5

DTIC Science & Technology

1980-11-01

I AFWAL-TR-80-3070 I 45~//1° 4. N3B2 Cn 3d . 35 10 -2 36 30 37 50 2- S Cy ’ -1I __- 40 0 45 CAh ------ 50 -555 70- * 6C 50 504 40 ZS 8 9 LO R*N a 4. 5...Continued) 36. Drescher, H., "Messung Der Auf Querange-Sti"mte Zylinder Ausgeubten Zeitlich Verabderten Druck ," Z.F. Flugwss, Vol. 4, No. 1/2, 1956

45 CFR 79.30 - The hearing and burden of proof.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false The hearing and burden of proof. 79.30 Section 79.30 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL... by a preponderance of the evidence. (d) The hearing shall be open to the public unless otherwise...

ASPEN Version 3.0

NASA Technical Reports Server (NTRS)

Rabideau, Gregg; Chien, Steve; Knight, Russell; Schaffer, Steven; Tran, Daniel; Cichy, Benjamin; Sherwood, Robert

2006-01-01

The Automated Scheduling and Planning Environment (ASPEN) computer program has been updated to version 3.0. ASPEN is a modular, reconfigurable, application software framework for solving batch problems that involve reasoning about time, activities, states, and resources. Applications of ASPEN can include planning spacecraft missions, scheduling of personnel, and managing supply chains, inventories, and production lines. ASPEN 3.0 can be customized for a wide range of applications and for a variety of computing environments that include various central processing units and random access memories.

Integrated Lunar Information Architecture for Decision Support Version 3.0 (ILIADS 3.0)

NASA Technical Reports Server (NTRS)

Talabac, Stephen; Ames, Troy; Blank, Karin; Hostetter, Carl; Brandt, Matthew

2013-01-01

ILIADS 3.0 provides the data management capabilities to access CxP-vetted lunar data sets from the LMMP-provided Data Portal and the LMMP-provided On-Moon lunar data product server. (LMMP stands for Lunar Mapping and Modeling Project.) It also provides specific quantitative analysis functions to meet the stated LMMP Level 3 functional and performance requirements specifications that were approved by the CxP. The purpose of ILIADS 3.0 is to provide an integrated, rich client lunar GIS software application

The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery

PubMed Central

Jung, Ji Won; Chung, Byung Hoon; Kim, Eung Kweon; Seo, Kyoung Yul

2015-01-01

Purpose To compare the additive effects of two types of non-steroidal anti-inflammatory drugs (NSAIDs), bromfenac 0.1% or ketorolac 0.45%, relative to topical steroid alone in cataract surgery. Materials and Methods A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0.1%; Group 2, pre/postoperative preservative-free ketorolac 0.45%; and Group 3, postoperative steroid only, as a control. Outcome measures included intraoperative change in pupil size, postoperative anterior chamber inflammation control, change in macular thickness and volume, and ocular surface status after operation. Results Both NSAID groups had smaller intraoperative pupil diameter changes compared to the control group (p<0.05). There was significantly less ocular inflammation 1 week and 1 month postoperatively in both NSAID groups than the control group. The changes in central foveal subfield thickness measured before the operation and at postoperative 1 month were 4.30±4.25, 4.87±6.03, and 12.47±12.24 µm in groups 1 to 3, respectively. In the control group, macular thickness and volume increased more in patients with diabetes mellitus (DM), compared to those without DM. In contrast, in both NSAID groups, NSAIDs significantly reduced macular changes in subgroups of patients with or without DM. Although three ocular surface parameters were worse in group 1 than in group 2, these differences were not significant. Conclusion Adding preoperative and postoperative bromfenac 0.1% or ketorolac 0.45% to topical steroid can reduce intraoperative miosis, postoperative inflammation, and macular changes more effectively than postoperative steroid alone. PMID:26446653

Enterprise 3.0 in Engineering Education

ERIC Educational Resources Information Center

Ahrens, Andreas; Zascerinska, Jelena

2011-01-01

Enterprise 3.0 offers potential solutions for the quality, maintenance and sustainable development of services. The synergy between Enterprise 3.0 and engineering education advances the development of innovative products, processes and services in the European economy. Aim of the research is to analyze student engineers' use of Enterprise 3.0…

28 CFR 0.30 - General functions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false General functions. 0.30 Section 0.30... Service § 0.30 General functions. The following-described matters are assigned to, and shall be conducted... performance of the functions vested in the Attorney General by sections 204(d), 205, 1002, and 1003(a) of the...

Geochronologic and paleomagnetic evidence defining the relationship between the Miocene Hiko and Racer Canyon tuffs, eccentric outflow lobes from the Caliente caldera complex, southeastern Great Basin, USA

USGS Publications Warehouse

Gromme, S.; Deino, A.M.; Best, M.G.; Hudson, M.R.

1997-01-01

Outflow sheets of the Hiko tuff and the Racer Canyon tuff, which together extend over approximately 16000 km2 around the Caliente caldera complex in southeastern Nevada, have long been considered to be products of simultaneous or near-simultaneous eruptions from inset calderas in the west and east ends, respectively, of the caldera complex. New high-precision 40Ar/39Ar geochronology and paleomagnetic data demonstrate that emplacement of the uppermost part of the Racer Canyon tuff at 18.33??0.03 Ma was nearly synchronous with emplacement of the single outflow cooling unit of the much larger overlying Hiko tuff at 18.32??0.04 Ma. Based on comparison with the geomagnetic polarity time scale derived from the sea-floor spreading record, we conclude that emplacement of the first of several outflow cooling units of the Racer Canyon tuff commenced approximately 0.5 m.y. earlier. Only one paleomagnetic polarity is found in the Hiko tuff, but at least two paleomagnetic reversals have been found in the Racer Canyon tuff. The two formations overlap in only one place, at and near Panaca Summit northeast of the center of the Caliente caldera complex; here the Hiko tuff is stratigraphically above the Racer Canyon tuff. This study demonstrates the power of combining 40Ar/39Ar and paleomagnetic data in conjunction with phenocryst compositional modes to resolve problematic stratigraphic correlations in complex ash-flow sequences where use of one method alone might not eliminate ambiguities.

45 CFR 201.0 - Scope and applicability.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false Scope and applicability. 201.0 Section 201.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS TO STATES FOR PUBLIC...

45 CFR 201.0 - Scope and applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Scope and applicability. 201.0 Section 201.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS TO STATES FOR PUBLIC...

45 CFR 201.0 - Scope and applicability.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true Scope and applicability. 201.0 Section 201.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS TO STATES FOR PUBLIC...

45 CFR 201.0 - Scope and applicability.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Scope and applicability. 201.0 Section 201.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS TO STATES FOR PUBLIC...

45 CFR 201.0 - Scope and applicability.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false Scope and applicability. 201.0 Section 201.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS TO STATES FOR PUBLIC...

43 CFR 45.30 - What will the Hearings Division do with a case referral?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What will the Hearings Division do with a case referral? 45.30 Section 45.30 Public Lands: Interior Office of the Secretary of the Interior CONDITIONS AND PRESCRIPTIONS IN FERC HYDROPOWER LICENSES Hearing Process General Provisions Related to...

45 CFR 30.27 - Mutual release of the debtor and the Government.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Mutual release of the debtor and the Government. 30.27 Section 30.27 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION Debt Compromise § 30.27 Mutual release of the debtor and the Government. In all...

Gadolinium Enhanced MR Coronary Vessel Wall Imaging at 3.0 Tesla.

PubMed

Kelle, Sebastian; Schlendorf, Kelly; Hirsch, Glenn A; Gerstenblith, Gary; Fleck, Eckart; Weiss, Robert G; Stuber, Matthias

2010-10-11

Purpose. We evaluated the influence of the time between low-dose gadolinium (Gd) contrast administration and coronary vessel wall enhancement (LGE) detected by 3T magnetic resonance imaging (MRI) in healthy subjects and patients with coronary artery disease (CAD). Materials and Methods. Four healthy subjects (4 men, mean age 29 ± 3 years and eleven CAD patients (6 women, mean age 61 ± 10 years) were studied on a commercial 3.0 Tesla (T) whole-body MR imaging system (Achieva 3.0 T; Philips, Best, The Netherlands). T1-weighted inversion-recovery coronary magnetic resonance imaging (MRI) was repeated up to 75 minutes after administration of low-dose Gadolinium (Gd) (0.1 mmol/kg Gd-DTPA). Results. LGE was seen in none of the healthy subjects, however in all of the CAD patients. In CAD patients, fifty-six of 62 (90.3%) segments showed LGE of the coronary artery vessel wall at time-interval 1 after contrast. At time-interval 2, 34 of 42 (81.0%) and at time-interval 3, 29 of 39 evaluable segments (74.4%) were enhanced. Conclusion. In this work, we demonstrate LGE of the coronary artery vessel wall using 3.0 T MRI after a single, low-dose Gd contrast injection in CAD patients but not in healthy subjects. In the majority of the evaluated coronary segments in CAD patients, LGE of the coronary vessel wall was already detectable 30-45 minutes after administration of the contrast agent.

Passage of Campylobacter subtypes through 0.45 and 0.65 µm filters.

USDA-ARS?s Scientific Manuscript database

Introduction A 0.45 or 0.65 µm filter can be used as a means to separate Campylobacter from complex samples allowing detection on solid plating media. It is unclear what percentage of cells in a Campylobacter suspension pass through a filter and result in visible colonies. Purpose The objective o...

3.0 T plaque imaging.

PubMed

Hinton-Yates, Denise P; Cury, Ricardo C; Wald, Lawrence L; Wiggins, Graham C; Keil, Boris; Seethmaraju, Ravi; Gangadharamurthy, Dakshinamurthy; Ogilvy, Christopher S; Dai, Guangping; Houser, Stuart L; Stone, James R; Furie, Karen L

2007-10-01

The aim of this article is to evaluate 3.0 T magnetic resonance imaging for characterization of vessel morphology and plaque composition. Emphasis is placed on early and moderate stages of carotid atherosclerosis, where increases in signal-to-noise (SNR) and contrast-to-noise (CNR) ratios compared with 1.5 T are sought. Comparison of in vivo 3.0 T imaging to histopathology is performed for validation. Parallel acceleration methods applied with an 8-channel carotid array are investigated as well as higher field ex vivo imaging to explore even further gains. The overall endeavor is to improve prospective assessment of atherosclerosis stage and stability for reduction of atherothrombotic event risk. A total of 10 male and female subjects ranging in age from 22 to 72 years (5 healthy and 5 with cardiovascular disease) participated. Custom-built array coils were used with endogenous and exogenous multicontrast bright and black-blood protocols for 3.0 T carotid imaging. Comparisons were performed to 1.5 T, and ex vivo plaque was stained with hematoxylin and eosin for histology. Imaging (9.4 T) was also performed on intact specimens. The factor of 2 gain in signal-to-noise SNR is realized compared with 1.5 T along with improved wall-lumen and plaque component CNR. Post-contrast black-blood imaging within 5-10 minutes of gadolinium injection is optimal for detection of the necrotic lipid component. In a preliminary 18-month follow-up study, this method provided measurement of a 50% reduction in lipid content with minimal change in plaque size in a subject receiving aggressive statin therapy. Parallel imaging applied with signal averaging further improves 3.0 T black-blood vessel wall imaging. The use of 3.0 T for carotid plaque imaging has demonstrated increases in SNR and CNR compared with 1.5 T. Quantitative prospective studies of moderate and early plaques are feasible at 3.0 T. Continued improvements in coil arrays, 3-dimensional pulse sequences, and the use of novel

45 CFR 1306.30 - Provisions of comprehensive child development services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Provisions of comprehensive child development... Start Program Options § 1306.30 Provisions of comprehensive child development services. (a) All Head Start grantees must provide comprehensive child development services, as defined in the Head Start...

45 CFR 1306.30 - Provisions of comprehensive child development services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Provisions of comprehensive child development... Start Program Options § 1306.30 Provisions of comprehensive child development services. (a) All Head Start grantees must provide comprehensive child development services, as defined in the Head Start...

45 CFR 1306.30 - Provisions of comprehensive child development services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Provisions of comprehensive child development... Start Program Options § 1306.30 Provisions of comprehensive child development services. (a) All Head Start grantees must provide comprehensive child development services, as defined in the Head Start...

45 CFR 1306.30 - Provisions of comprehensive child development services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Provisions of comprehensive child development... Start Program Options § 1306.30 Provisions of comprehensive child development services. (a) All Head Start grantees must provide comprehensive child development services, as defined in the Head Start...

[Evaluation of the compliance of semirecumbent position between 30-45° in intubated patients].

PubMed

Vinagre Gaspar, R; Morales Sánchez, C; Frade Mera, M J; Zaragoza García, I; Guirao Moya, A; Cuenca Solanas, M; García Fuentes, C; Alted López, E

2011-01-01

To determine compliance of the standard "semirecumbent position between 30-45° in patients with artificial airway (AA)". To know the opinion of the professionals on this issue. An observational, prospective study was carried out in December 2009 in the ICU department of a tertiary hospital that excluded the limitation of therapeutic effort, prone position and antitrendelemburg. headrest angle, professional experience of the nurse, shift, perception of the auditor, diagnostic, type of AA (tracheostomy or endotracheal tube), mechanical ventilation (MV) (yes/no) and enteral nutrition (EN). Nurses were surveyed to verify if they knew the standard, if they complied with it, the method used and their suggestions. We used the Student's t test and ANOVA for multivariable analysis, and Fisher's χ2; p<0.05=significant. A total of 546 valid measurements were obtained from 53 patients, of which 40.9% had the correct semirecumbent position (30-45°). Professionals with <1 year of experience were those who raised the headrest the least, with only 26.4% of these measurements over 30°. The standard was met in only 34.8% of the neurocritical patients (NC) vs non NC (46.7%) (p<0.05). It was <30° in 29.2% of patients with tracheostomy vs 44% measurements performed on patients with TOT (p<0.05). There were no differences between shifts, the use of MV or EN. Diagnostic accuracy of the auditor: sensitivity: 91.6%; specificity: 72.5%; positive predictive value: 70.2%; negative predictive value (NPV): 92.4%. 97.9% of responders know the standard. Visual judgment was used in 97.2% of the cases. Measured compliance was less than 50% although the standard is well known by the nursing team. Even though the subjective perception has a high NPV, it does not achieve the standard. Copyright © 2010 Elsevier España, S.L. y SEEIUC. All rights reserved.

45 CFR 30.4 - Compromise, waiver, or disposition under other statutes not precluded.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Compromise, waiver, or disposition under other statutes not precluded. 30.4 Section 30.4 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CLAIMS COLLECTION General Provisions § 30.4 Compromise, waiver, or disposition under other...

New 30-50 Ghz Wideband Receiver for Nobeyama 45-M Telescope with Capability to Observe Three Zeeman

NASA Astrophysics Data System (ADS)

Huang, Yau De

2018-01-01

Zeeman measurement is the only tool to probe the magnetic field strengths directly. A new receiver covering 30-50 GHz frequency range is proposed for Nobeyama 45-m telescope based on the design of the ALMA Band 1 receiver. With dual linear polarization feed, wide IF bandwidth and state-of-the-art noise performance, it is capable to observe three Zeeman transitions (SO at 30.0 GHz and CCS at 33.7 and 45.4 GHz) toward the pre-protostellar cores simultaneously. This feature will not only increase the survey efficiency but also provide a reliable tool to calibrate the unwanted instrumental cross-polarization. Slim receiver layout also allows easy expansion to form focal plane array. We will present the receiver design and the current status of the pro

Sedimentology of the Simmler and Vaqueros formations in the Caliente Range-Carrizo Plain area, California

USGS Publications Warehouse

Bartow, J. Alan

1974-01-01

The Simmler and Vaqueros Formations in the Caliente Range-Carrizo Plain area make up a large part of the thick Tertiary sedimentary sequence that was .deposited in a basin which lay along the southwest side of the present-day San Andreas fault. The evolution of this basin during Oligocene and early Miocene time and the relationship of its sedimentary record to the tectonic history is an important chapter in the Tertiary history of California. The Simmler Formation, of provincial Oligocene to early Miocene age, unconformably overlies basement rocks and an Upper Cretaceous-lower Tertiary marine sequence. It consists of a sandstone facies, which is mostly a variegated sequence of sandstone and mudstone occurring in fining-upward cycles, and a conglomerate facies, which occurs around the southwest and southeast margins of the basin. The conformably overlying Vaqueros Formation, of provincial early to middle Miocene age, is subdivided from base upward ,into the Quail Canyon Sandstone, Soda Lake Shale, and Painted Rock Sandstone Members. The Vaqueros intertongues eastward, southeastward, and northward with the continental Caliente Formation and is conformably overlain by the Monterey Shale. In the Caliente Range, northeast of major thrust faults, the Vaqueros may reach a thickness of 8,700 feet (2,650 m). Around the margin of the basin, the formation is much thinner--locally only 200 feet (60 m) thick--and is generally undivided. The Quail Canyon Sandstone Member is composed of cross-bedded or planar-stratified sandstone. The Soda Lake Shale Member consists mostly of siltstone and platy shale with a few thin sandstone interbeds. The Painted Rock Sandstone Member, the thickest and coarsest member, consists mostly of large lenticular bodies of thick-bedded coarse-grained sandstone and thinner units of siltstone. Petrology and paleocurrent studies indicate that, in a given subarea, the Simmler and Vaqueros Formations were derived from the same source terrane and that the

45 CFR 605.0 - Adoption of HHS regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and Human... 45 Public Welfare 3 2011-10-01 2011-10-01 false Adoption of HHS regulations. 605.0 Section 605.0... phrase appears in § 605.4(b)(5) and in Subpart C (§§ 605.21 through 605.23). The date for compliance with...

45 CFR 2530.30 - What steps are necessary to transfer an education award?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false What steps are necessary to transfer an education award? 2530.30 Section 2530.30 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE TRANSFER OF EDUCATION AWARDS § 2530.30 What steps are necessary...

Progradational sequences in Miocene shoreline deposits, southeastern Caliente Range, California

USGS Publications Warehouse

Clifton, H. Edward

1981-01-01

An exceptionally well exposed marine-nonmarine transition in middle Miocene strata exists in the southeastern Caliente Range, California. About 50 individual progradational sequences form a succession that ranges in thickness from approximately 1000 m (where predominantly nonmarine) to more than 2500 m (where predominantly marine). Paleogreographic evidence in basalt flows near the top of the succession and in overlying fluvial deposists indicates that these middle Miocene strata were deposited across a north-northwest trending shoreline.A complete progradational sequence typically is several meters to a few tens of meters thick and includes strata that represent three intertonguing stratigraphic units. Individual sequences generally rest on a thin gravel deposit interpreted as a transgressive lag on an erosional surface. The gravel is overlain by structureless siltstone or fine-grained sandstone deposited at water depths where the rate of faunal mixing exceeded that of production of structures by physical processes. These rocks grade upward into bedded fine sandstone deposited closer to shore where physical processes exceeded bioturbation. Crossbedded lenses of coarse sand or fine gravel in the upper part of this facies suggest the presence of failry long-period surface waves. The bedded fine sandstone is sharply overlain by a crossbedded coarse sandstone facies that is interpreted as a combined offshore bar-rip channel-surf zone assemblage. Cross-strata dip dominantly offshore, suggesting substantial deposition from rip currents. A secondary, shore=parallel mode of cross-strata direction suggests longshore currents produced by surface waves from the northwest. The crossbedded coarse-grained sandstone grades upward into planar-bedded medium-grained sandstone that is interpreted as a beach foreshore. This facies grades upward through structureless medium-grained sandstone into nonmarine or lagoonal red and green mudstone of the Caliente Formation.The middle Miocene

Narrow- (3.0 mm) Versus Standard-Diameter (4.0 and 4.5 mm) Implants for Splinted Partial Fixed Restoration of Posterior Mandibular and Maxillary Jaws: A 5-Year Retrospective Cohort Study.

PubMed

Pieri, Francesco; Forlivesi, Caterina; Caselli, Ernesto; Corinaldesi, Giuseppe

2017-04-01

Evidence concerning predictability of narrow-diameter implants (NDIs) (<3.3 mm) to restore partially edentulous posterior maxillary and mandibular areas is limited. The aim of this study is to compare the 5-year outcomes of NDIs (3.0 mm) and standard-diameter implants (SDIs) (4.0 to 4.5 mm) supporting fixed partial dentures (FPDs) in posterior mandibular and maxillary jaws. All patients treated with at least two adjacent NDIs or SDIs according to available bone thickness and with a minimum follow-up of 5 years after placement were invited to undergo a clinical and radiologic examination. Outcome measures were implant and FPD failures, biologic and prosthetic complications, and marginal bone loss. A total of 107 out of 127 patients attended the examination: 49 (113 implants) of the NDI group, and 58 (126 implants) of the SDI group. Two NDIs failed in one patient versus four SDIs in four patients (P = 0.37). One FPD failed in the NDI group versus two FPDs in the SDI group (P >0.99). Nine biologic complications occurred in the NDI group and twelve in the SDI group (P = 0.81). Twelve prosthetic complications occurred in the NDI group and only two in the SDI group (P = 0.001). Peri-implant marginal bone loss at 5 years was 0.95 ± 0.84 mm for the NDI group and 1.2 ± 0.86 mm for the SDI group (P = 0.06). Five-year data indicate that FPD treatment in posterior mandibular and maxillary jaws with NDIs was as reliable as with SDIs, although NDIs showed a higher risk of prosthetic complications.

Visible Light-Induced Photocatalytic and Antibacterial Activity of Li-Doped Bi0.5Na0.45K0.5TiO3-BaTiO3 Ferroelectric Ceramics

NASA Astrophysics Data System (ADS)

Kushwaha, H. S.; Halder, Aditi; Jain, D.; Vaish, Rahul

2015-11-01

The visible light-active ferroelectric photocatalyst Bi0.5Na0.45Li0.05K0.5TiO3-BaTiO3 (BNKLBT) was synthesized by a solid-state method and its photocatalytic, photoelectrochemical, and antibacterial properties were investigated. In a chronoamperometric study the current density under visible light was 30 μA/cm2, which is three times more than that observed under dark conditions. The compound's visible light photocatalytic activity was investigated for degradation of an organic dye (methyl orange) and an estrogenic pollutant (estriol).The kinetic rate constants calculated for photocatalytic degradation of methyl orange and estriol were 0.007 and 0.056 min-1, respectively. High photocatalytic and photoelectrochemical activity was a result of effective separation of photo-generated charge carriers, because of the ferroelectric nature of the catalyst. The effect of different charge-trapping agents on photocatalytic degradation was studied to investigate the effect of active species and the degradation pathway. Antimicrobial activity was investigated for Escherichia coli and Aspergillus flavus. The anti-bacterial action of BNKLBT was compared with that of the commercial antibiotic kanamycin (k30).

Ocular Penetration and Anti-inflammatory Activity of Ketorolac 0.45% and Bromfenac 0.09% Against Lipopolysaccharide-Induced Inflammation

PubMed Central

Galindo, Danielle; Villanueva, Linda; Nguyen, Cathy; Patel, Milan; Borbridge, Lisa; Attar, Mayssa; Schiffman, Rhett M.; Hollander, David A.

2011-01-01

Abstract Purpose Anti-inflammatory activity of topical nonsteroidal anti-inflammatory drugs is mediated by suppression of cyclooxygenase (COX) isoenzymes. This study compared ocular penetration and inflammation suppression of topical ketorolac 0.45% and bromfenac 0.09% ophthalmic solutions in a rabbit model. Methods At hour 0, 36 rabbits received ketorolac 0.45%, bromfenac 0.09%, or an artificial tear 3 times once every 20 min. Half of the rabbits in each group then received intravenous injections of lipopolysaccharide (LPS) and fluorescein isothiocyanate (FITC)–dextran at hour 1, and the other half at hour 10. Aqueous and iris-ciliary body (ICB) samples were collected in the former group at hour 2 (peak) and in the latter group at hour 11 (trough) An additional group of 6 animals received only FITC-dextran, and samples were collected 1 h later. Peak and trough nonsteroidal anti-inflammatory drug concentrations were compared with previously determined half-maximal inhibitory concentrations (IC50) for COX isoenzymes. Results Peak and trough aqueous and ICB concentrations of ketorolac were at least 7-fold or greater than those of bromfenac. At peak levels, both ketorolac 0.45% and bromfenac 0.09% significantly inhibited LPS-induced aqueous prostaglandin E2 and FITC-dextran elevation (P < 0.01). At trough, both study drugs significantly inhibited LPS-induced aqueous prostaglandin E2 elevation (P < 0.05), but only ketorolac 0.45% significantly reduced LPS-induced aqueous FITC-dextran elevation (P < 0.01). Aqueous and ICB ketorolac concentrations exceeded its IC50 for COX-1 and COX-2 at peak and trough. Aqueous and ICB bromfenac levels exceeded its IC50 for COX-2 at peak and trough, but not for COX-1 at trough aqueous levels and peak and trough ICB levels. Conclusions Both ketorolac 0.45% and bromfenac 0.09% effectively suppressed inflammation at peak. At trough, only ketorolac 0.45% effectively suppressed inflammation as measured by FITC

45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false What capacity-building activities may AmeriCorps members perform? 2520.30 Section 2520.30 Public Welfare Regulations Relating to Public Welfare (Continued... infrastructure of the sponsoring organization, including: (i) Conducting research, mapping community assets, or...

45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false What capacity-building activities may AmeriCorps members perform? 2520.30 Section 2520.30 Public Welfare Regulations Relating to Public Welfare (Continued... infrastructure of the sponsoring organization, including: (i) Conducting research, mapping community assets, or...

The imaging 3.0 informatics scorecard.

PubMed

Kohli, Marc; Dreyer, Keith J; Geis, J Raymond

2015-04-01

Imaging 3.0 is a radiology community initiative to empower radiologists to create and demonstrate value for their patients, referring physicians, and health systems. In image-guided health care, radiologists contribute to the entire health care process, well before and after the actual examination, and out to the point at which they guide clinical decisions and affect patient outcome. Because imaging is so pervasive, radiologists who adopt Imaging 3.0 concepts in their practice can help their health care systems provide consistently high-quality care at reduced cost. By doing this, radiologists become more valuable in the new health care setting. The authors describe how informatics is critical to embracing Imaging 3.0 and present a scorecard that can be used to gauge a radiology group's informatics resources and capabilities. Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.

45 CFR 30.26 - Consideration of tax consequences to the Government.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Consideration of tax consequences to the... CLAIMS COLLECTION Debt Compromise § 30.26 Consideration of tax consequences to the Government. In negotiating a compromise, the Secretary will consider the tax consequences to the Government. In particular...

Design and Development Comparison of Rapid Cycle Amine 1.0, 2.0, and 3.0

NASA Technical Reports Server (NTRS)

Chullen, Cinda; Campbell, Colin; Papale, William; Murray, Sean; Wichowski, Robert; Conger, Bruce; McMillin, Summer

2016-01-01

The development of the Rapid Cycle Amine (RCA) swing-bed technology for carbon dioxide (CO2) removal has been in progress since favorable results were published in 1996. Shortly thereafter, a prototype was designed, developed, and tested successfully and delivered to Johnson Space Center in 1999. An improved prototype (RCA 1.0) was delivered to NASA in 2006 and sized for the extravehicular activity (EVA). The RCA swing-bed technology is a regenerative system which employs two alternating solid-amine sorbent beds to remove CO2 and water. The two-bed design employs a chemisorption process whereby the beds alternate between adsorption and desorption. This process provides for an efficient RCA operation that enables one bed to be in adsorb (uptake) mode, while the other is in the desorb (regeneration) mode. The RCA has progressed through several iterations of technology readiness levels. Test articles have now been designed, developed, and tested for the advanced space suit portable life support system (PLSS) including RCA 1.0, RCA 2.0, and RCA 3.0. The RCA 3.0 was the most recent RCA fabrication and was delivered to NASA-JSC in June 2015. The RCA 1.0 test article was designed with a pneumatically actuated linear motion spool valve. The RCA 2.0 and 3.0 test articles were designed with a valve assembly which allows for switching between uptake and regeneration modes while minimizing gas volume losses to the vacuum source. RCA 2.0 and 3.0 also include an embedded controller design to control RCA operation and provide the capability of interfacing with various sensors and other ventilation loop components. The RCA technology is low power, small, and has fulfilled all test requirements levied upon the technology during development testing thus far. This paper will provide an overview of the design and development of RCA 1.0, 2.0 and 3.0 including detail differences between the design specifications of each. Nomenclature.

Design and Development Comparison of Rapid Cycle Amine 1.0, 2.0, and 3.0

NASA Technical Reports Server (NTRS)

Chullen, Cinda; Campbell, Colin; Papale, William; Murray, Sean; Wichowski, Robert; Conger, Bruce; McMillin, Summer

2016-01-01

The development of the Rapid Cycle Amine (RCA) swing-bed technology for carbon dioxide (CO2) removal has been in progress since favorable results were published in 1996. Shortly thereafter, a prototype was designed, developed, and tested successfully and delivered to Johnson Space Center in 1999. An improved prototype was delivered to NASA in 2006 and was notated as RCA 1.0 and sized for the extravehicular activity (EVA). The new RCA swing-bed technology is a regenerative system which employs two alternating solid-amine sorbent beds to remove CO2 and water. The two- bed design employs a chemisorption process whereby the beds alternate between adsorbtion and desorbsion. This process provides for an efficient operation of the RCA so that while one bed is in adsorb (uptake) mode, the other is in the desorb (regeneration) mode. The RCA has now progressed through several iterations of technology readiness levels. Test articles have now been designed, developed, and tested for the advanced space suit portable life support system (PLSS) including RCA 1.0, RCA 2.0, and RCA 3.0. The RCA 3.0 was the most recent RCA fabrication and was delivered to NASA-JSC in June 2015. The RCA 1.0 test article was designed with a pneumatically actuated linear motion spool valve. The RCA 2.0 and 3.0 test articles were designed with a valve assembly which allows for switching between uptake and regeneration modes while minimizing gas volume losses to the vacuum source. RCA 2.0 and 3.0 also include an embedded controller design to control RCA operation and provide the capability of interfacing with various sensors and other ventilation loop components. The RCA technology is low power, small, and has fulfilled all test requirements levied upon the technology during development testing thus far. This paper will provide an overreview of the design and development of RCA 1.0, 2.0 and 3.0 including detail differences between the design specifications of each.

Towards health informatics 3.0. Editorial.

PubMed

Kulikowski, Casimir A; Geissbuhler, Antoine

2011-01-01

To provide an editorial introduction to the 2011 IMIA Yearbook of Medical Informatics with an overview of its contents and contributors. A brief overview of the main theme, and an outline of the purposes, contents, format, and acknowledgment of contributions for the 2011 IMIA Yearbook. This 2011 issue of the IMIA Yearbook highlights important developments in the development of Web 3.0 capabilities that are increasing in Health Informatics, impacting the activities in research, education and practice in this interdisciplinary field. There has been steady progress towards introducing semantics into informatics systems through more sophisticated representations of knowledge in their underlying information. Health Informatics 3.0 capabilities are identified from the recent literature, illustrated by selected papers published during the past 12 months, and articles reported by IMIA Working Groups. Surveys of the main research sub-fields in biomedical informatics in the Yearbook provide an overview of progress and current challenges across the spectrum of the discipline, focusing on Web 3.0 challenges and opportunities.

A biomechanical study of laparoscopic 4S-modified Roeder and Weston knot strength in 3-0 polyglactin 910 and 3-0 polydioxanone.

PubMed

Fugazzi, Russell W; Fransson, Boel A; Curran, Katie M; Davis, Howard M; Gay, John M

2013-02-01

To (1) evaluate biomechanical strength of 4 different laparoscopic knots using 2 suture types, and (2) evaluate carotid artery ligature bursting pressure of 2 knots using a single suture type. Biomechanical materials testing. Suture material (3-0 polydioxanone, 3-0 polyglactin 910). Four knot types were tested: 4S-modified Roeder (4SMR) Weston plus 3 square throws (W3S); Weston plus 3 granny throws (W3G); and a 4 square throw knot as a control (control); 24 specimens of each knot type were tied with 3-0 polyglactin 910 and 24 of 3 knot types (4SMR, W3S, control) were tied with 3-0 polydioxanone. Suture loop constructs were tested to 3 mm displacement failure and ultimate failure. Carotid artery ligation bursting pressure was tested using 10 samples each of 4SMR and W3S knots with 3-0 polyglactin 910. The W3S, W3G, and controls were similar. The 4SMR was similar to W3S using 3-0 PDS but the 4SMR had lower load to failure and greater elongation than the Weston using 3-0 polyglactin 910. The 4SMR had a higher slippage rate with 3-0 polyglactin 910. All ligatures withstood supraphysiologic pressures. Surgeons using 3-0 polyglactin 910 should consider using the Weston knot with added throws during laparoscopic procedures. © Copyright 2012 by The American College of Veterinary Surgeons.

Social Values for Ecosystem Services, version 3.0 (SolVES 3.0): documentation and user manual

USGS Publications Warehouse

Sherrouse, Ben C.; Semmens, Darius J.

2015-01-01

The geographic information system (GIS) tool, Social Values for Ecosystem Services (SolVES), was developed to incorporate quantified and spatially explicit measures of social values into ecosystem service assessments. SolVES 3.0 continues to extend the functionality of SolVES, which was designed to assess, map, and quantify the social values of ecosystem services. Social values—the perceived, nonmarket values the public ascribes to ecosystem services, particularly cultural services, such as aesthetics and recreation—can be evaluated for various stakeholder groups. These groups are distinguishable by their attitudes and preferences regarding public uses, such as motorized recreation and logging. As with previous versions, SolVES 3.0 derives a quantitative 10-point, social-values metric—the value index—from a combination of spatial and nonspatial responses to public value and preference surveys. The tool also calculates metrics characterizing the underlying environment, such as average distance to water and dominant landcover. SolVES 3.0 is integrated with Maxent maximum entropy modeling software to generate more complete social-value maps and offer robust statistical models describing the relationship between the value index and explanatory environmental variables. A model’s goodness of fit to a primary study area and its potential performance in transferring social values to similar areas using value-transfer methodology can be evaluated. SolVES 3.0 provides an improved public-domain tool for decision makers and researchers to evaluate the social values of ecosystem services and to facilitate discussions among diverse stakeholders regarding the tradeoffs among ecosystem services in a variety of physical and social contexts ranging from forest and rangeland to coastal and marine.

Radiofrequency heating and magnetically induced displacement of dental magnetic attachments during 3.0 T MRI

PubMed Central

Miyata, K; Hasegawa, M; Abe, Y; Tabuchi, T; Namiki, T; Ishigami, T

2012-01-01

Objective The aim of this study was to estimate the risk of injury from dental magnetic attachments due to their radiofrequency (RF) heating and magnetically induced displacement during 3.0 T MRI. Methods To examine the magnetic attachments, we adopted the American Society for Testing and Materials F2182-02a and F2052-06 standards in two MRI systems (Achieva 3.0 T Nova Dual; Philips, Tokyo, Japan, and Signa HDxt 3.0 T; GE Healthcare, Milwaukee, WI). The temperature change was measured in a cylindrical keeper (GIGAUSS D600; GC, Tokyo, Japan) with coping of the casting alloy and a keeper with a dental implant at the maximum specific absorption rate (SAR) for 20 min. To measure the magnetically induced displacement force, three sizes of keepers (GIGAUSS D400, D600 and D1000) were used in deflection angle tests conducted at the point of the maximum magnetic field strength. Results Temperature elevations of both coping and implant were higher in the Signa system than in the Achieva system. The highest temperature changes in the keeper with implant and keeper with coping were 0.6 °C and 0.8 °C in the Signa system, respectively. The temperature increase did not exceed 1.0 °C at any location. The deflection angle (α) was not measurable because it exceeded 90°. GIGAUSS D400 required an extra 3.0 g load to constrain the deflection angle to less than 45°; GIGAUSS D600 and D1000 required 5.0 and 9.0 g loads, respectively. Conclusions Dental magnetic attachments pose no risk due to RF heating and magnetically induced displacement at 3.0 T MRI. However, it is necessary to confirm that these keepers are securely attached to the prosthesis before imaging. PMID:22499128

Porous Ni0.1Mn0.9O1.45 microellipsoids as high-performance anode electrocatalyst for microbial fuel cells.

PubMed

Zeng, Lizhen; Zhang, Wenguang; Xia, Pan; Tu, Wenqiang; Ye, Changchun; He, Miao

2018-04-15

A novel bi-component composite of porous self-assembled micro-/nanostructured Ni 0.1 Mn 0.9 O 1.45 microellipsoids as high-performance anode electrocatalyst for microbial fuel cells (MFCs) is successfully synthesized via a simple coprecipitation reaction in microemulsion and calcination method in air atmosphere. The morphology and structural characterization indicate that the as-fabricated Ni 0.1 Mn 0.9 O 1.45 product is consist of Mn 2 O 3 and NiMn 2 O 4 (n(Mn 2 O 3) : n(NiMn 2 O 4 ) = 0.35: 0.1) and has a porous microellipsoidal morphology. The microellipsoids are compose of numerous layered micro-/nanostructured blocks and the special porous microellipsoids structure of Ni 0.1 Mn 0.9 O 1.45 offers a large specific surface area for bacteria adhesion. The porous Ni 0.1 Mn 0.9 O 1.45 microellipsoids as anode electrocatalyst for MFCs exhibits excellent electrocatalytic activity to promote the extracellular electron transfer (EET) between the anode and bacteria, hence improves the performance of MFC. The MFC equipped with Ni 0.1 Mn 0.9 O 1.45 /CF anode achieves a maximum power density of 1.39 ± 0.02Wm -2 , is significantly higher than that of commercial carbon felt anode. This work proposes a new method for the synthesis of high-performance and environmentally friendly anode electrocatalyst for MFCs. Copyright © 2017 Elsevier B.V. All rights reserved.

Web 3.0: Implications for Online Learning

ERIC Educational Resources Information Center

Morris, Robin D.

2010-01-01

The impact of Web 3.0, also known as the Semantic Web, on online learning is yet to be determined as the Semantic Web and its technologies continue to develop. Online instructors must have a rudimentary understanding of Web 3.0 to prepare for the next phase of online learning. This paper provides an understandable definition of the Semantic Web…

Montage Version 3.0

NASA Technical Reports Server (NTRS)

Jacob, Joseph; Katz, Daniel; Prince, Thomas; Berriman, Graham; Good, John; Laity, Anastasia

2006-01-01

The final version (3.0) of the Montage software has been released. To recapitulate from previous NASA Tech Briefs articles about Montage: This software generates custom, science-grade mosaics of astronomical images on demand from input files that comply with the Flexible Image Transport System (FITS) standard and contain image data registered on projections that comply with the World Coordinate System (WCS) standards. This software can be executed on single-processor computers, multi-processor computers, and such networks of geographically dispersed computers as the National Science Foundation s TeraGrid or NASA s Information Power Grid. The primary advantage of running Montage in a grid environment is that computations can be done on a remote supercomputer for efficiency. Multiple computers at different sites can be used for different parts of a computation a significant advantage in cases of computations for large mosaics that demand more processor time than is available at any one site. Version 3.0 incorporates several improvements over prior versions. The most significant improvement is that this version is accessible to scientists located anywhere, through operational Web services that provide access to data from several large astronomical surveys and construct mosaics on either local workstations or remote computational grids as needed.

Planar Ohmic Contacts to Al 0.45 Ga 0.55 N/Al 0.3 Ga 0.7 N High Electron Mobility Transistors

DOE PAGES

Klein, Brianna A.; Baca, Albert G.; Armstrong, Andrew M.; ...

2017-09-23

Here, we present a low resistance, straightforward planar ohmic contact for Al 0.45Ga 0.55N/Al 0.3Ga 0.7N high electron mobility transistors. Five metal stacks (a/Al/b/Au; a = Ti, Zr, V, Nb/Ti; b = Ni, Mo, V) were evaluated at three individual annealing temperatures (850, 900, and 950°C). The Ti/Al/Ni/Au achieved the lowest specific contact resistance at a 900°C anneal temperature. Transmission electron microscopy analysis revealed a metal-semiconductor interface of Ti-Al-Au for an ohmic (900°C anneal) and a Schottky (850°C anneal) Ti/Al/Ni/Au stack. HEMTs were fabricated using the optimized recipe with resulting contacts that had room-temperature specific contact resistances of ρ c = 2.5 × 10 -5 Ω cm², sheet resistances of R SH = 3.9 kΩ/more » $$\\blacksquare$$, and maximum current densities of 75 mA/mm (at VGATE of 2 V). Electrical measurements from -50 to 200°C had decreasing specific contact resistance and increasing sheet resistance, with increasing temperature. These contacts enabled state-of-the-art performance of Al 0.45Ga 0.55N/Al 0.3Ga 0.7N HEMTs.« less

Planar Ohmic Contacts to Al 0.45 Ga 0.55 N/Al 0.3 Ga 0.7 N High Electron Mobility Transistors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klein, Brianna A.; Baca, Albert G.; Armstrong, Andrew M.

Here, we present a low resistance, straightforward planar ohmic contact for Al 0.45Ga 0.55N/Al 0.3Ga 0.7N high electron mobility transistors. Five metal stacks (a/Al/b/Au; a = Ti, Zr, V, Nb/Ti; b = Ni, Mo, V) were evaluated at three individual annealing temperatures (850, 900, and 950°C). The Ti/Al/Ni/Au achieved the lowest specific contact resistance at a 900°C anneal temperature. Transmission electron microscopy analysis revealed a metal-semiconductor interface of Ti-Al-Au for an ohmic (900°C anneal) and a Schottky (850°C anneal) Ti/Al/Ni/Au stack. HEMTs were fabricated using the optimized recipe with resulting contacts that had room-temperature specific contact resistances of ρ c = 2.5 × 10 -5 Ω cm², sheet resistances of R SH = 3.9 kΩ/more » $$\\blacksquare$$, and maximum current densities of 75 mA/mm (at VGATE of 2 V). Electrical measurements from -50 to 200°C had decreasing specific contact resistance and increasing sheet resistance, with increasing temperature. These contacts enabled state-of-the-art performance of Al 0.45Ga 0.55N/Al 0.3Ga 0.7N HEMTs.« less

CIFO 3.0

NASA Technical Reports Server (NTRS)

Rogers, Pat

1992-01-01

The Ada Runtime Environment Working Group has, since 1985, developed and published the Catalog of Interface Features and Options (CFIO) for Ada runtime environments. These interfaces, expressed in legal Ada, provide 'hooks' into the runtime system to export both functionality and enhanced performance beyond that of 'vanilla' Ada implementations. Such enhancements include high- and low-level scheduling control, asynchronous communications facilities, predictable storage management facilities, and fast interrupt response. CIFO 3.0 represents the latest release, which incorporates the efforts of the European real time community as well as new interfaces and expansions of previous catalog entries. This presentation will give both an overview of the Catalog's contents and an 'insider's' view of the Catalog as a whole.

Study on Dy0.45Ba0.05Sr0.5Co0.8Fe0.2O3-δ-Ce0.85Gd0.15O1.95 composite cathode material for intermediate temperature solid oxide fuel cell

NASA Astrophysics Data System (ADS)

Kautkar, Pranay R.; Acharya, Smita A.

2018-05-01

xDy0.45Ba0.05Sr0.5Co0.8Fe0.2O3-δ - xCe0.85Gd0.15O1.95 (x = 50 %) composite cathode supported on Ce0.85Gd0.15O1.95 (GDC15) electrolyte are studied for applications in IT-SOFCs. Results attribute that Dy0.45Ba0.05Sr0.5Co0.8Fe0.2O3-δ material is chemically compatible with Ce0.85Gd0.15O1.95 (GDC15). Rietveld refined X-ray diffraction patterns notify orthorhombic (space group:Pbnm) symmetry for Dy0.45 Ba0.05Sr0.5Co0.8Fe0.2O3-δ and fluorite type structure (space group: Fm-3m) symmetry for GDC15. The polarization resistance (Rp) of composite cathode reduces to the minimum value of 1.35 Ω cm2 at 650 °C in air. Area specific resistance (ASR) of composite cathode has found 0.67 Ω.cm2 at 650°C respectively. Result shows that the surface diffusion of the dissociative adsorbed oxygen at electrode/electrolyte interface on the composite cathode.

IT infrastructure in the era of imaging 3.0.

PubMed

McGinty, Geraldine B; Allen, Bibb; Geis, J Raymond; Wald, Christoph

2014-12-01

Imaging 3.0 is a blueprint for the future of radiology modeled after the description of Web 3.0 as "more connected, more open, and more intelligent." Imaging 3.0 involves radiologists' using their expertise to manage all aspects of imaging care to improve patient safety and outcomes and to deliver high-value care. IT tools are critical elements and drivers of success as radiologists embrace the concepts of Imaging 3.0. Organized radiology, specifically the ACR, is the natural convener and resource for the development of this Imaging 3.0 toolkit. The ACR's new Imaging 3.0 Informatics Committee is actively working to develop the informatics tools radiologists need to improve efficiency, deliver more value, and provide quantitative ways to demonstrate their value in new health care delivery and payment systems. This article takes each step of the process of delivering high-value Imaging 3.0 care and outlines the tools available as well as additional resources available to support practicing radiologists. From the moment when imaging is considered through the delivery of a meaningful and actionable report that is communicated to the referring clinician and, when appropriate, to the patient, Imaging 3.0 IT tools will enable radiologists to position themselves as vital constituents in cost-effective, high-value health care. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

31 CFR 30.0 - Executive compensation and corporate governance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Executive compensation and corporate governance. 30.0 Section 30.0 Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.0 Executive compensation and corporate governance...

8 CFR 3.0 - Executive Office for Immigration Review

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Executive Office for Immigration Review 3.0 Section 3.0 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW § 3.0 Executive Office for Immigration Review Regulations of the Executive Office for...

Comparison of ketorolac 0.45% versus diclofenac 0.1% for macular thickness and volume after uncomplicated cataract surgery.

PubMed

Lee, Tae Hee; Choi, Won; Ji, Yong Sok; Yoon, Kyung Chul

2016-05-01

To compare the effects of ketorolac 0.45% and diclofenac 0.1% on macular thickness and volume after uncomplicated cataract surgery. A total of 76 eyes of 76 patients who underwent uncomplicated cataract surgery were included. Patients were treated with either diclofenac 0.1% (38 eyes) or ketorolac 0.45% (38 eyes) after surgery. The macular thickness and volume were obtained with optical coherence tomography (OCT). Central subfield thickness (CST, OCT 1 mm zone), total foveal thickness (TFT, OCT 3 mm zone), total macular thickness (TMT, OCT 6 mm zone), average macular thickness (AMT) and total macular volume (TMV) were compared between the two study groups. No significant differences between groups were found in macular thickness or volume 1 month after cataract surgery. Two months after surgery, the ketorolac group had significantly lower CST, TFT, TMT and AMT than the diclofenac group (p < 0.05 for all). Additionally, 1 and 2 months after surgery, changes from preoperative values in CST (both p = 0.04), AMT (p = 0.02 and p < 0.01, respectively) and TMV (both p = 0.04) were significantly less in the ketorolac group than in the diclofenac group. Following uncomplicated cataract surgery, topical ketorolac 0.45% was more effective than diclofenac 0.1% in preventing increases in macular thickness and volume. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

15 CFR 30.45 - General statement of requirements for the filing of carrier manifests with proof of filing...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false General statement of requirements for the filing of carrier manifests with proof of filing citations for the electronic submission of export information or exemption legends when Electronic Export Information filing is not required. 30.45 Section 30.45 Commerce and Foreign Trade...

45 CFR 30.13 - Debt reporting and use of credit reporting agencies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Debt reporting and use of credit reporting... CLAIMS COLLECTION Standards for the Administrative Collection of Debts § 30.13 Debt reporting and use of... over $100 to credit bureaus or other automated databases. Debts arising under the Social Security Act...

Evaluation of wind tunnel performance testings of an advanced 45 deg swept 8-bladed propeller at Mach numbers from 0.45 to 0.85

NASA Technical Reports Server (NTRS)

Rohrbach, C.; Metzger, F. B.; Black, D. M.; Ladden, R. M.

1982-01-01

The increased emphasis of fuel conservation in the world and the rapid increase in the cost of jet fuel has stimulated a series of studies of both conventional and unconventional propulsion systems for commercial aircraft. The results of these studies indicate that a fuel saving of 15 to 30 percent may be realized by the use of an advanced high-speed turboprop (Prop-Fan) compared to aircraft equipped with high bypass turbofan engines of equivalent technology. The Prop-Fan propulsion system is being investigated as part of the NASA Aircraft Energy Efficient Program. This effort includes the wind tunnel testing of a series of 8 and 10-blade Prop-Fan models incorporate swept blades. Test results indicate efficiency levels near the goal of 80 percent at Mach 0.8 cruise and an altitude of 10.67 km (35,000 ft). Each successive swept model has shown improved efficiency relative to the straight blade model. The fourth model, with 45 deg swept blades reported herein, shows a net efficiency of 78.2 at the design point with a power loading of 301 kW/sq meter and a tip speed of 243.8 m/sec (800 ft/sec.).

Fatigue of graphite/epoxy /0/90/45/-45/s laminates under dual stress levels

NASA Technical Reports Server (NTRS)

Yang, J. N.; Jones, D. L.

1982-01-01

A model for the prediction of loading sequence effects on the statistical distribution of fatigue life and residual strength in composite materials is generalized and applied to (0/90/45/-45)s graphite/epoxy laminates. Load sequence effects are found to be caused by both the difference in residual strength when failure occurs (boundary effect) and the effect of previously applied loads (memory effect). The model allows the isolation of these two effects, and the estimation of memory effect magnitudes under dual fatigue loading levels. It is shown that the material memory effect is insignificant, and that correlations between predictions of the number of early failures agree with the verification tests, as do predictions of fatigue life and residual strength degradation under dual stress levels.

45 CFR 301.0 - Scope and applicability of this part.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true Scope and applicability of this part. 301.0 Section 301.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD... deals with the administration of title IV-D of the Social Security Act by the Federal Government...

Magnetic resonance spectroscopy of the canine brain at 3.0 T and 7.0 T.

PubMed

Martin-Vaquero, Paula; da Costa, Ronaldo C; Echandi, Rita L; Sammet, Christina L; Knopp, Michael V; Sammet, Steffen

2012-08-01

The purpose of this study was to evaluate the feasibility of proton magnetic resonance spectroscopy (1H MRS) to study the concentration of metabolites in the brain of dogs at 3.0 and 7.0 T. Four healthy male beagles were scanned using 3.0 T and 7.0 T human magnetic resonance imaging (MRI) units. The results obtained showed that all dogs had excellent quality spectra for a small (1 cm3) and large (8 cm3) voxel at 3.0 T, whereas only 2 dogs had high quality spectra at 7.0 T due to insufficient water suppression. 1H MRS at 3.0 T appears to be a reliable method to study metabolite concentrations in the canine brain. The development of more advanced water suppression techniques is necessary to improve the results at 7.0 T. Copyright © 2011 Elsevier Ltd. All rights reserved.

76 FR 82291 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

... 12/30/11. Docket Numbers: ER12-21-002. Applicants: Agua Caliente Solar, LLC. Description: Notice of Change in Status and Request for Expedited Action of Agua Caliente Solar, LLC. Filed Date: 12/20/11...

Rapid Cycle Amine (RCA) 3.0 System Development

NASA Technical Reports Server (NTRS)

Chullen, Cinda; Campbell, Colin; Papale, William; Hawes, Kevin; Wichowski, Robert

2015-01-01

The Rapid Cycle Amine (RCA) 3.0 system is currently under development by NASA, the Lyndon B. Johnson Space Center (JSC) in conjunction with United Technologies Corporation Aerospace Systems (UTAS). The RCA technology is a new carbon dioxide (CO2) and humidity removal system that has been baselined for the Advanced Extravehicular Mobility Unit (AEMU) Portable Life Support System. The evolution of the RCA development has progressed through several iterations of technology readiness levels including RCA 1.0, RCA 2.0, and RCA 3.0 test articles. The RCA is an advancement over currently technologies due to its unique regeneration capability. The RCA is capable of simultaneously removing CO2 and humidity from an influent air steam and subsequent regeneration when exposed to a vacuum source. The RCA technology uses two solid amine sorbent beds in an alternating fashion to adsorb CO2 and water (uptake mode) and desorb CO2 and water (regeneration mode) at the same time. The two beds operate in an efficient manner so that while one bed is in the uptake mode, the other is in the regeneration mode, thus continuously providing an on-service sorbent bed by which CO2 and humidity may be removed. The RCA 2.0 and 3.0 test articles were designed with a novel valve assembly which allows for switching between uptake and regeneration modes with only one moving part while minimizing gas volume losses to the vacuum source by means of an internal pressure equalization step during actuation. The RCA technology also is low power, small, and has performed extremely well in all development testing thus far. A final design was selected for the RCA 3.0, fabricated, assembled, and performance tested in 2014 with delivery to NASAJSC in January 2015. This paper will provide an overview on the RCA 3.0 system design and results of pre-delivery testing with references to the development of RCA 1.0 and RCA 2.0.

45 CFR 1355.30 - Other applicable regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Sharing or Matching, and (2) section 74.52 Financial Reporting Requirements, will not apply.) (d) 45 CFR... Federal Financial Assistance. (h) 45 CFR Part 91—Nondiscrimination on the Basis of Age in HHS Programs or Activities Receiving Federal Financial Assistance. (i) 45 CFR Part 92—Uniform Administrative Requirements for...

OpenGov Plan 3.0 Outline

EPA Pesticide Factsheets

This document serves as an outline for the structure of the Agency’s Open Government Plan 3.0, expected to be published later this summer, along with a description of a candidate being consider as a flagship project.

Structural, morphological and optical properties of LiCo0.5Ni0.45Ag0.05O2 thin films

NASA Astrophysics Data System (ADS)

Haider, Adawiya J.; AL-Rsool, Rusul Abed; AL-Tabbakh, Ahmed A.; Al-Gebori, Abdul Nasser M.; Mohamed, Aliaa

2018-05-01

Pulsed Laser Deposition (PLD) method has been successfully used for the synthesized of nano-crystalline cathode m aterial LiCo0.5Ni0.45Ag0.05O2 (LCNAO) thin film. LCNAO Ferromagnetic using pulsed Nd-YAG laser with wavelength (λ = 532 nm) and duration (10 ns) and energy fluence (1.4 J/cm2) with different substrate temperature (100, 200, 300) ˚C and O2 pressure at 10 mbar. The structural, morphological and optical properties of the films were determined by X-ray Diffraction (XRD), Scan Electron Microscopy (SEM), Atomic Force microscope (AFM) and UV-VIS spectroscopy respectively. It is observed that partial layer to spinel transformation takes place during post annealing and the average particle size of the LiCo0.5Ni0.45Ag0.05O2 is found to be (1-12) nm from SEM measurement. Finally the optical properties of the thin films have been studied at different Substrate temperature. It found the energy gap decreases from 4.2 to 3.8 eV when the substrate's temperature increasing from 100° C into 300 °C of the LCNAO films. These mean that the optical quality of LCNAO films is improved due to the increase in crystalline size and reduction of defect sites.

Essentials of MDS 3.0 section M: skin conditions.

PubMed

Levine, Jeffrey M; Roberson, Sharon; Ayello, Elizabeth A

2010-06-01

To provide information about the impending changes in the Minimum Data Set (MDS) Section M on skin conditions and its implications for practice. This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. After participating in this educational activity, the participant should be better able to: 1. Compare section M of MDS version 2.0 to MDS version 3.0. 2. Apply the complexities of the MDS 3.0 section M for coding. 3. Demonstrate accurate and complete documentation of wounds as per MDS 3.0 section M.

Exceptional cracking behavior in H-implanted Si/B-doped Si0.70Ge0.30/Si heterostructures

NASA Astrophysics Data System (ADS)

Chen, Da; Wang, Dadi; Chang, Yongwei; Li, Ya; Ding, Rui; Li, Jiurong; Chen, Xiao; Wang, Gang; Guo, Qinglei

2018-01-01

The cracking behavior in H-implanted Si/B-doped Si0.70Ge0.30/Si structures after thermal annealing was investigated. The crack formation position is found to closely correlate with the thickness of the buried Si0.70Ge0.30 layer. For H-implanted Si containing a buried 3-nm-thick B-doped Si0.70Ge0.30 layer, localized continuous cracking occurs at the interfaces on both sides of the Si0.70Ge0.30 interlayer. Once the thickness of the buried Si0.70Ge0.30 layer increases to 15 and 70 nm, however, a continuous sharp crack is individually observed along the interface between the Si substrate and the B-doped Si0.70Ge0.30 interlayer. We attribute this exceptional cracking behavior to the existence of shear stress on both sides of the buried Si0.70Ge0.30 layer and the subsequent trapping of hydrogen, which leads to a crack in a well-controlled manner. This work may pave the way for high-quality Si or SiGe membrane transfer in a feasible manner, thus expediting its potential applications to ultrathin silicon-on-insulator (SOI) or silicon-germanium-on-insulator (SGOI) production.

Design of an LVDS to USB3.0 adapter and application

NASA Astrophysics Data System (ADS)

Qiu, Xiaohan; Wang, Yu; Zhao, Xin; Chang, Zhen; Zhang, Quan; Tian, Yuze; Zhang, Yunyi; Lin, Fang; Liu, Wenqing

2016-10-01

USB 3.0 specification was published in 2008. With the development of technology, USB 3.0 is becoming popular. LVDS(Low Voltage Differential Signaling) to USB 3.0 Adapter connects the communication port of spectrometer device and the USB 3.0 port of a computer, and converts the output of an LVDS spectrometer device data to USB. In order to adapt to the changing and developing of technology, LVDS to USB3.0 Adapter was designed and developed based on LVDS to USB2.0 Adapter. The CYUSB3014, a new generation of USB bus interface chip produced by Cypress and conforming to USB3.0 communication protocol, utilizes GPIF-II (GPIF, general programmable interface) to connect the FPGA and increases effective communication speed to 2Gbps. Therefore, the adapter, based on USB3.0 technology, is able to connect more spectrometers to single computer and provides technical basis for the development of the higher speed industrial camera. This article describes the design and development process of the LVDS to USB3.0 adapter.

Frequency dependent electrical characteristics of ferroelectric Pb{4.0}K{1.0}Li{1.0}Nb{10}O{30} ceramics

NASA Astrophysics Data System (ADS)

Rao, K. S.; Krishna, P. M.; Prasad, D. M.; Latha, T. S.; Hussain, M.

2007-09-01

Dielectric, impedance, modulus and conductivity studies were performed over temperature 35 °C 600 °C and frequency 45 Hz 5 MHz range on the Lead Potassium Lithium Niobate (Pb{4.0}K{1.0}Li{1.0}Nb{10}O{30}, PKLN) ceramics. These studies established the conduction ion motion and polarization mechanism in the material. The dispersive dielectric loss at high temperature reveals the ionic conductivity. From frequency variation of \\varepsilonl response the pre-factor A(T) and critical exponent n(T) are evaluated, and are used in Jonscher's dielectric dispersion relation for \\varepsilon ' to fit with the experimental data. Complex impedance plots showed a non Debye type relaxation, are used to evaluate the grain and grain boundary conduction and relaxation activation energies. DC and ac conduction activation energies are estimated from Arrhenius plots. Occupancy of Li+ for C-sites gave a completely filled structure and enhanced the phase transition temperature to 520 °C compared to PKN. This is supported by the conduction activation energy in ferro region is more than the para region. Also, the dc conductivity characterized from bulk resistance and M^ll peak frequency. Polaron hoping mechanism at room temperature has been confirmed via the linear variation of the plot log (σ ac-σ dc) as a function of log ω 2. Stretched exponential parameter, β (0 < β ≤slant 1) has been evaluated from impedance plots, interpreted as a result of correlated motions between the Li+ ions and distribution of dielectric relaxation. Compared the results from different techniques, and discussed the conduction mechanism in the material.

Description and Evaluation of GDEM-V 3.0

DTIC Science & Technology

2009-02-06

Description and Evaluation of GDEM -V 3.0 Michael R. caRnes Ocean Sciences Branch Oceanography Division February 6, 2009 i REPORT DOCUMENTATION PAGE Form...include area code) b. ABSTRACT c. THIS PAGE 18. NUMBER OF PAGES 17. LIMITATION OF ABSTRACT Description and Evaluation of GDEM -V 3.0 Michael R. Carnes...unlimited. Unclassified Unclassified Unclassified UL 24 Michael R. Carnes (228) 688-5648 The GDEM (Generalized Digital Environment Model) has served as

Uranus' (3-0) H2 quadrupole line profiles

NASA Technical Reports Server (NTRS)

Trafton, L.

1987-01-01

Spectra of Uranus' S3(0) and S3(1) H2 quadrupole lines, obtained during the 1978-1980 apparitions, are analyzed, and are found to require the presence of a deep cloud. Modifications of the Baines and Bergstralh (1986) standard model, including an additional haze layer above the 16-km-am H2 level which contains strongly absorbing particles, are needed to fit the observations. For a Rayleigh phase function, such a haze (uniformly mixed with the gas above this level) would have an absorption optical depth of 0.16 and a single scattering particle albedo of 0.30. This modification would imply a fraction of normal H2 equal to 0.25 + or - 0.10, in agreement with the Baines and Bergstralh standard model.

Central Solar Eclipses of 1992. Annual Solar Eclipse of 4-5 January 1992, Total Solar Eclipse of 30 June 1992

DTIC Science & Technology

1991-02-01

January 4d 23 h 14𔃺 42’.825 Julian Date = 2448626.4685512127 It mn s s R.A. of Sun and Moon 1900 11.850 Hourly motions 10.995 and 126.011 AT 58.577...geocentric conjunction in right ascension, June 3 0 d 12 h 23m 21’.929 Julian Date = 2448804.0162260344 h m s s s R.A. of Sun and Moon 6 38 57.402 Hourly...98.6 0.983 A 60 -31 45.0 - 52 20.0 Pelotas 10 59 38.6 97.7 0.974 5 59 -30 03.2 - 51 07.6 Porto Alegre (Morro Santana Obs.) 10 58 42.3 94.3 0.946 6 59

Superconductivity with twofold symmetry in Bi2Te3/FeTe0.55Se0.45 heterostructures.

PubMed

Chen, Mingyang; Chen, Xiaoyu; Yang, Huan; Du, Zengyi; Wen, Hai-Hu

2018-06-01

Topological superconductors are an interesting and frontier topic in condensed matter physics. In the superconducting state, an order parameter will be established with the basic or subsidiary symmetry of the crystalline lattice. In doped Bi 2 Se 3 or Bi 2 Te 3 with a basic threefold symmetry, it was predicted, however, that bulk superconductivity with order parameters of twofold symmetry may exist because of the presence of odd parity. We report the proximity effect-induced superconductivity in the Bi 2 Te 3 thin film on top of the iron-based superconductor FeTe 0.55 Se 0.45 . By using the quasiparticle interference technique, we demonstrate clear evidence of twofold symmetry of the superconducting gap. The gap minimum is along one of the main crystalline axes following the so-called Δ 4 y notation. This is also accompanied by the elongated vortex shape mapped out by the density of states within the superconducting gap. Our results provide an easily accessible platform for investigating possible topological superconductivity in Bi 2 Te 3 /FeTe 0.55 Se 0.45 heterostructures.

Superconductivity with twofold symmetry in Bi2Te3/FeTe0.55Se0.45 heterostructures

PubMed Central

Du, Zengyi

2018-01-01

Topological superconductors are an interesting and frontier topic in condensed matter physics. In the superconducting state, an order parameter will be established with the basic or subsidiary symmetry of the crystalline lattice. In doped Bi2Se3 or Bi2Te3 with a basic threefold symmetry, it was predicted, however, that bulk superconductivity with order parameters of twofold symmetry may exist because of the presence of odd parity. We report the proximity effect–induced superconductivity in the Bi2Te3 thin film on top of the iron-based superconductor FeTe0.55Se0.45. By using the quasiparticle interference technique, we demonstrate clear evidence of twofold symmetry of the superconducting gap. The gap minimum is along one of the main crystalline axes following the so-called Δ4y notation. This is also accompanied by the elongated vortex shape mapped out by the density of states within the superconducting gap. Our results provide an easily accessible platform for investigating possible topological superconductivity in Bi2Te3/FeTe0.55Se0.45 heterostructures. PMID:29888330

Letter Report: Yucca Mountain Environmental Monitoring Systems Initiative - Air Quality Scoping Study for Caliente, Lincoln County, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. Englebrecht; I. Kavouras; D. Campbell

2008-08-01

The Desert Research Institute (DRI) is performing a scoping study as part of the U.S. Department of Energy's Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at eight sites outside the NTS, including Ash Meadows National Wildlife Refuge (NWR), Beatty, Sarcobatus Flats, Rachel, Caliente, Pahranagat NWR, Crater Flat, and Tonopah Airport, and at four sites on the NTS (Engelbrecht et al., 2007a-d).more » The trailer is stationed at any one site for approximately eight weeks at a time. This letter report provides a summary of air quality and meteorological data, on completion of the site's sampling program.« less

0.5-45GHz Simultaneous Transmit and Receive (STAR) Antenna System for Electronic Attack

DTIC Science & Technology

2016-03-17

0.5-45GHz Simultaneous Transmit and Receive (STAR) Antenna System for Electronic Attack Mohamed Elmansouri, Prathap Valaleprasannakumar, Elie...Colorado, US, 80309 Abstract: A shared antenna aperture for simultaneous transmit and receive (STAR) operating from 0.5 to 45GHz with isolation...50dB over the entire band is discussed. The co-located antenna aperture system is designed across 4 overlapping bands: 0.5-2.5GHz, 2-7GHz, 6-19GHz

Validation Results for LEWICE 3.0

NASA Technical Reports Server (NTRS)

Wright, William B.

2005-01-01

A research project is underway at NASA Glenn to produce computer software that can accurately predict ice growth under any meteorological conditions for any aircraft surface. This report will present results from version 3.0 of this software, which is called LEWICE. This version differs from previous releases in that it incorporates additional thermal analysis capabilities, a pneumatic boot model, interfaces to computational fluid dynamics (CFD) flow solvers and has an empirical model for the supercooled large droplet (SLD) regime. An extensive comparison of the results in a quantifiable manner against the database of ice shapes and collection efficiency that have been generated in the NASA Glenn Icing Research Tunnel (IRT) has also been performed. The complete set of data used for this comparison will eventually be available in a contractor report. This paper will show the differences in collection efficiency between LEWICE 3.0 and experimental data. Due to the large amount of validation data available, a separate report is planned for ice shape comparison. This report will first describe the LEWICE 3.0 model for water collection. A semi-empirical approach was used to incorporate first order physical effects of large droplet phenomena into icing software. Comparisons are then made to every single element two-dimensional case in the water collection database. Each condition was run using the following five assumptions: 1) potential flow, no splashing; 2) potential flow, no splashing with 21 bin drop size distributions and a lift correction (angle of attack adjustment); 3) potential flow, with splashing; 4) Navier-Stokes, no splashing; and 5) Navier-Stokes, with splashing. Quantitative comparisons are shown for impingement limit, maximum water catch, and total collection efficiency. The results show that the predicted results are within the accuracy limits of the experimental data for the majority of cases.

Vertical Bridgman growth and characterization of Cd 0.95-xMn xZn 0.05Te (x=0.20, 0.30) single-crystal ingots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bolotnikov, A.; Kopach, V.; Kopach, O.

Solid-liquid phase transitions in Cd 0.95-xMn xZn 0.05Te alloys with x = 0.20 and 0.30 were investigated by differential thermal analysis (DTA). The heating/cooling rates were 5 and 10 K/min with a melt dwell time of 10, 30 and 60 minutes. Cd 0.95-xMn xZn 0.05Te (x=0.20, 0.30) single-crystal ingots were grown by the vertical Bridgman method guided using the DTA results. Te inclusions (1-20 microns), typical for CdTe and Cd(Zn)Te crystals, were observed in the ingots by infrared transmission microscopy. The measured X-ray diffraction patterns showed that all compositions are found to be in a single phase. Using current-voltage (I-V)more » measurements, the resistivity of the samples from each ingot was estimated to be about 10 5 Ohm·cm. The optical transmission analysis demonstrated that the band-gap width of the investigated ingots increased from 1.77 to 1.88 eV with the increase of the MnTe content from 20 to 30 mol. %.« less

Agua Caliente Wind/Solar Project at Whitewater Ranch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hooks, Todd; Stewart, Royce

2014-12-16

Agua Caliente Band of Cahuilla Indians (ACBCI) was awarded a grant by the Department of Energy (DOE) to study the feasibility of a wind and/or solar renewable energy project at the Whitewater Ranch (WWR) property of ACBCI. Red Mountain Energy Partners (RMEP) was engaged to conduct the study. The ACBCI tribal lands in the Coachella Valley have very rich renewable energy resources. The tribe has undertaken several studies to more fully understand the options available to them if they were to move forward with one or more renewable energy projects. With respect to the resources, the WWR property clearly hasmore » excellent wind and solar resources. The DOE National Renewable Energy Laboratory (NREL) has continued to upgrade and refine their library of resource maps. The newer, more precise maps quantify the resources as among the best in the world. The wind and solar technology available for deployment is also being improved. Both are reducing their costs to the point of being at or below the costs of fossil fuels. Technologies for energy storage and microgrids are also improving quickly and present additional ways to increase the wind and/or solar energy retained for later use with the network management flexibility to provide power to the appropriate locations when needed. As a result, renewable resources continue to gain more market share. The transitioning to renewables as the major resources for power will take some time as the conversion is complex and can have negative impacts if not managed well. While the economics for wind and solar systems continue to improve, the robustness of the WWR site was validated by the repeated queries of developers to place wind and/or solar there. The robust resources and improving technologies portends toward WWR land as a renewable energy site. The business case, however, is not so clear, especially when the potential investment portfolio for ACBCI has several very beneficial and profitable alternatives.« less

Academic Information System Support in the Era of Education 3.0

NASA Astrophysics Data System (ADS)

Utomo, HP; Bon, AT; Hendayun, M.

2017-08-01

The emergence of Education 3.0 as a new paradigm in education has been spread widely in many educational institutions, especially in higher education institutions (HEIs). Many of them have been implementing the new paradigm and get benefit from it. But somehow, the implementation caused some problems. The new policy and procedures are causing administrative problems, especially in the academic affair. The implementation also needs to provide external involvement. To overcome the problems, the academic information system (AIS) can be used to support the characteristics of Education 3.0. The purpose of the research is to find the possibility support from the AIS to the characteristics of Education 3.0. The research used Education 3.0 concept and information system (IS) concept to find the possibility. The research used a case study as the method and conducted a qualitative research with an unstructured interview. After comparing the Education 3.0 concept and IS concept with the interview analysis, the research found that all the characteristics of Education 3.0 can possibly support by the AIS. The result can be used as a guideline to develop the new AIS with the capability to support the characteristics of Education 3.0.

30 CFR 281.0 - Authority for information collection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Authority for information collection. 281.0 Section 281.0 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF General § 281.0 Authority...

30 CFR 282.0 - Authority for information collection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Authority for information collection. 282.0 Section 282.0 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OPERATIONS IN THE OUTER CONTINENTAL SHELF FOR MINERALS OTHER THAN OIL, GAS, AND SULPHUR General § 282.0...

TIM Version 3.0 beta - Technical Description and User's Guidance

EPA Pesticide Factsheets

Provides technical information on version 3.0 of the Terrestrial Investigation Model (TIM v.3.0). Describes how TIM derives joint distributions of exposure and toxicity to calculate the risk of mortality to birds.

Role of 3.0 Tesla magnetic resonance hysterosalpingography in the diagnostic work-up of female infertility.

PubMed

Cipolla, Valentina; Guerrieri, Daniele; Pietrangeli, Daniela; Santucci, Domiziana; Argirò, Renato; de Felice, Carlo

2016-09-01

Imaging evaluation plays a crucial role in the diagnostic work-up of female infertility. In recent years, the possibility to evaluate tubal patency using 1.5 Tesla magnetic resonance (1.5T MR) has been studied. To assess the feasibility of 3.0 Tesla magnetic resonance (3.0T MR) hysterosalpingography and its role in the diagnostic work-up of female infertility and to evaluate if this fast "one-stop-shop" imaging approach should be proposed as a first-line examination. A total of 116 infertile women were enrolled in this prospective study; all underwent 3.0T MR hysterosalpingography. After standard imaging of the pelvis, tubal patency was assessed by acquiring 3D dynamic time-resolved T1-weighted (T1W) sequences during manual injection of 4-5 mL of contrast solution consisting of gadolinium and normal sterile saline. Images were evaluated by two radiologists with different experience in MR imaging (MRI). The examination was successfully completed in 96.5% of cases, failure rate was 3.5%. Dynamic sequences showed bilateral tubal patency in 64.3%, unilateral tubal patency in 25.9%, and bilateral tubal occlusion in 9.8%. Extratubal abnormalities were found in 69.9% of patients. Comprehensive analysis of morphological and dynamic sequences showed extratubal abnormalities in 43.1% of patients with bilateral tubal patency. 3.0T MR hysterosalpingography is a feasible, simple, fast, safe, and well-tolerated examination, which allows evaluation of tubal patency and other pelvic causes of female infertility in a single session, and it may thus represent a "one-stop-shop" solution in female infertility diagnostic work-up. © The Foundation Acta Radiologica 2015.

Undercooling Behavior and Intermetallic Compound Coalescence in Microscale Sn-3.0Ag-0.5Cu Solder Balls and Sn-3.0Ag-0.5Cu/Cu Joints

NASA Astrophysics Data System (ADS)

Zhou, M. B.; Ma, X.; Zhang, X. P.

2012-11-01

The microstructure of microscale solder interconnects and soldering defects have long been known to have a significant influence on the reliability of electronic packaging, and both are directly related to the solidification behavior of the undercooled solder. In this study, the undercooling behavior and solidification microstructural evolution of Sn-3.0Ag-0.5Cu solder balls with different diameters (0.76 mm, 0.50 mm, and 0.30 mm) and the joints formed by soldering these balls on Cu open pads of two diameters (0.48 mm and 0.32 mm) on a printed circuit board (PCB) substrate were characterized by differential scanning calorimetry (DSC) incorporated into the reflow process. Results show that the decrease in diameter of the solder balls leads to an obvious increase in the undercooling of the balls, while the undercooling of the solder joints shows a dependence on both the diameter of the solder balls and the diameter ratio of solder ball to Cu pad (i.e., D s/ D p), and the diameter of the solder balls has a stronger influence on the undercooling of the joints than the dimension of the Cu pad. Coarse primary intermetallic compound (IMC) solidification phases were formed in the smaller solder balls and joints. The bulk Ag3Sn IMC is the primary solidification phase in the as-reflowed solder balls. Due to the interfacial reaction and dissolution of Cu atoms into the solder matrix, the primary Ag3Sn phase can be suppressed and the bulk Cu6Sn5 IMC is the only primary solidification phase in the as-reflowed solder joints.

Comparison of 7.0- and 3.0-T MRI and MRA in ischemic-type moyamoya disease: preliminary experience.

PubMed

Deng, Xiaofeng; Zhang, Zihao; Zhang, Yan; Zhang, Dong; Wang, Rong; Ye, Xun; Xu, Long; Wang, Bo; Wang, Kai; Zhao, Jizong

2016-06-01

OBJECT The authors compared the image quality and diagnostic sensitivity and specificity of 7.0-T and 3.0-T MRI and time-of-flight (TOF) MR angiography (MRA) in patients with moyamoya disease (MMD). METHODS MR images of 15 patients with ischemic-type MMD (8 males, 7 females; age 13-48 years) and 13 healthy controls (7 males, 6 females; age 19-28 years) who underwent both 7.0-T and 3.0-T MRI and MRA were studied retrospectively. The main intracranial arteries were assessed by using the modified Houkin's grading system (MRA score). Moyamoya vessels (MMVs) were evaluated by 2 grading systems: the MMV quality score and the MMV area score. Two diagnostic criteria for MMD were used: the T2 criteria, which used flow voids in the basal ganglion on T2-weighted images, and the TOF criteria, which used the high-intensity areas in the basal ganglion on source images from TOF MRA. All data were evaluated by 2 independent readers who were blinded to the strength field and presence or absence of MMD. Using conventional angiography as the gold standard, the sensitivity and specificity of 7.0-T and 3.0-T MRI/MRA in the diagnosis of MMD were calculated. The differences between 7.0-T and 3.0-T MRI and MRA were statistically compared. RESULTS No significant differences were observed between 7.0-T and 3.0-T MRA in MRA score (p = 0.317) or MRA grade (p = 0.317). There was a strong correlation between the Suzuki's stage and MRA grade in both 3.0-T (rs = 0.930; p < 0.001) and 7.0-T (rs = 0.966; p < 0.001) MRA. However, MMVs were visualized significantly better on 7.0-T than on 3.0-T MRA, suggested by both the MMV quality score (p = 0.001) and the MMV area score (p = 0.001). The correlation between the Suzuki's stage and the MMV area score was moderate in 3.0-T MRA (rs = 0.738; p = 0.002) and strong in 7.0-T MRA (rs = 0.908; p < 0.001). Moreover, 7.0-T MR images showed a greater capacity for detecting flow voids in the basal ganglion on both T2-weighted MR images (p < 0.001) and TOF source

45 CFR 30.3 - Antitrust, fraud, exception in the account of an accountable official, and interagency claims...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Antitrust, fraud, exception in the account of an accountable official, and interagency claims excluded. 30.3 Section 30.3 Public Welfare DEPARTMENT OF HEALTH... antitrust violations or fraud. (1) The standards in this part relating to compromise, suspension, and...

Ada Compiler Validation Summary Report: Certificate Number: 901129W1. 11096 Verdix Corporation, VADS Sequent Balance DYNIX 3.0, VAda-110-2323, Version 6.0, Sequent Balance 8000, DYNIX Version 3.0 (Host & Target).

DTIC Science & Technology

1991-08-01

90-09-25- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 901129W1.11096 Verdix Corporation VADS Sequent Balance DYNIX 3.0, VAda-1lO...8000, DYNIX Version 3.0 Target Computer System: Sequent Balance 8000, DYNIX Version 3.0 Customer Agreement Number: 90-09-25- VRX See Section 3.1 for any

Biobanking 3.0: evidence based and customer focused biobanking.

PubMed

Simeon-Dubach, Daniel; Watson, Peter

2014-03-01

Biobanking is a new and very dynamic field. To achieve long term financial sustainability of biobank infrastructures we propose that a new focus is needed on activities, products and services provided by the biobank that relate to the external stakeholder: biobanking 3.0. Earlier stages of biobanking are biobanking 1.0 (primary focus on the number of biospecimens and data) and biobanking 2.0 (primary focus on the quality of biospecimens and data). Both stages 1.0 and 2.0 are predominantly product oriented areas and have required a mostly internal focus on operational development within the biobank itself. In this paper we will introduce our concept of biobanking 3.0 which capitalizes on the earlier stages but dictates a shift in focus to enhancing the value and impact for the three major sets of external stakeholders (people/patients, funders, and research customers) and creating a path to balanced and planned investment in biobank infrastructure and the sustainability of biobanking. Biobanking 3.0 will improve real understanding as well as perceptions of value across different stakeholders. Patients and donors will appreciate seeing how their biospecimens and data are effectively used for research. Funders will value the ability to plan efficient targeting of funding and to monitor the impact of their support. Researchers will capitalize on the ability to translate their ideas into effective knowledge. Ultimately adoption of biobanking 3.0 will impact on the sustainability in the three main dimensions relevant to biobanking: social sustainability (acceptability), operational sustainability (efficiency), and financial sustainability (accomplishment). Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.

Geology, geochemistry, geochronology, and economic potential of Neogene volcanic rocks in the Laguna Pedernal and Salar de Aguas Calientes segments of the Archibarca lineament, northwest Argentina

NASA Astrophysics Data System (ADS)

Richards, J. P.; Jourdan, F.; Creaser, R. A.; Maldonado, G.; DuFrane, S. A.

2013-05-01

This study presents new geochemical, geochronological, isotopic, and mineralogical data, combined with new geological mapping for a 2400 km2 area of Neogene volcanic rocks in northwestern Argentina near the border with Chile, between 25°10‧S and 25°45‧S. The area covers the zone of intersection between the main axis of the Cordillera Occidental and a set of NW-SE-trending structures that form part of the transverse Archibarca lineament. This lineament has localized major ore deposits in Chile (e.g., the late Eocene La Escondida porphyry Cu deposit) and large volcanic centers such as the active Llullaillaco and Lastarría volcanoes on the border between Chile and Argentina, and the Neogene Archibarca, Antofalla, and Cerro Galán volcanoes in Argentina. Neogene volcanic rocks in the Laguna Pedernal and Salar de Aguas Calientes areas are mostly high-K calc-alkaline in composition, and range from basaltic andesites, through andesites and dacites, to rhyolites. Magmatic temperatures and oxidation states, estimated from mineral compositions, range from ~ 1000 °C and ∆FMQ ≈ 1.0-1.5 in andesites, to ~ 850 °C and ∆FMQ ≈ 1.5-2.0 in dacites and rhyolites. The oldest rocks consist of early-middle Miocene andesite-dacite plagioclase-pyroxene-phyric lava flows and ignimbrites, with 40Ar/39Ar ages ranging from 17.14 ± 0.10 Ma to 11.76 ± 0.27 Ma. Their major and trace element compositions are typical of the Andean Central Volcanic Zone, and show strong crustal contamination trends for highly incompatible elements such as Cs, Rb, Th, and U. These rocks are geochemically grouped as sub-suite 1. This widespread intermediate composition volcanism was followed in the middle-late Miocene by a period of more focused rhyodacitic flow-dome complex formation. These felsic rocks are characterized by less extreme enrichments in highly incompatible elements, and increasing depletion of heavy rare earth elements. These rocks are geochemically grouped as sub-suite 2. The

Breast Imaging: The Face of Imaging 3.0.

PubMed

Mayo, Ray Cody; Parikh, Jay R

2016-08-01

In preparation for impending changes to the health care delivery and reimbursement models, the ACR has provided a roadmap for success via the Imaging 3.0 (®)platform. The authors illustrate how the field of breast imaging demonstrates the following Imaging 3.0 concepts: value, patient-centered care, clinical integration, structured reporting, outcome metrics, and radiology's role in the accountable care organization environment. Much of breast imaging's success may be adapted and adopted by other fields in radiology to ensure that all radiologists become more visible and provide the value sought by patients and payers. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Specifications and Prototype of the Knowledge Repository (V.3.0) and the Knowledge Mediator (V.3.0)

ERIC Educational Resources Information Center

Andreou, Dimitris; Christophides, Vassilis; Flouris, Giorgos; Kotzinos, Dimitris; Pediaditis, Panagiotis; Tsialiamanis, Petros

2009-01-01

This deliverable reports the technical and research development performed until M36 (January 2009) within tasks T5.2 and T5.4 of WP5 in the KP-Lab project, per the latest Description of Work (DoW) 3.2 [DoW3.2]. The described components are included in the KP-Lab Semantic Web Knowledge Middleware (SWKM) Prototype Release 3.0 software that takes…

30 CFR 282.0 - Authority for information collection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Authority for information collection. 282.0 Section 282.0 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT... Service (MMS) of general mining operations in the Outer Continental Shalf (OCS). The information will be...

30 CFR 281.0 - Authority for information collection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Authority for information collection. 281.0 Section 281.0 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER...

The Minimum Data Set 3.0 Cognitive Function Scale.

PubMed

Thomas, Kali S; Dosa, David; Wysocki, Andrea; Mor, Vincent

2017-09-01

The Minimum Data Set (MDS) 3.0 introduced the Brief Interview for Mental Status (BIMS), a short performance-based cognitive screener for nursing home (NH) residents. Not all residents are able to complete the BIMS and are consequently assessed by staff. We designed a Cognitive Function Scale (CFS) integrating self-report and staff-report data and present evidence of the scale's construct validity. A retrospective cohort study. The subjects consisted of 3 cohorts: (1) long-stay NH residents (N=941,077) and (2) new admissions (N=2,066,580) during 2011-2012, and (3) residents with the older MDS 2.0 assessment in 2010 and the newer MDS 3.0 assessment (n=688,511). MDS 3.0 items were used to create a single, integrated 4-category hierarchical CFS that was compared with residents' prior MDS 2.0 Cognitive Performance Scale scores and other concurrent MDS 3.0 measures of construct validity. The new CFS suggests that 28% of the long-stay cohort in 2011-2012 were cognitively intact, 22% were mildly impaired, 33% were moderately impaired, and 17% were severely impaired. For the admission cohort, the CFS noted 56% as cognitively intact, 23% as mildly impaired, 17% as moderately impaired, and 4% as severely impaired. The CFS corresponded closely with residents' prior MDS 2.0 Cognitive Performance Scale scores and with performance of Activities of Daily Living, and nurses' judgments of function and behavior in both the admission and long-stay cohorts. The new CFS is valuable to researchers as it provides a single, integrated measure of NH residents' cognitive function, regardless of the mode of assessment.

Musculoskeletal MRI at 3.0 T and 7.0 T: a comparison of relaxation times and image contrast.

PubMed

Jordan, Caroline D; Saranathan, Manojkumar; Bangerter, Neal K; Hargreaves, Brian A; Gold, Garry E

2013-05-01

The purpose of this study was to measure and compare the relaxation times of musculoskeletal tissues at 3.0 T and 7.0 T, and to use these measurements to select appropriate parameters for musculoskeletal protocols at 7.0 T. We measured the T₁ and T₂ relaxation times of cartilage, muscle, synovial fluid, bone marrow and subcutaneous fat at both 3.0 T and 7.0 T in the knees of five healthy volunteers. The T₁ relaxation times were measured using a spin-echo inversion recovery sequence with six inversion times. The T₂ relaxation times were measured using a spin-echo sequence with seven echo times. The accuracy of both the T₁ and T₂ measurement techniques was verified in phantoms at both magnetic field strengths. We used the measured relaxation times to help design 7.0 T musculoskeletal protocols that preserve the favorable contrast characteristics of our 3.0 T protocols, while achieving significantly higher resolution at higher SNR efficiency. The T₁ relaxation times in all tissues at 7.0 T were consistently higher than those measured at 3.0 T, while the T₂ relaxation times at 7.0 T were consistently lower than those measured at 3.0 T. The measured relaxation times were used to help develop high resolution 7.0 T protocols that had similar fluid-to-cartilage contrast to that of the standard clinical 3.0 T protocols for the following sequences: proton-density-weighted fast spin-echo (FSE), T₂-weighted FSE, and 3D-FSE-Cube. The T₁ and T₂ changes were within the expected ranges. Parameters for musculoskeletal protocols at 7.0 T can be optimized based on these values, yielding improved resolution in musculoskeletal imaging with similar contrast to that of standard 3.0 T clinical protocols. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Benchmarking optimization software with COPS 3.0.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dolan, E. D.; More, J. J.; Munson, T. S.

2004-05-24

The authors describe version 3.0 of the COPS set of nonlinearly constrained optimization problems. They have added new problems, as well as streamlined and improved most of the problems. They also provide a comparison of the FILTER, KNITRO, LOQO, MINOS, and SNOPT solvers on these problems.

30 CFR 7.45 - Critical characteristics

Code of Federal Regulations, 2011 CFR

2011-07-01

... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Battery Assemblies § 7.45 Critical characteristics The following critical characteristics shall be inspected or tested on each battery assembly to...

30 CFR 7.45 - Critical characteristics

Code of Federal Regulations, 2012 CFR

2012-07-01

... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Battery Assemblies § 7.45 Critical characteristics The following critical characteristics shall be inspected or tested on each battery assembly to...

Intelligent Libraries and Apomediators: Distinguishing between Library 3.0 and Library 2.0

ERIC Educational Resources Information Center

Kwanya, Tom; Stilwell, Christine; Underwood, Peter G.

2013-01-01

Using the "point oh" naming system for developments in librarianship is attracting debate about its appropriateness, basis and syntax and the meaning and potential of Library 2.0. Now a new term, Library 3.0, has emerged. Is there is any significant difference between the two models? Using documentary analysis to explore the terms, the…

45 CFR 681.30 - Are ex parte communications between a party and the ALJ permitted?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Are ex parte communications between a party and... (Continued) NATIONAL SCIENCE FOUNDATION PROGRAM FRAUD CIVIL REMEDIES ACT REGULATIONS Hearing Procedures § 681.30 Are ex parte communications between a party and the ALJ permitted? Ex parte communications between...

Comparison of motor diagnoses by Chicago Classification versions 2.0 and 3.0 on esophageal high-resolution manometry.

PubMed

Patel, A; Cassell, B; Sainani, N; Wang, D; Shahid, B; Bennett, M; Mirza, F A; Munigala, S; Gyawali, C P

2017-07-01

The Chicago Classification (CC) uses high-resolution manometry (HRM) software tools to designate esophageal motor diagnoses. We evaluated changes in diagnostic designations between two CC versions, and determined motor patterns not identified by either version. In this observational cohort study of consecutive patients undergoing esophageal HRM over a 6-year period, proportions meeting CC 2.0 and 3.0 criteria were segregated into esophageal outflow obstruction, hypermotility, and hypomotility disorders. Contraction wave abnormalities (CWA), and 'normal' cohorts were recorded. Symptom burden was characterized using dominant symptom intensity and global symptom severity. Motor diagnoses, presenting symptoms, and symptom burden were compared between CC 2.0 and 3.0, and in cohorts not meeting CC diagnoses. Of 2569 eligible studies, 49.9% met CC 2.0 criteria, but only 40.3% met CC 3.0 criteria (P<.0001). Between CC 2.0 and 3.0, 82.8% of diagnoses were concordant. Discordance resulted from decreasing proportions of hypermotility (4.4%) and hypomotility (9.0%) disorders, and increase in 'normal' designations (13.0%); esophageal outflow obstruction showed the least variation between CC versions. Symptom burden was higher with CC 3.0 diagnoses (P≤.005) but not with CC 2.0 diagnoses (P≥.1). Within 'normal' cohorts for both CC versions, CWA were associated with higher likelihood of esophageal symptoms, especially dysphagia, regurgitation, and heartburn, compared to truly normal studies (P≤.02 for each comparison). Despite lower sensitivity, CC 3.0 identifies esophageal motor disorders with higher symptom burden compared to CC 2.0. CWA, which are associated with both transit and perceptive symptoms, are not well identified by either version. © 2017 John Wiley & Sons Ltd.

The Bologna Annotation Resource (BAR 3.0): improving protein functional annotation

PubMed Central

Casadio, Rita

2017-01-01

Abstract BAR 3.0 updates our server BAR (Bologna Annotation Resource) for predicting protein structural and functional features from sequence. We increase data volume, query capabilities and information conveyed to the user. The core of BAR 3.0 is a graph-based clustering procedure of UniProtKB sequences, following strict pairwise similarity criteria (sequence identity ≥40% with alignment coverage ≥90%). Each cluster contains the available annotation downloaded from UniProtKB, GO, PFAM and PDB. After statistical validation, GO terms and PFAM domains are cluster-specific and annotate new sequences entering the cluster after satisfying similarity constraints. BAR 3.0 includes 28 869 663 sequences in 1 361 773 clusters, of which 22.2% (22 241 661 sequences) and 47.4% (24 555 055 sequences) have at least one validated GO term and one PFAM domain, respectively. 1.4% of the clusters (36% of all sequences) include PDB structures and the cluster is associated to a hidden Markov model that allows building template-target alignment suitable for structural modeling. Some other 3 399 026 sequences are singletons. BAR 3.0 offers an improved search interface, allowing queries by UniProtKB-accession, Fasta sequence, GO-term, PFAM-domain, organism, PDB and ligand/s. When evaluated on the CAFA2 targets, BAR 3.0 largely outperforms our previous version and scores among state-of-the-art methods. BAR 3.0 is publicly available and accessible at http://bar.biocomp.unibo.it/bar3. PMID:28453653

Surface atomic structure of alloyed Mn 5Ge 3(0 0 0 1) by scanning tunneling microscopy

NASA Astrophysics Data System (ADS)

Kim, Howon; Jung, Goo-Eun; Yoon, Jong Keon; Chung, Kyung Hoon; Kahng, Se-Jong

Surface atomic structure of Mn 5Ge 3(0 0 0 1) is studied by scanning tunneling microscopy. Hexagonal honeycomb ordering is observed at high energy levels, ∣ E - EF∣ ˜ 1.2 eV, on the flat regions of three-dimensional Mn 5Ge 3 islands. At low energy levels, ∣ E - EF∣ ˜ 0.5 eV, however, atomic images exhibit dot-array and ring-array structures, which show complete and partial contrast inversion, compared to the honeycomb ordering. Experimental observations are discussed on the basis of possible atomic models.

Passage of Campylobacter jejuni and Campylobacter coli subtypes through 0.45 and 0.65 µm pore size nitro-cellulose filters

USDA-ARS?s Scientific Manuscript database

Campylobacter can be difficult to recover from complex samples due to overgrowth by background bacteria. A 0.45 or 0.65 µm pore size filter overlaid on agar plates can be used as a means to separate Campylobacter from confounding non-Campylobacter cells, facilitating detection on solid plating medi...

Translation and validation of Pediatric Quality of Life Inventory™ 3.0 Diabetes Module (PedsQL™ 3.0 Diabetes Module) in Brazil-Portuguese language.

PubMed

Garcia, Leila F Dos S; Manna, Thais Della; Passone, Caroline de Gouveia Buff; Oliveira, Lygia Spassapan de

2017-11-14

The aim of the present study was to create a translated version of the Pediatric Quality of Life Inventory™ 3.0 Diabetes Module (PedsQL™ 3.0 Diabetes Module) in Brazilian Portuguese that was conceptually equivalent to the original American English version and to linguistically validate it in a Brazilian pediatric population with type 1 diabetes mellitus and their parents or caregivers. The instrument was translated, back-translated, and then administered to 83 children/adolescents (5-18 years) with type 1 diabetes mellitus and their family members and to 25 parents/caregivers of patients aged between 2 and 4 years. The final translated version was tested for reliability by analyzing internal consistency, intraobserver (test-retest) reliability, and concurrent validity. Cronbach's alpha coefficient for the total score of the questionnaires of children/adolescents (α=0.85) and their parents (α=0.82) was above the recommended minimum of 0.70 for group comparisons. Intraobserver reliability and concurrent validity exhibited a significant positive correlation (p<0.001), indicating the reliability of the translated instrument. A moderate but significant positive correlation (r=0.40; p<0.001) was demonstrated between the total scores of patient self-report and parent proxy-report scales. There was no significant correlation between glycated hemoglobin (HbA1c) levels and the respective scores in the questionnaires answered by patients and their parents/caregivers. The analysis of the translated version of the PedsQL™ 3.0 Diabetes Module revealed adequate psychometric characteristics with respect to reliability and validity following administration to a sample of Brazilian children/adolescents with type 1 diabetes mellitus and their caregivers. Copyright © 2017. Published by Elsevier Editora Ltda.

30 CFR 18.45 - Cable reels.

Code of Federal Regulations, 2014 CFR

2014-07-01

... constitute an integral part of a circuit for transmitting electrical energy. (d) Cable reels for shuttle cars... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.45 Cable reels. (a) A self-propelled machine, that receives electrical energy through a portable...

30 CFR 18.45 - Cable reels.

Code of Federal Regulations, 2013 CFR

2013-07-01

... constitute an integral part of a circuit for transmitting electrical energy. (d) Cable reels for shuttle cars... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.45 Cable reels. (a) A self-propelled machine, that receives electrical energy through a portable...

30 CFR 18.45 - Cable reels.

Code of Federal Regulations, 2012 CFR

2012-07-01

... constitute an integral part of a circuit for transmitting electrical energy. (d) Cable reels for shuttle cars... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.45 Cable reels. (a) A self-propelled machine, that receives electrical energy through a portable...

30 CFR 18.45 - Cable reels.

Code of Federal Regulations, 2010 CFR

2010-07-01

... constitute an integral part of a circuit for transmitting electrical energy. (d) Cable reels for shuttle cars... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.45 Cable reels. (a) A self-propelled machine, that receives electrical energy through a portable...

30 CFR 18.45 - Cable reels.

Code of Federal Regulations, 2011 CFR

2011-07-01

... constitute an integral part of a circuit for transmitting electrical energy. (d) Cable reels for shuttle cars... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.45 Cable reels. (a) A self-propelled machine, that receives electrical energy through a portable...

30 CFR 7.45 - Critical characteristics

Code of Federal Regulations, 2014 CFR

2014-07-01

... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Battery Assemblies § 7.45 Critical characteristics The following critical characteristics shall be inspected or tested on each battery assembly to... terminations. (e) Strain relief devices for cables leaving boxes. (f) Type, location, and physical protection...

30 CFR 7.45 - Critical characteristics

Code of Federal Regulations, 2013 CFR

2013-07-01

... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Battery Assemblies § 7.45 Critical characteristics The following critical characteristics shall be inspected or tested on each battery assembly to... terminations. (e) Strain relief devices for cables leaving boxes. (f) Type, location, and physical protection...

30 CFR 7.45 - Critical characteristics

Code of Federal Regulations, 2010 CFR

2010-07-01

... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Battery Assemblies § 7.45 Critical characteristics The following critical characteristics shall be inspected or tested on each battery assembly to... terminations. (e) Strain relief devices for cables leaving boxes. (f) Type, location, and physical protection...

The Bologna Annotation Resource (BAR 3.0): improving protein functional annotation.

PubMed

Profiti, Giuseppe; Martelli, Pier Luigi; Casadio, Rita

2017-07-03

BAR 3.0 updates our server BAR (Bologna Annotation Resource) for predicting protein structural and functional features from sequence. We increase data volume, query capabilities and information conveyed to the user. The core of BAR 3.0 is a graph-based clustering procedure of UniProtKB sequences, following strict pairwise similarity criteria (sequence identity ≥40% with alignment coverage ≥90%). Each cluster contains the available annotation downloaded from UniProtKB, GO, PFAM and PDB. After statistical validation, GO terms and PFAM domains are cluster-specific and annotate new sequences entering the cluster after satisfying similarity constraints. BAR 3.0 includes 28 869 663 sequences in 1 361 773 clusters, of which 22.2% (22 241 661 sequences) and 47.4% (24 555 055 sequences) have at least one validated GO term and one PFAM domain, respectively. 1.4% of the clusters (36% of all sequences) include PDB structures and the cluster is associated to a hidden Markov model that allows building template-target alignment suitable for structural modeling. Some other 3 399 026 sequences are singletons. BAR 3.0 offers an improved search interface, allowing queries by UniProtKB-accession, Fasta sequence, GO-term, PFAM-domain, organism, PDB and ligand/s. When evaluated on the CAFA2 targets, BAR 3.0 largely outperforms our previous version and scores among state-of-the-art methods. BAR 3.0 is publicly available and accessible at http://bar.biocomp.unibo.it/bar3. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Stroke Impact Scale 3.0: Reliability and Validity Evaluation of the Korean Version.

PubMed

Choi, Seong Uk; Lee, Hye Sun; Shin, Joon Ho; Ho, Seung Hee; Koo, Mi Jung; Park, Kyoung Hae; Yoon, Jeong Ah; Kim, Dong Min; Oh, Jung Eun; Yu, Se Hwa; Kim, Dong A

2017-06-01

To establish the reliability and validity the Korean version of the Stroke Impact Scale (K-SIS) 3.0. A total of 70 post-stroke patients were enrolled. All subjects were evaluated for general characteristics, Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), Modified Barthel Index, Hospital Anxiety and Depression Scale (HADS). The SF-36 and K-SIS 3.0 assessed their health-related quality of life. Statistical analysis after evaluation, determined the reliability and validity of the K-SIS 3.0. A total of 70 patients (mean age, 54.97 years) participated in this study. Internal consistency of the SIS 3.0 (Cronbach's alpha) was obtained, and all domains had good co-efficiency, with threshold above 0.70. Test-retest reliability of SIS 3.0 required correlation (Spearman's rho) of the same domain scores obtained on the first and second assessments. Results were above 0.5, with the exception of social participation and mobility. Concurrent validity of K-SIS 3.0 was assessed using the SF-36, and other scales with the same or similar domains. Each domain of K-SIS 3.0 had a positive correlation with corresponding similar domain of SF-36 and other scales (HADS, MMSE, and NIHSS). The newly developed K-SIS 3.0 showed high inter-intra reliability and test-retest reliabilities, together with high concurrent validity with the original and various other scales, for patients with stroke. K-SIS 3.0 can therefore be used for stroke patients, to assess their health-related quality of life and treatment efficacy.

[Studies of three-dimensional cardiac late gadolinium enhancement MRI at 3.0 Tesla].

PubMed

Ishimoto, Takeshi; Ishihara, Masaru; Ikeda, Takayuki; Kawakami, Momoe

2008-12-20

Cardiac late Gadolinium enhancement MR imaging has been shown to allow assessment of myocardial viability in patients with ischemic heart disease. The current standard approach is a 3D inversion recovery sequence at 1.5 Tesla. The aims of this study were to evaluate the technique feasibility and clinical utility of MR viability imaging at 3.0 Tesla in patients with myocardial infarction and cardiomyopathy. In phantom and volunteer studies, the inversion time required to suppress the signal of interests and tissues was prolonged at 3.0 Tesla. In the clinical study, the average inversion time to suppress the signal of myocardium at 3.0 Tesla with respect to MR viability imaging at 1.5 Tesla was at 15 min after the administration of contrast agent (304.0+/-29.2 at 3.0 Tesla vs. 283.9+/-20.9 at 1.5 Tesla). The contrast between infarction and viable myocardium was equal at both field strengths (4.06+/-1.30 at 3.0 Tesla vs. 4.42+/-1.85 at 1.5 Tesla). Even at this early stage, MR viability imaging at 3.0 Tesla provides high quality images in patients with myocardial infarction. The inversion time is significantly prolonged at 3.0 Tesla. The contrast between infarction and viable myocardium at 3.0 Tesla are equal to 1.5 Tesla. Further investigation is needed for this technical improvement, for clinical evaluation, and for limitations.

Phakic Intraocular Lens Implantation: Refractive Outcome and Safety in Patients with Anterior Chamber Depth between 2.8 and 3.0 versus ≥3.0 mm.

PubMed

Guerra, Marta G; Silva, Andreia M M; Marques, Sara H M; Melo, Sofia H; Póvoa, João A; Lobo, Conceição; Murta, Joaquim Neto

2017-01-01

To compare endothelial cell (EC) variation after anterior chamber phakic intraocular lens (AC-pIOL) implantation in highly myopic patients with a preoperative anterior chamber depth (ACD) between 2.8 and 3.0 versus ≥3.0 mm. A total of 280 eyes submitted to primary AC-pIOL implantation were analyzed. Pre- and postoperative values for uncorrected distance visual acuity, corrected distance visual acuity, spherical equivalent, ACD (endothelial surface), and EC count were collected. The eyes were divided into 2 groups: group A - ACD between 2.8 and 3.0 mm; group B - ACD ≥3.0 mm. Mean global EC loss (ECL) and loss for each ACD group, according to pIOL type, were analyzed. Significant improvement of the spherical equivalent (-11.38 ± 4.57 vs. -0.49 ± 0.79; p = 0.000) and a significant decrease in EC density (2,810.95 ± 343.88 vs. 2,584.09 ± 374.88 cells/mm2; p = 0.000) were noted. The mean annual ECL was -2.19 ± 3.97%. Regarding group A (n = 80), a mean annual ECL of -2.06 ± 3.88% was registered, higher for the Acrysof Cachet® subtype, while group B (n = 200) showed -2.25 ± 4.01% ECL, higher for the Verisyse® subtype. There was no significant difference between the groups (p = 0.96). AC-pIOL implantation significantly improves the spherical equivalent in myopic patients. The mean annual ECL after pIOL implantation was higher in the larger ACD group, but this value was not statistically significant. A 2.8-mm ACD value seems to be a safe cutoff for AC-pIOL implantation. © 2017 S. Karger AG, Basel.

Stroke Impact Scale 3.0: Reliability and Validity Evaluation of the Korean Version

PubMed Central

2017-01-01

Objective To establish the reliability and validity the Korean version of the Stroke Impact Scale (K-SIS) 3.0. Methods A total of 70 post-stroke patients were enrolled. All subjects were evaluated for general characteristics, Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), Modified Barthel Index, Hospital Anxiety and Depression Scale (HADS). The SF-36 and K-SIS 3.0 assessed their health-related quality of life. Statistical analysis after evaluation, determined the reliability and validity of the K-SIS 3.0. Results A total of 70 patients (mean age, 54.97 years) participated in this study. Internal consistency of the SIS 3.0 (Cronbach's alpha) was obtained, and all domains had good co-efficiency, with threshold above 0.70. Test-retest reliability of SIS 3.0 required correlation (Spearman's rho) of the same domain scores obtained on the first and second assessments. Results were above 0.5, with the exception of social participation and mobility. Concurrent validity of K-SIS 3.0 was assessed using the SF-36, and other scales with the same or similar domains. Each domain of K-SIS 3.0 had a positive correlation with corresponding similar domain of SF-36 and other scales (HADS, MMSE, and NIHSS). Conclusion The newly developed K-SIS 3.0 showed high inter-intra reliability and test-retest reliabilities, together with high concurrent validity with the original and various other scales, for patients with stroke. K-SIS 3.0 can therefore be used for stroke patients, to assess their health-related quality of life and treatment efficacy. PMID:28758075

In-situ Raman spectroscopic investigation of LiMn1.45Ni0.45M0.1O4 (M = Cr, Co) 5 V cathode materials

NASA Astrophysics Data System (ADS)

Zhu, W.; Liu, D.; Trottier, J.; Gagnon, C.; Howe, J.; Mauger, A.; Julien, C. M.; Zaghib, K.

2015-12-01

In-situ Raman spectroscopy is employed to investigate the valence state variations of nickel and manganese, as well as the local structure change of LiMn1.45Ni0.45M0.1O4 (M = Cr, Co) cathodes (LMN) during galvanostatic charge-discharge. Raman spectra are collected between 3.5 and 4.9 V in the wave number range of 100-800 cm-1. The Raman observations showed that the pristine cathodes of Cr- and Co-doped LMN have essentially the same spectra, and they also have similar evolution patterns during cycling showing their reversible behaviour in the de-lithiation and lithiation processes. The Raman spectra of the pristine cathodes have eleven bands, located at 162, 220, 378, 408, 486, 498, 528, 593, 613, 639 and 672 cm-1. The bands with wave number <300 cm-1 are attributed to the translation mode of molecular vibration; the 486, 593 and 639 cm-1 bands are assigned to the stretching mode of Mn-O bond; and the vibration modes at 408, 498, 528 and 613 cm-1 originated from the Ni-O bond; The band at 672 cm-1 is attributed to A1g mode of Cr3+-O/Co3+-O. During cycling, several new bands are detected near the end of charge, among which the T2g(T) band at 170 cm-1 is attributed to the translation mode of lattice vibration in which the lithium concentration is low, and the T2g band at 538 cm-1 is due to the presence of Ni4+-O bond in the crystal structure. The T2g(T) and T2g(Ni4+-O) bands are clearly evident at V ≥ 4.78 (x ∼ 0.32) and V ≥ 4.82 (x ∼ 0.28) for Cr- and Co-doped LMN, respectively.

SEADS 3.0 Sectoral Energy/Employment Analysis and Data System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roop, Joseph M.; Anderson, David A.; Schultz, Robert W.

2007-12-17

SEADS 3.0, the Sectoral Energy/Employment Analysis and Data System, is a revision and upgrading of SEADS--PC, a software package designed for the analysis of policy that could be described by modifying final demands of consumer, businesses, or governments (Roop, et al., 1995). If a question can be formulated so that implications can be translated into changes in final demands for goods and services, then SEADS 3.0 provides a quick and easy tool to assess preliminary impacts. And SEADS 3.0 should be considered just that: a quick and easy way to get preliminary results. Often a thorough answer, even to suchmore » a simple question as, “What would be the effect on U. S. energy use and employment if the Federal Government doubled R&D expenditures?” requires a more sophisticated analytical framework than the input-output structure embedded in SEADS 3.0. This tool uses a static, input-output model to assess the impacts of changes in final demands on first industry output, then employment and energy use. The employment and energy impacts are derived by multiplying the industry outputs (derived from the changed final demands) by industry-specific energy and employment coefficients. The tool also allows for the specification of regional or state employment impacts, though this option is not available for energy impacts.« less

Assessment of radionuclide databases in CAP88 mainframe version 1.0 and Windows-based version 3.0.

PubMed

LaBone, Elizabeth D; Farfán, Eduardo B; Lee, Patricia L; Jannik, G Timothy; Donnelly, Elizabeth H; Foley, Trevor Q

2009-09-01

In this study the radionuclide databases for two versions of the Clean Air Act Assessment Package-1988 (CAP88) computer model were assessed in detail. CAP88 estimates radiation dose and the risk of health effects to human populations from radionuclide emissions to air. This program is used by several U.S. Department of Energy (DOE) facilities to comply with National Emission Standards for Hazardous Air Pollutants regulations. CAP88 Mainframe, referred to as version 1.0 on the U.S. Environmental Protection Agency Web site (http://www.epa.gov/radiation/assessment/CAP88/), was the very first CAP88 version released in 1988. Some DOE facilities including the Savannah River Site still employ this version (1.0) while others use the more user-friendly personal computer Windows-based version 3.0 released in December 2007. Version 1.0 uses the program RADRISK based on International Commission on Radiological Protection Publication 30 as its radionuclide database. Version 3.0 uses half-life, dose, and risk factor values based on Federal Guidance Report 13. Differences in these values could cause different results for the same input exposure data (same scenario), depending on which version of CAP88 is used. Consequently, the differences between the two versions are being assessed in detail at Savannah River National Laboratory. The version 1.0 and 3.0 database files contain 496 and 838 radionuclides, respectively, and though one would expect the newer version to include all the 496 radionuclides, 35 radionuclides are listed in version 1.0 that are not included in version 3.0. The majority of these has either extremely short or long half-lives or is no longer in production; however, some of the short-lived radionuclides might produce progeny of great interest at DOE sites. In addition, 122 radionuclides were found to have different half-lives in the two versions, with 21 over 3 percent different and 12 over 10 percent different.

ARL and Association 3.0: Ten Management Challenges

ERIC Educational Resources Information Center

Funk, Carla J.

2009-01-01

Association management in today's "association 3.0" environment presents some new challenges and new perspectives on old ones. This paper summarizes 10 such challenges including collaboration, diversity, innovation, transparency, financial stability, member benefits, knowledge-based decision-making, a demand-driven association model, pro-activity…

Categorical Regression and Benchmark Dose Software 3.0

EPA Science Inventory

The objective of this full-day course is to provide participants with interactive training on the use of the U.S. Environmental Protection Agency’s (EPA) Benchmark Dose software (BMDS, version 3.0, released fall 2018) and Categorical Regression software (CatReg, version 3.1...

Study of xCo0.8Ni0.2Fe2O4+(1-x) Pb0.99625 La0.0025Zr0.55Ti0.45O3 magnetoelectric composites

NASA Astrophysics Data System (ADS)

Dipti; Singh, Sangeeta; Juneja, J. K.; Raina, K. K.; Kotnala, R. K.; Prakash, Chandra

2016-06-01

We are reporting here, the studies of the structural, dielectric, ferroelectric and magnetic properties of magnetoelectric composites of La modified lead zirconate titanate (PLZT) and Ni modified cobalt ferrite (CNFO) with compositional formula xCo0.8Ni0.2Fe2O4+(1-x) Pb0.99625La0.0025Zr0.55Ti0.45O3 (x=0.00, 0.05, 0.10, 0.15 and 1.00 by weight) prepared by the solid state reaction method. Coexistence of both the phases in composites was confirmed by X-Ray diffraction technique. The microstructure and average grain size were determined from Scanning Electron Micrograph (SEM) in backscattered mode. Both the phases could be observed clearly. The variations of dielectric properties with frequency and temperature were also studied. P-E and M-H hysteresis measurements were carried. Magnetoelectric coupling (ME) coefficient for samples with x=0.05 and 0.10 were measured as a function of DC magnetic field. Maximum value of ME coefficient (1.2 mV/cm Oe) and piezoelectric coefficient (96 pC/N) for x=0.05 were observed.

Use of Myocardial T1 Mapping at 3.0 T to Differentiate Anderson-Fabry Disease from Hypertrophic Cardiomyopathy.

PubMed

Karur, Gauri R; Robison, Sean; Iwanochko, Robert M; Morel, Chantal F; Crean, Andrew M; Thavendiranathan, Paaladinesh; Nguyen, Elsie T; Mathur, Shobhit; Wasim, Syed; Hanneman, Kate

2018-04-24

Purpose To compare left ventricular (LV) and right ventricular (RV) 3.0-T cardiac magnetic resonance (MR) imaging T1 values in Anderson-Fabry disease (AFD) and hypertrophic cardiomyopathy (HCM) and evaluate the diagnostic value of native T1 values beyond age, sex, and conventional imaging features. Materials and Methods For this prospective study, 30 patients with gene-positive AFD (37% male; mean age ± standard deviation, 45.0 years ± 14.1) and 30 patients with HCM (57% male; mean age, 49.3 years ± 13.5) were prospectively recruited between June 2016 and September 2017 to undergo cardiac MR imaging T1 mapping with a modified Look-Locker inversion recovery (MOLLI) acquisition scheme at 3.0 T (repetition time msec/echo time msec, 280/1.12; section thickness, 8 mm). LV and RV T1 values were evaluated. Statistical analysis included independent samples t test, receiver operating characteristic curve analysis, multivariable logistic regression, and likelihood ratio test. Results Septal LV, global LV, and RV native T1 values were significantly lower in AFD compared with those in HCM (1161 msec ± 47 vs 1296 msec ± 55, respectively [P < .001]; 1192 msec ± 52 vs 1268 msec ± 55 [P < .001]; and 1221 msec ± 54 vs 1271 msec ± 37 [P = .001], respectively). A septal LV native T1 cutoff point of 1220 msec or lower distinguished AFD from HCM with sensitivity of 97%, specificity of 93%, and accuracy of 95%. Septal LV native T1 values differentiated AFD from HCM after adjustment for age, sex, and conventional imaging features (odds ratio, 0.94; 95% confidence interval: 0.91, 0.98; P = < .001). In a nested logistic regression model with age, sex, and conventional imaging features, model fit was significantly improved by the addition of septal LV native T1 values (χ 2 [df = 1] = 33.4; P < .001). Conclusion Cardiac MR imaging native T1 values at 3.0 T are significantly lower in patients with AFD compared with those with HCM and provide independent and incremental diagnostic

Development of a 0.014-in., anti-solenoid loop MR imaging guidewire for intravascular 3.0-T MR imaging.

PubMed

Gu, Huidong; Zhang, Feng; Meng, Yanfeng; Qiu, Bensheng; Yang, Xiaoming

2011-09-01

This study aimed to develop a 0.014-in., anti-solenoid loop (ASL) magnetic resonance imaging guidewire (MRIG) for intravascular 3.0-T MR imaging. We first designed the ASL MRIG, which was made of a coaxial cable with its extended inner conductor and outer conductor connected to two micro-anti-solenoids. We then evaluated in vitro the functionality of the ASL MRIG by imaging a "vessel" in a phantom and achieving signal-to-noise ratio (SNR) and SNR contour map of the new 0.014-in. ASL MRIG. Subsequently, we validated in vivo the feasibility of using the ASL MRIG to generate intravenous 3.0-T MR images of parallel iliofemoral arteries of near-human-sized living pigs. In vitro evaluation showed that the 0.014-in. ASL MRIG functioned well as a receiver coil with the 3.0-T MR scanner, clearly displaying the vessel wall with even distribution of MR signals and SNR contours from the ASL MRIG. Of the in vivo studies, the new ASL MRIG enabled us to successfully generate intravenous 3.0-T MR imaging of the iliofemoral arteries. This study confirms that it is possible to build such small-looped MRIG at 0.014 in. for intravascular 3.0-T MR imaging. Copyright © 2011 Elsevier Inc. All rights reserved.

Results of JAUS OPC Experiment 3.0

DTIC Science & Technology

2006-05-01

AFRL-ML-TY-TP-2006-4555 POSTPRINT RESULTS OF JAUS OPC EXPERIMENT 3.0 M.N. Clark Harris Corporation-GCSD Melbourne FL 32902-0037...permission to manufacture, use, or sell any patented invention that may relate to them. This technical report was reviewed and cleared for public...Service (NTIS). Reference PAO Case Number AFRL/MLQ-06-069. This report is releasable to the National Technical Information Service (NTIS) where

DRUGDOG 3.0: U.S. Navy Random Urinalysis Software Package

DTIC Science & Technology

1994-03-15

NAVAL PO11GRADUATE SCHOOL Monterey, California AD-A281 748 THESIS LJuEoTE DRUGDOG 3.0: U. S . NAVY RANDOM URINALYSIS SOFTWARE PACKAGE by (% Dale E...ONLY (Leave blank) 2. REPORT DATE 3. REPORT TYPE AND DATES COVERED 15 MAR 94 Master’s Thesis 4. TITLE AND SUBTITLE DRUGDOG 3.0: U. S . NAVY RANDOM 5...FUNDING NUMBERS URINALYSIS SOFTWARE PACKAGE 6. AUTHOR( S ) Dale E. Wilson 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING Naval

Relaxivity of Ferumoxytol at 1.5 T and 3.0 T.

PubMed

Knobloch, Gesine; Colgan, Timothy; Wiens, Curtis N; Wang, Xiaoke; Schubert, Tilman; Hernando, Diego; Sharma, Samir D; Reeder, Scott B

2018-05-01

The aim of this study was to determine the relaxation properties of ferumoxytol, an off-label alternative to gadolinium-based contrast agents, under physiological conditions at 1.5 T and 3.0 T. Ferumoxytol was diluted in gradually increasing concentrations (0.26-4.2 mM) in saline, human plasma, and human whole blood. Magnetic resonance relaxometry was performed at 37°C at 1.5 T and 3.0 T. Longitudinal and transverse relaxation rate constants (R1, R2, R2*) were measured as a function of ferumoxytol concentration, and relaxivities (r1, r2, r2*) were calculated. A linear dependence of R1, R2, and R2* on ferumoxytol concentration was found in saline and plasma with lower R1 values at 3.0 T and similar R2 and R2* values at 1.5 T and 3.0 T (1.5 T: r1saline = 19.9 ± 2.3 smM; r1plasma = 19.0 ± 1.7 smM; r2saline = 60.8 ± 3.8 smM; r2plasma = 64.9 ± 1.8 smM; r2*saline = 60.4 ± 4.7 smM; r2*plasma = 64.4 ± 2.5 smM; 3.0 T: r1saline = 10.0 ± 0.3 smM; r1plasma = 9.5 ± 0.2 smM; r2saline = 62.3 ± 3.7 smM; r2plasma = 65.2 ± 1.8 smM; r2*saline = 57.0 ± 4.7 smM; r2*plasma = 55.7 ± 4.4 smM). The dependence of relaxation rates on concentration in blood was nonlinear. Formulas from second-order polynomial fittings of the relaxation rates were calculated to characterize the relationship between R1blood and R2 blood with ferumoxytol. Ferumoxytol demonstrates strong longitudinal and transverse relaxivities. Awareness of the nonlinear relaxation behavior of ferumoxytol in blood is important for ferumoxytol-enhanced magnetic resonance imaging applications and for protocol optimization.

An Experiment with CC Version 3.0 Migration

DTIC Science & Technology

2006-09-01

7th International Common Criteria Conference Lanzarote , Spain September 19-21, 2006 An Experiment with CC Version 3.0 Migration Thuy D. Nguyen...SUPPLEMENTARY NOTES 7th International Common Criteria Conference (ICCC 06), Lanzarote , Spaon, 19-21 Sep 2006 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY

Transmittance of optical materials from 0.17 micro to 3.0 micro.

PubMed

McCarthy, D E

1967-11-01

The transmittance of thirty-one optical materials is given from 0.17, micro to 3.0 micro. Included are NaCl, KBr, CsBr, CsI, CaF(2), BaF(2), NaF, TlBr, TICL, KRS-5, KRS-6, T-12, KC, CuC, T O(2), ADP, KDP, SrTiO(3), GaP, CaCO(3), CdSe, As(2)S(3), ruby, Al(2)O(3), Irtran 1-6, and quartz. All are synthetic with the exception of CaCO(3). In many cases, the short wavelength cutoff of the synthetic materials is less than that which has been reported for naturally occurring materials.

AESOP 3.0 Highlights: Afloat Electromagnetic Spectrum Operations Program

DTIC Science & Technology

2011-03-01

Restricted Frequency List (JRFL) MCEB Pub 8, Version 2.0.1 (1 July 2010); Tactical Information - JRFL  Enhanced Mapping Capability 2-D and 3-D maps with...includes Joint Restricted Frequency List (JRFL) frequencies UNCLASSIFIED 14 Satellite Availability & Analysis (SA2) AESOP 3.0 – SA2 v5.7.2 Software

Challenging the 3.0 GPA Eligibility Standard for Public Relations Internships.

ERIC Educational Resources Information Center

Maynard, Michael L.

1999-01-01

Analyzes the appropriateness of a 3.0 GPA standard for public relations internship eligibility at one university. Seeks to determine at what GPA cutoff faculty can feel confident that the student will gain from the internship without damaging the program's reputation. Finds students with a 2.7 GPA did as well as students with GPAs ranging from 3.0…

The Global Ocean Forecast System, Version 3.0 (GOFS 3.0) or the Hybrid Coordinate Ocean Model (HYCOM)

DTIC Science & Technology

2012-04-10

System (GOFS) V3.0 – 1/12 HYCOM/NCODA: Phase I‖ by Metzger et al., dated 26 November 2008 (NRL/MR/7320—08- 9148). The HYbrid Coordinate Ocean...C. Lozano, H.L. Tolman, A. Srinivasan, S. Hankin, P. Cornillon, R. Weisberg, A. Barth, R. He, F. Werner, and J. Wilkin , 2009. U.S. GODAE: Global...E.J. Metzger, J.F. Shriver, O.M. Smedstad, A.J. Wallcraft, and C.N. Barron, 2008 : Eddy-resolving global ocean prediction. In "Eddy-Resolving Ocean

CARRIER-LATTICE RELAXATION FOR BROADENING EPR LINEWIDTH IN Nd0.55Sr0.45MnO3

NASA Astrophysics Data System (ADS)

Fan, Jiyu; Zhang, Xiyuan; Tong, Wei; Zhang, Lei; Zhang, Weichun; Zhu, Yan; Shi, Yangguang; Hu, Dazhi; Hong, Bo; Ying, Yao; Ling, Langsheng; Pi, Li; Zhang, Yuheng

2013-12-01

In this paper, we report the electron paramagnetic resonance (EPR) study of perovskite manganite Nd0.55Sr0.45MnO3. Experimental data reveal that the EPR linewidth broadens with a quasilinear manner up to 480 K. The broadening of the EPR linewidth can be understood in terms of the shortening of carrier-lattice relaxation time due to the occurrence of strong carrier-phonon interactions. Two same activation energies obtained respectively from the temperature dependence of EPR intensity and resistivity indicate that the linewidth variation is correlated to the small polaron hopping. Therefore, the carrier-lattice coupling play a major role for deciding its magnetism in the present system.

30 CFR 256.0 - Authority for information collection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management, General § 256.0 Authority for information collection. (a... information collection is “30 CFR part 256, Leasing of Sulphur or Oil and Gas in the Outer Continental Shelf...

Thermophilic methanogenesis in a hot-spring algal-bacterial mat (71 to 30/sup 0/C)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ward, D.M.

1978-06-01

Algal-bacterial mats which grow in the effluent channels of alkaline hot springs provided an environment suitable for studying natural thermophilic methane-producing bacteria. Methane was rapidly produced in cores taken from the mat and appeared to be an end product of decomposition of the algal-bacterial organic matter. Formaldehyde prevented production of methane. Initial methanogenic rate was lower and methanogenesis became exponential when samples were permitted to cool before laboratory incubation. Methanogenesis occurred and methanogenic bateria were present over a range of 68 to 30/sup 0/C, with optimum methanogenesis near 45/sup 0/C. The temperature distribution of methanogenesis in the mat is discussedmore » relative to published results on standing crop, primary production, and decomposition in the thermal gradient. The depth distribution of methanogenesis was similar to that of freshwater sediments, with a zone of intense methanogenesis near the mat surface. Methanogenesis in deeper mat layers was very low or undetectable despite large numbers of viable methanogenic bacteria and could not be stimulated by addition of anoxic source water, sulfide, or a macronutrient solution.« less

CASTp 3.0: computed atlas of surface topography of proteins.

PubMed

Tian, Wei; Chen, Chang; Lei, Xue; Zhao, Jieling; Liang, Jie

2018-06-01

Geometric and topological properties of protein structures, including surface pockets, interior cavities and cross channels, are of fundamental importance for proteins to carry out their functions. Computed Atlas of Surface Topography of proteins (CASTp) is a web server that provides online services for locating, delineating and measuring these geometric and topological properties of protein structures. It has been widely used since its inception in 2003. In this article, we present the latest version of the web server, CASTp 3.0. CASTp 3.0 continues to provide reliable and comprehensive identifications and quantifications of protein topography. In addition, it now provides: (i) imprints of the negative volumes of pockets, cavities and channels, (ii) topographic features of biological assemblies in the Protein Data Bank, (iii) improved visualization of protein structures and pockets, and (iv) more intuitive structural and annotated information, including information of secondary structure, functional sites, variant sites and other annotations of protein residues. The CASTp 3.0 web server is freely accessible at http://sts.bioe.uic.edu/castp/.

NPInter v3.0: an upgraded database of noncoding RNA-associated interactions

PubMed Central

Hao, Yajing; Wu, Wei; Li, Hui; Yuan, Jiao; Luo, Jianjun; Zhao, Yi; Chen, Runsheng

2016-01-01

Despite the fact that a large quantity of noncoding RNAs (ncRNAs) have been identified, their functions remain unclear. To enable researchers to have a better understanding of ncRNAs’ functions, we updated the NPInter database to version 3.0, which contains experimentally verified interactions between ncRNAs (excluding tRNAs and rRNAs), especially long noncoding RNAs (lncRNAs) and other biomolecules (proteins, mRNAs, miRNAs and genomic DNAs). In NPInter v3.0, interactions pertaining to ncRNAs are not only manually curated from scientific literature but also curated from high-throughput technologies. In addition, we also curated lncRNA–miRNA interactions from in silico predictions supported by AGO CLIP-seq data. When compared with NPInter v2.0, the interactions are more informative (with additional information on tissues or cell lines, binding sites, conservation, co-expression values and other features) and more organized (with divisions on data sets by data sources, tissues or cell lines, experiments and other criteria). NPInter v3.0 expands the data set to 491,416 interactions in 188 tissues (or cell lines) from 68 kinds of experimental technologies. NPInter v3.0 also improves the user interface and adds new web services, including a local UCSC Genome Browser to visualize binding sites. Additionally, NPInter v3.0 defined a high-confidence set of interactions and predicted the functions of lncRNAs in human and mouse based on the interactions curated in the database. NPInter v3.0 is available at http://www.bioinfo.org/NPInter/. Database URL: http://www.bioinfo.org/NPInter/ PMID:27087310

UPEML Version 3.0: A machine-portable CDC update emulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mehlhorn, T.A.; Haill, T.A.

1992-04-01

UPEML is a machine-portable program that emulates a subset of the functions of the standard CDC Update. Machine-portability has been achieved by conforming to ANSI standards for Fortran-77. UPEML is compact and fairly efficient; however, it only allows a restricted syntax as compared with the CDC Update. This program was written primarily to facilitate the use of CDC-based scientific packages on alternate computer systems such as the VAX/VMS mainframes and UNIX workstations. UPEML has also been successfully used on the multiprocessor ELXSI, on CRAYs under both UNICOS and CTSS operating systems, and on Sun, HP, Stardent and IBM workstations. UPEMLmore » was originally released with the ITS electron/photon Monte Carlo transport package, which was developed on a CDC-7600 and makes extensive use of conditional file structure to combine several problem geometry and machine options into a single program file. UPEML 3.0 is an enhanced version of the original code and is being independently released for use at any installation or with any code package. Version 3.0 includes enhanced error checking, full ASCII character support, a program library audit capability, and a partial update option in which only selected or modified decks are written to the complete file. Version 3.0 also checks for overlapping corrections, allows processing of pested calls to common decks, and allows the use of alternate files in READ and ADDFILE commands. Finally, UPEML Version 3.0 allows the assignment of input and output files at runtime on the control line.« less

CPHmodels-3.0--remote homology modeling using structure-guided sequence profiles.

PubMed

Nielsen, Morten; Lundegaard, Claus; Lund, Ole; Petersen, Thomas Nordahl

2010-07-01

CPHmodels-3.0 is a web server predicting protein 3D structure by use of single template homology modeling. The server employs a hybrid of the scoring functions of CPHmodels-2.0 and a novel remote homology-modeling algorithm. A query sequence is first attempted modeled using the fast CPHmodels-2.0 profile-profile scoring function suitable for close homology modeling. The new computational costly remote homology-modeling algorithm is only engaged provided that no suitable PDB template is identified in the initial search. CPHmodels-3.0 was benchmarked in the CASP8 competition and produced models for 94% of the targets (117 out of 128), 74% were predicted as high reliability models (87 out of 117). These achieved an average RMSD of 4.6 A when superimposed to the 3D structure. The remaining 26% low reliably models (30 out of 117) could superimpose to the true 3D structure with an average RMSD of 9.3 A. These performance values place the CPHmodels-3.0 method in the group of high performing 3D prediction tools. Beside its accuracy, one of the important features of the method is its speed. For most queries, the response time of the server is <20 min. The web server is available at http://www.cbs.dtu.dk/services/CPHmodels/.

Influence of buffer-layer construction and substrate orientation on the electron mobilities in metamorphic In{sup 0.70}Al{sup 0.30}As/In{sup 0.76}Ga{sup 0.24}As/In{sup 0.70}Al{sup 0.30}As structures on GaAs substrates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kulbachinskii, V. A., E-mail: kulb@mig.phys.msu.ru; Oveshnikov, L. N.; Lunin, R. A.

The influence of construction of the buffer layer and misorientation of the substrate on the electrical properties of In{sup 0.70}Al{sup 0.30}As/In{sup 0.76}Ga{sup 0.24}As/In{sup 0.70}Al{sup 0.30}As quantum wells on a GaAs substrate is studied. The temperature dependences (in the temperature range of 4.2 K < T < 300 K) and field dependences (in magnetic fields as high as 6 T) of the sample resistances are measured. Anisotropy of the resistances in different crystallographic directions is detected; this anisotropy depends on the substrate orientation and construction of the metamorphic buffer layer. In addition, the Hall effect and the Shubnikov–de Haas effect aremore » studied. The Shubnikov–de Haas effect is used to determine the mobilities of electrons separately in several occupied dimensionally quantized subbands in different crystallographic directions. The calculated anisotropy of mobilities is in agreement with experimental data on the anisotropy of the resistances.« less

Clustering for the Development of Engineering Students' Use of Enterprise 3.0

ERIC Educational Resources Information Center

Bassus, Olaf; Ahrens, Andreas; Zascerinska, Jelena

2011-01-01

Enterprise 3.0 which penetrates our society more thoroughly with the availability of broadband services has already been widely integrated into the contemporary processes and work environments. The synergy between Enterprise 3.0 and clustering advances innovation-stimulating environments in engineering education. The present research proposes…

Web 1.0 to Web 3.0 Evolution: Reviewing the Impacts on Tourism Development and Opportunities

NASA Astrophysics Data System (ADS)

Eftekhari, M. Hossein; Barzegar, Zeynab; Isaai, M. T.

The most important event following the establishmenet of the Internet network was the Web introduced by Tim Berners-Lee. Websites give their owners features that allow sharing with which they can publish their content with users and visitors. In the last 5 years, we have seen some changes in the use of web. Users want to participate in content sharing and they like to interact with each other. This is known as Web 2.0. In the last year, Web 2.0 has reached maturity and now we need a smart web which will be accordingly be called Web 3.0. Web 3.0 is based on semantic web definition. Changing the way of using the web has had a clear impact on E-Tourism and its development and also on business models. In this paper, we review the definitions and describe the impacts of web evolution on E-Tourism.

Study of conduction behavior in Pr0.67Sr0.03Ag0.30MnO3

NASA Astrophysics Data System (ADS)

Bhat, Masroor Ahmad; Modi, Anchit; Pandey, Devendra K.; Gaur, N. K.

2018-05-01

In this paper, we report the conduction mechanism in Pr0.67Sr0.03Ag0.30MnO3 system synthesized via conventional solid state reaction route. The structural information was carried by X - Ray diffraction using Rietveld refinement which confirms the secondary phase of the sample. The SEM image shows the formation of double phase composite because of limited reaction of silver with parent compound. The resistivity behavior indicates the semiconducting behavior. The electronic nature can be estimated by means of variable range hopping (VRH) and small polaron hopping (SPH) model showing that the enhancement of double exchange interaction suppress the band gap and boost the carrier delocalization of charge carriers.

[Chemical Exchange Saturation Transfer Imaging of Creatine Metabolites: a 3.0 T MRI Pilot].

PubMed

Guo, Ying-kun; Li, Zhen-lin; Rong, Yu; Xia, Chun-chao; Zhang, Li-zhi; Peng, Wan-ling; Liu, Xi; Xu, Hua-yan; Zhang, Ti-jiang; Zuo, Pan-li; Schmitt, Benjamin

2016-03-01

To determine the feasibility of using chemical exchange saturation transfer (CEST) imaging to measure creatine (Cr) metabolites with 3.0 T MR. Phantoms containing different concentrations of Cr under various pH conditions were studied with CEST sequence on 3.0 T MR imaging. CEST effect and Z spectra were analyzed. Cr exhibited significant CEST effect (± 1.8 ppm, F = 99.08, P < 0.001) on 3.0 T MR imaging, and positive correlation was found between the signal intensity and concentration of Cr (r = 0.963, P < 0.001). The CEST effect showed pH dependency of Cr (r = 0.41, P = 0.035). Creatine CEST imaging can be performed on 3.0 T MR imaging. Creatine concentrations and pH influence CEST effect.

The solid solution K3.84Ni0.78Fe3.19(PO4)5

PubMed Central

Strutynska, Nataliia Yu.; Ogorodnyk, Ivan V.; Livitska, Oksana V.; Baumer, Vyacheslav N.; Slobodyanik, Nikolay S.

2014-01-01

The title compound, tetra­potassium tetra­[nickel(II)/iron(III)] penta­kis­(orthophosphate), K3.84Ni0.78Fe3.19(PO4)5, has been obtained from a flux. The structure is isotypic with that of K4MgFe3(PO4)5. The three-dimensional framework is built up from (Ni/Fe)O5 trigonal bipyramids with a mixed Fe:Ni occupancy of 0.799 (8):0.196 (10) and isolated PO4 tetra­hedra, one of which is on a general position and one of which has -4.. site symmetry. Two K+ cations are statistically occupied and are distributed over two positions in hexa­gonally shaped channels that run parallel to [001]. One K+ cation [occupancy 0.73 (3)] is surrounded by nine O atoms, while the other K+ cation [occupancy 0.23 (3)] is surrounded by eight O atoms. PMID:25161510

Concept development of a Mach 3.0 high-speed civil transport

NASA Technical Reports Server (NTRS)

Robins, A. Warner; Dollyhigh, Samuel M.; Beissner, Fred L., Jr.; Geiselhart, Karl; Martin, Glenn L.; Shields, E. W.; Swanson, E. E.; Coen, Peter G.; Morris, Shelby J., Jr.

1988-01-01

A baseline concept for a Mach 3.0 high-speed civil transport concept was developed as part of a national program with the goal that concepts and technologies be developed which will enable an effective long-range high-speed civil transport system. The Mach 3.0 concept reported represents an aggressive application of advanced technology to achieve the design goals. The level of technology is generally considered to be that which could have a demonstrated availability date of 1995 to 2000. The results indicate that aircraft are technically feasible that could carry 250 passengers at Mach 3.0 cruise for a 6500 nautical mile range at a size, weight and performance level that allows it to fit into the existing world airport structure. The details of the configuration development, aerodynamic design, propulsion system design and integration, mass properties, mission performance, and sizing are presented.

High Temperature Operation of Al 0.45Ga 0.55N/Al 0.30Ga 0.70 N High Electron Mobility Transistors

DOE PAGES

Baca, Albert G.; Armstrong, Andrew M.; Allerman, Andrew A.; ...

2017-08-01

AlGaN-channel high electron mobility transistors (HEMTs) are among a class of ultra wide-bandgap transistors that have a bandgap greater than ~3.4 eV, beyond that of GaN and SiC, and are promising candidates for RF and power applications. Long-channel Al xGa 1-xN HEMTs with x = 0.3 in the channel have been built and evaluated across the -50°C to +200°C temperature range. Room temperature drain current of 70 mA/mm, absent of gate leakage, and with a modest -1.3 V threshold voltage was measured. A very large I on/I off current ratio, greater than 10 8 was demonstrated over the entire temperaturemore » range, indicating that off-state leakage is below the measurement limit even at 200°C. Finally, combined with near ideal subthreshold slope factor that is just 1.3× higher than the theoretical limit across the temperature range, the excellent leakage properties are an attractive characteristic for high temperature operation.« less

High Temperature Operation of Al 0.45Ga 0.55N/Al 0.30Ga 0.70 N High Electron Mobility Transistors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baca, Albert G.; Armstrong, Andrew M.; Allerman, Andrew A.

AlGaN-channel high electron mobility transistors (HEMTs) are among a class of ultra wide-bandgap transistors that have a bandgap greater than ~3.4 eV, beyond that of GaN and SiC, and are promising candidates for RF and power applications. Long-channel Al xGa 1-xN HEMTs with x = 0.3 in the channel have been built and evaluated across the -50°C to +200°C temperature range. Room temperature drain current of 70 mA/mm, absent of gate leakage, and with a modest -1.3 V threshold voltage was measured. A very large I on/I off current ratio, greater than 10 8 was demonstrated over the entire temperaturemore » range, indicating that off-state leakage is below the measurement limit even at 200°C. Finally, combined with near ideal subthreshold slope factor that is just 1.3× higher than the theoretical limit across the temperature range, the excellent leakage properties are an attractive characteristic for high temperature operation.« less

Exposure-response analyses of liraglutide 3.0 mg for weight management.

PubMed

Wilding, J P H; Overgaard, R V; Jacobsen, L V; Jensen, C B; le Roux, C W

2016-05-01

Liraglutide 3.0 mg, an acylated GLP-1 analogue approved for weight management, lowers body weight through decreased energy intake. We conducted exposure-response analyses to provide important information on individual responses to given drug doses, reflecting inter-individual variations in drug metabolism, absorption and excretion. We report efficacy and safety responses across a wide range of exposure levels, using data from one phase II (liraglutide doses 1.2, 1.8, 2.4 and 3.0 mg), and two phase IIIa [SCALE Obesity and Prediabetes (3.0 mg); SCALE Diabetes (1.8; 3.0 mg)] randomized, placebo-controlled trials (n = 4372). There was a clear exposure-weight loss response. Weight loss increased with greater exposure and appeared to level off at the highest exposures associated with liraglutide 3.0 mg in most individuals, but did not fully plateau in men. In individuals with overweight/obesity and comorbid type 2 diabetes, there was a clear exposure-glycated haemoglobin (HbA1c) relationship. HbA1c reduction increased with higher plasma liraglutide concentration (plateauing at ∼21 nM); however, for individuals with baseline HbA1c >8.5%, HbA1c reduction did not fully plateau. No exposure-response relationship was identified for any safety outcome, with the exception of gastrointestinal adverse events (AEs). Individuals with gallbladder AEs, acute pancreatitis or malignant/breast/benign colorectal neoplasms did not have higher liraglutide exposure compared with the overall population. These analyses support the use of liraglutide 3.0 mg for weight management in all subgroups investigated; weight loss increased with higher drug exposure, with no concomitant deterioration in safety/tolerability besides previously known gastrointestinal side effects. © 2016 John Wiley & Sons Ltd.

Liraglutide 3.0 mg for Weight Management: A Population Pharmacokinetic Analysis.

PubMed

Overgaard, Rune V; Petri, Kristin C; Jacobsen, Lisbeth V; Jensen, Christine B

2016-11-01

This analysis used a population pharmacokinetic approach to identify covariates that influence plasma exposure of liraglutide 3.0 mg, a glucagon-like peptide-1 (GLP-1) receptor agonist approved for weight management in overweight and obese individuals. Samples for pharmacokinetic analysis were drawn at weeks 2, 12 and 28 of the phase IIIa SCALE Obesity and Prediabetes (N = 2339) and SCALE Diabetes (N = 584) trials. Dose proportionality of liraglutide in obese subjects was investigated using data from a phase II dose-finding study (N = 331). Dose-proportional exposure of liraglutide up to and including 3.0 mg was confirmed. Body weight and sex influenced exposure of liraglutide 3.0 mg, while age ≥70 years, race, ethnicity and baseline glycaemic status did not. Compared with a reference subject weighing 100 kg, exposure of liraglutide 3.0 mg was 44 % lower for a subject weighing 234 kg (90 % CI 41-47), 41 % higher for a subject weighing 60 kg (90 % CI 37-46), and 32 % higher (90 % CI 28-35) in females than males with the same body weight. Neither injection site nor renal function significantly influenced exposure of liraglutide 3.0 mg (post hoc analysis). Population pharmacokinetics of liraglutide up to and including 3.0 mg daily in overweight and obese adults demonstrated dose-proportional exposure, and limited effect of covariates other than sex and body weight. These findings were similar to those previously observed with liraglutide up to 1.8 mg in subjects with type 2 diabetes mellitus. Further analysis of exposure-response relationship and its effect on dose requirements is addressed in a separate publication.

Exposure–response analyses of liraglutide 3.0 mg for weight management

PubMed Central

Overgaard, R. V.; Jacobsen, L. V.; Jensen, C. B.; le Roux, C. W.

2016-01-01

Aims Liraglutide 3.0 mg, an acylated GLP‐1 analogue approved for weight management, lowers body weight through decreased energy intake. We conducted exposure‐response analyses to provide important information on individual responses to given drug doses, reflecting inter‐individual variations in drug metabolism, absorption and excretion. Methods We report efficacy and safety responses across a wide range of exposure levels, using data from one phase II (liraglutide doses 1.2, 1.8, 2.4 and 3.0 mg), and two phase IIIa [SCALE Obesity and Prediabetes (3.0 mg); SCALE Diabetes (1.8; 3.0 mg)] randomized, placebo‐controlled trials (n = 4372). Results There was a clear exposure–weight loss response. Weight loss increased with greater exposure and appeared to level off at the highest exposures associated with liraglutide 3.0 mg in most individuals, but did not fully plateau in men. In individuals with overweight/obesity and comorbid type 2 diabetes, there was a clear exposure–glycated haemoglobin (HbA1c) relationship. HbA1c reduction increased with higher plasma liraglutide concentration (plateauing at ∼21 nM); however, for individuals with baseline HbA1c >8.5%, HbA1c reduction did not fully plateau. No exposure–response relationship was identified for any safety outcome, with the exception of gastrointestinal adverse events (AEs). Individuals with gallbladder AEs, acute pancreatitis or malignant/breast/benign colorectal neoplasms did not have higher liraglutide exposure compared with the overall population. Conclusions These analyses support the use of liraglutide 3.0 mg for weight management in all subgroups investigated; weight loss increased with higher drug exposure, with no concomitant deterioration in safety/tolerability besides previously known gastrointestinal side effects. PMID:26833744

Development and Validation of the Pediatric Medical Complexity Algorithm (PMCA) Version 3.0.

PubMed

Simon, Tamara D; Haaland, Wren; Hawley, Katherine; Lambka, Karen; Mangione-Smith, Rita

2018-02-26

To modify the Pediatric Medical Complexity Algorithm (PMCA) to include both International Classification of Diseases, Ninth and Tenth Revisions, Clinical Modification (ICD-9/10-CM) codes for classifying children with chronic disease (CD) by level of medical complexity and to assess the sensitivity and specificity of the new PMCA version 3.0 for correctly identifying level of medical complexity. To create version 3.0, PMCA version 2.0 was modified to include ICD-10-CM codes. We applied PMCA version 3.0 to Seattle Children's Hospital data for children with ≥1 emergency department (ED), day surgery, and/or inpatient encounter from January 1, 2016, to June 30, 2017. Starting with the encounter date, up to 3 years of retrospective discharge data were used to classify children as having complex chronic disease (C-CD), noncomplex chronic disease (NC-CD), and no CD. We then selected a random sample of 300 children (100 per CD group). Blinded medical record review was conducted to ascertain the levels of medical complexity for these 300 children. The sensitivity and specificity of PMCA version 3.0 was assessed. PMCA version 3.0 identified children with C-CD with 86% sensitivity and 86% specificity, children with NC-CD with 65% sensitivity and 84% specificity, and children without CD with 77% sensitivity and 93% specificity. PMCA version 3.0 is an updated publicly available algorithm that identifies children with C-CD, who have accessed tertiary hospital emergency department, day surgery, or inpatient care, with very good sensitivity and specificity when applied to hospital discharge data and with performance to earlier versions of PMCA. Copyright © 2018 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

30 CFR 203.0 - What definitions apply to this part?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What definitions apply to this part? 203.0 Section 203.0 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT... of construction) means evidence of an irreversible commitment to a concept and scale of development...

Results of irradiation of (U0.55Pu0.45)N and (U0.4Pu0.6)N fuels in BOR-60 up to ˜12 at.% burn-up

NASA Astrophysics Data System (ADS)

Rogozkin, B. D.; Stepennova, N. M.; Fedorov, Yu. Ye.; Shishkov, M. G.; Kryukov, F. N.; Kuzmin, S. V.; Nikitin, O. N.; Belyaeva, A. V.; Zabudko, L. M.

2013-09-01

In the article presented are the results of post-irradiation tests of helium bonded fuel pins with mixed mononitride fuel (U0.55Pu0.45)N and (U0.4Pu0.6)N having 85% density irradiated in BOR-60 reactor. Achieved maximum burn-up was, respectively, equal to 9.4 and 12.1 at.% with max linear heat rates 41.9 and 54.5 kW/m. Maximum irradiation dose was 43 dpa. No damage of claddings made of ChS-68 steel (20% cold worked) was observed, and ductility margin existed. Maximum depth of cladding corrosion was within 15 μm. Swelling rates of (U0.4Pu0.6)N and (U0.55Pu0.45)N were, respectively, ˜1.1% and ˜0.68% per 1 at.%. Gas release rate did not exceed 19.3% and 19%. Pattern of porosity distribution in the fuel influenced fuel swelling and gas release rates. Plutonium and uranium are uniformly distributed in the fuel, local minimum values of their content being caused by pores and cracks in the pellets. The observable peaks in content distribution are probably connected with the local formation of isolated phases (e.g. Mo, Pd) while the minimum values refer to fuel pores and cracks. Xenon and cesium tend to migrate from the hot sections of fuel, and therefore their min content is observed in the central section of the fuel pellets. Phase composition of the fuel was determined with X-ray diffractometer. The X-ray patterns of metallographic specimens were obtained by the scanning method (the step was 0.02°, the step exposition was equal to 2 s). From the X-ray diffraction analysis data, it follows that the nitrides of both fuel types have the single-phase structure with an FCC lattice (see Table 6).

Effects of Sm3+ on Luminescent Properties of LiEu(0.55-x)Y0.45 (WO4)2Smx Red Phosphor

NASA Astrophysics Data System (ADS)

Zailani, N. S.; Ghazli, M. F.; Hussin, R.; Rahim, S. Z. Abd; Mat Saad, M. N.

2018-06-01

Phosphor materials have been widely applied in lighting and displays. Rare earth elements are amongst important elements in giving luminescent properties to the phosphor. The needs to reduce rare earth element in phosphor is of interest due to cost and environmental issue. The red phosphor LiEu(0.55-x)Y0.45(WO4)2 were synthesized by substituting Sm3+ in the lattice using solid-state reaction. The effect on the substitution of Sm3+ which acts as an activator will be analysed using X-ray powder diffraction (XRPD), scanning electron microscope (SEM) and photoluminescence spectra (PL). The structure of the compound was found to be as a monoclinic which referred to the reference patterns. The optimum amount was recorded for the activator to be obtained in the host lattice for replacing the Eu3+ place as well as enhancing the intensity of the emission. The findings reveal that LiEu(0.55-x)Y0.45(MoO4)2Smx can be a more efficient red phosphor candidate used white light emitting diodes (WLEDs) applications.

ECONOMIC GROWTH ANALYSIS SYSTEM: USER'S GUIDE - VERSION 3.0

EPA Science Inventory

The two-volume report describes the development of, and provides information needed to operate, the Economic Growth Analysis System (E-GAS) Version 3.0 model. The model will be used to project emissions inventories of volatile organic compounds, oxides of nitrogen, and carbon mon...

ECONOMIC GROWTH ANALYSIS SYSTEM: REFERENCE MANUAL VERSION 3.0

EPA Science Inventory

The two-volume report describes the development of, and provides information needed to operate, the Economic Growth Analysis System (E-GAS) Version 3.0 model. The model will be used to project emissions inventories of volatile organic compounds, oxides of nitrogen, and carbon mon...

Mineralogic Model (MM3.0) Analysis Model Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

C. Lum

2002-02-12

The purpose of this report is to document the Mineralogic Model (MM), Version 3.0 (MM3.0) with regard to data input, modeling methods, assumptions, uncertainties, limitations and validation of the model results, qualification status of the model, and the differences between Version 3.0 and previous versions. A three-dimensional (3-D) Mineralogic Model was developed for Yucca Mountain to support the analyses of hydrologic properties, radionuclide transport, mineral health hazards, repository performance, and repository design. Version 3.0 of the MM was developed from mineralogic data obtained from borehole samples. It consists of matrix mineral abundances as a function of x (easting), y (northing),more » and z (elevation), referenced to the stratigraphic framework defined in Version 3.1 of the Geologic Framework Model (GFM). The MM was developed specifically for incorporation into the 3-D Integrated Site Model (ISM). The MM enables project personnel to obtain calculated mineral abundances at any position, within any region, or within any stratigraphic unit in the model area. The significance of the MM for key aspects of site characterization and performance assessment is explained in the following subsections. This work was conducted in accordance with the Development Plan for the MM (CRWMS M&O 2000). The planning document for this Rev. 00, ICN 02 of this AMR is Technical Work Plan, TWP-NBS-GS-000003, Technical Work Plan for the Integrated Site Model, Process Model Report, Revision 01 (CRWMS M&O 2000). The purpose of this ICN is to record changes in the classification of input status by the resolution of the use of TBV software and data in this report. Constraints and limitations of the MM are discussed in the appropriate sections that follow. The MM is one component of the ISM, which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components

[Effect of 45 degree angle semirecumbent position on ventilator-associated pneumonia in mechanical ventilated patients: a meta-analysis].

PubMed

Leng, Yu-xin; Song, Ya-han; Yao, Zhi-yuan; Zhu, Xi

2012-10-01

To systemically analyze the effect of 45 degree angle semirecumbent position on the incidence of ventilator-associated pneumonia (VAP) and other outcomes in mechanical ventilated patients, and to evaluate whether 45 degree angle semirecumbent position is superior to 25 degree angle-30 degree angle head of bed (HOB). The randomized controlled trials (RCTs) comparing the effect of different HOB on the outcomes of mechanical ventilated patients were searched (from 1st January 1990 to 20th July 2012) from five databases including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, China Knowledge Resource Integrated Database (CNKI), and Wanfang Database. Meta analysis was conducted using RevMan 5.0 software. Data extracted from five RCTs with a total of 427 patients were analyzed. The risks of developing clinically diagnosed VAP were significantly lower among the patients in semirecumbent 45 degree angle position compared to the patients in lower position [15.96% (34/213) vs. 26.64% (57/214), relative risk (RR)=0.57, 95% confidence interval (95%CI) 0.39 to 0.83, P=0.003], while no significant differences were detected between the two groups regarding the mortality rate [27.04% (53/196) vs. 28.22% (57/202), RR=0.93, 95%CI 0.68 to 1.27, P=0.66], the length of intensive care unit (ICU) stay [weighted mean difference (WMD)=-0.45, 95%CI -1.08 to 0.18, P=0.16] and the percentage of antibiotics treatment [71.11% (32/45) vs. 60.87% (28/46), RR=1.14, 95%CI 0.85 to 1.53, P=0.37]. Two of the five trials (91 patients) were included in the sub-analysis between 45 degree angle group (45 patients) and 25 degree angle-30 degree angle group (46 patients). The results showed that comparing with 25 degree angle-30 degree angle, 45 degree angle semirecumbent position had no significance in improving patients' clinical outcomes. This study proved that the clinically preferred semirecumbent 45 degree angle position did have effect in reducing the incidence of VAP

SRTM Perspective View with Landsat Overlay: Caliente Range and Cuyama Valley, California

NASA Technical Reports Server (NTRS)

2001-01-01

Before the arrival of Europeans, California's Cuyama Valley was inhabited by Native Americans who were culturally and politically tied to the Chumash tribes of coastal Santa Barbara County. Centuries later, the area remains the site of noted Native American rock art paintings. In the 1800s, when Europeans established large cattle and horse-breeding ranches in the valley, the early settlers reported the presence of small villages along the Cuyama River. This perspective view looks upstream toward the southeast through the Cuyama Valley. The Caliente Range, with maximum elevations of 1,550 meters (5,085 feet), borders the valley on the left. The Cuyama River, seen as a bright meandering line on the valley floor, enters the valley from headwaters more than 2,438 meters (8,000 feet) above sea level near Mount Abel and flows 154 kilometers (96 miles) before emptying into the Pacific Ocean. The river's course has been determined in large part by displacement along numerous faults.

Today, the Cuyama Valley is the home of large ranches and small farms. The area has a population of 1,120 and is more than an hour and a half drive from the nearest city in the county.

This image was generated by draping an enhanced Landsat satellite image over elevation data from the Shuttle Radar Topography Mission (SRTM). Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter resolution of most Landsat images and will substantially help in analyses of the large and growing Landsat image archive. For visualization purposes, topographic heights displayed in this image are exaggerated two times. Colors approximate natural colors.

The elevation data used in this image was acquired by SRTM aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on Endeavour in 1994. SRTM

45 CFR 1357.30 - B).

Code of Federal Regulations, 2010 CFR

1996-10-01

... (title IV PUBLIC WELFARE Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT... TO TITLE IV-B Sec. 1357.30 Fiscal requirements (title IV-B). (a) The requirements of this section shall apply to all funds allotted or reallotted to States under title IV-B and to all funds not needed...

Molecular signatures database (MSigDB) 3.0.

PubMed

Liberzon, Arthur; Subramanian, Aravind; Pinchback, Reid; Thorvaldsdóttir, Helga; Tamayo, Pablo; Mesirov, Jill P

2011-06-15

Well-annotated gene sets representing the universe of the biological processes are critical for meaningful and insightful interpretation of large-scale genomic data. The Molecular Signatures Database (MSigDB) is one of the most widely used repositories of such sets. We report the availability of a new version of the database, MSigDB 3.0, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site. MSigDB is freely available for non-commercial use at http://www.broadinstitute.org/msigdb.

Geology of the platanares geothermal area, Departamento de Copan, Honduras

USGS Publications Warehouse

Heiken, G.; Ramos, N.; Duffield, W.; Musgrave, J.; Wohletz, K.; Priest, S.; Aldrich, J.; Flores, W.; Ritchie, A.; Goff, F.; Eppler, D.; Escobar, C.

1991-01-01

Platanares is located 16 km west of Santa Rosa de Copan, Honduras, along the Quebrada del Agua Caliente. The thermal manifestations are along faults in tuffs, tuffaceous sedimentary rocks, and lavas of the Padre Miguel Group. These tuffs are silicified near the faults, are fractured, and may provide the fracture permeability necessary for the hydrothermal system. Tuffs are overlain by a wedge of terrace gravels up to 60 m thick. Quaternary conglomerates of the Quebrada del Agua Caliente are cemented by silica sinter. The Platanares area contains numerous faults, all of which appear to be extensional. There are four groups of faults (N80/sup 0/E to N70/sup 0/W, N30/sup 0/ to 60/sup 0/W, N40/sup 0/ to 65/sup 0/E, and N00/sup 0/ to 05/sup 0/W). All hot springs at this site are located along faults that trend mostly northwest and north. Twenty-eight spring groups were described over an area of 0.2 km/sup 2/; half were boiling. Based on surface temperatures and flow rates, between 0.7 and 1.0 MW thermal energy is estimated for the area. The increased temperature of the stream flowing through the thermal area indicates that several megawatts of thermal energy are being added to the stream. We recommend that a dipole-dipole resistivity line be run along the Quebrada del Agua Caliente to identify zones of fracture permeability associated with buried faults and hot water reservoirs within those fault zones. A thermal gradient corehole should be drilled at Platanares to test temperatures, lithologies, and permeability of the hydrothermal system.

Composite (La0.45Nd0.25)Sr0.3MnO3/5CuO materials for magnetic refrigeration applications

NASA Astrophysics Data System (ADS)

El Maalam, K.; Balli, M.; Habouti, S.; Dietze, M.; Hamedoun, M.; Hlil, E.-K.; Es-Souni, M.; El Kenz, A.; Benyoussef, A.; Mounkachi, O.

2018-03-01

In this work, the magnetocaloric properties of (La0.45Nd0.25)Sr0.3MnO3 (LNSMO)-based composites are studied. The structural, microstructural, magnetic and magnetocaloric properties of LNSMO and LNSMO/5CuO samples were investigated aiming to particularly clarify the secondary phase (CuO) role in driving the magnetocaloric behavior. The main phase LNSMO crystallizes in a rhombohedral R-3C (1 6 7) configuration. The XRD patterns of composite samples show both perovskite LNSMO and monoclinic Tenorite CuO structures. The microstructural analysis unveils that the CuO phase is mainly present in the grain boundaries and segregates region. On the other hand, it was found that the magnetocaloric effect could be significantly enhanced by adding a small amount of CuO (5% weight ratio). For a magnetic field changing from 0 to 1.5 T, the corresponding isothermal entropy change was found to be 2.55 J/kg K for the LNSMO/5CuO composite while it is only about 1.1 J/kg K for the mother material LNSMO. Our finding should inspire and open new ways for the enhancement of the magnetocaloric effect in manganites-based materials.

Inclusion Needs of 3.0 Students in Latin America

ERIC Educational Resources Information Center

Budden, Connie B.; Brenes, Lizette; Baraya, Aristides R.; Budden, Michael C.

2010-01-01

Recent changes in information and communication technologies offer people unprecedented opportunities to generate and share knowledge. Currently, inclusion refers to equal opportunities for the 3.0 person and it is not limited to special physical needs or reducing the digital divide. Faced with this reality, universities, in general must transform…

Radiologist manpower considerations and Imaging 3.0: effort planning for value-based imaging.

PubMed

Norbash, Alexander; Bluth, Edward; Lee, Christoph I; Francavilla, Michael; Donner, Michael; Dutton, Sharon C; Heilbrun, Marta; McGinty, Geraldine

2014-10-01

Our specialty is seeking to establish the value of imaging in the longitudinal patient-care continuum. We recognize the need to assess the value of our contributions rather than concentrating primarily on generating revenue. This recent focus is a result of both increased cost-containment efforts and regulatory demands. Imaging 3.0 is a value-based perspective that intends to describe and facilitate value-based imaging. Imaging 3.0 includes a broad set of initiatives addressing the visibility of radiologists, and emphasizing quality and safety oversight by radiologists, which are new directions of focus for us. Imaging 3.0 also addresses subspecialty imaging and off-hours imaging, which are existing areas of practice that are emblematic of inconsistent service delivery across all hours. Looking to the future, Imaging 3.0 describes how imaging services could be integrated into the framework of accountable care organizations. Although all these efforts may be essential, they necessitate manpower expenditures, and these efforts are not directly covered by revenue. If we recognize the urgency of need in developing these concepts, we can justify the manpower and staffing expenditures each organization is willing to shoulder in reaching Imaging 3.0. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Frequency-dependent impedance spectroscopy on the 0.925(Bi0.5Na0.40K0.10)TiO3-0.075(Ba0.70Sr0.30)TiO3 ceramic

NASA Astrophysics Data System (ADS)

Ullah, Amir; Rahman, Muneeb-ur; Iqbal, Muhammad Javid; Ahn, Chang Won; Kim, Ill Won; Ullah, Aman

2016-06-01

The electrical properties of the 0.925(Bi0.5(Na0.40K0.10)TiO3-0.075(Ba0.70Sr0.30)TiO3 (0.925BNKT-0.075BST) ceramic were investigated by using AC impedance spectroscopy over a wide range of frequencies (10 -2 ~ 105 Hz). The X-ray diffraction patterns confirmed the formation of a single-phase compound. A single semicircular arc in the impedance spectrum indicates that the main contribution of the bulk resistance ( R b ) were due to grain effects, with Rb decreasing with increasing temperature. The conductivity of the ceramics increased with increasing temperature, and the activation energy resulting from the DC conductivity was 0.86 eV. The ceramic displayed a typical negative temperature coefficient of resistance (NTCR) behavior, like that of a semiconductor.

DOE/NV/26383-LTR2008-01 Letter Report Yucca Mountain Environmental Monitoring Systems Initiative - Air Quality Scoping Study for Caliente, Lincoln County, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. Engelbrecht; I. Kavouras; D. Campbell

2009-04-02

The Desert Research Institute (DRI) is performing a scoping study as part of the U.S. Department of Energy's Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at eight sites outside the NTS, including Ash Meadows National Wildlife Refuge (NWR), Beatty, Sarcobatus Flats, Rachel, Caliente, Pahranagat NWR, Crater Flat, and Tonopah Airport, and at four sites on the NTS (Engelbrecht et al., 2007a-d).more » The trailer is stationed at any one site for approximately eight weeks at a time. This letter report provides a summary of air quality and meteorological data, on completion of the site's sampling program.« less

GCAM 3.0 Agriculture and Land Use: Data Sources and Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kyle, G. Page; Luckow, Patrick; Calvin, Katherine V.

This report presents the data processing methods used in the GCAM 3.0 agriculture and land use component, starting from all source data used, and detailing all calculations and assumptions made in generating the model inputs. The report starts with a brief introduction to modeling of agriculture and land use in GCAM 3.0, and then provides documentation of the data and methods used for generating the base-year dataset and future scenario parameters assumed in the model input files. Specifically, the report addresses primary commodity production, secondary (animal) commodity production, disposition of commodities, land allocation, land carbon contents, and land values.

45 CFR 1355.30 - Other applicable regulations.

Code of Federal Regulations, 2013 CFR

2013-10-01

....30 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES GENERAL § 1355.30...

Simbrain 3.0: A flexible, visually-oriented neural network simulator.

PubMed

Tosi, Zachary; Yoshimi, Jeffrey

2016-11-01

Simbrain 3.0 is a software package for neural network design and analysis, which emphasizes flexibility (arbitrarily complex networks can be built using a suite of basic components) and a visually rich, intuitive interface. These features support both students and professionals. Students can study all of the major classes of neural networks in a familiar graphical setting, and can easily modify simulations, experimenting with networks and immediately seeing the results of their interventions. With the 3.0 release, Simbrain supports models on the order of thousands of neurons and a million synapses. This allows the same features that support education to support research professionals, who can now use the tool to quickly design, run, and analyze the behavior of large, highly customizable simulations. Copyright © 2016 Elsevier Ltd. All rights reserved.

ORDEM 3.0 and the Risk of High-Density Debris

NASA Technical Reports Server (NTRS)

Matney, Mark; Anz-Meador, Philip

2014-01-01

NASA’s Orbital Debris Engineering Model was designed to calculate orbital debris fluxes on spacecraft in order to assess collision risk. The newest of these models, ORDEM 3.0, has a number of features not present in previous models. One of the most important is that the populations and fluxes are now broken out into material density groups. Previous models concentrated on debris size alone, but a particle’s mass and density also determine the amount of damage it can cause. ORDEM 3.0 includes a high-density component, primarily consisting of iron/steel particles that drive much of the risk to spacecraft. This paper will outline the methods that were used to separate and identify the different densities of debris, and how these new densities affect the overall debris flux and risk.

Total Ionizing Dose Effects on Ge Channel $p$FETs with Raised $${\\rm Si}_{0.55}{\\rm Ge}_{0.45}$$ Source/Drain

DOE PAGES

Wang, Liang; Zhang, En Xia; Schrimpf, Ronald D.; ...

2015-12-17

Here, the total ionizing dose response of Ge channel pFETs with raised Si 0.55Ge 0.45 source/drain is investigated under different radiation bias conditions. Threshold-voltage shifts and transconductance degradation are noticeable only for negative-bias (on state) irradiation, and are mainly due to negative bias-temperature instability (NBTI). Nonmonotonic leakage changes during irradiation are observed, which are attributed to the competition of radiation-induced field transistor leakage and S/D junction leakage.

Field comparison of tolerance of a collar containing 10.0% imidacloprid/4.5% flumethrin (Seresto) and a placebo collar placed on cats.

PubMed

Fink, Heidi; Wennogle, Sara; Davis, Wendell L; Von Simson, Cristiano; Lappin, Michael R

2016-12-01

A collar containing 10.0% imidacloprid/4.5% flumethrin (Seresto; Bayer Animal Health) controls flea and tick infestations for 8 months and is effective in preventing transmission of Bartonella henselae and Cytauxzoon felis among cats. The purpose of this study was to compare tolerance of client-owned cats for the 10.0% imidacloprid/4.5% flumethrin collar or a physically identical placebo collar. A total of 96 client-owned cats were enrolled in the study. Cats that were systemically ill, of hairless breed or declawed in all four limbs were excluded. Cats were randomized by household to wear a placebo collar for 14 days followed by the 10.0% imidacloprid/4.5% flumethrin collar for 14 days or the 10.0% imidacloprid/4.5% flumethrin collar for 28 days. Examinations by a veterinarian were performed on days 0, 14 and 28. Owners recorded daily systemic and local health observations. All but two cats, including one that entrapped the mandible in the collar and one that developed local pyodermatitis (10.0% imidacloprid/4.5% flumethrin collar), completed the 28 day study. The majority of the local lesions or licking associated with the collars occurred in the first 14 days, and licking (but not skin lesions) was more common in cats wearing the 10.0% imidacloprid/4.5% flumethrin collars. No local lesions were reported for placebo cats after switching to the 10.0% imidacloprid/4.5% flumethrin collar, and only one cat wearing the 10.0% imidacloprid/4.5% flumethrin collar had reports of licking after day 14. Housing status, single or multiple cat household, and whether a collar had been worn previously were not associated with side effects. Adverse events detected for cats wearing 10.0% imidacloprid/4.5% flumethrin collars were similar to those for cats wearing placebo collars and to cats wearing identification collars in a separate study. The data suggest that most cats originally intolerant of collars become receptive over time. © The Author(s) 2015.

The new OGC Catalogue Services 3.0 specification - status of work

NASA Astrophysics Data System (ADS)

Bigagli, Lorenzo; Voges, Uwe

2013-04-01

We report on the work of the Open Geospatial Consortium Catalogue Services 3.0 Standards Working Group (OGC Cat 3.0 SWG for short), started in March 2008, with the purpose to process change requests on the Catalogue Services 2.0.2 Implementation Specification (OGC 07-006r1) and produce a revised version thereof, comprising the related XML schemas and abstract test suite. The work was initially intended as a minor revision (version 2.1), but later retargeted as a major update of the standard and rescheduled (the anticipated roadmap ended in 2008). The target audience of Catalogue Services 3.0 includes: • Implementors of catalogue services solutions. • Designers and developers of catalogue services profiles. • Providers/users of catalogue services. The two main general areas of enhancement included: restructuring the specification document according to the OGC standard for modular specifications (OGC 08-131r3, also known as Core and Extension model); incorporating the current mass-market technologies for discovery on the Web, namely OpenSearch. The document was initially split into four parts: the general model and the three protocol bindings HTTP, Z39.50, and CORBA. The CORBA binding, which was very rarely implemented, and the Z39.50 binding have later been dropped. Parts of the Z39.50 binding, namely Search/Retrieve via URL (SRU; same semantics as Z39.50, but stateless), have been provided as a discussion paper (OGC 12-082) for possibly developing a future SRU profile. The Catalogue Services 3.0 specification is structured as follows: • Part 1: General Model (Core) • Part 2: HTTP Protocol Binding (CSW) In CSW, the GET/KVP encoding is mandatory. The POST/XML encoding is optional. SOAP is supported as a special case of the POST/XML encoding. OpenSearch must always be supported, regardless of the implemented profiles, along with the OpenSearch Geospatial and Temporal Extensions (OGC 10-032r2). The latter specifies spatial (e.g. point-plus-radius, bounding

Fuel Characteristic Classification System version 3.0: technical documentation

Treesearch

Susan J. Prichard; David V. Sandberg; Roger D. Ottmar; Ellen Eberhardt; Anne Andreu; Paige Eagle; Kjell Swedin

2013-01-01

The Fuel Characteristic Classification System (FCCS) is a software module that records wildland fuel characteristics and calculates potential fire behavior and hazard potentials based on input environmental variables. The FCCS 3.0 is housed within the Integrated Fuels Treatment Decision Support System (Joint Fire Science Program 2012). It can also be run from command...

Orbital superconductivity, defects, and pinned nematic fluctuations in the doped iron chalcogenide FeSe 0.45 Te 0.55

DOE PAGES

Sarkar, Saheli; Van Dyke, John; Sprau, Peter O.; ...

2017-08-09

We demonstrate that the differential conductance, dI/dV , measured via spectroscopic imaging scanning tunneling microscopy in the doped iron chalcogenide FeSe0.45Te0.55, possesses a series of characteristic features that allow one to extract the orbital structure of the superconducting gaps. This yields nearly isotropic superconducting gaps on the two hole-like Fermi surfaces, and a strongly anisotropic gap on the electron-like Fermi surface. Moreover, we show that the pinning of nematic fluctuations by defects can give rise to a dumbbell-like spatial structure of the induced impurity bound states, and explains the related C 2-symmetry in the Fourier transformed differential conductance.

Orbital superconductivity, defects, and pinned nematic fluctuations in the doped iron chalcogenide FeSe 0.45 Te 0.55

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarkar, Saheli; Van Dyke, John; Sprau, Peter O.

We demonstrate that the differential conductance, dI/dV , measured via spectroscopic imaging scanning tunneling microscopy in the doped iron chalcogenide FeSe0.45Te0.55, possesses a series of characteristic features that allow one to extract the orbital structure of the superconducting gaps. This yields nearly isotropic superconducting gaps on the two hole-like Fermi surfaces, and a strongly anisotropic gap on the electron-like Fermi surface. Moreover, we show that the pinning of nematic fluctuations by defects can give rise to a dumbbell-like spatial structure of the induced impurity bound states, and explains the related C 2-symmetry in the Fourier transformed differential conductance.

Orbital superconductivity, defects, and pinned nematic fluctuations in the doped iron chalcogenide FeSe 0.45 Te 0.55

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarkar, Saheli; Van Dyke, John; Sprau, Peter O.

We demonstrate that the differential conductance, dI/dV, measured via spectroscopic imaging scanning tunneling microscopy in the doped iron chalcogenide FeSe0.45Te0.55, possesses a series of characteristic features that allow one to extract the orbital structure of the superconducting gaps. This yields nearly isotropic superconducting gaps on the two holelike Fermi surfaces, and a strongly anisotropic gap on the electronlike Fermi surface. Moreover, we show that the pinning of nematic fluctuations by defects can give rise to a dumbbell-like spatial structure of the induced impurity bound states, and explains the related C-2 symmetry in the Fourier transformed differential conductance.

Performance observations based on a subset of the DICOM 3.0 draft standard

NASA Astrophysics Data System (ADS)

Moore, Stephen M.; Blaine, G. James; Jost, R. Gilbert

1993-09-01

The American College of Radiology (ACR) and the National Electrical Manufacturers Association (NEMA) are defining the Digital Imaging and Communications in Medicine (DICOM) V3.0 Standard. Previous authors have investigated the performance of the ACR- NEMA V1.0 and V2.0 Standards in point to point and network applications. This paper describes an early implementation of a subset of the DICOM V3.0 Standard and presents performance results for a combination of workstation types and network technologies.

O*NET[TM] Career Exploration Tools. Version 3.0.

ERIC Educational Resources Information Center

Employment and Training Administration (DOL), Washington, DC.

Developed by the U.S. Department of Labor's Occupational Information Network (O*NET) team, the O*NET[TM] Career Exploration Tools (Version 3.0) consist of three main parts: (1) the Interest Profiler; (2) the Work Importance Locator; and (3) the O*NET[TM] Occupations Combined List. The Interest Profiler is a self-assessment career exploration tool…

30 CFR 203.45 - If I drill a certified unsuccessful well, what royalty relief will my lease earn?

Code of Federal Regulations, 2011 CFR

2011-07-01

... REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Deep Gas Wells on Leases Not Subject to Deep Water Royalty Relief § 203.45 If I drill a certified unsuccessful well, what... 30 Mineral Resources 2 2011-07-01 2011-07-01 false If I drill a certified unsuccessful well, what...

Defect reduction in Si-doped Al{sub 0.45}Ga{sub 0.55}N films by SiN{sub x} interlayer method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yang; Chen, Shengchang; Kong, Man

2014-01-28

The dislocation density in AlGaN epitaxial layers with Al content as high as 45% grown on sapphire substrates has been effectively reduced by introducing an in-situ deposited SiN{sub x} nanomask layer in this study. By closely monitoring the evolution of numerous material properties, such as surface morphology, dislocation density, photoluminescence, strain states, and electron mobility of the Si-Al{sub 0.45}Ga{sub 0.55}N layers as the functions of SiN{sub x} interlayer growth time, the surface coverage fraction of SiN{sub x} is found to be a crucial factor determining the strain states and dislocation density. The dependence of the strain states and the dislocationmore » density on the surface coverage fraction of SiN{sub x} nanomask supports the very different growth models of Al-rich AlGaN on SiN{sub x} interlayer due to the reduced nucleation selectivity compared with the GaN counterpart. Compared with GaN, which can only nucleate at open pores of SiN{sub x} nanomask, Al-rich AlGaN can simultaneously nucleate at both open pores and SiN{sub x} covered areas. Dislocations will annihilate at the openings due to the 3D growth initiated on the opening area, while 2D growth mode is preserved on SiN{sub x} and the threading dislocations are also preserved. During the following growth process, lateral overgrowth will proceed from the Al{sub 0.45}Ga{sub 0.55}N islands on the openings towards the regions covered by SiN{sub x}, relaxing the compressive strain and bending the dislocations at the same time.« less

Solar Effects of Low-Earth Orbit objects in ORDEM 3.0

NASA Technical Reports Server (NTRS)

Vavrin, A. B.; Anz-Meador, P.; Kelley, R. L.

2014-01-01

Variances in atmospheric density are directly related to the variances in solar flux intensity between 11- year solar cycles. The Orbital Debris Engineering Model (ORDEM 3.0) uses a solar flux table as input for calculating orbital lifetime of intact and debris objects in Low-Earth Orbit. Long term projections in solar flux activity developed by the NASA Orbital Debris Program Office (ODPO) extend the National Oceanic and Atmospheric Administration Space Environment Center (NOAA/SEC) daily historical flux values with a 5-year projection. For purposes of programmatic scheduling, the Q2 2009 solar flux table was chosen for ORDEM 3.0. Current solar flux activity shows that the current solar cycle has entered a period of lower solar flux intensity than previously forecasted in 2009. This results in a deviation of the true orbital debris environment propagation in ORDEM 3.0. In this paper, we present updated orbital debris populations in LEO using the latest solar flux values. We discuss the effects on recent breakup events such as the FY-1C anti-satellite test and the Iridium 33 / Cosmos 2251 accidental collision. Justifications for chosen solar flux tables are discussed.

[Optimization of diagnosis indicator selection and inspection plan by 3.0T MRI in breast cancer].

PubMed

Jiang, Zhongbiao; Wang, Yunhua; He, Zhong; Zhang, Lejun; Zheng, Kai

2013-08-01

To optimize 3.0T MRI diagnosis indicator in breast cancer and to select the best MRI scan program. Totally 45 patients with breast cancers were collected, and another 35 patients with benign breast tumor served as the control group. All patients underwent 3.0T MRI, including T1- weighted imaging (T1WI), fat suppression of the T2-weighted imaging (T2WI), diffusion weighted imaging (DWI), 1H magnetic resonance spectroscopy (1H-MRS) and dynamic contrast enhanced (DCE) sequence. With operation pathology results as the gold standard in the diagnosis of breast diseases, the pathological results of benign and malignant served as dependent variables, and the diagnostic indicators of MRI were taken as independent variables. We put all the indicators of MRI examination under Logistic regression analysis, established the Logistic model, and optimized the diagnosis indicators of MRI examination to further improve MRI scan of breast cancer. By Logistic regression analysis, some indicators were selected in the equation, including the edge feature of the tumor, the time-signal intensity curve (TIC) type and the apparent diffusion coefficient (ADC) value when b=500 s/mm2. The regression equation was Logit (P)=-21.936+20.478X6+3.267X7+ 21.488X3. Valuable indicators in the diagnosis of breast cancer are the edge feature of the tumor, the TIC type and the ADC value when b=500 s/mm2. Combining conventional MRI scan, DWI and dynamic enhanced MRI is a better examination program, while MRS is the complementary program when diagnosis is difficult.

Comparative evaluation of the VERSANT HCV RNA 3.0, QUANTIPLEX HCV RNA 2.0, and COBAS AMPLICOR HCV MONITOR version 2.0 Assays for quantification of hepatitis C virus RNA in serum.

PubMed

Germer, Jeffrey J; Heimgartner, Paul J; Ilstrup, Duane M; Harmsen, W Scott; Jenkins, Greg D; Patel, Robin

2002-02-01

A comparison of quantitative results expressed in hepatitis C virus (HCV) international units per milliliter, obtained from the VERSANT HCV RNA 3.0 (bDNA-3.0) assay, the QUANTIPLEX HCV RNA 2.0 (bDNA-2.0) assay, and the COBAS AMPLICOR HCV MONITOR version 2.0 (HCM-2.0) test was performed. A total of 168 patient specimens submitted to the Mayo Clinic Molecular Microbiology Laboratory for HCV quantification or HCV genotyping were studied. Of the specimens tested, 97, 88, and 79% yielded quantitative results within the dynamic range of the bDNA-3.0, bDNA-2.0, and HCM-2.0 assays, respectively. Overall, there was substantial agreement between the results generated by all three assays. A total of 15 out of 29 (52%) of the specimens determined to contain viral loads of <31,746 IU/ml by the bDNA-3.0 assay were categorized as containing viral loads within the range of 31,746 to 500,000 IU/ml by the bDNA-2.0 assay. Although substantial agreement was noted between the results generated by the bDNA-2.0 and bDNA-3.0 assays, a bias toward higher viral titer by the bDNA-2.0 assay was noted (P = 0.001). Likewise, although substantial agreement was noted between the results generated by the HCM-2.0 and bDNA-3.0 assays, a bias toward higher viral titer by the bDNA-3.0 assay was noted (P < or = 0.001). The discrepancy between the HCM-2.0 and bDNA-3.0 results was more pronounced when viral loads were >500,000 IU/ml and resulted in statistically significant differences (P < or = 0.001) in determining whether viral loads were above or below 800,000 IU/ml of HCV RNA, the proposed threshold value for tailoring the duration of combination therapy. The expression of quantitative values in HCV international units per milliliter was a strength of both the bDNA-3.0 and HCM-2.0 assays.

Comparative Evaluation of the VERSANT HCV RNA 3.0, QUANTIPLEX HCV RNA 2.0, and COBAS AMPLICOR HCV MONITOR Version 2.0 Assays for Quantification of Hepatitis C Virus RNA in Serum

PubMed Central

Germer, Jeffrey J.; Heimgartner, Paul J.; Ilstrup, Duane M.; Harmsen, W. Scott; Jenkins, Greg D.; Patel, Robin

2002-01-01

A comparison of quantitative results expressed in hepatitis C virus (HCV) international units per milliliter, obtained from the VERSANT HCV RNA 3.0 (bDNA-3.0) assay, the QUANTIPLEX HCV RNA 2.0 (bDNA-2.0) assay, and the COBAS AMPLICOR HCV MONITOR version 2.0 (HCM-2.0) test was performed. A total of 168 patient specimens submitted to the Mayo Clinic Molecular Microbiology Laboratory for HCV quantification or HCV genotyping were studied. Of the specimens tested, 97, 88, and 79% yielded quantitative results within the dynamic range of the bDNA-3.0, bDNA-2.0, and HCM-2.0 assays, respectively. Overall, there was substantial agreement between the results generated by all three assays. A total of 15 out of 29 (52%) of the specimens determined to contain viral loads of <31,746 IU/ml by the bDNA-3.0 assay were categorized as containing viral loads within the range of 31,746 to 500,000 IU/ml by the bDNA-2.0 assay. Although substantial agreement was noted between the results generated by the bDNA-2.0 and bDNA-3.0 assays, a bias toward higher viral titer by the bDNA-2.0 assay was noted (P = 0.001). Likewise, although substantial agreement was noted between the results generated by the HCM-2.0 and bDNA-3.0 assays, a bias toward higher viral titer by the bDNA-3.0 assay was noted (P ≤ 0.001). The discrepancy between the HCM-2.0 and bDNA-3.0 results was more pronounced when viral loads were >500,000 IU/ml and resulted in statistically significant differences (P ≤ 0.001) in determining whether viral loads were above or below 800,000 IU/ml of HCV RNA, the proposed threshold value for tailoring the duration of combination therapy. The expression of quantitative values in HCV international units per milliliter was a strength of both the bDNA-3.0 and HCM-2.0 assays. PMID:11825962

MR imaging of the temporomandibular joint: comparison between acquisitions at 7.0 T using dielectric pads and 3.0 T

PubMed Central

Kuhn, Felix P; Spinner, Georg; Del Grande, Filippo; Wyss, Michael; Piccirelli, Marco; Erni, Stefan; Pfister, Pascal; Ho, Michael; Sah, Bert-Ram; Filli, Lukas; Ettlin, Dominik A; Gallo, Luigi M; Andreisek, Gustav

2017-01-01

Objectives: To qualitatively and quantitatively compare MRI of the temporomandibular joint (TMJ) at 7.0 T using high-permittivity dielectric pads and 3.0 T using a clinical high-resolution protocol. Methods: Institutional review board-approved study with written informed consent. 12 asymptomatic volunteers were imaged at 7.0 and 3.0 T using 32-channel head coils. High-permittivity dielectric pads consisting of barium titanate in deuterated suspension were used for imaging at 7.0 T. Imaging protocol consisted of oblique sagittal proton density weighted turbo spin echo sequences. For quantitative analysis, pixelwise signal-to-noise ratio maps of the TMJ were calculated. For qualitative analysis, images were evaluated by two independent readers using 5-point Likert scales. Quantitative and qualitative results were compared using t-tests and Wilcoxon signed-rank tests, respectively. Results: TMJ imaging at 7.0 T using high-permittivity dielectric pads was feasible in all volunteers. Quantitative analysis showed similar signal-to-noise ratio for both field strengths (mean ± SD; 7.0 T, 13.02 ± 3.92; 3.0 T, 14.02 ± 3.41; two-sample t-tests, p = 0.188). At 7.0 T, qualitative analysis yielded better visibility of all anatomical subregions of the temporomandibular disc (anterior band, intermediate zone and posterior band) than 3.0 T (Wilcoxon signed-rank tests, p < 0.05, corrected for multiple comparisons). Conclusions: MRI of the TMJ at 7.0 T using high-permittivity dielectric pads yields superior visibility of the temporomandibular disc compared with 3.0 T. PMID:27704872

MR imaging of the temporomandibular joint: comparison between acquisitions at 7.0 T using dielectric pads and 3.0 T.

PubMed

Kuhn, Felix P; Spinner, Georg; Del Grande, Filippo; Wyss, Michael; Piccirelli, Marco; Erni, Stefan; Pfister, Pascal; Ho, Michael; Sah, Bert-Ram; Filli, Lukas; Ettlin, Dominik A; Gallo, Luigi M; Andreisek, Gustav; Manoliu, Andrei

2017-01-01

To qualitatively and quantitatively compare MRI of the temporomandibular joint (TMJ) at 7.0 T using high-permittivity dielectric pads and 3.0 T using a clinical high-resolution protocol. Institutional review board-approved study with written informed consent. 12 asymptomatic volunteers were imaged at 7.0 and 3.0 T using 32-channel head coils. High-permittivity dielectric pads consisting of barium titanate in deuterated suspension were used for imaging at 7.0 T. Imaging protocol consisted of oblique sagittal proton density weighted turbo spin echo sequences. For quantitative analysis, pixelwise signal-to-noise ratio maps of the TMJ were calculated. For qualitative analysis, images were evaluated by two independent readers using 5-point Likert scales. Quantitative and qualitative results were compared using t-tests and Wilcoxon signed-rank tests, respectively. TMJ imaging at 7.0 T using high-permittivity dielectric pads was feasible in all volunteers. Quantitative analysis showed similar signal-to-noise ratio for both field strengths (mean ± SD; 7.0 T, 13.02 ± 3.92; 3.0 T, 14.02 ± 3.41; two-sample t-tests, p = 0.188). At 7.0 T, qualitative analysis yielded better visibility of all anatomical subregions of the temporomandibular disc (anterior band, intermediate zone and posterior band) than 3.0 T (Wilcoxon signed-rank tests, p < 0.05, corrected for multiple comparisons). MRI of the TMJ at 7.0 T using high-permittivity dielectric pads yields superior visibility of the temporomandibular disc compared with 3.0 T.

Incremental Value of Plaque Enhancement in Patients with Moderate or Severe Basilar Artery Stenosis: 3.0 T High-Resolution Magnetic Resonance Study.

PubMed

Wang, Wanqian; Yang, Qi; Li, Debiao; Fan, Zhaoyang; Bi, Xiaoming; Du, Xiangying; Wu, Fang; Wu, Ye; Li, Kuncheng

2017-01-01

To investigate the clinical relevance of plaque's morphological characteristics and distribution pattern using 3.0 T high-resolution magnetic resonance imaging (HRMRI) in patients with moderate or severe basilar artery (BA) atherosclerosis stenosis. Fifty-seven patients (33 symptomatic patients and 24 asymptomatic patients) were recruited for 3.0 T HRMRI scan; all of them had >50% stenosis on the BA. The intraplaque hemorrhage (IPH), contrast-enhancement pattern, and distribution of BA plaques were compared between the symptomatic and asymptomatic groups. Factors potentially associated with posterior ischemic stroke were calculated by multivariate analyses. Enhancement of BA plaque was more frequently observed in symptomatic than in asymptomatic patients (27/33, 81.8% versus 11/24, 45.8%; p < 0.01). In multivariate regression analysis, plaque enhancement (OR = 7.193; 95% CI: 1.880-27.517; p = 0.004) and smoking (OR = 4.402; 95% CI: 2.218-15.909; p = 0.024) were found to be independent risk factors of posterior ischemic events in patients with BA stenosis >50%. Plaques were mainly distributed at the ventral site (39.3%) or involved more than two arcs (21.2%) in the symptomatic group but were mainly distributed at left (33.3%) and right (25.0%) sites in the asymptomatic group.

Validation Test Report For The CRWMS Analysis and Logistics Visually Interactive Model Calvin Version 3.0, 10074-Vtr-3.0-00

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. Gillespie

2000-07-27

This report describes the tests performed to validate the CRWMS ''Analysis and Logistics Visually Interactive'' Model (CALVIN) Version 3.0 (V3.0) computer code (STN: 10074-3.0-00). To validate the code, a series of test cases was developed in the CALVIN V3.0 Validation Test Plan (CRWMS M&O 1999a) that exercises the principal calculation models and options of CALVIN V3.0. Twenty-five test cases were developed: 18 logistics test cases and 7 cost test cases. These cases test the features of CALVIN in a sequential manner, so that the validation of each test case is used to demonstrate the accuracy of the input to subsequentmore » calculations. Where necessary, the test cases utilize reduced-size data tables to make the hand calculations used to verify the results more tractable, while still adequately testing the code's capabilities. Acceptance criteria, were established for the logistics and cost test cases in the Validation Test Plan (CRWMS M&O 1999a). The Logistics test cases were developed to test the following CALVIN calculation models: Spent nuclear fuel (SNF) and reactivity calculations; Options for altering reactor life; Adjustment of commercial SNF (CSNF) acceptance rates for fiscal year calculations and mid-year acceptance start; Fuel selection, transportation cask loading, and shipping to the Monitored Geologic Repository (MGR); Transportation cask shipping to and storage at an Interim Storage Facility (ISF); Reactor pool allocation options; and Disposal options at the MGR. Two types of cost test cases were developed: cases to validate the detailed transportation costs, and cases to validate the costs associated with the Civilian Radioactive Waste Management System (CRWMS) Management and Operating Contractor (M&O) and Regional Servicing Contractors (RSCs). For each test case, values calculated using Microsoft Excel 97 worksheets were compared to CALVIN V3.0 scenarios with the same input data and assumptions. All of the test case results compare with the

Datacasting V3.0

NASA Technical Reports Server (NTRS)

Bingham, Andrew W.; McCleese, Sean W.; Deen, Robert G.; Chung, Nga T.; Stough, Timothy M.

2013-01-01

Datacasting V3.0 provides an RSSbased feed mechanism for publishing the availability of Earth science data records in real time. It also provides a utility for subscribing to these feeds and sifting through all the items in an automatic manner to identify and download the data records that are required for a specific application. Datacasting is a method by which multiple data providers can publish the availability of new Earth science data and users download those files that meet a predefined need; for example, to only download data files related to a specific earthquake or region on the globe. Datacasting is a server-client architecture. The server-side software is used by data providers to create and publish the metadata about recently available data according to the Datacasting RSS (Really Simple Syndication) specification. The client software subscribes to the Datacasting RSS and other RSS-based feeds. By configuring filters associated with feeds, data consumers can use the client to identify and automatically download files that meet a specific need. On the client side, a Datacasting feed reader monitors the server for new feeds. The feed reader will be tuned by the user, via a graphical user interface (GUI), to examine the content of the feeds and initiate a data pull after some criteria are satisfied. The criteria might be, for example, to download sea surface temperature data for a particular region that has cloud cover less than 50% and during daylight hours. After the granule is downloaded to the client, the user will have the ability to visualize the data in the GUI. Based on the popular concept of podcasting, which gives listeners the capability to download only those MP3 files that match their preference, Earth science Datacasting will give users a method to download only the Earth science data files that are required for a particular application.

3.0-T functional brain imaging: a 5-year experience.

PubMed

Scarabino, T; Giannatempo, G M; Popolizio, T; Tosetti, M; d'Alesio, V; Esposito, F; Di Salle, F; Di Costanzo, A; Bertolino, A; Maggialetti, A; Salvolini, U

2007-02-01

The aim of this paper is to illustrate the technical, methodological and diagnostic features of functional imaging (comprising spectroscopy, diffusion, perfusion and cortical activation techniques) and its principal neuroradiological applications on the basis of the experience gained by the authors in the 5 years since the installation of a high-field magnetic resonance (MR) magnet. These MR techniques are particularly effective at 3.0 Tesla (T) owing to their high signal, resolution and sensitivity, reduced scanning times and overall improved diagnostic ability. In particular, the high-field strength enhances spectroscopic analysis due to a greater signal-to-noise ratio (SNR) and improved spectral, space and time resolution, resulting in the ability to obtain high-resolution spectroscopic studies not only of the more common metabolites, but also--and especially--of those which, due to their smaller concentrations, are difficult to detect using 1.5-T systems. All of these advantages can be obtained with reduced acquisition times. In diffusion studies, the high-field strength results in greater SNR, because 3.0-T magnets enable increased spatial resolution, which enhances accuracy. They also allow exploration in greater detail of more complex phenomena (such as diffusion tensor and tractography), which are not clearly depicted on 1.5-T systems. The most common perfusion study (with intravenous injection of a contrast agent) benefits from the greater SNR and higher magnetic susceptibility by achieving dramatically improved signal changes, and thus greater reliability, using smaller doses of contrast agent. Functional MR imaging (fMRI) is without doubt the modality in which high-field strength has had the greatest impact. Images acquired with the blood-oxygen-level-dependent (BOLD) technique benefit from the greater SNR afforded by 3.0-T magnets and from their stronger magnetic susceptibility effects, providing higher signal and spatial resolution. This enhances

Comparison between utility of the Thai Pediatric Quality of Life Inventory 4.0 Generic Core Scales and 3.0 Cerebral Palsy Module.

PubMed

Tantilipikorn, Pinailug; Watter, Pauline; Prasertsukdee, Saipin

2013-03-01

Health-related quality of life (HRQOL) is increasingly being considered in the management of patients with various conditions. HRQOL instruments can be broadly classified as generic or disease-specific measures. Several generic HRQOL instruments in different languages have been developed for paediatric populations including the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) Generic Core Scale. This tool and a condition-specific tool, PedsQL 3.0 Cerebral Palsy (CP) Module, are widely used in children with CP. No psychometric properties have been reported for Thai PedsQL 4.0. Therefore, this study aimed to explore the psychometric properties of the Thai version of the PedsQL 4.0 Generic Core Scales and compare these with the values for the Thai PedsQL 3.0 CP Module reported previously. Thai PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 CP Module were completed, respectively, by children with CP and their parents or caregivers twice within 2-4 weeks. Respondents were 97 parents or caregivers and 54 children. Minimal missing data were found in most scales. Acceptable internal consistency was supported, except for Emotional, Social, and School Functioning. Intraclass correlation coefficients for parent-proxy report and self-report were good to excellent (0.625-0.849). The feasibility and reliability of the Thai PedsQL 4.0 Generic Core Scales were supported. The Thai PedsQL 3.0 CP Module showed higher values for the psychometric properties. Low-to-good correlations were found among the scales between the PedsQL 4.0 Generic Core Scales and the 3.0 CP Module. Both instruments could be used to measure HRQOL for children with CP, and may provide different information.

A Quantitative Evaluation of SCEC Community Velocity Model Version 3.0

NASA Astrophysics Data System (ADS)

Chen, P.; Zhao, L.; Jordan, T. H.

2003-12-01

We present a systematic methodology for evaluating and improving 3D seismic velocity models using broadband waveform data from regional earthquakes. The operator that maps a synthetic waveform into an observed waveform is expressed in the Rytov form D(ω ) = {exp}[{i} ω δ τ {p}(ω ) - ω δ τ {q}(ω )]. We measure the phase delay time δ τ p(ω ) and the amplitude reduction time δ τ q(ω ) as a function of frequency ω using Gee & Jordan's [1992] isolation-filter technique, and we correct the data for frequency-dependent interference and frequency-independent source statics. We have applied this procedure to a set of small events in Southern California. Synthetic seismograms were computed using three types of velocity models: the 1D Standard Southern California Crustal Model (SoCaL) [Dreger & Helmberger, 1993], the 3D SCEC Community Velocity Model, Version 3.0 (CVM3.0) [Magistrale et al., 2000], and a set of path-averaged 1D models (A1D) extracted from CVM3.0 by horizontally averaging wave slownesses along source-receiver paths. The 3D synthetics were computed using K. Olsen's finite difference code. More than 1000 measurements were made on both P and S waveforms at frequencies ranging from 0.2 to 1 Hz. Overall, the 3D model provided a substantially better fit to the waveform data than either laterally homogeneous or path-dependent 1D models. Relative to SoCaL, CVM3.0 provided a variance reduction of about 64% in δ τ p, and 41% in δ τ q. Relative to A1D, the variance reduction is about 46% and 20%, respectively. The same set of measurements can be employed to invert for both seismic source properties and seismic velocity structures. Fully numerical methods are being developed to compute the Fréchet kernels for these measurements [L. Zhao et. al., this meeting]. This methodology thus provides a unified framework for regional studies of seismic sources and Earth structure in Southern California and elsewhere.

45 CFR 310.30 - Under what circumstances would FFP be suspended or disallowed in the costs of Computerized Tribal...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Under what circumstances would FFP be suspended or... SYSTEMS AND OFFICE AUTOMATION Funding for Computerized Tribal IV-D Systems and Office Automation § 310.30 Under what circumstances would FFP be suspended or disallowed in the costs of Computerized Tribal IV-D...

A combined oral contraceptive containing 30 mcg ethinyl estradiol and 3.0 mg drospirenone does not impair endothelium-dependent vasodilation

PubMed Central

Meendering, Jessica R.; Torgrimson, Britta N.; Miller, Nicole P.; Kaplan, Paul F.; Minson, Christopher T.

2010-01-01

Background Ethinyl estradiol (EE) increases endothelium-dependent vasodilation in young women, but certain progestins paired with EE in combination OCPs have been shown to antagonize the vasodilatory effects of EE. Therefore, the purpose of this study was to investigate how endothelial function, serum biomarkers, and resting blood pressures change across an OCP cycle in women using a monophasic OCP formulation containing the progestin drospirenone. Study Design Twelve women were studied during two hormone phases of their OCP cycle; once at the end of three weeks of active pills (30 mcg EE and 3.0 mg drospirenone), and once at the end of a week of placebo pills (no exogenous hormones). Results Endothelium-dependent vasodilation was greater during the active phase compared to the placebo phase (p < 0.001). In contrast, there was no difference in endothelium-independent dilation between hormone phases. Conclusion These data suggest that the combination of 30 mcg EE and 3.0 mg drospirenone used in the active phase of this OCP increases endothelium-dependent vasodilation compared to a placebo phase. PMID:20851231

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe.

PubMed

Gertz, E Michael; Chowdhury, Salim Akhter; Lee, Woei-Jyh; Wangsa, Darawalee; Heselmeyer-Haddad, Kerstin; Ried, Thomas; Schwartz, Russell; Schäffer, Alejandro A

2016-01-01

Advances in fluorescence in situ hybridization (FISH) make it feasible to detect multiple copy-number changes in hundreds of cells of solid tumors. Studies using FISH, sequencing, and other technologies have revealed substantial intra-tumor heterogeneity. The evolution of subclones in tumors may be modeled by phylogenies. Tumors often harbor aneuploid or polyploid cell populations. Using a FISH probe to estimate changes in ploidy can guide the creation of trees that model changes in ploidy and individual gene copy-number variations. We present FISHtrees 3.0, which implements a ploidy-based tree building method based on mixed integer linear programming (MILP). The ploidy-based modeling in FISHtrees includes a new formulation of the problem of merging trees for changes of a single gene into trees modeling changes in multiple genes and the ploidy. When multiple samples are collected from each patient, varying over time or tumor regions, it is useful to evaluate similarities in tumor progression among the samples. Therefore, we further implemented in FISHtrees 3.0 a new method to build consensus graphs for multiple samples. We validate FISHtrees 3.0 on a simulated data and on FISH data from paired cases of cervical primary and metastatic tumors and on paired breast ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). Tests on simulated data show improved accuracy of the ploidy-based approach relative to prior ploidyless methods. Tests on real data further demonstrate novel insights these methods offer into tumor progression processes. Trees for DCIS samples are significantly less complex than trees for paired IDC samples. Consensus graphs show substantial divergence among most paired samples from both sets. Low consensus between DCIS and IDC trees may help explain the difficulty in finding biomarkers that predict which DCIS cases are at most risk to progress to IDC. The FISHtrees software is available at ftp://ftp.ncbi.nih.gov/pub/FISHtrees.

Python as a federation tool for GENESIS 3.0.

PubMed

Cornelis, Hugo; Rodriguez, Armando L; Coop, Allan D; Bower, James M

2012-01-01

The GENESIS simulation platform was one of the first broad-scale modeling systems in computational biology to encourage modelers to develop and share model features and components. Supported by a large developer community, it participated in innovative simulator technologies such as benchmarking, parallelization, and declarative model specification and was the first neural simulator to define bindings for the Python scripting language. An important feature of the latest version of GENESIS is that it decomposes into self-contained software components complying with the Computational Biology Initiative federated software architecture. This architecture allows separate scripting bindings to be defined for different necessary components of the simulator, e.g., the mathematical solvers and graphical user interface. Python is a scripting language that provides rich sets of freely available open source libraries. With clean dynamic object-oriented designs, they produce highly readable code and are widely employed in specialized areas of software component integration. We employ a simplified wrapper and interface generator to examine an application programming interface and make it available to a given scripting language. This allows independent software components to be 'glued' together and connected to external libraries and applications from user-defined Python or Perl scripts. We illustrate our approach with three examples of Python scripting. (1) Generate and run a simple single-compartment model neuron connected to a stand-alone mathematical solver. (2) Interface a mathematical solver with GENESIS 3.0 to explore a neuron morphology from either an interactive command-line or graphical user interface. (3) Apply scripting bindings to connect the GENESIS 3.0 simulator to external graphical libraries and an open source three dimensional content creation suite that supports visualization of models based on electron microscopy and their conversion to computational models

FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe

PubMed Central

Chowdhury, Salim Akhter; Lee, Woei-Jyh; Wangsa, Darawalee; Heselmeyer-Haddad, Kerstin; Ried, Thomas; Schwartz, Russell; Schäffer, Alejandro A.

2016-01-01

Advances in fluorescence in situ hybridization (FISH) make it feasible to detect multiple copy-number changes in hundreds of cells of solid tumors. Studies using FISH, sequencing, and other technologies have revealed substantial intra-tumor heterogeneity. The evolution of subclones in tumors may be modeled by phylogenies. Tumors often harbor aneuploid or polyploid cell populations. Using a FISH probe to estimate changes in ploidy can guide the creation of trees that model changes in ploidy and individual gene copy-number variations. We present FISHtrees 3.0, which implements a ploidy-based tree building method based on mixed integer linear programming (MILP). The ploidy-based modeling in FISHtrees includes a new formulation of the problem of merging trees for changes of a single gene into trees modeling changes in multiple genes and the ploidy. When multiple samples are collected from each patient, varying over time or tumor regions, it is useful to evaluate similarities in tumor progression among the samples. Therefore, we further implemented in FISHtrees 3.0 a new method to build consensus graphs for multiple samples. We validate FISHtrees 3.0 on a simulated data and on FISH data from paired cases of cervical primary and metastatic tumors and on paired breast ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). Tests on simulated data show improved accuracy of the ploidy-based approach relative to prior ploidyless methods. Tests on real data further demonstrate novel insights these methods offer into tumor progression processes. Trees for DCIS samples are significantly less complex than trees for paired IDC samples. Consensus graphs show substantial divergence among most paired samples from both sets. Low consensus between DCIS and IDC trees may help explain the difficulty in finding biomarkers that predict which DCIS cases are at most risk to progress to IDC. The FISHtrees software is available at ftp://ftp.ncbi.nih.gov/pub/FISHtrees. PMID

Python as a Federation Tool for GENESIS 3.0

PubMed Central

Cornelis, Hugo; Rodriguez, Armando L.; Coop, Allan D.; Bower, James M.

2012-01-01

The GENESIS simulation platform was one of the first broad-scale modeling systems in computational biology to encourage modelers to develop and share model features and components. Supported by a large developer community, it participated in innovative simulator technologies such as benchmarking, parallelization, and declarative model specification and was the first neural simulator to define bindings for the Python scripting language. An important feature of the latest version of GENESIS is that it decomposes into self-contained software components complying with the Computational Biology Initiative federated software architecture. This architecture allows separate scripting bindings to be defined for different necessary components of the simulator, e.g., the mathematical solvers and graphical user interface. Python is a scripting language that provides rich sets of freely available open source libraries. With clean dynamic object-oriented designs, they produce highly readable code and are widely employed in specialized areas of software component integration. We employ a simplified wrapper and interface generator to examine an application programming interface and make it available to a given scripting language. This allows independent software components to be ‘glued’ together and connected to external libraries and applications from user-defined Python or Perl scripts. We illustrate our approach with three examples of Python scripting. (1) Generate and run a simple single-compartment model neuron connected to a stand-alone mathematical solver. (2) Interface a mathematical solver with GENESIS 3.0 to explore a neuron morphology from either an interactive command-line or graphical user interface. (3) Apply scripting bindings to connect the GENESIS 3.0 simulator to external graphical libraries and an open source three dimensional content creation suite that supports visualization of models based on electron microscopy and their conversion to computational

The use of and adherence to CTCAE v3.0 in cancer clinical trial publications.

PubMed

Zhang, Sheng; Chen, Qiang; Wang, Qing

2016-10-04

The Common Terminology Criteria for Adverse Events, Version 3.0 (CTCAE v3.0) was released in 2003, and has been widely used as the predominant set of toxicity criteria for cancer clinical trials and scientific meetings. However, the degree to which the elements of CTCAE v3.0 are followed in oncology publications has not been comprehensively evaluated. We reviewed phase III randomized clinical trials evaluating systemic cancer therapies, published between Jan 1, 2012 and December 31, 2013, to identify eligible studies that explicitly mentioned using CTCAE v3.0 as the toxicity criteria. A 10-point score based on adherence to CTCAE v3.0 was used to assess the studies. Multivariate linear regression was used to identify features associated with improved adherence. In total, 104 publications reporting data on 86,957 patients were included in this analysis. The mean total score for adherence to all four elements of CTCAE v3.0 was 4.03 on a 10-point scale (range, 1 to 9), with 16 publications (15%) having total scores ≤2. Highly heterogeneous and unstandardized adverse event terms were frequently used. In addition, Supra-ordinate terms, terms using 'Other, specify', and Grades were often used incorrectly. The multivariate regression model revealed that the absence of a placebo (P=0.003) and a higher total number of AE terms in the table (P<0.001) were independent predictors of a lower total score. Given the importance of understanding the toxicity of new treatments, better adherence to CTCAE v3.0 should be encouraged to ensure the consistency and comparability of toxicity data across different studies.

3.0 Tesla magnetic resonance imaging: A new standard in liver imaging?

PubMed Central

Girometti, Rossano

2015-01-01

An ever-increasing number of 3.0 Tesla (T) magnets are installed worldwide. Moving from the standard of 1.5 T to higher field strength implies a number of potential advantage and drawbacks, requiring careful optimization of imaging protocols or implementation of novel hardware components. Clinical practice and literature review suggest that state-of-the-art 3.0 T is equivalent to 1.5 T in the assessment of focal liver lesions and diffuse liver disease. Therefore, further technical improvements are needed in order to fully exploit the potential of higher field strength. PMID:26244063

3.0 Tesla magnetic resonance imaging: A new standard in liver imaging?

PubMed

Girometti, Rossano

2015-07-28

An ever-increasing number of 3.0 Tesla (T) magnets are installed worldwide. Moving from the standard of 1.5 T to higher field strength implies a number of potential advantage and drawbacks, requiring careful optimization of imaging protocols or implementation of novel hardware components. Clinical practice and literature review suggest that state-of-the-art 3.0 T is equivalent to 1.5 T in the assessment of focal liver lesions and diffuse liver disease. Therefore, further technical improvements are needed in order to fully exploit the potential of higher field strength.

Structural and magnetically enhanced ferroelectric properties of Nd3+ and Fe3+ substituted Pb(Zr0.45Ti0.55)O3 ceramics

NASA Astrophysics Data System (ADS)

Kaur, Randeep; Singh, Anupinder

2018-05-01

The influence of Nd3+ and Fe3+ substitution on Pb(Zr0.45Ti0.55)O3 composition prepared via solid state reaction route have been studied. The structural evolution was investigated using an X-ray diffraction (XRD). Non perovskite Pb2Ti2O7, ZrO2 and PbO phases were observed along with the rhombohedral phase. The SEM micrograph shows the surface morphology of the samples. The density of the sample was calculated by using Archimedes principle and found to be 8.45g/cm3. The magnetic data depicts the presence of both the ferromagnetic as well as antiferromagnetic character in the solid solution. In ferroelectric studies, the values of remnant polarization (Pr) and coercive field (Ec) enhanced from 2.60 μC/cm2 - 3.44 µC/cm2 and 15.82kV/cm - 22.91kV/cm respectively.

Switchable 3-0 magnetoelectric nanocomposite thin film with high coupling.

PubMed

McDannald, Austin; Ye, Linghan; Cantoni, Claudia; Gollapudi, Sreenivasulu; Srinivasan, Gopalan; Huey, Bryan D; Jain, Menka

2017-03-02

A mixed precursor solution method was used to deposit 3-0 nanocomposite thin films of PbZr 0.52 Ti 0.48 O 3 (PZT) and CoFe 2 O 4 (CFO). The piezoelectric behavior of PZT and magnetostrictive behavior of CFO allow for magnetoelectric (ME) coupling through strain transfer between the respective phases. High ME coupling is desired for many applications including memory devices, magnetic field sensors, and energy harvesters. The spontaneous phase separation in the 3-0 nanocomposite film was observed, with 25 nm CFO particle or nanophases distributed in discrete layers through the thickness of the PZT matrix. Magnetic-force microscopy images of the nanocomposite thin film under opposite magnetic poling conditions revealed in-plane pancake-like regions of higher concentration of the CFO nanoparticles. The constraints on the size and distribution of the CFO nanoparticles created a unique distribution in a PZT matrix and achieved values of ME coupling of 3.07 V cm -1 Oe -1 at a DC bias of 250 Oe and 1 kHz, increasing up to 25.0 V cm -1 Oe -1 at 90 kHz. Piezo-force microscopy was used to investigate the ferroelectric domain structure before and after opposite magnetic poling directions. It was found that in this nanocomposite, the polarization of the ferroelectric domains switched direction as a result of switching the direction of the magnetization by magnetic fields.

A medical informatics perspective on health informatics 3.0. Findings from the Yearbook 2011 section on health informatics 3.0.

PubMed

Ruch, P

2011-01-01

To summarize current advances of the so-called Web 3.0 and emerging trends of the semantic web. We provide a synopsis of the articles selected for the IMIA Yearbook 2011, from which we attempt to derive a synthetic overview of the today's and future activities in the field. while the state of the research in the field is illustrated by a set of fairly heterogeneous studies, it is possible to identify significant clusters. While the most salient challenge and obsessional target of the semantic web remains its ambition to simply interconnect all available information, it is interesting to observe the developments of complementary research fields such as information sciences and text analytics. The combined expression power and virtually unlimited data aggregation skills of Web 3.0 technologies make it a disruptive instrument to discover new biomedical knowledge. In parallel, such an unprecedented situation creates new threats for patients participating in large-scale genetic studies as Wjst demonstrate how various data set can be coupled to re-identify anonymous genetic information. The best paper selection of articles on decision support shows examples of excellent research on methods concerning original development of core semantic web techniques as well as transdisciplinary achievements as exemplified with literature-based analytics. This selected set of scientific investigations also demonstrates the needs for computerized applications to transform the biomedical data overflow into more operational clinical knowledge with potential threats for confidentiality directly associated with such advances. Altogether these papers support the idea that more elaborated computer tools, likely to combine heterogeneous text and data contents should soon emerge for the benefit of both experimentalists and hopefully clinicians.

Evaluation of the Dacos 3.0 analyser.

PubMed

Pons, J F; Alumá, A; Antoja, F; Biosca, C; Alsina, M J; Galimany, R

1990-01-01

The selective multitest Coulter Dacos 3.0 analyser was evaluated according to the guidelines of the Comisión de Instrumentación de la Sociedad Española de Química Clínica and of the European Committee for Clinical Laboratory Standards.THE EVALUATION WAS PERFORMED IN FOUR STEPS: examination of the analytical units; evaluation of routine working; study of interferences; and assessment of practicability.The evaluation included a photometric study. The inaccuracy is acceptable for 340 nm and 420 nm, and the imprecision at absorbances from 0.05 to 2.00 ranged from 0.06 to 0.28% at 340 nm and from 0.06 to 0.08% at 420 nm. The linearity showed some dispersion at low absorbance for PNP at 420 nm and the drift was negligible.The imprecision of the pipette delivery system, the temperature control system and the washing system were satisfactory.IN ROUTINE WORK CONDITIONS, SEVEN ANALYTICAL METHODS WERE STUDIED: glucose, creatinine, iron, total protein, AST, ALP and calcium. Within-run imprecision ranged, at low concentrations, from 0.9% (CV) for glucose, to 7.6% (CV) for iron; at medium concentrations, from 0.7% (CV) for total protein to 5.2% (CV) to creatinine; and at high concentrations, it ranged from 0.6% (CV) for glucose to 3.9% (CV) for ALP.Between-run imprecision at low concentrations ranged from 1.4% (CV) for glucose to 15.1% (CV) for iron; at medium concentrations it ranged from 1.2% (CV) for protein to 6.7% (CV) for iron; and at high concentrations the range is from l.2for AST to 5.7% (CV) for iron.No contamination was found in the sample carry-over study. Some contamination was found in the reagent carry-over study (total protein due to iron and calcium reagents). Relative inaccuracy is good for all the constituents assayed. Only LDH (high and low levels) and urate (low level) showed weak and negative interference caused by turbidity, and gamma-GT (high level) and amylase, bilirubin and ALP (two levels) showed a negative interference caused by haemolysis.

A comparable study of clinical and optical outcomes after 1.8, 2.0 mm microcoaxial and 3.0 mm coaxial cataract surgery.

PubMed

Yu, Yi-Bo; Zhu, Ya-Nan; Wang, Wei; Zhang, Yi-Dong; Yu, Yin-Hui; Yao, Ke

2016-01-01

To evaluate the clinical and optical outcomes after clear corneal incision cataract surgery (CICS) with three different incision sizes (1.8, 2.0 and 3.0 mm). Eyes of 150 patients with age-related cataract scheduled for coaxial cataract surgery were randomized to three groups: 1.8, 2.0, or 3.0 mm CICS. Intraoperative data and postoperative outcomes including surgically induced astigmatism (SIA), the corneal incision thickness, wavefront aberrations and modulation transfer function (MTF) of cornea were obtained. There were no significant differences among the three groups in demographic characteristics and intraoperative outcome. The 1.8 and 2.0 mm microincisions showed more satisfactory clinical outcomes than the 3.0 mm incision. The 1.8 mm incision showed significantly less SIA than the 2.0 mm incision until postoperative 1mo (P<0.05), but the difference was only 0.14-0.18 D. Combined with less increased incision thickness only at postoperative 1d (P=0.013), the 1.8 mm incision presented better uncorrected distance visual acuity (UCDVA) than the 2.0 mm incision only at 1d postoperatively (P=0.008). For higher-order aberrations and other Zernike coefficients, there were no significant differences between the 1.8 mm group and 2.0 mm group (P>0.05). Converting from 3.0 mm CICS to 1.8 or 2.0 mm CICS result in better clinical and optical outcomes. However, when incision is 1.8 mm, the benefits from further reduction in size compared with 2.0 mm are limited. The necessity to reduce the incision size is to be deliberated.

Spreading Dynamics and Interfacial Characteristics of Sn-3.0Ag-0.5Cu- xBi Melting on Cu Substrates

NASA Astrophysics Data System (ADS)

Xu, Bingsheng; Chen, Junwei; Yuan, Zhangfu; Zang, Likun; Zhang, Lina; Wu, Yan

2016-05-01

The effects of Bi addition on the properties of Sn-3.0Ag-0.5Cu molten alloy on Cu substrates are discussed using wettability and interface microstructure analysis. The changes of the contact angles between Sn-3.0Ag-0.5Cu- xBi and Cu substrates with the spreading time are described by Dezellus model. It indicates that the spreading process is governed by the interfacial reaction during the dwelling time. The interface microstructure is observed to clarify the effects of reactions on the spreading behavior. It is found that Cu6Sn5 is formed adjacent to the solder and Cu3Sn appears over the substrate with Bi added at 613K, indicating that Bi exists between the intermetallics and the addition of Bi can hinder the diffusion of copper towards the interior of the solder. Therefore the existence of Bi decreases the agglomeration of Cu-Sn grains. The growth of intermetallics is thus limited and the shape of intermetallics transforms from scallop to zigzag consequently. However, the segregation phenomenon appears when the additive amount of Bi is more than 5.5mass %, which could lead to the occurrence of fracture and degrade the performance of Sn-3.0Ag-0.5Cu- xBi alloy. The results of the present study provide basic physical and chemical data for the application of lead-free solder in the future microgravity space environment.

Evaluation of Droplet Splashing Algorithm in LEWICE 3.0

NASA Technical Reports Server (NTRS)

Homenko, Hilary N.

2004-01-01

The Icing Branch at NASA Glenn Research has developed a computer program to simulate ice formation on the leading edge of an aircraft wing during flight through cold, moist air. As part of the branch's current research, members have developed software known as LEWICE. This program is capable of predicting the formation of ice under designated weather conditions. The success of LEWICE is an asset to airplane manufacturers, ice protection system manufacturers, and the airline industry. Simulations of ice formation conducted in the tunnel and in flight is costly and time consuming. However, the danger of in-flight icing continues to be a concern for both commercial and military pilots. The LEWICE software is a step towards inexpensive and time efficient prediction of ice collection. In the most recent version of the program, LEWICE contains an algorithm for droplet splashing. Droplet splashing is a natural occurrence that causes accumulation of ice on aircraft surfaces. At impingement water droplets lose a portion of their mass to splashing. With part of each droplet joining the airflow and failing to freeze, early versions of LEWICE without the splashing algorithm over-predicted the collection of ice on the leading edge. The objective of my project was to determine whether the revised version of LEWICE accurately reflected the ice collection data obtained from the Icing Research Tunnel (IRT). The experimental data from the IRT was collected by Mark Potapczuk in January, March and July of 2001 and April and December of 2002. Experimental data points were the result of ice tracings conducted shortly after testing in the tunnel. Run sheets, which included a record of velocity, temperature, liquid water content and droplet diameter, served as the input of the LEWICE computer program. Parameters identical to the tunnel conditions were used to run LEWICE 2.0 and LEWICE 3.0. The results from IRT and versions of LEWICE were compared graphically. After entering the raw

Diagnostic reliability of 3.0-T MRI for detecting osseous abnormalities of the temporomandibular joint.

PubMed

Sawada, Kunihiko; Amemiya, Toshihiko; Hirai, Shigenori; Hayashi, Yusuke; Suzuki, Toshihiro; Honda, Masahiko; Sisounthone, Johnny; Matsumoto, Kunihito; Honda, Kazuya

2018-01-01

We compared the diagnostic reliability of 3.0-T magnetic resonance imaging (MRI) for detection of osseous abnormalities of the temporomandibular joint (TMJ) with that of the gold standard, cone-beam computed tomography (CBCT). Fifty-six TMJs were imaged with CBCT and MRI, and images of condyles and fossae were independently assessed for the presence of osseous abnormalities. The accuracy, sensitivity, and specificity of 3.0-T MRI were 0.88, 1.0, and 0.73, respectively, in condyle evaluation and 0.91, 0.75, and 0.95 in fossa evaluation. The McNemar test showed no significant difference (P > 0.05) between MRI and CBCT in the evaluation of osseous abnormalities in condyles and fossae. The present results indicate that 3.0-T MRI is equal to CBCT in the diagnostic evaluation of osseous abnormalities of the mandibular condyle.

Constitutive Behavior of Mixed Sn-Pb/Sn-3.0Ag-0.5Cu Solder Alloys

NASA Astrophysics Data System (ADS)

Tucker, J. P.; Chan, D. K.; Subbarayan, G.; Handwerker, C. A.

2012-03-01

During the transition from Pb-containing solders to Pb-free solders, joints composed of a mixture of Sn-Pb and Sn-Ag-Cu often result from either mixed assemblies or rework. Comprehensive characterization of the mechanical behavior of these mixed solder alloys resulting in a deformationally complete constitutive description is necessary to predict failure of mixed alloy solder joints. Three alloys with 1 wt.%, 5 wt.%, and 20 wt.% Pb were selected so as to represent reasonable ranges of Pb contamination expected from different 63Sn-37Pb components mixed with Sn-3.0Ag-0.5Cu. Creep and displacement-controlled tests were performed on specially designed assemblies at temperatures of 25°C, 75°C, and 125°C using a double lap shear test setup that ensures a nearly homogeneous state of plastic strain at the joint interface. The observed changes in creep and tensile behavior with Pb additions were related to phase equilibria and microstructure differences observed through differential scanning calorimetric and scanning electron microscopic cross-sectional analysis. As Pb content increased, the steady-state creep strain rates increased, and primary creep decreased. Even 1 wt.% Pb addition was sufficient to induce substantially large creep strains relative to the Sn-3.0Ag-0.5Cu alloy. We describe rate-dependent constitutive models for Pb-contaminated Sn-Ag-Cu solder alloys, ranging from the traditional time-hardening creep model to the viscoplastic Anand model. We illustrate the utility of these constitutive models by examining the inelastic response of a chip-scale package (CSP) under thermomechanical loading through finite-element analysis. The models predict that, as Pb content increases, total inelastic dissipation decreases.

HMDB 3.0--The Human Metabolome Database in 2013.

PubMed

Wishart, David S; Jewison, Timothy; Guo, An Chi; Wilson, Michael; Knox, Craig; Liu, Yifeng; Djoumbou, Yannick; Mandal, Rupasri; Aziat, Farid; Dong, Edison; Bouatra, Souhaila; Sinelnikov, Igor; Arndt, David; Xia, Jianguo; Liu, Philip; Yallou, Faizath; Bjorndahl, Trent; Perez-Pineiro, Rolando; Eisner, Roman; Allen, Felicity; Neveu, Vanessa; Greiner, Russ; Scalbert, Augustin

2013-01-01

The Human Metabolome Database (HMDB) (www.hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of the human metabolome. Since its first release in 2007, the HMDB has been used to facilitate research for nearly 1000 published studies in metabolomics, clinical biochemistry and systems biology. The most recent release of HMDB (version 3.0) has been significantly expanded and enhanced over the 2009 release (version 2.0). In particular, the number of annotated metabolite entries has grown from 6500 to more than 40,000 (a 600% increase). This enormous expansion is a result of the inclusion of both 'detected' metabolites (those with measured concentrations or experimental confirmation of their existence) and 'expected' metabolites (those for which biochemical pathways are known or human intake/exposure is frequent but the compound has yet to be detected in the body). The latest release also has greatly increased the number of metabolites with biofluid or tissue concentration data, the number of compounds with reference spectra and the number of data fields per entry. In addition to this expansion in data quantity, new database visualization tools and new data content have been added or enhanced. These include better spectral viewing tools, more powerful chemical substructure searches, an improved chemical taxonomy and better, more interactive pathway maps. This article describes these enhancements to the HMDB, which was previously featured in the 2009 NAR Database Issue. (Note to referees, HMDB 3.0 will go live on 18 September 2012.).

The New NASA Orbital Debris Engineering Model ORDEM 3.0

NASA Technical Reports Server (NTRS)

Krisko, P. H.

2014-01-01

The NASA Orbital Debris Program Office (ODPO) has released its latest Orbital Debris Engineering Model, ORDEM 3.0. It supersedes ORDEM 2.0. This newer model encompasses the Earth satellite and debris flux environment from altitudes of low Earth orbit (LEO) through geosynchronous orbit (GEO). Debris sizes of 10 microns through 1 m in non-GEO and 10 cm through 1 m in GEO are modeled. The inclusive years are 2010 through 2035. The ORDEM model series has always been data driven. ORDEM 3.0 has the benefit of many more hours from existing data sources and from new sources that weren't available to past versions. Returned surfaces, ground tests, and remote sensors all contribute data. The returned surface and ground test data reveal material characteristics of small particles. Densities of fragmentation debris particles smaller than 10 cm are grouped in ORDEM 3.0 in terms of high-, medium-, and lowdensities, along with RORSAT sodium-potassium droplets. Supporting models have advanced significantly. The LEO-to-GEO ENvironment Debris model (LEGEND) includes an historical and a future projection component with yearly populations that include launched and maneuvered intacts, mission related debris (MRD), and explosion and collision fragments. LEGEND propagates objects with ephemerides and physical characteristics down to 1 mm in size. The full LEGEND yearly population acts as an a priori condition for a Bayesian statistical model. Specific, well defined populations are added like the Radar Ocean Reconnaissance Satellite (RORSAT) sodium-potassium (NaK) droplets, recent major accidental and deliberate collision fragments, and known anomalous debris event fragments. For microdebris of sizes 10 microns to 1 mm the ODPO uses an in-house Degradation/Ejecta model in which a MLE technique is used with returned surface data to estimate populations. This paper elaborates on the upgrades of this model over previous versions highlighting the material density splits and consequences of

The New NASA Orbital Debris Engineering Model ORDEM 3.0

NASA Technical Reports Server (NTRS)

Krisko, P. H.

2014-01-01

The NASA Orbital Debris Program Office (ODPO) has released its latest Orbital Debris Engineering Model, ORDEM 3.0. It supersedes ORDEM 2000, now referred to as ORDEM 2.0. This newer model encompasses the Earth satellite and debris flux environment from altitudes of low Earth orbit (LEO) through geosynchronous orbit (GEO). Debris sizes of 10 micron through larger than 1 m in non-GEO and 10 cm through larger than 1 m in GEO are available. The inclusive years are 2010 through 2035. The ORDEM model series has always been data driven. ORDEM 3.0 has the benefit of many more hours of data from existing sources and from new sources than past ORDEM versions. The object data range in size from 10 µm to larger than 1 m, and include in situ and remote measurements. The in situ data reveals material characteristics of small particles. Mass densities are grouped in ORDEM 3.0 in terms of 'high-density', represented by 7.9 g/cc, 'medium-density' represented by 2.8 g/cc and 'low-density' represented by 1.4 g/cc. Supporting models have also advanced significantly. The LEO-to-GEO ENvironment Debris model (LEGEND) includes an historical and a future projection component with yearly populations that include launched and maneuvered intact spacecraft and rocket bodies, mission related debris, and explosion and collision event fragments. LEGEND propagates objects with ephemerides and physical characteristics down to 1 mm in size. The full LEGEND yearly population acts as an a priori condition for a Bayesian statistical model. Specific populations are added from sodium potassium droplet releases, recent major accidental and deliberate collisions, and known anomalous debris events. This paper elaborates on the upgrades of this model over previous versions. Sample validation results with remote and in situ measurements are shown, and the consequences of including material density are discussed as it relates to heightened risks to crewed and robotic spacecraft

Procedures and Standards Handbook. Version 3.0. What Works Clearinghouse

ERIC Educational Resources Information Center

What Works Clearinghouse, 2014

2014-01-01

This "What Works Clearinghouse Procedures and Standards Handbook (Version 3.0)" provides a detailed description of the standards and procedures of the What Works Clearinghouse (WWC). The remaining chapters of this Handbook are organized to take the reader through the basic steps that the WWC uses to develop a review protocol, identify…

Development and Validation of the Nursing Home Minimum Data Set 3.0 Mortality Risk Score (MRS3).

PubMed

Thomas, Kali S; Ogarek, Jessica A; Teno, Joan M; Gozalo, Pedro L; Mor, Vincent

2018-03-05

To develop a score to predict mortality using the Minimum Data Set 3.0 (MDS 3.0) that can be readily calculated from items collected during nursing home (NH) residents' admission assessments. We developed a training cohort of Medicare beneficiaries newly admitted to U.S. NHs during 2012 (N=1,426,815) and a testing cohort from 2013 (N=1,160,964). Data came from the MDS 3.0 assessments linked to the Medicare Beneficiary Summary File. Using the training dataset, we developed a composite MDS 3.0 Mortality Risk Score (MRS3) consisting of 17 clinical items and patients' age groups based on their relation to 30-day mortality. We assessed the calibration and discrimination of the MRS3 in predicting 30-day and 60-day mortality and compared its performance to the Charlson Comorbidity Index and the clinician's assessment of 6-month prognosis measured at admission. The 30-day and 60-day mortality rate for the testing population was 2.8% and 5.6%, respectively. Results from logistic regression models suggest that the MRS3 performed well in predicting death within 30 and 60 days (C-Statistics of 0.744 (95%CL = 0.741, 0.747) and 0.709 (95%CL=0.706, 0.711), respectively). The MRS3 was a superior predictor of mortality compared to the Charlson Comorbidity Index (C-statistics of 0.611 (95%CL=0.607, 0.615) and 0.608 (95%CL=0.605, 0.610)) and the clinicians' assessments of patients' 6-month prognoses (C-statistics of 0.543 (95%CL=0.542, 0.545) and 0.528 (95%CL=0.527, 0.529). The MRS3 is a good predictor of mortality and can be useful in guiding decision-making, informing plans of care, and adjusting for patients' risk of mortality.

30 CFR 57.22236 - Actions at 1.0 percent methane (VI mines).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Actions at 1.0 percent methane (VI mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22236 Actions at 1.0 percent methane (VI mines). If methane reaches 1.0 percent in the mine atmosphere, all persons other than...

30 CFR 57.22239 - Actions at 2.0 percent methane (IV mines).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Actions at 2.0 percent methane (IV mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22239 Actions at 2.0 percent methane (IV mines). If methane reaches 2.0 percent in the mine atmosphere, all persons other than...

30 CFR 57.22239 - Actions at 2.0 percent methane (IV mines).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Actions at 2.0 percent methane (IV mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22239 Actions at 2.0 percent methane (IV mines). If methane reaches 2.0 percent in the mine atmosphere, all persons other than...

30 CFR 57.22236 - Actions at 1.0 percent methane (VI mines).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Actions at 1.0 percent methane (VI mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22236 Actions at 1.0 percent methane (VI mines). If methane reaches 1.0 percent in the mine atmosphere, all persons other than...

Research of aerial imaging spectrometer data acquisition technology based on USB 3.0

NASA Astrophysics Data System (ADS)

Huang, Junze; Wang, Yueming; He, Daogang; Yu, Yanan

2016-11-01

With the emergence of UAV (unmanned aerial vehicle) platform for aerial imaging spectrometer, research of aerial imaging spectrometer DAS(data acquisition system) faces new challenges. Due to the limitation of platform and other factors, the aerial imaging spectrometer DAS requires small-light, low-cost and universal. Traditional aerial imaging spectrometer DAS system is expensive, bulky, non-universal and unsupported plug-and-play based on PCIe. So that has been unable to meet promotion and application of the aerial imaging spectrometer. In order to solve these problems, the new data acquisition scheme bases on USB3.0 interface.USB3.0 can provide guarantee of small-light, low-cost and universal relying on the forward-looking technology advantage. USB3.0 transmission theory is up to 5Gbps.And the GPIF programming interface achieves 3.2Gbps of the effective theoretical data bandwidth.USB3.0 can fully meet the needs of the aerial imaging spectrometer data transmission rate. The scheme uses the slave FIFO asynchronous data transmission mode between FPGA and USB3014 interface chip. Firstly system collects spectral data from TLK2711 of high-speed serial interface chip. Then FPGA receives data in DDR2 cache after ping-pong data processing. Finally USB3014 interface chip transmits data via automatic-dma approach and uploads to PC by USB3.0 cable. During the manufacture of aerial imaging spectrometer, the DAS can achieve image acquisition, transmission, storage and display. All functions can provide the necessary test detection for aerial imaging spectrometer. The test shows that system performs stable and no data lose. Average transmission speed and storage speed of writing SSD can stabilize at 1.28Gbps. Consequently ,this data acquisition system can meet application requirements for aerial imaging spectrometer.

Validation of an e-Learning 3.0 Critical Success Factors Framework: A Qualitative Research

ERIC Educational Resources Information Center

Miranda, Paula; Isaias, Pedro; Costa, Carlos J.; Pifano, Sara

2017-01-01

Aim/Purpose: As e-Learning 3.0 evolves from a theoretical construct into an actual solution for online learning, it becomes crucial to accompany this progress by scrutinising the elements that are at the origin of its success. Background: This paper outlines a framework of e-Learning 3.0's critical success factors and its empirical validation.…

SMART Structures User's Guide - Version 3.0

NASA Technical Reports Server (NTRS)

Spangler, Jan L.

1996-01-01

Version 3.0 of the Solid Modeling Aerospace Research Tool (SMART Structures) is used to generate structural models for conceptual and preliminary-level aerospace designs. Features include the generation of structural elements for wings and fuselages, the integration of wing and fuselage structural assemblies, and the integration of fuselage and tail structural assemblies. The highly interactive nature of this software allows the structural engineer to move quickly from a geometry that defines a vehicle's external shape to one that has both external components and internal components which may include ribs, spars, longerons, variable depth ringframes, a floor, a keel, and fuel tanks. The geometry that is output is consistent with FEA requirements and includes integrated wing and empennage carry-through and frame attachments. This report provides a comprehensive description of SMART Structures and how to use it.

45 CFR 98.30 - Parental choice.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.30 Parental choice. (a) The parent or parents of an eligible child who receives or is offered child care services shall be... available to a parent. (b) When a parent elects to enroll the child with a provider that has a grant or...

45 CFR 98.30 - Parental choice.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.30 Parental choice. (a) The parent or parents of an eligible child who receives or is offered child care services shall be... available to a parent. (b) When a parent elects to enroll the child with a provider that has a grant or...

45 CFR 98.30 - Parental choice.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.30 Parental choice. (a) The parent or parents of an eligible child who receives or is offered child care services shall be... available to a parent. (b) When a parent elects to enroll the child with a provider that has a grant or...

45 CFR 98.30 - Parental choice.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.30 Parental choice. (a) The parent or parents of an eligible child who receives or is offered child care services shall be... available to a parent. (b) When a parent elects to enroll the child with a provider that has a grant or...

45 CFR 98.30 - Parental choice.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Program Operations (Child Care Services)-Parental Rights and Responsibilities § 98.30 Parental choice. (a) The parent or parents of an eligible child who receives or is offered child care services shall be... available to a parent. (b) When a parent elects to enroll the child with a provider that has a grant or...

ms 2: A molecular simulation tool for thermodynamic properties, release 3.0

NASA Astrophysics Data System (ADS)

Rutkai, Gábor; Köster, Andreas; Guevara-Carrion, Gabriela; Janzen, Tatjana; Schappals, Michael; Glass, Colin W.; Bernreuther, Martin; Wafai, Amer; Stephan, Simon; Kohns, Maximilian; Reiser, Steffen; Deublein, Stephan; Horsch, Martin; Hasse, Hans; Vrabec, Jadran

2017-12-01

A new version release (3.0) of the molecular simulation tool ms 2 (Deublein et al., 2011; Glass et al. 2014) is presented. Version 3.0 of ms 2 features two additional ensembles, i.e. microcanonical (NVE) and isobaric-isoenthalpic (NpH), various Helmholtz energy derivatives in the NVE ensemble, thermodynamic integration as a method for calculating the chemical potential, the osmotic pressure for calculating the activity of solvents, the six Maxwell-Stefan diffusion coefficients of quaternary mixtures, statistics for sampling hydrogen bonds, smooth-particle mesh Ewald summation as well as the ability to carry out molecular dynamics runs for an arbitrary number of state points in a single program execution.

ORDEM 3.0 and MASTER-2009 Modeled Small Debris Population Comparison

NASA Technical Reports Server (NTRS)

Krisko, P. H.; Flegel, S.

2014-01-01

The latest versions of the two premier orbital debris engineering models, NASA's ORDEM 3.0 and ESA's MASTER-2009, have been publically released. Both models have gone through significant advancements since inception, and now represent the state-of-the-art in orbital debris knowledge of their respective agencies. The purpose of these models is to provide satellite designers/operators and debris researchers with reliable estimates of the artificial debris environment in low Earth orbit (LEO) to geosynchronous orbit (GEO). The small debris environment within the size range of 1 mm to 1 cm is of particular interest to both human and robotic spacecraft programs, particularly in LEO. These objects are much more numerous than larger trackable debris and can have enough momentum to cause significant, if not catastrophic, damage to spacecraft upon impact. They are also small enough to elude routine detection by existing observation systems (radar and telescope). Without reliable detection the modeling of these populations has always coupled theoretical origins with supporting observational data in different degrees. In this paper, we present and detail the 1 mm to 1 cm orbital debris populations from both ORDEM 3.0 and MASTER-2009 in LEO. We review population categories: particle sources for MASTER-2009, particle densities for ORDEM 3.0. We describe data sources and their uses, and supporting models. Fluxes on spacecraft for chosen orbits are also presented and discussed within the context of each model.

Magnetic resonance angiography of fetal vasculature at 3.0 T.

PubMed

Neelavalli, Jaladhar; Krishnamurthy, Uday; Jella, Pavan K; Mody, Swati S; Yadav, Brijesh K; Hendershot, Kelly; Hernandez-Andrade, Edgar; Yeo, Lami; Cabrera, Maria D; Haacke, Ewart M; Hassan, Sonia S; Romero, Roberto

2016-12-01

Magnetic resonance angiography has not been used much previously for visualizing fetal vessels in utero for reasons that include a contraindication for the use of exogenous contrast agents, maternal respiratory motion and fetal motion. In this work, we report the feasibility of using an appropriately modified clinical time-of-flight magnetic resonance imaging sequence for non-contrast angiography of human fetal and placental vessels at 3.0 T. Using this 2D angiography technique, it is possible to visualize fetal vascular networks in late pregnancy. • 3D-visualization of fetal vasculature is feasible using non-contrast MRA at 3.0 T. • Visualization of placental vasculature is also possible with this method. • Fetal MRA can serve as a vascular localizer for quantitative MRI studies. • This method can be extended to 1.5 T.

45 CFR 1801.30 - Continuation into graduate study.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 1801.30 Public Welfare Regulations Relating to Public Welfare (Continued) HARRY S. TRUMAN SCHOLARSHIP FOUNDATION HARRY S. TRUMAN SCHOLARSHIP PROGRAM Graduate Study § 1801.30 Continuation into graduate study. (a... Foundation does not conduct a competition for graduate scholarships and does not add new Truman Scholars at...

45 CFR 1801.30 - Continuation into graduate study.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 1801.30 Public Welfare Regulations Relating to Public Welfare (Continued) HARRY S. TRUMAN SCHOLARSHIP FOUNDATION HARRY S. TRUMAN SCHOLARSHIP PROGRAM Graduate Study § 1801.30 Continuation into graduate study. (a... Foundation does not conduct a competition for graduate scholarships and does not add new Truman Scholars at...

45 CFR 1801.30 - Continuation into graduate study.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 1801.30 Public Welfare Regulations Relating to Public Welfare (Continued) HARRY S. TRUMAN SCHOLARSHIP FOUNDATION HARRY S. TRUMAN SCHOLARSHIP PROGRAM Graduate Study § 1801.30 Continuation into graduate study. (a... Foundation does not conduct a competition for graduate scholarships and does not add new Truman Scholars at...

Comparison of the Bayer VERSANT HCV RNA 3.0 and the Roche COBAS Amplicor HCV Monitor, Version 2.0, assays in HCV genotype 4 infection.

PubMed

Jessner, W; Watkins-Riedel, T; Müller, C; Formann, E; Gschwantler, M; Ferenci, P

2007-11-01

Prediction of treatment response is clinically important in chronic hepatitis C virus (HCV) genotype 4 infection. Early viral kinetics is useful in this respect for genotype 1 but interpretation is dependent on assay linearity and reproducibility. The VERSANT HCV RNA 3.0 (bDNA-3.0) and the COBAS Amplicor HCV Monitor 2.0 (HCM-2.0) have been widely used quantitative assays. We wanted to comparatively evaluate the two tests in a large genotype 4 sample. Genotyping was performed by NS5b sequencing. Viral load was tested in parallel in 32 patients at least six times on antiviral therapy with interferon alpha (IFNalpha). Totally, 198 samples within a quantitative range from undetectable to about 7 x 10(6) IU/mL (bDNA-3.0) were obtained and compared. Twenty-two samples with viral load above 500 000 IU/mL tested by HCM-2.0 were 1:100 diluted and retested. Quantitative values were fitted to a third order polynomial (M = 0.118303 + 1.07503 x V+ 0.0112128 x V(2) - 0.0055504 x V(3); M...HCM-2.0, V...bDNA-3.0, both log IU/mL) showing progressive nonlinearity of HCM-2.0 above 100 000 IU/mL but better clinical sensitivity with respect to bDNA-3.0. Dilution lead to a gain of at least a factor of 2.7 and thus, overestimation compared with bDNA-3.0. Deviation from linearity and overestimation upon dilution by HCM-2.0 are similar with HCV genotype 4, compared with other HCV genotypes. Differences in test performance were not detected for subtypes but for individual patients possibly related to specific quasi-species patterns. The interpretation of viral kinetic data becomes difficult due to overestimation upon dilution of baseline values by HCM-2.0.

Histogram analysis of apparent diffusion coefficient at 3.0 T in urinary bladder lesions: correlation with pathologic findings.

PubMed

Suo, Shi-Teng; Chen, Xiao-Xi; Fan, Yu; Wu, Lian-Ming; Yao, Qiu-Ying; Cao, Meng-Qiu; Liu, Qiang; Xu, Jian-Rong

2014-08-01

To investigate the potential value of histogram analysis of apparent diffusion coefficient (ADC) obtained at standard (700 s/mm(2)) and high (1500 s/mm(2)) b values on a 3.0-T scanner in the differentiation of bladder cancer from benign lesions and in assessing bladder tumors of different pathologic T stages and to evaluate the diagnostic performance of ADC-based histogram parameters. In all, 52 patients with bladder lesions, including benign lesions (n = 7) and malignant tumors (n = 45; T1 stage or less, 23; T2 stage, 7; T3 stage, 8; and T4 stage, 7), were retrospectively evaluated. Magnetic resonance examination at 3.0 T and diffusion-weighted imaging were performed. ADC maps were obtained at two b values (b = 700 and 1500 s/mm(2); ie, ADC-700 and ADC-1500). Parameters of histogram analysis included mean, kurtosis, skewness, and entropy. The correlations between these parameters and pathologic results were revealed. Receiver operating characteristic (ROC) curves were generated to determine the diagnostic value of histogram parameters. Significant differences were found in mean ADC-700, mean ADC-1500, skewness ADC-1500, and kurtosis ADC-1500 between bladder cancer and benign lesions (P = .002-.032). There were also significant differences in mean ADC-700, mean ADC-1500, and kurtosis ADC-1500 among bladder tumors of different pathologic T stages (P = .000-.046). No significant differences were observed in other parameters. Mean ADC-1500 and kurtosis ADC-1500 were significantly correlated with T stage, respectively (ρ = -0.614, P < .001; ρ = 0.374, P = .011). ROC analysis showed that the combination of mean ADC-1500 and kurtosis ADC-1500 has the maximal area under the ROC curve (AUC, 0.894; P < .001) in the differentiation of benign lesions and malignant tumors, with a sensitivity of 77.78% and specificity of 100%. AUCs for differentiating low- and high-stage tumors were 0.840 for mean ADC-1500 (P < .001) and 0.696 for kurtosis ADC-1500 (P�

Frequency dispersion of longitudinal ultrasonic velocity and attenuation in [001]c-poled 0.24Pb(In₁/₂Nb₁/₂O₃- 0.45Pb(Mg₁/₃Nb₂/₃)O₃-0.31PbTiO₃ single crystal.

PubMed

Sun, Enwei; Cao, Wenwu; Han, Pengdi

2011-08-01

The frequency dispersion of ultrasonic velocity and attenuation in [001](c)-poled 0.24Pb(in(1/2)Nb(1/2))O(3)-0.45Pb(Mg(1/3)Nb(2/3))o(3)-0.31PbTio(3) (PIN-0.45PMN-0.31PT) ternary single crystal were measured by ultrasonic spectroscopy from 25 to 100 MHz for the longitudinal wave. It was found that the velocity has a linear relationship with the frequency f, but the attenuation has a quadratic relation with f. The attenuation and frequency dispersion of the ternary system are lower than that of the (1-x)Pb(Mg(1/3)Nb(2/3))O(3)-xPbTiO(3) (PMN-PT) binary system and the coercive field also increased by a factor of 2.5, hence, the ternary single system is superior to the corresponding binary single-crystal system for high-frequency and high-power transducer applications.

A combined oral contraceptive containing 30 mcg ethinyl estradiol and 3.0 mg drospirenone does not impair endothelium-dependent vasodilation.

PubMed

Meendering, Jessica R; Torgrimson, Britta N; Miller, Nicole P; Kaplan, Paul F; Minson, Christopher T

2010-10-01

Ethinyl estradiol (EE) increases endothelium-dependent vasodilation in young women, but certain progestins paired with EE in combination oral contraceptive pills (OCPs) have been shown to antagonize the vasodilatory effects of EE. Therefore, the purpose of this study was to investigate how endothelial function, serum biomarkers and resting blood pressures change across an OCP cycle in women using a monophasic OCP formulation containing the progestin drospirenone. Twelve women were studied during two hormone phases of their OCP cycle: once at the end of 3 weeks of active pills (30 mcg EE and 3.0 mg drospirenone) and once at the end of a week of placebo pills (no exogenous hormones) Endothelium-dependent vasodilation was greater during the active phase compared to the placebo phase (p<.001). In contrast, there was no difference in endothelium-independent dilation between hormone phases. These data suggest that the combination of 30 mcg EE and 3.0 mg drospirenone used in the active phase of this OCP increases endothelium-dependent vasodilation compared to a placebo phase. Copyright © 2010 Elsevier Inc. All rights reserved.

40 CFR 45.150 - Reports.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Reports. 45.150 Section 45.150... ASSISTANCE § 45.150 Reports. (a) Recipients must submit the reports required in 40 CFR 30.505. (b) A draft of the final project report is required 90 days before the end of the project period. The recipient shall...

40 CFR 45.150 - Reports.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Reports. 45.150 Section 45.150... ASSISTANCE § 45.150 Reports. (a) Recipients must submit the reports required in 40 CFR 30.505. (b) A draft of the final project report is required 90 days before the end of the project period. The recipient shall...

Version 3.0 of EMINERS - Economic Mineral Resource Simulator

USGS Publications Warehouse

Duval, Joseph S.

2012-01-01

Quantitative mineral resource assessment, as developed by the U.S. Geological Survey (USGS), consists of three parts: (1) development of grade and tonnage mineral deposit models; (2) delineation of tracts permissive for each deposit type; and (3) probabilistic estimation of the numbers of undiscovered deposits for each deposit type. The estimate of the number of undiscovered deposits at different levels of probability is the input to the EMINERS (Economic Mineral Resource Simulator) program. EMINERS uses a Monte Carlo statistical process to combine probabilistic estimates of undiscovered mineral deposits with models of mineral deposit grade and tonnage to estimate mineral resources. Version 3.0 of the EMINERS program is available as this USGS Open-File Report 2004-1344. Changes from version 2.0 include updating 87 grade and tonnage models, designing new templates to produce graphs showing cumulative distribution and summary tables, and disabling economic filters. The economic filters were disabled because embedded data for costs of labor and materials, mining techniques, and beneficiation methods are out of date. However, the cost algorithms used in the disabled economic filters are still in the program and available for reference for mining methods and milling techniques. The release notes included with this report give more details on changes in EMINERS over the years. EMINERS is written in C++ and depends upon the Microsoft Visual C++ 6.0 programming environment. The code depends heavily on the use of Microsoft Foundation Classes (MFC) for implementation of the Windows interface. The program works only on Microsoft Windows XP or newer personal computers. It does not work on Macintosh computers. For help in using the program in this report, see the "Quick-Start Guide for Version 3.0 of EMINERS-Economic Mineral Resource Simulator" (W.J. Bawiec and G.T. Spanski, 2012, USGS Open-File Report 2009-1057, linked at right). It demonstrates how to execute EMINERS software

Data Quality Assurance and Provenance Tracking in ICOADS Release 3.0

NASA Astrophysics Data System (ADS)

Cram, T.; Worley, S. J.; Ji, Z.; Schuster, D.

2017-12-01

The International Comprehensive Ocean-Atmosphere Data Set (ICOADS) Release 3.0 (R3.0) is the world's most extensive collection of global surface marine meteorological in situ observational data. Managed under an international partnership, it contains over 455 million unique multi-parameter records, dates back to 1662, and is updated monthly in near real-time. It is a foundational dataset for weather and climate research that has been used by thousands of users. By using rigorous data preparation methods, new IT infrastructure, and International Maritime Meteorological Archive (IMMA) format enhancements, ICOADS R3.0 is exemplary in data quality assurance, provenance tracking, and capturing user feedback. The features in this data lifecycle management will be presented and include, but are not limited to, written data translation specification for each data source being added to ICOADS, assignment of data source identification parameters, attachment of the original data in the IMMA format to support future re-evaluation if necessary, permanently assigned unique identification on every record making data development and community collaborations easily possible using a relational database infrastructure, and extensible capacity of the IMMA format to augment the data richness beyond the primary scope of marine surface data. Some recent augmentations are more completely specified ocean observations from profiling observing systems, feedback data submitted by the atmospheric and oceanographic reanalysis providers, higher quality edited cloud reports, and community provided data value adjustments with uncertainty estimates. Highlights covering these ICOADS value-added features will be explained and the open free access from NCAR will be briefly described.

A DFT study of ethanol adsorption and decomposition on α-Al2O3(0 0 0 1) surface

NASA Astrophysics Data System (ADS)

Chiang, Hsin-Ni; Nachimuthu, Santhanamoorthi; Cheng, Ya-Chin; Damayanti, Nur Pradani; Jiang, Jyh-Chiang

2016-02-01

Ethanol adsorption and decomposition on the clean α-Al2O3(0 0 0 1) surface have been systematically investigated by density functional theory calculations. The nature of the surface-ethanol bonding has studied through the density of states (DOS) and the electron density difference (EDD) contour plots. The DOS patterns confirm that the lone pair electrons of EtOH are involved in the formation of a surface Alsbnd O dative bond and the EDD plots provide evidences for the bond weakening/forming, which are consistent with the DOS analysis. Our ethanol decomposition results indicate that ethanol dehydration to ethylene (CH3CH2OH(a) → C2H4(g) + OH(a) + H(a)), is the main reaction pathway with the energy barrier of 1.46 eV. Although the cleavage of the hydroxyl group of ethanol has lower energy barrier, the further decomposition of ethoxy owns much higher energy barrier.

Gold as hydrogen: Structural and electronic properties and chemical bonding in Si3Au3+/0/- and comparisons to Si3H3+/0/-

NASA Astrophysics Data System (ADS)

Kiran, Boggavarapu; Li, Xi; Zhai, Hua-Jin; Wang, Lai-Sheng

2006-10-01

A single Au atom has been shown to behave like H in its bonding to Si in several mono- and disilicon gold clusters. In the current work, we investigate the Au /H analogy in trisilicon gold clusters, Si3Au3+/0/-. Photoelectron spectroscopy and density functional calculations are combined to examine the geometric and electronic structure of Si3Au3-. We find that there are three isomers competing for the ground state of Si3Au3- as is the case for Si3H3-. Extensive structural searches show that the potential energy surfaces of the trisilicon gold clusters (Si3Au3-, Si3Au3, and Si3Au3+) are similar to those of the corresponding silicon hydrides. The lowest energy isomers for Si3Au3- and Si3Au3 are structurally similar to a Si3Au four-membered ring serving as a common structural motif. For Si3Au3+, the 2π aromatic cyclotrisilenylium auride ion, analogous to the aromatic cyclotrisilenylium ion (Si3H3+), is the most stable species. Comparison of the structures and chemical bonding between Si3Au3+/0/- and the corresponding silicon hydrides further extends the isolobal analogy between Au and H.

Compendium of fruit fly host information (CoFFHI), edition 3.0

USDA-ARS?s Scientific Manuscript database

The Compendium of Fruit Fly Host Information (CoFFHI), edition 3.0 (available at: https://coffhi.cphst.org/), developed through collaborative efforts of scientists in USDA-APHIS, USDA-ARS, and the Center for Integrated Pest Management (CIPM) of North Carolina State University (NCSU), provides centra...

Cultural adaptation and validation of Stroke Impact Scale 3.0 version in Uganda: A small-scale study.

PubMed

Kamwesiga, Julius T; von Koch, Lena; Kottorp, Anders; Guidetti, Susanne

2016-01-01

Knowledge is scarce about the impact of stroke in Uganda, and culturally adapted, psychometrically tested patient-reported outcome measures are lacking. The Stroke Impact Scale 3.0 is recommended, but it has not been culturally adapted and validated in Uganda. To culturally adapt and determine the psychometric properties of the Stroke Impact Scale 3.0 in the Ugandan context on a small scale. The Stroke Impact Scale 3.0 was culturally adapted to form Stroke Impact Scale 3.0 Uganda ( in English ) by involving 25 participants in three different expert committees. Subsequently, Stroke Impact Scale 3.0 Uganda from English to Luganda language was done in accordance with guidelines. The first language in Uganda is English and Luganda is the main spoken language in Kampala city and its surroundings. Translation of Stroke Impact Scale 3.0 Uganda ( both in English and Luganda ) was then tested psychometrically by applying a Rasch model on data collected from 95 participants with stroke. Overall, 10 of 59 (17%) items in the eight domains of the Stroke Impact Scale 3.0 were culturally adapted. The majority were 6 of 10 items in the domain Activities of Daily Living, 2 of 9 items in the domain Mobility, and 2 of 5 items in the domain Hand function. Only in two domains, all items demonstrated acceptable goodness of fit to the Rasch model. There were also more than 5% person misfits in the domains Participation and Emotion, while the Communication, Mobility, and Hand function domains had the lowest proportions of person misfits. The reliability coefficient was equal or larger than 0.90 in all domains except the Emotion domain, which was below the set criterion of 0.80 (0.75). The cultural adaptation and translation of Stroke Impact Scale 3.0 Uganda provides initial evidence of validity of the Stroke Impact Scale 3.0 when used in this context. The results provide support for several aspects of validity and precision but also point out issues for further adaptation and improvement

k-t SENSE-accelerated Myocardial Perfusion MR Imaging at 3.0 Tesla - comparison with 1.5 Tesla

PubMed Central

Plein, Sven; Schwitter, Juerg; Suerder, Daniel; Greenwood, John P.; Boesiger, Peter; Kozerke, Sebastian

2008-01-01

Purpose To determine the feasibility and diagnostic accuracy of high spatial resolution myocardial perfusion MR at 3.0 Tesla using k-space and time domain undersampling with sensitivity encoding (k-t SENSE). Materials and Methods The study was reviewed and approved by the local ethic review board. k-t SENSE perfusion MR was performed at 1.5 Tesla and 3.0 Tesla (saturation recovery gradient echo pulse sequence, repetition time/echo time 3.0ms/1.0ms, flip angle 15°, 5x k-t SENSE acceleration, spatial resolution 1.3×1.3×10mm3). Fourteen volunteers were studied at rest and 37 patients during adenosine stress. In volunteers, comparison was also made with standard-resolution (2.5×2.5×10mm3) 2x SENSE perfusion MR at 3.0 Tesla. Image quality, artifact scores, signal-to-noise ratios (SNR) and contrast-enhancement ratios (CER) were derived. In patients, diagnostic accuracy of visual analysis to detect >50% diameter stenosis on quantitative coronary angiography was determined by receiver-operator-characteristics (ROC). Results In volunteers, image quality and artifact scores were similar for 3.0 Tesla and 1.5 Tesla, while SNR was higher (11.6 vs. 5.6) and CER lower (1.1 vs. 1.5, p=0.012) at 3.0 Tesla. Compared with standard-resolution perfusion MR, image quality was higher for k-t SENSE (3.6 vs. 3.1, p=0.04), endocardial dark rim artifacts were reduced (artifact thickness 1.6mm vs. 2.4mm, p<0.001) and CER similar. In patients, area under the ROC curve for detection of coronary stenosis was 0.89 and 0.80, p=0.21 for 3.0 Tesla and 1.5 Tesla, respectively. Conclusions k-t SENSE accelerated high-resolution perfusion MR at 3.0 Tesla is feasible with similar artifacts and diagnostic accuracy as at 1.5 Tesla. Compared with standard-resolution perfusion MR, image quality is improved and artifacts are reduced. PMID:18936311

Projectile-charge-state dependence of 0[degree] binary-encounter electron production in 30-MeV O[sup [ital q]+]+O[sub 2] collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zouros, T.J.M.; Richard, P.; Wong, K.L.

Double-differential cross sections (DDCS's) for the production of binary-encounter electrons (BEE's) are reported for 30-MeV O[sup [ital q]+]+O[sub 2] collisions. The BEE DDCS's were measured at [theta]=0[degree] with respect to the beam direction for projectile charge states [ital q]=4--8. The measured BEE DDCS's were found to increase with decreasing charge state in agreement with other recent BEE results employing simpler H[sub 2] and He targets. Impulse-approximation calculations of BEE production for [theta]=0[degree]--45[degree] are also presented, in which it is assumed that target electrons undergo elastic scattering in the screened Coulomb field of the projectile ion. These calculations are shown tomore » be in agreement with our data at [theta]=0[degree] where only 2[ital s] and 2[ital p] target electrons are considered.« less

A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodies.

PubMed

Singh, Susheel K; Roeffen, Will; Andersen, Gorm; Bousema, Teun; Christiansen, Michael; Sauerwein, Robert; Theisen, Michael

2015-04-15

The sexual stage Pfs48/45 antigen is a well-established lead candidate for a transmission blocking (TB) vaccine because of its critical role in parasite fertilization. We have recently produced the carboxy-terminal 10C-fragment of Pfs48/45 containing three known epitopes for TB antibodies as a chimera with the N-terminal region of GLURP (R0). The resulting fusion protein elicited high titer TB antibodies in rodents. To increase the relatively low yield of correctly folded Pfs48/45 we have generated a series of novel chimera truncating the 10C-fragments to 6 cysteine residues containing sub-units (6C). All constructs harbor the major epitope I for TB antibodies. One of these sub-units (R0.6Cc), produced high yields of correctly folded conformers, which could be purified by a simple 2-step procedure. Purified R0.6Cc was stable and elicits high titer TB antibodies in rats. The yield, purity and stability of R0.6Cc allows for further clinical development. Copyright © 2015 Elsevier Ltd. All rights reserved.

40 CFR 503.45 - Management practices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Management practices. 503.45 Section 503.45 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STANDARDS FOR THE USE OR DISPOSAL OF SEWAGE SLUDGE Incineration § 503.45 Management practices. (a)(1) An...

40 CFR 503.45 - Management practices.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Management practices. 503.45 Section 503.45 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STANDARDS FOR THE USE OR DISPOSAL OF SEWAGE SLUDGE Incineration § 503.45 Management practices. (a)(1) An...

A multiple antibiotic and serum resistant oligotrophic strain, Klebsiella pneumoniae MB45 having novel dfrA30, is sensitive to ZnO QDs

PubMed Central

2011-01-01

Background The aim of this study was to describe a novel trimethoprim resistance gene cassette, designated dfrA30, within a class 1 integron in a facultatively oligotrophic, multiple antibiotic and human serum resistant test strain, MB45, in a population of oligotrophic bacteria isolated from the river Mahananda; and to test the efficiency of surface bound acetate on zinc oxide quantum dots (ZnO QDs) as bactericidal agent on MB45. Methods Diluted Luria broth/Agar (10-3) media was used to cultivate the oligotrophic bacteria from water sample. Multiple antibiotic resistant bacteria were selected by employing replica plate method. A rapid assay was performed to determine the sensitivity/resistance of the test strain to human serum. Variable region of class 1 integron was cloned, sequenced and the expression of gene coding for antibiotic resistance was done in Escherichia coli JM 109. Identity of culture was determined by biochemical phenotyping and 16S rRNA gene sequence analyses. A phylogenetic tree was constructed based on representative trimethoprim resistance-mediating DfrA proteins retrieved from GenBank. Growth kinetic studies for the strain MB45 were performed in presence of varied concentrations of ZnO QDs. Results and conclusions The facultatively oligotrophic strain, MB45, resistant to human serum and ten antibiotics trimethoprim, cotrimoxazole, ampicillin, gentamycin, netilmicin, tobramycin, chloramphenicol, cefotaxime, kanamycin and streptomycin, has been identified as a new strain of Klebsiella pneumoniae. A novel dfr gene, designated as dfrA30, found integrated in class 1 integron was responsible for resistance to trimethoprim in Klebsiella pneumoniae strain MB45. The growth of wild strain MB45 was 100% arrested at 500 mg/L concentration of ZnO QDs. To our knowledge this is the first report on application of ZnO quantum dots to kill multiple antibiotics and serum resistant K. pneumoniae strain. PMID:21595893

Results of an investigation to determine local flow characteristics at the air data probe locations using an 0.030-scale model (45-0) of the space shuttle vehicle orbiter configuration 140A/B (modified) in the NASA Ames Research Center unitary plan wind tunnel (OA161, A, B, C), volume 1

NASA Technical Reports Server (NTRS)

Nichols, M. E.

1976-01-01

Results are presented of wind tunnel test 0A161 of a 0.030-scale model 45-0 of the configuration 140A/B (modified) space shuttle vehicle orbiter in the NASA Ames Research Center Unitary Plan Wind Tunnel facilities. The purpose of this test was to determine local total and static pressure environments for the air data probe locations and relative effectiveness of alternate flight-test probe configurations. Testing was done in the Mach number range from 0.30 to 3.5. Angle of attack was varied from -8 to 25 degrees while sideslip varied between -8 and 8 degrees.

Esophageal carcinoma: Ex vivo evaluation by high-spatial-resolution T2 -mapping MRI compared with histopathological findings at 3.0T.

PubMed

Wei, Yi; Wu, Sen; Gao, Feifei; Sun, Tingyi; Zheng, Dandan; Ning, Peigang; Zhao, Cuihua; Li, Ziyuan; Li, Xiaodong; Li, Linlin; Zhu, Shaocheng

2017-06-01

To prospectively determine the feasibility of T 2 -mapping magnetic resonance imaging (MRI) to quantitatively describe the signal characteristics of the normal esophageal wall and assess the depth of esophageal wall invasion by carcinoma at 3.0T. Thirty-two patient specimens, each having foci of carcinoma, were studied using 3.0T MR. Freehand regions of interest were placed to measure the T 2 value of the normal esophageal layers and were compared with the regions of carcinoma. Three independent readers reviewed the MR images to evaluate the depth of carcinoma invasion; when the three radiologists could not fully agree with each other, the final stage was determined by consensus. The Games-Howell test was used to compare the difference between the normal esophageal layers and carcinoma. Spearman correlation coefficient analysis was used to compare the stage at MRI with that at histopathological analysis. The interobserver agreement was compared with Cohen's kappa. The sensitivity, specificity, and accuracy for detecting carcinoma invasion were calculated. The T 2 values between the carcinoma and normal esophageal layers were different (all P < 0.01), except for the inner circular muscle (P = 0.511). The T 2 value of each layer of the normal esophageal wall was also different from that of the adjacent layer (all P < 0.01). In 29 of 32 lesions, the depth of the esophageal wall invasion determined by MR was consistent with the histopathological stage (r = 0.969, P < 0.001). The sensitivity, specificity, and accuracy were 80%, 96.3%, and 93.8%, respectively, for invasion into the mucosa; 77.8%, 95.7%, and 90.6%, respectively, for invasion into submucosa; 100%, 95.8%, and 96.9%, respectively, for invasion into muscularis propria; and 100%, 100%, and 100%, respectively, for invasion into the adventitia. T 2 -mapping MR images obtained using a 3.0T MR scanner can be used to depict the precise histopathological layers of the esophageal wall clearly and provide

[Expression and clinical significance of CD45RO in laryngeal carcinoma tissue].

PubMed

Li, Manyi; Liu, Jishengi; Zhou, Hui; Wu, Wenying; Xiao, Gensheng; Yu, Yafeng; Guo, Lingchuan

2014-03-01

To investigate the role and significance of CD45RO in occurance and development in laryngeal squamous carcinoma, and to provide some valuable clues for searching new approaches to assess prognosis and theoretical basis for tumor biotherapy. The expression of CD45RO protein in 50 cases of laryngeal squamous carcinoma and 10 cases normal mucos was detected by immunohistochemical S-P method. The positive rate of CD45RO was 30% and 86% respectively in normal tissue and laryngeal squamous cell carcinoma tissue. The expresion of CD45RO was significantly and negatively associated with local metastatic of lymph nodes 0.713, P < 0.05) and tumor sites (r = -0.750, P < 0.05), but it have no notable difference with pathology differentiation, age, infiltrating depth and clinical stages in 50 cases of laryngeal squamous cell cancer. (1) The expresion of CD45RO in laryngeal squamous cell cancer is more than that in normal tissue. (2) It is possible that overexpresion of CD45RO in laryngeal squamous cell carcinoma cut local metastatic lymph nodes. (3) It is probable that overexpresion of CD45RO in laryngeal squamous cell cancer made for prognosis of patients. (4) Other than UICC-TNM stage, pathology differentiation, it provide valuable clues for searching new approaches to assess prognosis of laryngeal squamous cell carcinoma.

Cross sections for the γp→K*0Σ+ reaction at Eγ=1.7 3.0 GeV

NASA Astrophysics Data System (ADS)

Hleiqawi, I.; Hicks, K.; Carman, D. S.; Mibe, T.; Niculescu, G.; Tkabladze, A.; Amarian, M.; Ambrozewicz, P.; Anghinolfi, M.; Asryan, G.; Avakian, H.; Bagdasaryan, H.; Baillie, N.; Ball, J. P.; Baltzell, N. A.; Batourine, V.; Battaglieri, M.; Beard, K.; Bedlinskiy, I.; Bellis, M.; Benmouna, N.; Berman, B. L.; Biselli, A. S.; Bouchigny, S.; Boiarinov, S.; Bradford, R.; Branford, D.; Briscoe, W. J.; Brooks, W. K.; Bültmann, S.; Burkert, V. D.; Butuceanu, C.; Calarco, J. R.; Careccia, S. L.; Carnahan, B.; Chen, S.; Cole, P. L.; Collins, P.; Coltharp, P.; Crabb, D.; Crannell, H.; Crede, V.; Cummings, J. P.; Masi, R. De; Vita, R. De; Sanctis, E. De; Degtyarenko, P. V.; Dennis, L.; Deur, A.; Djalali, C.; Dickson, R.; Dodge, G. E.; Donnelly, J.; Doughty, D.; Dugger, M.; Dytman, S.; Dzyubak, O. P.; Egiyan, H.; Egiyan, K. S.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Feldman, G.; Fersch, R.; Feuerbach, R.; Garçon, M.; Gavalian, G.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Gonenc, A.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Gyurjyan, V.; Hakobyan, R. S.; Hardie, J.; Heddle, D.; Hersman, F. W.; Holtrop, M.; Hyde-Wright, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Ito, M. M.; Jenkins, D.; Jo, H. S.; Joo, K.; Juengst, H. G.; Kalantarians, N.; Kellie, J. D.; Khandaker, M.; Kim, K.; Kim, W.; Klein, A.; Klein, F. J.; Klimenko, A. V.; Kossov, M.; Krahn, Z.; Kramer, L. H.; Kubarovsky, V.; Kuhn, J.; Kuhn, S. E.; Kuleshov, S. V.; Lachniet, J.; Laget, J. M.; Langheinrich, J.; Lawrence, D.; Li, J.; Livingston, K.; Lu, H. Y.; Lukashin, K.; MacCormick, M.; McAleer, S.; McKinnon, B.; McNabb, J.; Mecking, B. A.; Mestayer, M. D.; Meyer, C. A.; Mikhailov, K.; Minehart, R.; Mirazita, M.; Miskimen, R.; Mokeev, V.; Moriya, K.; Morrow, S. A.; Moteabbed, M.; Mutchler, G. S.; Munevar, E.; Nadel-Turonski, P.; Nasseripour, R.; Niccolai, S.; Niculescu, I.; Niczyporuk, B. B.; Niroula, M. R.; Niyazov, R. A.; Nozar, M.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Paterson, C.; Pierce, J.; Pivnyuk, N.; Pogorelko, O.; Pozdniakov, S.; Preedom, B.; Price, J. W.; Prok, Y.; Protopopescu, D.; Raue, B. A.; Riccardi, G.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Ronchetti, F.; Rosner, G.; Rossi, P.; Sabatié, F.; Salgado, C.; Santoro, J. P.; Sapunenko, V.; Schumacher, R. A.; Serov, V. S.; Sharabian, Y. G.; Smith, E. S.; Smith, L. C.; Sober, D. I.; Stavinsky, A.; Stepanyan, S. S.; Stepanyan, S.; Stokes, B. E.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Taylor, S.; Tedeschi, D. J.; Thoma, U.; Thompson, R.; Todor, L.; Tkachenko, S.; Tur, C.; Ungaro, M.; Vineyard, M. F.; Vlassov, A. V.; Wang, K.; Weinstein, L. B.; Weygand, D. P.; Whisnant, S.; Williams, M.; Wolin, E.; Wood, M. H.; Yegneswaran, A.; Zana, L.; Zhang, J.; Zhao, B.; Zhao, Z.

2007-04-01

Differential cross sections for the reaction γp→K*0Σ+ are presented in the photon energy range of 1.7 to 3.0 GeV. The K*0 was detected by its decay products, K+π-, in the Continuous Electron Beam Accelerator Facility's large acceptance spectrometer (CLAS) detector at the Thomas Jefferson National Accelerator Facility. These data are the first K*0 photoproduction cross sections ever published over a broad range of angles. Comparison with a theoretical model based on the vector and tensor K*-quark couplings shows good agreement with the data, except at forward angles, suggesting that the role of scalar κ meson exchange should be investigated.

The Effects of Antimony Addition on the Microstructural, Mechanical, and Thermal Properties of Sn-3.0Ag-0.5Cu Solder Alloy

NASA Astrophysics Data System (ADS)

Sungkhaphaitoon, Phairote; Plookphol, Thawatchai

2018-02-01

In this study, we investigated the effects produced by the addition of antimony (Sb) to Sn-3.0Ag-0.5Cu-based solder alloys. Our focus was the alloys' microstructural, mechanical, and thermal properties. We evaluated the effects by means of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), differential scanning calorimetry (DSC), and a universal testing machine (UTM). The results showed that a part of the Sb was dissolved in the Sn matrix phase, and the remaining one participated in the formation of intermetallic compounds (IMCs) of Ag3(Sn,Sb) and Cu6(Sn,Sb)5. In the alloy containing the highest wt pct Sb, the added component resulted in the formation of SnSb compound and small particle pinning of Ag3(Sn,Sb) along the grain boundary of the IMCs. Our tests of the Sn-3.0Ag-0.5Cu solder alloys' mechanical properties showed that the effects produced by the addition of Sb varied as a function of the wt pct Sb content. The ultimate tensile strength (UTS) increased from 29.21 to a maximum value of 40.44 MPa, but the pct elongation (pct EL) decreased from 48.0 to a minimum 25.43 pct. Principally, the alloys containing Sb had higher UTS and lower pct EL than Sb-free solder alloys due to the strengthening effects of solid solution and second-phase dispersion. Thermal analysis showed that the alloys containing Sb had a slightly higher melting point and that the addition amount ranging from 0.5 to 3.0 wt pct Sb did not significantly change the solidus and liquidus temperatures compared with the Sb-free solder alloys. Thus, the optimal concentration of Sb in the alloys was 3.0 wt pct because the microstructure and the ultimate tensile strength of the SAC305 solder alloys were improved.

Cultural adaptation and validation of Stroke Impact Scale 3.0 version in Uganda: A small-scale study

PubMed Central

Kamwesiga, Julius T; von Koch, Lena; Kottorp, Anders; Guidetti, Susanne

2016-01-01

Background: Knowledge is scarce about the impact of stroke in Uganda, and culturally adapted, psychometrically tested patient-reported outcome measures are lacking. The Stroke Impact Scale 3.0 is recommended, but it has not been culturally adapted and validated in Uganda. Objective: To culturally adapt and determine the psychometric properties of the Stroke Impact Scale 3.0 in the Ugandan context on a small scale. Method: The Stroke Impact Scale 3.0 was culturally adapted to form Stroke Impact Scale 3.0 Uganda (in English) by involving 25 participants in three different expert committees. Subsequently, Stroke Impact Scale 3.0 Uganda from English to Luganda language was done in accordance with guidelines. The first language in Uganda is English and Luganda is the main spoken language in Kampala city and its surroundings. Translation of Stroke Impact Scale 3.0 Uganda (both in English and Luganda) was then tested psychometrically by applying a Rasch model on data collected from 95 participants with stroke. Results: Overall, 10 of 59 (17%) items in the eight domains of the Stroke Impact Scale 3.0 were culturally adapted. The majority were 6 of 10 items in the domain Activities of Daily Living, 2 of 9 items in the domain Mobility, and 2 of 5 items in the domain Hand function. Only in two domains, all items demonstrated acceptable goodness of fit to the Rasch model. There were also more than 5% person misfits in the domains Participation and Emotion, while the Communication, Mobility, and Hand function domains had the lowest proportions of person misfits. The reliability coefficient was equal or larger than 0.90 in all domains except the Emotion domain, which was below the set criterion of 0.80 (0.75). Conclusion: The cultural adaptation and translation of Stroke Impact Scale 3.0 Uganda provides initial evidence of validity of the Stroke Impact Scale 3.0 when used in this context. The results provide support for several aspects of validity and precision but also point

Sputtering characteristics, crystal structures, and transparent conductive properties of TiOxNy films deposited on α-Al2O3(0 0 0 1) and glass substrates

NASA Astrophysics Data System (ADS)

Akazawa, Housei

2012-12-01

Adding N2 gas during reactive sputtering of a Ti target prevented the target surface from being severely poisoned by oxygen atoms and sustained a high deposition rate for titanium oxynitride films under metal-mode-like sputtering conditions. With progress in the degree of oxidization, films deposited onto a glass substrate varied from TiO1-xNx having a face-centered cubic (fcc) structure to TiO2-xNx having an anatase structure. Titanium oxynitride films deposited on an Al2O3(0 0 0 1) substrate were epitaxial with major orientations toward the (1 1 1) and (2 0 0) directions for fcc-TiO1-xNx and (1 1 2) for anatase-TiO2-xNx. Intermediately oxidized films between TiO1-xNx and TiO2-xNx were amorphous on the glass substrate but crystallized into a Magneli phase, TinO(N)2n-1, on the Al2O3(0 0 0 1) substrate. Partially substituting oxygen in TiO2 with nitrogen as well as continuously irradiating the growing film surface with a Xe plasma stream preferentially formed anatase rather than rutile. However, the occupation of anion sites with enough oxygen rather than nitrogen was the required condition for anatase crystals to form. The transparent conductive properties of epitaxial TiO2-xNx films on Al2O3(0 0 0 1) were superior to those of microcrystalline films on the glass substrate. Since resistivity and optical transmittance of TiOxNy films vary continuously with changing N2 flow rate, their transparent conductive properties can be controlled more easily than TiOx. Nb5+ ions could be doped as donors in TiO2-xNx anatase crystals.

Corrective Action Decision Document/Closure Report for Corrective Action Unit 375: Area 30 Buggy Unit Craters, Nevada National Security Site, Nevada, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patrick Matthews

2011-08-01

Corrective Action Unit 375 comprises three corrective action sites (CASs): (1) 25-23-22, Contaminated Soils Site; (2) 25-34-06, Test Cell A Bunker; and (3) 30-45-01, U-30a, b, c, d, e Craters. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 375 based on the implementation of corrective action of closure in place with administrative controls at CAS 25-23-22, no further action at CAS 25-34-06, and closure in place with administrative controls and removal of potential source material (PSM) at CAS 30-45-01. Corrective action investigation (CAI) activities weremore » performed from July 28, 2010, through April 4, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 375: Area 30 Buggy Unit Craters. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides, and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 375 dataset of investigation results was evaluated based on the data quality assessment. This assessment demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were assumed to be present within the default contamination boundaries at CASs 25-23-22 and 30-45-01. No contaminants were identified at CAS 25-34-06, and no corrective action is necessary. Potential source material in the form of lead plate, lead-acid batteries, and oil within an abandoned transformer were identified at CAS 30-45-01, and corrective actions were

30 CFR 57.22240 - Actions at 2.0 percent methane (V-A mines).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Actions at 2.0 percent methane (V-A mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22240 Actions at 2.0 percent methane (V-A mines). If methane reaches 2.0 percent in the mine atmosphere, all persons other than...

30 CFR 57.22233 - Actions at 0.5 percent methane (I-C mines).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Actions at 0.5 percent methane (I-C mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22233 Actions at 0.5 percent methane (I-C mines). If methane reaches 0.5 percent in the mine atmosphere, ventilation changes...

30 CFR 57.22240 - Actions at 2.0 percent methane (V-A mines).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Actions at 2.0 percent methane (V-A mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22240 Actions at 2.0 percent methane (V-A mines). If methane reaches 2.0 percent in the mine atmosphere, all persons other than...

30 CFR 57.22233 - Actions at 0.5 percent methane (I-C mines).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Actions at 0.5 percent methane (I-C mines). 57... MINES Safety Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22233 Actions at 0.5 percent methane (I-C mines). If methane reaches 0.5 percent in the mine atmosphere, ventilation changes...

PLAZA 3.0: an access point for plant comparative genomics

PubMed Central

Proost, Sebastian; Van Bel, Michiel; Vaneechoutte, Dries; Van de Peer, Yves; Inzé, Dirk; Mueller-Roeber, Bernd; Vandepoele, Klaas

2015-01-01

Comparative sequence analysis has significantly altered our view on the complexity of genome organization and gene functions in different kingdoms. PLAZA 3.0 is designed to make comparative genomics data for plants available through a user-friendly web interface. Structural and functional annotation, gene families, protein domains, phylogenetic trees and detailed information about genome organization can easily be queried and visualized. Compared with the first version released in 2009, which featured nine organisms, the number of integrated genomes is more than four times higher, and now covers 37 plant species. The new species provide a wider phylogenetic range as well as a more in-depth sampling of specific clades, and genomes of additional crop species are present. The functional annotation has been expanded and now comprises data from Gene Ontology, MapMan, UniProtKB/Swiss-Prot, PlnTFDB and PlantTFDB. Furthermore, we improved the algorithms to transfer functional annotation from well-characterized plant genomes to other species. The additional data and new features make PLAZA 3.0 (http://bioinformatics.psb.ugent.be/plaza/) a versatile and comprehensible resource for users wanting to explore genome information to study different aspects of plant biology, both in model and non-model organisms. PMID:25324309

Low temperature structural and transport studies of La{sub 0.175}Pr{sub 0.45}Ca{sub 0.375}MnO{sub 3-δ}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharma, Shivani; Shahee, Aga; Singh, Kiran

2016-05-23

The temperature (T) dependent x-ray diffraction (XRD) and resistivity measurements of La{sub 0.175}Pr{sub 0.45}Ca{sub 0.375}MnO{sub 3-δ} (LPCMO) have been performed down to 2 K to understand the structural and transport properties. From room temperature down to 220 K, LPCMO exists in orthorhombic phase with Pnma structure and at T~220 K, it transforms to charge ordered (CO) monoclinic phase with P2{sub 1}/m structure and remains as it is down to 2 K. The CO phase is evident from the occurrence of weak but well defined superlattice peaks in the XRD pattern. This structural transformation is of first order in nature asmore » evident from the phase coexistence across the transition region. These results thus clearly illustrate that LPCMO undergoes a first order structural phase transition from charge disordered orthorhombic phase to CO monoclinic phase at ~220 K, consistent with temperature dependent resistivity results. Our structural analysis of T dependent XRD data using Rietveld refinement infers that below 220 K, LPCMO forms commensurate CO monoclinic P2{sub 1}/m structure with four times structural modulation.« less

Liraglutide 3.0 mg for weight management: weight-loss dependent and independent effects.

PubMed

Bays, Harold; Pi-Sunyer, Xavier; Hemmingsson, Joanna Uddén; Claudius, Birgitte; Jensen, Christine B; Van Gaal, Luc

2017-02-01

As an adjunct to a reduced-calorie diet and increased physical activity, treatment with liraglutide 3.0 mg for weight management provides a statistically significant and clinically meaningful weight loss of 5.7%-8.0% compared to 1.6%-2.6% with placebo. The objective of this post hoc analysis was to quantify the relative contribution of weight loss to the treatment effects of liraglutide 3.0 mg on key efficacy endpoints. The analysis utilized data from 4725 participants across three randomized, placebo-controlled, double-blind trials that evaluated the efficacy and safety of liraglutide 3.0 mg versus placebo, as an adjunct to a reduced-calorie diet and increased physical activity (ClinicalTrials.gov identifiers: NCT01272219, NCT01272232 and NCT01557166). The duration of two of the trials was 56 weeks; one trial was of 32 weeks' duration. A mediation analysis was performed, which ranked the relative contribution of weight loss to the treatment effects of liraglutide 3.0 mg on key cardiometabolic efficacy endpoints, Apnea-Hypopnea Index (AHI) and health-related quality of life (QoL). A limitation of this type of analysis is that it cannot conclusively prove a causal relationship. In individuals without type 2 diabetes mellitus (T2DM), endpoints predominantly driven by liraglutide-induced weight loss included waist circumference, diastolic blood pressure, triglycerides, high density lipoprotein cholesterol, AHI, and Impact of Weight on Quality of Life-Lite total and physical function scores. Endpoints predominantly independent of weight loss included the glycemic endpoints hemoglobin A1c and fasting plasma glucose in individuals with and without T2DM. Regardless of the degree of dependence on weight loss according to the mediation analysis, greater weight loss was associated with greater improvement in all endpoints. Treatment with liraglutide 3.0 mg contributes to improved cardiometabolic parameters, AHI and health-related QoL through both weight

Evaluation of the VERSANT HCV RNA 3.0 assay for quantification of hepatitis C virus RNA in serum.

PubMed

Trimoulet, Pascale; Halfon, Philippe; Pohier, Eric; Khiri, Hacène; Chêne, Geneviève; Fleury, Hervé

2002-06-01

We assessed the performance of a new assay (VERSANT HCV RNA 3.0 [bDNA 3.0] assay [Bayer Diagnostics]) to quantitate HCV RNA levels and compared the results of the bDNA 3.0 assay to results of the Quantiplex HCV RNA 2.0 (bDNA 2.0) assay. Samples used in this study included 211 serum specimens from hepatitis C virus (HCV)-infected persons from two sites (Bordeaux and Marseille, France) with different genotypes; 383 serum specimens from HCV antibody-negative, HCV RNA-negative persons; and serial dilutions of World Health Organization (WHO) HCV RNA standard at a titer of 100,000 IU/ml. The specificity of the bDNA 3.0 assay was 98.2%. A high correlation was observed between expected and observed values in all dilutions of WHO standard (r = 0.9982), in serial dilutions of pooled samples (r = 0.9996), and in diluted sera from different HCV genotypes (r = 0.9930 to 0.9995). The standard deviations (SD) for the within-run and between-run reproducibility of the bDNA 3.0 assay were 0.2 and 0.14, respectively. The intersite SD ranged from 0.03 to 0.14. The bDNA 3.0 assay results were positively correlated with the bDNA 2.0 assay results (r = 0.9533). Taking in account the overall performance, this assay could be used as a routine tool for the HCV RNA quantification.

Evaluation of the VERSANT HCV RNA 3.0 Assay for Quantification of Hepatitis C Virus RNA in Serum

PubMed Central

Trimoulet, Pascale; Halfon, Philippe; Pohier, Eric; Khiri, Hacène; Chêne, Geneviève; Fleury, Hervé

2002-01-01

We assessed the performance of a new assay (VERSANT HCV RNA 3.0 [bDNA 3.0] assay [Bayer Diagnostics]) to quantitate HCV RNA levels and compared the results of the bDNA 3.0 assay to results of the Quantiplex HCV RNA 2.0 (bDNA 2.0) assay. Samples used in this study included 211 serum specimens from hepatitis C virus (HCV)-infected persons from two sites (Bordeaux and Marseille, France) with different genotypes; 383 serum specimens from HCV antibody-negative, HCV RNA-negative persons; and serial dilutions of World Health Organization (WHO) HCV RNA standard at a titer of 100,000 IU/ml. The specificity of the bDNA 3.0 assay was 98.2%. A high correlation was observed between expected and observed values in all dilutions of WHO standard (r = 0.9982), in serial dilutions of pooled samples (r = 0.9996), and in diluted sera from different HCV genotypes (r = 0.9930 to 0.9995). The standard deviations (SD) for the within-run and between-run reproducibility of the bDNA 3.0 assay were ≤0.2 and ≤0.14, respectively. The intersite SD ranged from 0.03 to 0.14. The bDNA 3.0 assay results were positively correlated with the bDNA 2.0 assay results (r = 0.9533). Taking in account the overall performance, this assay could be used as a routine tool for the HCV RNA quantification. PMID:12037059

Damage morphology study of high cycle fatigued as-cast Mg–3.0Nd–0.2Zn–Zr (wt.%) alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yue, Haiyan; Fu, Penghuai, E-mail: fph112sjtu@sjtu.edu.cn; Peng, Liming

Laser scanning confocal microscopy (LSCM) and Electron back-scattered diffraction (EBSD) were applied to the study of surface morphology variation of as-cast Mg–3.0Nd–0.2Zn–Zr (NZ30K) (wt.%) alloy under tension-compression fatigue test at room temperature. Two kinds of typical damage morphologies were observed in fatigued NZ30K alloy: One was parallel lines on basal planes led by the cumulation of basal slips, called persistent slip markings (PSMs), and the other was lens shaped, thicker and in less density, led by the formation of twinning. The surface fatigue damage morphology evolution was analyzed in a statistical way. The influences of stress amplitude and grain orientationmore » on fatigue deformation mechanisms were discussed and the non-uniform deformation among grains and the PSMs, within twinning were described quantitatively. - Highlights: • Fatigue morphology evolution was studied by Laser Scanning Confocal Microscopy. • 3D morphology of persistent slip markings and twins was characterized. • Non-uniform deformation among grains, the PSMs and twins were quantified. • Initiations of fatigue crack were clearly investigated.« less

Reliability and validity of the Chinese mandarin version of PedsQL™ 3.0 transplant module.

PubMed

Chang, Ying; Luo, Yanhui; Zhou, Yuchen; Wang, Ruixin; Song, Na; Zhu, Guanghua; Wang, Bin; Qin, Maoquan; Yang, Jun; Sun, Yuan; Li, Chunfu; Zhou, Xuan

2016-10-05

Long-term health-related quality of life (HRQoL) of pediatric patients after hematopoietic stem cell transplantation (HSCT) is increasingly studied worldwide. However, few studies have been performed in China, where no uniform scale is available; the PedsQL™ Cancer Module 3.0 Chinese Mandarin version has been used to evaluate HRQoL of patients after HSCT in China. This study aimed to assess the reliability and validity of the Chinese Mandarin version of PedsQL™ 3.0 Transplant Module. Patients between 2 and 18 years old, who underwent HSCT from January 2006 to June 2014, were recruited in Beijing Children's Hospital affiliated to Capital Medical University, the First Affiliated Hospital of Southern Medical University and Beijing Daopei Hospital. 207 parent reports and 182 child self-reports of the PedsQL™ 3.0 Transplant Module Chinese Mandarin version were assigned, of which 362 were returned. No missing item response was observed in the returned reports. Cronbach's alpha coefficient exceeded 0.7 in total scale and every dimension. The intraclass correlation coefficient exceeded 0.8 in all dimensions of child self-reports and parent reports. Spearman's rank correlation coefficients of items and their respective dimensions were 0.6-0.94 in parent reports, and 0.62-0.93 in child self-reports, while a weak association was found between the items and other dimensions. Exploratory factor analysis indicated a good extraction effect, and construct validity of the scale was >60 %. The Chinese Mandarin version of PedsQL™ 3.0 Transplant Module has good feasibility, reliability and validity. Its use may help improve the HRQoL of children after HSCT in China.

The U.S. Geological Survey coal quality (COALQUAL) database version 3.0

USGS Publications Warehouse

Palmer, Curtis A.; Oman, Charles L.; Park, Andy J.; Luppens, James A.

2015-12-21

Because of database size limits during the development of COALQUAL Version 1.3, many analyses of individual bench samples were merged into whole coal bed averages. The methodology for making these composite intervals was not consistent. Size limits also restricted the amount of georeferencing information and forced removal of qualifier notations such as "less than detection limit" (<) information, which can cause problems when using the data. A review of the original data sheets revealed that COALQUAL Version 2.0 was missing information that was needed for a complete understanding of a coal section. Another important database issue to resolve was the USGS "remnant moisture" problem. Prior to 1998, tests for remnant moisture (as-determined moisture in the sample at the time of analysis) were not performed on any USGS major, minor, or trace element coal analyses. Without the remnant moisture, it is impossible to convert the analyses to a usable basis (as-received, dry, etc.). Based on remnant moisture analyses of hundreds of samples of different ranks (and known residual moisture) reported after 1998, it was possible to develop a method to provide reasonable estimates of remnant moisture for older data to make it more useful in COALQUAL Version 3.0. In addition, COALQUAL Version 3.0 is improved by (1) adding qualifiers, including statistical programming to deal with the qualifiers; (2) clarifying the sample compositing problems; and (3) adding associated samples. Version 3.0 of COALQUAL also represents the first attempt to incorporate data verification by mathematically crosschecking certain analytical parameters. Finally, a new database system was designed and implemented to replace the outdated DOS program used in earlier versions of the database.

User's Guide to the Western Root Disease Model, Version 3.0

Treesearch

Susan J. Frankel

1998-01-01

Effects of Armillaria spp., Phellinus weirii, Heterobasidion annosum, or bark beetles on stand dynamics are represented by the Western Root Disease Model,Version 3.0. This model, which operates in conjunction with the Forest Vegetation Simulator, can be used to evaluate the effects of many silvicultural practices. This guide contains instructions for use, detailed...

The immune epitope database (IEDB) 3.0

PubMed Central

Vita, Randi; Overton, James A.; Greenbaum, Jason A.; Ponomarenko, Julia; Clark, Jason D.; Cantrell, Jason R.; Wheeler, Daniel K.; Gabbard, Joseph L.; Hix, Deborah; Sette, Alessandro; Peters, Bjoern

2015-01-01

The IEDB, www.iedb.org, contains information on immune epitopes—the molecular targets of adaptive immune responses—curated from the published literature and submitted by National Institutes of Health funded epitope discovery efforts. From 2004 to 2012 the IEDB curation of journal articles published since 1960 has caught up to the present day, with >95% of relevant published literature manually curated amounting to more than 15 000 journal articles and more than 704 000 experiments to date. The revised curation target since 2012 has been to make recent research findings quickly available in the IEDB and thereby ensure that it continues to be an up-to-date resource. Having gathered a comprehensive dataset in the IEDB, a complete redesign of the query and reporting interface has been performed in the IEDB 3.0 release to improve how end users can access this information in an intuitive and biologically accurate manner. We here present this most recent release of the IEDB and describe the user testing procedures as well as the use of external ontologies that have enabled it. PMID:25300482

Convective heat transfer studies at high temperatures with pressure gradient for inlet flow Mach number of 0.45

NASA Technical Reports Server (NTRS)

Pedrosa, A. C. F.; Nagamatsu, H. T.; Hinckel, J. A.

1984-01-01

Heat transfer measurements were determined for a flat plate with and without pressure gradient for various free stream temperatures, wall temperature ratios, and Reynolds numbers for an inlet flow Mach number of 0.45, which is a representative inlet Mach number for gas turbine rotor blades. A shock tube generated the high temperature and pressure air flow, and a variable geometry test section was used to produce inlet flow Mach number of 0.45 and accelerate the flow over the plate to sonic velocity. Thin-film platinum heat gages recorded the local heat flux for laminar, transition, and turbulent boundary layers. The free stream temperatures varied from 611 R (339 K) to 3840 R (2133 K) for a T(w)/T(r,g) temperature ratio of 0.87 to 0.14. The Reynolds number over the heat gages varied from 3000 to 690,000. The experimental heat transfer data were correlated with laminar and turbulent boundary layer theories for the range of temperatures and Reynolds numbers and the transition phenomenon was examined.

Paced Auditory Serial Addition Test (PASAT 3.0 s): Demographically corrected norms for the Portuguese population.

PubMed

Sousa, Claudia Sofia; Neves, Mariana Rigueiro; Passos, Ana Margarida; Ferreira, Aristides; Sá, Maria José

2017-05-23

The main goal of this study was to produce adjusted normative data for the Portuguese population on the Paced Auditory Serial Addition Test (PASAT 3.0 s), the version used in the Brief Repeatable Battery of Neuropsychological Tests developed by the National Multiple Sclerosis Society. The study included 326 community-dwelling individuals (199 women and 127 men) aged between 20 and 70 (mean = 40.33, SD = 14.40), who had educational backgrounds ranging from 4 to 23 years of schooling (mean = 12.28, SD = 4.39). Age, gender and qualifications revealed differences in explaining their performance on the PASAT 3.0 s. Men had significantly better performance on the PASAT 3.0 s than women, even though this represents a small effect size r = 0.18. Demographically corrected normative data was developed and important information regarding performance on the PASAT 3.0 s test is provided. Results are discussed and presented in tables and a formula is presented for computing age, gender and education adjusted T-scores for performance on the PASAT 3.0 s. These results should be considered as useful reference values for clinicians and investigators when applying the PASAT 3.0 s to assess cognitive function like information processing speed in different pathologies.

Validation of FIBER 3.0 for tolerant hardwood stands in Ontario

Treesearch

Jacek Bankowski; Daniel C. Dey; Murray Woods; Jim Rice; Eric Boysen; Brian Batchelor; Roj Miller

1995-01-01

Growth and yield projections aid foresters in assessing timber management opportunities and in making management decisions. With these uses, questions arise about the reliability and limits of growth and yield simulators. Using long-term studies of hardwood stands in Ontario the growth simulator FIBER 3.0 has been tested. Short-term (5 years) projections of stand...

Influence of Europium Doping on Various Electrical Properties of Low-Temperature Sintered 0.5Ba0.90Ca0.10TiO3-0.5BaTi0.88Zr0.12O3-0.1%CuO- xEu Lead-Free Ceramics

NASA Astrophysics Data System (ADS)

Tian, Yongshang; Li, Shuiyun; Sun, Shulin; Gong, Yansheng; Li, Tiantian; Yu, Yongshang; Jing, Qiangshan

2018-01-01

0.5Ba0.90Ca0.10TiO3-0.5BaTi0.88Zr0.12O3-0.1%CuO- xEu (BCT-BZT-Cu- xEu; x = 0-0.90%) lead-free ceramics were sintered at 1220°C with as-synthesized nanoparticles by a modified Pechini method. The structural characteristics and electrical properties of the ceramics that were influenced by varying europium-doping were investigated. All the ceramics featured high densification (relative density: ˜ 96%). X-ray powder diffraction results indicated the samples possessed pure orthorhombic phase. The maximum relative permittivity ( ɛ r, 10869) was found at x around 0.30%. Europium ions could dope on different substitution sites in the ABO3 lattice, which evidently influenced electrical properties with various volumes of oxygen vacancy. Moreover, the formation mechanisms of oxygen vacancy and defect electron complexes were stated. The piezoelectric properties were impacted by defect electron complexes, internal stress, ionic electronegativity, etc. The optimal electrical properties, i.e., d 33 = 384 pC/N, Q m = 92, and k p = 0.36, were detected at x = 0.45%.

Sintering characteristic and microwave dielectric properties of 0.45Ca0.6Nd0.267TiO3-0.55Li0.5Nd0.5TiO3 ceramics with La2O3-B2O3-ZnO additive

NASA Astrophysics Data System (ADS)

Chen, Yawei; Zhang, Shuren; Li, Enzhu; Niu, Na; Yang, Hongcheng

2018-02-01

The La2O3-B2O3-ZnO (LBZ) glass was proved to be an effective sintering aid of the 0.45Ca0.6Nd0.26TiO3-0.55Li0.5Nd0.5TiO3 (CNT-LNT) ceramics. The influence of LBZ glass on the phase composition, low temperature sintering process, microstructure, activation energy, and dielectric properties of CNT-LNT ceramics was investigated in detail. The LBZ glass induced an obvious decrease of the CNT-LNT ceramics sintering temperature from 1350 to 1000 °C due to the liquid phase formation, which reduced the activation energy ( E a) of the CNT-LNT ceramics. In addition, the near zero temperature coefficient of resonant frequency (τƒ) value was obtained by adding moderate quantity of LBZ glass. CNT-LNT + 5 wt% LBZ (CNT-LNT + 5L) ceramics sintered at 1000°C/4 h displayed good microwave dielectric properties of: ɛ r = 101.7, Q × f = 1560 GHz ( f = 3.25 GHz) and τ ƒ = 2.3 ppm °C-1.

A noise power spectrum study of a new model-based iterative reconstruction system: Veo 3.0.

PubMed

Li, Guang; Liu, Xinming; Dodge, Cristina T; Jensen, Corey T; Rong, X John

2016-09-08

The purpose of this study was to evaluate performance of the third generation of model-based iterative reconstruction (MBIR) system, Veo 3.0, based on noise power spectrum (NPS) analysis with various clinical presets over a wide range of clinically applicable dose levels. A CatPhan 600 surrounded by an oval, fat-equivalent ring to mimic patient size/shape was scanned 10 times at each of six dose levels on a GE HD 750 scanner. NPS analysis was performed on images reconstructed with various Veo 3.0 preset combinations for comparisons of those images reconstructed using Veo 2.0, filtered back projection (FBP) and adaptive statistical iterative reconstruc-tion (ASiR). The new Target Thickness setting resulted in higher noise in thicker axial images. The new Texture Enhancement function achieved a more isotropic noise behavior with less image artifacts. Veo 3.0 provides additional reconstruction options designed to allow the user choice of balance between spatial resolution and image noise, relative to Veo 2.0. Veo 3.0 provides more user selectable options and in general improved isotropic noise behavior in comparison to Veo 2.0. The overall noise reduction performance of both versions of MBIR was improved in comparison to FBP and ASiR, especially at low-dose levels. © 2016 The Authors.

Magnetic field simulation and shimming analysis of 3.0T superconducting MRI system

NASA Astrophysics Data System (ADS)

Yue, Z. K.; Liu, Z. Z.; Tang, G. S.; Zhang, X. C.; Duan, L. J.; Liu, W. C.

2018-04-01

3.0T superconducting magnetic resonance imaging (MRI) system has become the mainstream of modern clinical MRI system because of its high field intensity and high degree of uniformity and stability. It has broad prospects in scientific research and other fields. We analyze the principle of magnet designing in this paper. We also perform the magnetic field simulation and shimming analysis of the first 3.0T/850 superconducting MRI system in the world using the Ansoft Maxwell simulation software. We guide the production and optimization of the prototype based on the results of simulation analysis. Thus the magnetic field strength, magnetic field uniformity and magnetic field stability of the prototype is guided to achieve the expected target.

PLAZA 3.0: an access point for plant comparative genomics.

PubMed

Proost, Sebastian; Van Bel, Michiel; Vaneechoutte, Dries; Van de Peer, Yves; Inzé, Dirk; Mueller-Roeber, Bernd; Vandepoele, Klaas

2015-01-01

Comparative sequence analysis has significantly altered our view on the complexity of genome organization and gene functions in different kingdoms. PLAZA 3.0 is designed to make comparative genomics data for plants available through a user-friendly web interface. Structural and functional annotation, gene families, protein domains, phylogenetic trees and detailed information about genome organization can easily be queried and visualized. Compared with the first version released in 2009, which featured nine organisms, the number of integrated genomes is more than four times higher, and now covers 37 plant species. The new species provide a wider phylogenetic range as well as a more in-depth sampling of specific clades, and genomes of additional crop species are present. The functional annotation has been expanded and now comprises data from Gene Ontology, MapMan, UniProtKB/Swiss-Prot, PlnTFDB and PlantTFDB. Furthermore, we improved the algorithms to transfer functional annotation from well-characterized plant genomes to other species. The additional data and new features make PLAZA 3.0 (http://bioinformatics.psb.ugent.be/plaza/) a versatile and comprehensible resource for users wanting to explore genome information to study different aspects of plant biology, both in model and non-model organisms. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

National Survey of Sensory Features in Children with ASD: Factor Structure of the Sensory Experience Questionnaire (3.0)

ERIC Educational Resources Information Center

Ausderau, Karla; Sideris, John; Furlong, Melissa; Little, Lauren M.; Bulluck, John; Baranek, Grace T.

2014-01-01

This national online survey study characterized sensory features in 1,307 children with autism spectrum disorder (ASD) ages 2-12 years using the Sensory Experiences Questionnaire Version 3.0 (SEQ-3.0). Using the SEQ-3.0, a confirmatory factor analytic model with four substantive factors of hypothesized sensory response patterns (i.e.,…

Neutron scattering from 208Pb at 30.4 and 40.0 MeV and isospin dependence of the nucleon optical potential

NASA Astrophysics Data System (ADS)

Devito, R. P.; Khoa, Dao T.; Austin, Sam M.; Berg, U. E. P.; Loc, Bui Minh

2012-02-01

Background: Analysis of data involving nuclei far from stability often requires the optical potential (OP) for neutron scattering. Because neutron data are seldom available, whereas proton scattering data are more abundant, it is useful to have estimates of the difference of the neutron and proton optical potentials. This information is contained in the isospin dependence of the nucleon OP. Here we attempt to provide it for the nucleon-208Pb system.Purpose: The goal of this paper is to obtain accurate n+208Pb scattering data and use it, together with existing p+208Pb and 208Pb(p,n)208BiIAS* data, to obtain an accurate estimate of the isospin dependence of the nucleon OP at energies in the 30-60-MeV range.Method: Cross sections for n+208Pb scattering were measured at 30.4 and 40.0 MeV, with a typical relative (normalization) accuracy of 2-4% (3%). An angular range of 15∘ to 130∘ was covered using the beam-swinger time-of-flight system at Michigan State University. These data were analyzed by a consistent optical-model study of the neutron data and of elastic p+208Pb scattering at 45 and 54 MeV. These results were combined with a coupled-channel analysis of the 208Pb(p,n) reaction at 45 MeV, exciting the 0+ isobaric analog state (IAS) in 208Bi.Results: The new data and analysis give an accurate estimate of the isospin impurity of the nucleon-208Pb OP at 30.4 MeV caused by the Coulomb correction to the proton OP. The corrections to the real proton OP given by the CH89 global systematics were found to be only a few percent, whereas for the imaginary potential it was greater than 20% at the nuclear surface. On the basis of the analysis of the measured elastic n+208Pb data at 40 MeV, a Coulomb correction of similar strength and shape was also predicted for the p+208Pb OP at energies around 54 MeV.Conclusions: Accurate neutron scattering data can be used in combination with proton scattering data and (p,n) charge exchange data leading to the IAS to obtain reliable

Enamel Surface with Pit and Fissure Sealant Containing 45S5 Bioactive Glass.

PubMed

Yang, S-Y; Kwon, J-S; Kim, K-N; Kim, K-M

2016-05-01

Enamel demineralization adjacent to pit and fissure sealants leads to the formation of marginal caries, which can necessitate the replacement of existing sealants. Dental materials with bioactive glass, which releases ions that inhibit dental caries, have been studied. The purpose of this study was to evaluate the enamel surface adjacent to sealants containing 45S5 bioactive glass (BAG) under simulated microleakage between the material and the tooth in a cariogenic environment. Sealants containing 45S5BAG filler were prepared as follows: 0% 45S5BAG + 50.0% glass (BAG0 group), 12.5% 45S5BAG + 37.5% glass (BAG12.5 group), 25.0% 45S5BAG + 25.0% glass (BAG25.0 group), 37.5% 45S5BAG + 12.5% glass (BAG37.5 group), and 50.0% 45S5BAG + 0% glass (BAG50.0 group). A cured sealant disk was placed over a flat bovine enamel disk, separated by a 60-µm gap, and immersed in lactic acid solution (pH 4.0) at 37 °C for 15, 30, and 45 d. After the storage period, each enamel disk was separated from the cured sealant disk, and the enamel surface was examined with optical 3-dimensional surface profilometer, microhardness tester, and scanning electron microscopy. The results showed a significant increase in roughness and a decrease in microhardness of the enamel surface as the proportion of 45S5BAG decreased (P< 0.05). In the scanning electron microscopy images, enamel surfaces with BAG50.0 showed a smooth surface, similar to those in the control group with distilled water, even after prolonged acid storage. Additionally, an etched pattern was observed on the surface of the demineralized enamel with a decreasing proportion of 45S5BAG. Increasing the 45S5BAG filler contents of the sealants had a significant impact in preventing the demineralization of the enamel surface within microgaps between the material and the tooth when exposed to a cariogenic environment. Therefore, despite some marginal leakage, these novel sealants may be effective preventive dental materials for inhibiting

DGIdb 3.0: a redesign and expansion of the drug-gene interaction database.

PubMed

Cotto, Kelsy C; Wagner, Alex H; Feng, Yang-Yang; Kiwala, Susanna; Coffman, Adam C; Spies, Gregory; Wollam, Alex; Spies, Nicholas C; Griffith, Obi L; Griffith, Malachi

2018-01-04

The drug-gene interaction database (DGIdb, www.dgidb.org) consolidates, organizes and presents drug-gene interactions and gene druggability information from papers, databases and web resources. DGIdb normalizes content from 30 disparate sources and allows for user-friendly advanced browsing, searching and filtering for ease of access through an intuitive web user interface, application programming interface (API) and public cloud-based server image. DGIdb v3.0 represents a major update of the database. Nine of the previously included 24 sources were updated. Six new resources were added, bringing the total number of sources to 30. These updates and additions of sources have cumulatively resulted in 56 309 interaction claims. This has also substantially expanded the comprehensive catalogue of druggable genes and anti-neoplastic drug-gene interactions included in the DGIdb. Along with these content updates, v3.0 has received a major overhaul of its codebase, including an updated user interface, preset interaction search filters, consolidation of interaction information into interaction groups, greatly improved search response times and upgrading the underlying web application framework. In addition, the expanded API features new endpoints which allow users to extract more detailed information about queried drugs, genes and drug-gene interactions, including listings of PubMed IDs, interaction type and other interaction metadata.

Technology sensitivity studies for a Mach 3.0 civil transport

NASA Technical Reports Server (NTRS)

Coen, Peter G.

1988-01-01

The level of technological sophistication required for the economic viability and environmental acceptability of a Mach 3.0-cruise SST is evaluated, with a view to the development schedule and initial operating date into which the maturity of various essential technologies will translate. Attention is given to the effect of advanced aerodynamic, propulsion, structural and subsystem technologies on takeoff gross weight. A dramatic impact is noted to result from the combination of prospective technological advances in flow laminarization, advanced structures and materials, etc.

BPERM version 3.0: A 2-D wakepotential/impedance code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barts, T.; Chou, W.

1996-10-01

BPERM 3.0 is an improved version of a previous release. The main purpose of this version is to make it more user friendly. Following a simple 1-2-3 procedure, one obtains both text and graphical output of the wakepotential and impedance for a given geometry. The calculation is based on a boundary perturbation method, which is significantly faster than numerical simulations. It is accurate when the discontinuities are small. In particular, it works well for tapered structures. 5 refs., 3 figs.

NPARC v3.1 User's Guide: A Companion to the NPARC v3.0 User's Guide

NASA Technical Reports Server (NTRS)

Chung, Joongkee; Slater, John W.; Suresh, Ambady; Townsend, Scott

1999-01-01

NPARC v3.1 is a modification to the NPARC v3.0 computer program which expands the capabilities for time-accurate computations through the use of a Newton iterative implicit method, time-varying boundary conditions, and planar dynamic grids. This document discusses some of the changes from the NPARC v3.0, specifically: changes to the directory structure and execution, changes to the input format. background on new methods, new boundary conditions. dynamic grids, new options for output, usage concepts, and some test cases to serve as tutorials. This document is intended to be used in conjunction with the NPARC v3.0 user's guide.

Seedbed Density Affects Size of 3-0 Green Ash Nursery Stock

Treesearch

J.H. Stoeckeler

1967-01-01

Nursery seedbed density of 3-0 green ash, which ranged from 4 to 36 trees per square foot at Carlos Avery Nursery, Forest Lake, Minn., had a marked effect on caliper, height, fresh weight, and percent and amound of plantable stock. The highest number of good-quality trees was produced at a density of 12.5 trees per square foot.

A comparative evaluation between real time Roche COBas TAQMAN 48 HCV and bDNA Bayer Versant HCV 3.0.

PubMed

Giraldi, Cristina; Noto, Alessandra; Tenuta, Robert; Greco, Francesca; Perugini, Daniela; Spadafora, Mario; Bianco, Anna Maria Lo; Savino, Olga; Natale, Alfonso

2006-10-01

The HCV virus is a common human pathogen made of a single stranded RNA genome with 9600nt. This work compared two different commercial methods used for HCV viral load, the bDNA Bayer Versant HCV 3.0 and the RealTime Roche COBAS TaqMan 48 HCV. We compared the reproducibility and linearity of the two methods. Seventy-five plasma samples with genotypes 1 to 4, which represent the population (45% genotype 1; 24% genotype 2; 13% genotype 3; 18% genotype 4) were directly processed with the Versanto method based upon signal amplification; the same samples were first extracted (COBAS Ampliprep - TNAI) and then amplified using RealTime PCR (COBAS TaqMan 48). The results obtained indicate the same performance for both methods if they have genotype 1, but in samples with genotypes 2, 3 and 4 the RealTime PCR Roche method gave an underestimation in respect to the Bayer bDNA assay.

High-precision laser spectroscopy of the CO A(1)Π - X(1)Σ(+) (2,0), (3,0), and (4,0) bands.

PubMed

Niu, M L; Ramirez, F; Salumbides, E J; Ubachs, W

2015-01-28

High-precision two-photon Doppler-free frequency measurements have been performed on the CO A(1)Π - X(1)Σ(+) fourth-positive system (2,0), (3,0), and (4,0) bands. Absolute frequencies of forty-three transitions, for rotational quantum numbers up to J = 5, have been determined at an accuracy of 1.6 × 10(-3) cm(-1), using advanced techniques of two-color 2  +  1' resonance-enhanced multi-photon ionization, Sagnac interferometry, frequency-chirp analysis on the laser pulses, and correction for AC-Stark shifts. The accurate transition frequencies of the CO A(1)Π - X(1)Σ(+) system are of relevance for comparison with astronomical data in the search for possible drifts of fundamental constants in the early universe. The present accuracies in laboratory wavelengths of Δλ/λ = 2 × 10(-8) may be considered exact for the purpose of such comparisons.

Explicitly Accounting for Protected Lands within the GCAM 3.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dooley, James J.; Zhou, Yuyu

2012-05-01

The Global Change Assessment Model Version 3.0 defines three different levels of “Protected Lands” within the agricultural and landuse component. These three different scenarios effectively cordon off 3.5% (5.0 million km2) of the Earth’s terrestrial lands in the de minimus Protected Land Scenario, 5.0% (7.20 million km2) in the Core Protected Land Scenario, and 8.2% (11.8 million km2) in the Expanded Protected Land Scenario. None of these scenarios represents the “right” level of Protected Lands for the planet today or tomorrow. Rather, the goal is to create a range of scenarios that can be used in modeling human responses tomore » climate change and the impact those would have on managed and unmanaged terrestrial lands. These scenarios harness the wealth of information in the United Nations Environment Programme World Conservation Monitoring Centre’s World Database on Protected Areas and its categories of explicit degrees of protection.« less

Volumetric and acoustical behaviour of sodium saccharin in aqueous system over temperature range (20.0-45.0)°C.

PubMed

Jamal, Muhammad Asghar; Rashad, Muhammad; Khosa, Muhammad Kaleem; Bhatti, Haq Nawaz

2015-04-15

Densities and ultrasonic velocity values for aqueous solutions of sodium saccharin (SS) has been measured as a function of concentration at 20.0-45.0 °C and atmospheric pressure using DSA-5000 M. The density and ultrasonic velocity values have been further used to calculate apparent molar volume, apparent specific volume, isentropic apparent molar compressibility and compressibility hydration numbers and reported. The values for apparent molar volume obtained at given temperatures showed negative deviations from Debye-Hückel limiting law and used as a direct measure of the ion-ion and ion-solvent interactions. The apparent specific volumes of the solute were calculated and it was found that these values of the investigated solutions lie on the borderline between the values reported for sweet substances. The sweetness response of the sweeteners is then explained in terms of their solution behaviours. Furthermore, the partial molar expansibility, its second derivative, (∂(2)V°/∂T(2)) as Hepler's constant and thermal expansion coefficient have been estimated. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience.

PubMed

Russell, James A; Lee, Terry; Singer, Joel; Boyd, John H; Walley, Keith R

2017-06-01

The Septic Shock 3.0 definition could alter treatment comparisons in randomized controlled trials in septic shock. Our first hypothesis was that the vasopressin versus norepinephrine comparison and 28-day mortality of patients with Septic Shock 3.0 definition (lactate > 2 mmol/L) differ from vasopressin versus norepinephrine and mortality in Vasopressin and Septic Shock Trial. Our second hypothesis was that there are differences in plasma cytokine levels in Vasopressin and Septic Shock Trial for lactate less than or equal to 2 versus greater than 2 mmol/L. Retrospective analysis of randomized controlled trial. Multicenter ICUs. We compared vasopressin-to-norepinephrine group 28- and 90-day mortality in Vasopressin and Septic Shock Trial in lactate subgroups. We measured 39 cytokines to compare patients with lactate less than or equal to 2 versus greater than 2 mmol/L. Patients with septic shock with lactate greater than 2 mmol/L or less than or equal to 2 mmol/L, randomized to vasopressin or norepinephrine. Concealed vasopressin (0.03 U/min.) or norepinephrine infusions. The Septic Shock 3.0 definition would have decreased sample size by about half. The 28- and 90-day mortality rates were 10-12 % higher than the original Vasopressin and Septic Shock Trial mortality. There was a significantly (p = 0.028) lower mortality with vasopressin versus norepinephrine in lactate less than or equal to 2 mmol/L but no difference between treatment groups in lactate greater than 2 mmol/L. Nearly all cytokine levels were significantly higher in patients with lactate greater than 2 versus less than or equal to 2 mmol/L. The Septic Shock 3.0 definition decreased sample size by half and increased 28-day mortality rates by about 10%. Vasopressin lowered mortality versus norepinephrine if lactate was less than or equal to 2 mmol/L. Patients had higher plasma cytokines in lactate greater than 2 versus less than or equal to 2 mmol/L, a brisker cytokine response to infection. The Septic

Enhancement pattern of the normal facial nerve at 3.0 T temporal MRI.

PubMed

Hong, H S; Yi, B-H; Cha, J-G; Park, S-J; Kim, D H; Lee, H K; Lee, J-D

2010-02-01

The purpose of this study was to evaluate the enhancement pattern of the normal facial nerve at 3.0 T temporal MRI. We reviewed the medical records of 20 patients and evaluated 40 clinically normal facial nerves demonstrated by 3.0 T temporal MRI. The grade of enhancement of the facial nerve was visually scaled from 0 to 3. The patients comprised 11 men and 9 women, and the mean age was 39.7 years. The reasons for the MRI were sudden hearing loss (11 patients), Méniàre's disease (6) and tinnitus (7). Temporal MR scans were obtained by fluid-attenuated inversion-recovery (FLAIR) and diffusion-weighted imaging of the brain; three-dimensional (3D) fast imaging employing steady-state acquisition (FIESTA) images of the temporal bone with a 0.77 mm thickness, and pre-contrast and contrast-enhanced 3D spoiled gradient record acquisition in the steady state (SPGR) of the temporal bone with a 1 mm thickness, were obtained with 3.0 T MR scanning. 40 nerves (100%) were visibly enhanced along at least one segment of the facial nerve. The enhanced segments included the geniculate ganglion (77.5%), tympanic segment (37.5%) and mastoid segment (100%). Even the facial nerve in the internal auditory canal (15%) and labyrinthine segments (5%) showed mild enhancement. The use of high-resolution, high signal-to-noise ratio (with 3 T MRI), thin-section contrast-enhanced 3D SPGR sequences showed enhancement of the normal facial nerve along the whole course of the nerve; however, only mild enhancement was observed in areas associated with acute neuritis, namely the canalicular and labyrinthine segment.

Relieved kink effects in symmetrically graded In0.45Al0.55As/InxGa1-xAs metamorphic high-electron-mobility transistors

NASA Astrophysics Data System (ADS)

Lee, Ching-Sung; Liao, Chen-Hsian

2007-12-01

Kink effects in an In-rich InxGa1-xAs (x=0.53-0.63) linearly graded channel of an In0.45Al0.55As/InxGa1-xAs metamorphic high-electron-mobility transistor have been effectively relieved by depositing a high-barrier Ni /Au gate with the silicon nitride passivation. Complete physical investigations for the relieved kink effects have been made by comparing identical devices with/without a high-barrier Schottky gate or the surface passivation. After successfully suppressing the kink effects, the proposed device has shown a superior voltage gain of 173.8, low output conductance of 2.09mS/mm, and excellent power-added efficiency of 54.1% with high output power (power gain) of 14.87dBm (14.53dB). Improved linearity and excellent thermal threshold coefficient (∂Vth/∂T) of -0.14mV/K have also been achieved. The proposed design provides good potential for high-gain and high-linearity circuit applications.

Quantitative Mapping of Human Cartilage at 3.0T

PubMed Central

Wang, Ligong; Regatte, Ravinder R.

2014-01-01

Rationale and Objectives The objectives of this study were to measure the parallel changes of transverse relaxation times (T2), spin-lattice relaxation time in the rotating frame (T1ρ), and the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC)-T1 mapping of human knee cartilage in detecting cartilage degeneration at 3.0T. Materials and Methods Healthy volunteers (n = 10, mean age 35.6 years) and patients (n = 10, mean age 65 years) with early knee osteoarthritis (OA) were scanned at 3.0T MR using an 8-channel phased array knee coil (transmit–receive). Quantitative assessment of T2, T1ρ, and dGEMRIC-T1 values (global and regional) were correlated between asymptomatic subjects and patients with OA. Results The average T2 (39 ± 2 milliseconds [mean ± standard deviation] vs. 47 ± 6 milliseconds, P < .0007) and T1ρ (48 ± 3 vs. 62 ± 8 milliseconds, P < .0002) values were all markedly increased in all patients with OA when compared to healthy volunteers. The average dGEMRIC-T1 (1244 ± 134 vs. 643 ± 227 milliseconds, P < .000002) value was sharply decreased after intravenous administration of gadolinium contrast agent in all patients with OA. Conclusions The research results showed that all the T2, T1ρ, and dGEMRIC-T1 relaxation times varied with the cartilage degeneration. The dGEMRIC-T1 and T1ρ relaxation times seem to be more sensitive than T2 in detecting early cartilage degeneration. The preliminary study demonstrated that the early biochemical changes in knee osteoarthritic patients could be detected noninvasively in in vivo using T1ρ and dGEMRIC-T1 mapping. PMID:24594416

Kidney ischemia and reperfunsion syndrome: effect of lidocaine and local postconditioning.

PubMed

Yamaki, Igor Nagai; Pontes, Ruy Victor Simões; Costa, Felipe Lobato DA Silva; Yamaki, Vitor Nagai; Teixeira, Renan Kleber Costa; Yasojima, Edson Yuzur; Brito, Marcus Vinicius Henriques

2016-01-01

to evaluate the effects of blocking the regulation of vascular tone on the ischemia and reperfusion syndrome in rats through the use of lidocaine in the postconditioning technique. we randomized 35 rats into seven groups of five animals: Group 1- Control; Group 2- Ischemia and Reperfusion; Group 3- Ischemia, Reperfusion and Saline; Group 4- Ischemic Postconditioning; Group 5- Ischemic Postconditioning and Saline; Group 6- Lidocaine; Group 7- Ischemic Postconditioning and Lidocaine. Except for the control group, all the others were submitted to renal ischemia for 30 minutes. In postconditioning groups, we performed ischemia and reperfusion cycles of five minutes each, applied right after the main ischemia. In saline and lidocaine groups, we instilled the substances at a rate of two drops per minute. To compare the groups, we measured serum levels of urea and creatinine and also held renal histopathology. The postconditioning and postconditioning + lidocaine groups showed a decrease in urea and creatinine values. The lidocaine group showed only a reduction in creatinine values. In histopathology, only the groups submitted to ischemic postconditioning had decreased degree of tubular necrosis. Lidocaine did not block the effects of postconditioning on renal ischemia reperfusion syndrome, and conferred better glomerular protection when applied in conjunction with ischemic postconditioning. avaliar os efeitos do bloqueio da regulação do tônus vascular por meio do uso da lidocaína na técnica de pós-condicionamento isquêmico na síndrome de isquemia e reperfusão renal em ratos. trinta e cinco ratos foram randomizados em sete grupos de cinco animais: Grupo 1- Controle; Grupo 2- Isquemia e Reperfusão; Grupo 3- Isquemia, Reperfusão e Solução Salina; Grupo 4- Pós-condicionamento Isquêmico; Grupo 5- Pós-condicionamento Isquêmico e Solução Salina; Grupo 6- Lidocaína; Grupo 7- Pós-condicionamento Isquêmico e lidocaína. Com exceção do grupo controle, todos

45 CFR 305.0 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

...), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES PROGRAM PERFORMANCE MEASURES, STANDARDS, FINANCIAL INCENTIVES, AND PENALTIES § 305.0 Scope. This part implements the incentive system...

A pictorial presentation of 3.0 Chicago Classification for esophageal motility disorders.

PubMed

Herbella, Fernando Augusto; Armijo, Priscila Rodrigues; Patti, Marco Giuseppe

2016-01-01

High resolution manometry changed several esophageal motility paradigms. The 3.0 Chicago Classification defined manometric criteria for named esophageal motility disorders. We present a pictorial atlas of motility disorders. Achalasia types, esophagogastric junction obstruction, absent contractility, distal esophageal spasm, hypercontractile esophagus (jackhammer), ineffective esophageal motility, and fragmented peristalsis are depicted with high-resolution manometry plots. RESUMO A manometria de alta resolução mudou vários paradigmas da motilidade digestiva. A Classificação de Chicago, na versão 3.0, definiu critérios manométricos para as doenças da motilidade esofagiana. O presente artigo é um atlas das dismotilidades descritas. Tipos de acalásia, obstrução ao nível da junção esofagogástrica, contrações ausentes, espasmo esofagiano distal, esôfago hipercontrátil, motilidade esofagiana ineficaz e peristalse fragmentada são mostradas em traçados de manometria de alta resolução.

The Next G Web: Discernment, Meaning-Making, and the Implications of Web 3.0 for Education

ERIC Educational Resources Information Center

Poore, Megan

2014-01-01

What might Web 3.0 mean for education--that is, education seen as an intellectual and philosophical endeavour where we seek to critique the world and understand our place in it with others? In this paper, I argue that current emphases on the semantic functionality of Web 3.0 have the potential to concomitantly challenge and extend the humanist…

NASGRO 3.0: A Software for Analyzing Aging Aircraft

NASA Technical Reports Server (NTRS)

Mettu, S. R.; Shivakumar, V.; Beek, J. M.; Yeh, F.; Williams, L. C.; Forman, R. G.; McMahon, J. J.; Newman, J. C., Jr.

1999-01-01

Structural integrity analysis of aging aircraft is a critical necessity in view of the increasing numbers of such aircraft in general aviation, the airlines and the military. Efforts are in progress by NASA, the FAA and the DoD to focus attention on aging aircraft safety. The present paper describes the NASGRO software which is well-suited for effectively analyzing the behavior of defects that may be found in aging aircraft. The newly revised Version 3.0 has many features specifically implemented to suit the needs of the aircraft community. The fatigue crack growth computer program NASA/FLAGRO 2.0 was originally developed to analyze space hardware such as the Space Shuttle, the International Space Station and the associated payloads. Due to popular demand, the software was enhanced to suit the needs of the aircraft industry. Major improvements in Version 3.0 are the incorporation of the ability to read aircraft spectra of unlimited size, generation of common aircraft fatigue load blocks, and the incorporation of crack-growth models which include load-interaction effects such as retardation due to overloads and acceleration due to underloads. Five new crack-growth models, viz., generalized Willenborg, modified generalized Willenborg, constant closure model, Walker-Chang model and the deKoning-Newman strip-yield model, have been implemented. To facilitate easier input of geometry, material properties and load spectra, a Windows-style graphical user interface has been developed. Features to quickly change the input and rerun the problem as well as examine the output are incorporated. NASGRO has been organized into three modules, the crack-growth module being the primary one. The other two modules are the boundary element module and the material properties module. The boundary-element module provides the ability to model and analyze complex two-dimensional problems to obtain stresses and stress-intensity factors. The material properties module allows users to store and

MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience.

PubMed

Yoshimitsu, Kengo; Mitsufuji, Toshimichi; Shinagawa, Yoshinobu; Fujimitsu, Ritsuko; Morita, Ayako; Urakawa, Hiroshi; Hayashi, Hiroyuki; Takano, Koichi

2016-03-01

To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of liver fibrosis using preliminary clinical data. Between November 2012 and March 2014, MRE was applied to all patients who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation of liver tissue within 3 months from MR examinations were retrospectively recruited, and the liver stiffness measured by MRE was correlated with histological results. Institutional review board approved this study, waiving informed consent. There were 70 patients who met the inclusion criteria. Liver stiffness showed significant correlation with the pathological grades of liver fibrosis (rho = 0.89, p < 0.0001, Spearman's rank correlation). Areas under the receiver operating characteristic curve were 0.93, 0.95, 0.99 and 0.95 for fibrosis score greater than or equal to F1, F2, F3 and F4, with cut-off values of 3.13, 3.85, 4.28 and 5.38 kPa, respectively. Multivariate analysis suggested that grades of necroinflammation also affected liver stiffness, but to a significantly lesser degree as compared to fibrosis. 3.0-T clinical MRE was suggested to be sufficiently useful in assessing the grades of liver fibrosis. MR elastography may help clinicians assess patients with chronic liver diseases. Usefulness of 3.0-T MR elastography has rarely been reported. Measured liver stiffness correlated well with the histological grades of liver fibrosis. Measured liver stiffness was also affected by necroinflammation, but to a lesser degree. 3.0-T MRE could be a non-invasive alternative to liver biopsy.

Improvements in health-related quality of life with liraglutide 3.0 mg compared with placebo in weight management.

PubMed

Kolotkin, R L; Fujioka, K; Wolden, M L; Brett, J H; Bjorner, J B

2016-08-01

Obesity has a negative impact on health-related quality of life (HRQoL). The SCALE Obesity and Prediabetes study investigated the effect of liraglutide 3.0 mg, as adjunct to diet and exercise, on HRQoL in patients with obesity [body mass index (BMI) ≥ 30 kg m(-2) ] or overweight (BMI ≥ 27 kg m(-2) ) with comorbidity. Participants were advised on a 500 kcal d(-1) deficit diet and a 150-min week(-1) exercise programme and were randomised 2:1 to once-daily subcutaneous liraglutide 3.0 mg or placebo. HRQoL was assessed using the Impact of Weight on Quality of Life-Lite (IWQOL-Lite) and Short-Form 36 (SF-36) v2 health questionnaires. Individuals on liraglutide 3.0 mg (n = 2046) had significantly greater improvements in IWQOL-Lite total score (10.6 ± 13.3) vs. placebo (n = 1020) (7.7 ± 12.8) and SF-36 physical (PCS) and mental (MCS) component summary scores (PCS, 3.6 ± 6.8; MCS, 0.2 ± 8.1) vs. placebo (PCS, 2.2 ± 7.7; MCS, -0.9 ± 9.1). The estimated treatment differences were IWQOL-Lite total score 3.1 (95% CI: 2.2; 4.0), P < 0.0001; SF-36 PCS 1.7 (95% CI: 1.2; 2.2), P < 0.0001 and MCS 0.9 (95% CI: 0.3; 1.5), P = 0.003. All subscales of the IWQOL-Lite and SF-36 were significantly improved with liraglutide 3.0 mg vs. placebo. More patients on liraglutide 3.0 mg experienced meaningful improvement on the IWQOL-Lite total (P < 0.0001) and the SF-36 PCS (P < 0.0001) scores. © 2016 The Authors. Clinical Obesity published by John Wiley & Sons Ltd on behalf of International Association for the Study of Obesity (IASO).

Pulmonary tolerance in man to continuous oxygen exposure at 3.0, 2.5, 2.0, and 1.5 ATA in Predictive Studies V

NASA Technical Reports Server (NTRS)

Clark, J. M.; Gelfand, R.; Flores, N. D.; Lambertsen, C. J.; Pisarello, J. B.

1987-01-01

Oxygen effects on pulmonary function were measured in normal, resting men who breathed oxygen continuously at 3.0, 2.5, 2.0, and 1.5 ATA to predefined limits of CNS, cardiac, or pulmonary tolerance. Rates of pulmonary symptom intensification and decrease in vital capacity (VC) increased progressively with elevation of inspired oxygen pressure. Although VC decrements occurred concurrently with symptoms, the lung volume changes became prominent when symptoms were still mild. The observed effects were consistent with the interpretation that small airway function is impaired more selectively by oxygen exposure at 3.0 and 2.5 ATA than by exposure at 2.0 and 1.5 ATA. Despite similar VC changes after oxygen exposure at 2.0 ATA for nearly 10 hr and exposure at 1.5 ATA for almost 18 hr, the 2.0 ATA exposure caused greater impairment of pulmonary function and required a longer recovery period.

Variable impact of CSF flow suppression on quantitative 3.0T intracranial vessel wall measurements.

PubMed

Cogswell, Petrice M; Siero, Jeroen C W; Lants, Sarah K; Waddle, Spencer; Davis, L Taylor; Gilbert, Guillaume; Hendrikse, Jeroen; Donahue, Manus J

2018-03-31

Flow suppression techniques have been developed for intracranial (IC) vessel wall imaging (VWI) and optimized using simulations; however, simulation results may not translate in vivo. To evaluate experimentally how IC vessel wall and lumen measurements change in identical subjects when evaluated using the most commonly available blood and cerebrospinal fluid (CSF) flow suppression modules and VWI sequences. Prospective. Healthy adults (n = 13; age = 37 ± 15 years) were enrolled. A 3.0T 3D T 1 /proton density (PD)-weighted turbo-spin-echo (TSE) acquisition with post-readout anti-driven equilibrium module, with and without Delay-Alternating-with-Nutation-for-Tailored-Excitation (DANTE) was applied. DANTE flip angle (8-12°) and TSE refocusing angle (sweep = 40-120° or 50-120°) were varied. Basilar artery and internal carotid artery (ICA) wall thicknesses, CSF signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and signal ratio (SR) were assessed. Measurements were made by two readers (radiology resident and board-certified neuroradiologist). A Wilcoxon signed-rank test was applied with corrected two-sided P < 0.05 required for significance (critical P = 0.008, 0.005, and 0.05 for SNR/CNR, SR, and wall thickness, respectively). A TSE pulse sweep = 40-120° and sweep = 50-120° provided similar (P = 0.55) CSF suppression. Addition of the DANTE preparation reduced CSF SNR from 17.4 to 6.7, thereby providing significant (P < 0.008) improvement in CSF suppression. The DANTE preparation also resulted in a significant (P < 0.008) reduction in vessel wall SNR, but variable vessel wall to CSF CNR improvement (P = 0.87). There was a trend for a difference in blood SNR with vs. without DANTE (P = 0.05). The outer vessel wall diameter and wall thickness values were lower (P < 0.05) with (basilar artery 4.45 mm, 0.81 mm, respectively) vs. without (basilar artery 4.88 mm, 0.97 mm, respectively) DANTE 8�

Detailing magnetic field strength dependence and segmental artifact distribution of myocardial effective transverse relaxation rate at 1.5, 3.0, and 7.0 T.

PubMed

Meloni, Antonella; Hezel, Fabian; Positano, Vincenzo; Keilberg, Petra; Pepe, Alessia; Lombardi, Massimo; Niendorf, Thoralf

2014-06-01

Realizing the challenges and opportunities of effective transverse relaxation rate (R2 *) mapping at high and ultrahigh fields, this work examines magnetic field strength (B0 ) dependence and segmental artifact distribution of myocardial R2 * at 1.5, 3.0, and 7.0 T. Healthy subjects were considered. Three short-axis views of the left ventricle were examined. R2 * was calculated for 16 standard myocardial segments. Global and mid-septum R2 * were determined. For each segment, an artifactual factor was estimated as the deviation of segmental from global R2 * value. The global artifactual factor was significantly enlarged at 7.0 T versus 1.5 T (P = 0.010) but not versus 3.0 T. At 7.0 T, the most severe susceptibility artifacts were detected in the inferior lateral wall. The mid-septum showed minor artifactual factors at 7.0 T, similar to those at 1.5 and 3.0 T. Mean R2 * increased linearly with the field strength, with larger changes for global heart R2 * values. At 7.0 T, segmental heart R2 * analysis is challenging due to macroscopic susceptibility artifacts induced by the heart-lung interface and the posterior vein. Myocardial R2 * depends linearly on the magnetic field strength. The increased R2 * sensitivity at 7.0 T might offer means for susceptibility-weighted and oxygenation level-dependent MR imaging of the myocardium. Copyright © 2013 Wiley Periodicals, Inc.

Effect of temperature-driven phase transition on energy-storage and -release properties of Pb0.97La0.02[Zr0.55Sn0.30Ti0.15]O3 ceramics

NASA Astrophysics Data System (ADS)

Xu, Ran; Tian, Jingjing; Zhu, Qingshan; Feng, Yujun; Wei, Xiaoyong; Xu, Zhuo

2017-07-01

Temperature-driven phase transition of Pb0.97La0.02[Zr0.55Sn0.30Ti0.15]O3 ceramics was studied, and the consecutive ferroelectric-antiferroelectric-paraelectric (FE-AFE-PE) switching was confirmed. The materials have better dielectric tunability (-82% to 50%) in the AFE state than in the FE state. Also, the phase transition influences the energy-storage and -release performance significantly. A sharp increase in releasable energy density and efficiency was observed due to the temperature-driven FE-AFE transition. Highest releasable energy density, current density, and peak power density were achieved at 130 °C, which was attributed to the highest backward transition field. The stored charge was released completely in AFE and PE states in the microseconds scale, while only a small part of it was released in the FE state. The above results indicate the huge impact of temperature-driven phase transition on dielectrics' performance, which is significant when developing AFE materials working in a wide temperature range.

Value of 3.0 T MR imaging in refractory partial epilepsy and negative 1.5 T MRI.

PubMed

Nguyen, Dang Khoa; Rochette, Emilie; Leroux, Jean-Maxime; Beaudoin, Gilles; Cossette, Patrick; Lassonde, Maryse; Guilbert, François

2010-10-01

High-field 3.0 T MR scanners provide an improved signal-to-noise ratio which can be translated in higher image resolution, possibly allowing critical detection of subtle epileptogenic lesions missed on standard-field 1.0-1.5 T MRIs. In this study, the authors explore the potential value of re-imaging at 3.0 T patients with refractory partial epilepsy and negative 1.5 T MRI. We retrospectively identified all patients with refractory partial epilepsy candidate for surgery who had undergone a 3.0 T MR study after a negative 1.5 T MR study. High-field 3.0 T MRIs were reviewed qualitatively by neuroradiologists experienced in interpreting epilepsy studies with access to clinical information. Relevance and impact on clinical management were assessed by an epileptologist. Between November 2006 and August 2009, 36 patients with refractory partial epilepsy candidate for surgery underwent 3.0 T MR study after a 1.5 T MR study failed to disclose a relevant epileptogenic lesion. A potential lesion was found only in two patients (5.6%, 95% CI: 1.5-18.1%). Both were found to have hippocampal atrophy congruent with other presurgical localization techniques which resulted in omission of an invasive EEG study and direct passage to surgery. The frequency of detection of a new lesion by re-imaging at 3.0 T patients with refractory partial epilepsy candidate for surgery was found to be low, but seems to offer the potential of a significant clinical impact for selected patients. This finding needs to be validated in a prospective controlled study. Copyright © 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

A noise power spectrum study of a new model‐based iterative reconstruction system: Veo 3.0

PubMed Central

Li, Guang; Liu, Xinming; Dodge, Cristina T.; Jensen, Corey T.

2016-01-01

The purpose of this study was to evaluate performance of the third generation of model‐based iterative reconstruction (MBIR) system, Veo 3.0, based on noise power spectrum (NPS) analysis with various clinical presets over a wide range of clinically applicable dose levels. A CatPhan 600 surrounded by an oval, fat‐equivalent ring to mimic patient size/shape was scanned 10 times at each of six dose levels on a GE HD 750 scanner. NPS analysis was performed on images reconstructed with various Veo 3.0 preset combinations for comparisons of those images reconstructed using Veo 2.0, filtered back projection (FBP) and adaptive statistical iterative reconstruction (ASiR). The new Target Thickness setting resulted in higher noise in thicker axial images. The new Texture Enhancement function achieved a more isotropic noise behavior with less image artifacts. Veo 3.0 provides additional reconstruction options designed to allow the user choice of balance between spatial resolution and image noise, relative to Veo 2.0. Veo 3.0 provides more user selectable options and in general improved isotropic noise behavior in comparison to Veo 2.0. The overall noise reduction performance of both versions of MBIR was improved in comparison to FBP and ASiR, especially at low‐dose levels. PACS number(s): 87.57.‐s, 87.57.Q‐, 87.57.C‐, 87.57.nf, 87.57.C‐, 87.57.cm PMID:27685118

Pancreatic Duct in Autoimmune Pancreatitis: Intraindividual Comparison of Magnetic Resonance Pancreatography at 1.5 T and 3.0 T.

PubMed

Kim, Jin Hee; Byun, Jae Ho; Kim, Myung-Hwan; Lee, Sung Koo; Kim, Song Cheol; Kim, Hyoung Jung; Lee, Seung Soo; Kim, So Yeon; Lee, Moon-Gyu

2017-08-01

The aim of this study was to intraindividually compare magnetic resonance pancreatography (MRP) image quality at 1.5 T and 3.0 T when demonstrating main pancreatic duct (MPD) abnormalities in patients with autoimmune pancreatitis (AIP). Thirty prospectively enrolled patients with AIP underwent MRP at both 1.5 T and 3.0 T followed by endoscopic retrograde pancreatography before treatment. Two readers independently analyzed the MRP images and graded the visualization of MPD strictures and full-length MPD, using endoscopic retrograde pancreatography as the reference standard, as well as overall image artifacts on a 4-point scale. The contrast between the MPD and periductal area was calculated using a region-of-interest measurement. Visualization scores of MPD strictures and full-length MPD, and summed scores of each qualitative analysis, were significantly greater at 3.0-T MRP than at 1.5-T MRP for both readers (P ≤ 0.02). There were less image artifacts at 3.0 T compared with 1.5 T (P ≤ 0.052). The contrast between the MPD and periductal area was significantly greater at 3.0-T MRP than at 1.5-T MRP (P < 0.001). The MRP at 3.0 T was superior to 1.5-T MRP for demonstrating MPD abnormalities in AIP, with better image contrast and fewer image artifacts. Consequently, 3.0-T MRP may be useful for the diagnosis and management of patients with AIP.

Estimating Uncertainties of Ship Course and Speed in Early Navigations using ICOADS3.0

NASA Astrophysics Data System (ADS)

Chan, D.; Huybers, P. J.

2017-12-01

Information on ship position and its uncertainty is potentially important for mapping out climatologists and changes in SSTs. Using the 2-hourly ship reports from the International Comprehensive Ocean Atmosphere Dataset 3.0 (ICOADS 3.0), we estimate the uncertainties of ship course, ship speed, and latitude/longitude corrections during 1870-1900. After reviewing the techniques used in early navigations, we build forward navigation model that uses dead reckoning technique, celestial latitude corrections, and chronometer longitude corrections. The modeled ship tracks exhibit jumps in longitude and latitude, when a position correction is applied. These jumps are also seen in ICOADS3.0 observations. In this model, position error at the end of each day increases following a 2D random walk; the latitudinal/longitude errors are reset when a latitude/longitude correction is applied.We fit the variance of the magnitude of latitude/longitude corrections in the observation against model outputs, and estimate that the standard deviation of uncertainty is 5.5 degree for ship course, 32% for ship speed, 22km for latitude correction, and 27km for longitude correction. The estimates here are informative priors for Bayesian methods that quantify position errors of individual tracks.

Herschel and IRAM-30m Observations of Comet C/2012 S1 (ISON) at 4.5 AU from the Sun

NASA Astrophysics Data System (ADS)

O'Rourke, Laurence; Bockelée-Morvan, Dominique; Biver, Nicolas; Altieri, Bruno; Teyssier, David; Jorda, Laurent; Debout, Vincent; Snodgrass, Colin; Küppers, Michael; A'Hearn, Michael; Müller, Thomas; Farnham, Anthony

2015-04-01

The sungrazer comet C/2012 S1 (ISON) (perihelion at rh = 0.0125 AU from the Sun) was bright and active when discovered in September 2012 at 6.3 AU from the Sun. Our goal was to characterize the distant gaseous and dust activity of this comet, inbound, from observations of H2O, CO and the dust coma in the far-infrared and submillimeter domains. We report observations undertaken with the Herschel Space Observatory (Pilbratt et al, 2010) on 8 & 13 March 2013 (rh = 4.54--4.47AU) and with the 30m telescope of Institut de Radioastronomie Millimétrique (IRAM) in March and April 2013 (rh = 4.45--4.18 AU). The HIFI instrument aboard Herschel was used to observe the H2O 110-101 line at 557 GHz, whereas images of the dust coma at 70~μm and 160~μm were acquired with the PACS instrument. Spectra acquired at the IRAM 30m telescope cover the CO J(2--1) line at 230.5 GHz. The spectral observations were analysed with excitation and radiative transfer models (Biver et al., 2007). A model of dust thermal emission taking into account a range of dust sizes is used to analyse the PACS maps, equivalent to that used in Bockelée-Morvan et al., 2010. While H2O was not detected in our 8 March 2013 observation, we derive a sensitive 3σ upper limit of Q_H_2O

Quantitative intact specimen magnetic resonance microscopy at 3.0 T.

PubMed

Bath, Kevin G; Voss, Henning U; Jing, Deqiang; Anderson, Stewart; Hempstead, Barbara; Lee, Francis S; Dyke, Jonathan P; Ballon, Douglas J

2009-06-01

In this report, we discuss the application of a methodology for high-contrast, high-resolution magnetic resonance microscopy (MRM) of murine tissue using a 3.0-T imaging system. We employed a threefold strategy that included customized specimen preparation to maximize image contrast, three-dimensional data acquisition to minimize scan time and custom radiofrequency resonator design to maximize signal sensitivity. Images had a resolution of 100 x 78 x 78 microm(3) with a signal-to-noise ratio per voxel greater than 25:1 and excellent contrast-to-noise ratios over a 30-min acquisition. We quantitatively validated the methods through comparisons of neuroanatomy across two lines of genetically engineered mice. Specifically, we were able to detect volumetric differences of as little as 9% between genetically engineered mouse strains in multiple brain regions that were predictive of underlying impairments in brain development. The overall methodology was straightforward to implement and provides ready access to basic MRM at field strengths that are widely available in both the laboratory and the clinic.

NASA Orbital Debris Large-Object Baseline Population in ORDEM 3.0

NASA Technical Reports Server (NTRS)

Krisco, Paula H.; Vavrin, A. B.; Anz-Meador, P. D.

2013-01-01

The NASA Orbital Debris Program Office (ODPO) has created and validated high fidelity populations of the debris environment for the latest Orbital Debris Engineering Model (ORDEM 3.0). Though the model includes fluxes of objects 10 um and larger, this paper considers particle fluxes for 1 cm and larger debris objects from low Earth orbit (LEO) through Geosynchronous Transfer Orbit (GTO). These are validated by several reliable radar observations through the Space Surveillance Network (SSN), Haystack, and HAX radars. ORDEM 3.0 populations were designed for the purpose of assisting, debris researchers and sensor developers in planning and testing. This environment includes a background derived from the LEO-to-GEO ENvironment Debris evolutionary model (LEGEND) with a Bayesian rescaling as well as specific events such as the FY-1C anti-satellite test, the Iridium 33/Cosmos 2251 accidental collision, and the Soviet/Russian Radar Ocean Reconnaissance Satellite (RORSAT) sodium-potassium droplet releases. The environment described in this paper is the most realistic orbital debris population larger than 1 cm, to date. We describe derivations of the background population and added specific populations. We present sample validation charts of our 1 cm and larger LEO population against Space Surveillance Network (SSN), Haystack, and HAX radar measurements.

ORDEM 3.0 and MASTER-2009 Modeled Small Debris Population Comparison

NASA Technical Reports Server (NTRS)

Krisko, P. H.; Flegel, S.

2012-01-01

The latest versions of the two premier orbital debris engineering models, NASA's ORDEM 3.0 and ESA's MASTER-2009, have been publicly released within the last year. Both models have gone through significant advancements since inception, and now represent the state-of-the-art in orbital debris knowledge of their respective agencies. The purpose of these models is to provide satellite designers/operators and debris researchers with reliable estimates of the artificial debris environment in near-Earth orbit. The small debris environment within the size range of 1 mm to 1 cm is of particular interest to both human and robotic spacecraft programs. These objects are much more numerous than larger trackable debris but are still large enough to cause significant, if not catastrophic, damage to spacecraft upon impact. They are also small enough to elude routine detection by existing observation systems (radar and telescope). Without reliable detection the modeling of these populations has always coupled theoretical origins with supporting observational data in different degrees. This paper describes the population generation and categorization of both ORDEM 3.0 and MASTER-2009; their sources (both known and presumed), current supporting data and theory, and methods of population verification. Fluxes on spacecraft for chosen orbits are presented and discussed. Future collaborative analysis is noted.

46 CFR 91.25-45 - Fire hazards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fire hazards. 91.25-45 Section 91.25-45 Shipping COAST... CERTIFICATION Inspection for Certification § 91.25-45 Fire hazards. (a) At each inspection for certification and... that there is no accumulation of oil which might create a fire hazard. [CGFR 65-50, 30 FR 16974, Dec...

Impact of the cation distribution homogeneity on the americium oxidation state in the U0.54Pu0.45Am0.01O2-x mixed oxide

NASA Astrophysics Data System (ADS)

Vauchy, Romain; Robisson, Anne-Charlotte; Martin, Philippe M.; Belin, Renaud C.; Aufore, Laurence; Scheinost, Andreas C.; Hodaj, Fiqiri

2015-01-01

The impact of the cation distribution homogeneity of the U0.54Pu0.45Am0.01O2-x mixed oxide on the americium oxidation state was studied by coupling X-ray diffraction (XRD), electron probe micro analysis (EPMA) and X-ray absorption spectroscopy (XAS). Oxygen-hypostoichiometric Am-bearing uranium-plutonium mixed oxide pellets were fabricated by two different co-milling based processes in order to obtain different cation distribution homogeneities. The americium was generated from β- decay of 241Pu. The XRD analysis of the obtained compounds did not reveal any structural difference between the samples. EPMA, however, revealed a high homogeneity in the cation distribution for one sample, and substantial heterogeneity of the U-Pu (so Am) distribution for the other. The difference in cation distribution was linked to a difference in Am chemistry as investigated by XAS, with Am being present at mixed +III/+IV oxidation state in the heterogeneous compound, whereas only Am(IV) was observed in the homogeneous compound. Previously reported discrepancies on Am oxidation states can hence be explained by cation distribution homogeneity effects.

Flexbar 3.0 - SIMD and multicore parallelization.

PubMed

Roehr, Johannes T; Dieterich, Christoph; Reinert, Knut

2017-09-15

High-throughput sequencing machines can process many samples in a single run. For Illumina systems, sequencing reads are barcoded with an additional DNA tag that is contained in the respective sequencing adapters. The recognition of barcode and adapter sequences is hence commonly needed for the analysis of next-generation sequencing data. Flexbar performs demultiplexing based on barcodes and adapter trimming for such data. The massive amounts of data generated on modern sequencing machines demand that this preprocessing is done as efficiently as possible. We present Flexbar 3.0, the successor of the popular program Flexbar. It employs now twofold parallelism: multi-threading and additionally SIMD vectorization. Both types of parallelism are used to speed-up the computation of pair-wise sequence alignments, which are used for the detection of barcodes and adapters. Furthermore, new features were included to cover a wide range of applications. We evaluated the performance of Flexbar based on a simulated sequencing dataset. Our program outcompetes other tools in terms of speed and is among the best tools in the presented quality benchmark. https://github.com/seqan/flexbar. johannes.roehr@fu-berlin.de or knut.reinert@fu-berlin.de. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

The US Geological Survey, digital spectral reflectance library: version 1: 0.2 to 3.0 microns

NASA Technical Reports Server (NTRS)

Clark, Roger N.; Swayze, Gregg A.; King, Trude V. V.; Gallagher, Andrea J.; Calvin, Wendy M.

1993-01-01

We have developed a digital reflectance spectral library, with management and spectral analysis software. The library includes 500 spectra of 447 samples (some samples include a series of grain sizes) measured from approximately 0.2 to 3.0 microns. The spectral resolution (Full Width Half Maximum) of the reflectance data is less than or equal to 4 nm in the visible (0.2-0.8 microns) and less than or equal 10 nm in the NIR (0.8-2.35 microns). All spectra were corrected to absolute reflectance using an NBS Halon standard. Library management software lets users search on parameters (e.g. chemical formulae, chemical analyses, purity of samples, mineral groups, etc.) as well as spectral features. Minerals from sulfide, oxide, hydroxide, halide, carbonate, nitrate, borate, phosphate, and silicate groups are represented. X-ray and chemical analyses are tabulated for many of the entries, and all samples have been evaluated for spectral purity. The library also contains end and intermediate members for the olivine, garnet, scapolite, montmorillonite, muscovite, jarosite, and alunite solid-solution series. We have included representative spectra of H2O ice, kerogen, ammonium-bearing minerals, rare-earth oxides, desert varnish coatings, kaolinite crystallinity series, kaolinite-smectite series, zeolite series, and an extensive evaporite series. Because of the importance of vegetation to climate-change studies we have include 17 spectra of tree leaves, bushes, and grasses.

RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria.

PubMed

Novichkov, Pavel S; Kazakov, Alexey E; Ravcheev, Dmitry A; Leyn, Semen A; Kovaleva, Galina Y; Sutormin, Roman A; Kazanov, Marat D; Riehl, William; Arkin, Adam P; Dubchak, Inna; Rodionov, Dmitry A

2013-11-01

Genome-scale prediction of gene regulation and reconstruction of transcriptional regulatory networks in prokaryotes is one of the critical tasks of modern genomics. Bacteria from different taxonomic groups, whose lifestyles and natural environments are substantially different, possess highly diverged transcriptional regulatory networks. The comparative genomics approaches are useful for in silico reconstruction of bacterial regulons and networks operated by both transcription factors (TFs) and RNA regulatory elements (riboswitches). RegPrecise (http://regprecise.lbl.gov) is a web resource for collection, visualization and analysis of transcriptional regulons reconstructed by comparative genomics. We significantly expanded a reference collection of manually curated regulons we introduced earlier. RegPrecise 3.0 provides access to inferred regulatory interactions organized by phylogenetic, structural and functional properties. Taxonomy-specific collections include 781 TF regulogs inferred in more than 160 genomes representing 14 taxonomic groups of Bacteria. TF-specific collections include regulogs for a selected subset of 40 TFs reconstructed across more than 30 taxonomic lineages. Novel collections of regulons operated by RNA regulatory elements (riboswitches) include near 400 regulogs inferred in 24 bacterial lineages. RegPrecise 3.0 provides four classifications of the reference regulons implemented as controlled vocabularies: 55 TF protein families; 43 RNA motif families; ~150 biological processes or metabolic pathways; and ~200 effectors or environmental signals. Genome-wide visualization of regulatory networks and metabolic pathways covered by the reference regulons are available for all studied genomes. A separate section of RegPrecise 3.0 contains draft regulatory networks in 640 genomes obtained by an conservative propagation of the reference regulons to closely related genomes. RegPrecise 3.0 gives access to the transcriptional regulons reconstructed in

45 CFR 1306.30 - Provisions of comprehensive child development services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... development of the child. (c) The facilities used by Early Head Start and Head Start grantee and delegate... 45 Public Welfare 4 2010-10-01 2010-10-01 false Provisions of comprehensive child development... CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START STAFFING REQUIREMENTS AND PROGRAM OPTIONS Head...

Political, policy and social barriers to health system interoperability: emerging opportunities of Web 2.0 and 3.0.

PubMed

Juzwishin, Donald W M

2009-01-01

Achieving effective health informatics interoperability in a fragmented and uncoordinated health system is by definition not possible. Interoperability requires the simultaneous integration of health care processes and information across different types and levels of care (systems thinking). The fundamental argument of this paper is that information system interoperability will remain an unfulfilled hope until health reforms effectively address the governance (accountability), structural and process barriers to interoperability of health care delivery. The ascendency of Web 2.0 and 3.0, although still unproven, signals the opportunity to accelerate patients' access to health information and their health record. Policy suggestions for simultaneously advancing health system delivery and information system interoperability are posited.

Multicenter Evaluation of the Vitek MS v3.0 System for the Identification of Filamentous Fungi.

PubMed

Rychert, Jenna; Slechta, E Sue; Barker, Adam P; Miranda, Edwin; Babady, N Esther; Tang, Yi-Wei; Gibas, Connie; Wiederhold, Nathan; Sutton, DeAnna; Hanson, Kimberly E

2018-02-01

Invasive fungal infections are an important cause of morbidity and mortality affecting primarily immunocompromised patients. While fungal identification to the species level is critical to providing appropriate therapy, it can be slow and laborious and often relies on subjective morphological criteria. The use of matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry has the potential to speed up and improve the accuracy of identification. In this multicenter study, we evaluated the accuracy of the Vitek MS v3.0 system in identifying 1,601 clinical mold isolates compared to identification by DNA sequence analysis and supported by morphological and phenotypic testing. Among the 1,519 isolates representing organisms in the v3.0 database, 91% ( n = 1,387) were correctly identified to the species level. An additional 27 isolates (2%) were correctly identified to the genus level. Fifteen isolates were incorrectly identified, due to either a single incorrect identification ( n = 13) or multiple identifications from different genera ( n = 2). In those cases, when a single identification was provided that was not correct, the misidentification was within the same genus. The Vitek MS v3.0 was unable to identify 91 (6%) isolates, despite repeat testing. These isolates were distributed among all the genera. When considering all isolates tested, even those that were not represented in the database, the Vitek MS v3.0 provided a single correct identification 98% of the time. These findings demonstrate that the Vitek MS v3.0 system is highly accurate for the identification of common molds encountered in the clinical mycology laboratory. Copyright © 2018 American Society for Microbiology.

The Reliability and Validity of the Japanese Version of the Stroke Impact Scale Version 3.0.

PubMed

Ochi, Mitsuhiro; Ohashi, Hiroshi; Hachisuka, Kenji; Saeki, Satoru

It is important to evaluate body functions and structures, activity, and participation in stroke rehabilitation. The Stroke Impact Scale (SIS), a new stroke-specific self-report measure that was developed by Duncan et al, is widely used to measure multidimensional consequences about health-related quality of life. The SIS version 3.0 includes 9 domains (strength, hand function, activity of daily living and instrumental activity of daily living, mobility, communication, emotion, memory and thinking, participation, and recovery). Patients are asked to make a percentage rating of their recovery since their stroke on a visual analog scale of 0 to 100 for the stroke recovery domain. Each item in the 8 domains other than stroke recovery are scored in a range of 1 to 5 as a raw score and calculated using the manual to a final score. We developed a Japanese version of the SIS version 3.0 and assessed its reliability and validity in 32 chronic stroke survivors. The internal consistency (Cronbach's α < 0.70) was satisfactory. The test-retest reliability (ICC, 0.86 to 0.96) was also satisfactory. Regarding convergent validity, a significant correlation (Spearman's correlation coefficient, P < 0.05) was found between the SIS physical domain score and Brunnstrom stage (r, 0.49 to 0.53) and short form 8 (r = 0.82). The Japanese version of the SIS version 3.0 is valid, reliable, and clinically useful for stroke survivors.

Inter-speaker speech variability assessment using statistical deformable models from 3.0 tesla magnetic resonance images.

PubMed

Vasconcelos, Maria J M; Ventura, Sandra M R; Freitas, Diamantino R S; Tavares, João Manuel R S

2012-03-01

The morphological and dynamic characterisation of the vocal tract during speech production has been gaining greater attention due to the motivation of the latest improvements in magnetic resonance (MR) imaging; namely, with the use of higher magnetic fields, such as 3.0 Tesla. In this work, the automatic study of the vocal tract from 3.0 Tesla MR images was assessed through the application of statistical deformable models. Therefore, the primary goal focused on the analysis of the shape of the vocal tract during the articulation of European Portuguese sounds, followed by the evaluation of the results concerning the automatic segmentation, i.e. identification of the vocal tract in new MR images. In what concerns speech production, this is the first attempt to automatically characterise and reconstruct the vocal tract shape of 3.0 Tesla MR images by using deformable models; particularly, by using active and appearance shape models. The achieved results clearly evidence the adequacy and advantage of the automatic analysis of the 3.0 Tesla MR images of these deformable models in order to extract the vocal tract shape and assess the involved articulatory movements. These achievements are mostly required, for example, for a better knowledge of speech production, mainly of patients suffering from articulatory disorders, and to build enhanced speech synthesizer models.

Structural, dielectric and magnetic studies of (x) Mg0.2Cu0.3Zn0.5Fe2O4 + (1-x) Ba0.8Zr0.2TiO3 magnetoelectric composites

NASA Astrophysics Data System (ADS)

Khader, S. Abdul; Giridharan, N. V.; Chaudhuri, Arka; Sankarappa, T.

2016-05-01

The Magneto-electric composites (x) Mg0.2Cu0.3Zn0.5Fe2O4 + (1-x) Ba0.8Zr0.2TiO3 (x=15%,30%,45%) were synthesized by sintering mixtures of highly ferroelectric Ba0.8Zr0.2TiO3 (BZT) and highly magneto-strictive component Mg0.2Cu0.3Zn0.5Fe2O4 (MCZF). The presences of two phases in magneto-electric composites were probed by X-ray diffraction (XRD) studies. The peaks observed in the XRD spectrum indicated spinel cubic structure for MCZF ferrite and tetragonal perovskite structure for BZT and, both spinel and pervoskite structures for synthesized composites. Surface morphology of the samples has been investigated using Field Emission Scanning Electron Microscope (FESEM). Frequency dependent dielectric properties of synthesized composites were measured from 100 Hz to 1 MHz at RT using HIOKI LCR HI-TESTER. The dielectric dispersion is observed at lower frequencies for the synthesized ME composites. The magnetic properties of synthesized composites were analyzed using a Vibrating Sample Magnetometer (VSM). It is observed that the values of saturation magnetization increases along with the ferrite content.

30 CFR 917.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... inspection pursuant to 30 CFR 740.4(c)(5), and in a timely fashion which will not exceed 45 calendar days... face that in the event the Federal Lands Cooperative Agreement between Kentucky and the U.S. Department...

30 CFR 917.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... inspection pursuant to 30 CFR 740.4(c)(5), and in a timely fashion which will not exceed 45 calendar days... face that in the event the Federal Lands Cooperative Agreement between Kentucky and the U.S. Department...

Integrated test system of infrared and laser data based on USB 3.0

NASA Astrophysics Data System (ADS)

Fu, Hui Quan; Tang, Lin Bo; Zhang, Chao; Zhao, Bao Jun; Li, Mao Wen

2017-07-01

Based on USB3.0, this paper presents the design method of an integrated test system for both infrared image data and laser signal data processing module. The core of the design is FPGA logic control, the design uses dual-chip DDR3 SDRAM to achieve high-speed laser data cache, and receive parallel LVDS image data through serial-to-parallel conversion chip, and it achieves high-speed data communication between the system and host computer through the USB3.0 bus. The experimental results show that the developed PC software realizes the real-time display of 14-bit LVDS original image after 14-to-8 bit conversion and JPEG2000 compressed image after decompression in software, and can realize the real-time display of the acquired laser signal data. The correctness of the test system design is verified, indicating that the interface link is normal.

ZCURVE 3.0: identify prokaryotic genes with higher accuracy as well as automatically and accurately select essential genes

PubMed Central

Hua, Zhi-Gang; Lin, Yan; Yuan, Ya-Zhou; Yang, De-Chang; Wei, Wen; Guo, Feng-Biao

2015-01-01

In 2003, we developed an ab initio program, ZCURVE 1.0, to find genes in bacterial and archaeal genomes. In this work, we present the updated version (i.e. ZCURVE 3.0). Using 422 prokaryotic genomes, the average accuracy was 93.7% with the updated version, compared with 88.7% with the original version. Such results also demonstrate that ZCURVE 3.0 is comparable with Glimmer 3.02 and may provide complementary predictions to it. In fact, the joint application of the two programs generated better results by correctly finding more annotated genes while also containing fewer false-positive predictions. As the exclusive function, ZCURVE 3.0 contains one post-processing program that can identify essential genes with high accuracy (generally >90%). We hope ZCURVE 3.0 will receive wide use with the web-based running mode. The updated ZCURVE can be freely accessed from http://cefg.uestc.edu.cn/zcurve/ or http://tubic.tju.edu.cn/zcurveb/ without any restrictions. PMID:25977299

Comparison of diffusion-weighted MRI acquisition techniques for normal pancreas at 3.0 Tesla.

PubMed

Yao, Xiu-Zhong; Kuang, Tiantao; Wu, Li; Feng, Hao; Liu, Hao; Cheng, Wei-Zhong; Rao, Sheng-Xiang; Wang, He; Zeng, Meng-Su

2014-01-01

We aimed to optimize diffusion-weighted imaging (DWI) acquisitions for normal pancreas at 3.0 Tesla. Thirty healthy volunteers were examined using four DWI acquisition techniques with b values of 0 and 600 s/mm2 at 3.0 Tesla, including breath-hold DWI, respiratory-triggered DWI, respiratory-triggered DWI with inversion recovery (IR), and free-breathing DWI with IR. Artifacts, signal-to-noise ratio (SNR) and apparent diffusion coefficient (ADC) of normal pancreas were statistically evaluated among different DWI acquisitions. Statistical differences were noticed in artifacts, SNR, and ADC values of normal pancreas among different DWI acquisitions by ANOVA (P <0.001). Normal pancreas imaging had the lowest artifact in respiratory-triggered DWI with IR, the highest SNR in respiratory-triggered DWI, and the highest ADC value in free-breathing DWI with IR. The head, body, and tail of normal pancreas had statistically different ADC values on each DWI acquisition by ANOVA (P < 0.05). The highest image quality for normal pancreas was obtained using respiratory-triggered DWI with IR. Normal pancreas displayed inhomogeneous ADC values along the head, body, and tail structures.

P³DB 3.0: From plant phosphorylation sites to protein networks.

PubMed

Yao, Qiuming; Ge, Huangyi; Wu, Shangquan; Zhang, Ning; Chen, Wei; Xu, Chunhui; Gao, Jianjiong; Thelen, Jay J; Xu, Dong

2014-01-01

In the past few years, the Plant Protein Phosphorylation Database (P(3)DB, http://p3db.org) has become one of the most significant in vivo data resources for studying plant phosphoproteomics. We have substantially updated P(3)DB with respect to format, new datasets and analytic tools. In the P(3)DB 3.0, there are altogether 47 923 phosphosites in 16 477 phosphoproteins curated across nine plant organisms from 32 studies, which have met our multiple quality standards for acquisition of in vivo phosphorylation site data. Centralized by these phosphorylation data, multiple related data and annotations are provided, including protein-protein interaction (PPI), gene ontology, protein tertiary structures, orthologous sequences, kinase/phosphatase classification and Kinase Client Assay (KiC Assay) data--all of which provides context for the phosphorylation event. In addition, P(3)DB 3.0 incorporates multiple network viewers for the above features, such as PPI network, kinase-substrate network, phosphatase-substrate network, and domain co-occurrence network to help study phosphorylation from a systems point of view. Furthermore, the new P(3)DB reflects a community-based design through which users can share datasets and automate data depository processes for publication purposes. Each of these new features supports the goal of making P(3)DB a comprehensive, systematic and interactive platform for phosphoproteomics research.

Recrystallization Behavior in SAC305 and SAC305 + 3.0POSS Solder Joints Under Thermal Shock

NASA Astrophysics Data System (ADS)

Han, Jing; Gu, Penghao; Ma, Limin; Guo, Fu; Liu, Jianping

2018-04-01

Sn-3.0Ag-0.5Cu (SAC305) and SAC305 + 3.0 polyhedral oligomeric silsesquioxanes (POSS) ball grid array (BGA) assemblies have been prepared, observed, and subjected to thermal shock. The microstructure and grain orientation evolution of the solder joints located at the same position of the package were characterized by scanning electron microscopy and electron backscattering diffraction, respectively. The results showed that the microstructure of the solder joints was refined by addition of POSS particles. In addition, compared with the single-grained or tricrystal joints normally observed in SAC305 BGA solder joints, the frequency of single-grained as-reflowed SAC305 + 3.0POSS BGA joints was greatly reduced, and the solder joints were typically composed of multicrystals with orientations separated by high-angle grain boundaries. These multicrystal joints appear to be obtained by dominant tricrystals or double tricrystals with deviation of the preferred [110] and [1\\bar{1}0] growth directions of Sn dendrites in Sn-Ag-based solder alloys during solidification from the melt. After 928 thermal shock cycles, the SAC305 solder joint had large-area recrystallization and cracks in contrast to the SAC305 + 3.0POSS solder joint located at the same position of the package, indicating that addition of POSS to SAC305 solder joints may contribute to postponement of recrystallization and subsequent crack initiation and propagation along recrystallized grain boundaries by pinning grain boundaries and movement of dislocations. This finding also confirms the double tricrystal solidification twinning nucleation behavior in Pb-free solder joints.

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

PubMed Central

Strnad, Ondrej; Brezovsky, Jan; Kozlikova, Barbora; Gora, Artur; Sustr, Vilem; Klvana, Martin; Medek, Petr; Biedermannova, Lada; Sochor, Jiri; Damborsky, Jiri

2012-01-01

Tunnels and channels facilitate the transport of small molecules, ions and water solvent in a large variety of proteins. Characteristics of individual transport pathways, including their geometry, physico-chemical properties and dynamics are instrumental for understanding of structure-function relationships of these proteins, for the design of new inhibitors and construction of improved biocatalysts. CAVER is a software tool widely used for the identification and characterization of transport pathways in static macromolecular structures. Herein we present a new version of CAVER enabling automatic analysis of tunnels and channels in large ensembles of protein conformations. CAVER 3.0 implements new algorithms for the calculation and clustering of pathways. A trajectory from a molecular dynamics simulation serves as the typical input, while detailed characteristics and summary statistics of the time evolution of individual pathways are provided in the outputs. To illustrate the capabilities of CAVER 3.0, the tool was applied for the analysis of molecular dynamics simulation of the microbial enzyme haloalkane dehalogenase DhaA. CAVER 3.0 safely identified and reliably estimated the importance of all previously published DhaA tunnels, including the tunnels closed in DhaA crystal structures. Obtained results clearly demonstrate that analysis of molecular dynamics simulation is essential for the estimation of pathway characteristics and elucidation of the structural basis of the tunnel gating. CAVER 3.0 paves the way for the study of important biochemical phenomena in the area of molecular transport, molecular recognition and enzymatic catalysis. The software is freely available as a multiplatform command-line application at http://www.caver.cz. PMID:23093919

CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures.

PubMed

Chovancova, Eva; Pavelka, Antonin; Benes, Petr; Strnad, Ondrej; Brezovsky, Jan; Kozlikova, Barbora; Gora, Artur; Sustr, Vilem; Klvana, Martin; Medek, Petr; Biedermannova, Lada; Sochor, Jiri; Damborsky, Jiri

2012-01-01

Tunnels and channels facilitate the transport of small molecules, ions and water solvent in a large variety of proteins. Characteristics of individual transport pathways, including their geometry, physico-chemical properties and dynamics are instrumental for understanding of structure-function relationships of these proteins, for the design of new inhibitors and construction of improved biocatalysts. CAVER is a software tool widely used for the identification and characterization of transport pathways in static macromolecular structures. Herein we present a new version of CAVER enabling automatic analysis of tunnels and channels in large ensembles of protein conformations. CAVER 3.0 implements new algorithms for the calculation and clustering of pathways. A trajectory from a molecular dynamics simulation serves as the typical input, while detailed characteristics and summary statistics of the time evolution of individual pathways are provided in the outputs. To illustrate the capabilities of CAVER 3.0, the tool was applied for the analysis of molecular dynamics simulation of the microbial enzyme haloalkane dehalogenase DhaA. CAVER 3.0 safely identified and reliably estimated the importance of all previously published DhaA tunnels, including the tunnels closed in DhaA crystal structures. Obtained results clearly demonstrate that analysis of molecular dynamics simulation is essential for the estimation of pathway characteristics and elucidation of the structural basis of the tunnel gating. CAVER 3.0 paves the way for the study of important biochemical phenomena in the area of molecular transport, molecular recognition and enzymatic catalysis. The software is freely available as a multiplatform command-line application at http://www.caver.cz.

Planetary Mission Entry Vehicles Quick Reference Guide. Version 3.0

NASA Technical Reports Server (NTRS)

Davies, Carol; Arcadi, Marla

2006-01-01

This is Version 3.0 of the planetary mission entry vehicle document. Three new missions, Re-entry F, Hayabusa, and ARD have been added to t he previously published edition (Version 2.1). In addition, the Huyge ns mission has been significantly updated and some Apollo data correc ted. Due to the changing nature of planetary vehicles during the desi gn, manufacture and mission phases, and to the variables involved in measurement and computation, please be aware that the data provided h erein cannot be guaranteed. Contact Carol Davies at cdavies@mail.arc. nasa.gov to correct or update the current data, or to suggest other missions.

Photoproduction of Λ and Σ0 hyperons off protons with linearly polarized photons at Eγ=1.5 -3.0 GeV

NASA Astrophysics Data System (ADS)

Shiu, S. H.; Kohri, H.; Chang, W. C.; Ahn, D. S.; Ahn, J. K.; Chen, J. Y.; Daté, S.; Ejiri, H.; Fujimura, H.; Fujiwara, M.; Fukui, S.; Gohn, W.; Hicks, K.; Hotta, T.; Hwang, S. H.; Imai, K.; Ishikawa, T.; Joo, K.; Kato, Y.; Kon, Y.; Lee, H. S.; Maeda, Y.; Mibe, T.; Miyabe, M.; Mizutani, K.; Morino, Y.; Muramatsu, N.; Nakano, T.; Nakatsugawa, Y.; Niiyama, M.; Noumi, H.; Ohashi, Y.; Ohta, T.; Oka, M.; Parker, J. D.; Rangacharyulu, C.; Ryu, S. Y.; Sawada, T.; Shimizu, H.; Sugaya, Y.; Sumihama, M.; Tsunemi, T.; Uchida, M.; Ungaro, M.; Yosoi, M.; LEPS Collaboration

2018-01-01

We report the measurement of the γ p →K+Λ and γ p →K+Σ0 reactions at SPring-8. The differential cross sections and photon-beam asymmetries are measured at forward K+ production angles using linearly polarized tagged-photon beams in the range of Eγ=1.5 -3.0 GeV. With increasing photon energy, the cross sections for both γ p →K+Λ and γ p →K+Σ0 reactions decrease slowly. Distinct narrow structures in the production cross section have not been found at Eγ=1.5 -3.0 GeV. The forward peaking in the angular distributions of cross sections, a characteristic feature of t -channel exchange, is observed for the production of Λ in the whole observed energy range. A lack of similar feature for Σ0 production reflects a less dominant role of t -channel contribution in this channel. The photon-beam asymmetries remain positive for both reactions, suggesting the dominance of K* exchange in the t channel. These asymmetries increase gradually with the photon energy, and have a maximum value of +0.6 for both reactions. Comparison with theoretical predictions based on the Regge trajectory in the t channel and the contributions of nucleon resonances indicates the major role of t -channel contributions as well as non-negligible effects of nucleon resonances in accounting for the reaction mechanism of hyperon photoproduction in this photon energy regime.

NavMol 3.0: enabling the representation of metabolic reactions by blind users.

PubMed

Binev, Yuri; Peixoto, Daniela; Pereira, Florbela; Rodrigues, Ian; Cavaco, Sofia; Lobo, Ana M; Aires-de-Sousa, João

2018-01-01

The representation of metabolic reactions strongly relies on visualization, which is a major barrier for blind users. The NavMol software renders the communication and interpretation of molecular structures and reactions accessible by integrating chemoinformatics and assistive technology. NavMol 3.0 provides a molecular editor for metabolic reactions. The user can start with templates of reactions and build from such cores. Atom-to-atom mapping enables changes in the reactants to be reflected in the products (and vice-versa) and the reaction centres to be automatically identified. Blind users can easily interact with the software using the keyboard and text-to-speech technology. NavMol 3.0 is free and open source under the GNU general public license (GPLv3), and can be downloaded at http://sourceforge.net/projects/navmol as a JAR file. joao@airesdesousa.com. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

[Concept and applications of the Web 3.0: an introduction for medical doctors].

PubMed

Mayer, Miguel Angel; Leis, Angela

2010-05-01

The development of the Internet is continuous and appears to be never-ending, although with the arrival of Web 3.0 it could be said that the Internet is what its creators intended it to be from the first moment, an extraordinary and immense organised, understandable, and easy to access data base, characteristics still not achieved. The innovations and services included in Web 3.0 will result, in the first place, in better, faster and safer access to quality information. In the second place it should provide better personalisation of the health services that Internet users access, avoiding irrelevant information that may contain wrong, false and dangerous recommendations. However, these changes will have to be accompanied by the legal requirements common to the information society, by the ethical aspects associated with medical care, guaranteeing and contributing, in all cases, to improving the doctor-patient relationship. Copyright 2009 Elsevier España, S.L. All rights reserved.

Abdominal applications of 3.0-T MR imaging: comparative review versus a 1.5-T system.

PubMed

Choi, Jin-Young; Kim, Myeong-Jin; Chung, Yong Eun; Kim, Ji Youn; Jones, Alun C; de Becker, Jan; van Cauteren, Marc

2008-01-01

With the development of dedicated receiver coils and increased gradient performance, 3.0-T magnetic resonance (MR) systems are gaining wider acceptance in clinical practice. The expected twofold increase in signal-to-noise ratio (SNR) compared with that of 1.5-T MR systems may help improve spatial resolution or increase temporal resolution when used with parallel acquisition techniques. Several issues must be considered when applying 3.0-T MR in the abdomen, including the alteration of the radiofrequency field and relaxation time, increase in energy deposition and susceptibility effects, and problems associated with motion artifacts. For the evaluation of liver lesions, higher SNR and greater resolution achieved with the 3.0-T system could translate into better detection of malignant lesions on T2-weighted images obtained with adjusted imaging parameters. For the evaluation of pancreatic and biliary diseases, high-resolution T2-weighted imaging using single-shot turbo spin-echo sequences is useful; improvement in SNR was noticeable on two-dimensional MR cholangiopancreatographic images. For the preoperative imaging of rectal cancer, a single-shot sequence is useful for dramatically decreasing imaging time while maintaining image quality. Substantial modification of examination protocols, with optimized imaging parameters and sequence designs along with ongoing development of hardware, could contribute to an increased role of the 3.0-T system for abdominal MR examinations.

Cu6Sn5 Whiskers Precipitated in Sn3.0Ag0.5Cu/Cu Interconnection in Concentrator Silicon Solar Cells Solder Layer

PubMed Central

Zhang, Liang; Liu, Zhi-quan; Yang, Fan; Zhong, Su-juan

2017-01-01

Cu6Sn5 whiskers precipitated in Sn3.0Ag0.5Cu/Cu interconnection in concentrator silicon solar cells solder layer were found and investigated after reflow soldering and during aging. Ag3Sn fibers can be observed around Cu6Sn5 whiskers in the matrix microstructure, which can play an active effect on the reliability of interconnection. Different morphologies of Cu6Sn5 whiskers can be observed, and hexagonal rod structure is the main morphology of Cu6Sn5 whiskers. A hollow structure can be observed in hexagonal Cu6Sn5 whiskers, and a screw dislocation mechanism was used to represent the Cu6Sn5 growth. Based on mechanical property testing and finite element simulation, Cu6Sn5 whiskers were regarded as having a negative effect on the durability of Sn3.0Ag0.5Cu/Cu interconnection in concentrator silicon solar cells solder layer. PMID:28772686

The Chicago Classification 3.0 Results in More Normal Findings and Fewer Hypotensive Findings With No Difference in Other Diagnoses.

PubMed

Monrroy, H; Cisternas, D; Bilder, C; Ditaranto, A; Remes-Troche, J; Meixueiro, A; Zavala, M A; Serra, J; Marín, I; Ruiz de León, A; Pérez de la Serna, J; Hani, A; Leguizamo, A; Abrahao, L; Coello, R; Valdovinos, M A

2017-04-01

High-resolution manometry (HRM) is the preferred method for the evaluation of motility disorders. Recently, an update of the diagnostic criteria (Chicago 3.0) has been published. The aim of this study was to compare the performance criteria of Chicago version 2.0 (CC2.0) vs. 3.0 (CC3.0) in a cohort of healthy volunteers and symptomatic patients. HRM studies of asymptomatic and symptomatic individuals from several centers of Spain and Latin America were analyzed using both CC2.0 and CC3.0. The final diagnosis was grouped into hierarchical categories: obstruction (achalasia and gastro-esophageal junction obstruction), major disorders (distal esophageal spasm, absent peristalsis, and jackhammer), minor disorders (failed frequent peristalsis, weak peristalsis with small or large defects, ineffective esophageal motility, fragmented peristalsis, rapid contractile with normal latency and hypertensive peristalsis) and normal. The results were compared using McNemar's and Kappa tests. HRM was analyzed in 107 healthy volunteers (53.3% female; 18-69 years) and 400 symptomatic patients (58.5% female; 18-90 years). In healthy volunteers, using CC2.0 and CC3.0, obstructive disorders were diagnosed in 7.5% and 5.6%, respectively, major disorders in 1% and 2.8%, respectively, minor disorders in 25.2% and 15%, respectively, and normal in 66.4% and 76.6%, respectively. In symptomatic individuals, using CC2.0 and CC3.0, obstructive disorders were diagnosed in 11% and 11.3%, respectively, major disorders in 14% and 14%, respectively, minor disorders in 33.3% and 24.5%, respectively, and normal in 41.8% and 50.3%, respectively. In both groups of individuals, only an increase in normal and a decrease in minor findings using CC3.0 were statistically significant using McNemar's test. CC3.0 increases the number of normal studies when compared with CC2.0, essentially at the expense of fewer minor disorders, with no significant differences in major or obstructive disorders. As the relevance

Assessment of the cervical spine denticulate ligament using MRI volumetric sequence: Comparison between 1.5 Tesla and 3.0 Tesla.

PubMed

Seragioli, Rafael; Simao, Marcelo Novelino; Simao, Gustavo Novelino; Herrero, Carlos Fernando P S; Nogueira-Barbosa, Marcello H

2018-03-01

Denticulate ligaments (DLs) are pial extensions on each side of the spinal cord, comprising about 20 to 21 pairs of fibrous structures connecting the dura mater to the spinal cord. These ligaments are significant anatomical landmarks in the surgical approach to intradural structures. To our knowledge, there is no previous study on the detection of DLs using MRI. After IRB approval, we retrospectively evaluated 116 consecutive MRI scans of the cervical spine, using the volumetric sequence 3D COSMIC, 65 and 51 studies with 1.5T and 3.0T respectively. We did not include trauma and tumor cases. Two independent radiologists assessed the detection of cervical spine DLs independently and blinded for each cervical vertebral level. We compared the frequency of detection of these ligaments in 1.5 Tesla and 3.0 Tesla MRI using Fisher exact test considering P<0.05 as significant. We evaluated interobserver agreement with Kappa coefficient. We observed high detection frequency of the cervical spine DLs using both 1.5T (70 to 91%) and 3.0T (68 to 98%). We found no statistically significant difference in the detection frequency of ligaments between the 1.5T and 3.0T MRI in all vertebral levels. Using 3.0T, radiologists identified ligaments better in higher vertebral levels than for lower cervical levels (P=0.0003). Interobserver agreement on the identification of DL was poor both for 1.5T (k=0.3744; CI 95% 0.28-0.46) and 3.0T (k=0.3044; CI 95% 0.18-0.42) MRI. Radiologists identified most of the cervical DLs using volumetric MRI acquisition. Our results suggest 1.5T and 3.0T MRI performed similarly in the detection of DLs. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

GeoChip 3.0: A High Throughput Tool for Analyzing Microbial Community, Composition, Structure, and Functional Activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Zhili; Deng, Ye; Nostrand, Joy Van

2010-05-17

Microarray-based genomic technology has been widely used for microbial community analysis, and it is expected that microarray-based genomic technologies will revolutionize the analysis of microbial community structure, function and dynamics. A new generation of functional gene arrays (GeoChip 3.0) has been developed, with 27,812 probes covering 56,990 gene variants from 292 functional gene families involved in carbon, nitrogen, phosphorus and sulfur cycles, energy metabolism, antibiotic resistance, metal resistance, and organic contaminant degradation. Those probes were derived from 2,744, 140, and 262 species for bacteria, archaea, and fungi, respectively. GeoChip 3.0 has several other distinct features, such as a common oligomore » reference standard (CORS) for data normalization and comparison, a software package for data management and future updating, and the gyrB gene for phylogenetic analysis. Our computational evaluation of probe specificity indicated that all designed probes had a high specificity to their corresponding targets. Also, experimental analysis with synthesized oligonucleotides and genomic DNAs showed that only 0.0036percent-0.025percent false positive rates were observed, suggesting that the designed probes are highly specific under the experimental conditions examined. In addition, GeoChip 3.0 was applied to analyze soil microbial communities in a multifactor grassland ecosystem in Minnesota, USA, which demonstrated that the structure, composition, and potential activity of soil microbial communities significantly changed with the plant species diversity. All results indicate that GeoChip 3.0 is a high throughput powerful tool for studying microbial community functional structure, and linking microbial communities to ecosystem processes and functioning. To our knowledge, GeoChip 3.0 is the most comprehensive microarrays currently available for studying microbial communities associated with geobiochemical cycling, global climate change

Ultra-thin L1{sub 0}-FePt for perpendicular anisotropy L1{sub 0}-FePt/Ag/[Co/Pd]{sub 30} pseudo spin valves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ho, Pin; Chow, Gan Moog; Chen, Jing-Sheng, E-mail: msecj@nus.edu.sg

2014-05-07

Perpendicular anisotropy L1{sub 0}-FePt/Ag/[Co/Pd]{sub 30} pseudo spin valves (PSVs) with ultra-thin L1{sub 0}-FePt alloy free layer possessing high anisotropy and thermal stability have been fabricated and studied. The thickness of the L1{sub 0}-FePt layer was varied between 2 and 4 nm. The PSV became increasingly decoupled with reduced L1{sub 0}-FePt thickness due to the larger difference between the coercivity of the L1{sub 0}-FePt and [Co/Pd]{sub 30} films. The PSV with an ultra-thin L1{sub 0}-FePt free layer of 2 nm displayed a high K{sub u} of 2.21 × 10{sup 7} ergs/cm{sup 3}, high thermal stability of 84 and a largest giant magnetoresistance of 0.54%.