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Sample records for issledovanie reaktsii 235unth

  1. Lichnost' i ee formirovanie v detskom vozraste: psihologiceskoe issledovanie (Personality and Its Development in Childhood: A Psychological Investigation).

    ERIC Educational Resources Information Center

    Bozovic, L. I.

    This document is an English-language abstract (approximately 1,500 words) of a three-part volume on the psychology of child personality development. In part one, the author shows that psychology is one of the most important scientific disciplines on which education is based, particularly because of its contribution to the scientific planning of…

  2. Influence of eNOS gene 4a/b VNTR polymorphism on development of endothelial dysfunction and respiratory system disorders in children - residents of radioactively contaminated areas.

    PubMed

    Stepanova, Ye I; Kolpakov, Ye; Zyhalo, V M; Lytvynets, O M; Kondrashova, V H; Vdovenko, V Yu; Skvarska, O O; Leonovych, O S

    2015-12-01

    Meta roboty – doslidyty rol' polimorfizmu geniv eNOS u rozvytku endotelial'noI dysfunktsiI ta funktsional' nykh rozladiv systemy dykhannia u ditey – meshkantsiv radioaktyvno zabrudnenykh terytoriy.Materialy i metody doslidzhennia. Dlia vyznachennia mozhlyvykh asotsiatyvnykh zv’iazkiv polimorfizmu u 4 mu introni gena eNOS z pokaznykamy, shcho kharakteryzuiut' funktsional'nyy stan endoteliiu ta bronkholegenevoI sys temy, provedeno obstezhennia 184 ditey. Z nykh osnovnu grupu sklaly 135 ditey – meshkantsiv radioaktyvno zabrud nenykh terytoriy, kontrol'nu – 49 ditey, iaki prozhyvaly v „chystykh ” shchodo radioaktyvnogo zabrudnennia regionakh i ne nalezhaly do postrazhdalykh vnaslidok Chornobyl's'koI avariI kontyngentiv. Provodyly molekuliarno gene tychne doslidzhennia z vyznachenniam polimorfizmu v 4 mu introni gena eNOS. Doslidzhennia ventyliatsiynoI spro mozhnosti legeniv otsiniuvaly za dopomogoiu metodu pnevmotakhografiI. Dlia reiestratsiI endoteliyzalezhnoI reaktsiI sudynnogo rusla na zminy umov krovopostachannia vykorystovuvaly termografichnyy sposib. Vyznachennia rivniv azotystykh spoluk NO2 ta NO3 provodyly za standartnoiu metodykoiu z vykorystanniam reaktyvu Grissa. Riven' inkorporovanogo 137Cs v organizmi vyznachaly za dopomogoiu lichyl'nyka vyprominiuvannia liudyny Skrynner 3M vyrobnytstva Instytutu ekologiI liudyny.Rezul'taty. Dity osnovnoI grupy za chastotoiu polimorfnykh 4a/b genotypiv ta aleliv 4a i 4b gena eNOS ne vidriznia lysia vid kontroliu ta danykh literatury. U ditey osnovnoI grupy z genotypom 4a/4b u porivnianni z dit'my, iaki ma ly genotyp 4b/4b, vidmichalosia zbil'shennia tryvalosti vidnovlennia krovoobigu do vykhidnogo rivnia pislia ok liuziynoI proby; sposterigalosia znyzhennia vmistu nitrytu v syrovattsi krovi; zmenshennia integral'nykh pokaznykiv elastychnosti i roztiazhnosti legenevoI tkanyny, prokhidnosti dykhal'nykh shliakhiv; u 1,5 raza chastishe reiestruvalysia oznaky bronkhospazmu. Tsi nespryiatlyvi efekty buly

  3. Expression of Cyclin d1 protein and CCND1 та PNKP genes in peripheral blood mononuclear cells in clean up worker of Chornobyl accident with different state of immune system.

    PubMed

    Bazyka, D A; Kubashko, A V; Ilyenko, I M; Belyaev, O A; Pleskach, O J

    2015-12-01

    Meta. Doslidyty zminy rivniv Cyclin D1+ klityn ta asotsiyovanykh geniv CCND1 ta PNKP u mononuklearakh peryfe rychnoI krovi v uchasnykiv likvidatsiI naslidkiv avariI (ULNA) na ChAES z riznym imunnym statusom v zalezhnosti vid dozy oprominennia.Materialy i metody. Proanalizovano vidnosnyy riven' Cyclin D1+ klityn u mononuklearakh peryferychnoI krovi 39 ULNA na ChAES, cholovikiv, oprominenykh u dozi u diapazoni (0,01–2,00) Gr. Imunologichnyy status obstezhenykh vyz nachavsia za rivnem CD3/19, CD4/8, CD3/HLA DR, SD3/16/56 metodom protochnoI tsytofluorymetriI ta za vmistom Ig klasiv A,M,G metodom imunofermentnogo analizu u krovi. Ekspresiia geniv CCND1 ta PNKP, iaki pov’iazani z Syclin D1, provodylos' za metodom polimeraznoI lantsiugovoI reaktsiI u real'nomu chasi. Porivniannia rezul'tativ zdiysniuva los' iz vidpovidnymy danymy, otrymanymy vid 18 zdorovykh cholovikiv, iaki ne maly kontaktu z ionizuiuchym vyp rominiuvanniam vyshche pryrodn'ogo fonu.Rezul'taty. Pokazano, shcho vidsotok Suclin D1+ klityn zbil'shuiet'sia za normu v osib, oprominenykh u dozi > 0,1 Gr, ta koreliuie z dozoiu oprominennia (rs = 0,417, p = 0,048). Vidkhylennia rivnia Cyclin D1+ klityn za mezhi kontrol'nykh zna chen' pov’iazuiet'sia zi zminamy v klitynniy ta gumoral'niy lankakh imunitetu. Zmenshennia vidsotku Cyclin D1+ klityn za mezhi kontrol'nykh znachen' v ULNA na ChAES iz dozoiu < 0,35 Gr suprovodzhuiet'sia znyzhenniam rivniv CD3+ ta pidvy shchenniam CD3 16+56+ limfotsytiv; u osib, oprominenykh u dozi > 0,35 Gr, zbil'shennia vidsotku Cyclin D1+ klityn asotsiiuiet'sia zi znyzhenniam CD3+ ta tendentsiieiu shchodo znyzhennia CD3+16+56+ limfotsytiv u poiednanni zi zbil'shen niam rivnia IgG. Zbil'shennia rivniv CD4+, CD19+, Ireg. ta IgG suprovodzhuiet'sia poiavoiu koreliatsiynykh zv’iazkiv mizh Cyclin D1+ ta CD3 16+56+ klitynamy (rs = 0,872, p = 0,049), Cyclin D1+ ta CD8+ i IgG (rs = 0,683, p = 0,042; rs = 0,809, p = 0,014), Cyclin D1+ ta CD4+ (rs = 0,602, p = 0,029), Cyclin D1+ ta CD19+ i