Sample records for issue entitled functional

  1. Special Issue: "Functional Dendrimers".

    PubMed

    Tomalia, Donald A

    2016-08-09

    This special issue entitled "Functional Dendrimers" focuses on the manipulation of at least six "critical nanoscale design parameters" (CNDPs) of dendrimers including: size, shape, surface chemistry, flexibility/rigidity, architecture and elemental composition. These CNDPs collectively define properties of all "functional dendrimers". This special issue contains many interesting examples describing the manipulation of certain dendrimer CNDPs to create new emerging properties and, in some cases, predictive nanoperiodic property patterns (i.e., dendritic effects). The systematic engineering of CNDPs provides a valuable strategy for optimizing functional dendrimer properties for use in specific applications.

  2. 21 CFR 1306.03 - Persons entitled to issue prescriptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Persons entitled to issue prescriptions. 1306.03 Section 1306.03 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE PRESCRIPTIONS General Information § 1306.03 Persons entitled to issue prescriptions. (a) A prescription for a controlled...

  3. 75 FR 39667 - Availability for Non-Exclusive or Partially Exclusive Licensing of a U.S. Patent Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ..., which issued on December 15, 2009, entitled ``Use of Shigella Invaplex to Transport Functional Proteins... Functional Proteins and Transcriptionally Active Nucleic Acids Across Mammalian Cell Membranes In Vitro and... functional proteins and biologically active nucleic acids, across eukaryotic cell membranes. Brenda S. Bowen...

  4. Riparian ecosystems and buffers - multiscale structure, function, and management: introduction

    Treesearch

    Kathleen A. Dwire; Richard R. Lowrance

    2006-01-01

    Given the importance of issues related to improved understanding and management of riparian ecosystems and buffers, the American Water Resources Association (AWRA) sponsored a Summer Specialty Conference in June 2004 at Olympic Valley, California, entitled 'Riparian Ecosystems and Buffers: Multiscale Structure, Function, and Management.' The primary objective...

  5. 78 FR 75336 - Notice of Intent To Grant a Partially Exclusive License; Aviation Devices and Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ...: issued January 21, 2011, Navy Case No. PAX53 entitled ``Active Aluminum Rich Coatings''//U.S. Patent No. 8,277,688: issued October 2, 2012, Navy Case No. PAX81 entitled ``Aluminum Alloy Coated Pigments and....: 13/628,323 filed September 27, 2012, Navy Case No. PAX121 entitled ``Coated Aluminum Alloy Pigments...

  6. 78 FR 26783 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    ...; Public Health Service Guideline on Infectious Disease Issues on Xenotransplantation AGENCY: Food and Drug... collection of information entitled ``Public Health Service Guideline on Infectious Disease Issues on... information entitled ``Public Health Service Guideline on Infectious Disease Issues on Xenotransplantation...

  7. Responses to Horner and Carr.

    ERIC Educational Resources Information Center

    Durand, V. Mark; And Others

    1997-01-01

    Five special educators (Durand, Bambara, Dunlap, Kennedy, and Wacker) respond to an article in the same issue by Horner and Carr entitled "Behavioral Support for Students with Severe Disabilities: Functional Assessment and Comprehensive Intervention." Respondents raise concerns regarding the range of intervention options, the behavioral…

  8. Workshop on Functional Aspects of Regeneration of the Boreal Forest in the Context of Sustainable Forest Management

    Treesearch

    Christian Messier; John Zasada; David Greene

    1999-01-01

    The three review papers presented in this issue of the Canadian Journal of Forest Research follow a 1-day workshop that was held in Montreal in early January 1997 entitled Functional Aspects of Regeneration In the Boreal Forest in the Context of Sustainable Forest Management. This workshop was held as part of the regeneration working group of Canada...

  9. Academic Entitlement in Pharmacy Education

    PubMed Central

    Romanelli, Frank; Smith, Kelly M.

    2012-01-01

    The constructs of academic entitlement and student consumerism refer to students’ attitudes toward education as a commodity and the underlying belief that as consumers, they should be catered to and given the opportunity to participate in the education process according to their preferences. Most discussions regarding these attitudes are anecdotal, but the pervasiveness of these accounts and the troubling effects that ensue warrant attention. Grade inflation, student incivility, altered classroom practices, and decreased faculty morale are all potential aftereffects of teaching students who hold academic entitlement beliefs. Numerous factors are posited as attributing to academic entitlement including personal issues, societal pressures, and broad academic practices. This paper discusses these factors and offers faculty members and administrators recommendations regarding practices that may curb or alleviate issues associated with academically entitled students. PMID:23275654

  10. Student Entitlement: Issues and Strategies for Confronting Entitlement in the Classroom and Beyond

    ERIC Educational Resources Information Center

    Lippmann, Stephen; Bulanda, Ronald E.; Wagenaar, Theodore C.

    2009-01-01

    While not representative of all students, those who demonstrate a sense of entitlement demand a great deal of instructors' time and energy. Our article places student entitlement in its social context, with specific attention to the prevalence of the consumer mentality, grade inflation, and the self-esteem of the student generation. We then…

  11. A Government Action Approach to First Amendment Analysis.

    ERIC Educational Resources Information Center

    Walden, Ruth

    1992-01-01

    Suggests focusing on the actions of government that restrict free expression rather than focusing on the values served by freedom of expression. Bases the approach on the premise that the court's function is to determine when a particular government action violates the First Amendment, not whether the expression at issue is entitled to…

  12. Signalling mechanisms in autophagy: an introduction to the issue.

    PubMed

    Lane, Jon D; Korolchuk, Viktor I; Murray, James T

    2017-12-12

    Essays in Biochemistry volume 61 (issue 6), entitled Signalling Mechanisms in Autophagy , covers a range of topics in autophagy signalling, touching on emerging new details on the mechanisms of autophagy regulation, novel aspects of selective autophagy and how autophagy functions in organelle homeostasis. It also looks at how autophagy research is leading to better understanding of human disease and plant biology that can be exploited for the benefit of society. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

  13. Equity and Entitlement: Internal Barriers to Improving the Pay of Academic Librarians.

    ERIC Educational Resources Information Center

    Kirkland, Janice J.

    1991-01-01

    Discussion of the salaries of academic librarians focuses on the female majority in librarianship and women's lower sense of entitlement. Topics discussed include cognitive reevaluation; circumscribing the field of librarianship for salary comparison; and issues of entitlement and equity as they relate to self-esteem. (16 references) (LRW)

  14. The K-turn motif in riboswitches and other RNA species☆

    PubMed Central

    Lilley, David M.J.

    2014-01-01

    The kink turn is a widespread structure motif that introduces a tight bend into the axis of duplex RNA. This generally functions to mediate tertiary interactions, and to serve as a specific protein binding site. K-turns or closely related structures are found in at least seven different riboswitch structures, where they function as key architectural elements that help generate the ligand binding pocket. This article is part of a Special Issue entitled: Riboswitches. PMID:24798078

  15. A Critique of Julie L. Ozanne, Natalie Ross Adkins, and Jennifer A. Sandlin's: "Shopping {For} Power: How Adult Literacy Learners Negotiate"

    ERIC Educational Resources Information Center

    Coutinho, Colin

    2008-01-01

    This paper will review the article entitled, "Shopping {For} Power: How Adult Literacy Learners Negotiate" [EJ756994] by authors Julie L. Ozanne, Natalie Ross Adkins, and Jennifer A. Sandlin. The authors argue that functional literacy in the United States is an important issue and needs to play a larger role in adult literacy programs.…

  16. Grandparents' entitlements and obligations.

    PubMed

    Draper, Heather

    2013-07-01

    In this article, it is argued that grandparents' obligations originate from parental obligations (i.e from the relationship they have with their children, the parents of their grandchildren) and not from the role of grandparent per se, and any entitlements flow from the extent to which these obligations are met. The position defended is, therefore, that grandparents qua grandparents are not entitled to form or continue relationships with their grandchildren. A continuation of grandparent-grandchildren relationships may be in the interests of children, but the grandparental nature of the relationship is not decisive. What counts is the extent to which relationships children have with any adults who are not their parents are is significant to them. Sometimes, however, grandparents become parents or co-parents of their grandchildren. They then gain parental rights, and as such are as entitled, ceteris parius, as any parent to expect their relationship with the child to continue. The issue of grandparents' entitlements can come to the fore when parents separate, and grandparents are unhappy with the access they have to their grandchildren. Grandparents' obligations may become a particular issue when parents die, struggle, or fail to care for their children. This article focuses particularly on these kinds of circumstances. © 2013 John Wiley & Sons Ltd.

  17. GRANDPARENTS' ENTITLEMENTS AND OBLIGATIONS

    PubMed Central

    Draper, Heather

    2013-01-01

    In this article, it is argued that grandparents' obligations originate from parental obligations (i.e from the relationship they have with their children, the parents of their grandchildren) and not from the role of grandparent per se, and any entitlements flow from the extent to which these obligations are met. The position defended is, therefore, that grandparents qua grandparents are not entitled to form or continue relationships with their grandchildren. A continuation of grandparent-grandchildren relationships may be in the interests of children, but the grandparental nature of the relationship is not decisive. What counts is the extent to which relationships children have with any adults who are not their parents are is significant to them. Sometimes, however, grandparents become parents or co-parents of their grandchildren. They then gain parental rights, and as such are as entitled, ceteris parius, as any parent to expect their relationship with the child to continue. The issue of grandparents' entitlements can come to the fore when parents separate, and grandparents are unhappy with the access they have to their grandchildren. Grandparents' obligations may become a particular issue when parents die, struggle, or fail to care for their children. This article focuses particularly on these kinds of circumstances. PMID:23718643

  18. 78 FR 31398 - Visas: Documentation of Immigrants Under the Immigration and Nationality Act, as Amended

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Immigrants Under the Immigration and Nationality Act, as Amended AGENCY: Department of State. ACTION: Final... method of recording an alien's entitlement to an immigrant visa classification. Due to the availability of automated systems at all immigrant visa-issuing posts, this entitlement is now recorded...

  19. 78 FR 37670 - Federal Acquisition Regulation; Contractors Performing Private Security Functions Outside the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ...] RIN 9000-AM20 Federal Acquisition Regulation; Contractors Performing Private Security Functions...-181). Section 862, entitled ``Contractors Performing Private Security Functions in Areas of Combat...), as amended, entitled ``Contractors Performing Private Security Functions in Areas of Combat...

  20. Reward and aversion in a heterogeneous midbrain dopamine system.

    PubMed

    Lammel, Stephan; Lim, Byung Kook; Malenka, Robert C

    2014-01-01

    The ventral tegmental area (VTA) is a heterogeneous brain structure that serves a central role in motivation and reward processing. Abnormalities in the function of VTA dopamine (DA) neurons and the targets they influence are implicated in several prominent neuropsychiatric disorders including addiction and depression. Recent studies suggest that the midbrain DA system is composed of anatomically and functionally heterogeneous DA subpopulations with different axonal projections. These findings may explain a number of previously confusing observations that suggested a role for DA in processing both rewarding as well as aversive events. Here we will focus on recent advances in understanding the neural circuits mediating reward and aversion in the VTA and how stress as well as drugs of abuse, in particular cocaine, alter circuit function within a heterogeneous midbrain DA system. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Comments on Professor Lortie's Paper Entitled "The Cracked Cake of Educational Custom and Emerging Issues in Evaluation." Center for the Study of Evaluation of Instructional Programs Occasional Report No. 20.

    ERIC Educational Resources Information Center

    Gordon, C. Wayne

    This paper suggests that the variety of decision making proposed by Professor Lortie will not afford the luxury of evaluative systems of the kind he describes. Professor Gordon feels that, had Professor Lortie pursued a line of functional analysis of many outcomes, he would have arrived at an entirely new analysis of the justification for…

  2. Intellectual Freedom and Economic Sufficiency as Educational Entitlements.

    ERIC Educational Resources Information Center

    Morse, Jane Fowler

    2001-01-01

    Using the theories of John Stuart Mill and Karl Marx, this article supports the educational entitlements of intellectual freedom and economic sufficiency. Explores these issues in reference to their implications for teaching, the teaching profession and its training. Concludes that ideas cannot be controlled by the interests of the dominant class.…

  3. 75 FR 3163 - Vocational Rehabilitation and Employment Program-Basic Entitlement; Effective Date of Induction...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... implemented changes to services provided under 38 U.S.C. chapter 31, which resulted from a court decision and..., for vocational rehabilitation basic entitlement determinations resulting from the Veterans' Benefits... issuing any rule that may result in the expenditure by State, local, and Tribal governments, in the...

  4. TESL Reporter, Vol. 4, No. 2.

    ERIC Educational Resources Information Center

    Pack, Alice C., Ed.

    This issue of "TESL Reporter" presents results of a 1970 English as a Second Language (ESL) textbook survey conducted by the English Language Institute and reported by Alice C. Pack; an article by Julene Evans entitled "Why TESL?"; and an article by Yao Shen entitled "Supplementation of Opposites in Simple Predicate Expansion." Of the 1,200 mailed…

  5. A Module for the Administration of Homebound Instructional Programs

    ERIC Educational Resources Information Center

    Wasserman, Lewis

    2008-01-01

    Special program and other school administrators regularly confront the issue of whether students under their charge are entitled to receive homebound instruction and if so, what procedures and criteria they should apply in coming to a proper decision. Where a student is entitled to such services the administrator must decide what subjects must be…

  6. ERCMExpress. Volume 3, Issue 4

    ERIC Educational Resources Information Center

    Taymans, Mary Frances; McDonald, Dale

    2007-01-01

    The Emergency Response and Crisis Management (ERCM) Technical Assistance Center's "ERCMExpress" is a newsletter that provides comprehensive information on key issues in school emergency management. This issue, entitled "Emergency Management Opportunities and Challenges for Non-Public Schools," examines integrating non-public…

  7. 77 FR 38275 - Notice of Intent To Grant Exclusive Patent License; Emerging Growth Enterprise LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ..., nonassignable, exclusive license to practice in the field of fire fighting foam discharge and suppression... November 6, 2007) and entitled, ``Nofoam system for testing a foam delivery system on a vehicle'', No. 7,293,478 (Issued November 13, 2007) and entitled ``Method for testing a foam delivery system on a...

  8. 14 CFR 21.257 - Type certificates: issue.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Type certificates: issue. 21.257 Section 21.257 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... certificates: issue. An applicant is entitled to a type certificate for a product manufactured under a...

  9. 14 CFR 21.257 - Type certificates: issue.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Type certificates: issue. 21.257 Section 21.257 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... certificates: issue. An applicant is entitled to a type certificate for a product manufactured under a...

  10. 75 FR 8313 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... entitled ``Composition and process for removing and preventing mildew and fungal growth'' issued on... and preventing mildew and fungal growth'' issued on December 8, 2009. ADDRESSES: Requests for data and...

  11. IVHS institutional issues and case studies : ADVANCE case study

    DOT National Transportation Integrated Search

    1994-04-01

    This operational test case study is one of six performed in response to a Volpe National Transportation Systems Center technical task directive (TTD) to Science Applications International Corporation (SAIC) entitled, IVHS Institutional Issues and ...

  12. Introduction

    Treesearch

    Sheila E. Ward; David Boshier; James Grogan

    2008-01-01

    This special issue of Forest Ecology and Management addresses management issues for the tropical timber species of the Meliaceae. The concept for this issue originated from a technical session entitled ..Sustainable management of highvalue timber species of the Meliaceae: a global perspective.., held at the 2005 World Congress of the International Union of Forest...

  13. Permissive Parenting and Mental Health in College Students: Mediating Effects of Academic Entitlement

    ERIC Educational Resources Information Center

    Barton, Alison L.; Hirsch, Jameson K.

    2016-01-01

    Objective: Student mental health may suffer due to unreasonable expectations associated with academic entitlement; permissive parenting may be one source of these expectations. The authors examined the role of academic entitlement as a mediator of the relationship between permissive parenting and psychological functioning. Participants:…

  14. 14 CFR 125.27 - Issue of certificate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Issue of certificate. 125.27 Section 125.27... AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS CERTIFICATION AND OPERATIONS... Requirements § 125.27 Issue of certificate. (a) An applicant for a certificate under this subpart is entitled...

  15. Using Service Learning in a Course Entitled "Biology of Women" to Promote Student Engagement and Awareness of Community Needs and Resources

    ERIC Educational Resources Information Center

    Bauer-Dantoin, Angela C.

    2008-01-01

    Service learning projects were incorporated into the curriculum of an undergraduate course entitled "Biology of Women". The goals of the service learning projects were: 1) to provide students with the opportunity to consider issues pertaining to human biology in real-world settings; 2) to foster student engagement with the community; and…

  16. Eyeglass Benefits: Consideration of Frame of Choice for Retired Service Members

    DTIC Science & Technology

    2009-04-20

    20100329217 t. ABSTRACT ’he Department of Defense (DoD) provides basic eyewear to our nation’s military members. .Ithough not specifically entitled under...Title X, military retirees historically also receive tandard issue eyewear . The military’s Frame of Choice (FOC) program currently benefits the...current fiscal environment. . SUBJECT TERMS ^eglasses, Frame of Choice, Retiree, Service Members, Entitlements, Eyewear , snefit, Optometry, Optical

  17. Predicting Academic Entitlement in Undergraduates

    ERIC Educational Resources Information Center

    Sohr-Preston, Sara; Boswell, Stefanie S.

    2015-01-01

    Academic entitlement (AE) is a common source of frustration for college personnel. This investigation examined predictors (self-concept, academic dishonesty, locus of control, and family functioning) of AE in male and female college students. Academic dishonesty and the interaction between locus of control and family functioning significantly…

  18. Phosphoinositides: Key modulators of energy metabolism☆

    PubMed Central

    Bridges, Dave; Saltiel, Alan R.

    2014-01-01

    Phosphoinositides are key players in many trafficking and signaling pathways. Recent advances regarding the synthesis, location and functions of these lipids have dramatically improved our understanding of how and when these lipids are generated and what their roles are in animal physiology. In particular, phosphoinositides play a central role in insulin signaling, and manipulation of PtdIns(3,4,5)P3 levels in particular, may be an important potential therapeutic target for the alleviation of insulin resistance associated with obesity and the metabolic syndrome. In this article we review the metabolism, regulation and functional roles of phosphoinositides in insulin signaling and the regulation of energy metabolism. This article is part of a Special Issue entitled Phosphoinositides. PMID:25463477

  19. Oxytocin and the social brain: neural mechanisms and perspectives in human research.

    PubMed

    Kanat, Manuela; Heinrichs, Markus; Domes, Gregor

    2014-09-11

    The present paper summarizes functional imaging studies investigating the effects of intranasal oxytocin (OT) on brain responses to social stimuli. We aim to integrate previous research, point to unresolved issues and highlight perspectives for future studies. The studies so far have focused on identifying neural circuits underlying social information processing which are particularly sensitive to modulations by exogenous OT. Most consistently, stimulus-related responses of the amygdala and associated areas within the prefrontal and temporal cortices have been found to be modulated by OT administration. However, there are a number of unresolved issues related to the possible role of sex differences and hormonal status, genetic variability, and individual differences in socio-cognitive functioning. Future studies focusing on these open questions are expected to contribute to a more nuanced understanding of the role of the central OT system in humans and may provide the basis for novel treatment approaches for mental disorders characterized by social deficits. This article is part of a Special Issue entitled Oxytocin and Social Behav. © 2013 Published by Elsevier B.V.

  20. Doing Local History.

    ERIC Educational Resources Information Center

    Ohrn, Deborah Gore, Ed.

    1992-01-01

    This theme issue contains articles about the importance of learning local history. The lead article includes historical information about three Iowa cities: Council Bluffs, Waterloo, and Jefferson. Other features in this issue are entitled: "Iowa Kids Talk,""Digging Into Local History,""Goldie's Top Ten News Stories";…

  1. 76 FR 26290 - Science Advisory Board Staff Office; Notification of a Public Teleconference of the Chartered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... report entitled ``SAB Review of EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to... of EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments.'' The SAB... Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments.'' To conduct this review...

  2. 75 FR 62514 - Notice of Availability of Report on Data Access and Privacy Issues Related to Smart Grid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... DEPARTMENT OF ENERGY Notice of Availability of Report on Data Access and Privacy Issues Related to... report entitled, ``Data Access and Privacy Issues Related to Smart Grid Technologies.'' In this report... meeting conducted during the preparation of the report. This report responds to recommendations for DOE...

  3. Formation of Teachers as Leaders: Response to the Articles in This Special Issue

    ERIC Educational Resources Information Center

    Frick, William C.; Browne-Ferrigno, Tricia

    2016-01-01

    This article contains a response to three manuscripts that are part of the "JRLE" special issue entitled Developing and Empowering Teacher Leaders for Collective Leadership. Discussion of the articles, lessons learned, and implications for teacher leadership development are discussed.

  4. A Rainbow of Qualitative Approaches and Concerns.

    ERIC Educational Resources Information Center

    Fetterman, David M.

    1987-01-01

    Reviews the seven papers presented at a symposium entitled "Perennial Issues in Qualitative Research," part of the Annual Meeting of the American Educational Research Association (San Francisco, California, 1986), and included in this issue. Discusses the demonstrated usefulness of qualitative methods in educational research, and also…

  5. Gene therapy for eye as regenerative medicine? Lessons from RPE65 gene therapy for Leber's Congenital Amaurosis.

    PubMed

    Rakoczy, Elizabeth P; Narfström, Kristina

    2014-11-01

    Recombinant virus mediated gene therapy of Leber's Congenital Amaurosis has provided a wide range of data on the utility of gene replacement therapy for recessive diseases. Studies to date demonstrate that gene therapy in the eye is safe and can result in long-term recovery of visual function, but they also highlight that further research is required to identify optimum intervention time-points, target populations and the compatibility of associate therapies. This article is part of a directed issue entitled: Regenerative Medicine: the challenge of translation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Enhance, delete, incept: Manipulating hippocampus-dependent memories☆

    PubMed Central

    Spiers, Hugo J.; Bendor, Daniel

    2014-01-01

    Here we provide a brief overview of recent research on memory manipulation. We focus primarily on memories for which the hippocampus is thought to be required due to its central importance in the study of memory. The repertoire of methods employed is expanding and includes optogenetics, transcranial stimulation, deep brain stimulation, cued reactivation during sleep and the use of pharmacological agents. In addition, the possible mechanisms underlying these memory changes have been investigated using techniques such as single unit recording and functional magnetic resonance imaging (fMRI). This article is part of a Special Issue entitled ‘Memory enhancement’. PMID:24397964

  7. Teaching Research Integrity and Bioethics to Science Undergraduates

    ERIC Educational Resources Information Center

    Turrens, Julio F.

    2005-01-01

    Undergraduate students in the Department of Biomedical Sciences at the University of South Alabama, Mobile, are required to take a course entitled "Issues in Biomedical Sciences," designed to increase students' awareness about bioethical questions and issues concerning research integrity. This paper describes the main features of this…

  8. AGING AND TOXIC RESPONSE: ISSUES RELEVANT TO RISK ASSESSMENT (FINAL)

    EPA Science Inventory

    EPA has released a final report entitled, Aging and Toxic Response: Issues Relevant to Risk Assessment. This document contributes to the Agency's efforts to better understand the physiology of aging in order to protect the health of older persons, and identifies several d...

  9. First principles design of a core bioenergetic transmembrane electron-transfer protein

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goparaju, Geetha; Fry, Bryan A.; Chobot, Sarah E.

    Here we describe the design, Escherichia coli expression and characterization of a simplified, adaptable and functionally transparent single chain 4-α-helix transmembrane protein frame that binds multiple heme and light activatable porphyrins. Such man-made cofactor-binding oxidoreductases, designed from first principles with minimal reference to natural protein sequences, are known as maquettes. This design is an adaptable frame aiming to uncover core engineering principles governing bioenergetic transmembrane electron-transfer function and recapitulate protein archetypes proposed to represent the origins of photosynthesis. This article is part of a Special Issue entitled Biodesign for Bioenergetics — the design and engineering of electronic transfer cofactors, proteinsmore » and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson.« less

  10. SMP-domain proteins at membrane contact sites: Structure and function.

    PubMed

    Reinisch, Karin M; De Camilli, Pietro

    2016-08-01

    SMP-domains are found in proteins that localize to membrane contact sites. Elucidation of the properties of these proteins gives clues as to the molecular bases underlying processes that occur at such sites. Described here are recent discoveries concerning the structure, function, and regulation of the Extended-Synaptotagmin proteins and ERMES complex subunits, SMP-domain proteins at endoplasmic reticulum (ER)-plasma membrane and ER-mitochondrial contacts, respectively. They act as tethers contributing to the architecture of these sites and as lipid transporters that convey glycerolipids between apposed membranes. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. Copyright © 2016. Published by Elsevier B.V.

  11. Humanities Perspectives on Technology Program: Science, Technology & Society Program. Lehigh University, 1977-80.

    ERIC Educational Resources Information Center

    Cutcliffe, Stephen H., Ed.

    Newsletter issues pertaining to Lehigh University's Humanities Perspectives on Technology (HPT) Program, which was renamed the Science, Technology and Society Program, are presented. Additionally, a newsletter article excerpt entitled "Elements of Technology in a Liberal Education" is included. Two 1977 issues of "HRP News,"…

  12. 76 FR 70680 - Small Business Size Standards: Real Estate and Rental and Leasing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... industries and one sub- industry in North American Industry Classification System (NAICS) Sector 53, Real... industries grouped by NAICS Sector. SBA issued a White Paper entitled ``Size Standards Methodology'' and published in the October 21, 2009 issue of the Federal Register. That ``Size Standards Methodology'' is...

  13. The Affective Side: Gifted Identification and the Call to Advocacy.

    ERIC Educational Resources Information Center

    Strop, Jean

    2003-01-01

    This article lists common pitfalls in parents' gifted advocacy attempts: believing exceptionality is synonymous with entitlement; responding to stated boredom without determining the meaning; waiting for a crisis before advocating; pushing for a response before agreeing on the issue; and advocating from their own issues. Strategies for developing…

  14. Water, water quality and health (Chapter 3 in Book entitled: Environmental Tracking for Public Health Surveillance).

    EPA Science Inventory

    This chapter identifies the role environmental tracking plays in identifying public health water hazard and water quality issues. It outlines public health issues to be examined and provides an integrated overview of water and diseases by combining knowledge of the hydrological ...

  15. Identity Development Process and Content: Toward an Integrated and Contextualized Science of Identity

    ERIC Educational Resources Information Center

    Galliher, Renee V.; Rivas-Drake, Deborah; Dubow, Eric F.

    2017-01-01

    This introductory summary provides an overview of the content of the special issue entitled "Identity Development Process and Content: Toward an Integrated and Contextualized Science of Identity." The 16 theoretical and empirical articles that comprise this special issue were selected to highlight innovative methodologies, theoretical…

  16. Optimizing Wartime Materiel Delivery: An Overview of DoD containerization. Volume 2. Framework for Action to Address DoD Containerization Issues

    DOT National Transportation Integrated Search

    1988-10-01

    This second volume of the study entitled, Optimizing Wartime Materiel Delivery: An Overview of DOD Containerization Efforts, -outlines a framework for action to address containerization issues identified in Volume I. The objectives of the study inclu...

  17. Testing Programs in Schools: What's New? A Special Issue.

    ERIC Educational Resources Information Center

    Walter, L. James; And Others

    1981-01-01

    This special issue of "Catalyst", entitled Testing Programs in Schools: What's New?, was published jointly by the Nebraska Council of School Administrators and the Nebraska Association for Supervision and Curriculum. The articles emphasize desirability of designing testing programs to meet the information needs of educators and the…

  18. Unlearning Whiteness, Rethinking Race Issues in Graduate Music Education

    ERIC Educational Resources Information Center

    Bradley, Deborah; Golner, Ronald; Hanson, Sarah

    2007-01-01

    This paper examines the experiences of music education graduate students and their instructor during a fifteen-week seminar course entitled "Race issues in music teaching." Excerpts from students' journal entries and the instructor's responses to those journals are constructed in this paper as dialogue vignettes which provide insight…

  19. PREFACE OF SPECIAL ISSUE OF AEROSOL SCIENCE AND TECHNOLOGY FOR PARTICULATE MATTER SUPERSITES PROGRAM AND RELATED STUDIES

    EPA Science Inventory

    This article is the preface or editors note to a dedicated issue of Aerosol Science and Technology, journal of the American Association for Aerosol Research. It includes a selection of scientific papers from the specialty conference entitled, "Particulate Matter Supersites ...

  20. Papers on Theoretical Issues in Health Education.

    ERIC Educational Resources Information Center

    California Univ., Berkeley. School of Public Health.

    This document is a collection of 17 papers on theoretical issues in health education presented at the Dorothy Nyswander International Symposium. The introduction, entitled "Theory and Practice in Health Education: A Synthesis," attempts to highlight some of the features of these papers and their relevance for health education practice. The papers…

  1. [Luís Gomes Ferreira reports on the health of slaves in his work entitled Erário mineral (1735)].

    PubMed

    Eugênio, Alisson

    2015-01-01

    The article analyzes the reports of Luís Gomes Ferreira published in his manual on practical medicine entitled Erário mineral, of 1735, on the most common illnesses in captivity. It is shown that such reports can be interpreted as a criticism of the social relations of the slave era by issuing some warnings to the landowners who failed to look after the health of their slaves.

  2. RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

    PubMed Central

    Metzger, Meredith B.; Pruneda, Jonathan N.; Klevit, Rachel E.; Weissman, Allan M.

    2013-01-01

    RING finger domain and RING finger-like ubiquitin ligases (E3s), such as U-box proteins, constitute the vast majority of known E3s. RING-type E3s function together with ubiquitin-conjugating enzymes (E2s) to mediate ubiquitination and are implicated in numerous cellular processes. In part because of their importance in human physiology and disease, these proteins and their cellular functions represent an intense area of study. Here we review recent advances in RING-type E3 recognition of substrates, their cellular regulation, and their varied architecture. Additionally, recent structural insights into RING-type E3 function, with a focus on important interactions with E2s and ubiquitin, are reviewed. This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. PMID:23747565

  3. Permissive parenting and mental health in college students: Mediating effects of academic entitlement.

    PubMed

    Barton, Alison L; Hirsch, Jameson K

    2016-01-01

    Student mental health may suffer due to unreasonable expectations associated with academic entitlement; permissive parenting may be one source of these expectations. The authors examined the role of academic entitlement as a mediator of the relationship between permissive parenting and psychological functioning. Participants were 524 undergraduate students at a single institution (52% female; age range = 18-22). Data collection was completed in May 2011. Cross-sectional design. Participants completed online self-report measures of parenting styles, academic entitlement, stress, depressive symptoms, and well-being. Permissive parenting was associated with greater academic entitlement and, in turn, to more perceived stress and poorer mental health. Mother/father differences were found in some cases. Academic entitlement may partially explain why permissive parenting is detrimentally related to mental health for college students. Implications for academic affairs and counseling include helping students develop an appreciation of the role of self-regulation in college success.

  4. 14 CFR 147.5 - Application and issue.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OTHER CERTIFICATED AGENCIES AVIATION MAINTENANCE TECHNICIAN SCHOOLS General § 147.5 Application and... the requirements of this part is entitled to an aviation maintenance technician school certificate and...

  5. Company Directory

    ERIC Educational Resources Information Center

    Environmental Science and Technology, 1972

    1972-01-01

    Alphabetical listing of manufacturers and suppliers of the products and services listed in this issue of Environmental Science and Technology entitled Pollution Control Directory, 1972-73.'' Information relative to pollution control and abatement. (LK)

  6. User Acceptance Of Commercial Vehicle Operations (CVO) Services, Critical Issues Relating To Acceptance Of CVO Services By Interstate Truck And Bus Drivers, Final Report, Task B Report

    DOT National Transportation Integrated Search

    1995-08-08

    PENN + SCHOEN ASSOCIATES HAS BEEN COMMISSIONED BY THE FEDERAL HIGHWAY ADMINISTRATION TO CONDUCT A STUDY ENTITLED "USER ACCEPTANCE OF COMMERCIAL VEHICLE OPERATIONS (CVO) SERVICES." THE PURPOSE OF THIS STUDY IS TO IDENTIFY AND EVALUATE CRITICAL ISSUES ...

  7. Key Issues in Sex Education: Reflecting on Teaching, Learning and Assessment

    ERIC Educational Resources Information Center

    Oerton, Sarah; Bowen, Helen

    2014-01-01

    Drawing upon critical reflections of staff and student experiences of teaching, learning and assessment on an undergraduate module entitled Key Issues in Sex Education, we discuss the strategies used to engage students in debates around sex and relationships education (SRE). To date, there is little research which evaluates how formal assessments…

  8. 31 CFR 360.35 - Payment (redemption).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... earlier, will be paid at any time after six months from issue date. A Series I bond issued on February 1... STATES SAVINGS BONDS, SERIES I General Provisions for Payment § 360.35 Payment (redemption). (a) General. Payment of a Series I savings bond will be made to the person or persons entitled under the provisions of...

  9. 31 CFR 360.35 - Payment (redemption).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... earlier, will be paid at any time after six months from issue date. A Series I bond issued on February 1... STATES SAVINGS BONDS, SERIES I General Provisions for Payment § 360.35 Payment (redemption). (a) General. Payment of a Series I savings bond will be made to the person or persons entitled under the provisions of...

  10. 31 CFR 360.35 - Payment (redemption).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... earlier, will be paid at any time after six months from issue date. A Series I bond issued on February 1... STATES SAVINGS BONDS, SERIES I General Provisions for Payment § 360.35 Payment (redemption). (a) General. Payment of a Series I savings bond will be made to the person or persons entitled under the provisions of...

  11. 31 CFR 360.35 - Payment (redemption).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... earlier, will be paid at any time after six months from issue date. A Series I bond issued on February 1... STATES SAVINGS BONDS, SERIES I General Provisions for Payment § 360.35 Payment (redemption). (a) General. Payment of a Series I savings bond will be made to the person or persons entitled under the provisions of...

  12. 31 CFR 360.35 - Payment (redemption).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... earlier, will be paid at any time after six months from issue date. A Series I bond issued on February 1... STATES SAVINGS BONDS, SERIES I General Provisions for Payment § 360.35 Payment (redemption). (a) General. Payment of a Series I savings bond will be made to the person or persons entitled under the provisions of...

  13. SPECIAL ISSUE OF THE JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION ON THE PARTICULATE MATTER SUPERSITES PROGRAM AND RELATED STUDIES

    EPA Science Inventory

    This article is the preface or editors note to the dedicated issue of the Journal of the Air & Waste Management Association for a selection of scientific papers from the specialty conference entitled, "Particulate Matter Supersites Program and Related Studies," that was...

  14. Morphometry, geometry, function, and the future.

    PubMed

    Mcnulty, Kieran P; Vinyard, Christopher J

    2015-01-01

    The proliferation of geometric morphometrics (GM) in biological anthropology and more broadly throughout the biological sciences has resulted in a multitude of studies that adopt landmark-based approaches for addressing a variety of questions in evolutionary morphology. In some cases, particularly in the realm of systematics, the fit between research question and analytical design is quite good. Functional-adaptive studies, however, do not readily conform to the methods available in the GM toolkit. The symposium organized by Terhune and Cooke entitled "Assessing function via shape: What is the place of GM in functional morphology?" held at the 2013 meetings of the American Association of Physical Anthropologists was designed specifically to explore this relationship between landmark-based methods and analyses of functional morphology, and the articles in this special issue, which stem in large part from this symposium, provide numerous examples of how the two approaches can complement and contrast each other. Here, we underscore some of the major difficulties in interpreting GM results within a functional regime. In combination with other contributions in this issue, we identify emerging areas of research that will help bridge the gap between multivariate morphometry and functional-adaptive analysis. Ultimately, neither geometric nor functional morphometric approaches is sufficient to elaborate the adaptive pathways that explain morphological evolution through natural selection. These perspectives must be further integrated with research from physiology, developmental biology, genomics, and ecology. © 2014 Wiley Periodicals, Inc.

  15. Hogan's framework for the study of behavior as applied to personality psychology.

    PubMed

    Ashton, Michael C

    2015-08-01

    Hogan's framework for the study of behavior can be used as a guide to the study of personality, considered here as interindividual differences in typical behavioral tendency. For any given dimension of personality variation, one can examine its development, its causal biological bases, its genetic and environmental origins, and its function and evolutionary history. These topics are discussed after a brief introduction to personality assessment and structure, and are followed by a brief review of personality research on non-human animals. This article is part of a Special Issue entitled: In Honor of Jerry Hogan. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

    PubMed

    Aymé, Ségolène; Bockenhauer, Detlef; Day, Simon; Devuyst, Olivier; Guay-Woodford, Lisa M; Ingelfinger, Julie R; Klein, Jon B; Knoers, Nine V A M; Perrone, Ronald D; Roberts, Julia; Schaefer, Franz; Torres, Vicente E; Cheung, Michael; Wheeler, David C; Winkelmayer, Wolfgang C

    2017-10-01

    Rare kidney diseases encompass at least 150 different conditions, most of which are inherited. Although individual rare kidney diseases raise specific issues, as a group these rare diseases can have overlapping challenges in diagnosis and treatment. These challenges include small numbers of affected patients, unidentified causes of disease, lack of biomarkers for monitoring disease progression, and need for complex care. To address common clinical and patient issues among rare kidney diseases, the KDIGO Controversies Conference entitled, Common Elements in Rare Kidney Diseases, brought together a panel of multidisciplinary clinical providers and patient advocates to address five central issues for rare kidney diseases. These issues encompassed diagnostic challenges, management of kidney functional decline and progression of chronic kidney disease, challenges in clinical study design, translation of advances in research to clinical care, and provision of practical and integrated patient support. Thus, by a process of consensus, guidance for addressing these challenges was developed and is presented here. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  17. Understanding the relationship between DNA methylation and histone lysine methylation☆

    PubMed Central

    Rose, Nathan R.; Klose, Robert J.

    2014-01-01

    DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become clear that the DNA and histone lysine methylation systems are highly interrelated and rely mechanistically on each other for normal chromatin function in vivo. Here we examine some of the functional links between these systems, with a particular focus on several recent discoveries suggesting how lysine methylation may help to target DNA methylation during development, and vice versa. In addition, the emerging role of non-methylated DNA found in CpG islands in defining histone lysine methylation profiles at gene regulatory elements will be discussed in the context of gene regulation. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification — looking at transcription and beyond. PMID:24560929

  18. Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases.

    PubMed

    Brandes, Ralf P; Weissmann, Norbert; Schröder, Katrin

    2014-08-01

    The only known function of the Nox family of NADPH oxidases is the production of reactive oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the ROS locally produced are required for synthesis of hormones or tissue components. In the cardiovascular system, Nox enzymes are low abundant and function as redox-modulators. By reacting with thiols, nitric oxide (NO) or trace metals, Nox-derived ROS elicit a plethora of cellular responses required for physiological growth factor signaling and the induction and adaptation to pathological processes. The interactions of Nox-derived ROS with signaling elements in the cardiovascular system are highly diverse and will be detailed in this article, which is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System". Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Entitlement to Sickness Benefits in Sweden: The Social Insurance Officers Experiences

    PubMed Central

    Söderberg, Elsy; Müssener, Ulrika

    2008-01-01

    Background: Social insurance offices (SIOs) handle a wide range of complex assessments of the entitlement to sickness benefits for an increasing number of clients on sick leave and consequently, the demands on the SIOs have increased considerably. Aim: To gain deeper knowledge of the problems experienced by the SIOs in their work associated with entitlement to sickness benefits. Method: A descriptive and explorative qualitative approach was used to analyse data from two focus-group interviews, including six participants in each group. Results: The participants discussed different dilemmas in regard to; physicians’ responsibility for issuing sickness certificates, interactions with the insured individuals, disclosure of decisions, communications with medical consultants, documentation of sickness benefit claims, threats in the workplace, as well as their own competence. The SIOs regarded incomplete information on sickness certificates as a main problem, because they frequently had to contact the client and the physicians who issued the certificates in order to obtain further details, leading to delays in the decision-making whether to grant sickness benefits. Conclusions: More knowledge regarding SIOs work is required to improve the methods used in the sickness insurance system and to ensure adequate training of new staff members. PMID:21572827

  20. BDNF in fragile X syndrome.

    PubMed

    Castrén, Maija L; Castrén, Eero

    2014-01-01

    Fragile X syndrome (FXS) is a monogenic disorder that is caused by the absence of FMR1 protein (FMRP). FXS serves as an excellent model disorder for studies investigating disturbed molecular mechanisms and synapse function underlying cognitive impairment, autism, and behavioral disturbance. Abnormalities in dendritic spines and synaptic transmission in the brain of FXS individuals and mouse models for FXS indicate perturbations in the development, maintenance, and plasticity of neuronal network connectivity. However, numerous alterations are found during the early development in FXS, including abnormal differentiation of neural progenitors and impaired migration of newly born neurons. Several aspects of FMRP function are modulated by brain-derived neurotrophic factor (BDNF) signaling. Here, we review the evidence of the role for BDNF in the developing and adult FXS brain. This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Incorporation of Ethical and Societal Issues in Biochemistry into a Senior Seminar Course

    ERIC Educational Resources Information Center

    Caspers, Mary Lou; Roberts-Kirchhoff, Elizabeth S.

    2003-01-01

    In their senior year, biochemistry majors at the University of Detroit Mercy take a senior seminar course entitled "Recent Advances in Biochemistry Related to Societal Issues." Students read papers selected from the current literature and take turns presenting these papers to the class. Papers are grouped into units dealing with molecular biology,…

  2. Neuronal basis of speech comprehension.

    PubMed

    Specht, Karsten

    2014-01-01

    Verbal communication does not rely only on the simple perception of auditory signals. It is rather a parallel and integrative processing of linguistic and non-linguistic information, involving temporal and frontal areas in particular. This review describes the inherent complexity of auditory speech comprehension from a functional-neuroanatomical perspective. The review is divided into two parts. In the first part, structural and functional asymmetry of language relevant structures will be discus. The second part of the review will discuss recent neuroimaging studies, which coherently demonstrate that speech comprehension processes rely on a hierarchical network involving the temporal, parietal, and frontal lobes. Further, the results support the dual-stream model for speech comprehension, with a dorsal stream for auditory-motor integration, and a ventral stream for extracting meaning but also the processing of sentences and narratives. Specific patterns of functional asymmetry between the left and right hemisphere can also be demonstrated. The review article concludes with a discussion on interactions between the dorsal and ventral streams, particularly the involvement of motor related areas in speech perception processes, and outlines some remaining unresolved issues. This article is part of a Special Issue entitled Human Auditory Neuroimaging. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Science and technology review, July/August 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Upadhye, R.

    This month`s issues are entitled Assuring the Safety of Nuclear Power; The Microtechnology Center, When Smaller is Better; Speeding the Gene Hunt: High Speed DNA Sequencing; and Microbial Treatments of High Explosives.

  4. 77 FR 47820 - Mid-Atlantic Fishery Management Council (MAFMC); Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... Science, will hold a workshop entitled ``Modeling Protogynous Hermaphrodite Fishes.'' DATES: The workshop... discuss data needs and modeling strategies. Although non-emergency issues not contained in this agenda may...

  5. Address By Frances "Sissy" Farenthold

    ERIC Educational Resources Information Center

    Farenthold, Frances

    1978-01-01

    Discusses the need for child advocates in the schools and the issues presented in two books entitled "The Plug-In Drug" and "All Our Children". Presented at the IAPPW Convention, Houston, Texas, 1977. (Author/HLM)

  6. 75 FR 42431 - Notice of Intent To Grant Partially Exclusive License; METOCEAN Data System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... exclusive license, with exclusive fields of use in portable acoustic scoring, acoustic sounding and..., issued February 7, 2006, entitled ``Integrated Maritime Portable Acoustic Scoring and Simulator Control...

  7. Auditory neuroimaging with fMRI and PET.

    PubMed

    Talavage, Thomas M; Gonzalez-Castillo, Javier; Scott, Sophie K

    2014-01-01

    For much of the past 30 years, investigations of auditory perception and language have been enhanced or even driven by the use of functional neuroimaging techniques that specialize in localization of central responses. Beginning with investigations using positron emission tomography (PET) and gradually shifting primarily to usage of functional magnetic resonance imaging (fMRI), auditory neuroimaging has greatly advanced our understanding of the organization and response properties of brain regions critical to the perception of and communication with the acoustic world in which we live. As the complexity of the questions being addressed has increased, the techniques, experiments and analyses applied have also become more nuanced and specialized. A brief review of the history of these investigations sets the stage for an overview and analysis of how these neuroimaging modalities are becoming ever more effective tools for understanding the auditory brain. We conclude with a brief discussion of open methodological issues as well as potential clinical applications for auditory neuroimaging. This article is part of a Special Issue entitled Human Auditory Neuroimaging. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Aquaporins in the eye: Expression, function, and roles in ocular disease☆

    PubMed Central

    Schey, Kevin L.; Wang, Zhen; Wenke, Jamie L.; Qi, Ying

    2015-01-01

    Background All thirteen known mammalian aquaporins have been detected in the eye. Moreover, aquaporins have been identified as playing essential roles in ocular functions ranging from maintenance of lens and corneal transparency to production of aqueous humor to maintenance of cellular homeostasis and regulation of signal transduction in the retina. Scope of review This review summarizes the expression and known functions of ocular aquaporins and discusses their known and potential roles in ocular diseases. Major conclusions Aquaporins play essential roles in all ocular tissues. Remarkably, not all aquaporin function as a water permeable channel and the functions of many aquaporins in ocular tissues remain unknown. Given their vital roles in maintaining ocular function and their roles in disease, aquaporins represent potential targets for future therapeutic development. General significance Since aquaporins play key roles in ocular physiology, an understanding of these functions is important to improving ocular health and treating diseases of the eye. It is likely that future therapies for ocular diseases will rely on modulation of aquaporin expression and/or function. This article is part of a Special Issue entitled Aquaporins. PMID:24184915

  9. Science and technology review, March 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Upadhye, R.

    The articles in this month`s issue are entitled Site 300`s New Contained Firing Facility, Computational Electromagnetics: Codes and Capabilities, Ergonomics Research:Impact on Injuries, and The Linear Electric Motor: Instability at 1,000 g`s.

  10. Clinical Problem Solving: The Case of John, Part II--Excerpts from Sessions 2-7

    ERIC Educational Resources Information Center

    Drell, Martin J.; Josephson, Allan; Pleak, Richard; Riggs, Paula; Rosenfeld, Alvin

    2006-01-01

    This article is part two of the three part series of articles entitled "Clinical Problem Solving: The Case of John," with excerpts from Sessions 2-7. In this article, the authors give their responses to sessions 2-7. One author talks about psychodynamic issues and developmental issues, as well as family interaction and intrapsychic problems in…

  11. Coming to Justice: A Program for Youth around Issues of International Justice

    ERIC Educational Resources Information Center

    van Driel, Barry

    2005-01-01

    In this article I describe the origins, aims and content of a program developed by the Anne Frank House around issues of international justice. The program, designed for high school and university students who are 17-years-old and older, and entitled "Coming to Justice", takes the betrayal of Jews during the Holocaust as its starting…

  12. Leveraging Emerging Technology to Maintain Corporate Situational Awareness

    DTIC Science & Technology

    2008-06-01

    Abstract and Outline for 13th ICCRTS For the paper entitled: Leveraging Emerging Technology to Maintain Corporate ...Situational Awareness Topics: Topic 5. Organizational Issues Topic 4. Cognitive and Social Issues Topic: 2 Networks and Networking Mr. José...for the collection of information is estimated to average 1 hour per response , including the time for reviewing instructions, searching existing data

  13. Complementary uses of small angle X-ray scattering and X-ray crystallography.

    PubMed

    Pillon, Monica C; Guarné, Alba

    2017-11-01

    Most proteins function within networks and, therefore, protein interactions are central to protein function. Although stable macromolecular machines have been extensively studied, dynamic protein interactions remain poorly understood. Small-angle X-ray scattering probes the size, shape and dynamics of proteins in solution at low resolution and can be used to study samples in a large range of molecular weights. Therefore, it has emerged as a powerful technique to study the structure and dynamics of biomolecular systems and bridge fragmented information obtained using high-resolution techniques. Here we review how small-angle X-ray scattering can be combined with other structural biology techniques to study protein dynamics. This article is part of a Special Issue entitled: Biophysics in Canada, edited by Lewis Kay, John Baenziger, Albert Berghuis and Peter Tieleman. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.

    PubMed

    Olson, D K; Fröhlich, F; Farese, R V; Walther, T C

    2016-08-01

    Sphingolipids are important structural membrane components of eukaryotic cells, and potent signaling molecules. As such, their levels must be maintained to optimize cellular functions in different cellular membranes. Here, we review the current knowledge of homeostatic sphingolipid regulation. We describe recent studies in Saccharomyces cerevisiae that have provided insights into how cells sense changes in sphingolipid levels in the plasma membrane and acutely regulate sphingolipid biosynthesis by altering signaling pathways. We also discuss how cellular trafficking has emerged as an important determinant of sphingolipid homeostasis. Finally, we highlight areas where work is still needed to elucidate the mechanisms of sphingolipid regulation and the physiological functions of such regulatory networks, especially in mammalian cells. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. Copyright © 2015. Published by Elsevier B.V.

  15. Peroxisomes in brain development and function☆

    PubMed Central

    Berger, Johannes; Dorninger, Fabian; Forss-Petter, Sonja; Kunze, Markus

    2016-01-01

    Peroxisomes contain numerous enzymatic activities that are important for mammalian physiology. Patients lacking either all peroxisomal functions or a single enzyme or transporter function typically develop severe neurological deficits, which originate from aberrant development of the brain, demyelination and loss of axonal integrity, neuroinflammation or other neurodegenerative processes. Whilst correlating peroxisomal properties with a compilation of pathologies observed in human patients and mouse models lacking all or individual peroxisomal functions, we discuss the importance of peroxisomal metabolites and tissue- and cell type-specific contributions to the observed brain pathologies. This enables us to deconstruct the local and systemic contribution of individual metabolic pathways to specific brain functions. We also review the recently discovered variability of pathological symptoms in cases with unexpectedly mild presentation of peroxisome biogenesis disorders. Finally, we explore the emerging evidence linking peroxisomes to more common neurological disorders such as Alzheimer’s disease, autism and amyotrophic lateral sclerosis. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. PMID:26686055

  16. Oxytocin and vasopressin modulation of the neural correlates of motivation and emotion: results from functional MRI studies in awake rats.

    PubMed

    Febo, Marcelo; Ferris, Craig F

    2014-09-11

    Oxytocin and vasopressin modulate a range of species typical behavioral functions that include social recognition, maternal-infant attachment, and modulation of memory, offensive aggression, defensive fear reactions, and reward seeking. We have employed novel functional magnetic resonance mapping techniques in awake rats to explore the roles of these neuropeptides in the maternal and non-maternal brain. Results from the functional neuroimaging studies that are summarized here have directly and indirectly confirmed and supported previous findings. Oxytocin is released within the lactating rat brain during suckling stimulation and activates specific subcortical networks in the maternal brain. Both vasopressin and oxytocin modulate brain regions involved unconditioned fear, processing of social stimuli and the expression of agonistic behaviors. Across studies there are relatively consistent brain networks associated with internal motivational drives and emotional states that are modulated by oxytocin and vasopressin. This article is part of a Special Issue entitled Oxytocin and Social Behav. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Quality in sickness certificates in a Swedish social security system perspective.

    PubMed

    Sturesson, Marine; Bylund, Sonya Hörnqvist; Edlund, Curt; Falkdal, Annie Hansen; Bernspång, Birgitta

    2015-12-01

    In Sweden, the information in the sickness certificate is crucially important for the sick-listed person as well as for the Swedish Social Insurance Agency and the sick-listed person's employer. The certificate is used as the basis for deciding whether a person is entitled to sickness benefits. Further, it communicates information significant for the return-to-work process. The aim of the study was to evaluate the quality of sickness certificates issued in primary health care and examine if the patients' or physicians' gender influences the information in the sickness certificate. An insurance specialist at the Swedish Social Insurance Agency assessed the quality of the stated information in a sample of 323 certificates issued by 146 different general practitioners at 29 different primary health care centres in northern Sweden. Thirty-four percent of the certificates did not contain sufficient information requested. The areas of the certificates in need of supplementary information were mainly the descriptions of impairment of body function and activity limitation. More certificates issued for women than certificates issued for men lacked the required information. Full-time sick leave was more often prescribed for male patients than for female. Significant differences between certificates issued for women and certificates issued for men appeared in the group of musculoskeletal diseases. No differences in quality aspects connected to physicians' gender were found. Our study indicates a need for increased knowledge about the descriptions of functioning for sick-listed persons; more cooperation between health professionals in primary health care and a better gender awareness in health care encounters. © 2015 the Nordic Societies of Public Health.

  18. Evolutionary Theory under Fire.

    ERIC Educational Resources Information Center

    Lewin, Roger

    1980-01-01

    Summarizes events of a conference on evolutionary biology in Chicago entitled: "Macroevolution." Reviews the theory of modern synthesis, a term used to explain Darwinism in terms of population biology and genetics. Issues presented at the conference are discussed in detail. (CS)

  19. Intelligent cruise control field operational test : interim report

    DOT National Transportation Integrated Search

    1997-03-01

    This interim document reports on a cooperative agreement between NHTSA and UMTRI entitled Intelligent Cruise Control (ICC) Field Operational Test (FOT). The overarching goal of the work is to characterize safety and comfort issues that are fundamenta...

  20. Cross-cultural invariance of NPI-13: Entitlement as culturally specific, leadership and grandiosity as culturally universal.

    PubMed

    Żemojtel-Piotrowska, Magdalena; Piotrowski, Jarosław; Rogoza, Radosław; Baran, Tomasz; Hitokoto, Hidefumi; Maltby, John

    2018-04-15

    The current study explores the problem with the lack of measurement invariance for the Narcissistic Personality Inventory (NPI) by addressing two issues: conceptual heterogeneity of narcissism and methodological issues related to the binary character of data. We examine the measurement invariance of the 13-item version of the NPI in three populations in Japan, Poland and the UK. Analyses revealed that leadership/authority and grandiose exhibitionism dimensions of the NPI were cross-culturally invariant, while entitlement/exploitativeness was culturally specific. Therefore, we proposed NPI-9 as indicating scalar invariance, and we examined the pattern of correlations between NPI-9 and other variables across three countries. The results suggest that NPI-9 is valid brief scale measuring general levels of narcissism in cross-cultural studies, while the NPI-13 remains suitable for research within specific countries. © 2018 International Union of Psychological Science.

  1. The GABA system in schizophrenia: cells, molecules and microcircuitry.

    PubMed

    Benes, Francine M

    2015-09-01

    This is an overview of several papers that have been published in the Special Issue of Schizophrenia Research entitled The GABA System in Schizophrenia: Cells, Molecules and Microcircuitry. This issue presents a broad range of original reports and scholarly reviews regarding recent progress in studies of neural circuitry in corticolimbic brain regions in patients with schizophrenia. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. The Quest for Equity in Higher Education: Toward New Paradigms in an Evolving Affirmative Action Era. SUNY Series, Frontiers in Education.

    ERIC Educational Resources Information Center

    Lindsay, Beverly, Ed.; Justiz, Manuel J., Ed.

    This book examines issues of the role of equity, diversity, and affirmative action in colleges and universities in the United States in light of public debates and policy changes. Part 1, entitled Setting the Stage, contains "The Landscape for Conceptual and Policy Issues" (Beverly Lindsay and Manuel J. Justiz). Part 2, Legal and…

  3. Handicapped.

    ERIC Educational Resources Information Center

    Osborne, Allan G., Jr.

    Litigation over the rights of handicapped students and employees continued at a significant level during 1989. Recovery of attorneys' fees was the most frequently litigated handicapped issue. Cases are summarized under the following topics: (1) entitlement to services; (2) procedural safeguards, including change in placement, administrative…

  4. ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Special Issue on the Role of the Library in a Digital Landscape, Number 243

    ERIC Educational Resources Information Center

    Bowen, William G.; Barrett, G. Jaia, Ed.

    2005-01-01

    This special issue of "ARL: A Bimonthly Report" contains the remarks that William G. Bowen delivered to the research library community in October 2005 at the 147th Membership Meeting of ARL. For the past 17 years Dr. Bowen has served as President of The Andrew W. Mellon Foundation. In these remarks, entitled "New Times Always; Old Time We Cannot…

  5. Intelligent cruise control field operational test. Volume I, Technical report

    DOT National Transportation Integrated Search

    1998-05-01

    This document reports on a cooperative agreement between NHTSA and UMTRI entitled Intelligent Cruise Control (ICC) Field Operational Test (FOT). The main goal of the work is to characterize safety and comfort issues that are fundamental to human inte...

  6. 78 FR 48516 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Rotations, Halts and Suspensions'' and Rule 1047A, entitled ``Trading Rotations, Halts or Reopenings'' to... trading for technical issues on Phlx. \\3\\ See Rule 1. An ``Option Exchange Official'' is an Exchange staff...

  7. Suggestopaedia-Canada. Information Letter, No. 2.

    ERIC Educational Resources Information Center

    Racle, Gabriel

    This issue consists of the following: an article entitled "Suggestopaedia and Language Teaching, International Perspective"; an article which discusses possible adaptations of the Bulgarian Suggestopaedia - A New Method of Teaching Foreign Languages"; and bibliographical notes from Canada and Bulgaria announcing new publications on…

  8. What Next in Health Policy?

    ERIC Educational Resources Information Center

    Ginzberg, Eli

    1975-01-01

    A National Health Insurance (NHI) bill is discussed. Such a law would address primarly two issues: financial coverage for catastrophic illness and some broadening of entitlements for ambulatory care. Current need, financial support, Federal and local planning and priority objectives are reviewed. (Author/EB)

  9. National Forums '89. Citizens, Leaders Look at Our Democracy. A Report on the Conference (Washington, D.C., April 16-19, 1989).

    ERIC Educational Resources Information Center

    National Issues Forums, Dayton, OH.

    This publication presents reports from National Forums '89, the culminating event of the National Issues Forums (NIF) 1988-89 cycle. A brief overview of this event is followed by a summary of the session entitled Executive Branch Conference: Reports from the Forums, in which policymakers were briefed on the outcomes of each of the 1988-89 issues.…

  10. Phosphatidylcholine and the CDP-Choline Cycle

    PubMed Central

    Fagone, Paolo; Jackowski, Suzanne

    2012-01-01

    The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Investigation of the CDP-choline pathway in yeast provides a basis for understanding the CDP-choline pathway in mammals. PtdCho is considered as an intermediate in a cycle of synthesis and degradation, and the activity of a CDP-choline cycle is linked to subcellular membrane lipid movement. The components of the mammalian CDP-choline pathway include choline transport, choline kinase, phosphocholine cytidylyltransferase, and choline phosphotransferase activities. The protein isoforms and biochemical mechanisms of regulation of the pathway enzymes are related to their cell and tissue-specific functions. Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle. Knockout mouse models define the biological functions of the CDP-choline cycle in mammalian cells and tissues. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism. PMID:23010477

  11. Cholesterol in myelin biogenesis and hypomyelinating disorders.

    PubMed

    Saher, Gesine; Stumpf, Sina Kristin

    2015-08-01

    The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function is achieved by ensheathing axons with a tightly compacted stack of membranes. Cholesterol influences myelination at many steps, from the differentiation of myelinating glial cells, over the process of myelin membrane biogenesis, to the functionality of mature myelin. Cholesterol emerged as the only integral myelin component that is essential and rate-limiting for the development of myelin in the central and peripheral nervous system. Moreover, disorders that interfere with sterol synthesis or intracellular trafficking of cholesterol and other lipids cause hypomyelination and neurodegeneration. This review summarizes recent results on the roles of cholesterol in CNS myelin biogenesis in normal development and under different pathological conditions. This article is part of a Special Issue entitled Brain Lipids. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Diffusion of molecules and macromolecules in thylakoid membranes.

    PubMed

    Kirchhoff, Helmut

    2014-04-01

    The survival and fitness of photosynthetic organisms is critically dependent on the flexible response of the photosynthetic machinery, harbored in thylakoid membranes, to environmental changes. A central element of this flexibility is the lateral diffusion of membrane components along the membrane plane. As demonstrated, almost all functions of photosynthetic energy conversion are dependent on lateral diffusion. The mobility of both small molecules (plastoquinone, xanthophylls) as well as large protein supercomplexes is very sensitive to changes in structural boundary conditions. Knowledge about the design principles that govern the mobility of photosynthetic membrane components is essential to understand the dynamic response of the photosynthetic machinery. This review summarizes our knowledge about the factors that control diffusion in thylakoid membranes and bridges structural membrane alterations to changes in mobility and function. This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Genetic incorporation of Nε-acetyllysine reveals a novel acetylation-sumoylation switch in yeast.

    PubMed

    Kim, Sang-Woo; Lee, Kyung Jin; Kim, Sinil; Kim, Jihyo; Cho, Kyukwang; Ro, Hyeon-Su; Park, Hee-Sung

    2017-11-01

    The lysine acetylation of proteins plays a key role in regulating protein functions, thereby controlling a wide range of cellular processes. Despite the prevalence and significance of lysine acetylation in eukaryotes, however, its systematic study has been challenged by the technical limitations of conventional approaches for selective lysine acetylation in vivo. Here, we report the in vivo study of lysine acetylation via the genetic incorporation of N ε -acetyllysine in yeast. We demonstrate that a newly discovered acetylation-sumoylation switch precisely controls the localization and cellular function of the yeast septin protein, Cdc11, during the cell cycle. This approach should facilitate the comprehensive in vivo study of lysine acetylation across a wide range of proteins in eukaryotic organisms. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.

    PubMed

    Howard, Rebecca J; Carnevale, Vincenzo; Delemotte, Lucie; Hellmich, Ute A; Rothberg, Brad S

    2018-04-01

    Ion translocation across biological barriers is a fundamental requirement for life. In many cases, controlling this process-for example with neuroactive drugs-demands an understanding of rapid and reversible structural changes in membrane-embedded proteins, including ion channels and transporters. Classical approaches to electrophysiology and structural biology have provided valuable insights into several such proteins over macroscopic, often discontinuous scales of space and time. Integrating these observations into meaningful mechanistic models now relies increasingly on computational methods, particularly molecular dynamics simulations, while surfacing important challenges in data management and conceptual alignment. Here, we seek to provide contemporary context, concrete examples, and a look to the future for bridging disciplinary gaps in biological ion transport. This article is part of a Special Issue entitled: Beyond the Structure-Function Horizon of Membrane Proteins edited by Ute Hellmich, Rupak Doshi and Benjamin McIlwain. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. The Role of Subjectivity: Response to Noriyuki Inoue

    ERIC Educational Resources Information Center

    Walton, Joan

    2016-01-01

    This paper offers a response to Dr. Noriyuki Inoue's article published in this issue of the "International Journal for Transformative" research, entitled "The Role of Subjectivity in Teacher Expertise Development: Mindfully Embracing the 'Black Sheep' of Educational Research." Inoue freely uses the terms…

  16. EST! environmentally sustainable transport issue paper : soft measures and transport

    DOT National Transportation Integrated Search

    2002-12-01

    The purpose of this paper was to help guide and even provoke discussion at the workshop to be held in Berlin on 5-6 December, 2002, entitled Communicating Environmentally Sustainable Transport-The roles of soft measures in achieving EST. It's easier ...

  17. Promoting Civic Literacy.

    ERIC Educational Resources Information Center

    Brown, Peggy Ann, Ed.

    1985-01-01

    Descriptions of college programs that integrate civic issues and responsibilities are provided, along with an essay entitled "Liberal Education's Civic Agenda," by Arthur Levine and David Haselkorn. The essay recommends a curriculum that emphasizes such things as basic skills and problem solving, and values and ethics. The program…

  18. Code of conduct for the International Space Station Crew. National Aeronautics and Space Administration (NASA). Interim final rule.

    PubMed

    2000-12-21

    NASA is issuing new regulations entitled "International Space Station Crew," to implement certain provisions of the International Space Station (ISS) Intergovernmental Agreement (IGA) regarding ISS crewmembers' observance of an ISS Code of Conduct.

  19. 78 FR 69927 - Notice to Manufacturers of Continuous Friction Measurement Equipment (CFME)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... Friction Measurement Equipment (CFME) AGENCY: Federal Aviation Administration (FAA), US DOT. ACTION: Notice... (FAA) is considering issuing waivers to foreign manufacturers of Continuous Friction Measurement... entitled, Continuous Friction Measurement Equipment Request for Qualifications. The FAA wants to determine...

  20. Intelligent cruise control field operational test. Vol II, Appendices A-F

    DOT National Transportation Integrated Search

    1998-05-01

    This document reports on a cooperative agreement between NHTSA and UMTRI entitled Intelligent Cruise Control (ICC) Field Operational Test (FOT). The main goal of the work is to characterize safety and comfort issues that are fundamental to human inte...

  1. From head to tail: new models and approaches in primate functional anatomy and biomechanics.

    PubMed

    Organ, Jason M; Deleon, Valerie B; Wang, Qian; Smith, Timothy D

    2010-04-01

    This special issue of The Anatomical Record (AR) is based on interest generated by a symposium at the 2008 annual meeting of the American Association of Anatomists (AAA) at Experimental Biology, entitled "An Evolutionary Perspective on Human Anatomy." The development of this volume in turn provided impetus for a Biological Anthropology Mini-Meeting, organized by members of the AAA for the 2010 Experimental Biology meeting in Anaheim, California. The research presented in these pages reflects the themes of these symposia and provides a snapshot of the current state of primate functional anatomy and biomechanics research. The 17 articles in this special issue utilize new models and/or approaches to study long-standing questions about the evolution of our closest relatives, including soft-tissue dissection and microanatomical techniques, experimental approaches to morphology, kinematic and kinetic biomechanics, high-resolution computed tomography, and Finite Element Analysis (FEA). This volume continues a close historical association between the disciplines of anatomy and biological anthropology: anatomists benefit from an understanding of the evolutionary history of our modern form, and biological anthropologists rely on anatomical principles to make informed evolutionary inferences about our closest relatives. (c) 2010 Wiley-Liss, Inc.

  2. Cognitive enhancement by omega-3 fatty acids from child-hood to old age: findings from animal and clinical studies.

    PubMed

    Luchtman, Dirk W; Song, Cai

    2013-01-01

    Omega-(n)-3 polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are major components of neuronal membranes and have a wide range of functions, from modulating synaptic plasticity and neurochemistry, to neuroimmune-modulation and neuroprotection. Thus, it is not surprising that n-3 PUFA are widely acknowledged to have cognitive-enhancing effects. Although clinical evidence is somewhat conflicting, probably in large part due to methodological issues, animal studies have consistently demonstrated that n-3 PUFA are indispensable for proper brain development, may enhance cognitive function in healthy, adult individuals and attenuate cognitive impairment in aging and age-related disorders, such as dementia. This review discusses and integrates up to date evidence from clinical and animal studies investigating the cognitive-enhancing effects of n-3 PUFA during development, child- and adult-hood, as well as old-age with associated neurodegenerative diseases, such as Alzheimer's disease. Furthermore, we cover the major underlying biochemical and neurophysiological mechanisms by which n-3 PUFA mediate these effects on cognition. This article is part of a Special Issue entitled 'Cognitive Enhancers'. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Challenges in the use of treatment to investigate cognition.

    PubMed

    Nickels, Lyndsey; Rapp, Brenda; Kohnen, Saskia

    2015-01-01

    The use of data from people with cognitive impairments to inform theories of cognition is an established methodology, particularly in the field of cognitive neuropsychology. However, it is less well known that studies that aim to improve cognitive functioning using treatment can also inform our understanding of cognition. This paper discusses a range of challenges that researchers face when testing theories of cognition and particularly when using treatment as a tool for doing so. It highlights the strengths of treatment methodology for testing causal relations and additionally discusses how generalization of treatment effects can shed light on the nature of cognitive representations and processes. These points are illustrated using examples from the Special Issue of Cognitive Neuropsychology entitled Treatment as a tool for investigating cognition.

  4. Skeletal (stromal) stem cells: an update on intracellular signaling pathways controlling osteoblast differentiation.

    PubMed

    Abdallah, Basem M; Jafari, Abbas; Zaher, Walid; Qiu, Weimin; Kassem, Moustapha

    2015-01-01

    Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Protein dynamics and enzyme catalysis: insights from simulations.

    PubMed

    McGeagh, John D; Ranaghan, Kara E; Mulholland, Adrian J

    2011-08-01

    The role of protein dynamics in enzyme catalysis is one of the most active and controversial areas in enzymology today. Some researchers claim that protein dynamics are at the heart of enzyme catalytic efficiency, while others state that dynamics make no significant contribution to catalysis. What is the biochemist - or student - to make of the ferocious arguments in this area? Protein dynamics are complex and fascinating, as molecular dynamics simulations and experiments have shown. The essential question is: do these complex motions have functional significance? In particular, how do they affect or relate to chemical reactions within enzymes, and how are chemical and conformational changes coupled together? Biomolecular simulations can analyse enzyme reactions and dynamics in atomic detail, beyond that achievable in experiments: accurate atomistic modelling has an essential part to play in clarifying these issues. This article is part of a Special Issue entitled: Protein Dynamics: Experimental and Computational Approaches. Copyright © 2010 Elsevier B.V. All rights reserved.

  6. The Broken Mirror: A Self Psychological Treatment Perspective for Relationship Violence

    PubMed Central

    Wexler, David B.

    1999-01-01

    Clinicians face formidable challenges in working with male perpetrators of domestic violence. Many treatment programs use a confrontational approach that emphasizes male entitlement and patriarchal societal attitudes, without honoring the genuine psychological pain of the abusive male. Although some men with strong psychopathic tendencies are almost impossible to treat, the majority of spouse-abusing males respond best to an empathic, client-centered, self psychological approach that also includes education about sociocultural issues and specific skill building. Understanding the deprivations in mirroring selfobject functions from which these men typically suffer facilitates clinical treatment response. While insisting that men take full responsibility for their abusive behavior, treatment approaches can still be most effective by addressing inherent psychological issues. Group leaders who can offer respect for perpetrators' history, their experience of powerlessness, and their emotional injuries in primary relationships are more likely to make an impact.(The Journal of Psychotherapy Practice and Research 1999; 8:129–141) PMID:10079460

  7. Two Studies on the Role of Business & Industry and Labor Participation in Career Education: Enhancing Business and Industry Participation in Career Education; Issues and Strategies for Enhancing the Participation of Labor in the Implementation of Career Education.

    ERIC Educational Resources Information Center

    Hensley, Gene; Schulman, Mark

    The first paper contained in this document, entitled "Enhancing Business and Industry Participation in Career Education," addresses the following topics: Interrelationships between business, industry and schools, issues in strengthening the collaboration of education and business and industry, problems and possibilities of increased interaction,…

  8. Comments on Professor Lortie's Paper Entitled "The Cracked Cake of Educational Custom and Emerging Issues in Evaluation." Center for the Study of Evaluation of Instructional Programs Occasional Report No. 21.

    ERIC Educational Resources Information Center

    Gage, N. L.

    This commentary takes no serious exception to Professor Lortie's conclusions about educational changes and issues in evaluation, but it examines certain assumptions. It questions the implications that each school district needs independent evaluation and that evaluation should be applied at the end of a given educational program, and asks what…

  9. 25 CFR 249.3 - Identification cards.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE OFF-RESERVATION TREATY FISHING... evidence that the authorized holder thereof is entitled to exercise the fishing rights secured by the... exercise of any tribal fishing right. (f) All cards issued by the Commisssioner of Indian Affairs pursuant...

  10. 25 CFR 249.3 - Identification cards.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE OFF-RESERVATION TREATY FISHING... evidence that the authorized holder thereof is entitled to exercise the fishing rights secured by the... exercise of any tribal fishing right. (f) All cards issued by the Commisssioner of Indian Affairs pursuant...

  11. The "Scholar's Anthology": Televisual Studies.

    ERIC Educational Resources Information Center

    Gronbeck, Bruce E., Ed.

    1983-01-01

    The five major articles in this journal issue focus on television criticism as an academic field. An introduction, entitled "The 'Scholar's Anthology': Televisual Studies" (Bruce Gronbeck), is followed by articles discussing the following topics: (1) the discourses of television quiz programs (John Fiske), (2) the dialectic of feminine…

  12. Opening Transportation Data for the Public Good : Getting Our Bits in a Row

    DOT National Transportation Integrated Search

    2016-09-01

    The U.S. Department of Transportation (USDOT) Public Access Plan was issued in November 2015, in response to the February 22, 2013 Office of Science and Technology Policy (OSTP) Memorandum for the Heads of Executive Departments and Agencies entitled ...

  13. Explorations in Regional Variation: A Variational Pragmatic Perspective

    ERIC Educational Resources Information Center

    Barron, Anne

    2015-01-01

    The present article introduces the Special Issue entitled "A Variational Pragmatic Approach to Regional Variation in Language," a collection of papers which celebrates the work of Klaus P. Schneider (Rheinische Friedrich-Wilhelms-Universität Bonn, Germany) on the occasion of his 60th birthday.

  14. Plan to increase public access to the results of Federally-funded scientific research results.

    DOT National Transportation Integrated Search

    2015-12-16

    This plan is issued in response to the February 22, 2013 Office of Science and Technology Policy (OSTP) Memorandum for the Heads of Executive Departments and Agencies entitled Increasing Access to the Results of Federally Funded Scientific Researc...

  15. 76 FR 6456 - Intent To Grant an Exclusive License for a U.S. Government-Owned Invention

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ..., revocable license, to U.S. Patent No. 6,254,873, issued July 3, 2001, entitled ``Inactivated Dengue Virus... against Dengue virus for human use. The intended licensee is GlaxoSmithKline Bio, with its principal place...

  16. Designing Nordic Technology-Enhanced Learning

    ERIC Educational Resources Information Center

    Cerratto-Pargman, Teresa; Jarvela, Sanna M.; Milrad, Marcelo

    2012-01-01

    The latest developments of information and communication technologies (ICT) and its large penetration in different sectors of our society pose new challenges and demands in the field of education. This special issue entitled "Designing Nordic technology-enhanced learning (TEL)", presents and discusses how researchers in the Nordic…

  17. Education of Native Americans Today.

    ERIC Educational Resources Information Center

    Triplett, DeWayne R., Ed.; Ellis, Joseph R., Ed.

    1978-01-01

    Various aspects of Indian education are treated in the two poems and 12 articles that constitute this issue of "Thresholds in Education." An article entitled "Indian Self-Determination and Indian Education" charts the growth of the self-determination movement, the influence of cultural pluralism, and the increasing involvement…

  18. Edutopia, 1993-1995.

    ERIC Educational Resources Information Center

    Edutopia, 1994

    1994-01-01

    This document consists of the first four issues of a newsletter entitled "Edutopia." The name Edutopia signifies a version of what a technology-enriched educational system of the future would look like. The newsletter is intended to facilitate the integration of interactive multimedia and telecommunications technologies with teaching and…

  19. Education Facilities for Young Children

    ERIC Educational Resources Information Center

    Meade, Anne; Ross, Fiona

    2006-01-01

    Educational buildings and grounds can provide a supportive and stimulating environment for the learning process as well as contribute to greater community needs. These issues were addressed at an international conference entitled "Making Space: Architecture and Design for Young Children". Described here are the importance of outdoor…

  20. On Critchfield's Proposal: Student Concerns and Recommendations

    ERIC Educational Resources Information Center

    Bayles, Makenzie W.; Boutain, Ariana R.; Brandt, Julie A. Ackerlund; Call, Nikki; Dracobly, Joseph D.; Greer, Brian D.; Gureghian, Danielle L.; Harper, Amy M.; Merritt, Todd A.; Miller, Jonathan R.; Payne, Steven W.; Morris, Edward K.

    2012-01-01

    An issue of "The Behavior Analyst" contained an article by Critchfield (2011), entitled "Interesting Times: Practice, Science, and Professional Associations in Behavior Analysis," about a rift between the field's scientists and practitioners. Critchfield observed that the science and practice of behavior analysis are subject to different…

  1. Severe Weather

    ERIC Educational Resources Information Center

    Forde, Evan B.

    2004-01-01

    Educating the public about safety issues related to severe weather is part of the National Oceanic and Atmospheric Administration's (NOAA) mission. This article deals with a poster entitled, "Severe Weather," that has been created by NOAA to help educate the public about hazardous weather conditions. The four types of severe weather highlighted in…

  2. 12 CFR 509.30 - Partial summary disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEDURE IN ADJUDICATORY PROCEEDINGS Uniform Rules of Practice and Procedure § 509.30 Partial summary disposition. If the administrative law judge determines that a party is entitled to summary disposition as to... on the remaining issues must be ordered. Those claims for which the administrative law judge has...

  3. FACCCTS: The Journal of the Faculty Association of California Community Colleges, 1997-1998.

    ERIC Educational Resources Information Center

    Martinez, Katherine, Ed.

    1998-01-01

    This document contains the four Faculty Association of California Community Colleges (FACCCTS) newsletters published during the 1997-98 academic year. The first issue, entitled "Realities, Myths, and Perceptions of the California Community Colleges," contains the following articles: "Myth Perceptions,""Budget Brings Great…

  4. 45 CFR 672.13 - Accelerated decision; decision to dismiss.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Section 672.13 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... genuine issue of material fact exists and a party is entitled to judgment as a matter of law regarding all... determine what material facts exist without substantial controversy and what material facts remain...

  5. 45 CFR 672.13 - Accelerated decision; decision to dismiss.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Section 672.13 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... genuine issue of material fact exists and a party is entitled to judgment as a matter of law regarding all... determine what material facts exist without substantial controversy and what material facts remain...

  6. 45 CFR 672.13 - Accelerated decision; decision to dismiss.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Section 672.13 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... genuine issue of material fact exists and a party is entitled to judgment as a matter of law regarding all... determine what material facts exist without substantial controversy and what material facts remain...

  7. 45 CFR 672.13 - Accelerated decision; decision to dismiss.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Section 672.13 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... genuine issue of material fact exists and a party is entitled to judgment as a matter of law regarding all... determine what material facts exist without substantial controversy and what material facts remain...

  8. 45 CFR 672.13 - Accelerated decision; decision to dismiss.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 672.13 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... genuine issue of material fact exists and a party is entitled to judgment as a matter of law regarding all... determine what material facts exist without substantial controversy and what material facts remain...

  9. 29 CFR 4041.31 - Notice of noncompliance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS TERMINATION... § 4041.23; (ii) The plan administrator failed to issue notices of plan benefits to all affected parties entitled to plan benefits in accordance with § 4041.24; (iii) The plan administrator failed to file the...

  10. Toward (Whose) Morality in Teacher Education?

    ERIC Educational Resources Information Center

    Milner, H. Richard; Delale-O'Connor, Lori

    2016-01-01

    Richard Milner, and Lori Delale-O'Connor offer their remarks on Daniel Lapsley & Ryan Woodbury's commentary (available in this v38 n3 2016 issue of "Action in Teacher Education") entitled "Moral Character Development for Teacher Education." They begin the conversation by commenting that Lapsley and Woodbury raise some…

  11. Sandcastle Competitions

    ERIC Educational Resources Information Center

    Baggaley, Jon

    2016-01-01

    This commentary discusses reasons that lead scholars to feel entitled to make judgements in areas where they have little or no expertise. Three current reports about the future of online learning are considered, issued by the Global Learning Council, Massachusetts Institute of Technology, and the Gates Foundation. Two of these publications contain…

  12. Suggestopaedia-Canada. Information Letter, No. 3.

    ERIC Educational Resources Information Center

    Racle, Gabriel

    This issue consists of the following: a "minilexicon" of terms directly or indirectly related to the field of suggestion and learning; the translation of an article by T. Tachev entitled "Learning Foreign Languages by Suggestion: The Unsuspected Possibilities of Human Memory"; a review of the book "An Introduction to…

  13. Youth Studies Bulletin. Vol. 3 No. 2.

    ERIC Educational Resources Information Center

    Youth Studies Bulletin, 1984

    1984-01-01

    This bulletin contains materials--announcements, papers, and studies--that are concerned with youth policy issues and that focus on education and training. The first section, entitled Quidnunc, offers brief descriptions of projects of interest, reports recent appointments, and announces conferences. The second section, called Aspects, offers two…

  14. 77 FR 14405 - Preparation for International Cooperation on Cosmetics Regulations; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ...] Preparation for International Cooperation on Cosmetics Regulations; Public Meeting AGENCY: Food and Drug... public meeting entitled ``International Cooperation on Cosmetics Regulations (ICCR)-Preparation for ICCR.... Interested persons may present data, information, or views orally or in writing, on issues pending at the...

  15. School Choice: Examining the Evidence.

    ERIC Educational Resources Information Center

    Rasell, Edith, Ed.; Rothstein, Richard, Ed.

    This book presents a summary of school-choice issues, and is organized around a 1992 seminar entitled "Choice: What Role in American Education?" Each part presents a set of conference papers, followed by discussants' remarks and excerpts from audience discussion. The introduction summarizes the papers' positions and conclusions. Participants…

  16. The Process of Designing Task Features

    ERIC Educational Resources Information Center

    Bauer, Malcolm

    2014-01-01

    Malcolm Bauer, from Education Testing Services, provides his comments on the Focus article in this issue of "Measurement" entitled : "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games" (Russell G. Almond, Yoon Jeon Kim, Gertrudes Velasquez, Valerie J. Shute). Bauer begins his remarks by noting…

  17. The plasma membrane: Penultimate regulator of ADAM sheddase function.

    PubMed

    Reiss, Karina; Bhakdi, Sucharit

    2017-11-01

    ADAM10 and ADAM17 are the best characterized members of the ADAM (A Disintegrin and Metalloproteinase) - family of transmembrane proteases. Both are involved diverse physiological and pathophysiological processes. ADAMs are known to be regulated by posttranslational mechanisms. However, emerging evidence indicates that the plasma membrane with its unique dynamic properties may additionally play an important role in controlling sheddase function. Membrane events that could contribute to regulation of ADAM-function are summarized. Surface expression of peptidolytic activity should be differentiated from ADAM-sheddase function since the latter additionally requires that the protease finds its substrate in the lipid bilayer. We propose that this is achieved through horizontal and vertical reorganization of membrane nanoarchitecture coordinately occurring at the sites of sheddase activation. Reshuffling of nanodomains thereby guides traffic of enzyme and substrate to each other. For ADAM17 phosphatidylserine exposure is required to then induce its shedding function. The novel concept that physicochemical properties of the lipid bilayer govern the action of ADAM-proteases may be extendable to other functional proteins that act at the cell surface. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John. Copyright © 2017. Published by Elsevier B.V.

  18. Intercultural Dimensions of Teaching Speech Communication in Malaysia: Negotiating the Malays' Malaise.

    ERIC Educational Resources Information Center

    Dick, Robert C.; Robinson, Brenda M.

    A study examined a cooperative international education program established between Indiana University and the government of Malaysia entitled the Institut Teknologi MARA/Midwest University Consortium for International Activities (ITM/MUCIA). It further explored the issues to be addressed in turning over the program to Malaysian faculty and…

  19. 12 CFR 308.30 - Partial summary disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PRACTICE AND PROCEDURE Uniform Rules of Practice and Procedure § 308.30 Partial summary disposition. If the administrative law judge determines that a party is entitled to summary disposition as to certain claims only, he... issues must be ordered. Those claims for which the administrative law judge has determined that summary...

  20. Parasitic Weeds, a Scientific Challenge

    USDA-ARS?s Scientific Manuscript database

    A recent issue of the SCI journal Pest Management Science (May, 2009) was devoted to an overview of the problem of parasitic weeds and to the research that is being done to alleviate it. These papers are from an OECD-sponsored conference entitled Managing Parasitic Weeds that recently brought the b...

  1. Guest Editorial

    DOE PAGES

    Deline, Christopher A; van Sark, Wilfried; Georghiou, George E.

    2017-08-16

    This Special Issue entitled 'Performance Assessment and Condition Monitoring of Photovoltaic Systems for Improved Energy Yield', contains ten papers that discuss various aspects in performance assessment, thus bringing the reader up to date with the present state-of-the-art technologies. In particular, the following topics are addressed: system performance monitoring; operational analysis and design; solar forecasting.

  2. 48 CFR 305.205 - Special situations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... situations. (a) An OPDIV may issue an advance notice, entitled “Research and Development Sources Sought,” in Federal Business Opportunities (FedBizOpps), in accordance with the requirements of FAR 5.205(a). The... requirement. The notice is not intended to solicit technical, scientific, or business information for project...

  3. 76 FR 69284 - Pure Magnesium From China

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... China Determination On the basis of the record \\1\\ developed in the subject five-year review, the United... China would be likely to lead to continuation or recurrence of material injury to an industry in the...), entitled Pure Magnesium from China: Investigation No. 731-TA-696 (Third Review). Issued: November 2, 2011...

  4. Sustainable School Capacity Building--One Step Back, Two Steps Forward?

    ERIC Educational Resources Information Center

    Dinham, Stephen; Crowther, Frank

    2011-01-01

    Purpose: This paper aims to serve as an introduction to and overview of this special issue of the "Journal of Educational Administration" entitled "Building organisational capacity in school education". The co-editors have solicited contributions from authors in Wales, Australia, Canada, the USA, England, Hong Kong and New…

  5. Interfaces. Linguistics and Psychoanalysis Newsletter, No. 6.

    ERIC Educational Resources Information Center

    Di Pietro, Robert, Ed.

    This newsletter reports on phenomena at the intersection of linguistics and psychoanalysis and psychiatry. This issue consists of the following articles: (1) an editorial entitled "Idioms, How We Love/Have You!", on the possible reasons behind the use of idioms; (2) "The Last Renaissance (Language in a Drug Rehabilitation Community)," by Harold…

  6. The Industrial Base and National Security: A New Strategy

    DTIC Science & Technology

    1993-04-01

    addresses this issue in her article entitled, " Managing Innovation on the Factory Floor": Manufacturing managers often buy the most advanced...Incentives Program." Government Contract Number MDA903-85-C-0139 Final Report, 1986. 31 11. Tyre, Marcie J. " Managing Innovation On The Factory Floor

  7. Thinking Critically about Social Issues through Visual Material

    ERIC Educational Resources Information Center

    Rawlinson, Kate; Wood, Susan Nelson; Osterman, Mark; Sullivan, Claudia Caro

    2007-01-01

    This article addresses an arts-integrated social studies curriculum for grades three through five entitled Artful Citizenship, designed by The Wolfsonian-Florida International University. Funded by the U.S. Department of Education's Arts in Education Model Development and Dissemination Grant program, the design and implementation of the program…

  8. On Campus with Women. Spring 1986 [and] Summer 1986.

    ERIC Educational Resources Information Center

    On Campus with Women, 1986

    1986-01-01

    Developments in education, employment, and the courts concerning the status of women are covered in two newsletter issues. Included is an article from "Ms. Magazine" entitled "Do SATs Shortchange Women?" News items include the following: a salary bias court case, minority women in intercollegiate athletics, athletic scholarships for women,…

  9. 77 FR 2556 - Ethical and Regulatory Challenges in the Development of Pediatric Medical Countermeasures; Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ...] Ethical and Regulatory Challenges in the Development of Pediatric Medical Countermeasures; Public Workshop... Administration (FDA), Office of Pediatric Therapeutics, is announcing a public workshop entitled ``Ethical and... provide a forum for careful consideration of scientific, ethical, and regulatory issues confronting FDA...

  10. Building a Legacy: Women in Social Education, 1784-1984. NCSS Bulletin.

    ERIC Educational Resources Information Center

    Crocco, Margaret Smith, Ed.; Davis, O. L., Jr., Ed.

    This collection of biographical articles presents several issues concerning story of women working in the social studies placing it within a broad intellectual and social context. Following the "Preface" (M. S. Crocco), the collection is divided into five chronological sections. The first section entitled, "Conceptualizing Social…

  11. Revisiting the Blind Alley of Value Added

    ERIC Educational Resources Information Center

    Banta, Trudy W.; Pike, Gary R.

    2007-01-01

    The Commission on the Future of Higher Education appointed by Secretary of Education Margaret Spellings issued a report in September 2006 entitled "A Test of Leadership: Charting the Future of U.S. Higher Education" [U.S. Department of Education, 2006(ED493504)]. Two key commission recommendations are stated: "Higher education institutions should…

  12. Districts, Local Education Authorities, and the Context of Policy Analysis

    ERIC Educational Resources Information Center

    Louis, Karen Seashore

    2013-01-01

    Purpose: The purpose of this paper is to present the author's commentary on the special issue of "Journal of Educational Administration" entitled "Systemwide Reform: Examining Districts under Pressure". Design/methodology/approach: The author gives her personal opinions, draws upon her recent experiences in the national…

  13. 75 FR 70725 - Spectrum Policy Seminar for the Utility Sector

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... Wazer, Senior Advisor, Technology Law (202) 586-3421; [email protected] . For Media Inquires you may... comment process, the Department of Energy (DOE) issued a report entitled, ``Communications Requirements of Smart Grid Technologies. '' The complete text of the report, and of a second report addressing data...

  14. Focus on Law Studies, 1990-91.

    ERIC Educational Resources Information Center

    Focus on Law Studies, 1991

    1991-01-01

    The fall 1990 issue includes essays that recapture some of the presentations and thinking of the 1990 American Bar Association annual conference on higher education, entitled "American Citizenship and the Constitution." The idea of community was a recurring theme of the conference, and is the focus of three essays included in the Fall…

  15. 78 FR 22349 - Guidance on the Treatment of Uncertainties Associated With PRA in Risk-Informed Decisionmaking

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0066] Guidance on the Treatment of Uncertainties Associated With PRA in Risk-Informed Decisionmaking AGENCY: Nuclear Regulatory Commission. ACTION... issued for public comment a document entitled: NUREG-1855, Revision 1, ``Guidance on the Treatment of...

  16. 32 CFR 651.14 - Integration with Army planning.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... be controversial. In most cases, local citizens and/or existing advisory groups should assist in... reduce or eliminate discussion of minor issues to help focus analyses. Such an approach will minimize... recommendations presented in the CEQ publication entitled “The National Environmental Policy Act: A Study of Its...

  17. 32 CFR 651.14 - Integration with Army planning.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... be controversial. In most cases, local citizens and/or existing advisory groups should assist in... reduce or eliminate discussion of minor issues to help focus analyses. Such an approach will minimize... recommendations presented in the CEQ publication entitled “The National Environmental Policy Act: A Study of Its...

  18. 32 CFR 651.14 - Integration with Army planning.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... be controversial. In most cases, local citizens and/or existing advisory groups should assist in... reduce or eliminate discussion of minor issues to help focus analyses. Such an approach will minimize... recommendations presented in the CEQ publication entitled “The National Environmental Policy Act: A Study of Its...

  19. 32 CFR 651.14 - Integration with Army planning.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... be controversial. In most cases, local citizens and/or existing advisory groups should assist in... reduce or eliminate discussion of minor issues to help focus analyses. Such an approach will minimize... recommendations presented in the CEQ publication entitled “The National Environmental Policy Act: A Study of Its...

  20. 32 CFR 651.14 - Integration with Army planning.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... be controversial. In most cases, local citizens and/or existing advisory groups should assist in... reduce or eliminate discussion of minor issues to help focus analyses. Such an approach will minimize... recommendations presented in the CEQ publication entitled “The National Environmental Policy Act: A Study of Its...

  1. Governance and Free Education: Directions, Mechanisms and Policy Tensions

    ERIC Educational Resources Information Center

    Bray, Mark

    2007-01-01

    In 2006, the Department for International Development (DfID) of the United Kingdom Government issued a White Paper entitled "Eliminating World Poverty: Making Governance Work for Poor People." The DfID document observed that good governance requires attention to State capability, described at "the extent to which leaders and…

  2. Why Academic Depth and Rigour in University-Based Coursework Matters for Prospective Teachers

    ERIC Educational Resources Information Center

    Rusznyak, Lee; Balfour, Robert; Van Vollenhoven, Willie; Sosibo, Lungi

    2016-01-01

    This special issue of "Perspectives in Education" arises from a symposium entitled "Academic depth and rigour in initial teacher education" jointly organised by four universities in South Africa. The symposium, held in October 2014, attracted 125 delegates from 18 South African higher education institutions (HEIs).…

  3. 14 CFR 406.141 - Motions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., at any time before the administrative law judge has issued an initial decision in the proceedings... that the party making the motion is entitled to a decision as a matter of law. The party making the..., including affidavits, to the motion. (c) Form and time. Except for oral motions heard on the record, a...

  4. FACCCTS: Journal of the Faculty Association of California Community Colleges, 2001-2002.

    ERIC Educational Resources Information Center

    Martinez, Katherine, Ed.

    2002-01-01

    This document is comprised of four Faculty Association of California Community Colleges (FACCC) newsletters. The September 2001 issue is entitled "Many Voices, One Goal," and contains the following articles: "Growing Pains, Faculty's Role in Governance," and "AB 1725 and Other War Stories," among others. The issue…

  5. Questioning Collectives and Agencies: A Commentary on Curricular Choices

    ERIC Educational Resources Information Center

    Arnold, Jenny

    2015-01-01

    This commentary explores theoretical alternatives for viewing the problem identified by Volny Fages and Virginie Albe in their article entitled Social issues in nanoscience and nanotechnology Master's degrees: The socio-political stakes of curricular choices. An approach to social research is suggested that would render visible the associations…

  6. PREFACE: SPECIAL ISSUE OF ATMOSPHERIC ENVIRONMENT, FOR PARTICULATE MATTER: ATMOSPHERIC SCIENCES, EXPOSURE AND THE FOURTH COLLOQUIUM ON PM AND HUMAN HEALTH

    EPA Science Inventory

    In a continuing effort to improve communications among the atmospheric sciences, policy, and health communities, an international specialty conference was initiated in 2001 that took place in April 2003 in Pittsburgh, PA. The conference entitled, "Particulate Matter: Atmospheric...

  7. Why Doesn't This Feel Empowering? The Challenges of Web-Based Intercultural Dialogue

    ERIC Educational Resources Information Center

    Bali, Maha

    2014-01-01

    Ellsworth's article entitled "Why doesn't this feel empowering? Working through the repressive myths of critical pedagogy" raises issues about the complex dynamics of implementing critical pedagogy in real classrooms, and the difficulties and paradoxes of putting the empowerment rhetoric into practice. This article analyses the…

  8. Suggestopaedia-Canada.

    ERIC Educational Resources Information Center

    Racle, Gabriel

    This issue presents an English translation and the original French version of the text of a speech delivered by Dr. Georgui Lozanov at the First International Congress of Hypnopaedia and Suggesto-hypnopaedia in Paris on May 29-30, 1976. The paper is entitled "A General Theory of Suggestion in the Communications Process and the Activation of…

  9. Reaching Black Men. Commentary

    ERIC Educational Resources Information Center

    Gassman, Marybeth

    2010-01-01

    Journalist Elizabeth Redden brings to the surface several salient issues in her article entitled, "Reaching Black Men." First, she illuminates that fact that access is not enough when it comes to educating African American men. Second, she points to the importance of having campus-wide initiatives to support the success of Black men. And…

  10. 15 CFR 200.112 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Reports. 200.112 Section 200.112... FEES § 200.112 Reports. (a) Results of calibrations and other tests are issued to the customer as formal reports entitled, “National Institute of Standards & Technology Report of Calibration,” “National...

  11. 15 CFR 200.112 - Reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Reports. 200.112 Section 200.112... FEES § 200.112 Reports. (a) Results of calibrations and other tests are issued to the customer as formal reports entitled, “National Institute of Standards & Technology Report of Calibration,” “National...

  12. 15 CFR 200.112 - Reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Reports. 200.112 Section 200.112... FEES § 200.112 Reports. (a) Results of calibrations and other tests are issued to the customer as formal reports entitled, “National Institute of Standards & Technology Report of Calibration,” “National...

  13. 78 FR 36698 - Microbiology Devices; Reclassification of Nucleic Acid-Based Systems for Mycobacterium tuberculosis

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... specimens from class III (premarket approval) into class II (special controls). FDA is also issuing the draft special controls guideline entitled ``Class II Special Controls Guideline: Nucleic Acid-Based In... regulatory controls needed to provide reasonable assurance of their safety and effectiveness. The three...

  14. Doing School Choice Right: Preliminary Findings

    ERIC Educational Resources Information Center

    Harvey, James; Hill, Paul T.

    2006-01-01

    The Center on Reinventing Public Education (CRPE) has launched a new initiative entitled "Doing School Choice Right." Funded by the Bill and Melinda Gates, Annie E. Casey, and Lynde and Harry Bradley Foundations, the initiative's goal is to help state and local leaders handle practical issues whose resolution can determine whether school…

  15. Mother/Child, Father/Child Relationships.

    ERIC Educational Resources Information Center

    Stevens, Joseph H., Jr., Ed.; Mathews, Marilyn, Ed.

    This collection of papers on parent-child relationships consists of three research reports, six research reviews and two position papers on issues critical to research and practice. Papers included were selected on the basis of their relevance to the work of practitioners who counsel parents. The volume's four thematic sections are entitled: (1)…

  16. 76 FR 55108 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ...Notice is hereby given that the U.S. International Trade Commission has received a complaint entitled In Re Certain Devices for Mobile Data Communication, DN 2843; the Commission is soliciting comments on any public interest issues raised by the complaint.

  17. 78 FR 70354 - Conceptual Example of a Proposed Risk Management Regulatory Framework Policy Statement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0254] Conceptual Example of a Proposed Risk Management... issuing a document entitled: ``White Paper on a Conceptual Example of a Proposed Risk Management... ``openness,'' a white paper on a Conceptual Example of a Proposed Risk Management Regulatory Framework (RMRF...

  18. 78 FR 61873 - Revisions to the Export Administration Regulations (EAR) To Make the Commerce Control List (CCL...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-04

    ...This final rule implements changes that were proposed on November 29, 2012 in a proposed rule entitled Revisions to the Export Administration Regulations (EAR) To Make the Commerce Control List (CCL) Clearer. The changes in the November 29 proposed rule were informed by public comments received in response to an advance notice of proposed rulemaking entitled Commerce Control List: Revising Descriptions of Items and Foreign Availability published as part of the President's Export Control Reform (ECR) Initiative on December 9, 2010. This final rule implements changes that can be made to the CCL without requiring changes to multilateral export control regime guidelines or lists. This final rule also makes conforming changes and minor clarifications as a result of the publication of two final rules implementing the Export Control Reform Initiative: the April 16, 2013 final rule entitled Revisions to the Export Administration Regulations: Initial Implementation of Export Control Reform; and the July 8, 2013 final rule entitled Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War; Submersible Vessels, Oceanographic Equipment; Related Items; and Auxiliary and Miscellaneous Items that the President Determines No Longer Warrant Control under the United States Munitions List. Lastly, this final rule is making revisions to the EAR as a result of public comments received in response to the November 29 proposed rule and to a notice of inquiry (NOI) entitled Request for Public Comments on Shipping Tolerances for Export Licenses Issued by the Bureau of Industry and Security (BIS), that BIS published on July 5, 2012.

  19. Importance of cochlear health for implant function.

    PubMed

    Pfingst, Bryan E; Zhou, Ning; Colesa, Deborah J; Watts, Melissa M; Strahl, Stefan B; Garadat, Soha N; Schvartz-Leyzac, Kara C; Budenz, Cameron L; Raphael, Yehoash; Zwolan, Teresa A

    2015-04-01

    Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled . Copyright © 2014 Elsevier B.V. All rights reserved.

  20. How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?

    PubMed

    Besson, Pierre; Driffort, Virginie; Bon, Émeline; Gradek, Frédéric; Chevalier, Stéphan; Roger, Sébastien

    2015-10-01

    Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal isoforms, while they are not expressed, or only at a low level, in the matching normal tissue. The level of their expression and their activity is related to the aggressiveness of the disease and to the formation of metastases. A vast knowledge on the regulation of their expression and functioning has been accumulated in normal excitable cells. This helped understand their regulation in cancer cells. However, how voltage-gated sodium channels impose a pro-metastatic behavior to cancer cells is much less documented. This aspect will be addressed in the review. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Cytokine mediated tissue fibrosis☆

    PubMed Central

    Borthwick, Lee A.; Wynn, Thomas A.; Fisher, Andrew J.

    2013-01-01

    Acute inflammation is a recognised part of normal wound healing. However, when inflammation fails to resolve and a chronic inflammatory response is established this process can become dysregulated resulting in pathological wound repair, accumulation of permanent fibrotic scar tissue at the site of injury and the failure to return the tissue to normal function. Fibrosis can affect any organ including the lung, skin, heart, kidney and liver and it is estimated that 45% of deaths in the western world can now be attributed to diseases where fibrosis plays a major aetiological role. In this review we examine the evidence that cytokines play a vital role in the acute and chronic inflammatory responses that drive fibrosis in injured tissues. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease. PMID:23046809

  2. Do outcomes differ between work and non-work-related injury in a universal injury compensation system? Findings from the New Zealand Prospective Outcomes of Injury Study

    PubMed Central

    2013-01-01

    Background Poorer recovery outcomes for workers injured in a work setting, as opposed to a non-work setting, are commonly attributed to differences in financial gain via entitlement to compensation by injury setting (ie. workers compensation schemes). To date, this attribution hasn’t been tested in a situation where both work and non-work-related injuries have an equivalent entitlement to compensation. This study tests the hypothesis that there will be no differences in recovery outcomes for workers by injury setting (work and non-work) within a single universal entitlement injury compensation scheme. Methods Workforce active participants from the Prospective Outcomes of Injury Study (POIS) cohort were followed up at 3- and 12-months following injury. Participants who were injured in the period June 2007- May 2009 were recruited from New Zealand’s universal entitlement injury compensation scheme managed by the Accident Compensation Corporation (ACC). An analysis of ten vocational, disability, functional and psychological recovery outcomes was undertaken by injury setting. Modified Poisson regression analyses were undertaken to examine the relationship between injury setting and recovery outcomes. Results Of 2092 eligible participants, 741 (35%) had sustained an injury in a work setting. At 3 months, workers with work-related injuries had an elevated risk of work absence however, this difference disappeared after controlling for confounding variables (adjusted RR 1.10, 95% CI 0.94-1.29). By 12 months, workers with work-related injuries had poorer recovery outcomes with a higher risk of absence from work (aRR 1.37, 95% CI 1.10-1.70), mobility-related functional problems (aRR 1.35, 95% CI 1.14-1.60), disability (aRR 1.32, 95% CI 1.04-1.68) and impaired functioning related to anxiety/depression (aRR 1.21, 95% CI 1.00-1.46). Conclusion Our study, comparing recovery outcomes for workers by injury setting within a single universal entitlement injury compensation scheme, found mixed support for the hypothesis tested. After adjustment for possible covariates recovery outcomes did not differ by injury setting at 3 months following injury, however, by 12 months vocational, disability and some functional outcomes, were poorer for workers with work-related injuries. Given our findings, and other potential mechanisms for poorer outcomes for workers with work-related injuries, further research beyond differences in entitlement to compensation should be undertaken to inform future interventions. PMID:24148609

  3. Publisher's Note to “The association between kinematic risky driving among parents and their teenage children: Moderation by Shared Personality Characteristics”.

    PubMed

    2014-06-01

    The Publisher would like to inform readers that the article entitled "The association between kinematic risky driving among parents and their teenage children: Moderation by Shared Personality Characteristics" by Johnathon P. Ehsani, Bruce Simons-Morton, Yunlong Xie,Sheila G. Klauer, and Paul S. Albert has been removed from this issue, as it had been incorrectly included here rather than in the special issue for which it was intended. The article will be published in the correct issue in the near future. This is to ensure the continuity of the special issue is not lost. The Publisher would like to apologize for any inconvenience caused.

  4. Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Annesley, Thomas M.; Cooks, Robert G.; Herold, David A.

    Each year the journal Clinical Chemistry publishes a January special issue on a topic that is relevant to the laboratory medicine community. In January 2016 the topic is mass spectrometry, and the issue is entitled “Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine”. One popular feature in our issues is a Q&A on a topic, clearly in this case mass spectrometry. The journal is assembling a panel of 5-6 experts from various areas of mass spectrometry ranging from instrument manufacturing to practicing clinical chemists. Dick Smith is one of the scientist requested to participate in this special issue Q&A onmore » Mass Spectrometry. The Q&A Transcript is attached« less

  5. pH sensing by lipids in membranes: The fundamentals of pH-driven migration, polarization and deformations of lipid bilayer assemblies.

    PubMed

    Angelova, Miglena I; Bitbol, Anne-Florence; Seigneuret, Michel; Staneva, Galya; Kodama, Atsuji; Sakuma, Yuka; Kawakatsu, Toshihiro; Imai, Masayuki; Puff, Nicolas

    2018-03-06

    Most biological molecules contain acido-basic groups that modulate their structure and interactions. A consequence is that pH gradients, local heterogeneities and dynamic variations are used by cells and organisms to drive or regulate specific biological functions including energetic metabolism, vesicular traffic, migration and spatial patterning of tissues in development. While the direct or regulatory role of pH in protein function is well documented, the role of hydrogen and hydroxyl ions in modulating the properties of lipid assemblies such as bilayer membranes is only beginning to be understood. Here, we review approaches using artificial lipid vesicles that have been instrumental in providing an understanding of the influence of pH gradients and local variations on membrane vectorial motional processes: migration, membrane curvature effects promoting global or local deformations, crowding generation by segregative polarization processes. In the case of pH induced local deformations, an extensive theoretical framework is given and an application to a specific biological issue, namely the structure and stability of mitochondrial cristae, is described. This article is part of a Special Issue entitled: Emergence of Complex Behavior in Biomembranes edited by Marjorie Longo. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. "Pleiades Visions" for organ solo: A composition supported by documented research

    NASA Astrophysics Data System (ADS)

    Whitehouse, Matthew Robert

    Pleiades Visions is a three-movement work for organ solo inspired by indigenous music and mythology associated with the Pleiades (Seven Sisters) star cluster. Three cultural groups are represented in Pleiades Visions. The first movement, entitled "Uluru," draws from Australian Aboriginal music and mythology. The second movement, entitled "...life on other worlds," is based loosely on a Quechan (Yuman) Indian song. The concluding movement, entitled "Mauna Kea," is inspired by the opening lines of the Kumulipo, a creation chant of the Native Hawaiian culture. The source material for Pleiades Visions was identified through research incorporating techniques from the fields of cultural astronomy and ethnomusicology. This research represents a new line of inquiry for both fields. This document situates Pleiades Visions in the context of the organ literature, and suggests that Pleiades Visions might be the first organ work with a cultural astronomy inspiration. It also describes the research undergirding Pleiades Visions, demonstrates the manner in which that research informed the composition of the work, and addresses issues surrounding the use of indigenous source material in a culturally sensitive manner.

  7. New intracellular activities of matrix metalloproteinases shine in the moonlight.

    PubMed

    Jobin, Parker G; Butler, Georgina S; Overall, Christopher M

    2017-11-01

    Adaption of a single protein to perform multiple independent functions facilitates functional plasticity of the proteome allowing a limited number of protein-coding genes to perform a multitude of cellular processes. Multifunctionality is achievable by post-translational modifications and by modulating subcellular localization. Matrix metalloproteinases (MMPs), classically viewed as degraders of the extracellular matrix (ECM) responsible for matrix protein turnover, are more recently recognized as regulators of a range of extracellular bioactive molecules including chemokines, cytokines, and their binders. However, growing evidence has convincingly identified select MMPs in intracellular compartments with unexpected physiological and pathological roles. Intracellular MMPs have both proteolytic and non-proteolytic functions, including signal transduction and transcription factor activity thereby challenging their traditional designation as extracellular proteases. This review highlights current knowledge of subcellular location and activity of these "moonlighting" MMPs. Intracellular roles herald a new era of MMP research, rejuvenating interest in targeting these proteases in therapeutic strategies. This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. G-quadruplex dynamics.

    PubMed

    Harkness, Robert W; Mittermaier, Anthony K

    2017-11-01

    G-quadruplexes (GQs) are four-stranded nucleic acid secondary structures formed by guanosine (G)-rich DNA and RNA sequences. It is becoming increasingly clear that cellular processes including gene expression and mRNA translation are regulated by GQs. GQ structures have been extensively characterized, however little attention to date has been paid to their conformational dynamics, despite the fact that many biological GQ sequences populate multiple structures of similar free energies, leading to an ensemble of exchanging conformations. The impact of these dynamics on biological function is currently not well understood. Recently, structural dynamics have been demonstrated to entropically stabilize GQ ensembles, potentially modulating gene expression. Transient, low-populated states in GQ ensembles may additionally regulate nucleic acid interactions and function. This review will underscore the interplay of GQ dynamics and biological function, focusing on several dynamic processes for biological GQs and the characterization of GQ dynamics by nuclear magnetic resonance (NMR) spectroscopy in conjunction with other biophysical techniques. This article is part of a Special Issue entitled: Biophysics in Canada, edited by Lewis Kay, John Baenziger, Albert Berghuis and Peter Tieleman. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.

    PubMed

    Woods, Simone J; Hannan, Katherine M; Pearson, Richard B; Hannan, Ross D

    2015-07-01

    Recent studies have highlighted the fundamental role that key oncogenes such as MYC, RAS and PI3K occupy in driving RNA Polymerase I transcription in the nucleolus. In addition to maintaining essential levels of protein synthesis, hyperactivated ribosome biogenesis and nucleolar function plays a central role in suppressing p53 activation in response to oncogenic stress. Consequently, disruption of ribosome biogenesis by agents such as the small molecule inhibitor of RNA Polymerase I transcription, CX-5461, has shown unexpected, potent, and selective effects in killing tumour cells via disruption of nucleolar function leading to activation of p53, independent of DNA damage. This review will explore the mechanism of DNA damage-independent activation of p53 via the nucleolar surveillance pathway and how this can be utilised to design novel cancer therapies. Non-genotoxic targeting of nucleolar function may provide a new paradigm for treatment of a broad range of oncogene-driven malignancies with improved therapeutic windows. This article is part of a Special Issue entitled: Translation and Cancer. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Applications of solid-state NMR to membrane proteins.

    PubMed

    Ladizhansky, Vladimir

    2017-11-01

    Membrane proteins mediate flow of molecules, signals, and energy between cells and intracellular compartments. Understanding membrane protein function requires a detailed understanding of the structural and dynamic properties involved. Lipid bilayers provide a native-like environment for structure-function investigations of membrane proteins. In this review we give a general discourse on the recent progress in the field of solid-state NMR of membrane proteins. Solid-state NMR is a variation of NMR spectroscopy that is applicable to molecular systems with restricted mobility, such as high molecular weight proteins and protein complexes, supramolecular assemblies, or membrane proteins in a phospholipid environment. We highlight recent advances in applications of solid-state NMR to membrane proteins, specifically focusing on the recent developments in the field of Dynamic Nuclear Polarization, proton detection, and solid-state NMR applications in situ (in cell membranes). This article is part of a Special Issue entitled: Biophysics in Canada, edited by Lewis Kay, John Baenziger, Albert Berghuis and Peter Tieleman. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders.

    PubMed

    Kang, Jaeseung; Park, Haram; Kim, Eunjoon

    2016-01-01

    IRSp53 (also known as BAIAP2) is a multi-domain scaffolding and adaptor protein that has been implicated in the regulation of membrane and actin dynamics at subcellular structures, including filopodia and lamellipodia. Accumulating evidence indicates that IRSp53 is an abundant component of the postsynaptic density at excitatory synapses and an important regulator of actin-rich dendritic spines. In addition, IRSp53 has been implicated in diverse psychiatric disorders, including autism spectrum disorders, schizophrenia, and attention deficit/hyperactivity disorder. Mice lacking IRSp53 display enhanced NMDA (N-methyl-d-aspartate) receptor function accompanied by social and cognitive deficits, which are reversed by pharmacological suppression of NMDA receptor function. These results suggest the hypothesis that defective actin/membrane modulation in IRSp53-deficient dendritic spines may lead to social and cognitive deficits through NMDA receptor dysfunction. This article is part of the Special Issue entitled 'Synaptopathy--from Biology to Therapy'. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Tertiary and quaternary effects in the allosteric regulation of animal hemoglobins.

    PubMed

    Ronda, Luca; Bruno, Stefano; Bettati, Stefano

    2013-09-01

    In the last decade, protein allostery has experienced a major resurgence, boosted by the extension of the concept to systems of increasing complexity and by its exploitation for the development of drugs. Expansion of the field into new directions has not diminished the key role of hemoglobin as a test molecule for theory and experimental validation of allosteric models. Indeed, the diffusion of hemoglobins in all kingdoms of life and the variety of functions and of quaternary assemblies based on a common tertiary fold indicate that this superfamily of proteins is ideally suited for investigating the physical and molecular basis of allostery and firmly maintains its role as a main player in the field. This review is an attempt to briefly recollect common and different strategies adopted by metazoan hemoglobins, from monomeric molecules to giant complexes, exploiting homotropic and heterotropic allostery to increase their functional dynamic range. This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.

    PubMed

    Bedada, Fikru B; Wheelwright, Matthew; Metzger, Joseph M

    2016-07-01

    Human heart failure due to myocardial infarction is a major health concern. The paucity of organs for transplantation limits curative approaches for the diseased and failing adult heart. Human induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs) have the potential to provide a long-term, viable, regenerative-medicine alternative. Significant progress has been made with regard to efficient cardiac myocyte generation from hiPSCs. However, directing hiPSC-CMs to acquire the physiological structure, gene expression profile and function akin to mature cardiac tissue remains a major obstacle. Thus, hiPSC-CMs have several hurdles to overcome before they find their way into translational medicine. In this review, we address the progress that has been made, the void in knowledge and the challenges that remain. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  14. Rethinking cognition and behavior in the new classification for childhood epilepsy: Examples from frontal lobe and temporal lobe epilepsies.

    PubMed

    Smith, Mary Lou

    2016-11-01

    The new approach to classification of the epilepsies emphasizes the role of dysfunction in networks in defining types of epilepsies. This paper reviews the structural and neuropsychological deficits in two types of childhood epilepsy: frontal lobe and temporal lobe epilepsy. The evidence for and against a pattern of specificity of deficits in executive function and memory associated with these two types of epilepsies is presented. The evidence varies with the methodologies used in the studies, but direct comparison of the two types of epilepsies does not suggest a clear-cut mapping of function onto structure. These findings are discussed in light of the concept of network dysfunction. The evidence supports the conceptualization of epilepsy as a network disease. Implications for future work in the neuropsychology of pediatric epilepsy are suggested. This article is part of a Special Issue entitled "The new approach to classification: Rethinking cognition and behavior in epilepsy". Copyright © 2016 Elsevier Inc. All rights reserved.

  15. ER-plasma membrane junctions: Why and how do we study them?

    PubMed

    Chang, Chi-Lun; Chen, Yu-Ju; Liou, Jen

    2017-09-01

    Endoplasmic reticulum (ER)-plasma membrane (PM) junctions are membrane microdomains important for communication between the ER and the PM. ER-PM junctions were first reported in muscle cells in 1957, but mostly ignored in non-excitable cells due to their scarcity and lack of functional significance. In 2005, the discovery of stromal interaction molecule 1 (STIM1) mediating a universal Ca 2+ feedback mechanism at ER-PM junctions in mammalian cells led to a resurgence of research interests toward ER-PM junctions. In the past decade, several major advancements have been made in this emerging topic in cell biology, including the generation of tools for labeling ER-PM junctions and the unraveling of mechanisms underlying regulation and functions of ER-PM junctions. This review summarizes early studies, recently developed tools, and current advances in the characterization and understanding of ER-PM junctions. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Youth Apprenticeship: A School-to-Work Transition Program. Hot Topic.

    ERIC Educational Resources Information Center

    North Carolina Univ., Greensboro. School of Education.

    SERVE offers a series of publications entitled "Hot Topics," research-based documents which focus on relevant issues of the day that are important in the region. This document, the first in a series of publications, is a practical guidebook to designing and developing youth apprenticeship programs to prepare noncollege-bound high school…

  17. 14 CFR 21.21 - Issue of type certificate: normal, utility, acrobatic, commuter, and transport category aircraft...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...; aircraft engines; propellers. 21.21 Section 21.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION...; manned free balloons; special classes of aircraft; aircraft engines; propellers. An applicant is entitled... category, or for a manned free balloon, special class of aircraft, or an aircraft engine or propeller, if...

  18. 14 CFR 21.21 - Issue of type certificate: normal, utility, acrobatic, commuter, and transport category aircraft...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...; aircraft engines; propellers. 21.21 Section 21.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION...; manned free balloons; special classes of aircraft; aircraft engines; propellers. An applicant is entitled... category, or for a manned free balloon, special class of aircraft, or an aircraft engine or propeller, if...

  19. 14 CFR 21.21 - Issue of type certificate: normal, utility, acrobatic, commuter, and transport category aircraft...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...; aircraft engines; propellers. 21.21 Section 21.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION...; manned free balloons; special classes of aircraft; aircraft engines; propellers. An applicant is entitled... category, or for a manned free balloon, special class of aircraft, or an aircraft engine or propeller, if...

  20. A Brief Note on Evidence-Centered Design as a Mechanism for Assessment Development and Evaluation

    ERIC Educational Resources Information Center

    Bond, Lloyd

    2014-01-01

    Lloyd Bond comments here on the Focus article in this issue of "Measurement: Interdisciplinary Research and Perspectives". The Focus article is entitled: "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games" (Russell G. Almond, Yoon Jeon Kim, Gertrudes Velasquez, and Valerie J. Shute). Bond…

  1. Errors and Allegations about Research on Homework

    ERIC Educational Resources Information Center

    Marzano, Robert J.; Pickering, Debra J.

    2007-01-01

    This article provides a response to Kohn's article entitled "Abusing Research: The Study of Homework and Other Examples" that appeared in the September 2006 issue of the "Kappan." There Kohn asserted that many of those who conduct research on homework and report on that research misrepresent research findings. He specifically mentioned a set of…

  2. The Changed/Changing Educational Scene: The State of the Art.

    ERIC Educational Resources Information Center

    Bunke, Clinton R.; And Others

    A special attempt was made to organize this document in terms of the requirements of its readership (members of the Commission on Children, White House Conference, 1980). To this end, the first section, entitled "Gaining Perspective," provides an overview of developments, expectations, issues, dynamics, culture shock, and future trends in…

  3. A Winning Combination: An Alcohol, Other Drug, and Traffic Safety Handbook for College Campuses.

    ERIC Educational Resources Information Center

    Anderson, David, Ed.

    This manual addresses the social and legal issues facing college administrators today in dealing with alcohol and other drug problems. It is a guide for colleges and universities to develop individualized alcohol, drug, and traffic safety programs. The first part, entitled "Insights," presents background articles by professionals in higher…

  4. Aging Parents & Dilemmas of Their Children.

    ERIC Educational Resources Information Center

    Smith, Bert Kruger; And Others

    After an opening series of vignettes which describe the frustrations of adults who care for aging and infirm parents, this pamphlet addresses the issue of aging parents and the dilemmas they pose for their children. In particular, it describes a model entitled "As Parents Grow Older" (APGO) that originated as a service for families of…

  5. Diversity in the Middle: Broadening Perspectives on Intermediary Levels of School System Improvement

    ERIC Educational Resources Information Center

    Anderson, Stephen E.

    2013-01-01

    Purpose: The purpose of this paper is to present the author's commentary on the special issue of "Journal of Educational Administration" entitled "Systemwide Reform: Examining Districts under Pressure". Design/methodology/approach: The major thesis of this commentary and reflection on the preceding papers is that there is…

  6. 12 CFR 960.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... LETTERS OF CREDIT § 960.1 Definitions. As used in this part: Applicant means a person or entity at whose request or for whose account a standby letter of credit is issued. Beneficiary means a person or entity who, under the terms of a standby letter of credit, is entitled to have its complying presentation...

  7. Food and My World: My Health My World.

    ERIC Educational Resources Information Center

    Tharp, Barbara; Dresden, Judith; Denk, James; Moreno, Nancy

    This curriculum guide for students in grades K-4 is part of the My Health My World Series. It explores environmental issues, focusing on food and the environment. The unit includes (1) an activities guide for teachers entitled, "Food and My World," which presents activity-based lessons that entice students to discover concepts in…

  8. 39 CFR 960.12 - When an application may be filed.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... before the Board of Contract Appeals, the Board of Contract Appeals decision on quantum. When the Board decides only entitlement and remands the issue of quantum to the parties, the final disposition occurs when the parties execute an agreement on quantum, or if the parties cannot agree on quantum and...

  9. 39 CFR 960.12 - When an application may be filed.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... before the Board of Contract Appeals, the Board of Contract Appeals decision on quantum. When the Board decides only entitlement and remands the issue of quantum to the parties, the final disposition occurs when the parties execute an agreement on quantum, or if the parties cannot agree on quantum and...

  10. 39 CFR 960.12 - When an application may be filed.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... before the Board of Contract Appeals, the Board of Contract Appeals decision on quantum. When the Board decides only entitlement and remands the issue of quantum to the parties, the final disposition occurs when the parties execute an agreement on quantum, or if the parties cannot agree on quantum and...

  11. 39 CFR 960.12 - When an application may be filed.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... before the Board of Contract Appeals, the Board of Contract Appeals decision on quantum. When the Board decides only entitlement and remands the issue of quantum to the parties, the final disposition occurs when the parties execute an agreement on quantum, or if the parties cannot agree on quantum and...

  12. Council of Europe News-Letter 4/72.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Documentation Center for Education in Europe.

    Excerpts from "Teacher Education and Training" (the James' Report), issued in the United Kingdom early in 1972, comprise the bulk of this newsletter. James recommends that "all teachers should be entitled to release with pay for inservice education and training on a scale not less than the equivalent of one term in every seven…

  13. Indigenous African Knowledge Systems and Innovation in Higher Education in South Africa

    ERIC Educational Resources Information Center

    Higgs, P.; Higgs, L. G.; Venter, E.

    2003-01-01

    The importance of innovation in higher education is recognised in South African educational discourse. The South African White Paper on Science and Technology, issued in September 1996 and entitled, "Preparing for the 21st Century", states that, "the White Paper is built upon the twin concepts of "innovation" and a…

  14. Religious Education in Greece: A New Curriculum, an Old Issue

    ERIC Educational Resources Information Center

    Koukounaras Liagkis, Marios

    2015-01-01

    Religious Education (RE) in Greece is a compulsory school subject according the 2011 new framework for compulsory education, entitled "New School". This article focuses on two statutory documents for RE, "The Curriculum for RE" and the "The Teacher's Guide for RE", and the pilot scheme of the new curriculum running in…

  15. ACHP | News | ACHP Issue Spotlight: Transmission Lines in the West

    Science.gov Websites

    Search skip specific nav links Home arrow News arrow ACHP Announces GAO Report Calling for Improved Data on Historic Properties ACHP Announces GAO Report Calling for Improved Data on Historic Properties The U.S. Government Accountability Office (GAO) recently released a report entitled "Improved Data

  16. The next Stages in Researching Water Fluoridation: Evaluation and Surveillance

    ERIC Educational Resources Information Center

    Downer, Martin C.; Blinkhorn, Anthony S.

    2007-01-01

    Objective: (1) to provide a commentary on a conference held at the University of Manchester entitled Researching Water Fluoridation: Evaluation and Surveillance; (2) to synthesize from the proceedings of the meeting suggestions for future research and public health surveillance. Method: The main points and problematic issues raised by the speakers…

  17. 76 FR 40744 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... entitled In Re Electronic Digital Media Devices and Components Thereof, DN 2827; the Commission is soliciting comments on any public interest issues raised by the complaint. FOR FURTHER INFORMATION CONTACT... Commission, 500 E Street, SW., Washington, DC 20436, telephone (202) 205-2000. General information concerning...

  18. 41 CFR 102-79.90 - What criteria must Executive agencies consider when evaluating antenna siting requests?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... radiofrequency exposure, ET Docket No. 93-62, entitled “Guidelines for Evaluating the Environmental Effects of Radiofrequency Radiation,” issued August 1, 1996, and any other order on reconsideration relating to radiofrequency guidelines and their enforcement. These are updated guidelines for meeting health concerns that...

  19. 76 FR 67688 - Notice of Preliminary Determination of Sales at Less Than Fair Value, Postponement of Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... investigation on April 19, 2011 (see Initiation of Antidumping Duty Investigations: Bottom Mount Combination..., Electrolux requested that it be treated as a mandatory respondent in this investigation. On May 18, 2011, we... this investigation and issued a questionnaire to Electrolux. See Memorandum entitled ``Inclusion of...

  20. 75 FR 80798 - Availability for Exclusive, Non-Exclusive, or Partially-Exclusive Licensing of Inventions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... Partially-Exclusive Licensing of Inventions Concerning an Inactivated Dengue Virus Vaccine and a Method and Kit for Detection of Dengue Virus AGENCY: Department of the Army, DoD. ACTION: Notice. SUMMARY... which issued July 3, 2001, entitled ``Inactivated Dengue Virus Vaccine,'' and U.S. Patent 6,190,859...

  1. Custody and Access Issues in Schools. Law Matters.

    ERIC Educational Resources Information Center

    Hoffer, Marion

    2002-01-01

    In cases of marital separation, educators should determine a person's entitlement to a child before giving out information about the child. Courts may have denied a parent access to a child or, in the case of domestic violence, criminal charges may be involved. Educators should avoid giving evidence, but should cooperate with court-appointed…

  2. 22 CFR 42.42 - Petitions for immediate relative or preference status.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Petitions for immediate relative or preference status. 42.42 Section 42.42 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF... may not issue a visa to an alien as an immediate relative entitled to status under 201(b), a family...

  3. 22 CFR 42.42 - Petitions for immediate relative or preference status.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Petitions for immediate relative or preference status. 42.42 Section 42.42 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF... may not issue a visa to an alien as an immediate relative entitled to status under 201(b), a family...

  4. 22 CFR 42.42 - Petitions for immediate relative or preference status.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Petitions for immediate relative or preference status. 42.42 Section 42.42 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF... may not issue a visa to an alien as an immediate relative entitled to status under 201(b), a family...

  5. 22 CFR 42.42 - Petitions for immediate relative or preference status.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Petitions for immediate relative or preference status. 42.42 Section 42.42 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF... may not issue a visa to an alien as an immediate relative entitled to status under 201(b), a family...

  6. 22 CFR 42.42 - Petitions for immediate relative or preference status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Petitions for immediate relative or preference status. 42.42 Section 42.42 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF... may not issue a visa to an alien as an immediate relative entitled to status under 201(b), a family...

  7. Video Recording and the Research Process

    ERIC Educational Resources Information Center

    Leung, Constant; Hawkins, Margaret R.

    2011-01-01

    This is a two-part discussion. Part 1 is entitled "English Language Learning in Subject Lessons", and Part 2 is titled "Video as a Research Tool/Counterpoint". Working with different research concerns, the authors attempt to draw attention to a set of methodological and theoretical issues that have emerged in the research process using video data.…

  8. 39 CFR 960.12 - When an application may be filed.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... before the Board of Contract Appeals, the Board of Contract Appeals decision on quantum. When the Board decides only entitlement and remands the issue of quantum to the parties, the final disposition occurs when the parties execute an agreement on quantum, or if the parties cannot agree on quantum and...

  9. 78 FR 46969 - Human Immunodeficiency Virus Patient-Focused Drug Development and Human Immunodeficiency Virus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... for the notice of public meeting entitled ``Human Immunodeficiency Virus (HIV) Patient-Focused Drug Development and HIV Cure Research,'' published in the Federal Register of May 21, 2013 (78 FR 29755). In that... HIV, symptoms experienced because of HIV or its treatment, and issues related to HIV cure research...

  10. 75 FR 21632 - Draft Guidance for Industry and Food and Drug Administration Staff; Total Product Life Cycle...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...] Draft Guidance for Industry and Food and Drug Administration Staff; Total Product Life Cycle: Infusion... the draft guidance document entitled ``Total Product Life Cycle: Infusion Pump--Premarket Notification... this issue of the Federal Register, FDA is announcing a public meeting regarding external infusion...

  11. 31 CFR 501.727 - Motion for summary disposition.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...). (b) Decision on motion. The Administrative Law Judge may promptly decide the motion for summary disposition or may defer decision on the motion. The Administrative Law Judge shall issue an order granting a... fact and the party making the motion is entitled to a summary disposition as a matter of law. (c) A...

  12. 31 CFR 501.727 - Motion for summary disposition.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...). (b) Decision on motion. The Administrative Law Judge may promptly decide the motion for summary disposition or may defer decision on the motion. The Administrative Law Judge shall issue an order granting a... fact and the party making the motion is entitled to a summary disposition as a matter of law. (c) A...

  13. 31 CFR 501.727 - Motion for summary disposition.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...). (b) Decision on motion. The Administrative Law Judge may promptly decide the motion for summary disposition or may defer decision on the motion. The Administrative Law Judge shall issue an order granting a... fact and the party making the motion is entitled to a summary disposition as a matter of law. (c) A...

  14. 31 CFR 501.727 - Motion for summary disposition.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...). (b) Decision on motion. The Administrative Law Judge may promptly decide the motion for summary disposition or may defer decision on the motion. The Administrative Law Judge shall issue an order granting a... fact and the party making the motion is entitled to a summary disposition as a matter of law. (c) A...

  15. Real Estate Tax Exemption for Continuing Education Programs.

    ERIC Educational Resources Information Center

    Charters, Alexander N.

    A court case in which the issue was whether Syracuse University was entitled to tax exemption for certain real property used for administrative offices, classrooms, student housing, and parking lots by its continuing education programs, particularly the Continuing Education Center for the Public Service, is presented. The finding of the Court is…

  16. 12 CFR 552.4 - Charter amendments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... at the time of adoption, if adopted without change and filed with OTS within 30 days after adoption... be issued from time to time as authorized by the board of directors without further approval of... Section 5 (or in any supplementary sections hereto) shall entitle the holders of any class of a series of...

  17. 12 CFR 552.4 - Charter amendments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... at the time of adoption, if adopted without change and filed with OTS within 30 days after adoption... be issued from time to time as authorized by the board of directors without further approval of... Section 5 (or in any supplementary sections hereto) shall entitle the holders of any class of a series of...

  18. 12 CFR 552.4 - Charter amendments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... at the time of adoption, if adopted without change and filed with OTS within 30 days after adoption... be issued from time to time as authorized by the board of directors without further approval of... Section 5 (or in any supplementary sections hereto) shall entitle the holders of any class of a series of...

  19. 78 FR 15746 - Compendium of Analyses To Investigate Select Level 1 Probabilistic Risk Assessment End-State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0047] Compendium of Analyses To Investigate Select Level 1...) has issued for public comment a document entitled: Compendium of Analyses to Investigate Select Level... begin the search, select ``ADAMS Public Documents'' and then select ``Begin Web- based ADAMS Search...

  20. 27 CFR 478.49 - Duration of license.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Duration of license. 478....49 Duration of license. The license entitles the person to whom issued to engage in the business or activity specified on the license, within the limitations of the Act and the regulations contained in this...

  1. After the Cold War: A New Calculus for Science and Security

    ERIC Educational Resources Information Center

    Wallerstein, Mitchel

    2003-01-01

    Just more than twenty years ago, the author had the privilege of directing a National Academy of Sciences panel that issued a report entitled "Scientific Communication and National Security," known informally as the Corson Report, after Dale Corson, the panel's chair and president emeritus of Cornell University. Thus, for him, today's discussions…

  2. 77 FR 58591 - Report on Waste Burial Charges: Changes in Decommissioning Waste Disposal Costs at Low-Level...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0362] Report on Waste Burial Charges: Changes in Decommissioning Waste Disposal Costs at Low-Level Waste Burial Facilities AGENCY: Nuclear Regulatory Commission... Commission) has issued for public comment a document entitled: NUREG-1307 Revision 15, ``Report on Waste...

  3. Steroid promiscuity: Diversity of enzyme action. Preface.

    PubMed

    Lathe, Richard; Kotelevtsev, Yuri; Mason, J Ian

    2015-07-01

    This Special Issue on the topic of Steroid and Sterol Signaling: Promiscuity and Diversity, dwells on the growing realization that the 'one ligand, one binding site' and 'one enzyme, one reaction' concepts are out of date. Focusing on cytochromes P450 (CYP), hydroxysteroid dehydrogenases (HSDs), and related enzymes, the Special Issue highlights that a single enzyme can bind to diverse substrates, and in different conformations, and can catalyze multiple different conversions (and in different directions), thereby, generating an unexpectedly wide spectrum of ligands that can have subtly different biological actions. This article is part of a Special Issue entitled 'Steroid/Sterol Signaling' . Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. The role of the NG2 proteoglycan in OPC and CNS network function.

    PubMed

    Sakry, Dominik; Trotter, Jacqueline

    2016-05-01

    In the normal mammalian CNS, the NG2 proteoglycan is expressed by oligodendrocyte precursor cells (OPC) but not by any other neural cell-type. NG2 is a type-1 membrane protein, exerting multiple roles in the CNS including intracellular signaling within the OPC, with effects on migration, cytoskeleton interaction and target gene regulation. It has been recently shown that the extracellular region of NG2, in addition to an adhesive function, acts as a soluble ECM component with the capacity to alter defined neuronal network properties. This region of NG2 is thus endowed with neuromodulatory properties. In order to generate biologically active fragments yielding these properties, the sequential cleavage of the NG2 protein by α- and γ-secretases occurs. The basal level of constitutive cleavage is stimulated by neuronal network activity. This processing leads to 4 major NG2 fragments which all have been associated with distinct biological functions. Here we summarize these functions, focusing on recent discoveries and their implications for the CNS. This article is part of a Special Issue entitled SI:NG2-glia(Invited only). Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Active cell mechanics: Measurement and theory.

    PubMed

    Ahmed, Wylie W; Fodor, Étienne; Betz, Timo

    2015-11-01

    Living cells are active mechanical systems that are able to generate forces. Their structure and shape are primarily determined by biopolymer filaments and molecular motors that form the cytoskeleton. Active force generation requires constant consumption of energy to maintain the nonequilibrium activity to drive organization and transport processes necessary for their function. To understand this activity it is necessary to develop new approaches to probe the underlying physical processes. Active cell mechanics incorporates active molecular-scale force generation into the traditional framework of mechanics of materials. This review highlights recent experimental and theoretical developments towards understanding active cell mechanics. We focus primarily on intracellular mechanical measurements and theoretical advances utilizing the Langevin framework. These developing approaches allow a quantitative understanding of nonequilibrium mechanical activity in living cells. This article is part of a Special Issue entitled: Mechanobiology. Copyright © 2015. Published by Elsevier B.V.

  6. Proteome-based bacterial identification using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS): A revolutionary shift in clinical diagnostic microbiology.

    PubMed

    Nomura, Fumio

    2015-06-01

    Rapid and accurate identification of microorganisms, a prerequisite for appropriate patient care and infection control, is a critical function of any clinical microbiology laboratory. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is a quick and reliable method for identification of microorganisms, including bacteria, yeast, molds, and mycobacteria. Indeed, there has been a revolutionary shift in clinical diagnostic microbiology. In the present review, the state of the art and advantages of MALDI-TOF MS-based bacterial identification are described. The potential of this innovative technology for use in strain typing and detection of antibiotic resistance is also discussed. This article is part of a Special Issue entitled: Medical Proteomics. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Heart regeneration.

    PubMed

    Breckwoldt, Kaja; Weinberger, Florian; Eschenhagen, Thomas

    2016-07-01

    Regenerating an injured heart holds great promise for millions of patients suffering from heart diseases. Since the human heart has very limited regenerative capacity, this is a challenging task. Numerous strategies aiming to improve heart function have been developed. In this review we focus on approaches intending to replace damaged heart muscle by new cardiomyocytes. Different strategies for the production of cardiomyocytes from human embryonic stem cells or human induced pluripotent stem cells, by direct reprogramming and induction of cardiomyocyte proliferation are discussed regarding their therapeutic potential and respective advantages and disadvantages. Furthermore, different methods for the transplantation of pluripotent stem cell-derived cardiomyocytes are described and their clinical perspectives are discussed. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. ARF tumor suppression in the nucleolus.

    PubMed

    Maggi, Leonard B; Winkeler, Crystal L; Miceli, Alexander P; Apicelli, Anthony J; Brady, Suzanne N; Kuchenreuther, Michael J; Weber, Jason D

    2014-06-01

    Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Levels of conflict in reasoning modulate right lateral prefrontal cortex.

    PubMed

    Stollstorff, Melanie; Vartanian, Oshin; Goel, Vinod

    2012-01-05

    Right lateral prefrontal cortex (rlPFC) has previously been implicated in logical reasoning under conditions of conflict. A functional magnetic resonance imaging (fMRI) study was conducted to explore its role in conflict more precisely. Specifically, we distinguished between belief-logic conflict and belief-content conflict, and examined the role of rlPFC under each condition. The results demonstrated that a specific region of rlPFC is consistently activated under both types of conflict. Moreover, the results of a parametric analysis demonstrated that the same region was modulated by the level of conflict contained in reasoning arguments. This supports the idea that this specific region is engaged to resolve conflict, including during deductive reasoning. This article is part of a Special Issue entitled "The Cognitive Neuroscience of Thought". Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation.

    PubMed

    Lam, Maggie P Y; Lau, Edward; Scruggs, Sarah B; Wang, Ding; Kim, Tae-Young; Liem, David A; Zhang, Jun; Ryan, Christopher M; Faull, Kym F; Ping, Peipei

    2013-04-09

    We report the development of a multiple-reaction monitoring (MRM) strategy specifically tailored to the detection and quantification of mitochondrial protein phosphorylation. We recently derived 68 MRM transitions specific to protein modifications in the respiratory chain, voltage-dependent anion channel, and adenine nucleotide translocase. Here, we have now expanded the total number of MRM transitions to 176 to cover proteins from the tricarboxylic acid cycle, pyruvate dehydrogenase complex, and branched-chain alpha-keto acid dehydrogenase complex. We utilized the transition set to analyze endogenous protein phosphorylation in human heart, mouse heart, and mouse liver. The data demonstrate the potential utility of the MRM workflow for studying the functional details of mitochondrial phosphorylation signaling. This article is part of a Special Issue entitled: From protein structures to clinical applications. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. 78 FR 35622 - Northwest Pipeline GP; Notice of Intent To Prepare an Environmental Assessment for the Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ... Station and Request for Comments on Environmental Issues The staff of the Federal Energy Regulatory... adjacent to the proposed meter station with a fact sheet prepared by the FERC entitled ``An Interstate... construct and operate a new LNG meter station and associated piping within the yard of its existing Plymouth...

  12. Creative, Professional, and Moral Wherewithal in the Schooling of Immigrant Students

    ERIC Educational Resources Information Center

    Sanchez, Patricia

    2012-01-01

    The author is grateful that this journal has taken on the production of a special theme issue entitled "Immigration and Teacher Education: The Crisis and the Opportunity." In her estimation, the "crisis" is not so much that the United States may indeed continue to enroll more immigrant children and youth in its schooling system…

  13. Media and Violence. Part One: Making the Connections. Media & Values 62.

    ERIC Educational Resources Information Center

    Silver, Rosalind, Ed.

    1993-01-01

    This issue of "Media & Values" explores the influence of mass media and violence in our society. The essays present various interpretations of that influence and the implications for the society. A special section entitled "Media and Violence Forum" contains 10 articles. Articles include: (1) "No Doubt About It - TV Violence Affects Behavior"…

  14. International trends in health science librarianship part 20: Russia.

    PubMed

    Murphy, Jeannette; Jargin, Serge

    2017-03-01

    This is the last in a series of articles exploring international trends in health science librarianship in the 21st century. The focus of the present issue is Russia. The next feature column will initiate a new series entitled New Directions in Health Science Librarianship. The first contribution will be from Australia. JM. © 2017 Health Libraries Group.

  15. 77 FR 23116 - Privacy Act of 1974; Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... DEPARTMENT OF JUSTICE 28 CFR Part 16 [CPCLO Order No. 009-2012] Privacy Act of 1974... Department) is issuing a final rule for a new Department-wide Privacy Act system of records entitled, Debt...), (3), and (4); (e)(1), (2), (3), (4)(G), (H) and (I), (5) and (8); (f) and (g) of the Privacy Act for...

  16. 77 FR 71404 - Notice of Intent to License Government-Owned Inventions; Intent to License on a Partially...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent to License Government-Owned Inventions; Intent to License on a Partially-Exclusive Basis AGENCY: Department of the Army, DoD. ACTION..., issued 07/ 28/2009 and entitled ``Radiation source with self-aligning optics,'' U.S. Patent 7,852,469...

  17. Correction to “Apollo 11 Mission Commemorated”

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2009-08-01

    In the 28 July 2009 issue of Eos (90(30), 258), a date was incorrect in the news item entitled “Apollo 11 Mission Commemorated.” NASA astronaut Eugene Cernan was referring to the 1970s, not the 1960s, in talking about his expectation of when humans would be back on the Moon. Eos regrets this error.

  18. Post-War Trauma and Reconciliation in Bosnia-Herzegovina: Observations, Experiences, and Implications for Marriage and Family Therapy.

    ERIC Educational Resources Information Center

    Nelson, Briana S.

    2003-01-01

    The 1992-1995 war in Bosnia-Herzegovina caused mush devastation in that region of the world. This article describes the themes and issues that emerged from information gained from interviews with Bosnian professionals through a project entitled "Trauma and Reconciliation in Bosnia-Herzegovina." Recommendations and implications for family…

  19. "Forest Grove School District v. T.A.": The Supreme Court and Unilateral Private Placements

    ERIC Educational Resources Information Center

    Yell, Mitchell L.; Katsiyannis, Antonis; Collins, Terri S.

    2010-01-01

    On June 22, 2009, the U.S. Supreme Court issued its decision in the case "Forest Grove School District v. T.A." (hereafter "Forest Grove"). In "Forest Grove," the High Court answered the question of whether the parents of students with disabilities are entitled to reimbursement for the costs associated with placing…

  20. 12 CFR 261b.1 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Basis and scope. 261b.1 Section 261b.1 Banks... REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.1 Basis and scope. This part is issued by the Board of... public is entitled to the fullest practicable information regarding the decision making processes of the...

  1. Reforms in Pedagogy and the Confucian Tradition: Looking below the Surface

    ERIC Educational Resources Information Center

    Ho, Felix M.

    2018-01-01

    This Forum article addresses some of the issues raised in the article by Ying-Syuan Huang and Anila Asghar's paper entitled: "Science education reform in Confucian learning cultures: teachers' perspectives on policy and practice in Taiwan." An attempt is made to highlight the need for a more nuanced approach in considering the Confucian…

  2. 32 CFR 534.3 - Allowable expenses for witnesses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the trial in obedience to such subpoena, is entitled to mileage between his residence and the place of... civilian by a military court or board which has not express statutory authority to issue such process, such... Regulations. (See 6 Comp. Gen. 712.) (ii) There is no authority for payment by the Government of fees to an...

  3. 32 CFR 534.3 - Allowable expenses for witnesses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the trial in obedience to such subpoena, is entitled to mileage between his residence and the place of... civilian by a military court or board which has not express statutory authority to issue such process, such... Regulations. (See 6 Comp. Gen. 712.) (ii) There is no authority for payment by the Government of fees to an...

  4. 32 CFR 534.3 - Allowable expenses for witnesses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the trial in obedience to such subpoena, is entitled to mileage between his residence and the place of... civilian by a military court or board which has not express statutory authority to issue such process, such... Regulations. (See 6 Comp. Gen. 712.) (ii) There is no authority for payment by the Government of fees to an...

  5. 32 CFR 534.3 - Allowable expenses for witnesses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the trial in obedience to such subpoena, is entitled to mileage between his residence and the place of... civilian by a military court or board which has not express statutory authority to issue such process, such... Regulations. (See 6 Comp. Gen. 712.) (ii) There is no authority for payment by the Government of fees to an...

  6. Special Needs. Viewpoints. A Series of Occasional Papers on Basic Education. Issue No. 2.

    ERIC Educational Resources Information Center

    Adult Literacy and Basic Skills Unit, London (England).

    This collection of papers focuses on working with adults who have special needs. In her paper entitled "Literacy and the Visually Handicapped," Janice E. Mason examines ways in which strategies for meeting the needs of visually handicapped persons can be integrated into literacy programs. "Singer and Listener: Basic Education Work…

  7. Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests.

    USDA-ARS?s Scientific Manuscript database

    The current review is part of a special issue entitled “Role of dietary pattern, foods, nutrients and nutraceuticals in supporting cancer prevention and treatment”; it deals with the description of a pharmacological strategy aiming to actually determine the potential contribution of food-related com...

  8. Triple Science GCSEs: Collaborative Approaches. GCSEs in Biology, Chemistry and Physics

    ERIC Educational Resources Information Center

    Beamish, Val; Rhys, Jenny, Ed.

    2007-01-01

    Many schools that are preparing to introduce Triple Science GCSEs may find it helpful to collaborate with other schools or other institutions to share expertise and explore how best to deliver the entitlement. This publication looks at some of the issues facing schools in doing this. It focuses on the benefits of collaborative working and the…

  9. Summary of prospective global change impacts on northern U.S. forest ecosystems

    Treesearch

    Richard A. Birdsey; Robert A. Mickler; John Hom; Linda S. Heath

    2000-01-01

    In January 1989, the President's Fiscal Year 1990 Budget to the Congress was accompanied by a report entitled, "Our Changing Planet: A U.S. Strategy for Global Change Research" (Committee on Earth Sciences, 1989). The report focused the attention of policy makers on the significant environmental issues arising from natural and human-induced changes in...

  10. Military Famine, Human Rights, and Child Hunger: A Cross-National Analysis, 1990-2000

    ERIC Educational Resources Information Center

    Jenkins, J. Craig; Scanlan, Stephen J.; Peterson, Lindsey

    2007-01-01

    Discussions of world hunger have focused on economic growth and international food aid, assuming that food supply is the critical issue. The authors show that food access rooted in social stratification and military power is the central problem. Synthesizing the entitlement and military famine approaches to hunger, the authors examine the effects…

  11. Argumentation and Indigenous Knowledge: Socio-Historical Influences in Contextualizing an Argumentation Model in South African Schools

    ERIC Educational Resources Information Center

    Gallard Martinez, Alejandro J.

    2011-01-01

    This forum considers argumentation as a means of science teaching in South African schools, through the integration of indigenous knowledge (IK). It addresses issues raised in Mariana G. Hewson and Meshach B. Ogunniyi's paper entitled: Argumentation-teaching as a method to introduce indigenous knowledge into science classrooms: opportunities and…

  12. What are the implications of the Institute of Medicine report "The future of nursing: leading change, advancing health" for school nursing practice?

    PubMed

    Sheetz, Anne H

    2012-11-01

    In 2010, the Robert Wood Johnson Foundation Initiative at the Institute of Medicine issued a comprehensive report entitled, "The future of nursing: leading change, advancing health." The following is a synopsis of the report, including excerpts, recommendations, and a discussion of school nursing implications.

  13. Is Elevating Sir John A. Macdonald Really Worth It? Hitting the Reset Button on Canada's Founding Narrative in the Classroom

    ERIC Educational Resources Information Center

    Gaudry, Adam

    2017-01-01

    This special issue of "Canadian Social Studies," entitled "Monumental Mistakes? Confronting Difficult Pasts," has brought together a diverse range of scholars offering insights into discussions regarding removing or altering monuments, buildings, and other reminders of difficult histories. The editors have requested that…

  14. Academic Freedom and Student Grading in Greek Higher Education

    ERIC Educational Resources Information Center

    Papadimitriou, Antigoni

    2011-01-01

    The issue of who has the final say on academic standards (grading), academics or managers, has hitherto not arisen in Greece. Professors entitled to research, to teach and to inquire is a freedom expressed by the Greek Constitution. This article presents a contemporary view and raises concerns about the future and the longevity of academic freedom…

  15. Access to Knowledge: The Continuing Agenda for Our Nation's Schools. Revised Edition.

    ERIC Educational Resources Information Center

    Goodlad, John I., Ed.; Keating, Pamela, Ed.

    This book presents a collection of essays by education researchers and practitioners about issues of educational equity and excellence. The authors examine the problem of failure in schools and describe the various curricular and structural factors that block access to an equal and quality education for all students. Chapters are entitled: (1)…

  16. Twilight Musings Concerning the Gamma Doradus Phenomenon

    NASA Astrophysics Data System (ADS)

    Kaye, A. B.; Zerbi, F. M.

    1997-07-01

    In this contribution, we intend to address some of the points in the article entitled ``Night Thoughts on Slowly Variable F-Type Stars'' by Gautschy and Loeffler in the Delta Scuti Newsletter, issue 10 (1996). We present these points as direct results of the conference ``A Half-Century of Stellar Pulsation'' at Los Alamos National Laboratory in June 1997.

  17. 12 CFR 152.4 - Charter amendments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... this part, shall be approved at the time of adoption, if adopted without change and filed with the OCC... of each such class]. The shares may be issued from time to time as authorized by the board of...) shall entitle the holders of any class of a series of capital stock to vote as a separate class or...

  18. Food and Population: A Global Concern [and] The Paradoxes of World Hunger.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    1984-01-01

    Student and teacher materials are provided for a secondary unit on world hunger. The student materials are contained in a module entitled "Food and Population: A Global Concern," distributed with the newsletter "Interchange." The teacher materials are contained in the issue of the newsletter itself, subtitled "The Paradoxes of World Hunger." A…

  19. Response to Pienemann's Critique of Zhang and Lantolf (2015)

    ERIC Educational Resources Information Center

    Lantolf, James P.; Zhang, Xian

    2015-01-01

    We respond here to Pienemann's critique of our study that appeared earlier this year in the Language Learning Special Issue entitled "Orders and Sequences in the Acquisition of L2 Morphosyntax, 40 Years On" and guest edited by Jan Hulstijn, Rod Ellis, and Søren Eskildsen. Pienemann objected to our claim that the Teachability Hypothesis…

  20. Media and Violence. Part Two: Searching for Solutions. Media & Values 63.

    ERIC Educational Resources Information Center

    Silver, Rosalind, Ed.

    1993-01-01

    This issue of "Media & Values" explores the influence of mass media and violence in society. The essays present various interpretations of that influence and the implications for the society. A special section entitled "Forum: Searching for Solutions" contains 5 articles. Articles include: (1) "20 Ways to Create a Culture of Caring" (Jay Dover);…

  1. Tour of a labyrinth: exploring the vertebrate nose.

    PubMed

    Van Valkenburgh, Blaire; Smith, Timothy D; Craven, Brent A

    2014-11-01

    This special issue of The Anatomical Record is the outcome of a symposium entitled "Inside the Vertebrate Nose: Evolution, Structure and Function." The skeletal framework of the nasal cavity is a complicated structure that often houses sinuses and comprises an internal skeleton of bone or cartilage that can vary greatly in architecture among species. The nose serves multiple functions, including olfaction and respiratory air-conditioning, and its morphology is constrained by evolution, development, and conflicting demands on cranial space, such as enlarged orbits. The nasal cavity of vertebrates has received much more attention in the last decade due to the emergence of nondestructive methods that allow improved visualization of the internal anatomy of the skull, such as high-resolution x-ray computed tomography and magnetic resonance imaging. The 17 articles included here represent a broad range of investigators, from paleontologists to engineers, who approach the nose from different perspectives. Key topics include the evolution and development of the nose, its comparative anatomy and function, and airflow through the nasal cavity of individual species. In addition, this special issue includes review articles on anatomical reduction of the olfactory apparatus in both cetaceans and primates (the vomeronasal system), as well as the molecular biology of olfaction in vertebrates. Together these articles provide an expansive summary of our current understanding of vertebrate nasal anatomy and function. In this introduction, we provide background information and an overview of each of the three primary topics, and place each article within the context of previous research and the major challenges that lie ahead. © 2014 Wiley Periodicals, Inc.

  2. 48 CFR 25.302-4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... performing private security functions in designated areas are addressed at 32 CFR part 159, entitled “Private... for weapons; registering and identifying armored vehicles, helicopters, and other military vehicles; and reporting specified incidents in which personnel performing private security functions under a...

  3. Physiological enzymology: The next frontier in understanding protein structure and function at the cellular level.

    PubMed

    Lee, Irene; Berdis, Anthony J

    2016-01-01

    Historically, the study of proteins has relied heavily on characterizing the activity of a single purified protein isolated from other cellular components. This classic approach allowed scientists to unambiguously define the intrinsic kinetic and chemical properties of that protein. The ultimate hope was to extrapolate this information toward understanding how the enzyme or receptor behaves within its native cellular context. These types of detailed in vitro analyses were necessary to reduce the innate complexities of measuring the singular activity and biochemical properties of a specific enzyme without interference from other enzymes and potential competing substrates. However, recent developments in fields encompassing cell biology, molecular imaging, and chemical biology now provide the unique chemical tools and instrumentation to study protein structure, function, and regulation in their native cellular environment. These advancements provide the foundation for a new field, coined physiological enzymology, which quantifies the function and regulation of enzymes and proteins at the cellular level. In this Special Edition, we explore the area of Physiological Enzymology and Protein Function through a series of review articles that focus on the tools and techniques used to measure the cellular activity of proteins inside living cells. This article is part of a Special Issue entitled: Physiological Enzymology and Protein Functions. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Recent advances in the Suf Fe-S cluster biogenesis pathway: Beyond the Proteobacteria.

    PubMed

    Outten, F Wayne

    2015-06-01

    Fe-S clusters play critical roles in cellular function throughout all three kingdoms of life. Consequently, Fe-S cluster biogenesis systems are present in most organisms. The Suf (sulfur formation) system is the most ancient of the three characterized Fe-S cluster biogenesis pathways, which also include the Isc and Nif systems. Much of the first work on the Suf system took place in Gram-negative Proteobacteria used as model organisms. These early studies led to a wealth of biochemical, genetic, and physiological information on Suf function. From those studies we have learned that SufB functions as an Fe-S scaffold in conjunction with SufC (and in some cases SufD). SufS and SufE together mobilize sulfur for cluster assembly and SufA traffics the complete Fe-S cluster from SufB to target apo-proteins. However, recent progress on the Suf system in other organisms has opened up new avenues of research and new hypotheses about Suf function. This review focuses primarily on the most recent discoveries about the Suf pathway and where those new models may lead the field. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. 77 FR 43039 - Federal Acquisition Regulation; Contractors Performing Private Security Functions Outside the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Federal Acquisition Regulation; Contractors Performing Private Security Functions Outside the United.... 110-181, enacted January 28, 2008), section 862, entitled ``Contractors Performing Private Security... NDAA required standardization of rules for private security contractors that are performing in...

  6. Seven Experiment Designs Addressing Problems of Safety and Capacity on Two-Lane Rural Highways : Volume 7. Experimental Design to Develop and Evaluate Measures for Reducing the Effects of Roadside Friction on Traffic Flow

    DOT National Transportation Integrated Search

    1994-04-01

    This operational test case study is one of six performed in response to a Volpe National Transportation Systems Center technical task directive (TTD) to Science Applications International Corporation (SAIC) entitled, "IVHS Institutional Issues and Ca...

  7. Seven Experiment Designs Addressing Problems of Safety and Capacity on Two-Lane Rural Highways : Volume 4. Experimental Design to Develop and Evaluate Remedial Aids to Urban Drivers of Slow Moving Vehicles on a Grade

    DOT National Transportation Integrated Search

    1994-04-01

    This operational test case study is one of six performed in response to a Volpe National Transportation Systems Center technical task directive (TTD) to Science Applications International Corporation (SAIC) entitled, IVHS Institutional Issues and ...

  8. Feminist Perspectives on TANF Reauthorization: An Introduction to Key Issues for the Future of Welfare Reform. Briefing Paper.

    ERIC Educational Resources Information Center

    Peterson, Janice

    Current debates about welfare reform center on the upcoming reauthorization of the Temporary Assistance for Needy Families (TANF) legislation. The provisions of TANF include the elimination of the entitlement to cash assistance, block grant funding to the states, mandatory work requirements, sanctions, a 5-year limit on cash assistance, and…

  9. 77 FR 60142 - Notice of Lodging of Proposed Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... District Court for the District of Arizona in the lawsuit entitled United States v. CEMEX Construction... resolves the civil claims alleged in the complaint and in the Finding and Notice of Violation issued to the... Division, and should refer to United States v. CEMEX Construction Materials South, LLC, D.J. Ref. No. 90-5...

  10. 21 CFR 1305.04 - Persons entitled to order Schedule I and II controlled substances.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to order Schedule I and II controlled substances. (a) Only persons who are registered with DEA under... are registered with DEA under section 1008 of the Act (21 U.S.C. 958) to export these substances may obtain and use DEA Form 222 (order forms) or issue electronic orders for these substances. Persons not...

  11. 21 CFR 1305.04 - Persons entitled to order Schedule I and II controlled substances.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to order Schedule I and II controlled substances. (a) Only persons who are registered with DEA under... are registered with DEA under section 1008 of the Act (21 U.S.C. 958) to export these substances may obtain and use DEA Form 222 (order forms) or issue electronic orders for these substances. Persons not...

  12. Transition from 'model-based' to 'model-free' behavioral control in addiction: Involvement of the orbitofrontal cortex and dorsolateral striatum.

    PubMed

    Lucantonio, Federica; Caprioli, Daniele; Schoenbaum, Geoffrey

    2014-01-01

    Cocaine addiction is a complex and multidimensional process involving a number of behavioral and neural forms of plasticity. The behavioral transition from voluntary drug use to compulsive drug taking may be explained at the neural level by drug-induced changes in function or interaction between a flexible planning system, associated with prefrontal cortical regions, and a rigid habit system, associated with the striatum. The dichotomy between these two systems is operationalized in computational theory by positing model-based and model-free learning mechanisms, the former relying on an "internal model" of the environment and the latter on pre-computed or cached values to control behavior. In this review, we will suggest that model-free and model-based learning mechanisms appear to be differentially affected, at least in the case of psychostimulants such as cocaine, with the former being enhanced while the latter are disrupted. As a result, the behavior of long-term drug users becomes less flexible and responsive to the desirability of expected outcomes and more habitual, based on the long history of reinforcement. To support our specific proposal, we will review recent neural and behavioral evidence on the effect of psychostimulant exposure on orbitofrontal and dorsolateral striatum structure and function. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'. Published by Elsevier Ltd.

  13. Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex.

    PubMed

    Xing, Bo; Li, Yan-Chun; Gao, Wen-Jun

    2016-06-15

    Among the neuromodulators that regulate prefrontal cortical circuit function, the catecholamine transmitters norepinephrine (NE) and dopamine (DA) stand out as powerful players in working memory and attention. Perturbation of either NE or DA signaling is implicated in the pathogenesis of several neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), schizophrenia, and drug addiction. Although the precise mechanisms employed by NE and DA to cooperatively control prefrontal functions are not fully understood, emerging research indicates that both transmitters regulate electrical and biochemical aspects of neuronal function by modulating convergent ionic and synaptic signaling in the prefrontal cortex (PFC). This review summarizes previous studies that investigated the effects of both NE and DA on excitatory and inhibitory transmissions in the prefrontal cortical circuitry. Specifically, we focus on the functional interaction between NE and DA in prefrontal cortical local circuitry, synaptic integration, signaling pathways, and receptor properties. Although it is clear that both NE and DA innervate the PFC extensively and modulate synaptic function by activating distinctly different receptor subtypes and signaling pathways, it remains unclear how these two systems coordinate their actions to optimize PFC function for appropriate behavior. Throughout this review, we provide perspectives and highlight several critical topics for future studies. This article is part of a Special Issue entitled SI: Noradrenergic System. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Multi-Scale Sizing of Lightweight Multifunctional Spacecraft Structural Components

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.

    2005-01-01

    This document is the final report for the project entitled, "Multi-Scale Sizing of Lightweight Multifunctional Spacecraft Structural Components," funded under the NRA entitled "Cross-Enterprise Technology Development Program" issued by the NASA Office of Space Science in 2000. The project was funded in 2001, and spanned a four year period from March, 2001 to February, 2005. Through enhancements to and synthesis of unique, state of the art structural mechanics and micromechanics analysis software, a new multi-scale tool has been developed that enables design, analysis, and sizing of advance lightweight composite and smart materials and structures from the full vehicle, to the stiffened structure, to the micro (fiber and matrix) scales. The new software tool has broad, cross-cutting value to current and future NASA missions that will rely on advanced composite and smart materials and structures.

  15. Unheard Voices: The Need for HIV Research and Prevention Priorities for YMSM in the Global Context.

    PubMed

    Hall, Casey D; Murdock, Daniel; Nehl, Eric J; Wong, Frank Y

    2016-06-01

    This commentary considers the AIDS Education and Prevention special issue (volume 28, number 3) entitled "Behavioral HIV Prevention Interventions for Diverse Young Men Who Have Sex with Men (MSM)." The research presented in this special issue highlights the importance of addressing sub-populations of young MSM in order to better understand the unique realities and risk-factors affecting HIV epidemics and intervention needs. Here, we focus on several broad topics raised in this special issue and comment on their implications for HIV research and practice targeting young MSM in low- and middle-income countries. We consider issues relevant to reaching hidden populations, tailoring interventions, and integrating new communications and bio-medical technologies in research and practice in low-resource settings.

  16. Visual Basic programs for spreadsheet analysis.

    PubMed

    Hunt, Bruce

    2005-01-01

    A collection of Visual Basic programs, entitled Function.xls, has been written for ground water spreadsheet calculations. This collection includes programs for calculating mathematical functions and for evaluating analytical solutions in ground water hydraulics and contaminant transport. Several spreadsheet examples are given to illustrate their use.

  17. Comparison of mechanistic transport cycle models of ABC exporters.

    PubMed

    Szöllősi, Dániel; Rose-Sperling, Dania; Hellmich, Ute A; Stockner, Thomas

    2018-04-01

    ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out essential substrate transport reactions across cell membranes. Their transmembrane domains bind and translocate substrates and are connected to a pair of nucleotide binding domains, which bind and hydrolyze ATP to energize import or export of substrates. Over four decades of investigations into ABC transporters have revealed numerous details from atomic-level structural insights to their functional and physiological roles. Despite all these advances, a comprehensive understanding of the mechanistic principles of ABC transporter function remains elusive. The human multidrug resistance transporter ABCB1, also referred to as P-glycoprotein (P-gp), is one of the most intensively studied ABC exporters. Using ABCB1 as the reference point, we aim to compare the dominating mechanistic models of substrate transport and ATP hydrolysis for ABC exporters and to highlight the experimental and computational evidence in their support. In particular, we point out in silico studies that enhance and complement available biochemical data. "This article is part of a Special Issue entitled: Beyond the Structure-Function Horizon of Membrane Proteins edited by Ute Hellmich, Rupak Doshi and Benjamin McIlwain." Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  18. Addictions Neuroclinical Assessment: A reverse translational approach.

    PubMed

    Kwako, Laura E; Momenan, Reza; Grodin, Erica N; Litten, Raye Z; Koob, George F; Goldman, David

    2017-08-01

    Incentive salience, negative emotionality, and executive function are functional domains that are etiologic in the initiation and progression of addictive disorders, having been implicated in humans with addictive disorders and in animal models of addictions. Measures of these three neuroscience-based functional domains can capture much of the effects of inheritance and early exposures that lead to trait vulnerability shared across different addictive disorders. For specific addictive disorders, these measures can be supplemented by agent specific measures such as those that access pharmacodynamic and pharmacokinetic variation attributable to agent-specific gatekeeper molecules including receptors and drug-metabolizing enzymes. Herein, we focus on the translation and reverse translation of knowledge derived from animal models of addiction to the human condition via measures of neurobiological processes that are orthologous in animals and humans, and that are shared in addictions to different agents. Based on preclinical data and human studies, measures of these domains in a general framework of an Addictions Neuroclinical Assessment (ANA) can transform the assessment and nosology of addictive disorders, and can be informative for staging disease progression. We consider next steps and challenges for implementation of ANA in clinical care and research. This article is part of the Special Issue entitled "Alcoholism". Published by Elsevier Ltd.

  19. Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease.

    PubMed

    Simon, Matthew J; Iliff, Jeffrey J

    2016-03-01

    Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of solutes from the brain interstitium, serving an important homeostatic role for the function of the central nervous system. Disruption of normal CSF circulation and turnover is believed to contribute to the development of many diseases, including neurodegenerative conditions such as Alzheimer's disease, ischemic and traumatic brain injury, and neuroinflammatory conditions such as multiple sclerosis. Recent insights into CSF biology suggesting that CSF and interstitial fluid exchange along a brain-wide network of perivascular spaces termed the 'glymphatic' system suggest that CSF circulation may interact intimately with glial and vascular function to regulate basic aspects of brain function. Dysfunction within this glial vascular network, which is a feature of the aging and injured brain, is a potentially critical link between brain injury, neuroinflammation and the development of chronic neurodegeneration. Ongoing research within this field may provide a powerful new framework for understanding the common links between neurodegenerative, neurovascular and neuroinflammatory disease, in addition to providing potentially novel therapeutic targets for these conditions. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Molecular modeling of biomolecules by paramagnetic NMR and computational hybrid methods.

    PubMed

    Pilla, Kala Bharath; Gaalswyk, Kari; MacCallum, Justin L

    2017-11-01

    The 3D atomic structures of biomolecules and their complexes are key to our understanding of biomolecular function, recognition, and mechanism. However, it is often difficult to obtain structures, particularly for systems that are complex, dynamic, disordered, or exist in environments like cell membranes. In such cases sparse data from a variety of paramagnetic NMR experiments offers one possible source of structural information. These restraints can be incorporated in computer modeling algorithms that can accurately translate the sparse experimental data into full 3D atomic structures. In this review, we discuss various types of paramagnetic NMR/computational hybrid modeling techniques that can be applied to successful modeling of not only the atomic structure of proteins but also their interacting partners. This article is part of a Special Issue entitled: Biophysics in Canada, edited by Lewis Kay, John Baenziger, Albert Berghuis and Peter Tieleman. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Biophysics of α-synuclein membrane interactions.

    PubMed

    Pfefferkorn, Candace M; Jiang, Zhiping; Lee, Jennifer C

    2012-02-01

    Membrane proteins participate in nearly all cellular processes; however, because of experimental limitations, their characterization lags far behind that of soluble proteins. Peripheral membrane proteins are particularly challenging to study because of their inherent propensity to adopt multiple and/or transient conformations in solution and upon membrane association. In this review, we summarize useful biophysical techniques for the study of peripheral membrane proteins and their application in the characterization of the membrane interactions of the natively unfolded and Parkinson's disease (PD) related protein, α-synuclein (α-syn). We give particular focus to studies that have led to the current understanding of membrane-bound α-syn structure and the elucidation of specific membrane properties that affect α-syn-membrane binding. Finally, we discuss biophysical evidence supporting a key role for membranes and α-syn in PD pathogenesis. This article is part of a Special Issue entitled: Membrane protein structure and function. Copyright © 2011. Published by Elsevier B.V.

  2. Cancer metabolism in space and time: Beyond the Warburg effect.

    PubMed

    Danhier, Pierre; Bański, Piotr; Payen, Valéry L; Grasso, Debora; Ippolito, Luigi; Sonveaux, Pierre; Porporato, Paolo E

    2017-08-01

    Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several metabolites exert a signaling function promoting tumor growth and progression. A cancer tissue cannot be simply reduced to a bulk of proliferating cells. Tumors are indeed complex and dynamic structures where single cells can heterogeneously perform various biological activities with different metabolic requirements. Because tumors are composed of different types of cells with metabolic activities affected by different spatial and temporal contexts, it is important to address metabolism taking into account cellular and biological heterogeneity. In this review, we describe this heterogeneity also in metabolic fluxes, thus showing the relative contribution of different metabolic activities to tumor progression according to the cellular context. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. TLX: A master regulator for neural stem cell maintenance and neurogenesis.

    PubMed

    Islam, Mohammed M; Zhang, Chun-Li

    2015-02-01

    The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is specifically localized to the neurogenic regions of the forebrain and retina throughout development and adulthood. TLX regulates the expression of genes involved in multiple pathways, such as the cell cycle, DNA replication, and cell adhesion. These roles are primarily performed through the transcriptional repression or activation of downstream target genes. Emerging evidence suggests that the misregulation of TLX might play a role in the onset and progression of human neurological disorders making this factor an ideal therapeutic target. Here, we review the current understanding of TLX function, expression, regulation, and activity significant to NSC maintenance, adult neurogenesis, and brain plasticity. This article is part of a Special Issue entitled: Nuclear receptors in animal development. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Membrane contact sites, ancient and central hubs of cellular lipid logistics.

    PubMed

    Jain, Amrita; Holthuis, Joost C M

    2017-09-01

    Membrane contact sites (MCSs) are regions where two organelles are closely apposed to facilitate molecular communication and promote a functional integration of compartmentalized cellular processes. There is growing evidence that MCSs play key roles in controlling intracellular lipid flows and distributions. Strikingly, even organelles connected by vesicular trafficking exchange lipids en bulk via lipid transfer proteins that operate at MCSs. Herein, we describe how MCSs developed into central hubs of lipid logistics during the evolution of eukaryotic cells. We then focus on how modern eukaryotes exploit MCSs to help solve a major logistical problem, namely to preserve the unique lipid mixtures of their early and late secretory organelles in the face of extensive vesicular trafficking. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. Copyright © 2017. Published by Elsevier B.V.

  5. Molecular simulation aspects of amyloid peptides at membrane interface.

    PubMed

    Liu, Yonglan; Ren, Baiping; Zhang, Yanxian; Sun, Yan; Chang, Yung; Liang, Guizhao; Xu, Lijian; Zheng, Jie

    2018-02-06

    The interactions of amyloid peptides with cell membranes play an important role in maintaining the integrity and functionality of cell membrane. A thorough molecular-level understanding of the structure, dynamics, and interactions between amyloid peptides and cell membranes is critical to amyloid aggregation and toxicity mechanisms for the bench-to-bedside applications. Here we review the most recent computational studies of amyloid peptides at model cell membranes. Different mechanisms of action of amyloid peptides on/in cell membranes, targeted by different computational techniques at different lengthscales and timescales, are rationally discussed. Finally, we have proposed some new insights into the remaining challenges and perspectives for future studies to improve our understanding of the activity of amyloid peptides associated with protein-misfolding diseases. This article is part of a Special Issue entitled: Protein Aggregation and Misfolding at the Cell Membrane Interface edited by Ayyalusamy Ramamoorthy. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Avanti lipid tools: connecting lipids, technology, and cell biology.

    PubMed

    Sims, Kacee H; Tytler, Ewan M; Tipton, John; Hill, Kasey L; Burgess, Stephen W; Shaw, Walter A

    2014-08-01

    Lipid research is challenging owing to the complexity and diversity of the lipidome. Here we review a set of experimental tools developed for the seasoned lipid researcher, as well as, those who are new to the field of lipid research. Novel tools for probing protein-lipid interactions, applications for lipid binding antibodies, enhanced systems for the cellular delivery of lipids, improved visualization of lipid membranes using gold-labeled lipids, and advances in mass spectrometric analysis techniques will be discussed. Because lipid mediators are known to participate in a host of signal transduction and trafficking pathways within the cell, a comprehensive lipid toolbox that aids the science of lipidomics research is essential to better understand the molecular mechanisms of interactions between cellular components. This article is part of a Special Issue entitled Tools to study lipid functions. Copyright © 2014. Published by Elsevier B.V.

  7. NRRI summary of New York Public Service Commission: Staff investigation of Orange and Rockland Utilities, Inc.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-12-31

    In June 1995, the New York Public Service Commission (NYPSC) released a Staff investigation of Orange and Rockland Utilities, Inc. (O&R). The primary focus of the Staffs investigation was the Corporate Policy and External Affairs Department, a restricted disbursements account, the Internal Auditing Department, and O&R officer malfeasance. The Staffs` investigation uncovered widespread, alleged instances of lax internal controls, unethical and illegal actions, and lavish officer behavior. In addition, the Staff investigated O&R`s internal control and purchasing functions. The Staff proposed a series of recommendations to improve the Company`s internal control, purchasing, ethical, climate and addressed the issue of amore » New York ratepayer reimbursement. The Staffs findings and recommendations were presented in the form of a report, entitled Staff Investigation of Orange and Rockland Utilities, Inc. This article summarizes the Report.« less

  8. Outstanding Research Issues in Systematic Technology Prioritization for New Space Missions: Workshop Proceedings

    NASA Technical Reports Server (NTRS)

    Weisbin, C. R. (Editor)

    2004-01-01

    A workshop entitled, "Outstanding Research Issues in Systematic Technology Prioritization for New Space Missions," was convened on April 21-22, 2004 in San Diego, California to review the status of methods for objective resource allocation, to discuss the research barriers remaining, and to formulate recommendations for future development and application. The workshop explored the state-of-the-art in decision analysis in the context of being able to objectively allocate constrained technical resources to enable future space missions and optimize science return. This article summarizes the highlights of the meeting results.

  9. Knowledge based systems: A critical survey of major concepts, issues and techniques. Visuals

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Kavi, Srinu

    1984-01-01

    This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled, Knowledge Based Systems: A Critical Survey of Major Concepts, Issues, and Techniques, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-9. The objectives of the report are to: examine various techniques used to build the KBS; to examine at least one KBS in detail, i.e., a case study; to list and identify limitations and problems with the KBS; to suggest future areas of research; and to provide extensive reference materials.

  10. Teaching Research Integrity and Bioethics to Science Undergraduates

    PubMed Central

    2005-01-01

    Undergraduate students in the Department of Biomedical Sciences at the University of South Alabama, Mobile, are required to take a course entitled “Issues in Biomedical Sciences,” designed to increase students' awareness about bioethical questions and issues concerning research integrity. This paper describes the main features of this course and summarizes the results of a survey designed to evaluate the students' perceptions about the course. A summary of this study was presented at the 2002 Conference on Research Integrity in Potomac, MD, sponsored by the Office of Research Integrity of the National Institutes of Health. PMID:16341260

  11. NASA Tech Briefs, April 1995. Volume 19, No. 4

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This issue of the NASA Tech Briefs has a special focus section on video and imaging, a feature on the NASA invention of the year, and a resource report on the Dryden Flight Research Center. The issue also contains articles on electronic components and circuits, electronic systems, physical sciences, materials, computer programs, mechanics, machinery, manufacturing/fabrication, mathematics and information sciences and life sciences. In addition to the standard articles in the NASA Tech brief, this contains a supplement entitled "Laser Tech Briefs" which features an article on the National Ignition Facility, and other articles on the use of Lasers.

  12. Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity☆

    PubMed Central

    Marzano, Valeria; Santini, Simonetta; Rossi, Claudia; Zucchelli, Mirco; D'Alessandro, Annamaria; Marchetti, Carlo; Mingardi, Michele; Stagni, Venturina; Barilà, Daniela; Urbani, Andrea

    2012-01-01

    Ataxia Telangiectasia Mutated (ATM) protein kinase is a key effector in the modulation of the functionality of some important stress responses, including DNA damage and oxidative stress response, and its deficiency is the hallmark of Ataxia Telangiectasia (A-T), a rare genetic disorder. ATM modulates the activity of hundreds of target proteins, essential for the correct balance between proliferation and cell death. The aim of this study is to evaluate the phenotypic adaptation at the protein level both in basal condition and in presence of proteasome blockage in order to identify the molecules whose level and stability are modulated through ATM expression. We pursued a comparative analysis of ATM deficient and proficient lymphoblastoid cells by label-free shotgun proteomic experiments comparing the panel of proteins differentially expressed. Through a non-supervised comparative bioinformatic analysis these data provided an insight on the functional role of ATM deficiency in cellular carbohydrate metabolism's regulation. This hypothesis has been demonstrated by targeted metabolic fingerprint analysis SRM (Selected Reaction Monitoring) on specific thermodynamic checkpoints of glycolysis. This article is part of a Special Issue entitled: Translational Proteomics. PMID:22641158

  13. Mammalian lipoxygenases and their biological relevance.

    PubMed

    Kuhn, Hartmut; Banthiya, Swathi; van Leyen, Klaus

    2015-04-01

    Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated not only in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance. As other fatty acid dioxygenases LOXs oxidize polyunsaturated fatty acids to their corresponding hydroperoxy derivatives, which are further transformed to bioactive lipid mediators (eicosanoids and related substances). On the other hand, lipoxygenases are key players in the regulation of the cellular redox homeostasis, which is an important element in gene expression regulation. Although the first mammalian lipoxygenases were discovered 40 years ago and although the enzymes have been well characterized with respect to their structural and functional properties the biological roles of the different lipoxygenase isoforms are not completely understood. This review is aimed at summarizing the current knowledge on the physiological roles of different mammalian LOX-isoforms and their patho-physiological function in inflammatory, metabolic, hyperproliferative, neurodegenerative and infectious disorders. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance". Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Viruses and the nucleolus: the fatal attraction.

    PubMed

    Salvetti, Anna; Greco, Anna

    2014-06-01

    Viruses are small obligatory parasites and as a consequence, they have developed sophisticated strategies to exploit the host cell's functions to create an environment that favors their own replication. A common feature of most - if not all - families of human and non-human viruses concerns their interaction with the nucleolus. The nucleolus is a multifunctional nuclear domain, which, in addition to its well-known role in ribosome biogenesis, plays several crucial other functions. Viral infection induces important nucleolar alterations. Indeed, during viral infection numerous viral components localize in nucleoli, while various host nucleolar proteins are redistributed in other cell compartments or are modified, and non-nucleolar cellular proteins reach the nucleolus. This review highlights the interactions reported between the nucleolus and some human or animal viral families able to establish a latent or productive infection, selected on the basis of their known interactions with the nucleolus and the nucleolar activities, and their links with virus replication and/or pathogenesis. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Modulation of low-voltage-activated T-type Ca²⁺ channels.

    PubMed

    Zhang, Yuan; Jiang, Xinghong; Snutch, Terrance P; Tao, Jin

    2013-07-01

    Low-voltage-activated T-type Ca²⁺ channels contribute to a wide variety of physiological functions, most predominantly in the nervous, cardiovascular and endocrine systems. Studies have documented the roles of T-type channels in sleep, neuropathic pain, absence epilepsy, cell proliferation and cardiovascular function. Importantly, novel aspects of the modulation of T-type channels have been identified over the last few years, providing new insights into their physiological and pathophysiological roles. Although there is substantial literature regarding modulation of native T-type channels, the underlying molecular mechanisms have only recently begun to be addressed. This review focuses on recent evidence that the Ca(v)3 subunits of T-type channels, Ca(v)3.1, Ca(v)3.2 and Ca(v)3.3, are differentially modulated by a multitude of endogenous ligands including anandamide, monocyte chemoattractant protein-1, endostatin, and redox and oxidizing agents. The review also provides an overview of recent knowledge gained concerning downstream pathways involving G-protein-coupled receptors. This article is part of a Special Issue entitled: Calcium channels. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue.

    PubMed

    Lam, Maggie P Y; Scruggs, Sarah B; Kim, Tae-Young; Zong, Chenggong; Lau, Edward; Wang, Ding; Ryan, Christopher M; Faull, Kym F; Ping, Peipei

    2012-08-03

    The regulation of mitochondrial function is essential for cardiomyocyte adaptation to cellular stress. While it has long been understood that phosphorylation regulates flux through metabolic pathways, novel phosphorylation sites are continually being discovered in all functionally distinct areas of the mitochondrial proteome. Extracting biologically meaningful information from these phosphorylation sites requires an adaptable, sensitive, specific and robust method for their quantification. Here we report a multiple reaction monitoring-based mass spectrometric workflow for quantifying site-specific phosphorylation of mitochondrial proteins. Specifically, chromatographic and mass spectrometric conditions for 68 transitions derived from 23 murine and human phosphopeptides, and their corresponding unmodified peptides, were optimized. These methods enabled the quantification of endogenous phosphopeptides from the outer mitochondrial membrane protein VDAC, and the inner membrane proteins ANT and ETC complexes I, III and V. The development of this quantitative workflow is a pivotal step for advancing our knowledge and understanding of the regulatory effects of mitochondrial protein phosphorylation in cardiac physiology and pathophysiology. This article is part of a Special Issue entitled: Translational Proteomics. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Building a patchwork - The yeast plasma membrane as model to study lateral domain formation.

    PubMed

    Schuberth, Christian; Wedlich-Söldner, Roland

    2015-04-01

    The plasma membrane (PM) has to fulfill a wide range of biological functions including selective uptake of substances, signal transduction and modulation of cell polarity and cell shape. To allow efficient regulation of these processes many resident proteins and lipids of the PM are laterally segregated into different functional domains. A particularly striking example of lateral segregation has been described for the budding yeast PM, where integral membrane proteins as well as lipids exhibit very slow translational mobility and form a patchwork of many overlapping micron-sized domains. Here we discuss the molecular and physical mechanisms contributing to the formation of a multi-domain membrane and review our current understanding of yeast PM organization. Many of the fundamental principles underlying membrane self-assembly and organization identified in yeast are expected to equally hold true in other organisms, even for the more transient and elusive organization of the PM in mammalian cells. This article is part of a Special Issue entitled: Nanoscale membrane organisation and signalling. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. The impact of proteomics on the understanding of functions and biogenesis of fungal extracellular vesicles.

    PubMed

    Rodrigues, Marcio L; Nakayasu, Ernesto S; Almeida, Igor C; Nimrichter, Leonardo

    2014-01-31

    Several microbial molecules are released to the extracellular space in vesicle-like structures. In pathogenic fungi, these molecules include pigments, polysaccharides, lipids, and proteins, which traverse the cell wall in vesicles that accumulate in the extracellular space. The diverse composition of fungal extracellular vesicles (EV) is indicative of multiple mechanisms of cellular biogenesis, a hypothesis that was supported by EV proteomic studies in a set of Saccharomyces cerevisiae strains with defects in both conventional and unconventional secretory pathways. In the human pathogens Cryptococcus neoformans, Histoplasma capsulatum, and Paracoccidioides brasiliensis, extracellular vesicle proteomics revealed the presence of proteins with both immunological and pathogenic activities. In fact, fungal EV have been demonstrated to interfere with the activity of immune effector cells and to increase fungal pathogenesis. In this review, we discuss the impact of proteomics on the understanding of functions and biogenesis of fungal EV, as well as the potential role of these structures in fungal pathogenesis. This article is part of a Special Issue entitled: Trends in Microbial Proteomics. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Power increases the socially toxic component of narcissism among individuals with high baseline testosterone.

    PubMed

    Mead, Nicole L; Baumeister, Roy F; Stuppy, Anika; Vohs, Kathleen D

    2018-04-01

    The corrosive effects of power have been noted for centuries, but the self-related changes responsible for those effects have remained somewhat elusive. Narcissists tend to rise to-and abuse-positions of power, so we considered the possibility that positions of power may corrupt because they inflate narcissism. Two pathways were considered: Powerholders abuse their power because having power over others makes them feel superior (grandiosity pathway) or deserving of special treatment (entitlement pathway). Supporting the entitlement pathway, assigning participants to a position of power (vs. equal control) over a group task increased scores on the Exploitative/Entitlement component of narcissism among those with high baseline testosterone. What is more, heightened Exploitative/Entitlement scores among high-testosterone participants endowed with power (vs. equal control) statistically explained amplified self-reported willingness to misuse their power (e.g., taking fringe benefits as extra compensation). The grandiosity pathway was not well supported. The Superiority/Arrogance, Self-Absorption/Self-Admiration, and Leadership/Authority facets of narcissism did not change as a function of the power manipulation and testosterone levels. Taken together, these results suggest that people with high (but not low) testosterone may be inclined to misuse their power because having power over others makes them feel entitled to special treatment. This work identifies testosterone as a characteristic that contributes to the development of the socially toxic component of narcissism (Exploitative/Entitlement). It points to the possibility that structural positions of power and individual differences in narcissism may be mutually reinforcing, suggesting a vicious cycle with personal, relational, and societal implications. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  20. Income-related inequity in the use of GP services by children: a comparison of Ireland and Scotland.

    PubMed

    Layte, Richard; Nolan, Anne

    2015-06-01

    Equity of access to health care is a key component of national and international health policy, with most countries subscribing to the principle that health care should be allocated on the basis of need, rather than ability to pay or other criteria. The issue of health care entitlements for children is particularly pertinent given the strong causal links that have been demonstrated between eligibility for free care, utilisation and health outcomes. The Irish health care system is unusual in requiring the majority of the population to pay the full out-of-pocket cost of GP care. In contrast, all Scottish residents are entitled to free GP care at the point of use. This difference in public health care entitlements between Ireland and Scotland allows us to examine the impact of differences in financing structures on equity in GP care. In this paper, we use data from two nationally representative surveys of children in Ireland and Scotland to examine the degree of income-related inequity in the utilisation of GP services in both countries. We find that while the distribution of GP care is significantly pro-poor in Ireland, even after adjustment for health need, there is little or no significant inequity in GP utilisation among Scottish children. However, focusing just on children who pay the full price of GP care in Ireland, we find some evidence for a significant pro-rich distribution of GP visits. These results reflect the particular structure of health care entitlements that exist in two systems.

  1. Membrane composition and dynamics: a target of bioactive virgin olive oil constituents.

    PubMed

    Lopez, Sergio; Bermudez, Beatriz; Montserrat-de la Paz, Sergio; Jaramillo, Sara; Varela, Lourdes M; Ortega-Gomez, Almudena; Abia, Rocio; Muriana, Francisco J G

    2014-06-01

    The endogenous synthesis of lipids, which requires suitable dietary raw materials, is critical for the formation of membrane bilayers. In eukaryotic cells, phospholipids are the predominant membrane lipids and consist of hydrophobic acyl chains attached to a hydrophilic head group. The relative balance between saturated, monounsaturated, and polyunsaturated acyl chains is required for the organization and normal function of membranes. Virgin olive oil is the richest natural dietary source of the monounsaturated lipid oleic acid and is one of the key components of the healthy Mediterranean diet. Virgin olive oil also contains a unique constellation of many other lipophilic and amphipathic constituents whose health benefits are still being discovered. The focus of this review is the latest evidence regarding the impact of oleic acid and the minor constituents of virgin olive oil on the arrangement and behavior of lipid bilayers. We highlight the relevance of these interactions to the potential use of virgin olive oil in preserving the functional properties of membranes to maintain health and in modulating membrane functions that can be altered in several pathologies. This article is part of a Special Issue entitled: Membrane Structure and Function: Relevance in the Cell's Physiology, Pathology and Therapy. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Glutathione transferases, regulators of cellular metabolism and physiology.

    PubMed

    Board, Philip G; Menon, Deepthi

    2013-05-01

    The cytosolic glutathione transferases (GSTs) comprise a super family of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions. The review covers the genetics, structure and function of the human cytosolic GSTs with particular attention to their emerging roles in cellular metabolism. All the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine. An increasing body of work has implicated several GSTs in the regulation of cell signaling pathways mediated by stress-activated kinases like Jun N-terminal kinase. In addition, some members of the cytosolic GST family have been shown to form ion channels in intracellular membranes and to modulate ryanodine receptor Ca(2+) channels in skeletal and cardiac muscle. In addition to their well established roles in the conjugation and biotransformation of xenobiotics, GSTs have emerged as significant regulators of pathways determining cell proliferation and survival and as regulators of ryanodine receptors that are essential for muscle function. This article is part of a Special Issue entitled Cellular functions of glutathione. Copyright © 2012 Elsevier B.V. All rights reserved.

  3. Tangled web of interactions among proteins involved in iron–sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies☆

    PubMed Central

    Kim, Jin Hae; Bothe, Jameson R.; Alderson, T. Reid; Markley, John L.

    2014-01-01

    Proteins containing iron–sulfur (Fe–S) clusters arose early in evolution and are essential to life. Organisms have evolved machinery consisting of specialized proteins that operate together to assemble Fe–S clusters efficiently so as to minimize cellular exposure to their toxic constituents: iron and sulfide ions. To date, the best studied system is the iron sulfur cluster (isc) operon of Escherichia coli, and the eight ISC proteins it encodes. Our investigations over the past five years have identified two functional conformational states for the scaffold protein (IscU) and have shown that the other ISC proteins that interact with IscU prefer to bind one conformational state or the other. From analyses of the NMR spectroscopy-derived network of interactions of ISC proteins and small-angle X-ray scattering (SAXS), chemical crosslinking experiments, and functional assays, we have constructed working models for Fe–S cluster assembly and delivery. Future work is needed to validate and refine what has been learned about the E. coli system and to extend these findings to the homologous Fe–S cluster biosynthetic machinery of yeast and human mitochondria. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases. PMID:25450980

  4. Teacher Resource Book for Population Pressure in Indonesia, Problems of Industrialization in Eurasia, Power Blocs in Eurasia. Man on the Earth Series.

    ERIC Educational Resources Information Center

    Gunn, Angus

    This teacher's resource book is a guide to three intermediate texts about Eurasia entitled Population Pressure in Indonesia, Problems of Industrialization in Eurasia, and Power Blocs in Eurasia. The texts are part of the series, Man on the Earth, which probes broad-based issues confronting mankind. The resource book distinguishes 18 major concepts…

  5. 77 FR 70168 - Guidance for Industry and Food and Drug Administration Staff; The Content of Investigational...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ...The Food and Drug Administration (FDA) is announcing the availability of the guidance entitled ``The Content of Investigational Device Exemption (IDE) and Premarket Approval (PMA) Applications for Artificial Pancreas Device Systems.'' FDA is issuing this guidance to inform industry and Agency staff of its recommendations for analytical and clinical performance studies to support premarket submissions for artificial pancreas systems.

  6. A Misleading Review of Response Bias: Comment on McGrath, Mitchell, Kim, and Hough (2010)

    ERIC Educational Resources Information Center

    Rohling, Martin L.; Larrabee, Glenn J.; Greiffenstein, Manfred F.; Ben-Porath, Yossef S.; Lees-Haley, Paul; Green, Paul; Greve, Kevin W.

    2011-01-01

    In the May 2010 issue of "Psychological Bulletin," R. E. McGrath, M. Mitchell, B. H. Kim, and L. Hough published an article entitled "Evidence for Response Bias as a Source of Error Variance in Applied Assessment" (pp. 450-470). They argued that response bias indicators used in a variety of settings typically have insufficient data to support such…

  7. PTC'85: Toward a Digital World. Telecommunications for Pacific Development. Proceedings of the Annual Conference of the Pacific Telecommunications Council (7th, Honolulu, HI, January 13-16, 1985).

    ERIC Educational Resources Information Center

    Wedemeyer, Dan J., Ed.

    More than 60 papers in this conference proceedings address telecommunications issues in the Pacific region, specifically focusing on the development, use, implementation, and management of new digital communications channels. Following a keynote address on the political and economic realities in the Pacific, entitled "Progress Report on the…

  8. Environmental Studies: A High School Course for Each Citizen, of Each Town, in South Carolina, U.S.A.

    ERIC Educational Resources Information Center

    Alsbrooks, Ann; And Others

    This is a complete environmental studies course for high schools. It may be used as a year-long elective, a semester course, or infused by individual units into science, social studies, health, or other courses. The course is composed of thirteen separate units entitled: (1) Investigating Environmental Problems and Issues; (2) Energy; (3) Water;…

  9. A Contextual-Functional Meta-Framework for Counselling Supervision

    ERIC Educational Resources Information Center

    Chang, Jeff

    2013-01-01

    In this paper, an approach to clinical supervision, entitled the Contextual-Functional Meta-Framework (CFM), is developed and articulated, based on a consideration of current literature and the author's extensive practice experience. First, the context for the development of the CFM, and its formative influences, are examined, followed by a review…

  10. Can Particulate Pollution Affect Lung Function in Healthy Adults?

    EPA Science Inventory

    Accompanying editorial to paper from Harvard by Rice et al. entitled "Long-Term Exposure to Traffic Emissions and Fine Particulate Matter and Lung Function Decline in the Framingham Heart StudyBy almost any measure the Clean Air Act and its amendments has to be considered as one...

  11. 76 FR 20821 - Proposed Information Collection (Disabled Veterans Application for Vocational Rehabilitation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... necessary for the proper performance of VBA's functions, including whether the information will have... entitlement determination, to gain and keep suitable employment. Vocational rehabilitation also provides...

  12. Academic Entitlement and Academic Performance in Graduating Pharmacy Students

    PubMed Central

    Barclay, Sean M.; Stolte, Scott K.

    2014-01-01

    Objectives. To determine a measurable definition of academic entitlement, measure academic entitlement in graduating doctor of pharmacy (PharmD) students, and compare the academic performance between students identified as more or less academically entitled. Methods. Graduating students at a private health sciences institution were asked to complete an electronic survey instrument that included demographic data, academic performance, and 2 validated academic entitlement instruments. Results. One hundred forty-one of 243 students completed the survey instrument. Fourteen (10%) students scored greater than the median total points possible on 1 or both of the academic entitlement instruments and were categorized as more academically entitled. Less academically entitled students required fewer reassessments and less remediation than more academically entitled students. The highest scoring academic entitlement items related to student perception of what professors should do for them. Conclusion. Graduating pharmacy students with lower levels of academic entitlement were more academically successful than more academically entitled students. Moving from an expert opinion approach to evidence-based decision-making in the area of academic entitlement will allow pharmacy educators to identify interventions that will decrease academic entitlement and increase academic success in pharmacy students. PMID:25147388

  13. Preface to "Insights into the Earth's Deep Lithosphere"

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pasyanos, M E

    Dear Readers: I am pleased to present a special issue of Tectonophysics entitled 'Insights into the Earth's Deep Lithosphere.' This compilation sought to capture the flavor of the increasing number of studies that are emerging to investigate the complex lithospheric structure of the earth. This issue evolved out of a Fall 2007 AGU special session entitled 'Understanding the Earth's Deep Lithosphere' that I organized with Irina Artemieva from the University of Copenhagen. For that session, we solicited talks that discussed the increasing number of methods that have surfaced to study various aspects of the earth's deep lithosphere. These methods includemore » seismic, gravity, thermal, geochemical, and various combinations of these methods. The quality of the presentations (2 oral sessions with 16 talks and 23 associated poster presentations) was such that we felt that the emerging topic deserved a dedicated forum to address these questions in greater detail. The availability of new data sets has also improved the number and quality of lithospheric studies. With many new studies and methodologies, a better understanding of both continental and oceanic lithospheres is starting to emerge. Questions remain about the thickness and evolution of the lithosphere, the presence of lithospheric keels, the density and anisotropy of lithospheric roots, mechanisms of lithospheric thinning, and differences between mechanical, thermal and chemical boundary layers. While we did not get contributions on the full gamut of methods and regions, a lot of ground was covered in this issue's manuscripts. Like any collection of papers on the deep lithosphere, the topics are quite varied in methodology, geographic location, and what aspect of the lithosphere being studied. Still, the results highlight the rewarding aspects of earth structure, history, and evolution that can be gleaned. A brief synopsis of the papers contained in this issue is given.« less

  14. Doxycycline Compliance at Bagram Air Field

    DTIC Science & Technology

    2014-05-01

    doxycycline absorption. In 2008, the Institute of Medicine issued a report entitled ·’Use of Dietary Supplements by Military Personnel" that reported 34...absorption by tetracycline. Br J Clin Pharmacal. 1975 February; 2(1): 94- 96. 19. 0. M. e. Greenwood MRC, "Use of Dietary Supplements by Military...Personnel.Institute of Medicine (US) Committee on Dietary Supplement Use by Military Personnel," National Academies Press, Washington (DC), 2008. 20

  15. An Alternative Way of Responding to Powerful Ideas: Notes to Accompany the Poem Entitled "Five Principles of Quality in Narratives of Action Research"

    ERIC Educational Resources Information Center

    Saunders, Lesley

    2007-01-01

    This paper is written in a personal capacity and mainly takes the form of a poem--in five sections--composed as a response to some of the ideas in the article by Hannu Heikkinen and colleagues in this same issue of "Educational Action Research": "Action research as narrative: five principles for validation". The poem takes its…

  16. Traumatic Brain Injury Recovery Care: Demand Forecasting Staffing, and Treatment Planning

    DTIC Science & Technology

    2013-03-21

    order to provide service to more wounded, ill and injured ( WII ), while continuing to provide a high quality and valuable service. There are...These wounded, ill, or injured ( WII ) troops will be diagnosed and receive treatment at specialty clinics. Once they have completed the necessary...most issues arising with military pay, benefits, entitlements, transition to civilian at medical board , etc. The RCP handles the medical treatment

  17. Block-Time Classes and the Core Program in the Junior High School. Bulletin, 1958, No. 6

    ERIC Educational Resources Information Center

    Wright, Grace S.

    1958-01-01

    By this study, as by several it has issued in the past few years the Office of Education recognizes the interest of many educators in the core program as a means of achieving some of the objectives of general education at the secondary level. Its first publication, Bulletin 1950, No. 5 entitled "Core Curriculum in Public High Schools," a study of…

  18. Neuro-Holistic Learning©: An Integrated Kinesthetic Approach to Cognitive Learning© Using Collaborative Interactive Thought Exchange© in a Blended Environment to Enhance the Learning of Young African American Males

    ERIC Educational Resources Information Center

    Osler, James Edward, II; Wright, Mark Anthony

    2016-01-01

    This paper is part two of the article entitled, "Dynamic Neuroscientific Systemology: Using Tri-Squared Meta-Analysis and Innovative Instructional Design to Develop a Novel Distance Education Model for the Systemic Creation of Engaging Online Learning Environments" published in the July-September 2015 issue of i-manager's "Journal…

  19. Federal policies to promote the widespread utilization of photovoltaic systems. Supplement: Review and critique

    NASA Technical Reports Server (NTRS)

    Smith, J. L.

    1980-01-01

    Review comments of the Congressional report entitled 'Federal Policies to Promote the Widespread Utilization of Photovoltaic Systems' are presented. Responses to the review comments by the Jet Propulsion Laboratory, preparer of the Congressional report, are also presented. The Congressional report discussed various issues related to promoting the deployment of photovoltaic systems through the Federal Photovoltaic Program. Various program strategies and funding levels were examined.

  20. Mexico-U.S. Relations: Issues for Congress

    DTIC Science & Technology

    2009-04-14

    highways beyond the commercial zone. Sugar and High Fructose Corn Syrup The United States and Mexico resolved a long standing trade dispute involving...sugar and high fructose corn syrup in 2006. Mexico argued that the sugar side letter negotiated under NAFTA entitled it to ship net sugar surplus to...complained that imports of high fructose corn syrup (HFCS) sweeteners from the United States constituted dumping, and it imposed anti-dumping duties

  1. Workshop in computational molecular biology, April 15, 1991--April 14, 1994

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tavare, S.

    Funds from this award were used to the Workshop in Computational Molecular Biology, `91 Symposium entitled Interface: Computing Science and Statistics, Seattle, Washington, April 21, 1991; the Workshop in Statistical Issues in Molecular Biology held at Stanford, California, August 8, 1993; and the Session on Population Genetics a part of the 56th Annual Meeting, Institute of Mathematical Statistics, San Francisco, California, August 9, 1993.

  2. 78 FR 79480 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ...Notice is hereby given that the U.S. International Trade Commission has received a complaint entitled Certain Vision-Based Driver Assistance System Cameras and Components Thereof, DN 2993; the Commission is soliciting comments on any public interest issues raised by the complaint or complainant's filing under section 210.8(b) of the Commission's Rules of Practice and Procedure (19 CFR 210.8(b)).

  3. National Health Expenditures, 1982

    PubMed Central

    Gibson, Robert M.; Waldo, Daniel R.; Levit, Katharine R.

    1983-01-01

    Rapid growth in the share of the nation's gross national product devoted to health expenditure has heightened concern over the survival of government entitlement programs and has led to debate of the desirability of current methods of financing health care. In this article, the authors present the data at the heart of the issue, quantifying spending for various types of health care in 1982 and discussing the sources of funds for that spending. PMID:10310273

  4. First Annual High-Speed Research Workshop, part 1

    NASA Technical Reports Server (NTRS)

    Whitehead, Allen H., Jr. (Compiler)

    1992-01-01

    The workshop was presented to provide a national forum for the government, industry, and university participants in the program to present and discuss important technology issues related to the development of a commercially viable, environmentally compatible U.S. High Speed Civil Transport. The workshop sessions were organized around the major task elements in NASA's Phase 1 High Speed Research Program which basically addressed the environmental issues of atmospheric emissions, community noise, and sonic boom. This volume is divided into three sessions entitled: Plenary Session (which gives overviews from NASA, Boeing, Douglas, GE, and Pratt & Whitney on the HSCT program); Airframe Systems Studies; and Atmospheric Effects.

  5. Preface: Special Topic: From Quantum Mechanics to Force Fields.

    PubMed

    Piquemal, Jean-Philip; Jordan, Kenneth D

    2017-10-28

    This Special Topic issue entitled "From Quantum Mechanics to Force Fields" is dedicated to the ongoing efforts of the theoretical chemistry community to develop a new generation of accurate force fields based on data from high-level electronic structure calculations and to develop faster electronic structure methods for testing and designing force fields as well as for carrying out simulations. This issue includes a collection of 35 original research articles that illustrate recent theoretical advances in the field. It provides a timely snapshot of recent developments in the generation of approaches to enable more accurate molecular simulations of processes important in chemistry, physics, biophysics, and materials science.

  6. History of the Tinnitus Research Consortium.

    PubMed

    Snow, James B

    2016-04-01

    This article describes the creation and accomplishments of the Tinnitus Research Consortium (TRC), founded and supported through philanthropy and intended to enrich the field of tinnitus research. Bringing together a group of distinguished auditory researchers, most of whom were not involved in tinnitus research, over the fifteen years of its life it developed novel research approaches and recruited a number of new investigators into the field. The purpose of this special issue is to highlight some of the significant accomplishments of the investigators supported by the TRC. This article is part of a Special Issue entitled "Tinnitus". Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Preface: Special Topic: From Quantum Mechanics to Force Fields

    NASA Astrophysics Data System (ADS)

    Piquemal, Jean-Philip; Jordan, Kenneth D.

    2017-10-01

    This Special Topic issue entitled "From Quantum Mechanics to Force Fields" is dedicated to the ongoing efforts of the theoretical chemistry community to develop a new generation of accurate force fields based on data from high-level electronic structure calculations and to develop faster electronic structure methods for testing and designing force fields as well as for carrying out simulations. This issue includes a collection of 35 original research articles that illustrate recent theoretical advances in the field. It provides a timely snapshot of recent developments in the generation of approaches to enable more accurate molecular simulations of processes important in chemistry, physics, biophysics, and materials science.

  8. Corrigendum to ;On the computation of the multidimensional Mittag-Leffler function; [Commun. Nonlinear Sci. Numer. Simulat. 53 (2017) 278-287

    NASA Astrophysics Data System (ADS)

    Ortigueira, Manuel D.; Lopes, António M.; Machado, J. A. Tenreiro

    2018-02-01

    In the paper entitled "On the computation of the multidimensional Mittag-Leffler function" there is an error that originates some misleading nomenclature and results. The phrase in Section 2, page 2, three lines after equation (4), should be written as follows:

  9. Development and Evaluation of the SUMIT Microcomputer Module Entitled 'Predator Functional Response'.

    ERIC Educational Resources Information Center

    Shaltz, Mark B.

    An experiment was conducted that compared the teaching effectiveness of a computer assisted instructional module and a lecture-discussion. The module, Predator Functional Response (PFR), was developed as part of the SUMIT (Single-concept User-adaptable Microcomputer-based Instructional Technique) project. A class of 30 students was randomly…

  10. The early days of the multi channel cochlear implant: efforts and achievement in France.

    PubMed

    Chouard, C H

    2015-04-01

    On September 10th 2013, the clinical medical research Lasker award winners were rewarded for their work on multichannel cochlear implant. It has been my pleasure to see that such a major topic had caught the attention of the Members of the Jury for this prestigious award. That is why I accepted an invitation to participate in a special issue of Hearing Research devoted to the three winners. Here I highlight four scientific contributions made by the French team in late 1970s and early 1980s to modern multichannel cochlear implant development. 1) Chouard and MacLeod plotted an approximate frequency map of the whole length of the human cochlea, including its "hidden face" corresponding to speech frequencies. Moreover MacLeod suggested a sequential display of electrical stimulation as a function of each electrode, a precursor to today's electrodogram and interleaved stimulation. 2) Chouard performed total cochlear implantation in a deaf adult male with 8 electrically independent electrodes that were evenly distributed along the cochlea. 3) Chouard and MacLeod described in a patent detailed sound signal processing for a functional multichannel cochlear implant and reported speech discrimination without help of lip reading in some totally deafened patients. 4) Chouard experimentally demonstrated in the guinea pig the advantage of early cochlear implantation in treating profound neonatal deafness. This article is part of a Special Issue entitled . Copyright © 2014 Elsevier B.V. All rights reserved.

  11. 10 CFR 51.68 - Environmental report-rulemaking.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing... special nuclear material shall submit with the petition a separate document entitled “Petitioner's...

  12. Skeletal muscle mitochondria: a major player in exercise, health and disease.

    PubMed

    Russell, Aaron P; Foletta, Victoria C; Snow, Rod J; Wadley, Glenn D

    2014-04-01

    Maintaining skeletal muscle mitochondrial content and function is important for sustained health throughout the lifespan. Exercise stimulates important key stress signals that control skeletal mitochondrial biogenesis and function. Perturbations in mitochondrial content and function can directly or indirectly impact skeletal muscle function and consequently whole-body health and wellbeing. This review will describe the exercise-stimulated stress signals and molecular mechanisms positively regulating mitochondrial biogenesis and function. It will then discuss the major myopathies, neuromuscular diseases and conditions such as diabetes and ageing that have dysregulated mitochondrial function. Finally, the impact of exercise and potential pharmacological approaches to improve mitochondrial function in diseased populations will be discussed. Exercise activates key stress signals that positively impact major transcriptional pathways that transcribe genes involved in skeletal muscle mitochondrial biogenesis, fusion and metabolism. The positive impact of exercise is not limited to younger healthy adults but also benefits skeletal muscle from diseased populations and the elderly. Impaired mitochondrial function can directly influence skeletal muscle atrophy and contribute to the risk or severity of disease conditions. Pharmacological manipulation of exercise-induced pathways that increase skeletal muscle mitochondrial biogenesis and function in critically ill patients, where exercise may not be possible, may assist in the treatment of chronic disease. This review highlights our understanding of how exercise positively impacts skeletal muscle mitochondrial biogenesis and function. Exercise not only improves skeletal muscle mitochondrial health but also enables us to identify molecular mechanisms that may be attractive targets for therapeutic manipulation. This article is part of a Special Issue entitled Frontiers of mitochondrial research. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Putting third first: critical legal issues and HIV/AIDS.

    PubMed

    2000-01-01

    On 7 July 2000, before the XIII International AIDS Conference, the Canadian HIV/AIDS Legal Network and the AIDS Law Project, South Africa held a one-day satellite meeting on legal, ethical, and human rights issues in Durban, South Africa. Entitled Putting Third First--Critical Legal Issues and HIV/AIDS, the satellite focused on legal strategies to advance the human rights of those most vulnerable to HIV/AIDS and to discrimination: people in the developing world, and people who, although they live in the industrialized world, suffer from poverty and marginalization and are at high risk of contracting HIV. The satellite grew out of the ongoing partnership between the Canadian HIV/AIDS Legal Network and the AIDS Law Project, South Africa, and was co-hosted by UNAIDS.

  14. Special Issue: "Molecules against Alzheimer".

    PubMed

    Decker, Michael; Muñoz-Torrero, Diego

    2016-12-16

    This Special Issue, entitled "Molecules against Alzheimer", gathers a number of original articles, short communications, and review articles on recent research efforts toward the development of novel drug candidates, diagnostic agents and therapeutic approaches for Alzheimer's disease (AD), the most prevalent neurodegenerative disorder and a leading cause of death worldwide. This Special Issue contains many interesting examples describing the design, synthesis, and pharmacological profiling of novel compounds that hit one or several key biological targets, such as cholinesterases, β-amyloid formation or aggregation, monoamine oxidase B, oxidative stress, biometal dyshomeostasis, mitochondrial dysfunction, serotonin and/or melatonin systems, the Wnt/β-catenin pathway, sigma receptors, nicotinamide phosphoribosyltransferase, or nuclear erythroid 2-related factor. The development of novel AD diagnostic agents based on tau protein imaging and the use of lithium or intranasal insulin for the prevention or the symptomatic treatment of AD is also covered in some articles of the Special Issue.

  15. Effect of posttranslational modifications on enzyme function and assembly.

    PubMed

    Ryšlavá, Helena; Doubnerová, Veronika; Kavan, Daniel; Vaněk, Ondřej

    2013-10-30

    The detailed examination of enzyme molecules by mass spectrometry and other techniques continues to identify hundreds of distinct PTMs. Recently, global analyses of enzymes using methods of contemporary proteomics revealed widespread distribution of PTMs on many key enzymes distributed in all cellular compartments. Critically, patterns of multiple enzymatic and nonenzymatic PTMs within a single enzyme are now functionally evaluated providing a holistic picture of a macromolecule interacting with low molecular mass compounds, some of them being substrates, enzyme regulators, or activated precursors for enzymatic and nonenzymatic PTMs. Multiple PTMs within a single enzyme molecule and their mutual interplays are critical for the regulation of catalytic activity. Full understanding of this regulation will require detailed structural investigation of enzymes, their structural analogs, and their complexes. Further, proteomics is now integrated with molecular genetics, transcriptomics, and other areas leading to systems biology strategies. These allow the functional interrogation of complex enzymatic networks in their natural environment. In the future, one might envisage the use of robust high throughput analytical techniques that will be able to detect multiple PTMs on a global scale of individual proteomes from a number of carefully selected cells and cellular compartments. This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. Vascularisation to improve translational potential of tissue engineering systems for cardiac repair.

    PubMed

    Dilley, Rodney J; Morrison, Wayne A

    2014-11-01

    Cardiac tissue engineering is developing as an alternative approach to heart transplantation for treating heart failure. Shortage of organ donors and complications arising after orthotopic transplant remain major challenges to the modern field of heart transplantation. Engineering functional myocardium de novo requires an abundant source of cardiomyocytes, a biocompatible scaffold material and a functional vasculature to sustain the high metabolism of the construct. Progress has been made on several fronts, with cardiac cell biology, stem cells and biomaterials research particularly promising for cardiac tissue engineering, however currently employed strategies for vascularisation have lagged behind and limit the volume of tissue formed. Over ten years we have developed an in vivo tissue engineering model to construct vascularised tissue from various cell and tissue sources, including cardiac tissue. In this article we review the progress made with this approach and others, together with their potential to support a volume of engineered tissue for cardiac tissue engineering where contractile mass impacts directly on functional outcomes in translation to the clinic. It is clear that a scaled-up cardiac tissue engineering solution required for clinical treatment of heart failure will include a robust vascular supply for successful translation. This article is part of a directed issue entitled: Regenerative Medicine: the challenge of translation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health.

    PubMed

    Ibarguren, Maitane; López, David J; Escribá, Pablo V

    2014-06-01

    This review deals with the effects of synthetic and natural fatty acids on the biophysical properties of membranes, and on their implication on cell function. Natural fatty acids are constituents of more complex lipids, like triacylglycerides or phospholipids, which are used by cells to store and obtain energy, as well as for structural purposes. Accordingly, natural and synthetic fatty acids may modify the structure of the lipid membrane, altering its microdomain organization and other physical properties, and provoking changes in cell signaling. Therefore, by modulating fatty acids it is possible to regulate the structure of the membrane, influencing the cell processes that are reliant on this structure and potentially reverting pathological cell dysfunctions that may provoke cancer, diabetes, hypertension, Alzheimer's and Parkinson's disease. The so-called Membrane Lipid Therapy offers a strategy to regulate the membrane composition through drug administration, potentially reverting pathological processes by re-adapting cell membrane structure. Certain fatty acids and their synthetic derivatives are described here that may potentially be used in such therapies, where the cell membrane itself can be considered as a target to combat disease. This article is part of a Special Issue entitled: Membrane Structure and Function: Relevance in the Cell's Physiology, Pathology and Therapy. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy.

    PubMed

    Allendorfer, Jane B; Szaflarski, Jerzy P

    2017-05-01

    Recent interest for the use of cannabis-derived products as therapeutic agents in the treatment of epilepsies has necessitated a reevaluation of their effects on brain and behavior. Overall, prolonged cannabis use is thought to result in functional and structural brain alterations. These effects may be dependent on a number of factors: e.g., which phytocannabinoid is used (e.g., cannabidiol (CBD) vs. tetrahyrocannabinol (THC)), the frequency of use (occasional vs. heavy), and at what age (prenatal, childhood, adulthood) the use began. However, due to the fact that there are over seven hundred constituents that make up the Cannabis sativa plant, it is difficult to determine which compound or combination of compounds is responsible for specific effects when studying recreational users. Therefore, this review focuses only on the functional MRI studies investigating the effects of specific pharmacological preparations of cannabis compounds, specifically THC, tetrahydrocannabivarin (THCV), and CBD, on brain function in healthy individuals and persons with epilepsy with references to non-epilepsy studies only to underline the gaps in research that need to be filled before cannabis-derived products are considered for a wide use in the treatment of epilepsy. This article is part of a Special Issue entitled "Cannabinoids and Epilepsy". Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Shaping the Future of Mathematics Education. Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia (33rd, Freemantle, Western Australia, Australia, July 3-7, 2010)

    ERIC Educational Resources Information Center

    Sparrow, Len, Ed.; Kissane, Barry, Ed.; Hurst, Chris, Ed.

    2010-01-01

    These collected papers are a record of the proceedings of the 33rd Annual Conference of the Mathematics Education Research Group of Australasia entitled, "Shaping the Future of Mathematics Education." The conference is held in Fremantle, as was the previous conference a decade earlier. Keynote speakers are discussing issues that are emerging more…

  20. 78 FR 35940 - Content of Premarket Submissions for Management of Cybersecurity in Medical Devices; Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ...The Food and Drug Administration (FDA) is announcing the availability of the draft guidance entitled ``Content of Premarket Submissions for Management of Cybersecurity in Medical Devices.'' This guidance identifies cybersecurity issues that manufacturers should consider in preparing premarket submissions for medical devices in order to maintain information confidentiality, integrity, and availability. This draft guidance is not final nor is it in effect at this time.

  1. Major Management Challenges and Program Risks. Department of State

    DTIC Science & Technology

    2001-01-01

    Major Management Challenges and Program Risks Department of StateGAO-01-252 Form SF298 Citation Data Report Date ("DD MON YYYY") 00JAN2001 Report...Type N/A Dates Covered (from... to) ("DD MON YYYY") Title and Subtitle Major Management Challenges and Program Risks Department of State Contract or...special series, first issued in January 1999, entitled the Performance and Accountability Series: Major Management Challenges and Program Risks . In

  2. Major Management Challenges and Program Risks. Department of the Interior

    DTIC Science & Technology

    2001-01-01

    Major Management Challenges and Program Risks Department of the InteriorGAO-01-249 Report Date ("DD MON YYYY") 00JAN2001 Report Type N/A Dates...Covered (from... to) ("DD MON YYYY") Title and Subtitle Major Management Challenges and Program Risks Department of the Interior Contract or Grant...first issued in January 1999, entitled the Performance and Accountability Series: Major Management Challenges and Program Risks . In that series, GAO

  3. Workshop on Production and Uses of Simulated Lunar Materials

    NASA Technical Reports Server (NTRS)

    1991-01-01

    A workshop entitled, Production and Uses of Simulated Lunar Materials, was convened to define the need for simulated lunar materials and examine related issues in support of extended space exploration and development. Lunar samples are a national treasure and cannot be sacrificed in sufficient quantity to test lunar resource utilization process adequately. Hence, the workshop focused on a detailed examination of the variety of potential simulants and the methods for their production.

  4. De-radicalization: You Can Check Out Anytime You Like, But What Will Make You Leave

    DTIC Science & Technology

    2010-12-01

    comes to describing individual motivations, Abraham Maslow captures the essence of the issue in a 1943 paper entitled A Theory of Human Motivation...behavior until they are fulfilled to a basic degree. 3 Abraham Maslow , "A Theory of Human...Human: A Biography of Abraham Maslow , succinctly described the premise of self-actualization, “In the core of our being we each carry the seed of our

  5. Information Resources Management: Systems Communicating with Systems. A Session Especially Designed by Senior Managers for Senior Management Officials. Viewgraphs and Presentations. Intensive One-Day Symposium (Gaithersburg, Maryland, December 3, 1987).

    ERIC Educational Resources Information Center

    General Services Administration, Washington, DC.

    Summaries of the welcoming and opening remarks for a symposium on the standards issues that will affect the federal government's planning, acquisition, and use of integrated computer and telecommunications systems over the next five years set the stage for the keynote address by Joseph Timko of IBM entitled "Standards--Perspectives and Evolution."…

  6. Mexico-U.S. Relations: Issues for Congress

    DTIC Science & Technology

    2009-05-13

    zone. Sugar and High Fructose Corn Syrup The United States and Mexico resolved a long standing trade dispute involving sugar and high fructose ... high fructose corn syrup (HFCS) sweeteners from the United States constituted dumping, and it imposed anti-dumping duties for some time, until NAFTA... corn syrup in 2006. Mexico argued that the sugar side letter negotiated under NAFTA entitled it to ship net sugar surplus to the United States duty free

  7. Stressing on the nucleolus in cardiovascular disease.

    PubMed

    Hariharan, Nirmala; Sussman, Mark A

    2014-06-01

    The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. © 2013.

  8. The Roles of Science and Technology in General and Continuing Education. Proceedings of the Conference of the Association of American Colleges (Washington, District of Columbia, December 16-18, 1979).

    ERIC Educational Resources Information Center

    Association of American Colleges, Washington, DC.

    This conference focused on issues and topics related to the roles of science and technology in general and continuing education. The keynote address is entitled "Technology Transfer to the Third World: The Critical U.S. Challenge for the Eighties" (William Eilers). The section on perspectives on the public understanding of science includes the…

  9. The Development of Children's Understanding of Distant Places and Environmental Issues: Report of a UK Longitudinal Study of the Development of Ideas between the Ages of 4 and 10 Years

    ERIC Educational Resources Information Center

    Palmer, Joy A.; Suggate, Jennifer

    2004-01-01

    The research reported here forms part of a major international study entitled "Emergent Environmentalism". The overall purpose of the Emergent Environmentalism research is to investigate the acquisition and development of environmental knowledge, awareness and concern in both adults and young children. This report is of the results of one aspect…

  10. Maritime Territorial and Exclusive Economic Zone (EEZ) Disputes Involving China: Issues for Congress

    DTIC Science & Technology

    2016-04-01

    lines from which the breadth of maritime entitlements are measured ) that are inconsistent with international law, including Vietnam and China, and...committed to pursue an arrangement whose intended purpose is equivalent to the Rules of Behavior Confidence Building Measure annex on surface-to-surface...International Studies), February 4, 2015; Mira Rapp-Hooper, “What’s in a Confidence Building Measure ?” Lawfare, February 8, 2015; Peter Dutton and

  11. Biopores/membrane proteins in synthetic polymer membranes.

    PubMed

    Garni, Martina; Thamboo, Sagana; Schoenenberger, Cora-Ann; Palivan, Cornelia G

    2017-04-01

    Mimicking cell membranes by simple models based on the reconstitution of membrane proteins in lipid bilayers represents a straightforward approach to understand biological function of these proteins. This biomimetic strategy has been extended to synthetic membranes that have advantages in terms of chemical and mechanical stability, thus providing more robust hybrid membranes. We present here how membrane proteins and biopores have been inserted both in the membrane of nanosized and microsized compartments, and in planar membranes under various conditions. Such bio-hybrid membranes have new properties (as for example, permeability to ions/molecules), and functionality depending on the specificity of the inserted biomolecules. Interestingly, membrane proteins can be functionally inserted in synthetic membranes provided these have appropriate properties to overcome the high hydrophobic mismatch between the size of the biomolecule and the membrane thickness. Functional insertion of membrane proteins and biopores in synthetic membranes of compartments or in planar membranes is possible by an appropriate selection of the amphiphilic copolymers, and conditions of the self-assembly process. These hybrid membranes have new properties and functionality based on the specificity of the biomolecules and the nature of the synthetic membranes. Bio-hybrid membranes represent new solutions for the development of nanoreactors, artificial organelles or active surfaces/membranes that, by further gaining in complexity and functionality, will promote translational applications. This article is part of a Special Issue entitled: Lipid order/lipid defects and lipid-control of protein activity edited by Dirk Schneider. Copyright © 2016. Published by Elsevier B.V.

  12. A course designed for undergraduate biochemistry students to learn about cultural diversity issues.

    PubMed

    Benore-Parsons, Marilee

    2006-09-01

    Biology, biochemistry, and other science students are well trained in science and familiar with how to conduct and evaluate scientific experiments. They are less aware of cultural issues or how these will impact their careers in research, education, or as professional health care workers. A course was developed for advanced undergraduate science majors to learn about diversity issues in a context that would be relevant to them, entitled "Diversity Issues in Health Care: Treatment and Research." Learning objectives included: developing awareness of current topics concerning diversity issues in health care; learning how research is carried out in health care, including pharmaceutical research, clinical trials, and social research; and learning about health care practices. Lectures and projects included readings on laboratory and clinical research, as well as literature on legal, race, gender, language, age, and income issues in health care research and clinical practice. Exams, papers, and a service learning project were used to determine the final course grade. Assessment indicated student understanding of diversity issues was improved, and the material was relevant. Copyright © 2006 International Union of Biochemistry and Molecular Biology, Inc.

  13. Bottomland Hardwoods of the Mississippi Alluvial Valley: Characteristics and Management of Natural Function, Structure, and Composition

    Treesearch

    Paul B. Hamel; Thomas L. Foti; [Editors

    2001-01-01

    A symposium entitled "Bottomland hardwoods of the Mississippi Alluvial Valley: characteristics and management of natural function, structure, and composition" convened on October 28, 1995, as part of the Natural Areas Conference, October 25-28, 1995, In Fayetteville, AR. The symposium's goal was to provide informatibn that managers need to begin...

  14. 38 CFR 21.9570 - Transfer of entitlement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Transfer of entitlement... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill Transfer of Entitlement to Basic Educational Assistance to Dependents § 21.9570 Transfer of entitlement. An individual entitled to educational...

  15. 38 CFR 21.9570 - Transfer of entitlement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Transfer of entitlement... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill Transfer of Entitlement to Basic Educational Assistance to Dependents § 21.9570 Transfer of entitlement. An individual entitled to educational...

  16. 38 CFR 21.9570 - Transfer of entitlement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Transfer of entitlement... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill Transfer of Entitlement to Basic Educational Assistance to Dependents § 21.9570 Transfer of entitlement. An individual entitled to educational...

  17. 38 CFR 21.9570 - Transfer of entitlement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Transfer of entitlement... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill Transfer of Entitlement to Basic Educational Assistance to Dependents § 21.9570 Transfer of entitlement. An individual entitled to educational...

  18. The function of BDNF in the adult auditory system.

    PubMed

    Singer, Wibke; Panford-Walsh, Rama; Knipper, Marlies

    2014-01-01

    The inner ear of vertebrates is specialized to perceive sound, gravity and movements. Each of the specialized sensory organs within the cochlea (sound) and vestibular system (gravity, head movements) transmits information to specific areas of the brain. During development, brain-derived neurotrophic factor (BDNF) orchestrates the survival and outgrowth of afferent fibers connecting the vestibular organ and those regions in the cochlea that map information for low frequency sound to central auditory nuclei and higher-auditory centers. The role of BDNF in the mature inner ear is less understood. This is mainly due to the fact that constitutive BDNF mutant mice are postnatally lethal. Only in the last few years has the improved technology of performing conditional cell specific deletion of BDNF in vivo allowed the study of the function of BDNF in the mature developed organ. This review provides an overview of the current knowledge of the expression pattern and function of BDNF in the peripheral and central auditory system from just prior to the first auditory experience onwards. A special focus will be put on the differential mechanisms in which BDNF drives refinement of auditory circuitries during the onset of sensory experience and in the adult brain. This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. A Typology of Students Based on Academic Entitlement

    ERIC Educational Resources Information Center

    Luckett, Michael; Trocchia, Philip J.; Noel, Noel Mark; Marlin, Dan

    2017-01-01

    Two hundred ninety-three university business students were surveyed using an academic entitlement (AE) scale updated to include new technologies. Using factor analysis, three components of AE were identified: grade entitlement, behavioral entitlement, and service entitlement. A k-means clustering procedure was then applied to identify four groups…

  20. Cross-talk between GPER and growth factor signaling.

    PubMed

    Lappano, Rosamaria; De Marco, Paola; De Francesco, Ernestina Marianna; Chimento, Adele; Pezzi, Vincenzo; Maggiolini, Marcello

    2013-09-01

    G protein-coupled receptors (GPCRs) and growth factor receptors mediate multiple physio-pathological responses to a diverse array of extracellular stimuli. In this regard, it has been largely demonstrated that GPCRs and growth factor receptors generate a multifaceted signaling network, which triggers relevant biological effects in normal and cancer cells. For instance, some GPCRs transactivate the epidermal growth factor receptor (EGFR), which stimulates diverse transduction pathways leading to gene expression changes, cell migration, survival and proliferation. Moreover, it has been reported that a functional interaction between growth factor receptors and steroid hormones like estrogens is involved in the growth of many types of tumors as well as in the resistance to endocrine therapy. This review highlights recent findings on the cross-talk between a member of the GPCR family, the G protein-coupled estrogen receptor 1 (GPER, formerly known as GPR30) and two main growth factor receptors like EGFR and insulin-like growth factor-I receptor (IGF-IR). The biological implications of the functional interaction between these important mediators of cell responses particularly in cancer are discussed. This article is part of a Special Issue entitled 'CSR 2013'. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Unveiling network-based functional features through integration of gene expression into protein networks.

    PubMed

    Jalili, Mahdi; Gebhardt, Tom; Wolkenhauer, Olaf; Salehzadeh-Yazdi, Ali

    2018-06-01

    Decoding health and disease phenotypes is one of the fundamental objectives in biomedicine. Whereas high-throughput omics approaches are available, it is evident that any single omics approach might not be adequate to capture the complexity of phenotypes. Therefore, integrated multi-omics approaches have been used to unravel genotype-phenotype relationships such as global regulatory mechanisms and complex metabolic networks in different eukaryotic organisms. Some of the progress and challenges associated with integrated omics studies have been reviewed previously in comprehensive studies. In this work, we highlight and review the progress, challenges and advantages associated with emerging approaches, integrating gene expression and protein-protein interaction networks to unravel network-based functional features. This includes identifying disease related genes, gene prioritization, clustering protein interactions, developing the modules, extract active subnetworks and static protein complexes or dynamic/temporal protein complexes. We also discuss how these approaches contribute to our understanding of the biology of complex traits and diseases. This article is part of a Special Issue entitled: Cardiac adaptations to obesity, diabetes and insulin resistance, edited by Professors Jan F.C. Glatz, Jason R.B. Dyck and Christine Des Rosiers. Copyright © 2018 Elsevier B.V. All rights reserved.

  2. Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics.

    PubMed

    Solan, Joell L; Lampe, Paul D

    2018-01-01

    Gap junctions are specialized membrane domains containing tens to thousands of intercellular channels. These channels permit exchange of small molecules (<1000Da) including ions, amino acids, nucleotides, metabolites and secondary messengers (e.g., calcium, glucose, cAMP, cGMP, IP 3 ) between cells. The common reductionist view of these structures is that they are composed entirely of integral membrane proteins encoded by the 21 member connexin human gene family. However, it is clear that the normal physiological function of this structure requires interaction and regulation by a variety of proteins, especially kinases. Phosphorylation is capable of directly modulating connexin channel function but the most dramatic effects on gap junction activity occur via the organization of the gap junction structures themselves. This is a direct result of the short half-life of the primary gap junction protein, connexin, which requires them to be constantly assembled, remodeled and turned over. The biological consequences of this remodeling are well illustrated during cardiac ischemia, a process wherein gap junctions are disassembled and remodeled resulting in arrhythmia and ultimately heart failure. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Synthetic Approach to biomolecular science by cyborg supramolecular chemistry.

    PubMed

    Kurihara, Kensuke; Matsuo, Muneyuki; Yamaguchi, Takumi; Sato, Sota

    2018-02-01

    To imitate the essence of living systems via synthetic chemistry approaches has been attempted. With the progress in supramolecular chemistry, it has become possible to synthesize molecules of a size and complexity close to those of biomacromolecules. Recently, the combination of precisely designed supramolecules with biomolecules has generated structural platforms for designing and creating unique molecular systems. Bridging between synthetic chemistry and biomolecular science is also developing methodologies for the creation of artificial cellular systems. This paper provides an overview of the recently expanding interdisciplinary research to fuse artificial molecules with biomolecules, that can deepen our understanding of the dynamical ordering of biomolecules. Using bottom-up approaches based on the precise chemical design, synthesis and hybridization of artificial molecules with biological materials have been realizing the construction of sophisticated platforms having the fundamental functions of living systems. The effective hybrid, molecular cyborg, approaches enable not only the establishment of dynamic systems mimicking nature and thus well-defined models for biophysical understanding, but also the creation of those with highly advanced, integrated functions. This article is part of a Special Issue entitled "Biophysical Exploration of Dynamical Ordering of Biomolecular Systems" edited by Dr. Koichi Kato. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Glia-neuron interactions in neurological diseases: Testing non-cell autonomy in a dish.

    PubMed

    Meyer, Kathrin; Kaspar, Brian K

    2017-02-01

    For the past century, research on neurological disorders has largely focused on the most prominently affected cell types - the neurons. However, with increasing knowledge of the diverse physiological functions of glial cells, their impact on these diseases has become more evident. Thus, many conditions appear to have more complex origins than initially thought. Since neurological pathologies are often sporadic with unknown etiology, animal models are difficult to create and might only reflect a small portion of patients in which a mutation in a gene has been identified. Therefore, reliable in vitro systems to studying these disorders are urgently needed. They might be a pre-requisite for improving our understanding of the disease mechanisms as well as for the development of potential new therapies. In this review, we will briefly summarize the function of different glial cell types in the healthy central nervous system (CNS) and outline their implication in the development or progression of neurological conditions. We will then describe different types of culture systems to model non-cell autonomous interactions in vitro and evaluate advantages and disadvantages. This article is part of a Special Issue entitled SI: Exploiting human neurons. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Targeting the nucleolus for cancer intervention.

    PubMed

    Quin, Jaclyn E; Devlin, Jennifer R; Cameron, Donald; Hannan, Kate M; Pearson, Richard B; Hannan, Ross D

    2014-06-01

    The contribution of the nucleolus to cancer is well established with respect to its traditional role in facilitating ribosome biogenesis and proliferative capacity. More contemporary studies however, infer that nucleoli contribute a much broader role in malignant transformation. Specifically, extra-ribosomal functions of the nucleolus position it as a central integrator of cellular proliferation and stress signaling, and are emerging as important mechanisms for modulating how oncogenes and tumor suppressors operate in normal and malignant cells. The dependence of certain tumor cells to co-opt nucleolar processes to maintain their cancer phenotypes has now clearly been demonstrated by the application of small molecule inhibitors of RNA Polymerase I to block ribosomal DNA transcription and disrupt nucleolar function (Bywater et al., 2012 [1]). These drugs, which selectively kill tumor cells in vivo while sparing normal cells, have now progressed to clinical trials. It is likely that we have only just begun to scratch the surface of the potential of the nucleolus as a new target for cancer therapy, with "suppression of nucleolar stress" representing an emerging "hallmark" of cancer. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Intra-plastid protein trafficking: how plant cells adapted prokaryotic mechanisms to the eukaryotic condition.

    PubMed

    Celedon, Jose M; Cline, Kenneth

    2013-02-01

    Protein trafficking and localization in plastids involve a complex interplay between ancient (prokaryotic) and novel (eukaryotic) translocases and targeting machineries. During evolution, ancient systems acquired new functions and novel translocation machineries were developed to facilitate the correct localization of nuclear encoded proteins targeted to the chloroplast. Because of its post-translational nature, targeting and integration of membrane proteins posed the biggest challenge to the organelle to avoid aggregation in the aqueous compartments. Soluble proteins faced a different kind of problem since some had to be transported across three membranes to reach their destination. Early studies suggested that chloroplasts addressed these issues by adapting ancient-prokaryotic machineries and integrating them with novel-eukaryotic systems, a process called 'conservative sorting'. In the last decade, detailed biochemical, genetic, and structural studies have unraveled the mechanisms of protein targeting and localization in chloroplasts, suggesting a highly integrated scheme where ancient and novel systems collaborate at different stages of the process. In this review we focus on the differences and similarities between chloroplast ancestral translocases and their prokaryotic relatives to highlight known modifications that adapted them to the eukaryotic situation. This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. 20 CFR 410.215 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or...; Duration of Entitlement; Filing of Claims and Evidence § 410.215 Duration of entitlement; parent, brother, or sister. (a) parent, brother, or sister is entitled to benefits beginning with the month all the...

  8. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent, brother, or sister. An individual is entitled to benefits if: (a) Such individual: (1) Is the parent, brother...

  9. 20 CFR 404.251 - Subsequent entitlement to benefits less than 12 months after entitlement to disability benefits...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Computing...) Disability before 1979; second entitlement after 1978. In this situation, we compute your second-entitlement... primary insurance amount computed for you as of the time of your second entitlement under any method for...

  10. SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors.

    PubMed

    Küspert, Melanie; Wegner, Michael

    2016-05-01

    Glial cells that express the chondroitin sulfate proteoglycan NG2 represent an inherently heterogeneous population. These so-called NG2-glia are present during development and in the adult CNS, where they are referred to as embryonic oligodendrocyte precursors and adult NG2-glia, respectively. They give rise to myelinating oligodendrocytes at all times of life. Over the years much has been learnt about the transcriptional network in embryonic oligodendrocyte precursors, and several transcription factors from the HLH, HMG-domain, zinc finger and homeodomain protein families have been identified as main constituents. Much less is known about the corresponding network in adult NG2-glia. Here we summarize and discuss current knowledge on functions of each of these transcription factor families in NG2-glia, and where possible compare transcriptional regulation in embryonic oligodendrocyte precursors and adult NG2-glia. This article is part of a Special Issue entitled SI:NG2-glia (Invited only). Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Fronto-striatal circuits in response-inhibition: Relevance to addiction

    PubMed Central

    Morein-Zamir, Sharon; Robbins, Trevor W.

    2015-01-01

    Disruptions to inhibitory control are believed to contribute to multiple aspects of drug abuse, from preexisting vulnerability in at-risk individuals, through escalation to dependence, to promotion of relapse in chronic users. Paradigms investigating the suppression of actions have been investigated in animal and human research on drug addiction. Rodent research has focused largely on impulsive behaviors, often gauged by premature responding, as a viable model highlighting the relevant role of dopamine and other neurotransmitters primarily in the striatum. Human research on action inhibition in stimulant dependence has highlighted impaired performance and largely prefrontal cortical abnormalities as part of a broader pattern of cognitive abnormalities. Animal and human research implicate inhibitory difficulties mediated by fronto-striatal circuitry both preceding and as a result of excessive stimulus use. In this regard, response-inhibition has proven a useful cognitive function to gauge the integrity of fronto-striatal systems and their role in contributing to impulsive and compulsive features of drug dependence. This article is part of a Special Issue entitled SI:Addiction circuits. PMID:25218611

  12. 'Omics' techniques for identifying flooding-response mechanisms in soybean.

    PubMed

    Komatsu, Setsuko; Shirasaka, Naoki; Sakata, Katsumi

    2013-11-20

    Plant growth and productivity are adversely influenced by various environmental stresses, which often lead to reduced seedling growth and decreased crop yields. Plants respond to stressful conditions through changes in 'omics' profiles, including transcriptomics, proteomics, and metabolomics. Linking plant phenotype to gene expression patterns, protein abundance, and metabolite accumulation is one of the main challenges for improving agricultural production. 'Omics' approaches may shed insight into the mechanisms that function in soybean in response to environmental stresses, particularly flooding by frequent rain, which occurs worldwide due to changes in global climate. Flooding causes significant reductions in the growth and yield of several crops, especially soybean. The application of 'omics' techniques may facilitate the development of flood-tolerant cultivars of soybean. In this review, the use of 'omics' techniques towards understanding the flooding-responsive mechanisms of soybeans is discussed, as the findings from these studies are expected to have applications in both breeding and agronomy. This article is part of a Special Issue entitled: Translational Plant Proteomics. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. Proteasomal and lysosomal protein degradation and heart disease.

    PubMed

    Wang, Xuejun; Robbins, Jeffrey

    2014-06-01

    In the cell, the proteasome and lysosomes represent the most important proteolytic machineries, responsible for the protein degradation in the ubiquitin-proteasome system (UPS) and autophagy, respectively. Both the UPS and autophagy are essential to protein quality and quantity control. Alterations in cardiac proteasomal and lysosomal degradation are remarkably associated with most heart disease in humans and are implicated in the pathogenesis of congestive heart failure. Studies carried out in animal models and in cell culture have begun to establish both sufficiency and, in some cases, the necessity of proteasomal functional insufficiency or lysosomal insufficiency as a major pathogenic factor in the heart. This review article highlights some recent advances in the research into proteasome and lysosome protein degradation in relation to cardiac pathology and examines the emerging evidence for enhancing degradative capacities of the proteasome and/or lysosome as a new therapeutic strategy for heart disease. This article is part of a Special Issue entitled "Protein Quality Control, the Ubiquitin Proteasome System, and Autophagy". Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Detection and manipulation of phosphoinositides.

    PubMed

    Idevall-Hagren, Olof; De Camilli, Pietro

    2015-06-01

    Phosphoinositides (PIs) are minor components of cell membranes, but play key roles in cell function. Recent refinements in techniques for their detection, together with imaging methods to study their distribution and changes, have greatly facilitated the study of these lipids. Such methods have been complemented by the parallel development of techniques for the acute manipulation of their levels, which in turn allow bypassing the long-term adaptive changes implicit in genetic perturbations. Collectively, these advancements have helped elucidate the role of PIs in physiology and the impact of the dysfunction of their metabolism in disease. Combining methods for detection and manipulation enables the identification of specific roles played by each of the PIs and may eventually lead to the complete deconstruction of the PI signaling network. Here, we review current techniques used for the study and manipulation of cellular PIs and also discuss advantages and disadvantages associated with the various methods. This article is part of a Special Issue entitled Phosphoinositides. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Detection and manipulation of phosphoinositides☆

    PubMed Central

    Idevall-Hagren, Olof; Camilli, Pietro De

    2016-01-01

    Phosphoinositides (PIs) are minor components of cell membranes, but play key roles in cell function. Recent refinements in techniques for their detection, together with imaging methods to study their distribution and changes, have greatly facilitated the study of these lipids. Such methods have been complemented by the parallel development of techniques for the acute manipulation of their levels, which in turn allow bypassing the long-term adaptive changes implicit in genetic perturbations. Collectively, these advancements have helped elucidate the role of PIs in physiology and the impact of the dysfunction of their metabolism in disease. Combining methods for detection and manipulation enables the identification of specific roles played by each of the PIs and may eventually lead to the complete deconstruction of the PI signaling network. Here, we review current techniques used for the study and manipulation of cellular PIs and also discuss advantages and disadvantages associated with the various methods. This article is part of a Special Issue entitled Phosphoinositides. PMID:25514766

  16. The Alternative complex III: properties and possible mechanisms for electron transfer and energy conservation.

    PubMed

    Refojo, Patrícia N; Teixeira, Miguel; Pereira, Manuela M

    2012-10-01

    Alternative complexes III (ACIII) are recently identified membrane-bound enzymes that replace functionally the cytochrome bc(1/)b(6)f complexes. In general, ACIII are composed of four transmembrane proteins and three peripheral subunits that contain iron-sulfur centers and C-type hemes. ACIII are built by a combination of modules present in different enzyme families, namely the complex iron-sulfur molybdenum containing enzymes. In this article a historical perspective on the investigation of ACIII is presented, followed by an overview of the present knowledge on these enzymes. Electron transfer pathways within the protein are discussed taking into account possible different locations (cytoplasmatic or periplasmatic) of the iron-sulfur containing protein and their contribution to energy conservation. In this way several hypotheses for energy conservation modes are raised including linear and bifurcating electron transfer pathways. This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012). Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Coexpression network analysis identifies transcriptional modules associated with genomic alterations in neuroblastoma.

    PubMed

    Yang, Liulin; Li, Yun; Wei, Zhi; Chang, Xiao

    2018-06-01

    Neuroblastoma is a highly complex and heterogeneous cancer in children. Acquired genomic alterations including MYCN amplification, 1p deletion and 11q deletion are important risk factors and biomarkers in neuroblastoma. Here, we performed a co-expression-based gene network analysis to study the intrinsic association between specific genomic changes and transcriptome organization. We identified multiple gene coexpression modules which are recurrent in two independent datasets and associated with functional pathways including nervous system development, cell cycle, immune system process and extracellular matrix/space. Our results also indicated that modules involved in nervous system development and cell cycle are highly associated with MYCN amplification and 1p deletion, while modules responding to immune system process are associated with MYCN amplification only. In summary, this integrated analysis provides novel insights into molecular heterogeneity and pathogenesis of neuroblastoma. This article is part of a Special Issue entitled: Accelerating Precision Medicine through Genetic and Genomic Big Data Analysis edited by Yudong Cai & Tao Huang. Copyright © 2017. Published by Elsevier B.V.

  18. Detection of protease activity in cells and animals.

    PubMed

    Verdoes, Martijn; Verhelst, Steven H L

    2016-01-01

    Proteases are involved in a wide variety of biologically and medically important events. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms. Protease activity can be detected by reporter substrates and activity-based probes, but not all of these reagents are suitable for intracellular or in vivo use. This review focuses on the detection of proteases in cells and in vivo. We summarize the use of probes and substrates as molecular tools, discuss strategies to deliver these tools inside cells, and describe sophisticated read-out techniques such as mass spectrometry and various imaging applications. This article is part of a Special Issue entitled: Physiological Enzymology and Protein Functions. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders.

    PubMed

    O'Farrell, Katherine; Harkin, Andrew

    2017-01-01

    The kynurenine pathway (KP), which is activated in times of stress and infection has been implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation of this tryptophan metabolising pathway results in the production of neuroactive metabolites which have the potential to interfere with normal neuronal functioning which may contribute to altered neuronal transmission and the emergence of symptoms of these brain disorders. This review investigates the involvement of the KP in a range of neurological disorders, examining recent in vitro, in vivo and clinical discoveries highlights evidence to indicate that the KP is a potential therapeutic target in both neurodegenerative and stress-related neuropsychiatric disorders. Furthermore, this review identifies gaps in our knowledge with regard to this field which are yet to be examined to lead to a more comprehensive understanding of the role of KP activation in brain health and disease. This article is part of the Special Issue entitled 'The Kynurenine Pathway in Health and Disease'. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Functionalized lipids and surfactants for specific applications.

    PubMed

    Kepczynski, Mariusz; Róg, Tomasz

    2016-10-01

    Synthetic lipids and surfactants that do not exist in biological systems have been used for the last few decades in both basic and applied science. The most notable applications for synthetic lipids and surfactants are drug delivery, gene transfection, as reporting molecules, and as support for structural lipid biology. In this review, we describe the potential of the synergistic combination of computational and experimental methodologies to study the behavior of synthetic lipids and surfactants embedded in lipid membranes and liposomes. We focused on select cases in which molecular dynamics simulations were used to complement experimental studies aiming to understand the structure and properties of new compounds at the atomistic level. We also describe cases in which molecular dynamics simulations were used to design new synthetic lipids and surfactants, as well as emerging fields for the application of these compounds. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Absorption and folding of melittin onto lipid bilayer membranes via unbiased atomic detail microsecond molecular dynamics simulation.

    PubMed

    Chen, Charles H; Wiedman, Gregory; Khan, Ayesha; Ulmschneider, Martin B

    2014-09-01

    Unbiased molecular simulation is a powerful tool to study the atomic details driving functional structural changes or folding pathways of highly fluid systems, which present great challenges experimentally. Here we apply unbiased long-timescale molecular dynamics simulation to study the ab initio folding and partitioning of melittin, a template amphiphilic membrane active peptide. The simulations reveal that the peptide binds strongly to the lipid bilayer in an unstructured configuration. Interfacial folding results in a localized bilayer deformation. Akin to purely hydrophobic transmembrane segments the surface bound native helical conformer is highly resistant against thermal denaturation. Circular dichroism spectroscopy experiments confirm the strong binding and thermostability of the peptide. The study highlights the utility of molecular dynamics simulations for studying transient mechanisms in fluid lipid bilayer systems. This article is part of a Special Issue entitled: Interfacially Active Peptides and Proteins. Guest Editors: William C. Wimley and Kalina Hristova. Copyright © 2014. Published by Elsevier B.V.

  2. A molecular ensemble in the rER for procollagen maturation.

    PubMed

    Ishikawa, Yoshihiro; Bächinger, Hans Peter

    2013-11-01

    Extracellular matrix (ECM) proteins create structural frameworks in tissues such as bone, skin, tendon and cartilage etc. These connective tissues play important roles in the development and homeostasis of organs. Collagen is the most abundant ECM protein and represents one third of all proteins in humans. The biosynthesis of ECM proteins occurs in the rough endoplasmic reticulum (rER). This review describes the current understanding of the biosynthesis and folding of procollagens, which are the precursor molecules of collagens, in the rER. Multiple folding enzymes and molecular chaperones are required for procollagen to establish specific posttranslational modifications, and facilitate folding and transport to the cell surface. Thus, this molecular ensemble in the rER contributes to ECM maturation and to the development and homeostasis of tissues. Mutations in this ensemble are likely candidates for connective tissue disorders. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. RISC assembly: Coordination between small RNAs and Argonaute proteins.

    PubMed

    Kobayashi, Hotaka; Tomari, Yukihide

    2016-01-01

    Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs, and PIWI-interacting RNAs, assemble with Argonaute (Ago) family proteins into the effector complex called RNA-induced silencing complex (RISC), which mediates sequence-specific target gene silencing. RISC assembly is not a simple binding between a small RNA and Ago; rather, it follows an ordered multi-step pathway that requires specific accessory factors. Some steps of RISC assembly and RISC-mediated gene silencing are dependent on or facilitated by particular intracellular platforms, suggesting their spatial regulation. In this review, we summarize the currently known mechanisms for RISC assembly of each small RNA class and propose a revised model for the role of the chaperone machinery in the duplex-initiated RISC assembly pathway. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. The interplay between inflammatory cytokines and the endocannabinoid system in the regulation of synaptic transmission.

    PubMed

    Rossi, Silvia; Motta, Caterina; Musella, Alessandra; Centonze, Diego

    2015-09-01

    Excessive glutamate-mediated synaptic transmission and secondary excitotoxicity have been proposed as key determinants of neurodegeneration in many neurological diseases. Soluble mediators of inflammation have recently gained attention owing to their ability to enhance glutamate transmission and affect synaptic sensitivity to neurotransmitters. In the complex crosstalk between soluble immunoactive molecules and synapses, the endocannabinoid system (ECS) plays a central role, exerting an indirect neuroprotective action by inhibiting cytokine-dependent synaptic alterations, and a direct neuroprotective effect by limiting glutamate transmission and excitotoxic damage. On the other hand, the endocannabinoid (eCB)-mediated control of synaptic transmission is altered by proinflammatory cytokines with consequent effects in central nervous system (CNS) disorders. In this review, we summarize the interactions, at the pre- and postsynaptic level, between major inflammatory cytokines and the ECS. In addition, the behavioral and clinical consequences of the modulation of synaptic transmission during neuroinflammation are discussed. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Enzymatic cybernetics: an unpublished work by Jacques Monod.

    PubMed

    Gayon, Jean

    2015-06-01

    In 1959, Jacques Monod wrote a manuscript entitled Cybernétique enzymatique [Enzymatic cybernetics]. Never published, this unpublished manuscript presents a synthesis of how Monod interpreted enzymatic adaptation just before the publication of the famous papers of the 1960s on the operon. In addition, Monod offers an example of a philosophy of biology immersed in scientific investigation. Monod's philosophical thoughts are classified into two categories, methodological and ontological. On the methodological side, Monod explicitly hints at his preferences regarding the scientific method in general: hypothetical-deductive method, and use of theoretical models. He also makes heuristic proposals regarding molecular biology: the need to analyse the phenomena in question at the level of individual cells, and the dual aspect of all biological explanation, functional and evolutionary. Ontological issues deal with the notions of information and genetic determinism, "cellular memory", the irrelevance of the notion of "living matter", and the usefulness of a cybernetic comprehension of molecular biology. Copyright © 2015 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  6. Measuring specificity in multi-substrate/product systems as a tool to investigate selectivity in vivo.

    PubMed

    Kuo, Yin-Ming; Henry, Ryan A; Andrews, Andrew J

    2016-01-01

    Multiple substrate enzymes present a particular challenge when it comes to understanding their activity in a complex system. Although a single target may be easy to model, it does not always present an accurate representation of what that enzyme will do in the presence of multiple substrates simultaneously. Therefore, there is a need to find better ways to both study these enzymes in complicated systems, as well as accurately describe the interactions through kinetic parameters. This review looks at different methods for studying multiple substrate enzymes, as well as explores options on how to most accurately describe an enzyme's activity within these multi-substrate systems. Identifying and defining this enzymatic activity should help clear the way to using in vitro systems to accurately predicting the behavior of multi-substrate enzymes in vivo. This article is part of a Special Issue entitled: Physiological Enzymology and Protein Functions. Copyright © 2015. Published by Elsevier B.V.

  7. Introduction: Framing 'Post-AIDS' and Global Health Discourses in 2015 and Beyond.

    PubMed

    O'Connell, Gráinne

    2017-05-19

    This special issue, entitled "Post-AIDS' and Global Health Discourses: Interdisciplinary Perspectives,' emerged from a one day Medical Humanities symposium at the Leeds Centre for Medical Humanities, at the University of Leeds, England, on February 27th 2015. This special issue focusses on the perceived deprioritising of HIV and AIDS in the Sustainable Development Goals, or SDGs, that were launched in 2015. The SDGs function as policy benchmarks for all entities within the United Nations system and they supersede the Millennium Development Goals, or MDGs, which expired in 2015. As the word millennium indicates, the MDGs were launched in 2000 and 2015 was designated as the benchmark year when the successes and shortcomings of the MDGs would be critically assessed. One key difference between the MDGs and the SDGs, which D'Ambruoso foregrounds (2013), is that the writing process underpinning the SDGs involved lengthy consultations, and feedback, with communities and health care practitioners around the world. By contrast, because the MDGs were mainly written by government officials, policy makers and health care practitioners without consulting wider communities, the processes underpinning the SDGs consultations are more inclusive than the MDGs. What is most critical about the SDGs for this special issue, however, is that they reflect a clear shift away from 'HIV exceptionalism' and towards what critics have described as 'post-AIDS' rhetoric, specifically when one compares the MDG health goal 6 and the SDG health goal 3.

  8. An introduction to the special issue on Geoscience Papers of the Future

    NASA Astrophysics Data System (ADS)

    David, Cédric H.; Gil, Yolanda; Duffy, Christopher J.; Peckham, Scott D.; Venayagamoorthy, S. Karan

    2016-10-01

    Advocates of enhanced quality for published scientific results are increasingly voicing the need for further transparency of data and software for scientific reproducibility. However, such advanced digital scholarship can appear perplexing to geoscientists that are seduced by the concept of open science yet wonder about the exact mechanics and implications of the associated efforts. This special issue of Earth and Space Science entitled "Geoscience Papers of the Future" includes a review of existing best practices for digital scholarship and bundles a set of example articles that share their digital research products and reflect on the process of opening their scientific approach in a common quest for reproducible science.

  9. Reforms in pedagogy and the Confucian tradition: looking below the surface

    NASA Astrophysics Data System (ADS)

    Ho, Felix M.

    2018-03-01

    This Forum article addresses some of the issues raised in the article by Ying-Syuan Huang and Anila Asghar's paper entitled: Science education reform in Confucian learning cultures: teachers' perspectives on policy and practice in Taiwan. An attempt is made to highlight the need for a more nuanced approach in considering the Confucian education tradition and its compatibility with education reforms. In particular, the article discusses issues concerning the historical development of the Confucian education tradition, challenges in reform implementation that are in reality tradition-independent, as well as opportunities and points of convergence that the Confucian education tradition presents that can in fact be favorable to implementation of reform-based pedagogies.

  10. Human Rights and Dignity Behind Bars.

    PubMed

    Maschi, Tina; Richter, Marina

    2017-01-01

    Death and dying in prisons constitute a topic of growing importance across the globe. Based on the contributions made in this special issue, we reflect on current debates and outline recommendations for dialogue and practice. Scientific dialogue across the Atlantic, and across the globe, provides insights into different national carceral systems and their ways of dealing with end of life behind bars. At the same time, the comparison also helps to identify basic needs and practices that can work in various settings. We identify several issues where further efforts need to be taken to deepen the dialogue. A common ground for all advancement of legislation and practice constitute the minimal level of rights to which every human being is entitled.

  11. 42 CFR 406.12 - Individual under age 65 who is entitled to social security or railroad retirement disability...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Individual under age 65 who is entitled to social... is entitled to social security or railroad retirement disability benefits. (a) Basic requirements. An...) Entitled or deemed entitled to social security disability benefits as an insured individual, child, widow...

  12. "I Bought My Degree, Now I Want My Job!" Is Academic Entitlement Related to Prospective Workplace Entitlement?

    ERIC Educational Resources Information Center

    Peirone, Amy; Maticka-Tyndale, Eleanor

    2017-01-01

    Academic entitlement, a term that defines students' expectations of academic success independent of performance, has been linked with a number of maladaptive behaviors. This study examined the potential relationship between academic entitlement and prospective workplace entitlement in a sample of Canadian students (N=1024) using an online survey.…

  13. 42 CFR 406.12 - Individual under age 65 who is entitled to social security or railroad retirement disability...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Individual under age 65 who is entitled to social... is entitled to social security or railroad retirement disability benefits. (a) Basic requirements. An...) Entitled or deemed entitled to social security disability benefits as an insured individual, child, widow...

  14. 42 CFR 406.12 - Individual under age 65 who is entitled to social security or railroad retirement disability...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Individual under age 65 who is entitled to social... is entitled to social security or railroad retirement disability benefits. (a) Basic requirements. An...) Entitled or deemed entitled to social security disability benefits as an insured individual, child, widow...

  15. 42 CFR 406.12 - Individual under age 65 who is entitled to social security or railroad retirement disability...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Individual under age 65 who is entitled to social... is entitled to social security or railroad retirement disability benefits. (a) Basic requirements. An...) Entitled or deemed entitled to social security disability benefits as an insured individual, child, widow...

  16. Famine as agricultural catastrophe: the crisis of 1622-4 in east Lancashire.

    PubMed

    Hoyle, R W

    2010-01-01

    This article argues that historians have paid insufficient attention to the agrarian roots of early modern English famines. While not dismissing the insights arising from entitlements theory, the article takes issue with recent writings that have explained the famine of 1622–3 in north-west England as an entitlements crisis. It offers new empirical evidence from an estate in east Lancashire to demonstrate the scale of the crisis in the early 1620s, using estate accounts to produce new price data and estimates of productivity. On the basis of oat tithe data, the scale of the shortfall in foodstuffs in the harvest of 1621 is demonstrated as being probably in the region of a third; that of the following year has to be inferred from price data. The evidence shows that the crisis was not limited to the arable economy, but was followed by an extensive restocking of the pastoral economy. The article therefore makes a contribution to the growing interest in weather as an exogenous factor.

  17. Proceedings of second geopressured geothermal energy conference, Austin, Texas, February 23--25, 1976. Volume V. Legal, institutional, and environmental

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vanston, J.H.; Elmer, D.B.; Gustavson, T.C.

    Three separate abstracts were prepared for Volume V of the Proceedings of the Conference. Sections are entitled: Legal Issues in the Development of Geopressured--Geothermal Resources of Texas and Louisiana Gulf Coast; The Development of Geothermal Energy in the Gulf Coast; Socio-economic, Demographic, and Political Considerations; and Geothermal Resources of the Texas Gulf Coast--Environmental Concerns arising from the Production and Disposal of Geothermal waters. (MCW)

  18. Chemical Reactions in Turbulent Mixing Flows

    DTIC Science & Technology

    1991-09-14

    explored Reynolds number effects on turbulent flame length and the influence of buoyancy on turbulent jet flames; 2. completion of a thesis entitled...the dependence of flame length on Reynolds number was begun, and the issue of buoyancy was investigated. L._Lw~ Pt-lO%Rh 2 ൡ g rn wire Flame L ZoneY...105. The flame length at a given Reynolds number was determined from the time-averaged, line- integrated temperature measurements performed by the cold

  19. U.S. Army War College Guide to National Security Issues. Volume 2. National Security Policy and Strategy

    DTIC Science & Technology

    2012-06-01

    1998 National War College paper entitled “U.S. National Se- curity Structure: A New Model for the 21st Century” defines the national security community ...fueled by revolu- tions in communications and information management, the emergence of a truly global market and world economy, the primacy of economic...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions , searching existing data sources

  20. U.S.-Mexico Economic Relations: Trends, Issues, and Implications

    DTIC Science & Technology

    2009-04-03

    and high fructose corn syrup . Mexico argued that the sugar side letter negotiated under NAFTA entitled it to ship net sugar surplus to the United...that imports of high fructose corn syrup (HFCS) sweeteners from the United States constituted dumping, and it imposed anti-dumping duties for some time...industries to restrict HFCS imports from the United States. In late 2001, the Mexican Congress imposed a 20% tax on soft drinks made with corn syrup

  1. Joint Force Quarterly. Issue 63, 4th Quarter 2011

    DTIC Science & Technology

    2011-10-01

    wondrous trinity” for use in the current threat environment, Mr. Owens could refer to my piece entitled “The Age of Irregular Warfare: So What...listen, but its future enemy did. When it comes to good ideas, neither rank nor age confers a monopoly. JFQ is intended to stay at the vanguard, to...will need to evolve with an emphasis on rejuvenating and sustaining the country’s economic vitality while relying increasingly on credible forms of

  2. Science textbooks for lower secondary schools in Brunei: issues of gender equity

    NASA Astrophysics Data System (ADS)

    Elgar, Ann G.

    2004-07-01

    This paper is concerned with issues affecting equity in science education for girls and boys. In the paper the results of an investigation into the recently published (1998-2000) series of textbooks entitled Lower Secondary Science for Brunei Darussalam are presented. In the first part of the paper, background issues of continuing gender inequality in science education and of the nature and scope of textbook analyses are outlined. Then the representation of males and females in both illustrations and text in the Bruneian textbooks is discussed. From this analysis a picture emerges of the extent to which science is portrayed as a pursuit of equal appropriateness for both boys and girls. The paper concludes with a consideration of the implications of the findings presented within the wider context of gender and education in Brunei.

  3. International Conference on Harmonisation; guidance on the M4 Common Technical Document--Quality: Questions and Answers/Location Issues; availability. Notice.

    PubMed

    2004-06-09

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "M4: The CTD--Quality: Questions and Answers/Location Issues." The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). This guidance provides further clarification for preparing the quality components of an application file in the common technical document (CTD) format. The guidance addresses the relationship between linked sections for certain parameters (such as polymorphism and particle size), and it addresses location issues (by indicating the section in which to place requested information). The guidance is intended to ease the preparation of paper and electronic submissions, facilitate regulatory reviews, and simplify the exchange of regulatory information among regulatory authorities.

  4. René Leriche and “Philosophy of Surgery” in the light of contemporary medical ethics

    PubMed Central

    Akça, Tamer; Aydın, Süha

    2013-01-01

    Prof. Dr. René Leriche was a famous French surgeon who lived between 1879 and 1955. After working as a vascular surgeon in Lyon, he was appointed professor at the University of Strasbourg in 1924 and later the Paris Collége de France in 1937. Leriche had proposed vascular patches as the ideal treatment for obliterated vascular segments and advocated the necessity of sympathectomy in arterial diseases in the 1920s. He defined “Leriche Syndrome” in 1923 which is known by his name and which develops as a result of incomplete obstruction of the aortic bifurcation. René Leriche wrote a monograph entitled “La Chirurgie de la Douleur-Pain Surgery” in 1940 and he also became a pioneer in the sympathectomy procedure for pain treatment. René Leriche focused on topics that must be remembered again today, including surgery advanced into science, the physiological basis of surgery, research methods, as well as issues such as business technology, humanity in surgery, surgical essence and surgeon’s qualifications in the book entitled “La Philosophie de la Chirurgie-Philosophy of Surgery” that he wrote in 1951. In this review, the issues that Prof. Dr. René Leriche addressed in middle of the 20th century were revised in the light of contemporary medical ethics. PMID:25931863

  5. Teaching the Interrelationship between Stress, Emotions, and Cardiovascular Risk Using a Classic Paper by Walter Cannon

    ERIC Educational Resources Information Center

    Gwirtz, Patricia A.

    2008-01-01

    Classroom discussion of the classic article by Walter B. Cannon in 1914, entitled "The emergency function of the adrenal medulla in pain and the major emotions," is an excellent tool to teach graduate students the interaction between stress, emotions, and cardiovascular function. Using this article, we are able to review important early research…

  6. Changing Perspectives for Practice in Stuttering: Echoes from a Celtic Past, when Wordlessness Was Entitled to Time

    ERIC Educational Resources Information Center

    Leahy, Margaret M.

    2005-01-01

    Changing perspectives for practice in stuttering therapy are informed by the changes in knowledge, social values, and belief systems of a society. The International Classification of Functioning, Disability and Health (ICF; World Health Organization, 2001) has a sociological emphasis with a focus on the ability and functioning of the person, and…

  7. Some Specifications for an Undergraduate Course in Digital Subsystems. An Interim Report of the Cosine Committee.

    ERIC Educational Resources Information Center

    Commission on Engineering Education, Washington, DC.

    This report describes an undergraduate course in digital subsystems. The course is divided into two major parts. Part I is entitled Electronic Circuits and Functional Units. The material in this part of the course proceeds from simple understandings of circuits to the progressively more complex functional units. Early emphasis is placed on basic…

  8. Innovation and Integrity in Intervention Research: Conceptual Issues, Methodology, and Knowledge Translation.

    PubMed

    Malti, Tina; Beelmann, Andreas; Noam, Gil G; Sommer, Simon

    2018-04-01

    In this article, we introduce the special issue entitled Innovation and Integrity in Intervention Science. Its focus is on essential problems and prospects for intervention research examining two related topics, i.e., methodological issues and research integrity, and challenges in the transfer of research knowledge into practice and policy. The main aims are to identify how to advance methodology in order to improve research quality, examine scientific integrity in the field of intervention science, and discuss future steps to enhance the transfer of knowledge about evidence-based intervention principles into sustained practice, routine activities, and policy decisions. Themes of the special issue are twofold. The first includes questions about research methodology in intervention science, both in terms of research design and methods, as well as data analyses and the reporting of findings. Second, the issue tackles questions surrounding the types of knowledge translation frameworks that might be beneficial to mobilize the transfer of research-based knowledge into practice and public policies. The issue argues that innovations in methodology and thoughtful approaches to knowledge translation can enable transparency, quality, and sustainability of intervention research.

  9. Capabilities and Incapabilities of the Capabilities Approach to Health Justice.

    PubMed

    Selgelid, Michael J

    2016-01-01

    This first part of this article critiques Sridhar Venkatapuram's conception of health as a capability. It argues that Venkatapuram relies on the problematic concept of dignity, implies that those who are unhealthy lack lives worthy of dignity (which seems politically incorrect), sets a low bar for health, appeals to metaphysically problematic thresholds, fails to draw clear connections between appealed-to capabilities and health, and downplays the importance/relevance of health functioning. It concludes by questioning whether justice entitlements should pertain to the capability for health versus health achievements, challenging Venkatapuram's claims about the strength of health entitlements, and demonstrating that the capabilities approach is unnecessary to address social determinants of health. © 2016 John Wiley & Sons Ltd.

  10. Health care information infrastructure: what will it be and how will we get there?

    NASA Astrophysics Data System (ADS)

    Kun, Luis G.

    1996-02-01

    During the first Health Care Technology Policy [HCTPI conference last year, during Health Care Reform, four major issues were brought up in regards to the underway efforts to develop a Computer Based Patient Record (CBPR)I the National Information Infrastructure (NIl) as part of the High Performance Computers & Communications (HPCC), and the so-called "Patient Card" . More specifically it was explained how a national information system will greatly affect the way health care delivery is provided to the United States public and reduce its costs. These four issues were: Constructing a National Information Infrastructure (NIl); Building a Computer Based Patient Record System; Bringing the collective resources of our National Laboratories to bear in developing and implementing the NIl and CBPR, as well as a security system with which to safeguard the privacy rights of patients and the physician-patient privilege; Utilizing Government (e.g. DOD, DOE) capabilities (technology and human resources) to maximize resource utilization, create new jobs and accelerate technology transfer to address health care issues. During the second HCTP conference, in mid 1 995, a section of this meeting entitled: "Health Care Technology Assets of the Federal Government" addressed benefits of the technology transfer which should occur for maximizing already developed resources. Also a section entitled:"Transfer and Utilization of Government Technology Assets to the Private Sector", looked at both Health Care and non-Health Care related technologies since many areas such as Information Technologies (i.e. imaging, communications, archival I retrieval, systems integration, information display, multimedia, heterogeneous data bases, etc.) already exist and are part of our National Labs and/or other federal agencies, i.e. ARPA. These technologies although they are not labeled under "Health Care" programs they could provide enormous value to address technical needs. An additional issue deals with both the technical (hardware, software) and human expertise that resides within these labs and their possible role in creating cost effective solutions.

  11. Transfer and utilization of government technology assets to the private sector in the fields of health care and information technologies

    NASA Astrophysics Data System (ADS)

    Kun, Luis G.

    1995-10-01

    During the first Health Care Technology Policy conference last year, during health care reform, four major issues were brought up in regards to the efforts underway to develop a computer based patient record (CBPR), the National Information Infrastructure (NII) as part of the high performance computers and communications (HPCC), and the so-called 'patient card.' More specifically it was explained how a national information system will greatly affect the way health care delivery is provided to the United States public and reduce its costs. These four issues were: (1) Constructing a national information infrastructure (NII); (2) Building a computer based patient record system; (3) Bringing the collective resources of our national laboratories to bear in developing and implementing the NII and CBPR, as well as a security system with which to safeguard the privacy rights of patients and the physician-patient privilege; (4) Utilizing government (e.g., DOD, DOE) capabilities (technology and human resources) to maximize resource utilization, create new jobs, and accelerate technology transfer to address health care issues. This year a section of this conference entitled: 'Health Care Technology Assets of the Federal Government' addresses benefits of the technology transfer which should occur for maximizing already developed resources. This section entitled: 'Transfer and Utilization of Government Technology Assets to the Private Sector,' will look at both health care and non-health care related technologies since many areas such as information technologies (i.e. imaging, communications, archival/retrieval, systems integration, information display, multimedia, heterogeneous data bases, etc.) already exist and are part of our national labs and/or other federal agencies, i.e., ARPA. These technologies although they are not labeled under health care programs they could provide enormous value to address technical needs. An additional issue deals with both the technical (hardware, software) and human expertise that resides within these labs and their possible role in creating cost effective solutions.

  12. 7 CFR 3800.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) WORLD AGRICULTURAL OUTLOOK BOARD, DEPARTMENT OF AGRICULTURE ORGANIZATION AND FUNCTIONS § 3800.1 General. The World Agricultural Outlook Board (WAOB) was established on June 3, 1977, by Secretary's Memorandum 1920, entitled “World Food and Agricultural Outlook and...

  13. 42 CFR 421.401 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... perform a particular Medicare administrative function in relation to: (1) A particular individual entitled... 42 Public Health 3 2010-10-01 2010-10-01 false Definitions. 421.401 Section 421.401 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE...

  14. A Business Case Analysis of the Direct Health Care Provider Program Womack Army Medical Center, Fort Bragg, N.C.

    DTIC Science & Technology

    2001-05-01

    Unspecified (959.01) Hypovolemia (276.5) Medicine Headache, Migraine Variant (346.20) Infectious Mononucleosis (075) Alcohol Abuse, Unspecified (305.00...under the FTCA. In an article entitled “Can the Feres Doctrine Survive TRICARE, and Should It?”, the author examines issues that complicate the...Enteritis – Infectious (009.1) Irritable Bowel Syndrome (564.1) Epilepsy NOS (345.90) Herpes Simplex, NOS (054.9) Ulcerative Colitis (556.9) Head Injury

  15. Vaccines for Children: Critical Issues in Design and Implementation. Report to Congressional Requesters [and] Vaccines for Children: Major Implementation Hurdles Remain. Testimony of Kwai-Cheung Chan, before the Subcommittee on Labor, Health, Human Services, and Education, Committee on Appropriations, United States Senate.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Program Evaluation and Methodology Div.

    In response to congressional request, this report provides information on the implementation plans developed by the Center for Disease Control (CDC) for the Vaccines for Children (VFC) Program. Introductory material indicates that the VFC was created to increase vaccine coverage levels nationwide by creating an entitlement to free vaccine for…

  16. Publications on acoustics research at the Langley Research Center during 1980-1986

    NASA Technical Reports Server (NTRS)

    Sutherland, Linda W. (Compiler)

    1988-01-01

    This report is a compilation of publications from acoustics research at the Langley Research Center. The reports are listed in chronological order and summarize the written output of the Acoustics Division and its predecessor, The Acoustics and Noise Reduction Division, for the period 1980 through 1986. The information assembled has been extracted from the 1980 through 1986 issues for the Technical Memorandum entitled, Scientific and Technical Information Output of the Langley Research Center for the Calendar Year.

  17. The association between LEPR Q223R polymorphisms and breast cancer risk.

    PubMed

    Wang, Yadong; Yang, Haiyan; Gao, Huiyan; Wang, Haiyu

    2015-05-01

    Recently, we have read with great interest the article entitled "The association between polymorphisms in the leptin receptor (LEPR) gene and risk of breast cancer: a systematic review and pooled analysis" published online by Wang et al. (Breast Cancer Res Treat 136:231-239, 2012). This article suggests that the A allele of LEPR gene rs1137101 variant was low-penetrant risk factor for developing breast cancer. The result is encouraging. Nevertheless, several key issues are worth noticing.

  18. An Alternative Approach to ``Measuring Horsepower and Torque Curves of a Car''

    NASA Astrophysics Data System (ADS)

    Graney, Chris M.

    2005-09-01

    The article in the September 2003 issue of TPT by John Ross Buschert of Goshen College entitled "Measuring Horsepower and Torque Curves of a Car" was excellent. I attained similar results using existing automobile test data. Automobile performance tests done by magazines such as Road & Track are a treasure trove of good-quality physics data. Performance tests often contain all the data needed to replicate Professor Buschert's analysis of the power and torque output of automobile engines.

  19. 78 FR 79479 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ...Notice is hereby given that the U.S. International Trade Commission has received a complaint entitled Certain Standard Cell Libraries, Products Containing or Made Using the Same, Integrated Circuits Made Using the Same, and Products Containing Such Integrated Circuits, DN 2994; the Commission is soliciting comments on any public interest issues raised by the complaint or complainant's filing under section 210.8(b) of the Commission's Rules of Practice and Procedure (19 CFR 210.8(b)).

  20. A Study of Transparent Plastics for use on Aircraft. Supplement

    NASA Technical Reports Server (NTRS)

    Axilrod, Benjamin M.; Kline, Gordon M.

    1937-01-01

    This supplement to a NACA study issued in May 1937 entitled "A Study of Transparent Plastics for Use on Aircraft", contains two tables. These tables contain data on bursting strengths of plastics, particularly at low temperatures. Table 1 contains the values reported in a table of the original memorandum, and additional values obtained at approximately 25 C, for three samples of Acrylate resin. The second table contains data obtained for the bursting strength when one surface of the plastic was cooled to approximately -35 C.

  1. Responsible authorship in engineering fields: an overview of current ethical challenges.

    PubMed

    Borenstein, Jason

    2011-06-01

    The primary aim of this article is to identify ethical challenges relating to authorship in engineering fields. Professional organizations and journals do provide crucial guidance in this realm, but this cannot replace the need for frequent and diligent discussions in engineering research communities about what constitutes appropriate authorship practice. Engineering researchers should seek to identify and address issues such as who is entitled to be an author and whether publishing their research could potentially harm the public.

  2. Navy Nuclear Aircraft Carrier (CVN) Homeporting at Mayport: Background and Issues for Congress

    DTIC Science & Technology

    2010-04-23

    Release No. 233-09 of April 10, 2009, entitled “Quadrennial Defense Review To Determine Aircraft Carrier Homeporting In Mayport,” available online at...The figure of about 32 nautical miles is the straight-line distance between the two locations, as calculated by the “How Fair Is It?” online ...distance between the two locations, as calculated by the “How Fair Is It?” online distance calculator available at http://www.indo.com/cgi-bin/dist

  3. Navy Nuclear Aircraft Carrier (CVN) Homeporting at Mayport: Background and Issues for Congress

    DTIC Science & Technology

    2010-12-09

    Release No. 233-09 of April 10, 2009, entitled “Quadrennial Defense Review To Determine Aircraft Carrier Homeporting In Mayport,” available online at...is the straight-line distance between the two locations, as calculated by the “How Fair Is It?” online distance calculator available at http...straight-line distance between the two locations, as calculated by the “How Fair Is It?” online distance calculator available at http://www.indo.com/cgi

  4. Joint Conference on Marine Safety and Environment/Ship Production (1st), held 1-5 June 1992

    DTIC Science & Technology

    1992-06-05

    have to face fresh challenges in the future. But as long as we regard these challenges as opportunities, we will remain masters of our own destiny ...has recently published for discussion an “ Embryo Code of Practice” (1991) entitled “Engineers and Risk Issues”. Thii draft Code is intended to...Department of Energy5 Her Majesty’s Stationery Office. Cm.1310. The Engineering Counci1 (1991) Engineers and Risk Issues : An Embryo Code of Practice. London

  5. Part II--IEPS Reports. The proper function of teaching hospitals within health systems.

    PubMed

    1998-01-01

    The main points of the discussions from the international seminar organised by the World Health Organisation and the Institute for the Study of Health Policies (IEPS) were published in French by Flammarion Medecine-Sciences in the Collection entitled "The IEPS Reports" and in English by the WHO under the title "The Proper Function of Teaching Hospitals within Health Systems" (1995).

  6. Arctic Freshwater Synthesis: Summary of key emerging issues

    NASA Astrophysics Data System (ADS)

    Prowse, T.; Bring, A.; Mârd, J.; Carmack, E.; Holland, M.; Instanes, A.; Vihma, T.; Wrona, F. J.

    2015-10-01

    In response to a joint request from the World Climate Research Program's Climate and Cryosphere Project, the International Arctic Science Committee, and the Arctic Council's Arctic Monitoring and Assessment Program an updated scientific assessment has been conducted of the Arctic Freshwater System (AFS), entitled the Arctic Freshwater Synthesis (AFSΣ). The major reason behind the joint request was an increasing concern that changes to the AFS have produced, and could produce even greater, changes to biogeophysical and socioeconomic systems of special importance to northern residents and also produce extra-Arctic climatic effects that will have global consequences. The AFSΣ was structured around six key thematic areas: atmosphere, oceans, terrestrial hydrology, terrestrial ecology, resources, and modeling, the review of each coauthored by an international group of scientists and published as separate manuscripts in this special issue of Journal of Geophysical Research-Biogeosciences. This AFSΣ summary manuscript reviews key issues that emerged during the conduct of the synthesis, especially those that are cross-thematic in nature, and identifies future research required to address such issues.

  7. Zebrafish models for the functional genomics of neurogenetic disorders.

    PubMed

    Kabashi, Edor; Brustein, Edna; Champagne, Nathalie; Drapeau, Pierre

    2011-03-01

    In this review, we consider recent work using zebrafish to validate and study the functional consequences of mutations of human genes implicated in a broad range of degenerative and developmental disorders of the brain and spinal cord. Also we present technical considerations for those wishing to study their own genes of interest by taking advantage of this easily manipulated and clinically relevant model organism. Zebrafish permit mutational analyses of genetic function (gain or loss of function) and the rapid validation of human variants as pathological mutations. In particular, neural degeneration can be characterized at genetic, cellular, functional, and behavioral levels. Zebrafish have been used to knock down or express mutations in zebrafish homologs of human genes and to directly express human genes bearing mutations related to neurodegenerative disorders such as spinal muscular atrophy, ataxia, hereditary spastic paraplegia, amyotrophic lateral sclerosis (ALS), epilepsy, Huntington's disease, Parkinson's disease, fronto-temporal dementia, and Alzheimer's disease. More recently, we have been using zebrafish to validate mutations of synaptic genes discovered by large-scale genomic approaches in developmental disorders such as autism, schizophrenia, and non-syndromic mental retardation. Advances in zebrafish genetics such as multigenic analyses and chemical genetics now offer a unique potential for disease research. Thus, zebrafish hold much promise for advancing the functional genomics of human diseases, the understanding of the genetics and cell biology of degenerative and developmental disorders, and the discovery of therapeutics. This article is part of a Special Issue entitled Zebrafish Models of Neurological Diseases. Copyright © 2010 Elsevier B.V. All rights reserved.

  8. 43 CFR 418.35 - Efficiencies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of entitlement water actually delivered at the headgates. Since most of the distribution system losses such as evaporation and seepage do not change significantly with the amount of water delivered (i.e., these losses are principally a function of water surface area and the wetted perimeter of the...

  9. 43 CFR 418.35 - Efficiencies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of entitlement water actually delivered at the headgates. Since most of the distribution system losses such as evaporation and seepage do not change significantly with the amount of water delivered (i.e., these losses are principally a function of water surface area and the wetted perimeter of the...

  10. 43 CFR 418.35 - Efficiencies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of entitlement water actually delivered at the headgates. Since most of the distribution system losses such as evaporation and seepage do not change significantly with the amount of water delivered (i.e., these losses are principally a function of water surface area and the wetted perimeter of the...

  11. 43 CFR 418.35 - Efficiencies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of entitlement water actually delivered at the headgates. Since most of the distribution system losses such as evaporation and seepage do not change significantly with the amount of water delivered (i.e., these losses are principally a function of water surface area and the wetted perimeter of the...

  12. 43 CFR 418.35 - Efficiencies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of entitlement water actually delivered at the headgates. Since most of the distribution system losses such as evaporation and seepage do not change significantly with the amount of water delivered (i.e., these losses are principally a function of water surface area and the wetted perimeter of the...

  13. 77 FR 38765 - Notice of Intent To Revise a Currently Approved Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ..., filing of petitions and applications and agency #0;statements of organization and functions are examples... information collection entitled, ``Cooperative State Research, Education, and Extension Service Grant... INFORMATION CONTACT: Gidel Mendez; Email: [email protected] . SUPPLEMENTARY INFORMATION: Title: NIFA Grant...

  14. 76 FR 52133 - Defense Federal Acquisition Regulation Supplement; Contractors Performing Private Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... 0750-AH28 Defense Federal Acquisition Regulation Supplement; Contractors Performing Private Security..., entitled ``Contractors Performing Private Security Functions in Areas of Combat Operations or Other... of DoD and other Governmental private security contractors. A clause to cover the interagency...

  15. 10 CFR 51.61 - Environmental report-independent spent fuel storage installation (ISFSI) or monitored retrievable...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2... Control Desk, Director, Office of Nuclear Material Safety and Safeguards, a separate document entitled...

  16. A Progressively Realizable Right to Health and Global Governance.

    PubMed

    Daniels, Norman

    2015-12-01

    A moral right to health or health care is a special instance of a right to fair equality of opportunity. Nation-states generally have the capabilities to specify the entitlements of such a right and to raise the resources needed to satisfy those entitlements. Can these functions be replicated globally, as a global right to health or health care requires? The suggestion that "better global governance" is needed if such a global right is to be claimed requires that these two central capabilities be present. It is unlikely that nation-states would concede these two functions to a form of global governance, for doing so would seriously compromise the authority that is generally included in sovereignty. This claim is a specification of what is often recognized as the "sovereignty problem." The argument of this paper is not an "impossibility" claim, but a best guess about whether the necessary conditions for better global governance that supports a global right to health or health care can be achieved.

  17. Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex.

    PubMed

    Longenecker, R J; Galazyuk, A V

    2012-11-16

    Recently prepulse inhibition of the acoustic startle reflex (ASR) became a popular technique for tinnitus assessment in laboratory animals. This method confers a significant advantage over the previously used time-consuming behavioral approaches utilizing basic mechanisms of conditioning. Although this technique has been successfully used to assess tinnitus in different laboratory animals, many of the finer details of this methodology have not been described enough to be replicated, but are critical for tinnitus assessment. Here we provide detail description of key procedures and methodological issues that provide guidance for newcomers with the process of learning to correctly apply gap detection techniques for tinnitus assessment in laboratory animals. The major categories of these issues include: refinement of hardware for best performance, optimization of stimulus parameters, behavioral considerations, and identification of optimal strategies for data analysis. This article is part of a Special Issue entitled: Tinnitus Neuroscience. Copyright © 2012. Published by Elsevier B.V.

  18. Euthanasia: Global Scenario and Its Status in India.

    PubMed

    Shekhawat, Raghvendra Singh; Kanchan, Tanuj; Setia, Puneet; Atreya, Alok; Krishan, Kewal

    2018-04-01

    The legal and moral validity of euthanasia has been questioned in different situations. In India, the status of euthanasia is no different. It was the Aruna Ramachandra Shanbaug case that got significant public attention and led the Supreme Court of India to initiate detailed deliberations on the long ignored issue of euthanasia. Realising the importance of this issue and considering the ongoing and pending litigation before the different courts in this regard, the Ministry of Health and Family Welfare, Government of India issued a public notice on May 2016 that invited opinions from the citizens and the concerned stakeholders on the proposed draft bill entitled The Medical Treatment of Terminally Ill Patients (Protection of Patients and Medical Practitioners) Bill. Globally, only a few countries have legislation with discreet and unambiguous guidelines on euthanasia. The ongoing developments have raised a hope of India getting a discreet law on euthanasia in the future.

  19. Using an Interdisciplinary Approach to Teach About Climate Change

    NASA Astrophysics Data System (ADS)

    Schafer, K.; Spenner, C.

    2017-12-01

    The traditional methods of teaching science, or any particular discipline, are not necessarily well suited for preparing students to solve big messy problems like sustainable development, climate change and resource management. We have developed a summer course entitled, "Human Ecology: Our Place in Nature," with the goal of addressing such issues through a series of case studies. The goal of these case studies is to explore how people interact with nature through Agriculture, Fisheries and Energy Use issues and could easily be adapted to specific geographical regions with different land use challenges. The course was divided into two segments: the first took place at locations near our school in San Jose, California and the second piece at various locations in Southeastern Alaska. Students learned about the interdisciplinary nature of these issues and developed an individual project of their choosing to explore some aspect of the course in greater depth.

  20. Imaging opioid analgesia in the human brain and its potential relevance for understanding opioid use in chronic pain

    PubMed Central

    Lee, Michael C.; Wanigasekera, Vishvarani; Tracey, Irene

    2014-01-01

    Opioids play an important role for the management of acute pain and in palliative care. The role of long-term opioid therapy in chronic non-malignant pain remains unclear and is the focus of much clinical research. There are concerns regarding analgesic tolerance, paradoxical pain and issues with dependence that can occur with chronic opioid use in the susceptible patient. In this review, we discuss how far human neuroimaging research has come in providing a mechanistic understanding of pain relief provided by opioids, and suggest avenues for further studies that are relevant to the management of chronic pain with opioids. This article is part of the Special Issue Section entitled ‘Neuroimaging in Neuropharmacology’. PMID:23891639

  1. Securities and Exchange Commission's regulation of public utility holding companies: an evaluation of Commission comments on a critical report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Staats, E.B.

    1978-01-04

    A report entitled: The Force of the Public Utility Holding Company Act Has Been Greatly Reduced By Changes in the Securities and Exchange Commission's Enforcement Policies, was issued June 20, 1977 by the GAO. The report raised questions concerning the narrowness of the Commission's administration of a statute which the Congress had intended to be wide-ranging and pervasive. On June 30, 1977, the Securities and Exchange Commission issued comments rejecting all of the reports recommendations. This report summarizes the findings of GAO's earlier report. GAO's evaluation of the Commission comments is presented in Appendix I and the Commission's comments aremore » presented in Appendix II.« less

  2. 20 CFR 410.202 - Duration of entitlement; miner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Duration of entitlement; miner. 410.202 Section 410.202 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Requirements for Entitlement; Duration of Entitlement...

  3. 20 CFR 410.202 - Duration of entitlement; miner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; miner. 410.202 Section 410.202 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Requirements for Entitlement; Duration of Entitlement...

  4. 20 CFR 410.201 - Conditions of entitlement; miner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Conditions of entitlement; miner. 410.201 Section 410.201 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Requirements for Entitlement; Duration of Entitlement...

  5. 20 CFR 410.201 - Conditions of entitlement; miner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conditions of entitlement; miner. 410.201 Section 410.201 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Requirements for Entitlement; Duration of Entitlement...

  6. Academic Entitlement: Relations to Perceptions of Parental Warmth and Psychological Control

    ERIC Educational Resources Information Center

    Turner, Lisa A.; McCormick, Wesley H.

    2018-01-01

    Academic entitlement characterises students who expect positive academic outcomes without personal effort. The current study examined the relations of perceived parental warmth and parental psychological control with two dimensions of academic entitlement (i.e., entitled expectations and externalised responsibility) among college students.…

  7. Investigating ion channel conformational changes using voltage clamp fluorometry.

    PubMed

    Talwar, Sahil; Lynch, Joseph W

    2015-11-01

    Ion channels are membrane proteins whose functions are governed by conformational changes. The widespread distribution of ion channels, coupled with their involvement in most physiological and pathological processes and their importance as therapeutic targets, renders the elucidation of these conformational mechanisms highly compelling from a drug discovery perspective. Thanks to recent advances in structural biology techniques, we now have high-resolution static molecular structures for members of the major ion channel families. However, major questions remain to be resolved about the conformational states that ion channels adopt during activation, drug modulation and desensitization. Patch-clamp electrophysiology has long been used to define ion channel conformational states based on functional criteria. It achieves this by monitoring conformational changes at the channel gate and cannot detect conformational changes occurring in regions distant from the gate. Voltage clamp fluorometry involves labelling cysteines introduced into domains of interest with environmentally sensitive fluorophores and inferring structural rearrangements from voltage or ligand-induced fluorescence changes. Ion channel currents are monitored simultaneously to verify the conformational status. By defining real time conformational changes in domains distant from the gate, this technique provides unexpected new insights into ion channel structure and function. This review aims to summarise the methodology and highlight recent innovative applications of this powerful technique. This article is part of the Special Issue entitled 'Fluorescent Tools in Neuropharmacology'. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Stem cells and bone diseases: new tools, new perspective.

    PubMed

    Riminucci, Mara; Remoli, Cristina; Robey, Pamela G; Bianco, Paolo

    2015-01-01

    Postnatal skeletal stem cells are a unique class of progenitors with biological properties that extend well beyond the limits of stemness as commonly defined. Skeletal stem cells sustain skeletal tissue homeostasis, organize and maintain the complex architectural structure of the bone marrow microenvironment and provide a niche for hematopoietic progenitor cells. The identification of stem cells in the human post-natal skeleton has profoundly changed our approach to the physiology and pathology of this system. Skeletal diseases have been long interpreted essentially in terms of defective function of differentiated cells and/or abnormal turnover of the matrix that they produce. The notion of a skeletal stem cell has brought forth multiple, novel concepts in skeletal biology that provide potential alternative concepts. At the same time, the recognition of the complex functions played by skeletal progenitors, such as the structural and functional organization of the bone marrow, has provided an innovative, unifying perspective for understanding bone and bone marrow changes simultaneously occurring in many disorders. Finally, the possibility to isolate and highly enrich for skeletal progenitors, enables us to reproduce perfectly normal or pathological organ miniatures. These, in turn, provide suitable models to investigate and manipulate the pathogenetic mechanisms of many genetic and non-genetic skeletal diseases. This article is part of a Special Issue entitled Stem cells and Bone. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Helix formation and stability in membranes.

    PubMed

    McKay, Matthew J; Afrose, Fahmida; Koeppe, Roger E; Greathouse, Denise V

    2018-02-13

    In this article we review current understanding of basic principles for the folding of membrane proteins, focusing on the more abundant alpha-helical class. Membrane proteins, vital to many biological functions and implicated in numerous diseases, fold into their active conformations in the complex environment of the cell bilayer membrane. While many membrane proteins rely on the translocon and chaperone proteins to fold correctly, others can achieve their functional form in the absence of any translation apparatus or other aides. Nevertheless, the spontaneous folding process is not well understood at the molecular level. Recent findings suggest that helix fraying and loop formation may be important for overall structure, dynamics and regulation of function. Several types of membrane helices with ionizable amino acids change their topology with pH. Additionally we note that some peptides, including many that are rich in arginine, and a particular analogue of gramicidin, are able passively to translocate across cell membranes. The findings indicate that a final protein structure in a lipid-bilayer membrane is sequence-based, with lipids contributing to stability and regulation. While much progress has been made toward understanding the folding process for alpha-helical membrane proteins, it remains a work in progress. This article is part of a Special Issue entitled: Emergence of Complex Behavior in Biomembranes edited by Marjorie Longo. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. Sex, rebellion and decadence: the scandalous evolutionary history of the human Y chromosome.

    PubMed

    Navarro-Costa, Paulo

    2012-12-01

    It can be argued that the Y chromosome brings some of the spirit of rock&roll to our genome. Equal parts degenerate and sex-driven, the Y has boldly rebelled against sexual recombination, one of the sacred pillars of evolution. In evolutionary terms this chromosome also seems to have adopted another of rock&roll's mottos: living fast. Yet, it appears to have refused to die young. In this manuscript the Y chromosome will be analyzed from the intersection between structural, evolutionary and functional biology. Such integrative approach will present the Y as a highly specialized product of a series of remarkable evolutionary processes. These led to the establishment of a sex-specific genomic niche that is maintained by a complex balance between selective pressure and the genetic diversity introduced by intrachromosomal recombination. Central to this equilibrium is the "polish or perish" dilemma faced by the male-specific Y genes: either they are polished by the acquisition of male-related functions or they perish via the accumulation of inactivating mutations. Thus, understanding to what extent the idiosyncrasies of Y recombination may impact this chromosome's role in sex determination and male germline functions should be regarded as essential for added clinical insight into several male infertility phenotypes. This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Entitlement to concessionary public transport and wellbeing: a qualitative study of young people and older citizens in London, UK.

    PubMed

    Jones, Alasdair; Goodman, Anna; Roberts, Helen; Steinbach, Rebecca; Green, Judith

    2013-08-01

    Access to transport is an important determinant of health, and concessionary fares for public transport are one way to reduce the 'transport exclusion' that can limit access. This paper draws on qualitative data from two groups typically at risk of transport exclusion: young people (12-18 years of age, n = 118) and older citizens (60+ years of age, n = 46). The data were collected in London, UK, where young people and older citizens are currently entitled to concessionary bus travel. We focus on how this entitlement is understood and enacted, and how different sources of entitlement mediate the relationship between transport and wellbeing. Both groups felt that their formal entitlement to travel for free reflected their social worth and was, particularly for older citizens, relatively unproblematic. The provision of a concessionary transport entitlement also helped to combat feelings of social exclusion by enhancing recipients' sense of belonging to the city and to a 'community'. However, informal entitlements to particular spaces on the bus reflected less valued social attributes such as need or frailty. Thus in the course of travelling by bus the enactment of entitlements to space and seats entailed the negotiation of social differences and personal vulnerabilities, and this carried with it potential threats to wellbeing. We conclude that the process, as well as the substance, of entitlement can mediate wellbeing; and that where the basis for providing a given entitlement is widely understood and accepted, the risks to wellbeing associated with enacting that entitlement will be reduced. Copyright © 2012 Elsevier Ltd. All rights reserved.

  12. 14 CFR 36.6 - Incorporation by reference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... No. 179, entitled “Precision Sound Level Meters,” dated 1973. (ii) IEC Publication No. 225, entitled... 1966. (iii) IEC Publication No. 651, entitled “Sound Level Meters,” first edition, dated 1979. (iv) IEC... edition, dated 1976. (v) IEC Publication No. 804, entitled “Integrating-averaging Sound Level Meters...

  13. 42 CFR 411.163 - Coordination of benefits: Dual entitlement situations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Coordination of benefits: Dual entitlement... Health Plans § 411.163 Coordination of benefits: Dual entitlement situations. (a) Basic rule. Coordination of benefits is governed by this section if an individual is eligible for or entitled to Medicare...

  14. 42 CFR 411.163 - Coordination of benefits: Dual entitlement situations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Coordination of benefits: Dual entitlement... Health Plans § 411.163 Coordination of benefits: Dual entitlement situations. (a) Basic rule. Coordination of benefits is governed by this section if an individual is eligible for or entitled to Medicare...

  15. 42 CFR 411.163 - Coordination of benefits: Dual entitlement situations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Coordination of benefits: Dual entitlement... Health Plans § 411.163 Coordination of benefits: Dual entitlement situations. (a) Basic rule. Coordination of benefits is governed by this section if an individual is eligible for or entitled to Medicare...

  16. 42 CFR 411.163 - Coordination of benefits: Dual entitlement situations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Coordination of benefits: Dual entitlement... Health Plans § 411.163 Coordination of benefits: Dual entitlement situations. (a) Basic rule. Coordination of benefits is governed by this section if an individual is eligible for or entitled to Medicare...

  17. 42 CFR 411.163 - Coordination of benefits: Dual entitlement situations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Coordination of benefits: Dual entitlement... Health Plans § 411.163 Coordination of benefits: Dual entitlement situations. (a) Basic rule. Coordination of benefits is governed by this section if an individual is eligible for or entitled to Medicare...

  18. PREFACE Surface Modifications and Functionalization of Materials for Biomedical Applications

    NASA Astrophysics Data System (ADS)

    Endrino, Jose Luis; Puértolas, Jose A.; Albella, Jose M.

    2010-11-01

    Conference photograph This special issue contains selected papers which were presented as invited and contributed communications at the workshop entitled 'Surface modification and functionalization of materials for biomedical applications' (BIO-COAT 2010) which was held on 24 June 2010 in Zaragoza (Spain). The surface of a material plays a major role in its interaction with the biological medium. Processes related to the mechanical stability of articular devices in contact, osseointegration, thrombogenicity, corrosion and leaching, or the inflammatory response of rejection of a material, are clearly conditioned by the surface properties. Therefore, the modification or functionalization of surfaces can have an important impact on these issues. New techniques for functionalization by thin film deposition or surface treatments help to improve superficial properties, while understanding the interaction of the surface-biological medium is critical for their application in new devices. Jointly organized by the Spanish Materials Research Society, BIO-COAT 2010 provided an open forum to discuss the progress and latest developments in thin film processing and the engineering of biomaterials. Invited lectures were particularly aimed at providing overviews on scientific topics and were given by recognized world-class scientists. Two of them have contributed with a proceedings article to this selected collection (articles 012001 and 012008). The contributed communications were focused on particular cutting-edge aspects of thin film science and functionalization technologies for biomaterials, showing the major scientific push of Spanish research groups in the field. The 2010 BIO-COAT conference was organized along four main topics: (1) functionalization and texture on surfaces, (2) tribology and corrosion, (3) the surface modification of biomaterials, and (4) surface-biological environment interactions. The papers published in this volume were accepted for publication after peer-review as are regular papers. The editor of this proceedings volume gratefully acknowledges all referees for their valuable work, sometimes working to quite short deadlines. Finally, BIO-COAT 2010 would not have been successful without the strong involvement and input of the local organizing committee in Zaragoza, and the support of the University of Zaragoza. We sincerely thank them all for their efforts. Jose L Endrino (Editor) Jose A Puértolas (Chairman) Jose M Albella (Chairman)

  19. Water channel structures analysed by electron crystallography.

    PubMed

    Tani, Kazutoshi; Fujiyoshi, Yoshinori

    2014-05-01

    The mechanisms underlying water transport through aquaporin (AQP) have been debated for two decades. The water permeation phenomenon of AQP seems inexplicable because the Grotthuss mechanism does not allow for simultaneous fast water permeability and inhibition of proton transfer through the hydrogen bonds of water molecules. The AQP1 structure determined by electron crystallography provided the first insights into the proton exclusion mechanism despite fast water permeation. Although several studies have provided clues about the mechanism based on the AQP structure, each proposed mechanism remains incomplete. The present review is focused on AQP function and structure solved by electron crystallography in an attempt to fill the gaps between the findings in the absence and presence of lipids. Many AQP structures can be superimposed regardless of the determination method. The AQP fold is preserved even under conditions lacking lipids, but the water arrangement in the channel pore differs. The differences might be explained by dipole moments formed by the two short helices in the lipid bilayer. In addition, structure analyses of double-layered two-dimensional crystals of AQP suggest an array formation and cell adhesive function. Electron crystallography findings not only have contributed to resolve some of the water permeation mechanisms, but have also elucidated the multiple functions of AQPs in the membrane. The roles of AQPs in the brain remain obscure, but their multiple activities might be important in the regulation of brain and other biological functions. This article is part of a Special Issue entitled Aquaporins. © 2013.

  20. Reflex epileptic mechanisms in humans: Lessons about natural ictogenesis.

    PubMed

    Wolf, Peter

    2017-06-01

    The definition of reflex epileptic seizures is that specific seizure types can be triggered by certain sensory or cognitive stimuli. Simple triggers are sensory (most often visual, more rarely tactile or proprioceptive; simple audiogenic triggers in humans are practically nonexistent) and act within seconds, whereas complex triggers like praxis, reading and talking, and music are mostly cognitive and work within minutes. The constant relation between a qualitatively, often even quantitatively, well-defined stimulus and a specific epileptic response provides unique possibilities to investigate seizure generation in natural human epilepsies. For several reflex epileptic mechanisms (REMs), this has been done. Reflex epileptic mechanisms have been reported less often in focal lesional epilepsies than in idiopathic "generalized" epilepsies (IGEs) which are primarily genetically determined. The key syndrome of IGE is juvenile myoclonic epilepsy (JME), where more than half of the patients present reflex epileptic traits (photosensitivity, eye closure sensitivity, praxis induction, and language-induced orofacial reflex myocloni). Findings with multimodal investigations of cerebral function concur to indicate that ictogenic mechanisms in IGEs largely (ab)use preexisting functional anatomic networks (CNS subsystems) normally serving highly complex physiological functions (e.g., deliberate complex actions and linguistic communication) which supports the concept of system epilepsy. Whereas REMs in IGEs, thus, are primarily function-related, in focal epilepsies, they are primarily localization-related. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic". Copyright © 2015 Elsevier Inc. All rights reserved.

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