Sample records for ivar jrving tnis

  1. Thermophysical Model of S-complex NEAs: 1627 Ivar

    NASA Astrophysics Data System (ADS)

    Crowell, Jenna; Howell, Ellen S.; Magri, Christopher; Fernandez, Yanga R.; Marshall, Sean E.; Warner, Brian D.; Vervack, Ronald J., Jr.


    We present an updated thermophysical model of 1627 Ivar, an Amor class near Earth asteroid (NEA) with a taxonomic type of Sqw [1]. Ivar's large size and close approach to Earth in 2013 (minimum distance 0.32 AU) provided an opportunity to observe the asteroid over many different viewing angles for an extended period of time, which we have utilized to generate a shape and thermophysical model of Ivar, allowing us to discuss the implications that these results have on the regolith of this asteroid. Using the software SHAPE [2,3], we updated the nonconvex shape model of Ivar, which was constructed by Kaasalainen et al. [4] using photometry. We incorporated 2013 radar data and CCD lightcurves using the Arecibo Observatory's 2380Mz radar and the 0.35m telescope at the Palmer Divide Station respectively, to create a shape model with higher surface detail. We found Ivar to be elongated with maximum extended lengths along principal axes of 12 x 5 x 6 km and a rotation rate of 4.795162 ± 5.4 * 10-6 hrs [5]. In addition to these radar data and lightcurves, we also observed Ivar in the near IR using the SpeX instrument at the NASA IRTF. These data cover a wide range of Ivar's rotational longitudes and viewing geometries. We have used SHERMAN [6,7] with input parameters such as the asteroid's IR emissivity, optical scattering law, and thermal inertia, in order to complete thermal computations based on our shape model and known spin state. Using this procedure, we find which reflective, thermal, and surface properties best reproduce the observed spectra. This allows us to characterize properties of the asteroid's regolith and study heterogeneity of the surface. We will compare these results with those of other S-complex asteroids to better understand this asteroid type and the uniqueness of 1627 Ivar.[1] DeMeo et al. 2009, Icarus 202, 160-180 [2] Magri, C. et al. 2011, Icarus 214, 210-227. [3] Crowell, J. et al. 2014, AAS/DPS 46 [4] Kaasalainen, M. et al. 2004, Icarus 167, 178

  2. Ole Ivar Lovaas--His Life, Merits and Legacy

    ERIC Educational Resources Information Center

    Özerk, Kamil; Vea, Gunvor Dalby; Eikeseth, Svein; Özerk, Meral


    Ole Ivar Lovaas (1927-2010) is known worldwide for his research within the field of Applied Behavior Analysis, and is probably the most influential researcher within the field of treatment of children with autism. In the first part of this biographically oriented paper, we inform the readers about his family background, childhood, elementary and…

  3. Thermophysical Model of S-complex NEAs: 1627 Ivar

    NASA Astrophysics Data System (ADS)

    Crowell, Jenna L.; Howell, Ellen S.; Magri, Christopher; Fernandez, Yan R.; Marshall, Sean E.; Warner, Brian D.; Vervack, Ronald J.


    We present updates to the thermophysical model of asteroid 1627 Ivar. Ivar is an Amor class near Earth asteroid (NEA) with a taxonomic type of Sqw [1] and a rotation rate of 4.795162 ± 5.4 * 10-6 hours [2]. In 2013, our group observed Ivar in radar, in CCD lightcurves, and in the near-IR’s reflected and thermal regimes (0.8 - 4.1 µm) using the Arecibo Observatory’s 2380 MHz radar, the Palmer Divide Station’s 0.35m telescope, and the SpeX instrument at the NASA IRTF respectively. Using these radar and lightcurve data, we generated a detailed shape model of Ivar using the software SHAPE [3,4]. Our shape model reveals more surface detail compared to earlier models [5] and we found Ivar to be an elongated asteroid with the maximum extended length along the three body-fixed coordinates being 12 x 11.76 x 6 km. For our thermophysical modeling, we have used SHERMAN [6,7] with input parameters such as the asteroid’s IR emissivity, optical scattering law and thermal inertia, in order to complete thermal computations based on our shape model and the known spin state. We then create synthetic near-IR spectra that can be compared to our observed spectra, which cover a wide range of Ivar’s rotational longitudes and viewing geometries. As has been noted [6,8], the use of an accurate shape model is often crucial for correctly interpreting multi-epoch thermal emission observations. We will present what SHERMAN has let us determine about the reflective, thermal, and surface properties for Ivar that best reproduce our spectra. From our derived best-fit thermal parameters, we will learn more about the regolith, surface properties, and heterogeneity of Ivar and how those properties compare to those of other S-complex asteroids. References: [1] DeMeo et al. 2009, Icarus 202, 160-180 [2] Crowell, J. et al. 2015, LPSC 46 [3] Magri C. et al. 2007, Icarus 186, 152-177 [4] Crowell, J. et al. 2014, AAS/DPS 46 [5] Kaasalainen, M. et al. 2004, Icarus 167, 178-196 [6] Crowell, J. et

  4. Understanding the Importance of Shape in Thermal Modeling: The Case of 1627 Ivar

    NASA Astrophysics Data System (ADS)

    Crowell, Jenna L.; Howell, Ellen S.; Magri, Christopher; Fernandez, Yanga R.; Nolan, Michael C.; Vervack, Ronald J., Jr.; Marshall, Sean E.


    We seek to investigate the compositional surface variation of near Earth asteroids (NEAs). To do this, we employ detailed shape models and near-IR observations, taken over a range of viewing geometries, in order to create thermophysical models. The thermal spectra are therefore linked to regions on the asteroid, and we can seek out a set of thermal parameters that are capable of reproducing the thermal spectra over the entirety of the asteroid's surface. This method also enables us to characterize portions of the asteroid that may have different thermal properties than other regions, in which case there is no single set of thermal parameters that satisfy all of the thermal observations, indicating a heterogeneous surface.We present our findings on 1627 Ivar, an Amor class NEA with a taxonomic type of Sqw [1], and a rotation period of 4.7951689 hr ± 0.0000026 [2]. During Ivar's apparition in 2013, we obtained CCD lightcurves, radar data, and near-IR spectra. Using the software SHAPE, we have used lightcurve and radar data to generate an improved shape model of Ivar [2][3].For the thermophysical modeling, we have used SHERMAN [3,4] to determine which reflective, thermal, and surface properties for Ivar best reproduce our spectra, taken using the SpeX instrument at the NASA IRTF [5]. Input parameters for SHERMAN include the asteroid's IR emissivity, optical scattering law and thermal inertia in order to complete thermal computations based on the shape model. We also compare these results to those created by using the Kaasalainen lightcurve model [6]. Since models created from lightcurve inversion techniques far outnumber those created using radar data, it is important to understand how these two models differ when studying thermal models.References: [1] DeMeo et al. 2009, Icarus 202, 160-180 [2] Crowell et al. 2016, Icarus, in press [3] Crowell et al. 2014, AAS/DPS 46 [4] Howell et al. 2015, AAS/DPS 47 [5] Rayner et al. 2003, PASP 115, 362 [6] Kaasalainen et al. 2004

  5. Physical studies of Apollo-Amor asteroids - UBVRI photometry of 1036 Ganymed and 1627 Ivar

    NASA Technical Reports Server (NTRS)

    Hahn, G.; Magnusson, P.; Harris, A. W.; Young, J. W.; Belkora, L. A.


    The 1036 Ganymed and 1627 Ivar photoelectric lightcurves presently discussed indicate in the former case a drastic lightcurve shape change, in conjunction with a significant increase of the synodic rotation period; a substantial change in viewing conditions during the apparition, and a complex interaction between these changes and the asteroid's irregular shape, are indicated by the change. In the latter asteroid's case, a prograde rotation rate is apparent in the observed decrease in synodic period. Both asteroids' phase curves exhibit deviations from the H-G magnitude system phase function at large phase angles.

  6. O. Ivar lovaas: pioneer of applied behavior analysis and intervention for children with autism.


    Smith, Tristram; Eikeseth, Svein


    O. Ivar Lovaas (1927-2010) devoted nearly half a century to ground-breaking research and practice aimed at improving the lives of children with autism and their families. In the 1960s, he pioneered applied behavior analytic (ABA) interventions to decrease severe challenging behaviors and establish communicative language. Later, he sought to improve outcomes by emphasizing early intervention for preschoolers with autism, provided in family homes with active parental participation. His studies indicated that many children who received early intensive ABA made dramatic gains in development. Lovaas also disseminated ABA widely through intervention manuals, educational films, and public speaking. Moreover, as an enthusiastic teacher and devoted mentor, he inspired many students and colleagues to enter the field of ABA and autism intervention.

  7. Brain Mapper and IVAR

    NASA Technical Reports Server (NTRS)


    The Human Engineering Methods (HEM) Research Laboratory is utilized for the development of human-response measurement technologies to assess the effects of advanced crew station concepts on the crews ability to perform flight-management tasks effectively. Behavioral response and psychophysiological response measurement systems have been developed to assess mental loading, stress, task engagement, and situation awareness. Measurement capabilities include topographic brainmapping (EEG and evoked responses), monitoring of pulse, heart and muscle electrical activity (EKG and EMG), skin temperature and conductance, respiration, and tracking of eye lookpoint (oculometry) and overt behavior (video analysis). A real-time multiattribute task (MAT) battery has been developed to recreate flight-management task conditions in the laboratory setting for initial testing of advanced human-response measurement concepts. Mobile physiological monitoring and behavioral response capture-stations are located at simulator sites to refine these measurement concepts for flight-management research.

  8. Integration and Validation of Avian Radars (IVAR)

    DTIC Science & Technology


    operations; 1-year visual census; multiple eBirdRad radars; fiber- optic wired LAN (planned) NAS Patuxent River, MD X B X Medium-sized air station...introduced a multibeam avian radar antenna that purports to double the beam width (from 4° to 8°), while at the same time increasing the precision of the

  9. Integration and Validation of Avian Radars (IVAR)

    DTIC Science & Technology


    controlled for unattended operations, and that they can detect 50 times more birds than human observers using conventional visual methods . Finally...number. These manual radar signal processing methods , while effective in improving bird detection , especially at night when visual methods are...criterion for the qualitative PA1.2 criterion that the detection and tracking of these targets would be “Achievable”. Methods We chose to demonstrate

  10. Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion

    PubMed Central

    Barnes, Dawn E.; Hwang, Hyundoo; Ono, Kanako; Lu, Hang; Ono, Shoichiro


    Summary The troponin complex, composed of troponin T (TnT), troponin I (TnI), and troponin C (TnC), is the major calcium-dependent regulator of muscle contraction, which is present widely in both vertebrates and invertebrates. Little is known about evolutionary aspects of troponin in the animal kingdom. Using a combination of data mining and functional analysis of TnI, we report evidence that an N-terminal extension of TnI is present in most of bilaterian animals as a functionally important domain. Troponin components have been reported in species in most of representative bilaterian phyla. Comparison of TnI sequences shows that the core domains are conserved in all examined TnIs, and that N- and C-terminal extensions are variable among isoforms and species. In particular, N-terminal extensions are present in all protostome TnIs and chordate cardiac TnIs but lost in a subset of chordate TnIs including vertebrate skeletal-muscle isoforms. Transgenic rescue experiments in C. elegans striated muscle show that the N-terminal extension of TnI (UNC-27) is required for coordinated worm locomotion but not in sarcomere assembly and single muscle-contractility kinetics. These results suggest that N-terminal extensions of TnIs are retained from a TnI ancestor as a functional domain. PMID:26849746

  11. Development of the EURITRACK tagged neutron inspection system

    NASA Astrophysics Data System (ADS)

    Perot, B.; Carasco, C.; Bernard, S.; Mariani, A.; Szabo, J.-L.; Mercier, E.; Sannie, G.; Viesti, G.; Nebbia, G.; Pesente, S.; Lunardon, M.; Moretto, S.; Fabris, D.; Zenoni, A.; Bonomi, G.; Donzella, A.; Fontana, A.; Boghen, G.; Valkovic, V.; Sudac, D.; Moszynski, M.; Batsch, T.; Gierlik, M.; Woski, D.; Klamra, W.; Isaksson, P.; Le Tourneur, P.; Lhuissier, M.; Colonna, A.; Tintori, C.; Peerani, P.; Sequeira, V.; Salvato, M.


    The EURopean Illicit TRAfficing Countermeasures Kit (EURITRACK) project is part of the 6th European Union Framework Program. It aims at developing a Tagged Neutron Inspection System (TNIS) to detect illicit materials, such as explosives and narcotics, in cargo containers. Fast neutron induced reactions produce specific gamma-rays used to determine the chemical composition of the inspected material. The associated particle technique is employed to precisely locate the interaction points of the neutrons. A new deuterium-tritium neutron generator has been developed, including a pixelized alpha particle detector. The TNIS also comprises high-efficiency fast neutron and gamma-ray detectors, a dedicated front-end electronics and an integrated software to entirely drive the system and automatically process the data. Most components have been integrated during last months at Institute Ruder Boskovic, in Zagreb, Croatia. An overview of the TNIS and of its preliminary performances is presented.

  12. The slow isoform of Xenopus troponin I is expressed in developing skeletal muscle but not in the heart.


    Warkman, Andrew S; Atkinson, Burr G


    In birds and mammals three isoforms of troponin I (TnI) exist; a slow (TnIs), a fast (TnIf) and a cardiac (TnIc). Although each of these isoforms is expressed in the adult forms of these organisms in a muscle fiber-type-specific manner, the gene encoding TnIs is also expressed within the developing heart of these vertebrates. Herein, our results demonstrate that the developing heart of Xenopus laevis, unlike its counterpart in birds and mammals, does not express the gene encoding the TnIs isoform and that the expression of this gene, as well as the one encoding the Xenopus TnIf isoform, is restricted to skeletal muscle.

  13. Criteria for Reconstitution of Forces.

    DTIC Science & Technology


    proposed. ,.. nceS’ F For NTIS CQ𔃽*! DTI~C Vi LI Just If .ut - . ion_ .. ".. D 1lI T . .. .. .. ... AVAt 1 " t’ ’. Dist SIRCURITY CLASSIFICATION OF TNIS...the CGSC sample had combat experience, an average of 14 months. Only 4 percent of the Advanced Course respondents, who were mostly captains , reported

  14. Nerve-responsive troponin I slow promoter does not respond to unloading

    NASA Technical Reports Server (NTRS)

    Criswell, D. S.; Hodgson, V. R.; Hardeman, E. C.; Booth, F. W.


    We examined the regulation of the troponin I slow (TnIs) promoter during skeletal muscle unloading-induced protein isoform transition, by using a transgenic mouse line harboring the -4,200 to +12 base pairs region of the human TnIs promoter. Eighteen female transgenic mice ( approximately 30 g body mass) were randomly divided into two groups: weight-bearing (WB) controls (n = 9) and hindlimb unloaded (HU; n = 9). The HU mice were tail suspended for 7 days. Body mass was unchanged in the WB group but was reduced (-6%; P < 0.05) after the HU treatment. Absolute soleus muscle mass (-25%) and soleus mass relative to body mass (-16%) were both lower (P < 0.05) in the HU group compared with the WB mice. Northern blot analyses indicate that 7 days of HU result in a 64% decrease (P < 0.05) in the abundance of endogenous TnIs mRNA (microg/mg muscle) in the mouse soleus. Furthermore, there is a trend for the abundance of the fast troponin I mRNA to be increased (+34%). Analysis of transgenic chloramphenicol acetyltransferase activity in the soleus muscle revealed no difference (P > 0.05) between WB and HU groups. We conclude that additional elements are necessary for the TnIs gene to respond to an unloading-induced, slow-to-fast isoform transition stimulus.

  15. Electron Resonance Decay into a Biological Function: Decrease in Viability of E. coli Transformed by Plasmid DNA Irradiated with 0.5-18 eV Electrons.


    Kouass Sahbani, S; Cloutier, P; Bass, A D; Hunting, D J; Sanche, L


    Transient negative ions (TNIs) are ubiquitous in electron-molecule scattering at low electron impact energies (0-20 eV) and are particularly effective in damaging large biomolecules. Because ionizing radiation generates mostly 0-20 eV electrons, TNIs are expected to play important roles in cell mutagenesis and death during radiotherapeutic cancer treatment, although this hypothesis has never been directly verified. Here, we measure the efficiency of transforming E. coli bacteria by inserting into the cells, pGEM-3ZfL(-) plasmid DNA that confers resistance to the antibiotic ampicillin. Before transformation, plasmids are irradiated with electrons of specific energies between 0.5 and 18 eV. The loss of transformation efficiency plotted as a function of irradiation energy reveals TNIs at 5.5 and 9.5 eV, corresponding to similar states observed in the yields of DNA double strand breaks. We show that TNIs are detectable in the electron-energy dependence of a biological process and can decrease cell viability.

  16. Logic Design of a Shared Disk System in a Multi-Micro Computer Environment.

    DTIC Science & Technology


    thesis was essential to the project. Chapter II addresses tne system arcnitecture. Detailed discussion is eiven of all major hardware components as...tne development of tne vicropoiis interface design. A eeneral understandin? of tnis structure is an essential prerequiste to an understanding of,bin_dec,dec_asc • subroutine prints out at tne console a bulation of user supplied input and tne calling program

  17. Scanning Cargo Containers with Tagged Neutrons

    SciTech Connect

    Viesti, G.; Botosso, C.; Fabris, D.; Lunardon, M.; Moretto, S.; Nebbia, G.; Pesente, S.; Zenoni, A.; Donzella, A.; Perot, B.; Carasco, C.; Bernard, S.; Mariani, A.; Szabo, J.-L.; Sannie, G.; Valkovic, V.; Sudac, D.; Nad, K.; Peerani, P.; Sequeira, V.


    A new Tagged Neutron Inspection System (TNIS) able to detect illicit materials such as explosives and narcotics in cargo containers has been developed within the EURopean Illicit TRAfficing Countermeasures Kit (EURITRACK) project. After the R and D phase, the inspection portal has been installed and commissioned at the Rijeka seaport in Croatia, where it has been operated in connection with the existing X-ray scanner for a first two-month demonstration campaign. Results obtained are presented and discussed in this paper.

  18. Scanning Cargo Containers with Tagged Neutrons

    NASA Astrophysics Data System (ADS)

    Viesti, G.; Botosso, C.; Fabris, D.; Lunardon, M.; Moretto, S.; Nebbia, G.; Pesente, S.; Zenoni, A.; Donzella, A.; Perot, B.; Carasco, C.; Bernard, S.; Mariani, A.; Szabo, J.-L.; Sannie, G.; Valkovic, V.; Sudac, D.; Nad, K.; Peerani, P.; Sequeira, V.; Salvato, M.; Moszynski, M.; Gierlik, M.; Klamra, W.; Le Tourneur, P.; Lhuissier, M.; Colonna, A.; Tintori, C.


    A new Tagged Neutron Inspection System (TNIS) able to detect illicit materials such as explosives and narcotics in cargo containers has been developed within the EURopean Illicit TRAfficing Countermeasures Kit (EURITRACK) project. After the R&D phase, the inspection portal has been installed and commissioned at the Rijeka seaport in Croatia, where it has been operated in connection with the existing X-ray scanner for a first two-month demonstration campaign. Results obtained are presented and discussed in this paper.

  19. The Effect of Remote Sensor Spatial Resolution in Monitoring U.S. Army Training Maneuver Sites

    DTIC Science & Technology


    at Pinon Canyon and the abbreviations used in tnis research. 68 BOGR /HIJA 10-20% COVER Blue grama (Bouteloua gracilis) and Galleta (Hilaria 1 amesii...approximately 10-20% ground cover. BOGR /AGSM/HIJA 20-30% Blue grama (Bouteloua COVER gracilis) , Western wheatgrass (Agropyron smithii) and Galleta...Hilaria Jamesii), approximately 20-30% ground cover. BOGR /SPAI/HIJA 30-40% Blue grama (Bouteloua COVER gracilis), Alkali sacaton (Sporobolus airoides

  20. Compilation of Reprints Number 63.

    DTIC Science & Technology


    uO*-54 603 ICURITY CLASSIFICATION O0P TNIS PAGE (ft" 001- 010.01 Uc I ass i ,.d sa masi CLAsSIFICATzoui or mi$ PlCTiwnlho base rd depends on...1982). Elastic Scattering (ES). The categorizing of these interactions his facilitated the mathematical treatment as well as discussions of Dynamics...and medical sciences. Interstate Printers and Pub- lishers. Danville. III. 171 pp. University of Washington, Department of Oceanography. 1980. FRONTS

  1. Liquid Surface Levitation Holography. Part 1. Theoretical Analysis.

    DTIC Science & Technology


    Continued) ’ DD J AN 73 1473 EDITION OF INOV 65 IS OSSOLETE 0102-014-6601 SECURI1TY CLASSIFICATION OF TNIS PAGE (When, DIte Writoeed) Fig. 1. The acoustic energy from the object transducer passes into the object to be imaged and is diffracted, internally reflected, and attenuated...frequencies for a typical plastic membrane separating water and Freon E-5 (imaging fluid). Hence the energy in the internally reflected waves will

  2. A Microcomputer System for Target Information in the Fire Support Coordination Center: A Data Base Approach.

    DTIC Science & Technology


    space and lie speed of access to secondary storaee and. the requirement for an e..eftive interactive system for a non-sopbisticated user. The desian of...operator woriine in the SACC operational spaces uses tne QUEST data base query language to access targets and target information from the data base. Requests...display unit in the SACC. The report printouts are available from a printer located in the main computer spaces . During tnis period, the TIO is

  3. Low-Level Convergence and the Prediction of Convective Precipitation in South Florida.

    DTIC Science & Technology


    Af" -Ao97 55 ILLINOIS STATE WATER SURVEY URBANA F/6 4/2 LOWLEVEL CONVERGENCE AND THE PREDICTION OF CONVECTIVE PRECIPIT-ETC(U) FEB 81 A I WATSON. R L...not be construed as an official Department of the Army position, policy, or decision, unless so designated by other documentation. IS. KEY WORDS ...varying meteorological cond’tions and ti: == UNCLASSIFIED of day. SECURITY CLASSIFICATIOR OF TNIS PAGE (Whven Data Etered) State Water Survey

  4. Semidiurnal Hough Mode Extensions in the Thermosphere and Their Application

    DTIC Science & Technology


    OF TNIS PAGE (11t~n Veto Rnforod) ..- q4ITY CLASSIFICATION OF THIS PAGE(Whan Dae EFneld) 20. Abstract (Continued) solar cycle. This note gives the...will vary with solar cycle insofar as ion drag (proportional to electron density) and neutral temperature vary with the solar cycle. To present the...Reidel, Dordrecht, Holland, 200 pp. 2. Hong, S., and R. S. Lindzen, 1976, Solar Semidiurnal Tide in the Thermosphere. J. Atmos. Sci., a, in press. 3

  5. Distributed Hypothesis Formation in Distributed Sensor Networks

    DTIC Science & Technology


    the processing architecture at each node in the DSN. Each node contains the Generalized Tracker/Classifier for processing of (Continued) - DD 1473...TIM Olr TNiS PAG Iwhn D-le Ine 4e.) local sensor data, an information fusion module to integrate processed information from various nodes, and an...OF EACH PROCESSING NODE .. ............ 10 2.2.1 Local Processing of the Sensor Data. ......... 12 2.2.2 Information Fusion. .. ................ 12

  6. Stories of Discovery Stimulate the Physics Major--A Polemic, with Examples.

    ERIC Educational Resources Information Center

    Leitner, Alfred


    Provides historical examples of intuitive discovery applicable to the teaching of physics for majors. Cites details for the discovery of Coulomb's law, emphasizing the roles of Joseph Priestley and Henry Cavendish. Also discusses the career of Ivar Giaever, a Nobel Prize winner of 1973 in solid state physics. (CS)

  7. Aspects on Literacy: Selected Papers from the IRA World Congress on Reading (13th, Stockholm, Sweden, 1990). Linkoping Studies in Education and Psychology No. 34.

    ERIC Educational Resources Information Center

    Ericson, Britta, Ed.

    This book offers eight papers presented by specially invited delegates. The papers and their authors are as follows: "Dyslexia and Its Consequences in the Life of Dyslexics" (Hanna Jaklewicz); "Visually Related Reading Problems--Diagnosis and Treatment" (Ivar Lie); "How to Prevent Vision Problems among Children in…

  8. Transcriptional control of muscle plasticity: differential regulation of troponin I genes by electrical activity.


    Calvo, S; Stauffer, J; Nakayama, M; Buonanno, A


    Plasticity of the skeletal muscle phenotype can result from the selective repression and activation of gene expression in response to innervation patterns. Motoneurons, eliciting different patterns of depolarization, regulate the contractile properties of the myofibers they innervate by selectively activating expression of genes encoding fiber-type-specific (fast vs. slow) contractile proteins. We have analyzed the regulation of the troponin I slow (TnIs) and fast (TnIf) genes as a model to study the molecular mechanisms regulating fiber-type plasticity. We found that expression of the two TnI isoforms is downregulated by denervation. Moreover, TnI expression is upregulated by specific patterns of electrical activity [10 Hz vs. 100 Hz] used to depolarize muscle. We previously isolated the rat TnIs gene and demonstrated that regulatory sequences reside in its upstream region and second intron [Banerjee-Basu S, Buonanno A (1993), Mol Cell Biol 12:5024-5032]. Using transgenic mice, we show that the upstream region of the TnIs gene extending from -949 to +50 is sufficient to confer transcription specifically in slowtwitch muscles. Serial deletions of the TnIs upstream and intronic regions were generated in a CAT reporter vector to delineate transcriptional regulatory elements in transiently transfected Sol8 myotubes. Sequences necessary to confer the highest levels of TnIs transcription mapped to the upstream region between -0.95 and -0.72 kb, and to a 56 bp sequence located in the second intron. Comparison of the at sequence between -0.95 and -0.72 to the human TnIs gene identified a highly homologous region of 128 bp that we named the TnI SURE (slow upstream regulatory element). Alignment of these two SURE sequences with the quail TnI fast intronic regulatory element identified common motifs, namely, two A/T-rich sequences (A/T1 and A/T2) with homology to homeotic protein and MEF2 binding sites, a CACC box, an E box, and a novel motif (GCAGGCA) that we denoted the

  9. Tau-positive nuclear indentations in P301S tauopathy mice.


    Fernández-Nogales, Marta; Santos-Galindo, María; Merchán-Rubira, Jesús; Hoozemans, Jeroen J M; Rábano, Alberto; Ferrer, Isidro; Avila, Jesús; Hernández, Félix; Lucas, José J


    Increased incidence of neuronal nuclear indentations is a well-known feature of the striatum of Huntington's disease (HD) brains and, in Alzheimer's disease (AD), neuronal nuclear indentations have recently been reported to correlate with neurotoxicity caused by improper cytoskeletal/nucleoskeletal coupling. Initial detection of rod-shaped tau immunostaining in nuclei of cortical and striatal neurons of HD brains and in hippocampal neurons of early Braak stage AD led us to coin the term "tau nuclear rods (TNRs)." Although TNRs traverse nuclear space, they in fact occupy narrow cytoplasmic extensions that fill indentations of the nuclear envelope and we will here refer to this histological hallmark as Tau-immunopositive nuclear indentations (TNIs). We reasoned that TNI formation is likely secondary to tau alterations as TNI detection in HD correlates with an increase in total tau, particularly of the isoforms with four tubulin binding repeats (4R-tau). Here we analyze transgenic mice that overexpress human 4R-tau with a frontotemporal lobar degeneration-tau point mutation (P301S mice) to explore whether tau alteration is sufficient for TNI formation. Immunohistochemistry with various tau antibodies, immunoelectron microscopy and double tau-immunofluorescence/DAPI-nuclear counterstaining confirmed that excess 4R-tau in P301S mice is sufficient for the detection of abundant TNIs that fill nuclear indentations. Interestingly, this does not correlate with an increase in the number of nuclear indentations, thus suggesting that excess total tau or an isoform imbalance in favor of 4R-tau facilitates tau detection inside preexisting nuclear indentations but does not induce formation of the latter. In summary, here we demonstrate that tau alteration is sufficient for TNI detection and our results suggest that the neuropathological finding of TNIs becomes a possible indicator of increased total tau and/or increased 4R/3R-tau ratio in the affected neurons apart from being an

  10. Effects of Condensate Inundation and Vapor Velocity on Heat Transfer in a Condenser Tube Bundle.

    DTIC Science & Technology


    meter and the tank’s recirculation valve, the flow rate to the porous tube could be controlled with reasonable accuracy. The system was used to supply... flow rate of water to the desuper- heater spray nozzles via the rotameter. 150 5. Porous Tube Water Supply System a. Once steady state conditions have... system operated at test condenser pressures of approximately 2 and 15 DD ~T 1413 EmnTOw OF, I Nov o Is S OSLITe S/N 612.814-61 9CIT CLAGNIFICATIOM OF TNIS

  11. Environmental Impact Statement. Proposed Closure of Los Angeles AFB, California and Relocation of Space Systems Division. Appendix F. Public Comments

    DTIC Science & Technology



  12. Interface Characterization of Cu-Cu and Cu-Ag-Cu Low Temperature Solid State Bonds.

    DTIC Science & Technology


    produce low -. 0 onnos s boniecnstrated, the thrust o: tnis texann a ecne: onaractorlstics as a function c.: 4 time, temperature and pressure . The...conducted under y hyrostatic pressure to avoid deformation of the tensile specimen. At 2Cksi the tensile yield strength of the silver has been exceeded by...A19i 915 INTERFACE CHARACTERIZATION OF CU-CU AND CU-AG-CU LOW 1/1 TEMPERATURE SOLID STATE BONDS(U) NAVAL POSTGRADUATE SCHOO0L MONTEREY CA R Z DALBEY

  13. 2250-MHz High Efficiency Microwave Power Amplifier (HEMPA)

    NASA Technical Reports Server (NTRS)

    Sims, W. Herbert; Bell, Joseph L. (Technical Monitor)


    Tnis paper will focus on developing an exotic switching technique that enhances the DC-to-RF conversion efficiency of microwave power amplifiers. For years, switching techniques implemented in the 10 kHz to 30 MHz region have resulted in DC-to-RF conversion efficiencies of 90-95-percent. Currently amplifier conversion efficiency, in the 2-3 GHz region approaches, 10-20-percent. Using a combination of analytical modeling and hardware testing, a High Efficiency Microwave Power Amplifier was built that demonstrated conversion efficiencies four to five times higher than current state of the art.

  14. Array I Photo Imagery Analysis.

    DTIC Science & Technology


    stereo scan Ssearcn, was -ated 2s oeina: Detectaole i-I - rti iy Detectac’e 1 - ’ ion etectaole .A ’Ile Ŕ" rating means that one is capable of detecting...tures on a ohotograph. Another term "minimum ground seoaration ," :cmes into context for tnis iiscussion. This is the ininimum distance oetween ions sroula be notedi: 1. The brightness of the mine to be resolved; 2. The uniformity of the target background; and 3. The extent of the uniform

  15. Prince George Apt, British Columbia, Canada, Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    DTIC Science & Technology


    DO NOT REPRODUCE LEGIBLY. SEC,,RITY CASSIFICA ! ON OF Tn-S PAGE REh- -nt,/ . i I REPORT DOCUMENTATION PAGE RE MSTING FORM I REPORT NUMaLA ’ GOVT...standard, deviations, and observation counts of station pressure and sea-level pressure). Data in this report are presented in tabular form , in most cases...DrITOF$ OF tNIS FORM ARE OBSOLETE -" - ,I T ss : II I T;V.2 , 1’ FTE. WEATHER CONDITIONS ". ’ C-.,T A T- STATION STATION NAME YEARS MONTH I. E(-At F

  16. MCNP calculations for container inspection with tagged neutrons

    NASA Astrophysics Data System (ADS)

    Boghen, G.; Donzella, A.; Filippini, V.; Fontana, A.; Lunardon, M.; Moretto, S.; Pesente, S.; Zenoni, A.


    We are developing an innovative tagged neutrons inspection system (TNIS) for cargo containers: the system will allow us to assay the chemical composition of suspect objects, previously identified by a standard X-ray radiography. The operation of the system is extensively being simulated by using the MCNP Monte Carlo code to study different inspection geometries, cargo loads and hidden threat materials. Preliminary simulations evaluating the signal and the signal over background ratio expected as a function of the system parameters are presented. The results for a selection of cases are briefly discussed and demonstrate that the system can operate successfully in different filling conditions.

  17. Lock and Dam 13 Major Rehabilitation Whiteside County, Illinois, Clinton County, Iowa.

    DTIC Science & Technology


    Tnis oermit does not authorize the disposal of crecged material in an Imoortant Resource Area wh-ich has Deen cesionated as such by the illinois...Illinois," approved June 10, 1911, as amenoed. (Illinois Revised Statutes, Cnapter 19, paragraphs 52 et seq.) 2. This oermit does not convey title to, organics 2. Laboratory testing was performed in accordance with EN 1110-2-1906 dated 30 Nov 70, revised 1 Nay 80 and 20 Aug 86. All samples were

  18. Structure and Deformation Characteristics of Rheocast Metals.

    DTIC Science & Technology



  19. Decision Support for Attack Submarine Commanders.

    DTIC Science & Technology



  20. A Strategy for Reforming Avionics Acquisition and Support

    DTIC Science & Technology


    9OS/2-AF S1’ A4-VSM r J. C, Geb ma n. H. L. Shulman ATA 4Qy-r7’-777 SECURITY CLASSIFICATION O. TNIS P&Gg (Whom D & tritedf) REPORT DOCUMENTATION...Range Planning & Doctrine Div, (AF/XOXFP) July 1988 Directorate of Plans, Ofc DCS/Plans & Operations I3. NUMUEROFPAGES Hq USAF, Washington, D . C...avionics subsystems. Results from exploratory applications of the concept to the fire control radars on the F-15 C/ D and the F-16 A/B indicate that the Air

  1. A Laser Trap for Neutral Atoms.

    DTIC Science & Technology


    alexandrite laser operating in DO , 1473 OITIow OFr I NOV ’IS 13 OBSOLETE S/N 0 102- I.F- 0 14- 6601 SECURITY CLASSIFICATION OF TNIS PAGE (WhenOnt...development and characterization of the new alexandrite laser, demonstration of the trap at low densities, and deter- mination of the spatial and...range and the trap depth down by vr). We have used spa- tial filtering to reliably and stabily operate our new cw alexandrite laser as well as argon and

  2. Thermodynamics of High Temperature Materials.

    DTIC Science & Technology


    Department of Commerce 23 -1A , /7 National Bureau of Standards A102 Washington, D.C. 20234 ______________ I I. CONTROLLING OFFICE NAME AND ADDRESS Air...DISTRIBUTION STATEMENT (of this Report) r ~Appro-,’. f’or public re r-: e ; 17. DISTRIBUTION STATEMENT (of the abstract entered in Block 20, It different from...8SOLETE SCRT SEUIYCLASSIFICATION OF TNIS PAGE " e aoEtr AEOST.1-0443 THERMODYNAMICS OF HIGH TEMPERATURE MATERIALS Annual Report for the Period of 1 October

  3. The Toxicity of Nitroguanidine and Photolyzed Nitroguandine to Freshwater Aquatic Organisms

    DTIC Science & Technology


    Paratanytarsus dissimlils), and aquatic worms ( Lumbriculus variegatus ). The. IN) tWS UCLASSIFIED SEURIY4T CLAISIPICAtIOW OF TNIS PAGE (1160 Date U40*4. I. II...2868 0 ( Lumbriculus variegatue ) 1785 0 (1.49 0 a. The high, low, and control NGu concentrations are listed for each test. The top concentration tested...Bailey, H.C. and D.H.W. Liu. 1980. Lumbriculus variegatus , a benthic oligochaete, as a bioassay organism. In: A.L. Buikema and J. Cairns, Jr., eds

  4. The Ecology of the Benthic and Endolithic Communities of a Rocky Reef in the Kelp Beds off Del Monte Beach, Monterey, California.

    DTIC Science & Technology


    RECIPIENT’S CATALOG NUMMER 4. TITLCj~ T.egj max-& ~vRC eocology of the !nthic and %Ser’S hes is,4 .1ndo RLthic ommunities of a lcky eef S EFRIGOG EOTNNE 0 t...1 . CONTRACT OR GRANT mumB90R( s ) 9. PER11FORMING ORGANIZATION NAME ANC ACORESS 10. PROGRAM EL9EMENT. PROJE01CT. TASKC AREA &WORK UNIT MBER’S Naval...COITION OF IMOV goIsSOSL6T7NLSSFE9 ~ ) 41 S /N@10014550 ISECURITY CLASSFICATION OF TNIS PAGE66 IMN Doe ete") UNCLASSIFIED 󈧘. (continued) the level of

  5. Rigid-Flex Printed Circuit Manufacturing process. A Project of the Manufacturing Technology Program.

    DTIC Science & Technology


    002- L -0146601SECURITY CLASSIFICATION OF TNIS PAGE (011ioe Data Bntered) UNCLASSIFIED SUc~hfTY cLAIsaicooricoi OF THIS PACE (IIo "a Mu9.,erva...n I irt I Olut I Av- ’ji L ~ iii1’_ t PREFACE Advances in manufacturing technology are continuing to be made as both new materials and processing...Peel, Laminate Exhibit 10 6 5 4 1 2 3 Cost 5 6 3 4 2 1 L Facility Rating 4 5 2 6 3 1 Indicates Failure/Test Requirements I/ Indicates After Etching T

  6. Technology demonstration of space intravehicular automation and robotics

    NASA Technical Reports Server (NTRS)

    Morris, A. Terry; Barker, L. Keith


    Automation and robotic technologies are being developed and capabilities demonstrated which would increase the productivity of microgravity science and materials processing in the space station laboratory module, especially when the crew is not present. The Automation Technology Branch at NASA Langley has been working in the area of intravehicular automation and robotics (IVAR) to provide a user-friendly development facility, to determine customer requirements for automated laboratory systems, and to improve the quality and efficiency of commercial production and scientific experimentation in space. This paper will describe the IVAR facility and present the results of a demonstration using a simulated protein crystal growth experiment inside a full-scale mockup of the space station laboratory module using a unique seven-degree-of-freedom robot.

  7. Training Maneuver Evaluation for Reduced Order Modeling of Stability & Control Properties Using Computational Fluid Dynamics

    DTIC Science & Technology


    limited additional benefit to the model based on R2 and predicted square error ( PSE ). From experience in this research, the maximum value was seen to be...CLIFT; 117 NORD =5; nord=[NORD NORD NORD]; maxord =5; 53 sig2 =0; auto =1; Iplot =1; ivar =0; bvar =0; 58 maxopt =0; [y,p,ip,crb , pse ,xp,a,ia,psi

  8. Joint Force Quarterly. Number 16, Summer 1997

    DTIC Science & Technology


    Jim Courter and Alvin H. Bernstein 27 Whatever Happened to Defense Industrial Preparedness? by Ivars Gutmanis and John F. Starns 34 The Sisyphus...programs at the Alexis de Tocqueville Institution and Alvin H. Bernstein , founding director of the George C. Marshall European Center for Security...Fuller and Basil Liddell Hart were further off the mark. In fact, much of British failure on the battlefields of 1941–42 in North Africa was due to

  9. Computer Program Development Specification for IDAMST Operational Flight Programs. Addendum 1. Executive Software.

    DTIC Science & Technology


    terminal to receive Zris 7,esscgE. 7/R: rL E or ; 0 v z . ,-c this bit is set zne terminal is t3 s . tnis cit .s not set, the terminal is to receive : usL ...are listed in Table lS -I, and an explanation of each one follows. Those Mode Codes that are not defined here may he used by the system...r0 e w araci~e-xr Ifor hi a temp was W z. py zre value contained in the .i~iparametrr * a~ :’~ carcsot tne actual Pd rc u K:- ’aa e LS . ne

  10. Experimental validation of MCNP simulations for the EURITRACK Tagged Neutron Inspection System

    NASA Astrophysics Data System (ADS)

    Donzella, A.; Bodini, I.; Zenoni, A.; Fontana, A.; Perot, B.; Bernard, S.; Carasco, C.; Mariani, A.; Sudac, D.; Valkovic, V.


    The detection of illicit trafficking such as explosive materials inside large commercial payloads is today an important worldwide problem. Differently from the X- or γ-ray based systems, neutron interrogation allows the elemental composition of inspected materials to be measured. A container interrogation device based on the Tagged Neutron Inspection System (TNIS) has been developed within the EURITRACK (EURopean Illicit TRAfficking Countermeasures Kit) project of the 6th Framework Program of the European Union. A prototype of such system has been integrated at the Ruder Boskovic Institute (IRB) of Zagreb, Croatia, and performance tests have been carried out. A detailed simulation of the IRB experimental set-up has been performed. Comparison of the Monte Carlo predictions with collected experimental data is presented.

  11. Expression of α-gustducin and α-transducin, G proteins coupled with taste receptors, in boar sperm.


    Spinaci, M; Bucci, D; Mazzoni, M; Giaretta, E; Bernardini, C; Vallorani, C; Tamanini, C; Clavenzani, P; Galeati, G


    During the transit in the female genital tract, spermatozoa are exposed to an environment that varies in composition from the vagina to the oviduct. Because G proteins, α-gustducin and α-transducin, are accepted as markers of chemosensitive cells, this study was aimed at assessing whether these proteins are expressed in boar germ cells. Ejaculated sperm extracts were analyzed by Western blot, and indirect immunofluorescence was performed on testis sections, smears of epididymal and ejaculated spermatozoa, sperm cells after in vitro induction of capacitation and acrosome reaction (IVAR), and in sperm cells bound to zona pellucida during IVF. Based on immunoblot results, both G proteins are present in boar sperm. In the testicular tissue sections, α-gustducin and α-transducin positivity was recorded in the germinal cells near the tubular lumen, whereas no positive signal was evident in spermatogonia located in the outer region of the seminiferous tubules. α-Gustducin expression in epididymal and ejaculated spermatozoa was mainly detectable in both the acrosome and the principal piece of the tail, whereas α-transducin was confined to the acrosome and the midpiece. No changes after in vitro induction of capacitation and IVAR were observed, except for the disappearance of acrosomal positivity in reacted spermatozoa. In sperm bound to zona pellucida, the G protein signal was congruent with that observed in IVAR cells. To the best of our knowledge, this is the first description of α-transducin in mammalian sperm and the first description of α-gustducin in boar sperm. Further studies are needed to clarify the possible role of these G proteins in sperm physiology.

  12. SSBRP Communication & Data System Development using the Unified Modeling Language (UML)

    NASA Technical Reports Server (NTRS)

    Windrem, May; Picinich, Lou; Givens, John J. (Technical Monitor)


    The Unified Modeling Language (UML) is the standard method for specifying, visualizing, and documenting the artifacts of an object-oriented system under development. UML is the unification of the object-oriented methods developed by Grady Booch and James Rumbaugh, and of the Use Case Model developed by Ivar Jacobson. This paper discusses the application of UML by the Communications and Data Systems (CDS) team to model the ground control and command of the Space Station Biological Research Project (SSBRP) User Operations Facility (UOF). UML is used to define the context of the system, the logical static structure, the life history of objects, and the interactions among objects.

  13. Physical and dynamical studies of planet-crossing asteroids.

    NASA Astrophysics Data System (ADS)

    Hahn, G.

    This thesis is a summary of the following papers: 1. A data base of observing conditions for Aten-Apollo-Amor objects during the 20th century, 1986. 2. A data base of observing conditions for Aten-Apollo-Amor objects during the 20th century. II. First update (through February 1988), 1988. 3. UBVRI and JHK photometry of the near-Earth asteroid 1862 Apollo, 1983. 4. Physical studies of Apollo-Amor asteroids: UBVRI photometry of 1036 Ganymed and 1627 Ivar, 1988. 5. Physical studies of asteroids XVII: JHK photometry of selected main-belt and near-Earth asteroids, 1988. 6. Asteroids in cometary orbits, 1985. 7. Orbital studies of 1982 YA, 1983 VA and 1984 BC, 1986. 8. Orbital evolution studies of planet-crossing asteroids, 1988.

  14. Observations on the magnitude-frequency distribution of Earth-crossing asteroids

    NASA Technical Reports Server (NTRS)

    Shoemaker, Eugene M.; Shoemaker, Carolyn S.


    During the past decade, discovery of Earth-crossing asteroids has continued at the pace of several per year; the total number of known Earth crossers reached 70 as of September, 1986. The sample of discovered Earth crossers has become large enough to provide a fairly strong statistical basis for calculations of mean probabilities of asteroid collision with the Earth, the Moon, and Venus. It is also now large enough to begin to address the more difficult question of the magnitude-frequency distribution and size distribution of the Earth-crossing asteroids. Absolute V magnitude, H, was derived from reported magnitudes for each Earth crosser on the basis of a standard algorithm that utilizes a physically realistic phase function. The derived values of H range from 12.88 for (1627) Ivar to 21.6 for the Palomar-Leiden object 6344, which is the faintest and smallest asteroid discovered.

  15. Resonances and librations of some Apollo and Amor asteroids with the Earth.

    NASA Technical Reports Server (NTRS)

    Ip, W.-H.; Mehra, R.


    The orbital evolution of the Apollo asteroids 1620 Geographos and 1685 Toro and Amor asteroids 433 Eros, 1221 Amor, and 1627 Ivar are investigated by numerical integration. All these asteroids, with the exception of Geographos, exhibit systematic orbital couplings with the Earth during the time interval studied (1600-2350 A.D.). 1685 Toro is captured into libration once with Venus due to the 13.5 resonance, and once with the Earth due to the 8:5 resonance. Both librations are unstable because of the effect of the 13:8 near commensurability of the Venus-Earth system. 433 Eros exhibits no libration pattern; the regular variation of its orbital period is due to the beat-effect of the 4:7 resonance with the Earth.

  16. Astrometric observations of comets and asteroids and subsequent orbital investigations

    NASA Technical Reports Server (NTRS)

    Mccrosky, R. E.; Marsden, B. G.


    During the past year some 500 observations were made on 66 nights and published on the MPCs (Minor Planet Circulars/Minor Planets and Comets). In addition, a handful of measurements of earlier plates were completed and published. 121 of the observations published referred to comets. Of special importance were observations of comets (P/Giacobini-Zinner and P/Halley) in connection with the NASA ICE and ESA Giotto missions, but a special effort was made to get good coverage of almost all of the observable comets. Observations were also made of (2060) Chiron and of the earth-approaching objects (1627) Ivar, (1866) Sisyphys, (1943) Anteros, (3362) 1984 QA, 1985 JA, PA, TB and WA, and 1986 DA and EB. 46 minor planets were given permanent numbers entirely as a result of the observations.

  17. Lovaas Institute for Early Intervention (LIFE)

    PubMed Central

    Smith, Tristram


    For many years, O. Ivar Lovaas ran a small clinic for children with autism through the department of psychology at UCLA, with undergraduate students providing most of the direct instruction. Throughout the 1970s, the clinic enrolled just a few children in treatment at a time. By the early 1980s, the active caseload had increased to about 5–10 children, and this number rose slowly over the next few years. However, after the publication of Lovaas's landmark study of early intensive behavioral intervention (EIBI) in 1987, followed by an extraordinary firsthand account of one family's experience with the intervention (Maurice, 1993), Lovaas began receiving more requests for treatment in a single day than he had previously received over an entire year. PMID:27999637

  18. Lovaas Institute for Early Intervention (LIFE).


    Smith, Tristram


    For many years, O. Ivar Lovaas ran a small clinic for children with autism through the department of psychology at UCLA, with undergraduate students providing most of the direct instruction. Throughout the 1970s, the clinic enrolled just a few children in treatment at a time. By the early 1980s, the active caseload had increased to about 5-10 children, and this number rose slowly over the next few years. However, after the publication of Lovaas's landmark study of early intensive behavioral intervention (EIBI) in 1987, followed by an extraordinary firsthand account of one family's experience with the intervention (Maurice, 1993), Lovaas began receiving more requests for treatment in a single day than he had previously received over an entire year.

  19. Irradiation of 4''x4'' NaI(Tl) detector by the 14 MeV neutrons.


    Sudac, D; Valkovic, V


    Within the EURopean Illicit TRAfficking Countermeasures Kit (EURITRACK) project, a new Tagged Neutron Inspection System (TNIS) has been developed and installed in the Port of Rijeka in Croatia. The system was based on the examination of sea containers with the 14 MeV neutron beam. During the operation the characteristic gamma rays were produced and measured by several 5''x5''x10'' NaI(Tl) detectors. During this procedure some of the detectors were exposed to an intensive neutron beam radiation. It was necessary to check for possible radiation damage of the NaI(Tl) scintillator during the gamma detector selection phase of the project. The 4''x4'' NaI(Tl) detector was exposed to 14 MeV neutrons for 20 h. From the presented results on energy resolution and activation measurements it could be concluded that there are no significant differences in energy resolution before and after the irradiation by 4.7x10(11) of 14 MeV neutrons. The only problem could be the high level of medium and long term induced activity in the energy region below 2 MeV.

  20. Formation and stabilization of C6- by radiative electron attachment

    NASA Astrophysics Data System (ADS)

    Chandrasekaran, Vijayanand; Prabhakaran, Aneesh; Kafle, Bhim; Rubinstein, Hilel; Heber, Oded; Rappaport, Michael; Toker, Yoni; Zajfman, Daniel


    Radiative electron attachment (REA) plays an important role in forming molecular anions in various astrophysical environments. In this work, we determined the rate coefficient for the formation of C6- by REA based on a detailed balance approach. C6- ions are stored in an electrostatic ion beam trap and are photoexcited above their adiabatic detachment energy (4.18 eV). Due to fast internal conversion and intramolecular vibrational redistribution, photoexcitation leads to the formation of temporary negative ions (TNIs), the same as those one formed by the electron attachment. Absolute vibrational autodetachment and recurrent (or Poincaré) fluorescence (RF) rate coefficients have already been reported [V. Chandrasekaran et al., J. Phys. Chem. Lett. 5, 4078 (2014)]. Knowing the branching ratios of the various competing rate coefficients is decisive to the understanding of the formation probability of anions via REA. The radiative stabilization rate of C6-, shown to be dominated by RF, was determined to be 5 × 104 s-1 at the electron detachment energy, i.e., at least a factor of 100 faster than the stabilization by infrared transitions. The RF is found to very effectively stabilize the TNI formed by electron attachment. Using detailed balance to link the measured delayed detachment rate to the rate of electron attachment, we estimate the REA rate leading to the formation of C6- to be 3 × 10-7 cm3 s-1 at 300 K in agreement with theory (1.7 × 10-7 cm3 s-1 [R. Terzieva and E. Herbst, Int. J. Mass Spectrom. 201, 135 (2000)]). Such a high rate for REA to C6 indicates that REA may play a prominent role in the formation of anions in the interstellar medium.

  1. Spectroscopic and ITC study of the conformational change upon Ca{sup 2+}-binding in TnC C-lobe and TnI peptide complex from Akazara scallop striated muscle

    SciTech Connect

    Yumoto, Fumiaki; Tanaka, Hiroyuki; Nagata, Koji; Miyauchi, Yumiko; Miyakawa, Takuya; Ojima, Takao; Tanokura, Masaru


    Akazara scallop (Chlamys nipponensis akazara) troponin C (TnC) of striated adductor muscle binds only one Ca{sup 2+} ion at the C-terminal EF-hand motif (Site IV), but it works as the Ca{sup 2+}-dependent regulator in adductor muscle contraction. In addition, the scallop troponin (Tn) has been thought to regulate muscle contraction via activating mechanisms that involve the region spanning from the TnC C-lobe (C-lobe) binding site to the inhibitory region of the TnI, and no alternative binding of the TnI C-terminal region to TnC because of no similarity between second TnC-binding regions of vertebrate and the scallop TnIs. To clarify the Ca{sup 2+}-regulatory mechanism of muscle contraction by scallop Tn, we have analyzed the Ca{sup 2+}-binding properties of the complex of TnC C-lobe and TnI peptide, and their interaction using isothermal titration microcalorimetry, nuclear magnetic resonance, circular dichroism, and gel filtration chromatography. The results showed that single Ca{sup 2+}-binding to the Site IV leads to a structural transition not only in Site IV but also Site III through the structural network in the C-lobe of scallop TnC. We therefore assumed that the effect of Ca{sup 2+}-binding must lead to a change in the interaction mode between the C-lobe of TnC and the TnI peptide. The change should be the first event of the transmission of Ca{sup 2+} signal to TnI in Tn ternary complex.

  2. Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm-Tn chain.


    Mijailovich, Srboljub M; Kayser-Herold, Oliver; Li, Xiaochuan; Griffiths, Hugh; Geeves, Michael A


    The regulation of striated muscle contraction involves cooperative interactions between actin filaments, myosin-S1 (S1), tropomyosin (Tm), troponin (Tn), and calcium. These interactions are modeled by treating overlapping tropomyosins as a continuous flexible chain (CFC), weakly confined by electrostatic interactions with actin. The CFC is displaced locally in opposite directions on the actin surface by the binding of either S1 or Troponin I (TnI) to actin. The apparent rate constants for myosin and TnI binding to and detachment from actin are then intrinsically coupled via the CFC model to the presence of neighboring bound S1s and TnIs. Monte Carlo simulations at prescribed values of the CFC stiffness, the CFC's degree of azimuthal confinement, and the angular displacements caused by the bound proteins were able to predict the stopped-flow transients of S1 binding to regulated F-actin. The transients collected over a large range of calcium concentrations could be well described by adjusting a single calcium-dependent parameter, the rate constant of TnI detachment from actin, k(-I). The resulting equilibrium constant K(B) ≡ 1/K(I) varied sigmoidally with the free calcium, increasing from 0.12 at low calcium (pCa >7) to 12 at high calcium (pCa <5.5) with a Hill coefficient of ~2.15. The similarity of the curves for excess-actin and excess-myosin data confirms their allosteric relationship. The spatially explicit calculations confirmed variable sizes for the cooperative units and clustering of bound myosins at low calcium concentrations. Moreover, inclusion of negative cooperativity between myosin units predicted the observed slowing of myosin binding at excess-myosin concentrations.

  3. A Physically Based Correlation of Irradiation-Induced Transition Temperature Shifts for RPV Steels

    SciTech Connect

    Eason, Ernest D.; Odette, George Robert; Nanstad, Randy K; Yamamoto, Takuya


    data. It contains two terms, corresponding to the best-understood radiation damage features, matrix damage and copper-rich precipitates, although the empirical calibration will ensure that all other damage processes that are occurring are also reflected in those terms. Effects of material chemical composition, product form, and radiation exposure are incorporated, such that all effects are supported by findings of statistical significance, physical understanding, or comparison with independent data from controlled experiments, such as the Irradiation Variable (IVAR) Program. In most variable effects, the model is supported by two or three of these different forms of evidence. The key variable trends, such as the neutron fluence dependence and copper-nickel dependence in the new TTS model, are much improved over RG1.99/2 and are well supported by independent data and the current understanding of embrittlement mechanisms. The new model includes the variables copper, nickel, and fluence that are in RG1.99/2, but also includes effects of irradiation temperature, neutron flux, phosphorus, and manganese. The calibrated model is a good fit, with no significant residual error trends in any of the variables used in the model or several additional variables and variable interactions that were investigated. The report includes a chapter summarizing the current understanding of embrittlement mechanisms and one comparing the IVAR database with the TTS model predictions. Generally good agreement is found in that quantitative comparison, providing independent confirmation of the predictive capability of the TTS model. The key new insight in the TTS modeling effort, that flux effects are evident in both low (or no) copper and higher copper materials, is supported by the IVAR data. The slightly simplified version of the TTS model presented in Section 7.3 of this report is recommended for applications.

  4. Physical Characterization of Warm Spitzer-observed Near-Earth Objects

    NASA Technical Reports Server (NTRS)

    Thomas, Cristina A.; Emery, Joshua P.; Trilling, David E.; Delbo, Marco; Hora, Joseph L.; Mueller, Michael


    Near-infrared spectroscopy of Near-Earth Objects (NEOs) connects diagnostic spectral features to specific surface mineralogies. The combination of spectroscopy with albedos and diameters derived from thermal infrared observations can increase the scientific return beyond that of the individual datasets. For instance, some taxonomic classes can be separated into distinct compositional groupings with albedo and different mineralogies with similar albedos can be distinguished with spectroscopy. To that end, we have completed a spectroscopic observing campaign to complement the ExploreNEOs Warm Spitzer program that obtained albedos and diameters of nearly 600 NEOs (Trilling et al., 2010). The spectroscopy campaign included visible and near-infrared observations of ExploreNEOs targets from various observatories. Here we present the results of observations using the low-resolution prism mode (approx. 0.7-2.5 microns) of the SpeX instrument on the NASA Infrared Telescope Facility (IRTF). We also include near-infrared observations of Explore-NEOs targets from the MIT-UH-IRTF Joint Campaign for Spectral Reconnaissance. Our dataset includes near-infrared spectra of 187 ExploreNEOs targets (125 observations of 92 objects from our survey and 213 observations of 154 objects from the MIT survey). We identify a taxonomic class for each spectrum and use band parameter analysis to investigate the mineralogies for the S-, Q-, and V-complex objects. Our analysis suggests that for spectra that contain near-infrared data but lack the visible wavelength region, the Bus-DeMeo system misidentifies some S-types as Q-types. We find no correlation between spectral band parameters and ExploreNEOs albedos and diameters. We investigate the correlations of phase angle with band area ratio and near-infrared spectral slope. We find slightly negative Band Area Ratio (BAR) correlations with phase angle for Eros and Ivar, but a positive BAR correlation with phase angle for Ganymed.The results of our

  5. Physical characterization of Warm Spitzer-observed near-Earth objects

    NASA Astrophysics Data System (ADS)

    Thomas, Cristina A.; Emery, Joshua P.; Trilling, David E.; Delbó, Marco; Hora, Joseph L.; Mueller, Michael


    Near-infrared spectroscopy of Near-Earth Objects (NEOs) connects diagnostic spectral features to specific surface mineralogies. The combination of spectroscopy with albedos and diameters derived from thermal infrared observations can increase the scientific return beyond that of the individual datasets. For instance, some taxonomic classes can be separated into distinct compositional groupings with albedo and different mineralogies with similar albedos can be distinguished with spectroscopy. To that end, we have completed a spectroscopic observing campaign to complement the ExploreNEOs Warm Spitzer program that obtained albedos and diameters of nearly 600 NEOs (Trilling, D.E. et al. [2010]. Astron. J. 140, 770-784. The spectroscopy campaign included visible and near-infrared observations of ExploreNEOs targets from various observatories. Here we present the results of observations using the low-resolution prism mode (˜0.7-2.5 μm) of the SpeX instrument on the NASA Infrared Telescope Facility (IRTF). We also include near-infrared observations of ExploreNEOs targets from the MIT-UH-IRTF Joint Campaign for Spectral Reconnaissance. Our dataset includes near-infrared spectra of 187 ExploreNEOs targets (125 observations of 92 objects from our survey and 213 observations of 154 objects from the MIT survey). We identify a taxonomic class for each spectrum and use band parameter analysis to investigate the mineralogies for the S-, Q-, and V-complex objects. Our analysis suggests that for spectra that contain near-infrared data but lack the visible wavelength region, the Bus-DeMeo system misidentifies some S-types as Q-types. We find no correlation between spectral band parameters and ExploreNEOs albedos and diameters. We investigate the correlations of phase angle with Band Area Ratio and near-infrared spectral slope. We find slightly negative Band Area Ratio (BAR) correlations with phase angle for Eros and Ivar, but a

  6. Orbit-orbit resonances in the solar system - Varieties and similarities

    NASA Technical Reports Server (NTRS)

    Greenberg, R.


    Descriptions of various orbit-orbit resonance mechanisms in the solar system are brought together in such a manner that the physical processes underlying the traditional mathematical presentations are apparent. A simple qualitative model based on the resonance between Saturn's satellites Titan and Hyperion is presented, the same resonance is analyzed quantitatively, and the small-eccentricity mechanism is examined. The following resonances are investigated in detail: Enceladus-Dione, Mimas-Tethys, Neptune-Pluto, and Rhea-Titan (secular resonance). Coupled librations of several asteroids near mean motions commensurable with Jupiter's are modeled, the Laplace relation involving Io, Europa, and Ganymede is studied, and the 1:1 resonance between the Trojan asteroids and Jupiter is discussed. Some higher-order commensurabilities involving asteroids are considered, including the 3:1 resonance between Alinda and Jupiter, the 13:5 resonance of Toro with Venus, the 8:5 resonance of Toro with earth, and the 11:28 resonance of Ivar with earth.

  7. Radar investigation of asteroids and planetary satellites

    NASA Technical Reports Server (NTRS)

    Ostro, Steven J.


    The aim is to make radar reconnaissance of near-Earth asteroids, mainbelt ateroids, the Galilean satellites, the Martian satellites, and the largest Saturnian satellites, using the Arecibo 13-cm and the Goldstone 3.5-cm systems. Measurements of echo strength, polarization, and delay/Doppler distribution of echo power provide information about dimensions, spin vector, large-scale topography, cm-to-m-scale morphology, and surface bulk density. The observations also yield refined estimates of target orbital elements. Radar signatures were measured for 31 mainbelt asteroids and 16 near-Earth asteroids since this task began eight years ago. The dispersion in asteroid radar albedoes and circular polarization ratios is extreme, revealing huge differences in surface morphologies, bulk densities, and metal concentration. For the most part, correction between radar signature and VIS/IR class is not high. Many near-Earth asteroids have extremely irregular, nonconvex shapes, but some have polar silhouettes that appear only slightly noncircular. The signatures of 1627 Ivar, 1986 DA, and the approximately 180-km mainbelt asteroid 216 Kleopatra suggest bifurcated shapes. Observational milestones during 1987 and 1988 are noted.

  8. From X-Rays to MRI: Physics in GE

    NASA Astrophysics Data System (ADS)

    Schmitt, Roland W.


    The GE Research Laboratory, founded in 1900, became the first laboratory of scientific research in U.S. industry. William Coolidge, a physicist, joined the laboratory in 1905 and produced two advances of immense importance. The first, ductile tungsten, is still the heart of every incandescent light bulb. The second, the "Coolidge" X-Ray tube, remains an essential tool of modern medicine. In the process, Coolidge explored two main approaches of physics in industry. One addresses a commercial problem or opportunity (better light bulbs) and finds interesting physics. The other explores interesting physics (X-rays) and creates a commercial opportunity. This paper addresses the mix of these approaches during GE's years as an "electric" (and therefore physics-based) company. Episodes include the following: the work of Irving Langmuir (1932 Nobel laureate in chemistry, but as much physicist as chemist); the post-World War II "golden age of industrial physics" when the endless frontier offered opportunities from nuclear power to diamond making to superconductivity; the Nobel-prize winning work of Ivar Giaever; and interdisciplinary efforts that enabled GE to become a world business leader in two medical diagnostic technologies it did not invent: computed tomography and magnetic resonance imaging. I will speculate on whether this mix of problem-driven and opportunity-driven effort is as relevant to the 21st century as it was to the 20th.

  9. Planet-crossing asteroids: Interrelationships within the solar system

    NASA Technical Reports Server (NTRS)

    Mcfadden, L. A.; Ahearn, M. F.


    Near-infrared reflectance spectra 0.6 to 2.5 micrometer were acquired of asteroids 1627 Ivar (Amor), 43 Ariadne, 335 Roberta, 386 Siegena and 695 Bella (3:1 Kirkwood Gap) with the IRTF, Mauna Kea. CCD spectra 0.5-1.0 micrometer were acquired of 1866 Sisyphus (Apollo), 17 Thetis, 695 Bella, 797 Montana, and 877 Walkure (3:1 Kirkwood Gap) using facilities at Cerro Tololo Inter-American Observatory. An upper limit on the production rate of CN in asteroid 3200 Phaeton of < 4 x 10 to the 23rd power sec was determined based on photometric measurements at 3871A using facilities at Lowell Observatory. This value is in the range of the lowest production rate measured for a comet, however, it does not constitute a positive detection of CN in this asteroid. A first attempt of look for companion objects or evidence of dust debris associated with this asteroid was made with a CCD camera. Whereas the search extended to 19th magnitude (corresponding to 150m and 330m for albedos of 0.15 and 0.03 respectively), a look close enough to the asteroid was not attained to definitively eliminate the presence of coorbiting dust debris.

  10. Lowell Observatory Near-Earth Asteroid Photometric Survey (NEAPS) - 2008 May through 2008 December

    NASA Astrophysics Data System (ADS)

    Skiff, Brian A.; Bowell, Edward; Koehn, Bruce W.; Sanborn, Jason J.; McLelland, Kyle P.; Warner, Brian D.


    We report the results of the Lowell Observatory Near- Earth Asteroid Photometric Survey (NEAPS) for the interval 2008-05-01 to 2008-12-31. We obtained photometric data for 46 asteroids including 1036 Ganymed, 1620 Geographos, 1627 Ivar, 1865 Cerberus, 1980 Tezcatlipoca, 2363 Cebriones, 4179 Toutatis, 4257 Ubasti, 5332 Davidaguilar, 7358 Oze, (8567) 1996 HW1, (16960) 1998 QS52, (39572) 1993 DQ1, (53430) 1999 TY16, (66146) 1998 TU3, (85774) 1998 UT18, (87684) 2000 SY2, (136849) 1998 CS1, (137032) 1998 UO1, (137805) 1999 YK5, (138852) 2000 WN10, (142348) 2002 RX211, (144901) 2004 WG1, (162900) 2001 HG31, (163000) 2001 SW169, (164400) 2005 GN59, (171576) 1999 VP11, (185851) 2000 DP107, (185854) 2000 EU106, (189700) 2001 TA45, (190135) 2005 QE30, (190491) 2000 FJ10, (231134) 2005 TU45, (248818) 2006 SZ217, (257744) 2000 AD205, 1998 SJ70, 2004 XK3, 2006 VB14, 2007 VQ4, 2008 EV5, 2008 QS11, 2008 SA, 2008 SE, 2008 SQ1, 2008 SR1, and 2008 US4.

  11. Orbital evolution studies of planet-crossing asteroids.

    NASA Astrophysics Data System (ADS)

    Hahn, Gerhard; Lagerkvist, Claes-Ingvar


    Numerical integrations of 26 orbits of planet-crossing astetoids of Apollo-Amor type have been performed, in a solar system model including the perturbations by the planets from Venus to Neptune. The 15:th order RADAU integrator (Everhart, 1985) has been used. Orbits for the asteroids 433 Eros, 887 Alinda, 1036 Ganymed, 1221 Amor, 1580 Betulia, 1627 Ivar, 1685 Toro, 1862 Apollo, 1863 Antinous, 1864 Daedalus, 1865 Cerberus, 1915 Quetzalcoatl and 1916 Boreas have been integrated over 100 000 years forward in time and for 1866 Sisyphus, 2102 Tantalus, 2201 Oljato, 2329 Orthos, 3360 1981 VA, 3552 1983 SA, 1981 EJ30, 1985 PA, 1985 WA, 1986 DA 1986 JK and 1986 RA a period of about 33 000 years has been covered. The orbital evolutions of these asteroids are discussed. This work is part of a larger study of the long-term orbital evolution of planet-crossing asteroids and will be continued within the project SPACEGUARD (Milani et al., 1987).

  12. The Contribution of Soil Moisture Information to Forecast Skill: Two Studies

    NASA Technical Reports Server (NTRS)

    Koster, Randal


    This talk briefly describes two recent studies on the impact of soil moisture information on hydrological and meteorological prediction. While the studies utilize soil moisture derived from the integration of large-scale land surface models with observations-based meteorological data, the results directly illustrate the potential usefulness of satellite-derived soil moisture information (e.g., from SMOS and SMAP) for applications in prediction. The first study, the GEWEX- and ClIVAR-sponsored GLACE-2 project, quantifies the contribution of realistic soil moisture initialization to skill in subseasonal forecasts of precipitation and air temperature (out to two months). The multi-model study shows that soil moisture information does indeed contribute skill to the forecasts, particularly for air temperature, and particularly when the initial local soil moisture anomaly is large. Furthermore, the skill contributions tend to be larger where the soil moisture initialization is more accurate, as measured by the density of the observational network contributing to the initialization. The second study focuses on streamflow prediction. The relative contributions of snow and soil moisture initialization to skill in streamflow prediction at seasonal lead, in the absence of knowledge of meteorological anomalies during the forecast period, were quantified with several land surface models using uniquely designed numerical experiments and naturalized streamflow data covering mUltiple decades over the western United States. In several basins, accurate soil moisture initialization is found to contribute significant levels of predictive skill. Depending on the date of forecast issue, the contributions can be significant out to leads of six months. Both studies suggest that improvements in soil moisture initialization would lead to increases in predictive skill. The relevance of SMOS and SMAP satellite-based soil moisture information to prediction are discussed in the context of these

  13. Environmental problems and geological implications derived from evaporite dissolution in the Barbastro salt anticline (NE Spain)

    NASA Astrophysics Data System (ADS)

    Lucha, P.; Gutiérrez, F.; Guerrero, J.


    The halite-bearing Barbastro Formation crops out in the core of the Barbastro Anticline (Ebro Tertiary Basin). This anticline is traversed perpendicularly by some of the most important Pyrenean drainages such as the Cinca and Noguera-Ribagorzana Rivers. The terrace sequences of these fluvial systems have been used as markers to identify and assess dissolution-induced subsidence and salt tectonics. In the limbs of the anticline, terrace deposits underlain by detrital bedrock do not show any evidence of deformation and have a consistent thickness of less than 10 m. The deposits of certain terrace levels of the Noguera-Ribagorzana River and its tributary, the Lo Reguer Creek, are locally thickened filling basins generated by dissolution-induced synsedimentary subsidence up to several kilometers long and more than 100 m deep. Conversely, terraces of the Cinca River do not show anomalously high thicknesses, but local uplifts related to differential upward flow of the halite-bearing bedrock. Locally, a minimum uplift rate of 0.3 mm/year has been estimated from a 64-ka terrace tilted away from the valley. The subsidence hazards occur chiefly in areas where the ground receives artificial water recharge. Serviceability of some canals has been notoriously affected by evaporite karstification. The problem has been mitigated to acceptable levels by grouting. Numerous buildings of Ivars de Noguera are severely damaged by dissolution subsidence, and possibly, by hydrocompaction of gypsiferous silts. The pipe network has been replaced to ameliorate the subsidence risk. In the Cinca River valley, cavities with a total volume of about 180,500 m3 have been created by solution mining at depths greater than 500 m. No investigation methods are applied in the brine field to monitor the distribution and evolution of artificial voids. Substantial increase in salinity of the Cinca River is another evidence of subjacent evaporite dissolution.

  14. A study of the 21 March 2012 tornadic quasi linear convective system in Catalonia

    NASA Astrophysics Data System (ADS)

    Bech, Joan; Arús, Joan; Castán, Salvador; Pineda, Nicolau; Rigo, Tomeu; Montanyà, Joan; van der Velde, Oscar


    This study presents a description of a quasi linear convective system that took place in Catalonia (NE Spain) on 21 March 2012 producing heavy rainfall, moderate lightning activity and a weak tornado in the village of Ivars d'Urgell around 19 UTC after local sunset. A post-event survey indicated EF0 and EF1 damage in houses of the village - roofs and ceilings, broken windows, fences and walls and trees knocked down - along a track approximately 4 km long and about 20 m wide. Doppler radar observations show that the parent thunderstorm that spawned the tornado was one of a series that developed along a convective line that moved from S to N, initiating convective activity in terms of precipitation and lightning in the Mediterranean Sea and moving inland in S Catalonia (Tarragona and Salou coastal areas, producing local flash floods). Convective activity remained several hours with series of thunderstorms developing along the same paths. The synoptic situation was dominated by a high pressure ridge extending from northern Africa to central Europe, with a closed maximum sea level pressure area around 1036 hPa over northern France, southern Germany and Austria. On the other hand a relative low pressure area seen on 850 hPa and upper levels was present over the Iberian Peninsula, favouring a southern maritime flow from the Mediterranean between the forward part of the low pressure area and the high pressure system which blocked the advance of the low to the east. In the study we examine both the synoptic environment and storm scale observations with Doppler radar and total lightning data (cloud to ground and intracloud flashes) that lead to this cool-season severe convective event which is remarkable given the fact that, unlike in this case, most reported tornadoes in the region occur during the warm season (with peaks in August and September) and during daylight hours (6 to 18 UTC).

  15. The Arctic Mars Analogue Svalbard Expedition 2010. (Invited)

    NASA Astrophysics Data System (ADS)

    Steele, A.; Benning, L. G.; Fogel, M. L.; Amundsen, H.; Schmitz, N.; Amase 2010 Team


    The Arctic Mars Analogue Svalbard Expeditions (AMASE) 2010 was the latest of a series of expeditions that are NASA ASTEP and ESA funded and have as their primary goals 1) testing portable instruments for their robustness as field instruments for life detection, 2) assessing Mars analogue environments for abiosignatures and biosignatures, 3) refining protocols for contamination reduction, 4) defining a minimal instrument suite for Astrobiology science on Mars and 5) sample acquisition, collection and caching of suitable samples by rover platforms containing sample acquisition hardware: first Cliffbot, then Athena. As well as testing ESA instrumentation for the ExoMars mission and NASA instruments for Mars Science Laboratory, the goals and technologies used during this 2010 campaign are very similar to that proposed by the current MEPAG MAX-C mission concept and therefore set the stage for future sample return missions. As such the field-tested technologies, procedures and protocols can be used to address specific science objectives proposed for the 2018 Mars mission opportunity. As NASA and ESA enter a new era of collaboration, AMASE has provided and will continue to provide, a test bed for both current in-situ robotic missions and Mars Sample Return mission architectures. AMASE has proved to be a unique platform to build understanding and collaboration amongst scientists and engineers from Europe and the USA. AMASE 2010 team (other than those mentioned above): Ivar Midtkandal, Kjell Ove Storvik, Garret Huntress, Verena Starke, Pan Conrad, Francis McCubbin, Tor Viscor, Antonio Sensano, Laureline Josset, Jean-Luc Josset, Mihaela Glamoclija, Steve Squyres, Inge Loes Ten Kate, Kyong Hou, Jen Stern, Amy McAdam, Dave Blake, Dick Morris, Claire Cousins, Arnold Bauer, Carole Phillippon, Eckhard Steinmetz, Dave Potts, Dominique Tobler, Guillermo Lopez.

  16. Balloon Angioplasty – The Legacy of Andreas Grüntzig, M.D. (1939–1985)

    PubMed Central

    Barton, Matthias; Grüntzig, Johannes; Husmann, Marc; Rösch, Josef


    In 1974, at the Medical Policlinic of the University of Zürich, German-born physician-scientist Andreas Grüntzig (1939–1985) for the first time applied a balloon-tipped catheter to re-open a severely stenosed femoral artery, a procedure, which he initially called “percutaneous transluminal dilatation”. Balloon angioplasty as a therapy of atherosclerotic vascular disease, for which Grüntzig and Charles T. Dotter (1920–1985) received a nomination for the Nobel Prize in Physiology or Medicine in 1978, became one of the most successful examples of translational medicine in the twentieth century. Known today as percutaneous transluminal angioplasty (PTA) in peripheral arteries or percutaneous transluminal coronary angioplasty (PTCA) or percutaneous coronary intervention (PCI) in coronary arteries, balloon angioplasty has become the method of choice to treat patients with acute myocardial infarction or occluded leg arteries. On the occasion of the 40th anniversary of balloon angioplasty, we summarize Grüntzig’s life and career in Germany, Switzerland, and the United States and also review the developments in vascular medicine from the 1890s to the 1980s, including Dotter’s first accidental angioplasty in 1963. The work of pioneers of catheterization, including Pedro L. Fariñas in Cuba, André F. Cournand in France, Werner Forssmann, Werner Porstmann and Eberhard Zeitler in Germany, António Egas Moniz and Reynaldo dos Santos in Portugal, Sven-Ivar Seldinger in Sweden, and Barney Brooks, Thomas J. Fogarty, Melvin P. Judkins, Richard K. Myler, Dickinson W. Richards, and F. Mason Sones in the United States, is discussed. We also present quotes by Grüntzig and excerpts from his unfinished autobiography, statements of Grüntzig’s former colleagues and contemporary witnesses, and have included hitherto unpublished historic photographs and links to archive recordings and historic materials. This year, on June 25, 2014, Andreas Grüntzig would have celebrated

  17. Synchrotron X-ray Scattering from Self-organized Soft Nanostructures in Clays

    NASA Astrophysics Data System (ADS)

    Fossum, J. O.


    . Gog, C. Venkataraman, Observations of orientational ordering in aqueous suspensions of a nano-layered silicate, ENERGY The International Journal 30, 873 (2005). 2. D. M. Fonseca, Y. Méheust, J. O. Fossum, K. D. Knudsen, K. J. Måløy and K. P. S. Parmar, Phase behavior of platelet-shaped nanosilicate colloids in saline solutions: A small-angle X-ray scattering study J. Appl. Cryst. 40 292 (2007) 3. E. N. de Azevedo, M. Engelsberg, J. O. Fossum, R. E. de Souza, Anisotropic water diffusion in nematic self-assemblies of clay nano-platelets suspended in water, Langmuir 23, 5100 (2007) 4. Nils Ivar Ringdal, Master thesis, Department of Physics, NTNU (2008) 5. J.O. Fossum, Y. Meheust, K.P.S. Parmar, K.D. Knudsen, K.J. Maloy, D.d.M. Fonseca, Intercalation-enhanced electric polarization and chain formation of nano-layered particles, Europhys. Lett., 74, 438 (2006), and in the Scientific Highlights 2006 of the European Synchrotron Radiation Facility - ESRF (2007) 6. K.P.S. Parmar, Y. Meheust, B. Schelderupsen and J.O. Fossum, Electrorheological suspensions of laponite in oil: rheometry studies, Langmuir 24,1814 (2008) 7. F. Bergaya, B. K. G. Theng, and G. Lagaly, editors. Handbook of Clay Science. Elsevier (2006)