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Sample records for iz stran ljubvi

  1. Near-contact Binaries IZ Monocerotis and AR Draconis

    NASA Astrophysics Data System (ADS)

    Yang, Yuan-Gui; Dai, Hai-Feng; Zhou, Zheng; Li, Qun

    2016-05-01

    We present multi-color photometric observations for two neglected near-contact binaries, IZ Mon (P=0\\_\\_AMP\\_\\_fd;77980) and AR Dra (P=0\\_\\_AMP\\_\\_fd;67584). By the aid of the updated W-D analysis code, the photometric solutions were deduced from the multi-color light curves (LCs). IZ Mon is a semi-detached binary with a mass ratio of q=0.388(+/- 0.002), while AR Dra is a detached star with a mass ratio of q=0.652(+/- 0.002). The asymmetric LCs of IZ Mon were modeled by a hot spot on the secondary’s surface, which may be attributed to mass transfer from the primary. Based on all collected eclipse times for two systems, we constructed their timing residual curves. The orbital period for IZ Mon may be continuously decreasing at a rate of {dP}/{dt}=-2.06(+/- 0.04) {days} {{yr}}-1, which may result from mass and angular momentum loss from the central system. For AR Dra, there exists a cyclic variation with a period of {P}3=104.9(+/- 2.9) {yr} due to light-time orbit effect via the presence of the third body, whose mass is more than 0.28(+/- 0.02) {M}⊙ . Finally, two near-contact binaries, IZ Mon and AR Dra, will evolve into contact binaries.

  2. Radio evolution of supernova SN 2008iz in M 82

    NASA Astrophysics Data System (ADS)

    Kimani, N.; Sendlinger, K.; Brunthaler, A.; Menten, K. M.; Martí-Vidal, I.; Henkel, C.; Falcke, H.; Muxlow, T. W. B.; Beswick, R. J.; Bower, G. C.

    2016-08-01

    We report on multi-frequency Very Large Array (VLA) and Very Long Baseline Interferometry (VLBI) radio observations for a monitoring campaign of supernova SN 2008iz in the nearby irregular galaxy M 82. We fit two models to the data, a simple time power-law, S ∝ tβ, and a simplified Weiler model, yielding decline indices of β = -1.22 ± 0.07 (days 100-1500) and -1.41 ± 0.02 (days 76-2167), respectively. The late-time radio light-curve evolution shows flux-density flares at ~970 and ~1400 days that are a factor of ~2 and ~4 higher than the expected flux, respectively. The later flare, except for being brighter, does not show signs of decline at least from results examined so far (2014 January 23; day 2167). We derive the spectral index, α, S ∝ να for frequencies 1.4 to 43 GHz for SN 2008iz during the period from ~430 to 2167 days after the supernova explosion. The value of α shows no signs of evolution and remains steep ≈-1 throughout the period, unlike that of SN 1993J, which started flattening at ~day 970. From the 4.8 and 8.4 GHz VLBI images, the supernova expansion is seen to start with a shell-like structure that becomes increasingly more asymmetric, then breaks up in the later epochs, with bright structures dominating the southern part of the ring. This structural evolution differs significantly from SN 1993J, which remains circularly symmetric over 4000 days after the explosion. The VLBI 4.8 and 8.4 GHz images are used to derive a deceleration index, m, for SN 2008iz, of 0.86 ± 0.02, and the average expansion velocity between days 73 and 1400 as (12.1 ± 0.2) × 103 km s-1. From the energy equipartition between magnetic field and particles, we estimate the minimum total energy in relativistic particles and the magnetic fields during the supernova expansion and also find the magnetic field amplification factor for SN 2008iz to be in the range of 55-400. The VLBI images (FITS files) are only available at the CDS via anonymous ftp to http

  3. VizieR Online Data Catalog: BVR photometry of IZ Mon and AR Dra (Yang+, 2016)

    NASA Astrophysics Data System (ADS)

    Yang, Y.-G.; Dai, H.-F.; Zhou, Z.; Li, Q.

    2016-07-01

    CCD Photometry for IZ Mon and AR Dra, was acquired using the 60cm telescope and the 85cm telescope at the Xinglong station (XLs) of National Astronomical Observatories of China (NAOC). Two telescopes are equipped with the standard Johnson-Cousins UBVRcIc. filters. We then obtained the individual observations as heliocentric Julian dates and differential magnitude, which are listed in Table1. The complete light curves for IZ Mon were obtained on 2009 January 20, 22, 24, 25, and 26, and March 1, using the 85cm telescope. The exposure times are fixed to be 20, 15, and 15s for BVR bands, respectively. A total of 961, 960, and 959 effective images in BVR bands are obtained. Another primary eclipse for IZ Mon was monitored on 2011 January 17. AR Dra was observed on 2009 February 20, 25, 26, and 27, with the 65cm telescope. The typical exposure times are 50, 40 and 40s for BVR bands, which depend on the condition of weather. In total, we obtained 733, 728 and 356 images in B, V and R bands, respectively. (6 data files).

  4. Anharmonic Vibrational Analysis of the Infrared and Raman Gas-Phase Spectra of s-trans- and s-gauche-1,3-Butadiene.

    PubMed

    Krasnoshchekov, Sergey V; Craig, Norman C; Boopalachandran, Praveenkumar; Laane, Jaan; Stepanov, Nikolay F

    2015-10-29

    A quantum-mechanical (hybrid MP2/cc-pVTZ and CCSD(T)/cc-pVTZ) full quartic potential energy surface (PES) in rectilinear normal coordinates and the second-order operator canonical Van Vleck perturbation theory (CVPT2) are employed to predict the anharmonic vibrational spectra of s-trans- and s-gauche-butadiene (BDE). These predictions are used to interpret their infrared and Raman scattering spectra. New high-temperature Raman spectra in the gas phase are presented in support of assignments for the gauche conformer. The CVPT2 solution is based on a PES and electro-optical properties (EOP; dipole moment and polarizability) expanded in Taylor series. Higher terms than those routinely available from Gaussian09 software were calculated by numerical differentiation of quadratic force fields and EOP using the MP2/cc-pVTZ model. The integer coefficients of the polyad quantum numbers were derived for both conformers of BDE. Replacement of harmonic frequencies by their counterparts from the CCSD(T)/cc-pVTZ model significantly improved the agreement with experimental data for s-trans-BDE (root-mean-square deviation ≈ 5.5 cm(-1)). The accuracy in predicting the rather well-studied spectrum of fundamentals of s-trans-BDE assures good predictions of the spectrum of s-gauche-BDE. A nearly complete assignment of fundamentals was obtained for the gauche conformer. Many nonfundamental transitions of the BDE conformers were interpreted as well. The predictions of multiple Fermi resonances in the complex CH-stretching region correlate well with experiment. It is shown that solving a vibrational anharmonic problem through a numerical-analytic implementation of CVPT2 is a straightforward and computationally advantageous approach for medium-size molecules in comparison with the standard second-order vibrational perturbation theory (VPT2) based on analytic expressions.

  5. Copolymerization of Propylene and Polar Monomers Using Pd/IzQO Catalysts.

    PubMed

    Nakano, Ryo; Nozaki, Kyoko

    2015-09-02

    Palladium catalysts bearing imidazo[1,5-a]quinolin-9-olate-1-ylidene (IzQO) ligands polymerize α-olefins while incorporating polar monomers. The steric environment provided by N-heterocyclic-carbene (NHC) enables regioselective insertion of α-olefins and polar monomers, yielding polypropylene, propylene/allyl carboxylate copolymers, and propylene/methyl acrylate copolymer. Known polymerization catalysts bearing NHC-based ligands decompose rapidly, whereas the present catalyst is durable because of structural confinement, wherein the NHC-plane is coplanar to the metal square plane. The present catalyst system enables facile access to a new class of functionalized polyolefins and helps conceive a new fundamental principle for designing NHC-based ligands.

  6. Quantitative Infrared Absorption Spectra and Vibrational Assignments of Crotonaldehyde and Methyl Vinyl Ketone Using Gas-Phase Mid-Infrared, Far-Infrared, and Liquid Raman Spectra: s-cis vs s-trans Composition Confirmed via Temperature Studies and ab Initio Methods.

    PubMed

    Lindenmaier, Rodica; Williams, Stephen D; Sams, Robert L; Johnson, Timothy J

    2017-02-16

    Methyl vinyl ketone (MVK) and crotonaldehyde are chemical isomers; both are also important species in tropospheric chemistry. We report quantitative vapor-phase infrared spectra of crotonaldehyde and MVK vapors over the 540-6500 cm(-1) range. Vibrational assignments of all fundamental modes are made for both molecules on the basis of far- and mid-infrared vapor-phase spectra, liquid Raman spectra, along with density functional theory and ab initio MP2 and high energy-accuracy compound theoretical models (W1BD). Theoretical results indicate that at room temperature the crotonaldehyde equilibrium mixture is approximately 97% s-trans and only 3% s-cis conformer. Nearly all observed bands are thus associated with the s-trans conformer, but a few appear to be uniquely associated with the s-cis conformer, notably ν16(c) at 730.90 cm(-1), which displays a substantial intensity increase with temperature (70% upon going from 5 to 50 (o) C). The intensity of the corresponding mode of the s-trans conformer decreases with temperature. Under the same conditions, the MVK equilibrium mixture is approximately 69% s-trans conformer and 31% s-cis. W1BD calculations indicate that for MVK this is one of those (rare) cases where there are comparable populations of both conformers, approximately doubling the number of observed bands and exacerbating the vibrational assignments. We uniquely assign the bands associated with both the MVK s-cis conformer as well as those of the s-trans, thus completing the vibrational analyses of both conformers from the same set of experimental spectra. Integrated band intensities are reported for both molecules along with global warming potential values. Using the quantitative IR data, potential bands for atmospheric monitoring are also discussed.

  7. 76 FR 73760 - In the Matter of the Designation of Imad Fa'iz Mughniyah also Known as Imad Fayiz Mughniyah as a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE In the Matter of the Designation of Imad Fa'iz Mughniyah also Known as Imad Fayiz Mughniyah as a Specially Designated Global Terrorist Pursuant to Section 1(b) of Executive Order 13224, as Amended In accordance with section 1(b) of Executive Order 13224,...

  8. Response of lake water quality to wastewater inputs from land-based fish farm located on Yuvarlakçay Creek in Köyceğiz-Dalyan Specially Protected Area, Turkey.

    PubMed

    Taşeli, B K

    2009-10-01

    Köyceğiz Lake is located in the south-western part of Turkey. The area between the Köyceğiz Lake and the Mediterranean Sea is covered with four small lakes and several canals. The surroundings of the lake, canals and forests have a great potential as a reproduction areas for Mediterranean Sea turtles (Caretta caretta) and sheltering place for various animals. In the vicinity of this system there are agricultural areas and small settlements. In this region the most important economic activities are tourism and fisheries. However, the lake is currently threatened by pollution because of (1) non-point source pollution (agriculture); (2) point sources (land-based fish farms); (3) inefficient sewerage systems; (4) uncontrolled soil erosion in its drainage basin; (5) inappropriate flood control measures; and (6) channel traffic. This study evaluates the influence of its influent creeks namely Namnam and Yuvarlakçay Creek on the water quality of Köyceğiz Lake, mainly because the creeks are believed to be responsible for the major pollutant load reaching the lake. Accordingly, this study demonstrates (1) change in the water quality of Köyceğiz Lake from 2006 to 2007; (2) the water quality classification of the major influent creeks feeding Köyceğiz Lake; and (3) how land-based fish farm influences Yuvarlakçay Creek water quality in a Köyceğiz-Dalyan Specially Protected Area.

  9. [Clinical and microbiological study of mycetomas at the Muñiz hospital of Buenos Aires between 1989 and 2004].

    PubMed

    Negroni, R; López Daneri, G; Arechavala, A; Bianchi, M H; Robles, A M

    2006-01-01

    This work presents clinical, microbiological and outcome data collected from 76 patients with mycetomas at the Muñiz Hospital from 1989 to 2004. Forty-nine patients were male and 27 female; the mean age was 43.4 years. The majority of the patients acquired the infection in Argentina: the most affected provinces were Santiago del Estero with 31 cases, and Chaco with 11; 8 cases came from other countries (Bolivia 6 and Paraguay 2). The mean evolution of the disease was 9.2 years. The most frequently observed sites were: feet 63 cases, ankles 3, and knees 2. Forty-eight patients had bone lesions and 5, adenomegalies. The following etiological agents were identified: Madurella grisea 29 cases, Actinomadura madurae 26, Scedosporium apiospermum 5, Nocardia brasiliensis 5, Acremonium spp. 4 (Acremonium falciforme 2, Acremonium kiliense 1, Acremonium recifei 1), Madurella mycetomatis 3, Fusarium solani 2, Nocardia asteroides 1 and Streptomyces somaliensis 1. The main drugs used in the treatments were ketoconazole and itraconazole for maduromycotic mycetomas, and cotrimoxazole associated with ciprofloxacin or amikacin for actinomycetic mycetoma. Six patients had to undergo amputation, 25 cases achieved complete clinical remission and 34 showed remarkable improvement.

  10. Earthquake-induced soft-sediment deformations and seismically amplified erosion rates recorded in varved sediments of Köyceğiz Lake (SW Turkey)

    NASA Astrophysics Data System (ADS)

    Avşar, Ulaş; Jónsson, Sigurjón; Avşar, Özgür; Schmidt, Sabine

    2016-06-01

    Earthquake-triggered landslides amplify erosion rates in catchments, i.e., catchment response (CR) to seismic shocks. In addition to historical eyewitness accounts of muddy rivers implying CRs after large earthquakes, several studies have quantitatively reported increased sediment concentrations in rivers after earthquakes. However, only a few paleolimnological studies could detect CRs within lacustrine sedimentary sequences as siliciclastic-enriched intercalations within background sedimentation. Since siliciclastic-enriched intercalations can easily be of nonseismic origin, their temporal correlation with nearby earthquakes is crucial to assign a seismic triggering mechanism. In most cases, either uncertainties in dating methods or the lack of recent seismic activity has prevented reliable temporal correlations, making the seismic origin of observed sedimentary events questionable. Here we attempt to remove this question mark by presenting sedimentary traces of CRs in the 370-year-long varved sequence of Köyceğiz Lake (SW Turkey) that we compare with estimated peak ground acceleration (PGA) values of several nearby earthquakes. We find that earthquakes exceeding estimated PGA values of ~20 cm/s2 can induce soft-sediment deformations, while CRs seem only to be triggered by PGA levels higher than 70 cm/s2. In Köyceğiz Lake, CRs produce Cr- and Ni-enriched sedimentation due to the seismically mobilized soils derived from ultramafic rocks in the catchment. Given the varve chronology, the residence time of the seismically mobilized material in the catchment is determined to be 5 to 10 years.

  11. [Study of acute vulvovaginitis in sexually active adult women, with special reference to candidosis, in patients of the Francisco J. Muñiz Infectious Diseases Hospital].

    PubMed

    Buscemi, Luis; Arechavala, Alicia; Negroni, Ricardo

    2004-12-01

    The results of microbiological vaginal secretions samples obtained from 749 women (from July 2001 to July 2002) were studied in the Bacteriology Unit of the Francisco Javier Muñiz Hospital from Buenos Aires. All patients suffered acute vulvovaginitis were child bearing and sexually active women, 334 of them were HIV-positive. The following are the results of the microbiological studies: Lactobacillus spp 50.6%, Gardnerella vaginalis 25.6%, Candida spp 17.4%, Trichomonas vaginalis 5.3%, Neisseria gonorrhoeae 0.3% and B group Streptococcus 0.8%. Candida vaginitis was significantly more frequent in HIV-positive patients, (21.6% vs 14%; p = 0.0086); meanwhile, trichomoniasis was less common although the difference was not statistically significant (3.6 vs 6.7%, p = 0.0810). The following Candida species were isolated in this study: Candida albicans 76.8%, Candida glabrata 15.6%, Candida parapsilosis 2.9%, Candida tropicalis 1.5% and Candida krusei 0.7%. Eight cases (6.2%) of vaginitis were produced by two Candida species (C. albicans and C. glabrata), and in three cases (2.17%) Saccharomyces cerevisiae were isolated. Five women suffering acute vaginitis with Candida spp presented another etiologic agent of vaginal infection, three cases T. vaginalis and two cases G. vaginalis. The following are some of the most important findings of this study: 1) Half of the patients presented a normal microbial biota; 2) Candida spp vaginitis was significantly more frequent among HIV-positive women; 3) we observed a high incidence of Candida glabrata infections (15.9%), 4) 6.2% of vaginal candidiasis were caused by more than one Candida species and, 5) the susceptibility pattern of C. albicans and C. glabrata isolates against fluconazole was similar to the one observed in other studies. The majority of C. albicans isolates were susceptible to fluconazole (MIC90 = 0.5 microg/ml) meanwhile C. glabrata strains were much less susceptible to this drug (MIC50 and MIC90 = 32 microg/ml).

  12. [Efficacy of the treatment and secondary antifungal prophylaxis in AIDS-related histoplasmosis. Experience at the Francisco J. Muñiz Infectious Diseases Hospital in Buenos Aires].

    PubMed

    Negroni, Ricardo; Messina, Fernando; Arechavala, Alicia; Santiso, Gabriela; Bianchi, Mario

    Classic histoplasmosis is a systemic endemic mycosis due to Histoplasma capsulatum var. capsulatum. A significant reduction in the morbidity and mortality of AIDS-related histoplasmosis has been observed since the introduction of highly active antiretroviral therapy (HAART) and secondary antifungal prophylaxis. The aim of this study was to determine the current state of prognosis and treatment response of HIV-positive patients with histoplasmosis in the Francisco J. Muñiz Infectious Diseases Hospital in Buenos Aires City. A retrospective study was conducted using the demographic, clinical, immunological and treatment data of 80 patients suffering from AIDS-related histoplasmosis. Of the 80 cases studied 65 were male, the median age was 36 years, with 73.7% of the patients being drug addicts, 82.5% of the patients was not receiving HAART at diagnosis, and 58.7% of the cases had less than 50 CD4+ cells/μl at the beginning of the treatment. The initial phase of treatment consisted of intravenous amphotericin B and/or oral itraconazole for 3 months, with 78.7% of the cases showing a good clinical response. Only 26/63 patients who were discharged from hospital continued with the follow-up of the HAART, secondary prophylaxis with itraconazole or amphotericin B. Secondary prophylaxis was stopped after more than one year of HAART if the patients were asymptomatic, had two CD4+ cell counts greater than 150cells/μl, and undetectable viral loads. No relapses were observed during a two-year follow up after prophylaxis was stopped. The treatment of histoplasmosis in HIV-positive patients was effective in 78.8% of the cases. The combination of HAART and secondary antifungal prophylaxis is safe, well tolerated, and effective. The low adherence of patients to HAART and the lack of laboratory kits for rapid histoplasmosis diagnosis should be addressed in the future. The usefulness of primary antifungal prophylaxis for cryptococcosis and histoplasmosis HIV-positive patients

  13. Metal Accumulations in Water, Sediment, Crab (Callinectes sapidus) and Two Fish Species (Mugil cephalus and Anguilla anguilla) from the Köyceğiz Lagoon System-Turkey: An Index Analysis Approach.

    PubMed

    Genç, Tuncer Okan; Yilmaz, Fevzi

    2017-08-01

    The concentrations of six metals (Hg, Cd, Cu, Pb, Cr and Zn) individual total metal load (IMBI) values and its relation to condition index were determined in water, sediment and tissues of crab (Callinectes sapidus) and two fish species (Mugil cephalus and Anguilla anguilla) inhabiting Köyceğiz Lagoon System. The average distribution of the IMBI values ranged from 0.033 to 0.265. Distribution patterns of IMBI in species follow the sequence: A. anguilla > M. cephalus > C. sapidus. Results showed that there are positive relationships between species sizes and metal levels in most cases. The concentrations of Pb in muscle in the three studied species were in all cases considerably higher than the maximum levels set by law. Average Cd, Cu and Zn values in M. cephalus were also higher than the limits proposed for fish by FAO/WHO, EC and TFC. Therefore, the human consumption of all analysed species is not recommended.

  14. Three Types of Condensed Cluster Phases of Rare-Earth Metal Iodides with Transition Metal Interstitials: Pr 4I 5Ni, Pr 3I 3Os, Pr 2INi 2, and La 2IZ 2

    NASA Astrophysics Data System (ADS)

    Park, Younbong; Martin, James D.; Corbett, John D.

    1997-03-01

    Syntheses of the title compounds result from appropriate reactions of the elements andRI3(R=La, Pr) in sealed Nb containers at, variously, 800-990°C. The structures of three were detailed by single crystal X-ray diffraction: Pr4I5Ni,Pmmn,Z=2,R(F)/Rw=3.6/5.3%; Pr3I3Os,P21/m,Z=2,R/Rw2.4/2.8%; Pr2INi2,P63/mmc,Z=2,R/Rw=2.2/3.6. The new compounds La2IZ2,Z=Fe, Co, Ru, Os, were shown to be isostructural with Pr2INi2(Gd2IFe2) by Guinier powder diffraction. Pr4I5Ni, the first orthorhombic example among theR4I5Zseries, consists ofR6Zoctahedra condensed into chains. The new example contains the most extremeR:Zsize proportions and clearly lacks the strongdπ-dπbonding betweenZand apicalRseen within other members. Pr3I3Os, previously known only with a cubic Gd3Cl3C-(Ca3I3P-)-type structure, also occurs as a relatively undistorted member of the monoclinic Pr3I3Ru (double chain) family. Apical Pr-Osπ-bonding appears significant, with Pr-Os distances that are 0.24 Å shorter than the average within the waist of the parent octahedra. TheR2IZ2phases expand the number of examples of the unusual Gd2IFe2structure, which contains AlB2-like slabs; namely, graphite-likeZ2nets between eclipsed pairs ofRlayers that are in turn separated by single iodine layers. Notable distances in Pr2INi2are Ni-Ni, 2.36 Å, and Pr-Ni, 2.98 Å. Charge-consistent, extended Hückel band calculations in La2IFe2(in contrast with results reported for Gd2IFe2) demonstrate a strong mixing of La-Fe and Fe-Fe bonding in a partially filled band, the Fe states on balance falling only slightly below those of La.

  15. Ab initio structures for 90 degrees -twisted s-trans-1,3-butadiene and cyclooctatetraene: the naked sp2-sp2 bond.

    PubMed

    Feller, David; Craig, Norman C; Matlin, Albert R

    2008-03-20

    The bond length of a carbon-carbon sp2-sp2 sigma-bond without the perturbing effects of pi-interactions has been estimated by high level calculations on two prototypical systems: a 90 degrees -twisted form of butadiene and the tub conformer of cyclooctatetraene. The former system yields a value of 1.4818 A, considerably longer than previous estimates. The corresponding bond length in the latter is slightly shorter due to some pi-electron delocalization.

  16. Synthesis of (+)-(R)- and (-)-(S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)] aminotetralin: new 5-HT1A receptor ligands.

    PubMed

    Zhuang, Z P; Kung, M P; Clarke, W; Maayani, S; Mu, M; Kung, H F

    1995-01-01

    (R,S)-trans-8-Hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)amino]tetralin 7, a new radioiodinated ligand based on 8-OH-DPAT, was reported as a potential ligand for 5-HT1A receptors. The optically active (+)-(R)- and (-)-(S)-7 were prepared to investigate the stereoselectivity of (R,S)-7. Racemic intermediate 8-methoxy-2-N-n-propyltetralin was reacted with the acyl chloride of (-)-(R)-O-methylmandelic acid to form a mixture of (S,R)- and (R,R)-diastereoisomers, which were separated by flash column chromatography. After removing the N-acyl group from the diastereoisomers, the desired (+)-(R)- or (-)-(S)-7 was obtained by adding an N-iodopropenyl group. In vitro homogenate binding studies showed the stereoselectivity of this new compound for 5-HT1A receptors. (+)-(R)-7 isomer displayed 100-fold higher affinity than the (-)-(S)-7 isomer. Biochemical study indicated that (+)-(R)-7 potently inhibited forskolin-stimulated adenylyl cyclase activity in hippocampal membranes (Emax and EC50 were 24.5% and 5.4 nM, respectively), while (-)-(S)-7 showed no effect at 1 microM. The radioiodinated (+)-(R)- and (-)-(S)-[125I]7 were confirmed by coelution with the resolved unlabeled compound on HPLC (reverse phase column PRP-1, acetonitrile/pH 7.0 buffer, 80/20). The active isomer, (+)-(R)-[125I]7, displayed high binding affinity to 5-HT1A receptors (Kd = 0.09 +/- 0.02 nM). In contrast, the (-)-(S)-7 isomer displayed a significantly lower affinity to the 5-HT1A receptor (Kd > 10 nM).(ABSTRACT TRUNCATED AT 250 WORDS)

  17. Remedial Investigation Addendum Report Data Item A009. Volume 4: Appendices I-Z

    DTIC Science & Technology

    1993-12-01

    wetland. Functions and values were evaluated in a Level 2 WET assessment, which is generally considered to be a reasonable balance between time, available...spp. Bog Hemp Boehmeria cylindrica FACW+ Water Shield Brasenia schreberi OBL Coontail Ceratophyllum demersum OBL’) Goldthread Coptis trifolia FACW...having a better balance of number of organisms (abundance) per number of taxa. This also suggests that Cold Spring Brook Pond may be impacted relative

  18. Evaluation of Dipsol IZ-C17 LHE Zinc-Nickel Plating (Briefing Charts)

    DTIC Science & Technology

    2007-01-24

    Bath Easier to Maintain • Throwing Power Good and No Variance in % Ni 6. ENVIRONMENTAL ASSURANCE Zn-Ni Versions for Aerospace and Automotive Industry... Aerospace Needs a Different Version of Automotive Zn-Ni Plating – High Strength Steel Used In Aerospace • Hydrogen Embrittlement • Fatigue Life...Corrosion Performance • Aerospace Parts Required to Have a Longer Service Life and Higher Reliability Than Automotive 7. ENVIRONMENTAL ASSURANCE Pre

  19. Production of alcohol from Jerusalem artichoke for gasoline additive. Proucavanje mogucnosti proizvodnje alkohola iz topinambura kao dodatka u benzin

    SciTech Connect

    Pekic, B.; Kisgeci, J.

    1984-01-01

    Trials conducted in 1980 and 1981 on three soil types, chernozem (a rich soil), anthropogenized black sand (a medium-rich soil), and anthropogenized brown sand (a poor soil), showed that the Jerusalem artichoke was superior to conventional field crops (corn, sugarbeet, potato, and sorghum) regarding the yield of carbohydrates per unit area, especially when grown on the poor soil. The analyses of the technological properties of Jerusalem artichokes grown for two years in the experimental plots showed that the plant species is a quality raw material for the production of alcohol. From the aspect of alcohol production, the quality of the tested varieties of Jerusalem artichoke depended neither on soil quality nor on the delay in harvesting the crop after it reached technological maturity. The results of the study indicate that the alcohol production from Jerusalem artichokes would be more economic, i.e., more profitable, than the production from conventional raw materials. The study of the carbohydrate composition of Jerusalem artichoke tubers made it clear that besides alcohol production, Jerusalem artichokes are a good raw material for the production of high-fructose syrup and crystalline fructose. Since the interest in these products kept increasing in recent years, because of their exceptional characters, it is necessary to establish research programs to cover these field too. In the course of the study the authors came across some interesting literature data on the use of Jerusalem artichokes as a raw material for the production of high-fructose syrup and crystalline fructose. Some of the publication, i.e., those that might be useful in further research work, are appended to this study.

  20. Stress Corrosion-Cracking and Corrosion Fatigue Impact of IZ-C17+ Zinc Nickel on 4340 Steel

    DTIC Science & Technology

    2017-05-17

    carcinogen and alternatives have been sought which are similarly effective but have minimal environmental , safety, and health risks. Aluminum is...carcinogen and alternatives have been sought which are similarly effective but have minimal environmental , safety, and health risks. Aluminum is effective...Passivated with a Chromate Conversion Coating

  1. VizieR Online Data Catalog: iz follow-up photometry of HAT-P-65 and HAT-P-66 (Hartman+, 2016)

    NASA Astrophysics Data System (ADS)

    Hartman, J. D.; Bakos, G. A.; Bhatti, W.; Penev, K.; Bieryla, A.; Latham, D. W.; Kovacs, G.; Torres, G.; Csubry, Z.; de Val-Borro, M.; Buchhave, L.; Kovacs, T.; Quinn, S.; Howard, A. W.; Isaacson, H.; Fulton, B. J.; Everett, M. E.; Esquerdo, G.; Beky, B.; Szklenar, T.; Falco, E.; Santerne, A.; Boisse, I.; Hebrard, G.; Burrows, A.; Lazar, J.; Papp, I.; Sari, P.

    2017-05-01

    Both HAT-P-65 and Both HAT-P-66 were selected as candidate transiting planet systems based on Sloan r-band photometric time series observations carried out with the HATNet telescope network. HATNet consists of six 11cm aperture telephoto lenses, each coupled to an APOGEE front-side-illuminated CCD camera, and each placed on a fully automated telescope mount. Four of the instruments are located at Fred Lawrence Whipple Observatory (FLWO) in Arizona, USA, while two are located on the roof of the Submillimeter Array hangar building at Mauna Kea Observatory (MKO) on the island of Hawaii, USA. Each instrument observes a 10.6°*10.6° field of view. We conducted follow-up photometric time series observations of each object using KeplerCam on the 1.2m telescope at FLWO. HAT-P-65 was observed on 2009 Sep-Dec with a r-band filter using the HAT-6/G342 (located at FLWO) and the HAT-8/G342 (located on the roof of the Smithsonian Astrophysical Observatory Submillimeter Array hangar building at Mauna Kea Observatory in Hawaii), and on 2011 Jun 10 (i filter), 2011 Jun 26 (i filter), 2011 Jul 14 (i filter), 2011 Sep 20 (i filter), 2013 Sep 16 (z filter), 2013 Sep 29 (i filter), and 2013 Oct 04 (i filter) using the FLWO 1.2m/KeplerCam. HAT-P-66 was observed on 2011 Feb-2012 Mar using the HAT-10/G101 (located at FLWO) with a r-band filter, using the HAT-6/G101 (located at FLWO) with a r-band filter, and using the HAT-7/G101 (located at FLWO) with a r-band filter, on 2011 Feb-2012 Apr using the HAT-5/G101 (located at FLWO) with a r-band filter, on 2011 May-2012 Jun using the HAT-8/G101 (located on the roof of the Smithsonian Astrophysical Observatory Submillimeter Array hangar building at Mauna Kea Observatory in Hawaii) with a r-band filter, on 2011 Oct-2012 Jan using the HAT-9/G101 (located at FLWO) with a r-band filter, and on 2015 Apr 29 (i filter), 2015 Nov 26 (z filter), 2015 Dec 08 (i filter) using the FLWO 1.2m/KeplerCam. Spectroscopic observations of both HAT-P-65 and HAT-P-66 were carried out using the Tillinghast Reflector Echelle Spectrograph (TRES) on the 1.5m Tillinghast Reflector at FLWO (on 2010 Oct 27 for HAT-P-65, and 2014 Nov-2015 Jun for HAT-P-66), and the HIgh-Resolution Echelle Spectrometer (HIRES) on the Keck I 10m at Mauna Kea Observatory (MKO) on the island of Hawaii, USA (on 2010 Dec 14 and 2010 Dec-2013 Aug for HAT-P-65, and on 2016 Feb 3 and 2015 Dec-2016 Jan for HAT-P-66). For HAT-P-65 we also obtained observations on 2010 Aug 21-22 and 2011 Oct 8 using the Fibre-fed Echelle Spectrograph (FIES) on the 2.5m Nordic Optical Telescope (NOT) at the Observatorio del Roque de los Muchachos on the Spanish island of La Palma. For HAT-P-66 spectroscopic observations were also collected on 2015 Mar-2016 Jan using the SOPHIE spectrograph on the 1.93m telescope at the Observatoire de Haute-Provence (OHP) in France. The light curve measurements are available in Table2. The individual radial velocity and bisector span measurements are made available in Table4. (5 data files).

  2. DETERMINATION OF C1 AND Cx CELLULOLYTIC ACTIVITIES IN ENZYME PREPARATIONS OF MOLD FUNGI (Opredelenie C1 i Cx Tsellyuloliticheskikh Aktivnostei v Fermentnykh Preparatakh iz Plesnevykh Gribov),

    DTIC Science & Technology

    Trichotecium roseum, Aspergillus awamory, Asp. niger, Asp. flavus . Differences in the distribution of C1 - and Cx - activities in the preparations of various strains of the same fungus (Asp. awamory, Asp. oryzae) are shown. (Author)

  3. Silver bullet or trojan horse? The effects of inclusionary zoning on local housing markets in the United States.

    PubMed

    Schuetz, Jenny; Meltzer, Rachel; Been, Vicki

    2011-01-01

    Many local governments are adopting inclusionary zoning (IZ) as a means of producing affordable housing without direct public subsidies. In this paper, panel data on IZ in the San Francisco metropolitan area and suburban Boston are used to analyse how much affordable housing the programmes produce and how IZ affects the prices and production of market-rate housing. The amount of affordable housing produced under IZ has been modest and depends primarily on how long IZ has been in place. Results from suburban Boston suggest that IZ has contributed to increased housing prices and lower rates of production during periods of regional house price appreciation. In the San Francisco area, IZ also appears to increase housing prices in times of regional price appreciation, but to decrease prices during cooler regional markets. There is no evidence of a statistically significant effect of IZ on new housing development in the Bay Area.

  4. Growth Disorders

    MedlinePlus

    ... well — the condition is called hypopituitarism (say: hy-po-pih-TOO-eh-ter-iz-em). This can ... little, the condition is called hypothyroidism (say: hy-po-THY-royd-iz-em). Having too little thyroxine ...

  5. Structure modeling and growing AgClхBr1-х, Ag1-xTlxBr1-xIx, and Ag1-xTlxClyIzBr1-y-z crystals for infrared fiber optics

    NASA Astrophysics Data System (ADS)

    Korsakov, Alexandr; Zhukova, Liya; Korsakova, Elena; Zharikov, Evgenii

    2014-01-01

    In this paper we describe the aggregate technology of producing variable composition crystals, based on the solid solutions of silver and Tl+-doped halides for creating infrared photonic crystal fibers in the spectral range of 2-40 μm by extruding, we also produce all the necessary equipment. We specified the minimum melting point position for the AgCl-AgBr phase diagram. We also investigated the fundamental physical properties of new crystals and fibers: transmission losses, transmission range, refraction index, hardness, and density.

  6. Potential energy profile, structural, vibrational and reactivity descriptors of trans-2-methoxycinnamic acid by FTIR, FT-Raman and quantum chemical studies

    NASA Astrophysics Data System (ADS)

    Arjunan, V.; Anitha, R.; Thenmozhi, S.; Marchewka, M. K.; Mohan, S.

    2016-06-01

    The stable conformers of trans-2-methoxycinnamic acid (trans-2MCA) are determined by potential energy profile analysis. The energies of the s-cis and s-trans conformers of trans-2MCA determined by B3LYP/cc-pVTZ method are -612.9788331 Hartrees and -612.9780953 Hartrees, respectively. The vibrational and electronic investigations of the stable s-cis and s-trans conformers of trans-2-methoxycinnamic acid have been carried out extensively with FTIR and FT-Raman spectral techniques. The s-cis conformer (I) with a (C16-C17-C18-O19) dihedral angle equal to 0° is found to be more favoured relative to the one s-trans (II) with (C16-C17-C18-O19) = 180°, possibly due to delocalization, hydrogen bonding and steric repulsion effects between the methoxy and acrylic acid groups. The DFT studies are performed with B3LYP method by utilizing 6-311++G** and cc-pVTZ basis sets to determine the structure, thermodynamic properties, vibrational characteristics and chemical shifts of the compound. The total dipole moments of the conformers determined by B3LYP/cc-pVTZ method are 3.35 D and 4.87 D for s-cis and s-trans, respectively. It reveals the higher polarity of s-trans conformer of trans-2MCA molecule. The electronic and steric influence of the methoxy group on the skeletal frequencies has been analysed. The energies of the frontier molecular orbitals and the LUMO-HOMO energy gap have been determined. The MEP of s-cis conformer lie in the range +1.374e × 10-2 to -1.374e × 10-2 while for s-trans it is +1.591e × 10-2 to -1.591e × 10-2. The total electron density of s-cis conformer lie in the range +5.273e × 10-2 to -5.273e × 10-2 while for s-trans it is +5.403e × 10-2 to -5.403e × 10-2. The MEP and total electron density shows that the s-cis conformer is less polar, less reactive and more stable than the s-trans conformer. All the reactivity descriptors of the molecule have been discussed. Intramolecular electronic interactions and their stabilisation energies have analysed

  7. Magnetic source imaging in posterior cortex epilepsies.

    PubMed

    Badier, Jean-Michel; Bartolomei, Fabrice; Chauvel, Patrick; Bénar, Christian-George; Gavaret, Martine

    2015-01-01

    Posterior cortex epilepsies (PCE) are characterized by less satisfying postoperative results than temporal lobe epilepsies and are thus challenging for non-invasive presurgical investigations. The objective of this study was to evaluate the performance of magnetic source imaging (MSI) in PCE, validating the results by the SEEG (stereoelectroencephalography) definition of irritative and epileptogenic zones (IZ and EZ). Fourteen PCE surgery candidates were investigated using MSI and SEEG. LCMV (Linearly Constrained Minimum Variance) and MUSIC algorithms were used. IZ was quantified using a semi-automatic detection of interictal spikes. EZ was quantified using the epileptogenicity index (EI) method that accounts for both the propensity of a brain area to generate rapid discharges and the time for this area to get involved in the seizure. EI values range from 0 (no epileptogenicity) to 1 (maximal epileptogenicity). Levels of concordance between MSI and IZ, MSI and EZ were determined as follows: A = localized on MSI and SEEG for the site of value 1 (IZ and EZ quantification), B = localized on MSI and SEEG for a part of the IZ or a structure involved in the EZ (without the maximal value 1), C = localized on MSI and not SEEG, D = localized on SEEG and not MSI, E = localized on MSI and SEEG, discordant for site. Five PCE cases were characterized by focal IZ, nine by distributed IZ between several distant brain areas. MSI allowed to determinate IZ in 4/5 focal IZ cases. In case of distributed IZ, levels of concordance were A (2 cases), B (4 cases) and D (3 cases). In most distributed cases, MSI allowed to localize only a part of the IZ. Medial temporal involvement in the IZ was frequent (9/12 cases) and not evidenced by MSI. The brain area that demonstrated the maximal value of EI was shown by MSI in four out of five (80 %) focal IZ cases, in two out of nine (22 %) distributed cases. MSI results depend on IZ characteristics. A distributed IZ organization

  8. A taxonomic monograph of the leaf-litter inhabiting weevil genus Plumolepilius new genus (Coleoptera: Curculionidae: Molytinae: Conotrachelini) from Mexico, Guatemala, and El Salvador.

    PubMed

    Barrios-Izás, Manuel A; Anderson, Robert S; Morrone, Juan J

    2016-09-14

    We describe the Mesoamerican leaf litter weevil genus Plumolepilius Barrios-Izás & Anderson, new genus (Coleoptera: Curculionidae: Molytinae: Conotrachelini) (type species P. trifiniensis Barrios-Izás & Anderson, new species), species of which inhabit mountain ecosystems from the state of Chiapas in southeastern Mexico to northern Panama. In this paper we describe nine new species from Mexico, Guatemala, and El Salvador: P. trifiniensis Barrios-Izás & Anderson, new species (El Salvador and Guatemala); P. branstetteri Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. longinoi Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. cortezi Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. canoi Barrios-Izás & Anderson, new species (Guatemala); P. schusteri Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. daryi Barrios-Izás & Anderson, new species (Guatemala); P. yolnabajensis Barrios-Izás & Anderson, new species (Guatemala); and P. macalajauensis Barrios-Izás & Anderson, new species (Guatemala).        The genus and the species are named and described, information on their geographical distributions is given and images of the habitus of both sexes and the aedeagus are presented. A key to the species of Plumolepilius based on males is included.        The monophyly of Plumolepilius was confirmed by a parsimony analysis of external and male aedeagus morphology and the genus is best characterized by the presence of plumose scales lining the prosternal channel. Phylogenetic analysis supports that Lepilius Champion 1905 is the sister genus of Plumolepilius.

  9. A Preservice Teacher's Delivery of Sport Education: Influences, Difficulties and Continued Use

    ERIC Educational Resources Information Center

    Deenihan, J. T.; MacPhail, Ann

    2013-01-01

    How preservice teachers (PSTs) learn and deliver Sport Education ("SE") (Siedentop, 1994) is an area researchers believe warrants further investigation (Stran & Curtner-Smith, 2009a). This study explores one PST's experiences delivering SE during a school teaching placement after undertaking a practical "SE" module in his…

  10. "Living the Curriculum": Integrating Sport Education into a Physical Education Teacher Education Programme

    ERIC Educational Resources Information Center

    Deenihan, J. T.; McPhail, Ann; Young, Ann-Marie

    2011-01-01

    This study recognizes the paucity of research regarding how pre-service teachers learn to use Sport Education (SE) in their Physical Education Teacher Education (PETE) programmes (Stran and Curtner-Smith, 2010). The study provides an opportunity in PETE where pre-service teachers "live the curriculum" (Oslin et al., 2001) and experience…

  11. Quantitative Infrared Absorption Spectra and Vibrational Assignments of Crotonaldehyde and Methyl Vinyl Ketone Using Gas-Phase Mid-Infrared, Far-Infrared, and Liquid Raman Spectra: s-cis vs s-trans Composition Confirmed via Temperature Studies and ab Initio Methods

    SciTech Connect

    Lindenmaier, Rodica; Williams, Stephen D.; Sams, Robert L.; Johnson, Timothy J.

    2016-12-16

    Methyl vinyl ketone (MVK) and crotonaldehyde are chemical isomers; both are also important species in tropospheric chemistry. We report quantitative vapor-phase infrared spectra of crotonaldehyde and MVK vapors over the 540-6500 cm-1 range. Vibrational assignments of all fundamental modes are made for both molecules based on far- and mid-infrared vapor-phase spectra, liquid Raman spectra, along with density functional theory and ab initio MP2 and high energy-accuracy compound theoretical models (W1BD). Theoretical results indicate that at room temperature the crotonaldehyde equilibrium mixture is approximately 97% s-trans and only 3% s-cis conformer. Nearly all observed bands are thus associated with the s-trans conformer, but a few appear to be uniquely associated the s-cis conformer, notably ν16c at 730.90 cm-1, which displays a substantial intensity increase with temperature (62% upon going from 5 to 50 oC). The intensity of the corresponding mode of the s-trans conformer decreases with temperature. Under the same conditions, the MVK equilibrium mixture is approximately 69% s-trans conformer and 31% s-cis. W1BD calculations indicate that for MVK this is one of those (rare) cases where there are comparable populations of both conformers, ~doubling the number of observed bands and exacerbating the vibrational assignments. We uniquely assign the bands associated with both the MVK s-cis conformer as well as those of the s-trans, thus completing the vibrational analyses of both conformers from the same set of experimental spectra. Integrated band intensities are reported for both molecules along with global warming potential values. Using the quantitative IR data, potential bands for atmospheric monitoring are also discussed.

  12. Differences between motor point and innervation zone locations in the biceps brachii. An exploratory consideration for the treatment of spasticity with botulinum toxin.

    PubMed

    Guzmán-Venegas, Rodrigo A; Araneda, Oscar F; Silvestre, Rony A

    2014-12-01

    Botulinum toxin (BTX) acts on the neuromuscular junction which can be located by the innervation zone (IZ). Clinically, the motor point (MP) is homologous to the IZ and it is used as the injection site of BTX. Differences in the effectiveness of the application of BTX between MP and IZ locations have been determined. Compare the location of the MP obtained using electrical stimulation and the location of the IZ using a linear surface electrodes array on the biceps brachii muscle. The biceps brachii muscle of twenty men was assessed. The MP was located using the torque measurement generated by electrical stimulation. The IZ was detected using a linear surface electrodes array. A difference between the MP and the IZ positions (75.8 vs. 86.5mm, delta 10.7 mm; p=0.003, post-hoc power 0.89) was observed. The magnitude of the difference between the MP and the IZ may be clinically relevant. The IZ location using surface electromyography as a guide to optimize BTX injection is proposed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Is Inclusionary Zoning Inclusionary? A Guide for Practitioners. Technical Report

    ERIC Educational Resources Information Center

    Schwartz, Heather L.; Ecola, Liisa; Leuschner, Kristin J.; Kofner, Aaron

    2012-01-01

    Inclusionary zoning (IZ) has become an increasingly popular tool for providing affordable housing in an economically integrative manner. IZ policies typically require developers to set aside a proportion of units in market-rate residential developments to be made affordable for lower-income households in exchange for development rights or zoning…

  14. Characterizing and Quantifying Local and Regional Particulate Matter Emissions From Department of Defense Installations

    DTIC Science & Technology

    2005-01-07

    Elza Cushing and Hector Moldanado also of the Directorate of the Environment helped us out in numerous ways. The personnel of...0.51 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 0 1 2 3 4 Disturbance Level N or m al iz ed q /u * Figure 4.31. The observed relationship between...al iz ed q /u * Without sand feed N or m al iz ed q /u * N or m al iz ed q /u * 0 0 1 2 3 4 Disturbance Level N or m al iz ed q /u *

  15. Whither Strategic Communication? A Survey of Current Proposals and Recommendations

    DTIC Science & Technology

    2009-01-01

    eo rg an iz e at D O S R eo rg an iz e at D...o D Pr es id en ti al D ir ec ti ve /R eo rg an iz e at W h it e H o u se R eb al an ce A u th o ri ty B et w ee n A g en ci es N ew C o o...ep en d en t Su p p o rt in g O rg R eo rg an iz e at D O S R eo rg an iz e at D o D Pr es id en ti al D ir ec

  16. New Conceptual Model for Soil Treatment Units: Formation of Multiple Hydraulic Zones during Unsaturated Wastewater Infiltration.

    PubMed

    Geza, Mengistu; Lowe, Kathryn S; Huntzinger, Deborah N; McCray, John E

    2013-07-01

    Onsite wastewater treatment systems are commonly used in the United States to reclaim domestic wastewater. A distinct biomat forms at the infiltrative surface, causing resistance to flow and decreasing soil moisture below the biomat. To simulate these conditions, previous modeling studies have used a two-layer approach: a thin biomat layer (1-5 cm thick) and the native soil layer below the biomat. However, the effect of wastewater application extends below the biomat layer. We used numerical modeling supported by experimental data to justify a new conceptual model that includes an intermediate zone (IZ) below the biomat. The conceptual model was set up using Hydrus 2D and calibrated against soil moisture and water flux measurements. The estimated hydraulic conductivity value for the IZ was between biomat and the native soil. The IZ has important implications for wastewater treatment. When the IZ was not considered, a loading rate of 5 cm d resulted in an 8.5-cm ponding. With the IZ, the same loading rate resulted in a 9.5-cm ponding. Without the IZ, up to 3.1 cm d of wastewater could be applied without ponding; with the IZ, only up to 2.8 cm d could be applied without ponding. The IZ also plays a significant role in soil moisture distribution. Without the IZ, near-saturation conditions were observed only within the biomat, whereas near-saturation conditions extended below the biomat with the IZ. Accurate prediction of ponding is important to prevent surfacing of wastewater. The degree of water and air saturation influences pollutant treatment efficiency through residence time, volatility, and biochemical reactions.

  17. Selective determination of isoniazid using bentonite clay modified electrodes.

    PubMed

    Azad, Uday Pratap; Prajapati, Nandlal; Ganesan, Vellaichamy

    2015-02-01

    Fe(dmbpy)3(2+) (where dmbpy is 4,4'-dimethyl-2,2'-bipyridine) was immobilized by ion-exchange in a bentonite clay film coating on a glassy carbon electrode. Cyclic voltammetry characteristics of the immobilized Fe(dmbpy)3(2+) were stable and reproducible corresponding to the Fe(dmbpy)3(2+/3+) redox process. In the presence of isoniazid (IZ), the electrogenerated in film Fe(dmbpy)3(3+) oxidized IZ efficiently producing large anodic current. This current was linearly proportional to the IZ concentration in the solution. The process was described by an EC' electrocatalysis mechanism allowing for sensitive determination of IZ with a wide linear dynamic concentration range of 10.0μM to 10.0mM. The electrode was tested for its analytical suitability and possible discrimination of interferences by determining IZ in a commercially available pharmaceutical product. The paper reports on a simple, cheap, and easy to fabricate chronoamperometric chemical sensor for determination of IZ. Kinetic parameters, such as the catalytic rate constant (2.3×10(3)M(-1)s(-1)) and diffusion coefficient of IZ (5.42×10(-5)cm(2)s(-1)), were determined using CV, chronoamperometry, and chronocoulometry. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Reconstitution of myocardial lymphatic vessels after acute infarction of rat heart.

    PubMed

    Sun, Q N; Wang, Y F; Guo, Z K

    2012-06-01

    We investigated the regeneration of cardiac lymphatic vessels and capillaries in the infarcted myocardiac zones after acute myocardial infarction in rats. The anterior descending artery of the heart was ligated for infarction and both immunohistochemistry and immunofluorescence were used to detect pathological changes of lymphatic vessels in infarcted zone (IZ), infarcted margin zone (MZ) and remote margin zone (RMZ) on days 7, 14, 21, and 28 after surgery. Dynamic variation of lymphatic vessels existed in IZ, MZ and RMZ at different stages after surgery. At day 7, lymphatic vessels and capillaries were not seen in the IZ, very thin lymphatic capillaries were obviously increased in the inner layer of the margin zone, and enlarged and increased lymphatic capillaries were found in the outer layer of margin zone. At 14 days, a few sparsely arranged lymphatic capillaries were observed in the IZ without marked changes in the MZ. At 21 days, constricted regenerating lymphatic capillaries in MZ were decreased, and lymphatic vessels exhibited sprouting towards the IZ. At 28 days, more lymphatic capillaries emerged in the IZ, and the morphology and number of lymphatic vessels and capillaries had returned to normal. There were no marked changes of lymphatic vessels and capillaries in RMZ compared to control myocardium at the 4 time points. This study demonstrates varied remodeling of lymphatic vessels and capillaries in the IZ and MZ after acute myocardial infarction, and these changes in lymphatic vessels likely play an important role for recovery of infarcted myocardiac function.

  19. Mechanical strength and subcritical crack growth under wet cyclic loading of glass-infiltrated dental ceramics.

    PubMed

    Salazar Marocho, Susana M; Studart, André R; Bottino, Marco A; Bona, Alvaro Della

    2010-05-01

    Evaluate the flexural strength (sigma) and subcritical crack growth (SCG) under cyclic loading of glass-infiltrated alumina-based (IA, In-Ceram Alumina) and zirconia-reinforced (IZ, In-Ceram Zirconia) ceramics, testing the hypothesis that wet environment influences the SCG of both ceramics when submitted to cyclic loading. Bar-shaped specimens of IA (n=45) and IZ (n=45) were fabricated and loaded in three-point bending (3P) in 37 degrees C artificial saliva (IA(3P) and IZ(3P)) and cyclic fatigued (F) in dry (D) and wet (W) conditions (IA(FD), IA(FW), IZ(FD), IZ(FW)). The initial sigma and the number of cycles to fracture were obtained from 3P and F tests, respectively. Data was examined using Weibull statistics. The SCG behavior was described in terms of crack velocity as a function of maximum stress intensity factor (K(Imax)). The Weibull moduli (m=8) were similar for both ceramics. The characteristic strength (sigma(0)) of IA and IZ was and 466MPa 550MPa, respectively. The wet environment significantly increased the SCG of IZ, whereas a less evident effect was observed for IA. In general, both ceramics were prone to SCG, with crack propagation occurring at K(I) as low as 43-48% of their critical K(I). The highest sigma of IZ should lead to longer lifetimes for similar loading conditions. Water combined with cyclic loading causes pronounced SCG in IZ and IA materials. The lifetime of dental restorations based on these ceramics is expected to increase by reducing their direct exposure to wet conditions and/or by using high content zirconia ceramics with higher strength. 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  20. Refinement and Verification of Predictive Models of Suspended Sediment Dispersion and Desorption of Toxics from Dredged Sediments.

    DTIC Science & Technology

    1982-07-01

    C ~ DO 680 J=1,NSTEP FOREX =SQRT(ADELX(J+1) *4.* (EZ* ( +EXPCO*EXP( - ’ADELX(J+1)/100.)))) DO 680 IZ=1,21 AZ=(IZ-1) *DELZ TOP=(AZ+XL )/ FOREX - 166 ET...ERF(TOP) BOT= (AZ-XL )/ FOREX EB=ERF (BOT) Z( IZ,J+1)=0. 5*(ET-EB) 680 CONTINUE C C START FINITE DIFFERENCE SOLUTION IF(ISCE.EQ.3)GO TO 25 DO 100 I=IUP

  1. Wireless Intrusion Detection

    DTIC Science & Technology

    2007-03-01

    LEO with Belkin/ Libra spoofing N or m al iz ed O cc ur re nc es Frequency Error (kHz) Figure 3-8 Frequency error Distributions...0.40 0.45 Linksys/CIAMPIAJ1 Linksys/LEO with Belkin/ Libra spoofing N or m al iz ed O cc ur re nc es Received Power (dBm) Figure 3-10...Belkin/ Libra spoofing N or m al iz ed O cc ur re nc es Rise-Time (samples) Figure 3-12 Packet Rise-Time Distributions During Intrusion

  2. Synergy in the spectral tuning of retinal pigments: complete accounting of the opsin shift in bacteriorhodopsin.

    PubMed Central

    Hu, J; Griffin, R G; Herzfeld, J

    1994-01-01

    UV-visible and solid-state NMR studies of a series of 6-s-trans protonated Schiff bases of retinal with aniline show that the bathochromic shift induced by weakening the imine counterion is significantly greater in the 6-s-trans conformation than in the 6-s-cis conformation. Based on the observed magnitude of this coupling between the electronic effects of 6-s isomerization and imine counterion strength in the model compounds, the large opsin shift and unusual chemical shifts in light-adapted bacteriorhodopsin can be fully explained. These phenomena therefore do not require a negative point charge or polarizability effects in the chromophore binding pocket. The results are consistent with an effective center-to-center distance between the Schiff base and its counterion of about 4 A in light-adapted bacteriorhodopsin. PMID:8090738

  3. Comment on 'On Saltiel's isopolarizability approach and its applicability to diphenylpolyenes' by J. Catalán, Chem. Phys. Lett. 635 (2015) 56-59

    NASA Astrophysics Data System (ADS)

    Saltiel, Jack; Turek, Andrzej M.

    2015-10-01

    This is in response to Catalán's objection to our use of isopolarizability conditions in the resolution of the absorption and fluorescence spectra of the s-cis and s-trans all-trans-1.6-diphenyl-1,3,5-hexatriene (ttt-DPH) conformers and the resolution of the fluorescence spectrum of the s-trans conformer to 21Ag → 11Ag and 11Bu → 11Ag spectra. Contrary to Catalán's assertion, we did not assume identical solvatochromic and thermochromic responses of ttt-DPH to medium changes. Those responses depend on a complex combination of factors that can differ from molecule to molecule.

  4. EFFECT OF FUNCTIONAL GROUP CONFORMATION ON THE INFRARED SPECTRA OF SOME GEM DIFUNCTIONAL PHENYLETHYLENE DERIVATIVES,

    DTIC Science & Technology

    each functional group . The two bands for similar functional groups have been ascribed to S-cis- and S-trans- conformations of the carbonyl groups with...Except for the benzalmalononitriles, two functional group stretching vibrations occur in the infrared (i.r.) spectra of the beta,beta-difunctional...styrenes with similar functional groups . For geometrically homogeneous compounds with dissimilar functional groups only one absorption band occurs for

  5. Spectral Tuning of Deep Red Cone Pigments†

    PubMed Central

    Amora, Tabitha L.; Ramos, Lavoisier S.; Galan, Jhenny F.; Birge, Robert R.

    2008-01-01

    Visual pigments are G-protein-coupled receptors that provide a critical interface between organisms and their external environment. Natural selection has generated vertebrate pigments that absorb light from the far-UV (360 nm) to the deep red (630 nm) while using a single chromophore, in either the A1 (11-cis-retinal) or A2 (11-cis-3,4-dehydroretinal) form. The fact that a single chromophore can be manipulated to have an absorption maximum across such an extended spectral region is remarkable. The mechanisms of wavelength regulation remain to be fully revealed, and one of the least well-understood mechanisms is that associated with the deep red pigments. We investigate theoretically the hypothesis that deep red cone pigments select a 6-s-trans conformation of the retinal chromophore ring geometry. This conformation is in contrast to the 6-s-cis ring geometry observed in rhodopsin and, through model chromophore studies, the vast majority of visual pigments. Nomographic spectral analysis of 294 A1 and A2 cone pigment literature absorption maxima indicates that the selection of a 6-s-trans geometry red shifts M/LWS A1 pigments by ~1500 cm−1 (~50 nm) and A2 pigments by ~2700 cm−1 (~100 nm). The homology models of seven cone pigments indicate that the deep red cone pigments select 6-s-trans chromophore conformations primarily via electrostatic steering. Our results reveal that the generation of a 6-s-trans conformation not only achieves a significant red shift but also provides enhanced stability of the chromophore within the deep red cone pigment binding sites. PMID:18370404

  6. System for Computer Automated Typesetting ((SCAT) of Computer Authored Texts.

    DTIC Science & Technology

    1980-07-01

    the strokes of a character. Also type whose characters have serifs. spaceband A space of indeterminate width (though nominally about 1/3 of an em-space...S9,4) <>E7$ THEN 8365 : E8$=’ NDT RANGE"-8360 INPUT D75 -8365 PRINT ’Systes Working...’ 8370 AND (D7$,DF) 8375 STRAN(D7$ R4$()193 24>)R O380 IF D7$=’SfOP

  7. Synthesis of unsymmetrical substituted 1,4-dihydropyridines through thermal and microwave assisted [4+2] cycloadditions of 1-azadienes and allenic esters.

    PubMed

    Singh, Lakhwinder; Ishar, M P Singh; Elango, Munusamy; Subramanian, Venkatesan; Gupta, Vivek; Kanwal, Priyanka

    2008-03-21

    Thermal and microwave assisted [4+2] cycloadditions of 1,4-diaryl-1-aza-1,3-butadienes with allenic esters lead to cycloadducts, which after a 1,3-H shift afford variedly substituted unsymmetrical 2-alkyl-1,4-diaryl-3-ethoxycarbonyl-1,4-dihydropyridines in high yields. Reactions carried out under microwave irradiation are cleaner and give higher yields with much shortened reaction times. Density functional theory (DFT) at the B3LYP/6-31G* level has been used to calculate geometric features of the reactants, barrier for s-trans to s-cis and reverse isomerization of azadienes (5a-d, 10a-e), dihedral angles between N(1), C(2), C(3), and C(4) atoms of azadienes along with various indices such as chemical hardness (eta), chemical potential (micro), global electrophilicity (omega), and the difference in global electrophilicity (Deltaomega) between the reacting pairs and Fukui functions (f (+) and f(-)). The results revealed that s-trans is the predominant conformation of azadienes at ambient temperature and the barrier for conversion of the s-trans rotamer of 1-azadienes to s-cis may be the major factor influencing the chemoselectivity, i.e., [4+2] verses [2+2] cycloaddition. The regiochemistry of the observed cycloadditions is collated with the obtained local electrophilicity indices (Fukui functions). Transition states for the formation of both [4+2] and [2+2] cycloadducts as located at the PM3 level indicate that the transition state for the formation of [4+2] cycloadducts has lower energy, again supporting the earlier conclusion that preferred formation of [4+2] cycloaaducts at higher temperature may be a consequence of barrier for s-trans to s-cis transformation of 1-azadienes.

  8. C14-C15 single bond isomerizations of the retinal chromophore involved in the proton-pumping mechanism of bacteriorhodopsin

    SciTech Connect

    Smith, S.O.; Hornung, I.; van der Steen, R.; Pardoen, J.A.; Braiman, M.S.; Lugtenburg, J.; Mathies, R.A.

    1986-02-01

    Resonance Raman spectroscopy is used to examine the possibility that C14-C15 single bond isomerizations of the retinal prosthetic group are involved in the photochemical reactions of bacteriorhodopsin. Normal mode calculations show that the vibration that contains predominantly C14-C15 stretch character is approx. = 70 cm lower in frequency in the 14-s-cis conformer than in the s-trans case. This geometric effect is insensitive to out-of-plane twists and should be observed in the sterically hindered 13-cis, 14-s-cis retinal protonated Schiff base, which has been proposed as the chromophore in the K and L intermediates of bacteriorhodopsin. Resonance Raman spectra were obtained of K625 by using the low temperature (77 K) spinning-cell technique. Isotopic substitutions with T and SH show that significant C14-C15 stretch character is observed in normal modes at approx. = 1185-1195 cm . The relatively high frequency of the C14-C15 stretch argues that K625 contains a 13-cis, 14-s-trans chromophore. Similarly, isotopic derivatives show that L550 has a localized C14-C15 stretch at 1172 cm , consistent with a 14-s-trans chromophore. These results argue that the primary step in bacteriorhodopsin is a C13=C14 trans cis photoisomerization that does not involve C14-C15 s-cis structures.

  9. C14-C15 single bond isomerizations of the retinal chromophore involved in the proton-pumping mechanism of bacteriorhodopsin

    SciTech Connect

    Smith, S.O.; Hornung, I.; van der Steen, R.; Pardoen, J.A.; Braiman, M.S.; Lugtenburg, J.; Mathies, R.A.

    1986-02-01

    Resonance Raman spectroscopy is used to examine the possibility that C14-C15 single bond isomerizations of the retinal prosthetic group are involved in the photochemical reactions of bacteriorhodopsin. Normal mode calculations show that the vibration that contains predominantly C14-C15 stretch character is approximately equal to 70 cm-1 lower in frequency in the 14-s-cis conformer than in the s-trans case. This geometric effect is insensitive to out-of-plane twists and should be observed in the sterically hindered 13-cis, 14-s-cis retinal protonated Schiff base, which has been proposed as the chromophore in the K and L intermediates of bacteriorhodopsin. Resonance Raman spectra were obtained of K625 by using the low temperature (77 K) spinning-cell technique. Isotopic substitutions with 13C and 2H show that significant C14-C15 stretch character is observed in normal modes at approximately equal to 1185-1195 cm-1. The relatively high frequency of the C14-C15 stretch argues that K625 contains a 13-cis, 14-s-trans chromophore. Similarly, isotopic derivatives show that L550 has a localized C14-C15 stretch at 1172 cm-1, consistent with a 14-s-trans chromophore. These results argue that the primary step in bacteriorhodopsin is a C13=C14 trans----cis photoisomerization that does not involve C14-C15 s-cis structures.

  10. FT-IR and FT-Raman spectra of 2-hydroxyethyl methacrylate--A conformational and vibrational analysis.

    PubMed

    Belaidi, O; Adjim, M; Bouchaour, T; Maschke, U

    2015-09-05

    A conformational search of the flexible 2-hedroxyethyl methacrylate molecule by semi-empirical AM1 and B3LYP formalisms leads to six stable conformations. Four of them are in the s-trans conformation. The optimized geometries at DFT using 6-311+G(∗∗) basis set are in good agreement with experimental electron diffraction data of the methyl methacrylate molecule, thereby the s-trans is the most stable form. The harmonic frequencies at the fully optimized geometries of all conformers have been performed at the DFT//B3LYP/6-311+G(∗∗) level of theory. Infrared and Raman intensities and potential energy distributions of the scaled harmonic frequencies are used for the assignment of the observed IR and Raman bands. We noticed a good agreement between the experimental and the computed spectra. The strong band at 1081 cm(-1), in the infrared spectrum, maybe used as a characteristic band of the s-trans conformation. Henceforth, the less stable structure contribute alone for reproducing the Raman bands located at 276 (sh) and 3020 (vw) cm(-1).

  11. What Are Normal Puberty, Precocious Puberty, and Delayed Puberty?

    MedlinePlus

    ... a long-lasting condition known as hypogonadism (pronounced HI-poe-GO-nad-iz-uhm ) in which the ... Turner syndrome or in individuals with hypogonadotropic (pronounced HI-po-GO-nah-doe-TROH-pik ) hypogonadism, which ...

  12. GC-->CG transversion mutation might be caused by 8-oxoguanine oxidation product.

    PubMed

    Kino, K; Sugiyama, H

    2000-01-01

    Oxidation of d(A6GGA6)/d(T6CCT6) with sensitizer under different UV irradiation periods was examined. Enzymatic digestion of photolysate revealed that the amount of 8-oxoG initially increased with decrease of G and then decreased with the formation of Iz. In order to investigate whether Iz was formed by one electron oxidation of 8-oxoG through long-range hole migration, photoirradiation of anthraquinone-linked oligomer was examined. The results clearly demonstrated that 8-oxoG was efficiently converted to Iz under irradiation conditions. These results suggest that Iz generated from 8-oxoG induces GC->CG transversion under oxidative condition.

  13. Imprinted zeolite modified carbon paste electrode as a potentiometric sensor for uric acid

    NASA Astrophysics Data System (ADS)

    Khasanah, Miratul; Widati, Alfa Akustia; Fitri, Sarita Aulia

    2016-03-01

    Imprinted zeolite modified carbon paste electrode (carbon paste-IZ) has been developed and applied to determine uric acid by potentiometry. The imprinted zeolite (IZ) was synthesized by the mole ratio of uric acid/Si of 0.0306. The modified electrode was manufactured by mass ratio of carbon, IZ and solid paraffin was 40:25:35. The modified electrode had shown the measurement range of 10-5 M to 10-2 M with Nernst factor of 28.6 mV/decade, the detection limit of 5.86 × 10-6 M and the accuracy of 95.3 - 105.0%. Response time of the electrode for uric acid 10-5 M - 10-2 M was 25 - 44 s. The developed electrode showed the high selectivity toward uric acid in the urea matrix. Life time of the carbon paste-IZ electrode was 10 weeks.

  14. Parallel Processing Applied to Computational Electromagnetics

    DTIC Science & Technology

    1991-10-01

    equations results, where N = NB + NW + NJ. IZ881 Wiz84’]II81 P [E81 1 EZW ] [ZWW] [ZW] [wl =[ [EWl (3-22) Iz’ rI [z’Wl IJ I [FI_ [E IJ where Z is the...was an array of four transputers on a motherboard that co . 1d be installed inside a PC. This decision was based on the low cost, ease of use, and

  15. Myofascial trigger points and innervation zone locations in upper trapezius muscles

    PubMed Central

    2013-01-01

    Background Myofascial trigger points (MTrPs) are hyperirritable spots located in taut bands of muscle fibres. Electrophysiological studies indicate that abnormal electrical activity is detectable near MTrPs. This phenomenon has been described as endplate noise and it has been purported to be associated MTrP pathophysiology. Thus, it is suggested that MTrPs will be overlap the innervation zone (IZ). The purpose of this work was to describe the location of MTrPs and the IZ in the right upper trapezius. Methods We screened 71 individuals and eventually enrolled 24 subjects with neck pain and active MTrPs and 24 neck pain-free subjects with latent MTrPs. Surface electromyography (sEMG) signals were detected using an electrode matrix during isometric contraction of the upper trapezius. A physiotherapist subsequently examined the subject’s trapezius to confirm the presence of MTrPs and establish their location. IZ locations were identified by visual analysis of sEMG signals. IZ and MTrPs locations were described using an anatomical coordinate system (ACS), with the skin area covered by the matrix divided into four quadrants. Results No significant difference was observed between active and latent MTrPs locations (P = 0.6). Forty-five MTrPs were in the third quadrant of the ACS, and 3 were included in second quadrant. IZs were located approximately midway between the seventh cervical vertebrae and the acromial angle in a limited area in the second and third quadrants. The mean distance between MTrP and IZ was 10.4 ± 5.8 mm. Conclusions According to the acquired results, we conclude that IZ and MTrPs are located in well-defined areas in upper trapezius muscle. Moreover, MTrPs in upper trapezius are proximally located to the IZ but not overlapped. PMID:23758854

  16. Microstructural Evolution of the Interdiffusion Zone between U-9 Wt Pct Mo Fuel Alloy and Zr-1 Wt Pct Nb Cladding Alloy Upon Annealing

    NASA Astrophysics Data System (ADS)

    Neogy, S.; Laik, A.; Saify, M. T.; Jha, S. K.; Srivastava, D.; Dey, G. K.

    2017-06-01

    Diffusion couple formed between U-9 wt pct Mo and Zr-1 wt pct Nb alloys, proposed as fuel and clad materials, respectively, in nuclear research reactors, was annealed to investigate the microstructural evolution of the interdiffusion zone (IZ) as a function of temperature. A layered-type IZ microstructure was observed, the mechanism of development of which was elucidated. Mo2Zr phase, present as dispersoids, in the U-rich part of the as-bonded IZ evolved into a continuous layer and into a "massive" morphology upon annealing. The discontinuous precipitation reaction in the matrix adjoining the Mo2Zr phase, instigated by Mo depletion, generated lamellae of α-U phase within the γ-U(Mo,Zr) matrix. Zr-rich α-Zr(U) precipitates were observed in U-rich U-Mo-Zr matrix in the IZ next to the U-9Mo base material due to the clustering tendency of the matrix phase. The IZ next to Zr-1Nb base material comprised a "basket weave" microstructure of α-Zr laths with β-Zr(Nb,U) interlath boundaries, wherein an omega like transformation of the latter to δ-UZr2 was also noticed. The growth rates of the IZ were orders of magnitude lower when compared with the ones reported between the compositionally similar U-10 wt pct Mo alloy and the presently used Al or Al-Si cladding alloys.

  17. Microstructural Evolution of the Interdiffusion Zone between U-9 Wt Pct Mo Fuel Alloy and Zr-1 Wt Pct Nb Cladding Alloy Upon Annealing

    NASA Astrophysics Data System (ADS)

    Neogy, S.; Laik, A.; Saify, M. T.; Jha, S. K.; Srivastava, D.; Dey, G. K.

    2017-03-01

    Diffusion couple formed between U-9 wt pct Mo and Zr-1 wt pct Nb alloys, proposed as fuel and clad materials, respectively, in nuclear research reactors, was annealed to investigate the microstructural evolution of the interdiffusion zone (IZ) as a function of temperature. A layered-type IZ microstructure was observed, the mechanism of development of which was elucidated. Mo2Zr phase, present as dispersoids, in the U-rich part of the as-bonded IZ evolved into a continuous layer and into a "massive" morphology upon annealing. The discontinuous precipitation reaction in the matrix adjoining the Mo2Zr phase, instigated by Mo depletion, generated lamellae of α-U phase within the γ-U(Mo,Zr) matrix. Zr-rich α-Zr(U) precipitates were observed in U-rich U-Mo-Zr matrix in the IZ next to the U-9Mo base material due to the clustering tendency of the matrix phase. The IZ next to Zr-1Nb base material comprised a "basket weave" microstructure of α-Zr laths with β-Zr(Nb,U) interlath boundaries, wherein an omega like transformation of the latter to δ-UZr2 was also noticed. The growth rates of the IZ were orders of magnitude lower when compared with the ones reported between the compositionally similar U-10 wt pct Mo alloy and the presently used Al or Al-Si cladding alloys.

  18. Relationship between innervation zone width and mean muscle fiber conduction velocity during a sustained isometric contraction

    PubMed Central

    Ye, X.; Beck, T.W.; Wages, N.P.

    2015-01-01

    Objectives: To examine the relationship between the biceps brachii muscle innervation zone (IZ) width and the mean muscle fiber conduction velocity (MFCV) during a sustained isometric contraction. Methods: Fifteen healthy men performed a sustained isometric elbow flexion exercise at their 60% maximal voluntary contraction (MVC) until they could not maintain the target force. Mean MFCV was estimated through multichannel surface electromyographic recordings from a linear electrode array. Before exercise, IZ width was quantified. Separate non-parametric one-way analyses of variance (ANOVAs) were used to examine whether there was a difference in each mean MFCV variable among groups with different IZ width. In addition, separate bivariate correlations were also performed to examine the relationships between the IZ width and the mean MFCV variables during the fatiguing exercise. Results: There was a significant difference in the percent decline of mean MFCV (%ΔMFCV) among groups with different IZ width (χ2 (3)=11.571, p=0.009). In addition, there was also a significant positive relationship between the IZ width and the %ΔMFCV (Kendall’s tau= 0.807; p<0.001). Conclusions: We believe that such relationship is likely influenced by both muscle fiber size and the muscle fiber type composition. PMID:25730657

  19. Accuracy of three different techniques for automatically estimating innervation zone location.

    PubMed

    Beck, Travis W; DeFreitas, Jason M; Stock, Matt S

    2012-01-01

    The purpose of this study was to compare the accuracy of the estimated innervation zone (IZ) locations obtained from cross-correlation, the minimum amplitude, and maximum center frequency criteria. Eight healthy men (mean±SD age=23.0±4.3 yrs) performed isometric muscle actions of the leg extensors, and 15 separate bipolar surface electromyographic (EMG) signals were detected from the vastus lateralis. A custom software program was used to estimate the location of the IZ based on: (1) the EMG channel that demonstrated the lowest amplitude, (2) the EMG channel that showed the highest mean frequency, and (3) the EMG channel that demonstrated the lowest peak cross-correlation between the signals from adjacent channels. The IZ location estimates from the lowest amplitude and highest mean frequency criteria were accurate in only 43.75% and 7.5% of the cases, respectively. The accuracy of the cross-correlation-based method was 90%. The cross-correlation-based method was much more accurate for estimating IZ location than were the lowest amplitude and highest mean frequency criteria. Cross-correlation could potentially be used for estimating the location of the IZ without the need for visual inspection of EMG signals.

  20. THREE-DIMENSIONAL INNERVATION ZONE IMAGING FROM MULTI-CHANNEL SURFACE EMG RECORDINGS

    PubMed Central

    LIU, YANG; NING, YONG; LI, SHENG; ZHOU, PING; RYMER, WILLIAM Z.; ZHANG, YINGCHUN

    2017-01-01

    There is an unmet need to accurately identify the locations of innervation zones (IZs) of spastic muscles, so as to guide botulinum toxin (BTX) injections for the best clinical outcome. A novel 3-dimensional IZ imaging (3DIZI) approach was developed by combining the bioelectrical source imaging and surface electromyogram (EMG) decomposition methods to image the 3D distribution of IZs in the target muscles. Surface IZ locations of motor units (MUs), identified from the bipolar map of their motor unit action potentials (MUAPs) were employed as a prior knowledge in the 3DIZI approach to improve its imaging accuracy. The performance of the 3DIZI approach was first optimized and evaluated via a series of designed computer simulations, and then validated with the intramuscular EMG data, together with simultaneously recorded 128-channel surface EMG data from the biceps of two subjects. Both simulation and experimental validation results demonstrate the high performance of the 3DIZI approach in accurately reconstructing the distributions of IZs and the dynamic propagation of internal muscle activities in the biceps from high-density surface EMG recordings. PMID:26160432

  1. Three-Dimensional Innervation Zone Imaging from Multi-Channel Surface EMG Recordings.

    PubMed

    Liu, Yang; Ning, Yong; Li, Sheng; Zhou, Ping; Rymer, William Z; Zhang, Yingchun

    2015-09-01

    There is an unmet need to accurately identify the locations of innervation zones (IZs) of spastic muscles, so as to guide botulinum toxin (BTX) injections for the best clinical outcome. A novel 3D IZ imaging (3DIZI) approach was developed by combining the bioelectrical source imaging and surface electromyogram (EMG) decomposition methods to image the 3D distribution of IZs in the target muscles. Surface IZ locations of motor units (MUs), identified from the bipolar map of their MU action potentials (MUAPs) were employed as a prior knowledge in the 3DIZI approach to improve its imaging accuracy. The performance of the 3DIZI approach was first optimized and evaluated via a series of designed computer simulations, and then validated with the intramuscular EMG data, together with simultaneously recorded 128-channel surface EMG data from the biceps of two subjects. Both simulation and experimental validation results demonstrate the high performance of the 3DIZI approach in accurately reconstructing the distributions of IZs and the dynamic propagation of internal muscle activities in the biceps from high-density surface EMG recordings.

  2. Innervation zones of the external anal sphincter in healthy male and female subjects. Preliminary results.

    PubMed

    Enck, P; Franz, H; Azpiroz, F; Fernandez-Fraga, X; Hinninghofen, H; Kaske-Bretag, K; Bottin, A; Martina, S; Merletti, R

    2004-01-01

    The objective of this work was to investigate the distribution of the innervation zones of the motor units that make up the external anal sphincter (EAS) in healthy males and females. A cylindrical probe carrying a circumferential array of 16 electrodes was used to detect the generation, propagation and extinction of individual motor unit action potentials (MUAPs) at 1, 2, and 3 cm depth from the orifice of the anal canal during maximal voluntary contractions of the EAS. Fifteen healthy males and 37 healthy nulliparous females were investigated. IZs could be detected in all males and in 34 out of 37 females. In the males, the IZs are scattered in the right and left hemisphincter at each of the three levels and their distribution is not affected by depth. In the females, the distribution is also concentrated in the right and left hemisphincter at depth 1 cm but is more uniform at depth 2 cm and more concentrated in the dorsal and ventral regions at depth 3 cm. ANOVA shows a statistically significant dependence of the IZ distribution on depth only in females and not in males. It is concluded that (a) IZs of the EAS can indeed be detected with a circumferential array placed at different depths along the anal canal; (b) large individual variability is observed, and (c) IZs show similar distribution at the three depth levels in males and different distributions in females. Copyright 2004 S. Karger AG, Basel

  3. Functional mapping of the pelvic floor and sphincter muscles from high-density surface EMG recordings.

    PubMed

    Peng, Yun; He, Jinbao; Khavari, Rose; Boone, Timothy B; Zhang, Yingchun

    2016-11-01

    Knowledge of the innervation of pelvic floor and sphincter muscles is of great importance to understanding the pathophysiology of female pelvic floor dysfunctions. This report presents our high-density intravaginal and intrarectal electromyography (EMG) probes and a comprehensive innervation zone (IZ) imaging technique based on high-density EMG readings to characterize the IZ distribution. Both intravaginal and intrarectal probes are covered with a high-density surface electromyography electrode grid (8 × 8). Surface EMG signals were acquired in ten healthy women performing maximum voluntary contractions of their pelvic floor. EMG decomposition was performed to separate motor-unit action potentials (MUAPs) and then localize their IZs. High-density surface EMG signals were successfully acquired over the vaginal and rectal surfaces. The propagation patterns of muscle activity were clearly visualized for multiple muscle groups of the pelvic floor and anal sphincter. During each contraction, up to 218 and 456 repetitions of motor units were detected by the vaginal and rectal probes, respectively. MUAPs were separated with their IZs identified at various orientations and depths. The proposed probes are capable of providing a comprehensive mapping of IZs of the pelvic floor and sphincter muscles. They can be employed as diagnostic and preventative tools in clinical practices.

  4. Noninvasive estimation of muscle fiber conduction velocity distribution using an electromyographic processing technique.

    PubMed

    Nishihara, Ken; Chiba, Yu; Moriyama, Hideki; Hosoda, Masataka; Suzuki, Yosuke; Gomi, Toshiaki

    2009-09-01

    Electromyography (EMG) is useful in investigating muscle activation; however, noninvasive evaluation of surface EMG is limited due to its complicated waveform. This study investigated muscle structure and activation using an analysis technique for surface EMG. Surface array electrodes were used in 17 healthy male subjects to record eight-channel EMGs from each biceps brachii muscle during voluntary isometric contraction with a 1-kg weight band with the subjects seated. The peaks detected by referenced EMGs were normalized and averaged as averaged pulses (APs) and the innervation zone (IZ) was estimated from the APs. Muscle fiber conduction velocities (MFCVs), estimated by the time difference of the peaks (method P) and by cross-correlation (method CC) by APs, were compared. Time periods with positive values around the central peak in AP (PP) were measured and the contribution of MFCVs by motor unit action potentials (MUAPs) was estimated. IZs were estimated in 12 subjects. Near the IZ, correlation between MFCVs by methods P and CC was lower than in other locations; MFCV was significantly larger by method P than by method CC in the vicinity of the IZ. PP of the comparison AP was significantly larger than that of the reference AP. The distribution of the MFCVs by different MUAPs was verified by computer simulation. Surface EMG was used to demonstrate the diversity of MFCVs, with some increased MFCVs, for several MUAPs in the vicinity of the IZ. This method could be applied to the evaluation of neuromuscular disorders.

  5. Study of the molecular structure, ionization spectrum, and electronic wave function of 1,3-butadiene using electron momentum spectroscopy and benchmark Dyson orbital theories

    NASA Astrophysics Data System (ADS)

    Deleuze, M. S.; Knippenberg, S.

    2006-09-01

    The scope of the present work is to reconcile electron momentum spectroscopy with elementary thermodynamics, and refute conclusions drawn by Saha et al. in J. Chem. Phys. 123, 124315 (2005) regarding fingerprints of the gauche conformational isomer of 1,3-butadiene in electron momentum distributions that were experimentally inferred from gas phase (e,2e) measurements on this compound [M. J. Brunger et al., J. Chem. Phys. 108, 1859 (1998)]. Our analysis is based on thorough calculations of one-electron and shake-up ionization spectra employing one-particle Green's function theory along with the benchmark third-order algebraic diagrammatic construction [ADC(3)] scheme. Accurate spherically averaged electron momentum distributions are correspondingly computed from the related Dyson orbitals. The ionization spectra and Dyson orbital momentum distributions that were computed for the trans-conformer of 1,3-butadiene alone are amply sufficient to quantitatively unravel the shape of all available experimental (e,2e) electron momentum distributions. A comparison of theoretical ADC(3) spectra for the s-trans and gauche energy minima with inner- and outer-valence high-resolution photoelectron measurements employing a synchrotron radiation beam [D. M. P. Holland et al., J. Phys. B 29, 3091 (1996)] demonstrates that the gauche structure is incompatible with ionization experiments in high-vacuum conditions and at standard temperatures. On the other hand, outer-valence Green's function calculations on the s-trans energy minimum form and approaching basis set completeness provide highly quantitative insights, within ˜0.2eV accuracy, into the available experimental one-electron ionization energies. At last, analysis of the angular dependence of relative (e,2e) ionization intensities nicely confirms the presence of one rather intense π-2 π*+1 satellite at ˜13.1eV in the ionization spectrum of the s-trans conformer.

  6. Exploring Chemical Bonds through Variations in Magnetic Shielding.

    PubMed

    Karadakov, Peter B; Horner, Kate E

    2016-02-09

    Differences in nuclear isotropic magnetic shieldings give rise to the chemical shifts measured in NMR experiments. In contrast to existing NMR experimental techniques, quantum chemical methods are capable of calculating isotropic magnetic shieldings not just at nuclei, but also at any point in the space surrounding a molecule. Using s-trans-1,3-butadiene, ethane, ethene, and ethyne as examples, we show that the variations in isotropic magnetic shielding around a molecule, represented as isosurfaces and contour plots, provide an unexpectedly clear picture of chemical bonding, which is much more detailed than the traditional description in terms of the total electron density.

  7. Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues.

    PubMed

    Roman, Bart I; Ryck, Tine De; Dierickx, Laura; Vanhoecke, Barbara W A; Katritzky, Alan R; Bracke, Marc; Stevens, Christian V

    2012-08-01

    In order to get a clearer view on the active geometry of anti-invasive chalcones, we have prepared a number of isoxazoles and related substances as conformationally restrained mimics of 1,3-diarylpropenones, and also of (Z)-stilbenes. In vitro anti-invasive activity data for 3,5-isoxazoles and 4,5-isoxazoles, together with an in silico geometrical comparison, point towards an active conformation for chalcones more resembling their s-trans geometry than the s-cis counterpart.

  8. 1,4-Bis(4-bromo-2,6-diisopropyl­phen­yl)-1,4-diaza­buta-1,3-diene

    PubMed Central

    Guzei, Ilia A.; Hill, Nicholas J.; Van Hout, Matthew R.

    2010-01-01

    The molecule of the title compound, C26H34Br2N2, lies on a crystallographic inversion center and hence the two imine groups are s-trans. The dihedral angle between the central 1,4-diaza­buta-1,3-diene unit and the attached substituted phenyl ring is 88.4 (7)°. The structure features a C—H⋯N close contact. The crystal selected for this study proved to be a non-merohedral twin with a minor component of 21.8 (3)%. PMID:21580146

  9. The (+)-cis- and (+)-trans-Olibanic Acids: Key Odorants of Frankincense.

    PubMed

    Cerutti-Delasalle, Céline; Mehiri, Mohamed; Cagliero, Cecilia; Rubiolo, Patrizia; Bicchi, Carlo; Meierhenrich, Uwe J; Baldovini, Nicolas

    2016-10-24

    Frankincense (olibanum) is one of the oldest aromatic materials used by humans, but the key molecular constituents contributing to its characteristic odor remained unknown. Reported herein is the discovery that (1S,2S)-(+)-trans- and (1S,2R)-(+)-cis-2-octylcyclopropyl-1-carboxylic acids are highly potent and substantive odorants occurring in ppm amounts in all of the frankincense samples analyzed, even those showing radically different volatile compositions. These cyclopropyl-derived acids provide the very characteristic old churchlike endnote of the frankincense odor. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Flutter and Time Response Analyses of Three Degree of Freedom Airfoils in Transonic Flow

    DTIC Science & Technology

    1981-08-01

    Reference 10), and a NACA 64A010 (Reference 4) airfoil. They also used STRANS2 and UTRANS2 to analyze a TF-8A wing section (Reference 4). In the...used for the reduced frequency kc with values up to 1.0 and the entire Mach number range. He used the code to study the NACA 64A010 airfoil for two...structural equation of motion. Rizzetta (Reference 1G) performed a time-response analysis of a NACA 64A010 airfoil with a single pitch d.o.f, and

  11. (E)-Methyl 2-benzyl-3-o-tolyl-acrylate.

    PubMed

    Karthikeyan, S; Sethusankar, K; Devaraj, Anthonisamy; Bakthadoss, Manickam

    2012-05-01

    In the title compound, C(18)H(18)O(2), the methyl acrylate substituent adopts an extended E conformation with all torsion angles close to 180°. The mean plane of the acrylate unit and the phenyl ring are approximately orthogonal to each other, making a dihedral angle of 81.40 (6)°. The position of the carbonyl group with respect to the olefinic double bond is typically S-trans. The crystal packing is stabilized by inter-molecular C-H⋯π inter-actions.

  12. Use of biomarkers in resident organisms as a tool for environmental monitoring in a cold coastal system, Tierra del Fuego Island.

    PubMed

    Comoglio, L; Amin, O; Botté, S; Marcovecchio, J

    2011-03-01

    Antioxidant status of Nacella (P) magellanica and Mytilus edulis related with heavy metal in sediment and tissues were analysed in five stations close to Ushuaia city in winter and spring. The principal component analysis produced a two-dimensional pattern of the degree of similarity between sites. The Industrial-Urban Contamination Index (IUCI) showed that the Industrial Zone (IZ) and Oil Marine Station (OMS) represent areas with anthropic inputs. Heavy metals have differential association with biomarkers depending on the species. In limpets, digestive gland presented major activities of enzyme defence in winter and gonads have shown higher values of Catalase (CAT) during spring while lipid peroxidation (LPO) presented higher values in IZ. For mussels CAT and LPO increased in spring time. For superoxide dismutase (SOD) peaks have been detected in IZ and NW stations for winter. Differences in biomarker responses due to seasons did not influence the grouping of the sites into references and contaminated groups.

  13. AlphaACT

    DTIC Science & Technology

    2014-07-20

    Evacuation centers Reset IZ and PAZ e El mm ^»i Ave Co Rd 172 w 6«h Av« @ w»t Figure 18 Buttons for setting key response...User Guide 1f«l<Viid::nUir,*T ^ufrti«< a’ Co^a^’wit Profvclr^* At::tion ZL R*t« IZ jwj PAZ .WM Wlnii Fatm 7^1* ktacMhm B»Jls^•ld -BugalMo CF«*II...Reset IZ and PAZ e ^ As^e Co Rd 172 W 64th Ave ® Meadowlalte West Figure 47 Buttons for setting key response locations on the

  14. Optimal Runge-Kutta Schemes for High-order Spatial and Temporal Discretizations

    DTIC Science & Technology

    2015-06-23

    tia l D is cr et iz at io ns – Te...se w ith hi gh -o rd er s pa tia l d is cr et iz at io ns 3 D is tr ib ut io n A – A pp ro ve d fo r p ub lic re le as e; D is tr ib ut io...or s fo r 5 th -o rd er sp at ia l s ch em es a re in ad eq ua te – Th e sa m e or de r o f s pa tia l a nd te m po ra l d is cr et iz

  15. Optimal Runge-Kutta Schemes for High-order Spatial and Temporal Discretizations

    DTIC Science & Technology

    2015-06-22

    tia l D is cr et iz at io ns – Te...se w ith hi gh -o rd er s pa tia l d is cr et iz at io ns 3 D is tr ib ut io n A – A pp ro ve d fo r p ub lic re le as e; D is tr ib ut io...or s fo r 5 th -o rd er sp at ia l s ch em es a re in ad eq ua te – Th e sa m e or de r o f s pa tia l a nd te m po ra l d is cr et iz

  16. Innervation zones of fasciculating motor units: observations by a linear electrode array.

    PubMed

    Jahanmiri-Nezhad, Faezeh; Barkhaus, Paul E; Rymer, William Z; Zhou, Ping

    2015-01-01

    This study examines the innervation zone (IZ) in the biceps brachii muscle in healthy subjects and those with amyotrophic lateral sclerosis (ALS) using a 20-channel linear electromyogram (EMG) electrode array. Raster plots of individual waveform potentials were studied to estimate the motor unit IZ. While this work mainly focused on fasciculation potentials (FPs), a limited number of motor unit potentials (MUPs) from voluntary activity of 12 healthy and seven ALS subjects were also examined. Abnormal propagation of MUPs and scattered IZs were observed in fasciculating units, compared with voluntarily activated MUPs in healthy and ALS subjects. These findings can be related to muscle fiber reinnervation following motor neuron degeneration in ALS and the different origin sites of FPs compared with voluntary MUPs.

  17. Angiotensin receptor blockade and angiotensin-converting-enzyme inhibition limit adverse remodeling of infarct zone collagens and global diastolic dysfunction during healing after reperfused ST-elevation myocardial infarction.

    PubMed

    Jugdutt, Bodh I; Idikio, Halliday; Uwiera, Richard R E

    2007-09-01

    To determine whether therapy with the angiotensin II type 1 receptor blocker (ARB) candesartan and the comparator angiotensin-converting-enzyme inhibitor (ACEI) enalapril during healing after reperfused ST-elevation myocardial infarction (RSTEMI) limit adverse remodeling of infarct zone (IZ) collagens and left ventricular (LV) diastolic dysfunction, we randomized 24 dogs surviving anterior RSTEMI (90-min coronary occlusion) to placebo, candesartan, and enalapril therapy between day 2 and 42. Six other dogs were sham. We measured regional IZ and non-infarct zone (NIZ) collagens (hydroxyproline; types I/III; cross-linking), transforming growth factor-beta (TGF-beta) and topography at 6 weeks, and hemodynamics, LV diastolic and systolic function, and remodeling over 6 weeks. Compared to sham, placebo-RSTEMI differentially altered regional collagens, with more pronounced increase in TGF-beta, hydroxyproline, and type I, insoluble, and cross-linked collagens in the IZ than NIZ, and increased IZ soluble and type III collagens at 6 weeks, and induced persistent LV filling pressure elevation, diastolic and systolic dysfunction, and LV remodeling over 6 weeks. Compared to placebo-RSTEMI, candesartan and enalapril limited adverse regional collagen remodeling, with normalization of type III, soluble and insoluble collagens and decrease in pyridinoline cross-linking in the IZ at 6 weeks, and attenuation of LV filling pressure, diastolic dysfunction, and remodeling over 6 weeks. The results suggest that candesartan and enalapril during healing after RSTEMI prevent rather than worsen adverse remodeling of IZ collagens and LV diastolic dysfunction, supporting the clinical use of ARBs and ACEIs during subacute RSTEMI.

  18. Flexural strength and failure modes of layered ceramic structures

    PubMed Central

    Borba, Márcia; de Araújo, Maico D.; de Lima, Erick; Yoshimura, Humberto N.; Cesar, Paulo F.; Griggs, Jason A.; Bona, Álvaro Della

    2011-01-01

    Objective to evaluate the effect of the specimen design on the flexural strength (σf) and failure mode of ceramic structures, testing the hypothesis that the ceramic material under tension controls the mechanical performance of the structure. Methods Three ceramics used as framework materials for fixed partial dentures (YZ - Vita In-Ceram YZ; IZ - Vita In-Ceram Zirconia; AL - Vita In-Ceram AL) and two veneering porcelains (VM7 and VM9) were studied. Bar-shaped specimens were produced in three different designs (n=10): monolithic, two layers (porcelain-framework) and three layers (TRI) (porcelain-framework-porcelain). Specimens were tested for three-point flexural strength at 1 MPa/s in 37°C artificial saliva. For bi-layered design, the specimens were tested in both conditions: with porcelain (PT) or framework ceramic (FT) layer under tension. Fracture surfaces were analyzed using stereomicroscope and scanning electron microscopy (SEM). Young’s modulus (E) and Poisson’s ratio (ν) were determined using ultrasonic pulse-echo method. Results were statistically analyzed by Kruskal-Wallis and Student-Newman-Keuls tests. Results Except for VM7 and VM9, significant differences were observed for E values among the materials. YZ showed the highest ν value followed by IZ and AL. YZ presented the highest σf. There was no statistical difference in the σf value between IZ and IZ-FT and between AL and AL-FT. σf values for YZ-PT, IZ-PT, IZ-TRI, AL-PT, AL-TRI were similar to the results obtained for VM7 and VM9. Two types of fracture mode were identified: total and partial failure. Significance The mechanical performance of the specimens was determined by the material under tension during testing, confirming the study hypothesis. PMID:21982199

  19. Continuous desulfurization and bacterial community structure of an integrated bioreactor developed to treat SO2 from a gas stream.

    PubMed

    Lin, Jian; Li, Lin; Ding, Wenjie; Zhang, Jingying; Liu, Junxin

    2015-11-01

    Sulfide dioxide (SO2) is often released during the combustion processes of fossil fuels. An integrated bioreactor with two sections, namely, a suspended zone (SZ) and immobilized zone (IZ), was applied to treat SO2 for 6months. Sampling ports were set in both sections to investigate the performance and microbial characteristics of the integrated bioreactor. SO2 was effectively removed by the synergistic effect of the SZ and IZ, and more than 85% removal efficiency was achieved at steady state. The average elimination capacity of SO2 in the bioreactor was 2.80g/(m(3)·hr) for the SZ and 1.50g/(m(3)·hr) for the IZ. Most SO2 was eliminated in the SZ. The liquid level of the SZ and the water content ratio of the packing material in the IZ affected SO2 removal efficiency. The SZ served a key function not only in SO2 elimination, but also in moisture maintenance for the IZ. The desired water content in IZ could be feasibly maintained without any additional pre-humidification facilities. Clone libraries of 16S rDNA directly amplified from the DNA of each sample were constructed and sequenced to analyze the community composition and diversity in the individual zones. The desulfurization bacteria dominated both zones. Paenibacillus sp. was present in both zones, whereas Ralstonia sp. existed only in the SZ. The transfer of SO2 to the SZ involved dissolution in the nutrient solution and biodegradation by the sulfur-oxidizing bacteria. This work presents a potential biological treatment method for waste gases containing hydrophilic compounds. Copyright © 2015. Published by Elsevier B.V.

  20. A Mathematical Model of the Human Small Intestine Following Acute Radiation and Burn Exposures

    DTIC Science & Technology

    2016-08-01

    C kg–1) absorbed dose ( rad ) 1 × 10–2 joule per kilogram (J kg–1§) equivalent and effective dose (rem) 1 × 10–2 joule per kilogram (J kg–1...burn (days) C ry pt c el ls p er c ol um n (n or m al iz ed ) ● Duodenum Ileum Burn (16% TBSA) ● 0 1 2 3 0 1 2 3 4 Time after rad (days) C ry pt... c el ls p er c ol um n (n or m al iz ed ) ● Duodenum Ileum Rad (7 Gy) ● 0 1 2

  1. Contact Analysis of Nominally Flat Surfaces

    DTIC Science & Technology

    2008-06-01

    researchers, Abdo and Farhang [7]. The work began with a literature survey which discussed the work of Greenwood and Williamson and the downfalls of Hertz...Electrical Conductivity γ N or m al iz ed E le ct ric al C on du ct iv ity 1.3 1.4 1.5 1.7 1.9 0.9 1 1.1 1.2 Temperature γ N or m al iz ed T em pe...40 (21 July 2007), pp. 4245-4252. [7] J. Abdo and K. Farhang, “Elastic-Plastic Contact Model for Rough Surfaces Based on Plastic Asperity

  2. Detection of Multiple Innervation Zones from Multi-Channel Surface EMG Recordings with Low Signal-to-Noise Ratio Using Graph-Cut Segmentation

    PubMed Central

    Farahi, Morteza; Rojas, Monica; Mañanas, Miguel Angel; Farina, Dario

    2016-01-01

    Knowledge of the location of muscle Innervation Zones (IZs) is important in many applications, e.g. for minimizing the quantity of injected botulinum toxin for the treatment of spasticity or for deciding on the type of episiotomy during child delivery. Surface EMG (sEMG) can be noninvasively recorded to assess physiological and morphological characteristics of contracting muscles. However, it is not often possible to record signals of high quality. Moreover, muscles could have multiple IZs, which should all be identified. We designed a fully-automatic algorithm based on the enhanced image Graph-Cut segmentation and morphological image processing methods to identify up to five IZs in 60-ms intervals of very-low to moderate quality sEMG signal detected with multi-channel electrodes (20 bipolar channels with Inter Electrode Distance (IED) of 5 mm). An anisotropic multilayered cylinder model was used to simulate 750 sEMG signals with signal-to-noise ratio ranging from -5 to 15 dB (using Gaussian noise) and in each 60-ms signal frame, 1 to 5 IZs were included. The micro- and macro- averaged performance indices were then reported for the proposed IZ detection algorithm. In the micro-averaging procedure, the number of True Positives, False Positives and False Negatives in each frame were summed up to generate cumulative measures. In the macro-averaging, on the other hand, precision and recall were calculated for each frame and their averages are used to determine F1-score. Overall, the micro (macro)-averaged sensitivity, precision and F1-score of the algorithm for IZ channel identification were 82.7% (87.5%), 92.9% (94.0%) and 87.5% (90.6%), respectively. For the correctly identified IZ locations, the average bias error was of 0.02±0.10 IED ratio. Also, the average absolute conduction velocity estimation error was 0.41±0.40 m/s for such frames. The sensitivity analysis including increasing IED and reducing interpolation coefficient for time samples was performed

  3. Identification of Tumor Rejection Antigens for Breast Cancer Using a Mouse Tumor Rejection Model

    DTIC Science & Technology

    2008-05-01

    Days after Tumor Implantation Tu m or S iz e (m m 3 ) 0 10 20 30 40 0 1000 2000 3000 PBS MMC Swap70...or Gsn, or irradiated whole tumor cells at day -42, -28, and -14. Live MMC cells were given subcutaneously on day 0. 0 10 20 30 40...hICD Mtv1 Mtv1 + FxyD3 Mtv1 + FxyD3 + hICD Days after MMC chalange Tu m or s iz e( m m 3) Figure 4. Multi-antigen vaccines

  4. Spectrally-Temporally Adapted Spectrally Modulated Spectrally Encoded (SMSE) Waveform Design for Coexistent CR-Based SDR Applications

    DTIC Science & Technology

    2010-03-01

    Faculty Graduate School of Engineering and Management Air Force Institute of Technology Air University Air Education and Training Command in Partial...the time and opportunity to continue my education , and the Laboratory for Telecommunica- tions Sciences for sponsoring this research. Eric C. Like vi...the ktℎ SMSE symbol according to sk[m] = NP−1∑ i=0 N ik−1∑ z=0 di, zk a i m,ku i,z m,kc i,z m,kwme jΘi,z m,k , (3.21) Θi,zm,k = ci,zm,k + di, zk + wm

  5. Investigations of Surface Roughness Effects on Turbulent Flow and Heat Transfer

    DTIC Science & Technology

    1990-10-01

    tearing ...E 00 U, .d o) C oS Lo 0A0 00 0 0 C0A E 000o000 0 000 4-) C’, 180 _ _ _ _ _ _ _ _ _ _ _ 0 -2 w Iz - m) 0 in ’I % a EE OAn AC OA 0 0 A A CA. CA 0 .u...000 0 0 00 4-I U, 189 00 & 0 0A & 0~ CA) co IGHAa a C; CA C;D CA 1900 w Iz OA w w OA WWa OA z0 CJ) 41 a 0 2 iicis 0 mwNwIn IV m cu 00o0 000 0 0 0

  6. Infrared spectra of molecules and materials of astrophysical interest

    NASA Technical Reports Server (NTRS)

    Durig, J. R.

    1978-01-01

    The Raman spectra of gaseous, liquid and solid, and infrared spectra of gaseous and solid isopropylamine-d sub 0 and -d sub 2 was investigated between 4000 and 50 cm superscript -1. Differences between the spectrum of the solid phase and that of the fluid phases were interpreted in terms of an equilibrium between low energy s-trans and high energy gauche conformers, and a complete vibrational assignment was proposed for the s-trans conformer. The far infrared spectra of the gaseous compounds contained bands due to the asymmetric amino and coupled methyl torsions; the assignment of these bands was aided by observation of a number of two quantum transitions for each vibrational mode. The asymmetric potential functions were calculated, which resulted in values for the enthalpy differences between conformers in the gaseous phase of 446 and 523 callmole for the sub 0 -d and -d sub 2 compounds, respectively. The methyl torsional potential function of isopropylamine-d sub 0 was calculated which led to a value for the barrier height to internal rotation of the methyl rotors of 4.23 + or - 0.06 kcal/mole. Values for the ideal gas thermodynamic functions were calculated over a range of temperatures.

  7. X-ray crystal structure and time-resolved spectroscopy of the blue carotenoid violerythrin.

    PubMed

    Polívka, Tomás; Frank, Harry A; Enriquez, Miriam M; Niedzwiedzki, Dariusz M; Liaaen-Jensen, Synnøve; Hemming, Joanna; Helliwell, John R; Helliwell, Madeleine

    2010-07-08

    Violerythrin, a blue-colored carotenoid, has been investigated by X-ray crystallography and steady-state and ultrafast time-resolved absorption spectroscopy. The X-ray crystal structure of violerythrin shows that the molecule is nearly planar with the terminal rings positioned in the s-trans conformation. The steady-state and time-resolved spectroscopic data of violerythrin do not differ significantly from those of other carbonyl carotenoids with long (N > 10) pi-electron conjugated chains. This indicates that while the four carbonyl groups in violerythrin are critical for generating the bathochromic shift that leads to the blue color of the molecule, no dramatic changes attributable to a charge-transfer state known to affect the excited-state properties of carotenoids with short polyene chains occur. This may be due to the symmetric distribution of the carbonyl groups, which would preclude such an effect. The structural requirements for a blue, neutral, carotenoid are a planar, symmetric, cross-conjugated chromophore, containing at least 30 pi-electrons, a central polyene chain with 9 or 10 conjugated carbon-carbon double bonds connected at each end by an s-trans or trans bond to two identical, cyclic end groups, each possessing a conjugated keto group further cross-conjugated to another keto group, or a double bond in a quinoid type structure.

  8. Conformational properties, torsional potential, and vibrational force field for methacryloyl fluoride - An ab initio investigation

    NASA Technical Reports Server (NTRS)

    Laskowski, B. C.; Jaffe, R. L.; Komornicki, A.

    1985-01-01

    The structure, torsional potentials, vibrational spectra, and harmonic force fields for s-cis and s-trans isomers of methacryloyl fluoride are examined to understand the conformational properties of the molecules and their relationship to macroscopic polymer properties. The structure is found to be in good agreement with experiment. It is shown by calculations that the energy difference between the cis and the transisomers is less than 1 kcal/mol at both the split valence and the split valence polarized levels, with the trans form favored. Analysis of the torsional potentials indicates that a rigid rotor model provides a reasonable description of the motion of the COF group in the molecule. The torsional barrier to interconvert the s-trans to the s-cis form is found to be 7.0 kcal/mol. A fit of the data to a three-term Fourier series shows that it is possible to reproduce the experimentally derived barrier, even though a direct determination indicates that the barrier is higher.

  9. Enantioselective kappa opioid binding sites on the macrophage cell line, P388d sub 1

    SciTech Connect

    Carr, D.J.J.; Blalock, J.E. ); DeCosta, B.R.; Jacobson, A.E.; Rice, K.C. )

    1991-01-01

    A kappa opioid binding site has been characterized on the macrophage cell line, P388d{sub 1}, using the kappa selective affinity ligand, ({sup 3H}(1S,2S)-(-)-trans-2-isothiocyanato-N-methyl-N-(2-(1-phrrolidinyl) cyclohexyl) benzeneacetamide ((-)BD166). The kappa site has a relative molecular mass (Mr) of 38,000 under nonreducing conditions and 42,000 under reducing conditions. Moreover, it exhibits enantioselectivity in that 1S,2S-(-)-trans-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl) benzeneacetamide ((-)-U-50,488) blocks ({sup 3}H)95{alpha},7{alpha},8{beta})-(-)-N-methyl-N-(7-(1- pyrrolidinyl)-1-oxaspiro-(4,5)-dec-8-yl)benzeneacetamide (U-69,593) binding to P388d{sub 1} cells with an IC{sub 50} = 7.0 nM whereas 1R,2R-(+)-trans-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl) benzeneacetamide ((+)U-50,488) blocks ({sup 3}H)U-69,593 binding to P388d{sub 1} cells with an IC{sub 50} = 700 nM.

  10. Reaction pathways by quantum Monte Carlo: insight on the torsion barrier of 1,3-butadiene, and the conrotatory ring opening of cyclobutene.

    PubMed

    Barborini, Matteo; Guidoni, Leonardo

    2012-12-14

    Quantum Monte Carlo (QMC) methods are used to investigate the intramolecular reaction pathways of 1,3-butadiene. The ground state geometries of the three conformers s-trans, s-cis, and gauche, as well as the cyclobutene structure are fully optimised at the variational Monte Carlo (VMC) level, obtaining an excellent agreement with the experimental results and other quantum chemistry high level calculations. Transition state geometries are also estimated at the VMC level for the s-trans to gauche torsion barrier of 1,3-butadiene and for the conrotatory ring opening of cyclobutene to the gauche-1,3-butadiene conformer. The energies of the conformers and the reaction barriers are calculated at both variational and diffusional Monte Carlo levels providing a precise picture of the potential energy surface of 1,3-butadiene and supporting one of the two model profiles recently obtained by Raman spectroscopy [Boopalachandran et al., J. Phys. Chem. A 115, 8920 (2011)]. Considering the good scaling of QMC techniques with the system's size, our results also demonstrate how variational Monte Carlo calculations can be applied in the future to properly investigate the reaction pathways of large and correlated molecular systems.

  11. Conformational properties, torsional potential, and vibrational force field for methacryloyl fluoride - An ab initio investigation

    NASA Technical Reports Server (NTRS)

    Laskowski, B. C.; Jaffe, R. L.; Komornicki, A.

    1985-01-01

    The structure, torsional potentials, vibrational spectra, and harmonic force fields for s-cis and s-trans isomers of methacryloyl fluoride are examined to understand the conformational properties of the molecules and their relationship to macroscopic polymer properties. The structure is found to be in good agreement with experiment. It is shown by calculations that the energy difference between the cis and the transisomers is less than 1 kcal/mol at both the split valence and the split valence polarized levels, with the trans form favored. Analysis of the torsional potentials indicates that a rigid rotor model provides a reasonable description of the motion of the COF group in the molecule. The torsional barrier to interconvert the s-trans to the s-cis form is found to be 7.0 kcal/mol. A fit of the data to a three-term Fourier series shows that it is possible to reproduce the experimentally derived barrier, even though a direct determination indicates that the barrier is higher.

  12. Branch Point Mitigation of Thermal Blooming Phase Compensation Instability

    DTIC Science & Technology

    2011-03-01

    coefficient  z is accounted for with a path integral over the user-defined partial propagation distance 1i iz z z   . Known as Beers ’ law, Eq. (49...the thicker the brew the less that gets through‖). As seen in Figure 4, the transmittance for a particular engagement scenario with a propagation

  13. "Educación Bilingüe a Nivel De Escuela Secundaria": Dual-Language Education at the High School Level

    ERIC Educational Resources Information Center

    Vazquez, Dania

    2013-01-01

    The Summer 2013 issue of "Voices in Urban Education" presents an interview with Dania Vazquez, founding principal of the Margarita Muñiz Academy, a Boston public high school offering dual-language education in Spanish and English. The first dual-language high school in Massachusetts, this Innovation School opened in the fall of 2012 with…

  14. Training and Organization of the US Army Reserve Components: A Reference Text for Total Trainers, 1986-1987.

    DTIC Science & Technology

    1987-03-15

    trained individual reservists and retired personnel to enable the Army to successfully wage war. c. Administer the USAR Active Guard/Reserve (AGR) and...tna lir iz trainin] :rogrim far aircrews of both the Air Force an] Air be ; ve, irTes. T’e, r,9 llti n:] .xpre] the minimun training requirements in

  15. A Simple and Reliable Vacuum Seal for Optical Windows

    DTIC Science & Technology

    1988-01-01

    Journa.1 of Applied Spectroscopy January 1988 Issue COSATI CODES 18. SUBJECT TERMS (Continue on reverse if necessary and identify by block number...1988 M13 -0sfhz i ,.. . APPLIED SPECTROSCOPY 181 1 , .,.trv -,,,-u - . .... ..- ’ ,CELL BODY (F) CELL COY ;%: IZ 6 0 --RING (E) " 0RN E.,L b t

  16. A Study of Pilots’ Value Systems and Their Effect on Career Intentions

    DTIC Science & Technology

    1978-09-01

    ness, and goodness (11:IZ5-6). Knowledge of value systems comnplt. .ents Maslow’s hierarchy of needs . The value system is an organization of learned...can be related to Maslow’s hierarchy of needs . The question thus arises as to how value.N affect the everyday adult life. How Values Influence Behavior

  17. Immunization information systems--progress on integration of school nurses: a multi-state roundtable.

    PubMed

    Galemore, Cynthia A

    2011-03-01

    The following is an article and roundtable discussion on school nurse integration into immunization information systems. The discussion participants were April Bailey, Deputy Director, Immunization Division, Indiana State Department of Health; Thomas Maerz, Manager, Wisconsin Immunization Registry; Erin Seward, Immunization Program Manager, Nevada State Health Division; and Debra Warren, Project Manager, KSWebIZ, Kansas Immunization Program.

  18. Development of a Fire-Resistant Anti-Sweat Submarine Hull Insulation Based on Fiber Glass Materials.

    DTIC Science & Technology

    1983-09-01

    CHART NATIONAL BUREAU OF STANDARDS-1963-A6w " ;’’ ..J’ d’ ,.,, -,,,.. ,.- -,. . 11111, , .. b,, I - - -.. .,. , .. . ..°.. III. . . ,Lm’ Johns ... Manville Research & Development Center DEVELOPMENT OF A FIRE-RESISTANT ANTI-SWEAT SUBMARINE HULL INSULATION BASED ON FIBER *" GLASS MATERIALS Oct icrb iz Ic

  19. The influence of electromyographic recording methods and the innervation zone on the mean power frequency-torque relationships.

    PubMed

    Herda, Trent J; Zuniga, Jorge M; Ryan, Eric D; Camic, Clayton L; Bergstrom, Haley C; Smith, Doug B; Weir, Joseph P; Cramer, Joel T; Housh, Terry J

    2015-06-01

    This study examined the effects of electromyographic (EMG) recording methods and innervation zone (IZ) on the mean power frequency (MPF)-torque relationships. Nine subjects performed isometric ramp muscle actions of the leg extensors from 5% to 100% of maximal voluntary contraction with an eight channel linear electrode array over the IZ of the vastus lateralis. The slopes were calculated from the log-transformed monopolar and bipolar EMG MPF-torque relationships for each channel and subject and 95% confidence intervals (CI) were constructed around the slopes for each relationship and the composite of the slopes. Twenty-two to 55% of the subjects exhibited 95% CIs that did not include a slope of zero for the monopolar EMG MPF-torque relationships while 25-75% of the subjects exhibited 95% CIs that did not include a slope of zero for the bipolar EMG MPF-torque relationships. The composite of the slopes from the EMG MPF-torque relationships were not significantly different from zero for any method or channel, however, the method and IZ location slightly influenced the number of significant slopes on a subject-by-subject basis. The log-transform model indicated that EMG MPF-torque patterns were nonlinear regardless of recording method or distance from the IZ.

  20. The Functionator 3000: Transforming Numbers and Children

    ERIC Educational Resources Information Center

    Fisher, Elaine Cerrato; Roy, George; Reeves, Charles

    2013-01-01

    Mrs. Fisher's class was learning about arithmetic functions by pretending to operate real-world "function machines" (Reeves 2006). Functions are a unifying mathematics topic, and a great deal of emphasis is placed on understanding them in prekindergarten through grade 12 (Kilpatrick and Izsák 2008). In its Algebra Content Standard, the…

  1. The Functionator 3000: Transforming Numbers and Children

    ERIC Educational Resources Information Center

    Fisher, Elaine Cerrato; Roy, George; Reeves, Charles

    2013-01-01

    Mrs. Fisher's class was learning about arithmetic functions by pretending to operate real-world "function machines" (Reeves 2006). Functions are a unifying mathematics topic, and a great deal of emphasis is placed on understanding them in prekindergarten through grade 12 (Kilpatrick and Izsák 2008). In its Algebra Content Standard, the…

  2. The role of infarct transmural extent in infarct extension: A computational study.

    PubMed

    Leong, Chin-Neng; Lim, Einly; Andriyana, Andri; Al Abed, Amr; Lovell, Nigel Hamilton; Hayward, Christopher; Hamilton-Craig, Christian; Dokos, Socrates

    2017-02-01

    Infarct extension, a process involving progressive extension of the infarct zone (IZ) into the normally perfused border zone (BZ), leads to continuous degradation of the myocardial function and adverse remodelling. Despite carrying a high risk of mortality, detailed understanding of the mechanisms leading to BZ hypoxia and infarct extension remains unexplored. In the present study, we developed a 3D truncated ellipsoidal left ventricular model incorporating realistic electromechanical properties and fibre orientation to examine the mechanical interaction among the remote, infarct and BZs in the presence of varying infarct transmural extent (TME). Localized highly abnormal systolic fibre stress was observed at the BZ, owing to the simultaneous presence of moderately increased stiffness and fibre strain at this region, caused by the mechanical tethering effect imposed by the overstretched IZ. Our simulations also demonstrated the greatest tethering effect and stress in BZ regions with fibre direction tangential to the BZ-remote zone boundary. This can be explained by the lower stiffness in the cross-fibre direction, which gave rise to a greater stretching of the IZ in this direction. The average fibre strain of the IZ, as well as the maximum stress in the sub-endocardial layer, increased steeply from 10% to 50% infarct TME, and slower thereafter. Based on our stress-strain loop analysis, we found impairment in the myocardial energy efficiency and elevated energy expenditure with increasing infarct TME, which we believe to place the BZ at further risk of hypoxia. Copyright © 2016 John Wiley & Sons, Ltd.

  3. Vibration Experiments

    DTIC Science & Technology

    1963-12-01

    SUSPENSION FORCES = MASS X ACCELERATION Fgz W- VSCZZ + Ni = m (-i + ) ROLL: GUN MOMENT + GROUND FRICTIONAL MOMENT + SUSPENSIONAL MOMENT = ANGULAR...FRICTIONAL MOMENT - SUSPENSIONAL MOMENT = ANGULAR ACCELERATION X MOMENT OF INERTIA - RFaz + !Fgx - (z + z0) FfxCxX - n Nixi = ay~y + Oxix (Ix - Iz) + a2 )i1l

  4. Information Distribution in Complex Systems to Improve Team Performance

    DTIC Science & Technology

    2006-01-01

    C’ ccf--- _ C’CU M , -- Cý " V D 0E - -2~ 0~ E *:- Z, S~- M2C CD , V - k.C’ 0 C)t ’ -~~~~t M’ Iz-C~C)X ~ ) ) C 0 oo >, ’r 0) CN C) C- 0, Q~ C-4, L L

  5. Illinois' Early Childhood Innovation Zones: A New Model for State Policy? IERC 2017-1

    ERIC Educational Resources Information Center

    White, Bradford R.; Colaninno, Carol E.; Doll, Mimi; Lewandowski, Holly

    2017-01-01

    This report is an evaluation of efforts made by Illinois Action for Children (IAFC), with oversight from the Illinois Governor's Office for Early Childhood Development (OECD), to test, support, and facilitate innovations in the early childhood system in 11 communities across the state. The Early Childhood Innovation Zones (IZ) initiative, funded…

  6. Mapping of Hot/Cold Springs in a Large Lake Using Thermal Remote Sensing and In-situ Measurement

    NASA Astrophysics Data System (ADS)

    Gurcan, T.; Kurtulus, B.; Avşar

    2016-12-01

    In this study, in-situ measurement and thermal infrared imagery was used to map hot and cold springs of Köyceǧiz Lake in Turkey, which is one of the biggest open coastal lakes in the world. In-situ surface, depth water temperature, climatic data and bathymetry measurement were collected using data loggers. Landsat 8 TIRS Band 10 (Thermal Infrared Sensors) images were compared with in-situ measurements. Electrical conductivity, pH and salinity measurement were also collected at the bottom of the lake to better understand the groundwater discharge evidence in the lake. In-situ measurement were interpolated using Empirical Bayesian Kriging (EBK). In-Situ measurement and Landsat 8 Images were compared pixel by pixel and appropriate regression equation were calculated according to best coefficient of correlation (R2). The results show that in-situ measurement of temperature at surface of the Köyceǧiz Lake has a good correlation for several cases (R2 ≥ 0.7) with Landsat 8 TIR images (Figure1). The mapping results of in-situ measurements also reveal that at the north east part of the Köyceǧiz Lake there exist several evidence of cold spring at the bottom of the Lake. Hot spring evidence were located at the South-West part of the Köyceǧiz Lake near the Sultaniye region. In this regard, we would like to thank TUBITAK project (112Y137) for their financial support.

  7. THE CHILD'S KNOWLEDGE OF ENGLISH PLURALIZATION RULES.

    ERIC Educational Resources Information Center

    ANISFELD, MOSHE

    THIS PAPER PRESENTS FIRST A SUMMARY OF RESEARCH INVESTIGATING THE EXTENT TO WHICH THE KINDERGARTEN CHILD HAS ABSTRACTED IMPLICIT REGULARITIES IN THE FORMATION OF PLURALS IN ENGLISH. PRODUCTION AND RECOGNITION TASKS WERE USED. THE CHILDREN MADE MORE ERRORS WITH SYLLABLES REQUIRING THE ADDITION OR DELETION OF THE /IZ/ ALLOMORPH THAN WITH SYLLABLES…

  8. Redundancy Analysis and a Distributed Self-Organization Protocol for Fault-Tolerant Wireless Sensor Networks

    DTIC Science & Technology

    2007-07-01

    Europe (DATE) Conference. He is also a recipient of the Humboldt Research Fellowship, awarded by the Alexander von Humboldt Foundation, Germany, and the...in FTNS for FT nodes selection. 150 200 250 300 350 400 600 800 1000 1200 1400 1600 Total Number of Nodes S en di ng D at a S iz e (B yt es ) (i

  9. Cohesion: A New Perspective.

    DTIC Science & Technology

    1983-06-01

    22, 27 July 1982. .I I-Z 130 *1 > ; : . . . . . .. . . .. ... . . . : . .. ; . . . BIBLIOGRAPHY Askenasy , A.R., Perception of Korean Opinions: A...BIBLIOGRAPHY Askenasy , A.R., Perception of Korean Opinions: A Study of U.S. Officer’s Expertise, American University Center for Research in Social

  10. Hardware complications and failure of three-unit zirconia-based and porcelain-fused-metal implant-supported fixed dental prostheses: a retrospective cohort study with up to 8 years.

    PubMed

    Shi, Jun-Yu; Zhang, Xiao-Meng; Qiao, Shi-Chong; Qian, Shu-Jiao; Mo, Jia-Ji; Lai, Hong-Chang

    2017-05-01

    The aim of the present study was to assess the hardware complications and survival of three-unit implant-supported zirconia-based fixed dental prostheses (IZ) and implant-supported porcelain-fused-metal fixed dental prostheses (IP). The study is a retrospective cohort study with up to 8 years (mean 4.8 years) follow-up. Patients with conventional three-unit implant-supported fixed dental prostheses (without cantilever) in posterior area were reviewed. Hardware complications and survival rate were evaluated. Chi-Square test was used to test the difference between IZ and IP groups. Two hundred and thirty-seven patents (IZ : 112, IP : 125) with 279 three-unit restorations (IZ : 127, IP : 152) participated in the study. The overall survival rate was 95.3% in IZ group and 94.7% in IP group at implant-level and 94.6% in IZ group and 94.4% in IP group at subject-level. Veneer chipping was the most frequently seen complication (20.1%). Significant higher minor veneer chipping rate (Grade 1) was found in IZ group (P = 0.04). No significant difference of veneer chipping rate (Grade 2 and Grade 3) was found between the two groups. The overall hardware complication rates of IZ were significantly higher than IP (33.07% and 18.42%, P = 0.01). High survival rate of zirconia-base and Porcelain-fused-to-metal (PFM) restorations can be achieved with up to 8 years follow-up. The zirconia-based restorations need more polishing procedures, maintenance, and professional care than PFM restorations. The number of implants supporting a fixed dental prosthesis did not influence the implant survival and hardware complications. Well-designed studies with high evidence level are still needed to further explore the hardware complications and clinical survival of IZ and IP. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Toroidal high-spin isomers in the nucleus 304120

    NASA Astrophysics Data System (ADS)

    Staszczak, A.; Wong, Cheuk-Yin; Kosior, A.

    2017-05-01

    Background: Strongly deformed oblate superheavy nuclei form an intriguing region where the toroidal nuclear structures may bifurcate from the oblate spheroidal shape. The bifurcation may be facilitated when the nucleus is endowed with a large angular moment about the symmetry axis with I =Iz . The toroidal high-K isomeric states at their local energy minima can be theoretically predicted using the cranked self-consistent Skyrme-Hartree-Fock method. Purpose: We use the cranked Skyrme-Hartree-Fock method to predict the properties of the toroidal high-spin isomers in the superheavy nucleus 120304184. Method: Our method consists of three steps: First, we use the deformation-constrained Skyrme-Hartree-Fock-Bogoliubov approach to search for the nuclear density distributions with toroidal shapes. Next, using these toroidal distributions as starting configurations, we apply an additional cranking constraint of a large angular momentum I =Iz about the symmetry z axis and search for the energy minima of the system as a function of the deformation. In the last step, if a local energy minimum with I =Iz is found, we perform at this point the cranked symmetry- and deformation-unconstrained Skyrme-Hartree-Fock calculations to locate a stable toroidal high-spin isomeric state in free convergence. Results: We have theoretically located two toroidal high-spin isomeric states of 120304184 with an angular momentum I =Iz=81 ℏ (proton 2p-2h, neutron 4p-4h excitation) and I =Iz=208 ℏ (proton 5p-5h, neutron 8p-8h) at the quadrupole moment deformations Q20=-297.7 b and Q20=-300.8 b with energies 79.2 and 101.6 MeV above the spherical ground state, respectively. The nuclear density distributions of the toroidal high-spin isomers 120304184(Iz=81 ℏ and 208 ℏ ) have the maximum density close to the nuclear matter density, 0.16 fm-3, and a torus major to minor radius aspect ratio R /d =3.25 . Conclusions: We demonstrate that aligned angular momenta of Iz=81 ℏ and 208 ℏ arising from

  12. Simultaneous Intracranial EEG-fMRI Shows Inter-Modality Correlation in Time-Resolved Connectivity Within Normal Areas but Not Within Epileptic Regions.

    PubMed

    Ridley, Ben; Wirsich, Jonathan; Bettus, Gaelle; Rodionov, Roman; Murta, Teresa; Chaudhary, Umair; Carmichael, David; Thornton, Rachel; Vulliemoz, Serge; McEvoy, Andrew; Wendling, Fabrice; Bartolomei, Fabrice; Ranjeva, Jean-Philippe; Lemieux, Louis; Guye, Maxime

    2017-02-13

    For the first time in research in humans, we used simultaneous icEEG-fMRI to examine the link between connectivity in haemodynamic signals during the resting-state (rs) and connectivity derived from electrophysiological activity in terms of the inter-modal connectivity correlation (IMCC). We quantified IMCC in nine patients with drug-resistant epilepsy (i) within brain networks in 'healthy' non-involved cortical zones (NIZ) and (ii) within brain networks involved in generating seizures and interictal spikes (IZ1) or solely spikes (IZ2). Functional connectivity (h (2) ) estimates for 10 min of resting-state data were obtained between each pair of electrodes within each clinical zone for both icEEG and fMRI. A sliding window approach allowed us to quantify the variability over time of h (2) (vh (2)) as an indicator of connectivity dynamics. We observe significant positive IMCC for h (2) and vh (2), for multiple bands in the NIZ only, with the strongest effect in the lower icEEG frequencies. Similarly, intra-modal h (2) and vh (2) were found to be differently modified as a function of different epileptic processes: compared to NIZ, [Formula: see text] was higher in IZ1, but lower in IZ2, while [Formula: see text] showed the inverse pattern. This corroborates previous observations of inter-modal connectivity discrepancies in pathological cortices, while providing the first direct invasive and simultaneous comparison in humans. We also studied time-resolved FC variability multimodally for the first time, finding that IZ1 shows both elevated internal [Formula: see text] and less rich dynamical variability, suggesting that its chronic role in epileptogenesis may be linked to greater homogeneity in self-sustaining pathological oscillatory states.

  13. In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods.

    PubMed

    Alvarado-Ramírez, Eidi; Torres-Rodríguez, Josep M

    2007-07-01

    The in vitro susceptibility of Sporothrix schenckii to antifungal drugs has been determined with three different methods. Nineteen Peruvian clinical isolates of S. schenckii were tested against amphotericin B (AB), flucytosine (FC), fluconazole (FZ), itraconazole (IZ), voriconazole (VZ), and ketoconazole (KZ). Modified NCCLS M38-A, Sensititre YeastOne (SYO), and ATB Fungus 2 (ATBF2) methods were used to determine the MICs. ATCC isolates of Candida parapsilosis, Candida krusei, and Aspergillus flavus were used for quality control. Sporothrix inocula were prepared with the mycelial form growing on potato dextrose agar at 28 +/- 2 degrees C. MICs of AB, FC, FZ, and IZ were determined with all three methods, VZ with M38-A and SYO, and KZ with only SYO. The three methods showed high MICs of FZ and FC (MIC(90) of 0.5 microg/ml), being homogeneously lower than those of IZ and KZ. The M38-A method showed a variable MIC range of VZ (4.0 to 16 microg/ml); the geometric mean (GM) was 9.3 mug/ml. The MIC range of AB was wide (0.06 to 16 microg/ml), but the GM was 1.2 microg/ml, suggesting that the MIC is strain dependent. Agreement (two log(2) dilutions) between commercial techniques and the modified M38-A method was very high with FZ, IZ, and FC. In AB and VZ, the agreement was lower, being related to the antifungal concentrations of each method. The highest activity against S. schenckii was found with IZ and KZ. Lack of activity was observed with FZ, VZ, and FC. When AB is indicated for sporotrichosis, the susceptibility of the strain must be analyzed. Commercial quantitative antifungal methods have a limited usefulness in S. schenckii.

  14. Surface Electrical Potentials of Root Cell Plasma Membranes: Implications for Ion Interactions, Rhizotoxicity, and Uptake

    PubMed Central

    Wang, Yi-Min; Kinraide, Thomas B.; Wang, Peng; Hao, Xiu-Zhen; Zhou, Dong-Mei

    2014-01-01

    Many crop plants are exposed to heavy metals and other metals that may intoxicate the crop plants themselves or consumers of the plants. The rhizotoxicity of heavy metals is influenced strongly by the root cell plasma membrane (PM) surface’s electrical potential (ψ0). The usually negative ψ0 is created by negatively charged constituents of the PM. Cations in the rooting medium are attracted to the PM surface and anions are repelled. Addition of ameliorating cations (e.g., Ca2+ and Mg2+) to the rooting medium reduces the effectiveness of cationic toxicants (e.g., Cu2+ and Pb2+) and increases the effectiveness of anionic toxicants (e.g., SeO42− and H2AsO4−). Root growth responses to ions are better correlated with ion activities at PM surfaces ({IZ}0) than with activities in the bulk-phase medium ({IZ}b) (IZ denotes an ion with charge Z). Therefore, electrostatic effects play a role in heavy metal toxicity that may exceed the role of site-specific competition between toxicants and ameliorants. Furthermore, ψ0 controls the transport of ions across the PM by influencing both {IZ}0 and the electrical potential difference across the PM from the outer surface to the inner surface (Em,surf). Em,surf is a component of the driving force for ion fluxes across the PM and controls ion-channel voltage gating. Incorporation of {IZ}0 and Em,surf into quantitative models for root metal toxicity and uptake improves risk assessments of toxic metals in the environment. These risk assessments will improve further with future research on the application of electrostatic theory to heavy metal phytotoxicity in natural soils and aquatic environments. PMID:25493475

  15. Novel products generated from 2'-deoxyguanosine by hypochlorous acid or a myeloperoxidase-H2O2-Cl- system: identification of diimino-imidazole and amino-imidazolone nucleosides.

    PubMed

    Suzuki, Toshinori; Masuda, Mitsuharu; Friesen, Marlin D; Fenet, Bernard; Ohshima, Hiroshi

    2002-06-01

    Hypochlorous acid (HOCl), generated by myeloperoxidase from H2O2 and Cl-, plays an important role in host defense and inflammatory tissue injury. We report here the identification of products generated from 2'-deoxyguanosine (dGuo) with HOCl. When 1 mM dGuo and 1 mM HOCl were reacted at pH 7.4 and 37 degrees C for 15 min and the reaction was terminated with N-acetylcysteine (N-AcCys), two products were generated in addition to 8-chloro-2'-deoxyguanosine (8-Cl-dGuo). One was identified as an amino-imidazolone nucleoside (dIz), a previously reported product of dGuo with other oxidation systems. The other was identified as a novel diimino-imidazole nucleoside, 2,5-diimino-4-[(2-deoxy-beta-D-erythro-pentofuranosyl)amino]-2H,5H-imidazole (dDiz) by spectrometric measurements. The yields were 1.4% dDiz, 0.6% dIz and 2.4% 8-Cl-dGuo, with 61.5% unreacted dGuo. Precursors of dDiz and dIz containing a chlorine atom were found in the reaction solution in the absence of termination by N-AcCys. dDiz, dIz and 8-Cl-dGuo were also formed from the reaction of dGuo with myeloperoxidase in the presence of H2O2 and Cl- under mildly acidic conditions. These results imply that dDiz and dIz are generated from dGuo via chlorination by electrophilic attack of HOCl and subsequent dechlorination by N-AcCys. These products may play a role in cytotoxic and/or genotoxic effects of HOCl.

  16. Internal morphology, habit and U-Th-Pb microanalysis of amphibolite-to-granulite facies zircons: geochronology of the Ivrea Zone (Southern Alps)

    NASA Astrophysics Data System (ADS)

    Vavra, Gerhard; Schmid, Rolf; Gebauer, Dieter

    Several types of growth morphologies and alteration mechanisms of zircon crystals in the high-grade metamorphic Ivrea Zone (IZ) are distinguished and attributed to magmatic, metamorphic and fluid-related events. Anatexis of pelitic metasediments in the IZ produced prograde zircon overgrowths on detrital cores in the restites and new crystallization of magmatic zircons in the associated leucosomes. The primary morphology and Th-U chemistry of the zircon overgrowth in the restites show a systematic variation apparently corresponding to the metamorphic grade: prismatic (prism-blocked) low-Th/U types in the upper amphibolite facies, stubby (fir-tree zoned) medium-Th/U types in the transitional facies and isometric (roundly zoned) high-Th/U types in the granulite facies. The primary crystallization ages of prograde zircons in the restites and magmatic zircons in the leucosomes cannot be resolved from each other, indicating that anatexis in large parts of the IZ was a single and short lived event at 299+/-5Ma (95% c. l.). Identical U/Pb ages of magmatic zircons from a metagabbro (293+/-6Ma) and a metaperidotite (300+/-6Ma) from the Mafic Formation confirm the genetic context of magmatic underplating and granulite facies anatexis in the IZ. The U-Pb age of 299+/-5Ma from prograde zircon overgrowths in the metasediments also shows that high-grade metamorphic (anatectic) conditions in the IZ did not start earlier than 20Ma after the Variscan amphibolite facies metamorphism in the adjacent Strona-Ceneri Zone (SCZ). This makes it clear that the SCZ cannot represent the middle to upper crustal continuation of the IZ. Most parts of zircon crystals that have grown during the granulite facies metamorphism became affected by alteration and Pb-loss. Two types of alteration and Pb-loss mechanisms can be distinguished by cathodoluminescence imaging: zoning-controlled alteration (ZCA) and surface-controlled alteration (SCA). The ZCA is attributed to thermal and/or decompression pulses

  17. Role of collateral blood flow in the apparent disparity between the extent of abnormal wall thickening and perfusion defect size during acute myocardial infarction and demand ischemia.

    PubMed

    Leong-Poi, Howard; Coggins, Matthew P; Sklenar, Jiri; Jayaweera, Ananda R; Wang, Xin-Qun; Kaul, Sanjiv

    2005-02-15

    The aim of this study was to test the hypothesis that the apparent disparity between the circumferential extent of abnormal wall thickening (WT) and that of infarct size (IS) at rest or size of ischemic zone (IZ) during demand ischemia (DI) is principally due to the effects of collateral blood flow (CollBF). A disparity has been reported between the circumferential extent of abnormal WT and that of IS at rest or IZ size during DI. Wall thickening and CollBF were measured in 18 dogs: at 6 h after coronary occlusion (Group 1, n = 6), and during 40 microg x kg x min(-1) of dobutamine in the presence of either one-vessel (Group 2, n = 6) or two-vessel stenosis (Group 3, n = 6). The apparent overestimation of the IS by the circumferential extent of abnormal WT was due to intermediate levels of CollBF in border zones within the risk area that had escaped necrosis. Although reduced, WT in these regions was commensurate with the level of flow. Similarly, during DI, regions within the IZ exhibiting the worst WT in Group 2 and 3 dogs were those not supplied by CollBF. The regions supplied by CollBF had intermediate WT, which was also commensurate with the level of flow. Only in two Group 3 dogs was tethering seen in small, normally perfused regions that were interspersed between two large IZ. Excluding these few tethered regions, data from different myocardial regions (infarcted, ischemic, CollBF dependent, and normal) were described by a single relation: y = 57(1 - e([-0.72(x - 0.06)])) (r = 0.80, p < 0.001). Myocardial regions at the margins of ischemic territories contribute to the apparent disparity between the circumferential extent of abnormal WT and IS or IZ during DI. In most circumstances, these regions are supplied by collaterals and their WT is commensurate with the degree of myocardial blood flow. The apparent disparity between the circumferential extent of WT and ischemia is rarely due to myocardial tethering, which is seen only in some instances of multi

  18. Spectroscopic and structural studies of quinoline derivatives—II. Forrier transform i.r. spectroscopy. 1. Rotational isomerism in 3-ethoxycarbonyl-4(1H)-quinolone and some of its substituted derivatives,

    NASA Astrophysics Data System (ADS)

    Mirek, Julian; Urbanek, Zbigniew H.

    Rotational isomerism associated with internal rotation about the ring carbon(3)-ester carbonyl carbon single bond in a series of 3-ethoxycarbonyl-4(1H)-quinolones have been investigated spectroscopically in the solid state using Fourier transform i.r. and laser Raman spectroscopy. Particular attention is given to the 1700, 1300 and 1100 cm -1 spectral regions related primarily to the vibrations of the CO 2C 2H 5 group. Within these regions rotational isomerism appeared in the compounds examined. The conformational changes are discussed and evidence is reported for occurrence of the unsubstituted compound 1 itself in the solid state at ambient temperature as an equilibrium mixture of both the s-trans ( 1a) and s-cis ( 1b) rotamers (this is in contrast to previous findings), and of its Bz-substituted derivatives.

  19. Bioinspired Asymmetric Synthesis of Hispidanin A.

    PubMed

    Li, Fuzhuo; Tu, Qian; Chen, Sijia; Zhu, Lei; Lan, Yu; Gong, Jianxian; Yang, Zhen

    2017-05-15

    The first enantiospecific synthesis of hispidanin A (4), a dimeric diterpenoid from the rhizomes of Isodon hispida, was achieved with a longest linear sequence of 12 steps in 6.5 % overall yield. A key component is the use of the abundant and naturally occurring diterpenoids (+)-sclareolide and (+)-sclareol as starting materials, which enables the gram-scale preparation of the key intermediates totarane (1) and s-trans-12E,14-labdadien-20,8β-olide (2). Subsequently a thermal or an erbium-catalyzed intermolecular Diels-Alder reaction of totarane (1) with labdadienolide (2) provide convergent and rapid access to the natural product hispidanin A (4). The synthetic studies have offered significant impetus for the efficient construction of these architecturally complex natural products. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Rapid quenching effects in glassy polymers

    NASA Technical Reports Server (NTRS)

    Mcgarry, F. J.

    1982-01-01

    Using a specially constructed microbalance for hydrostatic weighing, density changes in PVC thin film due to rapid quenching through the glass transition temperature were observed. The more severe the quench, the greater the free volume content. Isobaric volume recovery of PVC was also studied by volume dilatometry. Both show aging of relaxing molecular rearrangements taking place as a linear function of logarithmic aging time at room temperature. Distribution of retardation times and Primak's distributed activation energy spectra were applied to the volume recovery data. The concomitant changes in mechanical properties of PVC after quenching were monitored by tensile creep stress-stran to failure rates. All reflect the presence of excess free volume content due to rapid quenching.

  1. Ultraviolet Absorption Spectrum of Malonaldehyde in Water Is Dominated by Solvent-Stabilized Conformations.

    PubMed

    Xu, Xuefei; Zheng, Jingjing; Truhlar, Donald G

    2015-07-01

    Free energy calculations for eight enol isomers of malonaldehyde (MA) and simulation of the ultraviolet (UV) absorption spectrum in both the gas phase and water (pH = 3, where the molecule exists in neutral undeprotonated form) show that in water the two s-trans nonchelated enol conformers of MA become thermodynamically more stable than the internally hydrogen-bonded ("chelated enol") conformer (CE). The pure CE conformer in water has a slightly red-shifted UV spectrum with respect to that in the gas phase, but the blue-shifted spectrum observed in water at pH 3 is dominated by solvent-stabilized conformations that have negligible populations in the gas phase. Density functional calculations with the solvation model based on density (SMD) and an ensemble-averaged vertical excitation model explain the experimental observations in detail.

  2. Oriented Scintillation Spectrometer Experiment (OSSE). Volume 1. Revision A

    DTIC Science & Technology

    1988-05-19

    on SSUN$B off MDPOS $B on STRAN$B3 off FDET1$P 0080 Hex FDET2$P 0080 Hlex CAt’TH$P 138 CMREJ$P 0 FDET3$P 0080 Hex BAUTH$P 10 BCREJ$P 0 FDET4$P 0080...1-7A 43 2.3 46 Fig. 2-3 47 Fig. 2-4 50 3.1 74 3.4-1.1-1 77 Table 3-16 123 3.5.3-1-e 124 3.5.3-1-j & 3.5.3-5 134 3.5.5 143 4.1- 10 , 11 Acc?sion Fo...34 2-2-9 OSSE CONNECTOR PIN ASSIGNMENT .................. 35 2-2- 10 OSSE CONNECTOR PIN ASSIGNMENT .................. 36 2-2-11 OSSE

  3. A Pilot Plant Scale Reactor/Separator for Ethanol from Cellulosics. ERIP/DOE Quarterly Reports 7, 8 and Final report

    SciTech Connect

    Cale, M. Clark; Moelhman, Mark

    1999-09-30

    The objective of this project was to develop and demonstrate a continuous low energy process for the conversion of cellulosics to ethanol. BPI's process involves a proprietary low temperature pretreatment step which allows recycle of the pretreatment chemicals and recovery of a lignin stream. The pretreated biomass is then converted to glucans and xylans enzymatically and these sugars simultaneously fermented to ethanol (SSF) in BPI's Continuous Stirred Reactor Separator (CSRS). The CSRS is a multi stage bio-reactor where the glucans are first converted to ethanol using a high temperature tolerant yeast stran, followed by xylan SSF on the lower stages using a second xylose fermenting yeast strain. Ethanol is simultaneously removed from the bio-reactor stages, speeding the fermentation, and allowing the complete utilization of the biomass.

  4. QM/MM Study of Dehydro and Dihydro β-Ionone Retinal Analogues in Squid and Bovine Rhodopsins: Implications for Vision in Salamander Rhodopsin

    PubMed Central

    Sekharan, Sivakumar; Altun, Ahmet; Morokuma, Keiji

    2010-01-01

    Visual pigment rhodopsin provides a decisive crossing point for interaction between organisms and environment. Naturally occurring visual pigments contain only PSB11 and 3,4-dehydro-PSB11 as chromophores. Therefore, the ability of visual opsin to discriminate between the retinal geometries is investigated by means of QM/MM incorporation of PSB11, 6-s-cis and 6-s-trans forms of 3,4-dehydro-PSB11, 3,4-dehydro-5,6-dihydro-PSB11, 5,6-dihydro-PSB11 analogues into squid and bovine rhodopsin environments. The analogue-protein interaction reveals the binding site of squid rhodopsin to be malleable and ductile, while that of bovine rhodopsin to be rigid and stiff. On the basis of these studies, a tentative model of salamander rhodopsin binding site is also proposed. PMID:20964383

  5. Hydroxyapatite catalyzed aldol condensation: Synthesis, spectral linearity, antimicrobial and insect antifeedant activities of some 2,5-dimethyl-3-furyl chalcones

    NASA Astrophysics Data System (ADS)

    Subramanian, M.; Vanangamudi, G.; Thirunarayanan, G.

    2013-06-01

    A series of 2,5-dimethyl-3-furyl chalcones [2E-1-(2,5-dimethyl-3-furyl)-3-(substituted phenyl)-2-propen-1-ones] have been synthesized by Hydrotalcite catalyzed aldol condensation between 3-acetyl-2,5-dimethylfuron and substituted benzaldehydes. Yields of chalcones are more than 80%. These chalcones were characterized by their physical constants and spectral data. The group frequencies of infrared ν(cm-1) of CO s-cis and s-trans, CH in-plane and out of plane, CHdbnd CH out of plane, lbond2 Cdbnd Crbond2 out of plane modes, NMR chemical shifts δ(ppm) of Hα, Hβ, CO, Cα and Cβ of these chalcones were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analyses. From the results of statistical analyses, the effects of substituents on the group frequencies are explained. Antibacterial, antifungal and insect antifeedant activities of these chalcones have been studied.

  6. γ-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state (19)F-NMR peptide studies.

    PubMed

    Kubyshkin, Vladimir; Afonin, Sergii; Kara, Sezgin; Budisa, Nediljko; Mykhailiuk, Pavel K; Ulrich, Anne S

    2015-03-21

    γ-(4S)-Trifluoromethyl proline was synthesised according to a modified literature protocol with improved yield on a multigram scale. Conformational properties of the amide bond formed by the amino acid were characterised using N-acetyl methyl ester model. The amide populations (s-trans vs. s-cis) and thermodynamic parameters of the isomerization were found to be similar to the corresponding values for intact proline. Therefore, the γ-trifluoromethyl proline was suggested as a structurally low-disturbing proline substitution in peptides for their structural studies by (19)F-NMR. Indeed, the exchange of native proline for γ-trifluoromethyl proline in the peptide antibiotic gramicidin S was shown to preserve the overall amphipathic peptide structure. The utility of the amino acid as a selective (19)F-NMR label was demonstrated by observing the re-alignment of the labelled gramicidin S in oriented lipid bilayers.

  7. Ultraviolet Absorption Spectrum of Malonaldehyde in Water Is Dominated by Solvent-Stabilized Conformations

    SciTech Connect

    Xu, Xuefei; Zheng, Jingjing; Truhlar, Donald G.

    2015-07-01

    Free energy calculations for eight enol isomers of malonaldehyde (MA) and simulation of the ultraviolet (UV) absorption spectrum in both the gas phase and water (pH = 3, where the molecule exists in neutral undeprotonated form) show that in water the two s-trans nonchelated enol conformers of MA become thermodynamically more stable than the internally hydrogen-bonded (“chelated enol”) conformer (CE). The pure CE conformer in water has a slightly red-shifted UV spectrum with respect to that in the gas phase, but the blue-shifted spectrum observed in water at pH 3 is dominated by solvent-stabilized conformations that have negligible populations in the gas phase. Density functional calculations with the solvation model based on density (SMD) and an ensemble-averaged vertical excitation model explain the experimental observations in detail.

  8. Open-chain unsaturated selanyl sulfides: stereochemical structure and stereochemical behavior of their 77Se-1H spin-spin coupling constants.

    PubMed

    Rusakov, Yury Yu; Krivdin, Leonid B; Penzik, Maxim V; Potapov, Vladimir A; Amosova, Svetlana V

    2012-10-01

    Stereochemical structure of nine Z-2-(vinylsulfanyl)ethenylselanyl organyl sulfides has been investigated by means of experimental measurements and second-order polarization propagator approach calculations of their (1)H-(1)H, (13)C-(1)H, and (77)Se-(1)H spin-spin coupling constants together with a theoretical conformational analysis performed at the MP2/6-311G** level. All nine compounds were shown to adopt the preferable skewed s-cis conformation of their terminal vinylsulfanyl group, whereas the favorable rotational conformations with respect to the internal rotations around the C-S and C-Se bonds of the internal ethenyl group are both skewed s-trans. Stereochemical trends of (77)Se-(1)H spin-spin coupling constants originating in the geometry of their coupling pathways and the selenium lone pair effect were rationalized in terms of the natural J-coupling analysis within the framework of the natural bond orbital approach.

  9. Methyl (E)-3-(2-formyl-phen-oxy)acrylate.

    PubMed

    Karthikeyan, S; Sethusankar, K; Selvakumar, R; Bakthadoss, M

    2014-06-01

    In the title compound, C11H10O4, the methyl acrylate sub-stituent adopts an extended E conformation with all torsion angles close to 180°. The conformation of the keto group with respect to the olefinic double bond is typically S-trans. In the crystal, mol-ecules are linked via pairs of C-H⋯O hydrogen bonds, forming inversion dimers with an R 2 (2)(8) graph-set motif. The dimers are further linked via C-H⋯O hydrogen bonds, forming chains along [001], which enclose R 3 (2)(16) graph-set ring motifs. The keto group O atomaccepts two C-H⋯O interactions.

  10. Theoretical in-Solution Conformational/Tautomeric Analyses for Chain Systems with Conjugated Double Bonds Involving Nitrogen(s)

    PubMed Central

    Nagy, Peter I.

    2015-01-01

    Conformational/tautomeric transformations for X=CH–CH=Y structures (X = CH2, O, NH and Y = NH) have been studied in the gas phase, in dichloromethane and in aqueous solutions. The paper is a continuation of a former study where s-cis/s-trans conformational equilibria were predicted for analogues. The s-trans conformation is preferred for the present molecules in the gas phase on the basis of its lowest internal free energy as calculated at the B97D/aug-cc-pvqz and CCSD(T)CBS (coupled-cluster singles and doubles with non-iterative triples extrapolated to the complete basis set) levels. Transition state barriers are of 29–36 kJ/mol for rotations about the central C–C bonds. In solution, an s-trans form is still favored on the basis of its considerably lower internal free energy compared with the s-cis forms as calculated by IEF-PCM (integral-equation formalism of the polarizable continuum dielectric solvent model) at the theoretical levels indicated. A tetrahydrate model in the supermolecule/continuum approach helped explore the 2solute-solvent hydrogen bond pattern. The calculated transition state barrier for rotation about the C–C bond decreased to 27 kJ/mol for the tetrahydrate. Considering explicit solvent models, relative solvation free energies were calculated by means of the free energy perturbation method through Monte Carlo simulations. These calculated values differ remarkably from those by the PCM approach in aqueous solution, nonetheless the same prevalent conformation was predicted by the two methods. Aqueous solution structure-characteristics were determined by Monte Carlo. Equilibration of conformers/tautomers through water-assisted double proton-relay is discussed. This mechanism is not viable, however, in non-protic solvents where the calculated potential of mean force curve does not predict remarkable solute dimerization and subsequent favorable orientation. PMID:25984602

  11. Vibrational structure of n-π* transition of the UV absorption spectrum of acryloyl fluoride in the gas phase.

    PubMed

    Koroleva, Lidiya A; Tyulin, Vladimir I; Matveev, Vladimir K; Pentin, Yuriy A

    2014-03-25

    UV absorption spectrum of acryloyl fluoride molecule in the gas phase has been obtained in the region at 32600-35500 cm(-1) with the purpose of the investigation of the hindered internal rotation. The resolved vibrational structure of this spectrum consists of 92 absorption bands, each of which corresponds to a certain transition from the ground (S0) to excited (S1) electronic state. The assignment of all bands has been made. The values ν00trans=34831.8 cm(-1) and ν00cis=34679.2 cm(-1) have been determined. Several Deslandres Tables (DTs) have been constructed for torsional vibration of s-trans- and s-cis-isomers of investigated molecule. The origins in these DTs correspond to bands assigned to ν00 and to fundamental frequencies of each isomer in the S0 and S1 states. These DTs have been used to determine the harmonic frequencies ωe, anharmonicity coefficients x11, and frequencies of the torsional vibration transitions (0-υ) up to high values of the vibrational quantum number υ of s-trans- and s-cis-isomers in the both electronic states. The frequencies of torsional vibrations are ν1(″)=116.5cm(-1) for s-trans-isomer and ν1(″)=101.2 cm(-1) for s-cis-isomer in the S0 state. The frequencies of ones are ν1(')=170.4 cm(-1) for s-trans-isomer and ν1(')=139.7 cm(-1) for s-cis-isomer in the S1 state. The fundamental vibrational frequencies set has been found for isomers in the S0 and S1 states.

  12. Syntactic and morphosyntactic processing in stroke-induced and primary progressive aphasia.

    PubMed

    Thompson, Cynthia K; Meltzer-Asscher, Aya; Cho, Soojin; Lee, Jiyeon; Wieneke, Christina; Weintraub, Sandra; Mesulam, M-Marsel

    2013-01-01

    The paper reports findings derived from three experiments examining syntactic and morphosyntactic processing in individuals with agrammatic and logopenic variants of primary progressive aphasia (PPA-G and PPA-L, respectively) and stroke-induced agrammatic and anomic aphasia (StrAg and StrAn, respectively). We examined comprehension and production of canonical and noncanonical sentence structures and production of tensed and nontensed verb forms using constrained tasks in experiments 1 and 2, using the Northwestern Assessment of Verbs and Sentences (NAVS [57]) and the Northwestern Assessment of Verb Inflection (NAVI, Thompson and Lee, experimental version) test batteries, respectively. Experiment 3 examined free narrative samples, focusing on syntactic and morphosyntactic measures, i.e. production of grammatical sentences, noun to verb ratio, open-class to closed-class word production ratio, and the production of correctly inflected verbs. Results indicate that the two agrammatic groups (i.e., PPA-G and StrAg) pattern alike on syntactic and morphosyntactic measures, showing more impaired noncanonical compared to canonical sentence comprehension and production and greater difficulties producing tensed compared to nontensed verb forms. Their spontaneous speech also contained significantly fewer grammatical sentences and correctly inflected verbs, and they produced a greater proportion of nouns compared to verbs, than healthy speakers. In contrast, PPA-L and StrAn individuals did not display these deficits, and performed significantly better than the agrammatic groups on these measures. The findings suggest that agrammatism, whether induced by degenerative disease or stroke, is associated with characteristic deficits in syntactic and morphosyntactic processing. We therefore recommend that linguistically sophisticated tests and narrative analysis procedures be used to systematically evaluate the linguistic ability of individuals with PPA, contributing to our

  13. Syntactic and Morphosyntactic Processing in Stroke-Induced and Primary Progressive Aphasia

    PubMed Central

    Thompson, Cynthia K.; Meltzer-Asscher, Aya; Cho, Soojin; Lee, Jiyeon; Wieneke, Christina; Weintraub, Sandra; Mesulam, M.-Marsel

    2013-01-01

    The paper reports findings derived from three experiments examining syntactic and morphosyntactic processing in individuals with agrammatic and logopenic variants of primary progressive aphasia (PPA-G and PPA-L, respectively) and stroke-induced agrammatic and anomic aphasia (StrAg and StrAn, respectively). We examined comprehension and production of canonical and noncanonical sentence structures and production of tensed and nontensed verb forms using constrained tasks in experiments 1 and 2, using the Northwestern Assessment of Verbs and Sentences (NAVS [57]) and the Northwestern Assessment of Verb Inflection (NAVI, Thompson and Lee, experimental version) test batteries, respectively. Experiment 3 examined free narrative samples, focusing on syntactic and morphosyntactic measures, i.e. production of grammatical sentences, noun to verb ratio, open-class to closed-class word production ratio, and the production of correctly inflected verbs. Results indicate that the two agrammatic groups (i.e., PPA-G and StrAg) pattern alike on syntactic and morphosyntactic measures, showing more impaired noncanonical compared to canonical sentence comprehension and production and greater difficulties producing tensed compared to nontensed verb forms. Their spontaneous speech also contained significantly fewer grammatical sentences and correctly inflected verbs, and they produced a greater proportion of nouns compared to verbs, than healthy speakers. In contrast, PPA-L and StrAn individuals did not display these deficits, and performed significantly better than the agrammatic groups on these measures. The findings suggest that agrammatism, whether induced by degenerative disease or stroke, is associated with characteristic deficits in syntactic and morphosyntactic processing. We therefore recommend that linguistically sophisticated tests and narrative analysis procedures be used to systematically evaluate the linguistic ability of individuals with PPA, contributing to our

  14. Singular Instantons and Painlevé VI

    NASA Astrophysics Data System (ADS)

    Muñiz Manasliski, Richard

    2016-06-01

    We consider a two parameter family of instantons, which is studied in [Sadun L., Comm. Math. Phys. 163 (1994), 257-291], invariant under the irreducible action of SU_2 on S^4, but which are not globally defined. We will see that these instantons produce solutions to a one parameter family of Painlevé VI equations (P_VI}) and we will give an explicit expression of the map between instantons and solutions to P_{VI}. The solutions are algebraic only for that values of the parameters which correspond to the instantons that can be extended to all of S^4. This work is a generalization of [Muñiz Manasliski R., Contemp. Math., Vol. 434, Amer. Math. Soc., Providence, RI, 2007, 215-222] and [Muñiz Manasliski R., J. Geom. Phys. 59 (2009), 1036-1047, arXiv:1602.07221], where instantons without singularities are studied.

  15. The effect of different fabrication steps on the marginal adaptation of two types of glass-infiltrated ceramic crown copings fabricated by CAD/CAM technology.

    PubMed

    Alghazzawi, Tariq F; Liu, Perng-Ru; Essig, Milton E

    2012-04-01

    Marginal adaptation is an important factor affecting the longevity of all-ceramic restorations, although the effects of different fabrication steps on marginal adaptation at various stages of fabrication are not fully understood. The purpose of this study was to assess with an in vitro model whether In-Ceram alumina (IA) or In-Ceram zirconia (IZ) copings produced by the CAD/CAM method would be clinically acceptable, and to evaluate the effect of each fabrication step (post-milling, post-trimming, and post-glass infiltration) on the marginal discrepancy of the coping. A melamine tooth was prepared, duplicated, poured with inlay wax, and then cast with metal to fabricate a master die. An InLab 3D system was used to scan the master die and to design and mill the copings. Thirty IA and IZ copings each were developed with thicknesses of 0.6 mm and a 30-μm thick computer luting space. Epoxy resin replicas of the master die were fabricated, and the vertical and horizontal marginal discrepancies were measured using a Micro-Vu optical microscope at three stages of the fabrication (post-milling, post-trimming, post-infiltration). One-way ANOVA was used to analyze the data between the three stages of fabrication for each marginal discrepancy, and a t-test was used to compare vertical and horizontal marginal discrepancies (after glass infiltration) between IZ and IA copings There were no significant differences (p > 0.05) in the vertical marginal discrepancies (μm) between IA (36 ± 14) and IZ (40 ± 14) copings after glass infiltration. ANOVA (comparing three stages within horizontal marginal discrepancy for IZ copings) showed that post-milling (40 ± 26) > post-trimming (23 ± 11) = post-infiltration (19 ± 13). ANOVA (comparing three stages within vertical marginal discrepancy for IZ copings) showed that post-milling (53 ± 12) = post-trimming (47 ± 13) > post-infiltration (36 ± 14). ANOVA (comparing three stages within horizontal marginal discrepancy for IA copings

  16. Comparison of the Centers for Disease Control and Prevention-backpack and insectazooka aspirators for sampling Aedes polynesiensis in French Polynesia.

    PubMed

    Hapairai, Limb K; Sang, Michel A Cheong; Bossin, Hervé C

    2014-06-01

    The efficiency of the recently developed handheld InsectaZooka (IZ) aspirator was compared to that of the Centers for Disease Control and Prevention-Backpack (CDC-BP) aspirator by conducting human bait collections on 2 islets (locally called motus) of the atoll of Tetiaroa, French Polynesia. Abundance of mosquitoes was compared between the wind-exposed and wind-protected sides of each motu to measure the effect of wind on mosquito distribution. The number of host-seeking Aedes polynesiensis mosquitoes collected on the 2 motus with either sampling device was not significantly different. Collection of male mosquitoes was low irrespective of the type of aspirator used. Wind had an effect on mosquito distribution, as females were more abundant on the protected sides of both motus. The IZ aspirator is a lighter and equally efficient alternative to the CDC-BP aspirator for collecting Ae. polynesiensis.

  17. Reducing the duration of broadband excitation pulses using optimal control with limited RF amplitude.

    PubMed

    Skinner, Thomas E; Reiss, Timo O; Luy, Burkhard; Khaneja, Navin; Glaser, Steffen J

    2004-03-01

    Combining optimal control theory with a new RF limiting step produces pulses with significantly reduced duration and improved performance for a given maximum RF amplitude compared to previous broadband excitation by optimized pulses (BEBOP). The resulting pulses tolerate variations in RF homogeneity relevant for standard high-resolution NMR probes. Design criteria were transformation of Iz-->Ix over resonance offsets of +/-20kHz and RF variability of +/-5%, with a pulse length of 500 micros and peak RF amplitude equal to 17.5 kHz. Simulations transform Iz to greater than 0.995 Ix, with phase deviations of the final magnetization less than 2 degrees, over ranges of resonance offset and RF variability that exceed the design targets. Experimental performance of the pulse is in excellent agreement with the simulations. Performance tradeoffs for yet shorter pulses or pulses with decreased digitization are also investigated.

  18. Sampling and composition of airborne particulate matter (PM10) from two locations of Mexico City.

    PubMed

    Chirino, Yolanda I; Sánchez-Pérez, Yesennia; Osornio-Vargas, Álvaro Román; Rosas, Irma; García-Cuellar, Claudia María

    2015-09-01

    The PM10 airborne particulate matter with an aerodynamic diameter ≤10 µm is considered as a risk factor of various adverse health outcomes, including lung cancer. Here we described the sampling and composition of PM10 collected from an industrial zone (IZ), and a commercial zone (CZ) of Mexico City. The PM10 was collected with a high-volume sampler in the above mentioned locations and both types of PM10 sampled were characterized by the content of polycyclic aromatic hydrocarbons (PAHs), metals, and endotoxin. The endotoxin PM10 content from IZ and CZ displayed 138.4 UE/mg and 170.4 UE/mg of PM10, respectively.

  19. Reducing the duality gap in partially convex programming

    SciTech Connect

    Correa, R.

    1994-12-31

    We consider the non-linear minimization program {alpha} = min{sub z{element_of}D, x{element_of}C}{l_brace}f{sub 0}(z, x) : f{sub i}(z, x) {<=} 0, i {element_of} {l_brace}1, ..., m{r_brace}{r_brace} where f{sub i}(z, {center_dot}) are convex functions, C is convex and D is compact. Following Ben-Tal, Eiger and Gershowitz we prove the existence of a partial dual program whose optimum is arbitrarily close to {alpha}. The idea, corresponds to the branching principle in Branch and Bound methods. We describe such a kind of algorithm for obtaining the desired partial dual.

  20. VizieR Online Data Catalog: Stellar population in Chamaeleon I (Luhman, 2007)

    NASA Astrophysics Data System (ADS)

    Luhman, K. L.

    2009-05-01

    Optical and near-IR broadband photometry from several sources (2MASS and DENIS for IK1 & IK2) were used to perform four surveys (IK1, RI, IK2, IZ). For RI, on the night of 2004 January 11, R- and I-band images obtained with the Inamori Magellan Areal Camera and Spectrograph (IMACS) on the Magellan I telescope at Las Campanas Observatory were used. Deep optical and near-IR images of the densest portion of the southern subcluster that were obtained by Luhman et al. (2005ApJ...635L..93L,) collected with the Advanced Camera for Surveys (ACS) aboard HST through the F775W and F850LP filters were used for IZ. (6 data files).

  1. Hyperfine structure and nuclear hyperpolarization observed in the bound exciton luminescence of Bi donors in natural Si.

    PubMed

    Sekiguchi, T; Steger, M; Saeedi, K; Thewalt, M L W; Riemann, H; Abrosimov, N V; Nötzel, N

    2010-04-02

    As the deepest group-V donor in Si, Bi has by far the largest hyperfine interaction and also a large I = 9/2 nuclear spin. At zero field this splits the donor ground state into states having total spin 5 and 4, which are fully resolved in the photoluminescence spectrum of Bi donor bound excitons. Under a magnetic field, the 60 expected allowed transitions cannot be individually resolved, but the effects of the nuclear spin distribution, -9/2 < or = I(z) < or = 9/2, are clearly observed. A strong hyperpolarization of the nuclear spin towards I(z) = -9/2 is observed to result from the nonresonant optical excitation. This is very similar to the recently reported optical hyperpolarization of P donors observed by EPR at higher magnetic fields. We introduce a new model to explain this effect, and predict that it may be very fast.

  2. Gordon Research Conference on Dynamics of Macromolecular and Polyelectrolyte Solutions Held in Oxnard, California on 12-16 February 1990

    DTIC Science & Technology

    1990-04-01

    Polyelectrolyte Solutions* was held IZ-16 February, 1990, at Casa Sirena Hotel, Oxnard, CA There were ninety-one scientists iarticipatIng. ’cludiq thirty-four...MACROMOLECULAR AND POLYELECT’ROLYTE 5’LUToNS Casa Sirena . Oxnard. CA Lee Magid - Chairman Peter Pusey - VIce-Chairman Monday. February 12 S.J. Candau...12-16, 1990 Casa Sirena Marina Hotel Oxnard, California REGISTRATION LIST Bruce J. Ackerson 149 Sauver Candau 136 Oklahoma State University Universit4

  3. Flame Stabilization and Structure of Reaction Zones

    DTIC Science & Technology

    2009-03-31

    observed in many experiments (Muñiz and Mungal, 1997, Brown et al., 1999, Lee et al., 1997, Kalghatgi, 1984). Results of cinema -PIV (particle image...data. Upatnieks et al. (2004) used cinema -PIV to study turbulent flames and found that the propagation of the flame base was close to the laminar... Philosophy . California Institute of Technology, Pasadena, CA., 1-140. Hammer, J.A. and Roshko, A. (2000) Temporal behavior of lifted turbulent jet flames

  4. Project Information Management System (PIMS) for Military Construction: Functional Description.

    DTIC Science & Technology

    1980-10-01

    Each year, approximately 800 new construction projects costing over $2 billion are proposed by the Military Departments and Defense Agencies as...Congressional requirement 2-4 00-I IZ Q I.-t ~ zI ~us wi cm z CZ = = uI 4c m 4iCca -. 4 LldJ t0 ww caa o cr z 2-5 for new construction projects and updates to

  5. Supplemental Conceptual Design Study of an Integrated Voice/Data Switching and Multiplexing Technique for an Access Area Exchange

    DTIC Science & Technology

    1976-11-11

    Cabinet Rack* 550 - - 0 550 Uode Power Strely Cabinet Total Cost $750. * Item cost and systen usage iz based on ouantities needed for a 2-noee network...organization for system test and evaluation. In the system 1; 7- 1’---- organization, only the processing power , memoty capacity and terminal service...a formidable amount of raw processing power appears to have been provided in a modular structure, inter-processor communication/handshaking appears to

  6. Earth Resources. A Continuing Bibliography with Indexes

    DTIC Science & Technology

    1987-11-01

    CHARACTERISTICS OF THE RIFT PREDICTING THE LOCATION OF KIMBERLITE FROM A ZONE ON THE LAMBERT GLACIER (ANTARCTICA) PROBABILITY ANALYSIS OF LINEAR STRUCTURE ON...Issledovanie Zemli iz Kosmosa (ISSN 0205-9614), Nov.-Dec. 1986, to predict the location of kimberlite is described. Statistical analysis p. 38-47. In Russian...in northeastern China. A probability contour map of interpreted to reveal the zone’s geological features. A schematic kimberlite in th3 area is derived

  7. Feasibility of Standardized Rain Testing for Fuzes. Serial Number 1.0

    DTIC Science & Technology

    1981-06-01

    experiments with piezoelectric transducers for determining force-time from supersonic impacts in heavy rainfall are continuing.(1 6 ) Several...0 System Concept 73 Experiment and Tabulation of Results 75 References 79 Appendix A Photos from Study of 0-C-0 System Appendix B Rain Impact on PD...Tropical rain 51 12 Drop sizes and number in orifice flow experiment 76 IZ4 CONCLUSIONS 1. The nature of natural and spray rainfields is such that only a

  8. Understanding the Physics Behind Ionospheric and Plasmaspheric Density Irregularities by Utilizing Multi-Instrument Observations Data

    DTIC Science & Technology

    2013-04-01

    patterns occurred in all local time sectors. Our more than two years’ worth of data analysis showed that more significant occurrence of wave number four...hour per response, Including the time for reviewing instructions, searching existing data sources gathering and maintaining the data needed, and...Behind Ionospheric And Plasmpheric Density Irregularities by Uti l iz ing Multi-Instrument Observations Data 5a. COh TRACT NUMBER 5b. GRANT NUMBER

  9. Towards an informative mutant phenotype for every bacterial gene

    SciTech Connect

    Deutschbauer, Adam; Price, Morgan N.; Wetmore, Kelly M.; Tarjan, Daniel R.; Xu, Zhuchen; Shao, Wenjen; Leon, Dacia; Arkin, Adam P.; Skerker, Jeffrey M.

    2014-08-11

    Mutant phenotypes provide strong clues to the functions of the underlying genes and could allow annotation of the millions of sequenced yet uncharacterized bacterial genes. However, it is not known how many genes have a phenotype under laboratory conditions, how many phenotypes are biologically interpretable for predicting gene function, and what experimental conditions are optimal to maximize the number of genes with a phenotype. To address these issues, we measured the mutant fitness of 1,586 genes of the ethanol-producing bacterium Zymomonas mobilis ZM4 across 492 diverse experiments and found statistically significant phenotypes for 89% of all assayed genes. Thus, in <i>Z. mobilis, most genes have a functional consequence under laboratory conditions. We demonstrate that 41% of <i>Z. mobilis genes have both a strong phenotype and a similar fitness pattern (cofitness) to another gene, and are therefore good candidates for functional annotation using mutant fitness. Among 502 poorly characterized <i>Z. mobilis genes, we identified a significant cofitness relationship for 174. For 57 of these genes without a specific functional annotation, we found additional evidence to support the biological significance of these gene-gene associations, and in 33 instances, we were able to predict specific physiological or biochemical roles for the poorly characterized genes. Last, we identified a set of 79 diverse mutant fitness experiments in <i>Z. mobilis that are nearly as biologically informative as the entire set of 492 experiments. Therefore, our work provides a blueprint for the functional annotation of diverse bacteria using mutant fitness.

  10. National Program for Inspection of Non-Federal Dams. Lake Madeleine (VT 00007) Hudson River Basin, Sandgate. Phase I Inspection Report.

    DTIC Science & Technology

    1978-09-01

    PROJECT FEATURE NAME M. R. Peloso DISCIPLINE NAME AREA EVALUATED CONDITION OUTLET WORKS - CONTROL TOWER a. Concrete and Structural General Condition...ELEMENT PROJECT, TASK AREA 4 WORK UNIT NUMBERS 11. CONTROLLING OFFICE NAME AND ADDRELSS IZ. RSPORT DATE DEPT. OF THE ARMY: CORPS OF ENGINEERS September... Works There are three outlets from Lake Madeleine. They are: the penst ock, the overflow pipe and the emergency spill- way. The primary outlet used for

  11. Design of an Instructional Strategy to Teach Visualization in an Advection Context in Intelligent Computer-Assisted Instruction.

    DTIC Science & Technology

    1991-05-01

    of the domain of advection. Advection is the process that transports atmospheric properties (e.g., temperature) by the wind. Advection is usually...program to teach approximately an hour of the domain of advection. Advection iz the process that transports atmospheric properties (e.g...advection. Advection is the process that transports atmospheric properties (e.g., temperature) by the wind. Advection is usually used to describe

  12. A Prospective Study of Factors Affecting Recovery from Musculoskeletal Injuries

    DTIC Science & Technology

    2014-01-01

    for musculoskeletal disorders . J Occup Rehabil. 2005;15:377–92. 18. Crook J, Milner R, Schultz IZ, Stringer B. Determinants of occupational disability...Spine. 1996;21:2900–7. 61. Hansson T, Jensen I. Sickness absence due to back and neck disorders . Scan J Public Health. 2004;32:109–51. 62. Lincoln AE...Naval Health Research Center A Prospective Study of Factors Affecting Recovery from Musculoskeletal Injuries Stephanie Booth-Kewley Emily

  13. Myungshin Im, Won-Kee Park, Changsu Choi, Yiseul Jeon, Ji-Hoon Kim (CEOU/SNU), Giseon Baek, Young-Seok Oh, Soojong Pak (Kyunghee Univ.)

    NASA Astrophysics Data System (ADS)

    Im, Myungshin; Park, Won-Kee; Choi, Changsu; Jeon, Yiseul; Kim, Ji-Hoon; Baek, Giseon; Oh, Young-Seok; Pak, Soojong

    2011-08-01

    On August 30 02:05 UT, we started observations of SN2011fe=PTF11kly (ATel#3581) in grizY and is/iz-bands using CQUEAN on the 2.1m telescope at McDonald observatory, and in zYJHK-bands using UKIRT. SN2011fe is found to have J~11.58 and K~11.55 mag (error~0.05 mag), still brightening in NIR with respect to ATel#3605.

  14. Chatanika Radar Measurements during the Auroral E Program

    DTIC Science & Technology

    1981-06-01

    region neutral winds have biased the elevation scan measurements. 16 0 WIAW -- 3 * I I I 0 -r I co I Iz aa ’I 0 Ii z J-4 * I i I0 0 w -J w4j w Cc 0 ~I U...V. Starkov , "Dynamics of Auroral Belt and Polar Geomagnetic Disturbances," Planet. Sp. Sci., 15, 209-229 (1967). Gussenhoven, M. S., D. A. Hardy

  15. Archaeological Investigations in the Gainesville Lake Area of the Tennessee-Tombigbee Waterway. Volume V. Archaeology of the Gainesville Lake Area: Synthesis.

    DTIC Science & Technology

    1982-09-01

    237 15. Sumary of Plant Food Remains from Miller III and Summerville I Features .. ......... . ........... 248 Iz zi j...Director of The University of Alabama, Office of Archaeological Research (OAR), believed that this project could be finish- ed and he perservered to see...economies based upon a few high-yield natural foods , and the earliest cultivation of native annuals. This final period in the Archaic sequence dates

  16. The Climate in the Region of Djerdap (The Iron Gate),

    DTIC Science & Technology

    1982-01-21

    this report. LITERATURE (1) Milosavljevi, K. und M.: Uticaj orografije na raspodeu pad ina u ZuWto- noj Srbij. Zbornzk radova Poljoprivrednog fakuiteta...i-i, (ion). (2) MilosavleviO K. und M.: Raspodela padavina u Isto~noj Srbiji pri vero- vima iz severozapadnog kvadranta. Zbornik meteoroakTh i...hidro1ikIh radova br. 1. Savezm hidrometeorolo~ki zavod, Bpograd, 1-9, (1963). 3. K. Milosavljevic, M. Milosavljevic. Effect of the Transylvanian Alps on

  17. VizieR Online Data Catalog: Photometric brown-dwarf classification (Skrzypek+, 2016)

    NASA Astrophysics Data System (ADS)

    Skrzypek, N.; Warren, S. J.; Faherty, J. K.

    2016-02-01

    Table 3 (L dwarfs) and Table 4 (T dwarfs) provide coordinates and photometry of the 1281 L dwarfs and 80 T dwarfs, J<17.5, found by Skrzypek et al. 2016 using the photo-type classification method. Coordinates and photometry in izYJHKW1W2 (on the Vega system) is provided, as well as the photo-type classification, and any existing spectroscopic classification in the literature. (3 data files).

  18. By Too Many Names - Operational Momentum.

    DTIC Science & Technology

    1994-06-17

    AD-A283 467 7, TC O ""SITcurity CSaTEN A: AROEFRTUL i t t oRva a i t o p o rMEL E AS TE ; O N pD IST R B U II ISC U N IM I R. aport Security... Watson , USN Chairman, Department of Military Operations ,2 94-25972 el David P. Ober aler, USA Date Faculty Research Advisor 948 16 123 DT]C ,IL±iz

  19. Election Verifiability: Cryptographic Definitions and an Analysis of Helios and JCJ

    DTIC Science & Technology

    2015-04-01

    Cortier, David Galindo , Markus Jakobsson, Steve Kremer, Ralf Küsters, Elizabeth Quaglia, Mark Ryan, Susan Thomson, and Poorvi Vora for insightful...IEEE Computer Society, 1985. [31] Véronique Cortier and David Galindo . Private communication, Nancy, France, 13th June 2013. [32] Véronique...Cortier, David Galindo , Stephane Glondu, and Malika Iz- abachène. Election Verifiability for Helios under Weaker Trust As- sumptions. In ESORICS’14: 19th

  20. Navy Recruitment Potential in Junior Colleges

    DTIC Science & Technology

    1975-07-01

    could be employed in recruitment advertising directed to this target market segment. ~~iZ Uncla ssifie d SECURITY CLAUIPIC~f(ATION OFf THIS PA09(Wh•l...Alexandria, Virginia, CR-ED-74-1, July 1974. Grey Advertising . Market Target Recruitmen~t Incentive Study for Enlisted Personnel (draft report, internal NRC...the recruiter or the various advertising media. Survey findings document the importance of the recruiter, and suggestpromising media and appeals which

  1. Cadmium (Tank) Electroplating Alternative

    DTIC Science & Technology

    2011-08-01

    Packages • Manuals • Specifications • Eng. Circular Technical Objectives Demo Site: FRC JAX FRCSE Toxic Metal Control Program (FRCSEINST 5103.15... chrome conversion coating for DIPSOL IZ-C17. ■ Blue bright coating/ excellent corrosion resistance. ■ Chromate film thickness is under 100nm...SEM Method Composition: 12 – 18% nickel Consistent Alloy Composition Thickness Microscopic ASTM B487 Thickness measurement (mils). Compare w/ LHE

  2. Air Force Successes and Challenges in Cr(VI) Elimination

    DTIC Science & Technology

    2011-05-10

    Cr(VI) has been used for 40+ years and is an excellent corrosion inhibitor • Cr(VI) compounds are highly toxic • National & International...use of Cr(VI) • Suitable Substitutes for Specific Applications are being Actively Sought 3 Chrome Reduction Plan Description: • Reduce Cr(VI) and...ion vapor deposited Al, and Cd coatings 2. Use trivalent chromium [Cr(III)] conversion coating (CC) on Dipsol IZ- C17+ zinc- nickel (Zn-Ni) coating

  3. Media/Device Configurations for Platoon Leader Tactical Training

    DTIC Science & Technology

    1985-02-01

    Liquid Crystal Flatbed Plotter Sonic D iz Display Drum Plotter S"Light Detector Multiple Digitizer Microprocessors "", P1 otter 4_j Graphic Film...resolution Printer pixel graphics 64K RAM monitor Some expansion Intercept-Beam 5 inch 8-bit 12 inch. low Voice Dot-Matrix or Touch- Floppy DIsk 6502A...chip resolution Synthesizer Printer Sensitive pixel graphics Screen or 64K RAM monitor plus Light Pen expandable Instructor’s monitor Keyboard and

  4. Meeting the Combat Stress Challenge: Special Psychological Intervention and Reintegration Teams (SPIRITs)

    DTIC Science & Technology

    1988-04-01

    S~AIR COMMAND AND STAFF COLLEGE STUDENT REPORT MEETING THE COMBAT STRESS CHALLENGE: SPECIAL PSYCHOLOGICAL INTERVENTION AND REINTEGRATION TEAMS...INTERVENTION AND REINTEGRATION TEAMS (SPIRITs) AUTHOR(S) MAJOR DAVID L. HERRES, USAF, BSC FACULTY ADVISOR CHAPLAIN, LT COL, DAVID W. FAHNER, USAF, ACSC/IHC...AND REINTEGRATION TEAMS (SPIRITs) IZ. PERSONAL AUTHOR(S) HERRES, DAVID L., MAJOR, USAF, BSC 13a. TYPE OF REPORT 13b.’TIME COVERED 14. DATE OF REPORT

  5. A Nomogram for Calculation of Oxygen Consumption from Minute Ventilation at Varying Workloads

    DTIC Science & Technology

    1979-07-01

    981~ IZ:;: I~ ~ TATL’MLNrh j.V Approved for public releasel ’ý [ I .Ad& - ABSTRACT .L Oxygen consumption can be difficult and time consuming to measure ...employed to evaluate diff-erent aspects of cardiopulmonary function (1). One of the principal measurements used to quantify response to exercise is...the oxygen consumption. The direct measurement of oxygen consumption is time consuming and cumbersome. Unfortunately, no reliable indirect method for

  6. Operational Principles. The Operational Art of Erwin Rommel and Bernard Montgomery

    DTIC Science & Technology

    1985-01-01

    7 OPERATIONAL PRINCIPLES: THE OPERATIONAL ART OF ERWIN ROMMEL AND BERNARD MONTGOMERY A thesis presented to the Faculty of the US Army Command and...h- rfrC -= S Leaven,pwnrth. iz0 27. - 85-3214 141 OPERATIONAL PRINCIPLES: THE OPERATIONAL ART OF ERWIN ROMMEL AND BERNARD MONTGOMERY A thesis...Principles: The Operational Art of Erwin Rommel and Bernard Montgomery. Approved by: esis Committee ChairmanTCD lsV2onson, MA) , _ __, Member, Graduate Faculty

  7. A new species of Tychobythinus Ganglbauer, 1896 (Coleoptera: Staphylinidae: Pselaphinae) from Turkey.

    PubMed

    Bekchiev, Rostislav

    2013-01-01

    A new species of the genus Tychobythinus Ganglbauer, 1896, Tychobythinusoculatus sp. n., is described from near Köyceğiz, Muğla Province, in southwestern Turkey. The new species is morphologically closely related to Tychobythinusabnormipes Reitter, 1910, and Tychobythinuspauper Kiesenwetter, 1858, but can be readily distinguished from both by having very simplified internal armature of the aedeagus, and by the specific shape of the gular depression.

  8. Letters

    NASA Astrophysics Data System (ADS)

    1999-01-01

    A Coordination Geometry Table by Francisco J. Arnáiz Re: article by D. Venkataraman, Y. Du, S. R. Wilson, K. A. Hirsch, P. Zhang, and J. S. Moore The authors reply Cut-Out Molecular Models by A. L. Silva, C. Fernandes, O. Wasterlain, S. Costa, and A. M. Mendes Re: article by R. J. Kashmar Kinetics Lesson for College Deans by Fred Hadley

  9. Tracking in Uncertain Environments

    DTIC Science & Technology

    1989-09-01

    information should be used for trajectory estimation. A filter which refines past estimates in the light of subsequent measurements is called a smoothing ...filter. In terms of the pdf of target state, for a smoothing filter we require: P(x-IZ1, *. Zn) where k < n . For standard filtering problems without...measurement uncertainty, efficient optimal smoothing algorithms have been derived (see Jazwinski 27). For trajectory estimation, it has been shown that

  10. Some Topics in Linear Estimation,

    DTIC Science & Technology

    1981-01-01

    outstanding symposium. Iz SOME TOPICS IN LINEAR ESTIMATION 309 TABILE OF CONTENTS 1. The Integral Equations of Smoothing and Filtering la. The Smoothing ... Smoothing and Filtering 2. Some Examples - Stationary Processes 2a. Scalar Stationary Processes over Infinite Intervals 2b. Finite Intervals - The...Stationary 4. A Concluding Remark 310 T. KAILATH 1. The Integral Equations of Smoothing and Filtering Our estimation problems will be discussed in the context

  11. Water Vapor as a Tracer in Remote Wind Sensing: A Feasibility Study.

    DTIC Science & Technology

    1982-08-01

    BY 04 1. L. Barber DTIC K ELECT E Approved for public release; distribution unlimited. C" D US Army Electronics Research and Development Command...14 D ATA ANALYSIS ........................................... . .......... 18 ""CONCL USI ONS...1T’TS GRA&I ,xc TAB U 13- :,-iounce d lii .j.-t, ifiat io -:.i 𔃼bility Codes Avnii and/or r~ir t pecialK IZ Le p.3 INTRODUCTION The military is becoming

  12. Programmable Cockpit - Flight Dynamic Model

    DTIC Science & Technology

    1990-07-01

    Airlines of Australia, Library Australian Airlines, Library Qantas Airways Limited Civil Aviation Authority Hawker de Havilland Aust Pty Ltd...detai as well as its limitations . A brief overview of the Programmable Cockpit is also given. -i*Q j, DSTO4 MELBOURNE (C) COMMONWEALTH OF AUSTRALIA...components Vt Aircraft true velocity Vil,. Limited aircraft true velocity X., Ya IZ. Aerodynamic forces in stability axes X,, Y, ZP Propulsive forces

  13. Set-Membership Identification for Robust Control Design

    DTIC Science & Technology

    1993-04-28

    Yb relates to gear tecth spacing for all t =1,...,N. and the slopes in the two regions relate to gear teeth shapes. Typically for IzI > Yb the slope is...function of the prediction error at the first time shift. Therefore, minimizing V2 will force jail to small values. This is a first attempt to whitening ...norm minimization. Note that the new norm forces the autocorrelation of the prediction error for nonzero shifts to small values ( whitens the prediction

  14. Technical and Operational Evaluation of USCGC DORADO (WSES-1).

    DTIC Science & Technology

    1982-08-01

    safely? Not observed Yes No 15. If no, what are the main prcblem areas? 116. co you thirk it is safe to put a swimmer in the water from this vessel...ize 1270 Toob i: I=1I* 10 1280 LimnLim/10 1i290 G* OT0 C hecr.k iz=e 1300 Dn e: IF IMT (Liur0< >Lirn THEM 32 IF Signɘ THEM Lirfa=Lirti+I*Sign, 133

  15. Managing Emerging Technology: Case Studies in Document Imaging Systems

    DTIC Science & Technology

    1990-01-01

    1990 Thesis/Dissertation 00 S Managing Emerging Technology : Case Studies in Document ( Imaging Systems Richard Kevin Brown AFIT Student at...older report. blank, the abstract is assumed to be unlimited. Standard Form 298 Back (Rev. 2-89) MANAGING EMERGING TECHNOLOGY : CASE STUDIES IN...Brancheau Carroll Fren el Iz e 71 &ur s Date . Brown, Richard Kevin (M.S., Management Science/ Information Systems) Managing Emerging Technology : Case

  16. The Maneuverable Atmospheric Probe (MAP), a Remotely Piloted Vehicle.

    DTIC Science & Technology

    1982-05-01

    L. Hill* Harold N. Ballard, Mike IzQuierdo, Carlos McDonalDP* S. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT . PROJECT, TASK US Army...wing ...... 14 3. Pitch gust probe protruding from top leading edge of vertical fin and Polonium 210 air ionizer on fin tip...filament temperature sensors used to determine 20-cm scale size air turbulence (left and center) and one temperature element of 2-m scale size turbulence

  17. Effect of ceramic infrastructure on the failure behavior and stress distribution of fixed partial dentures.

    PubMed

    Borba, Márcia; Duan, Yuanyuan; Griggs, Jason A; Cesar, Paulo F; Della Bona, Álvaro

    2015-04-01

    The effect of the ceramic infrastructure (IS) on the failure behavior and stress distribution of fixed partial dentures (FPDs) was evaluated. Twenty FPDs with a connector cross-section of 16 mm(2) were produced for each IS and veneered with porcelain: (YZ) Vita In-Ceram YZ/Vita VM9 porcelain; (IZ) Vita In-Ceram Zirconia/Vita VM7 porcelain; (AL) Vita In-Ceram AL/Vita VM7 porcelain. Two experimental conditions were evaluated (n = 10). For control specimens, load was applied in the center of the pontic at 0.5 mm/min until failure, using a universal testing machine, in 37°C deionized water. For mechanical cycling (MC) specimens, FPDs were subjected to MC (2 Hz, 140 N, 10(6) cycles) and subsequently tested as described for the control group. For YZ, an extra group of 10 FPDs were built with a connector cross-section of 9 mm(2) and tested until failure. Fractography and FEA were performed. Data were analyzed by ANOVA and Tukey's test (α = 0.05). YZ16 showed the greatest fracture load mean value, followed by YZ16-MC. Specimens from groups YZ9, IZ16, IZ16-MC, AL16 and AL16-MC showed no significant difference for the fracture load. The failure behavior and stress distribution of FPDs was influenced by the type of IS. AL and IZ FPDs showed similar fracture load values but different failure modes and stress distribution. YZ showed the best mechanical behavior and may be considered the material of choice to produce posterior FPDs as it was possible to obtain a good mechanical performance even with a smaller connector dimension (9 mm(2)). Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  18. Improving the Value Engineering Change Proposal Process within the U.S. Army Corps of Engineers

    DTIC Science & Technology

    1993-08-01

    his staff engineers, Lawrence Miles, to investigate the feasibility of substituting one product for another in order to increase efficiency. Miles...TO UEV!tL ARW TEM 2 rT AXL 447 -- X50~S 3. D=Iz the next few mzithe, our , qmrters will pibiisi guLc~m iff lesscwo Leavied to further ct d=eStenUmu

  19. Guidelines for the Evaluation of Visual Approach Slope Indicators,

    DTIC Science & Technology

    1984-09-01

    AD-Ai59 452 GUIDELINES FOR THE EVALUATION OF VISUAL APPROACH SLOPE j/j INDICATORS(U) AERONAUTICAL RESEARCH LABS MELBOURNE (AUSTRALIR) J MILLAR SEP 84...AND TECHNOLOGY ORGANISATION AERONAUTICAL RESEARCH LAIORATORIES AMILBOURNE. VICTOMA ’, N If) qtJ CY) SYSTEMS REPORT 32 * €GUIDELINES FOR THE...iz. . - - o..::. . .X t., AR-003-962 DEPARTMENT OF DEFENCE DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION AERONAUTICAL RESEARCH LABORATORIES

  20. A User-Oriented Management Program for Project Monitoring on a Time- Share Computer Terminal

    DTIC Science & Technology

    1978-01-01

    specific subprogram** applying only to the project R02-24. *T.H. Gauss , "A Fortran Routine to Plot Data from the NRL Job Order Status Reports," NRL...1S700 riFl .= 0, 12800 IM] 1.00 1 = 1 ? IS 159 0 0 IZ5" I DAYS a 0 (I J 1 > > IQ 111. £> J IQ U > 3> > 13 n 00 100 IF (I Z, LE

  1. Administration and Stenographic Career Ladders, AFS 702x0/A/B/C and 702X1.

    DTIC Science & Technology

    1980-04-01

    18 RECEPTIONISTS 2.4 10 57 ANALYSIS OF FIRST-TERM JOB RESPONSES The greatest economic expenditure in the management of any specialty relates to the...0 73 f ii ia _ _i i In i II - CN0 C1 C t14O. C r cjcn 0c - Q(.: CY) r.. (1)~ .40 C14 1. IT m mcq 4Cq itc ic c c I Iz In~ 0 C n w- E- C- -4 z U4 ) C

  2. Commercial Aircraft Noise Definition - L1011 Tristar. Volume 1

    DTIC Science & Technology

    1974-09-01

    eat tao twaice dwtatiozws betueen the In db dwna pulntt of t$* tosvai~ rv pereied noise Ivu tit* histars e ah*~n cnii~ta~ n~ 4kcrojtonc,- %vivenr~ie a...apu ~t zmf tltittsk. tz vaw rozten *, plin 4ov-, trsv .*Lgai* ie P04Sed to �w AOý- prtht rOutt tar %=e izý4 clcttatlre tiate alaft’ the f~lwe.t jatt

  3. Vibrational Relaxation of DF (v = 1-4) in D2, H2, N2, HF, and CO2

    DTIC Science & Technology

    1980-01-15

    ft let t C nnfo b*1 --GPM)!I I ii, KEY tOROS (Cnsbw ren Pee# Vi04 itncy end ifdlfr ~IZ Y bleeP ntbm) Ch,!micp~l Lazier Vibrational Deactivation -j...rates of the test gases were measured with rotating bal flowmeters calibrated by pressure-rise measuremets in a standard volume. The DF flow was regulated

  4. Letters

    NASA Astrophysics Data System (ADS)

    1998-12-01

    Beer's Law: The Real Hazards by S. R. Logan Re: article by M. A. Muyskens and E. T. Sevy The author replies Photodimerization of Maleic Anhydride by Zhijun Zhang Re: article by D. Todd and M. Pickering (J. Chem. Educ. 1988, 65, 1100) Qual from a Different Viewpoint by Francisco J. Arnáiz Re: article by M. Laing (J. Chem. Educ. 1993, 70, 666)

  5. Nonmetallic Inclusions in HSLA Steel Weldments

    DTIC Science & Technology

    1989-12-01

    lowering the DBTT . Nickel prevents the hot shortness phenomenon often observed in copper-bearing steels . Nickel is also an austenite stabilizer. By lowering... STEEL WELDMENTS by Brent A. Douglas December, 1989 Thesis Advisor Alan G. Fox Approved for public release; distribution is unlimited. 90 ,-. S...ACCESSION NO. II. TITLE (Incude Security Claw fication) Nonmetallic Inclusions In HSLA Steel Weldments IZ. PERSONAL AUTHOR(S) Douglas, Brent A. 138

  6. A Plasma Ultraviolet Source for Short Wavelength Lasers.

    DTIC Science & Technology

    1986-03-10

    Magnetoplasma Compressions", G. N . Kashnikov, V. K. Orlov, A. N . Panin, A. K. Piskunov and V. A. Reznikov, Sov. J. Quantum Electron. 10, 1193 (1983...i...i -..,:- . m.:...,o -,., .. .._._ _, ., -._ _-> .... ,:: , --.,..-, .: - -- r -’ - N q- I. I T .1 - 7 --- r...DOCUMENTATIONPAGE_ BEFORE COMPLETING FORM I. REPORT NUMBER 2. GOVT ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER AP.-OS7’a I IZ. G ASN/A N /A 4. TITLE (and Subtitle

  7. Time-Dependent Environmental Behavior of Graphite/Epoxy Composites

    DTIC Science & Technology

    1980-05-01

    moisture con- tent at two different humidities) conditions. Coupons for dry tests were initally desiccated for several days at moderately Pievated...tned to use 464 0 K (375 0 F) as our highest dry test temperature. After conducting some early testing at that temperature and experiencing various...li1ieI Iz j For dry tests , an oven was placed about the fixture, with a tray of desiccant, and the temperature was continuousivy ,oni- tored by a

  8. Effect of Imaging Powders on the Bond Strength of Resin Cement

    DTIC Science & Technology

    2016-09-19

    composite , metal or ceramic restorations. Self-adhesive resin cements do not require a separate adhesive or etchant and appear to have a major benefit...compared to more traditional resin cements due to their simplicity of application. Relatively little information exists about the composition and...Strength of Resin Cement" is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner. #lIZ Christopher R

  9. An Analysis of Healthcare Provider Productivity in Selected Clinical Services at Moncrief Army Community Hospital

    DTIC Science & Technology

    1990-08-13

    basis of this study. Serway (1987) suggests several productivity indicators to include: 1. FTEs per adjusted occupied bed. 2. Total operating expense...392). Note that Serway relies heavily on the kind of dollar oriented measures of output that are discouraged by Reiling, Owens, Choich, Ford and...IzComparisons for Physicians and Nurse Practitioners. Medical Care. 20(2), 143-153.z Serway , G., Strum, D., & Haug, W. (1987). Alternative Indicators for

  10. Archaeological Investigations at Site 45-DO-211, Chief Joseph Dam Project, Washington.

    DTIC Science & Technology

    1984-01-01

    tool manufacturing techniques. Journal of Field Archaeology 2:125-131. Franklin, J.F., and C.T. Dyrness 1973 Natural vegetation of Oregon and Washington...Figure 3-2. Edge angle distributions of tools classified as wear only and wear and manufacture .... ................. .... 70 Figure 3-3. Definition of...modified rocks, and 71 nonlithic and historic artifacts was recovered. The lithic assemblage Includes 386 worn and/or manufactured tools . REPORT ORGM IZ

  11. DARPA - Advanced Composite Materials Annual Presentation Held in Gainesville, Florida on 19-20 November 1992

    DTIC Science & Technology

    1992-11-20

    12:00-1:30 Lunch 1:30 Informal Subgroup Discussions and Tour of the Facilities .... APPROVED FD?, P’ ,TLIC PELEAS - "’ DISIRiBuTO.. U Li,6raD Avail...110Iz TEMPERATURE (°C) I r I A 0.Ig .I ... I--A Ile II IT 0. I. I I I I. S102 - AV ) 3 PHASE DIAGRAM 2020 UMOLE % A12%3 0 020 40 Go o 100 2000. ML_

  12. Indiana Air National Guard, 122 Tactical Wing, Fort Wayne, Indiana. Installation Restoration Program

    DTIC Science & Technology

    1994-01-01

    Quality Assurance/Quality Control £ RD Remedial Design RfC Reference Concentration FortWayne/Sl Report/December 10, 1993/10: 20am xii 7 I List of Acronyms...metal] - the reported value was rejected because spike recovery is outside the control limits. 3-61 z .. ll! CE’ ’llll -S 011 Iz I Mo z co Pt Z eg?.I

  13. Integrated analysis of zone-specific protein and metabolite profiles within nitrogen-fixing Medicago truncatula-Sinorhizobium medicae nodules

    DOE PAGES

    Ogden, Aaron J.; Gargouri, Mahmoud; Park, JeongJin; ...

    2017-07-10

    Symbiotic nitrogen fixation (SNF) between rhizobia and legumes requires metabolic coordination within specialized root organs called nodules. Nodules formed in the symbiosis between S. medicae and barrel medic (M. truncatula) are indeterminate, cylindrical, and contain spatially distinct developmental zones. Bacteria in the infection zone II (ZII), interzone II-III (IZ), and nitrogen fixation zone III (ZIII) represent different stages in the metabolic progression from free-living bacteria into nitrogen fixing bacteroids. To better understand the coordination of plant and bacterial metabolism within the nodule, we used liquid and gas chromatography coupled to tandem mass spectrometry (MS) to observe protein and metabolite profilesmore » representative of ZII, IZ, ZIII, whole-nodule, and primary root. Our MS-based approach confidently identified 361 S. medicae proteins and 888 M. truncatula proteins, as well as 160 metabolites from each tissue. The data are consistent with several organ- and zone-specific protein and metabolite localization patterns characterized previously. Here, we used our comprehensive dataset to demonstrate how multiple branches of primary metabolism are coordinated between symbionts and zones, including central carbon, fatty acid, and amino acid metabolism. For example, M. truncatula glycolysis enzymes accumulate from zone I to zone III within the nodule, while equivalent S. medicae enzymes decrease in abundance. We also show the localization of S. medicae's transition to dicarboxylic acid-dependent carbon metabolism within the IZ. The spatial abundance patterns of S. medicae fatty acid (FA) biosynthesis enzymes indicate an increased demand for FA production in the IZ and ZIII as compared to ZI. Our observations provide a resource for those seeking to understand coordinated physiological changes during the development of SNF.« less

  14. Effect of the microstructure on the lifetime of dental ceramics

    PubMed Central

    Borba, Márcia; de Araújo, Maico D.; Fukushima, Karen A.; Yoshimura, Humberto N.; Cesar, Paulo F.; Griggs, Jason A.; Della Bona, Álvaro

    2011-01-01

    Objectives To evaluate the effect of the microstructure on the Weibull and slow crack growth (SCG) parameters and on the lifetime of three ceramics used as framework materials for fixed partial dentures (FPDs) (YZ - Vita In-Ceram YZ; IZ - Vita In-Ceram Zirconia; AL - Vita In-Ceram AL) and of two veneering porcelains (VM7 and VM9). Methods Bar-shaped specimens were fabricated according to the manufacturer’s instructions. Specimens were tested in three-point flexure in 37°C artificial saliva. Weibull analysis (n=30) and a constant stress-rate test (n=10) were used to determine the Weibull modulus (m) and SCG coefficient (n), respectively. Microstructural and fractographic analyses were performed using SEM. ANOVA and Tukey’s test (α=0.05) were used to statistically analyze data obtained with both microstructural and fractographic analyses. Results YZ and AL presented high crystalline content and low porosity (0.1–0.2%). YZ had the highest characteristic strength (σ0) value (911 MPa) followed by AL (488 MPa) and IZ (423 MPa). Lower σ0 values were observed for the porcelains (68–75 MPa). Except for IZ and VM7, m values were similar among the ceramic materials. Higher n values were found for YZ (76) and AL (72), followed by IZ (54) and the veneering materials (36–44). Lifetime predictions showed that YZ was the material with the best mechanical performance. The size of the critical flaw was similar among the framework materials (34–48 µm) and among the porcelains (75–86 µm). Significance The microstructure influenced the mechanical and SCG behavior of the studied materials and, consequently, the lifetime predictions. PMID:21536324

  15. Oxidative modification of guanine bases initiated by oxyl radicals derived from photolysis of azo compounds.

    PubMed

    Shao, Jie; Geacintov, Nicholas E; Shafirovich, Vladimir

    2010-05-20

    Oxidative damage to guanine bases initiated by photolysis of the water-soluble radical generator 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) has been investigated by laser kinetic spectroscopy. In the neutral oxygenated aqueous solutions, 355 nm laser flash photolysis of AAPH generates a whole spectrum of free radicals including 2-amidinoprop-2-peroxyl (ROO(*)), 2-amidinoprop-2-oxyl (RO(*)), and superoxide (O(2)(*-)) radicals. These oxyl radicals with negligible absorption in a near UV-visible range were monitored in the reactions leading to the products with characteristic absorption spectra. This approach reveals that RO(*) radicals induce fast one-electron oxidation of 2'-deoxyguanosine (dG) to form guanine neutral radicals, dG(-H)(*). In contrast, ROO(*) radicals do not react at observable rates with dG. The O(2)(*-) radicals were detected using a classical test reaction with tetranitromethane to form nitroform. The major pathway for formation of the end-products of guanine oxidation is the combination of the G(-H)(*) and O(2)(*-) radicals to form 2,5-diamino-4H-imidazolone (Iz). This mechanism was confirmed by analysis of the end-products produced by oxidation of two substrates: (1) the guanosine derivative 2',3',5'-tri-O-acetylguanosine (tri-O-Ac-G) and (2) the 5'-d(CCATCGCTACC) sequence. The major products isolated by HPLC and identified by mass spectrometry methods were the tri-O-Ac-Iz and 5'-d(CCATC[Iz]CTACC products.

  16. Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon

    PubMed Central

    Liu, Yuan-Hsuan; Tsai, Jin-Wu; Chen, Jia-Long; Yang, Wan-Shan; Chang, Pei-Ching; Cheng, Pei-Lin; Turner, David L.; Yanagawa, Yuchio; Wang, Tsu-Wei; Yu, Jenn-Yah

    2017-01-01

    During development, cortical interneurons generated from the ventral telencephalon migrate tangentially into the dorsal telencephalon. Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays important roles in the developing telencephalon, whether Ascl1 regulates tangential migration remains unclear. Here, we found that Ascl1 promoted tangential migration along the ventricular zone/subventricular zone (VZ/SVZ) and intermediate zone (IZ) of the dorsal telencephalon. Distal-less homeobox 2 (Dlx2) acted downstream of Ascl1 in promoting tangential migration along the VZ/SVZ but not IZ. We further identified Eph receptor B2 (Ephb2) as a direct target of Ascl1. Knockdown of EphB2 disrupted the separation of the VZ/SVZ and IZ migratory routes. Ephrin-A5, a ligand of EphB2, was sufficient to repel both Ascl1-expressing cells in vitro and tangentially migrating cortical interneurons in vivo. Together, our results demonstrate that Ascl1 induces expression of Dlx2 and Ephb2 to maintain distinct tangential migratory routes in the dorsal telencephalon. PMID:28276447

  17. Molecules and mechanisms that regulate multipolar migration in the intermediate zone.

    PubMed

    Cooper, Jonathan A

    2014-01-01

    Most neurons migrate with an elongated, "bipolar" morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone (IZ) of the neocortex they become "multipolar". Multipolar cells extend and retract cytoplasmic processes in different directions and move erratically-sideways, up and down. Multipolar cells extend axons while they are in the lower half of the IZ. Remarkably, the cells then resume radial migration: they reorient their centrosome and Golgi apparatus towards the pia, transform back to bipolar morphology, and commence locomotion along radial glia (RG) fibers. This reorientation implies the existence of directional signals in the IZ that are ignored during the multipolar stage but sensed after axonogenesis. In vivo genetic manipulation has implicated a variety of candidate directional signals, cell surface receptors, and signaling pathways, that may be involved in polarizing multipolar cells and stabilizing a pia-directed leading process for radial migration. Other signals are implicated in starting multipolar migration and triggering axon outgrowth. Here we review the molecules and mechanisms that regulate multipolar migration, and also discuss how multipolar migration affects the orderly arrangement of neurons in layers and columns in the developing neocortex.

  18. Molecules and mechanisms that regulate multipolar migration in the intermediate zone

    PubMed Central

    Cooper, Jonathan A.

    2014-01-01

    Most neurons migrate with an elongated, “bipolar” morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone (IZ) of the neocortex they become “multipolar”. Multipolar cells extend and retract cytoplasmic processes in different directions and move erratically—sideways, up and down. Multipolar cells extend axons while they are in the lower half of the IZ. Remarkably, the cells then resume radial migration: they reorient their centrosome and Golgi apparatus towards the pia, transform back to bipolar morphology, and commence locomotion along radial glia (RG) fibers. This reorientation implies the existence of directional signals in the IZ that are ignored during the multipolar stage but sensed after axonogenesis. In vivo genetic manipulation has implicated a variety of candidate directional signals, cell surface receptors, and signaling pathways, that may be involved in polarizing multipolar cells and stabilizing a pia-directed leading process for radial migration. Other signals are implicated in starting multipolar migration and triggering axon outgrowth. Here we review the molecules and mechanisms that regulate multipolar migration, and also discuss how multipolar migration affects the orderly arrangement of neurons in layers and columns in the developing neocortex. PMID:25452716

  19. Removal of tetrachloroethylene in an anaerobic column bioreactor.

    PubMed

    Noftsker, C; Watwood, M E

    1997-09-01

    Removal of tetrachloroethylene (perchloroethylene; C2Cl4) by microbial consortia from two sites with different C2Cl4 exposure histories was examined in a bench-scale anaerobic column bioreactor. It was hypothesized that optimal removal would be observed in the reactor packed with sediments having an extensive exposure history. Microbial consortia were enriched from hyporheic-zone (HZ) sediments from the Portneuf aquifer near Pocatello, Idaho, and from industrial-zone (IZ) sediments from a highly contaminated aquifer in Portland, Oregon. Lactate and acetate were the electron donors during experiments conducted over 9 and 7 months for HZ and IZ sediments, respectively. In the HZ bioreactor, the retention time ranged from 31 h to 81 h, and inlet C2Cl4 concentrations ranged from 0.1 ppm to 1.0 ppm. Dechlorination of C2Cl4 averaged 60% and reached a maximum of 78%. An increase in C:N from 27:1 to 500:1 corresponded to an 18% increase in removal efficiency. Trichloroethylene production corresponded to decreased effluent C2Cl4; further intermediates were not detected. In the IZ bioreactor, the retention time varied from 34 h to 115 h; the inlet C2Cl4 concentration was 1.0 ppm. C2Cl4 removal averaged 70% with a maximum of 98%. Trichloroethylene and cis-dichloroethylene were detected in the effluent. Increases in C:N from 50:1 to 250:1 enhanced dechlorination activity.

  20. Characterization of the motor units of the external anal sphincter in pregnant women with multichannel surface EMG.

    PubMed

    Cescon, Corrado; Raimondi, Eleonora Ester; Začesta, Vita; Drusany-Starič, Kristina; Martsidis, Konstantinos; Merletti, R

    2014-08-01

    Locating the innervation zones (IZs) of the external anal sphincter (EAS) is helpful to obstetricians to identify areas particularly vulnerable to episiotomy in pregnant women. The aim was to investigate the motor unit (MU) properties of the EAS during voluntary contractions. Electromyographic signals were detected, from 478 pregnant women, by means of an intra-anal cylindrical probe carrying a circumferential array of 16 electrodes. The signals were decomposed into the constituent MU action potential trains and 5,947 templates were extracted and analyzed in order to identify the IZ position. MUs innervated at one end are concentrated in the dorsal portion of the sphincter, while MUs innervated in the middle are distributed symmetrically in the left and right portions of the EAS. The angular propagation velocity was estimated for each MU resulting in 260 ± 45 rad/s, corresponding to 1.8 m/s on the probe surface and to about 4 m/s at a radial depth of 10 mm from the probe surface. A novel method for identification and classification of MUs of the EAS is proposed and applied to a large-scale study. It is possible to distinguish MUs of the EAS in a minimally invasive way and identify their IZs. This information should be used to plan episiotomies and minimize risks of EAS denervation.

  1. THE GALACTIC O-STAR SPECTROSCOPIC SURVEY. I. CLASSIFICATION SYSTEM AND BRIGHT NORTHERN STARS IN THE BLUE-VIOLET AT R {approx} 2500

    SciTech Connect

    Sota, A.; Maiz Apellaniz, J.; Alfaro, E. J.; Barba, R. H.; Morrell, N. I.; Gamen, R. C.

    2011-04-01

    We present the first installment of a massive spectroscopic survey of Galactic O stars, based on new, high signal-to-noise ratio, R {approx} 2500 digital observations from both hemispheres selected from the Galactic O-Star Catalog of MaIz Apellaniz et al. and Sota et al. The spectral classification system is rediscussed and a new atlas is presented, which supersedes previous versions. Extensive sequences of exceptional objects are given, including types Ofc, ON/OC, Onfp, Of?p, Oe, and double-lined spectroscopic binaries. The remaining normal spectra bring this first sample to 184 stars, which is close to complete to B = 8 and north of {delta} = -20{sup 0} and includes all of the northern objects in MaIz Apellaniz et al. that are still classified as O stars. The systematic and random accuracies of these classifications are substantially higher than previously attainable, because of the quality, quantity, and homogeneity of the data and analysis procedures. These results will enhance subsequent investigations in Galactic astronomy and stellar astrophysics. In the future, we will publish the rest of the survey, beginning with a second paper that will include most of the southern stars in MaIz Apellaniz et al.

  2. Concordance of the location of the innervation zone of the tibialis anterior muscle using voluntary and imposed contractions by electrostimulation.

    PubMed

    Guzmán-Venegas, R A; Bralic, M P; Cordero, J J; Cavada, G; Araneda, O F

    2016-04-01

    The innervation zone (IZ) corresponds to the location of the neuromuscular junctions. Its location can be determined by using arranged surface linear electrode arrays. Typically, voluntary muscle contractions (VC) are used in this method. However, it also may be necessary to locate the IZ under clinical conditions such as spasticity, in which this type of contraction is difficult to perform. Therefore, contractions imposed by electrostimulation (ES) can be an alternative. There is little background comparing the locations of IZ obtained by two different types of contractions. Evaluate the concordance between using voluntary and imposed contractions from electrostimulation in order to determine the location of the innervation zone of the tibialis anterior muscle in healthy volunteers. The tibialis anterior (TA) muscle of sixteen volunteers (men: 8; women: 8; age: 22.1±1.4years, weight: 61.6±7.5kg, height: 167.1±7.5cm) were evaluated using a linear electrode array. The IZ of the TA muscle was located using two types of muscle contractions, voluntary (10% MVC) and imposed contractions by ES. The concordance between both conditions was evaluated using the Bland-Altman method and the concordance correlation coefficient (CCC). The analyses were applied to the absolute and relative positions to the length of an anatomical landmark frame. CCC for absolute position was 0.98 (p<0.0001, 95% CI [0.98-1.00], and CCC for relative positions also was 0.98 (p<0.0001, 95% CI [0.97-1.00]). The Bland-Altman analysis for absolute data showed an average difference of -0.63mm (SD: 4.1). Whereas, for adjusted data, the average difference was -0.20% (SD: 1.2). The power of the results, based on absolute data, was 98%, whereas for relative data, 82%. In healthy volunteers, there was a substantially concordance between the location of the IZ of the TA muscle derived from using contractions imposed by ES and the location derived from using VC. Copyright © 2016 Elsevier Ltd. All rights

  3. Behavior of (137)Cs in ponds in the vicinity of the Fukushima Dai-ichi nuclear power plant.

    PubMed

    Wakiyama, Yoshifumi; Konoplev, Alexei; Wada, Toshihiro; Takase, Tsugiko; Byrnes, Ian; Carradine, Matthew; Nanba, Kenji

    2017-08-08

    (137)Cs activity concentration in the water of four ponds, Suzuuchi (SU), Funasawa (FS), Inkyozaka (IZ), and Kashiramori (KM), that are within 10 km of the Fukushima Dai-ichi nuclear power plant were observed from April 2015 to August 2016. (137)Cs inventories in soils surrounding SU, FS, IZ, and KM were 6.4, 2.9, 2.1, and 0.9 MBq m(-2), respectively. (137)Cs inventories in the bottom sediments of SU, FS, IZ, and KM were 13, 8.9, 1.6, and 1.1 MBq m(-2), respectively. Higher (137)Cs inventories in bottom sediment than those of soil in SU and FS suggest that (137)Cs was delivered to and accumulated in these ponds. Mean total (137)Cs activity concentrations in SU, FS, IZ, and KM were 41, 13, 9.5, and 1.4 Bq L(-1), respectively. Particulate (137)Cs concentration accounted for 71-90% of total (137)Cs in the water samples, on average. The mean distribution coefficient, Kd, in SU, FS, IZ, and KM was 1.3 × 10(5), 2.1 × 10(5), 1.7 × 10(5), and 6.2 × 10(5) L kg(-1), respectively. These Kd values were higher than the Kd values observed in the Chernobyl area by 1-2 orders of magnitude. Although no significant decreasing trends were found, dissolved (137)Cs activity concentration tended to be low during winter in all four ponds. Dissolved (137)Cs activity concentrations were proportional to K(+) and DOC concentrations in all the ponds. The results from principal component analysis performed for (137)Cs activity concentration and water chemistry data sets suggested that there were different mechanisms behind variability of dissolved (137)Cs activity concentrations for each pond. Continuous monitoring is required to reveal temporal trends in (137)Cs activity concentrations of these waters and controlling factors of such in closed water systems in Fukushima. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Influence of sodalite zeolite infiltration on the coefficient of thermal expansion and bond strength of all-ceramic dental prostheses.

    PubMed

    Naji, Ghassan Abdul-Hamid; Omar, Ros Anita; Yahya, Rosiyah

    2017-03-01

    In all-ceramic systems, a high incidence of veneer chip-off has been reported in clinical studies. Coefficient of thermal expansion (CTE) behaviour is one of the factors that may increase residual stress in the interface and influence the veneer/core bond strength. Therefore, this study aimed to evaluate the effect of sodalite zeolite-infiltration on the CTE behaviour and bond strength of different all-ceramic prostheses. The case-study groups were synthesized sodalite zeolite-infiltrated alumina (IA-SOD) and synthesized sodalite zeolite-infiltrated zirconia-toughened alumina (ZTA) (IZ-SOD), while the control groups were glass-infiltrated alumina (IA-glass) and glass-infiltrated ZTA (IZ-glass). Forty cylindrical-shaped samples measuring 5 mm in diameter and 10 mm in height were tested for CTE using a thermo-mechanical analyser machine, and forty disc-shaped ceramic samples measuring 12 mm in diameter and 1.2 ± 0.2 mm in thickness were prepared using specially designed stainless steel split mould and veneered by cylinder-shaped (2 mm high × 2 mm diameter) low-fusing porcelain (Vita VM7). The veneer/core samples were sintered and tested for shear bond strength using a high precision universal testing machine. Scanning electron microscope, stereo microscope, atomic force microscope, and energy-dispersive X-ray spectroscopy were used to investigate the structural characteristics of samples at the fracture surface. The collected data were analyzed with a one-way ANOVA and Tukey HSD test (α=.05). IZ-SOD revealed highest CTE and shear bond strength values, while the IA-glass revealed the lowest values than the other groups. There was no significant difference in CTE and bond strength among IZ-SOD, IA-SOD and IZ-glass samples (p>0.05). The experimental SOD zeolite-infiltrated samples revealed higher CTE mismatch and bond strength along with a more favourable mode of failure than did the commercial glass-infiltrated samples. Sandblast technique is considered as effective

  5. Verb and noun deficits in stroke-induced and primary progressive aphasia: The Northwestern Naming Battery().

    PubMed

    Thompson, Cynthia K; Lukic, Sladjana; King, Monique C; Mesulam, M Marsel; Weintraub, Sandra

    2012-05-01

    BACKGROUND: Word class naming deficits are commonly seen in aphasia resulting from stroke (StrAph) and primary progressive aphasia (PPA), with differential production of nouns (objects) and verbs (actions) found based on StrAph type or PPA variant for some individuals. Studies to date, however, have not compared word class naming (or comprehension) ability in the two aphasic disorders. In addition, there are no available measures for testing word class deficits, which control for important psycholinguistic variables across language domains. This study examined noun and verb production and comprehension in individuals with StrAph and PPA using a new test, the Northwestern Naming Battery (NNB; Thompson & Weintraub, experimental version), developed explicitly for this purpose. In addition, we tested verb type effects, based on verb argument structure characteristics, which also is addressed by the NNB. METHOD: Fifty-two participants with StrAph (33 agrammatic, Broca's (StrAg); 19 anomic (StrAn)) and 28 PPA (10 agrammatic (PPA-G); 14 logopenic (PPA-L); 4 semantic (PPA-S)) were included in the study. Nouns and verbs were tested in the Confrontation Naming and Auditory Comprehension subtests of the NNB, with scores used to compute noun to verb ratios as well as performance by verb type. Performance patterns within and across StrAph and PPA groups were then examined. The external validity of the NNB also was tested by comparing (a) NNB Noun Naming scores to the Boston Naming Test (BNT; Kaplan, Goodglass, & Weintraub, 1983) and Western Aphasia Battery (WAB-R, Kertesz, 2007) Noun Naming subtest scores, (b) NNB Verb Naming scores to the Boston Diagnostic Aphasia Examination (BDAE; Goodglass, Kaplan & Barresi, 2001) Action Naming score (for StrAph participants only), and (c) NNB Comprehension subtest scores to WAB-R Auditory Comprehension subtest scores. OUTCOMES AND RESULTS: Both agrammatic (StrAg and PPA-G) groups showed significantly greater difficulty producing verbs

  6. Design of a helix-bundle cross-link: NMR and UV-visible spectroscopic analyses and molecular modeling of ring-oxidized retinals.

    PubMed

    Williams, T C; Mani, V

    1991-03-19

    In order to generate potential chemical cross-links for studying the chromophore binding site of bacteriorhodopsin and related helix-bundle proteins, MnO2 was used to oxidize all-trans-retinal's ring moiety. The structures and solution conformations of three ring-oxidized retinal analogues have been determined by using UV-visible absorption and 1H and 13C NMR spectroscopies, primarily with regard to (i) the introduction of a functional group at the ring end of the chromophore, (ii) the retention of the all-trans geometry of the polyenal side chain, and (iii) the torsional angle of the ring-polyenal bond. Analyses of their UV-visible absorption spectral parameters (lambda max, epsilon max, and vibrational fine structure) and NMR spectral parameters (1H-1H coupling constants, 1H and 13C NMR chemical shifts, and 1H homonuclear Overhauser effects) indicated the 4-oxo and the 2,3-dehydro-4-oxo derivatives both possess the twisted 6-s-cis conformation adopted by most six-membered ring analogues of retinal in solution or crystal. However, the alpha-dioxocyclopentenyl analogue exists in solution predominantly (70-80%) as the planar 6-s-trans conformer, similar to violerythrine chromophore analogues. In order to identify the minor solution forms, molecular modeling and geometry optimizations using the semiempirical molecular orbital method AM1 defined two additional symmetry-related minima at +/- 30-40 degrees in its C6-C7 torsional energy profile. Because the chromophores of bacterio- and halorhodopsins and sensory rhodopsins are bound as the 6-s-trans conformer [Harbison, G.S., Smith, S.O., Pardoen, J.A., Courtin, J.M.L., Lugtenburg, J., Herzfeld, J., Mathies, R.A., & Griffin, R.G. (1985) Biochemistry 24, 6955-6962; Baselt, D.R., Fodor, S.P.A., van der Steen, R., Lugtenburg, J., Bogomolni, R.A., & Mathies, R.A. (1989) Biophys. J. 55, 193-196], we suggest that the cyclopentenyl analogue's alpha-diketo function may be favorably positioned within the binding pocket and

  7. Silabutadienes. Internal rotations and pi-conjugation. A density functional theory study.

    PubMed

    Xi, Hong-Wei; Karni, Miriam; Apeloig, Yitzhak

    2008-12-18

    The potential energy surfaces (PESs) for internal rotation around the central single bond of nine silabutadienes, which include all possible mono-, di-, tri-, and tetrasilabutadienes, are investigated computationally by using DFT with the B3LYP functional and the 6-311+G(d,p) basis set. For 1-silabutadiene (3), 2-silabutadiene (4), 1,4-disilabutadiene (5), 2,3-disilabutadiene (6), and 1,3-disilabutadiene (7), the s-trans rotamer is the most stable. For 1,2-disilabutadiene (8), 1,2,3-trisilabutadiene (9), and 1,2,4-trisilabutadiene (10), all having a trans-bent SiSi double bond, the most stable conformers are those having an antiperiplanar (ap) structure. For tetrasilabutadiene (11), the global minimum is the gauche rotamer. The internal rotation barriers (RB) (relative to the global minimum) follow the order (kcal/mol) 5 (10.0) > 3 (7.4) > 1,3-butadiene (12, (6.6)) > 10 (4.9) > or = 7 (4.4) > or = 4 (4.0) approximately = 8 (3.9) > 9 (2.7) approximately = 6 (2.6) > 11 (2.4). The barriers are slightly smaller at CCSD(T)/cc-PVTZ, but the trend remains the same. The size of the rotation barrier is mainly dictated by the length of the central single bond; that is, it is the largest for dienes with the shorter C-C central bond (5, 3, and 12), and it is smaller for dienes with the longer Si-C and Si-Si central bonds. The strength of pi-conjugation in the s-trans conformers of silabutadienes was estimated by resonance stabilization energies (RE) calculated by using the Natural Bond Orbital (NBO) and Block Localized Wave function (BLW) methods and bond separation equations. A linear correlation is found between the barrier heights for internal rotation and pi-conjugation energies. The calculated RBs are significantly smaller than the corresponding REs, indicating that pi-resonance energies are not the only factor that dictate the RB, and therefore, RBs, although suitable for estimating trends in pi-conjugation in a series of compounds, cannot be used for estimating absolute

  8. Theoretical and applied studies of rhodopsin and bacteriorhodopsin

    NASA Astrophysics Data System (ADS)

    Tallent, Jack R.

    Part I. The conformational and electronic properties of the 12-s-cis and 12-s-trans conformers of 11-cis retinal are analyzed. Our models confirm that the 12-s-cis isomer is more stable in vacuum and the 12-s-trans conformer is more stable in polar and nonpolar solvent environments due to dispersive and electrostatic interactions. Electronic analysis indicates that the features in the absorption spectrum are due to a complex set of overlapping transitions. Assignments are made for all four band systems. Ground- and excited-state surfaces connecting rhodopsin and bathorhodopsin along the F11,12 dihedral reaction path are partially adiabatically mapped. Forward and reverse photochemistry is simulated via molecular dynamics. The activated complex is reached in ˜375 fs following excitation. Best results for quantum yields and product formation times are obtained by including both dynamic and phased (partitioned) nonadiabatic coupling: FR→B=0.698;tR→B =1.360 ps; FB→R=0.521;tB→R =1.628 ps. The lower quantum yield of the B → R isomerization is due to a sign change in the nonadiabatic coupling term at F11,12 = 92° and to the rapid arrival of the trajectory into the activated complex which prevents equilibration of the excited state and lowers the dynamic coupling term. The Sn←S1 excited singlet state spectrum is calculated as a function of time following excitation of rhodopsin. A model of thermal noise in rods is proposed whereby thermal isomerization occurs when the retinal Schiff base is unprotonated. This model accounts for the low activation energy of 23--27 kcal mol-1 and is supported by both molecular models and experimental measurements. Part II. A prototype holographic memory is described which demonstrates simultaneous storage and retrieval of ten holographic images in the same volume of a bacteriorhodopsin(BR)/polyvinylalcohol(PVA) film. The suitability of BR as a volume holographic memory medium is discussed. Photochemistry in dried PVA films of

  9. Ultrafast dynamics and excited state spectra of open-chain carotenoids at room and low temperatures.

    PubMed

    Niedzwiedzki, Dariusz; Koscielecki, Jeremy F; Cong, Hong; Sullivan, James O; Gibson, George N; Birge, Robert R; Frank, Harry A

    2007-05-31

    , for the longest molecule in the series, spirilloxanthin, the experiments and a detailed quantum computational analysis reveal the presence of two S* states associated with relaxed S1 (2(1)Ag-) conformations involving nearly planar 6-s-cis and 6-s-trans geometries. We propose that in polar solvents, the ground state of spirilloxanthin takes on a corkscrew conformation that generates a net solute dipole moment while decreasing the cavity formation energy. Upon excitation and relaxation into the S1 (2(1)Ag-) state, the polyene unravels and flattens into a more planar geometry with comparable populations of 6-s-trans and 6-s-cis conformations.

  10. Nutrient and particle load estimates to Lake Tahoe (CA-NV, USA) for Total Maximum Daily Load establishment.

    PubMed

    Sahoo, G B; Nover, D M; Reuter, J E; Heyvaert, A C; Riverson, J; Schladow, S G

    2013-02-01

    The Lake Tahoe Total Maximum Daily Load (TMDL) requires detailed methodologies to identify sources of flows and pollutants (particles and nutrients) for estimating time-variant loads as input data for the Lake Tahoe clarity model. Based on field data and a modeling study, the major sources of pollutant loads include streams (three subdivisions of this category are urban, nonurban, and stream channel erosion), intervening zones (IZs) (two subdivisions of this category are urban and nonurban), atmosphere (wet and dry), groundwater and shoreline erosion. As Lake Tahoe remains well oxygenated year-round, the contribution of internal loading from the bottom sediments was considered minor. A comprehensive quantitative estimate for fine particle number (< 16 μm diameter) and nutrient (nitrogen and phosphorus) loading is presented. Uncertainties in the estimation of fine particle numbers and nutrients for different sources are discussed. Biologically available phosphorus and nitrogen were also evaluated. Urban runoff accounted for 67% of the total fine particle load for all sources making it the most significant contributor although total urban runoff was only 6%. Non-urban flows accounted for 94% of total upland runoff, but the nitrogen, phosphorus and fine sediment loadings were 18%, 47% and 12%, respectively of the total loadings. Atmospheric nitrogen, phosphorus, and fine particle loadings were approximately 57%, 20%, and 16%, respectively of the total loading. Among streams and IZs, IZ 8000, Upper Truckee River, Trout Creek, Blackwood Creek, and Ward Creek are the top fine particle, nitrogen and phosphorus contributors. The relative percentage contribution of inorganic fine particles from all sources based on annual average for the period 1994-2008 on size classes 0.5-1, 1-2, 2-4, 4-8, and 8-16 μm are 73%, 19%, 5%, 2%, and 1%, respectively. These results suggest clear priorities for resource managers to establish TMDL on sources and incoming pollutants and

  11. Comparison of phenotypic traits and genetic relatedness of Salmonella enterica subspecies arizonae isolates from a colony of ridgenose rattlesnakes with osteomyelitis.

    PubMed

    Bemis, David A; Owston, Michael A; Lickey, Adrienne L A; Kania, Stephen A; Ebner, Paul; Rohrbach, Barton W; Ramsay, Edward C

    2003-07-01

    Reptiles are well-known sources of human Salmonella infections; however, little is known about the ability of Salmonella to cause disease in reptiles. Thirty-seven isolates of Salmonella enterica subspecies arizonae (S. arizonae) were obtained from retrospective and prospective studies of a closed colony of ridgenose rattlesnakes (Crotalus willardi) with osteomyelitis. All isolates (N = 7) from bone lesions were of a single serotype, 56:z4,z23, and this serotype was found on only 1 occasion among 8 other serotypes isolated from 21 cloacal and intestinal samples. The remainder (N = 7) of serotype 56:z4,z23 isolates were from other extraintestinal sites, including liver, ovary, blood, and testis. S. arizonae isolates were susceptible to most antimicrobials, and plasmid profiles did not correlate with serotype or antimicrobial resistance. Isolates of the 56:z4,z23 serotype (N = 14) formed a tight cluster with 95% similarity by XbaI macrorestriction analysis. Individual isolates of serotypes, 56:z4,z23, 38:(k)-z35, and 48:i-z invaded HeLa cells but an isolate of serotype 50:r-z did not. The same individual isolates of serotype 56:z4,z23 and 48:i-z also invaded viper heart cells. The Salmonella InvA gene was detected by polymerase chain reaction (PCR) in all S. arizonae serotypes tested, including 5 serotype 56:z4,z23 isolates and individual isolates of serotypes 48:i-z and 50:r-z. A source or possible explanation for increased virulence of S. arizonae serotype 56:z4,z23 in this unique host has not been found.

  12. Oxidative Modification of Guanine Bases Initiated by Oxyl Radicals Derived From Photolysis of Azo Compounds

    PubMed Central

    Shao, Jie; Geacintov, Nicholas E.; Shafirovich, Vladimir

    2010-01-01

    Oxidative damage to guanine bases initiated by photolysis of the water-soluble radical generator 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) has been investigated by laser kinetic spectroscopy. In the neutral oxygenated aqueous solutions, 355 nm laser flash photolysis of AAPH generates a whole spectrum of free radicals including 2-amidinoprop-2-peroxyl (ROO•), 2-amidinoprop-2-oxyl (RO•), and superoxide (O2•−) radicals. These oxyl radicals with negligible absorption in a near UV – visible range were monitored in the reactions leading to the products with characteristic absorption spectra. This approach reveals that RO• radicals induce fast one-electron oxidation of 2′-deoxyguanosine (dG) to form guanine neutral radicals, dG(-H)•. In contrast, ROO• radicals do not react with observable rates with dG. The O2•− radicals were detected using a classical test reaction with tetranitromethane to form nitroform. The major pathway for formation of the end products of guanine oxidation is combination of the G(-H)• and O2•− radicals to form 2,5-diamino-4H-imidazolone (Iz). This mechanism was confirmed by analysis of the end products produced by oxidation of two substrates: (1) guanosine derivative 2′,3′,5′-tri-O-acetylguanosine (tri-O-Ac-G), and (2) the 5′-d(CCATCGCTACC) sequence. The major products isolated by HPLC and identified by mass spectrometry methods were the tri-O-Ac-Iz and 5′-d(CCATC[Iz]CTACC products. PMID:20415485

  13. Metabolic engineering of Zymomonas mobilis for 2,3-butanediol production from lignocellulosic biomass sugars

    SciTech Connect

    Yang, Shihui; Mohagheghi, Ali; Franden, Mary Ann; Chou, Yat -Chen; Chen, Xiaowen; Dowe, Nancy; Himmel, Michael E.; Zhang, Min

    2016-09-02

    To develop pathways for advanced biofuel production, and to understand the impact of host metabolism and environmental conditions on heterologous pathway engineering for economic advanced biofuels production from biomass, we seek to redirect the carbon flow of the model ethanologen Zymomonas mobilis to produce desirable hydrocarbon intermediate 2,3-butanediol (2,3-BDO). 2,3-BDO is a bulk chemical building block, and can be upgraded in high yields to gasoline, diesel, and jet fuel. 2,3-BDO biosynthesis pathways from various bacterial species were examined, which include three genes encoding acetolactate synthase, acetolactate decarboxylase, and butanediol dehydrogenase. Bioinformatics analysis was carried out to pinpoint potential bottlenecks for high 2,3-BDO production. Different combinations of 2,3-BDO biosynthesis metabolic pathways using genes from different bacterial species have been constructed. Our results demonstrated that carbon flux can be deviated from ethanol production into 2,3-BDO biosynthesis, and all three heterologous genes are essential to efficiently redirect pyruvate from ethanol production for high 2,3-BDO production in <i>Z. mobilis. The down-selection of best gene combinations up to now enabled <i>Z. mobilis to reach the 2,3-BDO production of more than 10 g/L from glucose and xylose, as well as mixed C6/C5 sugar streams derived from the deacetylation and mechanical refining process. In conclusion, this study confirms the value of integrating bioinformatics analysis and systems biology data during metabolic engineering endeavors, provides guidance for value-added chemical production in <i>Z. mobilis, and reveals the interactions between host metabolism, oxygen levels, and a heterologous 2,3-BDO biosynthesis pathway. Taken together, this work provides guidance for future metabolic engineering efforts aimed at boosting 2,3-BDO titer anaerobically.

  14. DES J0454-4448: discovery of the first luminous z ≥ 6 quasar from the Dark Energy Survey

    SciTech Connect

    Reed, S. L.; McMahon, R. G.; Banerji, M.; Becker, G. D.; Gonzalez-Solares, E.; Martini, P.; Ostrovski, F.; Rauch, M.; Abbott, T.; Abdalla, F. B.; Allam, S.; Benoit-Levy, A.; Bertin, E.; Buckley-Geer, E.; Burke, D.; Carnero Rosell, A.; da Costa, L. N.; D'Andrea, C.; DePoy, D. L.; Desai, S.; Diehl, H. T.; Doel, P.; Cunha, C. E.; Estrada, J.; Evrard, A. E.; Fausti Neto, A.; Finley, D. A.; Fosalba, P.; Frieman, J.; Gruen, D.; Honscheid, K.; James, D.; Kent, S.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Maia, M. A. G.; Makler, M.; Marshall, J.; Merritt, K.; Miquel, R.; Mohr, J.; Nord, B.; Ogando, R.; Plazas, A.; Romer, K.; Roodman, A.; Rykoff, E.; Sako, M.; Sanchez, E.; Santiago, B.; Schubnell, M.; Sevilla, I.; Smith, C.; Soares-Santos, M.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Tucker, D.; Walker, A.; Wechsler, R. H.

    2015-10-28

    We present the first results of a survey for high-redshift, z ≥ 6, quasars using izY multicolour photometric observations from the Dark Energy Survey (DES). Here we report the discovery and spectroscopic confirmation of the zAB, YAB = 20.2, 20.2 (M1450 = -26.5) quasar DES J0454-4448 with a redshift of z = 6.09±0.02 based on the onset of the Ly α forest and an H I near zone size of 4.1+1.1-1.2 proper Mpc. The quasar was selected as an i-band drop out with i-z = 2.46 and zAB < 21.5 from an area of ~300 deg2. It is the brightest of our 43 candidates and was identified for spectroscopic follow-up solely based on the DES i-z and z-Y colours. The quasar is detected by WISE and has W1AB = 19.68. The discovery of one spectroscopically confirmed quasar with 5.7 < z < 6.5 and zAB ≤ 20.2 is consistent with recent determinations of the luminosity function at z ~ 6. DES when completed will have imaged ~5000 deg2 to YAB = 23.0 (5σ point source) and we expect to discover 50–100 new quasars with z > 6 including 3–10 with z > 7 dramatically increasing the numbers of quasars currently known that are suitable for detailed studies.

  15. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex.

    PubMed

    Li, Qingyu; Zhang, Zhengyu; Li, Zengmin; Zhou, Mei; Liu, Bin; Pan, Le; Ma, Zhixing; Zheng, Yufang

    2013-01-01

    The radial migration of neuronal progenitor cells is critical for the development of cerebral cortex layers. They go through a critical step transforming from multipolar to bipolar before outward migration. A Disintegrin and Metalloprotease 17 (ADAM17) is a transmembrane protease which can process many substrates involved in cell-cell interaction, including Notch, ligands of EGFR, and some cell adhesion molecules. In this study, we used in utero electroporation to knock down or overexpress ADAM17 at embryonic day 14.5 (E14.5) in neuronal progenitor cells to examine the role of ADAM17 in cortical embryonic neurogenesis. Our results showed that the radial migration of ADAM17-knocked down cells were normal till E16.5 and reached the intermediate zone (IZ). Then most transfected cells stopped migration and stayed at the IZ to inner cortical plate (CP) layer at E18.5, and there was higher percentage of multipolar cells at IZ layer in the ADAM17-knocked down group compared to the cells in control group. Marker staining revealed that those ADAM17-knocked down cells differentiated normally from neural stem cells (NSCs) to neuronal intermediate progenitor cells (nIPCs) but did not differentiate into mature neurons. The migration and multipolar exit defects caused by ADAM17 knockdown could be partially rescued by over-expressing an shRNA resistant ADAM17, while overexpressing ADAM17 alone did not affect the radial migration. Taken together, our results showed for the first time that, ADAM17 is critical in regulating the multipolar-stage exit and radial migration of the nIPCs during telencephalon cortex development in mice.

  16. Distribution, diversity and abundance of bacterial laccase-like genes in different particle size fractions of sediments in a subtropical mangrove ecosystem.

    PubMed

    Luo, Ling; Zhou, Zhi-Chao; Gu, Ji-Dong

    2015-10-01

    This study investigated the diversity and abundance of bacterial lacasse-like genes in different particle size fractions, namely sand, silt, and clay of sediments in a subtropical mangrove ecosystem. Moreover, the effects of nutrient conditions on bacterial laccase-like communities as well as the correlation between nutrients and, both the abundance and diversity indices of laccase-like bacteria in particle size fractions were also studied. Compared to bulk sediments, Bacteroidetes, Caldithrix, Cyanobacteria and Chloroflexi were dominated in all 3 particle-size fractions of intertidal sediment (IZ), but Actinobacteria and Firmicutes were lost after the fractionation procedures used. The diversity index of IZ fractions decreased in the order of bulk > clay > silt > sand. In fractions of mangrove forest sediment (MG), Verrucomicrobia was found in silt, and both Actinobacteria and Bacteroidetes appeared in clay, but no new species were found in sand. The declining order of diversity index in MG fractions was clay > silt > sand > bulk. Furthermore, the abundance of lacasse-like bacteria varied with different particle-size fractions significantly (p < 0.05), and decreased in the order of sand > clay > silt in both IZ and MG fractions. Additionally, nutrient availability was found to significantly affect the diversity and community structure of laccase-like bacteria (p < 0.05), while the total organic carbon contents were positively related to the abundance of bacterial laccase-like genes in particle size fractions (p < 0.05). Therefore, this study further provides evidence that bacterial laccase plays a vital role in turnover of sediment organic matter and cycling of nutrients.

  17. Numerical simulation and sensitivity study of a severe hailstorm in northeast Spain

    NASA Astrophysics Data System (ADS)

    García-Ortega, E.; Fita, L.; Romero, R.; López, L.; Ramis, C.; Sánchez, J. L.

    2007-02-01

    During the afternoon of August 16th 2003 a severe hail event occurred in the town of Alcañiz in the Ebro Valley (Spain). This storm brought with it intense rain and hail precipitation that caused severe floods, damaged cars and street furniture. A diagnosis, using data from ECMWF, showed the presence of a mesolow at surface level centered over the Northeast of Spain, carrying winds from the Mediterranean Sea towards the Central Ebro Valley. At medium and high levels, a trough, whose axis extended over the Northwest of the Iberian Peninsula, moved eastwards preceded at 500 hPa by a thermal trough that caused increasing instability before the arrival of the geopotential trough. A numerical study of this event has been carried out using the MM5 model with a double aim. On the one hand, it attempts to check whether or not the simulation reproduces the storm in Alcañiz. On the other hand, it carries out a sensitivity experiment in order to evaluate the contribution of two specific factors: topography and solar radiation. Compared with radar data, the control simulation reproduces the region affected by the storm reasonably well. The suppression of topography and/or solar radiation substantially modifies the surface mesolow and the spatial distribution of the precipitation. Neither of these factors, considered independently, reproduces the precipitation caused by the storm in Alcañiz. However, the results illustrate the importance of the synergic effect of these two factors on the spatial localization of the storm and on the intensity of the precipitation registered.

  18. The features of structure and isomorphic substitutions in flux-synthesized V-containing beryls and V-containing beryllian indialite

    SciTech Connect

    Mikhailov, M. A.; Rozhdestvenskaya, I. V.; Bannova, I. I.

    2011-11-15

    An X-ray diffraction study of isostructural V-containing beryl (V-Iz) and V-containing beryllian indialite (V-BI) (the general formula M{sub 2}{sup VI}T2{sub 3}{sup IV}T1{sub 6}{sup IV}O{sub 18}){sup 1} synthesized in the Al{sub 2}Be{sub 3}Si{sub 6}O{sub 18}-Mg,Ca/F,Cl flux system with V{sub 2}O{sub 5} impurity has been performed. It is shown for V-Iz that the isomorphic replacement of some part of Al{sup 3+} in the octahedron with larger V{sup 3+} and Mg{sup 2+} cations and a small fraction of Be{sup 2+} ions with Al{sup 3+} in the interring tetrahedron T2, as well as the introduction of alkaline ions into R voids, leads to an increase in the average bonds lengths in the M position and increases the unit-cell parameter a at an insignificant increase in the parameter c. In V-Bi, the heterovalent replacement of some part of Mg{sup 2+} ions by V{sup 3+} ions, with complex isomorphism in all structural positions, is accompanied by the isovalent Mg{sup 2+} {yields} Fe{sup 2+} scheme. These substitutions cause some decrease in the parameter c of V-Bi with the preservation of its parameter a. It is found that T1 tetrahedra in V-BI are much closer to ideal than in V-Iz, T2 tetrahedra are distorted much more weakly, and M octahedra are distorted somewhat more strongly. However, the degree of distortion of the ring tetrahedron T1 in V-BI reaches 0.9 rel. %. This fact indicates that V-BI and Cr-BI have a similar disposition to congruent melting, which significantly inferior that of 'pure' species.

  19. Photometric brown-dwarf classification. II. A homogeneous sample of 1361 L and T dwarfs brighter than J = 17.5 with accurate spectral types

    NASA Astrophysics Data System (ADS)

    Skrzypek, N.; Warren, S. J.; Faherty, J. K.

    2016-05-01

    We present a homogeneous sample of 1361 L and T dwarfs brighter than J = 17.5 (of which 998 are new), from an effective area of 3070 deg2, classified by the photo-type method to an accuracy of one spectral sub-type using izYJHKW1W2 photometry from SDSS+UKIDSS+WISE. Other than a small bias in the early L types, the sample is shown to be effectively complete to the magnitude limit, for all spectral types L0 to T8. The nature of the bias is an incompleteness estimated at 3% because peculiar blue L dwarfs of type L4 and earlier are classified late M. There is a corresponding overcompleteness because peculiar red (likely young) late M dwarfs are classified early L. Contamination of the sample is confirmed to be small: so far spectroscopy has been obtained for 19 sources in the catalogue and all are confirmed to be ultracool dwarfs. We provide coordinates and izYJHKW1W2 photometry of all sources. We identify an apparent discontinuity, Δm ~ 0.4 mag, in the Y - K colour between spectral types L7 and L8. We present near-infrared spectra of nine sources identified by photo-type as peculiar, including a new low-gravity source ULAS J005505.68+013436.0, with spectroscopic classification L2γ. We provide revised izYJHKW1W2 template colours for late M dwarfs, types M7 to M9. The catalogue is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/589/A49

  20. Genetic Diversity of Brucella Reference and Non-reference Phages and Its Impact on Brucella-Typing

    PubMed Central

    Hammerl, Jens A.; Göllner, Cornelia; Jäckel, Claudia; Scholz, Holger C.; Nöckler, Karsten; Reetz, Jochen; Al Dahouk, Sascha; Hertwig, Stefan

    2017-01-01

    Virulent phages have been used for many years to type Brucella isolates, but until recently knowledge about the genetic makeup of these phages remains limited. In this work the host specificity and genomic sequences of the original set (deposited in 1960) of VLA Brucella reference phages Tb, Fi, Wb, Bk2, R/C, and Iz were analyzed and compared with hitherto described brucellaphages. VLA phages turned out to be different from homonymous phages in other laboratories. The host range of the phages was defined by performing plaque assays with a wide selection of Brucella strains. Propagation of the phages on different strains did not alter host specificity. Sequencing of the phages TbV, FiV, WbV, and R/CV revealed nucleotide variations when compared to same-named phages previously described by other laboratories. The phages Bk2V and IzV were sequenced for the first time. While Bk2V exhibited the same deletions as WbV, IzV possesses the largest genome of all Brucella reference phages. The duplication of a 301 bp sequence in this phage and the large deletion in Bk2V, WbV, and R/CV may be a result of recombination caused by repetitive sequences located in this DNA region. To identify new phages as potential candidates for lysotyping, the host range and Single Nucleotide Polymorphisms (SNPs) of 22 non-reference Brucella phages were determined. The phages showed lysis patterns different from those of the reference phages and thus represent novel valuable candidates in the typing set. PMID:28360895

  1. Transition from external imbricate zone to foreland thrust sheet in the Caledonides, N. Scandinavia

    NASA Astrophysics Data System (ADS)

    Rice, A. H. N.

    2010-05-01

    Thrust front geometries vary considerably between orogens, although erosion has usually removed external parts of the foreland thrust belt in older collision zones. This is the case in most of the Scandinavian Caledonides, where a well-defined basal decollement separates the nappe pile from the Autochthon. However, in both S and N Norway (E. Finnmark) thrust deformation dies out gradually towards the foreland. In Finnmark, the foreland thrust belt (Gaissa Thrust Belt) shows dominantly E-directed shortening. The internal part comprises the 50 km long (parallel to shortening) Munkavarri Imbricate Zone, with 50% shortening on 0.25-1.0 km spaced major imbricate thrusts. Minor thrusts/back-thrusts, are abundant near the basal decollement. Over ca. 12 km, major imbricate thrusts gradually cut up-section to lower stratigraphic levels, passing into tip-folds within the overlying Vuonjalrassa Thrust Sheet (20% shortening). The 10 km wide Låkkaskaidi Duplex (50% shortening), also underlies the Vuonjalrassa TS some 14 km to the foreland of the leading edge of the Munkavarri IZ. Stratigraphic overlap with the underlying Autochthon indicates that the Munkavarri IZ, Låkkaskaidi D and Vuonjalrassa TS were also transported en bloc towards the foreland by up to 25 km, along the Ruok'sadas Thrust. Below this, 20% shortening continues eastwards to the Hanadalen Thrust, in the footwall of which thrust ramps are no longer developed, although bedding-parallel slip continues further to the east. Sequentially, shortening in the Munkavarri IZ was likely of a continuously out-of-sequence nature, with all imbricate thrusts moving essentially together at the same time and older thrusts thus reaching higher stratigraphic levels as the basal decollement progressed towards the foreland. The decrease in shortening suggests a lower taper angle and/or faster thrust propagation. The cause of this is unknown, but much of the basal decollement under the Vuonjalrassa TS lies between pelitic rocks

  2. Computation of surface electrical potentials of plant cell membranes . Correspondence To published zeta potentials from diverse plant sources

    PubMed

    Kinraide; Yermiyahu; Rytwo

    1998-10-01

    A Gouy-Chapman-Stern model has been developed for the computation of surface electrical potential (psi0) of plant cell membranes in response to ionic solutes. The present model is a modification of an earlier version developed to compute the sorption of ions by wheat (Triticum aestivum L. cv Scout 66) root plasma membranes. A single set of model parameters generates values for psi0 that correlate highly with published zeta potentials of protoplasts and plasma membrane vesicles from diverse plant sources. The model assumes ion binding to a negatively charged site (R- = 0.3074 &mgr;mol m-2) and to a neutral site (P0 = 2.4 &mgr;mol m-2) according to the reactions R- + IZ &rlharr; RIZ-1 and P0 + IZ &rlharr; PIZ, where IZ represents an ion of charge Z. Binding constants for the negative site are 21, 500 M-1 for H+, 20,000 M-1 for Al3+, 2,200 M-1 for La3+, 30 M-1 for Ca2+ and Mg2+, and 1 M-1 for Na+ and K+. Binding constants for the neutral site are 1/180 the value for binding to the negative site. Ion activities at the membrane surface, computed on the basis of psi0, appear to determine many aspects of plant-mineral interactions, including mineral nutrition and the induction and alleviation of mineral toxicities, according to previous and ongoing studies. A computer program with instructions for the computation of psi0, ion binding, ion concentrations, and ion activities at membrane surfaces may be requested from the authors.

  3. In-vitro Callus Propagation and Secondary Metabolite Quantification in Sericostoma pauciflorum.

    PubMed

    C Jain, Satish; Pancholi, Boskey; Jain, Renuka

    2012-01-01

    Sericostoma pauciflorum Stocks ex Wight (Family Boraginaceae) used against cancer, diabetes and known to be health promoter. Callus cultures have been established from the stem explants on Murashige and Skoog (MS) medium supplemented with 1.5 mg/L concentration of different growth hormone viz. kinetin (Kn), indole 3-acetic acid (IAA) and indole 3-butyric acid (IBA). At 6 weeks of age, these calli were harvested, dried and extracted successively in pet, ether, methanol and water. Extracts were dried, weighed (%) and analyzed for their bioefficacies. Antimicrobial activities were determined using agar well diffusion and antioxidant potentials by DPPH and FRAP methods. Among all the test extracts, the extract of stem callus raised on IBA found to be more effective whereas it's pet. ether extract showed appreciable activity against both the test bacteria and fungi (S. aureus- IZ 14.00 ± 0.57 mm and T. rubrum- 16.33 ± 0.32 mm), followed by methanol extract (S. aureus- IZ 13.00 ± 0.57 mm, A. niger and P. chrysogenum- IZ 16.66 mm in both). In antioxidant potentials, all aqueous extracts were more active where IBA and Kn extracts demonstrated 0.06 mg/mL IC50 value (% inhibition 93.30 and 92.70 respectively at 0.8 mg/mL concentration) with 366 ± 6.69 and 343 ± 3.34 ascorbic acid equivalent antioxidant potentials at 1 mg/mL concentration. Furthermore, the chemical profile of test extracts was carried out. The bioactive secondary metabolites, β-sitosterol and caffeic acid was isolated from culture tissue of 6 weeks-old callus, and their identification and confirmation was carried out by color reaction, TLC behavior and IR spectrum techniques.

  4. A Dictionary/Directory System (DDS) for the SPLICE System.

    DTIC Science & Technology

    1984-06-01

    Strc e for Sa 11Cua q4S1 lectionatio DDSand m anlyi rlte wl r sntd ThA s prsnttc iz tiyuzE 2..4 AaLhird cs anerarchical Structurenfor iticula 3C1 Systef...IEII Data flanagement Architecture. ~45 E. IBIE- BA IION CF Cl liree asjects of integratE, LDS i. tLE cent rai2zc t distributed database envircnzent foi...the dictionary across the netwcrk can te sclved without much overhead. 0] Cf course the Ircblea cf distributed control in a netwcrk is nore complex

  5. N-Nitrosodimethylamine. Biodegradation

    DTIC Science & Technology

    1984-06-01

    ORGANIZATION NAME AND AODRESS 10. PROGRAM OLEMN T.-PROJECT’ TASK &!V WORK UNIT NUNSERSr-. US Arvy Natick R&D Center AH68 1)’IZ .02 W-61.: ATTN: STRNC-YEP...UNCLASSIF lED IS&. OECL ASSI FI C ATI ONDOWMGRADING SCHEDOULE Is. DISTRIBUTION STATEMENT (of ft Nt Report) Approved for public release, distribution ...unlimited. 17. DISTRIBUTION STATEMENT (o. the abstract entor.d In Block 20, It diffirent fom Reporf) • 1 -- IS. SUPPLEMENTARY NOTES It. KEY WORDS (Continue

  6. Issues Related to Recruitment of Enlisted Personnel for the Reserve Components. Volume 3. Methods Volume. Wave III.

    DTIC Science & Technology

    1981-03-01

    analyses are IzRs’id on samples of cal I records. Approxi- mrtely 50 perce,-nt of thc- NPS re-cords and 33 pe’ce,4nt of the PS re- cordis m~ 1’ sanpled...each block represented the nu’rer plus 74 backups. In the baseline study, a block conQsisted of 100 telephone numbers: one n -Iber pUs 90 backups...zip code structure of the design. 5. Every potential target name plus its associated backups constituted a single sampling block. The number of

  7. Antibody Responses in the Nonhuman Primate, Macaca Fascicularis, to Protein Toxins

    DTIC Science & Technology

    1990-05-01

    LITERATURE REVIEW A. General Animal models have been used in the past for investigation and manipulation of disease related parameters which cannot be... IgG4 A. The data reflect an expression of each subclass proportionally related to the total IgG response. to z z w z 01 U’) CD) C) (Ua 0s )S1A aGI 89...0, IgG2 +, IgG3 0, IgG4 A. The data reflect an expression of each subclass proportionally related to the total IgG response. 0O m z z, w U)Iz U) 2

  8. Ocean Magnetics: 1. Fundamental Survey and Estimates of Induction Phenomena

    DTIC Science & Technology

    1977-10-01

    detailed analy- sis for each of the many varieties of gyven flow u0 (Sec. 3). Var- ious approaches are appropriate for various flows ~ as indicated briefly...here. In shallow waters (KD < 1, W X Krg-D), bottom effects become important. The flow amplitude Zi0 hap, little depth variation, and the OM field...at depths IzI : 1/K r T2 /4, where, however, exponential decrease also becomes dominant. More I detailed curves will be found, for example, in Ref. 4

  9. Reduced PM2.5 Emissions for Military Gas Turbine Engines using Fuel Additives

    DTIC Science & Technology

    2006-08-12

    Diagram of GC/MS Subsystem of PMCMS. 32 Figure 2.1.2-10. Particle Size Distribution for Ethylene Fuel vs Equivalence Ratio. 33 Figure 2.1.2-11...Particle Size Distribution for WSR on Ethylene Fuel vs Equivalence Ratio. 0 0.2 0.4 0.6 0.8 1 1.2 0 5 10 15 20 25 30 35 Size (nm) N or m al iz ed...information on the computed solutions is provided in Figure 3.1.3-12 in which the size distribution of soot particles is provided for a range of equivalence

  10. The Phantom Fleet--Foreign Flags on U.S. Ships.

    DTIC Science & Technology

    1982-06-01

    Co)I=4 61- 0.- 26 c1. ~ ~ - N *1-4 C, 41 - - - - - CdCD C3-a -AI 03$ Cie L_6_._Col_ _ L"~ CC) = V Iz C0 c 2r-U. U, Lo - - - - - - - - . cc x owL .- mC... Madagascar (port negotiations underway), Angola and Libya. All have leftist governments providing potential inroads for the Soviet Union which...the Egyptian port of Ain el-Sukhna on the Red Sea to the terminal of Sidi Kreir on Egypt’s Mediter- ranean coast was opened. SUMED’s current capacity

  11. Prognostic Significance of Telomere Attrition in Ductal Carcinoma in situ of the Breast

    DTIC Science & Technology

    2009-02-01

    Burstein, HJ, Polyak , K, Wong, JS, Lester, SC and Kaelin, CM. Ductal Carcinoma in Situ of the Breast. N Engl J Med 350:1430-41, 2004. 4. Page DL, Dupont...nodeT a b le 1 . C h a ra ct er is ti cs o f tu m o r ti ss u es S et a N S iz e (m m ) N o d e in v o lv em en t T N M st a g e N u m b er o f d ea th s

  12. Prognostic Significance of Telomere Attrition in Ductal Carcinoma in Situ of the Breast

    DTIC Science & Technology

    2008-02-01

    Cancer Society, Atlanta, GA, 2004. 3. Burstein, HJ, Polyak , K, Wong, JS, Lester, SC and Kaelin, CM. Ductal Carcinoma in Situ of the Breast. N Engl J...o f tu m o r ti ss u es S et a N S iz e (m m ) N o d e in v o lv em en t T N M st a g e N u m b er o f d ea th s a t 5 -y ea rs o f fo ll o w u p M

  13. Prognostic Significance of Telomere Attrition in Ductal Carcinoma in Situ of the Breast

    DTIC Science & Technology

    2007-02-01

    Polyak , K, Wong, JS, Lester, SC and Kaelin, CM. Ductal Carcinoma in Situ of the Breast. N Engl J Med 350:1430-41, 2004. 4. Page DL, Dupont WD...S et a N S iz e (m m ) N o d e in v o lv em en t T N M st a g e N u m b er o f d ea th s a t 5 -y ea rs o f fo ll o w u p M ed ia n M ea n R a n g e

  14. Imaging of Ocean Waves by SAR

    DTIC Science & Technology

    1988-01-01

    SAR o Contract N00014-87-C-0687N TDTIC R.L. Schult iZ L E C T E F.S. Henyey -JAN 2 4 1989 J.A. Wright Center for Studies of Nonlinear Dynamics La...Waves by SAR R.L. Schult F.S. Henyey J.A. Wright Center for Studies of Nonlinear Dynamics La Jolla Institute 7855 Fay Avenue, Suite 320 La Jolla...TOWARD data. 467.abstract 7-13-󈨜 Imaging of Ocean Waves by SAR 1. Introduction Synthetic Aperture Radar images of long-wavelength features on the

  15. Report to the Office of Naval Research for Contract N00014-89-J-1108 (Texas A&M University)

    DTIC Science & Technology

    1989-12-31

    written in the equivalent form, (c.f. [1]). +(t) = {r’ I +H(t, )O(r) dr (2.6) where H is a C’ function. This equation is of second kind Volterra type and...can be uniquely solved for the function 4. Thus = A-’O = (I+ I) (2.7) where IZ is the resolvent operator corresponding to the Volterra integral...span of the species. The first mathematical model along these lines was proposed by Lotka . In this treatment one assumes as known, a birth function 3

  16. Sequential Medical Trials Involving Paired Data.

    DTIC Science & Technology

    1979-05-22

    2.3.2 ) and (2.3.3). If at any time ~~~ = 1 — $ ( IZ I ) stop taking observations and for the remaining N-2t units of time use * the treatment in...stopping times are restricted to those for which t takes on the values t = (a~~ + no 2 ) ~~~~~ + Na 2/2) . When N is large the successive differences...John Petkau Department of Mathematics University of British Columbia SUMMARY A continuous time version of Anscombe ’ s formulation of the problem of

  17. Experimental Studies of Graphite-Epoxy and Boron-Epoxy Angle Ply Laminates in Shear,

    DTIC Science & Technology

    1977-09-01

    SPECIMENS tr15 0 BIEP I.- TEST 63 RUN 6SHERjR STRtiN MNII*N") ~iTEST 535 RUN 7 STEST 536 RUIN a uu .OU3 .00’i � gull 0 .00 W- -,-mou .0 ! .02 01...0.9 SERSTRAIN (No) FIG. 16A SHEAR RESPONSE OF PLANAR SPECIMENS 1300 BIEP X03 I-z I7 .rr~~5Qr~csc o~i~70 SHE~f SIRAIN (N/tN TEST 18:SHR 53S5NS OUN 1UUR

  18. Predictors Related to Premature Attrition of Navy Recruits

    DTIC Science & Technology

    1973-08-01

    s differentiating men on the basis of subsequent effectiveness . The costs of ’Iz 4 7 - IHoiberg, et al B premature attrition are extremely high; the...8217PREDICTORS RELATED TO PREMATURE ATTRITION OF NAVY RECRUITS C. J. HYSHAM ’- N. H. BERRY r ~ REPORT NO. 73-48 NAVAL HELTH IESARCH, CENTER, SAW ltdoý...8217%O yALORNIAo 92152, NAVAL MEWICALAREEARCH ANO DEVELPPMENT COMMAND *j&8~~D~ARLN -~10 db13Wll.mb E PREDICTORS RELATED TO PREMATURE ATTRITION OF NAVY

  19. Zionism and Southern Lebanon: A Historical Perspective on Six Decades of Controversy

    DTIC Science & Technology

    1979-06-01

    191- I 12 -1:cnden: The Athione Press , 1969), p.36 Obee Zeine, The Strule for Aab indeRnenence, Plate o, which is a reproduction of the attached to...parties to ex-loit those resources and t e pressed colateral benefits to Lebanon res ltin- from Zionist exploitation, originated with the above passage... Press , iZ7E). The r::action of Great Britain to the Zionist 22?onie claim was predictably f’avorable. What4, aftralcod her own pr-ote&.ctorate at the

  20. Electroactive, Near Infrared Absorbing Nickel Bis(dithiolene) Complex Polycarbonates and Polyurethanes

    DTIC Science & Technology

    1991-04-12

    Waters 840 GPC system with UV (300 nm) and refractive index detector accessories. TGA and DSC were carried out on a DuPont 9900 Thermal Analysis 16...REPOR-, 7t DECLASSIF IA O o.rRADirG SCHEDU 4PER;ORMING ORCANIZATION REPORT tNjv BER S, T,7 EOflRirZ p(- At, iz AT lor. -E POR7T N~uvbE R S, 6a NA ME OF...films can be cast from solution. Gel permeation chromatographic analysis on these polymers indicates hydrodynamic volumes comparable to polystyrene

  1. Characterization of Ionosphere Waveguide Propagation by Monitoring HAARP HF Transmissions in Antarctica

    DTIC Science & Technology

    2015-04-17

    hhh hhhh hh (7а)  .)cos(cos)sincoscos( cos)coscossin( cos 1sin 0 2)(22 0 2)( 00 )( 00 )()( 00 )( 00)(22 0 2 0 )( 2,1         s x i...z i xz si z i xxs xz s hhhh hhh hh   7b) Here the top sign stands for )(1 s , while the lower sign stands for )(2 s . It is also taken into

  2. Basic Processes of Plasma Propulsion.

    DTIC Science & Technology

    1987-08-01

    s T*S IFI /G i’ u A "m = - ILI l ~2 U0k.. ’~la BASIC PROCESSES OF PLASMA PROPULSION Herbert 0. Schrade Institut fir Raumfahrtsysteme Universitat...discharge channel with respect to a small disturbance. IZ4 q, , L No cl W) 03Cii >i 04 -9- Depending on the amouunt of e given in eqs. (la) and (Ib) and...available at the University of Stuttgart about a year ago. H. 0. Schrade, M. Auweter-Kurtz and H. L . Kurtz, "Basic Processes of Plasma Propulsion

  3. An Analysis of the Impact of Reliability and Maintainability on Maintenance Manpower Requirements and Mission Effectiveness for the F-16 Implementation by the Turkish Air Force

    DTIC Science & Technology

    1986-12-01

    the procurement of the F-16 started in 1984 with the signature of a Letter of 1N Acceptance (LOA) between Turkey and the United States . Under this...ORGANIZATION j(if appicable.) IZ7 ADDRESS (City, State . and ZIP Cod.) 10. SOURCE OF FUNDING NUMBERS PROGRAM IPROJECT ITASK IWORK UNIT ELEMENT NO. INO. INO...EFFECTIVENESS FOR THE F-16 IMPLEMENTATION BY THE TURKISH AIR FORCE THESIS Muammer Akpinar First Lieutenant, TUAF AFIT/GOR/OS/86D- 1 Approved for public

  4. Change in Deep Convective Ice Water Content and Rainrate as Cbserved from AURA MLS, CloudSat, Aqua MODIS, and ISCCP Datasets.

    NASA Astrophysics Data System (ADS)

    Chakraborty, S.; Fu, R.

    2014-12-01

    The influence of aerosols on ice water content (IWC) and rainrate has been suggested by some numerical simulations and observational studies. This is often complicated by a lack of contextual information regarding the dynamic structure and life cycle of the cloud systems. We investigate IWC and rainrate from deep convections (DC) using datasets from AURA Microwave Limb Sounder, CloudSat, Aqua Moderate Resolution Imaging Spectroradiometer, and International Satellite Cloud Climatology Project over the Congo, the Amazon, and South Asia during three different stages of lifecycle. We use measurements from AURA MLS to investigate the change in water content associated with the smaller sized ice crystals at anvil level and CloudSat to derive the relation between the amounts of larger sized ice crystals and rainrate with ambient aerosol loadings. We integrate reflectivity above freezing level (IZ) to calculate the amount of ice and differentiate reflectivity (DZ) with respect to altitude below the freeing level to estimate the attenuated rainfall under the cloud. Our analysis using the reflectivity data shows that IZ and DZ don't change with aerosols loadings during the growing stage. However, IZ increases and DZ decreases, suggesting a delayed precipitation and increase of ice formation, during the matured stage. During the decaying stage, DZ increases, leading to a loss in larger ice particles or as shown by a decrease of the IZ above freezing level. IWC within the anvils of the DCs during their growing stage shows no significant relations with the ambient aerosol concentration over the Congo and South Asia. However, anvil IWC decreases during the matured stage over the South Asia and increase over the Congo as aerosol optical depth surrounding the DCs increases. Aerosol's concentration plays an important role during the decaying stage and is significantly and positively correlated with the IWC of the anvils, suggesting an increase of smaller ice particles in convective

  5. Comments on IDA Paper P-2863, A Comparison Air Force Data Systems

    DTIC Science & Technology

    1993-08-01

    as IDA moves towards finalizing their report. I (• JL qJO M . GILLIG 4’ Air Force Program £Excutive Officer 2 Atch *for Combat Support Systems 1... M o- C IL m - (Au A -K M1I f- 11 4n I- 4D ’A 4C c 4C 4v us 4ý 4L K 4A > 4 4 0 1: 8inll- c -4 𔃽 C9 .5- bo(a4 Iz W- U -.1 U.1 b- FA.I- U)0 on- -a . - j ...Litton Computer Services ................................................................................. IV- 1 j A. Forwarding Letter

  6. THz semiconductor-based front-end receiver technology for space applications

    NASA Technical Reports Server (NTRS)

    Mehdi, Imran; Siegel, Peter

    2004-01-01

    Advances in the design and fabrication of very low capacitance planar Schottky diodes and millimeter-wave power amplifiers, more accurate device and circuit models for commercial 3-D electromagnetic simulators, and the availability of both MEMS and high precision metal machining, have enabled RF engineers to extend traditional waveguide-based sensor and source technologies well into the TI-Iz frequency regime. This short paper will highlight recent progress in realizing THz space-qualified receiver front-ends based on room temperature semiconductor devices.

  7. A Historical Overview for the MX Base Expansion, Clovis, New Mexico.

    DTIC Science & Technology

    1981-07-01

    pointing out directions for further study which I believe are of interest . Accession F~r N TI *JAS Dis alt, L&Iz METHODOLOGY This study has two major...in small karst sink features and the filled-in swales which now mark the course of certain extinct Pleistocene streams or rivers. In the case of the...necessary to define in general terms who these groups were and what the nature of their cultural adaptations to the area was. * At the time of earliest

  8. Theoretical and Experimental Study of Thermoacoustic Engines

    DTIC Science & Technology

    1991-12-31

    medium as a collection of circular capillary tubes.t The generalization to capillary tubes of arbitrary geometry has recently been explored. 12 The...dxdy (SY Her Am is the cross-sectional ae of the resonance tube at point z, A is.the cross-sectional area of a single pore, 12 is porosity, K 8 a and...The pressure translation theorem is Pj(z-d) =Pj(z) (os(kd) - zin sin(kd)) (19) Heat and work flow are A= 5 To Iiz12( 2 1 + Npr IZ(z) 12 [Re (Z(z)* {FQ

  9. Expressive Threat Detection Validation Framework

    DTIC Science & Technology

    2006-06-01

    iv ity N oi se , C...8 Dataset Name G ro up C on ne ct iv ity N oi se , C lu tte r D at as et S iz e Po pu la tio n Si ze Pa tte rn C om pl ex ity O bs er...Attack agency Interaction type \\ Source Fo cu se d su rv ei lla nc e Br oa d su rv ei lla nc e C on ne ct iv ity p ro vi de r O pe n so ur

  10. 16-Inch Gun-Launched Anti-Satellite Weapon

    DTIC Science & Technology

    1982-06-01

    public release, distribution unlimited 16-Inch Gun-Launched Anti-Satellite Weapon by Joseph John Natale Lieutenant, United States Navy B.A., University...w N L- UN H LLWIrNO0W CCT’. W W W ww WuflswrSx’x 0 ma. 63 I I I IZ I - I M w I I I lIL, I-.. CI =1 w I 1 1--* CL M~ WW OD 0 CL CL CL ODV CL a It...Dr. L. V. Schmidt Assistant Secretary of the Navy Assistant for Engineering Technology (R. E. and S) Pentagon SE731 Washington, D.C. 20350 6

  11. Weather Support as a Ground Combat Multiplier

    DTIC Science & Technology

    1980-05-01

    ornnrnd/or 15 ......................... ae .-~nIn -ro or via *.: cee cm- a r : t o C’-aux 37 rma Ie et s or j ven in Dorntu --ituations. ~ Cli--atic 3tu...ort to echealons bo.;divi.sion th-at do no-: have ther c;nS’,70 iz a rovided tho~hG2/62 channeis via telenholn2, radio, :on-_d/or tae-ty-ai’ 2 The...arld in the future,vwith the flood of additional battlefield infor- mation rrovided by automation and so-hizticated but hiLzhly- wes her- sensitiva

  12. Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways.

    PubMed

    Lapi, A; Pratviel, G; Meunier, B

    2001-01-01

    In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.

  13. ACOSS Twelve (Active Control of Space Structures)

    DTIC Science & Technology

    1982-12-01

    Analysis 10 1-VII Controller Robustness Investigation 12 I 1-VIII Robustness Definitions 12 1-lX Loop Transfer Recover on 2-Mode Example 15 I- X ...Results 2-V Correlation of Test and Analysis 67 2-VI Model Sensitivity 67 x 6. 1.0 ANALYTICAL RESEARCH FOR CONTROL METHODOLOGY DEVELOPMENT (TASK 1.0...include more modes than previously considered. The three I ’kA",PSD location Ix, V. 1I( ?.Is, 1 12 IV, Z) x * V. i Z is. 1 9. 9 (Y. 21 a I?. Iz 1

  14. Synchronization of chemical noise-sustained structures in asymmetrically coupled differential-flow reactors.

    PubMed

    Izús, Gonzalo G; Sánchez, Alejandro D

    2013-12-01

    The differential-flow-induced chemical instability is investigated in the context of two coupled reactors with cubic autocatalytic kinetics (the Gray-Scott model). Previous results for master-slave arrangement [Izús, Deza, and Sánchez, J. Chem. Phys. 132, 234112 (2010)] are extended in this study to include bidirectional coupling between reactions. Numerical simulations in the convectively unstable regime show that synchronized noise-sustained structures are developed in both reactors due to the selective amplification of noise. A theoretical analysis shows that the nature of the synchronization and the stability of the synchronized manifold are related with the properties of the critical modes.

  15. Response of a Plain and Filled Elastomer (Solithane 113) to High Strain-Rate Compression, Shear, and Tension Loading.

    DTIC Science & Technology

    1981-01-01

    one study, 1 5 tensile fracture due to stress wave interaction was examined in a polycarbonate. Penny - shaped tensile cracks were observed in the...reasonable. In our calculations, we have approximated the response of the glass beads using Keough’s data on soda lime glass4 2 3(Po - 2.49 g/cm ) to...follows: 1 8 CLH a [(KH + 4/3 GH)/p]1 /2 (4.4) CSH = (GH/P)1 /2 (4.5) 52 <IZ 4I - 1 12 Soda Lime Glass Unfilled SolithaneCalculated 10 Filled

  16. Closed-loop conductance scanning tunneling spectroscopy: demonstrating the equivalence to the open-loop alternative.

    PubMed

    Hellenthal, Chris; Sotthewes, Kai; Siekman, Martin H; Kooij, E Stefan; Zandvliet, Harold J W

    2015-01-01

    We demonstrate the validity of using closed-loop z(V) conductance scanning tunneling spectroscopy (STS) measurements for the determination of the effective tunneling barrier by comparing them to more conventional open-loop I(z) measurements. Through the development of a numerical model, the individual contributions to the effective tunneling barrier present in these experiments, such as the work function and the presence of an image charge, are determined quantitatively. This opens up the possibility of determining tunneling barriers of both vacuum and molecular systems in an alternative and more detailed manner.

  17. The United States, Saudi Arabia, and Arms: Prospects for Future Instability in the Alliance

    DTIC Science & Technology

    1993-12-01

    KShaqraI . Q Medinar #. UI U.A.E. /SS~AUDI ARABIA " Jeda Makkah i /’Layla I EASTERN_ TiMAKH RIYADH I PROVINCE -AI 0 OMAN BAHA , I - SUDANRed Seam ASIR...FORM 1473,84 MAR 83 APR edition may be used until exhausted security classification of this page All other editions are obsolete i UNCLASSIFIED Approved...instability in the region. D~ . . . .c ;aos ,iz i Din TABLE OF CONTENTS I . INTRODUCTION AND THE FORMATION OF THE HOUSE OF SAUD 1 A. BIRTH OF A NATION

  18. Low-Cost Deposition Methods for Transparent Thin-Film Transistors

    DTIC Science & Technology

    2003-09-26

    h ot p la te an n ea li n g. S E M X R D S ol ve n t P re -B ak e F in al B ak e X R D G ra in F ig . F ig . B ak e S iz e (n m ) 4. 5 4. 9 14 0◦ C...N. Basu, A. K. Batabyal , and A. K. Barua, “Properties of tin doped indium oxide thin films prepared by magnetron sputtering,” J. Appl. Phys., vol. 54

  19. A Geometric Optics Model for Calculating the Field Strength of Electromagnetic Waves in the Presence of a Tropospheric Duct.

    DTIC Science & Technology

    1977-12-01

    any other person or corporation , or conveying any rights or permission to manufacture use, or sell any patented invention that may in any way be...which has been adapted from a ray tracing program developed by the MITRE Corporation . 9 - At regular intervals along the earth’s surface, which are...XMAX,YMAXNREPFNRAY,NPRO,!4PLOT,NGRAD I. <REF,KGRAD,KP.OT DIMENSION AHO(81 ,TT’. (8),XTL(8) , YTL (83 ,TLE(83 ,ZT. (1) DATA Y~iN,YsIz,SIZE/0.0,5.C0.1505

  20. The Propagation of Slip Across Alpha/Beta Interfaces in Titanium Alloys.

    DTIC Science & Technology

    1981-12-01

    method. The first stage conusists. of ’jetting’ each surface of the disc (which is Munted on a stainless steel gauze) with a stream of electrolyte. rf the...temperature 30 mL sulphuric acid and ,.70 volts. 300 ml methanol ’Final polishing’ solution at <c-5O 0 C 15 ml sulphuric acid and "IZ volts. These...proposed to describe the crystallography of the austenite to martensite transformation in steels . Case Mb A twinning shear on every alternate (!2

  1. Letters

    NASA Astrophysics Data System (ADS)

    1999-11-01

    Survey of Binary Azeotropes by Paul C. Yates Re: article by R. J. Glinski, C. W. Smith, and J. B. Cooke Cheating Probabilities? Probably Not by David J. Miller Re: a criticism by C. Jonah and a note by G. T. Rizzuto and F. Walters trans-Cyclohexane-1,2-diamine by Richard S. Treptow Re: article by P. J. Walsh, D. K. Smith, and C. Castello Micropreparation of [RuH2PPh3)4] by Francisco J. Arnáiz Re: article by D. E. Linn, Jr. The author replies D. E. Linn's response follows

  2. Numerical Analysis of Double Antennas. Volume 2

    DTIC Science & Technology

    1988-12-01

    oRE h4I-B&~IM DOUBLE CELTA / FAIP.GNID. Z, 25 myZ _ELA / _AZJN. 5 uwZ AZIMUTHPA-TTERN /ELEVATION ANGLE =2U AIiuT. PATTRN LE vA1ION itN4GLEJ£ 300 .10...perfect ground * and fair ground at 7 I\\1I-z 241I ESI322A RO~eAD OULE ELA I~EV. ND /7 M-HZ ESI 32A2 A OAUD DOUBLE CELTA I VERU. GIL yj-2 ES 22AZIMUTH

  3. Spectral-Domain Analysis of Finite Frequency Selective Surfaces

    DTIC Science & Technology

    1989-08-01

    field will be a discrete spectrum of plane waves of the form, 3 ES(z > zt) = ( epq + eOO0p8Oq)e j (aPtx +fipqy)- oqZ, (5.1) 3 p,q = _,, where (5mn is...with the vector constants epq is due to the induced current on the printed surface radiating in the I presence of the dielect ic medium; and (2) the...are omitted here.Iz Figure 5.1. Arbitrary periodic surface surrounded by an N-layer dielectric medium. I To find the constants epq , the strategy is to

  4. Coherent Control of Diamond Defects for Quantum Information Science and Quantum Sensing

    DTIC Science & Technology

    2014-04-18

    detection of individual spins: one relies on electrical and the other on optical measurements. Phosphorus doped silicon (Si:P) is one particularly...34 12 "N or m al iz ed "d iff er en ce "" of "c ou nt "ra te " 0" 1" t"(sec)" Figure 2.4: | Nuclear depolarization rate. Nuclear spin orientation...ohmic heating of lithographically fabricated nano structures has been employed to induce the growth of ZnO nano-wires with spatial resolution below 100

  5. An Atlas of Basic Transmission Loss for 0.125 to 15.5 GHz

    DTIC Science & Technology

    1980-08-01

    8217 1. INTRODUCTION Increasing air traffic density and fast, high-flying jets have made reliable navigation and communication systems for aircraft more...ground, isotropic ant.annas, - . O) I0C 12~00 14Z00 I MLCC 1?1500 a- kC’~ .rn ~ vau. s.~ ic~a~ transmission loss versus distance, F’ 100 MhIz, 11 15 00 M... reliability at a higher cost where cost may include a requirement for more frequencies j 110 110 to provide a particular service. Except when Q=0.5, the

  6. Evaluating the O*NET Occupational Analysis System for Army Competency Development: Supplemental Appendices

    DTIC Science & Technology

    2008-07-01

    i 00 » i i a a « >>Z III £ , iZ h. Crt TJ bpe e d o f Li m b M ov e m en t S ta tic St re n gt h E xp io si ve St...CO -O ( bpe e d o t Li m b M ov e m en t S ta tic St re n gt h E xp lo si ve St re n gt h D yn a m ic St re n gt h Tr un k

  7. Cost Estimates for Desert Shield/Desert Storm a Budgetary Analysis

    DTIC Science & Technology

    1991-12-01

    AD-A244 67511111111 I Ill Illll 11111111l11 I ,11 l NAVAL POSTGRADUATE SCHOOL Monterey, California Iz DTIC ?PXLECT R 9 JAN 2 1992 u THESIS Cost...Professor William R . Gates Professor Katsuaki L. Terasawa Second Reader: Professor Richard B. Doyle Approved for public release: distribution is unlimited. b...NAME OF RESPONSIBLE INDIVIDUAL 22b TELEPHONE (Include Area code) 22c OFFICE SYMBOL Professor William R . Gates (408) 646-2754 Code AS/GT DD FORM 1473.84

  8. An Efficient Exact Algorithm for the ’Least Squares Image Registration Problem

    DTIC Science & Technology

    1989-05-01

    Zika -i TECHNICAL REPORT SOL ,J-5 May 1989 DTI.C , SELECTE ’" JUN 0 619891 F• • Department of Operations Research Stanford University Stanford, CA...the two-dimensional image registration problem. If X is a two-dimensional vector , then let x = zI + iz2 = [1xI4,9,. be the corresponding complex number...product. Therefore (x, y) = x c y for complex numbers, (z, y) = zry for real k-dimensional vectors , and if A and B are real n x k matrices, then let

  9. The Effects of Net-Shape Machining on the Performance of Al 2024-T3 Subjected to Axial Tension-Tension Fatigue Loads

    DTIC Science & Technology

    2010-08-01

    Shigley and Mitchell, 1983)............2 Figure 2. Sawtooth and sinusoidal profile of a machined surface...terms of the endurance limit or magnitude of applied cyclic stress below which the component exhibits infinite life. Shigley and Mischke (1989) have...roughness ( Shigley and Mitchell, 1983). 3  L a dxz L R 0 1 (2) minmax zzRy  (3)          5 1 min 5 1 max )()( 5 1 j j i iz zzR . (4

  10. Y-TZP ceramic processing from coprecipitated powders: a comparative study with three commercial dental ceramics.

    PubMed

    Lazar, Dolores R R; Bottino, Marco C; Ozcan, Mutlu; Valandro, Luiz Felipe; Amaral, Regina; Ussui, Valter; Bressiani, Ana H A

    2008-12-01

    (1) To synthesize 3mol% yttria-stabilized zirconia (3Y-TZP) powders via coprecipitation route, (2) to obtain zirconia ceramic specimens, analyze surface characteristics, and mechanical properties, and (3) to compare the processed material with three reinforced dental ceramics. A coprecipitation route was used to synthesize a 3mol% yttria-stabilized zirconia ceramic processed by uniaxial compaction and pressureless sintering. Commercially available alumina or alumina/zirconia ceramics, namely Procera AllCeram (PA), In-Ceram Zirconia Block (CAZ) and In-Ceram Zirconia (IZ) were chosen for comparison. All specimens (6mmx5mmx5mm) were polished and ultrasonically cleaned. Qualitative phase analysis was performed by XRD and apparent densities were measured on the basis of Archimedes principle. Ceramics were also characterized using SEM, TEM and EDS. The hardness measurements were made employing Vickers hardness test. Fracture toughness (K(IC)) was calculated. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test (alpha=0.05). ANOVA revealed that the Vickers hardness (p<0.0001) and fracture toughness (p<0.0001) were affected by the ceramic materials composition. It was confirmed that the PA ceramic was constituted of a rhombohedral alumina matrix, so-called alpha-alumina. Both CAZ and IZ ceramics presented tetragonal zirconia and alpha-alumina mixture of phases. The SEM/EDS analysis confirmed the presence of aluminum in PA ceramic. In the IZ and CAZ ceramics aluminum, zirconium and cerium in grains involved by a second phase containing aluminum, silicon and lanthanum were identified. PA showed significantly higher mean Vickers hardness values (H(V)) (18.4+/-0.5GPa) compared to vitreous CAZ (10.3+/-0.2GPa) and IZ (10.6+/-0.4GPa) ceramics. Experimental Y-TZP showed significantly lower results than that of the other monophased ceramic (PA) (p<0.05) but it showed significantly higher fracture toughness (6.0+/-0.2MPam(1/2)) values when compared to the

  11. Artificial Intelligence Indexing: Creating Knowledge Bases of Index Terms Ordered by Semantic Relations.

    DTIC Science & Technology

    1985-12-01

    8217 IZ% approach constructs relational thesauri ho improve retrieval performance in response to user queries. Current on-line information retrieval...34Relational thesauri in information retrieval." J a of the AemeiQaD BQQiey fQ1 in f! Qion BQiepge. Vol. 36, No. 1, pp. 15-27, 1985. r* geaQh...TEXT ANALYSIS Most language understanding efforts use a large dictionary or lexicon (on the order of 30,000 words or more). Yet these systems often

  12. Visualization of Surfaces in Four-Dimensional Space

    DTIC Science & Technology

    1990-03-01

    constraints for offset surfaces ....... and Voronoi surfaces [3, 8, 15]. For inspection and understanding of the properties related to geometry, pictures are...in iZ a and )Z2 and the pitch of the front clipping plane. All these quantities are with respect to the (x6, y6, z6, w6)-coordinate system. 4...Figure 8 also shows how, by using the tilted front clipping plane, some hidden details can be revealed. See also [11] for a visualization of 4D rotation

  13. Dynamic Analysis of a Combat Aircraft with Control Surface Failure

    DTIC Science & Technology

    1990-11-01

    a ) dZ = m ( w + V0 p - U0 q + g (cos9 0 sin$0 ) * + g (sin90 costo ) e ) (D-4) dL = P IX - f I XZ I dM = 4 Iy dN = t IZ - P IXZ D-3 I and the...sinto ) 0 - q (sineo costo ) e p=dL IZI) + dN xzZ 1 dM Z I X) (D-7) Iy t = dL IXZ + dI = p +q ( ane 0 sinf 0 ) + r (tane O cos 0 ) I = q cost O - r sine O

  14. Elasto-Plastic Behavior of Plates and Shells

    DTIC Science & Technology

    1976-03-31

    middle surface 3 z ). = e.. + ki z (iZ i " ii (1) ; and in the expressions for the membrane forces and the bending moments (stress resultants) h /2h/ 2 N...cr. dz M a .i z dz (2) -h/2 -h/2 It becomes evident from the above equations that, within the accepted approximation, there is no distinction...increments of strains .. ( z ) are determined with Eqs. (1); then, from appropriate 4j Aconstitutive equations of the material, the increments of

  15. Nonlinear Microwave Properties of Atomic Layer Controlled HTS Multilayers

    DTIC Science & Technology

    2008-04-14

    nm YBCO 160 nm YBCO 160 nm YBCO -160 -130 - 100 -70 -40 -10 0 10 20 30 Circulating power (dBm) N or m al iz ed IM D p ow er (d B m ) Single layer...film with each YBCO layer 160- nm thick interspersed with CeO2 buffer layers 40- nm thick, giving an aggregate thickness of 640 nm of YBCO . The...flux penetration and flux motion are sources of loss. Thickness dependence of IMD of YBCO

  16. 9433 Design Pointing Anomaly. Volume II. Appendices

    DTIC Science & Technology

    1976-01-30

    CALIFORNIA 90278 This final report was submitted by TRW Defense and Space t ) Systems Group, One Space Park, Redondo Beach, CA 90278, under Contract F04701-75...NTIS G:A&I FOR THE COMMANDER T J E . FREYTAG, C.. ’- em Program Dir tot, DSCS * puty for Space Comm Systems UNCLASSIFIED SICURI.YY CL ASSIFVICATION Of...90278__ ___________ 11I. CONTROLLING OFFICE NAME AND AORE’sS r a iz t jSpace and Missile Systems Ognzton 3 Jan~A&Fy-476 Air Force Systems CommandI Loas

  17. Embankment Criteria and Performance Report, Red River Watershed, Dierks Lake, Saline River, Arkansas

    DTIC Science & Technology

    1987-10-01

    120IZ, 110~ 2 1 ’/~L Area 9BArow MaterWa f _______________________ TRIAXIAL. COMPRESSION TEST REPORT tNs PORN I WAYe 2089 PRESt V IIO5NS AA1 OUSOLIETE...SOOSIAT ~O RC L~ GAI 0 ___ - ~/03-74 01-1.3 0113,0 1-73 --1433 65 l~zb-1* (I72A / o,-,,oso 01,7,o,-1., ,., al61- 1060 O|’ 7 1 L -90 .49 -- 󈧅-68 Z---r

  18. Dose equations for shift-variant CT acquisition modes using variable pitch, tube current, and aperture, and the meaning of their associated CTDI{sub vol}

    SciTech Connect

    Dixon, Robert L.; Boone, John M.; Kraft, Robert A.

    2014-11-01

    Purpose: With the increasing clinical use of shift-variant CT protocols involving tube current modulation (TCM), variable pitch or pitch modulation (PM), and variable aperture a(t), the interpretation of the scanner-reported CTDI{sub vol} is called into question. This was addressed for TCM in their previous paper published by Dixon and Boone [Med. Phys. 40, 111920 (14pp.) (2013)] and is extended to PM and concurrent TCM/PM as well as variable aperture in this work. Methods: Rigorous convolution equations are derived to describe the accumulated dose distributions for TCM, PM, and concurrent TCM/PM. A comparison with scanner-reported CTDI{sub vol} formulae clearly identifies the source of their differences with the traditional CTDI{sub vol}. Dose distribution simulations using the convolution are provided for a variety of TCM and PM scenarios including a helical shuttle used for perfusion studies (as well as constant mA)—all having the same scanner-reported CTDI{sub vol}. These new convolution simulations for TCM are validated by comparison with their previous discrete summations. Results: These equations show that PM is equivalent to TCM if the pitch variation p(z) is proportional to 1/i(z), where i(z) is the local tube current. The simulations show that the local dose at z depends only weakly on the local tube current i(z) or local pitch p(z) due to scatter from all other locations along z, and that the “local CTDI{sub vol}(z)” or “CTDI{sub vol} per slice” do not represent a local dose but rather only a relative i(z) or p(z). The CTDI-paradigm does not apply to shift-variant techniques and the scanner-reported CTDI{sub vol} for the same lacks physical significance and relevance. Conclusions: While the traditional CTDI{sub vol} at constant tube current and pitch conveys useful information (the peak dose at the center of the scan length), CTDI{sub vol} for shift-variant techniques (TCM or PM) conveys no useful information about the associated dose

  19. Finding Critical Sets.

    DTIC Science & Technology

    1985-09-13

    Donald I .Lvln 4uk Unvrs’ Doal W. Loveland ’F~ t,4 . . * ’ 4 F ~ F 4 ~. s F 1’%j ELECTE’ DEPATMENT 󈧰 * *’ ,Ud ’ fmiiPuii reJ~ SCIECE LiJ P...4. CONTRACT ON GRANT NUMBER(,) AFOSR 83-0205 .iZ D.W. Loveland S. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT, PROJECT . TASK AREA...variants thereof, were implemented to observe relative perfor- mance qualitatively, to allow some idea of performance relative to the upper bounds

  20. Combined Operations in the Korean War

    DTIC Science & Technology

    1989-04-24

    Research Cfice, 1952. Ministry of National Defense , Republic of Korea . The History of United Nations Forces in the Korean War. Volume VI, Seou 1: 1977. ,-,h...committed to repelling the North Korean and Chinese armies from the Republic of Korea (ROK). The Korean War was not anticipated and neither was the extent...Coaal: tior War Early on 25 June Iz)50 the North Korean People- Army =_NKPA launched an overwhelming invasion into the Repu’Tli,: cf Korea . Pres-.i,ent

  1. THz semiconductor-based front-end receiver technology for space applications

    NASA Technical Reports Server (NTRS)

    Mehdi, Imran; Siegel, Peter

    2004-01-01

    Advances in the design and fabrication of very low capacitance planar Schottky diodes and millimeter-wave power amplifiers, more accurate device and circuit models for commercial 3-D electromagnetic simulators, and the availability of both MEMS and high precision metal machining, have enabled RF engineers to extend traditional waveguide-based sensor and source technologies well into the TI-Iz frequency regime. This short paper will highlight recent progress in realizing THz space-qualified receiver front-ends based on room temperature semiconductor devices.

  2. Overview of High-Temperature Superconductivity: Theory, Surfaces, Interfaces and Bulk Systems

    DTIC Science & Technology

    1988-06-01

    superconductivity. The RVB theory has been amplified or modified in several ways [5,6,7], the details of which we won’t go into here. Rice and Wang [8] have...similar to those of RVB theory, but different from BCS theory. Rice and Wang , however, favor a phonon interaction which mediates the attraction between...36, 857. 7. Kotliar, G. Phys. Rev. B,1988, IZ, 3664. 8. Rice, M. J.; Wang , Y. R. Phys. Rev.-B, 1988, 37, 5893. 9. Coffey, L.; Cox, D. L. Phys. Rev

  3. Investigation of the Hypersonic Flowfield Surrounding a Shaped Charge Jet.

    DTIC Science & Technology

    1987-12-01

    0CONTINUEi ENTH-H*RGAS 0 CPR1-0.0 CPR2-0.O DO 91 MM-1,11 TEMP1-X(MM) *CV (MM) TEMP2-X(MM) *CP(MM) CVR1-CVR-4TEMP1 CPR1- CPRI +TEMP2 91 CONTINUE DO 94 IZ-1,11...DO 90 1-1,11 SAVE-X(I)*(LMEO(I)+(TETH(I)/T)) 4 ERT-ERT+SAVE 90 CONTINUE ZHRT- (ERT*Z) +Z H-(ZHRT*T) ENTH-H*RGAS CVRI-0.0 CVR2-0.0 CPRI -0.0 CPR2-0.0 DO

  4. Isolation and identification of trans-2- and trans-3-hydroxy-1,8-cineole glucosides from Alpinia galanga.

    PubMed

    Someya, Y; Kobayashi, A; Kubota, K

    2001-04-01

    Three hydroxy-1,8-cineole glucopyranosides, (1R, 2R, 4S)- and (1S, 2S, 4R)-trans-2-hydroxy-1,8-cineole beta-D-glucopyranosides, and (1R, 3S, 4S)-trans-3-hydroxy-1,8-cineole beta-D-glucopyranoside, which are possible precursors of acetoxy-1,8-cineoles as unique aroma components, were isolated from the rhizomes of greater galangal (Alpinia galanga W.). Their structures were analyzed by FAB-MS and NMR spectrometry, and the absolute configulation of each aglycone was determined by using a GC-MS analysis with a capillary column coated with a chiral stationary phase. The composition of the diastereomers of (1R, 2R, 4S)- and (1S, 2S, 4R)-trans-2-hydroxy-1,8-cineole beta-D-glucopyranosides in the rhizomes was determined as 3:7 by a GC-MS analysis after preparing the trifluoroacetate derivatives of the glucosides.

  5. Structure determination of myrtenal by microwave spectroscopy and quantum chemical calculations

    NASA Astrophysics Data System (ADS)

    Chrayteh, Mhamad; Dréan, Pascal; Huet, Thérèse R.

    2017-06-01

    The rotational spectrum of myrtenal has been investigated using a Fourier transform microwave spectrometer coupled to a supersonic expansion in the 2-20 GHz frequency range. Of the two possible conformers expected in the gas phase, only the s-trans conformer which was calculated 12kJmol-1 lower in energy than the s-cis conformer was observed. The spectra of the ten 13C and 18O isotopic species of s-trans-myrtenal were observed in natural abundance. The ground state rotational constants are A = 1666.269706 (55)MHz, B = 962.344291 (40)MHz and C = 836.903508 (43)MHz . A partial rs structure was calculated using Kraitchman's equations. A r0 structure was also derived using additional data from a B3LYP/6-311++G(d,p) calculation. The structural parameters of the sbnd Cdbnd Csbnd Cdbnd O pattern of myrtenal (r0(Cdbnd C) = 1.341(16) Å, r0(Csbnd C) = 1.479(98) Å, r0(Cdbnd O) = 1.220(13) Å, ∠(OCC) = 124.4(13)° and ∠ (CCC) = 119.3 (11) °) are very close to those in trans-acrolein and in trans-trans-cinnamaldehyde.

  6. Synthesis, crystal structure, and spectral studies of 10-(2-Benzothiazolylazo)-9-phenanthrol

    SciTech Connect

    Davydov, V. V.; Sokol, V. I.; Polyanskaya, N. A.; Linko, R. V. Ryabov, M. A.; Sergienko, V. S.

    2012-03-15

    10-(2-Benzothiazolylazo)-9-phenanthrol (L) is prepared by a reaction of 2-hydrazinobenzothiazol with 9,10-phenanthrenequinone. The crystal and molecular structure of the L{center_dot}CHCl{sub 3} solvate is determined by X-ray diffraction. The data of the X-ray diffraction study, as well as IR, {sup 1}H NMR, and electronic absorption spectra, indicate that in the crystal state and solutions the L molecule exists in the form of a quinohydrazone tautomer (b) (s-trans, cis) stabilized by the intramolecular N{sub 2}-HN{sub 2} Horizontal-Ellipsis O1 hydrogen bond. The 'mobile' H atom is located at the N2 atom of the azo group. The benzothiazolyl and phenanthrenequinone fragments are nearly coplanar. Spectroscopic criteria for the state of L in various media are determined based on the data of IR, {sup 1}H NMR, and electronic absorption spectroscopy and the results of the Pariser-Parr-Pople quantum-chemical calculations.

  7. C dbnd N sbnd N dbnd C conformational isomers of 2'-hydroxyacetophenone azine: FTIR matrix isolation and DFT study

    NASA Astrophysics Data System (ADS)

    Grzegorzek, Joanna; Mielke, Zofia; Filarowski, Aleksander

    2010-07-01

    2'-hydroxyacetophenone azine (APA) has been studied by matrix isolation infrared spectroscopy and quantum chemical calculations. The DFT/B3LYP/6-311++G(2d,2p) calculations demonstrated the existence of two conformers for the lowest energy E/ E configuration of APA, a s- trans and a gauche ones. The conformers are characterized by similar energies and differ in the value of a C dbnd N sbnd N dbnd C angle, that was calculated to be 180° for a planar s-trans conformer and 155° for a non-planar gauche one . The calculated barrier for conformational interconversion is also very low, ca. 1 kJ mol -1 for the conversion from a gauche conformer to a trans one. The FTIR spectra of an argon matrix doped with APA from a vapour above solid sample evidence the presence of both conformers that exhibit reversible interconversion at matrix temperatures. The comparison of the theoretical spectra with the experimental ones and reversible temperature dependence of the experimental spectra allowed for unambiguous spectroscopic characterization of the trans and gauche conformers. The experiment also demonstrated that a gauche conformer is more stable than a trans one. The spectra analysis indicates that transformation from a trans conformer to a gauche one weakens the intramolecular O sbnd H⋯N bonds in the molecule.

  8. Computational study on the vinyl azide decomposition.

    PubMed

    Duarte, Darío J R; Miranda, Margarida S; Esteves da Silva, Joaquim C G

    2014-07-10

    The decomposition mechanism of vinyl azide (CH2CHN3) has been studied by calculations of the electronic structure. In addition, a study based on the topology of the electron charge density distribution and its Laplacian function, within the Quantum Theory of Atoms in Molecules (QTAIM), has been carried out with the aim of comprehending the electron redistribution mechanisms that take place in the formation of vinyl nitrenes. The electronic structure calculations reveal that the decomposition of the s-cis conformer of vinyl azide leads to the formation of ketenimine through a single-step conversion, s-cis-CH2CHN3 → CH2CNH + N2, while the conversion of the s-trans conformer to acetonitrile occurs in two steps, s-trans-CH2CHN3 → cyc-CH2NCH + N2 → CH3CN + N2. The topological analysis of the L(r) function reveals that triplet vinyl nitrene has one lone pair on the valence shell charge concentration (VSCC) of nitrogen and thus could act as a monodentate Lewis base, while singlet vinyl nitrene has two lone pairs on the VSCC of nitrogen and thus could act as a bidentate Lewis base.

  9. Lewis acid catalysis of photochemical reactions. 7. Photodimerization and cross-cycloaddition of cinnamic esters

    SciTech Connect

    Lewis, F.D.; Quillen, S.L.; Hale, P.D.; Oxman, J.D.

    1988-02-17

    The effects of Lewis acid complexation upon the molecular structure, solid-state photodimerization, and solution dimerization and cross-cycloaddition of cinnamic esters have been investigated. Comparison of crystal structures for free and SnCl/sub 4/-complexed ethyl cinnamate indicates that the enone double bonds are lengthened, the single bonds are shortened, and the enone conformation changes from s-cis to s-trans upon complexation. These changes are consistent with calculated changes in ..pi.. bonding and net charges. Solid-state photodimerization of free and complexed cinnamic esters and related molecules yield syn head-to-tail (..cap alpha..-truxillate) dimers. In most cases the Lewis acid complexes dimerize more efficiently and stereoselectively than the free esters. Photodimerization and cross-cycloaddition of methyl cinnamate in dilute solution is also catalyzed by Lewis acids. The mechanism of these reactions involves electronic excitation of a ground-state ester (dimerization) or simple olefin (cross cycloaddition). The catalytic effect of Lewis acids is attributed to an increase in excited-state lifetime and reactivity.

  10. Systematic conformational investigations of peptoids and peptoid-peptide chimeras.

    PubMed

    Brandt, Wolfgang; Herberg, Thomas; Wessjohann, Ludger

    2011-01-01

    Peptoids are originally defined as N-substituted oligoglycine derivatives, and in a broader definition as N-substituted peptides (peptoid-peptide chimeras). Both types were systematically investigated by force field calculations. The Merck MMFF and YASARA2 force fields were shown to be, among others, the most suitable ones for conformational investigations of peptoids with no missing parameterizations, in contrast to AMBER or CHARMM. Ramachandran-like plots were calculated for dipeptoids and chimeras using energy calculations and grid searches by varying the dihedral angels PHI and PSI in steps of 10 degrees for s-cis- and s-trans amide bonds. Barriers as well as low energy conformations are compared to peptide Ramachandran plots, showing that peptoids have both, more barriers due to additional steric interactions as well as access to minimum conformations not accessible by peptides. Low energy conformations of dimers were used as starting conformations of higher oligomers of the peptoids for extensive molecular dynamics simulations over 10 or 20 ns with the YASARA2 force field and an explicit water solvent box to evaluate their potential to form secondary structural elements. Especially peptoids with aminoisobutyric acid-like monomer units were found to form left-handed or polyproline-like helices also known from less common natural peptides. Furthermore, new secondary structures appear feasible based on stable conformations outside the allowed areas of the Ramachandran plot for peptides, but allowed for peptoids.

  11. 3-Acetyl-2-methyl-4-(pyridin-3-yl)-1,4-di­hydro­indeno­[1,2-b]pyridin-5-one

    PubMed Central

    Bisenieks, Imants; Mishnev, Anatoly; Bruvere, Imanta; Vigante, Brigita; Andzans, Zigmars

    2013-01-01

    In the title compound, C20H16N2O2, the condensed tricyclic fragment is near to planar, with an r.m.s. deviation of 0.0531 Å. The 1,4-di­hydro­pyridine (1,4-DHP) ring adopts a slightly puckered boat-like conformation. The N and opposite C atoms deviate from the least-squares plane of the four other ring atoms by 0.039 (3) and 0.141 (3) Å, respectively. The C=O group located at the tricyclic fragment is fixed in an s-trans orientation, while the second C=O group adopts an s-cis orientation with respect to the double bonds of the 1,4-DHP ring. The pyridine ring has a pseudo-axial orientation with respect to the 1,4-DHP ring. The dihedral angle between the tricyclic system and the pyridine ring is 77.3 (3)°. In the crystal, the pyridine N atom accepts a hydrogen bond from the N—H group of the 1,4-DHP ring. The hydrogen bonds link the mol­ecules into infinite C(8) chains along the b-axis direction. PMID:23723870

  12. [Obtaining transgenic rice plants and their progenies using Agrobacterium tumefaciens].

    PubMed

    Yin, Z C; Yang, F; Xu, Y; Li, B J

    1998-12-01

    Rice (Oriza sativa L.) suspension cells of Taipei 309 were co-cultivated with A. tumefaciens stran EHA101 harbouring binary vector pBYT2 for 3 days in the presence of vir inducer, 100 mumol/L acetosyringone (AS). After 2 months of continuous selection, 17 stable hygromycin-resistant, GUS-positive calli were recovered from 364 suspension cell clusters co-cultivated with A. tumefaciens. 10 putative transgenic R0 plants obtained from 8 tansformed calli and their progenies were analyzed for the integration and expression of foreign genes. Southern blot analysis of R0 and R1 generations indicated that foreign genes had been stably integrated in the genome of transgenic rice and sexually transmitted. One of the transgenic lines showed 5 copies of T-DNA integration, while the others had only one copy. Histochemical staining observation and fluorometric assay of GUS activity in transgenic rice cells and plants showed ubiquitin promoter from maize was highly effective in driving the expression of gus reporter gene in transgenic rice cells. GUS protein and its activity were also investigated through ndPAGE-X-Gluc staining assay, and it was found that the GUS protein in transgenic rice cells was smaller in size than the standard GUS protein (Sigma Co. G0786) but as large as that from E.coli HB101 (pBI121). This study suggested that Agrobacterium-mediated transformation of plant is an efficient and reliable method to introduce foreign genes into rice.

  13. Azulenium chemistry: towards new derivatives of photochromic dihydroazulenes.

    PubMed

    Petersen, Anne Ugleholdt; Jevric, Martyn; Elm, Jonas; Olsen, Stine T; Tortzen, Christian G; Kadziola, Anders; Mikkelsen, Kurt V; Nielsen, Mogens Brøndsted

    2016-02-28

    Here we present the preparation of a selection of azulenium ions by hydride abstraction from photochromic 1,8a-dihydroazulenes (1,8a-DHAs) incorporating two cyano groups at C-1. The reactivity of the electrophilic tropylium ring of these molecules towards lithium triisopropylsilylacetylide was investigated. The position of attack by the nucleophile depended on the substitution pattern of the azulenium cation but was in general found to occur preferentially at positions C-4, C-5, and C-6, and to a minor extent at positions C-7 and C-8. The outcome was a mixture of non-photochromic, regioisomeric DHAs. One of these compounds containing the ethynyl substituent at position C-4 was partly tautomerized to the photochromic 1,8a-dihydroazulene, which was isolated and its switching properties were investigated by UV-Vis absorption spectroscopy. Upon irradiation, it undergoes a ring-opening reaction to form a vinylheptafulvene (VHF), which in turn returns to the original DHA. The half-life of this reaction was significantly smaller than for a derivative with the alkynyl substituent placed at C-7. This fast switching behavior was according to the calculations explained by an enhancement in the stability of the reactive s-cis conformer of the VHF relative to the, still more stable, s-trans conformer, and by a smaller activation energy for this s-cis conformer to undergo ring-closure.

  14. Rotational Spectroscopy of Methyl Vinyl Ketone

    NASA Astrophysics Data System (ADS)

    Zakharenko, Olena; Motiyenko, R. A.; Aviles Moreno, Juan-Ramon; Huet, T. R.

    2015-06-01

    Methyl vinyl ketone, MVK, along with previously studied by our team methacrolein, is a major oxidation product of isoprene, which is one of the primary contributors to annual global VOC emissions. In this talk we present the analysis of the rotational spectrum of MVK recorded at room temperature in the 50 -- 650 GHz region using the Lille spectrometer. The spectroscopic characterization of MVK ground state will be useful in the detailed analysis of high resolution infrared spectra. Our study is supported by high level quantum chemical calculations to model the structure of the two stable s-trans and s-cis conformers and to obtain the harmonic force field parameters, internal rotation barrier heights, and vibrational frequencies. In the Doppler-limited spectra the splittings due to the internal rotation of methyl group are resolved, therefore for analysis of this molecule we used the Rho-Axis-Method Hamiltonian and RAM36 code to fit the rotational transitions. At the present time the ground state of two conformers is analyzed. Also we intend to study some low lying excited states. The analysis is in progress and the latest results will be presented. Support from the French Laboratoire d'Excellence CaPPA (Chemical and Physical Properties of the Atmosphere) through contract ANR-10-LABX-0005 of the Programme d'Investissements d'Avenir is acknowledged.

  15. Determination of chromophore structure and environment in bovine visual pigments with resonance Raman spectroscopy

    SciTech Connect

    Palings, H.A.

    1987-01-01

    Resonance Raman spectra of /sup 2/H- and /sup 13/C-labeled visual pigments have been obtained and analyzed. The C-C stretching vibrations of rhodopsin, isorhodopsin, and bathorhodopsin have been assigned, as well as those of the 11-cis and 9-cis retinal protonated Schiff base model compounds. The insensitivity of the C/sub 14/-C/sub 15/ stretch frequency to N-deuteration in all three pigments demonstrates that each contains a trans C=N bond. Comparison of the fingerprint modes of the visual pigments and their model compounds shows that the C/sub 10/-C/sub 11/ and C/sub 14/-C/sub 15/ single bonds are s-trans in all three pigments. This provides evidence against the model of bathorhodopsin proposed by Lui and Asato, which suggests a C/sub 10/-C/sub 11/ s-cis structure. The extreme similarity of the C-C stretch modes of rhodopsin and the 11-cis retinal protonated Schiff base argues against the presence of a negatively charged protein residue near C/sub 13/, proposed to be responsible for the opsin shift of rhodopsin. However, the unusually large shift of the C=N stretch frequency upon N-deuteration in rhodopsin relative to the model compound suggests that the opsin shift mechanism may involve altered Schiff base - counter ion interactions.

  16. Structure and conformations of isoprene by vibrational spectroscopy and gas electron diffraction

    NASA Astrophysics Data System (ADS)

    Traetteberg, M.; Paulen, G.; Cyvin, S. J.; Panchenko, Yu. N.; Mochalov, V. I.

    1984-04-01

    The structure of the isoprene (2-methyl-buta-1,3-diene) molecule has been studied by vibrational spectroscopy and gas electron diffraction techniques. A normal coordinate analysis was used to calculate the vibrational frequencies for the anti ( s-trans), gauche and syn ( s-cis) conformers of the molecule. Assignments of some frequencies of the anti form were revised. The experimental bands at 1255, 635, 555, 419 and 311 cm -1 are assigned as fundamentals of the gauche conformer with a high degree of confidence. Among the structural parameters determined by electron diffraction are the following bond distances (in Å): CC 1.340, CC 1.463, CC methyl 1.512, CH 1.076 and CmethylH 1.110. The abundance of the anti form was determined to be 95.3%, while the rest (4.7%) was interpreted as the gauche form with a dihedral angle of 73.5°.

  17. Enantio- and diastereoselectivities in chiral sulfur ylide promoted asymmetric aziridination reactions.

    PubMed

    Janardanan, Deepa; Sunoj, Raghavan B

    2008-11-07

    Density functional theory investigation on the factors controlling enantio- and diastereoselection in asymmetric aziridination reaction by the addition of chiral bicyclic sulfur ylides to substituted aldimines is presented. High levels of enantioselection are predicted toward the formation of (2S,3S)-cis and (2R,3S)-trans aziridines by the addition of stabilized ylide (R = COMe) respectively to SO2Me and CO2Me protected aldimines. Similarly, high %ee is predicted for the formation of (2S,3R)-cis aziridines from semistabilized (R = Ph) ylide. Moderate to high levels of diastereoselectivity is noticed as well. The present study highlights that a correct prediction on extent of enantioselection requires the knowledge of the activation barriers for elementary steps beyond the initial addition step. In the case of stabilized ylides the ring-closure (or elimination of sulfur compound) is found to be crucial in controlling enantio- and diastereoselection. A cumulative effect of electronic as well as other weak interactions is identified as factors contributing to the relative energies of transition states leading to enantio- and diastereomeric products for the stabilized ylide addition to aldimines. On the contrary, steric control appears quite dominant with semistabilized ylide addition. With the smallest substituent on ylide (R = Me), high enantioselectivity is predicted for the formation of (2R,3R)-trans aziridines although the %de in this case is found to be very low.

  18. Torsion-rotation-vibration effects in the ground and first excited states of methacrolein, a major atmospheric oxidation product of isoprene

    SciTech Connect

    Zakharenko, O.; Motiyenko, R. A.; Aviles Moreno, J.-R.; Huet, T. R.; Jabri, A.; Kleiner, I.

    2016-01-14

    Methacrolein is a major oxidation product of isoprene emitted in the troposphere. New spectroscopy information is provided with the aim to allow unambiguous identification of this complex molecule, characterized by a large amplitude motion associated with the methyl top. State-of-the-art millimeter-wave spectroscopy experiments coupled to quantum chemical calculations have been performed. For the most stable s-trans conformer of atmospheric interest, the torsional and rotational structures have been characterized for the ground state, the first excited methyl torsional state (ν{sub 27}), and the first excited skeletal torsional state (ν{sub 26}). The inverse sequence of A and E tunneling sub-states as well as anomalous A-E splittings observed for the rotational lines of v{sub 26} = 1 state clearly indicates a coupling between methyl torsion and skeletal torsion. A comprehensive set of molecular parameters has been obtained. The far infrared spectrum of Durig et al. [Spectrochim. Acta, Part A 42, 89–103 (1986)] was reproduced, and a Fermi interaction between ν{sub 25} and 2ν{sub 27} was evidenced.

  19. Molecular dynamics investigation of primary photoinduced events in the activation of rhodopsin.

    PubMed Central

    Saam, Jan; Tajkhorshid, Emad; Hayashi, Shigehiko; Schulten, Klaus

    2002-01-01

    Retinal cis-trans isomerization and early relaxation steps have been studied in a 10-ns molecular dynamics simulation of a fully hydrated model of membrane-embedded rhodopsin. The isomerization, induced by transiently switching the potential energy function governing the C(11)==C(12) dihedral angle of retinal, completes within 150 fs and yields a strongly distorted retinal. The most significant conformational changes in the binding pocket are straightening of retinal's polyene chain and separation of its beta-ionone ring from Trp-265. In the following 500 ps, transition of 6s-cis to 6s-trans retinal and dramatic changes in the hydrogen bonding network of the binding pocket involving the counterion for the protonated Schiff base, Glu-113, occur. Furthermore, the energy initially stored internally in the distorted retinal is transformed into nonbonding interactions of retinal with its environment. During the following 10 ns, increased mobilities of some parts of the protein, such as the kinked regions of the helices, mainly helix VI, and the intracellular loop I2, were observed, as well as transient structural changes involving the conserved salt bridge between Glu-134 and Arg-135. These features prepare the protein for major structural transformations achieved later in the photocycle. Retinal's motion, in particular, can be compared to an opening turnstile freeing the way for the proposed rotation of helix VI. This was demonstrated by a steered molecular dynamics simulation in which an applied torque enforced the rotation of helix VI. PMID:12496081

  20. Cif is negatively regulated by the TetR family repressor CifR.

    PubMed

    MacEachran, Daniel P; Stanton, Bruce A; O'Toole, George A

    2008-07-01

    We previously reported that the novel Pseudomonas aeruginosa toxin Cif is capable of decreasing apical membrane expression of the cystic fibrosis transmembrane conductance regulator (CFTR). We further demonstrated that Cif is capable of degrading the synthetic epoxide hydrolase (EH) substrate S-NEPC [(2S,3S)-trans-3-phenyl-2-oxiranylmethyl 4-nitrophenol carbonate], suggesting that Cif may be reducing apical membrane expression of CFTR via its EH activity. Here we report that Cif is capable of degrading the xenobiotic epoxide epibromohydrin (EBH) to its vicinal diol 3-bromo-1,2-propanediol. We also demonstrate that this epoxide is a potent inducer of cif gene expression. We show that the predicted TetR family transcriptional repressor encoded by the PA2931 gene, which is immediately adjacent to and divergently transcribed from the cif-containing, three-gene operon, negatively regulates cif gene expression by binding to the promoter region immediately upstream of the cif-containing operon. Furthermore, this protein-DNA interaction is disrupted by the epoxide EBH in vitro, suggesting that the binding of EBH by the PA2931 protein product drives the disassociation from its DNA-binding site. Given its role as a repressor of cif gene expression, we have renamed PA2931 as CifR. Finally, we demonstrate that P. aeruginosa strains isolated from cystic fibrosis patient sputum with increased cif gene expression are impaired for the expression of the cifR gene.

  1. Cif Is Negatively Regulated by the TetR Family Repressor CifR▿

    PubMed Central

    MacEachran, Daniel P.; Stanton, Bruce A.; O'Toole, George A.

    2008-01-01

    We previously reported that the novel Pseudomonas aeruginosa toxin Cif is capable of decreasing apical membrane expression of the cystic fibrosis transmembrane conductance regulator (CFTR). We further demonstrated that Cif is capable of degrading the synthetic epoxide hydrolase (EH) substrate S-NEPC [(2S,3S)-trans-3-phenyl-2-oxiranylmethyl 4-nitrophenol carbonate], suggesting that Cif may be reducing apical membrane expression of CFTR via its EH activity. Here we report that Cif is capable of degrading the xenobiotic epoxide epibromohydrin (EBH) to its vicinal diol 3-bromo-1,2-propanediol. We also demonstrate that this epoxide is a potent inducer of cif gene expression. We show that the predicted TetR family transcriptional repressor encoded by the PA2931 gene, which is immediately adjacent to and divergently transcribed from the cif-containing, three-gene operon, negatively regulates cif gene expression by binding to the promoter region immediately upstream of the cif-containing operon. Furthermore, this protein-DNA interaction is disrupted by the epoxide EBH in vitro, suggesting that the binding of EBH by the PA2931 protein product drives the disassociation from its DNA-binding site. Given its role as a repressor of cif gene expression, we have renamed PA2931 as CifR. Finally, we demonstrate that P. aeruginosa strains isolated from cystic fibrosis patient sputum with increased cif gene expression are impaired for the expression of the cifR gene. PMID:18458065

  2. Hydroxyapatite catalyzed aldol condensation: synthesis, spectral linearity, antimicrobial and insect antifeedant activities of some 2,5-dimethyl-3-furyl chalcones.

    PubMed

    Subramanian, M; Vanangamudi, G; Thirunarayanan, G

    2013-06-01

    A series of 2,5-dimethyl-3-furyl chalcones [2E-1-(2,5-dimethyl-3-furyl)-3-(substituted phenyl)-2-propen-1-ones] have been synthesized by Hydrotalcite catalyzed aldol condensation between 3-acetyl-2,5-dimethylfuron and substituted benzaldehydes. Yields of chalcones are more than 80%. These chalcones were characterized by their physical constants and spectral data. The group frequencies of infrared ν(cm(-1)) of CO s-cis and s-trans, CH in-plane and out of plane, CH=CH out of plane, C=C out of plane modes, NMR chemical shifts δ(ppm) of Hα, Hβ, CO, Cα and Cβ of these chalcones were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analyses. From the results of statistical analyses, the effects of substituents on the group frequencies are explained. Antibacterial, antifungal and insect antifeedant activities of these chalcones have been studied. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Alpha-ketoamides and alpha-ketocarbonyls: conformational analysis and development of all-atom OPLS force field.

    PubMed

    Kahn, K; Bruice, T C

    2000-08-01

    The molecular structures and barriers for the internal rotation around the OC-CO single bond in four alpha-ketoamides and eight alpha-ketocarbonyls have been determined from the MP3/aug-cc-pVDZ and MP2/aug-cc-pVDZ calculations. Alpha-ketocarbonyls with non-bulky substituents adopt planar conformations with two carbonyl oxygens in s-trans arrangement. The s-cis conformation is significantly less stable due to the electrostatic repulsion between the two carbonyl groups. Primary and secondary alpha-ketoamides are planar when the substituent at the carbonyl carbon is hydrogen or methyl group but tertiary alpha-ketoamides adopt a conformation where the OC-CO unit is significantly bent. Based on current ab initio structural data, a set of OPLS-AA force field parameters has been derived. These parameters can be used for the modeling of a variety of alpha-ketoamide or alpha-ketocarbonyl containing drugs such as novel protease inhibitors or neuroregenerative polyketides.

  4. Torsion-rotation-vibration effects in the ground and first excited states of methacrolein, a major atmospheric oxidation product of isoprene

    NASA Astrophysics Data System (ADS)

    Zakharenko, O.; Motiyenko, R. A.; Aviles Moreno, J.-R.; Jabri, A.; Kleiner, I.; Huet, T. R.

    2016-01-01

    Methacrolein is a major oxidation product of isoprene emitted in the troposphere. New spectroscopy information is provided with the aim to allow unambiguous identification of this complex molecule, characterized by a large amplitude motion associated with the methyl top. State-of-the-art millimeter-wave spectroscopy experiments coupled to quantum chemical calculations have been performed. For the most stable s-trans conformer of atmospheric interest, the torsional and rotational structures have been characterized for the ground state, the first excited methyl torsional state (ν27), and the first excited skeletal torsional state (ν26). The inverse sequence of A and E tunneling sub-states as well as anomalous A-E splittings observed for the rotational lines of v26 = 1 state clearly indicates a coupling between methyl torsion and skeletal torsion. A comprehensive set of molecular parameters has been obtained. The far infrared spectrum of Durig et al. [Spectrochim. Acta, Part A 42, 89-103 (1986)] was reproduced, and a Fermi interaction between ν25 and 2ν27 was evidenced.

  5. Comparison of Diagnostic Accuracy of Real-Time Elastography and Shear Wave Elastography in Differentiation Malignant From Benign Thyroid Nodules.

    PubMed

    Tian, Wuguo; Hao, Shuai; Gao, Bo; Jiang, Yan; Zhang, Shu; Guo, Lingji; Gu, Lingji; Luo, Donglin

    2015-12-01

    Thyroid nodules are relatively more prevalent in iodine-deficiency area, and the incidence increased sharply in the past decade in these areas. Workup of malignant from benign nodules in clinic was the main problem for managing thyroid nodules.An overall search for the articles about the diagnostic performance of real-time elastography (RTE) and shear wave elastography (SWE) before April 2015 in the databases of PubMed, Embase, and Google scholar. The pooled sensitivity, specificity, and summary receiver operating characteristic (SROC) curve were obtained from individual studies with a random-effects model. Subgroup and meta-regression analysis were also performed.Fifty-six studies involved in 2621 malignant nodules and 7380 benign nodules were contained in our meta-analysis. The pooled sensitivity and specificity of RTE was 83.0% and 81.2%, which is higher than SWE (sensitivity: 78.7%, specificity: 80.5%). The areas under the SROC curve of RTE and SWE were 0.885 and 0.842 respectively. RTE had higher diagnostic value for Caucasians than Asians. Stran ratio (SR) assessment had higher diagnostic performance than elasticity score (ES) system. Similarly, it had higher diagnostic value when malignant nodules were more than 50.In summary, the results revealed that RTE had higher diagnostic performance than SWE in differentiating malignant from benign nodules. However, future international multicenter studies in the region of thyroid risk need to further assess the diagnostic performance of RTE.

  6. Micro-Raman spectroscopy study of the effect of Mid-Ultraviolet radiation on erythrocyte membrane.

    PubMed

    Li, N; Li, S X; Guo, Z Y; Zhuang, Z F; Li, R; Xiong, K; Chen, S J; Liu, S H

    2012-07-02

    Mid-Ultraviolet (UVB) has a significant influence on human health. In this study, human erythrocytes were exposed to UVB to investigate the effects of UVB radiation on erythrocytes membrane. And Micro-Raman spectroscopy was employed to detect the damage. Principal component analysis (PCA) was used to classify the control erythrocytes and the irradiated erythrocytes. Results showed that the erythrocytes membrane was damaged by Mid-Ultraviolet (UVB) radiation. The intensity of the Raman peaks at 1126 cm(-1) and 1082 cm(-1) were used to calculate the Longitudinal Order-Parameters in Chains (S(trans)) which can present the liquidity and ionic permeability of erythrocyte membrane. After UVB radiation for 30 min, both the liquidity and ionic permeability decreased. At the same time, the intensity of the peaks at 1302 cm(-1) (α-helix), 1254 cm(-1) (random coil), 1452 cm(-1) and 1430 cm(-1) (CH(2)/CH(3) stretch) have also changed which indicated the membrane protein also been damaged by UVB. In the whole process of radiation, the more UVB radiation dose the more damage on the erythrocyte membrane.

  7. Conformational Analysis of Retinoic Acids: Effects of Steric Interactions on Nonplanar Conjugated Polyenes

    PubMed Central

    Cox, Bryan D.; Muccio, Donald D.; Hamilton, Tracy P.

    2013-01-01

    Retinoic acids and other vitamin A analogs contain a trimethylcyclohexenyl ring in conjugation with a polyene chain joined at carbon-6 (C6) and carbon-7 (C7). A MP2-SCS/cc-pVDZ// B3LYP/6-31G(d) 2-D potential energy surface was computed for all-trans retinoic acid, which had 6 minima (3 enantiomeric pairs). The global minima were distorted s-gauche enantiomers (6–7 = 53°) with half-chair conformations of the ring. Distorted s-gauche enantiomers (6–7 = 55°) with inverted half-chair ring conformations were 1.7 kJ/mol above the global minima. The s-trans enantiomers (6–7 = 164°) were 11.3 kJ/mol above the global minima. Steric energies were computed by the method of Guo and Karplus to identify key structural elements in retinoic acids which determines their conformation. Small molecule crystal structures in the CCDC database with trimethylcyclohexenyl ring and exocyclic double bonds have ring-chain geometries near to one of the 6 energy minima of retinoic acids, except for retinaldehyde iminium cations. PMID:25798372

  8. Conformational Analysis of Retinoic Acids: Effects of Steric Interactions on Nonplanar Conjugated Polyenes.

    PubMed

    Cox, Bryan D; Muccio, Donald D; Hamilton, Tracy P

    2013-05-01

    Retinoic acids and other vitamin A analogs contain a trimethylcyclohexenyl ring in conjugation with a polyene chain joined at carbon-6 (C6) and carbon-7 (C7). A MP2-SCS/cc-pVDZ// B3LYP/6-31G(d) 2-D potential energy surface was computed for all-trans retinoic acid, which had 6 minima (3 enantiomeric pairs). The global minima were distorted s-gauche enantiomers (6-7 = 53°) with half-chair conformations of the ring. Distorted s-gauche enantiomers (6-7 = 55°) with inverted half-chair ring conformations were 1.7 kJ/mol above the global minima. The s-trans enantiomers (6-7 = 164°) were 11.3 kJ/mol above the global minima. Steric energies were computed by the method of Guo and Karplus to identify key structural elements in retinoic acids which determines their conformation. Small molecule crystal structures in the CCDC database with trimethylcyclohexenyl ring and exocyclic double bonds have ring-chain geometries near to one of the 6 energy minima of retinoic acids, except for retinaldehyde iminium cations.

  9. Enantioselectivity of hydroxylation of racemic piperitone by fungi.

    PubMed

    Grudniewska, Aleksandra; Gniłka, Radosław; Wawrzeńczyk, Czesław

    2010-11-01

    The biotransformation of racemic piperitone ((±)-1) was investigated using four strains of fungi selected in the screening procedure. The substrate was transformed by Botrytis cinerea AM235, Absidia cylindrospora AM336, Absidia coerulea AM93, and Absidia glauca AM177 into more polar metabolites. The transformation of racemic piperitone ((±)-1) catalyzed by B. cinerea AM235 gave 7-hydroxypiperitone (2) as the only product. The biotransformation of (±)-1 by A. cylindrospora AM336 afforded mixture of three products: (-)-(R)-7-hydroxypiperitone ((-)-2), (+)-(4S,6R)-trans-6-hydroxypiperitone ((+)-3), and (+)-(4R,6R)-cis-6-hydroxypiperitone ((+)-4). The transformation of this substrate ((±)-1) by A. coerulea AM93 gave (±)-7-hydroxypiperitone ((±)-2), (-)-(4R,6S)-trans-6-hydroxypiperitone (-)-3), and (-)-(4S,6S)-cis-6-hydroxypiperitone ((-)-4). The last strain studied, A. glauca AM177, converted racemic piperitone ((±)-1) to four products: (+)-(S)-7-hydroxypiperitone (2), (+)-(4S,6R)-trans-6-hydroxypiperitone ((+)-3), (±)-cis-6-hydroxypiperitone ((±)-4), and 8-hydroxypiperitone (5).

  10. Computational Examination of (4 + 3) versus (3 + 2) Cycloaddition in the Interception of Nazarov Reactions of Allenyl Vinyl Ketones by Dienes.

    PubMed

    Li, Zhe; Boyd, Russell J; Burnell, D Jean

    2015-12-18

    A computational examination of the tandem Nazarov/cycloaddition process involving an allenyl vinyl ketone with a diene has been carried out using the ωB97X-D/6-311++G(d,p)//ωB97X-D/6-31+G(d,p) method with solvation modeled by SMD-PCM. The barrier for the initial Lewis acid mediated Nazarov reaction, which provided the intermediate cyclic oxylallyl cation, was higher than that for any subsequent cycloaddition. The barrier for the first step of a subsequent stepwise reaction did not vary much with the diene, and the lowest barrier was with the diene in its s-trans conformation. Stepwise formation of a (4 + 3) cycloaddition product was not energetically feasible, but (3 + 2) cycloaddition products could have been produced through low energy pathways. The barrier for a concerted (4 + 3) cycloaddition did depend upon the diene, which was always in an s-cis geometry. The barriers for the compact and the extended geometries for the transition states of (4 + 3) cycloadditions were not much different.

  11. Acute Macular Neuroretinopathy Associated With Chikungunya Fever.

    PubMed

    Pang, Claudine E; Navajas, Eduardo V; Warner, Simon J; Heisler, Morgan; Sarunic, Marinko V

    2016-06-01

    A 47-year-old man with recent travel to the Caribbean was admitted with acute febrileillness associated with arthralgia and skin rash followed by sudden onset of bilateral visual field defects. Funduscopy revealed subtle bilateral paracentral dark lesions nasal to the fovea best seen on near infrared imaging as hyporeflective, wedge-shaped, paracentral macular lesions. Spectral-domain optical coherence tomography (SD-OCT) through the lesions revealed hyperreflective bands at the level of the outer plexiform layer and outer nuclear layer (ONL), with concomitant attenuation of the underlying external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ). Neither fluorescein angiography nor speckle variance OCT angiography (sv-OCTA) showed any defects in retinal circulation. Work up revealed positive Immunoglobulin M for Chikungunya virus (CHIKV). Six months later, the patient had persistent scotomas, although reduced in size. SD-OCT showed subtle ONL thinning and restoration of the ELM, although EZ and IZ remained disrupted. Chikungunya fever may manifest as bilateral acute macular neuroretinopathy (AMN). Clinicians should be aware of possible systemic associations of AMN. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:596-599.]. Copyright 2016, SLACK Incorporated.

  12. An algorithm for 353 odor detection thresholds in humans.

    PubMed

    Abraham, Michael H; Sánchez-Moreno, Ricardo; Cometto-Muñiz, J Enrique; Cain, William S

    2012-03-01

    One hundred and ninety three odor detection thresholds, ODTs, obtained by Nagata using the Japanese triangular bag method can be correlated as log (1/ODT) by a linear equation with R(2) = 0.748 and a standard deviation, SD, of 0.830 log units; the latter may be compared with our estimate of 0.66 log units for the self-consistency of Nagata's data. Aldehydes, acids, unsaturated esters, and mercaptans were included in the equation through indicator variables that took into account the higher potency of these compounds. The ODTs obtained by Cometto-Muñiz and Cain, by Cometto-Muñiz and Abraham, and by Hellman and Small could be put on the same scale as those of Nagata to yield a linear equation for 353 ODTs with R(2) = 0.759 and SD = 0.819 log units. The compound descriptors are available for several thousand compounds, and can be calculated from structure, so that further ODT values on the Nagata scale can be predicted for a host of volatile or semivolatile compounds.

  13. Innervation zones location and optimal electrodes position of obliquus internus and obliquus externus abdominis muscles.

    PubMed

    Boccia, Gennaro; Rainoldi, Alberto

    2014-02-01

    The assessment of abdominal muscles has became popular in recent years because the study of "core muscles" is now considered a pivotal approach for a number of fields. The purpose of this study was to describe the innervation zone (IZ) locations and optimal electrode sites in two core muscles: the obliquus externus (OE) and the obliquus internus (OI) abdominis muscles. Twenty healthy male subjects were recruited and the IZ location was studied during a submaximal isometric contraction using multichannel surface EMG. The optimal electrode position for OI was found to be 2cm lower the most prominent point of the anterior superior iliac spine, just medial and superior to the inguinal ligament. The optimal electrode position for OE was found to be 14cm from the median line, lower the level of 1cm above umbilicus, parallel to the line extending from the most inferior point of the costal margin to the opposite pubic tubercle (almost 45° with respect to the median line). Findings showed that for OI and OE muscles it is possible to provide indications for a muscle belly area suited for proper positioning of at least an electrode pair. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Re-evaluation of EMG-torque relation in chronic stroke using linear electrode array EMG recordings.

    PubMed

    Bhadane, Minal; Liu, Jie; Rymer, W Zev; Zhou, Ping; Li, Sheng

    2016-06-28

    The objective was to re-evaluate the controversial reports of EMG-torque relation between impaired and non-impaired sides using linear electrode array EMG recordings. Ten subjects with chronic stroke performed a series of submaximal isometric elbow flexion tasks. A 20-channel linear array was used to record surface EMG of the biceps brachii muscles from both impaired and non-impaired sides. M-wave recordings for bilateral biceps brachii muscles were also made. Distribution of the slope of the EMG-torque relations for the individual channels showed a quasi-symmetrical "M" shaped pattern. The lowest value corresponded to the innervation zone (IZ) location. The highest value from the slope curve for each side was selected for comparison to minimize the effect of electrode placement and IZ asymmetry. The slope was greater on the impaired side in 4 of 10 subjects. There were a weak correlation between slope ratio and strength ratio and a moderate to high correlation between slope ratio and M-wave ratio between two sides. These findings suggest that the EMG-torque relations are likely mediated and influenced by multiple factors. Our findings emphasize the importance of electrode placement and suggest the primary role of peripheral adaptive changes in the EMG-torque relations in chronic stroke.

  15. Antimicrobial Activity of a Neem Cake Extract in a Broth Model Meat System

    PubMed Central

    Del Serrone, Paola; Nicoletti, Marcello

    2013-01-01

    This work reports on the antimicrobial activity of an ethyl acetate extract of neem (Azadirachta indica) cake (NCE) against bacteria affecting the quality of retail fresh meat in a broth model meat system. NCE (100 µg) was also tested by the agar disc diffusion method. It inhibited the growth of all tested microorganisms. The NCE growth inhibition zone (IZ) ranged 11.33–22.67 mm while the ciprofloxacin (10 µg) IZ ranged from 23.41–32.67 mm. There was no significant difference (p ≤ 0.05) between the antimicrobial activity of NCE and ciprofloxacin vs. C. jejuni and Leuconostoc spp. The NCE antibacterial activity was moreover determined at lower concentrations (1:10–1:100,000) in micro-assays. The percent growth reduction ranged from 61 ± 2.08–92 ± 3.21. The higher bacterial growth reduction was obtained at 10 µg concentration of NCE. Species-specific PCR and multiplex PCR with the DNA dye propidium monoazide were used to directly detect viable bacterial cells from experimentally contaminated meat samples. The numbers of bacterial cells never significantly (p ≤ 0.05) exceeded the inocula concentration used to experimentally contaminate the NCE treated meat. This report represents a screening methodology to evaluate the antimicrobial capability of a herbal extract to preserve meat. PMID:23917814

  16. High-P metamorphic rocks from the Himalaya and their tectonic implication ? a review

    NASA Astrophysics Data System (ADS)

    Jan, M. Qasim

    The suture zones bordering the Indian subcontinent on the E, N and W are characterized in several places by the occurrence of ophiolitic complexes and tectonic melanges. High-P metamorphic rocks have recently been discovered in the melanges in Burma, Naga Hills, southern Tibet, eastern and western Ladakh, Kohistan (Jijal, Allai, Shangla) and Khost (Afghanistan). The development of these rocks has an important bearing on the plate tectonics of the Himalaya. The High-P metamorphic rocks belong to prehnite-pumpellyite, blueschist and high-P greenschist facies but extensive garnet-granulites have developed at 35 km depth in Jijal. In the Indus-Zangbo suture zone (IZS) the high-P metamorphism is complemented to the N by low- or medium-P metamorphism and calc-alkaline magmatism in Tibet, Ladakh as well as Kohistan. High-P metamorphism in Jijal has been dated at 104 Ma, in Shangla at 70-100 Ma and in western Ladakh during mid-Cretaceous. Elsewhere, the timing of the high-P metamorphism is not known but a Cretaceous age is inferred. Since collision along the IZS occurred during Eocene, the high-P metamorphism is therefore related to the northwards subduction of the neo-Tethyan lithosphere under Tibet or late Mesozoic magmatic arcs. The timing of high-P metamorphism coincides with the breakup of India from Gondwanaland and its rapid northwards movement, whereas the tectonic melanges may principally have formed during Eocene collision and obduction.

  17. Nanog expression in heart tissues induced by acute myocardial infarction.

    PubMed

    Luo, Huanhuan; Li, Qiong; Pramanik, Jogen; Luo, Jiankai; Guo, Zhikun

    2014-10-01

    Nanog is a potential stem cell marker and is considered a regeneration factor during tissue repair. In the present study, we investigated expression patterns of nanog in the rat heart after acute myocardial infarction by semi-quantitative RT-PCR, immunohistochemistry and Western blot analyses. Our results show that nanog at both mRNA and protein levels is positively expressed in myocardial cells, fibroblasts and small round cells in different myocardial zones at different stages after myocardial infarction, showing a spatio-temporal and dynamic change. After myocardial infarction, the nanog expression in fibroblasts and small round cells in the infarcted zone (IZ) is much stronger than that in the margin zone (MZ) and remote infarcted zone (RIZ). From day 7 after myocardial infarction, the fibroblasts and small cells strongly expressed nanog protein in the IZ, and a few myocardial cells in the MZ and the RIZ and the numbers of nanog-positive fibroblasts and small cells reached the highest peak at 21 days after myocardial infarction, but in this period the number of nanog-positive myocardial cells decreased gradually. At 28 days after myocardial infarction, the numbers of all nanog-positive cells decreased into a low level. Therefore, our data suggest that all myocardial cells, fibroblasts and small round cells are involved in myocardial reconstruction after cardiac infarction. The nanog-positive myocardial cells may respond to early myocardial repair, and the nanog-positive fibroblasts and small round cells are the main source for myocardial reconstruction after cardiac infarction.

  18. Tailoring the optimal control cost function to a desired output: application to minimizing phase errors in short broadband excitation pulses.

    PubMed

    Skinner, Thomas E; Reiss, Timo O; Luy, Burkhard; Khaneja, Navin; Glaser, Steffen J

    2005-01-01

    The de facto standard cost function has been used heretofore to characterize the performance of pulses designed using optimal control theory. The freedom to choose new, creative quality factors designed for specific purposes is demonstrated. While the methodology has more general applicability, its utility is illustrated by comparison to a consistently chosen example--broadband excitation. The resulting pulses are limited to the same maximum RF amplitude used previously and tolerate the same variation in RF homogeneity deemed relevant for standard high-resolution NMR probes. Design criteria are unchanged: transformation of I(z)--> I(x) over resonance offsets of +/-20 kHz and RF variability of +/-5%, with a peak RF amplitude equal to 17.5 kHz. However, the new cost effectively trades a small increase in residual z magnetization for improved phase in the transverse plane. Compared to previous broadband excitation by optimized pulses (BEBOP), significantly shorter pulses are achievable, with only marginally reduced performance. Simulations transform I(z) to greater than 0.98 I(x), with phase deviations of the final magnetization less than 2 degrees, over the targeted ranges of resonance offset and RF variability. Experimental performance is in excellent agreement with the simulations.

  19. C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.

    PubMed

    Shah, Bhavin; Lutter, Daniela; Bochenek, Magdalena L; Kato, Katsuhiro; Tsytsyura, Yaroslav; Glyvuk, Natalia; Sakakibara, Akira; Klingauf, Jürgen; Adams, Ralf H; Püschel, Andreas W

    2016-01-01

    The establishment of a polarized morphology is essential for the development and function of neurons. During the development of the mammalian neocortex, neurons arise in the ventricular zone (VZ) from radial glia cells (RGCs) and leave the VZ to generate the cortical plate (CP). During their migration, newborn neurons first assume a multipolar morphology in the subventricular zone (SVZ) and lower intermediate zone (IZ). Subsequently, they undergo a multi-to-bipolar (MTB) transition to become bipolar in the upper IZ by developing a leading process and a trailing axon. The small GTPases Rap1A and Rap1B act as master regulators of neural cell polarity in the developing mouse neocortex. They are required for maintaining the polarity of RGCs and directing the MTB transition of multipolar neurons. Here we show that the Rap1 guanine nucleotide exchange factor (GEF) C3G (encoded by the Rapgef1 gene) is a crucial regulator of the MTB transition in vivo by conditionally inactivating the Rapgef1 gene in the developing mouse cortex at different time points during neuronal development. Inactivation of C3G results in defects in neuronal migration, axon formation and cortical lamination. Live cell imaging shows that C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process.

  20. Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone.

    PubMed

    Hatanaka, Yumiko; Yamauchi, Kenta

    2013-01-01

    The formation of axon-dendrite polarity is crucial for neuron to make the proper information flow within the brain. Although the processes of neuronal polarity formation have been extensively studied using neurons in dissociated culture, the corresponding developmental processes in vivo are still unclear. Here, we illuminate the initial steps of morphological polarization of excitatory cortical neurons in situ, by sparsely labeling their neuroepithelial progenitors using in utero electroporation and then examining their neuronal progeny in brain sections and in slice cultures. Morphological analysis showed that an axon-like long tangential process formed in progeny cells in the intermediate zone (IZ). Time-lapse imaging analysis using slice culture revealed that progeny cells with multipolar shape, after alternately extending and retracting their short processes for several hours, suddenly elongated a long process tangentially. These cells then transformed into a bipolar shape, extending a pia-directed leading process, and migrated radially leaving the tangential process behind, which gave rise to an "L-shaped" axon. Our findings suggest that neuronal polarity in these cells is established de novo from a nonpolarized stage in vivo and indicate that excitatory cortical neurons with multipolar shape in the IZ initiate axon outgrowth before radial migration into the cortical plate.

  1. All Prime Contract Awards by State or Country, Place, and Contractor. Part 2 (Agnew, California-Loma Linda, California)

    DTIC Science & Technology

    1990-01-01

    W #-- W 0. 0) 1-1 ZII4EI0 I I 0 C4 11 0 iz 0 cc 0 2 00 0oil mU 1 0 " 1I- TL -4 I- w N N- ~ -41- 1- f- N 0 Q11 is 0 0 I 0a 04 It U 0) 00 0 00U 0 C. 0...4Le -4 0 r-l’- 44 < 4’" .-4<<~*-4 -4 (A M-4 I -i 42 - iZ -4222 -42* -4 z -422 -4ZZ2222z -422 -42 * ~ to 000 fui Ia a ZZZ* IaZ* lu2 fuzz* 40222222* fiaZZ...11..J0() 20) 0000)00-1 00 .1 0O 000)4 1.-)))000 - I0) 0 -A 0) F UA u00 CD- W (-44 4 Wj 2 < <- 4c < mU (140N 442 N-Ŕ- F.- 0 0 1-- < I- w $-- C C0 U I

  2. Nanotribological response of a plasma nitrided bio-steel.

    PubMed

    Samanta, Aniruddha; Chakraborty, Himel; Bhattacharya, Manjima; Ghosh, Jiten; Sreemany, Monjoy; Bysakh, Sandip; Rane, Ramkrishna; Joseph, Alphonsa; Jhala, Ghanshyam; Mukherjee, Subroto; Das, Mitun; Mukhopadhyay, Anoop K

    2017-01-01

    AISI 316L is a well known biocompatible, austenitic stainless steel (SS). It is thus a bio-steel. Considering its importance as a bio-prosthesis material here we report the plasma nitriding of AISI 316L (SS) followed by its microstructural and nanotribological characterization. Plasma nitriding of the SS samples was carried out in a plasma reactor with a hot wall vacuum chamber. For ease of comparison these plasma nitrided samples were termed as SSPN. The experimental results confirmed the formations of an embedded nitrided metal layer zone (ENMLZ) and an interface zone (IZ) between the ENMLZ and the unnitrided bulk metallic layer zone (BMLZ) in the SSPN sample. These ENMLZ and IZ in the SSPN sample were richer in iron nitride (FeN) chromium nitride (CrN) along with the austenite phase. The results from nanoindentation, microscratch, nanoscratch and sliding wear studies confirmed that the static contact deformation resistance, the microwear, nanowear and sliding wear resistance of the SSPN samples were much better than those of the SS samples. These results were explained in terms of structure-property correlations.

  3. Further perspective on the theory of heteronuclear decoupling

    NASA Astrophysics Data System (ADS)

    Skinner, Thomas E.

    2014-11-01

    An exact general theory of heteronuclear decoupling is presented for spin-1/2 IS systems. RF irradiation applied to the I spins both modifies and generates additional couplings between states of the system. The recently derived equivalence between the dynamics of any N-level quantum system and a system of classical coupled harmonic oscillators makes explicit the exact physical couplings between states. Decoupling is thus more properly viewed as a complex intercoupling. The sign of antiphase magnetization plays a fundamental role in decoupling. A one-to-one correspondence is demonstrated between ± 2SyIz and the sense of the S-spin coupling evolution. Magnetization Sx is refocused to obtain the desired decoupled state when ∫ 2SyIz dt = 0 . The exact instantaneous coupling at any time during the decoupling sequence is readily obtained in terms of the system states, showing that the creation of two-spin coherence is crucial for reducing the effective scalar coupling, as required for refocusing to occur. Representative examples from new aperiodic sequences as well as standard cyclic, periodic composite-pulse and adiabatic decoupling sequences illustrate the decoupling mechanism. The more general aperiodic sequences, obtained using optimal control, realize the potential inherent in the theory for significantly improved decoupling.

  4. Semi-synthesis of new antimicrobial esters from the natural oleanolic and maslinic acids.

    PubMed

    Chouaïb, Karim; Hichri, Fayçal; Nguir, Asma; Daami-Remadi, Majda; Elie, Nicolas; Touboul, David; Ben Jannet, Hichem; Hamza, M'hamed Ali

    2015-09-15

    In this article, we report an effective procedure for the selective isolation of oleanolic acid 1 and maslinic acid 2 (3.4 and 8.5mg/g DW, respectively) from pomace olive (Olea europaea L.) using an ultrasonic bath, and the synthesis of a series of new triterpenic acid esters. The compounds were characterized by their spectral data and were evaluated for their antimicrobial activity. Among the compounds tested, those having sulfur and chlorine atoms were found to be antibacterial. They showed activity against two Gram-positive bacteria Staphylococcus aureus and Enterococcus faecalis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa (MICs within a range of 5-25μg/mL). The fungus Penicillium italicum was found to be the most sensitive to both sulfur derivatives: (3β)-3-((thiophene-2-carbonyl)oxy)-olean-12-en-28-oic acid (1a) (IZ=22mm) and (2α,3β-2,3-bis((thiophene-2-carbonyl)oxy)olean-12-en-28-oic acid (2a) (IZ=24mm).

  5. Exogenous Reelin modifies the migratory behavior of neurons depending on cortical location.

    PubMed

    Britto, Joanne M; Tait, Karen J; Lee, Ean Phing; Gamble, Robin S; Hattori, Mitsuharu; Tan, Seong-Seng

    2014-11-01

    Malformations of cortical development can arise when projection neurons generated in the germinal zones fail to migrate properly into the cortical plate. This process is critically dependent on the Reelin glycoprotein, which when absent leads to an inversion of cortical layers and blurring of borders. Reelin has other functions including supporting neuron migration and maintaining their trajectories; however, the precise role on glial fiber-dependent or -independent migration of neurons remains controversial. In this study, we wish to test the hypothesis that migrating cortical neurons at different levels of the cortical wall have differential responses to Reelin. We exposed neurons migrating across the cortical wall to exogenous Reelin and monitored their migratory behavior using time-lapse imaging. Our results show that, in the germinal zones, exogenous Reelin retarded neuron migration and altered their trajectories. This behavior is in contrast to the response of neurons located in the intermediate zone (IZ), possibly because Reelin receptors are not expressed in this zone. In the reeler cortex, Reelin receptors are expressed in the IZ and exposure to exogenous Reelin was able to rescue the migratory defect. These studies demonstrate that migrating neurons have nonequivalent responses to Reelin depending on their location within the cortical wall.

  6. Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil.

    PubMed

    Hajlaoui, Hafedh; Mighri, Hedi; Aouni, Mahjoub; Gharsallah, Néji; Kadri, Adel

    2016-06-01

    This study investigated the chemical composition and evaluated the antioxidant, antimicrobial, cytotoxic and anti-acetylcholinesterase properties of Tunisian Origanum majorana essential oil. The findings showed that the oil exhibited high activity, particularly in terms of reducing power and β-Carotene bleaching, inducing higher IC50 values than BHT. The oil showed an important antimicrobial activity against 25 bacterial and fungal strains. In fact, the IZ, MIC and MBC values recorded for the bacterial strains were in the range of 8 ± 0-18.33 ± 0.57 mm, 0.097-3.125 and 0.39-6.25 mg/mL, respectively. The IZ, MIC and MFC values of the fungal strains varied between 11±0-28 ± 0 mm, 0.058-0.468 mg/mL and 0.234-1.875 mg/mL, respectively. A low cytotoxic effect was observed against cancer (Hep-2 and HT29) and continuous cell lineage (Vero), with CC50 values ranging from 13.73 to 85.63 mg/mL. The oil was also evaluated for anti-acetylcholinesterase effects, which showed that it exhibited significant activity with IC50 values reaching 150.33 ± 2.02 μg/mL. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate.

    PubMed

    Singh, Bharat; Sharma, Ram A

    2015-01-01

    Heliotropium subulatum is an erect or procumbent perennial herb; leaves contain foliar trichomes and its resinous exudate is used in traditional medicine. The anti-inflammatory activity of dichloromethane fraction and isolated flavonoids was evaluated by using carrageenan and CFA-induced paw oedema models. Similarly, the disc diffusion and microdilution methods were used for the assessment of antimicrobial activity. Five isolated flavonoids were investigated for their antiinflammatory and antimicrobial activities. Eriodictyol demonstrated maximum anti-inflammatory activity (53.09%) at 30.0 mg/kg dose on 6(th) h and similarly, it inhibited the CFA-induced arthritis swelling (41.84%) with 30.0 mg/kg dose on 8(th) day respectively. As per disc diffusion and microdilution methods used for antimicrobial activity determination, the pinocembrin was found to be most active against Staphylococcus aureus (IZ=27±0.7 mm, 08 μg/ml dose) and Candida albicans (IZ=17±0.9 mm; 12 μg/ml dose). These investigated results revealed that the eriodictyol and pinocembrin showed significant anti-inflammatory and antimicrobial activities. Further studies which aimed to investigate the mechanism of action of these isolated flavonoids in the treatment of inflammations and various types of infections have been initiated.

  8. An ultrastructural study of connective tissue in mollusc integument III. Cephalopoda.

    PubMed

    Bairati, A; Comazzi, M; Gioria, M

    2003-06-01

    We studied structure and ultrastructure of the subepidermal connective tissue (SEC) of the integument of three cephalopods (Sepia officinalis, Octopus vulgaris and Loligo pealii). In all species, three distinct regions of the SEC were recognised: (a) an outer zone (OZ) that included the dermal-epidermal junction, and consisted of a thin layer of connective tissue containing muscles, (b) an extensive middle zone (MZ) containing a compact network of collagen fibres and numerous cells, (c) an inner zone (IZ) of loose connective tissue that merged with muscular fascia. This arrangement differs from that in bivalves and gastropods and recalls vertebrate integument. The dermal-epidermal junction of cephalopods differed from that of bivalves, gastropods and mammals in that the epidermal cells did not possess hemidesmosomes, and their intermediate filaments terminated directly in the plasmamembrane. The thick (120-500 nm) basal membrane (BM) had a superficial zone containing a regular array of granules; a lamina densa composed of a compact network of small filaments and granules; and an IZ distinguished by expansions of granular material protruding into underlying structures. Collagen fibres contained fibroblast-derived cytoplasmic thread, running through their centres and were surrounded by granular material that joins them to adjacent fibres. The collagen fibrils were of medium diameter (30-80 nm) had the typical ultrastructure of fibrillar collagens, and were surrounded by abundant interfibrillar material. The hypodermis was loose, with a network of small bundles of collagen fibrils. Cephalopod integument appears to represent a major evolutionary step distinguishing this class of molluscs.

  9. ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.

    PubMed

    Hirota, Yuki; Kubo, Ken-Ichiro; Fujino, Takahiro; Yamamoto, Tokuo T; Nakajima, Kazunori

    2016-11-30

    Neuronal migration contributes to the establishment of mammalian brain. The extracellular protein Reelin sends signals to various downstream molecules by binding to its receptors, the apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor and exerts essential roles in the neuronal migration and formation of the layered neocortex. However, the cellular and molecular functions of Reelin signaling in the cortical development are not yet fully understood. Here, to gain insight into the role of Reelin signaling during cortical development, we examined the migratory behavior of Apoer2-deficient neurons in the developing brain. Stage-specific labeling of newborn neurons revealed that the neurons ectopically invaded the marginal zone (MZ) and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone (IZ) in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners, that Rap1, integrin, and Akt are involved in the termination of migration beneath the MZ, and that Akt also controls neuronal migration in the IZ downstream of ApoER2. These data indicate that ApoER2 controls multiple processes in neuronal migration, including the early stage of radial migration and termination of migration beneath the MZ in the developing neocortex.

  10. Selection of a suitable plant for phytoremediation in mining artisanal zones.

    PubMed

    Chamba, I; Gazquez, M J; Selvaraj, T; Calva, J; Toledo, J J; Armijos, C

    2016-09-01

    A study was undertaken with the aim of identifying a suitable plant for the phytoremediation of metal-polluted soil from an artisanal mining area in Ecuador. Three zones including a natural zone (NZ), abandoned zone (AZ) and intensively mined zone (IZ) were selected. Three common native plants grown in the three zones were identified and collected, including Miconia zamorensis, Axonopus compressus and Erato polymnioides. The percentage of arbuscular mycorrhizal colonization that benefits their own survival in polluted soil was analyzed in the root samples of these candidate species. Analysis of the soils and plants collected from the different zones showed that the concentrations of Pb, Zn, Cu and Cd were comparatively lower in the NZ, higher in the AZ and IZ, and highest in the AZ for all the metals. The concentration of all these metals in plant tissues was the highest in E. polymnioides. The data analysis including the metal accumulation index, bioconcentration factor and translocation factor strongly identified E. polymnioides as a hyperaccumulator plant suitable for phytoremediation.

  11. Quantitative analysis of photoreceptor layer reflectivity on en-face optical coherence tomography as an estimator of cone density.

    PubMed

    Saleh, Maher; Flores, Mathieu; Gauthier, Anne Sophie; Elphege, Emeric; Delbosc, Bernard

    2017-08-08

    To investigate whether outer retinal reflectivity on en-face Optical coherence tomography (OCT) can be considered as an estimator of cone density measured in the same area. Forty-one points of comparisons were studied in 9 eyes (n = 6 patients) presenting maculopathies with various degrees of impairment of the photoreceptor layer. The inner segment ellipsoid zone (EZ), interdigitation zone (IZ), and retinal pigment epithelium (RPE) reflectivity were measured on coronal reconstruction of the photoreceptor layer using homemade dedicated software (Matlab, MathWorks Inc., Natick, USA). The cone metrics were measured in the same perifoveal region of interest using a high-resolution flood illumination adaptive optics camera. A semi-automatic cone counting method was adopted and all photoreceptor densities provided by the manufacturer's software were recounted manually by two experienced readers. Mean manual cone count was 21,522 ± 6700 (range, 5908-31,233 cells/mm(2)). Both EZ and IZ reflectivity values were closely correlated with cone density in the area studied (r(2): 0.80 and 0.62, respectively; p < 0.0001). Outer retinal reflectivity on en-face optical coherence tomography correlates well with photoreceptor density. This cone density estimation method based on retinal reflectivity could have interesting applications in the exploration and management of maculopathies.

  12. Electronegative plasma equilibria with spatially varying ionization

    NASA Astrophysics Data System (ADS)

    Kawamura, E.; Lichtenberg, A. J.; Lieberman, M. A.

    2012-12-01

    Electronegative inductive discharges in higher pressure ranges typically exhibit strongly localized ionization near the coil structure, with decay of the electron temperature and ionization into the central discharge region. We use a two-dimensional (2D) fluid code with a chlorine feedstock gas to determine the spatial profiles of the particle densities and electron temperature in a cylindrical transformer-coupled plasma device excited by a stove-top coil on top of the plasma chamber. To compare with one-dimensional (1D) analytical models, the 2D results are area-averaged over the radius. The area-averaged ionization frequency νiz is found to decay exponentially away from the coils, allowing the ansatz of an exponentially decaying axial variation for νiz to be used in a 1D numerical model. The 1D model captures the main features of the axial variations of the area-averaged 2D fluid simulation, indicating that the main diffusion mechanisms act along the axial direction. A simple analytical global discharge model is also developed, accounting for the asymmetric density and ionization profiles. The global model gives the scalings of the ion densities and electron temperature with power and pressure. The 1D and global models are compared with the 2D fluid simulations, showing reasonable agreement.

  13. Properties and partial genetic characterization of Nepean phage and other lytic phages of Brucella species.

    PubMed Central

    Rigby, C E; Cerqueira-Campos, M L; Kelly, H A; Surujballi, O P

    1989-01-01

    Nepean (Np), a new brucellaphage, was associated with atypical Brucella abortus strains from Ontario cattle. Carriage of Np was associated with loss of smooth lipopolysaccharide, changes in some protein bands in acrylamide gel electrophoresis profiles, increased susceptibility to colistin, and increased resistance to ultraviolet killing. Nepean (Np) was compared with brucellaphages Tb, Fi, Wb, Iz and R/C. All were morphologically identical, with icosahedral capsids (50-65 nm diameter) and short tails (15-25 nm long), but Np had a more restricted host range, replicating only in smooth strains of B. abortus. All six brucellaphages were generally similar in resistance to chemical and physical agents. Brucellaphage DNA was double stranded and unmethylated; its molecular size was 38 kilobase pairs. The DNAs of Tb, Fi, Wb, Iz and R/C could not be differentiated by restriction endonuclease digest profiles produced by BgII, EcoRI, HindIII or PvuII. Nepean (Np) DNA was very similar to that of the other brucellaphages, but with every enzyme used its profile differed in the number and/or position of at least one fragment. However, there was complete cross-hybridization of Tb and Np DNAs. Hybridization techniques failed to detect Brucella DNA in Dp or Tb phages, or phage DNA in Brucella cells. Extrachromosomal plasmid DNA was not detected. Images Fig. 1. Fig. 2. Fig. 3. Fig. 4. PMID:2504475

  14. State Estimation and Control of Conditionally Linear Systems,

    DTIC Science & Technology

    1984-04-01

    formula we have I: izv izv s t izv A t - e + iz f hl(T,y)e x (y))dT S t izv 2 t izv iz f e Tdv- f e Td . T 2 -s i.j .~~*.~ . - : r*-~ ----- K...3 (,y)dw T dv - f A 1(s,y)A 2Cs,y) A 3 (’,y)dw Tds 4..0 0 0 0 - . 7 2 S C (t,y,w) -- f A2(S,Y) f A3(s,y)dwds 50 0 W Note also that C4(t,y,w) and C5(t...1 22 30 0 2(0 3T (1.12) The arguments in (1.12) were omitted for brevity. From (1.8) it follows that t8 t * tD (x 0,wpy) (D t (xO+ A 6(t,y) + f A3 (s,y

  15. Re-evaluation of EMG-torque relation in chronic stroke using linear electrode array EMG recordings

    PubMed Central

    Bhadane, Minal; Liu, Jie; Rymer, W. Zev; Zhou, Ping; Li, Sheng

    2016-01-01

    The objective was to re-evaluate the controversial reports of EMG-torque relation between impaired and non-impaired sides using linear electrode array EMG recordings. Ten subjects with chronic stroke performed a series of submaximal isometric elbow flexion tasks. A 20-channel linear array was used to record surface EMG of the biceps brachii muscles from both impaired and non-impaired sides. M-wave recordings for bilateral biceps brachii muscles were also made. Distribution of the slope of the EMG-torque relations for the individual channels showed a quasi-symmetrical “M” shaped pattern. The lowest value corresponded to the innervation zone (IZ) location. The highest value from the slope curve for each side was selected for comparison to minimize the effect of electrode placement and IZ asymmetry. The slope was greater on the impaired side in 4 of 10 subjects. There were a weak correlation between slope ratio and strength ratio and a moderate to high correlation between slope ratio and M-wave ratio between two sides. These findings suggest that the EMG-torque relations are likely mediated and influenced by multiple factors. Our findings emphasize the importance of electrode placement and suggest the primary role of peripheral adaptive changes in the EMG-torque relations in chronic stroke. PMID:27349938

  16. Resiliency to social defeat stress relates to the inter-strain social interaction and is influenced by season variation.

    PubMed

    Han, Qiuqin; Yang, Liu; Liu, Yan; Lv, Ning; Yu, Jin; Wu, Gencheng; Zhang, Yuqiu

    2014-02-21

    Exposure to social defeat (SD) stress exerts social avoidance and depressive disorders. Little is known about the relationship between resiliency to stressors and the inter-strain social interaction (SI) level. We hypothesized that SD resiliency is correlated with a high SI between the same strain. C57BL/6J mice experienced a 10-day period of SD stress by repeated CD-1 mice offensive. The susceptible mice exhibited significant social-avoidance behaviors with less time in interaction-zone (IZ) and lower social interaction ratio (SIR) toward the Target (CD-1 mice), while resilient ones exhibited similar social interaction to control mice. When the Target was C57BL/6J mouse, either susceptible or resilient mice spent more time in IZ and the inter-strain SI in the resilient group was significantly higher than the susceptible. Correlation analysis revealed a significantly non-zero slope of the linear relationship between SIRs toward two strains. But different groups had a similar baseline of the inter-strain SI before stress, indicating a SD-induced defect in both types of SI. In addition, in four different seasons, animals exhibited a significant resiliency to the stress in summer. These data suggest that SD resiliency is related to a higher SI toward the same-strain, and may be regulated by seasonal variations.

  17. Bioactive coumarins from the roots and fruits of Ferulago trifida Boiss., an endemic species to Iran.

    PubMed

    Tavakoli, Saeed; Delnavazi, Mohammad-Reza; Hadjiaghaee, Reza; Jafari-Nodooshan, Saeedeh; Khalighi-Sigaroodi, Farahnaz; Akhbari, Maryam; Hadjiakhoondi, Abbas; Yassa, Narguess

    2017-09-27

    Phytochemical analysis of the Ferulago trifida Boiss. from Apiaceae family led to the isolation and identification of suberosin (1), isoimperatorin (2), prantschimgin (3), oxypeucedanin (4), oxypeucedanin methanolate (5), suberenol (6), 6-hydroxymethylherniarin (7), oxypeucedanin hydrate (8), ulopterol (9), bergapten (10), xanthotoxin (11), imperatorin (12) and grandivittin (13) from chloroform extracts of the roots (1-9) and fruits (1, 2, 8, 10-13) of this species. Oxypeucedanin methanolate and suberenol demonstrated a potent antioxidant power with 268.2 ± 5.4 and 251.2 ± 6.2 mmol FSE/100 g, respectively, compared by BHT (267.2 ± 4.2 mmol FSE/100 g) in FRAP method. The potent antibacterial effects were found for oxypeucedanin methanolate on S. epidermidis (IZ; 26 mm, MIC; 250 μg mL(-1)) an oxypeucedanin hydrate on K. pneumoniae (IZ: 21 mm, MIC: 250 μg mL(-1)). Moreover, suberosin showed higher preferential toxicity against MDA-MB-23 cells (IC50: 0.21 mM, SI: 5.0), in comparison with tamoxifen (IC50: 0.012 mM, SI: 2.45) in MTT assay.

  18. Origin of the allochthons in the Lycien belt, Southwest Turkey

    NASA Astrophysics Data System (ADS)

    Özkaya, İsmail

    1990-06-01

    The Lycien belt of Southwest Turkey lies between the Menderes metamorphic massif to the northwest and the Bey Daǧlari carbonate platform to the southeast. The belt is characterized by thrust faults, melanges and peridotites. Stratigraphic and structural relationships suggest that the allochthons of the Lycien belt were derived from two distinct tectonic terrains. The Köyceǧiz and Elmali thrust slices were from south of the massif; the Tefenni nappe originated far north of the Menderes massif. The latter incorporates platform sediments; melanges and ophiolites represent the edge of a continental platform opening into the Tethys oceanic realm. Correlation of the Elmali and Köyceǧiz thrust slices and autochthonous tectonic elements shows that the Lycien belt between the Menderes massif and the Bey Daǧlari was a tectonically active zone of weakness. The belt, which may be at the extension of the Ionian zone, was subjected to repeated cycles of deep basin subsidence and intense deformation in Triassic, Jurassic-Early Cretaceous and Tertiary times. The Tefenni nappe passed over the Menderes massif and emplaced onto the Lycien terrain in the Late Eocene. The Lycien terrain was subsequently fragmented and overthrusted southeastward onto the Bey Daǧlari shelf sediments in Late Miocene time.

  19. Tailoring the optimal control cost function to a desired output: application to minimizing phase errors in short broadband excitation pulses

    NASA Astrophysics Data System (ADS)

    Skinner, Thomas E.; Reiss, Timo O.; Luy, Burkhard; Khaneja, Navin; Glaser, Steffen J.

    2005-01-01

    The de facto standard cost function has been used heretofore to characterize the performance of pulses designed using optimal control theory. The freedom to choose new, creative quality factors designed for specific purposes is demonstrated. While the methodology has more general applicability, its utility is illustrated by comparison to a consistently chosen example—broadband excitation. The resulting pulses are limited to the same maximum RF amplitude used previously and tolerate the same variation in RF homogeneity deemed relevant for standard high-resolution NMR probes. Design criteria are unchanged: transformation of Iz → Ix over resonance offsets of ±20 kHz and RF variability of ±5%, with a peak RF amplitude equal to 17.5 kHz. However, the new cost effectively trades a small increase in residual z magnetization for improved phase in the transverse plane. Compared to previous broadband excitation by optimized pulses (BEBOP), significantly shorter pulses are achievable, with only marginally reduced performance. Simulations transform Iz to greater than 0.98 Ix, with phase deviations of the final magnetization less than 2°, over the targeted ranges of resonance offset and RF variability. Experimental performance is in excellent agreement with the simulations.

  20. Dollar Summary of Prime Contract Awards over $25,000 by State, Place, and Contractor. Part 1 (Alabama - Idaho), FY1991

    DTIC Science & Technology

    1991-01-01

    al m r N l -4 101 1- 0 IJ..I -4 00 - 4 -( Z IL Il 1-C" ( z 0a 0 Oz CD wzzI- 0 Z . CIE ~ ~ > zul .4 00 z w1’.r c.4< 0 0 "O- I- 41O w~ (0ll w u 1-1o 0 0-0...Il- ZUL - 0". I CL 4- cc. N- CD 0 a"N IA i- 000 Ii: <IZ 00 " 0 0) - - Z w CO 7" 0-=-<< ’.-W ZIw IL(- W.4 W4< O WW W(0 EUL.L.L" -Q C O Q I-- QI) w c j U...C Z) I U*j 0 < ix I In 1.- 3( Ii <- )1 30 >- I 0 1 D Q0 in3x0" O- I) I hAz L) 0 O w 1. In Iu0Z <L r L zo x I-~ w I-a ZQ3O =) (n Cd fI Iz I xI z ow- V

  1. An Algorithm for 353 Odor Detection Thresholds in Humans

    PubMed Central

    Sánchez-Moreno, Ricardo; Cometto-Muñiz, J. Enrique; Cain, William S.

    2012-01-01

    One hundred and ninety three odor detection thresholds, ODTs, obtained by Nagata using the Japanese triangular bag method can be correlated as log (1/ODT) by a linear equation with R2 = 0.748 and a standard deviation, SD, of 0.830 log units; the latter may be compared with our estimate of 0.66 log units for the self-consistency of Nagata's data. Aldehydes, acids, unsaturated esters, and mercaptans were included in the equation through indicator variables that took into account the higher potency of these compounds. The ODTs obtained by Cometto-Muñiz and Cain, by Cometto-Muñiz and Abraham, and by Hellman and Small could be put on the same scale as those of Nagata to yield a linear equation for 353 ODTs with R2 = 0.759 and SD = 0.819 log units. The compound descriptors are available for several thousand compounds, and can be calculated from structure, so that further ODT values on the Nagata scale can be predicted for a host of volatile or semivolatile compounds. PMID:21976369

  2. Antimicrobial and anti-Quorum Sensing activities of selected medicinal plants of Ethiopia: Implication for development of potent antimicrobial agents.

    PubMed

    Bacha, Ketema; Tariku, Yinebeb; Gebreyesus, Fisseha; Zerihun, Shibru; Mohammed, Ali; Weiland-Bräuer, Nancy; Schmitz, Ruth A; Mulat, Mulugeta

    2016-07-11

    Traditional medicinal plants have been used as an alternative medicine in many parts of the world, including Ethiopia. There are many documented scientific reports on antimicrobial activities of the same. To our knowledge, however, there is no report on the anti-Quorum Sensing (Quorum Quenching, QQ) potential of traditional Ethiopian medicinal plants. As many of the opportunistic pathogenic bacteria depend on Quorum Sensing (QS) systems to coordinate their virulence expression, interference with QS could be a novel approach to control bacterial infections. Thus, the aim of this study was to evaluate selected medicinal plants from Ethiopia for their antimicrobial activities against bacterial and fungal pathogens; and to assess the interference of these plant extracts with QS of bacteria. Antimicrobial activities of plant extracts (oil, resins and crude extracts) were evaluated following standard agar diffusion technique. The minimum inhibitory concentrations (MIC) of potent extracts were determined using 96 well micro-titer plates and optical densities were measured using an ELISA Microplate reader. Interference with Quorum Sensing activities of extracts was determined using the recently established E. coli based reporter strain AI1-QQ.1 and signaling molecule N-(ß-ketocaproyl)-L-homoserine lactone (3-oxo-C6-HSL). Petroleum ether extract of seed of Nigella sativa exhibited the highest activity against both the laboratory isolated Bacillus cereus [inhibition zone (IZ), 44 ± 0.31 mm] and B. cereus ATCC 10987 (IZ, 40 ± 2.33 mm). Similarly, oil extract from mature ripe fruit husk of Aframomum corrorima and mature unripe fruit of A. corrorima revealed promising activities against Candida albicans ATCC 90028 (IZ, 35 ± 1.52 mm) and Staphylococcus aureus DSM 346 (IZ, 25 ± 1.32 mm), respectively. Antimicrobial activities of oil extract from husk of A. corrorima and petroleum ether extract of seed of N. sativa were significantly higher than that of

  3. Classification of EEG abnormalities in partial epilepsy with simultaneous EEG-fMRI recordings.

    PubMed

    Pedreira, C; Vaudano, A E; Thornton, R C; Chaudhary, U J; Vulliemoz, S; Laufs, H; Rodionov, R; Carmichael, D W; Lhatoo, S D; Guye, M; Quian Quiroga, R; Lemieux, L

    2014-10-01

    Scalp EEG recordings and the classification of interictal epileptiform discharges (IED) in patients with epilepsy provide valuable information about the epileptogenic network, particularly by defining the boundaries of the "irritative zone" (IZ), and hence are helpful during pre-surgical evaluation of patients with severe refractory epilepsies. The current detection and classification of epileptiform signals essentially rely on expert observers. This is a very time-consuming procedure, which also leads to inter-observer variability. Here, we propose a novel approach to automatically classify epileptic activity and show how this method provides critical and reliable information related to the IZ localization beyond the one provided by previous approaches. We applied Wave_clus, an automatic spike sorting algorithm, for the classification of IED visually identified from pre-surgical simultaneous Electroencephalogram-functional Magnetic Resonance Imagining (EEG-fMRI) recordings in 8 patients affected by refractory partial epilepsy candidate for surgery. For each patient, two fMRI analyses were performed: one based on the visual classification and one based on the algorithmic sorting. This novel approach successfully identified a total of 29 IED classes (compared to 26 for visual identification). The general concordance between methods was good, providing a full match of EEG patterns in 2 cases, additional EEG information in 2 other cases and, in general, covering EEG patterns of the same areas as expert classification in 7 of the 8 cases. Most notably, evaluation of the method with EEG-fMRI data analysis showed hemodynamic maps related to the majority of IED classes representing improved performance than the visual IED classification-based analysis (72% versus 50%). Furthermore, the IED-related BOLD changes revealed by using the algorithm were localized within the presumed IZ for a larger number of IED classes (9) in a greater number of patients than the expert

  4. Dose equations for tube current modulation in CT scanning and the interpretation of the associated CTDI{sub vol}

    SciTech Connect

    Dixon, Robert L.; Boone, John M.

    2013-11-15

    Purpose: The scanner-reported CTDI{sub vol} for automatic tube current modulation (TCM) has a different physical meaning from the traditional CTDI{sub vol} at constant mA, resulting in the dichotomy “CTDI{sub vol} of the first and second kinds” for which a physical interpretation is sought in hopes of establishing some commonality between the two.Methods: Rigorous equations are derived to describe the accumulated dose distributions for TCM. A comparison with formulae for scanner-reported CTDI{sub vol} clearly identifies the source of their differences. Graphical dose simulations are also provided for a variety of TCM tube current distributions (including constant mA), all having the same scanner-reported CTDI{sub vol}.Results: These convolution equations and simulations show that the local dose at z depends only weakly on the local tube current i(z) due to the strong influence of scatter from all other locations along z, and that the “local CTDI{sub vol}(z)” does not represent a local dose but rather only a relative i(z) ≡ mA(z). TCM is a shift-variant technique to which the CTDI-paradigm does not apply and its application to TCM leads to a CTDI{sub vol} of the second kind which lacks relevance.Conclusions: While the traditional CTDI{sub vol} at constant mA conveys useful information (the peak dose at the center of the scan length), CTDI{sub vol} of the second kind conveys no useful information about the associated TCM dose distribution it purportedly represents and its physical interpretation remains elusive. On the other hand, the total energy absorbed E (“integral dose”) as well as its surrogate DLP remain robust between variable i(z) TCM and constant current i{sub 0} techniques, both depending only on the total mAs =t{sub 0}=i{sub 0} t{sub 0} during the beam-on time t{sub 0}.

  5. Synthesis, radioiodination and in vitro and in vivo sigma receptor studies of N-1-allyl-N´-4-phenethylpiperazine analogs.

    PubMed

    Lever, Susan Z; Xu, Rong; Fan, Kuo-Hsien; Fergason-Cantrell, Emily A; Carmack, Terry L; Watkinson, Lisa D; Lever, John R

    2012-04-01

    Sigma-1 (σ(1)) receptor radioligands are useful for basic pharmacology studies and for imaging studies in neurology, psychiatry and oncology. We derived a hybrid structure, N-1-allyl-N´-4-phenethylpiperazine, from known ligands TPCNE and SA4503 for use as a scaffold for development of radioiodinated σ(1) receptor ligands. E-and Z-N-1-(3'-iodoallyl)-N´-4-(3″,4″-dimethoxyphenethyl)-piperazine (E-1 and Z-1), N-1-allyl-N´-4-(3',4'-dimethoxyphenethyl)-piperazine (2) and E-N-1-(3'-iodoallyl)-N´-4-(3″-methoxy-4'´-hydroxyphenethyl)-piperazine (3) were synthesized. Affinities for σ(1) and σ(2) receptors were determined. [(125)I]E-1 and [(125)I]Z-1 were prepared and evaluated in vivo in mice. [(125)I]E-1 was further evaluated in σ(1) receptor binding assays in vitro. E-1 displayed moderately high apparent affinity (15 nM) for σ(1) sites and 84-fold selectivity against σ(2) sites. Z-1 showed similar σ(1) affinity, but only 23-fold selectivity. In contrast, 2 exhibited poor binding to both subtypes, while 3 had good affinities but poor selectivity. E-1 profiled as a probable antagonist in the phenytoin shift assay. [(125)I]E-1 and [(125)I]Z-1 were prepared in good yields and with high specific radioactivities. Log D(7.4) values (2.25 and 2.27) fall within the optimal range for in vivo studies. Both radioligands selectively labeled σ(1) receptors in mouse brain and peripheral organs in vivo. [(125)I]E-1 showed a higher level of specific binding than [(125)I]Z-1 and displayed good metabolic stability. Further, [(125)I]E-1 selectively labeled σ(1) receptors in mouse brain homogenates (K(d) 3.79 nM; B(max)=599 fmol/mg protein). [(125)I]E-1 is a selective σ(1) receptor radioligand that exhibits properties amenable to in vitro and in vivo studies, with possible extension to single photon emission computed tomography using iodine-123. Copyright © 2012. Published by Elsevier Inc.

  6. Mechanism Elucidation of the cis–trans Isomerization of an Azole Ruthenium–Nitrosyl Complex and Its Osmium Counterpart

    PubMed Central

    2013-01-01

    Synthesis and X-ray diffraction structures of cis and trans isomers of ruthenium and osmium metal complexes of general formulas (nBu4N)[cis-MCl4(NO)(Hind)], where M = Ru (1) and Os (3), and (nBu4N)[trans-MCl4(NO)(Hind)], where M = Ru (2) and Os (4) and Hind = 1H-indazole are reported. Interconversion between cis and trans isomers at high temperatures (80–130 °C) has been observed and studied by NMR spectroscopy. Kinetic data indicate that isomerizations correspond to reversible first order reactions. The rates of isomerization reactions even at 110 °C are very low with rate constants of 10–5 s–1 and 10–6 s–1 for ruthenium and osmium complexes, respectively, and the estimated rate constants of isomerization at room temperature are of ca. 10–10 s–1. The activation parameters, which have been obtained from fitting the reaction rates at different temperatures to the Eyring equation for ruthenium [ΔHcis-trans‡= 122.8 ± 1.3; ΔHtrans-cis‡= 138.8 ± 1.0 kJ/mol; ΔScis-trans‡= −18.7 ± 3.6; ΔStrans-cis‡= 31.8 ± 2.7 J/(mol·K)] and osmium [ΔHcis-trans‡= 200.7 ± 0.7; ΔHtrans-cis‡= 168.2 ± 0.6 kJ/mol; ΔScis-trans‡= 142.7 ± 8.9; ΔStrans-cis‡= 85.9 ± 3.9 J/(mol·K)] reflect the inertness of these systems. The entropy of activation for the osmium complexes is highly positive and suggests the dissociative mechanism of isomerization. In the case of ruthenium, the activation entropy for the cis to trans isomerization is negative [−18.6 J/(mol·K)], while being positive [31.0 J/(mol·K)] for the trans to cis conversion. The thermodynamic parameters for cis to trans isomerization of [RuCl4(NO)(Hind)]−, viz. ΔH° = 13.5 ± 1.5 kJ/mol and ΔS° = −5.2 ± 3.4 J/(mol·K) indicate the low difference between the energies of cis and trans isomers. The theoretical calculation has been carried out on isomerization of ruthenium complexes with DFT methods. The dissociative, associative, and intramolecular twist isomerization mechanisms have

  7. Focal point analysis of torsional isomers of acrylic acid

    NASA Astrophysics Data System (ADS)

    Alev Çiftçioğlu, Gökçen; Trindle, Carl; Yavuz, Ilhan

    2010-10-01

    The thermochemistry of acrylic acid has presented challenges owing to its high reactivity, tendency to dimerize in the gas phase, and the existence of two very nearly equal energy conformational isomers. Well-tested thermochemical schemes including G2, G3, G4, and CBS-QB3 agree in the prediction that the s-cis syn structure is the most stable of the torsional isomers, with the s-cis anti form lying 3 kJ mol-1 or less higher in energy. Microwave spectra suggest a value of 0.63 kJ mol-1. The energy barrier between these forms is in the neighbourhood of 25 kJ mol-1 according to a MP2/cc-pVDZ calculation. We present estimates of the relative energies of all four torsional isomers and the rotational barrier based on a variant of the Focal Point Analysis developed by Császár and co-workers. These calculations, extending to the CCSD(T)/cc-pV5Z level, predict that the s-cis anti torsional isomer is the most stable form, in contrast to prior estimates. The s-cis syn form lies about 2.9 kJ mol-1 higher, while the s-trans syn and anti forms lie at about 21.7 and 23.3 kJ mol-1, respectively. We estimate the rotational barrier between the s-cis trans and s-cis anti structures to be about 23.9 kJ mol-1. Error ranges derived from the fit to extrapolation forms suggest that our estimates have an uncertainty of about 0.1 kJ mol-1.

  8. Heat capacity measurements for cryolite (Na3AlF6) and reactions in the system NaFeAlSiOF

    USGS Publications Warehouse

    Anovitz, Lawrence M.; Hemingway, B.S.; Westrum, E.F.; Metz, G.W.; Essene, E.J.

    1987-01-01

    The heat capacity of cryolite (Na3AlF6) has been measured from 7 to 1000 K by low-temperature adiabatic and high-temperature differential scanning calorimetry. Low-temperature data were obtained on material from the same hand specimen in the calorimetric laboratories of the University of Michigan and U.S. Geological Survey. The results obtained are in good agreement, and yield average values for the entropy of cryolite of: S0298 = 238.5 J/mol KS0T-S0298 = 145.114 ln T+ 193.009*10-3T- 10.366* 105 T2- 872.89 J/mol K (273-836.5 K)??STrans = 9.9J/mol KS0T-S0298 =198.414 ln T+73.203* 10-3T-63.814* 105 T2-1113.11 J/mol K (836.5-1153 K) with the transition temperature between ??- and ??-cryolite taken at 836.5 K. These data have been combined with data in the literature to calculate phase equilibria for the system NaFeAlSiOF. The resultant phase diagrams allow constraints to be placed on the fO2, fF2, aSiO2 and T conditions of formation for assemblages in alkalic rocks. A sample application suggests that log fO2 is approximately -19.2, log fF2 is -31.9 to -33.2, and aSiO2 is -1.06 at assumed P T conditions of 1000 K, 1 bar for the villiaumite-bearing Ilimaussaq intrusion in southwestern Greenland. ?? 1987.

  9. Biaxial ordering of terminal diene groups in lipid membranes: an infrared linear dichroism study

    NASA Astrophysics Data System (ADS)

    Binder, H.; Gutberlet, T.; Anikin, A.

    1999-11-01

    The molecular order within the hydrophobic core of membranes of the diene lipid di-tetradecadienoylphosphatidylcholine was studied by means of infrared spectroscopy on multibilayer assemblies which orient macroscopically on the surface of an attenuated total reflection crystal. The relative humidity and temperature were used as variable parameters to demonstrate that there were profound differences in the melting transition of lipids possessing predominantly cis and trans diene groups. The cis isomer undergoes the phase transition at a vapor pressure which is increased by ∽0.15 GPa when compared with that of the trans isomer. The methylene wagging band progression gives no indication of differences between the acyl chain conformation of the cis and trans forms in the gel state. The frequencies of a number of absorption bands of the diene groups reveal that these moieties are predominantly in the s-trans conformation to accommodate a favorable packing within the bilayer. The linear dichroism of selected in-plane and out-of-plane vibrations of the diene groups gives indications of the biaxial ordering of these moieties. We present the basic equations for the quantitative analysis of IR dichroism data of lamellar structures in terms of transverse and longitudinal molecular order parameters. It turns out that the planes of the rigid diene groups orient preferentially in a perpendicular direction with respect to the bilayer surface and parallel to each other forming in this way a layer of well-aligned diene groups in the bilayer center. This finding is confirmed by the results of X-ray measurements. We suggest that the partial interdigitation of the diene groups of the sn-1 acyl chains promotes the formation of the inverse H II phase and/or enables the formation of covalent bonds between both the monolayers upon polymerization of diene lipids.

  10. Leukotriene A4 hydrolase: Selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375

    PubMed Central

    Rudberg, Peter C.; Tholander, Fredrik; Thunnissen, Marjolein M. G. M.; Samuelsson, Bengt; Haeggström, Jesper Z.

    2002-01-01

    Leukotriene A4 (LTA4, 5S-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid) hydrolase (LTA4H)/aminopeptidase is a bifunctional zinc metalloenzyme that catalyzes the final and rate-limiting step in the biosynthesis of leukotriene B4 (LTB4, 5S,12R-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid), a classical chemoattractant and immune modulating lipid mediator. Two chemical features are key to the bioactivity of LTB4, namely, the chirality of the 12R-hydroxyl group and the cis-trans-trans geometry of the conjugated triene structure. From the crystal structure of LTA4H, a hydrophilic patch composed of Gln-134, Tyr-267, and Asp-375 was identified in a narrow and otherwise hydrophobic pocket, believed to bind LTA4. In addition, Asp-375 belongs to peptide K21, a previously characterized 21-residue active site-peptide to which LTA4 binds during suicide inactivation. In the present report we used site-directed mutagenesis and x-ray crystallography to show that Asp-375, but none of the other candidate residues, is specifically required for the epoxide hydrolase activity of LTA4H. Thus, mutation of Asp-375 leads to a selective loss of the enzyme's ability to generate LTB4 whereas the aminopeptidase activity is preserved. We propose that Asp-375, possibly assisted by Gln-134, acts as a critical determinant for the stereoselective introduction of the 12R-hydroxyl group and thus the biological activity of LTB4. PMID:11917124

  11. Putative sigma(3) sites in mammalian brain have histamine H(1) receptor properties: evidence from ligand binding and distribution studies with the novel H(1) radioligand [(3)H]-(-)-trans-1-phenyl-3-aminotetralin.

    PubMed

    Booth, R G; Owens, C E; Brown, R L; Bucholtz, E C; Lawler, C P; Wyrick, S D

    1999-08-07

    A novel phenylaminotetralin (PAT) radioligand, [(3)H]-(1R, 3S)-(-)-trans-1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene ([(3)H]-[-]-trans-H(2)-PAT), is shown here to label a saturable (B(max)=39+/-6 fmol/mg protein) population of sites with high affinity (K(d)=0.13+/-0.03 nM) in guinea pig brain. Consistent with previous studies which showed that PATs stimulate catecholamine (dopamine) synthesis in rat striatum, autoradiographic brain receptor mapping studies here indicate that [(3)H]-(-)-trans-H(2)-PAT-labeled sites are highly localized in catecholaminergic nerve terminal fields in hippocampus, nucleus accumbens, and striatum in guinea pig brain. Competition binding studies with a broad range of CNS receptor-active ligands and CNS radioreceptor screening assays indicate that the pharmacological binding profile of brain [(3)H]-(-)-trans-H(2)-PAT sites closely resembles histamine H(1)-type receptors. Comparative studies using the histamine H(1) antagonist radioligand, [(3)H]mepyramine, indicate that the H(1) ligand binding profile and guinea pig brain distribution of H(1) receptors and [(3)H]-(-)-trans-H(2)-PAT sites are nearly identical; moreover, both sites have about 40-fold stereoselective affinity for (-)- over (+)-trans-H(2)-PAT. These results are discussed in light of previous studies which suggested that PATs stimulate dopamine synthesis through interaction with a novel sigma-type (sigma(3)) receptor in rodent brain; it now appears instead that PATs represent a new class of ligands for brain histamine H(1) receptors that can be stereoselectively labeled with [(3)H]-(-)-trans-H(2)-PAT. Copyright 1999 Published by Elsevier Science B.V.

  12. Methylparaben isolated in solid argon: structural characterization and UV-induced conversion into methylparaben radical and isomeric ketenes.

    PubMed

    Kuş, Nihal; Bayarı, Sevgi H; Fausto, Rui

    2013-10-31

    Methylparaben (methyl p-hydroxybenzoic acid; MP) is a widely used antimicrobial preservative, being the most frequently used antimicrobial preservative in cosmetics. The generalized use of MP has become controversial, with several recent reports of dangerous side effects. For example, the presence of MP in human breast tumors and its harmful effects on human skin exposed to the sunlight have been demonstrated. In spite of the important practical relevance of the compound and of the controversy about its practical use, its structural and photochemical characterization had not been undertaken hitherto. To fill this gap, in the present study, MP was isolated in solid argon (T = 15 K) and structurally characterized by a combined infrared spectroscopy/quantum chemistry approach. The potential energy surface (PES) of the molecule was investigated in detail, revealing the existence of two almost isoenergetic (ΔE(0) = 0.37 kJ mol(-1)) s-cis carboxylic ester low-energy conformers, with an estimated population ratio in the gas phase at room temperature (∼298 K) of ca. 0.83. The calculations also predicted the existence of two high-energy (ΔE(0) = ∼50 kJ mol(-1)) s-trans carboxylic ester conformers of MP. Upon isolation of the compound in an argon matrix, only the lowest energy conformer was found to survive, due to occurrence of extensive conformational cooling during matrix deposition. The infrared spectrum of this conformer was obtained and interpreted. In addition, the chemical processes resulting from in situ irradiation of the matrix-isolated MP with a broadband UV source (λ > 234 nm) were investigated, revealing extensive conversion of MP into highly reactive methylparaben radical and isomeric ketenes. These observations support the recent concerns regarding uses of MP, in particular when the compound has to be exposed to UV light.

  13. PEG-Farnesylthiosalicylate Conjugate as a Nanomicellar Carrier for Delivery of Paclitaxel

    PubMed Central

    Zhang, Xiaolan; Lu, Jianqin; Huang, Yixian; Zhao, Wenchen; Li, Jiang; Gao, Xiang; Venkataramanan, Raman; Sun, Min; Stolz, Donna D.; Zhang, Lin; Li, Song

    2013-01-01

    S-trans, trans-farnesylthiosalicylic acid (FTS) is a synthetic small molecule that acts as a potent and especially nontoxic Ras antagonist. It inhibits both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth. In this work, a FTS conjugate with polyethylene glycol (PEG) through a labile ester linkage, PEG5K-FTS2(L), was developed. PEG5K-FTS2 conjugate readily forms micelles in aqueous solutions with a critical micelle concentration of 0.68 μM and hydrophobic drugs such as paclitaxel (PTX) could be effectively loaded into these particles. Both drug-free and PTX- loaded micelles were spherical in shape with a uniform size of 20 ~ 30 nm. The release of PTX from PTX-loaded PEG5K-FTS2 micelles was significantly slower than that from Taxol formulation. In vitro cytotoxicity studies with several tumor cell lines showed that PEG5K-FTS2(L) was comparable to FTS in antitumor activity. Western immunoblotting showed that total Ras levels were downregulated in several cancer cell lines treated with FTS or PEG5K-FTS2(L). The micellar formulation of PTX exhibited more in vitro cytotoxic activity against several tumor cell lines compared with free PTX, suggesting a possible synergistic effect between the carrier and the codelivered drug. The anti-tumor activity of the PTX loaded PEG5K-FTS2(L) micelles in a syngeneic murine breast cancer model was found to be significantly higher than that of Taxol, which may be attributed to their preferential tumor accumulation and a possible synergistic effect between PEG5K-FTS2 carrier and loaded PTX. PMID:23425093

  14. Design of a helix-bundle cross-link: NMR and UV-visible spectroscopic analyses and molecular modeling of ring-oxidized retinals

    SciTech Connect

    Williams, T.C.; Mani, V. M and S Data Analysis and Molecular Speculations, Charleston, SC )

    1991-03-19

    In order to generate potential chemical cross-links for studying the chromophore binding site of bacteriorhodopsin and related helix-bundle proteins, MnO{sub 2} was used to oxidize all-trans-retinal's ring moiety. The structures and solution conformations of three ring-oxidized retinal analogues have been determined by using UV-visible absorption and {sup 1}H and {sup 13}C NMR spectroscopies, primarily with regard to (i) the introduction of a functional group at the ring end of the chromophore, (ii) the retention of the all-trans geometry of the polyenal side chain, and (iii) the torsional angle of the ring-polyenal bond. Analyses of their UV-visible absorption spectral parameters and NMR spectral parameters indicated the 4-oxo and the 2,3-dehydro-4-oxo derivatives both possess the twisted 6-2-cis conformation adopted by most six-membered ring analogues of retinal in solution or crystal. Because the chromophores of bacterio-and halorhodopsins and sensory rhodopsins are bound as the 6-s-trans conformer the authors suggest that the cyclopentenyl analogue's {alpha}-diketo function may be favorably positioned within the binding pocket and sufficiently reactive toward nucleophilic attack to cross-link an arginine located in or near the ring end of the chromophore cavity: Arg{sup 134} according to the current model of bacteriorhodopsin's tertiary structure of Arg{sup 82} as postulated from an alternate model constructed primarily to accommodate the external point charge contribution to bacteriorhodopsins's opsin shift.

  15. The Millimeter-Wave Spectrum of Methacrolein. Torsion-Rotation Effects in the Excited States

    NASA Astrophysics Data System (ADS)

    Zakharenko, Olena; Motiyenko, R. A.; Aviles Moreno, Juan-Ramon; Huet, T. R.

    2015-06-01

    Last year we reported the analysis of the rotational spectrum of s-trans conformer of methacrolein CH2=C(CH3)CHO in the ground vibrational state. In this talk we report the study of its low lying excited vibrational states. The study is based on room-temperature absorption spectra of methacrolein recorded in the frequency range 150 - 465 GHz using the spectrometer in Lille. The new results include assignment of the first excited torsional state (131 cm-1), and the joint analysis of the vt = 0 and vt = 1 states, that allowed us to improve the model in the frame of Rho-Axis-Method (RAM) Hamiltonian and to remove some strong correlations between parameters. Also we assigned the first excited vibrational state of the skeletal torsion mode (170 cm-1). The inverse sequence of A and E tunneling substates as well as anomalous A-E splittings observed for the rotational lines of vsk = 1 state clearly indicate a coupling between methyl torsion and skeletal torsion. However we were able to fit within experimental accuracy the rotational lines of vsk = 1 state using the RAM Hamiltonian. Because of the inversion of the A and E tunneling substates the rotational lines of the vsk = 1 states were assumed to belong to a virtual first excited torsional state. Finally, we assigned several low-Ka rotational transitions of the excited vibrational states above 200 cm-1 but their analysis is complicated by different rotation-vibration interactions. In particular there is an evidence of the Fermi-type resonance between the second excited torsional state and the first excited state of the in-plane skeletal bending mode (265 cm-1). Support from the French Laboratoire d'Excellence CaPPA (Chemical and Physical Properties of the Atmosphere) through contract ANR-10-LABX-0005 of the Programme d'Investissements d'Avenir is acknowledged. Zakharenko O. et al., 69th ISMS, 2014, TI01

  16. Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site.

    PubMed

    Brown, Kyle L; Roginskaya, Marina; Zou, Yue; Altamirano, Alvin; Basu, Ashis K; Stone, Michael P

    2010-01-01

    The 5R thymine glycol (5R-Tg) DNA lesion exists as a mixture of cis-(5R,6S) and trans-(5R,6R) epimers; these modulate base excision repair. We examine the 7:3 cis-(5R,6S):trans-(5R,6R) mixture of epimers paired opposite adenine in the 5'-GTgG-3' sequence with regard to nucleotide excision repair. Human XPA recognizes the lesion comparably to the C8-dG acetylaminoflourene (AAF) adduct, whereas XPC/HR23B recognition of Tg is superior. 5R-Tg is processed by the Escherichia coli UvrA and UvrABC proteins less efficiently than the C8-dG AAF adduct. For the cis-(5R, 6S) epimer Tg and A are inserted into the helix, remaining in the Watson-Crick alignment. The Tg N3H imine and A N(6) amine protons undergo increased solvent exchange. Stacking between Tg and the 3'-neighbor G*C base pair is disrupted. The solvent accessible surface and T(2) relaxation of Tg increases. Molecular dynamics calculations predict that the axial conformation of the Tg CH(3) group is favored; propeller twisting of the Tg*A pair and hydrogen bonding between Tg OH6 and the N7 atom of the 3'-neighbor guanine alleviate steric clash with the 5'-neighbor base pair. Tg also destabilizes the 5'-neighbor G*C base pair. This may facilitate flipping both base pairs from the helix, enabling XPC/HR23B recognition prior to recruitment of XPA.

  17. Ab initio study of phosphaalkenes

    SciTech Connect

    Liu, M.

    1992-01-01

    This dissertation presents the application of computational chemistry to investigate a new class of organic compound-phosphaalkenes. The history of room temperature stable phosphaalkenes is a matter of the last 20 years. The existence of the C[double bond]P [pi] bond has challenged the concept that the 2p-3p [pi] bond is supposed to be very unstable and weak. Theoretical study of this type of compound can clear up the unknown properties, reactivities and reaction mechanisms of phosphaalkenes. The aim of this research is to theoretically determine the electronic and molecular properties, the chemical properties, and predict synthetic candidates for this family. Employing ab initio quantum chemistry, the authors have completed 7 related projects. First, the authors examined the reaction mechanism in the general synthesis of 1,3-diphosphallene and located the step that controls the stereo-outcome of the final product. Second, the authors predicted 4-phosphamethylenecylopropene to be a stable compound, which has been successfully synthesized after this research appeared. Third, the rotational energy surface of the rotation from s-trans to s-cis for mon- and di-phospha-1,3-butadienes were examined and concluded that the rotation does not have a high barrier. Fourth, fifth, and sixth, the authors continued their interest in phospha-1,3-butadienes and investigated [2+2] and Diels-Alder reactions. The energetics and stereo consequences of these reactions have been explored in this research. Finally, they also systematically studied the bonding properties of phosphacumulenes and provided some structural insight for this unsettled area.

  18. Monocyte-to-Macrophage Differentiation

    PubMed Central

    Chang, Mary Y.; Chan, Christina K.; Braun, Kathleen R.; Green, Pattie S.; O'Brien, Kevin D.; Chait, Alan; Day, Anthony J.; Wight, Thomas N.

    2012-01-01

    Although monocyte- and macrophage-derived molecules are known to promote extracellular matrix (ECM) disruption and destabilization, it is less appreciated that they also synthesize molecules contributing to ECM formation, stabilization, and function. We have identified and characterized the synthesis of proteoglycans and related proteins, some not previously known to be associated with macrophages. Proteoglycan extracts of [35S]sulfate- and 35S-trans amino acid-radiolabeled culture media from THP-1 monocytes induced to differentiate by treatment with phorbol myristate acetate revealed three major proteins of ∼25, 90, and 100 kDa following chondroitin ABC lyase digestion. The 25-kDa protein was predominant for monocytes, whereas the 90- and 100-kDa proteins were predominant for macrophages. Tandem mass spectrometry identified (i) the 25-kDa core protein as serglycin, (ii) the 90-kDa core protein as inter-α-inhibitor heavy chain 2 (IαIHC2), and (iii) the 100-kDa core as amyloid precursor-like protein 2 (APLP2). Differentiation was also associated with (i) a >500-fold increase in mRNA for TNF-stimulated gene-6, an essential cofactor for heavy chain-mediated matrix stabilization; (ii) a >800-fold increase in mRNA for HAS2, which is responsible for hyaluronan synthesis; and (iii) a 3-fold increase in mRNA for versican, which interacts with hyaluronan. Biochemical evidence is also presented for an IαIHC2-APLP2 complex, and immunohistochemical staining of human atherosclerotic lesions demonstrates similar staining patterns for APLP2 and IαIHC2 with macrophages, whereas serglycin localizes to the underlying glycosaminoglycan-rich region. These findings indicate that macrophages synthesize many of the molecules participating in ECM formation and function, suggesting a novel role for these molecules in the differentiation of macrophages in the development of atherosclerosis. PMID:22351750

  19. Solvent Effects on the Absorption Spectra of the para-Coumaric Acid Chromophore in Its Different Protonation Forms.

    PubMed

    García-Prieto, Francisco F; Galván, Ignacio Fdez; Muñoz-Losa, Aurora; Aguilar, Manuel A; Martín, M Elena

    2013-10-08

    The effects of the solvent and protonation state on the electronic absorption spectrum of the para-coumaric acid (pCA), a model of the photoactive yellow protein (PYP), have been studied using the ASEP/MD (averaged solvent electrostatic potential from molecular dynamics) method. Even though, in the protein, the chromophore is assumed to be in its phenolate monoanionic form, when it is found in water solution pH control can favor neutral, monoanionic, and dianionic species. As the pCA has two hydrogens susceptible of deprotonation, both carboxylate and phenolate monoanions are possible. Their relative stabilities are strongly dependent on the medium. In gas phase, the most stable isomer is the phenolate while in aqueous solution it is the carboxylate, although the population of the phenolate form is not negligible. The s-cis, s-trans, syn, and anti conformers have also been included in the study. Electronic excited states of the chromophore have been characterized by SA-CAS(14,12)-PT2/cc-pVDZ level of theory. The bright state corresponds, in all the cases, to a π → π* transition involving a charge displacement in the system. The magnitude and direction of this displacement depends on the protonation state and on the environment (gas phase or solution). In the same way, the calculated solvatochromic shift of the absorption maximum depends on the studied form, being a red shift for the neutral, carboxylate monoanion, and dianionic chromophores and a blue shift for the phenolate monoanion. Finally, the contribution that the solvent electronic polarizability has on the solvent shift was analyzed. It represents a very important part of the total solvent shift in the neutral form, but its contribution is completly negligible in the mono- and dianionic forms.

  20. Density functional theory and RRKM calculations of decompositions of the metastable E-2,4-pentadienal molecular ions.

    PubMed

    Solano Espinoza, Eduardo A; Vallejo Narváez, Wilmer E

    2010-07-01

    The potential energy profiles for the fragmentations that lead to [C(5)H(5)O](+) and [C(4)H(6)](+*) ions from the molecular ions [C(5)H(6)O](+*) of E-2,4-pentadienal were obtained from calculations at the UB3LYP/6-311G + + (3df,3pd)//UB3LYP/6-31G(d,p) level of theory. Kinetic barriers and harmonic frequencies obtained by the density functional method were then employed in Rice-Ramsperger-Kassel-Marcus calculations of individual rate coefficients for a large number of reaction steps. The pre-equilibrium and rate-controlling step approximations were applied to different regions of the complex potential energy surface, allowing the overall rate of decomposition to be calculated and discriminated between three rival pathways: C-H bond cleavage, decarbonylation and cyclization. These processes should have to compete for an equilibrated mixture of four conformers of the E-2,4-pentadienal ions. The direct dissociation, however, can only become important in the high-energy regime. In contrast, loss of CO and cyclization are observable processes in the metastable kinetic window. The former involves a slow 1,2-hydrogen shift from the carbonyl group that is immediately followed by the formation of an ion-neutral complex which, in turn, decomposes rapidly to the s-trans-1,3-butadiene ion [C(4)H(6)](+*). The predominating metastable channel is the second one, that is, a multi-step ring closure which starts with a rate-limiting cis-trans isomerization. This process yields a mixture of interconverting pyran ions that dissociates to the pyrylium ions [C(5)H(5)O](+). These results can be used to rationalize the CID mass spectrum of E-2,4-pentadienal in a low-energy regime. 2010 John Wiley & Sons, Ltd.

  1. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops.

    PubMed Central

    Rife, J P; Cheng, C S; Moore, P B; Strobel, S A

    1998-01-01

    Modified nucleotides are resource-intensive alternatives to the four nucleotides that constitute the bulk of natural RNAs. Yet, even in cases where modifications are highly conserved, their functions are difficult to identify. One possible function might be to modulate the stability of RNA structures. To investigate this possibility for N 2-methylguanosine (m2G), which is present in a wide variety of RNAs, we have determined the thermodynamic consequences of substituting m2G for G in G-C Watson-Crick pairs and G@U wobble pairs within RNA duplexes. The m2G substitution is iso-energetic with G in all cases, except for aninternal m2G@U pair, where it has a modest (0.3 kcal/mol) stabilizing effect. We have also examined theconsequences of replacing G by m2G, and A by N 6, N 6-dimethyladenosine (m26A) in the helix 45 tetraloop of 16S rRNA, which would otherwise be a standard GNRA tetraloop. This loop is a conserved, hypermethylated region of the ribosome where methylation appears to modulate activity. m26A substitution destabilizes the tetraloop, presumably because it prevents the formation of the G@A sheared pair it would otherwise contain. m2G substitution has no effect on tetraloop stability. Together, these results suggest that m2G is equally stable as either the s-cis or s-trans rotamer. The lack of a significant effect on secondary structural stability in these systems suggests that m2G is introduced into naturally occurring RNAs for reasons other than modulation of duplex stability. PMID:9685477

  2. Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix.

    PubMed

    Chang, Mary Y; Chan, Christina K; Braun, Kathleen R; Green, Pattie S; O'Brien, Kevin D; Chait, Alan; Day, Anthony J; Wight, Thomas N

    2012-04-20

    Although monocyte- and macrophage-derived molecules are known to promote extracellular matrix (ECM) disruption and destabilization, it is less appreciated that they also synthesize molecules contributing to ECM formation, stabilization, and function. We have identified and characterized the synthesis of proteoglycans and related proteins, some not previously known to be associated with macrophages. Proteoglycan extracts of [(35)S]sulfate- and (35)S-trans amino acid-radiolabeled culture media from THP-1 monocytes induced to differentiate by treatment with phorbol myristate acetate revealed three major proteins of ~25, 90, and 100 kDa following chondroitin ABC lyase digestion. The 25-kDa protein was predominant for monocytes, whereas the 90- and 100-kDa proteins were predominant for macrophages. Tandem mass spectrometry identified (i) the 25-kDa core protein as serglycin, (ii) the 90-kDa core protein as inter-α-inhibitor heavy chain 2 (IαIHC2), and (iii) the 100-kDa core as amyloid precursor-like protein 2 (APLP2). Differentiation was also associated with (i) a >500-fold increase in mRNA for TNF-stimulated gene-6, an essential cofactor for heavy chain-mediated matrix stabilization; (ii) a >800-fold increase in mRNA for HAS2, which is responsible for hyaluronan synthesis; and (iii) a 3-fold increase in mRNA for versican, which interacts with hyaluronan. Biochemical evidence is also presented for an IαIHC2-APLP2 complex, and immunohistochemical staining of human atherosclerotic lesions demonstrates similar staining patterns for APLP2 and IαIHC2 with macrophages, whereas serglycin localizes to the underlying glycosaminoglycan-rich region. These findings indicate that macrophages synthesize many of the molecules participating in ECM formation and function, suggesting a novel role for these molecules in the differentiation of macrophages in the development of atherosclerosis.

  3. Color-density relation in the LOW Z sample of the SDSS DR10

    NASA Astrophysics Data System (ADS)

    Deng, X. F.

    2015-04-01

    The aim of this study is to examine the environmental dependence of the u-r, u-g, g-r, r-i and i-z colors in the loz z sample of the Sloan Digital Sky Survey Data Release 10 (SDSS DR10). To decrease the radial selection effect, I divide the low z sample into subsamples with a redshift binning size of Δz=0.01 and analyze the environmental dependence of colors for these subsamples in each redshift bin. The statistical results show that all five colors of galaxies in the low z sample are weakly correlated with the local environment, which is consistent with the results of main galaxies at z>0.15 and CMASS galaxies.

  4. Development of a Computer Emission Inventory Routine for Aircraft Ground Support Equipment. Volume II. Appendices.

    DTIC Science & Technology

    1981-09-30

    MA 0 CC X AWAA Aws AC VI S M C. A A ZZ 17WC c-uuti 0 Goo*6V* *6664*** NL aal 0 4NT 4wI usuu HL V4 OCNUVIw v 4 %AWOi& Z S1CUESSSSZUW U 18 K.~C cu .d 0i...I 25 0*M*(U* *0* *. m.4 . 4*4 .4 c*V0*Q**rI * * ** * Z 0.L)C w i T- vi Iz I 26 QM V )) cu CC U ox 0 oc dw CC % U 4I V) V) V Ii. ML~27 OD * D *D D * D...G IIc IX XvEEEEI- Z 29 m D D(9c Iwwo MsM4Aseesr4 essnc lu C =0 L I- U. H v4 v4 A4OJ vit 03 ( * * * * *e* *D * *N* * * IL1) W * ** OD* E( ata C S N

  5. Rip Channels, Megacusps, and Shoreline Change: Measurements and Modeling

    DTIC Science & Technology

    2010-06-01

    viewability. Top panel izΔ : hCu i j⋅ + ⋅ hCv . Second panel: ˆ i ˆhCu hCv j⋅ + ⋅ . Third panel: hCu i hCv j⋅ + ⋅ . Bottom panel: ˆ ˆhCu i hCv j...panel: hCu i hCv j⋅ + ⋅ . Second panel: ˆ ˆhCu i hCv j⋅ + ⋅ . Third panel: xv hC . Bottom panelu i hCv j⋅ + ⋅ : ˆ ˆhCu i hCv j...flow fields as in Fig. 31. Top panel: hCu i hCv j⋅ + ⋅ . Second panel: hCu i hCv j⋅ + ⋅ . Third panel: ˆ ˆhCu i hCv j⋅ + ⋅ . Bottom panel: asym

  6. Fleet Mooring Leg Design Program Documentation. Volume 6. Source Listings: Compound Leg Reverse Solutions and Postprocessor.

    DTIC Science & Technology

    1982-12-01

    call CSSHP * wv-ite(1S,*1 h,v-tot if (dabs(rtot-v-t It epsv-i gato 5555 if (nlit eq 100) stop 110 if (ibis eq @I goto 13SO If ((v-tot-r)*(rS-r) It...fmnal/t2for/csexzl for## subroutine CSEXZl :mplicit integer*2 (N)implicit daub Ie precision fa-z) i n t eer*2 i Ieg , ist inca ncb )nwa pnwb i soI i...130,140,150I icon 110 continue par in( L tab I-z( at I goto 200 00 120 continue par’an(&lab)-zltzI*j Od-3 gato 200 130 continue par an I ib I-( dotoni

  7. Clinical features of AIDS patients with Hodgkin's lymphoma with isolated bone marrow involvement: report of 12 cases at a single institution.

    PubMed

    Corti, Marcelo; Villafañe, Maria; Minue, Gonzalo; Campitelli, Ana; Narbaitz, Marina; Gilardi, Leonardo

    2015-03-01

    To study the main clinical and histopathological features of 12 patients with Hodgkin's lymphoma (HL) diagnosed primarily from bone marrow (BM) involvement. We included 12 acquired immunodeficiency syndrome (AIDS) patients with HL assisted in the F. J. Muñiz Infectious Diseases Hospital since January 2002 to December 2013. The diagnosis of HL with primary BM involvement in patients was confirmed by clinical, histopathological, and immunohistochemical findings. All patients presented "B" symptoms and pancytopenia. All of them had stage IV neoplasm disease because of BM infiltration. The median of CD4(+) T-cell counts was 114 cells/μL, and mixed cellularity (MC) was the most frequent histopathological subtype of 92% cases. When other causes are excluded, BM biopsy should be performed in AIDS patients with "B" symptoms and pancytopenia to evaluate BM infiltration by atypical lymphocytes.

  8. FLIR Stabilization Study.

    DTIC Science & Technology

    1982-04-01

    Z ~ Va Lu 1= " I- a:~~ Ci) - wm Q LOLJLL O> C-)i35 IO IzC)W IA i ( A i ZhI 3C2 Lu 3 o0LAJ LnAJ aM L Igoeu L-J z Z ~ -CA cmM C.)3 ’Se I...LL z tz - CIO -c < LLJ LII LAI Z -J 2EC-)>c (A - >- QA V) V)(A 0 LL0 z LU 0 - -;_ C: QLLJ ce z Lz 0L C~=I LL.J V) C0.DA 1 LLU he 0= c- C-) C.)LAJJ...autocorrelation curve samples and the I IL ID IDD 0E 4) t z IL a: __ 0 IV ) I I.- =zJ 0: ILI LJ ~LLJ 0 0z C.)J z CDD

  9. An Object Description Language for Distributed Discrete Event Simulations

    DTIC Science & Technology

    2001-05-24

    given a universe Up, we define a system SRXpT over a collection of parameters RcP ’ as SR XPT E-lrV xeRUT (2-5) We then define r:pT--->SR such that iz...View2D::zNear - This is the near clipping plane. float gvm::View2D::zFar - This is the far clipping plane Public Constructors: gvm::View2D::View2D...of the view. GLdouble gvm::View3D::scale - Zooming factor of the scale. GLdouble gvm::View3D::zNear - Near clipping plane. GLdouble gvm::View3D::zFar

  10. UVR-induced G-C to C-G transversions from oxidative DNA damage.

    PubMed

    Kino, Katsuhito; Sugiyama, Hiroshi

    2005-04-01

    Many oxidizing agents induce G-C to T-A and G-C to C-G transversions, and the frequency largely depends on the oxidative conditions. Guanine is the most oxidizable base among natural bases. The typical oxidative lesion product 8-oxoguanine (8-oxoG) is responsible for G-C to T-A transversion but not for G-C to C-G transversion, and 8-oxoG is more readily oxidized than guanine because of its lowered ionization potential. Recently, imidazolone (Iz), guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) have been demonstrated as oxidative lesion products of guanine and 8-oxoG, which could be responsible for G-C to C-G transversions by forming specific base pair formations.

  11. The Relative Entropy of a Random Vector with Respect to Another Random Vector.

    DTIC Science & Technology

    1985-10-01

    u (T = p (TfnX+) (1.2.4.2) Z+ CUs+S+sS P -(T - sup I u(TfnZ-) - -(T nUzZ) = -u(T nX-) (1.2.4.3) .Z-e U S_ s s s * lH(T) - sup [ 1p( TrIZ s )I = sup...belongs to the Author; the proof uses the method used in [3], page 203 in a particular case. Lemma 1.3 - In the case r = 2, part a) is proved in [1...represents an amelioration of a statement in [8] , and it belongs to the Author, even that methods from [8] are used. 66 Theorem 1.9 - while following the

  12. Surface Observation Climatic Summaries

    DTIC Science & Technology

    1989-09-01

    8217-.JJU:TS J LTC S14A4.)I.1JZ TriZ RUSSAJ (E~S 3J FACE EAT-iz5 ; l1-:rEATIN) AA3 LISJOS (LIMITEI) SURFACT SUM𔃾ARY). t.USSA.*1S AND LIS"’CS 󈧱W INL...GREATEST 82 86 89 92 98 102 104 105 THE GREATEST VALUE OF 105 OCCURRED ON 08/30/54 NOTE: *THE VALUE IS BASED ON A MONTH WITH LESS THAN 90% OF THE 0 E...18 24 31 44 53 57 57 THE LEAST VALUE OF 10 OCCURRED ON 01/11/62 NOTE: *THE VALUE IS BASED ON A MONTH WITH LESS THAN 90% OF THE E - 3 - 26 1 .Y MINIMUM

  13. The effects of selected pre-treatments on germination of seeds of Oriental hornbeam (Carpinus orientalis).

    PubMed

    Ozel, Halil Bariş

    2016-07-01

    In the present study, the effect of some pre-treatments implemented on seeds of Oriental hornbeam (Carpinus orientalis), which has wide geographical variation along Turkey on germination percentage values were investigated. For this purpose, 13 different pre-treatments were implemented to seeds obtained from 17 different populations. According to the obtained results (except control seeds), pre-treatments leading to lowest germination percentage value (8.1%) in Oriental hornbeam seeds was PT10: Keeping seeds for 90 min in sulfuric acid, while highest germination percentage (86.58%) has been obtained with pre-treatment PT13: Implementation of 40% dose of Baikal EM1 + Biohoumous mixture to the seeds, while lowest germination percentage (40.50%) was observed on seeds collected from P7 (Bartin-Kozcağiz) population, highest germination percentage was observed in seeds obtained from P17 (Artvin-Hopa) population.

  14. [Disseminated infection due to Penicillium marneffei related to HIV infection: first observation in Argentina].

    PubMed

    Santiso, Gabriela; Chediak, Viviana; Maiolo, Elena; Mujica, María T; San Juan, Jorge; Arechavala, Alicia; Negroni, Ricardo

    2011-01-01

    The first case observed in Argentina of AIDS-related human penicillosis is herein presented. The patient was a six- teen year-old young man coming from a rural area of southern China. He was admitted at the F. J. Muñiz Hospital of Buenos Aires city with severe pneumonia and adult respiratory distress. Penicillium marneffei was isolated from bronchoalveolar lavage fuid and was microscopically observed in a skin cytodiagnosis. P. marneffei identification was confirmed by rRNA amplification and its phenotypic characteristics. The patient suffered an advanced HIV infection and also presented several AIDS-related diseases due to CMV, nosocomial bacterial infections and Pneumocystis jirovecii which led to a fatal outcome.

  15. Cable Splicing Project/Maintenance Action AFSC 361X1

    DTIC Science & Technology

    1991-01-01

    standards for subordinates 53 D88 Evaluate progress of trainees 53 C55 Evaluate project drawings or specifications 52 25 LU - - K LUJ -x cr O L z nmtjCiCJ...0U co 0 ~ U). m u.. L -a cU+ 0. mL-~ S- 4-- CO x E S- Ln O : .0 0 *- u CL K ~ 0 a> ) C_ UL S.- (v a) nU -r Ln CA CU - S 0.- o ) a 04 0 - W -0 I_- -3...CU U) u cL E- U O D U)c -0 E a) .- (4--C-LA - S- a ) C - U )r - s- UU U 0..a’oIz K CU .- c () LL 0 U - a~ )U 0 . ’-C CU’ca) 4- --=DS- C -- D-C > 4-0

  16. 20301A Assault Breaker, Missile Number FTV-1, Round Number VIGI, 31 March 1981.

    DTIC Science & Technology

    1981-03-01

    W -C D00F ~ * N N - i n- l- CFr vv r .% r , -4I P - O l ’ 0D -q : z I OC4 c C n% Yf)W lC F 0N6 0N% CP LA AC VC ~ r)p)W ni) v4 t ,k nU ) L C10I 0P .P oa...LAi -. P-% ’n-409D? -P)- P nP - 1P n0 n - 1C l l \\ 44 D- CC CI oWC of -f.r ," . 01 01 D1 0% n6 nu ) L A0e I-Z I0L 0 - L&1 *4 * * * .4 NN UN’ in-. 0 W~f

  17. Information Analysis Center Contributions to DoD Key Technologies. Volume 2

    DTIC Science & Technology

    1993-11-01

    C’) LI LU LU > 0 U 1 mW EL. IA ID cc( * CL) IU 0 * VoU a z uJI( l J c i- Iz I~ Ii z I cc I 06 O)C! wL Ic 01;. * 5 0U USo w j w *c I w zI DI I., U< wI...0 ~c 0 a 0 CL >I * 0 cI 7;I I IIO I I !I -- - z cc il %. i2 I All lll’. 1 3lllImm lodo i . -- o o M 0 a t E.o o 0...I I.- o =•_w ’-X" Ou4w. 0.E _0

  18. Risk Analysis in Support of the Chemical Stockpile Disposal Program (CSDP). Volume 2. Consequence Data

    DTIC Science & Technology

    1987-12-17

    the use of such commercial products. This report may not be cited for purposes of advertisement. 10 00 .- I Iz z ~0 oCL) z c- Vc : 3 0888 88 88 88 0...34 3 333333 00D00 UM;! M OO OO I:!:! 00 0Poll0 M- : 0 0 *I I r’ m Q00 00 00 0 ta0 000 0 0 0 80 00 00 00 0t0 0 0 0 00o0 0 C0 0...Qo0000000000000" QQ00C0 Q 00 a O CD 00 0 00 a0 0 0 00-QQF)mQ0m0 QC0Q 40 L^ILpr 00 - 0 0 N 0 0 00Q0 0 Q0 0w-%N 0N(0 0 00 ( 3 I.- C L L " w.4 inl 9- : 0

  19. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 14. Okinawa Kankyo-Pultrusions Corporation.

    DTIC Science & Technology

    1987-01-01

    r--21 Z % o-.-r-t-r-V(0C (IZ 4 ( A 0O 4 C) CD4 a-t z- 4 l ’ -in Z 0 0 0 0 1.1 -oO tic oo1( a I o oO 0 0 0 0~I& 0 0 0 C) (:)4 (0 04 mz CD 0r2 0r...Cd 0 00 ),.蓐 40 -. 4- 400 go -aci (naOA (a 4ajI a-C a-4460o Al 1 W4 0 44 4 00 0o 0 4 3 1a0 0 4 S N𔃻 00 E O O a 00 001-0C4 ODD- 0. ( AulA ~O a

  20. Machine Learning Search for Gamma-Ray Burst Afterglows in Optical Images

    NASA Astrophysics Data System (ADS)

    Topinka, M.

    2016-06-01

    Thanks to the advances in robotic telescopes, time domain astronomy leads to a large number of transient events detected in images every night. Data mining and machine learning tools used for object classification are presented. The goal is to automatically classify transient events for both further follow-up by a larger telescope and for statistical studies of transient events. Special attention is given to the identification of gamma-ray burst afterglows. Machine learning techniques are used to identify GROND gamma-ray burst afterglow among the astrophysical objects present in the SDSS archival images based on the g'-r', r'-i' and i'-z' color indices. The performance of the support vector machine, random forest and neural network algorithms is compared. A joint meta-classifier, built on top of the individual classifiers, can identify GRB afterglows with the overall accuracy of ≳ 90%.

  1. Size Distributions of Solar Flares and Solar Energetic Particle Events (POSTPRINT)

    DTIC Science & Technology

    2012-09-20

    Letters, 756:L29 (4pp), 2012 September 10 Cliver et al. −5 −4 − 3 −2 2 3 4 5 6 7 8 lo g( N o. o f F la re s/ B in S iz e) M X X10 X100 1 log (SXR...1– 8 Å fluxes of SXR flares associated with >10 MeV proton events with peak fluxes 1 pfu (light blue line); ( 3 ) peak 1– 8 Å fluxes of SXR flares...Table 2); ( 3 ) the peak 1– 8 Å fluxes of 59 SXR flares associated with CMEs with speeds 1000 km s−1 (red line; Yashiro et al. 2006); and (4) the peak

  2. Heat Transfer Testing in the NSWC Hypervelocity Wind Tunnel Utilizing Co-Axial Surface Thermocouples

    DTIC Science & Technology

    1980-03-19

    8217 DT L FILE COPY I NSWC MP 80-151 AD- A225 273 HEAT TRANSFER TESTING IN THE NSWC HYPERVELOCITY WIND TUNNEL UTILIZING I CO-AXIAL SURFACE...ui - z Ur) 2 MIT- UA U*) C> In> (NJ 01 0017 20 U NSWC MP 80-151 Iz It c 06I- U) zII 00a Lii Vl 0 1 2 - cr > zI 0 z U-- 01 OT ’O _ _ _~i 01 01 NSWC MP...CS.LN’X -- - - - -jJ -f- - - - Z r- - - ~ ~ - -- 4 I ------ ----- ----- ----------------------------------- V n A j) r A r% Cr r, -r n rO A r. A A C

  3. Subharmonic Solutions Near an Equilibrium Point for Hamiltonian Systems

    DTIC Science & Technology

    1989-04-01

    Thus A = 0 will be continued as A,(6) = A+ + ... j = 1,2. (2.5) Since the matrix V is invertible, W is nilpotent and, V and W commute, the matrix (eV...Hamiltonian system z JA(t)z + JHt..(z, t) where A(t) is a matrix , fl,(z,t) = o(I z 1) and both A and H are periodic in t. On the linear part of the system we...write the Hamiltonian as H(z, t) = 1(A(t)z, z) + II(z, t) (0.2) where A(t) denotes the Hessian matrix of H at z = 0 and ft(z, t) = o(Iz12) represents the

  4. Ion Trap Quantum Computing

    DTIC Science & Technology

    2011-12-01

    b: [ ] [ ] ξ τ τ ξ τ τ + + = − + = 2 2 2 2 2 cos(2 ) 0, 2 cos(2 ) 0 d x q x d d y q y d (5.7) 21 Mathieu equations have two types of solution ...qz e d (7.10) The solution of this differential equation is in the form of: ττ τ=( ) ( ) iz f e (7.11) Now, if we combine Eq. 7.10 and 7.11 we...are able to eliminate τ* ( )f and get the following fourth-order equation : τ τ + + − = 4 2 2 4 22 (1 4 ) 0 d f d f q f d d (7.12) The solution

  5. Prime Contract Awards by State or Country, Place and Contractor. Part 16 (Fort Hill, Virginia - Chesapeake, Virginia), FY1991

    DTIC Science & Technology

    1991-01-01

    N4 NNN N) N* 4 I4 Uro -4 c" iz If 0)0 In( aI o 0 ~ 0 - o,’ InI m 10 040 0 C)()-0 04 r- -44- P-2 CO-4c, 00 ) C 40 C44 4 0 > C4 444 4 10 I, C I M0-4 040...4w0O"sO0 -a m n 0I--, A0 w n 44O. -0 0 - - qt U)n-(0COU)-- o)4 of0) 1 00 I moo( ON000N hO4(C(( (0 1- In IsLA (0000ULf :, 4i u I 0000 I- Nf (0(0

  6. Battlefield Maintenance and Recovery Module for the Airland Research Model.

    DTIC Science & Technology

    1986-03-01

    8217-’- I -I0 =)13 - E4 z : C) m Ezw 14)W r-4 OE-4 E-1E-W =3: 11 1311 n 4J -4 E-’ Wz 14+ 0i20- - -W-E-4 on - -iz WH 4~~ L"O E-4- t40z0++1 - 10 f) WM::zW0...16 ES- 4-P-1- +4 + I - 3 0 0 1 0 0 -0 4- ii a4 - 04 - a4Z -N.~ 1- C4 13:11 3: kZI 3 EI- o3 0 P- I ZW I - ~ - - - 4 3I P I EZW I HN-N N N-N 44tI -I

  7. USAF Bioenvironmental Noise Data Handbook. Volume 5. MA-1A Power Unit, Gas Turbine Engine (Continental)

    DTIC Science & Technology

    1975-06-01

    w =jI Wo I~t to - I 0 I I DM Z IWI Ui J Ito 00 I =I-4 CI EZW 1 I O tco 1-44 -- Zu lit 41L5 I 0 - -------- -- - -.------------ --- N I I 1 0 I 1 cm I...Z Z Ci i BIi 1D 4 -j 0 BC’) B1 BB -’ 4 H BM BW4 B -0. I I) w ~ U B3 U BI Be IBI.- H I I L A . B0- B CUL B! I IJ ( Il- 1 ) 4 W I I I C B 1~ BC BB )- 3...w.4 I t i I I LL. LL II. C I~~~~~ . c.CCC L!~ II’ W 0 1D C * 1 TL 1it .. . ... . . ... ............ I’ C It I1 .e ’I ’ e c .- c e c c c4. * c * 3 3

  8. Installation Restoration Program. Stage 3. Remedial Investigation/ Feasibility Study. Elmendorf Air Force Base, Alaska. Volume 4. Appendices D-F

    DTIC Science & Technology

    1990-05-01

    6 1 "D - I t_ _ qd 4Yr (..2 _ IIA 1 -d I__ z__ - /Ao -~ && -) 15 )321 A- /1" 0 I U~MPLf TyPS Wat O APE IhO. (WSAOl)wu cbm wcCOOE 0. OUPUCATIE U. PIEL ...21 58.0 SE IZ VV.il0 #? i 11.529 281 121, f - 4. CLOSING PT: 122, NE 󈧄vG RG I W.A ;- ERROR qOt.0-A BALANCE RIZONTAL CLOSURE NE 81 09 09.4 4,324.4914...SE 17 09 20.4 11.529 281 21 CLOSING PT: 122, NE 0 00 00.0 REF ERG 162 50 39.6 ANG ERROR 0 00 00.0 ANG BALANCE I C-RIZONTAL CLOSURE NE 81 09 09 .4

  9. Hybrid LTA Vehicle Controllability as Affected by Thruster Magnitude and Spacing

    DTIC Science & Technology

    1977-07-01

    0 0 0 0 g3 " e Ŗ 2 Xrtr Tc y ft.lb. 5,994,960 5,9 285.756,4911 5,526,954 r - a IZ r~rl td .2 Z eec 292 Yrtr TP 4-ztim If gi), /•M&Y TY T n T - gT...Mz - z max " trim rd. () b Yrtr X.nax -m Xna (1b TPX j’ax/TZ total 1,560 /030tota -rad. .069) .0495 .0218 -. 0122 6,500 .125 . td . 0919 .0721 .0444...If gl _• I~= ’. an~d TR 1 - 2 (g - T a ).. . . ..T- raz. 1Y Ti max 1 and TD i 0 4 lb. 1 0 1,725 4.537 9,394 Y D T lb. 0 0 0 0 9 3 cl Ŗ - 2 X rt T T

  10. Meteorological Influences on Smoke/Obscurant Effectiveness. Phase 2. Volume 1

    DTIC Science & Technology

    1991-11-01

    I I I 1 Iz 0 00.. 0U CI III I I I 4II’ I- .- 0 .00 Q 0o F.0.1-2 es~mn gi o deelpen ts I f 9m pra 0-0 000 a C 0 I 0 0 0. 0I 0 00 0 0 0 I 0- V to Ci uj...0Lni 0 - 10-24 -4 > 00 Q 03 L. to 41 0 0 . - 0 - au I. L.. O ~ . al 41 Cu .0 000 ’o 1% mu ti, 0. 00% U~c -1. f 04o 02c c 00 N L. 6.- o* ~ . 01 0 - 0 -0...ecological models," Methodology In Systems Modeling and Simulation. (B.P. Zeigler, M.S. Elzas , G.J. Klir and T.I. Oren, eds.), North Holland Publishing Co

  11. Worldwide Report, Arms Control.

    DTIC Science & Technology

    2007-11-02

    will regulating th7 nonprolifSon ofIZ^^ ° f the international system of ovurcort~^ ?it^.^.Xl^uoS^^tT^*"^ t0 PlaCe «"" IAEA...DromLf*™Cle!? «*ivlty in our country will, monitoring by this 1^^"^ ° f ^ ■»<" ° f ä^I^t^irTl^JJr ""V* inst"utions of IAEA are situated, the...agency for the purpose of’workTn* f ^A**10ŗ between the USSR and governing7 IAEA guarantees wit^re^ecf t’o o^rt ^"A0" ° f "" agreement activity in

  12. Significance of symmetry in the nuclear spin Hamiltonian for efficient heteronuclear dipolar decoupling in solid-state NMR: A Floquet description of supercycled rCW schemes.

    PubMed

    Equbal, Asif; Shankar, Ravi; Leskes, Michal; Vega, Shimon; Nielsen, Niels Chr; Madhu, P K

    2017-03-14

    Symmetry plays an important role in the retention or annihilation of a desired interaction Hamiltonian in NMR experiments. Here, we explore the role of symmetry in the radio-frequency interaction frame Hamiltonian of the refocused-continuous-wave (rCW) pulse scheme that leads to efficient (1)H heteronuclear decoupling in solid-state NMR. It is demonstrated that anti-periodic symmetry of single-spin operators (Ix, Iy, Iz) in the interaction frame can lead to complete annihilation of the (1)H-(1)H homonuclear dipolar coupling effects that induce line broadening in solid-state NMR experiments. This symmetry also plays a critical role in cancelling or minimizing the effect of (1)H chemical-shift anisotropy in the effective Hamiltonian. An analytical description based on Floquet theory is presented here along with experimental evidences to understand the decoupling efficiency of supercycled (concatenated) rCW scheme.

  13. Dynamic Stall Penetration Experiments on a Swept Wing

    DTIC Science & Technology

    1986-09-12

    and process the data. The on- line data processing included computing the ensemble average of the pressure and heat transfer signals, computing the rms...aopl1ns aq; uo jaqwnu 1432W pup ajlei LIYLd SO4 S130442 4UPOL41U6LS smOL4s S4lnsaj 614 40 S!.S,(eUe k (eU.W!L~Ljd V 2)Bs/fbaP OSC Pup S’LI aaBm48q sa~pi 4o d...S4uDW.jadx3 uoL4P40ud LL4S WURGj ON NOISS3:))WI ON ION ION 1N3LA313IsOi io jboA >ISM £)3,’ Obd AbOdd aor S83SAflN DNi0)%2,j O 3)Dflos o (4Pa dIZ Pup

  14. Burlington IAP, Vermont. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    DTIC Science & Technology

    1981-12-23

    PARTS A - F POR FRU HOUWiL OBS: JUN 73 - MAY 81 POW FROM DAL! OBS: JAN 48 - -AT 81 TDI CO VERSION GM TO LST: - 5 DCC 2 3 ISeI ’ ,IS TlO( lw.-. Tt REEN...13Z 8.3 5.1 13.3 7.44 ,1-2’ 1i.Z 1.2 12.I t ,5 3.4 11.2 74 TOTALS 11 2.2. 0 13o8 1O.i 3.1 .0 12.6 551 .GIAL 4TA ’CCODEO IN SYNOPTIC COED " USAMAC polo 0...VARS J ~~~AMOUNTS ,INCHS, IIN __RCENT, TOTAL MONTHLY AMOUNTS PIRCeP MOE ACE 1 01 02. 05 .06.10 j.11-25 26.350 .51-1.0 1.01 2.50 25315300 3101-100 co

  15. A class of exact two-dimensional kinetic current sheet equilibria

    NASA Astrophysics Data System (ADS)

    Yoon, Peter H.; Lui, Anthony T. Y.

    2005-01-01

    The present paper discusses a class of exact two-dimensional kinetic current sheet equilibria. The general solution to the two-dimensional Grad-Shafranov equation was first obtained by Walker in 1915 in terms of the generating function g(ζ) (ζ = X + iZ), where X and Z are two dimensionless spatial coordinates. There are infinite choices of g(ζ), but not every solution yields physically meaningful or mathematically useful form. The known solutions to date with geophysical application include those by [1962], [1965], [1973], [2000], and [2002]. In this paper, these solutions are reviewed systematically, and several new solutions are proposed. These include a generalization of the Harris-Fadeev-Kan-Manankova line of model, a model for an isolated X-line alternative to that of Brittnacher-Whipple, and finally a model which represents an isolated magnetic island.

  16. Ring State for Single Transition Metal Atoms on Boron Nitride on Rh(111)

    NASA Astrophysics Data System (ADS)

    Natterer, Fabian Donat; Patthey, François; Brune, Harald

    2012-08-01

    The low-temperature adsorption of isolated transition metal adatoms (Mn, Co, and Fe) onto hexagonal boron nitride monolayers on Rh(111) creates a bistable adsorption complex. The first state considerably weakens the hexagonal boron nitride- (h-BN-) substrate bond for 60 BN unit cells, leading to a highly symmetric ring in STM images, while the second state is imaged as a conventional adatom and leaves the BN-substrate interaction intact. We demonstrate reversible switching between the two states and, thus, controlled pinning and unpinning of the h-BN layer from the metal substrate. I(z) and dln⁡I/dz curves are used to reveal the BN deformation in the ring state.

  17. Dollar Summary of Federal Supply Classification and Service Category by Company, FY 85. Part 10 (7035-9150).

    DTIC Science & Technology

    1985-01-01

    SiONSORiNG 3b OFFICE SYMBOL 9. PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER (If applicable) i"i ’ y , 51te, and ZIP Code) 10 SOURCE OF FUNDING NUMBERS...0 0 w lee a 0 w * aF a w Y c z Z) 4 <ac z z<Ze a 44 1 lI4 le.- oeel0 lee.-I. 0eelLA Veel I-V 1 e . . leeto c c -. c 44 dc a1 al aL I0c lee C .40U 1...4 Co 4 a a 0a ma 0 z a4mC o~ ~ . I-- I. <-m I-- wn a n a n a n a n annwn a a n a n a-~ y - I-Z aaa a. a a . a. a .- a. a. a. m~a a . a . a . a ma -C

  18. Fixed-Cone Valves, New Melones Dam, California. Hydraulic Model Investigation.

    DTIC Science & Technology

    1981-04-01

    The discharge coefficient C in the equation, Q = CA 2 gH where Q = discharge, cfs A = area of conduit immediately upstream of valve, ft2 g...27.7 in. Sleeve Travel = 20.2 in. Sleeve Travel = 1.2 in. Sleeve Travel = 9.7 in. No. = 1730 cfs q = 1590 Cf Q = 1340 cfs Q = 1050 efs 500 127.0...4 z 0 CD, z w w iz 0 w -i LU mt IJJ 0 LU toooz > z L 0 LU ww z 00c 0 uLU > - > >i uj PLATE 5 00 _ _ _~II ___ _ 8 0 0. 0 IAJ z ____ 0 L Q -LJ &hJ ICl

  19. Arbitrarily shaped scatterer by moment method

    NASA Astrophysics Data System (ADS)

    Shu, Yongze; Ma, Feng

    1988-12-01

    The calculation of radar cross section (RCS) for an arbitrarily shaped and perfectly conducting scatterer with small electric size has been studied by moment method. The starting point of this paper is the reaction integral equation (RIE). Polygonal plates are used to construct models of realistic structures and to segment every plate into modes automatically. Overlap modes can be obtained between the connecting intersecting plates. The piecewise-sinusoidal modes have been chosen as expansion and testing functions. From RIE, the matrix equation IZ = V can be derived. The scattering field and RCS of the scatterer can be obtained. The method has advantages of simplicity and flexibility of input, versatility, and accuracy. The calculating results of RCS for a few scatterers with different shapes, including a realistic rocket, have been given. The results are in good agreement with those published abroad.

  20. Significance of symmetry in the nuclear spin Hamiltonian for efficient heteronuclear dipolar decoupling in solid-state NMR: A Floquet description of supercycled rCW schemes

    NASA Astrophysics Data System (ADS)

    Equbal, Asif; Shankar, Ravi; Leskes, Michal; Vega, Shimon; Nielsen, Niels Chr.; Madhu, P. K.

    2017-03-01

    Symmetry plays an important role in the retention or annihilation of a desired interaction Hamiltonian in NMR experiments. Here, we explore the role of symmetry in the radio-frequency interaction frame Hamiltonian of the refocused-continuous-wave (rCW) pulse scheme that leads to efficient 1H heteronuclear decoupling in solid-state NMR. It is demonstrated that anti-periodic symmetry of single-spin operators (Ix, Iy, Iz) in the interaction frame can lead to complete annihilation of the 1H-1H homonuclear dipolar coupling effects that induce line broadening in solid-state NMR experiments. This symmetry also plays a critical role in cancelling or minimizing the effect of 1H chemical-shift anisotropy in the effective Hamiltonian. An analytical description based on Floquet theory is presented here along with experimental evidences to understand the decoupling efficiency of supercycled (concatenated) rCW scheme.

  1. The DECam Gravitational Waves Follow-up Program

    NASA Astrophysics Data System (ADS)

    Soares-Santos, Marcelle; Dark Energy Survey Collaboration

    2016-03-01

    We report on the status of a program to search for the optical counterparts of gravitational wave sources using the Dark Energy camera (DECam) on the Blanco 4-m telescope at CTIO. This program is a joint effort between the community and the Dark Energy Survey (DES). DECam has a 3 sq-deg field of view, and typically reaches a limiting magnitude of i,z = 23 for 90 sec exposure times. As such it is one of the most efficient and rapid instruments for deep searches of the large gravitational wave error regions. In this talk we describe our observing strategies and on-going efforts based on the first Advanced LIGO science run.

  2. Prime Contract Awards by $100,000 or More by Federal Supply Classification or Service Category and Purchasing Office. Part 2 (5810 Communications Security Equip and Comps 9999Misc Items)

    DTIC Science & Technology

    1990-01-01

    ZOO XZ0.000O. Z 00 03 .L WO La. OS-4 .0.0..La. 00 L. r4 - 0 4444444ZZZZZZZZZZZZZZZZZZZZZzzz4- ode (0j w0 04 qr L Z40 (D4 "o - wo...zj in C- 1.4 TM 30 40 UO - C . (4 C.) 0a 0 040 In In . I (A LAJ 0or- a W-o CM C -U) _iz Ř CV)C4I’- V 4Ci U 4 0 C4 C0 U)o MU 1 0 up >0 0.9 Porn 0* i...10 "- 000N0 CV 4 Un In In (D InU w 0). 1 1-. 04 z 0 C1 -4 C U) 0 4 00 >0 4 0 <- e wn l ~ 00 30. Go- 40 UCM m 0 C L U. L aoX 0 L . d 40006 o Zoo

  3. MX Siting Investigation. Geotechnical Evaluation. Aggregate Resources Study, Hamlin Valley, Nevada-Utah.

    DTIC Science & Technology

    1980-06-06

    AND ADDRESS 12. REPORT DATE ~)V~L’~ ()~L\\ ~ L~c~ O A󈧑* NUMBER OF PAGES, I’c---t (::..-h -- ( c C- 1t𔄁 "’ ( ... j ... o . - . .,u - ;=z 13, Iz - .. ,1W.)Pl put £ .. j ~ "Wljw vu a Eiiaa ... f~cmse- E~ E - 1 u~ln~al Pfa to a . a s up’:I j m mI .iIIz i Ia ji j *; %I r. j ... J 1105I, $111 51i~ Slyl S01 bI iSlI0~ b l Ib- Su, QTz -- id o ................ .... .......b~* 55 Ls, Do, Cau .byl l....... I MU - D z., CS, S .s

  4. [Clinical problems in medical mycology: Problem number 50].

    PubMed

    Walker, Laura Guadalupe; Arechavala, Alicia; Messina, Fernando; Negroni, Ricardo; Santiso, Gabriela

    We present the case of a 34 year-old man, HIV-positive, who had suffered a disseminated histoplasmosis treated with amphotericin B one year before his admission. He was admitted at the Infectious Diseases Muñiz Hospital with a non-lithiasic chlolecystitis. During the clinical examination perigenital skin lesions compatible with tinea cruris, as well as proximal subungual onychomycoses of toenails, were observed. Microsporum gypseum was isolated from both types of lesions. Oral terbinafine led to a good clinical response. Treatment prescription was a big challenge in this patient because he was receiving HAART and itraconazole, and there was scarce experience in the treatment of nail infections due to M. gypseum.

  5. [Clinical problems in medical mycology: Problem number 47].

    PubMed

    Corti, Marcelo; Muzzio, Estela; Villafañe, María Florencia; Priarone, María Marta; Messina, Fernando; Arechavala, Alicia; Maiolo, Elena; Negroni, Ricardo; Franze, Oscar

    2013-01-01

    A 66 year-old man, who had lived in Paraguay and was a rural worker, was admitted to Infectious Diseases Hospital F. J. Muñiz in Buenos Aires. He presented fever, loss of body weight, cough, mucopurulent expectoration, wide perianal ulceration, paresthesia and paresis of both legs as well as vesical and anal sphincter dysfunction. He was a heavy smoker and drinker. Thorax X-ray examination showed bilateral micronodular interstitial lesions. With a NMR of the dorsolumbar spine region a nodular lesion outside the spinal cord (which produced compression of this organ) was shown. The diagnosis of disseminated paracoccidiodomycosis was based on the finding of Paracoccidioides brasiliensis in the skin ulcer in histopathology and mycology studies, and on the positive results of serologic tests with paracoccidioidin antigen. The patient was treated with trimethoprim-sulfamethoxazole with good clinical outcome.

  6. Fastener Hole Quality. Volume 2

    DTIC Science & Technology

    1978-12-01

    i TEST TRAM: 1. 2T 4 5 O Z7W AVER~ AGE VIMRT: 3.07 060 0191o z AVERAGE Tcxs-.,Si 2 860 n i4.*k- 2760 (nI2 o _______ AREA:_____ 2660_______ BASELINE...LOAD: 19777 goAn (n ag ,•’ 71 gn 4o ( 7 3 , - CYCLES AT TERMINATION/ IZ: 3Ives/_ ___n l’ A D 2,7.7 l’ 1so: I I _Z. 1680 -066s 6 at?- .. ign 0!𔃿t7...TEST DATE: _-32 12800 2-6 _. , 31 1240030 12000 6 1d RAG WIDTH: S.oo( -29 11600 6 % OtO c5 n 1l AGE 28 11200 1 % I do t4-S,7/78,... -2ś 10so00

  7. Comparison of Transition Metal-Mediated Oxidation Reactions of Guanine in Nucleoside and Single-Stranded Oligodeoxynucleotide Contexts.

    PubMed

    Ghude, Pranjali; Schallenberger, Mark A; Fleming, Aaron M; Muller, James G; Burrows, Cynthia J

    2011-04-15

    As the most readily oxidized of DNA's four natural bases, guanine is a prime target for attack by reactive oxygen species (ROS) and transition metal-mediated oxidants. The oxidation products of a modified guanosine nucleoside and of a single-stranded oligodeoxynucleotide, 5'-d(TTTTTTTGTTTTTTT)-3' have been studied using oxidants that include Co(II), Ni(II), and Ir(IV) compounds as well as photochemically generated oxidants such as sulphate radical, electron-transfer agents (riboflavin) and singlet oxygen. The oxidized lesions formed include spiroiminodihydantoin (Sp), guanidinohydantoin (Gh), imidazolone (Iz), oxazolone (Z) and 5-carboxamido-5-formamido-2-iminohydantion (2-Ih) nucleosides with a high degree of dependence on the exact oxidation system employed. Interestingly, a nickel(II) macrocyclic complex in conjunction with KHSO(5) leads to the recently reported 2-Ih heterocycle as the major product in both the nucleoside and oligonucleotide contexts.

  8. Feasibility of Obtaining Hypervelocity Acceleration Using Propellant Lined Launch Tubes

    DTIC Science & Technology

    1970-10-01

    34 Combustion and Flame, Vol. 12, No.3, 1968, pp. 201-216. 281Hightower, J. D. and Price , E. W., "Two Dimensional Experiments On Studies of the Comustion...TESTS FILM PROPELLANT - VELOC -T- (n’. TO No. DATE PRESSURE THICKNESS mcSCOAT (mils) KNO3 510,1b4 PVC 1-2 2-3 1-3 1IO/01/69 Atmos. 3.67 45% 45/, 10X% 51.3...34 j VELOCITY (in/sec) TOP NO. DATE PRESSURE THICKNESS Mc/S COAT (mils) KNO3 510,164 PVCI I-Z 2-3 1-3 29 ,0/15/b9 Atmos 11.3 333 1000 500 30 11.67 253

  9. Monte Carlo Bayesian System Reliability and MTBF-Confidence Assessment, II. Volume 2. SPARCS-2 Users Manual

    DTIC Science & Technology

    1978-03-01

    STEM ANo ITS OH/LES -U*b00000LO IA ANO CLPONENT FAILURT-VIST HATA. MINIMAL STATES AEE RIR P 𔃺. 00OOOIAO iF PARS. E3R ’RELIABILITY- ANALY S 0 l CUTS FOR...SYSTEM RELIUMILITT. II FDA *EUOoUT1TI S, STEM LMf.MELIILITI. ’EUMUo * iz IN is -s MM ISSTOM TIME -NITS. ALPHARETIC M/00001730 /AM OFET OkAL). /Eoooo...00010300 9 TO;iI Il - 0I; COODIOOBO SŔ ENOI 00010590 Say IF -I1 TIEN GO TO ONES 0D010D00 588 BE TI?.": 0010410 5s: 190 ; STELL SORT *2 0001040D / 8/D0001

  10. Prime Contractors with Awards over $25,000 by Name, Location, and Contract Number. Part 6 (RGI Inc, San Diego, California -- Technology Specialist Inc, Arlington, Virginia), FY1991

    DTIC Science & Technology

    1991-01-01

    0 0 : r ( a. I L ID U I I m> 00 En 00 ZZ3 I a.-U) .U -. I F5. 1 6 I D0 0n Iz 000 u 00 0 I 000 : 00 I 00 I n - I L) I m Il- .4-1 al L)C...Lo (Y0C).-4-4-4> tn 0 -4 to-4 4. in C- w m 4 > 0a08 to C 0 00000> 0 CD 6 ~~ 0000 000 0 84t 00V4N a U ~ 0 00 0 0 00 004 r )L) E )L)L )L al wmm m 4 m m4...Cc, - 6 M w4 01~c - 0 0 9a H00 9 w o H a HH a HHHH a HH 0 H Z 0 0

  11. Technology Insertion-Engineering Services Process Characterization. Task Order No. 1. Book 3 of 3. Database Documentation Book. OO-ALC MANPGW (Brakes - Profiles)

    DTIC Science & Technology

    1989-12-15

    l 17%’ if- I- 0 L1L1 -I I I -1--- 00 U)) co 4Z0 J I cc I I IK IL I I IL I - - - I 0 I I I I- I I -I alI I l ol : IZ ICA a .~ I MEI I 0~ .~ I I 0-I ImeI...DRILL AND TAP OLE . 5250W .1525 0020 E RJP-PW-R1 1.00 REM RPI. PAPRWRK SIGN OFF DOC .01001 .010 9000 JA 01 00 .00 LABOR STANDRD HISTORY .000 .000 .000...CLEANED A-ND PROTECTE:’i (C/P MOVE) FOR __________ MOVES BETWIEEN O.-PERA-T :OEN/D:. ESPA *T(H _____ _____ ______ STA1T IONS. :~ 4::: 4 :::: . . *W A

  12. Mid-Infrared Variability of Our New Nearby Neighbor

    NASA Astrophysics Data System (ADS)

    Radigan, Jacqueline; Buenzli, Esther; Apai, Daniel; Cowan, Nicholas; Burgasser, Adam; Triaud, Amaury; Gillon, Michael; Faherty, Jacqueline; Plachvan, Peter; Beletsky, Yuri; Morrell, Nidia

    2013-10-01

    Recently, the discovery of a brown dwarf binary only 2 parsecs from the sun was announced, making it our 3rd closest neighbor after Alpha-Centauri and Barnard's star (Luhman et al. 2013). Incredibly, large-amplitude variability (11% in an i+z filter) was announced for the secondary ~T0 component shortly after (Gillon et al. 2013), indicative of patchy clouds. Here we propose to obtain time series observations of this benchmark system with Spitzer to probe cloud structure in its upper atmosphere. As the only brown dwarf system whose mass can be independently constrained from an orbital measurement, and whose 3D clouds structure can be probed from time-domain studies, the Luhman 16 system provides singular opportunity to investigate the sensitive dependence of cloud structure at the L/T transition on effective temperature and surface gravity.

  13. Charge Transfer Between Quantum Dots and Peptide-Coupled Redox Complexes

    DTIC Science & Technology

    2009-01-01

    scale ) Ruthenium complex 190 2009 NRL REVIEW NANOSCIENCE TECHNOLOGY N or m al iz ed C ur re nt (µ A ) Potential, V vs...DHLA QDs Abs 2 Ru /QD Abs 5 Ru /QD FIGURE 4 Enzymatic assay of chymotrypsin activity utilizing QD–Ru peptide conjugates, showing enzymatic ve ...0.01 0.02 0.03 0.04 Vmax = 0.04 +/- 0.02 µM/min KM = 0.83 +/- 0.16 µM KM = 2.2 +/- 0.5 µM Vmax = 0.01 +/- 0.004 µM/min No inhibitor + Chymostatin inhibitor V el oc ity (µ M C hy m -R u cl ea ve d

  14. 3D analysis of posturo-kinetic coordination associated with a climbing task in children and teenagers.

    PubMed

    Testa, M; Martin, L; Debû, B

    2003-01-09

    The aim of this study was to characterize the modifications of the posturo-kinetic coordination during a climbing task as a function of postural and/or movement constraints in children (8-10 years) and adolescents (10-15 years). A 3D-analysis of forces was recorded for different movement amplitudes and types of holds. The results show the involvement of horizontal and vertical forces to maintain equilibrium during the steady state changes for different experimental groups. The contribution of horizontal and vertical forces changes in the course of movement realization. The vertical momentum (Iz) is mainly involved in the movement initiation: this role is mostly meaning for children. The horizontal momentum (Ih) is mainly involved in controlling equilibrium: this role is mostly meaning for adolescents.

  15. Relation between the Surface Friction of Plates and their Statistical Microgeometry

    DTIC Science & Technology

    1980-01-01

    io -*0 __ _ 0.0025f-_ __ 0. o0 2 z𔃺’,O 2. Z𔃿 3 ,, 4 S 0 7 & ŝ ;0O’ Scale for-R F /- 7 AtY A - Froude - 10’, Z5, 50’ Planks F -Maecsured Resistance...Lbs.) o - Washing..on -O’and 30’ Planks A- Wetted Surface (FP? ) o - Gebers- ubigau - 0, IGO, 30.4 G, 5 cm P!c* o - Density 0 - Gebers- Vienn -iZ5...34I - Kinematic ViscosiTy C - Wash*ngton- 80’ Plonk,with Butt Staps S-Kempf and Kloess-50, 75cm. Planks 0.0.41 A . 0.0015 107 1.5 -a 2.5 .3 4 5 7 8

  16. Flood Control and Other Water-Related Purposes, Wyaconda River Basin, Missouri and Iowa. Revision

    DTIC Science & Technology

    1991-12-01

    ykig.inrus), coyote Qn ait jans , gray fox (!Jrocyon cine -.e~argnteu), red fox (Vulpes vtij]W), raccoon (Procyon lotor) stiiped s’- k (Mephitis mephitis...L3 N- 0 CD CD In 30 0- 4c f- LUz 0I 4- 00 < - I- >) -- w~ W-. Mg OH w z -dk - 0 0 0 (w r- 2 -w i’ z 51 w - .-. .Z 00 - 0 0 >( 0 n.C z -_j 0 (- P- w .- I...Z0 . ) I o Z ~ > 0. ( 0j "- 1’ ) C r 0 ) 4 C .4 0 𔃽LU4 -0 0 >C W u LUZ Q N Cr 0 < -0 o (A-) 10- 0z 0 00) X 10 .Cr I LU --4 oi) 4U 44 < a 0LO.-. LU 0

  17. Word Criticality Analysis. MOS: 57H. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-09-01

    CATIIEE C -3-12,6 3-- 10. C 3 - 13,4 - -I CALlIt0 1- 96,1 3- S,1 1- 96,1 1 97T1 I’) I LHIAFING 3- 5, 1 1.- 2Ct .,1 3-205,1 1- 93,1 I- 66,1 I CHIN 3-169,Z 3...1- 16,1 1- 1.5 34- I3,5 1- 61t.1 3 ".1 q 70. 3 71.l .11 F4NDL(R ŗ- 20,1 I tD R 3-I79i1 I 3-177,1 -%- 17F. 3-17501 -172i2 IZ�,1 -170.1 1-169i1 I

  18. Performance Oriented Packaging Testing of Container, Shipping and Storage, CNU-234/E for Packing Group 2 Solid Hazardous Materials

    DTIC Science & Technology

    1992-01-01

    Container Type: 1A2 Container P/N or NSN: 8E 8140 - 01 -045-7201 Specification Number: Material: 799AS100 Steel Cylinder and Skids Gross Weight: Dimensions...REL. ITAR). Block 3. -, pe of Report and Dates Covered. DOD -See DoDD 5230.24, "Distribution State whether reprt~ is interrn, final, etc...I I I I I I I IT -: I Iq I Iq Iz -I -4 - 4 -4 - 4 -4 - 4 -4 -4 -4 -4 -4 -4 -4 -4 o o 0n 0 0 0 01 0n 0 0N 0z 0n 0 0 0 0 0N T (-’ E-4 H- H4 H0-HHHHH -H

  19. Characterizing the Sensitivity, Selectivity, and Reversibility of the Metal-Doped Phthalocyanine Thin-Films Used with the Interdigitated Gate Electrode Field-Effect Transistor (IGEFET) to Detect Organophosphorous Compounds and Nitrogen Dioxide

    DTIC Science & Technology

    1991-12-01

    rovedREPORT DOCUMENTATION PAGE 0MB No 0704-0188 0,o’ -’ r’ n _ ’r: 2t~ t or, , on s . st- a3 d t, )e~viqe - cJ ze, -- s acr~e. - !virg::, t , -e...established by reviewing the previous research accomplished by Jenkins [7:5-13,15], Shin [22:IV-7] and Hamann [5:77]. This bias level is a ’best pick’ choice...z., C4 ____ ___ ___ z c &-c J- ~ . M4J 41- D-32 xM v .2 t cQ c 4~- 04CC D-33 -~-z lb IL " ; i.. ɜ. - ~ D-34 ~0 zoz 0 tU C - Cj 7 Y’ -C- IZ~A !5 4- W

  20. Public Works Center Pearl Harbor Fleet Moorings Underwater Inspection Report.

    DTIC Science & Technology

    1983-09-01

    CHESNAVFACENGCOM REPORT FPO-1-83, "PWC PEARL HARBOR FLEET MOORINGS INSPECTION REPORT... -’..-.-..;-.-. . s,’. v V’* vi. 0.0 o 4. t!J IA -0 iiiA a𔃼 𔃺’ CL :2I...8217 . . 7 - - - -- - - ". iA Avi << o, .t2.% -AAl ZLI. ,1* . . . . . . . . 4 vi * U)A 0 a 7 -uj z .13 Zn x- -I-z 0 z d= -3 I =- I u2 (N N I...I * * J .p II VI%’ I1. IA IIIq 9> <-- - - - - - - - - - _us: * > 13 Z - - - -A- - zz C6 aa wi a 06 > cc - - _=j = - =Il p 2 Z

  1. Isomonodromic deformations and SU 2-invariant instantons on S4

    NASA Astrophysics Data System (ADS)

    Manasliski, Richard Muñiz

    2009-07-01

    Anti-self-dual (ASD) solutions to the Yang-Mills equation (or instantons) over an anti-self-dual 4-manifold, which are invariant under an appropriate action of a three-dimensional Lie group, give rise, via twistor construction, to isomonodromic deformations of connections on CP having four simple singularities. As is well known, such deformations are governed by the sixth Painlevé equation P VI(α,β,γ,δ). We work out the particular case of the SU-action on S4, obtained from the irreducible representation on R5. In particular, we express the parameters (α,β,γ,δ) in terms of the instanton number. The present paper contains the proof of the result announced in [Richard Muñiz Manasliski, Painlevé VI equation from invariant instantons, in: Geometric and Topological Methods for Quantum field theory, Contemp. Math., vol. 434, Amer. Math. Soc., Providence, RI, 2007, pp. 215-222].

  2. Self-Healing Coatings with Multi-Level Protection Based on Active Nanocontainers

    DTIC Science & Technology

    2009-02-01

    of the coating functionalities due to a real healing of the defect retrieving initial coating integrity •R.S. Trask, G.J. Williams, I.P.Bond, J. R...polyelectrolyte nanocontainers for inhibitor encapsulation 0 1 2 3 4 5 70 80 90 100 SiO 2 / PEI SiO 2 a v . p a rt ic le s iz e , n m Layer number...SiO 2 / PEI /PSS SiO 2 / PEI /PSS/BT SiO 2 / PEI /PSS/BT/PSS/BT SiO 2 / PEI /PSS/BT/PSS Layer by Layer assembling process M.L.Zheludkevich, D.G.Shchukin

  3. Alphabetic List of all DoD Prime Contractors, FY 88.

    DTIC Science & Technology

    1988-01-01

    V) oo o 2 ___ m__ 0 I)u00 9H %I EI uE48Z MOD Z ) 01 § 1 Cc U., P 0 0) 4 C) I-I 0 I’-4 CO ECC 2-40 0020402 ") z 44I ൹--4- 01N2 0 1U-4Z 9- I -X0: l 40...2 IL 0 lot 9-40~"" no HOMO - 200 -~oH 4 0 IZS’ 00 2 z~0sS0 0- 00 QI4I m 0 ’C a~09 40Q t 8 014 to 0 I.4V 8 , N 1 0 .49-49-8 - 00 01-04 o1-4 4 u 0 0

  4. All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 6. Washington, DC-Zephyrhills, Florida.

    DTIC Science & Technology

    1987-01-01

    C40V00000040000004C qC 0 0C00000 00 Woo0 zoo0 0000000000 000 0 403 Ř(100((I00O00i( <n -C) 00 w<�~ 0 Im 8 X 20000 00 M 2 - 2 LLLJJ2 zzz z V> 20 w I4...C W t .000000 0 0-4 (DtoM(- 04 < mi~wwmxxImxxIZ W<< mooo N 20000 "<< 011J <-44 W4 4 I c 00ml 0000000000000000 JUL) WNNP4NtNN ON 0. 200 L UU I I- - W...P,-- 0000 60 00to0- Oc . $ CO 64 00 0000*c0000 0000 00000000 00 0000 0000000 0000 20000 0000 00 200IO00 000 I-400 -14 0( 0)60) M Ot 4-4.f -. 4-4 1- r

  5. A Numerical Model for the Computation of Radiance Distributions in Natural Waters with Wind-Roughened Surfaces, Part 2: User’s Guide and Code Listing

    DTIC Science & Technology

    1988-07-01

    AAM) AT ALL Y LEVELS WRITE(NOUT) (AAM(I).I=1, NRAMP ) 00 150 J=1.NV 150 WRITE(NUOUT) (AYM(I .J) ,I11, NRAMP ) IF(IDBLJG2.NE.0) THIEN WRITEC6. 1038) CALL...COMPUTATIONS C C SAVE THE COMPuILO AMP’ ITubES C WRITE(NUOUT) (WERK(I) ,I I, NRAMP ) WRITE(NUOUT) (AAM) I), I1 , NRAMP ) WRITE (NUOUT) (AAP (I) .I=1. NRAMP ) DO...450 J=1,NY 450 wRITE(NuOUT) (A\\’M(I ,.),Iz.1, NRAMP ) 00 451 j=l.Ny 451 vyRITE NjOUT) (AYPL(I .j),I 1,NkAMP) ENDFILE NUOUT IF(IDBUG2.NE.(ni T,-EN WRITE

  6. Some Problems of Heat Transfer in Rockets

    DTIC Science & Technology

    1946-05-01

    Pag« List of symbols ••••• rit Abstract • 1 Part I. INTRODUCTION 1 II. BEAT TRANSFER TO THE -..’ALLS OF THE BURSTER TUBE 3 III. EFFECT...fc. ,V2 2/t 1/8 Laplace operator, (J*0z*) t (daA9ys) t 0’/9z"). Thermal conductivity (cal/cm-sec-°C). Density of gas [ Part IZ] or density of TNT... Part IV] (gm/cm*). ^- (a’oA)D. •- (rj c/*)D. vUi SCME PROBLEMS OF BUT TRANSFER II ROCKETS Abstract Seme of the problem« ooanootod «1th tte

  7. The Effects of information barrier requirements on the trilateral initiative attribute measurement system (AVNG).

    SciTech Connect

    MacArthur, D. W.; Langner, D. C.; Whiteson, R.; Wolford, J. K.

    2001-01-01

    Although the detection techniques used for measuring classified materials are very similar to those used in unclassified measurements, the surrounding packaging is generally very different. If iZ classified item is to be measured, an information barrier is required to protect any classified data acquired. This information barrier must protect the classified information while giving the inspector confidence that the unclassified outputs accurately reflect the classified inputs, Both information barrier and authentication considerations must be considered during all phases of system design and fabrication. One example of such a measurement system is the attribute measurement system (termed the AVNG) designed for the: Trilateral Initiative. We will discuss the integration of information barrier components into this system as well as the effects of an information barrier (including authentication) concerns on the implementation of the detector systems.

  8. [Inhibition of NF-kB Activation Decreases Resistance in Acute Myeloid Leukemia Cells to TRAIL-induced Apoptosis in Multicellular Aggregates].

    PubMed

    Fadeev, R S; Solovieva, M E; Slyadovskiy, D A; Zakharov, S G; Fadeeva, I S; Senotov, A S; Golenkov, A K; Akatov, V S

    2015-01-01

    Suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates, was studied using small molecule inhibitors of the activation of the transcription factor NF-kB - NF-k9 Activation Inhibitor IV and JSH-23 at non-toxic concentrations. NF-kB Activation Inhibitor IV and JSH-23 reduced resistance in the acute myeloid leukemia cells in multicellular aggregates to cytotoxic action of recombinant protein izTRAIL. It is shown that the use of these inhibitors decreased the phosphorylation of the RelA (p65) as a main marker activation of the transcription factor NF-kB. We discuss a possible reason for increasing resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates.

  9. [The biological properties of the HIV isolated from a virus carrier living in the Byelorussian SSR].

    PubMed

    Rytik, P G; van der Groen, G; Eremin, V F; Kolomiets, N D; Popov, S A; Nijs, P; Willems, V; Verkauteren, G; Il'kevich, Iu G; Lemeshko, N N

    1990-01-01

    Biological properties of an AIDS agent first isolated from a native citizen in the USSR are presented. The source of the virus was a young Byelorussian woman who in the near past had had sexual contacts with a citizen from one of the Central Africa countries. The isolate is thought to be of HIV-I type. It replicated perfectly in many continuous lymphocyte lines and had HIV-characteristic morphology. The protein spectrum of the isolate was gp120, gp41, p65/51, p55, p32, p24, p17. Reverse transcriptase activity was detected in the culture fluid of the virus-containing cell cultures. The isolate was designated HIV-IZ.

  10. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 16 (Panhandle Food Sales-Ray Gene Electric Co Inc)

    DTIC Science & Technology

    1990-01-01

    AD-A236 466 1990 ANNUAL PRIME CONTRACTS AWARDS ALPHABETICALLY BY CONTRACTOR, BY STATE OR COUNTRY, AND PLACE. PT-16 (PANHANDLE FOOD SALES-RAY GENE ...4 I-l e~ I 0 MM 0)1 47470:14710) 0) 0) 0) I" gene , I LA 4 00 0) co -4 -FF- F- C (D <r- 0CD I~ gene , U0 -4 0. C4 0> 0D-4-4-40 C> C- N0 -4 (n L-4 cn...LW ,U ’L a) I CIme 𔃺" 0)0)100)0)10)0) (00 0 Ei(Cn" cc cc c c c c c c c c c 410mc’ " ::U. C 001. C00 r-0C0C r00 C w izI0’ M" ~ 000000 , . > .0 000 s-s

  11. The CMC/3DPNS computer program for prediction of three-dimensional, subsonic, turbulent aerodynamic juncture region flow. Volume 3: Programmers' manual

    NASA Technical Reports Server (NTRS)

    Orzechowski, J. A.

    1982-01-01

    The CMC fluid mechanics program system was developed to transmit the theoretical evolution of finite element numerical solution methodology, applied to nonlinear field problems into a versatile computer code for comprehensive flow field analysis. A detailed view of the code from the standpoint of a computer programmer's use is presented. A system macroflow chart and detailed flow charts of several routines necessary to interact with a theoretican/user to modify the operation of this program are presented. All subroutines and details of usage, primarily for input and output routines are described. Integer and real scalars and a cross reference list denoting subroutine usage for these scalars are outlined. Entry points in dynamic storage vector IZ; the lengths of each vector accompanying the scalar definitions are described. A listing of the routines peculiar to the standard test case and a listing of the input deck and printout for this case are included.

  12. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Sets Technology Inc. - System/Technology Development). Part 17

    DTIC Science & Technology

    1994-03-01

    4) c?) 0 n (4) en)(4) 4)(4) 0)(𔃽() 0.-4 ONw .4Nw -4..-4 4 4-4.4 *4 In 0 q *3r. ZZI- 0% NCf) .4N a W) 4O00.(%th U 9 Lai- UI o logo < iz z O Li J U• 0...Cl c 0 CV) 0 0 IC I g0ooyN 14C ZnenviP.P Kfc )UNCqV)S(N (nC Y V)4W0 z GoI.- cc 0 I- 0 I- Cg00I- UIO N (0oo N of ( .. 4VCr) en)en 04)U4 v0.. .-n0inA4O 0

  13. SPITZER TRANSITS OF THE SUPER-EARTH GJ1214b AND IMPLICATIONS FOR ITS ATMOSPHERE

    SciTech Connect

    Fraine, Jonathan D.; Deming, Drake; Gillon, Michaeel; Jehin, Emmanueel; Demory, Brice-Olivier; Benneke, Bjoern; Seager, Sara; Lewis, Nikole K.; Knutson, Heather; Desert, Jean-Michel

    2013-03-10

    We observed the transiting super-Earth exoplanet GJ1214b using warm Spitzer at 4.5 {mu}m wavelength during a 20 day quasi-continuous sequence in 2011 May. The goals of our long observation were to accurately define the infrared transit radius of this nearby super-Earth, to search for the secondary eclipse, and to search for other transiting planets in the habitable zone of GJ1214. We here report results from the transit monitoring of GJ1214b, including a reanalysis of previous transit observations by Desert et al. In total, we analyze 14 transits of GJ1214b at 4.5 {mu}m, 3 transits at 3.6 {mu}m, and 7 new ground-based transits in the I+z band. Our new Spitzer data by themselves eliminate cloudless solar composition atmospheres for GJ1214b, and methane-rich models from Howe and Burrows. Using our new Spitzer measurements to anchor the observed transit radii of GJ1214b at long wavelengths, and adding new measurements in I+z, we evaluate models from Benneke and Seager and Howe and Burrows using a {chi}{sup 2} analysis. We find that the best-fit model exhibits an increase in transit radius at short wavelengths due to Rayleigh scattering. Pure water atmospheres are also possible. However, a flat line (no atmosphere detected) remains among the best of the statistically acceptable models, and better than pure water atmospheres. We explore the effect of systematic differences among results from different observational groups, and we find that the Howe and Burrows tholin-haze model remains the best fit, even when systematic differences among observers are considered.

  14. Growth trajectories of the human fetal brain tissues estimated from 3D reconstructed in utero MRI.

    PubMed

    Scott, Julia A; Habas, Piotr A; Kim, Kio; Rajagopalan, Vidya; Hamzelou, Kia S; Corbett-Detig, James M; Barkovich, A James; Glenn, Orit A; Studholme, Colin

    2011-08-01

    In the latter half of gestation (20-40 gestational weeks), human brain growth accelerates in conjunction with cortical folding and the deceleration of ventricular zone progenitor cell proliferation. These processes are reflected in changes in the volume of respective fetal tissue zones. Thus far, growth trajectories of the fetal tissue zones have been extracted primarily from 2D measurements on histological sections and magnetic resonance imaging (MRI). In this study, the volumes of major fetal zones-cortical plate (CP), subplate and intermediate zone (SP+IZ), germinal matrix (GMAT), deep gray nuclei (DG), and ventricles (VENT)--are calculated from automatic segmentation of motion-corrected, 3D reconstructed MRI. We analyzed 48 T2-weighted MRI scans from 39 normally developing fetuses in utero between 20.57 and 31.14 gestational weeks (GW). The supratentorial volume (STV) increased linearly at a rate of 15.22% per week. The SP+IZ (14.75% per week) and DG (15.56% per week) volumes increased at similar rates. The CP increased at a greater relative rate (18.00% per week), while the VENT (9.18% per week) changed more slowly. Therefore, CP increased as a fraction of STV and the VENT fraction declined. The total GMAT volume slightly increased then decreased after 25 GW. We did not detect volumetric sexual dimorphisms or total hemispheric volume asymmetries, which may emerge later in gestation. Further application of the automated fetal brain segmentation to later gestational ages will bridge the gap between volumetric studies of premature brain development and normal brain development in utero. Published by Elsevier Ltd.

  15. Growth trajectories of the human fetal brain tissues estimated from 3D reconstructed in utero MRI

    PubMed Central

    Scott, Julia A.; Habas, Piotr A.; Kim, Kio; Rajagopalan, Vidya; Hamzelou, Kia S.; Corbett-Detig, James M.; Barkovich, A. James; Glenn, Orit A.; Studholme, Colin

    2012-01-01

    In the latter half of gestation (20 to 40 gestational weeks), human brain growth accelerates in conjunction with cortical folding and the deceleration of ventricular zone progenitor cell proliferation. These processes are reflected in changes in the volume of respective fetal tissue zones. Thus far, growth trajectories of the fetal tissue zones have been extracted primarily from 2D measurements on histological sections and magnetic resonance imaging (MRI). In this study, the volumes of major fetal zones—cortical plate (CP), subplate and intermediate zone (SP+IZ), germinal matrix (GMAT), deep gray nuclei (DG), and ventricles (VENT)—are calculated from automatic segmentation of motion-corrected, 3D reconstructed MRI. We analyzed 48 T2-weighted MRI scans from 39 normally developing fetuses in utero between 20.57 and 31.14 gestational weeks (GW). The supratentorial volume (STV) increased linearly at a rate of 15.22% per week. The SP+IZ (14.75% per week) and DG (15.56% per week) volumes increased at similar rates. The CP increased at a greater relative rate (18.00% per week), while the VENT (9.18% per week) changed more slowly. Therefore, CP increased as a fraction of STV and the VENT fraction declined. The total GMAT volume slightly increased then decreased after 25 GW. We did not detect volumetric sexual dimorphisms or total hemispheric volume asymmetries, which may emerge later in gestation. Further application of the automated fetal brain segmentation to later gestational ages will bridge the gap between volumetric studies of premature brain development and normal brain development in utero. PMID:21530634

  16. Correlating Photoreceptor Mosaic Structure to Clinical Findings in Stargardt Disease

    PubMed Central

    Razeen, Moataz M.; Cooper, Robert F.; Langlo, Christopher S.; Goldberg, Mara R.; Wilk, Melissa A.; Han, Dennis P.; Connor, Thomas B.; Fishman, Gerald A.; Collison, Frederick T.; Sulai, Yusufu N.; Dubra, Alfredo; Carroll, Joseph; Stepien, Kimberly E.

    2016-01-01

    Purpose To demonstrate a method for correlating photoreceptor mosaic structure with optical coherence tomography (OCT) and microperimetry findings in patients with Stargardt disease. Methods A total of 14 patients with clinically diagnosed Stargardt disease were imaged using confocal and split-detection adaptive optics scanning light ophthalmoscopy. Cone photoreceptors were identified manually in a band along the temporal meridian. Resulting values were compared to a normative database (n = 9) to generate cone density deviation (CDD) maps. Manual measurement of outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness was performed, in addition to determination of the presence of ellipsoid zone (EZ) and interdigitation zone (IZ) bands on OCT. These results, along with microperimetry data, were overlaid with the CDD maps. Results Wide variation in foveal structure and CDD maps was seen within this small group. Disruption of ONL+HFL and/or IZ band was seen in all patients, with EZ band preservation in regions with low cone density in 38% of locations analyzed. Normality of retinal lamellar structure on OCT corresponded with cone density and visual function at 50/78 locations analyzed. Outer retinal tubulations containing photoreceptor-like structures were observed in 3 patients. Conclusions The use of CDD color-coded maps enables direct comparison of cone mosaic local density with other measures of retinal structure and function. Larger normative datasets and improved tools for automation of image alignment are needed. Translational Relevance The approach described facilitates comparison of complex multimodal data sets from patients with inherited retinal degeneration, and can be expanded to incorporate other structural imaging or functional testing. PMID:26981328

  17. Feasibility of Affibody-Based Bioorthogonal Chemistry-Mediated Radionuclide Pretargeting.

    PubMed

    Altai, Mohamed; Perols, Anna; Tsourma, Maria; Mitran, Bogdan; Honarvar, Hadis; Robillard, Marc; Rossin, Raffaella; ten Hoeve, Wolter; Lubberink, Mark; Orlova, Anna; Karlström, Amelie Eriksson; Tolmachev, Vladimir

    2016-03-01

    Affibody molecules constitute a new class of probes for radionuclide tumor targeting. The small size of Affibody molecules is favorable for rapid localization in tumors and clearance from circulation. However, high renal reabsorption of Affibody molecules prevents the use of residualizing radiometals, including several promising low-energy β- and α-emitters, for radionuclide therapy. We tested a hypothesis that Affibody-based pretargeting mediated by a bioorthogonal interaction between trans-cyclooctene (TCO) and tetrazine would provide higher accumulation of radiometals in tumor xenografts than in the kidneys. TCO was conjugated to the anti-human epidermal growth factor receptor 2 (HER2) Affibody molecule Z2395. DOTA-tetrazine was labeled with (111)In and (177)Lu. In vitro pretargeting was studied in HER2-expressing SKOV-3 and BT474 cell lines. In vivo studies were performed on BALB/C nu/nu mice bearing SKOV-3 xenografts. (125)I-Z2395-TCO bound specifically to HER2-expressing cells in vitro with an affinity of 45 ± 16 pM. (111)In-tetrazine bound specifically and selectively to Z2395-TCO pretreated cells. In vivo studies demonstrated HER2-specific (125)I-Z2395-TCO accumulation in xenografts. TCO-mediated (111)In-tetrazine localization was shown in tumors, when the radiolabeled tracer was injected 4 h after an injection of Z2395-TCO. At 1 h after injection, the tumor uptake of (111)In-tetrazine and (177)Lu-tetrazine was approximately 2-fold higher than the renal uptake. Pretargeting provided more than a 56-fold reduction of renal uptake of (111)In in comparison with direct targeting. The feasibility of Affibody-based bioorthogonal chemistry-mediated pretargeting was demonstrated. The use of pretargeting provides a substantial reduction of radiometal accumulation in kidneys, creating preconditions for palliative radionuclide therapy. © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  18. 3D Thermal Stratification of Koycegiz Lake, Turkey.

    NASA Astrophysics Data System (ADS)

    Gurcan, Tugba; Kurtulus, Bedri; Avsar, Ozgur; Avsar, Ulas

    2017-04-01

    Water temperature in lakes, streams and coastal areas is an important indicator for several purposes (water quality, aquatic organism, land use, etc..). There are over a hundred lakes in Turkey. Most of them locates in the area known as the Lake District in southwestern Turkey. The Study area is located at the south and southwest part of Turkey in Muǧla region. The present study focuses on determining possible thermocline changes in Lake Koyceǧiz by in-situ measurements. The measurement were done by two snapshot campaign at July and August 2013. Using Mugla Sıtkı Kocman University geological engineering floating platform, temperature, specific conductance, salinity and depth values were measured with the YSI 6600 and Horiba U2 devices in surface and depth of Lake Köyceǧiz at specific grid. When the depth of the water and the coordinates were measured by GPS. Scattered data interpolation is used to perform interpolation on a scattered dataset that resides in 3D space. The 3D temperature color mesh grid were generated by using Delaunay triangulation and Natural neighbor interpolation methodology. At the end of the study a 3D conceptual lake temperature dynamics model was reconstructed using MATLAB functions. The results show that Koycegiz Lake is a meromictic lake and has a significance decrease of Temperature at 7m of depth.In this regard, we would like also to thank TUBITAK project (112Y137), French Embassy in Turkey and Sıtkı Kocman Foundation for their financial support.

  19. Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.

    PubMed

    Ohshima, Toshio; Hirasawa, Motoyuki; Tabata, Hidenori; Mutoh, Tetsuji; Adachi, Tomoko; Suzuki, Hiromi; Saruta, Keiko; Iwasato, Takuji; Itohara, Shigeyoshi; Hashimoto, Mistuhiro; Nakajima, Kazunori; Ogawa, Masaharu; Kulkarni, Ashok B; Mikoshiba, Katsuhiko

    2007-06-01

    The mammalian cerebral cortex consists of six layers that are generated via coordinated neuronal migration during the embryonic period. Recent studies identified specific phases of radial migration of cortical neurons. After the final division, neurons transform from a multipolar to a bipolar shape within the subventricular zone-intermediate zone (SVZ-IZ) and then migrate along radial glial fibres. Mice lacking Cdk5 exhibit abnormal corticogenesis owing to neuronal migration defects. When we introduced GFP into migrating neurons at E14.5 by in utero electroporation, we observed migrating neurons in wild-type but not in Cdk5(-/-) embryos after 3-4 days. Introduction of the dominant-negative form of Cdk5 into the wild-type migrating neurons confirmed specific impairment of the multipolar-to-bipolar transition within the SVZ-IZ in a cell-autonomous manner. Cortex-specific Cdk5 conditional knockout mice showed inverted layering of the cerebral cortex and the layer V and callosal neurons, but not layer VI neurons, had severely impaired dendritic morphology. The amount of the dendritic protein Map2 was decreased in the cerebral cortex of Cdk5-deficient mice, and the axonal trajectory of cortical neurons within the cortex was also abnormal. These results indicate that Cdk5 is required for proper multipolar-to-bipolar transition, and a deficiency of Cdk5 results in abnormal morphology of pyramidal neurons. In addition, proper radial neuronal migration generates an inside-out pattern of cerebral cortex formation and normal axonal trajectories of cortical pyramidal neurons.

  20. Age-related changes in the inner zone of the adrenal cortex of the rat--a morphologic and biochemical study.

    PubMed

    de Almeida, H; Magalhães, M C; Magalhães, M M

    1998-09-15

    In this work, a correlative morphologic and biochemical study on the effects of ageing on the rat adrenal Inner Zone (IZ) was made. Male Wistar rats were studied at 2, 6, 12, 18 and 24 months. Structural data of Zona Fasciculata (ZF) showed age-related increase in cell volume (P < 0.05), decrease in mitochondria (P < 0.01) and smooth endoplasmic reticulum (SER) volumes, and increase in lipid droplets (P < 0.01) and lipofuscin granules (P < 0.01) volumes. In Zona Reticularis, the main change observed was the increase in lipofuscin granules (P < 0.001). Serum corticosterone from unstimulated rats increased until 12 months but decreased thereafter (P < 0.01), to levels below those from 2-month-old rats. Similarly, plasma adrenocorticotrophic hormone (ACTH) presented a maximum at 12 months, followed by a decrease to levels higher than at 2 months (P < 0.05). In rats injected either with only ACTH or dexamethasone, before ACTH stimulation, corticosterone level had a maximum at 12 months. In aged rats, serum high density lipoprotein (HDL) and adrenal cholesterol ester increased significantly (P < 0.05 and P < 0.01, respectively), whereas adrenal corticosterone decreased. Products of lipid peroxidation, assayed with the thiobarbituric acid reaction and fluorimetry showed an age-related increase (P < 0.05). The age-related decrease in mitochondria and SER volumes is consistent with the decrease of serum corticosterone. The increase in lipid droplet and HDL and the reduction of adrenal corticosterone level correlate with the increase of adrenal cholesterol ester content. These suggest a continued uptake of steroid precursor but a reduced steroid synthesis. On the whole, the data provide evidence for an age-related reduced functional ability of IZ and particularly of ZF.

  1. Multimodal Imaging of Photoreceptor Structure in Choroideremia

    PubMed Central

    Johnson, Ryan D.; Williams, Vesper; Summerfelt, Phyllis; Dubra, Alfredo; Weinberg, David V.; Stepien, Kimberly E.; Fishman, Gerald A.; Carroll, Joseph

    2016-01-01

    Purpose Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions. Methods Twelve males with clinically-diagnosed choroideremia and confirmed hemizygous mutations in the CHM gene were examined. High-resolution images of the retina were obtained using spectral domain optical coherence tomography (SD-OCT) and both confocal and non-confocal split-detector adaptive optics scanning light ophthalmoscope (AOSLO) techniques. Results Eleven CHM gene mutations (3 novel) were identified; three subjects had the same mutation and one subject had two mutations. SD-OCT findings included interdigitation zone (IZ) attenuation or loss in 10/12 subjects, often in areas with intact ellipsoid zones; RPE thinning in all subjects; interlaminar bridges in the imaged areas of 10/12 subjects; and outer retinal tubulations (ORTs) in 10/12 subjects. Only split-detector AOSLO could reliably resolve cones near lesion borders, and such cones were abnormally heterogeneous in morphology, diameter and density. On split-detector imaging, the cone mosaic terminated sharply at lesion borders in 5/5 cases examined. Split-detector imaging detected remnant cone inner segments within ORTs, which were generally contiguous with a central patch of preserved retina. Conclusions Early IZ dropout and RPE thinning on SD-OCT are consistent with previously published results. Evidence of remnant cone inner segments within ORTs and the continuity of the ORTs with preserved retina suggests that these may represent an intermediate state of retinal degeneration prior to complete atrophy. Taken together, these results supports a model of choroideremia in which the RPE degenerates before photoreceptors. PMID:27936069

  2. Differences in morphology and force/velocity relationship between Senegalese and Italian sprinters.

    PubMed

    Rahmani, Abderrehmane; Locatelli, Elio; Lacour, Jean-Rene

    2004-04-01

    In order to investigate whether the supremacy of African sprinters is related to the leg extensor force/velocity relationship or to leg morphology, two groups of elite sprinters originating respectively from Senegal (S) and Italy (I) were compared in this respect. The groups included 13 S and 15 I male sprinters. Their mean best performances over 100 m during the preceding track and field season were 10.66 (0.3) and 10.61 (0.3) s (NS), respectively. Age, height and mass were similar in the two groups. The force/velocity relationship of the leg extensors was assessed during maximal half-squats on a guided horizontal barbell with masses of 20-140 kg added on the shoulders. Leg morphology was assessed by relating the sub-ischial length to the standing height (L/H) and by measuring the inertia in the vertical (IZ in kg.cm2), antero-posterior (IY, kg.cm2) and medio-lateral (IX, kg.m2) planes. The two groups developed non-different force and power when lifting the heaviest loads. Inversely, the lighter the load, the lower the force and power developed by S, as compared to I (P<0.001). S demonstrated greater L/H (P<0.001), and 26% lower IZ (P<0.01), 15% lower IY (P=0.09), and 14% lower IX (P=0.10). These results suggest that S and I sprinters were similar as regards the muscle abilities involved in slow maximal contractions. However, S demonstrated lower values in muscle abilities related to high-speed contractions, suggesting that S sprinters had a lower percentage of fast twitch fibres. This is likely to be compensated for by the lower level of internal work due to longer and lighter legs.

  3. DNA damage by the sulfate radical anion: hydrogen abstraction from the sugar moiety versus one-electron oxidation of guanine.

    PubMed

    Roginskaya, Marina; Mohseni, Reza; Ampadu-Boateng, Derrick; Razskazovskiy, Yuriy

    2016-07-01

    The products of oxidative damage to double-stranded (ds) DNA initiated by photolytically generated sulfate radical anions SO4(•-) were analyzed using reverse-phase (RP) high-performance liquid chromatography (HPLC). Relative efficiencies of two major pathways were compared: production of 8-oxoguanine (8oxoG) and hydrogen abstraction from the DNA 2-deoxyribose moiety (dR) at C1,' C4,' and C5' positions. The formation of 8oxoG was found to account for 87% of all quantified lesions at low illumination doses. The concentration of 8oxoG quickly reaches a steady state at about one 8oxoG per 100 base pairs due to further oxidation of its products. It was found that another guanine oxidation product identified as 2-amino-5-(2'-alkylamino)-4H-imidazol-4-one (X) was released in significant quantities from its tentative precursor 2-amino-5-[(2'-deoxy-β-d-erythro-pentofuranosyl)amino]-4H-imidazol-4-one (dIz) upon treatment with primary amines in neutral solutions. The linear dose dependence of X release points to the formation of dIz directly from guanine and not through oxidation of 8oxoG. The damage to dR was found to account for about 13% of the total damage, with majority of lesions (33%) originating from the C4' oxidation. The contribution of C1' oxidation also turned out to be significant (17% of all dR damages) despite of the steric problems associated with the abstraction of the C1'-hydrogen. However, no evidence of base-to-sugar free valence transfer as a possible alternative to direct hydrogen abstraction at C1' was found.

  4. Continuous-flow laboratory simulation of stream water quality changes downstream of an untreated wastewater discharge.

    PubMed

    Finnegan, C J; van Egmond, R A; Price, O R; Whelan, M J

    2009-04-01

    In regions of the world with poor provision of wastewater treatment, raw sewage is often discharged directly into surface waters. This paper describes an experimental evaluation of the fate of two organic chemicals under these conditions using an artificial channel cascade fed with a mix of settled sewage and river water at its upstream end and operated under continuous steady-state conditions. The experiments underpin an environmental risk assessment methodology based on the idea of an "impact zone" (IZ) - the zone downstream of wastewater emission in which water quality is severely impaired by high concentrations of unionised ammonia, nitrite and biochemical oxygen demand (BOD). Radiolabelled dodecane-6-benzene sulphonate (DOBS) and aniline hydrochloride were used as the model chemical and reference compound respectively. Rapid changes in (14)C counts were observed with flow-time for both these materials. These changes were most likely to be due to complete mineralisation. A dissipation half-life of approximately 7.1 h was observed for the (14)C label with DOBS. The end of the IZ was defined as the point at which the concentration of both unionised ammonia and nitrite fell below their respective predicted no-effect concentrations for salmonids. At these points in the cascade, approximately 83 and 90% of the initial concentration of (14)C had been removed from the water column, respectively. A simple model of mineral nitrogen transformations based on Michaelis-Menten kinetics was fitted to observed concentrations of NH(4), NO(2) and NO(3). The cascade is intended to provide a confirmatory methodology for assessing the ecological risks of chemicals under direct discharge conditions.

  5. Mass flows of perfluorinated compounds (PFCs) in central wastewater treatment plants of industrial zones in Thailand.

    PubMed

    Kunacheva, Chinagarn; Tanaka, Shuhei; Fujii, Shigeo; Boontanon, Suwanna Kitpati; Musirat, Chanatip; Wongwattana, Thana; Shivakoti, Binaya Raj

    2011-04-01

    Perfluorinated compounds (PFCs) are fully fluorinated organic compounds, which have been used in many industrial processes and have been detected in wastewater and sludge from municipal wastewater treatment plants (WWTPs) around the world. This study focused on the occurrences of PFCs and PFCs mass flows in the industrial wastewater treatment plants, which reported to be the important sources of PFCs. Surveys were conducted in central wastewater treatment plant in two industrial zones in Thailand. Samples were collected from influent, aeration tank, secondary clarifier effluent, effluent and sludge. The major purpose of this field study was to identify PFCs occurrences and mass flow during industrial WWTP. Solid-phase extraction (SPE) coupled with HPLC-ESI-MS/MS were used for the analysis. Total 10 PFCs including perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluoropropanoic acid (PFPA), perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), perfluorohexane sulfonate (PFHxS), perfluoronanoic acid (PFNA), perfluordecanoic acid (PFDA), perfluoroundecanoic acid (PFUnA), and perfluorododecanoic acid (PFDoA) were measured to identify their occurrences. PFCs were detected in both liquid and solid phase in most samples. The exceptionally high level of PFCs was detected in the treatment plant of IZ1 and IZ2 ranging between 662-847ngL(-1) and 674-1383ngL(-1), respectively, which greater than PFCs found in most domestic wastewater. Due to PFCs non-biodegradable property, both WWTPs were found ineffective in removing PFCs using activated sludge processes. Bio-accumulation in sludge could be the major removal mechanism of PFCs in the process. The increasing amount of PFCs after activated sludge processes were identified which could be due to the degradation of PFCs precursors. PFCs concentration found in the effluent were very high comparing to those in river water of the area. Industrial activity could be the one of major sources of PFCs

  6. High Ionization Species in the Nearby Interstellar Medium from an Exhaustive Analysis of the IUE INES Database

    NASA Astrophysics Data System (ADS)

    Freire Ferrero, R.; Morales Durán, C.; Halbwachs, J.-L.; Cabo Cubeiro, A. M.

    2012-02-01

    Main-sequence (MS) and giant late-B and early-A type stars are the best targets for searching for nearby interstellar (IS) Si IV and C IV resonance lines because they are not able to produce them, either in atmospheric layers or in their circumstellar environment, and because many stars of these spectral types are nearby and located in the local interstellar medium (LISM). In addition, the use of certain stars hotter than B6 can lead to misinterpretations (e.g., alpha Arae). This work analyzes the reliable Short-Wavelength Prime high-resolution UV spectra of 558 B6-A9 type stars observed by the International Ultraviolet Explorer at distances lower than 400 pc from the Sun. For the first time, this work utilizes the entire INES database to extract stellar and IS information in a systematic way from homogeneous data. Stars were classified into seven groups: normal (MS and subgiant), giant, peculiar, emission line, Algols, pre-main sequence or Herbig Ae/Be, and shell stars. Only 10 normal stars, located beyond 90 pc, show weak Si IV and C IV absorptions and are clustered around the direction of Sco-Cen, while 85 located closer than 90 pc, as well as another 89 beyond 90 pc, do not show any absorptions at all. We conclude that these highly ionized species originate most probably in the LISM, at 90 pc from the Sun, corresponding to the warm interaction zone (IZ), where the expanding Loop I super-shell and the Local Bubble collide. We base our results on a robust statistical analysis of both spectral types and spatial distributions of the different stellar groups we defined. Our estimated column densities N of both ions are similar to those obtained by other authors for distant stars, suggesting that these absorptions concentrate fundamentally in the IZ. A logarithmic correlation between N and the distance D confirms these results.

  7. HIGH IONIZATION SPECIES IN THE NEARBY INTERSTELLAR MEDIUM FROM AN EXHAUSTIVE ANALYSIS OF THE IUE INES DATABASE

    SciTech Connect

    Freire Ferrero, R.; Halbwachs, J.-L.; Morales Duran, C.; Cabo Cubeiro, A. M. E-mail: jean-louis.halbwachs@astro.unistra.fr E-mail: amcabo@cab.inta-csic.es

    2012-02-15

    Main-sequence (MS) and giant late-B and early-A type stars are the best targets for searching for nearby interstellar (IS) Si IV and C IV resonance lines because they are not able to produce them, either in atmospheric layers or in their circumstellar environment, and because many stars of these spectral types are nearby and located in the local interstellar medium (LISM). In addition, the use of certain stars hotter than B6 can lead to misinterpretations (e.g., alpha Arae). This work analyzes the reliable Short-Wavelength Prime high-resolution UV spectra of 558 B6-A9 type stars observed by the International Ultraviolet Explorer at distances lower than 400 pc from the Sun. For the first time, this work utilizes the entire INES database to extract stellar and IS information in a systematic way from homogeneous data. Stars were classified into seven groups: normal (MS and subgiant), giant, peculiar, emission line, Algols, pre-main sequence or Herbig Ae/Be, and shell stars. Only 10 normal stars, located beyond 90 pc, show weak Si IV and C IV absorptions and are clustered around the direction of Sco-Cen, while 85 located closer than 90 pc, as well as another 89 beyond 90 pc, do not show any absorptions at all. We conclude that these highly ionized species originate most probably in the LISM, at 90 pc from the Sun, corresponding to the warm interaction zone (IZ), where the expanding Loop I super-shell and the Local Bubble collide. We base our results on a robust statistical analysis of both spectral types and spatial distributions of the different stellar groups we defined. Our estimated column densities N of both ions are similar to those obtained by other authors for distant stars, suggesting that these absorptions concentrate fundamentally in the IZ. A logarithmic correlation between N and the distance D confirms these results.

  8. Chemical Composition and In Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil from the Tunisian Endemic Ferula tunetana Pomel ex Batt.

    PubMed

    Znati, Mansour; Filali, Insaf; Jabrane, Aymen; Casanova, Joseph; Bouajila, Jalloul; Ben Jannet, Hichem

    2017-01-01

    Essential oil of the seeds from the endemic Tunisian plant Ferula tunetana Pomel ex Batt. was analyzed for its chemical composition and screened for its antimicrobial, antioxidant and antigerminative properties. The chemical composition of the isolated oil is reported for the first time. According to the GC/FID, GC/MS and (13) C-NMR analysis results; 18 compounds were identified accounting for 84.6% of the total oil. The chemical composition of this essential oil was characterized by the presence of a high proportion of monoterpene hydrocarbons (77.3%) followed by oxygenated sesquiterpenes (4.1%) and sesquiterpene hydrocarbons (3.2%). α-Pinene (39.8%), β-pinene (11.5%) and (Z)-β-ocimene (7.5%) were the predominant compounds. Moreover, the isolated oil was tested for its antimicrobial activity using the disc-diffusion and the microdilution assays against six Gram-positive and five Gram-negative bacteria as well as towards two Candida species. The isolated oil was tested also for its antioxidant activity against DPPH, ABTS, O2∙ and hydrogen peroxide (H2 O2 ), and for its antigerminative potential. It was found that it exhibited interesting antimicrobial activity against Salmonella typhimurium LT2 DT104 (inhibition zone (IZ) 16.2 ± 1.0 mm) and Bacillus cereus ATCC 14579 (IZ 15.8 ± 1.0 mm). However, it exerted a moderate antioxidant activity against H2 O2 (IC50 78.2 ± 2.98 μg/ml) and towards O2∙ (IC50 89.2 ± 3.82 μg/ml). The antigerminative effect of this oil was also evaluated in this work. Results showed a toxic effect.

  9. Adaptation of all-ceramic fixed partial dentures

    PubMed Central

    Borba, Márcia; Cesar, Paulo F.; Griggs, Jason A.; Della Bona, Álvaro

    2011-01-01

    Objectives To measure the marginal and internal fit of three-unit fixed partial dentures (FPDs) using the micro-CT technique, testing the null hypothesis that there is no difference in the adaptation between the ceramic systems studied. Methods Stainless steel models of prepared abutments were fabricated to design the FPDs. Ten FPDs were produced from each framework ceramic (YZ - Vita In-Ceram YZ and IZ - Vita In-Ceram Zirconia) using CEREC inLab according to the manufacturer instructions. All FPDs were veneered using the recommended porcelain. Each FPD was seated on the original model and scanned using micro-CT. Files were processed using NRecon and CTAn software. Adobe Photoshop and Image J software were used to analyze the cross-sections images. Five measuring locations were used as follows: MG – marginal gap; CA - chamfer area; AW - axial wall; AOT - axio-occlusal transition area; OA - occlusal area. The horizontal marginal discrepancy (HMD) was evaluated in another set of images. Results were statistically analyzed using ANOVA and Tukey tests (α=0.05). Results The mean values for MG, CA, AW, OA and HMD were significantly different for all tested groups (p<0.05). IZ exhibited greater mean values than YZ for all measuring locations except for AW and AOT. OA showed the greatest mean gap values for both ceramic systems. MG and AW mean gap values were low for both systems. Significance The ceramic systems evaluated showed different levels of marginal and internal fit, rejecting the study hypothesis. Yet, both ceramic systems showed clinically acceptable marginal and internal fit. PMID:21920595

  10. Flexural strength of glass-infiltrated zirconia/alumina-based ceramics and feldspathic veneering porcelains.

    PubMed

    Bottino, Marco Antonio; Salazar-Marocho, Susana M; Leite, Fabiola P P; Vásquez, Vanessa C; Valandro, Luiz Felipe

    2009-07-01

    To compare the flexural strength of two glass-infiltrated high-strength ceramics and two veneering glass-ceramics. Four ceramic materials were tested: two glass-infiltrated high-strength ceramics used as framework in metal-free restorations [In-Ceram Zirconia IZ (Gr1) and In-Ceram Alumina IA (Gr2)], and two glass-ceramics used as veneering material in metal-free restorations [Vita VM7 (Gr3) and Vitadur-alpha (Gr4)]. Bar specimens (25 x 5 x 2 mm3) made from core ceramics, alumina, and zirconia/alumina composites were prepared and applied to a silicone mold, which rested on a base from a gypsum die material. The IZ and IA specimens were partially sintered in an In-Ceram furnace according to the firing cycle of each material, and then were infiltrated with a low-viscosity glass to yield bar specimens of high density and strength. The Vita VM7 and Vitadur-alpha specimens were made from veneering materials, by vibration of slurry porcelain powder and condensation into a two-part brass Teflon matrix (25 x 5 x 2 mm3). Excess water was removed with absorbent paper. The veneering ceramic specimens were then removed from the matrix and were fired as recommended by the manufacturer. Another ceramic application and sintering were performed to compensate the contraction of the feldspar ceramic. The bar specimens were then tested in a three-point bending test. The core materials (Gr1: 436.1 +/- 54.8; Gr2: 419.4 +/- 83.8) presented significantly higher flexural strength (MPa) than the veneer ceramics (Gr3: 63.5 +/- 9.9; Gr4: 57.8 +/- 12.7). In-Ceram Alumina and Zirconia were similar statistically and more resistant than VM7 and Vitadur-alpha.

  11. Monoamine Release in the Cat Lumbar Spinal Cord during Fictive Locomotion Evoked by the Mesencephalic Locomotor Region.

    PubMed

    Noga, Brian R; Turkson, Riza P; Xie, Songtao; Taberner, Annette; Pinzon, Alberto; Hentall, Ian D

    2017-01-01

    Spinal cord neurons active during locomotion are innervated by descending axons that release the monoamines serotonin (5-HT) and norepinephrine (NE) and these neurons express monoaminergic receptor subtypes implicated in the control of locomotion. The timing, level and spinal locations of release of these two substances during centrally-generated locomotor activity should therefore be critical to this control. These variables were measured in real time by fast-cyclic voltammetry in the decerebrate cat's lumbar spinal cord during fictive locomotion, which was evoked by electrical stimulation of the mesencephalic locomotor region (MLR) and registered as integrated activity in bilateral peripheral nerves to hindlimb muscles. Monoamine release was observed in dorsal horn (DH), intermediate zone/ventral horn (IZ/VH) and adjacent white matter (WM) during evoked locomotion. Extracellular peak levels (all sites) increased above baseline by 138 ± 232.5 nM and 35.6 ± 94.4 nM (mean ± SD) for NE and 5-HT, respectively. For both substances, release usually began prior to the onset of locomotion typically earliest in the IZ/VH and peaks were positively correlated with net activity in peripheral nerves. Monoamine levels gradually returned to baseline levels or below at the end of stimulation in most trials. Monoamine oxidase and uptake inhibitors increased the release magnitude, time-to-peak (TTP) and decline-to-baseline. These results demonstrate that spinal monoamine release is modulated on a timescale of seconds, in tandem with centrally-generated locomotion and indicate that MLR-evoked locomotor activity involves concurrent activation of descending monoaminergic and reticulospinal pathways. These gradual changes in space and time of monoamine concentrations high enough to strongly activate various receptors subtypes on locomotor activated neurons further suggest that during MLR-evoked locomotion, monoamine action is, in part, mediated by extrasynaptic neurotransmission in

  12. The in Vitro Antibacterial Efficacy of Persian Green Tea Extract as an Intracanal Irrigant on Enterococcus faecalis Biofilm

    PubMed Central

    Ramezanali, Fatemeh; Samimi, Shiva; Kharazifard, Mohammadjavad; Afkhami, Farzaneh

    2016-01-01

    Introduction: The aim of this study was to compare the antibacterial effect of Persian green tea extract (GTE) and 2.5% sodium hypochlorite (NaOCl) against Enterococcus faecalis (E. faecalis) as an intracanal irrigant. Methods and Materials: Thirty freshly extracted teeth were instrumented and sectioned into mesial and distal segments. The specimens were put into wells containing 2 mL of E. faecalis-containing medium. After 3 weeks, the specimens were removed and divided randomly into three groups (n=20). Each group was exposed to 3 mL of different irrigants for 3 min. Groups 1, 2 and 3 were irrigated with GTE, 2.5% NaOCl and normal saline, respectively. Biofilm formed in the middle third of the root canal was carved by sterile scalpel and cultured in Mueller-Hinton medium. Number of colony forming units (CFU) was counted on each plate. In addition, antimicrobial activity of the irrigants was evaluated by the agar disc diffusion test. The diameter of inhibition zone (IZ) around each irrigant was evaluated. The Kruskal-Wallis and Dunn tests were used to analysis the data. Results: While in NaOCl group no bacterial colonies were observed, the mean number of E. faecalis in GTE and control groups were 275±74 CFU/mL (P<0.001) and 119×108±11×108 (P<0.001), respectively. The mean of IZ in NaOCl and GTE groups were 24.35±0.78 and 6.9±0.87 mm, in order of appearance (P<0.001). Zone of inhibition was not observed around the control group (P<0.001). Conclusion: This research highlighted the potential role of plant extracts in antimicrobial root canal irrigation protocol. PMID:27790260

  13. Determination of retinal chromophore structure in bacteriorhodopsin with resonance Raman spectroscopy.

    PubMed

    Smith, S O; Lugtenburg, J; Mathies, R A

    1985-01-01

    The analysis of the vibrational spectrum of the retinal chromophore in bacteriorhodopsin with isotopic derivatives provides a powerful "structural dictionary" for the translation of vibrational frequencies and intensities into structural information. Of importance for the proton-pumping mechanism is the unambiguous determination of the configuration about the C13=C14 and C=N bonds, and the protonation state of the Schiff base nitrogen. Vibrational studies have shown that in light-adapted BR568 the Schiff base nitrogen is protonated and both the C13=C14 and C=N bonds are in a trans geometry. The formation of K625 involves the photochemical isomerization about only the C13=C14 bond which displaces the Schiff base proton into a different protein environment. Subsequent Schiff base deprotonation produces the M412 intermediate. Thermal reisomerization of the C13=C14 bond and reprotonation of the Schiff base occur in the M412------O640 transition, resetting the proton-pumping mechanism. The vibrational spectra can also be used to examine the conformation about the C--C single bonds. The frequency of the C14--C15 stretching vibration in BR568, K625, L550 and O640 argues that the C14--C15 conformation in these intermediates is s-trans. Conformational distortions of the chromophore have been identified in K625 and O640 through the observation of intense hydrogen out-of-plane wagging vibrations in the Raman spectra (see Fig. 2). These two intermediates are the direct products of chromophore isomerization. Thus it appears that following isomerization in a tight protein binding pocket, the chromophore cannot easily relax to a planar geometry. The analogous observation of intense hydrogen out-of-plane modes in the primary photoproduct in vision (Eyring et al., 1982) suggests that this may be a general phenomenon in protein-bound isomerizations. Future resonance Raman studies should provide even more details on how bacterio-opsin and retinal act in concert to produce an

  14. Synthesis, structure, spectral properties and DFT quantum chemical calculations of 4-aminoazobenzene dyes. Effect of intramolecular hydrogen bonding on photoisomerization

    NASA Astrophysics Data System (ADS)

    Georgiev, Anton; Bubev, Emil; Dimov, Deyan; Yancheva, Denitsa; Zhivkov, Ivaylo; Krajčovič, Jozef; Vala, Martin; Weiter, Martin; Machkova, Maria

    2017-03-01

    In this paper three different "push-pull" 4-aminoazobenzene dyes have been synthesized in order to characterize their photochromic behavior in different solvents. The molecular geometry was optimized by DFT/B3LYP functional combined with the standard 6-31 + G(d,p) basis set for trans (E) and cis (Z) isomers and the energy levels of HOMO and LUMO frontier orbitals were computed using IEFPCM solvation in CHCl3 and DMF. The calculated results were compared to the experimental optical band gap and HOMO values of cyclic voltammetry. The intramolecular six-membered hydrogen bond was formed in both isomers of the synthesized dyes. The thermodynamic parameters such as total electronic energy E (RB3LYP), enthalpy H298 (sum of electronic and thermal enthalpies), free Gibbs energy G298 (sum of electronic and thermal free Gibbs energies) and dipole moment μ were computed for trans (E) and cis (Z) isomers in order to estimate the ΔEtrans → cis, Δμtrans → cis, ΔHtrans → cis, ΔGtrans → cis and ΔStrans → cis values. The NBO analysis was performed in order to understand the intramolecular charge transfer and energy of resonance stabilization. The solvatochromic shift was evaluated by UV-VIS spectroscopy in CHCl3 (nonpolar), EtOH (polar protic) and DMF (polar aprotic) solvents to determine the electron withdrawing and donating properties of the substituents on electron transitions energy. Through the increasing solvent polarity a strong bathochromic shift is observed. The photoisomerization experiments have been performed in two solvents CHCl3 (nonpolar) and DMF (polar aprotic) by UV light irradiation with λ = 365 nm at equal concentrations and time of illuminations. The electronic spectra were computed by TD-DFT after geometry optimization using IEFPCM solvation in CHCl3 and DMF. The degree of photoisomerization was calculated for the three azo chromophores in both solvents. By using first derivative of the UV-VIS spectra it was possible to resolve the overlapped

  15. Solvent/solute Interactions Probed by Picosecond Transient Raman Spectroscopy: a Study of S(1) 1,4-DIPHENYL -1,3-BUTADIENE and its Structural Analogues

    NASA Astrophysics Data System (ADS)

    Morris, Daniel Lamon, Jr.

    1995-01-01

    Many important chemical/biochemical reactions involve a short-lived photochemical intermediate. From a practical standpoint, understanding the behavior of such a transient species would allow effective manipulation of many chemical and biochemical processes. In this study, Raman spectroscopy on a picosecond time scale is used to examine the character of the S_1 states of several simple probe molecules and the effect(s) that different solvents have on the behavior of the excited state species in solution. We present the S_1 Raman spectra of 1,4-diphenyl-1,3-butadiene (DPB) in the series of linear alkanes pentane, hexane, heptane, octane, decane, and dodecane. DPB has virtually degenerate electronic states in the vicinity of S_1 (2 ^1A_{rm g} and 1^1B _{rm u}). The electronic state probed by the transient Raman measurements exhibits both 2^1A_{ rm g} and 1^1B _{rm u} character (i.e. a "mixed" state). It appears that a state exhibiting more 2^1A_{ rm g} character is favored by more viscous solvents while a state of significant 1^1 B_{rm u} character is preferred by less viscous solvents. We also observe very broad features (>50 cm ^{-1}) in the S_1 Raman spectra that are associated with motions of the butadiene portion of the molecule. In order to verify that these broad bands arise from a distribution of s-trans conformers in DPB, we have obtained the transient Raman spectra of 1,4-diphenyl-1,3 - cyclopentadiene (DPCP), a "stiff" analogue of DPB. As predicted, the DPCP spectra contain only sharp bands. We also provide evidence for assigning the lowest excited singlet state of DPCP in solution as the 1B state. We evaluate the effect of geometrical constraints on the photophysics of DPCP by obtaining the S _1 Raman spectra of 1,2,3,4-tetraphenyl-1,3 -cyclopentadiene (TPCP) in solution. The addition of the extra phenyl rings to DPCP forces the molecule to take on a non-planar geometry. We confirm that the viscosity -dependent S_1 lifetime of TPCP is due to a

  16. TiCl4-promoted Baylis-Hillman reaction: mechanistic rationale toward product distribution and stereoselectivity.

    PubMed

    Patel, Chandan; Sunoj, Raghavan B

    2010-01-15

    The mechanism of TiCl(4)-promoted Baylis-Hillman reaction between methyl vinyl ketone (MVK) and acetaldehyde, in the absence of any base, is studied using the mPW1K density functional theory. The study focuses on several mechanistic intricacies as well as selectivity issues at each step of the reaction. The minimum energy pathway for this reaction involves three major steps such as a chloride transfer resulting in a chloro-enolate, titanium-mediated aldol reaction, and elimination of HCl or HOTiCl(3). Both s-cis and s-trans conformers of MVK are considered along with various modes of chloride transfer involving different complexes between TiCl(4), aldehyde, and MVK. Chloride transfer is found to be kinetically more favored for s-cis-MVK than for s-trans-MVK. The diastereoselectivity in the next step, i.e., Ti-mediated aldol reaction between the enolate and aldehyde, is found to be dependent on the geometry of the enolate, wherein anti and syn BH products are predicted for Z and E enolates, respectively. An interesting secondary orbital interaction between the oxygen atoms of the enolate and aldehyde moieties in the transition states for the C-C bond formation is identified as one of the contributing factors toward the predicted diastereoselectivity in the formation of the alpha-chloromethyl aldol product (P2). It has earlier been reported that under different experimental conditions, any of the three products such as (i) a normal BH product (P1), (ii) 2-(chloromethyl)vinyl ketones (P3), and (iii) alpha-chloro methyl aldol could be generated (Scheme 1 ). The present study offers valuable insights toward rationalizing the observed product distribution as well as diastereoselectivity in TiCl(4)-promoted BH reaction under base-free conditions. The computed energetics indicate that when MVK is employed as the Michael acceptor, the formation of 2-(choromethyl)vinyl ketone is the preferred product rather than the corresponding normal BH product, consistent with the known

  17. Applications of the Vitamin D sterol-Vitamin D receptor (VDR) conformational ensemble model.

    PubMed

    Mizwicki, Mathew T; Bishop, June E; Norman, Anthony W

    2005-01-01

    Over the past 20 years much has been learned about the cellular actions of the steroid hormone 1alpha,25(OH)2-Vitamin D3 (1,25D). Perhaps most importantly structure-function studies led to the discovery that different chemical and physical features of 1,25D are preferred to initiate either exonuclear, non-genomic or endonuclear, genomic cellular signaling. It is well documented that both a 1alpha-OH and 25-OH, and a 6-s-trans, bowl-shaped, sterol conformation are absolutely required for efficient gene transcription, while 6-s-cis locked analogs and 1-deoxy, 25(OH)D3 metabolites activate a variety of non-genomic, rapid responses. These results and the observation that S237 (helix-3; H3) and R274 (H5) are the most static residues in the human 1,25D-Vitamin D receptor (VDR) X-ray construct (see B-values in pdb: 1DB1) and form H-bonds with the 1alpha-OH of 1,25D in the X-ray, genomic pocket (G-pocket), provided the basis for the molecular modeling experiments that led to the discovery of a putative VDR alternative ligand binding pocket (A-pocket). The conformational ensemble model generated from the in silico results provides an explanation for how the VDR can function as a receptor propagating both genomic and non-genomic signaling events. In this report the theoretical gating properties controlling ligand access to the A- and G-pockets will be compared and the model will be used to provide a molecular explanation for the confusing structure-function results pertaining to 1,25D, its side-chain metabolite, 23S,25R-1alpha,25(OH)2-D3-26,23-lactone (BS), and its synthetic two side-chain analog, 21-(3'-hydroxy-3'-methylbutyl)-1alpha,25(OH)2-D3 (KH or Gemini). In addition, evidence that the model is consistent with the pH requirement for Vitamin D sterol-VDR crystallization will be presented.

  18. Solid-state sup 13 C NMR of the retinal chromophore in photointermediates of bacteriorhodopsin: Characterization of two forms of M

    SciTech Connect

    Smith, S.O.; Courtin, J.; van den Berg, E.; Winkel, C.; Lugtenburg, J.; Herzfeld, J.; Griffin, R.G. )

    1989-01-10

    Solid-state {sup 13}C NMR spectra of the M photocycle intermediate of bacteriorhodopsin (bR) have been obtained from purple membrane regenerated with retinal specifically {sup 13}C labeled at positions 5, 12, 13, 14, and 15. The M intermediate was trapped at {minus}40{degree}C and pH = 9.5-10.0 in either 100 mM NaCl (M (NaCl)) or 500 mM guanidine hydrochloride (M (Gdn-HCl)). The {sup 13}C-12 chemical shift at 125.8 ppm in M (NaCl) and 128.1 ppm in M (Gdn-HCl) indicates that the C{sub 13}{double bond}C{sub 14} double bond has a cis configuration, while the {sup 13}C-13 chemical shift at 146.7 ppm in M (NaCl) and 14.57 ppm in M (Gdn-HCl) demonstrates that the Schiff base in unprotonated. The principal values of the chemical shift tensor of the {sup 13}C-5 resonance in both M (NaCl) and M (Gdn-HCl) are consistent with a 6-s-trans structure and a negative protein charge localized near C-5 as was observed in dark adapted bR. The {approximately}5 ppm upfield shift of the {sup 13}C-5 M resonance relative to {sup 13}C-5 bR{sub 568} and bR{sub 548} is attributed to an unprotonated Schiff base in the M chromophore. Of particular interest in this study were the results obtained from {sup 13}C-14 M. In M (NaCl), a dramatic upfield shift was observed for the {sup 13}C-14 resonance relative to unprotonanted Schiff base model compounds. In contrast, in M (Gdn-HCl) the {sup 13}C-14 resonance was observed at 125.7 ppm. The different {sup 13}C-14 chemical shifts in these two M preparations may be explained by different C{double prime}N configurations of the retinal-lysine Schiff base linkage, namely, syn in NaCl and anti in guanidine hydrochloride.

  19. [Study of epidemic area on Tsutsugamushi disease in Taizhou from 2013 to 2014].

    PubMed

    He, Y L; Yang, H Y; Yu, C X; Zhang, X; Yi, Q H; Ma, Z L; Cha, J; Xu, X B; Zhang, Q; Dai, W J; Qian, W J; Yin, J; Zhu, S J; Xu, Z

    2017-03-06

    Objective: To study the epidemiological characteristics of tsutsugamushi disease, and to confirm the existence of the disease's epidemic foci in Taizhou. Methods: From 2013 to 2014, Dongxing town hospital and Xingqiao town hospital were selected as specimen collection sites in Jingjiang city. Blood samples (5 ml) were collected from 40 patients with acute tsutsugamushi disease. A total of 59 rodents were captured with cage night method in the survey sites at 5, 7, 9, 10, and 11 months in 2013, from which, the spleen, liver, and kidney specimens were selected. Chigger mites were captured by small blackboard method and from the ears of the captured rodents. A total of 226 small blackboards were laid, 27 mites were captured, and the samples were grounded into suspension. Nested-polymerase chain reaction and cell and tissue culture techniques were used to test the specimen from the probable patients, host animals and chigger mites. Results: Among the 40 acute tsutsugamushi disease blood samples, 29 were found to meet the test requirements, 17 were positive for orientia tsutsugamushi nucleic acid with 59% of the positive rate, and 1 stran orientia tsutsugamushi was isolated. 59 rats were captured and the density of mice was 5.5%. Among them, there were 26 Mus musculus (2.4%), 18 Rattus flavipectus (1.7%) and 15 Smelly shrew (density 1.4%). 1 Smelly shrew was tested positive for orientia tsutsugamushi nucleic acid, and the negative results were found in the other rodent specimens. 27 Chigge mites were collected by small blackboard method and the density of mites was 0.12 for each blackboard, among which 3 larvae and 24 nymphs were found. 33 Chigger mites were collected from the ears of 3 Smelly shrew, and the density of the mite was 11 per mouse. All the captured Chigger mites were identified as Leptotrombidium scutellare and 1 group of specimens of Chigger mites from the external environment were positive for orientia tsutsugamushi nucleic acid. Conclusion: There was a

  20. Stable large-scale CO2 storage in defiance of an energy system based on renewable energy - Modelling the impact of varying CO2 injection rates on reservoir behavior

    NASA Astrophysics Data System (ADS)

    Bannach, Andreas; Hauer, Rene; Martin, Streibel; Stienstra, Gerard; Kühn, Michael

    2015-04-01

    The IPCC Report 2014 strengthens the need for CO2 storage as part of CCS or BECCS to reach ambitious climate goals despite growing energy demand in the future. The further expansion of renewable energy sources is a second major pillar. As it is today in Germany the weather becomes the controlling factor for electricity production by fossil fuelled power plants which lead to significant fluctuations of CO2-emissions which can be traced in injection rates if the CO2 were captured and stored. To analyse the impact of such changing injection rates on a CO2 storage reservoir. two reservoir simulation models are applied: a. An (smaller) reservoir model approved by gas storage activities for decades, to investigate the dynamic effects in the early stage of storage filling (initial aquifer displacement). b. An anticline structure big enough to accommodate a total amount of ≥ 100 Mega tons CO2 to investigate the dynamic effects for the entire operational life time of the storage under particular consideration of very high filling levels (highest aquifer compression). Therefore a reservoir model was generated. The defined yearly injection rate schedule is based on a study performed on behalf of IZ Klima (DNV GL, 2014). According to this study the exclusive consideration of a pool of coal-fired power plants causes the most intensive dynamically changing CO2 emissions and hence accounts for variations of a system which includes industry driven CO2 production. Besides short-term changes (daily & weekly cycles) seasonal influences are also taken into account. Simulation runs cover a variation of injection points (well locations at the top vs. locations at the flank of the structure) and some other largely unknown reservoir parameters as aquifer size and aquifer mobility. Simulation of a 20 year storage operation is followed by a post-operational shut-in phase which covers approximately 500 years to assess possible effects of changing injection rates on the long-term reservoir

  1. Developmental profile of neurogenesis in prenatal human hippocampus: an immunohistochemical study.

    PubMed

    Yang, Pengbo; Zhang, Junfeng; Shi, Hangyu; Zhang, Jianshui; Xu, Xi; Xiao, Xinli; Liu, Yong

    2014-11-01

    Hippocampus has attracted the attention of the neuroscientists for its involvement in a wide spectrum of higher-order brain functions and pathological conditions, especially its persistent neurogenesis in subgranular zone (SGZ). The development of hippocampus was intensively investigated on animals such as rodents. However, in prenatal human hippocampus, little information on the distribution of neural stem/progenitor cells, newly generated neurons and mature neurons is available and the timetable of a series of neurogenesis event is even more obscure. So in the present study, we aim at immunohistochemically providing more information on neurogenesis in prenatal human hippocampus from 9 weeks to 32 weeks of gestation. We found that the ki67-positive cells were always detected in hippocampus from 9 weeks to 32 weeks, with a peak at 9 weeks in cornu ammonis (CA) or 14 weeks in dentate gyrus (DG). At 9 weeks the nestin-expressing cells were distributed throughout the hippocampus, with concentrated immunoreactivity in intermediate zone (IZ), marginal zone (MZ), fimbria, and relatively sparse immunoreactivity in the ventricular zone (VZ) and hippocampal plate (HP). With development, the optical density (OD) and the number of nestin-positive cells decreased gradually. At 32 weeks, there were relatively more nestin-positive cells in DG than that in CA. About DCX-positive cells, they displayed a similar distribution as nestin-positive cells (immunoreactivity concentrated in IZ, MZ, fimbria and HP) and a dramatic decrease of OD or cell number density from 9 weeks on. NeuN-positive cells, with small nuclei, were firstly found in MZ and subplate of hippocampus at 9 weeks. After 14 weeks, many NeuN-positive cells extended from subplate into HP and the density of NeuN-positive cells peaked at 22 weeks. That the immunoreactivity for NeuN was the strongest and the nuclei were the biggest at 32 weeks suggests that the neurons reach maturity gradually. Therefore this study provides

  2. Explosively erupted magmas with relatively quiescent differentiation stories. Examples from Sierra Nevada, México

    NASA Astrophysics Data System (ADS)

    Sosa-Ceballos, G.; Macias, J.; Garduño-Monroy, V. H.

    2013-12-01

    Sierra Nevada is a N-S aligned volcanic range in central Mexico, located approximately 65 km SE of Mexico City. It is formed by Telapón, Tláloc, Iztaccíhuatl, and Popocatépetl volcanoes. Popocatepetl have had at least five Plinian eruptions in the last 23 ky and at least two sector collapses that partially destroyed the volcanic edifice. Iztaccíhuatl explosive history is less constrained than Popocatepetl's but a debris avalanche deposit suggest that at least one sector collapse affected the volcano. The most recent debris avalanche deposits from Popocatépetl (23 ky) and Iztaccíhuatl (430 ky) are crowned by fall deposits produced by an explosive eruption. Compared to the other Plinian magmas from Popocatepetl, the WP magma (Popocatepetl) and the IZ-4 magma (Iztaccíhuatl) are slightly more evolved (65-66 wt. % SiO2), do not contain any xenocryst suggesting mixing with more mafic magmas (olivine, Mg-rich pyroxene, or Cr-rich magnetite), their frequency of mixing events is lower, disequilibrium textures like sieving are absent, and at least for the WP magma, evidence of upper crust assimilation is negligible. In addition, equilibrium of Fe-Ti oxides, CO2 and water concentrations analyzed in melt inclusions, and hydrothermal experiments yield that the pre-eruptive conditions of both magmas are approximately ~910 °C and <200 MPa. The pressure of storage is greater compared to the other Plinain magmas from Popocatepetl, ~130 MPa. It is well known that magma mixing could trigger explosive eruptions. However, in contrast to all other Plinian eruptions from Popocatepetl, the WP and IZ-4 magmas seem to being predominately crystallizing with no major effects from mixing and/or assimilation, and that they were tapped just because of the effect produced on the pressure gradient by the sector collapse. This is important for present day monitoring of Popocatépetl activity, because it seems that the deeper reservoir is less prone for mixing and that the accumulation of

  3. VizieR Online Data Catalog: Dynamical parameters of open clusters (Danilov+, 2012)

    NASA Astrophysics Data System (ADS)

    Danilov, V. M.; Putkov, S. I.

    2012-11-01

    α0 - is the mean value of a virial factor, δ{alp the amplitude of virial factor oscillations, ν={rho}c/{rho}0-is the density contrast ({rho}c - is the mean density of a cluster core, {rho}0 - is the cluster centre density), NK/N - is the ratio of the stars number in a cluster received by King's distribution and by stellar counts, P1-is the period of cluster core oscillations, P2 - is the period of cluster oscillations, δR1/R10-is the relative amplitude of core radius oscillations, λ=σ/σiz, σiz2 - is the velocity dispersion of an isolated virialized cluster, σ2, σ12, σ22 - are the velocity dispersions of nonisolated nonsteady clusters with spherical halo; with ellipsoidal halo elongated to the centre of Galaxy; with ellipsoidal halo elongated to the direction of cluster motion correspondingly. Errors of values α0, δα, δR1/R10, P1 have been estimated by the assumption of the normal distribution of the values M (the mass of a cluster), R2 (the radius of a cluster), {xi} (the ratio of core radius to halo radius), μ (the ratio of core mass to halo mass). Assuming a deviation of one of the four values equal to zero we receive four sections of 1σ-errors ellipsoid. These sections are the spheres of radius 20.5. Taking points on each sphere with the step 0.25*π on angular coordinates we receive 96 points on a surface of the 1σ-errors ellipsoid. The values α0, δα, δR1/R10, P1 were calculated in the 96 points. The centre of the ellipsoidal was used for calculation of the mean values. The errors of the values were computed as root-mean-squire deviations of 96 values from the same mean values. The errors of the others values of the catalog were computed by the errors calculation rule of indirect measuring. (3 data files).

  4. Rapid extraction and purification of environmental DNA for molecular cloning applications and molecular diversity studies.

    PubMed

    Santosa, D A

    2001-01-01

    A rapid method for the extraction and purification of DNA from environmental samples for molecular cloning applications was developed. The indigenous cells from plant debris, organic materials, sediments, and soils were lysed directly by using DAS-IZ solution and the nucleic acids were precipitated with isopropanol. A simple purification step using DAS-IIZ solution without binding matrix produced highly pure, colorless and undegraded DNA with molecular weight of more than 20 kb. The superiority of this method was tested for wide applications in molecular cloning, i.e., construction of genomic library by using Lambda DASHII Vector and GigapackIII XL, plasmid library, cloning of gene encoding protease, and molecular microbial diversity analysis. An additional advantage of this method is that only 0.1 g of sample is required, if analysis of many samples in short time should be done. To extract large amounts of environmental DNA for molecular cloning lasts only 30 min and to purify it less than 1 h.

  5. All Prime Contract Awards by State or Country, Place and Contractor. Part 3. (Lemon Grove, California-San Bruno, California)

    DTIC Science & Technology

    1989-01-01

    114I 4 -4 I* .4- 4-4 N 4 ( 4N on 4 -4 -4 in 4 1I1 HW4N4HIH1 " ’-4-4* HU-4 HO- U- U- HN ION VN 4 IUD 󈧈 gg2H00-INO 110-2 020 02 02 02 0 (D IZ r2 (D 02...Nl < w0) w LLI :1ICO I Mri 11--4 0.-40)= <-I w D 00 n W N 0 ~ 1 _III CN 11>0C -(001--~ ( W 1- 00 Lot1 (nc l) 0C-- 0 a)-411W ICON cc~ 44N2 04 ’I z w4...WI H I 0000 If 0-4 000000- 000000000 -400 ’-4000000 -400)0 CI 0 % -40 .0 .4000 .0 00 110 󈧅 0 M I M 11 - >4. 1 4 2 40 10 cmNe o- . 00: II MrI 0000

  6. Erato polymnioides - A novel Hg hyperaccumulator plant in ecuadorian rainforest acid soils with potential of microbe-associated phytoremediation.

    PubMed

    Chamba, Irene; Rosado, Daniel; Kalinhoff, Carolina; Thangaswamy, Selvaraj; Sánchez-Rodríguez, Aminael; Gazquez, Manuel Jesús

    2017-12-01

    Mercury (Hg) accumulation capacity was assessed in three plant species (Axonopus compressus, Erato polymnioides, and Miconia zamorensis) that grow on soils polluted by artisanal small-scale gold mines in the Ecuadorian rainforest. Individuals of three species were collected at two sampling zones: i) an intensive zone (IZ, 4.8 mg Hg kg(-1) of soil) where gold extraction continues to occur, and ii) a natural zone (NZ, 0.19 mg Hg kg(-1) of soil). In addition, the percentage of arbuscular mycorrhizal fungi (AMF) colonization was determined in plant roots and seven fungal morphotypes isolated from rhizospheric soil. Results suggest a facilitation role of native and pollution adapted AMF on Hg phytoaccumulation. E.g., E. polymnioides increased Hg accumulation when growing with greater AMF colonization. We concluded that E. polymnioides is a good candidate for the design of microbe-assisted strategies for Hg remediation at gold mining areas. The consortia between E. polymnioides and the AMF isolated in this study could be instrumental to get a deeper understanding of the AMF role in Hg phytoaccumulation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. The biological and toxicological activity of gases and vapors.

    PubMed

    Abraham, Michael H; Sánchez-Moreno, Ricardo; Gil-Lostes, Javier; Acree, William E; Cometto-Muñiz, J Enrique; Cain, William S

    2010-03-01

    A large amount of data on the biological and toxicological activity of gases and vapors has been collected from the literature. Processes include sensory irritation thresholds, the Alarie mouse test, inhalation anesthesia, etc. It is shown that a single equation using only five descriptors (properties of the gases and vapors) plus a set of indicator variables for the given processes can correlate 643 biological and non-lethal toxicological activities of 'non-reactive' compounds with a standard deviation of 0.36 log unit. The equation is scaled to sensory irritation thresholds obtained by the procedure of Cometto-Muñiz, and Cain provides a general equation for the prediction of sensory irritation thresholds in man. It is suggested that differences in biological/toxicological activity arise primarily from transport from the gas phase to a receptor phase or area, except for odor detection thresholds where interaction with a receptor(s) is important. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

  8. Manuscript "Collection of Solved Problems of General Astronomy" by Vojislav Miskovic

    NASA Astrophysics Data System (ADS)

    Pejovic, N.

    2009-09-01

    In this paper we present the first university problems book concerning astronomy written in Serbian. The topic is "Zbirka rešenih zadataka iz opšte astronomije" (A Collection of Solved Problems of General Astronomy) by Prof. Vojislav Mi\\vsković. The first part of this collection was published in 1956 in Belgrade. The second one is still in the form of a manuscript. Though completely prepared for publishing, it has never been published. From the methodical point of view the collection was interestingly and nicely arranged. All astronomical notions and formulae are treated in details and well explained so that no complementary textbook is needed. A special attention is devoted to the numerical solution of the problems, which is not only missing in Serbian schools, but also, as said by Mi\\vsković in the Preface, is not properly valued. This paper treats both parts of this Collection which have been digitized and are available in the Virtual Library of the National Digitization Centre (Virtual Library, http://elib.matf.bg.ac.yu:8080/virlib/). By means of the manuscript digitization the second part of the Collection has become available to public use.

  9. Baker Lake, Northwest Territories, Canada. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

    DTIC Science & Technology

    1972-01-13

    JAt fl0 4 AKFII LAKh’ N0T 001T I5m66 APR STATION STATION RAK9 lIARS MONTH ALL WEAT.HR 0600*0800 HOURS (L S.t,) CONDITION SPEED MEAN (KNTS) 1 .3 4.6 7...F -7" ! 919 V11 VT3 9 92,Oj NvJ3t ,oo0 69,9 i1t6,6 7t7 O f 83. 442 5of 8013 8O,4 91q4 9il 9207 94,6 94s7 97,0 99,0 8 00 D 99 9166 7’$#U U O9 03,9...1 5 7 17’i V11 / 1,7 6 3 3 3 6 . 14/13 .2 ___ 2 2IZ/ 11 3 D/ 9 _- UTAL 149.8,8.73. ,0 ,7 -540 $40 I ___ _ _ -I- __0 540 Element (X) - xz Z X VA No

  10. DECam Survey for Substellar and Low-mass Stellar Members of Sco-Cen

    NASA Astrophysics Data System (ADS)

    Mamajek, Eric E.; Moolekamp, Fred; James, David; Luhman, Kevin; Pecaut, Mark; Metchev, Stanimir A.; Denbo, Sara; Bell, Cameron P. M.

    2017-01-01

    We present the results of a DECam imaging survey for low-mass stellar and substellar objects in the nearby Sco-Cen OB association. The DECam survey was taken in izY bands in 2013 and 2015 and covered $\\sim$87 deg$^2$ in the two nearest and oldest subgroups, Upper Cen-Lup ($\\sim$142 pc) and Lower Cen-Cru ($\\sim$118 pc; both with mean ages $\\sim$16 Myr). Using color-magnitude and proper motion selection, we identify 391 candidate Sco-Cen members with masses ranging from near the D-burning limit of $\\sim$13 M$_{Jup}$, through the H-burning limit, up to $\\sim$0.4 M$_\\odot$. Our initial spectroscopic follow-up with the ARCoIRIS and COSMOS spectrographs for 19 objects have yielded young M dwarfs showing signatures of low surface-gravity. Our survey yields the first constraints on the substellar and low-mass initial mass function and disk fraction in the two oldest Sco-Cen subgroups, and will yield a large sample of young, low-surface gravity M and L-type objects of constrained age, distance, and chemical composition. We acknowledge support from NSF award AST-1313029 and the REU Site in Physics and Astrophysics at the University of Rochester supported by NSF award PHY-1156339.

  11. Fourier series and {delta}-subharmonic functions of finite {gamma}-type in a half-plane

    SciTech Connect

    Malyutin, K G

    2001-06-30

    Let {gamma}(r) be a growth function and let v(z) be a proper {delta}-subharmonic function in the sense of Grishin in a complex half-plane, that is v=v{sub 1}-v{sub 2}, where v{sub 1} and v{sub 2} are proper subharmonic functions (limsup{sub z{yields}}{sub t}v{sub i}(z){<=}0, for each real t, i=1,2), let {lambda}={lambda}{sub +}-{lambda}{sub -} be the full measure corresponding to v and let T(r,v) be its Nevanlinna characteristic. The class J{delta}({gamma}) of functions of finite {gamma}-type is defined as follows: v element of J{delta}({gamma}) if T(r,v){<=}A{gamma}(Br)/r for some positive constants A and B. The Fourier coefficients of v are defined in the standard way. The central result of the paper is the equivalence of the following properties: (1) v element of J{delta}({gamma}); (2) N(r){<=}A{sub 1}{gamma}(B{sub 1}r)/r, where N(r)=N(r,{lambda}{sub +}) or N(r)=N(r,{lambda}{sub -}), and |c{sub k}(r,v)|{<=}A{sub 2}{gamma}(B{sub 2}r). It is proved in addition that J{delta}({gamma})=JS({gamma})-JS({gamma}), where JS({gamma}) is the class of proper subharmonic functions of finite {gamma}-type.

  12. Photometric Classification of Stars, Galaxies and Quasars in the Sloan Digital Sky Survey DR6 Using Support Vector Machines

    NASA Astrophysics Data System (ADS)

    Elting, C.; Bailer-Jones, C. A. L.; Smith, K. W.

    2008-12-01

    This paper describes the automated classification of objects from the DR6 release of the Sloan Digital Sky Survey (SDSS) using support vector machines (SVM). First the SVM classifier was trained on a dataset comprising the u-g, g-r, r-i and i-z colours of 47,401 stars, 415,634 galaxies and 71,031 quasars with spectral classifications. An analysis of the performance of the classifier showed a total classification error of 3.80% and demonstrates that the SVM is efficiently able to learn the non-linear, four dimensional class boundaries. Afterwards class membership probabilities for stars, galaxies and quasars were predicted for 12,362,179 objects in DR6 without spectra which were situated within the inner 90% of the training colour space and had magnitude errors below 10%. The SVM predicted 11,012,775 stars, 1,088,862 galaxies and 260,542 quasars. The relatively high number of galaxies can be explained by our constraints on colours and magnitude errors. The results were validated by cross-matching against the FIRST and USNO-B surveys. The cross-match with FIRST resulted in 8,666 radio sources of which the SVM classifier predicted 94.8% to be galaxies or quasars as expected.

  13. Development of a Gun Wear Data Bank.

    DTIC Science & Technology

    1979-11-01

    0 *. i Pf U, .0 UI i4f)’ IL Ib .1 9. 0. CL i’ CL a .9 VY 4 1 ti 0 as if ofi0 if 0 11 If 0 Nif 0 ; 1 t 1 0 0 Cn in .0 0to a000/ 00 0 00u nin0 s0 It0W... C6 - -e 4r& 41 . 9 .4 4 U’ III t a’ - a mw ’a w a " axIt c IL a IL IL N 4 .4 .4 .4 .4 . . . 4u 4 ow w w w4& of 040 NN0 mi 11 1 .P . ’j 3o** 3. p 2...VPv o0w w 0 ,4 P 0 1, OV 1.0 44. 0. OS14 I O IZ fu. , Im t’ V0 . , .4 .4J so w.. -0 W.. . .W.. W- . . . . ..WatjW-ll , nIf "In~ ww ~ I 4 if @4 v)V)i w

  14. Ovine catarrhal fever (Bluetongue): analysis of Culicoides species in seropositive farms.

    PubMed

    Guercio, A; Di Marco, P; Manno, C; Di Bella, C; Purpari, G; Torina, A

    2010-04-01

    Bluetongue (BT) is an orbiviral disease of wild and domestic ruminants, mainly sheep. In Sicily, the first Bluetongue outbreak occurred in October 2000; there have been 76 recorded outbreaks so far. The National Surveillance Plan, based on European Union Commission Decision 138/2001/CE, establishes serological and entomological surveys. This plan consists of controls of seronegative cattle, called 'sentry' as indicators for the presence and circulation of virus in defined areas. To check the seroconversions, the regional territory has been subdivided in 400 km(2) areas including 58 seronegative cattle, periodically checked by serological tests. All positive sera have been tested to detect the specific serotype by the National Reference Centre for Exotic Diseases (CESME) at the Istituto Zooprofilattico Sperimentale Abruzzo e Molise in Teramo (IZS Teramo). Moreover, entomological surveillance has been implemented in seropositive herds, to investigate the presence of insect vectors belonging to Culicoides genus. The goal of the present communication is to report on the different species of Culicoides found in the farms with Bluetongue virus and to investigate on the probable role of new competent vectors. This paper concerns data analysis of 581 light-trap catches collected in 321 farms from 2003 to 2008. We observed that 82% of checked farms were positive for Culicoides spp., and only 10% of the farms were positive for Culicoides imicola.

  15. KMOS Clusters and VIRIAL GTO Surveys

    NASA Astrophysics Data System (ADS)

    Wilman, D.; Bender, R.; Davies, R. L.; Mendel, J. T.; Chan, J.; Beifiori, A.; Houghton, R.; Saglia, R.; Schreiber, N. Förster; Wuyts, S.; van Dokkum, P.; Cappellari, M.; Stott, J.; Smith, R.; Fossati, M.; Kulkarni, S.; Seitz, S.; Fabricius, M.; Sharples, R.; Brammer, G.; Nelson, E.; Momcheva, I.; Wegner, M.; Lewis, I.

    2015-02-01

    We present the KMOS (K-band Multi-Object Spectrograph) Cluster and VIRIAL (VLT IR IFU Absorption Line) Guaranteed Time Observation (GTO) programs. KMOS provides 24 arms each feeding an integral field unit (14×14 spaxels of 0.2'' pixels) for IZ, YJ, H and K band near infrared (NIR) medium resolution spectroscopy (R ~ 3500). Targets are selected from a 7.2' diameter patrol field. Ultra-deep spectroscopy of ~ 80 early-type cluster galaxies (~ 20hr on source) and ~ 200 (~ 10hr on source) early-type field galaxies at 1 < z < 2 will dramatically improve the situation at z > 1 for which measurements of stellar velocity dispersions and absorption indices are limited to a few, often relatively young passively evolving galaxies (e.g. Bezanson 2013). In ESO Periods P92 and P93, 15 nights worth of data has been collected for KMOS-Clusters and 6 nights for VIRIAL: this will be supplemented with more data in upcoming semesters. All galaxies have multiband HST imaging including existing or upcoming WFC3 IR imaging, providing stellar mass maps and sizes. Combined with our dispersion measurements, this will allow us to examine the fundamental plane and the dynamical mass of a large sample of z > 1 galaxies for the first time, for both cluster and field galaxies.

  16. Intergalactic Lyman continuum photon budget in the past 5 billion years

    NASA Astrophysics Data System (ADS)

    Gaikwad, Prakash; Khaire, Vikram; Choudhury, Tirthankar Roy; Srianand, Raghunathan

    2017-04-01

    We constrain the H I photoionization rate (Γ _{H I}) at z ≲ 0.45 by comparing the flux probability distribution function and power spectrum of the Lyα forest data along 82 Quasi-Stellar Object (QSO) sightlines obtained using Cosmic Origins Spectrograph with models generated from smoothed particle hydrodynamic simulations. We have developed a module named 'Code for Ionization and Temperature Evolution (CITE)' for calculating the intergalactic medium (IGM) temperature evolution from high to low redshifts by post-processing the GADGET-2 simulation outputs. Our method, that produces results consistent with other simulations, is computationally less expensive thus allowing us to explore a large parameter space. It also allows rigorous estimation of the error covariance matrix for various statistical quantities of interest. We find that the best-fitting Γ _{H I}(z) increases with z and follows (4 ± 0.1) × 10-14 (1 + z)4.99 ± 0.12 s-1. At any given z, the typical uncertainties Δ Γ _{H I} / Γ _{H I} are ∼25 per cent that contains not only the statistical errors but also those arising from possible degeneracy with the thermal history of the IGM and cosmological parameters and uncertainties in fitting the QSO continuum. These values of Γ _{H I} favour the scenario where only QSOs contribute to the ionizing background at z < 2. Our derived 3σ upper limit on average escape fraction is 0.008, consistent with measurements of low-z galaxies.

  17. Occurring mechanism and restraining method research of numerical noise signal in penetration simulation

    NASA Astrophysics Data System (ADS)

    Wang, Chen; Wang, Yabin

    2016-09-01

    In hard target penetration simulation, the existing researches of the convergence of results are mainly concentrating in the corresponding relationship between penetration depth and mesh scales. However, the influence of the mesh difference on the penetration resistance and acceleration signals are seldom refer to. This paper presents the occurring mechanism and restraining method of numerical noise signal in penetration simulation. First, the concept of the noise signal izs proposed. By taking a 3D penetration simulation as example, the influence of the noise signal on the penetration resistance in different mesh scales and impact velocity is studied. To ensure the convergence of the computational results, the grid scale of the target is encrypted to 1:1:8. In addition, modern spectrum analysis method is introduced to further analyze the penetration resistance signal. The research results presented is useful to improve the computational accuracy of high speed projectile penetration simulation, and provide important reference for carrying out structural design and optimization of fuze system.

  18. Functional calculus using wavelet transforms

    NASA Astrophysics Data System (ADS)

    Holschneider, Matthias

    1994-07-01

    It is shown how the wavelet transform may be used to compute for a function s the symbol s(A) for any (not necessarily) self-adjoint operator A whose spectrum is contained in the upper half plane. For self-adjoint operators it is shown that this functional calculus coincides with the usual one. In particular it is shown how the exponential eitA can be written in terms of the resolvent Rz=(A-z)-1 of A as follows: eitA=(1/c) ∫0∞da an-2∫-∞+∞ dbĝ¯ (at)eitbRb-ian(A), with c=-2iπ×∫0∞(dω/ω) (-iω)n-1ĝ¯(ω)e-ω, and n∈N, and the integral is understood as the Cesaro limit. This shows explicitly how the behavior for large t is determined by the behavior of Rz at Iz ≂1/t.

  19. Word Criticality Analysis. MOS: 16B. Skill Levels 1 & 2

    DTIC Science & Technology

    1981-09-01

    COMMAND FORT MONROE, VIRGINIA 23651 - A-9 1916 A., ’F 41 IIL SEQUJENTIAL CATA AGE 4 A’~~s~ ,~.. ~ AG 1C 2 TYPE MEORO By-. S5 ANC ~,(f A ZA’I’L Y elt *4...il #1 1l, 13. 1)1 1.;, IC , !. 1 !*2,t Ict ’. 9201 96,V1 - 95, 9C92 es.* 64. ,. 6z[*4 ’-.’ !9,1 !6,1. T.1 61o 669. 659. -.,1 %, 55, 56p: 45.1 4, 47.2...4 SliEL 57.1 let! 4 S t - Y-S fE P lot 4 SHV-r 2)01 4 ST i.Z. ).h. 4 ’ I.ACI 7t- 4 S)C’ 1s 1 98.gl 7.1 4 sIrf.. E !#I 141.1 UN3.1 4 sc i C,± ict

  20. Atomic scale contact formation: A combined Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM) study

    NASA Astrophysics Data System (ADS)

    Hagedorn, Till; El Ouali, Mehdi; Miyahara, Yoichi; Grütter, Peter

    2008-03-01

    We are investigating contact formation at the atomic scale, in particular the interplay of forces and conductivity [1]. As it has been shown (e.g. in the case of C60 in between a STM tip and an Au(111) sample [2]), the conductivity in molecular junctions depends strongly on the contact geometry. In order to fully characterize the junction, we use a homebuilt ultra high vacuum (UHV) (p < 10-10 mbar) microscope which runs in simultaneous scanning tunneling microscope (STM) and atomic force microscope (AFM) modes. Additionally we image the STM tip structure with field ion microscopy (FIM) prior to using it in our experiments [3]. In order to realize a controlled contact we use the STM tip as one electrode and the sample as counter electrode. We are investigating bare Au(111) samples and W STM tips as an example of a nano metal-metal contact and one C60 molecule sandwiched between the W-tip and the Au(111) sample as a model for a controlled metal-molecule-metal contact. We will present new measurements of I(z), F(z) and dI/dV (z) curves of the above mentioned systems, where z is the tip-sample separation as well as images of the sample and tip structure. [1] Sun et. al. PRB 71 193407, 2005 [2] De Menech et. al. PRB 73, 155407, 2006 [3] Lucier et. al. PRB 72, 235420, 2005

  1. Evaluating the impact of climate change on groundwater resources in a small Mediterranean watershed.

    PubMed

    Ertürk, Ali; Ekdal, Alpaslan; Gürel, Melike; Karakaya, Nusret; Guzel, Cigdem; Gönenç, Ethem

    2014-11-15

    Western Mediterranean Region of Turkey is subject to considerable impacts of climate change that may adversely affect the water resources. Decrease in annual precipitation and winter precipitation as well as increase in temperatures are observed since 1960s. In this study, the impact of climate change on groundwater resources in part of Köyceğiz-Dalyan Watershed was evaluated. Evaluation was done by quantifying the impacts of climate change on the water budget components. Hydrological modeling was conducted with SWAT model which was calibrated and validated successfully. Climate change and land use scenarios were used to calculate the present and future climate change impacts on water budgets. According to the simulation results, almost all water budget components have decreased. SWAT was able to allocate less irrigation water because of the decrease of overall water due to the climate change. This resulted in an increase of water stressed days and temperature stressed days whereas crop yields have decreased according to the simulation results. The results indicated that lack of water is expected to be a problem in the future. In this manner, investigations on switching to more efficient irrigation methods and to crops with less water consumption are recommended as adaptation measures to climate change impacts.

  2. Rosmarinus officinalis essential oil: antiproliferative, antioxidant and antibacterial activities.

    PubMed

    Hussain, Abdullah Ijaz; Anwar, Farooq; Chatha, Shahzad Ali Shahid; Jabbar, Abdul; Mahboob, Shahid; Nigam, Poonam Singh

    2010-10-01

    The aim of this work was to investigate and compare the antiproliferative, antioxidant and antibacterial activities of Rosmarinus officinalis essential oil, native to Pakistan. The essential oil content from the leaves of R. officinalis was 0.93 g 100g(-1). The GC and GC-MS analysis revealed that the major components determined in R. officinalis essential oil were 1,8-cineol (38.5%), camphor (17.1%), α-pinene (12.3%), limonene (6.23%), camphene (6.00%) and linalool (5.70%). The antiproliferative activity was tested against two cancer (MCF-7 and LNCaP) and one fibroblast cell line (NIH-3T3) using the MTT assay, while, the antioxidant activity was evaluated by the reduction of 2, 2-diphenyl-1-picryl hydrazyl (DPPH) and measuring percent inhibition of peroxidation in linoleic acid system. The disc diffusion and modified resazurin microtitre-plate assays were used to evaluate the inhibition zones (IZ) and minimum inhibitory concentration (MIC) of R. officinalis essential oil, respectively. It is concluded from the results that Rosmarinus officinalis essential oil exhibited antiproliferative, antioxidant and antibacterial activities.

  3. Relationship between Food Intake and Sleep Pattern in Healthy Individuals

    PubMed Central

    Crispim, Cibele Aparecida; Zimberg, Ioná Zalcman; dos Reis, Bruno Gomes; Diniz, Rafael Marques; Tufik, Sérgio; de Mello, Marco Túlio

    2011-01-01

    Study Objectives: The purpose of this study was to analyze the relationship between food intake and sleep patterns in healthy individuals. Methods: Fifty-two healthy volunteers (27 women and 25 men) were recruited to participate in the study. Volunteers underwent sleep evaluation through nocturnal polysomnography and completed a 3-day food diary to evaluate food intake. Results: No differences in sleep patterns were observed in either gender, except in the percentage of stage 1 sleep, which was greater in men. Different correlations were observed between sleep and dietary variables according to gender. The correlation between dietary and sleep variables in men indicated a negative relationship between nocturnal fat intake and the sleep latency, including REM sleep. The percentage of nocturnal fat intake correlated with sleep efficiency, sleep latency, REM latency, stage 2 sleep, REM sleep, and wake after sleep onset (WASO) in women. The percentage of nocturnal caloric intake correlated with sleep latency and efficiency in women. Conclusions: We conclude that food intake during the nocturnal period is correlated with negative effects on the sleep quality of healthy individuals. Indeed, food intake near the sleeping period (dinner and late night snack) was negatively associated with sleep quality variables. More studies are necessary to elucidate the real effect of food intake on sleep. Citation: Crispim CA; Zimberg IZ; dos Reis BG; Diniz RM; Tufik S; de Mello MT. Relationship between food intake and sleep pattern in healthy individuals. J Clin Sleep Med 2011;7(6):659-664. PMID:22171206

  4. Balsscallichirus Sakai, 2011 (Decapoda: Axiidea: Callianassidae) in the fossil record: systematics and palaeobiogeography

    PubMed Central

    Hyžný, Matúš

    2016-01-01

    The fossil record of the ghost shrimp genus Balsscallichirus Sakai, 2011 (Crustacea: Decapoda: Callianassidae) is revised. Barnardcallichirus Sakai, 2011 and Tirmizicallichirus Sakai, 2011 are considered subjective synonyms of Balsscallichirus. Based on the examination of extant species it is argued that the morphology of the major cheliped merus, in combination with other hard part morphology characters, is sufficient for assignment of the fossil material into the genus. Main identifying characters are on merus which is keeled along its midline and its lower half is tuberculated; its lower margin possesses broad proximal meral hook continuing into a lobe distally; the entire lower margin is subdivided into numerous irregularly spaced spines. Three species, Callianassa sismondai A. Milne-Edwards, 1860, C. floriana Glaessner, 1928, and Podocallichirus laepaensis Hyžný & Muñiz, 2012, originally described from the Miocene of Italy, Austria and Spain, respectively, are assigned to Balsscallichirus herein. Neocallichirus wellsi Schweitzer, Feldmann & Gingerich, 2004 from the Upper Eocene of Pakistan is tentatively assigned to that genus as well. Spatial and temporal distribution of the genus indicates that at least since the Oligocene, and possibly even sooner (the Late Eocene), the genus has been restricted to the Western Tethys Region. Later, it migrated also into West Atlantic establishing present day communities. PMID:27499568

  5. Morphology and the Color-mass Diagram as Clues to Galaxy Evolution at z&approx1

    NASA Astrophysics Data System (ADS)

    Powell, Meredith C.; Urry, C. Megan; Cardamone, Carolin N.; Simmons, Brooke D.; Schawinski, Kevin; Young, Sydney; Kawakatsu, Mari

    2017-01-01

    We study the significance of mergers in the quenching of star formation in galaxies at z∼ 1 by examining their color–mass distributions for different morphology types. We perform two-dimensional light profile fits to GOODS iz images of ∼5000 galaxies and X-ray selected active galactic nucleus (AGN) hosts in the CANDELS/GOODS-north and south fields in the redshift range 0.7< z< 1.3. Distinguishing between bulge-dominated and disk-dominated morphologies, we find that disks and spheroids have distinct color–mass distributions, in agreement with studies at z∼ 0. The smooth distribution across colors for the disk galaxies corresponds to a slow exhaustion of gas, with no fast quenching event. Meanwhile, blue spheroids most likely come from major mergers of star-forming disk galaxies, and the dearth of spheroids at intermediate green colors is suggestive of rapid quenching. The distribution of moderate luminosity X-ray AGN hosts is even across colors, in contrast, and we find similar numbers and distributions among the two morphology types with no apparent dependence on Eddington ratio. The high fraction of bulge-dominated galaxies that host an AGN in the blue cloud and green valley is consistent with the scenario in which the AGN is triggered after a major merger, and the host galaxy then quickly evolves into the green valley. This suggests AGN feedback may play a role in the quenching of star formation in the minority of galaxies that undergo major mergers.

  6. X-ray fluorescence analysis of yellow pigments in altarpieces by Valencian artists of the XV and XVI centuries

    NASA Astrophysics Data System (ADS)

    Ferrero, J. L.; Roldán, C.; Ardid, M.; Navarro, E.

    1999-02-01

    XRF analysis has allowed a quick and precise detection and identification of the inorganic elements that compose the yellow pigments in altarpieces of the XV and XVI centuries painted by the Valencian artists Miguel Alcañiz, Vicente Macip, Juan de Juanes, Hernando Yáñez de la Almedina and Hernando Llanos. The analyses have been carried out with an XRF portable system that consists of a tube of X-rays and detectors of Si(Li) and cadmium zinc telluride. This system has enabled a non-aggressive and non-destructive analysis of many pieces at the Museo de Bellas Artes of Valencia (Spain). Among the yellow pigments we have identified a pigment composed by lead and tin oxides named lead-tin yellow (Pb 2SnO 4), frequently used in European paintings from the XIV century until the first half of the XVIII century. This fact demonstrates the influence of elements and pictorial techniques from Europe to the region of Valencia.

  7. Prime Contract Awards by Region and State, Fiscal Years 1981, 1982, 1983.

    DTIC Science & Technology

    1983-01-01

    Z w 0 3 - - ( 40.10 W-- o >10 -2 iI DW0 W00 .On 0.00.In U)ZI 000.1 - 1D -1- 00 11.00100a. 10nX0.DO 0 1- 0 ZOIO) .- I- w >a( a -L0.( -1 w:4: w-0.. 1002...4 o 0 42CDC 0 02 - -2 C) < :-). .w 4 nwo4 00 IL -i 0 V0. 1 0 42: -1 0 01 I D WI 0 0-L wI to)W 0- Wt-(4 s E4La K L..U ! 0 - l..1-2 a- 1D 42:41Z W 4 44 J...EE - C z 10 z CLCC 1 CU(n zIz A z r T cc LO IX. 4- j 0 a 0-0 -Z 0) V)JZC 0 )azaz z tq : Ca C aCa W A. J00 * .J W .4 U-zZO O - EZW LWCa: W V) W

  8. Dollar Summary of Prime Contract Awards by State, County, Contractor and Place. Part 4 (Montgomery-Weston)

    DTIC Science & Technology

    1990-01-01

    I.WMi I GO I co ’Co lGa I I .g o "oc taa smMm E 2 IC )-I 0, W04= L-U A C 0 41 -.- C % . , 0 c I - . - z I >- IL I La. aL 00 Ezw 0 W- Ow 41. uj a I-9 t...34 2 2 2 -4z0 424. 0. I 2l I xx << W CK ZIL I.Rw L z ww 0ww0 w0 (0Z I- 30 ~ C C 0 OO 0Ze C fo I I in6 1D t 0L 4 - in 0C)c Dc r I& U)10 I I. L i 4 CK... 1D L-). IL 00L -U-L~ I0 CL-9 I.- "CUC 9ow I- 004 915)9 (0z 9J x 948o--iz0 0 0-O " 43 -a I" I<C zdw " 0 I -I (0. I " 9 I 04 ~~ I * J WM I UW . . 9 L. LL

  9. Air Force Office of Scientific Research Technical Report Summaries: October - December 1990

    DTIC Science & Technology

    1990-12-01

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  10. Dollar Summary of Prime Contract Awards by State, Place, and Contractor, FY 86. Part 1. (Aliceville, Alabama - Washington, DC).

    DTIC Science & Technology

    1986-01-01

    04 L 010 z 0 C󈧭 - co - 0) 0 0 N 140 k.- -L& - z 0 (n C40w 0I > 1D OCL/)014)( -. z Lmn ’ I L.J . I r4I 01 40N >~ m ~ EC uo ci wl Ln 0fl TIu.r V) ~ 4 1...OZWF- W<aoo0OzC 9 9 z >-ZzzzzI-40 4UUI-9o0 44400w .... 09I0000U.w-(/)9-044444 90 9 9-44j r-41 0 Z SOr I 1 ’ ~0 f-- 1D I J lr.- 00 i 14014 zr >- )-l Mf...o4 WO0 -i ID -) x 4) 1D ~ wow mnoD 0"- 01 x LAo-O~ aInn E Iz 1- w w i . 0 2- < L..X 1-01 <. lnOr-Izz on Zw -0 I-I I0 01- 040 _-i I 0-1I - 0 Dx "l4o

  11. Source Header List. Volume 2. L through Z

    DTIC Science & Technology

    1998-07-01

    WO WU W uWU. WI1- 4 z W .( 4 > Z U 4 Z - 1D I- 4 I-U I- <I-0 I-Z I- I- I-x W 4 W Win 4 3 01M 0 HU4 HH HO " ~ H4 H" H H-. HO U IX WC M I - I-. in ZH...w- z M i i WED Ji m. U 4 D wWmEV w 0- 8 -1 W>0 ( z z u A0 :3l m-U 0 ED 1D 2D2 I- O w "--. ’- iD u’ u )En 44( C) mD ED ED ED LI ED Mi - i W 0 0 .I- 0-I...Nl co 10 C0 0) In 0 10 Cl 02) r- V * - 00 10 - 10 q Cl c0 V 10 C0 1- 10 co 1 r- U N 02) 02)0 M2 020 CV)Nl M2 1D 10 02) c 0 M2 Nl 10 N M 00 1- u z U 2

  12. Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex.

    PubMed

    Liu, Xiuxin; Sun, Lin; Torii, Masaaki; Rakic, Pasko

    2012-05-22

    The prospective pyramidal neurons, migrating from the proliferative ventricular zone to the overlaying cortical plate, assume multipolar morphology while passing through the transient subventricular zone. Here, we show that this morphogenetic transformation, from the bipolar to the mutipolar and then back to bipolar again, is associated with expression of connexin 43 (Cx43) and, that knockdown of Cx43 retards, whereas its overexpression enhances, this morphogenetic process. In addition, we have observed that knockdown of Cx43 reduces expression of p27, whereas overexpression of p27 rescues the effect of Cx43 knockdown in the multipolar neurons. Furthermore, functional gap junction/hemichannel domain, and the C-terminal domain of Cx43, independently enhance the expression of p27 and promote the morphological transformation and migration of the multipolar neurons in the SVZ/IZ. Collectively, these results indicate that Cx43 regulates the passage of migrating neurons through their multipolar stage via p27 signaling and that interference with this process, by either genetic and/or environmental factors, may cause cortical malformations.

  13. Prime Contract Awards Over $25,000 by Major System, Contractor and State. Part 1. AAA Navy A-1 Skyraider thru AVJ Navy OV-10 Coin (Now Bronco)

    DTIC Science & Technology

    1991-01-01

    I. I td C4 - C. * - -4 do m-. c to L--. -4 l-I -4 91---J. 0 - of- 3w )- 2 In I 4LU4 4U x X44Za -4I4L 4 4O.3tG0 4 -4 L -44 C0- C 4 XC 4 L- 39o m rw...O Cc~f IflO*0N00 OOfl0 000 I l CL "> 411) 04 o01 %-) >- %- >--44-4 0-I%’)MD%0(’)(0NC)-( I c I td 3 X -C)) 4-4,4 3: - ’-4- C1W 1 - -4 x0 WV) I. IL...00v< 4&Iz >4 0)4 C c 00 W =Q= * Wo On -44*Cl-4 V4 >1 W0-4 .0 L IL 0 0) 0I . .4 Z LE EUE Udo toX IL) 0 - 8EE4 td 06> MCC..006 ( usa M -4 D . 0.- U.4-0

  14. Dollar Summary of Prime Contract Awards by State, County, Contractor and Place. Part 3 (Midland-Monroe)

    DTIC Science & Technology

    1990-01-01

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  15. Physical Properties of Standard Agents, Candidate Agents, and Related Compounds at Several Temperatures

    DTIC Science & Technology

    1983-06-01

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  16. Antimicrobial isothiocyanates from the seeds of Moringa oleifera Lam.

    PubMed

    Padla, Eleanor P; Solis, Ludivina T; Levida, Ruel M; Shen, Chien-Chang; Ragasa, Consolacion Y

    2012-01-01

    4-(alpha-L-Rhamnosyloxy)benzyl isothiocyanate (1) and 4-(4'-O-acetyl-alpha-L-rhamnosyloxy)-benzyl isothiocyanate (2) isolated from Moringa oleifera seeds were screened for their antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, and Pseudomonas aeruginosa, and for their antifungal activities against Candida albicans, Trichophyton rubrum, and Epidermophyton floccosum using the disk diffusion method. Isothiocyanates 1 and 2 were found active at the lowest inhibitory concentration of 1 mg/ml against all Gram-positive bacteria tested (S. aureus, S. epidermidis, B. subtilis) and against the dermatophytic fungi E. floccosum and T. rubrum. Statistically significant differences were found between the mean inhibition zones (IZ) of 1 and 2 and the standard drugs, ofloxacin and clotrimazole. The minimum inhibitory concentration (MIC) values confirmed the good antimicrobial activity of 1 and 2 against S. aureus, good to moderate activity against S. epidermidis, moderate activity against B. subtilis, and weak activity against E. floccosum and T. rubrum. The in vitro bactericidal effect of 1 and 2 against the Gram-positive bacterial strains tested is suggested by MBC:MIC ratios of 2:1.

  17. Particulate matter (PM₁₀) induces metalloprotease activity and invasion in airway epithelial cells.

    PubMed

    Morales-Bárcenas, Rocío; Chirino, Yolanda I; Sánchez-Pérez, Yesennia; Osornio-Vargas, Álvaro Román; Melendez-Zajgla, Jorge; Rosas, Irma; García-Cuellar, Claudia María

    2015-09-17

    Airborne particulate matter with an aerodynamic diameter ≤ 10 μm (PM10) is a risk factor for the development of lung diseases and cancer. The aim of this work was to identify alterations in airway epithelial (A549) cells induced by PM10 that could explain how subtoxic exposure (10 μg/cm(2)) promotes a more aggressive in vitro phenotype. Our results showed that cells exposed to PM10 from an industrial zone (IZ) and an urban commercial zone (CZ) induced an increase in protease activity and invasiveness; however, the cell mechanism is different, as only PM10 from CZ up-regulated the activity of metalloproteases MMP-2 and MMP-9 and disrupted E-cadherin/β-catenin expression after 48 h of exposure. These in vitro findings are relevant in terms of the mechanism action of PM10 in lung epithelial cells, which could be helpful in understanding the pathogenesis of some human illness associated with highly polluted cities. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. Word Frequency Analysis. MOS: 43E. Skill Levels 1 & 2

    DTIC Science & Technology

    1981-05-01

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  19. Distribution of infective gastrointestinal helminth larvae in tropical erect grass under different feeding systems for lambs.

    PubMed

    Tontini, Jalise Fabíola; Poli, Cesar Henrique Espírito Candal; Bremm, Carolina; de Castro, Juliane Machado; Fajardo, Neuza Maria; Sarout, Bruna Nunes Marsiglio; Castilhos, Zélia Maria de Souza

    2015-08-01

    This study examined tropical pasture contamination dynamics under different feeding systems for finishing lambs. The experiment aimed to evaluate the vertical distribution of gastrointestinal helminth infective larvae (L3) in erect grass subjected to grazing and to assess the parasite load and its impact on lamb performance in three production systems. Three treatments based on Aruana grass (Panicum maximum cv. IZ-5) were as follows: T1, grass only; T2, grass with 1.5% of body weight (BW) nutrient concentrate supplementation; and T3, grass with 2.5% BW concentrate supplementation. The randomized block design had three replicates of three treatments, with six lambs per replicate. L3 were recovered from three pasture strata (upper, middle, and bottom), each representing one third of the sward height, and correlated with microclimatic data. Significant differences (P < 0.05) were observed among treatments in the L3 recovery. Despite different grass heights between treatments and microclimates within the sward, the L3 concentration generally did not differ significantly among the three strata within a treatment (P > 0.05). Pasture microclimate did not correlate with larval recovery. At the end of the experiment, the animal fecal egg count was similar among treatments (P > 0.05). The results indicated that different lamb feeding systems in a tropical erect grassland caused differences in grass height but did not affect the distribution of infective larvae among strata. Larvae were found from the base to the top of the grass sward.

  20. All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 4. Sage Hen, California-Yolo, California.

    DTIC Science & Technology

    1987-01-01

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