Sample records for iz vodoema v-11

  1. VizieR Online Data Catalog: BVR photometry of IZ Mon and AR Dra (Yang+, 2016)

    NASA Astrophysics Data System (ADS)

    Yang, Y.-G.; Dai, H.-F.; Zhou, Z.; Li, Q.

    2016-07-01

    CCD Photometry for IZ Mon and AR Dra, was acquired using the 60cm telescope and the 85cm telescope at the Xinglong station (XLs) of National Astronomical Observatories of China (NAOC). Two telescopes are equipped with the standard Johnson-Cousins UBVRcIc. filters. We then obtained the individual observations as heliocentric Julian dates and differential magnitude, which are listed in Table1. The complete light curves for IZ Mon were obtained on 2009 January 20, 22, 24, 25, and 26, and March 1, using the 85cm telescope. The exposure times are fixed to be 20, 15, and 15s for BVR bands, respectively. A total of 961, 960, and 959 effective images in BVR bands are obtained. Another primary eclipse for IZ Mon was monitored on 2011 January 17. AR Dra was observed on 2009 February 20, 25, 26, and 27, with the 65cm telescope. The typical exposure times are 50, 40 and 40s for BVR bands, which depend on the condition of weather. In total, we obtained 733, 728 and 356 images in B, V and R bands, respectively. (6 data files).

  2. Stress Corrosion-Cracking and Corrosion Fatigue Impact of IZ-C17+ Zinc Nickel on 4340 Steel

    DTIC Science & Technology

    2017-05-17

    REPORT NO: NAWCADPAX/TIM-2016/189 STRESS CORROSION-CRACKING AND CORROSION FATIGUE IMPACT OF IZ-C17+ ZINC-NICKEL ON 4340 STEEL by...CORROSION-CRACKING AND CORROSION FATIGUE IMPACT OF IZ-C17+ ZINC-NICKEL ON 4340 STEEL by Craig Matzdorf Charles Lei Matt Stanley...5a. CONTRACT NUMBER STRESS CORROSION-CRACKING AND CORROSION FATIGUE IMPACT OF IZ-C17+ ZINC-NICKEL ON 4340 STEEL 5b. GRANT NUMBER 5c. PROGRAM

  3. Evaluation of Dipsol IZ-C17 LHE Zinc-Nickel Plating (Briefing Charts)

    DTIC Science & Technology

    2007-01-24

    Results • Based on Successful Test Results an LHE Alkaline Zn-Ni Formula was Selected for Further Development – Identified as Dipsol IZ-C17 (13 to...Hydrogen Embrittlement Test Methods • Select Repair Procedures 16. ENVIRONMENTAL ASSURANCE 2006 Status • IZ-C17 Tech Bulletin (Draft) Prepared...Corrosion Testing (Salt Spray and Galvanic) – Fluid Immersion (ASTM F 483) – Lubricity (Fasteners) – Strippability (BCA – Ammonium Nitrate pH 10) – Throwing

  4. 76 FR 20835 - Amendment of VOR Federal Airways V-1, V-7, V-11 and V-20; Kona, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ...; Airspace Docket No. 10-AWP-20] Amendment of VOR Federal Airways V-1, V-7, V-11 and V-20; Kona, HI AGENCY..., HI; V-1, V-7, V-11 and V-20. The FAA is taking this action due to procedural changes requiring..., (76 FR 13082), amends VOR Federal Airways V-1, V-7 V-11 and V-20; Kona, HI. These VHF Omnidirectional...

  5. 76 FR 73760 - In the Matter of the Designation of Imad Fa'iz Mughniyah also Known as Imad Fayiz Mughniyah as a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... DEPARTMENT OF STATE [Public Notice 7699] In the Matter of the Designation of Imad Fa'iz Mughniyah also Known as Imad Fayiz Mughniyah as a Specially Designated Global Terrorist Pursuant to Section 1(b... amended (``the Order''), I hereby determine that the individual known as Imad Fa'iz Mughniyah, also known...

  6. Effects of human interleukins in the transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24 designed to assess the transcriptional activity of vitamin D receptor

    PubMed Central

    Bartonkova, Iveta; Kallay, Enikoe

    2018-01-01

    The role of vitamin D receptor (VDR) in immune responses has been broadly studied and it has been shown that activated VDR alters the levels of some interleukins (ILs). In this study, we studied the opposite, i.e. whether 13 selected pro-inflammatory and anti-inflammatory ILs influence the transcriptional activity of human VDR. The experimental models of choice were two human stably transfected gene reporter cell lines IZ-VDRE and IZ-CYP24, which were designed to evaluate the transcriptional activity of VDR. The gene reporter assays revealed inhibition of calcitriol-induced luciferase activity by IL-4 and IL-13, when 1 ng/mL of these two compounds decreased the effect of calcitriol down to 60% of the control value. Consistently, calcitriol-induced expression of CYP24A1 mRNA was also significantly decreased by IL-4 and IL-13. The expression of VDR and CYP27B1 mRNAs was not influenced by any of the 13 tested ILs. These data suggest possible cross-talk between the VDR signalling pathway and IL-4- and IL-13-mediated cell signalling. PMID:29489902

  7. [Historical notes on Infectious Diseases Hospital Francisco Javier Muñiz in Buenos Aires, Argentina].

    PubMed

    Laval, Enrique

    2012-08-01

    The Infectious Diseases Hospital Francisco Javier Muñiz, Buenos Aires, Argentina, is the oldest in Latin America. It is over 100 years old and has a history worthy of pride. It became known as "Hospital of the pests" and was preceded by the old House of Insulation, which served as a quarantine station during epidemics of cholera, yellow fever and smallpox. The new House of Insulation, built in the neighborhood of Parque Patricios ("Barracks Hospital"), was renamed in 1904 in memory of Francisco Javier Muñiz, a former military doctor, naturalist and paleontologist. Its technical name is "Porteño Care Centre and National Reference Regional Infectious-Contagious Disease". It receives numerous national and foreign undergraduate and postgraduate students in its Departments of Infectious Diseases and Respiratory Diseases.

  8. Indirect current control with separate IZ drop compensation for voltage source converters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kanetkar, V.R.; Dawande, M.S.; Dubey, G.K.

    1995-12-31

    Indirect Current Control (ICC) of boost type Voltage Source Converters (VSCs) using separate compensation of line IZ voltage drop is presented. A separate bi-directional VSC is used to produce the compensation voltage. This simplifies the ICC regulator scheme as the power flow is controlled through single modulation index. Experimental verification is provided for bi-directional control of the power flow.

  9. USEEIO v1.1-Matrices

    EPA Science Inventory

    This dataset provides the basic building blocks for the USEEIO v1.1 model and life cycle results per $1 (2013 USD) demand for all goods and services in the model in the producer's price (see BEA 2015). The methodology underlying USEEIO is described in Yang, Ingwersen et al., 2017...

  10. Response of lake water quality to wastewater inputs from land-based fish farm located on Yuvarlakçay Creek in Köyceğiz-Dalyan Specially Protected Area, Turkey.

    PubMed

    Taşeli, B K

    2009-10-01

    Köyceğiz Lake is located in the south-western part of Turkey. The area between the Köyceğiz Lake and the Mediterranean Sea is covered with four small lakes and several canals. The surroundings of the lake, canals and forests have a great potential as a reproduction areas for Mediterranean Sea turtles (Caretta caretta) and sheltering place for various animals. In the vicinity of this system there are agricultural areas and small settlements. In this region the most important economic activities are tourism and fisheries. However, the lake is currently threatened by pollution because of (1) non-point source pollution (agriculture); (2) point sources (land-based fish farms); (3) inefficient sewerage systems; (4) uncontrolled soil erosion in its drainage basin; (5) inappropriate flood control measures; and (6) channel traffic. This study evaluates the influence of its influent creeks namely Namnam and Yuvarlakçay Creek on the water quality of Köyceğiz Lake, mainly because the creeks are believed to be responsible for the major pollutant load reaching the lake. Accordingly, this study demonstrates (1) change in the water quality of Köyceğiz Lake from 2006 to 2007; (2) the water quality classification of the major influent creeks feeding Köyceğiz Lake; and (3) how land-based fish farm influences Yuvarlakçay Creek water quality in a Köyceğiz-Dalyan Specially Protected Area.

  11. High-resolution infrared studies of the v 10, v 11, v 14, and v 18 levels of [1.1.1]propellane

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kirkpatrick, Robynne W.; Masiello, Tony; Martin, Matthew A.

    2012-11-15

    This paper is a continuation of earlier work for which the high resolution infrared spectrum of [1.1.1]propellane was measured and its k and l structure resolved for the first time. Here we present results from an analysis of more than 16,000 transitions involving three fundamental bands v 10 (E'-A1'), v 11 (E'-A1'), v 14 (A2''-A1') and two difference bands (v 10- v 18) (E'-E'') and (v 11-v 18) (E'-E"). Additional information about v18 was also obtained from the difference band (v 15+v 18)-v 18 (E'-E") and the binary combination band (v 15+v 18) (E'-A1'). Through the use of the groundmore » state constants reported in an earlier paper [1], rovibrational constants have been determined for all the vibrational states involved in these bands. The rovibrational parameters for the v 18(E'') state were obtained from combination-differences and showed no need to include interactions with other states. The v 10(E') state analysis was also straight-forward, with only a weak Coriolis interaction with the levels of the v 14(A2'') state. The latter levels are much more affected by a strong Coriolis interaction with the levels of the nearby v 11(E') state and also by a small but significant interaction with another state, presumably the v16(E'') state, that is not directly observed. Gaussian calculations (B3LYP/cc-pVTZ) computed at the anharmonic level aided the analyses by providing initial values for many of the parameters. These theoretical results generally compare favorably with the final parameter values deduced from the spectral analyses. Finally, evidence was obtained for several level crossings between the rotational levels of the v 11 and v 14 states and, using a weak coupling term corresponding to a Δk = ±5, Δl = ∓1 matrix element, it was possible to find transitions from the ground state that, combined with transitions to the same upper state, give a value of C 0 = 0.1936519(4) cm -1. This result, combined with the value of B 0 = 0.28755833(14) cm-1 reported

  12. Controlling transformations in the assembly of polyoxometalate clusters: {Mo11V7}, {Mo17V8} and {Mo72V30}.

    PubMed

    Miras, Haralampos N; Ochoa, M Nieves Corella; Long, De-Liang; Cronin, Leroy

    2010-11-21

    The reaction of molybdate with vanadium(V) in the presence of sulfite anions is explored showing how, via cation control, stepwise assembly through the {Mo(11)V(7)} cluster yields a {M(25)} cluster-based compound, [Mo(VI)(11)V(V)(5)V(IV)(2)O(52)(μ(9)-SO(3))(Mo(VI)(6)V(V)O(22))](10-) (1a), which was first discovered using cryospray mass spectrometry, whereas switching the cation away from ammonium allows the direct formation of the spherical 'Keplerate' {Mo(72)V(30)} cluster.

  13. Apollo 11 Launched Via Saturn V Rocket

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle produced a holocaust of flames as it rose from its pad at Launch complex 39. The 363 foot tall, 6,400,000 pound rocket hurled the spacecraft into Earth parking orbit and then placed it on the trajectory to the moon for man's first lunar landing. The Saturn V was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard the spacecraft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module pilot; and Edwin E. Aldrin Jr., Lunar Module pilot. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  14. Apollo 11 Launched Via Saturn V Rocket

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Developed by the Marshall Space Flight Center (MSFC), the Saturn V vehicle produced a holocaust of flames as it rose from its pad at Launch complex 39. The 363 foot tall, 6,400,000 pound rocket hurled the spacecraft into Earth parking orbit and then placed it on the trajectory to the moon for man's first lunar landing. Aboard the spacecraft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  15. Apollo 11 Launched Via Saturn V Rocket

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle produced a holocaust of flames as it rose from its pad at Launch complex 39. The 363 foot tall, 6,400,000 pound rocket hurled the spacecraft into Earth parking orbit and then placed it on the trajectory to the moon for man's first lunar landing. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module pilot; and Edwin E. Aldrin Jr., Lunar Module pilot. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  16. On the road to DSM-V and ICD-11.

    PubMed

    Kupfer, David J; Regier, Darrel A; Kuhl, Emily A

    2008-11-01

    Development of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) has been ongoing since 1994, though official release will not occur for another 4 years. Potential revisions are being derived from multiple sources, including building on perceived limitations of DSM-IV; broad-based literature reviews; secondary and primary data analyses; and discussions between global members of the mental health community. The current focus on aligning DSM with the International Classification of Diseases-11 (ICD-11) speaks to the importance of creating a unified text that embraces cross-cutting issues of diagnostics, such as developmental, age-related, and cultural phenomena. International discourse is vital to this process and has been fostered by a National Institutes of Health-sponsored conference series on diagnosis-specific topics. From this series, the DSM-V Task Force developed the following set of revision principals to guide the efforts of the DSM-V Work Groups: grounding recommendations in empirical evidence; maintaining continuity with previous editions of DSM; removing a priori limitations on the amount of changes DSM-V may incur; and maintaining DSM's status as a living document. With work group formation complete, members are currently carrying out the research and revision recommendations proposed during the conference series. Ongoing activities include adding specialized advisors to each work group; completing literature reviews and planning data analyses; and forming study groups to discuss integration of cross-cutting issues (e.g., developmental lifespan factors; formation of diagnostic spectra). The road to DSM-V and ICD-11 has been challenging, but members continue to work diligently in their goal of constructing the most harmonious, scientifically sound, and clinically relevant DSM to date.

  17. 11-Step Total Synthesis of (−)-Maoecrystal V

    PubMed Central

    2016-01-01

    An expedient, practical, and enantioselective route to the highly congested ent-kaurane diterpene maoecrystal V is presented. This route, which has been several years in the making, is loosely modeled after a key pinacol shift in the proposed biosynthesis. Only 11 steps, many of which are strategic in that they build key skeletal bonds and incorporate critical functionalities, are required to access (−)-maoecrystal V. Several unique and unexpected maneuvers are featured in this potentially scalable pathway. Reevaluation of the biological activity calls into question the initial exuberance surrounding this natural product. PMID:27457680

  18. Apollo 11 Launched Via Saturn V Rocket - High Angle View

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle produced a holocaust of flames as it rose from its pad at Launch complex 39. The 363 foot tall, 6,400,000 pound rocket hurled the spacecraft into Earth parking orbit and then placed it on the trajectory to the moon. This high angle view of the launch was provided by a `fisheye' camera mounted on the launch tower. The Saturn V was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard the spacecraft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  19. αConotoxin ArIB[V11L,V16D] is a potent and selective antagonist at rat and human native α7 nicotinic acetylcholine receptors

    PubMed Central

    Innocent, Neal; Livingstone, Phil D.; Hone, Arik; Kimura, Atsuko; Young, Tracey; Whiteaker, Paul; McIntosh, J. Michael; Wonnacott, Susan

    2008-01-01

    A recently developed α-conotoxin, α-CtxArIB[V11L,V16D] is a potent and selective competitive antagonist at rat recombinant α7 nicotinic acetylcholine receptors (nAChRs), making it an attractive probe for this receptor subtype. α7 nAChRs are potential therapeutic targets that are widely expressed in both neuronal and non-neuronal tissues where they are implicated in a variety of functions. Here we evaluate this toxin at rat and human native nAChRs. Functional α7 nAChR responses were evoked by choline plus the allosteric potentiator PNU-120596 in rat PC12 cells and human SHSY5Y cells loaded with calcium indicators. α-CtxArIB[V11L,V16D] specifically inhibited α7 nAChR-mediated increases in Ca2+ in PC12 cells. Responses to other stimuli (5-iodo-A-85380, nicotine or KCl) that did not activate α7 nAChRs were unaffected. Human α7 nAChRs were also sensitive to α-CtxArIB[V11L,V16D]: ACh-evoked currents in X. laevis oocytes expressing human α7 nAChRs were inhibited by α-CtxArIB[V11L,V16D] (IC50 3.4 nM) in a slowly reversible manner, with full recovery taking 15 min. This is consistent with the timecourse of recovery from blockade of rat α7 nAChRs in PC12 cells. α-CtxArIB[V11L,V16D] inhibited human native α7 nAChRs in SHSY5Y cells, activated by either choline or AR-R17779 plus PNU-120596. Rat brain α7 nAChRs contribute to dopamine release from striatal minces: α-CtxArIB[V11L,V16D] (300 nM) selectively inhibited choline-evoked dopamine release without affecting responses evoked by nicotine that activates heteromeric nAChRs. This study establishes that α-CtxArIB[V11L,V16D] selectively inhibits human and rat native α7 nAChRs with comparable potency, making this a potentially useful antagonist for investigating α7 nAChR functions. PMID:18664588

  20. Harmonisation of ICD-11 and DSM-V: opportunities and challenges.

    PubMed

    First, Michael B

    2009-11-01

    Differences in the ICD-10 and DSM-IV definitions for the same disorder impede international communication and research efforts. The forthcoming parallel development of DSM-V and ICD-11 offers an opportunity to harmonise the two classifications. This paper aims to facilitate the harmonisation process by identifying diagnostic differences between the two systems. DSM-IV-TR criteria sets and the ICD-10 Diagnostic Criteria for Research were compared and categorised into those with identical definitions, those with conceptually based differences and those in which differences are not conceptually based and appear to be unintentional. Of the 176 criteria sets in both systems, only one, transient tic disorder, is identical. Twenty-one per cent had conceptually based differences and 78% had non-conceptually based differences. Harmonisation of criteria sets, especially those with non-conceptually based differences, should be prioritised in the DSM-V and ICD-11 development process. Prior experience with the DSM-IV and ICD-10 harmonisation effort suggests that for the process to be successful steps should be taken as early as possible.

  1. Calculations of stopping powers and inelastic mean free paths for 20 eV-20 keV electrons in 11 types of human tissue.

    PubMed

    Tan, Zhenyu; Liu, Wei

    2013-12-01

    Systematic calculations are performed for determining the stopping powers (SP) and inelastic mean free paths (IMFP) for 20 eV-20 keV electrons in 11 types of human tissue. The calculations are based on a dielectric model, including the Born-Ochkur exchange correction. The optical energy loss functions (OELF) are empirically evaluated, because of the lack of available experimental optical data for the 11 tissues under consideration. The evaluated OELFs are examined by the f-sum rule expected from the dielectric response theory, and by calculation of the mean excitation energy. The calculated SPs are compared with those for PMMA (polymethylmethacrylate, a tissue equivalent material) and liquid water. The SP and IMFP data presented here are the results for the 11 human tissues over the energy range of 20 eV-20 keV, and are of importance in radiotherapy planning and for studies of various radiation effects on human tissues. © 2013 Elsevier Ltd. All rights reserved.

  2. Apollo 11 Launched Via the Saturn V Rocket-High Angle View

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first lunar landing mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle produced a holocaust of flames as it rose from its pad at Launch complex 39. The 363 foot tall, 6,400,000 pound rocket hurled the spacecraft into Earth parking orbit and then placed it on the trajectory to the moon for man's first lunar landing. This high angle view of the launch was provided by a `fisheye' camera mounted on the launch tower. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module pilot; and Edwin E. Aldrin Jr., Lunar Module pilot. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  3. Questioning the Specificity of ASRS-v1.1 to Accurately Detect ADHD in Substance Abusing Populations

    ERIC Educational Resources Information Center

    Chiasson, Jean-Pierre; Stavro, Katherine; Rizkallah, Elie; Lapierre, Luc; Dussault, Maxime; Legault, Louis; Potvin, Stephane

    2012-01-01

    Objective: To assess the specificity of the Adult ADHD Self-Report Scale (ASRS-v1.1) in detecting ADHD among individuals with substance use disorders (SUDs). Method: A chart review of 183 SUD patients was conducted. Patients were screened for ADHD with the ASRS-v1.1 and were later assessed by a psychiatrist specialized in ADHD. Results: Among SUD…

  4. SModelS v1.1 user manual: Improving simplified model constraints with efficiency maps

    NASA Astrophysics Data System (ADS)

    Ambrogi, Federico; Kraml, Sabine; Kulkarni, Suchita; Laa, Ursula; Lessa, Andre; Magerl, Veronika; Sonneveld, Jory; Traub, Michael; Waltenberger, Wolfgang

    2018-06-01

    SModelS is an automatized tool for the interpretation of simplified model results from the LHC. It allows to decompose models of new physics obeying a Z2 symmetry into simplified model components, and to compare these against a large database of experimental results. The first release of SModelS, v1.0, used only cross section upper limit maps provided by the experimental collaborations. In this new release, v1.1, we extend the functionality of SModelS to efficiency maps. This increases the constraining power of the software, as efficiency maps allow to combine contributions to the same signal region from different simplified models. Other new features of version 1.1 include likelihood and χ2 calculations, extended information on the topology coverage, an extended database of experimental results as well as major speed upgrades for both the code and the database. We describe in detail the concepts and procedures used in SModelS v1.1, explaining in particular how upper limits and efficiency map results are dealt with in parallel. Detailed instructions for code usage are also provided.

  5. The Clinical Utility of ASRS-v1.1 for Identifying ADHD in Alcoholics Using PRISM as the Reference Standard.

    PubMed

    Reyes, Maria M; Schneekloth, Terry D; Hitschfeld, Mario J; Geske, Jennifer R; Atkinson, David L; Karpyak, Victor M

    2016-05-02

    The objective was to assess the clinical utility of the Adult ADHD Self-Report Scale (ASRS-v1.1) in identifying ADHD in alcoholics using the Psychiatric Research Interview for Substance and Mental Disorders (PRISM) as the diagnostic "gold standard." We performed a secondary analysis of data from 379 treatment-seeking alcoholics who completed the ASRS-v1.1 and the ADHD module of the PRISM. Data analysis included descriptive statistics. The prevalence of ADHD was 7.7% (95% CI = [5.4, 10.8]). The positive predictive value (PPV) of the ASRS-v1.1 was 18.1% (95% CI = [12.4, 25.7]) and the negative predictive value (NPV) was 97.6% (95% CI = [94.9, 98.9]). The ASRS-v1.1 demonstrated a sensitivity of 79.3% (95% CI = [61.6, 90.2]) and a specificity of 70.3% (95% CI = [65.3, 74.8]). The ASRS-v1.1 demonstrated acceptable sensitivity and specificity in a sample of treatment-seeking alcoholics when compared with the PRISM as the reference standard for ADHD diagnosis. © The Author(s) 2016.

  6. The BCL11A Transcription Factor Directly Activates RAG Gene Expression and V(D)J Recombination

    PubMed Central

    Lee, Baeck-seung; Dekker, Joseph D.; Lee, Bum-kyu; Iyer, Vishwanath R.; Sleckman, Barry P.; Shaffer, Arthur L.; Ippolito, Gregory C.

    2013-01-01

    Recombination-activating gene 1 protein (RAG1) and RAG2 are critical enzymes for initiating variable-diversity-joining (VDJ) segment recombination, an essential process for antigen receptor expression and lymphocyte development. The transcription factor BCL11A is required for B cell development, but its molecular function(s) in B cell fate specification and commitment is unknown. We show here that the major B cell isoform, BCL11A-XL, binds the RAG1 promoter and Erag enhancer to activate RAG1 and RAG2 transcription in pre-B cells. We employed BCL11A overexpression with recombination substrates in a cultured pre-B cell line as well as Cre recombinase-mediated Bcl11alox/lox deletion in explanted murine pre-B cells to demonstrate direct consequences of BCL11A/RAG modulation on V(D)J recombination. We conclude that BCL11A is a critical component of a transcriptional network that regulates B cell fate by controlling V(D)J recombination. PMID:23438597

  7. Werner von Braun relaxes after successful Apollo 11 Saturn V launch

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Wernher von Braun, director of the Marshall Space Flight Center, Huntsville, Alabama, relaxes after the successful launch of Apollo 11 astronauts Neil A. Armstrong, Michael Collins and Edwin Aldrin Jr. today. Their historic lunar landing mission began at 9:32 a.m. EDT, July 16, 1969, when an Apollo/Saturn V space vehicle lifted off from the spaceport's Launch Complex 39A.

  8. Post-repolarization refractoriness increases vulnerability to block and initiation of reentrant impulses in heterogeneous infarcted myocardium.

    PubMed

    Cabo, Candido

    2015-10-01

    Myocardial infarction causes remodeling of the tissue structure and the density and kinetics of several ion channels in the cell membrane. Heterogeneities in refractory period (ERP) have been shown to occur in the infarct border zone and have been proposed to lead to initiation of arrhythmias. The purpose of this study is to quantify the window of vulnerability (WV) to block and initiation of reentrant impulses in myocardium with ERP heterogeneities using computer simulations. We found that ERP transitions at the border between normal ventricular cells (NZ) with different ERPs are smooth, whereas ERP transitions between NZ and infarct border zone cells (IZ) are abrupt. The profile of the ERP transitions is a combination of electrotonic interaction between NZ and IZ cells and the characteristic post-repolarization refractoriness (PRR) of IZ cells. ERP heterogeneities between NZ and IZ cells are more vulnerable to block and initiation of reentrant impulses than ERP heterogeneities between NZ cells. The relationship between coupling intervals of premature impulses (V1V2) and coupling intervals between premature and first reentrant impulses (V2T1) at NZ/NZ and NZ/IZ borders is inverse (i.e. the longer the coupling intervals of premature impulses the shorter the coupling interval between the premature and first reentrant impulses); this is in contrast with the reported V1V2/V2T1 relationship measured during initiation of reentrant impulses in canine infarcted hearts which is direct. (1) ERP transitions at the NZ-IZ border are abrupt as a consequence of PRR; (2) PRR increases the vulnerability to block and initiation of reentrant impulses in heterogeneous myocardium; (3) V1V2/V2T1 relationships measured at ERP heterogeneities in the computer model and in experimental canine infarcts are not consistent. Therefore, it is likely that other mechanisms like micro and/or macro structural heterogeneities also contribute to initiation of reentrant impulses in infarcted hearts

  9. Divergent biophysical properties, gating mechanisms, and possible functions of the two skeletal muscle Ca(V)1.1 calcium channel splice variants.

    PubMed

    Tuluc, Petronel; Flucher, Bernhard E

    2011-12-01

    Voltage-gated calcium channels are multi-subunit protein complexes that specifically allow calcium ions to enter the cell in response to membrane depolarization. But, for many years it seemed that the skeletal muscle calcium channel Ca(V)1.1 is the exception. The classical splice variant Ca(V)1.1a activates slowly, has a very small current amplitude and poor voltage sensitivity. In fact adult muscle fibers work perfectly well even in the absence of calcium influx. Recently a new splice variant of the skeletal muscle calcium channel Ca(V)1.1e has been characterized. The lack of the 19 amino acid exon 29 in this splice variant results in a rapidly activating calcium channel with high current amplitude and good voltage sensitivity. Ca(V)1.1e is the dominant channel in embryonic muscle, where the expression of this high calcium-conducting Ca(V)1.1 isoform readily explains developmental processes depending on L-type calcium currents. Moreover, the availability of these two structurally similar but functionally distinct channel variants facilitates the analysis of the molecular mechanisms underlying the unique current properties of the classical Ca(V)1.1a channel.

  10. One-Pot Solvothermal Synthesis of Bi4V2O11 as A New Solar Water Oxidation Photocatalyst

    PubMed Central

    Jiang, Zaiyong; Liu, Yuanyuan; Li, Mengmeng; Jing, Tao; Huang, Baibiao; Zhang, Xiaoyang; Qin, Xiaoyan; Dai, Ying

    2016-01-01

    Bi4V2O11 was prepared via a one-pot solvothermal method and characterized via XRD, Raman, XPS, Electrochemical impedance spectroscopy. The as-prepared Bi4V2O11 sample displays excellent photocatalytic activity towards oxygen evolution under light irradiation. The hierarchical structure is in favour of the spatial separation of photogenerated electrons and holes. Furthermore, the internal polar field also plays a role in improving the charge separation. Both of the two results are responsible for excellent activity of O2 evolution. The resulting hierarchical Bi4V2O11 sample should be very promising photocatalyst for the application of photocatalytic O2 evolution in the future. PMID:26947126

  11. MREG V1.1 : a multi-scale image registration algorithm for SAR applications.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Eichel, Paul H.

    2013-08-01

    MREG V1.1 is the sixth generation SAR image registration algorithm developed by the Signal Processing&Technology Department for Synthetic Aperture Radar applications. Like its predecessor algorithm REGI, it employs a powerful iterative multi-scale paradigm to achieve the competing goals of sub-pixel registration accuracy and the ability to handle large initial offsets. Since it is not model based, it allows for high fidelity tracking of spatially varying terrain-induced misregistration. Since it does not rely on image domain phase, it is equally adept at coherent and noncoherent image registration. This document provides a brief history of the registration processors developed by Dept. 5962more » leading up to MREG V1.1, a full description of the signal processing steps involved in the algorithm, and a user's manual with application specific recommendations for CCD, TwoColor MultiView, and SAR stereoscopy.« less

  12. Palladium/IzQO-Catalyzed Coordination-Insertion Copolymerization of Ethylene and 1,1-Disubstituted Ethylenes Bearing a Polar Functional Group.

    PubMed

    Yasuda, Hina; Nakano, Ryo; Ito, Shingo; Nozaki, Kyoko

    2018-02-07

    Coordination-insertion copolymerization of ethylene with 1,1-disubstituted ethylenes bearing a polar functional group, such as methyl methacrylate (MMA), is a long-standing challenge in catalytic polymerization. The major obstacle for this process is the huge difference in reactivity of ethylene versus 1,1-disubstituted ethylenes toward both coordination and insertion. Herein we report the copolymerization of ethylene and 1,1-disubstituted ethylenes by using an imidazo[1,5-a]quinolin-9-olate-1-ylidene-supported palladium catalyst. Various types of 1,1-disubstituted ethylenes were successfully incorporated into the polyethylene chain. In-depth characterization of the obtained copolymers and mechanistic inferences drawn from stoichiometric reactions of alkylpalladium complexes with methyl methacrylate and ethylene indicate that the copolymerization proceeds by the same coordination-insertion mechanism that has been postulated for ethylene.

  13. Diagnostics for the optimization of an 11 keV inverse Compton scattering x-ray source

    NASA Astrophysics Data System (ADS)

    Chauchat, A.-S.; Brasile, J.-P.; Le Flanchec, V.; Nègre, J.-P.; Binet, A.; Ortega, J.-M.

    2013-04-01

    In a scope of a collaboration between Thales Communications & Security and CEA DAM DIF, 11 keV Xrays were produced by inverse Compton scattering on the ELSA facility. In this type of experiment, X-ray observation lies in the use of accurate electron and laser beam interaction diagnostics and on fitted X-ray detectors. The low interaction probability between < 100 μm width, 12 ps [rms] length electron and photon pulses requires careful optimization of pulse spatial and temporal covering. Another issue was to observe 11 keV X-rays in the ambient radioactive noise of the linear accelerator. For that, we use a very sensitive detection scheme based on radio luminescent screens.

  14. Absolute cross sections for electronic excitation of condensed tetrahydrofuran (THF) by 11-16 eV electrons.

    PubMed

    Lemelin, V; Bass, A D; Cloutier, P; Sanche, L

    2016-11-07

    Absolute cross section (CS) data on the interaction of low energy electrons with DNA and its molecular constituents are required as input parameters in Monte-Carlo type simulations, for several radiobiological applications. Previously [V. Lemelin et al., J. Chem. Phys. 144, 074701 (2016)], we measured absolute vibrational CSs for low-energy electron scattering from condensed tetrahydrofuran, a convenient surrogate for the deoxyribose. Here we report absolute electronic CSs for energy losses of between 6 and 11.5 eV, by electrons with energies between 11 and 16 eV. The variation of these CSs with incident electron energy shows no evidence of transient anion states, consistent with theoretical and other experimental results, indicating that initial electron capture leading to DNA strand breaks occurs primarily on DNA bases or the phosphate group.

  15. Inactivated and live bivalent fowl adenovirus (FAdV8b + FAdV11) breeder vaccines provide broad-spectrum protection in chicks against inclusion body hepatitis (IBH).

    PubMed

    Gupta, Ashish; Popowich, Shelly; Ojkic, Davor; Kurukulasuriya, Shanika; Chow-Lockerbie, Betty; Gunawardana, Thushari; Goonewardene, Kalhari; Karunarathna, Ruwani; Ayalew, Lisanework E; Ahmed, Khawaja Ashfaque; Tikoo, Suresh K; Willson, Philip; Gomis, Susantha

    2018-01-29

    Fowl adenovirus (FAdV) is comprised of five species (A to E) and 12 serotypes (1-7, 8a, 8b, 9-11). Inclusion body hepatitis (IBH) is caused by FAdV-7, 8a, 8b (species E) and FAdV-2 and 11 (species D). Commercial vaccines against IBH are not available in Canada. Autogenous FAdV broiler breeder vaccines are now used in some areas where outbreaks of IBH are occurring. The objective of this study was to evaluate the efficacy of a bivalent (species D and E) live and an inactivated FAdV broiler breeder vaccine in protecting broiler chicks against IBH through maternal antibody (MtAb) transfer. FAdV seronegative broiler breeders (n = 300/group) received either a live or inactivated bivalent (FAdV-8b-SK + FAdV-11-1047) vaccine. The live vaccine (1 × 10 4 TCID 50 of each virus/bird) was given orally once at 16 weeks of age and the inactivated vaccine (1 × 10 6 TCID 50 of each virus + 20% Emulsigen D) was given intramuscularly at 16 and 19 weeks of age. Controls (n = 150) were given saline orally. The inactivated vaccine group was boosted 3 weeks later with the same vaccine. Neutralizing antibodies (NAb) in sera (n = 10) were detected at 19, 22, 30 and 48 weeks of age. NAb were able to neutralize various FAdV serotypes within species D and E. Mean NAb were similar in the both live and killed vaccine groups at 19, 30 and 48 weeks and ranged from 2.4 to 3.7 log 10 . Approximately 26 ± 7% of MtAbs were passively transferred through eggs to day-old chicks. Progeny challenged with a lethal dose (1 × 10 7 TCID 50 /bird intramuscularly) of FAdV-8b-SK, FAdV-11-1047, or FAdV-2-685 (n = 90/group) at 14 days post-hatch (dph) showed 98-100% protection in broiler chicks to homologous or heterologous FAdV challenges. Our data suggests that a bivalent live and an inactivated FAdV vaccine are equally effective and have the potential for the control of IBH. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels.

    PubMed

    Tuluc, Petronel; Benedetti, Bruno; Coste de Bagneaux, Pierre; Grabner, Manfred; Flucher, Bernhard E

    2016-06-01

    Alternative splicing of the skeletal muscle CaV1.1 voltage-gated calcium channel gives rise to two channel variants with very different gating properties. The currents of both channels activate slowly; however, insertion of exon 29 in the adult splice variant CaV1.1a causes an ∼30-mV right shift in the voltage dependence of activation. Existing evidence suggests that the S3-S4 linker in repeat IV (containing exon 29) regulates voltage sensitivity in this voltage-sensing domain (VSD) by modulating interactions between the adjacent transmembrane segments IVS3 and IVS4. However, activation kinetics are thought to be determined by corresponding structures in repeat I. Here, we use patch-clamp analysis of dysgenic (CaV1.1 null) myotubes reconstituted with CaV1.1 mutants and chimeras to identify the specific roles of these regions in regulating channel gating properties. Using site-directed mutagenesis, we demonstrate that the structure and/or hydrophobicity of the IVS3-S4 linker is critical for regulating voltage sensitivity in the IV VSD, but by itself cannot modulate voltage sensitivity in the I VSD. Swapping sequence domains between the I and the IV VSDs reveals that IVS4 plus the IVS3-S4 linker is sufficient to confer CaV1.1a-like voltage dependence to the I VSD and that the IS3-S4 linker plus IS4 is sufficient to transfer CaV1.1e-like voltage dependence to the IV VSD. Any mismatch of transmembrane helices S3 and S4 from the I and IV VSDs causes a right shift of voltage sensitivity, indicating that regulation of voltage sensitivity by the IVS3-S4 linker requires specific interaction of IVS4 with its corresponding IVS3 segment. In contrast, slow current kinetics are perturbed by any heterologous sequences inserted into the I VSD and cannot be transferred by moving VSD I sequences to VSD IV. Thus, CaV1.1 calcium channels are organized in a modular manner, and control of voltage sensitivity and activation kinetics is accomplished by specific molecular mechanisms

  17. Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels

    PubMed Central

    Tuluc, Petronel; Benedetti, Bruno; Coste de Bagneaux, Pierre; Grabner, Manfred

    2016-01-01

    Alternative splicing of the skeletal muscle CaV1.1 voltage-gated calcium channel gives rise to two channel variants with very different gating properties. The currents of both channels activate slowly; however, insertion of exon 29 in the adult splice variant CaV1.1a causes an ∼30-mV right shift in the voltage dependence of activation. Existing evidence suggests that the S3–S4 linker in repeat IV (containing exon 29) regulates voltage sensitivity in this voltage-sensing domain (VSD) by modulating interactions between the adjacent transmembrane segments IVS3 and IVS4. However, activation kinetics are thought to be determined by corresponding structures in repeat I. Here, we use patch-clamp analysis of dysgenic (CaV1.1 null) myotubes reconstituted with CaV1.1 mutants and chimeras to identify the specific roles of these regions in regulating channel gating properties. Using site-directed mutagenesis, we demonstrate that the structure and/or hydrophobicity of the IVS3–S4 linker is critical for regulating voltage sensitivity in the IV VSD, but by itself cannot modulate voltage sensitivity in the I VSD. Swapping sequence domains between the I and the IV VSDs reveals that IVS4 plus the IVS3–S4 linker is sufficient to confer CaV1.1a-like voltage dependence to the I VSD and that the IS3–S4 linker plus IS4 is sufficient to transfer CaV1.1e-like voltage dependence to the IV VSD. Any mismatch of transmembrane helices S3 and S4 from the I and IV VSDs causes a right shift of voltage sensitivity, indicating that regulation of voltage sensitivity by the IVS3–S4 linker requires specific interaction of IVS4 with its corresponding IVS3 segment. In contrast, slow current kinetics are perturbed by any heterologous sequences inserted into the I VSD and cannot be transferred by moving VSD I sequences to VSD IV. Thus, CaV1.1 calcium channels are organized in a modular manner, and control of voltage sensitivity and activation kinetics is accomplished by specific molecular

  18. Publications - PDF 98-37A v. 1.1 | Alaska Division of Geological &

    Science.gov Websites

    main content DGGS PDF 98-37A v. 1.1 Publication Details Title: Geologic map of the Tanana A-1 and A-2 ., 1998, Geologic map of the Tanana A-1 and A-2 quadrangles, central Alaska: Alaska Division of Geological & Other Oversized Sheets Maps & Other Oversized Sheets Sheet 1 Preliminary geologic map of the

  19. 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Johnson, Reed F., E-mail: johnsonreed@mail.nih.gov; Bagci, Ulas; Center for Research in Computer Vision

    Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10{sup 6} PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a humanmore » anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment. - Highlights: • MERS-CoV Jordan-n3/2012 challenge of rhesus monkeys results in a mild disease. • CT can be used to monitor disease progression to aid models of human disease. • Treatment with the human monoclonal antibody 3B11-N resulted in decreased disease.« less

  20. Global Carbon Project: the 2014 Global Carbon Budget (V.1.0, issued Sept. 2014 and V.1.1, issued May 2015)

    DOE Data Explorer

    Le Quere, C. [University of East Anglia, Norwich UK; Moriarty, R. [University of East Anglia, Norwich UK; Andrew, R. M. [Univ. of Oslo (Norway); Peters, G. P. [Univ. of Oslo (Norway); Boden, T. A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States), Carbon Dioxide Information Analysis Center (CDIAC)

    2014-01-01

    The GCP provides an annual report of carbon dioxide emissions, land and ocean sinks and accumulation in the atmosphere, incorporating data from multiple research institutes from around the world. More information can be found at www.globalcarbonproject.org/carbonbudget. Each year's Global Carbon Budget is a collaborative effort of the global carbon cycle science community coordinated by the Global Carbon Project. The landing page for this dataset includes links to the 2014 report, V. 1.0, issued Sept2014 and V.1.1, issued May 2015. Many links to older years versions are also available from this landing page.

  1. Gamma rays from the de-excitation of C-12 resonance 15.11 MeV and C-12 resonance 4.44 MeV as probes of energetic particle spectra

    NASA Technical Reports Server (NTRS)

    Crannell, C. J.; Crannell, H.; Ramaty, R.

    1977-01-01

    The flux of 15.11 MeV gamma rays relative to the flux 4.44 MeV gamma rays was calculated from measured cross sections for excitation of the corresponding states of C-12 and from experimental determinations of the branching ratios for direct de-excitation of these states to the ground state. Because of the difference in threshold energies for excitation of these two levels, the relative intensities in the two lines are particularly sensitive to the spectral distribution of energetic particles which excite the corresponding nuclear levels. For both solar and cosmic emission, the observability of the 15.11 MeV line is expected to be enhances by low source-background continuum in this energy range.

  2. [Study cost/effectiveness of portable fridges in the mobile unit of emergencies of Alcañiz (Teruel)].

    PubMed

    Mir Ramos, Eduardo; Martínez Tofé, Jesús; Castro Salanova, Rafael; Azón López, Esther; Corcuera Cantabrana, Ana; Sancho Pellicer, Antonio

    2012-09-01

    The maintenance of cold chain can result difficult in Emergency Mobil Units that's why the aim of this study is to value the effectiveness of portable fridges with/without compressor and its cost-effectiveness by a computer simulation. This descriptive, transversal and cost effectiveness analysis was developed in two Emergency Mobil Units of 061 Aragón of Alcañiz (Teruel) along a year. The results showed that in the fridge with compressor, the 93'8% of the temperatures was between 2 and 8 degrees C, where as in the fridge without compressor was of the 35,7%.The global and specific cost effectiveness ratio of the fridge with and without compressor were of 0,063 and 7,411 and of 0,080 and 147,55 respectively. Fridge with compressor was more cost-effective, amortizing quickly its initial cost. This fridge had a better and more efficient thermoregulation what supposed a better conservation of drugs and lower costs, according to the model of simulation.

  3. Reactions of rhenium(V) and molybdenum(V) oxypentahalides with 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ashurova, N.Kh.; Yakubov, K.G.

    1993-11-01

    The author studied complexation reactions of rhenium(V) and molybdenum(V) with a macrocyclic ligand 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane (Tet a). The authors found that in hydrohalic acid medium, the onium complexes [H{sub 2}(Tet a)][EOX{sub 5}] are formed, with E = Re, Mo; X = Cl, Br. Reactions of [EOX{sub 5}]{sup 2{minus}} with (Tet a) in nitrometane yield complexes of molecular and cation types [EO(Tet a)Cl{sub 3}] and [EO(Tet a)Br]Br{sub 2}. Composition and structure of the obtained compounds are established by elemental analysis, conductometry, and mid- and far-IR spectroscopy.

  4. Influences of Hardware Implementation on a High Speed Digital Adaptive Filter Using the Residue Number System.

    DTIC Science & Technology

    1982-04-01

    vgWTE(6,*5)1i4IT VALUL FUk 1(,L’ 34b bqEAL(5.e)IA(IL) 3047 CUivTIN’UE 348 iU 3u Iz2#K 3 4 4 Q0 30 11 350 IA(I#L SIA (1lpj 351 .5V COIINUE 3S? 4V RTURN...34 706 130 CON INUE 707L 70o Ces,.PRINT X-AXIS SCALL VALUES 709 c 710 DO 150 IXMs~f1Z 711 IF (1T N 1) to01 140 712 )XSCAL(E’M SKmI400UFO(IXM-1l) 713

  5. Characterization of Graphene Stripper Foils in 11-MeV Cyclotrons

    NASA Astrophysics Data System (ADS)

    Korenev, Sergey; Dishman, Rick; Yebra, Alberto; Meshcheryakov, Nikolay; Smirnov, Ilya; Pavlovsky, Igor; Fink, Richard

    An experimental study of the use of graphene as an extractor (stripper) foil in the 11-MeV Siemens Eclipse Cyclotron is discussed in this paper. The main advantage of graphene is its high thermal conductivity compared to that of amorphous carbon films. Graphene also has significant mechanical strength. The lifetime of the graphene foils under proton bombardment exceeded 16,000 μAh. Graphene-based stripper foils demonstrated a significant increase in the transmission factor (defined as the ratio of the beam current on the target to the beam current on the stripper foil), which was approximately 90%. Fabrication of the graphene-based foils is discussed. The pros and cons of using the graphene material as a stripper foil in cyclotrons are analyzed.

  6. 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.

    PubMed

    Johnson, Reed F; Bagci, Ulas; Keith, Lauren; Tang, Xianchun; Mollura, Daniel J; Zeitlin, Larry; Qin, Jing; Huzella, Louis; Bartos, Christopher J; Bohorova, Natasha; Bohorov, Ognian; Goodman, Charles; Kim, Do H; Paulty, Michael H; Velasco, Jesus; Whaley, Kevin J; Johnson, Joshua C; Pettitt, James; Ork, Britini L; Solomon, Jeffrey; Oberlander, Nicholas; Zhu, Quan; Sun, Jiusong; Holbrook, Michael R; Olinger, Gene G; Baric, Ralph S; Hensley, Lisa E; Jahrling, Peter B; Marasco, Wayne A

    2016-03-01

    Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment. Published by Elsevier Inc.

  7. Cross section asymmetry of two-body carbon disintegration 12C (γ , p)11B with polarized photons at energy 40-50 MeV

    NASA Astrophysics Data System (ADS)

    Burdeinyi, D.; Brudvik, J.; Fissum, K.; Ganenko, V.; Hansen, K.; Isaksson, L.; Livingston, K.; Lundin, M.; Nilsson, B.; Schroder, B.

    2017-01-01

    The cross section asymmetry of 12C (γ ,p01)11B and 12C (γ ,p2-6)11B reactions has been studied at the energy range 40-55 MeV, using linearly polarized tagged photons of the MAX-lab facility. The asymmetry of the 12C (γ ,p01)11B processes, which assume the one-body mechanism of the reaction, is Σ ≈ 0.82 ± 0.05 for photon energies 45-50 MeV. The asymmetry for the 12C (γ ,p2-6)11B reactions, which produce a maximum at excitation energy ∼ 6 MeV, is Σ ≈ 0.53 ± 0.13 for a photon energy 49 MeV. It is close to the asymmetry of reaction of the free deuteron photodisintegration, and can be resulted from the two-body mechanism of the photon absorption.

  8. CONFERENCE Proceedings of the computer Aided System Design and Simulation (50th) Held in Cesme/Ismir, Turkey on 22-25 May 1990 (Systeme de Conception Aide par Ordinateur et Simulation)

    DTIC Science & Technology

    1990-05-01

    vital problem. During flight conditions a sensor, or a combination of sensors might undergo a failure, causing the loss of sensor signals that are...by solving the optimization problem max I k - k I(Z 00 (55) d(zk) e n V~ l where k denotes the nominal sensor gains and I1.11 denotes the weighted I...the Weapon System. Parameters like volume and weight have to be approximately defined at the begining of this phase. It is equally important to obtain

  9. E&V Guidebook, Version 1.1

    DTIC Science & Technology

    1989-08-15

    checklist 14.1] Chapter 3, Language-related issues, extracts from the Ada language reference manua! [,_D 1982] those features exp!icitly a!owcd to vay...welcome. Please send comments electronically (preferred) to szymansk~aja;po.sei.cmu.edu, or by regular mail to Mr. Raymond Szymanski , AFWAL/AAAF, Wright...of Tool Features for the Ada Programming Support Environment (APSE) 4-3 4.3 E&V Report: DoD APSE Analysis 4-4 4.4 Classification Schema/E&V Taxonomy

  10. Superlattice Structures, Electronic Properties, and Spin Dynamics of the Partially Cu-Extracted Phase for the Composite Crystal System CuxV4O11

    NASA Astrophysics Data System (ADS)

    Onoda, Masashige; Tamura, Asato

    2017-02-01

    The crystal structures, electronic properties, and spin dynamics of CuxV4O11 with 1.2 ≤ x < 2, classified as the partially Cu-extracted phase for the composite crystal system, are explored through measurements of x-ray four-circle diffraction, electrochemistry, electrical resistivity, thermoelectric power, magnetization, and electron paramagnetic resonance. This system has superlattice structures mainly ascribed to the partial ordering of Cu ions. Cu1.78V4O11 is triclinic with space group Pbar{1} and the double supercell of the V4O11 substructure of the composite crystal. The significantly Cu-extracted crystal Cu1.40V4O11 has a quadruple supercell with space group P1. The electron transport for V ions is nonmetallic owing to the polaronic nature and/or phonon softening and to the random potential of Cu ions. The Curie-Weiss-type paramagnetism basically originates from the Cu2+ chain coordinated octahedrally, and the EPR relaxation at low temperatures is understood through the exchange mechanism for the dipole-dipole and anisotropic exchange interactions. The near absence of paramagnetic behaviors of V4+ ions might be due to the spin-singlet ladder model or alternating-exchange chain model depending on the superlattice structure and valence distribution. The electrochemical performance of Li rechargeable batteries using this superlattice system is about 300 A h kg-1 at voltages above 2 V.

  11. Relationship between innervation zone width and mean muscle fiber conduction velocity during a sustained isometric contraction.

    PubMed

    Ye, X; Beck, T W; Wages, N P

    2015-03-01

    To examine the relationship between the biceps brachii muscle innervation zone (IZ) width and the mean muscle fiber conduction velocity (MFCV) during a sustained isometric contraction. Fifteen healthy men performed a sustained isometric elbow flexion exercise at their 60% maximal voluntary contraction (MVC) until they could not maintain the target force. Mean MFCV was estimated through multichannel surface electromyographic recordings from a linear electrode array. Before exercise, IZ width was quantified. Separate non-parametric one-way analyses of variance (ANOVAs) were used to examine whether there was a difference in each mean MFCV variable among groups with different IZ width. In addition, separate bivariate correlations were also performed to examine the relationships between the IZ width and the mean MFCV variables during the fatiguing exercise. There was a significant difference in the percent decline of mean MFCV (%ΔMFCV) among groups with different IZ width (χ(2) (3)=11.571, p=0.009). In addition, there was also a significant positive relationship between the IZ width and the %ΔMFCV (Kendall's tau= 0.807; p<0.001). We believe that such relationship is likely influenced by both muscle fiber size and the muscle fiber type composition.

  12. Nosological status and definition of schizophrenia: Some considerations for DSM-V and ICD-11.

    PubMed

    Tandon, Rajiv; Maj, Mario

    2008-12-01

    Although dementia praecox or schizophrenia has been considered a unique disease entity for the past century, its definitions and boundaries have varied over this period. In this article, we examine the changing conceptualization of schizophrenia over the past 100 years and make some recommendations with regards to its definition in DSM-V and ICD-11. We summarize clinical features of schizophrenia in terms of symptomatology, course, and outcome. We examine factors that lead to changing definitions of a disorder such as schizophrenia, with specific reference to the evolution of its definition from DSM-1 (American Psychiatric Association, Washington, DC, 1952) to the current DSM-IV-TR. Efforts to elucidate the etiology and pathophysiology of schizophrenia have been hampered by its imprecise definition and continuing transformations in its conceptualization. The definition of schizophrenia, at any given time, has been influenced by available diagnostic tools and treatments, other clinical considerations, extant knowledge and scientific paradigms. It is now clear that schizophrenia does not represent a single disease with a unitary etiology or pathogenetic process. Despite limitations in the concept, however, alternative approaches thus far have been unsuccessful in better defining the syndrome of schizophrenia or its component entities. Whereas changing definitions of schizophrenia might impede research into its nature and development of more effective treatments, only a better understanding of schizophrenia can lead to its more precise definition. We consider the implications of our observations for DSM-V and ICD-11 definitions of schizophrenia and summarize some emerging preliminary recommendations. Copyright © 2008 Elsevier B.V. All rights reserved.

  13. A candidate V/STOL research aircraft design concept using an S-3A aircraft and 2 Pegasus 11 engines

    NASA Technical Reports Server (NTRS)

    Lampkin, B. A.

    1980-01-01

    A candidate V/STOL research aircraft concept which uses an S-3A airframe and two Pegasus 11 engines was studied to identify a feasible V/STOL national flight facility that could be obtained at the lowest possible cost for the demonstration of V/STOL technology, inflight simulation, and flight research. The rationale for choosing the configuration, a description of the configuration, and the capability of a fully developed aircraft are discussed.

  14. Validity and reliability of the attention deficit hyperactivity disorder self-report scale (ASRS-v1.1) in a clinical sample with eating disorders.

    PubMed

    Carlucci, Samantha; Ivanova, Iryna; Bissada, Hany; Tasca, Giorgio A

    2017-08-01

    Individuals with eating disorders (EDs) commonly experience comorbid attention deficit hyperactivity disorder (ADHD). The shared features of EDs and ADHD, such as inattention, impulsivity and hyperactivity, may exacerbate ED symptomatology and pose challenges to treatment. It is important to screen patients with EDs for symptoms of ADHD to optimize their treatment outcomes. However, the psychometrics of common measures of ADHD have not yet been examined within an ED population. An example of such a measure is the ADHD self-report scale (ASRS-v1.1) symptom checklist, which identifies the presence of ADHD symptoms. This study reports a psychometric study of the ASRS-v1.1 in a clinical sample of 500 adults with an ED. A confirmatory factor analysis indicated the ASRS-v1.1 maintained its two-factor structure of inattention and impulsivity/hyperactivity. The item loadings demonstrated path invariance across ED diagnostic groups indicating construct validity. Further, the subscales exhibited good internal consistency and they were significantly correlated with other measures of impulsivity indicating convergent validity. The ED sample had significantly higher mean scores than published nonclinical norms indicating predictive validity, but the ASRS-v1.1 scores were not significantly different among ED diagnostic groups. Results suggest the ASRS-v1.1 is a valid and reliable screening tool for identifying symptoms of ADHD among adults seeking treatment for ED. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Imprinted zeolite modified carbon paste electrode as a potentiometric sensor for uric acid

    NASA Astrophysics Data System (ADS)

    Khasanah, Miratul; Widati, Alfa Akustia; Fitri, Sarita Aulia

    2016-03-01

    Imprinted zeolite modified carbon paste electrode (carbon paste-IZ) has been developed and applied to determine uric acid by potentiometry. The imprinted zeolite (IZ) was synthesized by the mole ratio of uric acid/Si of 0.0306. The modified electrode was manufactured by mass ratio of carbon, IZ and solid paraffin was 40:25:35. The modified electrode had shown the measurement range of 10-5 M to 10-2 M with Nernst factor of 28.6 mV/decade, the detection limit of 5.86 × 10-6 M and the accuracy of 95.3 - 105.0%. Response time of the electrode for uric acid 10-5 M - 10-2 M was 25 - 44 s. The developed electrode showed the high selectivity toward uric acid in the urea matrix. Life time of the carbon paste-IZ electrode was 10 weeks.

  16. 76 FR 13082 - Amendment of VOR Federal Airways V-1, V-7, V-11 and V-20; Kona, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... V-20; Kona, HI AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends four VHF Omnidirectional Range (VOR) Federal airways in the vicinity of Kona, HI; V- 1, V-7... Keahole Airport property Kailua-Kona, HI. This will enhance the management of aircraft operations over...

  17. Emotional disorders: cluster 4 of the proposed meta-structure for DSM-V and ICD-11.

    PubMed

    Goldberg, D P; Krueger, R F; Andrews, G; Hobbs, M J

    2009-12-01

    The extant major psychiatric classifications DSM-IV, and ICD-10, are atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis would be greatly enhanced by an understanding of risk factors and clinical manifestations. In an effort to group mental disorders on the basis of aetiology, five clusters have been proposed. This paper considers the validity of the fourth cluster, emotional disorders, within that proposal. We reviewed the literature in relation to 11 validating criteria proposed by a Study Group of the DSM-V Task Force, as applied to the cluster of emotional disorders. An emotional cluster of disorders identified using the 11 validators is feasible. Negative affectivity is the defining feature of the emotional cluster. Although there are differences between disorders in the remaining validating criteria, there are similarities that support the feasibility of an emotional cluster. Strong intra-cluster co-morbidity may reflect the action of common risk factors and also shared higher-order symptom dimensions in these emotional disorders. Emotional disorders meet many of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster.

  18. P- V- T equation of state of CaAl4Si2O11 CAS phase

    NASA Astrophysics Data System (ADS)

    Gréaux, Steeve; Nishiyama, Norimasa; Kono, Yoshio; Irifune, Tetsuo; Gautron, Laurent

    2011-09-01

    The thermoelastic parameters of the CAS phase (CaAl4Si2O11) were examined by in situ high-pressure (up to 23.7 GPa) and high-temperature (up to 2,100 K) synchrotron X-ray diffraction, using a Kawai-type multi-anvil press. P- V data at room temperature fitted to a third-order Birch-Murnaghan equation of state (BM EOS) yielded: V 0,300 = 324.2 ± 0.2 Å3 and K 0,300 = 164 ± 6 GPa for K' 0,300 = 6.2 ± 0.8. With K' 0,300 fixed to 4.0, we obtained: V 0,300 = 324.0 ± 0.1 Å3 and K 0,300 = 180 ± 1 GPa. Fitting our P- V- T data with a modified high-temperature BM EOS, we obtained: V 0,300 = 324.2 ± 0.1 Å3, K 0,300 = 171 ± 5 GPa, K' 0,300 = 5.1 ± 0.6 (∂ K 0 ,T /∂ T) P = -0.023 ± 0.006 GPa K-1, and α0 ,T = 3.09 ± 0.25 × 10-5 K-1. Using the equation of state parameters of the CAS phase determined in the present study, we calculated a density profile of a hypothetical continental crust that would contain ~10 vol% of CaAl4Si2O11. Because of the higher density compared with the coexisting minerals, the CAS phase is expected to be a plunging agent for continental crust subducted in the transition zone. On the other hand, because of the lower density compared with lower mantle minerals, the CAS phase is expected to remain buoyant in the lowermost part of the transition zone.

  19. Alpha-induced reactions on selenium between 11 and 15 MeV

    NASA Astrophysics Data System (ADS)

    Fiebiger, Stefan; Slavkovská, Zuzana; Giesen, Ulrich; Göbel, Kathrin; Heftrich, Tanja; Heiske, Annett; Reifarth, René; Schmidt, Stefan; Sonnabend, Kerstin; Thomas, Benedikt; Weigand, Mario

    2017-07-01

    The production of 77,79,85,85m Kr and 77Br via the reaction Se(α ,x) was investigated between {E}α =11 and 15 MeV using the activation technique. The irradiation of natural selenium targets on aluminum backings was conducted at the Physikalisch-Technische Bundesanstalt (PTB) in Braunschweig, Germany. The spectroscopic analysis of the reaction products was performed using a high-purity germanium detector located at PTB and a low energy photon spectrometer detector at the Goethe University Frankfurt, Germany. Thick-target yields were determined. The corresponding energy-dependent production cross sections of 77,79,85,85m Kr and 77Br were calculated from the thick-target yields. Good agreement between experimental data and theoretical predictions using the TALYS-1.6 code was found.

  20. Lithium Vanadium Oxide (Li 1.1V 3O 8) Coated with Amorphous Lithium Phosphorous Oxynitride (LiPON): Role of Material Morphology and Interfacial Structure on Resulting Electrochemistry

    DOE PAGES

    Zhang, Qing; Kercher, Andrew K.; Veith, Gabriel M.; ...

    2017-05-16

    In the present work, lithium vanadium oxide (Li 1.1V 3O 8) particles synthesized at two different temperatures were coated with an amorphous lithium phosphorous oxynitride (LiPON) film for the first time, and the effects of the LiPON coating on the electrochemistry of the Li 1.1V 3O 8 materials with different morphologies were systematically investigated by comparing uncoated Li 1.1V 3O 8 and Li 1.1V 3O 8 coated with LiPON of various thicknesses. Galvanostatic discharge-charge cycling revealed increased functional capacity for the LiPON-coated materials. Post-cycling electrochemical impedance spectroscopy showed that LiPON-coated Li 1.1V 3O 8 materials developed less interfacial resistance withmore » extended cycling, rationalized by vanadium migration into the LiPON coating seen by electron energy loss spectra. Post-mortem quantitative analysis of the anodes revealed more severe vanadium dissolution for the more irregularly shaped Li 1.1V 3O 8 materials with less LiPON coverage. Thus, this study highlights the specific benefits and limitations of LiPON coatings for stabilizing a moderate voltage Li 1.1V 3O 8 cathode material under extended cycling in liquid electrolyte, and describes a generally applicable approach for comprehensive characterization of a composite electroactive material which can be used to understand interfacial transport properties in other functional systems.« less

  1. Lithium Vanadium Oxide (Li 1.1V 3O 8) Coated with Amorphous Lithium Phosphorous Oxynitride (LiPON): Role of Material Morphology and Interfacial Structure on Resulting Electrochemistry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Qing; Kercher, Andrew K.; Veith, Gabriel M.

    In the present work, lithium vanadium oxide (Li 1.1V 3O 8) particles synthesized at two different temperatures were coated with an amorphous lithium phosphorous oxynitride (LiPON) film for the first time, and the effects of the LiPON coating on the electrochemistry of the Li 1.1V 3O 8 materials with different morphologies were systematically investigated by comparing uncoated Li 1.1V 3O 8 and Li 1.1V 3O 8 coated with LiPON of various thicknesses. Galvanostatic discharge-charge cycling revealed increased functional capacity for the LiPON-coated materials. Post-cycling electrochemical impedance spectroscopy showed that LiPON-coated Li 1.1V 3O 8 materials developed less interfacial resistance withmore » extended cycling, rationalized by vanadium migration into the LiPON coating seen by electron energy loss spectra. Post-mortem quantitative analysis of the anodes revealed more severe vanadium dissolution for the more irregularly shaped Li 1.1V 3O 8 materials with less LiPON coverage. Thus, this study highlights the specific benefits and limitations of LiPON coatings for stabilizing a moderate voltage Li 1.1V 3O 8 cathode material under extended cycling in liquid electrolyte, and describes a generally applicable approach for comprehensive characterization of a composite electroactive material which can be used to understand interfacial transport properties in other functional systems.« less

  2. ART: Surveying the Local Universe at 2-11 keV

    NASA Technical Reports Server (NTRS)

    O'Dell, S. L.; Ramsey, B. D.; Adams, M. L.; Brandt, W. N.; Bubarev, M. V.; Hassinger, G.; Pravlinski, M.; Predehl, P.; Romaine, S. E.; Swartz, D. A.; hide

    2008-01-01

    The Astronomical Rontgen Telescope (ART) is a medium-energy x-ray telescope system proposed for the Russian-led mission Spectrum Rontgen-Gamma (SRG). Optimized for performance over the 2-11-keV band, ART complements the softer response of the SRG prime instrument-the German eROSITA x-ray telescope system. The anticipated number of ART detections is 50,000-with 1,000 heavily-obscured (N(sub H)> 3x10(exp 23)/sq cm) AGN-in the SRG 4-year all-sky survey, plus a comparable number in deeper wide-field (500 deg(sup 2) total) surveys. ART's surveys will provide a minimally-biased, nearly-complete census of the local Universe in the medium-energy x-ray band (including Fe-K lines), at CCD spectral resolution. During long (approx.100-ks) pointed observations, ART can obtain statistically significant spectral data up to about 15 keY for bright sources and medium-energy x-ray continuum and Fe-K-line spectra of AGN detected with the contemporaneous NuSTAR hard-x-ray mission.

  3. Innervation zone shift at different levels of isometric contraction in the biceps brachii muscle.

    PubMed

    Piitulainen, Harri; Rantalainen, Timo; Linnamo, Vesa; Komi, Paavo; Avela, Janne

    2009-08-01

    Experiments were carried out to examine whether innervation zone (IZ) location remains stable at different levels of isometric contraction in the biceps brachii muscle (BB), and to determine how the proximity of the IZ affects common surface electromyography (sEMG) parameters. Twelve subjects performed maximal (MVC) and submaximal voluntary isometric contractions at 10%, 20%, 30%, 40%, 50% and 75% of MVC. sEMG signals were recorded with a 13 rows x 5 columns grid of electrodes from the short head of BB. The IZ shifted in the proximal direction by up to 2.4 cm, depending upon the subject and electrode column. The mean shift of all the columns was 0.6+/-0.4 cm (10% vs. 100% MVC, P<0.001). This shift biased the average values of mean frequency (+21.8+/-9.9 Hz, P<0.001), root mean square (-0.16+/-0.15 mV, P<0.05) and conduction velocity (-1.15+/-0.93 m/s, P<0.01) in the channels immediately proximal to the IZ. The shift in IZ could be explained by shortening of the muscle fibers, and thus lengthening of the (distal) tendon due to increasing force. These results underline the importance of individual investigation of IZ locations before the placement of sEMG electrodes, even in isometric contractions.

  4. Statistical Processing Methods for Polarimetric Imagery

    DTIC Science & Technology

    2008-09-01

    c ) G.G. Stokes portrait normalized bounds 5 10 15 20 0 0.2 0.4 0.6 0.8 1 N or m al iz ed v ar ia nc e Number of frames average...Bar target Stokes bounds 0 10 20 30 40 50 60 10 −2 10 0 10 2 10 4 10 6 N or m al iz ed v ar ia nc e Channel spacing S 0 S 1 S 2 ( c ) PC board...0.6 0.7 iteration N M S E multichannel single channel ( c ) S2 Figure 4.7: NMSE quartiles for the Simulated Stokes

  5. 12C(n , 2 n )11C cross section from threshold to 26.5 MeV

    NASA Astrophysics Data System (ADS)

    Yuly, M.; Eckert, T.; Hartshaw, G.; Padalino, S. J.; Polsin, D. N.; Russ, M.; Simone, A. T.; Brune, C. R.; Massey, T. N.; Parker, C. E.; Fitzgerald, R.; Sangster, T. C.; Regan, S. P.

    2018-02-01

    The 12C(n ,2 n )11C cross section was measured from just below threshold to 26.5 MeV using the Pelletron accelerator at Ohio University. Monoenergetic neutrons, produced via the 3H(d ,n )4He reaction, were allowed to strike targets of polyethylene and graphite. Activation of both targets was measured by counting positron annihilations resulting from the β+ decay of 11C. Annihilation gamma rays were detected, both in coincidence and singly, using back-to-back NaI detectors. The incident neutron flux was determined indirectly via 1H(n ,p ) protons elastically scattered from the polyethylene target. Previous measurements fall into upper and lower bands; the results of the present measurement are consistent with the upper band.

  6. Magnetization and Hall effect under high pressure in NaV 6O 11

    NASA Astrophysics Data System (ADS)

    Naka, T.; Matsumoto, T.; Kanke, Y.; Murata, K.

    1995-02-01

    We have investigated the pressure dependences of magnetization and the Hall coefficient in the ferromagnetic vanadium oxide NaV 6O 11 up to 1.2 GPa. Structural transitions (hexagonal-hexagonal-orthorhombic) occur at TH = 245 K and TL = 35 K at ambient pressure. Meanwhile, the susceptibility obeys the Curie-Weiss law X = C/( T - θ) with antiferromagnetic correlation of θ < 0 at T > TH, with ferromagnetic correlation of θ < 0 at T < TH. The spontaneous magnetization appears below Tc = 64.2 K. With increasing pressure, Tc and magnetization M( T < Tc) decrease, while TH increases. The sign of the Hall coefficient changes continuously (negative-positive-negative) at around T ≈ 170 K and 75 K.

  7. A simple thick target for production of 89Zr using an 11MeV cyclotron

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Link, Jeanne M.; Krohn, Kenneth A.; O'Hara, Matthew J.

    2017-04-01

    The growing interest but limited availability of 89Zr for PET led us to test targets for the 89(p,n) reaction. The goal was an easily constructed target for an 11 MeV Siements cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90 degree foil tolerated 41 microAmp without damage and produced ~800 MBq/hr, >20 mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons.

  8. Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates Recombinase Activating Gene Expression and V(D)J Recombination

    PubMed Central

    Lee, Baeck-Seung; Lee, Bum-Kyu; Iyer, Vishwanath R.; Sleckman, Barry P.; Shaffer, Arthur L.; Ippolito, Gregory C.

    2017-01-01

    ABSTRACT Recombination activating gene 1 (RAG1) and RAG2 are critical enzymes for initiating variable-diversity-joining [V(D)J] segment recombination, an essential process for antigen receptor expression and lymphocyte development. The BCL11A transcription factor is required for B cell and plasmacytoid dendritic cell (pDC) development, but its molecular function(s) in early B cell fate specification and commitment is unknown. We show here that the major B cell isoform, BCL11A-XL, binds directly to the RAG1 promoter as well as directly to regulatory regions of transcription factors previously implicated in both B cell and pDC development to activate RAG1 and RAG2 gene transcription in pro- and pre-B cells. We employed BCL11A overexpression with recombination substrates to demonstrate direct consequences of BCL11A/RAG modulation on V(D)J recombination. We conclude that BCL11A is a critical component of a transcriptional network that regulates B cell fate by controlling V(D)J recombination. PMID:29038163

  9. Study of Pilot Visual Information Requirements for Navy Vertical Take-Off and Landing Capability Development,

    DTIC Science & Technology

    1979-06-01

    PAGE VI-102 z C - - a. .2 0 a0@ o £o 0 ~ 0 Bp11 zo -cn D0 >4- *~I T? T! 0F MIL I "’I* % I H il U_ IZ 7.. NAEC-MISC-91-0R019 S- - - - AGE VI-103 9: Z~t 0... 81019 . X0v9 ’ 90* .olollf Mf*tat dotte deck C00040’ 2 AmŔe’ 09 Engageco 3 Re LO 1 ttd 6-co 1-c 00 0;t-nC1 n aec" STANDARD L*IGOOIN EO9JPWFNT OVERHEAD

  10. B11-: a moving subnanoscale tank tread

    NASA Astrophysics Data System (ADS)

    Wang, Ying-Jin; Zhao, Xiao-Yun; Chen, Qiang; Zhai, Hua-Jin; Li, Si-Dian

    2015-09-01

    We present a concept that an elongated, planar boron cluster can serve as a ``tank tread'' at the sub-nanometer scale, a novel propulsion system for potential nanomachines. Density functional calculations at the PBE0/6-311+G* level for the global-minimum B11-C2v (1A1) and B11C2v (2B2) structures along the soft in-plane rotational mode allow the identification of their corresponding B11-C2v and B11C2v transition states, with small rotational energy barriers of 0.42 and 0.55 kcal mol-1, respectively. The energy barriers are refined to 0.35 and 0.60 kcal mol-1 at the single-point CCSD(T) level, suggesting that the clusters are structurally fluxional at room temperature. Molecular dynamics simulations show that B11- and B11 behave exactly like a tank tread, in which the peripheral B9 ring rotates almost freely around the B2 core. A full turn of rotation may be accomplished in around 2 ps. In contrast to molecular wheels or Wankel motors, the peripheral boron atoms in the tank tread behave as a flexible chain gliding around, rather than as a rigid wheel rotation. This finding is beyond imagination, which expands the concepts of molecular wheels and Wankel motors.We present a concept that an elongated, planar boron cluster can serve as a ``tank tread'' at the sub-nanometer scale, a novel propulsion system for potential nanomachines. Density functional calculations at the PBE0/6-311+G* level for the global-minimum B11-C2v (1A1) and B11C2v (2B2) structures along the soft in-plane rotational mode allow the identification of their corresponding B11-C2v and B11C2v transition states, with small rotational energy barriers of 0.42 and 0.55 kcal mol-1, respectively. The energy barriers are refined to 0.35 and 0.60 kcal mol-1 at the single-point CCSD(T) level, suggesting that the clusters are structurally fluxional at room temperature. Molecular dynamics simulations show that B11- and B11 behave exactly like a tank tread, in which the peripheral B9 ring rotates almost freely

  11. A simple thick target for production of 89Zr using an 11 MeV cyclotron

    PubMed Central

    Link, Jeanne M.; Krohn, Kenneth A.; O’Hara, Matthew J.

    2017-01-01

    The growing interest but limited availability of 89Zr for PET led us to test targets for the 89Y(p,n) reaction. The goal was an easily constructed target for an 11 MeV Siemens cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90° foil tolerated 41 μA without damage and produced ~800 MBq/h, > 20 mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons. PMID:28187357

  12. The 12C(n, 2n)11C cross section from threshold to 26.5 MeV

    PubMed Central

    Eckert, T.; Hartshaw, G.; Padalino, S. J.; Polsin, D. N.; Russ, M.; Simone, A. T.; Brune, C. R.; Massey, T. N.; Parker, C. E.; Fitzgerald, R.; Sangster, T. C.; Regan, S. P.

    2018-01-01

    The 12C(n, 2n)11C cross section was measured from just below threshold to 26.5 MeV using the Pelletron accelerator at Ohio University. Monoenergetic neutrons, produced via the 3H(d,n)4He reaction, were allowed to strike targets of polyethylene and graphite. Activation of both targets was measured by counting positron annihilations resulting from the β+ decay of 11C. Annihilation gamma rays were detected, both in coincidence and singly, using back-to-back NaI detectors. The incident neutron flux was determined indirectly via 1H(n,p) protons elastically scattered from the polyethylene target. Previous measurements fall into upper and lower bands; the results of the present measurement are consistent with the upper band. PMID:29732443

  13. The 12C(n, 2n)11C cross section from threshold to 26.5 MeV.

    PubMed

    Yuly, M; Eckert, T; Hartshaw, G; Padalino, S J; Polsin, D N; Russ, M; Simone, A T; Brune, C R; Massey, T N; Parker, C E; Fitzgerald, R; Sangster, T C; Regan, S P

    2018-02-01

    The 12 C(n, 2n) 11 C cross section was measured from just below threshold to 26.5 MeV using the Pelletron accelerator at Ohio University. Monoenergetic neutrons, produced via the 3 H(d,n) 4 He reaction, were allowed to strike targets of polyethylene and graphite. Activation of both targets was measured by counting positron annihilations resulting from the β + decay of 11 C. Annihilation gamma rays were detected, both in coincidence and singly, using back-to-back NaI detectors. The incident neutron flux was determined indirectly via 1 H(n,p) protons elastically scattered from the polyethylene target. Previous measurements fall into upper and lower bands; the results of the present measurement are consistent with the upper band.

  14. Subaqueous hot springs in Köyceğiz Lake, Dalyan Channel and Fethiye-Göcek Bay (SW Turkey): Locations, chemistry and origins

    NASA Astrophysics Data System (ADS)

    Avşar, Özgür; Avşar, Ulaş; Arslan, Şebnem; Kurtuluş, Bedri; Niedermann, Samuel; Güleç, Nilgün

    2017-10-01

    In this study, horizontal temperature measurements along organized grids have been used to detect subaqueous hot springs. The study area, located in the southwest of Turkey and comprised of Köyceğiz Lake, Dalyan Channel and Fethiye-Göcek Bay, was scanned by measuring temperatures horizontally, 2-3 m above the bottom of the lake or sea. After analyzing the temperature data along the grids, the locations with anomalous temperature values were detected, and divers headed here for further verification. Accordingly, among these anomalies, the divers confirmed seven of them as subaqueous hot springs. Three of these hot springs are located in the Köyceğiz Lake, three of them are located in the Dalyan Channel and one hot spring is located in the Fethiye-Göcek Bay. At the locations where temperature anomalies were detected, the divers collected samples directly from the subaqueous hot spring using a syringe-type sampler. We evaluated these water samples together with samples collected from hot and cold springs on land and from local rivers, lakes and the sea, with an aim to generate a conceptual hydrogeochemical model of the geothermal system in the study area. This model predicts that rainwater precipitating in the highlands percolates through fractures and faults into the deeper parts of the Earth's crust, here it is heated and ascends through the sea bottom via buried faults. Pervious carbonate nappes that are underlain and overlain by impervious rocks create a confined aquifer. The southern boundary of the Carbonate-Marmaris nappes is buried under alluvium and/or sea/lake water bodies and this phenomenon determines whether hot springs occur on land or subaqueous. The chemical and isotopic properties of the hot springs point to seawater mixing at deep levels. Thus, the mixing most probably occurs while the water is ascending through the faults and fractures. The gas geochemistry results reveal that the lowest mantle He contributions occur in the samples from K

  15. Energy Dispersive X-ray Diffraction (EDXRD) of Li1.1V3O8 Electrochemical Cell

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Qing; Bruck, Andrea M.; Bock, David C.

    2017-01-01

    ABSTRACT In this study, we conducted the first energy dispersive x-ray diffraction (EDXRD) experiments on Li/Li 1.1V 3O 8coin cells discharged to different lithiation levels in order to investigate the phase transitions upon electrochemical reduction. The phase transformation from layered Li-poor α to Li-rich α to defect rock-salt β phase was confirmed with cells of different lithiation stages. No spatial localization of phase formation was observed throughout the cathodes under the conditions of this measurement.

  16. Energy Dispersive X-ray Diffraction (EDXRD) of Li1.1V3O8 Electrochemical Cell

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Qing; Bruck, Andrea M.; Bock, David C.

    ABSTRACT In this study, we conducted the first energy dispersive x-ray diffraction (EDXRD) experiments on Li/Li 1.1V 3O 8coin cells discharged to different lithiation levels in order to investigate the phase transitions upon electrochemical reduction. The phase transformation from layered Li-poor α to Li-rich α to defect rock-salt β phase was confirmed with cells of different lithiation stages. No spatial localization of phase formation was observed throughout the cathodes under the conditions of this measurement.

  17. Measurement of the transverse four-dimensional beam rms-emittance of an intense uranium beam at 11.4 MeV/u

    NASA Astrophysics Data System (ADS)

    Xiao, C.; Groening, L.; Gerhard, P.; Maier, M.; Mickat, S.; Vormann, H.

    2016-06-01

    Knowledge of the transverse four-dimensional beam rms-parameters is essential for applications that involve lattice elements that couple the two transverse degrees of freedom (planes). Usually pepper-pots are used for measuring these beam parameters. However, for ions their application is limited to energies below 150 keV/u. This contribution is on measurements of the full transverse four-dimensional second-moments beam matrix of high intensity uranium ions at an energy of 11.4 MeV/u. The combination of skew quadrupoles with a slit/grid emittance measurement device has been successfully applied.

  18. Externalizing disorders: cluster 5 of the proposed meta-structure for DSM-V and ICD-11.

    PubMed

    Krueger, R F; South, S C

    2009-12-01

    The extant major psychiatric classifications DSM-IV and ICD-10 are purportedly atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis is greatly enhanced by an understanding of the etiology. In an attempt to group mental disorders on the basis of etiology, five clusters have been proposed. We consider the validity of the fifth cluster, externalizing disorders, within this proposal. We reviewed the literature in relation to 11 validating criteria proposed by the Study Group of the DSM-V Task Force, in terms of the extent to which these criteria support the idea of a coherent externalizing spectrum of disorders. This cluster distinguishes itself by the central role of disinhibitory personality in mental disorders spread throughout sections of the current classifications, including substance dependence, antisocial personality disorder and conduct disorder. Shared biomarkers, co-morbidity and course offer additional evidence for a valid cluster of externalizing disorders. Externalizing disorders meet many of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster.

  19. Measurement of the 7Li(γ,t)4He reaction between 4 and 11 MeV

    NASA Astrophysics Data System (ADS)

    Pain, Steven; Matei, Catalin; Munch, Michael; Brune, Carl; Febbraro, Michael; Karwowski, Hugon; Walter, David; P-10-16 Experiment Collaboration

    2017-09-01

    The discrepancy in the primordial 7Li abundance, as derived from stellar observations and nucleosynthesis calculations at WMAP baryonic density, is sensitive to alpha capture rates on 3He and 3H. The 3He(α, γ)7Be reaction has been well studied over a wide range of energies, but for 3H(α, γ)7Li discrepancies exist in measurements below ECM = 1 MeV, and limited data above 1.2 MeV do not sufficiently constrain the contribution from higher-lying resonances at astrophysical energies. To contribute to the understanding of this process we have measured cross sections and angular distributions for the time-reversed 7Li(γ, α)3H reaction. The measurement was performed at the HIGS facility at the Triangle Universities Nuclear Laboratory (TUNL) using quasi-monoenergetic ( 3 % resolution) photon energies between 4 and 11 MeV. Tritons and alpha particles were detected in silicon detectors of SIDAR surrounding the 7Li target, and the beam intensity was monitored using multiple techniques. Details of the measurement, including the challenges of charged-particle measurements with gamma-ray beams, and preliminary results will be presented. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics.

  20. All Prime Contract Awards by State or Country, Place, and Contractor. Part 14 (Akron, New York-Wilson, North Carolina)

    DTIC Science & Technology

    1990-01-01

    i4 i-N( 000U or- L-4ɘ 0-4 0- ɘin L-- )CO 1-00 V) 11 034 Was00 Mtn0 40 00 (90 NO inO -400 -100 ,-411 I.1 . : I Iz o I of 103 - 110 nin I -4 -I 0 in w...4 U- 103 (0< If 0 0 0000 00000000 0 00 00000000 0 : ID ::O4I 00 00 000400 000000000 00 0. ~0 000000000o 0M If M (40 < I-4 4 14 44 .. ൴ -4-4 -i1--i -4...xzz xzzzzzzz MO) :: ax ZZ OZZZZ* a) z o z Q)Zzzz* 4)z O)zz* wzzzzzzz I moo it Z z z Z z I z z z 4D I moo 11 0) QC>00 11 cn a a) PD In In ",4 *4D-qamr-m

  1. Continuous desulfurization and bacterial community structure of an integrated bioreactor developed to treat SO2 from a gas stream.

    PubMed

    Lin, Jian; Li, Lin; Ding, Wenjie; Zhang, Jingying; Liu, Junxin

    2015-11-01

    Sulfide dioxide (SO2) is often released during the combustion processes of fossil fuels. An integrated bioreactor with two sections, namely, a suspended zone (SZ) and immobilized zone (IZ), was applied to treat SO2 for 6months. Sampling ports were set in both sections to investigate the performance and microbial characteristics of the integrated bioreactor. SO2 was effectively removed by the synergistic effect of the SZ and IZ, and more than 85% removal efficiency was achieved at steady state. The average elimination capacity of SO2 in the bioreactor was 2.80g/(m(3)·hr) for the SZ and 1.50g/(m(3)·hr) for the IZ. Most SO2 was eliminated in the SZ. The liquid level of the SZ and the water content ratio of the packing material in the IZ affected SO2 removal efficiency. The SZ served a key function not only in SO2 elimination, but also in moisture maintenance for the IZ. The desired water content in IZ could be feasibly maintained without any additional pre-humidification facilities. Clone libraries of 16S rDNA directly amplified from the DNA of each sample were constructed and sequenced to analyze the community composition and diversity in the individual zones. The desulfurization bacteria dominated both zones. Paenibacillus sp. was present in both zones, whereas Ralstonia sp. existed only in the SZ. The transfer of SO2 to the SZ involved dissolution in the nutrient solution and biodegradation by the sulfur-oxidizing bacteria. This work presents a potential biological treatment method for waste gases containing hydrophilic compounds. Copyright © 2015. Published by Elsevier B.V.

  2. Bilateral Comparison of 1 V and 10 V Standards between the NIMT (Thailand) and the BIPM October to December 2014 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Stock, M.; Pimsut, S.

    2015-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the National Institute of Metrology (Thailand), NIMT, was carried out from October to December 2014. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPMA (ZA) and BIPM6 (Z6), were transported by freight to NIMT and back to BIPM. At NIMT, the reference standard for DC voltage is a Josephson Voltage Standard. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at NIMT, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned toDC voltage standards by NIMT, at the level of 1.018 V and 10 V, at NIMT, UNIMT, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 23 November 2014. UNIMT - UBIPM = 0.16 mV; uc = 0.14 mV, at 1 V UNIMT - UBIPM = - 0.03 mV; uc = 0.11 mV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NIMT, based on KJ-90, and the uncertainty related to the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  3. 76 FR 72093 - Amendment of VOR Federal Airways V-81, V-89, and V-169 in the Vicinity of Chadron, NE

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ...-1016; Airspace Docket No. 11-ACE-6] RIN 2120-AA66 Amendment of VOR Federal Airways V-81, V-89, and V... airways V-81, V-89, and V-169 in the vicinity of Chadron, Nebraska. The FAA is taking this action because the Chadron VOR distance measuring equipment (DME), included as part of the V-81, V-89, and V-169...

  4. E&V (Evaluation and Validation) Reference Manual, Version 1.1

    DTIC Science & Technology

    1988-10-20

    E&V. This model will allow the user to arrive at E&V techniques through many different paths, and provides a means to extract useful information...electronically (preferred) to szymansk@ajpo.sei.cmu.edu or by regular mail to Mr. Raymond Szymanski , AFWAL/AAAF, Wright Patterson AFB, OH 45433-6543. ES-2 E&V...1, 1-3 illustrate the types of infor- mation to be extracted from each document. Chapter 2 provides a more detailed description of the structure and

  5. The R-matrix investigation of 8Li(α, n)11B reaction below 6 MeV

    NASA Astrophysics Data System (ADS)

    Kilic, Ali Ihsan; Muecher, Dennis; Garret, Paul; Svensson, Carl

    2017-09-01

    The investigation of cross sections for the 8Li(α, n)11B reaction has important impact for both primordial nucleosynthesis in the inhomogeneous models as well as constraining the physical conditions characterizing the r-process. However, there are large discrepancies existing between inclusive and exclusive measurements of the cross section below 3 MeV. The R-Matrix technique is a powerful tool for the analysis of the nuclear data for the purpose of extracting level information of compound nucleus 12B and extrapolation of the astrophysical S-Factor to Gamow energies. We have applied the R-matrix calculations for the 8Li(α, n)11B reaction and will present results for both the reaction rates and the partial S-factor. Combining the direct reaction contribution with the results from our R-matrix calculations, we can well describe the experimental data from the inclusive measurements. However, new experiments are needed in order to understand the role of neutron detection close to the threshold, for which we describe our experimental plans at ISAC, TRIUMF, using the newly developed DESCANT array.

  6. Groundwars Analysis of the Laser Warning Receiver (LWR). Phase 2

    DTIC Science & Technology

    1992-06-02

    Advanced Field Artillery Systems, ATTN: SFAE-ASM-.AF, Picatinny Arsenal, NJ 07801 Future Armored Resupply Vehicle-Ammunition, ATTN: SFAE-ASM- FR , Picatinny...I I i I I uW I I D I IA ZL I I I 1 3 Tu W- WI IJJ 1 I i I li I x i l l l l I WW WW WWW LJ IzI I U- . I3 1I Z I I I I I n I IzT--:-)I I W0 1 1 1 I " I...Lfi I ll I 0 cc c) -- w z .1 00 LU I -4 , I . .. . . . IJ ’L coJ,< E ..: :.... ...... Z EDX -J - CI) zV I I S . .1 w w V OL__ z.I Lr >- 0 !- 0

  7. Study of 11Li and 10,11Be nuclei through elastic scattering and breakup reactions

    NASA Astrophysics Data System (ADS)

    Gaidarov, M. K.; Lukyanov, V. K.; Kadrev, D. N.; Zemlyanaya, E. V.; Antonov, A. N.; Lukyanov, K. V.; Spasova, K.

    2016-01-01

    The hybrid model of the microscopic optical potential (OP) is applied to calculate the 11Li+p, 10,11Be+p, and 10,11Be+12C elastic scattering cross sections at energies E < 100 MeV/nucleon. The OP's contain the folding-model real part (ReOP) with the direct and exchange terms included, while its imaginary part (ImOP) is derived within the high-energy approximation (HEA) theory. For the 11Li+p elastic scattering, the microscopic large-scale shell model (LSSM) density of 11Li is used, while the density distributions of 10,11Be nuclei obtained within the quantum Monte Carlo (QMC) model and the generator coordinate method (GCM) are utilized to calculate the microscopic OPs and cross sections of elastic scattering of these nuclei on protons and 12C. The depths of the real and imaginary parts of OP are fitted to the elastic scattering data, being simultaneously adjusted to reproduce the true energy dependence of the corresponding volume integrals. Also, the cluster models, in which 11Li consists of 2n-halo and the 9Li core having its own LSSM form of density and 11Be consists of a n-halo and the 10Be core, are adopted. Within the latter, we give predictions for the longitudinal momentum distributions of 9Li fragments produced in the breakup of 11Li at 62 MeV/nucleon on a proton target. It is shown that our results for the diffraction and stripping reaction cross sections in 11Be scattering on 9Be, 93Nb, 181Ta, and 238U targets at 63 MeV/nucleon are in a good agreement with the available experimental data.

  8. 77 FR 42625 - Modification of VOR Federal Airways V-10, V-12, and V-508 in the Vicinity of Olathe, KS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ...-0055; Airspace Docket No. 11-ACE-12] RIN 2120-AA66 Modification of VOR Federal Airways V-10, V-12, and V-508 in the Vicinity of Olathe, KS AGENCY: Federal Aviation Administration (FAA), DOT. [[Page 42626

  9. Vitual screening and binding mode elucidation of curcumin analogues on Cyclooxygenase-2 using AYO_COX2_V1.1 protocol

    NASA Astrophysics Data System (ADS)

    Mulatsari, E.; Mumpuni, E.; Herfian, A.

    2017-05-01

    Curcumin is yellow colored phenolic compounds contained in Curcuma longa. Curcumin is known to have biological activities as anti-inflammatory, antiviral, antioxidant, and anti-infective agent [1]. Synthesis of curcumin analogue compounds has been done and some of them had biological activity like curcumin. In this research, the virtual screening of curcumin analogue compounds has been conducted. The purpose of this research was to determine the activity of these compounds as selective Cyclooxygenase-2inhibitors in in-silico. Binding mode elucidation was made by active and inactive representative compounds to see the interaction of the amino acids in the binding site of the compounds. This research used AYO_COX2_V.1.1, a structure-based virtual screening protocol (SBVS) that has been validated by Mumpuni E et al, 2014 [2]. AYO_COX2_V.1.1 protocol using a variety of integrated applications such as SPORES, PLANTS, BKchem, OpenBabel and PyMOL. The results of virtual screening conducted on 49 curcumin analogue compounds obtained 8 compounds with 4 active amino acid residues (GLY340, ILE503, PHE343, and PHE367) that were considered active as COX-2 inhibitor.

  10. Isochronal annealing studies on 1.1 MeV Fe ion irradiated RAFM steel using variable energy slow positron beam

    NASA Astrophysics Data System (ADS)

    Ramachandran, Renjith; David, C.; Rajaraman, R.; Abhaya, S.; Panigrahi, B. K.; Amarendra, G.

    2017-05-01

    Indian Reduced Activation Ferritic Martensitic steel is irradiated with 1.1 MeV Fe ions to a dose of 0.1 dpa at room temperature. The positron annihilation study showed a decrease in S-parameter with annealing temperature due to vacancy annealing. A complete defect recovery is observed beyond 1073 K. The linear nature of (S, W) correlation plot shows that only one kind of defect is present throughout the annealing temperature.

  11. 3-D Synthetic Microstructure Generation with Ellipsoid Particles

    DTIC Science & Technology

    2016-09-27

    MATLAB scripts in Appendix A, Appendix B, and Appendix C by using 3 -D matrices, where the background is 0 and the particle is 1. For the 3 -D ellipses, it...iy(iy== 0 )=image_size(2); nlo = z0 - floor(diam/2); nhi = z0 + ceil(diam/2)-1; iz = mod(nlo:nhi,image_size( 3 ));iz(iz== 0 )=image_size( 3 ); Itest = logical...z0 + ceil(diam/2)-1; iz = mod(nlo:nhi,image_size( 3 )); iz(iz== 0 )=image_size( 3 ); Itest = logical(I(ix,iy,iz)); if sum(Itest(I_ellipse)) == 0 Itest

  12. 76 FR 82114 - Amendment of VOR Federal Airways V-320 and V-440; Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ...-1014; Airspace Docket No. 11-AAL-19] RIN 2120-AA66 Amendment of VOR Federal Airways V-320 and V-440... amends two VHF Omnidirectional Range (VOR) Federal airways in Alaska, V-320 and V-440, due to the... proposed rulemaking to amend VOR Federal airways V-320 and V-440 in Alaska, due to the relocation of the...

  13. Routine production of copper-64 using 11.7MeV protons

    NASA Astrophysics Data System (ADS)

    Jeffery, C. M.; Smith, S. V.; Asad, A. H.; Chan, S.; Price, R. I.

    2012-12-01

    Reliable production of copper-64 (64Cu) was achieved by irradiating enriched nickel-64 (64Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 ± 3.0 mg) was electroplated onto an Au disc (125μm × 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40μA. Copper isotopes (60,61,62,64Cu) were separated from target nickel and cobalt isotopes (55,57,61Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The 64Ni target material was recovered and reused. The 64Cu production rate was 1.46±0.3MBq/μA.hr/mg64Ni(n = 10) (with a maximum of 2.6GBq of 64Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the 64Cu was 98.7 ± 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of 64Cu was determined by ICP-MS and by titration with Diamsar to be 28.9±13.0GBq/μmol[0.70±0.35Ci/μmol]/(μA.hr/mg64Ni)(n = 10) and 13.1±12.0GBq/μmol[0.35±0.32Ci/μmol]/(μA.hr/mg64Ni)(n = 9), respectively; which are in agreement, however, further work is required.

  14. Likelihood analysis of the pMSSM11 in light of LHC 13-TeV data

    NASA Astrophysics Data System (ADS)

    Bagnaschi, E.; Sakurai, K.; Borsato, M.; Buchmueller, O.; Citron, M.; Costa, J. C.; De Roeck, A.; Dolan, M. J.; Ellis, J. R.; Flächer, H.; Heinemeyer, S.; Lucio, M.; Martínez Santos, D.; Olive, K. A.; Richards, A.; Spanos, V. C.; Suárez Fernández, I.; Weiglein, G.

    2018-03-01

    We use MasterCode to perform a frequentist analysis of the constraints on a phenomenological MSSM model with 11 parameters, the pMSSM11, including constraints from ˜ 36/fb of LHC data at 13 TeV and PICO, XENON1T and PandaX-II searches for dark matter scattering, as well as previous accelerator and astrophysical measurements, presenting fits both with and without the (g-2)_μ constraint. The pMSSM11 is specified by the following parameters: 3 gaugino masses M_{1,2,3}, a common mass for the first-and second-generation squarks m_{\\tilde{q}} and a distinct third-generation squark mass m_{\\tilde{q}_3}, a common mass for the first-and second-generation sleptons m_{\\tilde{ℓ }} and a distinct third-generation slepton mass m_{\\tilde{τ }}, a common trilinear mixing parameter A, the Higgs mixing parameter μ , the pseudoscalar Higgs mass M_A and tan β . In the fit including (g-2)_μ , a Bino-like \\tilde{χ }^01 is preferred, whereas a Higgsino-like \\tilde{χ }^01 is mildly favoured when the (g-2)_μ constraint is dropped. We identify the mechanisms that operate in different regions of the pMSSM11 parameter space to bring the relic density of the lightest neutralino, \\tilde{χ }^01, into the range indicated by cosmological data. In the fit including (g-2)_μ , coannihilations with \\tilde{χ }^02 and the Wino-like \\tilde{χ }^± 1 or with nearly-degenerate first- and second-generation sleptons are active, whereas coannihilations with the \\tilde{χ }^02 and the Higgsino-like \\tilde{χ }^± 1 or with first- and second-generation squarks may be important when the (g-2)_μ constraint is dropped. In the two cases, we present χ ^2 functions in two-dimensional mass planes as well as their one-dimensional profile projections and best-fit spectra. Prospects remain for discovering strongly-interacting sparticles at the LHC, in both the scenarios with and without the (g-2)_μ constraint, as well as for discovering electroweakly-interacting sparticles at a future linear e

  15. Silver bullet or trojan horse? The effects of inclusionary zoning on local housing markets in the United States.

    PubMed

    Schuetz, Jenny; Meltzer, Rachel; Been, Vicki

    2011-01-01

    Many local governments are adopting inclusionary zoning (IZ) as a means of producing affordable housing without direct public subsidies. In this paper, panel data on IZ in the San Francisco metropolitan area and suburban Boston are used to analyse how much affordable housing the programmes produce and how IZ affects the prices and production of market-rate housing. The amount of affordable housing produced under IZ has been modest and depends primarily on how long IZ has been in place. Results from suburban Boston suggest that IZ has contributed to increased housing prices and lower rates of production during periods of regional house price appreciation. In the San Francisco area, IZ also appears to increase housing prices in times of regional price appreciation, but to decrease prices during cooler regional markets. There is no evidence of a statistically significant effect of IZ on new housing development in the Bay Area.

  16. Only two mutations detected in 15 Tunisian patients with 11β-hydroxylase deficiency: the p.Q356X and the novel p.G379V.

    PubMed

    Kharrat, M; Trabelsi, S; Chaabouni, M; Maazoul, F; Kraoua, L; Ben Jemaa, L; Gandoura, N; Barsaoui, S; Morel, Y; M'rad, R; Chaabouni, H

    2010-10-01

    Steroid 11β-hydroxylase deficiency is the second most common cause of congenital adrenal hyperplasia, resulting in virilization, glucocorticoid deficiency and hypertension. The 11β-hydroxylase enzyme is encoded by the CYP11B1 gene and mutations in this gene are responsible for this disease. The aim of this study was to characterize mutations in the CYP11B1 gene and to determine their frequencies in a cohort of Tunisian patients. The molecular genetic analysis was performed by direct nucleotide sequencing of the CYP11B1 gene in 15 unrelated Tunisian patients suffering from classical 11β-hydroxylase deficiency. Only two mutations were detected in homozygous state in the CYP11B1 gene of all patients, the p.Q356X in exon 6 (26.6%) and the novel p.G379V in exon 7 with large prevalence (73.3%). This is the first report of screening for mutations of CYP11B1 gene in the Tunisian population and even in the Arab population. © 2010 John Wiley & Sons A/S.

  17. Measurement of activation of helium gas by 238U beam irradiation at about 11 A MeV

    NASA Astrophysics Data System (ADS)

    Akashio, A.; Tanaka, K.; Imao, H.; Uwamino, Y.

    2017-09-01

    A new helium-gas stripper system has been applied at the 11 A MeV uranium beam of the Radioactive Isotope Beam Factory of the RIKEN accelerator facility. Although the gas stripper is important for the heavy-ion accelerator facility, the residual radiation that is generated is a serious problem for maintenance work. The residual dose was evaluated by using three-layered activation samples of aluminium and bismuth. The γ-rays from produced radionuclides with in-flight fission of the 238U beam and from the material of the chamber activated by neutrons were observed by using a Ge detector and compared with the values calculated by using the Monte-Carlo simulation code PHITS.

  18. Libby Dam and Lake Koocanusa Project, Montana Left Bank Slope.

    DTIC Science & Technology

    1984-04-01

    cut prior to a shower of minor rockfall which characterized the cut slope during morning thawing. He had fortunately overslept. With the loss of site...WZuO-OZ -Z Qzmn omwoo B-20 I z Z- U. I-i *i w w 20 * ~’ Iz In v CY w i li gi f+ + + *x-ZOO -ZJZU 0.&MOO B-21I r~*w u OD x le 0z _ _ _ - - - - - 4cj LIj...i -4i UI Z 00Z - uIwu) u r-w o C-46 ’Ii, ii 0 L U Gi 4 II’ U II :1 - J IIlill U I w ",h "I w1! - -I Nil I >.- 1 • l ( -- 9 -- % II ,r 11 at 0 - i i a

  19. Neurocognitive disorders: cluster 1 of the proposed meta-structure for DSM-V and ICD-11.

    PubMed

    Sachdev, P; Andrews, G; Hobbs, M J; Sunderland, M; Anderson, T M

    2009-12-01

    In an effort to group mental disorders on the basis of aetiology, five clusters have been proposed. In this paper, we consider the validity of the first cluster, neurocognitive disorders, within this proposal. These disorders are categorized as 'Dementia, Delirium, and Amnestic and Other Cognitive Disorders' in DSM-IV and 'Organic, including Symptomatic Mental Disorders' in ICD-10. We reviewed the literature in relation to 11 validating criteria proposed by a Study Group of the DSM-V Task Force as applied to the cluster of neurocognitive disorders. 'Neurocognitive' replaces the previous terms 'cognitive' and 'organic' used in DSM-IV and ICD-10 respectively as the descriptor for disorders in this cluster. Although cognitive/organic problems are present in other disorders, this cluster distinguishes itself by the demonstrable neural substrate abnormalities and the salience of cognitive symptoms and deficits. Shared biomarkers, co-morbidity and course offer less persuasive evidence for a valid cluster of neurocognitive disorders. The occurrence of these disorders subsequent to normal brain development sets this cluster apart from neurodevelopmental disorders. The aetiology of the disorders is varied, but the neurobiological underpinnings are better understood than for mental disorders in any other cluster. Neurocognitive disorders meet some of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster. Further developments in the aetiopathogenesis of these disorders will enhance the clinical utility of this cluster.

  20. Differential cross section of γ n → K + Σ - on bound neutrons with incident photons from 1.1 to 3.6 GeV

    DOE PAGES

    Pereira, S. Anefalos; Mirazita, M.; Rossi, P.; ...

    2010-05-01

    Differential cross sections of the reaction γd → K +Σ –(p) have been measured with the CLAS detector at Jefferson Lab using incident photons with energies between 1.1 and 3.6 GeV. This is the first complete set of strangeness photoproduction data on the neutron covering a broad angular range. At energies close to threshold and up to E γ ~ 1.8 GeV, the shape of the angular distribution is suggestive of the presence of s -channel production mechanisms. For E γ > 1.8 GeV, a clear forward peak appears and becomes more prominent as the photon energy increases, suggesting contributionsmore » from t-channel production mechanisms. Furthermore, these data can be used to constrain future analysis of this reaction.« less

  1. 77 FR 23113 - Modification of VOR Federal Airways V-135 and V-137; Southwest United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ...-0654; Airspace Docket No. 11-AWP-8] RIN 2120-AA66 Modification of VOR Federal Airways V-135 and V-137...: This action modifies VHF omnidirectional range (VOR) Federal airways V-135 and V-137 by extending the... published in the Federal Register a notice of proposed rulemaking (NPRM) to modify V-135 and V-137 in the...

  2. Exploratory study of fission product yield determination from photofission of Pu 239 at 11 MeV with monoenergetic photons

    DOE PAGES

    Bhike, Megha; Tornow, W.; Krishichayan, -; ...

    2017-02-14

    Here, measurements of fission product yields play an important role for the understanding of fundamental aspects of the fission process. Recently, neutron-induced fission product-yield data of  239Pu at energies below 4 MeV revealed an unexpected energy dependence of certain fission fragments. In order to investigate whether this observation is prerogative to neutron-induced fission, a program has been initiated to measure fission product yields in photoinduced fission. Here we report on the first ever photofission product yield measurement with monoenergetic photons produced by Compton back-scattering of FEL photons. The experiment was performed at the High-Intensity Gamma-ray Source at Triangle Universities Nuclear Laboratorymore » on  239Pu at E γ = 11 MeV. In this exploratory study the yield of eight fission products ranging from  91Sr to  143Ce has been obtained.« less

  3. Exploratory study of fission product yield determination from photofission of Pu 239 at 11 MeV with monoenergetic photons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bhike, Megha; Tornow, W.; Krishichayan, -

    Here, measurements of fission product yields play an important role for the understanding of fundamental aspects of the fission process. Recently, neutron-induced fission product-yield data of  239Pu at energies below 4 MeV revealed an unexpected energy dependence of certain fission fragments. In order to investigate whether this observation is prerogative to neutron-induced fission, a program has been initiated to measure fission product yields in photoinduced fission. Here we report on the first ever photofission product yield measurement with monoenergetic photons produced by Compton back-scattering of FEL photons. The experiment was performed at the High-Intensity Gamma-ray Source at Triangle Universities Nuclear Laboratorymore » on  239Pu at E γ = 11 MeV. In this exploratory study the yield of eight fission products ranging from  91Sr to  143Ce has been obtained.« less

  4. {ital L}=1 Excitation in the Halo Nucleus {sup 11}Li

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Korsheninnikov, A.; Fukuda, S.; Ito, S.

    Collisions of {sup 11}Li+p at 68AMeV have been studied by correlational measurements. An excited state of {sup 11}Li at E{sup {asterisk}}{approx_equal}1.3MeV was observed. The measured angular distributions show the dipole nature of the excitation of the 1.3-MeV peak. The structure of the excited states and the ground state of {sup 11}Li is discussed. {copyright} {ital 1997} {ital The American Physical Society}

  5. Pure Single-Crystalline Na1.1V3O7.9 Nanobelts as Superior Cathode Materials for Rechargeable Sodium-Ion Batteries.

    PubMed

    Yuan, Shuang; Liu, Yong-Bing; Xu, Dan; Ma, De-Long; Wang, Sai; Yang, Xiao-Hong; Cao, Zhan-Yi; Zhang, Xin-Bo

    2015-03-01

    Pure single-crystalline Na 1.1 V 3 O 7.9 nanobelts are successfully synthesized for the first time via a facile yet effective strategy. When used as cathode materials for Na-ion batteries, the novel nanobelts exhibit excellent electrochemical performance. Given the ease and effectiveness of the synthesis route as well as the very promising electrochemical performance, the results obtained may be extended to other next-generation cathode materials for Na-ion batteries.

  6. Apollo 11 Command Service Module

    NASA Technical Reports Server (NTRS)

    1969-01-01

    A close-up view of the Apollo 11 command service module ready to be mated with the spacecraft LEM adapter of the third stage. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

  7. 76 FR 68674 - Proposed Amendment of VOR Federal Airways V-320 and V-440; Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ...-1014; Airspace Docket No. 11-AAL-19] RIN 2120-AA66 Proposed Amendment of VOR Federal Airways V-320 and V-440; Alaska AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... in Alaska, V-320 and V-440, due to the relocation of the Anchorage VOR navigation aid. This action is...

  8. Absolute differential cross sections for electron impact excitation of the 10.8-11.5 eV energy-loss states of CO2

    NASA Astrophysics Data System (ADS)

    Green, M. A.; Teubner, P. J. O.; Campbell, L.; Brunger, M. J.; Hoshino, M.; Ishikawa, T.; Kitajima, M.; Tanaka, H.; Itikawa, Y.; Kimura, M.; Buenker, R. J.

    2002-02-01

    Absolute differential cross sections (DCSs) for electron impact excitation of electronic states of CO2 in the 10.8-11.5 eV energy-loss range are reported. These data were obtained at the incident electron energies 20,30,60,100 and 200 eV and over the scattered electron angular range 3.5°-90°. The accuracy of our experimental methods has been established independently by using several different normalization techniques at both Sophia and Flinders Universities. Generalized oscillator strengths were derived from our measured DCSs and then extrapolated to zero momentum transfer, in order to determine the optical oscillator strengths. These optical oscillator strengths, where possible, are compared with the results from previous measurements and calculations.

  9. Magnetic characteristics of M2FeV3O11 (M = Mg, Zn, Pb, Co, Ni) compounds

    NASA Astrophysics Data System (ADS)

    Groń, T.; Blonska-Tabero, A.; Filipek, E.; Stokłosa, Z.; Duda, H.; Sawicki, B.

    2018-02-01

    The unusual physical characteristics of the multicomponent oxide systems renewed the interest as the potential cathode materials in high-energy cells. Since the earlier magnetic characteristics were not entirely conclusive, we report the results of dc magnetic measurements including higher harmonics of ac magnetic susceptibility of the M2FeV3O11 (M = Mg, Zn, Pb, Co, Ni) compounds. Ferrimagnetic long-range and antiferromagnetic short-range interactions for all compounds under study at low temperatures as well as superparamagnetic-like behavior with the blocking temperature of 29 K and the freezing parameter of 0.013 were observed. These effects are discussed within the framework of superexchange and double exchange magnetic interactions as well as the mixed valence band of iron ions.

  10. Transverse momentum dependent two-pion Bose-Einstein correlations in Au + Au collisions at 11.6 A (center-dot) GeV/c

    NASA Technical Reports Server (NTRS)

    Lee, J. H.

    1998-01-01

    Bose-Einstein correlations of (pi)(sup +)(pi)(sup +) and (pi)(sup -) (pi)(sup -) pairs collected by the BNL-E866 Forward Spectrometer in 11.6 A(center-dot)GeV/c Au + Au collisions have been measured. The data were analyzed using three-dimensional correlation functions parameterized by the Yano-Koonin-Potgoretskii and Bertsch-Pratt formalism to study transverse momentum dependent source parameters. Rapid decreases of longitudinal source radii and slower decreases in the transverse parameters with increasing transverse momentum were observed, which suggests a strong longitudinal and some transverse expansion. A freeze-out time (tau)(sub 0) was derived as 4.5--5 fm/c, under the assumption of the freeze-out temperature T = 130 MeV, and the duration of emission was found to be (delta)(tau) (approx) 2--4 fm/c.

  11. Differences between motor point and innervation zone locations in the biceps brachii. An exploratory consideration for the treatment of spasticity with botulinum toxin.

    PubMed

    Guzmán-Venegas, Rodrigo A; Araneda, Oscar F; Silvestre, Rony A

    2014-12-01

    Botulinum toxin (BTX) acts on the neuromuscular junction which can be located by the innervation zone (IZ). Clinically, the motor point (MP) is homologous to the IZ and it is used as the injection site of BTX. Differences in the effectiveness of the application of BTX between MP and IZ locations have been determined. Compare the location of the MP obtained using electrical stimulation and the location of the IZ using a linear surface electrodes array on the biceps brachii muscle. The biceps brachii muscle of twenty men was assessed. The MP was located using the torque measurement generated by electrical stimulation. The IZ was detected using a linear surface electrodes array. A difference between the MP and the IZ positions (75.8 vs. 86.5mm, delta 10.7 mm; p=0.003, post-hoc power 0.89) was observed. The magnitude of the difference between the MP and the IZ may be clinically relevant. The IZ location using surface electromyography as a guide to optimize BTX injection is proposed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihydroxysaxitoxin.

    PubMed

    Mulcahy, John V; Walker, James R; Merit, Jeffrey E; Whitehead, Alan; Du Bois, J

    2016-05-11

    The paralytic shellfish poisons are a collection of guanidine-containing natural products that are biosynthesized by prokaryote and eukaryote marine organisms. These compounds bind and inhibit isoforms of the mammalian voltage-gated Na(+) ion channel at concentrations ranging from 10(-11) to 10(-5) M. Here, we describe the de novo synthesis of three paralytic shellfish poisons, gonyautoxin 2, gonyautoxin 3, and 11,11-dihydroxysaxitoxin. Key steps include a diastereoselective Pictet-Spengler reaction and an intramolecular amination of an N-guanidyl pyrrole by a sulfonyl guanidine. The IC50's of GTX 2, GTX 3, and 11,11-dhSTX have been measured against rat NaV1.4, and are found to be 22 nM, 15 nM, and 2.2 μM, respectively.

  13. Determination of the beam-spin asymmetry of deuteron photodisintegration in the energy region Eγ=1.1 -2.3 GeV

    NASA Astrophysics Data System (ADS)

    Zachariou, N.; Ilieva, Y.; Berman, B. L.; Ivanov, N. Ya.; Sargsian, M. M.; Avakian, R.; Feldman, G.; Nadel-Turonski, P.; Adhikari, K. P.; Adikaram, D.; Anderson, M. D.; Pereira, S. Anefalos; Avakian, H.; Badui, R. A.; Baltzell, N. A.; Battaglieri, M.; Baturin, V.; Bedlinskiy, I.; Biselli, A. S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Cao, T.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Compton, N.; Contalbrigo, M.; Cortes, O.; Crede, V.; D'Angelo, A.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Dupre, R.; Egiyan, H.; Alaoui, A. El; Fassi, L. El; Elouadrhiri, L.; Fedotov, G.; Fegan, S.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Fradi, A.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Glazier, D. I.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Hafidi, K.; Hanretty, C.; Harrison, N.; Hattawy, M.; Hicks, K.; Ho, D.; Holtrop, M.; Hughes, S. M.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jiang, H.; Jo, H. S.; Joo, K.; Keller, D.; Khachatryan, G.; Khandaker, M.; Kim, A.; Kim, W.; Klein, F. J.; Kubarovsky, V.; Lenisa, P.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Markov, N.; Mattione, P. T.; McKinnon, B.; Mineeva, T.; Mirazita, M.; Mokeeev, V. I.; Montgomery, R. A.; Moutarde, H.; Camacho, C. Munoz; Net, L. A.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Phelps, W.; Phillips, J. J.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Puckett, A. J. R.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Senderovich, I.; Sharabian, Y. G.; Skorodumina, Iu.; Smith, G. D.; Sober, D. I.; Sokhan, D.; Sparveris, N.; Stepanyan, S.; Strauch, S.; Sytnik, V.; Taiuti, M.; Tian, Ye; Ungaro, M.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D.; Wei, X.; Wood, M. H.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.; CLAS Collaboration

    2015-05-01

    The beam-spin asymmetry, Σ , for the reaction γ d →p n has been measured using the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Accelerator Facility (JLab) for six photon-energy bins, between 1.1 and 2.3 GeV, and proton angles in the center-of-mass frame, θc .m ., between 25∘ and 160∘. These are the first measurements of beam-spin asymmetries at θc .m .=90∘ for photon-beam energies above 1.6 GeV, and the first measurements for angles other than θc .m .=90∘ . The angular and energy dependence of Σ is expected to aid in the development of QCD-based models to understand the mechanisms of deuteron photodisintegration in the transition region between hadronic and partonic degrees of freedom, where both effective field theories and perturbative QCD cannot make reliable predictions.

  14. Effects of the innervation zone on the time and frequency domain parameters of the surface electromyographic signal.

    PubMed

    Smith, Cory M; Housh, Terry J; Herda, Trent J; Zuniga, Jorge M; Ryan, Eric D; Camic, Clayton L; Bergstrom, Haley C; Smith, Doug B; Weir, Joseph P; Cramer, Joel T; Hill, Ethan C; Cochrane, Kristen C; Jenkins, Nathaniel D M; Schmidt, Richard J; Johnson, Glen O

    2015-08-01

    The purposes of the present study were to examine the effects of electrode placements over, proximal, and distal to the innervation zone (IZ) on electromyographic (EMG) amplitude (RMS) and frequency (MPF) responses during: (1) a maximal voluntary isometric contraction (MVIC), and; (2) a sustained, submaximal isometric muscle action. A linear array was used to record EMG signals from the vastus lateralis over the IZ, 30mm proximal, and 30mm distal to the IZ during an MVIC and a sustained isometric muscle action of the leg extensors at 50% MVIC. During the MVIC, lower EMG RMS (p>0.05) and greater EMG MPF (p<0.05) values were recorded over the IZ compared to away from the IZ, however, no differences in slope coefficients for the EMG RMS and MPF versus time relationships over, proximal, and distal to the IZ occurred. Thus, the results of the present study indicated that during an MVIC, EMG RMS and MPF values recorded over the IZ are not comparable to those away from the IZ. However, the rates of fatigue-induced changes in EMG RMS and MPF during sustained, submaximal isometric muscle actions of the leg extensors were the same regardless of the electrode placement locations relative to the IZ. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Station Climatic Summaries, North America. Volume 2. Alaska, Canada and Greenland

    DTIC Science & Technology

    1993-02-01

    36 IZ50 NNE 13 5$ 9 J7 1 4 17 11 a a 13 4 ISO NNE 4 52 9 1 21 1 41 19. :5 :S 10 1, 𔃻:: Z. 1:9 1 4ý1 11 1 2 :07 165 E 7 67 V.c 1 9 1, . ý I IDECp 8 1...WP.T. SASKATOIEAN4 p11100 i8-t976 a $lueLye$ C429 ,"omber 197r ILOCA&130N 𔃾S 26 WIN7 40 9LX 184 1Im AN ISO US00 AW CLMATIC. BRE- --- L ItI of. o4 U1 99...JUN 62 45 33 14 4.1 3.1 57 W 7 55 8583 . 9003 1 014621 JUL 78 50 3725 3.0.0 _# #W 7 477972 35.21900 5 20 0 010153 5 0 6 AUG72 -318 5.3 4.9 1 4W 7 47875

  16. Prime Contractors with Awards Over $25,000 by Major System, Contractor and State. Part 2. AVJ Navy OV-10 Coin (Now Bronco) thru SMR Navy Swygert Shipyards, Inc.

    DTIC Science & Technology

    1991-01-01

    L. ..4L L.C11-- -4If’ I .d m a. ə -II 01-0 -. > Ln C. 00SI. . oIL W - 4 () I- I -.40." .- 4 - 4 a-4aa4WLa r 1W.4 Iu00T -4 -14 0-I VI - n- :a 4- - 0...01 &M10.00.0 = -.0-D- CD .I 0%. 0.CA (J U I 00 - s _ 4L W))0 to1) (nO U) OIL -MMUU)flml 0U)EU )- )Cto IA0 0 0) (/) I " ZOJ 00 0- 0 0 00 0 0 . 0 0 0 0...i Cl) 0. .j zo C) cc ~ 0 10C31 C) w w <- >. ix LaJOZ < V) 0 0 f 𔃺 C- I OiL 0 -1 (Xi 0 1. 1--1- - Lu 0.L m I I .iZ 0 L 0 (1 L 0 41 0 "- M~OO 0 01

  17. A taxonomic monograph of the leaf-litter inhabiting weevil genus Plumolepilius new genus (Coleoptera: Curculionidae: Molytinae: Conotrachelini) from Mexico, Guatemala, and El Salvador.

    PubMed

    Barrios-Izás, Manuel A; Anderson, Robert S; Morrone, Juan J

    2016-09-14

    We describe the Mesoamerican leaf litter weevil genus Plumolepilius Barrios-Izás & Anderson, new genus (Coleoptera: Curculionidae: Molytinae: Conotrachelini) (type species P. trifiniensis Barrios-Izás & Anderson, new species), species of which inhabit mountain ecosystems from the state of Chiapas in southeastern Mexico to northern Panama. In this paper we describe nine new species from Mexico, Guatemala, and El Salvador: P. trifiniensis Barrios-Izás & Anderson, new species (El Salvador and Guatemala); P. branstetteri Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. longinoi Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. cortezi Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. canoi Barrios-Izás & Anderson, new species (Guatemala); P. schusteri Barrios-Izás & Anderson, new species (Guatemala and Mexico); P. daryi Barrios-Izás & Anderson, new species (Guatemala); P. yolnabajensis Barrios-Izás & Anderson, new species (Guatemala); and P. macalajauensis Barrios-Izás & Anderson, new species (Guatemala).        The genus and the species are named and described, information on their geographical distributions is given and images of the habitus of both sexes and the aedeagus are presented. A key to the species of Plumolepilius based on males is included.        The monophyly of Plumolepilius was confirmed by a parsimony analysis of external and male aedeagus morphology and the genus is best characterized by the presence of plumose scales lining the prosternal channel. Phylogenetic analysis supports that Lepilius Champion 1905 is the sister genus of Plumolepilius.

  18. Development of a Flight Simulation Concept and Aerodynamic Buildup for Investigation of Departure Prevention Systems in Tactical Aircraft.

    DTIC Science & Technology

    1983-09-01

    I - c).Il.- 4 - OIL 1-0 40CA I ..04uLU 1-Z Z ម 00 >O~ 0 CC cc3 0 WCLW X04 g ’"-J0t-0QtcW at Z1--W0Uaow( W" 01- ZZ0Z :3 JCCQ~Aw1-cO 00’-ZI.-0’ Z4... OIL 40 ft.~~L ft t U- U~r ~- b O* - 0 . i 0LL ,;V; 0 O U. W l- oIZ 0U 0 Q W --. " Z-f Ci IL LU - 4 QILL0 - .% 0 (J wU--󈧭- 2 u Q - -JL ZU 0-’ 2 I - w Ow...0 0.440 -0t UI20-.Jc ’A 28.- >.J0Zb4 -JovV-$- UJa 8- C9444L W4-LU 4ao. a L . .4~ 11.0QQ 000002 .U.4’U. z 00".-Po .44in..4 0~4 LUV ., i

  19. Origin and Properties of Quiet-time 0.11–1.28 MeV Nucleon{sup −1} Heavy-ion Population Near 1 au

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dayeh, M. A.; Desai, M. I.; Ebert, R. W.

    Using measurements from the Advanced Composition Explorer /Ultra-Low Energy Isotope Spectrometer near 1 au, we surveyed the composition and spectra of heavy ions (He-through-Fe) during quiet times from 1998 January 1 to 2015 December 31 at suprathermal energies between ∼0.11 and ∼1.28 MeV nucleon{sup −1}. The selected time period covers the maxima of solar cycles 23 and 24 and the extended solar minimum in between. We find the following. (1) The number of quiet hours in each year correlates well with the sunspot number, year 2009 was the quietest for about 82% of the time. (2) The composition of themore » quiet-time suprathermal heavy-ion population ({sup 3}He, C-through-Fe) correlates well with the level of solar activity, exhibiting SEP-like composition signatures during solar maximum, and CIR- or solar wind-like composition during solar minimum. (3) The heavy-ion (C–Fe) spectra exhibit suprathermal tails at energies of 0.11–0.32 MeV nucleon{sup −1} with power-law spectral indices ranging from 1.40 to 2.97. Fe spectra soften (steepen, i.e., spectral index increases) smoothly with increasing energies compared with Fe, indicating a rollover behavior of Fe at higher energies (0.45–1.28 MeV nucleon{sup −1}). (4) Spectral indices of Fe and O do not appear to exhibit clear solar cycle dependence. (2) and (3) imply that during IP quiet times and at energies above ∼0.1 MeV nucleon{sup −1}, the IP medium is dominated by material from prior solar and interplanetary events. We discuss the implications of these extended observations in the context of the current understanding of the suprathermal ion population near 1 au.« less

  20. NuSTAR spectral analysis of two bright Seyfert 1 galaxies: MCG +8-11-11 and NGC 6814

    NASA Astrophysics Data System (ADS)

    Tortosa, A.; Bianchi, S.; Marinucci, A.; Matt, G.; Middei, R.; Piconcelli, E.; Brenneman, L. W.; Cappi, M.; Dadina, M.; De Rosa, A.; Petrucci, P. O.; Ursini, F.; Walton, D. J.

    2018-01-01

    We report on the NuSTAR observations of two bright Seyfert 1 galaxies, namely MCG +8-11-11 (100 ks) and NGC 6814 (150 ks). The main goal of these observations was to investigate the Comptonization mechanisms acting in the innermost regions of an active galactic nucleus (AGN) which are believed to be responsible for the UV/X-ray emission. The spectroscopic analysis of the NuSTAR spectra of these two sources revealed that although they had different properties overall (black hole masses, luminosity and Eddington ratios), they had very similar coronal properties. Both presented a power-law spectrum with a high-energy cut-off at ∼150-200 keV, a relativistically broadened Fe K α line and the associated disc reflection component, plus a narrow iron line likely emitted in Compton thin and distant matter. The intrinsic continuum was well described by Comptonization models that show for MCG +8-11-11 a temperature of the coronal plasma of kTe ∼ 60 keV and an extrapolated optical depth τ = 1.8; for NGC 6814, the coronal temperature was kTe ∼ 45 keV with an extrapolated optical depth of τ = 2.5. We compare and discuss these values to some most common Comptonization models that aim at explaining the energy production and stability of coronae in AGNs.

  1. Toroidal high-spin isomers in the nucleus 304120

    NASA Astrophysics Data System (ADS)

    Staszczak, A.; Wong, Cheuk-Yin; Kosior, A.

    2017-05-01

    Background: Strongly deformed oblate superheavy nuclei form an intriguing region where the toroidal nuclear structures may bifurcate from the oblate spheroidal shape. The bifurcation may be facilitated when the nucleus is endowed with a large angular moment about the symmetry axis with I =Iz . The toroidal high-K isomeric states at their local energy minima can be theoretically predicted using the cranked self-consistent Skyrme-Hartree-Fock method. Purpose: We use the cranked Skyrme-Hartree-Fock method to predict the properties of the toroidal high-spin isomers in the superheavy nucleus 120304184. Method: Our method consists of three steps: First, we use the deformation-constrained Skyrme-Hartree-Fock-Bogoliubov approach to search for the nuclear density distributions with toroidal shapes. Next, using these toroidal distributions as starting configurations, we apply an additional cranking constraint of a large angular momentum I =Iz about the symmetry z axis and search for the energy minima of the system as a function of the deformation. In the last step, if a local energy minimum with I =Iz is found, we perform at this point the cranked symmetry- and deformation-unconstrained Skyrme-Hartree-Fock calculations to locate a stable toroidal high-spin isomeric state in free convergence. Results: We have theoretically located two toroidal high-spin isomeric states of 120304184 with an angular momentum I =Iz=81 ℏ (proton 2p-2h, neutron 4p-4h excitation) and I =Iz=208 ℏ (proton 5p-5h, neutron 8p-8h) at the quadrupole moment deformations Q20=-297.7 b and Q20=-300.8 b with energies 79.2 and 101.6 MeV above the spherical ground state, respectively. The nuclear density distributions of the toroidal high-spin isomers 120304184(Iz=81 ℏ and 208 ℏ ) have the maximum density close to the nuclear matter density, 0.16 fm-3, and a torus major to minor radius aspect ratio R /d =3.25 . Conclusions: We demonstrate that aligned angular momenta of Iz=81 ℏ and 208 ℏ arising from

  2. 76 FR 79140 - Proposed Modification of VOR Federal Airways V-135 and V-137; Southwest United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ...-0654; Airspace Docket No. 11-AWP-8] RIN 2120-AA66 Proposed Modification of VOR Federal Airways V-135 and V-137; Southwest United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... omnidirectional range (VOR) Federal airways V-135 and V-137 by extending the airways to the Mexicali, Mexico VOR...

  3. Heteromerization and colocalization of TrpV1 and TrpV2 in mammalian cell lines and rat dorsal root ganglia.

    PubMed

    Rutter, A Richard; Ma, Qing-Ping; Leveridge, Mathew; Bonnert, Timothy P

    2005-11-07

    Coassociation of the vanilloid transient receptor potential (Trp) ion channels, TrpV1 and TrpV2, was investigated by immunoprecipitation and immunofluorescence in transfected mammalian cell lines, rat dorsal root ganglia and spinal cord. TrpV1/TrpV2 heteromeric complexes were coimmunoprecipitated from human embryonic kidney cells and F-11 dorsal root ganglion hybridoma cells following their transient coexpression. Immunofluorescent labelling of transfected F-11 cells revealed colocalization of TrpV1 and TrpV2 at the cell surface. Immunoprecipitation from rat dorsal root ganglion lysates identified a minor population of receptor complexes composed of TrpV1/TrpV2 heteromers, consistent with a small proportion of cells double-labelled with TrpV1 and TrpV2 antibodies in rat dorsal root ganglion sections. TrpV1/TrpV2 receptor complexes may represent a functionally distinct ion channel complex that may increase the diversity observed within the Trp ion channel family.

  4. Neurotensin analogs [D-TYR11] and [D-PHE11]neurotensin resist degradation by brain peptidases in vitro and in vivo.

    PubMed

    Checler, F; Vincent, J P; Kitabgi, P

    1983-12-01

    The present study was designed to compare the susceptibility of neurotensin (NT), [3H]NT, [D-Tyr11]NT and [D-Phe11]NT to degradation by 1) rat brain synaptic membranes in vitro and 2) after i.c.v. administration in the rat in vivo. Degradation was assessed by purifying the peptides using reverse phase high-performance liquid chromatography and by measuring the amount of radioactive or absorbing (OD 230) material under each peptide peak. In contrast to NT, [D-Tyr11]NT and [D-Phe11]NT were resistant to degradation by brain synaptic peptidases in vitro. Furthermore, NT was rapidly metabolized in brain tissues after i.c.v. administration, whereas [D-Tyr11]NT was metabolically stable. The present data confirm the central role of NT residue Tyr11 in the mechanisms of NT inactivation by brain synaptic peptidases. They account for the higher in vivo potency of [D-Tyr11]NT as compared with its in vitro potency. Finally, they explain, at least in part, the need to administer large doses of NT in the brain in order to observe neurobehavioral and neuropharmacological effects.

  5. Apollo 11 Moon Landing

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The crowning achievement for the Saturn V rocket came when it launched Apollo 11 astronauts, Neil Armstrong, Edwin (Buzz) Aldrin, and Michael Collins, to the Moon in July 1969. In this photograph, astronaut Aldrin takes his first step onto the surface of the Moon.

  6. Axisymmetric & non-axisymmetric exhaust jet induced-effects on a V/STOL vehicle design. Part 1: Data presentation. [conducted in Ames 11-foot transonic tunnel

    NASA Technical Reports Server (NTRS)

    Schnell, W. C.; Ordonez, G. W.

    1981-01-01

    A 1/8 scale jet-effects model was tested in the NASA Ames 11 ft transonic tunnel at static conditions and over a range of Mach numbers from 0.4 to 1.4. The data presented show that significant differences in aeropropulsion performance can be expected by varying the exhaust nozzle type and its geometric parameters on a V/STOL underwing nacelle installation.

  7. Experimental study of the p+{sup 6}Li{yields}{eta}+{sup 7}Be reaction 11.3 MeV above threshold

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Budzanowski, A.; Kliczewski, S.; Siudak, R.

    2010-10-15

    The cross section for the reaction p+{sup 6}Li{yields}{eta}+{sup 7}Be was measured at an excess energy of 11.28 MeV above threshold by detecting the recoiling {sup 7}Be nuclei. A dedicated set of focal plane detectors was built for the magnetic spectrograph Big Karl and was used for identification and four-momentum measurement of {sup 7}Be. A differential cross section of nb/(d{sigma}/d{Omega})=[0.69{+-}0.20(stat.){+-}0.20(syst.)] sr for the ground state plus 1/2{sup -} was measured. The result is compared to model calculations.

  8. Apollo 11 Launch HD SILENT

    NASA Image and Video Library

    2017-03-08

    On July 16, 1969, the huge, 363-feet tall Saturn V rocket launches on the Apollo 11 mission from Pad A, Launch Complex 39, Kennedy Space Center, at 9:32 a.m. EDT. Onboard the Apollo 11 spacecraft are astronauts Neil A. Armstrong, commander; Michael Collins, command module pilot; and Edwin E. Aldrin Jr., lunar module pilot. Apollo 11 was the United States' first lunar landing mission. While astronauts Armstrong and Aldrin descended in the Lunar Module "Eagle" to explore the Sea of Tranquility region of the moon, astronaut Collins remained with the Command and Service Modules "Columbia" in lunar orbit.

  9. Effect of the infrastructure material on the failure behavior of prosthetic crowns.

    PubMed

    Sonza, Queli Nunes; Della Bona, Alvaro; Borba, Márcia

    2014-05-01

    To evaluate the effect of infrastructure (IS) material on the fracture behavior of prosthetic crowns. Restorations were fabricated using a metal die simulating a prepared tooth. Four groups were evaluated: YZ-C, Y-TZP (In-Ceram YZ, Vita) IS produced by CAD-CAM; IZ-C, In-Ceram Zirconia (Vita) IS produced by CAD-CAM; IZ-S, In-Ceram Zirconia (Vita) IS produced by slip-cast; MC, metal IS (control). The IS were veneered with porcelain and resin cemented to fiber-reinforced composite dies. Specimens were loaded in compression to failure using a universal testing machine. The 30° angle load was applied by a spherical piston, in 37°C distilled water. Fractography was performed using stereomicroscope and SEM. Data were statistically analyzed with Anova and Student-Newman-Keuls tests (α=0.05). Significant differences were found between groups (p=0.022). MC showed the highest mean failure load, statistically similar to YZ-C. There was no statistical difference between YZ-C, IZ-C and IZ-S. MC and YZ-C showed no catastrophic failure. IZ-C and IZ-S showed chipping and catastrophic failures. The fracture behavior is similar to reported clinical failures. Considering the ceramic systems evaluated, YZ-C and MC crowns present greater fracture load and a more favorable failure mode than In-Ceram Zirconia crowns, regardless of the fabrication type (CAD-CAM or slip-cast). Copyright © 2014 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  10. V&V of MCNP 6.1.1 Beta Against Intermediate and High-Energy Experimental Data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mashnik, Stepan G

    This report presents a set of validation and verification (V&V) MCNP 6.1.1 beta results calculated in parallel, with MPI, obtained using its event generators at intermediate and high-energies compared against various experimental data. It also contains several examples of results using the models at energies below 150 MeV, down to 10 MeV, where data libraries are normally used. This report can be considered as the forth part of a set of MCNP6 Testing Primers, after its first, LA-UR-11-05129, and second, LA-UR-11-05627, and third, LA-UR-26944, publications, but is devoted to V&V with the latest, 1.1 beta version of MCNP6. The MCNP6more » test-problems discussed here are presented in the /VALIDATION_CEM/and/VALIDATION_LAQGSM/subdirectories in the MCNP6/Testing/directory. README files that contain short descriptions of every input file, the experiment, the quantity of interest that the experiment measures and its description in the MCNP6 output files, and the publication reference of that experiment are presented for every test problem. Templates for plotting the corresponding results with xmgrace as well as pdf files with figures representing the final results of our V&V efforts are presented. Several technical “bugs” in MCNP 6.1.1 beta were discovered during our current V&V of MCNP6 while running it in parallel with MPI using its event generators. These “bugs” are to be fixed in the following version of MCNP6. Our results show that MCNP 6.1.1 beta using its CEM03.03, LAQGSM03.03, Bertini, and INCL+ABLA, event generators describes, as a rule, reasonably well different intermediate- and high-energy measured data. This primer isn’t meant to be read from cover to cover. Readers may skip some sections and go directly to any test problem in which they are interested.« less

  11. Investigation of the role of 10Li resonances in the halo structure of 11Li through the 11Li (p , d)10Li transfer reaction

    NASA Astrophysics Data System (ADS)

    Sanetullaev, A.; Kanungo, R.; Tanaka, J.; Alcorta, M.; Andreoiu, C.; Bender, P.; Chen, A. A.; Christian, G.; Davids, B.; Fallis, J.; Fortin, J. P.; Galinski, N.; Gallant, A. T.; Garrett, P. E.; Hackman, G.; Hadinia, B.; Ishimoto, S.; Keefe, M.; Krücken, R.; Lighthall, J.; McNeice, E.; Miller, D.; Purcell, J.; Randhawa, J. S.; Roger, T.; Rojas, A.; Savajols, H.; Shotter, A.; Tanihata, I.; Thompson, I. J.; Unsworth, C.; Voss, P.; Wang, Z.

    2016-04-01

    The first measurement of the one-neutron transfer reaction 11Li(p,d)10Li performed using the IRIS facility at TRIUMF with a 5.7 A MeV11Li beam interacting with a solid H2 target is reported. The 10Li residue was populated strongly as a resonance peak with energy Er = 0.62 ± 0.04 MeV having a total width Γ = 0.33 ± 0.07 MeV. The angular distribution of this resonance is characterized by neutron occupying the 1p1/2 orbital. A DWBA analysis yields a spectroscopic factor of 0.67 ± 0.12 for p1/2 removal strength from the ground state of 11Li to the region of the peak.

  12. Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing

    PubMed Central

    Champagne, Devin P.; Shockett, Penny E.

    2014-01-01

    Illegitimate V(D)J recombination at oncogenes and tumor suppressor genes is implicated in formation of several T cell malignancies. Notch1 and Bcl11b, genes involved in developing T cell specification, selection, proliferation, and survival, were previously shown to contain hotspots for deletional illegitimate V(D)J recombination associated with radiation-induced thymic lymphoma. Interestingly, these deletions were also observed in wild-type animals. In this study, we conducted frequency, clonality, and junctional processing analyses of Notch1 and Bcl11b deletions during mouse development and compared results to published analyses of authentic V(D)J rearrangements at the T cell receptor beta (TCRβ) locus and illegitimate V(D)J deletions observed at the human, nonimmune HPRT1 locus not involved in T cell malignancies. We detect deletions in Notch1 and Bcl11b in thymic and splenic T cell populations, consistent with cells bearing deletions in the circulating lymphocyte pool. Deletions in thymus can occur in utero, increase in frequency between fetal and postnatal stages, are detected at all ages examined between fetal and 7 months, exhibit only limited clonality (contrasting with previous results in radiation-sensitive mouse strains), and consistent with previous reports are more frequent in Bcl11b, partially explained by relatively high Recombination Signal Information Content (RIC) scores. Deletion junctions in Bcl11b exhibit greater germline nucleotide loss, while in Notch1 palindromic (P) nucleotides are more abundant, although average P nucleotide length is similar for both genes and consistent with results at the TCRβ locus. Non-templated (N) nucleotide insertions appear to increase between fetal and postnatal stages for Notch1, consistent with normal terminal deoxynucleotidyl transferase (TdT) activity; however, neonatal Bcl11b junctions contain elevated levels of N insertions. Finally, contrasting with results at the HPRT1 locus, we find no obvious age or

  13. Molecular t-matrices for Low-Energy Electron Diffraction (TMOL v1.1)

    NASA Astrophysics Data System (ADS)

    Blanco-Rey, Maria; de Andres, Pedro; Held, Georg; King, David A.

    2004-08-01

    We describe a FORTRAN-90 program that computes scattering t-matrices for a molecule. These can be used in a Low-Energy Electron Diffraction program to solve the molecular structural problem very efficiently. The intramolecular multiple scattering is computed within a Dyson-like approach, using free space Green propagators in a basis of spherical waves. The advantage of this approach is related to exploiting the chemical identity of the molecule, and to the simplicity to translate and rotate these t-matrices without performing a new multiple-scattering calculation for each configuration. FORTRAN-90 routines for rotating the resulting t-matrices using Wigner matrices are also provided. Program summaryTitle of program: TMOL Catalogue number: ADUF Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADUF Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland. Computers: Alpha ev6-21264 (700 MHz) and Pentium-IV. Operating systems: Digital UNIX V5.0 and Linux (Red Hat 8.0). Programming language: FORTRAN-90/95 (Compaq True64 compiler, and Intel Fortran Compiler 7.0 for Linux). High-speed storage required for the test run: minimum 64 Mbytes, it can grow to more depending on the system considered. Disk storage required: None. No. of bits in a word: 64 and 32. No. of lines in distributed program, including test data etc.: 5404 No. of bytes in distributed program, including test data etc.: 59 856 Distribution format: tar.gz Nature of problem: We describe the FORTRAN-90 program TMOL (v1.1) for the computation of non-diagonal scattering t-matrices for molecules or any other poly-atomic sub-unit of surface structures. These matrices can be used in an standard Low-Energy Electron Diffraction program, such as LEED90 or CLEED. Method of solution: A general non-diagonal t-matrix is assumed for the atoms or more general scatterers forming the molecule. The molecular t-matrix is solved adding the possible intramolecular multiple scattering events

  14. Determination of the beam-spin asymmetry of deuteron photodisintegration in the energy region Eγ=1.1 –2.3 GeV

    DOE PAGES

    Zachariou, N.; Ilieva, Y.; Ivanov, N. Ya.; ...

    2015-05-01

    The beam-spin asymmetry, Σ, for the reaction γd→ΣΣpn has been measured using the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Accelerator Facility (JLab) for six photon-energy bins, between 1.1 and 2.3 GeV, and proton angles in the center-of-mass frame, Θ c.m., between 25° and 160°. These are the first measurements of beam-spin asymmetries at Θ c.m.=90° for photon-beam energies above 1.6 GeV, and the first measurements for angles other than Θ c.m.=90°. The angular and energy dependence of Σ is expected to aid in the development of QCD-based models to understand the mechanisms of deuteron photodisintegration inmore » the transition region between hadronic and partonic degrees of freedom, where both effective field theories and perturbative QCD cannot make reliable predictions.« less

  15. Bilateral Comparison of 1 V and 10 V Standards between the SMD (Belgium) and the BIPM October to December 2014 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Stock, M.; Vlad, D.

    2015-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the Service Métrologie—Metrologische Dienst (SMD), Brussel, Belgium, was carried out from October to November 2014. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM4 (Z4) and BIPM5 (Z5), were transported by freight to SMD and also back to BIPM. At SMD, the reference standard for DC voltage is a Josephson Voltage Standard (JVS). The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at SMD, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned toDC voltage standards by SMD, at the level of 1.018 V and 10 V, at SMD, USMD, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 5 November 2014. USMD - UBIPM = 0.14 mV; uc = 0.07 mV, at 1 V USMD - UBIPM = 0.09 mV; uc = 0.49 mV , at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at SMD, based on KJ-90, and the uncertainty related to the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  16. Bilateral Comparison of 1 V and 10 V Standards between the JV (Norway) and the BIPM, January to February 2015 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Stock, M.; Sengebush, F.

    2015-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the Justervesenet (JV), Kjeller, Norway, was carried out from January to February 2015. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM4 (Z4) and BIPM5 (Z5), were transported by freight to JV and also back to BIPM. At JV, the reference standard for DC voltage is a Josephson Voltage Standard. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at JV, withthe Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned toDC voltage standards by JV, at the level of 1.018 V and 10 V, at JV, UJV, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 28 January 2015. UJV - UBIPM = 0.23 μV uc = 0.03 μV , at 1 V UJV - UBIPM = 0.63 μV uc = 0.28 μV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at JV, based on KJ-90, and the uncertainty related to the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  17. Estimation of triterpenoids from Heliotropium marifolium Koen. ex Retz. in vivo and in vitro. I. Antimicrobial screening.

    PubMed

    Singh, B; Dubey, M M

    2001-05-01

    The hexane extract of Heliotropium marifolium yielded a mixture of triterpenoids: beta-sitosterol, stigmasterol, beta-amyrin, friedelan-3beta-ol (epifriedelenol), cycloartenone, beta-amyrin acetate, friedelin and epifriedenyl acetate. Isolated triterpenoid and reference antibiotics (gentamycin/mycostatin) were tested against selected pathogenic bacteria and fungi, e.g. Escherichia coli, Staphylococcus aureus, Aspergillus niger and Penicillium chrysogenum. The inhibition zone (IZ) and the activity index (AI) of isolated compounds were recorded and it was found that epifriedenyl acetate (IZ = 17; AI = 1.06) was the most active. The present study deals with the quantification and assessment of their growth inhibitory potency. It has been reported that cycloartenone was the major triterpenoid in both in vivo (0.54%) and in vitro (0.11%) cell cultures. Copyright 2001 John Wiley & Sons, Ltd.

  18. Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na{sub v}1.8 sodium channels expressed in Xenopus oocytes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Choi, J.-S.; Soderlund, David M.

    2006-03-15

    Pyrethroid insecticides bind to voltage-sensitive sodium channels and modify their gating kinetics, thereby disrupting nerve function. This paper describes the action of 11 structurally diverse commercial pyrethroid insecticides on the rat Na{sub v}1.8 sodium channel isoform, the principal carrier of the tetrodotoxin-resistant, pyrethroid-sensitive sodium current of sensory neurons, expressed in Xenopus laevis oocytes. All 11 compounds produced characteristic sodium tail currents following a depolarizing pulse that ranged from rapidly-decaying monoexponential currents (allethrin, cismethrin and permethrin) to persistent biexponential currents (cyfluthrin, cyhalothrin, cypermethrin and deltamethrin). Tail currents for the remaining compounds (bifenthrin, fenpropathrin, fenvalerate and tefluthrin) were monoexponential and decayed withmore » kinetics intermediate between these extremes. Reconstruction of currents carried solely by the pyrethroid-modified subpopulation of channels revealed two types of pyrethroid-modified currents. The first type, found with cismethrin, allethrin, permethrin and tefluthrin, activated relatively rapidly and inactivated partially during a 40-ms depolarization. The second type, found with cypermethrin, cyfluthrin, cyhalothrin, deltamethrin, fenpropathrin and fenvalerate, activated more slowly and did not detectably inactivate during a 40-ms depolarization. Only bifenthrin did not produce modified currents that fit clearly into either of these categories. In all cases, the rate of activation of modified channels was strongly correlated with the rate of tail current decay following repolarization. Modification of Na{sub v}1.8 sodium channels by cyfluthrin, cyhalothrin, cypermethrin and deltamethrin was enhanced 2.3- to 3.4-fold by repetitive stimulation; this effect appeared to result from the accumulation of persistently open channels rather than preferential binding to open channel states. Fenpropathrin was the most effective compound

  19. New Conceptual Model for Soil Treatment Units: Formation of Multiple Hydraulic Zones during Unsaturated Wastewater Infiltration.

    PubMed

    Geza, Mengistu; Lowe, Kathryn S; Huntzinger, Deborah N; McCray, John E

    2013-07-01

    Onsite wastewater treatment systems are commonly used in the United States to reclaim domestic wastewater. A distinct biomat forms at the infiltrative surface, causing resistance to flow and decreasing soil moisture below the biomat. To simulate these conditions, previous modeling studies have used a two-layer approach: a thin biomat layer (1-5 cm thick) and the native soil layer below the biomat. However, the effect of wastewater application extends below the biomat layer. We used numerical modeling supported by experimental data to justify a new conceptual model that includes an intermediate zone (IZ) below the biomat. The conceptual model was set up using Hydrus 2D and calibrated against soil moisture and water flux measurements. The estimated hydraulic conductivity value for the IZ was between biomat and the native soil. The IZ has important implications for wastewater treatment. When the IZ was not considered, a loading rate of 5 cm d resulted in an 8.5-cm ponding. With the IZ, the same loading rate resulted in a 9.5-cm ponding. Without the IZ, up to 3.1 cm d of wastewater could be applied without ponding; with the IZ, only up to 2.8 cm d could be applied without ponding. The IZ also plays a significant role in soil moisture distribution. Without the IZ, near-saturation conditions were observed only within the biomat, whereas near-saturation conditions extended below the biomat with the IZ. Accurate prediction of ponding is important to prevent surfacing of wastewater. The degree of water and air saturation influences pollutant treatment efficiency through residence time, volatility, and biochemical reactions. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  20. Connection from cortical area V2 to V3 A in macaque monkey.

    PubMed

    Anderson, John C; Martin, Kevan A C

    2005-08-01

    The V2 projection to V3 A was labeled by pressure microinjecting biotinylated dextran amine (BDA) and Phaseolus vulgaris lectin (PHA-L) into V2 just posterior to the lunate sulcus. Dense terminal labeling in clusters was found in layer 4, with a weaker terminal projection in layer 3. About 3.5--4.1% of the synapses in the densest bouton clusters in layer 4 were made by labeled boutons. All were asymmetric (Gray's type 1) synapses, made by spiny, excitatory neurons. The most frequently encountered synaptic targets were spines (76% in layer 4, 98% in layer 2/3). The remainder of the synaptic targets were dendritic shafts, of which just less than half (44%) had the characteristic ultrastructure of smooth (inhibitory) cells. Multisynaptic boutons were rare (mean synapses per bouton for layer 4 1.2, for layer 2/3 1.1). The mean size of the postsynaptic densities found on spines (0.11 microm(2)) was not significantly different from that for dendrites (0.09 microm(2)). In terms of their type, laminar location, number, and targets, the synapses that formed the V2 projection to V3 A are typical of a major, excitatory, feedforward projection of macaque visual cortex. (c) 2005 Wiley-Liss, Inc.

  1. Spatial characterization of innervation zones under electrically elicited M-wave.

    PubMed

    Zhang, C; Peng, Y; Li, S; Zhou, P; Munoz, A; Tang, D; Zhang, Y

    2016-08-01

    The three dimensional (3D) innervation zone (IZ) imaging approach (3DIZI) has been developed in our group to localize the IZ of a particular motor unit (MU) from its motor unit action potentials decomposed from high-density surface electromyography (EMG) recordings. In this study, the developed 3DIZI approach was combined with electrical stimulation to investigate global distributions of IZs in muscles from electrically elicited M-wave recordings. Electrical stimulations were applied to the musculocutaneous nerve to activate supramaximal muscle response of the biceps brachii in one healthy subject, and high-density (128 channels) surface EMG signals of the biceps brachii muscles were recorded. The 3DIZI approach was then employed to image the IZ distribution of IZs in the 3D space of the biceps brachii. The performance of the M-wave based 3DIZI approach was evaluated with different stimulation intensities. Results show that the reconstructed IZs under supramaximal stimulation are spatially distributed in the center region of muscle belly which is consistent with previous studies. With sub-maximal stimulation intensity, the imaged IZ centers became more proximally and deeply located. The proposed M-wave based 3DIZI approach demonstrated its capability of imaging global distribution of IZs in muscles, which provide valuable information for clinical applications such as guiding botulinum toxin injection in treating muscle spasticity.

  2. Investigation of the role of 10Li resonances in the halo structure of 11Li through the 11Li(p,d)10Li transfer reaction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sanetullaev, A.; Kanungo, R.; Tanaka, J.

    2016-03-02

    Here, the first measurement of the one-neutron transfer reaction 11Li(p,d) 10Li performed using the IRIS facility at TRIUMF with a 5.7A MeV 11Li beam interacting with a solid H 2 target is reported. The 10Li residue was populated strongly as a resonance peak with energy E r = 0.62 ± 0.04 MeV having a total width Γ = 0.33 ± 0.07 MeV. The angular distribution of this resonance is characterized by neutron occupying the 1p 1/2 orbital. A DWBA analysis yields a spectroscopic factor of 0.67 ± 0.12 for p 1/2 removal strength from the ground state of 11Li tomore » the region of the peak.« less

  3. Hyperfine-resolved 3.4-{mu}m spectroscopy of CH{sub 3}I with a widely tunable difference frequency generation source and a cavity-enhanced cell: A case study of a local Coriolis interaction between the v{sub 1}=1 and (v{sub 2},v{sub 6}{sup l})=(1,2{sup 2}) states

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Okubo, Sho; Nakayama, Hirotaka; Sasada, Hiroyuki

    Saturated absorption spectra of the {nu}{sub 1} fundamental band of CH{sub 3}I are recorded with a cavity-enhanced cell and a tunable difference frequency generation source having an 86-cm{sup -1} range. The recorded spectral lines are 250 kHz wide, and most of them are resolved into the individual hyperfine components. The Coriolis interaction between the v{sub 1}=1 and (v{sub 2},v{sub 6}{sup l})=(1,2{sup 2}) states locally perturbing the hyperfine structures is analyzed to yield the Coriolis and hyperfine coupling constants with uncertainties similar to those in typical microwave spectroscopy. The spectrometer has demonstrated the potential for precisely determining the energy structure inmore » the vibrational excited states.« less

  4. Recent advances in the study of 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2)Inhibitors.

    PubMed

    Zhou, Chunchun; Ye, Fan; Wu, He; Ye, Hui; Chen, Quanxu

    2017-06-01

    11β-Hydroxysteroid dehydrogenase (11β-HSD), which interconverts hormonally active cortisol and inactive cortisone in multiple human tissues, has two distinct isoforms named 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). 11β-HSD2 is an NAD + -dependent oxidase which lowers cortisol by converting it to cortisone while 11β-HSD1 mainly catalyzes the reduction which converts cortisone into cortisol. Selective inhibition of 11β-HSD2 is generally detrimental to health because the accumulation of cortisol can cause metabolic symptoms such as apparent mineralocorticoid excess (AME), fetal developmental defects and lower testosterone levels in males. There has been some advances on the study of 11β-HSD2 inhibitors and we think it necessary to make a summary of the characteristics and inhibiting properties of latest 11β-HSD2 inhibitors. As another review on 11β-HSD2 inhibitors has been issued on 2011 (see review (Ma et al., 2011)), this mini-review concerns advances during the last 5 years. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Development of High Level Electrical Stress Failure Threshold and Prediction Model for Small Scale Junction Integrated Circuits

    DTIC Science & Technology

    1978-09-01

    AWACS EMP Guidelines presents two different models to predict the damage pcwer of the dev-ce and the circuit damage EMP voltage ( VEMP ). Neither of...calculated as K P~ I V BD 6. The damage EMP voltage ( VEMP ) is calculated KZ EMP +IZ =D +BD VBD1F 7. The damage EMP voltage is calculated for collector

  6. Bilateral Comparison of 1 V and 10 V Standards between the NIS (Egypt) and the BIPM, August to September 2014 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Stock, M.; Abdel Mageed, Hala M.; Aladdin, Omar M.; Raouf, M. Helmy A.

    2015-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the National Institute for Standards (NIS), Giza, Egypt, was carried out from August to September 2014. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPMB (ZB) and BIPMC (ZC), were transported as hand luggage on board an airplane to NIS and back to BIPM. At NIS, the reference standard for DC voltage is a Josephson Voltage Standard. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at NIS, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned to DC voltage standards by NIS, at the level of 1.018 V and 10 V, at NIS, UNIS, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of the 7 September 2014. UNIS - UBIPM = 0.09 µV uc = 0.08 µV, at 1 V UNIS - UBIPM = 0.22 µV uc = 0.14 µV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NIS, based on KJ-90, and the uncertainty related to the comparison. This is a satisfactory result. The comparison result shows that the voltage standards maintained by NIS and the BIPM were equivalent, within their stated standard uncertainties, on the mean date of the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM

  7. Bilateral comparison of 1 V and 10 V standards between the INM (Romania) and the BIPM, August to October 2013 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Stock, M.; Simionescu, M.; Cîrneanu, L.

    2014-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the Institut National de Metrologie (INM), Bucharest, Romania, was carried out from August to October 2013. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM_7 (Z7) and BIPM_8 (Z8), were transported by freight to INM. At INM, the reference standard for DC voltage is a Josephson Voltage Standard. The output EMF (electromotive force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at INM, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned to DC voltage standards by INM, at the level of 1.018 V and 10 V, at INM, UINM, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 6 September 2013. UINM - UBIPM = -0.014 µV uc = 0.051 µV, at 1 V UINM - UBIPM = -0.43 µV uc = 0.34 µV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at INM, based on KJ-90, and the uncertainty related to the comparison. These are satisfactory results. The comparison results show that the voltage standards maintained by INM and the BIPM were equivalent, within the comparison uncertainty, on the mean date of the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual

  8. Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.

    PubMed

    Osteen, Jeremiah D; Sampson, Kevin; Iyer, Vivek; Julius, David; Bosmans, Frank

    2017-06-27

    The Na v 1.1 voltage-gated sodium channel is a critical contributor to excitability in the brain, where pathological loss of function leads to such disorders as epilepsy, Alzheimer's disease, and autism. This voltage-gated sodium (Na v ) channel subtype also plays an important role in mechanical pain signaling by primary afferent somatosensory neurons. Therefore, pharmacologic modulation of Na v 1.1 represents a potential strategy for treating excitability disorders of the brain and periphery. Inactivation is a complex aspect of Na v channel gating and consists of fast and slow components, each of which may involve a contribution from one or more voltage-sensing domains. Here, we exploit the Hm1a spider toxin, a Na v 1.1-selective modulator, to better understand the relationship between these temporally distinct modes of inactivation and ask whether they can be distinguished pharmacologically. We show that Hm1a inhibits the gating movement of the domain IV voltage sensor (VSDIV), hindering both fast and slow inactivation and leading to an increase in Na v 1.1 availability during high-frequency stimulation. In contrast, ICA-121431, a small-molecule Na v 1.1 inhibitor, accelerates a subsequent VSDIV gating transition to accelerate entry into the slow inactivated state, resulting in use-dependent block. Further evidence for functional coupling between fast and slow inactivation is provided by a Na v 1.1 mutant in which fast inactivation removal has complex effects on slow inactivation. Taken together, our data substantiate the key role of VSDIV in Na v channel fast and slow inactivation and demonstrate that these gating processes are sequential and coupled through VSDIV. These findings provide insight into a pharmacophore on VSDIV through which modulation of inactivation gating can inhibit or facilitate Na v 1.1 function.

  9. CERT Resilience Management Model (RMM) v1.1: Code of Practice Crosswalk Commercial Version 1.1

    DTIC Science & Technology

    2011-10-01

    ISO /IEC 24762:2008 (E) 6 2.8 ISO /IEC 27002 :2005 (E) 6 2.9 ISO /IEC 27005:2008 (E) 6 2.10 ISO /IEC 31000:2009 (E) 6 2.11...webstore.ansi.org/. 2.8 ISO /IEC 27002 :2005 (E) ISO /IEC 27002 , “Code of practice for information security management” [ ISO /IEC 2005b], broaches the full...scope of security management, at points touching upon both IT management and disaster recovery. ISO /IEC 27002 is part of a growing “27000

  10. History of DCAS 1961. Volume V. Origins of the USAF Space Program 1945-1956

    DTIC Science & Technology

    1961-01-01

    AVAILABILITY CODES N! _______________ PHOTOGRAPH TIS SHEET AND RETURN TO DTIC-DDA-2 FORM DOCUMENT PROCESSING SHEE~~DTIC OC 970A OCT 79 AFSC HISTORICAL I...IZ ION OR HIGHER A THO ITY IN T E DI ECT LI COMMAN SIi Prepredundr te poviion ofAirFore Rgultio 21-1 nd ir ori i Sytem ComandSuplemnt N. Itheetoas...information as it appears in the narrative. It is to be hoped that additional information bearing on the formative years of the space program will appear as a

  11. IDC System Specification Document Version 1.1.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harris, James M.; Lober, Randall R.

    2015-02-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris V1.1 2/2015 IDC Reengineering Project Team Iteration I2 Review Comments M. Harris

  12. Solar Gamma Rays Above 8 MeV

    NASA Technical Reports Server (NTRS)

    Crannell, C. J.; Crannell, H.; Ramaty, R.

    1978-01-01

    Processes which lead to the production of gamma rays with energy greater than 8 MeV in solar flares are reviewed and evaluated. Excited states produced by inelastic scattering, charge exchange, and spallation reactions in the abundant nuclear species are considered in order to identify nuclear lines which may contribute to the Gamma ray spectrum of solar flares. The flux of 15.11 MeV Gamma rays relative to the flux of 4.44 MeV Gamma rays from the de-excitation of the corresponding states in C12 is calculated for a number of assumed distributions of exciting particles. This flux ratio is a sensitive diagnostic of accelerated particle spectra. Other high energy nuclear levels are not so isolated as the 15.11 MeV state and are not expected to be so strong. The spectrum of Gamma rays from the decay of Pi dey is sensitive to the energy distribution of particles accelerated to energies greater than 100 MeV.

  13. U.S. EPA, Pesticide Product Label, ALKEN FUNGUS TREATMENT V-2, 11/06/1967

    EPA Pesticide Factsheets

    2011-04-21

    , A r , / " ' " I .. 1 r ",- r \\ I J ~_ r I I " ,. , , III fJ[ , \\. I . \\ ' / . I , , ) [ ( I. I I / I I' I \\ • ,. I ') •• • 11/.,'1 ••. 11'./' ' I , , ) I ' / / " I \\ i / ( '\\ r" , r'l I ...

  14. Research on Advanced Nondestructive Evaluation (NDE) Methods for Aerospace Structures

    DTIC Science & Technology

    2004-03-01

    al iz ed re sp on se (l in ea r s ca le ) N or m al iz ed re sp on se (l in ea...variations showed some differences after weathering (Figure 4.2.2-2). 0.0 1.0 2.0 0 1 2 3 4 5 Weathering time (hours) N or m al iz ed p ea k ar ea 0.0...1.0 2.0 0 1 2 3 4 5 Weathering time (hours)N or m al iz ed p ea k he ig ht s (A) (B) 52 Prior to weathering, the height variation

  15. Bilateral comparison of 1 V and 10 V standards between the DEFNAT (Tunisia) and the BIPM February to March 2016 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Ben Salah, B.; Mallat, A.; Abene, L.; Stock, M.

    2016-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the Laboratoire de Métrologie Electrique, DEFNAT (Tunisia), was carried out from February to March 2016. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPMC (ZC) and BIPM6 (Z6), were transported by freight to DEFNAT and back to BIPM. In order to keep the Zeners powered during their transportation phase, a BIPM in-house voltage stabiliser was connected in parallel to the internal battery. The voltage stabiliser consists of a set of two batteries, electrically protected from surcharge-discharge, easy to recharge and is designed to power two transfer standards for 10 consecutive days. At DEFNAT, the reference standard for DC voltage is a Josephson Voltage Standard. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at DEFNAT, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned to DC voltage standards by DEFNAT, at the level of 1.018 V and 10 V, at DEFNAT, UDEFNAT, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of the 26th of February 2016. UDEFNAT - UBIPM = + 0.07 μV uc = 0.04 μV, at 1.018 V UDEFNAT - UBIPM = + 0.38 μV uc = 0.10 μV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NSAI-NML, based on KJ-90, and the uncertainty related to the comparison. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which

  16. Characterization of 1:1 Random Copolymers Obtained from 6-, 7-, 11-, and 12-Carbon Amino Acids.

    DTIC Science & Technology

    1993-10-22

    Random Copolymers Obtained From 6-, 7-, 11-, and 12-Carbon Amino Acids by C. G. Johnson and L. J. Mathias 0 T .... Prepared for Publication r. t in the...NOOOG4-f-j- From 6-, 7-, 11-, and 12-Carbon Amino Acids 1225 ~~~ :: V Co~de 413m(iUK C. G Johnson, and Lo J. Mathias ś RFORMING ORGANIZA7,iCN ;fAMjjS...distribution is unlimited. Copolymers were prepared from the title amino acids by rr ilt condensation under dry nitrogen. The resulting copolymers were

  17. Exploratory study of fission product yield determination from photofission of 239Pu at 11 MeV with monoenergetic photons

    NASA Astrophysics Data System (ADS)

    Bhike, Megha; Tornow, W.; Krishichayan, Tonchev, A. P.

    2017-02-01

    Measurements of fission product yields play an important role for the understanding of fundamental aspects of the fission process. Recently, neutron-induced fission product-yield data of 239Pu at energies below 4 MeV revealed an unexpected energy dependence of certain fission fragments. In order to investigate whether this observation is prerogative to neutron-induced fission, a program has been initiated to measure fission product yields in photoinduced fission. Here we report on the first ever photofission product yield measurement with monoenergetic photons produced by Compton back-scattering of FEL photons. The experiment was performed at the High-Intensity Gamma-ray Source at Triangle Universities Nuclear Laboratory on 239Pu at Eγ=11 MeV. In this exploratory study the yield of eight fission products ranging from 91Sr to 143Ce has been obtained.

  18. Neurodevelopmental disorders: cluster 2 of the proposed meta-structure for DSM-V and ICD-11.

    PubMed

    Andrews, G; Pine, D S; Hobbs, M J; Anderson, T M; Sunderland, M

    2009-12-01

    DSM-IV and ICD-10 are atheoretical and largely descriptive. Although this achieves good reliability, the validity of diagnoses can be increased by an understanding of risk factors and other clinical features. In an effort to group mental disorders on this basis, five clusters have been proposed. We now consider the second cluster, namely neurodevelopmental disorders. We reviewed the literature in relation to 11 validating criteria proposed by a DSM-V Task Force Study Group. This cluster reflects disorders of neurodevelopment rather than a 'childhood' disorders cluster. It comprises disorders subcategorized in DSM-IV and ICD-10 as Mental Retardation; Learning, Motor, and Communication Disorders; and Pervasive Developmental Disorders. Although these disorders seem to be heterogeneous, they share similarities on some risk and clinical factors. There is evidence of a neurodevelopmental genetic phenotype, the disorders have an early emerging and continuing course, and all have salient cognitive symptoms. Within-cluster co-morbidity also supports grouping these disorders together. Other childhood disorders currently listed in DSM-IV share similarities with the Externalizing and Emotional clusters. These include Conduct Disorder, Attention Deficit Hyperactivity Disorder and Separation Anxiety Disorder. The Tic, Eating/Feeding and Elimination disorders, and Selective Mutisms were allocated to the 'Not Yet Assigned' group. Neurodevelopmental disorders meet some of the salient criteria proposed by the American Psychiatric Association (APA) to suggest a classification cluster.

  19. MISR-Versioning-V23

    Atmospheric Science Data Center

    2018-02-21

    ... MISR-Versioning-V23   Version Number: F13_0023 (aerosol), F08_0023 (land) Production Start Date: 11/1/2017 Product Updates:   This is a major revision to aerosol and land surface products, including both product format and algorithm ...

  20. Bilateral comparison of 1 V and 10 V standards between the DMDM (Serbia) and the BIPM, January to March 2014 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Stock, M.; Pantelic-Babic, J.; Sofranac, Z.; Zivkovic, V.

    2015-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the Directorate of Measures and Precious Metals (DMDM), Beograd, Serbia, was carried out from January to March 2014. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM6 (Z6) and BIPMA (ZA), were transported by freight to DMDM. At DMDM, the reference standard for DC voltage is a Josephson Voltage Standard. The output electromotive force of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at DMDM, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned to DC voltage standards by DMDM, at the level of 1.018 V and 10 V, at DMDM, UDMDM, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of the 13 February 2014. UDMDM - UBIPM = 0.094 µV uc = 0.072 µV, at 1 V UDMDM - UBIPM = 0.39 µV uc = 0.12 µV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at DMDM, based on KJ-90, and the uncertainty related to the comparison. The results at the 10 V level are not covered by the uncertainties with a coverage factor of 2. After the distribution of the Draft A, the DMDM discovered that the pressure gauge was defective. Some considerations on the correction to apply on the comparison result and the corresponding uncertainties are presented in the report. Nevertheless, the above results fully cover the CMCs of DMDM which are significantly larger. No corrections for temperature and pressure are applied in calibrations for

  1. Bilateral comparison of 1 V and 10 V standards between the NMISA (South Africa) and the BIPM April to June 2017 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Matlejoane, A. M.; Magagula, L.; Stock, M.

    2018-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1.018 V and 10 V voltage reference standards of the BIPM and the National Metrology Institute of South Africa, NMISA (South Africa), was carried out from April to June 2017. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPMA (ZA) and BIPMB (ZB), were transported by freight to NMISA and back to BIPM. In order to keep the Zeners powered during their transportation phase, a voltage stabilizer developed by BIPM was connected in parallel to the internal battery. It consists of a set of two batteries, electrically protected from surcharge-discharge, easy to recharge and is designed to power two transfer standards for ten consecutive days. At NMISA, the reference standard for DC voltage is a Josephson Voltage Standard. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at NMISA, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned to DC voltage standards by NMISA, at the level of 1.018 V and 10 V, at NMISA, UNMISA, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference dates of the 19th and 18th of May 2017, respectively. UNMISA - UBIPM = + 0.07 μV uc = 0.02 μV, at 1.018 V UNMISA - UBIPM = + 0.001 μV uc = 0.34 μV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NMISA, based on KJ-90, and the uncertainty related to the comparison. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which

  2. Electronic Principles Inventory, Keesler Technical Training Center.

    DTIC Science & Technology

    1984-04-01

    DEVICES S1188 56 PHOTO SENSITIVE DEVICES S1202 57 SYNCHRONOUS VIBRATIONS (CHOPPER LIRCUITS) $1207 58 INFRARED SYSTEMS T1216 59 LASERS T1244 60 DISPLAY...00 0 Iz 0 0 0 .. JZ 0- 4 a. LI 0 j a: o W c 0 ) 61w 3,v"kn V Ina.O..II 0 o I ww2 . ~ L 0 I Q9 CL. Q. C KV)W-94- K 4 JL U , -j 0-C wo w i6 It 5 - - P

  3. X-ray observations of the supernova remnant MSH 11-54

    NASA Technical Reports Server (NTRS)

    Agrawal, P. C.; Riegler, G. R.

    1980-01-01

    Soft X-ray observations of the X-ray source H1122-59 in the 0.4-2 keV band made with the low-energy detector 1 of the HEAO A-2 experiment are described. Based on positional coincidence, the source is identified with the supernova remnant MSH-11-54, thus confirming the report of Share et al. (1980). The object is a bright source in the 0.4-2 keV band with an X-ray flux of 9 x 10 to the -11th ergs/sq cm s near the earth. The measured source spectrum implies a plasma temperature of 4 million K and X-ray luminosity in the 0.4-2 keV band of 10 to the 37th ergs/s using a distance of 10 kpc for MSH 11-54. The X-ray observations, interpreted in terms of an adiabatic shock wave model, give a shock velocity of about 560 km/s and a supernova age of about 2300 yr, in good agreement with the age derived from the radio observations.

  4. Measurement of elliptic flow of light nuclei at s N N = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV at the BNL Relativistic Heavy Ion Collider

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adamczyk, L.; Adkins, J. K.; Agakishiev, G.

    Here we present measurements of second-order azimuthal anisotropy ( v 2 ) at midrapidity ( |y| < 1.0 ) for light nuclei d , t , 3He (formore » $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV) and antinuclei$$\\bar{d}$$ ( $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, and 19.6 GeV) and 3 ¯¯¯¯¯ He ( $$\\sqrt{s}$$$_{NN}$$ = 200 GeV) in the STAR (Solenoidal Tracker at RHIC) experiment. The v 2 for these light nuclei produced in heavy-ion collisions is compared with those for p and $$\\bar{p}$$. We observe mass ordering in nuclei v 2 ( p T) at low transverse momenta ( p T < 2.0 GeV/c). We also find a centrality dependence of v 2 for d and $$\\bar{d}$$ . The magnitude of v 2 for t and 3He agree within statistical errors. Light-nuclei v 2 are compared with predictions from a blast-wave model. Atomic mass number ( A ) scaling of light-nuclei v 2 (p T) seems to hold for p T / A < 1.5 GeV/c . Results on light-nuclei v 2 from a transport-plus-coalescence model are consistent with the experimental measurements.« less

  5. Measurement of elliptic flow of light nuclei at s N N = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV at the BNL Relativistic Heavy Ion Collider

    DOE PAGES

    Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; ...

    2016-09-23

    Here we present measurements of second-order azimuthal anisotropy ( v 2 ) at midrapidity ( |y| < 1.0 ) for light nuclei d , t , 3He (formore » $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV) and antinuclei$$\\bar{d}$$ ( $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, and 19.6 GeV) and 3 ¯¯¯¯¯ He ( $$\\sqrt{s}$$$_{NN}$$ = 200 GeV) in the STAR (Solenoidal Tracker at RHIC) experiment. The v 2 for these light nuclei produced in heavy-ion collisions is compared with those for p and $$\\bar{p}$$. We observe mass ordering in nuclei v 2 ( p T) at low transverse momenta ( p T < 2.0 GeV/c). We also find a centrality dependence of v 2 for d and $$\\bar{d}$$ . The magnitude of v 2 for t and 3He agree within statistical errors. Light-nuclei v 2 are compared with predictions from a blast-wave model. Atomic mass number ( A ) scaling of light-nuclei v 2 (p T) seems to hold for p T / A < 1.5 GeV/c . Results on light-nuclei v 2 from a transport-plus-coalescence model are consistent with the experimental measurements.« less

  6. Determination of total vanadium and vanadium(V) in groundwater from Mt. Etna and estimate of daily intake of vanadium(V) through drinking water.

    PubMed

    Arena, Giovanni; Copat, Chiara; Dimartino, Angela; Grasso, Alfina; Fallico, Roberto; Sciacca, Salvatore; Fiore, Maria; Ferrante, Margherita

    2015-06-01

    Vanadium(V) can be found in natural waters in the form of V(IV) and V(V) species, which have different biological properties and toxicity. The purpose of this study was to determine the concentrations of total V and V(V) in groundwater from the area of Mt. Etna and to assess the estimated daily intake (EDI) of V(V) of adults and children through drinking water. Water was sampled monthly at 21 sites in 2011. Total vanadium was determined by inductively coupled plasma-mass spectrometry (ICP-MS) and speciation by ion chromatography-ICP-MS (IC-ICP-MS). The concentration of V(V) species ranged from 62.8 to 98.9% of total V, with significantly higher concentrations in samples from the S/SW slope of Mt. Etna. The annual mean concentrations of total V exceeded the Italian legal limit of 140 μg/L at four sites on the S/SW slope. In the absence of thresholds for V(V) intake, only the Environmental Protection Agency (EPA) has calculated a reference dose. Children's EDI of V(V) at the sites with the higher V concentrations exceeded EPA thresholds (9 μg/kg/day). In particular, we found in Camporotondo, Mascalucia, Ragalna and San Pietro Clarenza sites children's EDIs of 11, 9.3, 11 and 9.9, respectively. The EDI of V(V) was significantly higher than the literature range (0.09-0.34 μg/kg/day).

  7. Mass attenuation coefficients in the range 3.8⩽E⩽11 keV, K fluorescence yield and Kβ/Kα relative X-ray emission rate for Ti, V, Fe, Co, Ni, Cu and Zn measured with a tunable monochromatic X-ray source

    NASA Astrophysics Data System (ADS)

    Ménesguen, Y.; Lépy, M.-C.

    2010-08-01

    This work presents new measurements of mass attenuation coefficients in the range 3.8⩽E⩽11 keV, K-absorption jump-ratios, Kα and Kβ fluorescence yields for Ti, V, Fe, Co, Ni, Cu and Zn. We use the experimental facility SOLEX, a tunable monochromatic X-ray source combined with an energy-dispersive high-purity germanium detector. The results are compared with theoretical values as well as with other experimental data and show a relatively good agreement. However, the derived K-jump-ratios appear larger than those widely used in the XCOM database. The Kα and Kβ fluorescence yields and the corresponding relative emission rates Kβ/Kα are also derived, which was made possible by the use of energy-dispersive detectors with good spectral resolution.

  8. Refinement and Verification of Predictive Models of Suspended Sediment Dispersion and Desorption of Toxics from Dredged Sediments.

    DTIC Science & Technology

    1982-07-01

    C ~ DO 680 J=1,NSTEP FOREX =SQRT(ADELX(J+1) *4.* (EZ* ( +EXPCO*EXP( - ’ADELX(J+1)/100.)))) DO 680 IZ=1,21 AZ=(IZ-1) *DELZ TOP=(AZ+XL )/ FOREX - 166 ET...ERF(TOP) BOT= (AZ-XL )/ FOREX EB=ERF (BOT) Z( IZ,J+1)=0. 5*(ET-EB) 680 CONTINUE C C START FINITE DIFFERENCE SOLUTION IF(ISCE.EQ.3)GO TO 25 DO 100 I=IUP

  9. 2.7 MeV Ar11+ ion irradiation induced structural evolution in Lu2(Ti2-xLux)O7-x/2 pyrochlores

    NASA Astrophysics Data System (ADS)

    Yang, D. Y.; Liu, C. G.; Zhang, K. Q.; Xia, Y.; Chen, L. J.; Liu, H.; Li, Y. H.

    2015-11-01

    This paper aims to study the radiation effects of nonstoichiometric pyrochlore series Lu2(Ti2-xLux)O7-x/2 (x = 0-0.667). Polycrystalline Lu2(Ti2-xLux)O7-x/2 samples were irradiated with 2.7 MeV Ar11+ ions up to a fluence of 8 × 1014 ions/cm2. The irradiated samples were characterized using grazing incidence X-ray diffraction technique. The results reveal that Lu2(Ti2-xLux)O7-x/2 samples undergo significant amorphization and lattice swelling upon irradiation. Specifically, the amorphization process is predominantly driven by ballistic nuclear energy deposition of Ar11+ ions at this energy regime, which can be well described by a direct-impact/defect-stimulated model. Both the amorphization fraction and the relative variation of lattice parameter decrease with increasing x, showing a strong dependence on the chemical composition. The results are then discussed in the framework of the structural disorder and recovery ability from damage, applying an atomic layer model.

  10. Parametric Methods for Dynamic 11C-Phenytoin PET Studies.

    PubMed

    Mansor, Syahir; Yaqub, Maqsood; Boellaard, Ronald; Froklage, Femke E; de Vries, Anke; Bakker, Esther D M; Voskuyl, Rob A; Eriksson, Jonas; Schwarte, Lothar A; Verbeek, Joost; Windhorst, Albert D; Lammertsma, Adriaan A

    2017-03-01

    In this study, the performance of various methods for generating quantitative parametric images of dynamic 11 C-phenytoin PET studies was evaluated. Methods: Double-baseline 60-min dynamic 11 C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were generated using Logan plot analysis, a basis function method, and spectral analysis. Parametric distribution volume (V T ) and influx rate ( K 1 ) were compared with those obtained from nonlinear regression analysis of time-activity curves. In addition, global and regional test-retest (TRT) variability was determined for parametric K 1 and V T values. Results: Biases in V T observed with all parametric methods were less than 5%. For K 1 , spectral analysis showed a negative bias of 16%. The mean TRT variabilities of V T and K 1 were less than 10% for all methods. Shortening the scan duration to 45 min provided similar V T and K 1 with comparable TRT performance compared with 60-min data. Conclusion: Among the various parametric methods tested, the basis function method provided parametric V T and K 1 values with the least bias compared with nonlinear regression data and showed TRT variabilities lower than 5%, also for smaller volume-of-interest sizes (i.e., higher noise levels) and shorter scan duration. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

  11. K2-232 b: a transiting warm Saturn on an eccentric P = 11.2 d orbit around a V = 9.9 star

    NASA Astrophysics Data System (ADS)

    Brahm, R.; Espinoza, N.; Jordán, A.; Rojas, F.; Sarkis, P.; Díaz, M. R.; Rabus, M.; Drass, H.; Lachaume, R.; Soto, M. G.; Jenkins, J. S.; Jones, M. I.; Henning, Th; Pantoja, B.; Vučković, M.

    2018-06-01

    We report the discovery of K2-232 b using photometric data of the Kepler K2 satellite coupled with ground-based spectroscopic observations. K2-232 b has a mass of MP = 0.397 ± 0.037 MJ, a radius of RP = 1.00 ± 0.020 RJ, and a moderately low equilibrium temperature of Teq = 1030 ± 15 K due to its relatively large star-planet separation of a = 0.1036 au. K2-232 b orbits its bright (V = 9.9) late F-type host star in an eccentric orbit (e = 0.258 ± 0.025) every 11.2 d, and is one of only four well-characterized warm Jupiters having host stars brighter than V = 10. We estimate a heavy element content of 20 ± 7 M⊕ for K2-232 b, which is consistent with standard models of giant planet formation. The bright host star of K2-232 b makes this system a well-suited target for detailed follow-up observations that will aid in the study of the atmospheres and orbital evolution of giant planets at moderate separations from their host stars.

  12. Invited Article: High resolution angle resolved photoemission with tabletop 11 eV laser

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    He, Yu; Vishik, Inna M.; Yi, Ming

    2016-01-15

    We developed a table-top vacuum ultraviolet (VUV) laser with 113.778 nm wavelength (10.897 eV) and demonstrated its viability as a photon source for high resolution angle-resolved photoemission spectroscopy (ARPES). This sub-nanosecond pulsed VUV laser operates at a repetition rate of 10 MHz, provides a flux of 2 × 10{sup 12} photons/s, and enables photoemission with energy and momentum resolutions better than 2 meV and 0.012 Å{sup −1}, respectively. Space-charge induced energy shifts and spectral broadenings can be reduced below 2 meV. The setup reaches electron momenta up to 1.2 Å{sup −1}, granting full access to the first Brillouin zone ofmore » most materials. Control over the linear polarization, repetition rate, and photon flux of the VUV source facilitates ARPES investigations of a broad range of quantum materials, bridging the application gap between contemporary low energy laser-based ARPES and synchrotron-based ARPES. We describe the principles and operational characteristics of this source and showcase its performance for rare earth metal tritellurides, high temperature cuprate superconductors, and iron-based superconductors.« less

  13. Measurement of elliptic flow of light nuclei at √{sN N}=200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV at the BNL Relativistic Heavy Ion Collider

    NASA Astrophysics Data System (ADS)

    Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Attri, A.; Averichev, G. S.; Bai, X.; Bairathi, V.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandenburg, J. D.; Brandin, A. V.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chatterjee, A.; Chattopadhyay, S.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; di Ruzza, B.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Du, C. M.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Engelage, J.; Eppley, G.; Esha, R.; Evdokimov, O.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, S.; Gupta, A.; Guryn, W.; Hamad, A. I.; Hamed, A.; Haque, R.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Horvat, S.; Huang, T.; Huang, X.; Huang, B.; Huang, H. Z.; Huck, P.; Humanic, T. J.; Igo, G.; Jacobs, W. W.; Jang, H.; Jentsch, A.; Jia, J.; Jiang, K.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z. H.; Kikoła, D. P.; Kisel, I.; Kisiel, A.; Kochenda, L.; Koetke, D. D.; Kosarzewski, L. K.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kumar, L.; Lamont, M. A. C.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, X.; Li, C.; Li, X.; Li, Y.; Li, W.; Lin, T.; Lisa, M. A.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, X.; Ma, R.; Ma, G. L.; Ma, Y. G.; Ma, L.; Magdy, N.; Majka, R.; Manion, A.; Margetis, S.; Markert, C.; Matis, H. S.; McDonald, D.; McKinzie, S.; Meehan, K.; Mei, J. C.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nandi, B. K.; Nasim, Md.; Nayak, T. K.; Nigmatkulov, G.; Niida, T.; Nogach, L. V.; Noh, S. Y.; Novak, J.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V. A.; Olvitt, D.; Page, B. S.; Pak, R.; Pan, Y. X.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pile, P.; Pluta, J.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Pruthi, N. K.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Raniwala, R.; Raniwala, S.; Ray, R. L.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sarkar, A.; Schambach, J.; Scharenberg, R. P.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Seger, J.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, M. K.; Sharma, B.; Shen, W. Q.; Shi, Z.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Singha, S.; Skoby, M. J.; Smirnov, N.; Smirnov, D.; Solyst, W.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stepanov, M.; Stock, R.; Strikhanov, M.; Stringfellow, B.; Sumbera, M.; Summa, B.; Sun, X. M.; Sun, Z.; Sun, Y.; Surrow, B.; Svirida, D. N.; Tang, Z.; Tang, A. H.; Tarnowsky, T.; Tawfik, A.; Thäder, J.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Todoroki, T.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; van Nieuwenhuizen, G.; Vandenbroucke, M.; Varma, R.; Vasiliev, A. N.; Vertesi, R.; Videbæk, F.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, Y.; Wang, G.; Wang, J. S.; Wang, H.; Wang, Y.; Wang, F.; Webb, G.; Webb, J. C.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y.; Xiao, Z. G.; Xie, W.; Xie, G.; Xin, K.; Xu, H.; Xu, Z.; Xu, J.; Xu, Y. F.; Xu, Q. H.; Xu, N.; Yang, Y.; Yang, S.; Yang, C.; Yang, Y.; Yang, Y.; Yang, Q.; Ye, Z.; Ye, Z.; Yepes, P.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, J.; Zhang, Y.; Zhang, X. P.; Zhang, Z.; Zhang, J. B.; Zhang, S.; Zhang, S.; Zhang, J.; Zhao, J.; Zhong, C.; Zhou, L.; Zhu, X.; Zoulkarneeva, Y.; Zyzak, M.; STAR Collaboration

    2016-09-01

    We present measurements of second-order azimuthal anisotropy (v2) at midrapidity (|y |<1.0 ) for light nuclei d ,t ,3He (for √{sN N}=200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV) and antinuclei d ¯ (√{sN N}=200 , 62.4, 39, 27, and 19.6 GeV) and ¯3He (√{sN N}=200 GeV) in the STAR (Solenoidal Tracker at RHIC) experiment. The v2 for these light nuclei produced in heavy-ion collisions is compared with those for p and p ¯. We observe mass ordering in nuclei v2(pT) at low transverse momenta (pT<2.0 GeV/c ). We also find a centrality dependence of v2 for d and d ¯. The magnitude of v2 for t and 3He agree within statistical errors. Light-nuclei v2 are compared with predictions from a blast-wave model. Atomic mass number (A ) scaling of light-nuclei v2(pT) seems to hold for pT/A <1.5 GeV /c . Results on light-nuclei v2 from a transport-plus-coalescence model are consistent with the experimental measurements.

  14. National Dam Safety Program. Alpina Dam (Inventory Number NY 778), St. Lawrence River Basin, Lewis County, New York. Phase I Inspection Report,

    DTIC Science & Technology

    1980-02-14

    LI z ma LiA a 0 4A4 Idd 0. 0a 4J 00 0 0) ac 4) w 0 - V/) 0 ~ . 0 zV -w o ~ = go -j- W- zwI - In0 0 L iz ma ~ 5 w sUs Li co ~LA.Z ts Al 0m z 0 w z Lij 0...CP= .63 VOL= 1.00 9. 32. 65. 1#4. 147. 192. 238. 281 . 317. 344. 361. 376. 368. 356. 322. 295. 276. 247. ZZ6. 267. 196. 173. 159. 145. 133. 122. 111

  15. Dr. von Braun Relaxes After the Successful Launch of Apollo 11

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Wernher von Braun, first director of the Marshall Space Flight Center, relaxes following the successful launch of the Saturn V carrying Apollo 11 to the moon. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

  16. Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population.

    PubMed

    Hussain, Iqra; Tasneem, Fareeda; Umer, Muhammed; Pervaiz, Ayesha; Raza, Muslim; Arshad, Muhammad Imran; Shahzad, Naveed

    2017-04-24

    The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively. The viruses remain latent primarily in reno-urinary tract, reactivating only in case of a compromised immune system. The seroepidemiology and molecular prevalence of BKPyV and JCPyV have been widely studied both in healthy and immunocompromised patients worldwide. However, data regarding the prevalence of these viruses in the immunocompetent or apparently healthy Pakistani population is lacking. Herein, we present the first ever report on quantitative prevalence of BKPyV and JCPyV in the peripheral blood of a randomly selected cohort of healthy Pakistani population. A total of 266 whole blood samples were examined. The subjects were divided into three age groups: ≤ 25 years (young), 26-50 years (middle) and ≥ 51 years (elder). Absolute real time PCR assay was designed to quantify the BKPyV and JCPyV viral copy numbers in the range of 10 6 to 10 0 copies/mL. Overall, BKPyV was detected in 27.1% (72/266) individuals while JCPyV in 11.6% (31/266) indicating significant difference (p < 0.005) in the distribution of these two viruses. The prevalence of BKPyV significantly decreased from 51% (49/96) in young age group to 8.2% (7/85) in eldest age group. Whereas, JCPyV positivity rate slightly increased from 8.3% (8/96) in young age group to 11.8% (10/85) in elder age group. The median viral load was calculated as 6.2 log and 3.38 log copies/mL of blood for BKPyV and JCPyV, respectively. Notably, no significant difference in viral load of either of the subtypes was found between different age groups. The current study provides an important baseline data on the prevalence and viral load of circulating BKPyV and JCPyV in Pakistani population. The prevalence and viral load of BKPyV was comparatively higher than JCPyV. The prevalence of BKPyV significantly decreased with increase in

  17. Integrated cosmic muon flux in the zenith angle range 0 < cosθ < 0.37 for momentum threshold up to 11.6 GeV/c

    NASA Astrophysics Data System (ADS)

    Fujii, Hirofumi; Hara, Kazuhiko; Hayashi, Kohei; Kakuno, Hidekazu; Kodama, Hideyo; Nagamine, Kanetada; Sato, Kazuyuki; Sato, Kotaro; Kim, Shin-Hong; Suzuki, Atsuto; Takahashi, Kazuki; Takasaki, Fumihiko

    2017-12-01

    We have measured the cosmic muon flux in the zenith angle range {<} cos θ {<} 0.37 with a detector comprising planes of scintillator hodoscope bars and iron blocks inserted between them. The muon ranges for up to 9.5 m-thick iron blocks allow the provision of muon flux data integrated over corresponding threshold momenta up to 11.6 GeV/c. Such a dataset covering the horizontal direction is extremely useful for a technique called muon radiography, where the mass distribution inside a large object is investigated from the cosmic muon distribution measured behind the object.

  18. NASA Administrator Dan Goldin speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA Administrator Daniel S. Goldin (right) addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex, with seating under an unused Saturn V rocket like those that powered the Apollo launches . This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

  19. 45 CFR 60.11 - Reporting adverse actions on clinical privileges.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (5 U.S.C. 552a note), (v) Date of birth, (vi) Name of each professional school attended and year of... 45 Public Welfare 1 2012-10-01 2012-10-01 false Reporting adverse actions on clinical privileges. 60.11 Section 60.11 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION...

  20. 45 CFR 60.11 - Reporting adverse actions on clinical privileges.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (5 U.S.C. 552a note), (v) Date of birth, (vi) Name of each professional school attended and year of... 45 Public Welfare 1 2010-10-01 2010-10-01 false Reporting adverse actions on clinical privileges. 60.11 Section 60.11 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION...

  1. 45 CFR 60.11 - Reporting adverse actions on clinical privileges.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (5 U.S.C. 552a note), (v) Date of birth, (vi) Name of each professional school attended and year of... 45 Public Welfare 1 2011-10-01 2011-10-01 false Reporting adverse actions on clinical privileges. 60.11 Section 60.11 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION...

  2. Dignitaries Await Apollo 11 Lift Off

    NASA Technical Reports Server (NTRS)

    1969-01-01

    From the right, NASA administrator, Dr. Thomas O. Paine talks with U.S. Vice President Spiro T. Agnew while awaiting the launch of Saturn V (AS-506) that carried the Apollo 11 spacecraft to the Moon for man's historic first landing on the lunar surface. At center is astronaut William Anders, a member of the first crew to orbit the moon during the Apollo 8 mission. At left is Lee B. James, director of Program Management at the NASA Marshall Space Flight Center (MSFC) where the Saturn V was developed. The craft lifted off from launch pad 39 at Kennedy Space Flight Center (KSC) on July 16, 1969. The moon bound crew included astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (M) pilot. The mission finalized with splashdown in the Pacific Ocean on July 24, 1969. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  3. Conception and characterization of a virtual coplanar grid for a 11×11 pixelated CZT detector

    NASA Astrophysics Data System (ADS)

    Espagnet, Romain; Frezza, Andrea; Martin, Jean-Pierre; Hamel, Louis-André; Després, Philippe

    2017-07-01

    Due to the low mobility of holes in CZT, commercially available detectors with a relatively large volume typically use a pixelated anode structure. They are mostly used in imaging applications and often require a dense electronic readout scheme. These large volume detectors are also interesting for high-sensitivity applications and a CZT-based blood gamma counter was developed from a 20×20×15 mm3 crystal available commercially and having a 11×11 pixelated readout scheme. A method is proposed here to reduce the number of channels required to use the crystal in a high-sensitivity counting application, dedicated to pharmacokinetic modelling in PET and SPECT. Inspired by a classic coplanar anode, an implementation of a virtual coplanar grid was done by connecting the 121 pixels of the detector to form intercalated bands. The layout, the front-end electronics and the characterization of the detector in this 2-channel anode geometry is presented. The coefficients required to compensate for electron trapping in CZT were determined experimentally to improve the performance. The resulting virtual coplanar detector has an intrinsic efficiency of 34% and an energy resolution of 8% at 662 keV. The detector's response was linear between 80 keV and 1372 keV. This suggests that large CZT crystals offer an excellent alternative to scintillation detectors for some applications, especially those where high-sensitivity and compactness are required.

  4. AV59M KCNJ11 gene mutation leading to intermediate DEND syndrome in a Chinese child.

    PubMed

    Sang, Yanmei; Ni, Guichen; Gu, Yi; Liu, Min

    2011-01-01

    Heterozygous activating mutations in the KCNJ11 gene can cause permanent and transient neonatal diabetes. In the present study, we sequenced the KCNJ11 gene in a Chinese boy diagnosed with permanent neonatal diabetes mellitus (PNDM) and also in his parents. A heterozygous 175G > A (V59M) mutation was identified in the patient, while no KCNJ11 gene mutations were found in his parents, indicating that this mutation is de novo. The patient with the V59M mutation successfully switched from insulin injections to oral glibenclamide; 2 years of follow-up revealed that the patient had intermediate developmental delay, epilepsy and neonatal diabetes (DEND) syndrome. This is the first patient who is reported to have iDEND syndrome due to KCNJ11 V59M mutation in China.

  5. KEY COMPARISON Bilateral comparison of 1.018 V and 10 V standards between the NSAI-NML (Ireland) and the BIPM, March to April 2010 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    NASA Astrophysics Data System (ADS)

    Power, O.; Solve, S.; Chayramy, R.; Stock, M.

    2010-01-01

    As a part of the ongoing BIPM key comparisons BIPM.EM-K11.a and b, a comparison of the 1.018 V and 10 V voltage reference standards of the BIPM and of the National Standards Authority of Ireland-National Metrology Laboratory (NSAI-NML), Dublin, Ireland, was carried out from March to April 2010. Two BIPM Zener diode-based travelling standards were transported by freight to NSAI-NML. At NSAI-NML, the reference standard for DC voltage is maintained at the 10 V level by means of a group of characterized Zener diode-based electronic voltage standards. The output EMF of each travelling standard, at the 10 V output terminals, was measured by direct comparison with the group standard. Measurements of the output EMF of the travelling standards at the 1.018 V output terminals were made using a potentiometer, standardized against the local 10 V reference standard. At the BIPM, the travelling standards were calibrated at both voltages before and after the measurements at NSAI-NML, using the BIPM Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages on internal temperature and ambient pressure. The comparison results show that the voltage standards maintained by NSAI-NML and the BIPM were equivalent, within their stated expanded uncertainties, on the mean date of the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  6. Three-Dimensional Innervation Zone Imaging from Multi-Channel Surface EMG Recordings.

    PubMed

    Liu, Yang; Ning, Yong; Li, Sheng; Zhou, Ping; Rymer, William Z; Zhang, Yingchun

    2015-09-01

    There is an unmet need to accurately identify the locations of innervation zones (IZs) of spastic muscles, so as to guide botulinum toxin (BTX) injections for the best clinical outcome. A novel 3D IZ imaging (3DIZI) approach was developed by combining the bioelectrical source imaging and surface electromyogram (EMG) decomposition methods to image the 3D distribution of IZs in the target muscles. Surface IZ locations of motor units (MUs), identified from the bipolar map of their MU action potentials (MUAPs) were employed as a prior knowledge in the 3DIZI approach to improve its imaging accuracy. The performance of the 3DIZI approach was first optimized and evaluated via a series of designed computer simulations, and then validated with the intramuscular EMG data, together with simultaneously recorded 128-channel surface EMG data from the biceps of two subjects. Both simulation and experimental validation results demonstrate the high performance of the 3DIZI approach in accurately reconstructing the distributions of IZs and the dynamic propagation of internal muscle activities in the biceps from high-density surface EMG recordings.

  7. THREE-DIMENSIONAL INNERVATION ZONE IMAGING FROM MULTI-CHANNEL SURFACE EMG RECORDINGS

    PubMed Central

    LIU, YANG; NING, YONG; LI, SHENG; ZHOU, PING; RYMER, WILLIAM Z.; ZHANG, YINGCHUN

    2017-01-01

    There is an unmet need to accurately identify the locations of innervation zones (IZs) of spastic muscles, so as to guide botulinum toxin (BTX) injections for the best clinical outcome. A novel 3-dimensional IZ imaging (3DIZI) approach was developed by combining the bioelectrical source imaging and surface electromyogram (EMG) decomposition methods to image the 3D distribution of IZs in the target muscles. Surface IZ locations of motor units (MUs), identified from the bipolar map of their motor unit action potentials (MUAPs) were employed as a prior knowledge in the 3DIZI approach to improve its imaging accuracy. The performance of the 3DIZI approach was first optimized and evaluated via a series of designed computer simulations, and then validated with the intramuscular EMG data, together with simultaneously recorded 128-channel surface EMG data from the biceps of two subjects. Both simulation and experimental validation results demonstrate the high performance of the 3DIZI approach in accurately reconstructing the distributions of IZs and the dynamic propagation of internal muscle activities in the biceps from high-density surface EMG recordings. PMID:26160432

  8. Word Frequency Analysis. MOS: 57H. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    8217 . -4 1a’ _________ Palms 1t. FLL& T - VI;:.P - -- S LtrTZE5 I Lu" I rprz l * 4 2lE p:Zn.uAwn PLCU4LLE 14 Piz;* I P RTICULAR 4 PZR1S 7 J _________ 2...I’ I VIn 1 fIV 7 IaIIA!’I TIP 2 1-111 L LAlT P i;10! S II*,s , 11- 1 L Ii1! p UIIIc tInlG Z :𔃻 S -W (INSf4 2 IZ 1111tE~ ;l ,’I I z a5T p Oil ’(1$I1...p --G 6 RIGGING- I~ V~. 1 5EL~ .1 50:L I SF AFY~~3!.rS_7I; 7 SAFETY I----c- 7 -- ss1 ’_F T_-------- 1 HPPI 7A! I1CEUE SCP .~LaG 3 SHUTWI ~ SC’~J’!LI

  9. Electrochemistry of 1,1'-bis(2,4-dialkylphosphetanyl)ferrocene and 1,1'-bis(2,5-dialkylphospholanyl)ferrocene ligands: free phosphines, metal complexes, and chalcogenides.

    PubMed

    Mandell, Chelsea L; Kleinbach, Shannon S; Dougherty, William G; Kassel, W Scott; Nataro, Chip

    2010-10-18

    The oxidative electrochemistries of a series of chiral bisphosphinoferrocene ligands, 1,1'-bis(2,4-dialkylphosphetanyl)ferrocene (FerroTANE) and 1,1'-bis(2,5-dialkylphospholanyl)ferrocene (FerroLANE), were examined. The reversibility of the oxidation is sensitive to the steric bulk of the alkyl groups. New transition metal compounds and phosphine chalcogenides of these ligands were prepared and characterized. X-ray crystal structures of 10 of these compounds are reported. The percent buried volume (%V(bur)) is a recently developed measurement based on crystallographic data that examines the steric bulk of N-heterocyclic carbene and phosphine ligands. The %V(bur) for the FerroTANE and FerroLANE structures with methyl or ethyl substituents suggests these ligands are similar in steric properties to 1,1'-bis(diphenylphosphino)ferrocene (dppf). In addition the %V(bur) has been found to correlate well with the Tolman cone angle for phosphine chalcogenides. The oxidative electrochemistries of the transition metal complexes occur at more positive potentials than the free ligands. While a similar positive shift is seen for the oxidative electrochemistries of the phosphine chalcogenides, the oxidation of the phosphine selenides does not occur at the iron center, but rather oxidation occurs at the selenium atoms.

  10. CAMAC driver for the RSX-11M V3 operating system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tippie, J. W.; Cannon, P. H.

    1977-01-01

    A driver for Kinetic Systems 3911A dedicated crate controller and 3992 serial highway driver for RSX-11M is described. The implementation includes a modified UCB structure. With this structure, multiple active I/O requests are supported to a single controller. The completion of an I/O request may be tied to external events via a WAIT-FOR-LAM command. Features of the driver include the ability to pass a list of FNA's in a single QIO call, serial highway overhead transparent at the QIO level, and special control commands to the driver passed in the FNA list. 1 figure.

  11. DES J0454-4448: discovery of the first luminous z ≥ 6 quasar from the Dark Energy Survey

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reed, S. L.; McMahon, R. G.; Banerji, M.

    We present the first results of a survey for high-redshift, z ≥ 6, quasars using izY multicolour photometric observations from the Dark Energy Survey (DES). Here we report the discovery and spectroscopic confirmation of the z AB, Y AB = 20.2, 20.2 (M 1450 = -26.5) quasar DES J0454-4448 with a redshift of z = 6.09±0.02 based on the onset of the Ly α forest and an H I near zone size of 4.1 +1.1 -1.2 proper Mpc. The quasar was selected as an i-band drop out with i-z = 2.46 and z AB < 21.5 from an area ofmore » ~300 deg 2. It is the brightest of our 43 candidates and was identified for spectroscopic follow-up solely based on the DES i-z and z-Y colours. The quasar is detected by WISE and has W1 AB = 19.68. The discovery of one spectroscopically confirmed quasar with 5.7 < z < 6.5 and zAB ≤ 20.2 is consistent with recent determinations of the luminosity function at z ~ 6. DES when completed will have imaged ~5000 deg 2 to Y AB = 23.0 (5σ point source) and we expect to discover 50–100 new quasars with z > 6 including 3–10 with z > 7 dramatically increasing the numbers of quasars currently known that are suitable for detailed studies.« less

  12. Lidocaine Injection in the Intramuscular Innervation Zone Can Effectively Treat Chronic Neck Pain Caused by MTrPs in the Trapezius Muscle.

    PubMed

    Xie, Peng; Qin, Bangyong; Yang, Fangjiu; Yu, Tian; Yu, Jin; Wang, Jiang; Zheng, Hong

    2015-01-01

    An increasing number of people suffer from neck pain due to life style and prolonged use of computers. Research has revealed that myofascial trigger points (MTrPs) and the intramuscular innervation zone (IZ) are involved in neck pain. MTrPs are induced mainly by IZ dysfunction of the affected skeletal muscle and the 2 do not overlap in location. The question is whether injection treatment in MTrPs or in the IZ is more effective to relieve MTrPs-associated pains. The precise location and body-surface map of the intramuscular IZ in the trapezius muscle and a clinical injection study in the IZ may provide a useful answer to the question. This study aimed to investigate the efficacy of lidocaine injection in the intramuscular IZ for the treatment of chronic neck pain caused by MTrPs in the trapezius muscle. Prospective observational study, approved by the local research ethics. University hospital, departments of Anesthesiology and Anatomy. First, for the determination of IZ distribution and body-surface mapping, a modified intramuscular Sihler's neural staining technique was applied to elucidate nerve distribution patterns of the trapezius muscle. Then, 120 patients with myofascial pain syndrome (MPS) of the trapezius muscle were randomly divided into 5 groups for analysis. Group 1 (n = 24) received injections of saline (0.9% NaCl) at the MTrPs. Group 2 (n = 24) received injections of 0.5% lidocaine at the MTrPs. Group 3 (n = 24) received injections of saline (0.9% NaCl) at the mid-upper trapezius (Point E). Group 4 (n = 24) received injections of 0.5% lidocaine at Point E. Group 5 (n = 24) received a combined injection of 0.5% lidocaine treatment at both Point E and the lower trapezius (Point F). The injection dose was 4 mL at each injection site. All patients received injections once a week for 4 weeks. The visual analogue scale (VAS) and the frequency of painful days per month (FPD) were obtained before treatment and at 2, 4, and 6 months after treatment. The

  13. Editorial: The publication of geoscientific model developments v1.1

    NASA Astrophysics Data System (ADS)

    Executive Editors, GMD

    2015-10-01

    Version 1.0 of the editorial of the EGU (European Geosciences Union) journal, Geoscientific Model Development (GMD), was published in 2013. In that editorial an assessment was made of the progress the journal had made since it started, and some revisions to the editorial policy were introduced. After 2 years of experience with this revised editorial policy there are a few required updates, refinements and clarifications, so here we present version 1.1 of the editorial. The most significant amendments relate to the peer-review criteria as presented in the Framework for GMD manuscript types, which is published as an appendix to this paper and also available on the GMD manuscript types webpage. We also slightly refine and update the Publication guide and introduce a self-contained code and data policy. The changes are summarised as follows: - All manuscript types are now required to include code or data availability paragraphs, and model code must always be made available (in the case of copyright or other legal issues, to the editor at a minimum). - The role of evaluation in GMD papers is clarified, and a separate evaluation paper type is introduced. Model descriptions must already be published or in peer review when separate evaluation papers are submitted. - Observationally derived data should normally be published in a data journal rather than in GMD. Syntheses of data which were specifically designed for tasks such as model boundary conditions or direct evaluation of model output may, however, be published in GMD. - GMD publishes a broad range of different kinds of models, and this fact is now more explicitly acknowledged. - The main changes to the Publication guide are the addition of guidelines for editors when assessing papers at the initial review stage. Before sending papers for peer review, editors are required to make sure that papers comply with the Framework for GMD paper types and to carefully consider the topic of plagiarism. - A new appendix, the GMD

  14. 43 CFR 11.11 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Purpose. 11.11 Section 11.11 Public Lands: Interior Office of the Secretary of the Interior NATURAL RESOURCE DAMAGE ASSESSMENTS Introduction § 11.11... natural resource damages. The results of an assessment performed by a Federal or State natural resource...

  15. 43 CFR 11.11 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Purpose. 11.11 Section 11.11 Public Lands: Interior Office of the Secretary of the Interior NATURAL RESOURCE DAMAGE ASSESSMENTS Introduction § 11.11... natural resource damages. The results of an assessment performed by a Federal or State natural resource...

  16. Application of Multi-Frequency Modulation (MFM) for High-Speed Data Communications to a Voice Frequency Channel

    DTIC Science & Technology

    1990-06-01

    reader is cautioned that computer programs developed in this research may not have been exercised for all cases of interest. While every effort has been...Source of Funding Numbers _. Program Element No Project No I Task No I Work Unit Accession No 11 Title (Include security classflcation) APPLICATION OF...formats. Previous applications of these encoding formats were on industry standard computers (PC) over a 16-20 klIz channel. This report discusses the

  17. Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature.

    PubMed

    Brunetti, Orazio; Imbrici, Paola; Botti, Fabio Massimo; Pettorossi, Vito Enrico; D'Adamo, Maria Cristina; Valentino, Mario; Zammit, Christian; Mora, Marina; Gibertini, Sara; Di Giovanni, Giuseppe; Muscat, Richard; Pessia, Mauro

    2012-09-01

    Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by myokymia and attacks of ataxic gait often precipitated by stress. Several genetic mutations have been identified in the Shaker-like K(+) channel Kv1.1 (KCNA1) of EA1 individuals, including V408A, which result in remarkable channel dysfunction. By inserting the heterozygous V408A, mutation in one Kv1.1 allele, a mouse model of EA1 has been generated (Kv1.1(V408A/+)). Here, we investigated the neuromuscular transmission of Kv1.1(V408A/+) ataxic mice and their susceptibility to physiologically relevant stressors. By using in vivo preparations of lateral gastrocnemius (LG) nerve-muscle from Kv1.1(+/+) and Kv1.1(V408A/+) mice, we show that the mutant animals exhibit spontaneous myokymic discharges consisting of repeated singlets, duplets or multiplets, despite motor nerve axotomy. Two-photon laser scanning microscopy from the motor nerve, ex vivo, revealed spontaneous Ca(2+) signals that occurred abnormally only in preparations dissected from Kv1.1(V408A/+) mice. Spontaneous bursting activity, as well as that evoked by sciatic nerve stimulation, was exacerbated by muscle fatigue, ischemia and low temperatures. These stressors also increased the amplitude of compound muscle action potential. Such abnormal neuromuscular transmission did not alter fiber type composition, neuromuscular junction and vascularization of LG muscle, analyzed by light and electron microscopy. Taken together these findings provide direct evidence that identifies the motor nerve as an important generator of myokymic activity, that dysfunction of Kv1.1 channels alters Ca(2+) homeostasis in motor axons, and also strongly suggest that muscle fatigue contributes more than PNS fatigue to exacerbate the myokymia/neuromyotonia phenotype. More broadly, this study points out that juxtaparanodal K(+) channels composed of Kv1.1 subunits exert an important role in dampening the excitability of motor nerve axons during

  18. Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature

    PubMed Central

    Brunetti, Orazio; Imbrici, Paola; Botti, Fabio Massimo; Pettorossi, Vito Enrico; D'Adamo, Maria Cristina; Valentino, Mario; Zammit, Christian; Mora, Marina; Gibertini, Sara; Di Giovanni, Giuseppe; Muscat, Richard; Pessia, Mauro

    2012-01-01

    Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by myokymia and attacks of ataxic gait often precipitated by stress. Several genetic mutations have been identified in the Shaker-like K+ channel Kv1.1 (KCNA1) of EA1 individuals, including V408A, which result in remarkable channel dysfunction. By inserting the heterozygous V408A, mutation in one Kv1.1 allele, a mouse model of EA1 has been generated (Kv1.1V408A/+). Here, we investigated the neuromuscular transmission of Kv1.1V408A/+ ataxic mice and their susceptibility to physiologically relevant stressors. By using in vivo preparations of lateral gastrocnemius (LG) nerve–muscle from Kv1.1+/+ and Kv1.1V408A/+ mice, we show that the mutant animals exhibit spontaneous myokymic discharges consisting of repeated singlets, duplets or multiplets, despite motor nerve axotomy. Two-photon laser scanning microscopy from the motor nerve, ex vivo, revealed spontaneous Ca2 + signals that occurred abnormally only in preparations dissected from Kv1.1V408A/+ mice. Spontaneous bursting activity, as well as that evoked by sciatic nerve stimulation, was exacerbated by muscle fatigue, ischemia and low temperatures. These stressors also increased the amplitude of compound muscle action potential. Such abnormal neuromuscular transmission did not alter fiber type composition, neuromuscular junction and vascularization of LG muscle, analyzed by light and electron microscopy. Taken together these findings provide direct evidence that identifies the motor nerve as an important generator of myokymic activity, that dysfunction of Kv1.1 channels alters Ca2 + homeostasis in motor axons, and also strongly suggest that muscle fatigue contributes more than PNS fatigue to exacerbate the myokymia/neuromyotonia phenotype. More broadly, this study points out that juxtaparanodal K+ channels composed of Kv1.1 subunits exert an important role in dampening the excitability of motor nerve axons during fatigue or

  19. Fotometria dell'asteroide (35396) 1997 XF11

    NASA Astrophysics Data System (ADS)

    Foglia, Sergio

    2005-04-01

    Radar and photometric observations of (35396) 1997 XF11 were made during its close approach with the Earth in 2002. The photometric parameters found are: period of rotation = 3.2567±0.0001 hours, light curve amplitude = 0.71 mag., (V-R) = 0.5 and absolute magnitude H = 17.0±0.4.

  20. Sequential Quadratic Programming Algorithms for Optimization

    DTIC Science & Technology

    1989-08-01

    quadratic program- ma ng (SQ(2l ) aIiatain.seenis to be relgarded aIs tie( buest choice for the solution of smiall. dlense problema (see S tour L)toS...For the step along d, note that a < nOing + 3 szH + i3.ninA A a K f~Iz,;nd and from Id1 _< ,,, we must have that for some /3 , np , 11P11 < dn"p. 5.2...Nevertheless, many of these problems are considered hard to solve. Moreover, for some of these problems the assumptions made in Chapter 2 to establish the

  1. LADEE/Minotaur V Rocket

    NASA Image and Video Library

    2013-09-06

    The doors of the gantry support structure are opened to reveal the Minotaur V rocket on Pad 0B at the Mid-Atlantic Regional Spaceport (MARS) at NASA's Wallops Flight Facility, Friday, Sept. 6, 2013 in Virginia. The Minotaur V will launch NASA's Lunar Atmosphere and Dust Environment Explorer (LADEE). LADEE is a robotic mission that will orbit the moon where it will provide unprecedented information about the environment around the moon and give scientists a better understanding of other planetary bodies in our solar system and beyond. LADEE is scheduled to launch at 11:27 p.m. Friday, Sept. 6, from NASA's Wallops Flight Facility. Photo Credit: (NASA/Carla Cioffi)

  2. Taxifolin inhibits rat and human 11β-hydroxysteroid dehydrogenase 2.

    PubMed

    Wu, Chengyun; Cao, Shuyan; Hong, Tingting; Dong, Yaoyao; Li, Chao; Wang, Qiufan; Sun, Jianliang; Ge, Ren-Shan

    2017-09-01

    Taxifolin is a flavonoid in food plants. Kidney 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) is an NAD + -dependent oxidase that inactivates glucocorticoid cortisol (human) or corticosterone (rodents) into biologically inert 11 keto glucocorticoids. The present study investigated the effects of taxifolin on rat and human kidney microsomal 11β-HSD2. Taxifolin noncompetitively inhibited rat and human 11β-HSD2 against steroid substrates, with IC 50 values of 33.08 and 13.14μM, respectively. Administration of 5 and 10mg/kg taxifolin for 30min ex vivo inhibited 11β-HSD2 significantly and also in vivo decreased cortisol metabolism, as shown in the significant increase of area under curve (AUC). This result shows that taxifolin is a potent 11β-HSD2 inhibitor, possibly causing side effects. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Plastic Behavior of Al-Li-X Alloys

    DTIC Science & Technology

    1991-07-01

    Ifuneo epr (stem lAig IC 30 IZ v)20 00 100100100 Life (hours) 10 -8 1 1 1 U 8090 Peak Aged -d 8090 Under Aged cz1-9 cc 0 8090 Peak AgedI o 95%R.H. 4000...12), p 768, 1980. 60. F. Laves and H. Witte, Metallwirtschaft, L4, p 645, 1935 ; 75. F. W. Gayle and J. B. Vanderande, Scr. Metall., 18, p 15, p 840

  4. Potential Environmental Impacts of Army Laser Operations: An Overview

    DTIC Science & Technology

    1983-06-01

    Cecilia Doughty for her professional and timely editorial assistance and to Lisa North for her exemplary...8217"- •- .. ... . . ... .. ........ .. ....... .. . ... ° • ... .. ... .., ... . . .. ... .. .. ... .......... ... .. ... ..,. j .. ... .. . .. ... ... f ... ... ..... . ........ . .,C ... , SI,,I POTENTIAL ENVIRONMENTAL IMPACTS OF ARMY LASER OPERATIONS AN OVERVIEW 1. INTRO...Sciences Laboratory, White Sands Missile Range, New Mexico 88002. 10 -~~ - Iz2 L 0 *U 4 v *; LL -00 cc . J 0~ Li FI. !:aa al Go 1 I U.U ofc W u o -

  5. Analysis of the v2, v4 Infrared Hot Bands and v1 CARS Spectrum of 34S16O3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barber, Jeffrey B.; Chrysostom, Engelene; Masiello, Tony

    2003-04-01

    High-resolution (0.0015 cm-1) infrared spectroscopy has been used to study the 34S16O3 IR-active hot bands originating from the v2 and v4 bending mode levels and terminating in the states 2v2 (l=0), v2+v4 (l=+1), and 2v4 (1=0,+2). The upper states are strongly coupled via Fermi resonance and indirect Coriolis interactions to the v1 symmetric stretching mode levels that are only directly accessible from the ground state via a Raman-active transition. A Coherent anti-Stokes Raman (CARS) spectrum of v1 for 34S16O3 is presented which is dramatically different from the corresponding one for 32S16O3. From the infrared transitions, accurate rovibrational constants are deducedmore » for all the mixed states, leading to deperturbed values for v1, a1B, and a1C of 1064.920(84), 0.000 834 5 (54), and 0.000 410(11) cm-1 respectively. The uncertainties in the last digits are shown in parentheses and represent two standard deviations. These parameters reproduce the unresolved Q-branch contour of the C ARS spectrum very well. Various other rotational and vibrational parameters have been determined, leading to values of Be= 0.349 760 6(33) cm-1 and re= 141.734 70(68) pm, values that are identical (within experimental error) to those found for 32S16O3.« less

  6. Rapid screening and structural elucidation of a novel sibutramine analogue in a weight loss supplement: 11-desisobutyl-11-benzylsibutramine.

    PubMed

    Mans, Daniel J; Gucinski, Ashley C; Dunn, Jamie D; Gryniewicz-Ruzicka, Connie M; Mecker-Pogue, Laura C; Kao, Jeff L-F; Ge, Xia

    2013-09-01

    A novel analogue of sibutramine, 11-desisobutyl-11-benzylsibutramine, has been discovered. During routine ion mobility spectrometry (IMS) screening of a weight loss supplement collected at an US FDA import operation facility an unknown peak was observed. Further analysis of the supplement by liquid chromatography-mass spectrometry (LC-MS) and high resolution mass spectrometry revealed an unknown peak with a relative retention time of 1.04 with respect to sibutramine and a predicted formula of C20H24NCl. In order to elucidate the analogue's structure, it was isolated from the supplement and characterized by tandem mass spectrometry and nuclear magnetic resonance (NMR), which revealed the analogue possessed a benzyl moiety at the 11 position in place of the isobutyl group associated with sibutramine. Copyright © 2013. Published by Elsevier B.V.

  7. Apollo 11 Astronauts In Prayer Within Quarantine Facility

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via a Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was taken to safety aboard the USS Hornet, where they were quartered in a mobile quarantine facility. Shown here is the Apollo 11 crew inside the quarantine facility as prayer is offered by Lt. Commander John Pirrto, USS Hornet Chaplain accompanied by U.S. President Richard Nixon (front right). With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  8. Measurement of the production cross section ratio σ(χ b2(1P)) / σ(χ b1(1P)) in pp collisions at √(s) = 8 TeV

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Khachatryan, Vardan

    2015-02-24

    Our measurement of the production cross section ratio σ(χ b2(1P))/σ(χ b1(1P)) is presented. The χ b1(1P) and χ b2(1P) bottomonium states, promptly produced in pp collisions at √(s) = 8 TeV , are detected by the CMS experiment at the CERN LHC through their radiative decays χ b1,2(1P)→Υ(1S)+γ. The emitted photons are measured through their conversion to e +e - pairs, whose reconstruction allows the two states to be resolved. The Υ(1S) is measured through its decay to two muons. An event sample corresponding to an integrated luminosity of 20.7 fb -1 is used to measure the cross section ratiomore » in a phase-space region defined by the photon pseudorapidity, |η γ|<1.0; the Υ(1S) rapidity, |y Υ|<1.5; and the Υ(1S) transverse momentum, 7T Υ<40 GeV . Finally, the cross section ratio shows no significant dependence on the Υ(1S) transverse momentum, with a measured average value of 0.85± 0.07 (stat + syst) ± 0.08 (BF), where the first uncertainty is the combination of the experimental statistical and systematic uncertainties and the second is from the uncertainty in the ratio of the χ b branching fractions.« less

  9. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 21 (Video Animation Systems Inc - Zytron Corporation).

    DTIC Science & Technology

    1985-01-01

    22202-4302 ; a NAM E 0- FUND’NG ’SPONSORING Bb OFFICE SYMBOL 9 PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER7 0 RGAN IZ A nON (if applicable) ’, fy Stare...CODES 18. SUBJECT TERMS (Continue on reverse if necessary and identify by block number) rIELD GROUP SUB-GROUP 9 ABSTRACT (Continue on reverse if necessary...used untl exhausted. SECURITY CLASSIFICATION OF THIS PAGE 86 3 18 135 ’- . * -’ -" LLJi -- <ZO z. I.D K Z. %.) v 0w 0- a La Z. L.-J. _ju j V) 9 , 1. caZ0 0

  10. Prolonged passive static stretching-induced innervation zone shift in biceps brachii.

    PubMed

    Ye, Xin; Beck, Travis W; Wages, Nathan P

    2015-05-01

    The purpose of this study was to examine the influence of a bout of repeated and prolonged passive static stretching on the innervation zone (IZ) location of the human biceps brachii muscle. Eleven men performed 12 sets of 100-s passive stretches on their biceps brachii. Before (Pre) and immediately after (Post) the stretching intervention, isometric strength was tested during the maximal voluntary contractions (MVCs) of the forearm flexors. The subjects also performed several separate isometric forearm flexion muscle actions at 30%, 50%, and 70% of their predetermined MVCs for examining the locations of the IZ at different contraction intensities. The IZ was identified through multi-channel surface electromyographic (EMG) recordings from a linear electrode array. The stretching intervention induced an average of 10% isometric strength loss for the forearm flexors (mean±SD: Pre-MVC vs. Post-MVC=332.12±59.40 N vs. 299.53±70.51 N; p<0.001). In addition, the average IZ shift was nearly 4.5 mm in average in the proximal direction. However, this shift was not specific to the contraction intensity. We believe that the IZ shift was caused by the elongation of the entire muscle-tendon unit in the proximal direction. Therefore, caution should be taken when using surface EMG technique to examine possible changes in the EMG variables after a stretching protocol, as these variables can be contaminated by the shift of the IZ.

  11. U.S. EPA, Pesticide Product Label, AGWAY BETASAN 12.5G, 11/29/1979

    EPA Pesticide Factsheets

    2011-04-21

    ... i"'n"'rtl'll' ',',l,-jIf)I,,'; N;If""""' 1"'"11'" Mflll1,f'''''V t:vl't."." M,II'If'''''V Pm,. M~,'I,. f'nvt" f'hvp,.n'·jll" It,. !"I;ml r" raf"l'v"""d,;l rlnd ;'WI,,.t I'. 1 W."lllrlfl, .... 71111111' ...

  12. Development of DSM-V and ICD-11: tendencies and potential of new classifications in psychiatry at the current state of knowledge.

    PubMed

    Möller, Hans-Jürgen

    2009-10-01

    A reason for the necessity to revise ICD-10 and DSM-IV is the increase of knowledge in the past 20 years, especially neurobiological knowledge. But is this increase of knowledge, for example in the field of neurogenetics, of such magnitude that a revision of the psychiatric classification is necessary and promises to be fruitful? The current plans for DSM-V or ICD-11, respectively, focus on different improvements. In this context also the introduction of a purely syndromatic/dimensional approach without including etiopathogenetic hypotheses, is discussed. A switch to such a dimensional approach, which was discussed among others in the DSM-V task force Deconstructing Psychosis, would be the most radical development. It could avoid many theoretical pre-assumptions about causal hypotheses, which are still associated with ICD-10 and DSM-IV. This would indeed increase the validity of psychiatric classification, but it would also reduce the information as compared to traditional diagnostic categories with all the current implications concerning etiopathogenesis, therapy and prognosis. Such a dimensional approach would also mean that the syndromes would have to be assessed in a standardized way for each person seeking help from the psychiatric service system or for each person undergoing psychiatric research. This would have to be a multi-dimensional assessment covering all syndromes existing within different psychiatric disorders. Based on the different aspects that must be considered in this context, a careful revision seems more advisable than a radical change of classification.

  13. Variability in the high energy gamma ray emission from Cyg X-3 over a two-year period (1983 - 1984) at E 4 x 10(11) eV

    NASA Technical Reports Server (NTRS)

    Cawley, M. F.; Fegan, D. J.; Gibbs, K.; Gorham, P. W.; Lamb, R. C.; Liebing, D. F.; Porter, N. A.; Stenger, V. J.; Weekes, T. C.; Williams, R. J.

    1985-01-01

    Cygnus X-3 is observed to emit gamma rays with energies in excess of 4 x 10 to the 11th power eV during two out of 9 observational categories over an 18 month time span. The emissions are observed at the 0.6 phase of the characteristic 4.8 hr light curve for this binary system. We estimate a peak flux at phase 0.6 of 5 x 10 to the minus 10th power photons cm-2s-1 at a software threshold of 8 x 10 to the 11th power eV for Oct/Nov 1983. A flux for the June 84 effect cannot be reliably calculated at present due to lack of Monte Carlo simulations for the energy range and spectral region. For the other 7 observational categories the observations are consistent with zero source emission. The light curve would appear to be variable on a time scale of a couple of weeks at these categories. Selection of compact images in accordance with Monte Carlo simulations combined with empirical optimization techniques have led to an enriched gamma ray light curve for the Oct/Nov 1983 data. Selection on the basis of shower orientation, however, has not led to any notable enhancement of the gamma ray content. Individual Cherenko images can be reliably sorted on an event by event basis into either proton-induced or photon-induced showers.

  14. Support Equipment Selection Analysis (SESA) for the Navy Standard Airborne Computer Set (AN/AYK-14(V)).

    DTIC Science & Technology

    1980-11-17

    111 - rb’" /JI- D.1 F. 1A.’ E I IJ~Ei]JF J I -126- HAEC-92-138 0 cz-: 00 CA a +. 9 11 11 118 0 rA. a , +, +.~ ’ q y 1 wI ~ 3- An~ii .03 -. VDI . 𔃾’ -127...32 - 2048 10 MHz +5 v - - 32 1024 10 MUz +5 v - lb - 1024 25 MHz +.76 v 224 - - 256 500 kHz +5 v (TTL) - 32 32 256 250 kHz +28 v - 32 32 286 250

  15. Photoluminescence emission spectra of Makrofol® DE 1-1 upon irradiation with ultraviolet radiation

    NASA Astrophysics Data System (ADS)

    El Ghazaly, M.; Aydarous, Abdulkadir

    Photoluminescence (PL) emission spectra of Makrofol® DE 1-1 (bisphenol-A based polycarbonate) upon irradiation with ultraviolet radiation of different wavelengths were investigated. The absorption-and attenuation coefficient measurements revealed that the Makrofol® DE 1-1 is characterized by high absorbance in the energy range 6.53-4.43 eV but for a lower energy than 4.43 eV, it is approximately transparent. Makrofol® DE 1-1 samples were irradiated with ultraviolet radiation of wavelength in the range from 250 (4.28 eV) to 400 (3.10 eV) nm in step of 10 nm and the corresponding photoluminescence (PL) emission spectra were measured with a spectrofluorometer. It is found that the integrated counts and the peak height of the photoluminescence emission (PL) bands are strongly correlated with the ultraviolet radiation wavelength. They are increased at the ultraviolet radiation wavelength 280 nm and have maximum at 290 nm, thereafter they decrease and diminish at 360 nm of ultraviolet wavelength. The position of the PL emission band peak was red shifted starting from 300 nm, which increased with the increase the ultraviolet radiation wavelength. The PL bandwidth increases linearly with the increase of the ultraviolet radiation wavelength. When Makrofol® DE 1-1 is irradiated with ultraviolet radiation of short wavelength (UVC), the photoluminescence emission spectra peaks also occur in the UVC but of a relatively longer wavelength. The current new findings should be considered carefully when using Makrofol® DE 1-1 in medical applications related to ultraviolet radiation.

  16. Prolonged Grief Disorder: Psychometric Validation of Criteria Proposed for DSM-V and ICD-11

    PubMed Central

    Prigerson, Holly G.; Horowitz, Mardi J.; Jacobs, Selby C.; Parkes, Colin M.; Aslan, Mihaela; Goodkin, Karl; Raphael, Beverley; Marwit, Samuel J.; Wortman, Camille; Neimeyer, Robert A.; Bonanno, George; Block, Susan D.; Kissane, David; Boelen, Paul; Maercker, Andreas; Litz, Brett T.; Johnson, Jeffrey G.; First, Michael B.; Maciejewski, Paul K.

    2009-01-01

    Background Bereavement is a universal experience, and its association with excess morbidity and mortality is well established. Nevertheless, grief becomes a serious health concern for a relative few. For such individuals, intense grief persists, is distressing and disabling, and may meet criteria as a distinct mental disorder. At present, grief is not recognized as a mental disorder in the DSM-IV or ICD-10. The goal of this study was to determine the psychometric validity of criteria for prolonged grief disorder (PGD) to enhance the detection and potential treatment of bereaved individuals at heightened risk of persistent distress and dysfunction. Methods and Findings A total of 291 bereaved respondents were interviewed three times, grouped as 0–6, 6–12, and 12–24 mo post-loss. Item response theory (IRT) analyses derived the most informative, unbiased PGD symptoms. Combinatoric analyses identified the most sensitive and specific PGD algorithm that was then tested to evaluate its psychometric validity. Criteria require reactions to a significant loss that involve the experience of yearning (e.g., physical or emotional suffering as a result of the desired, but unfulfilled, reunion with the deceased) and at least five of the following nine symptoms experienced at least daily or to a disabling degree: feeling emotionally numb, stunned, or that life is meaningless; experiencing mistrust; bitterness over the loss; difficulty accepting the loss; identity confusion; avoidance of the reality of the loss; or difficulty moving on with life. Symptoms must be present at sufficiently high levels at least six mo from the death and be associated with functional impairment. Conclusions The criteria set for PGD appear able to identify bereaved persons at heightened risk for enduring distress and dysfunction. The results support the psychometric validity of the criteria for PGD that we propose for inclusion in DSM-V and ICD-11. Please see later in the article for Editors

  17. IOS: PDP 11/45 formatted input/output task stacker and processer. [In MACRO-II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Koschik, J.

    1974-07-08

    IOS allows the programer to perform formated Input/Output at assembly language level to/from any peripheral device. It runs under DOS versions V8-O8 or V9-19, reading and writing DOS-compatible files. Additionally, IOS will run, with total transparency, in an environment with memory management enabled. Minimum hardware required is a 16K PDP 11/45, Keyboard Device, DISK (DK,DF, or DC), and Line Frequency Clock. The source language is MACRO-11 (3.3K Decimal Words).

  18. Visualization of structural evolution and phase distribution of a lithium vanadium oxide (Li 1.1V 3O 8) electrode via an operando and in situ energy dispersive X-ray diffraction technique

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Qing; Bruck, Andrea M.; Bock, David C.

    We present Li 1+nV 3O 8 (n = 0–0.2) has been extensively investigated as a cathode material for Li ion batteries because of its superior electrochemical properties including high specific energy and good rate capability. In this paper, a synchrotron based energy dispersive X-ray diffraction (EDXRD) technique was employed to profile the phase transitions and the spatial phase distribution of a Li 1.1V 3O 8 electrode during electrochemical (de)lithiation in situ and operando. As annealing temperature during the preparation of the Li 1.1V 3O 8 material has a strong influence on the morphology and crystallinity, and consequently influences the electrochemicalmore » outcomes of the material, Li 1.1V 3O 8 materials prepared at two different temperatures, 500 and 300°C (LVO500 and LVO300), were employed in this study. The EDXRD spectra of LVO500 and LVO300 cells pre-discharged at C/18, C/40 and C/150 were recorded in situ, and phase localization and relative intensity of the peaks were compared. For cells discharged at the C/18 rate, although α and β phases were distributed uniformly within the LVO500 electrode, they were localized on two sides of the LVO300 electrode. Discharging rates of C/40 and C/150 led to homogeneous β phase formation in both LVO500 and LVO300 electrodes. Furthermore, the phase distribution as a function of position and (de)lithiation extent was mapped operando as the LVO500 cell was (de)lithiated. In conclusion, the operando data indicate that (1) the lithiation reaction initiated from the side of the electrode facing the Li anode and proceeded towards the side facing the steel can, (2) during discharge the phase transformation from a Li-poor to a Li-rich α phase and the formation of a β phase can proceed simultaneously in the electrode after the first formation of a β phase, and (3) the structural evolution occurring during charging is not the reverse of that during discharge and takes place homogenously throughout the electrode.« less

  19. Visualization of structural evolution and phase distribution of a lithium vanadium oxide (Li 1.1V 3O 8) electrode via an operando and in situ energy dispersive X-ray diffraction technique

    DOE PAGES

    Zhang, Qing; Bruck, Andrea M.; Bock, David C.; ...

    2017-05-03

    We present Li 1+nV 3O 8 (n = 0–0.2) has been extensively investigated as a cathode material for Li ion batteries because of its superior electrochemical properties including high specific energy and good rate capability. In this paper, a synchrotron based energy dispersive X-ray diffraction (EDXRD) technique was employed to profile the phase transitions and the spatial phase distribution of a Li 1.1V 3O 8 electrode during electrochemical (de)lithiation in situ and operando. As annealing temperature during the preparation of the Li 1.1V 3O 8 material has a strong influence on the morphology and crystallinity, and consequently influences the electrochemicalmore » outcomes of the material, Li 1.1V 3O 8 materials prepared at two different temperatures, 500 and 300°C (LVO500 and LVO300), were employed in this study. The EDXRD spectra of LVO500 and LVO300 cells pre-discharged at C/18, C/40 and C/150 were recorded in situ, and phase localization and relative intensity of the peaks were compared. For cells discharged at the C/18 rate, although α and β phases were distributed uniformly within the LVO500 electrode, they were localized on two sides of the LVO300 electrode. Discharging rates of C/40 and C/150 led to homogeneous β phase formation in both LVO500 and LVO300 electrodes. Furthermore, the phase distribution as a function of position and (de)lithiation extent was mapped operando as the LVO500 cell was (de)lithiated. In conclusion, the operando data indicate that (1) the lithiation reaction initiated from the side of the electrode facing the Li anode and proceeded towards the side facing the steel can, (2) during discharge the phase transformation from a Li-poor to a Li-rich α phase and the formation of a β phase can proceed simultaneously in the electrode after the first formation of a β phase, and (3) the structural evolution occurring during charging is not the reverse of that during discharge and takes place homogenously throughout the electrode.« less

  20. Tempering Behavior of TiC-Reinforced SKD11 Steel Matrix Composite

    NASA Astrophysics Data System (ADS)

    Hwang, Ji-In; Kim, Seong Hoon; Heo, Yoon-Uk; Kim, Dae Ha; Hwang, Keum-Cheol; Suh, Dong-Woo

    2018-05-01

    TiC-reinforced SKD11 steel matrix composite, fabricated by a pressure infiltration casting, undergoes monotonic decrease in hardness as tempering temperature increases. Element mappings by TEM-EDS and thermodynamic calculation indicate that remarkable redistribution of V between the reinforcement and the steel matrix occurs by partial dissolution and re-precipitation of MC carbides upon casting process. The absence of secondary hardening is led by the enrichment of V in the reinforcement that reduces the V content in the steel matrix; this reduction in V content makes the precipitation of fine VC sluggish during the tempering.

  1. Tempering Behavior of TiC-Reinforced SKD11 Steel Matrix Composite

    NASA Astrophysics Data System (ADS)

    Hwang, Ji-In; Kim, Seong Hoon; Heo, Yoon-Uk; Kim, Dae Ha; Hwang, Keum-Cheol; Suh, Dong-Woo

    2018-03-01

    TiC-reinforced SKD11 steel matrix composite, fabricated by a pressure infiltration casting, undergoes monotonic decrease in hardness as tempering temperature increases. Element mappings by TEM-EDS and thermodynamic calculation indicate that remarkable redistribution of V between the reinforcement and the steel matrix occurs by partial dissolution and re-precipitation of MC carbides upon casting process. The absence of secondary hardening is led by the enrichment of V in the reinforcement that reduces the V content in the steel matrix; this reduction in V content makes the precipitation of fine VC sluggish during the tempering.

  2. IUTAM Symposium on Statistical Energy Analysis, 8-11 July 1997, Programme

    DTIC Science & Technology

    1997-01-01

    distribution is unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (Maximum200 words) This was the first international scientific gathering devoted...energy flow, continuum dynamics, vibrational energy, statistical energy analysis (SEA) 15. NUMBER OF PAGES 16. PRICE CODE INSECURITY... correlation v=V(ɘ ’• • determination of the correlation n^, =11^, (<?). When harmonic motion and time-average are considered, the following I

  3. DARPA (Defense Advanced Research Projects Agency) Review on EHF Devices Held in San Diego, California on 24-25 January 1989

    DTIC Science & Technology

    1989-04-01

    representing the official policies , either expressed or implied, of the Naval Ocean Systems Center or the U.S. Government. * I I NAVAL OCEAN SYSTEMS CENTER San...0 00 NNNc~ ___CI rI CncD I S zo I II C CC II I II....118 Iz oj z I. w z I w 0 z E 04 ww In jl ~ 11 u -i00 z~zo> Lu 0 F-J LL >- cr 0 - 0- M F-J CL z

  4. RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication.

    PubMed

    Ganaie, Safder S; Chen, Aaron Yun; Huang, Chun; Xu, Peng; Kleiboeker, Steve; Du, Aifang; Qiu, Jianming

    2018-04-15

    Human parvovirus B19 (B19V) expresses a single precursor mRNA (pre-mRNA), which undergoes alternative splicing and alternative polyadenylation to generate 12 viral mRNA transcripts that encode two structural proteins (VP1 and VP2) and three nonstructural proteins (NS1, 7.5-kDa protein, and 11-kDa protein). Splicing at the second 5' donor site (D2 site) of the B19V pre-mRNA is essential for the expression of VP2 and the 11-kDa protein. We previously identified that cis -acting intronic splicing enhancer 2 (ISE2) that lies immediately after the D2 site facilitates the recognition of the D2 donor for its efficient splicing. In this study, we report that ISE2 is critical for the expression of the 11-kDa viral nonstructural protein. We found that ISE2 harbors a consensus RNA binding motif protein 38 (RBM38) binding sequence, 5'-UGUGUG-3'. RBM38 is expressed during the middle stage of erythropoiesis. We first confirmed that RBM38 binds specifically with the ISE2 element in vitro The knockdown of RBM38 significantly decreases the level of spliced mRNA at D2 that encodes the 11-kDa protein but not that of the D2-spliced mRNA that encodes VP2. Importantly, we found that the 11-kDa protein enhances viral DNA replication and virion release. Accordingly, the knockdown of RBM38 decreases virus replication via downregulating 11-kDa protein expression. Taken together, these results suggest that the 11-kDa protein facilitates B19V DNA replication and that RBM38 is an essential host factor for B19V pre-mRNA splicing and for the expression of the 11-kDa protein. IMPORTANCE B19V is a human pathogen that can cause fifth disease, arthropathy, anemia in immunocompromised patients and sickle cell disease patients, myocarditis, and hydrops fetalis in pregnant women. Human erythroid progenitor cells (EPCs) are most susceptible to B19V infection and fully support viral DNA replication. The exclusive tropism of B19V for erythroid-lineage cells is dependent not only on the expression of viral

  5. CACDA JIFFY III War Game. Volume V. Programmer’s Manual.

    DTIC Science & Technology

    1980-10-01

    60 ONAT1,OLTE-ETER SRC(ENO TO 0113-- .1 066153 REA24A.L265) ASRtc flant54 CALL aPt N(IFIT93L1-O 5060155 1265 PORN *?AM180015 IF1ASRC*EO.3HEND) 60 TO 16...POIN-/9799,ITE4 * iLOST") 12699r IF(IRUMe.Nl.tlPSIN7 c9604X9ET’ZLl. 2273 13 990 PoRn .*TI" .?X.!2,5W*F6#D 12T20 IFLAG2ut Z 33 -UIll-Offf THUE k COUTPUT...A344b3299999. sfl IFIIHI’l&.NE.9q99@.3G0 ’?O 160 IZ TNH S CLNP!~CORC NOT FOUND- dOG IT TO MISTORY FILE 35C67: co 150 1.390 9O £1411 3.. ;5C69: 150 C

  6. 1073 K (800 °C) Isothermal Section of the Co-Al-V System

    NASA Astrophysics Data System (ADS)

    Liao, Guangjing; Yin, Fucheng; Liu, Ye; Zhao, Manxiu

    2017-08-01

    The isothermal section of the Co-Al-V ternary system at 1073 K (800 °C) has been determined by means of X-ray diffraction and scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. Thirteen three-phase regions have been confirmed experimentally. A new ternary compound named `T' phase (Al2CoV) is found in this study which possesses a face-centered cubic (fcc) structure with a lattice parameter of 11.7224 Å. The T phase can be in equilibrium with Al3V, Al8V5, α-V, Al5Co2, and AlCo. The maximum solubility of Al in Co3V, σ-CoV, and CoV3 is 5.6, 6.3, and 4 at. pct, respectively. The maximum solubility of Co in Al3V, Al8V5, and α-V is 1.1, 2.5, and 24.9 at. pct, respectively. The maximum solubility of V in Al9Co2, Al13Co4, Al3Co, Al5Co2, AlCo, and α-Co is 0.3, 0.2, 0.1, 2.1, 35.0, and 16.4 at. pct, respectively.

  7. 11 CFR 9032.11 - State.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false State. 9032.11 Section 9032.11 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: PRESIDENTIAL PRIMARY MATCHING FUND DEFINITIONS § 9032.11 State. State means each State of the United States, Puerto Rico, American...

  8. 10 CFR 11.11 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false General requirements. 11.11 Section 11.11 Energy NUCLEAR... SPECIAL NUCLEAR MATERIAL Requirements for Special Nuclear Material Access Authorization § 11.11 General..., formula quantities of special nuclear material (as defined in part 73 of this chapter) subject to the...

  9. 10 CFR 11.11 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false General requirements. 11.11 Section 11.11 Energy NUCLEAR... SPECIAL NUCLEAR MATERIAL Requirements for Special Nuclear Material Access Authorization § 11.11 General..., formula quantities of special nuclear material (as defined in part 73 of this chapter) subject to the...

  10. 10 CFR 11.11 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false General requirements. 11.11 Section 11.11 Energy NUCLEAR... SPECIAL NUCLEAR MATERIAL Requirements for Special Nuclear Material Access Authorization § 11.11 General..., formula quantities of special nuclear material (as defined in part 73 of this chapter) subject to the...

  11. 10 CFR 11.11 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false General requirements. 11.11 Section 11.11 Energy NUCLEAR... SPECIAL NUCLEAR MATERIAL Requirements for Special Nuclear Material Access Authorization § 11.11 General..., formula quantities of special nuclear material (as defined in part 73 of this chapter) subject to the...

  12. 10 CFR 11.11 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false General requirements. 11.11 Section 11.11 Energy NUCLEAR... SPECIAL NUCLEAR MATERIAL Requirements for Special Nuclear Material Access Authorization § 11.11 General..., formula quantities of special nuclear material (as defined in part 73 of this chapter) subject to the...

  13. A technician works adjacent to the Apollo 11 spacecraft atop the white room.

    NASA Technical Reports Server (NTRS)

    1969-01-01

    A technician can be seen working atop the white room across from the escape tower of the Apollo 11 spacecraft a few days prior to the launch of the Saturn V moon rocket. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams

  14. Electroproduction of Eta Mesons in the S11(1535) Resonance Region at High Momentum Transfer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dalton, Mark; Adams, Gary; Ahmidouch, Abdellah

    2009-01-01

    The differential cross-section for the process p(e,e'p)eta has been measured at Q2 ~ 5.7 and 7.0 (GeV/c)2 for centre-of-mass energies from threshold to 1.8 GeV, encompassing the S11(1535) resonance, which dominates the channel. This is the highest momentum transfer measurement of this exclusive process to date. The helicity-conserving transition amplitude A_1/2, for the production of the S11(1535) resonance, is extracted from the data. This quantity appears to begin scaling as 1/Q3, a predicted signal of the dominance of perturbative QCD, at Q2 ~ 5 (GeV/c)2.

  15. Separation of V(V)-4-(2-pyridylazo)resorcinolato complex from a large excess reagent using an ODS cartridge for high-performance liquid chromatography.

    PubMed

    Takahashi, Toru; Kaneko, Emiko; Yotsuyanagi, Takao

    2006-12-01

    A selective off-line preconcentration technique for the V(V) complex with 4-(2-pyridylazo)resorcinol has been developed and successfully applied to the determination of V(V) in an air-borne sample. The target complex was separated from excess reagent using an ODS cartridge and water as the eluent. The complex was then concentrated on another ODS cartridge using tetrabutylammonium bromide and eluted with methanol; the eluate was applied to a one-drop concentration/HPLC. A detection limit as low as (6.05 +/- 0.82)x 10(-11) M (5 ppt) was achieved.

  16. Subnanometer Ga2O3 tunnelling layer by atomic layer deposition to achieve 1.1 V open-circuit potential in dye-sensitized solar cells.

    PubMed

    Chandiran, Aravind Kumar; Tetreault, Nicolas; Humphry-Baker, Robin; Kessler, Florian; Baranoff, Etienne; Yi, Chenyi; Nazeeruddin, Mohammad Khaja; Grätzel, Michael

    2012-08-08

    Herein, we present the first use of a gallium oxide tunnelling layer to significantly reduce electron recombination in dye-sensitized solar cells (DSC). The subnanometer coating is achieved using atomic layer deposition (ALD) and leading to a new DSC record open-circuit potential of 1.1 V with state-of-the-art organic D-π-A sensitizer and cobalt redox mediator. After ALD of only a few angstroms of Ga(2)O(3), the electron back reaction is reduced by more than an order of magnitude, while charge collection efficiency and fill factor are increased by 30% and 15%, respectively. The photogenerated exciton separation processes of electron injection into the TiO(2) conduction band and the hole injection into the electrolyte are characterized in detail.

  17. Characterization and surface treatment effects on topography of a glass-infiltrated alumina/zirconia-reinforced ceramic.

    PubMed

    Della Bona, Alvaro; Donassollo, Tiago A; Demarco, Flávio F; Barrett, Allyson A; Mecholsky, John J

    2007-06-01

    Characterize the microstructure, composition and some physical properties of a glass-infiltrated alumina/zirconia-reinforced ceramic (IZ) and the effect of surface treatment on topography. IZ ceramic specimens were fabricated according to ISO6872 instructions and polished through 1 microm alumina abrasive. Quantitative and qualitative analyses were performed using scanning electron microscopy (SEM), backscattered imaging (BSI), electron dispersive spectroscopy (EDS) and stereology. The elastic modulus (E) and Poisson's ratio (nu) were determined using ultrasonic waves, and the density (rho) using a helium pycnometer. The following ceramic surface treatments were used: AP-as-polished; HF-etching with 9.5% hydrofluoric acid for 90 s; SB-sandblasting with 25 microm aluminum oxide particles for 15s and SC-blasting with 30 microm aluminum oxide particles modified by silica (silica coating) for 15s. An optical profilometer was used to examine the surface roughness (Ra) and SEM-EDS were used to measure the amount of silica after all treatments. The IZ mean property values were as follows: rho=4.45+/-0.01 g/cm(3); nu=0.26 and E=245 GPa. Mean Ra values were similar for AP- and HF-treated IZ but significantly increased after either SC or SB treatment (pIZ ceramic. Treating IZ with either SB or SC produced greater Ra values and the SC showed a significant increase in the surface concentration of silica, which may enhance bonding to resin via silane coupling.

  18. 42 CFR 54a.11 - Effect on State and local funds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Effect on State and local funds. 54a.11 Section 54a... DISCRETIONARY FUNDING UNDER TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, et seq., FOR SUBSTANCE ABUSE PREVENTION AND TREATMENT SERVICES § 54a.11 Effect on State and local funds. If a State or local...

  19. 42 CFR 54a.11 - Effect on State and local funds.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Effect on State and local funds. 54a.11 Section 54a... DISCRETIONARY FUNDING UNDER TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, ET SEQ., FOR SUBSTANCE ABUSE PREVENTION AND TREATMENT SERVICES § 54a.11 Effect on State and local funds. If a State or local...

  20. 42 CFR 54a.11 - Effect on State and local funds.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Effect on State and local funds. 54a.11 Section 54a... DISCRETIONARY FUNDING UNDER TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, et seq., FOR SUBSTANCE ABUSE PREVENTION AND TREATMENT SERVICES § 54a.11 Effect on State and local funds. If a State or local...

  1. 42 CFR 54a.11 - Effect on State and local funds.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Effect on State and local funds. 54a.11 Section 54a... DISCRETIONARY FUNDING UNDER TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, ET SEQ., FOR SUBSTANCE ABUSE PREVENTION AND TREATMENT SERVICES § 54a.11 Effect on State and local funds. If a State or local...

  2. 42 CFR 54a.11 - Effect on State and local funds.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Effect on State and local funds. 54a.11 Section 54a... DISCRETIONARY FUNDING UNDER TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, ET SEQ., FOR SUBSTANCE ABUSE PREVENTION AND TREATMENT SERVICES § 54a.11 Effect on State and local funds. If a State or local...

  3. (d ,n ) proton-transfer reactions on 9Be, 11B, 13C, N,1514, and 19F and spectroscopic factors at Ed=16 MeV

    NASA Astrophysics Data System (ADS)

    Febbraro, M.; Becchetti, F. D.; Torres-Isea, R. O.; Riggins, J.; Lawrence, C. C.; Kolata, J. J.; Howard, A. M.

    2017-08-01

    The (d ,n ) reaction has been studied with targets of 9Be, 11B, 13C, N,1514, and 19F at Ed=16 MeV using a deuterated liquid-scintillator array. Advanced spectral unfolding techniques with accurately measured scintillator response functions were employed to extract neutron energy spectra without the need for long-path neutron time-of-flight. An analysis of the proton-transfer data at forward angles to the ground states of the final nuclei, using finite-range distorted-wave Born approximation analysis with common bound-state, global, and local optical-model parameter sets, yields a set of self-consistent spectroscopic factors. These are compared with the results of several previous time-of-flight measurements, most done many years ago for individual nuclei at lower energy and often analyzed using zero-range transfer codes. In contrast to some of the earlier published data, our data generally compare well with simple shell-model predictions, with little evidence for uniform quenching (reduction from shell-model values) that has previously been reported from analysis of nucleon knock-out reactions. Data for low-lying excited states in 14N from 13C(d ,n ) also is analyzed and spectroscopic information relevant to nuclear astrophysics obtained. A preliminary study of the radioactive ion beam induced reaction 7Be(d ,n ) , E (7Be)=30 MeV was carried out and indicates further improvements are needed for such measurements, which require detection of neutrons with En<2 MeV .

  4. Involvement of MoVMA11, a Putative Vacuolar ATPase c’ Subunit, in Vacuolar Acidification and Infection-Related Morphogenesis of Magnaporthe oryzae

    PubMed Central

    Chen, Guoqing; Liu, Xiaohong; Zhang, Lilin; Cao, Huijuan; Lu, Jianping; Lin, Fucheng

    2013-01-01

    Many functions of vacuole depend on the activity of vacuolar ATPase which is essential to maintain an acidic lumen and create the driving forces for massive fluxes of ions and metabolites through vacuolar membrane. In filamentous fungus Magnaporthe oryzae , subcellular colocalization and quinacrine staining suggested that the V1V0 domains of V-ATPase were fully assembled and the vacuoles were kept acidic during infection-related developments. Targeted gene disruption of MoVMA11 gene, encoding the putative c’ subunit of V-ATPase, impaired vacuolar acidification and mimicked the phenotypes of yeast V-ATPase mutants in the poor colony morphology, abolished asexual and sexual reproductions, selective carbon source utilization, and increased calcium and heavy metals sensitivities, however, not in the typical pH conditional lethality. Strikingly, aerial hyphae of the MoVMA11 null mutant intertwined with each other to form extremely thick filamentous structures. The results also implicated that MoVMA11 was involved in cell wall integrity and appressorium formation. Abundant non-melanized swollen structures and rare, small appressoria without penetration ability were produced at the hyphal tips of the ΔMovma11 mutant on onion epidermal cells. Finally, the MoVMA11 null mutant lost pathogenicity on both intact and wounded host leaves. Overall, our data indicated that MoVMA11, like other fungal VMA genes, is associated with numerous cellular functions and highlighted that V-ATPase is essential for infection-related morphogenesis and pathogenesis in M . oryzae . PMID:23826342

  5. Space Stations.

    DTIC Science & Technology

    1980-04-01

    4 C X 0Z C X - . -0 a m -- L ( U -. W 0 t a - a L 0 r 0 5 U w ( U f i C 0 -a- .. s -an 21.Z IZ W 0 *1 0 0 5 a . - C o ag CL W3 Iz, go, Cc’s "X i -J...50 4- a o r.) LU 0 . A9 0 A (A0 - -VZ % AG 0n W.- C-C- ’-O CL N. L) a D > ) InS r -a 0a C 4 C065 E- 04- 0j cv c I- 0 L U) a -- C GD - - L -z Cd ~J C 1...0 0 -C 041 a OC 0. CW0 McL (n. C/C w. &U - 0. a) O : 0 JC O V EW( W WC -’ - C’. 2 0. L U 0- U 0 10---id - ’D 4)c C(C C’d 0. E- aG do il- W WCD C E L C

  6. Functional mapping of the pelvic floor and sphincter muscles from high-density surface EMG recordings.

    PubMed

    Peng, Yun; He, Jinbao; Khavari, Rose; Boone, Timothy B; Zhang, Yingchun

    2016-11-01

    Knowledge of the innervation of pelvic floor and sphincter muscles is of great importance to understanding the pathophysiology of female pelvic floor dysfunctions. This report presents our high-density intravaginal and intrarectal electromyography (EMG) probes and a comprehensive innervation zone (IZ) imaging technique based on high-density EMG readings to characterize the IZ distribution. Both intravaginal and intrarectal probes are covered with a high-density surface electromyography electrode grid (8 × 8). Surface EMG signals were acquired in ten healthy women performing maximum voluntary contractions of their pelvic floor. EMG decomposition was performed to separate motor-unit action potentials (MUAPs) and then localize their IZs. High-density surface EMG signals were successfully acquired over the vaginal and rectal surfaces. The propagation patterns of muscle activity were clearly visualized for multiple muscle groups of the pelvic floor and anal sphincter. During each contraction, up to 218 and 456 repetitions of motor units were detected by the vaginal and rectal probes, respectively. MUAPs were separated with their IZs identified at various orientations and depths. The proposed probes are capable of providing a comprehensive mapping of IZs of the pelvic floor and sphincter muscles. They can be employed as diagnostic and preventative tools in clinical practices.

  7. Tripal v1.1: a standards-based toolkit for construction of online genetic and genomic databases.

    PubMed

    Sanderson, Lacey-Anne; Ficklin, Stephen P; Cheng, Chun-Huai; Jung, Sook; Feltus, Frank A; Bett, Kirstin E; Main, Dorrie

    2013-01-01

    Tripal is an open-source freely available toolkit for construction of online genomic and genetic databases. It aims to facilitate development of community-driven biological websites by integrating the GMOD Chado database schema with Drupal, a popular website creation and content management software. Tripal provides a suite of tools for interaction with a Chado database and display of content therein. The tools are designed to be generic to support the various ways in which data may be stored in Chado. Previous releases of Tripal have supported organisms, genomic libraries, biological stocks, stock collections and genomic features, their alignments and annotations. Also, Tripal and its extension modules provided loaders for commonly used file formats such as FASTA, GFF, OBO, GAF, BLAST XML, KEGG heir files and InterProScan XML. Default generic templates were provided for common views of biological data, which could be customized using an open Application Programming Interface to change the way data are displayed. Here, we report additional tools and functionality that are part of release v1.1 of Tripal. These include (i) a new bulk loader that allows a site curator to import data stored in a custom tab delimited format; (ii) full support of every Chado table for Drupal Views (a powerful tool allowing site developers to construct novel displays and search pages); (iii) new modules including 'Feature Map', 'Genetic', 'Publication', 'Project', 'Contact' and the 'Natural Diversity' modules. Tutorials, mailing lists, download and set-up instructions, extension modules and other documentation can be found at the Tripal website located at http://tripal.info. DATABASE URL: http://tripal.info/.

  8. Tripal v1.1: a standards-based toolkit for construction of online genetic and genomic databases

    PubMed Central

    Sanderson, Lacey-Anne; Ficklin, Stephen P.; Cheng, Chun-Huai; Jung, Sook; Feltus, Frank A.; Bett, Kirstin E.; Main, Dorrie

    2013-01-01

    Tripal is an open-source freely available toolkit for construction of online genomic and genetic databases. It aims to facilitate development of community-driven biological websites by integrating the GMOD Chado database schema with Drupal, a popular website creation and content management software. Tripal provides a suite of tools for interaction with a Chado database and display of content therein. The tools are designed to be generic to support the various ways in which data may be stored in Chado. Previous releases of Tripal have supported organisms, genomic libraries, biological stocks, stock collections and genomic features, their alignments and annotations. Also, Tripal and its extension modules provided loaders for commonly used file formats such as FASTA, GFF, OBO, GAF, BLAST XML, KEGG heir files and InterProScan XML. Default generic templates were provided for common views of biological data, which could be customized using an open Application Programming Interface to change the way data are displayed. Here, we report additional tools and functionality that are part of release v1.1 of Tripal. These include (i) a new bulk loader that allows a site curator to import data stored in a custom tab delimited format; (ii) full support of every Chado table for Drupal Views (a powerful tool allowing site developers to construct novel displays and search pages); (iii) new modules including ‘Feature Map’, ‘Genetic’, ‘Publication’, ‘Project’, ‘Contact’ and the ‘Natural Diversity’ modules. Tutorials, mailing lists, download and set-up instructions, extension modules and other documentation can be found at the Tripal website located at http://tripal.info. Database URL: http://tripal.info/ PMID:24163125

  9. Electroexcitation of the P33(1232), P11(1440), D13(1520), S11(1535) at Q{sup 2} = 0.4 and 0.65(GeV/c){sup 2}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Inna Aznauryan; Volker Burkert; Hovanes Egiyan

    2004-07-01

    Using two approaches: dispersion relations and isobar model, we have analyzed recent high precision CLAS data on cross sections of {pi}{sup 0}, {pi}{sup +}, and {eta} electroproduction on protons, and the longitudinally polarized electron beam asymmetry for p({rvec e},e{prime}p){pi}{sup 0} and p({rvec e},e{prime}p){pi}{sup +}. The contributions of the resonances P{sub 33}(1232), P{sub 11}(1440), D{sub 13}(1520), S{sub 11}(1535) to {pi} electroproduction and S{sub 11}(1535) to {eta} electroproduction are found. The results obtained in the two approaches are in good agreement with each other. There is also good agreement between amplitudes of the {gamma}* N {yields} S{sub 11}(1535) transition found in {pi}more » and {eta} electroproduction. For the first time accurate results are obtained for the longitudinal amplitudes of the P{sub 11}(1440), D{sub 13}(1520) and S{sub 11}(1535) electroexcitation on protons.« less

  10. Halo-induced large enhancement of soft dipole excitation of 11Li observed via proton inelastic scattering

    NASA Astrophysics Data System (ADS)

    Tanaka, J.; Kanungo, R.; Alcorta, M.; Aoi, N.; Bidaman, H.; Burbadge, C.; Christian, G.; Cruz, S.; Davids, B.; Diaz Varela, A.; Even, J.; Hackman, G.; Harakeh, M. N.; Henderson, J.; Ishimoto, S.; Kaur, S.; Keefe, M.; Krücken, R.; Leach, K. G.; Lighthall, J.; Padilla Rodal, E.; Randhawa, J. S.; Ruotsalainen, P.; Sanetullaev, A.; Smith, J. K.; Workman, O.; Tanihata, I.

    2017-11-01

    Proton inelastic scattering off a neutron halo nucleus, 11Li, has been studied in inverse kinematics at the IRIS facility at TRIUMF. The aim was to establish a soft dipole resonance and to obtain its dipole strength. Using a high quality 66 MeV 11Li beam, a strongly populated excited state in 11Li was observed at Ex = 0.80 ± 0.02 MeV with a width of Γ = 1.15 ± 0.06 MeV. A DWBA (distorted-wave Born approximation) analysis of the measured differential cross section with isoscalar macroscopic form factors leads us to conclude that this observed state is excited in an electric dipole (E1) transition. Under the assumption of isoscalar E1 transitions, the strength is evaluated to be extremely large amounting to 30 ∼ 296 Weisskopf units, exhausting 2.2% ∼ 21% of the isoscalar E1 energy-weighted sum rule (EWSR) value. The large observed strength originates from the halo and is consistent with the simple di-neutron model of 11Li halo.

  11. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the R/V Ronald H. Brown Repeat Hydrography Cruise in the Atlantic Ocean: CLIVAR CO2 Section A16S_2005 (11 January - 24 February, 2005)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kozyr, Alex

    This report presents methods, and analytical and quality control procedures for salinity, oxygen, nutrient, inorganic carbon, organic carbon, chlorofluorocarbon (CFC), and bomb 14C system parameters performed during the A16S_2005 cruise, which took place from January 11 to February 24, 2005, aboard research vessel (R/V) Ronald H. Brown under the auspices of the National Oceanic and Atmospheric Administration (NOAA). The R/V Ronald H. Brown departed Punta Arenas, Chile, on January 11, 2005, and ended its cruise in Fortaleza, Brazil, on February 24, 2005. The research conducted was one of a series of repeat hydrography sections jointly funded by NOAA and themore » National Science Foundation as part of the CLIVAR/CO 2/repeat hydrography/tracer program. Samples were taken from 36 depths at 121 stations. The data presented in this report include the analyses of water samples for total inorganic carbon (TCO 2), fugacity of CO 2 (fCO 2), total alkalinity (TALK), pH, dissolved organic carbon (DOC), CFC, 14C, hydrographic, and other chemical measurements. The R/V Ronald H. Brown A16S_2005 data set is available free of charge as a numeric data package (NDP) from the Carbon Dioxide Information Analysis Center (CDIAC). The NDP consists of the oceanographic data files and this printed documentation, which describes the procedures and methods used to obtain the data.« less

  12. A hole inversion layer at the BiVO4/Bi4V2O11 interface produces a high tunable photovoltage for water splitting

    NASA Astrophysics Data System (ADS)

    Dos Santos, Wayler S.; Rodriguez, Mariandry; Afonso, André S.; Mesquita, João P.; Nascimento, Lucas L.; Patrocínio, Antônio O. T.; Silva, Adilson C.; Oliveira, Luiz C. A.; Fabris, José D.; Pereira, Márcio C.

    2016-08-01

    The conversion of solar energy into hydrogen fuel by splitting water into photoelectrochemical cells (PEC) is an appealing strategy to store energy and minimize the extensive use of fossil fuels. The key requirement for efficient water splitting is producing a large band bending (photovoltage) at the semiconductor to improve the separation of the photogenerated charge carriers. Therefore, an attractive method consists in creating internal electrical fields inside the PEC to render more favorable band bending for water splitting. Coupling ferroelectric materials exhibiting spontaneous polarization with visible light photoactive semiconductors can be a likely approach to getting higher photovoltage outputs. The spontaneous electric polarization tends to promote the desirable separation of photogenerated electron- hole pairs and can produce photovoltages higher than that obtained from a conventional p-n heterojunction. Herein, we demonstrate that a hole inversion layer induced by a ferroelectric Bi4V2O11 perovskite at the n-type BiVO4 interface creates a virtual p-n junction with high photovoltage, which is suitable for water splitting. The photovoltage output can be boosted by changing the polarization by doping the ferroelectric material with tungsten in order to produce the relatively large photovoltage of 1.39 V, decreasing the surface recombination and enhancing the photocurrent as much as 180%.

  13. A hole inversion layer at the BiVO4/Bi4V2O11 interface produces a high tunable photovoltage for water splitting

    PubMed Central

    dos Santos, Wayler S.; Rodriguez, Mariandry; Afonso, André S.; Mesquita, João P.; Nascimento, Lucas L.; Patrocínio, Antônio O. T.; Silva, Adilson C.; Oliveira, Luiz C. A.; Fabris, José D.; Pereira, Márcio C.

    2016-01-01

    The conversion of solar energy into hydrogen fuel by splitting water into photoelectrochemical cells (PEC) is an appealing strategy to store energy and minimize the extensive use of fossil fuels. The key requirement for efficient water splitting is producing a large band bending (photovoltage) at the semiconductor to improve the separation of the photogenerated charge carriers. Therefore, an attractive method consists in creating internal electrical fields inside the PEC to render more favorable band bending for water splitting. Coupling ferroelectric materials exhibiting spontaneous polarization with visible light photoactive semiconductors can be a likely approach to getting higher photovoltage outputs. The spontaneous electric polarization tends to promote the desirable separation of photogenerated electron- hole pairs and can produce photovoltages higher than that obtained from a conventional p-n heterojunction. Herein, we demonstrate that a hole inversion layer induced by a ferroelectric Bi4V2O11 perovskite at the n-type BiVO4 interface creates a virtual p-n junction with high photovoltage, which is suitable for water splitting. The photovoltage output can be boosted by changing the polarization by doping the ferroelectric material with tungsten in order to produce the relatively large photovoltage of 1.39 V, decreasing the surface recombination and enhancing the photocurrent as much as 180%. PMID:27503274

  14. Study of 11Li+p elastic scattering using BHF formalism with three body force

    NASA Astrophysics Data System (ADS)

    Sharma, Manjari; Haider, W.

    2018-04-01

    In the present work we have analyzed the elastic scattering data of 11Li + p at 62, 68.4 and 75 MeV/nucleon, using the microscopic optical potential calculated within the framework of Brueckner-Hartree-Fock formalism (BHF). The calculation uses Argonne v18 and Urbana v14 inter-nucleon potentials and the Urbana IX (UVIX) model of three body force. The required nucleon-density distributions for 11Li are obtained using the semi-phenomenological model for nuclear density distributions. The optical potential has been obtained by folding the g-matrices as calculated in BHF (with and without three body forces) over the nucleon density distributions. We have used the exact method for calculating both the direct and the exchange parts of the spin-orbit potential. Our results reveal that the spin-orbit potential significantly contributes to 11Li+p elastic scattering at all three incident energies. Further, the calculated spin-orbit potential in BHF is much smaller and more diffused as compared with the phenomenological spin-orbit potential. The analysis reveals that the calculated microscopic optical potentials, with and without three body force using BHF approach with phenomenological form of density distribution, provides satisfactory agreement with the elastic scattering data for 11Li+p.

  15. Task Organizing for Urban Combat

    DTIC Science & Technology

    1978-06-09

    muber o" le e. artillery and armor units for a given infantry forco. S S 4 * iii ŜIs PAGE IS BEST QUALtTY PRAJTt-NrjL ~ ~ k -~i ~U ~IVjR~ DDC - UTZ1LE Oa...BIBLIOGRA.WPY .. .. .............. . . . . 107 tV 9I1S PAGE IS BEST QUALITY IUACTICABL" T" Cut x k uwjilH4. :V WGO IS T OF TA dJ!Z; Vable a I. Soviet...iz u1ece’d i.n " cal brigade sel,÷,or in orntral Germany. A representative Qwator at- defenaive front of approximately twnty-fiv.r k - e. tce • sector

  16. Large Starspot Groups on HAT-P-11 in Activity Cycle 1

    NASA Astrophysics Data System (ADS)

    Morris, Brett M.; Hawley, Suzanne L.; Hebb, Leslie

    2018-02-01

    HAT-P-11 is a planet-hosting K4V star in the Kepler field, with an activity cycle that bear similarities to the Sun's. The chromospheric activity of HAT-P-11 indicates that a new activity cycle is beginning. We report ground-based observations with holographic diffuser photometry to measure the starspots of HAT-P-11 in its second observed magnetic activity cycle (Cycle 1). We find the area coverage of starspots within the transit chord for UTC 2017-10-30 is 14% --- which makes this transit the most spotted HAT-P-11 transit observed to date. We suggest that we are likely observing occultations of large spot groups appearing at the beginning of Cycle 1.

  17. Structural Basis for the Binding of the Neutralizing Antibody, 7D11, to the Poxvirus L1 Protein

    DTIC Science & Technology

    2007-08-01

    pCR- 7D11-vHC and pCR-7D11- vLC , respectively. Crystallization of the complex between L1 and 7D11-Fab VACV L1 protein was expressed and purified as...2005. Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in...D.M., Schmaljohn, C., Schmaljohn, A., 2000. DNA vaccination with vaccinia virus L1R and A33R genes protects mice against a lethal poxvirus challenge

  18. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong talks with a former Apollo team member during an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  19. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong poses for a photograph with fans who attended the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  20. Alloy Design and Development of Cast Cr-W-V Ferritic Steels for Improved High-Temperature Strength for Power Generation Applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klueh, R L; Maziasz, P J; Vitek, J M

    2006-09-23

    Economic and environmental concerns demand that the power-generation industry seek increased efficiency for gas turbines. Higher efficiency requires higher operating temperatures, with the objective temperature for the hottest sections of new systems {approx} 593 C, and increasing to {approx} 650 C. Because of their good thermal properties, Cr-Mo-V cast ferritic steels are currently used for components such as rotors, casings, pipes, etc., but new steels are required for the new operating conditions. The Oak Ridge National Laboratory (ORNL) has developed new wrought Cr-W-V steels with 3-9% Cr, 2-3% W, 0.25% V (compositions are in wt.%), and minor amounts of additionalmore » elements. These steels have the strength and toughness required for turbine applications. Since cast alloys are expected to behave differently from wrought material, work was pursued to develop new cast steels based on the ORNL wrought compositions. Nine casting test blocks with 3, 9, and 11% Cr were obtained. Eight were Cr-W-V-Ta-type steels based on the ORNL wrought steels; the ninth was COST CB2, a 9Cr-Mo-Co-V-Nb cast steel, which was the most promising cast steel developed in a European alloy-development program. The COST CB2 was used as a control to which the new compositions were compared, and this also provided a comparison between Cr-W-V-Ta and Cr-Mo-V-Nb compositions. Heat treatment studies were carried out on the nine castings to determine normalizing-and-tempering treatments. Microstructures were characterized by both optical and transmission electron microscopy (TEM). Tensile, impact, and creep tests were conducted. Test results on the first nine cast steel compositions indicated that properties of the 9Cr-Mo-Co-V-Nb composition of COST CB2 were better than those of the 3Cr-, 9Cr-, and 11Cr-W-V-Ta steels. Analysis of the results of this first iteration using computational thermodynamics raised the question of the effectiveness in cast steels of the Cr-W-V-Ta combination versus the

  1. Liftoff of the Apollo 11 lunar landing mission

    NASA Image and Video Library

    1969-07-16

    S69-39957 (16 July 1969) --- A 70mm Airborne Lightweight Optical Tracking System (ALOTS) took this picture. ALOTS tracking camera mounted on an Air Force EC-135 aircraft flying at about 40,000 feet altitude photographed this event in the early moments of the Apollo 11 launch. The 7.6 million-pound thrust Saturn V (S-1C) first stage boosts the space vehicle to an altitude of 36.3 nautical miles at 50.6 nautical miles downrange in 2 minutes 40.8 seconds. The S-1C stage separates at 2 minutes 41.6 seconds after liftoff. The crew of the Apollo 11 NASA's first lunar landing mission are astronauts Neil A. Armstrong, Michael Collins, and Edwin E. Aldrin Jr. The Apollo 11 launch was at 9:32 a.m. (EDT), July 16, 1969.

  2. Aqueous V(V)-peroxo-amino acid chemistry. Synthesis, structural and spectroscopic characterization of unusual ternary dinuclear tetraperoxo vanadium(V)-glycine complexes.

    PubMed

    Gabriel, C; Kaliva, M; Venetis, J; Baran, P; Rodriguez-Escudero, I; Voyiatzis, G; Zervou, M; Salifoglou, A

    2009-01-19

    Vanadium participation in cellular events entails in-depth comprehension of its soluble and bioavailable forms bearing physiological ligands in aqueous distributions of binary and ternary systems. Poised to understand the ternary V(V)-H(2)O(2)-amino acid interactions relevant to that metal ion's biological role, we have launched synthetic efforts involving the physiological ligands glycine and H(2)O(2). In a pH-specific fashion, V(2)O(5), glycine, and H(2)O(2) reacted and afforded the unusual complexes (H(3)O)(2)[V(2)(O)(2)(mu(2):eta(2):eta(1)-O(2))(2)(eta(2)-O(2))(2)(C(2)H(5)NO(2))] x 5/4 H(2)O (1) and K(2)[V(2)(O)(2)(mu(2):eta(2):eta(1)-O(2))(2)(eta(2)-O(2))(2)(C(2)H(5)NO(2))] x H(2)O (2). 1 crystallizes in the triclinic space group P1, with a = 7.805(4) A, b = 8.134(5) A, c = 12.010(7) A, alpha = 72.298(9) degrees, beta = 72.991(9) degrees, gamma = 64.111(9) degrees, V = 641.9(6) A(3), and Z = 2. 2 crystallizes in the triclinic space group P1, with a = 7.6766(9) A, b = 7.9534(9) A, c = 11.7494(13) A, alpha = 71.768(2) degrees, beta = 73.233(2) degrees, gamma = 65.660(2) degrees, V = 610.15(12) A(3), and Z = 2. Both complexes 1 and 2 were characterized by UV/visible, LC-MS, FT-IR, Raman, NMR spectroscopy, cyclic voltammetry, and X-ray crystallography. The structures of 1 and 2 reveal the presence of unusual ternary dinuclear vanadium-tetraperoxo-glycine complexes containing [(V(V)=O)(O(2))(2)](-) units interacting through long V-O bonds and an effective glycinate bridge. The latter ligand is present in the dianionic assembly as a bidentate moiety spanning both V(V) centers in a zwitterionic form. The collective physicochemical properties of the two ternary species 1 and 2 project the chemical role of the low molecular mass biosubstrate glycine in binding V(V)-diperoxo units, thereby stabilizing a dinuclear V(V)-tetraperoxo dianion. Structural comparisons of the anions in 1 and 2 with other known dinuclear V(V)-tetraperoxo binary anionic species provide insight

  3. High-Q/V Monolithic Diamond Microdisks Fabricated with Quasi-isotropic Etching.

    PubMed

    Khanaliloo, Behzad; Mitchell, Matthew; Hryciw, Aaron C; Barclay, Paul E

    2015-08-12

    Optical microcavities enhance light-matter interactions and are essential for many experiments in solid state quantum optics, optomechanics, and nonlinear optics. Single crystal diamond microcavities are particularly sought after for applications involving diamond quantum emitters, such as nitrogen vacancy centers, and for experiments that benefit from diamond's excellent optical and mechanical properties. Light-matter coupling rates in experiments involving microcavities typically scale with Q/V, where Q and V are the microcavity quality-factor and mode-volume, respectively. Here we demonstrate that microdisk whispering gallery mode cavities with high Q/V can be fabricated directly from bulk single crystal diamond. By using a quasi-isotropic oxygen plasma to etch along diamond crystal planes and undercut passivated diamond structures, we create monolithic diamond microdisks. Fiber taper based measurements show that these devices support TE- and TM-like optical modes with Q > 1.1 × 10(5) and V < 11(λ/n) (3) at a wavelength of 1.5 μm.

  4. SL-7 Extreme Stress Data Collection and Reduction.

    DTIC Science & Technology

    1981-06-01

    w c- o b - C.I I’S ~ ~ ~ ~ I’ ’I, , W0 z II 4i4 00 I.cc ’Sc 4 Z Z IZ O * 3 I 3~ 1 t £ 3 I MS 9 4 V CONTENTS Page I. BACKGROUND 1 II. FUNCTIONAL...SL-7-5, (SSC-257) - S-7 Ins: rumen tati-on Th’ooran Background! and Fesearoh Plan by W. J. Siekierka, R. A. Johnson, and CDR C. S. Loosmore, USCG

  5. Simple and rapid quantification of serotonin transporter binding using [11C]DASB bolus plus constant infusion.

    PubMed

    Gryglewski, G; Rischka, L; Philippe, C; Hahn, A; James, G M; Klebermass, E; Hienert, M; Silberbauer, L; Vanicek, T; Kautzky, A; Berroterán-Infante, N; Nics, L; Traub-Weidinger, T; Mitterhauser, M; Wadsak, W; Hacker, M; Kasper, S; Lanzenberger, R

    2017-04-01

    In-vivo quantification of serotonin transporters (SERT) in human brain has been a mainstay of molecular imaging in the field of neuropsychiatric disorders and helped to explore the underpinnings of several medical conditions, therapeutic and environmental influences. The emergence of PET/MR hybrid systems and the heterogeneity of SERT binding call for the development of efficient methods making the investigation of larger or vulnerable populations with limited scanner time and simultaneous changes in molecular and functional measures possible. We propose [ 11 C]DASB bolus plus constant infusion for these applications and validate it against standard analyses of dynamic PET data. [ 11 C]DASB bolus/infusion optimization was performed on data acquired after [ 11 C]DASB bolus in 8 healthy subjects. Subsequently, 16 subjects underwent one scan using [ 11 C]DASB bolus plus constant infusion with K bol 160-179min and one scan after [ 11 C]DASB bolus for inter-method reliability analysis. Arterial blood sampling and metabolite analysis were performed for all scans. Distribution volumes (V T ) were obtained using Logan plots for bolus scans and ratios between tissue and plasma parent activity for bolus plus infusion scans for different time spans of the scan (V T-70 for 60-70min after start of tracer infusion, V T-90 for 75-90min, V T-120 for 100-120min) in 9 subjects. Omitting blood data, binding potentials (BP ND ) obtained using multilinear reference tissue modeling (MRTM2) and cerebellar gray matter as reference region were compared in 11 subjects. A K bol of 160min was observed to be optimal for rapid equilibration in thalamus and striatum. V T-70 showed good intraclass correlation coefficients (ICCs) of 0.61-0.70 for thalamus, striatal regions and olfactory cortex with bias ≤5.1% compared to bolus scans. ICCs increased to 0.72-0.78 for V T-90 and 0.77-0.93 for V T-120 in these regions. BP ND-90 had negligible bias ≤2.5%, low variability ≤7.9% and ICCs of 0

  6. U.S. EPA, Pesticide Product Label, D.Z.N DIAZINON 50W INSECTICIDE, 04/11/1988

    EPA Pesticide Factsheets

    2011-04-13

    ... i\\ll!Jl'i 1'; I flllt:n.lilt ;:)rl,/ 1 It). I: ;Je,:-n ,Ji 1/.1 f):)!) J~'; ,J\\'~' ;1)·;. j')r-:;ldrd (>11 <)[ ,~ J.l1';. ;\\I;,"T l'lT t '/1)" ()II :"'t l()(j '11: ()f 'vI,lt ··r. j , \\j , -10- ...

  7. 11. Photocopy of a drawing (original in the Collection of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of a drawing (original in the Collection of the PL&V, Shelf 128, Drawing 1795) SKETCH OF PAWTUCKET DAM (HISTORIC DEVELOPMENT PLAN AND SECTIONS) MARCH 1923 - Lowell Canal System, Pawtucket Dam, Merrimack River,above Pawtucket Falls, Lowell, Middlesex County, MA

  8. Coherent Raman Spectra of the nu(1) Mode of 10BF3 and 11BF3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kirkpatrick, Robynne; Masiello, Tony; Weber, Alfons

    2006-05-01

    High resolution (0.001cm-1) coherent anti-Stokes Raman spectroscopy (CARS) was used to directly examine the v1 symmetric stretching mode of the planar symmetric D3h molecules 10BF3 and 11BF3. Simulations of the spectra were done using v1 rovibrational parameters deduced from published infrared hot-band and difference-band studies and the close similarity to the observed CARS spectra confirms the validity of the infrared constants. No significant perturbations by Fermi resonance or Coriolis interactions with nearby states are observed, in marked contrast to the case of sulfur trioxide, a similar D3h molecule recently studied. In the harmonic approximation, the 10BF3 and 11BF3 v1 Q-more » branches would be identical since the isotopic substitution is at the center of mass but, interestingly, the v1 stretching frequency for 11BF3 is found to be 0.198 cm-1 higher than for the lighter 10BF3 isotopomer. This counterintuitive result is reproduced almost exactly (0.200 cm -1) by ab initio calculations (B3LYP/cc-pVTZ) that included evaluation of cubic and quartic forced constants and xij anharmonicity constants. The ab initio computations also predict to within 1% the ?B, ?C changes in the rotational constants in going from the ground state to the v1=1 vibrational level. The results illustrate nicely the complementary interplay of modern infrared, Raman, and ab initio methods in obtaining and analyzing rovibrational spectra.« less

  9. Dollar Summary of Federal Supply Classification and Service Category by Company. Part 9 (6150-7030)

    DTIC Science & Technology

    1990-01-01

    0If 0 0 I in0 .c a i L w I. w 0 L " IZ IK 1- - 4c 8 - 2w w w 0 c I 4 I V0z z z cc zz 0 0 1 -- I I 8- C- 9- C32m I I 1 0 2 (00 acCa IO I W z 0 hi hi w...4 O go w1. 0 a4 C 0~. 0 0 WE IAJ 0 - 60 a La a im L . C 0 # a 4 a 0 f6 I . *o a W 0P -N V- 04m N .4 C- qr .4 -4 4 qv v (IP 4 N- 94 S .4 . 0I 0. -;i

  10. On the extraction of P 11 resonances from πN data

    DOE PAGES

    Hiroyuki Kamano; Nakamura, Satoshi X.; Lee, Tsung -Shung; ...

    2010-06-22

    With the accuracy of the available P 11 amplitudes of πΔ scattering, we show that two resonance poles near the pi Delta threshold, obtained in several analyses, are stable against large variations of parameters within a dynamical coupled-channels analysis. The number of poles in the 1.5 GeV < W < 2 GeV region could be more than one, depending on how the structure of the single-energy solution of SAID is fitted. Lastly, our results indicate the need of more accurate πN scattering data in the W > 1.6 GeV region for high precision resonance extractions.

  11. Dielectron azimuthal anisotropy at mid-rapidity in Au + Au collisions at s N N = 200 GeV

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adamczyk, L.; Adkins, J. K.; Agakishiev, G.

    We report on the first measurement of the azimuthal anisotropy (v2) of dielectrons (e+e- pairs) at mid-rapidity from √sNN=200 GeV Au + Au collisions with the STAR detector at the Relativistic Heavy Ion Collider (RHIC), presented as a function of transverse momentum (pT) for different invariant-mass regions. In the mass region Mee<1.1 GeV/c2 the dielectron v2 measurements are found to be consistent with expectations from π0,η,ω, and Φ decay contributions. In the mass region 1.1

  12. Recent progress in [11 C]carbon dioxide ([11 C]CO2 ) and [11 C]carbon monoxide ([11 C]CO) chemistry.

    PubMed

    Taddei, Carlotta; Gee, Antony D

    2018-03-01

    [ 11 C]Carbon dioxide ([ 11 C]CO 2 ) and [ 11 C]carbon monoxide ([ 11 C]CO) are 2 attractive precursors for labelling the carbonyl position (C═O) in a vast range of functionalised molecules (eg, ureas, amides, and carboxylic acids). The development of radiosynthetic methods to produce functionalised 11 C-labelled compounds is required to enhance the radiotracers available for positron emission tomography, molecular, and medical imaging applications. Following a brief summary of secondary 11 C-precursor production and uses, the review focuses on recent progress with direct 11 C-carboxylation routes with [ 11 C]CO 2 and 11 C-carbonylation with [ 11 C]CO. Novel approaches to generate [ 11 C]CO using CO-releasing molecules (CO-RMs), such as silacarboxylic acids and disilanes, applied to radiochemistry are described and compared with standard [ 11 C]CO production methods. These innovative [ 11 C]CO synthesis strategies represent efficient and reliable [ 11 C]CO production processes, enabling the widespread use of [ 11 C]CO chemistry within the wider radiochemistry community. Copyright © 2017 John Wiley & Sons, Ltd.

  13. Electroexcitation of the P(11)(1440), D(13)(1520), S(11)(1535), and F(15)(1680) up to 4-(GeV/c)**2 from CLAS data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    I.G. Aznaurian

    2006-06-01

    We present the helicity amplitudes for the electroexcitation of the resonances P_11(1440), D_13(1520), S_11(1535), and F_15(1680) on protons extracted from CLAS-JLab data on the pi, 2pi, and eta electroproduction. The obtained results extend over wide region of Q^2, thus providing strict test for the approaches for the description of the nucleon and nucleon resonances. None of the existing approaches gives satisfactory description of the obtained results.

  14. Intensive Survey at 11-Jd-126, Jo Daviess County, Illinois. Volume 3. Data Sheets.

    DTIC Science & Technology

    1983-07-01

    RECORDER: P. Lurenz, Jr. H NOWO DATE:_ _____ V__Level 2 FEATURE______ DATE: 9/82 COLL#_______ 1 23 45 678919 0111 2 13 Total Sherds Rim temper1 Grt Rim...thickness in millimeters LITHIC INVENTORY - 347 - SITE# 11Jd126 LOT# 80 RECORDER: P. Lurenz, Jr. H_______________ DATE: November, 1982 V_______ FEATURE

  15. Direct modulation of tracheal Cl--channel activity by 5,6- and 11,12-EET.

    PubMed

    Salvail, D; Dumoulin, M; Rousseau, E

    1998-09-01

    Using microelectrode potential measurements, we tested the involvement of Cl- conductances in the hyperpolarization induced by 5,6- and 11,12-epoxyeicosatrienoic acid (EET) in airway smooth muscle (ASM) cells. 5,6-EET and 11,12-EET (0.75 microM) caused -5.4 +/- 1.1- and -3.34 +/- 0.95-mV hyperpolarizations, respectively, of rabbit tracheal cells (from a resting membrane potential of -53.25 +/- 0.44 mV), with significant residual repolarizations remaining after the Ca2+-activated K+ channels had been blocked by 10 nM iberiotoxin. In bilayer reconstitution experiments, we demonstrated that the EETs directly inhibit a Ca2+-insensitive Cl- channel from bovine ASM; 1 microM 5,6-EET and 1.5 microM 11,12-EET lowered the unitary current amplitude by 40 (n = 6 experiments) and 44.7% (n = 4 experiments), respectively. Concentration-dependent decreases in channel open probability were observed, with estimated IC50 values of 0.26 microM for 5,6- and 1.15 microM for 11,12-EET. Furthermore, pharmacomechanical tension measurements showed that both regioisomers induced significant bronchorelaxations in epithelium-denuded ASM strips. These results suggest that 5,6- and 11,12-EET can act in ASM as epithelium-derived hyperpolarizing factors.

  16. Predicted accommodative response from image quality in young eyes fitted with different dual-focus designs.

    PubMed

    Faria-Ribeiro, Miguel; Amorim-de-Sousa, Ana; González-Méijome, José M

    2018-05-01

    To investigate the separated and combined influences of inner zone (IZ) diameter and effective add power of dual-focus contact lenses (CL) in the image quality at distance and near viewing, in a functional accommodating model eye. Computational wave-optics methods were used to define zonal bifocal pupil functions, representing the optic zones of nine dual-focus centre-distance CLs. The dual-focus pupil functions were defined having IZ diameters of 2.10 mm, 3.36 mm and 4.00 mm, with add powers of 1.5 D, 2.0 D and 2.5 D (dioptres), for each design, that resulted in a ratio of 64%/36% between the distance and treatment zone areas, bounded by a 6 mm entrance pupil. A through-focus routine was implemented in MATLAB to simulate the changes in image quality, calculated from the Visual Strehl ratio, as the eye with the dual-focus accommodates, from 0 to -3.00 D target vergences. Accommodative responses were defined as the changes in the defocus coefficient, combined with a change in fourth and sixth order spherical aberration, which produced a peak in image quality at each target vergence. Distance viewing image quality was marginally affected by IZ diameter but not by add power. Near image quality obtained when focussing the image formed by the near optics was only higher by a small amount compared to the other two IZ diameters. The mean ± standard deviation values obtained with the three adds were 0.28 ± 0.02, 0.23 ± 0.02 and 0.22 ± 0.02, for the small, medium and larger IZ diameters, respectively. On the other hand, near image quality predicted by focussing the image formed by the distance optics was considerably lower relatively to the other two IZ diameters. The mean ± standard deviation values obtained with the three adds were 0.15 ± 0.01, 0.38 ± 0.00 and 0.54 ± 0.01, for the small, medium and larger IZ diameters, respectively. During near viewing through dual-focus CLs, image quality depends on the diameter of the most inner zone of the CL, while add power

  17. Fermi Large Area Telescope detection of two very-high-energy ( E > 100 GeV) γ-ray photons from the z = 1.1 blazar PKS 0426–380

    DOE PAGES

    Tanaka, Y. T.; Cheung, C. C.; Inoue, Y.; ...

    2013-10-18

    Here, we report the Fermi Large Area Telescope (LAT) detection of two very-high-energy (VHE, E > 100 GeV) γ-ray photons from the directional vicinity of the distant (redshift, z = 1.1) blazar PKS 0426–380. The null hypothesis that both the 134 and 122 GeV photons originate from unrelated sources can be rejected at the 5.5σ confidence level. We therefore claim that at least one of the two VHE photons is securely associated with PKS 0426–380, making it the most distant VHE emitter known to date. The results are in agreement with recent Fermi-LAT constraints on the extragalactic background light (EBL)more » intensity, which imply a z sime 1 horizon for sime 100 GeV photons. The LAT detection of the two VHE γ-rays coincided roughly with flaring states of the source, although we did not find an exact correspondence between the VHE photon arrival times and the flux maxima at lower γ-ray energies. Modeling the γ-ray continuum of PKS 0426–380 with daily bins revealed a significant spectral hardening around the time of the first VHE event detection (LAT photon index Γ sime 1.4) but on the other hand no pronounced spectral changes near the detection time of the second one. This combination implies a rather complex variability pattern of the source in γ-rays during the flaring epochs. An additional flat component is possibly present above several tens of GeV in the EBL-corrected Fermi-LAT spectrum accumulated over the ~8 month high state.« less

  18. U.S. President Richard Milhous Nixon Watches Apollo 11 Recovery

    NASA Technical Reports Server (NTRS)

    1969-01-01

    U.S. President Richard Milhous Nixon, aboard the U.S.S. Hornet aircraft carrier, used binoculars to watch the Apollo 11 Lunar Mission recovery. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF) for 21 days post mission. The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  19. Charge dynamics of MgO single crystals subjected to KeV electron irradiation

    NASA Astrophysics Data System (ADS)

    Boughariou, A.; Blaise, G.; Braga, D.; Kallel, A.

    2004-04-01

    A scanning electron microscope has been equipped to study the fundamental aspects of charge trapping in insulating materials, by measuring the secondary electron emission (SEE) yield σ with a high precision (a few percent), as a function of energy, electron current density, and dose. The intrinsic secondary electron emission yield σ0 of uncharged MgO single crystals annealed at 1000 °C, 2 h, has been studied at four energies 1.1, 5, 15, and 30 keV on three different crystal orientations (100), (110), and (111). At low energies (1.1 and 5 keV) σ0 depends on the crystalline orientation wheras at high energies (30 keV) no differentiation occurs. It is shown that the value of the second crossover energy E2, for which the intrinsic SEE yield σ0=1, is extremely delicate to measure with precision. It is about 15 keV±500 eV for the (100) orientation, 13.5 keV±500 eV for the (110), and 18.5 keV±500 eV for the (111) one. At low current density J⩽105 pA/cm2, the variation of σ with the injected dose makes possible the observation of a self-regulated regime characterized by a steady value of the SEE yield σst=1. At low energies 1.1 and 5 keV, there is no current density effects in MgO, but at high energies ≈30 keV, apparent current density effects come from a bad collect of secondary electrons, due to very high negative surface potential. At 30 keV energy, an intense erratic electron exoemission was observed on the MgO (110) orientation annealed at 1500 °C. This phenomenon is the result of a disruptive process similar to flashover, which takes place at the surface of the material.

  20. 4 CFR 22.11 - Depositions [Rule 11].

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 4 Accounts 1 2011-01-01 2011-01-01 false Depositions [Rule 11]. 22.11 Section 22.11 Accounts... OFFICE CONTRACT APPEALS BOARD § 22.11 Depositions [Rule 11]. (a) When depositions may be taken. After an... of any person by deposition upon oral examination or written questions, for the purpose of discovery...

  1. 4 CFR 22.11 - Depositions [Rule 11].

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Depositions [Rule 11]. 22.11 Section 22.11 Accounts... OFFICE CONTRACT APPEALS BOARD § 22.11 Depositions [Rule 11]. (a) When depositions may be taken. After an... of any person by deposition upon oral examination or written questions, for the purpose of discovery...

  2. Site-controlled crystalline InN growth from the V-pits of a GaN substrate

    NASA Astrophysics Data System (ADS)

    Kuo, Chien-Ting; Hsu, Lung-Hsing; Lai, Yung-Yu; Cheng, Shan-Yun; Kuo, Hao-Chung; Lin, Chien-Chung; Cheng, Yuh-Jen

    2017-05-01

    A site-controlled crystalline InN growth from the V-pits of a GaN substrate was investigated. The V- pits were fabricated by epitaxial lateral growth of GaN over SiO2 disks patterned on a sapphire substrate. InN crystals were found to preferably grow on the inclined {10-11} crystal planes of the V-pits. A V-pit size of 1 μm or less can provide precise site-controlled InN nucleation at the V-pit bottom, while no InN was grown on the rest of the exposed GaN surfaces. The site-controlled nucleation is attributed to the low surface energy point created by the converging six {10-11} crystal facets at the V-pit bottom. When In source supply is below a certain value, this V-pit bottom is the only location able to aggregate enough active sources to start nucleation, thereby providing site-controlled crystal growth.

  3. National Program for Inspection of Non-Federal Dams. Bowers Dam (NH 00330) (NHWRB Number 165.04) Merrimack River Basin, Nashua, New Hampshire. Phase I Inspection Report.

    DTIC Science & Technology

    1980-05-01

    Upsteamfaceof am t riht ourfootdiaete tub gae a trinn wal ettannSal >41-6 Repairs to Rowors TD im MIar ch 13, 1976 14 .’C Four foot diameter tube gate at Metal...11;7 t 5"- z I o 198 -Z30 7130 169 Z99co Po 3 15 • lIz 55 to 󈧥 o d 1q3 (,570 lozo 590 E3 _Z .Z"’ I 1O L A .Z - :., ____-____ __ L-2eA c -. ,’., 9

  4. Bilateral comparison of 10 V standards between the NSAI - NML (Ireland) and the BIPM, February 2016 (part of the ongoing BIPM key comparison BIPM.EM-K11.b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Power, O.; Stock, M.

    2016-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.b, a comparison of the 10 V voltage reference standards of the BIPM and the National Standards Authority of Ireland - National Metrology Laboratory (NSAI - NML), Dublin, Ireland, was carried out in January and February 2016. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM7 (Z7) and BIPM9 (Z9), were transported by freight to NSAI-NML. At NSAI-NML, the reference standard for DC voltage at the 10 V level consists of a group of characterized Zener diode-based electronic voltage standards. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the group standard. At the BIPM the travelling standards were calibrated, before and after the measurements at NSAI-NML, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned to DC voltage standards by NSAI - NML, at the level of 10 V, at NSAI - NML, UNML, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of the 31 of January 2016. UNML - UBIPM = + 0.22 μV uc = 1.35 μV , at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NSAI-NML, based on KJ-90, and the uncertainty related to the comparison. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  5. Bilateral Comparison of 10 V Standards between the NSAI - NML (Ireland) and the BIPM, March 2015 (part of the ongoing BIPM key comparison BIPM.EM-K11.b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Stock, M.; Power, O.

    2015-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.b, a comparison of the 10 V voltage reference standards of the BIPM and the National Standards Authority of Ireland - National Metrology Laboratory (NSAI - NML), Dublin, Ireland, was carried out in February and March 2015. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM6 (Z6) and BIPMC (ZC), were transported by freight to NSAI-NML. At NSAI-NML, the reference standard for DC voltage at the 10 V level consists of a group of characterized Zener diode-based electronic voltage standards. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the group standard. At the BIPM the travelling standards were calibrated, before and after the measurements at NSAI-NML, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final resultof the comparison is presented as the difference between the values assigned to DC voltage standards by NSAI - NML, at the level of 10 V,at NSAI - NML, UNML, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 24 February 2015. UNML - UBIPM = - 0.82 mV; uc = 1.35 mV , at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NSAI-NML, based on KJ-90, and the uncertainty related to the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  6. V405 ANDROMEDA REVISITED

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ribeiro, T.; Baptista, R.; Kafka, S.

    We present a multi-epoch time-resolved high-resolution optical spectroscopy study of the short-period (P{sub orb} = 11.2 hr) eclipsing M0V+M5V RS CVn binary V405 Andromeda. By means of indirect imaging techniques, namely Doppler imaging, we study the surface activity features of the M0V component of the system. A modified version of a Doppler imaging code, which takes into account the tidal distortion of the surface of the star, is applied to the multi-epoch data set in order to provide indirect images of the stellar surface. The multi-epoch surface brightness distributions show a low intensity 'belt' of spots at latitudes {+-}40{sup 0}more » and a noticeable absence of high latitude features or polar spots on the primary star of V405 Andromeda. They also reveal slow evolution of the spot distribution over {approx}4 yr. An entropy landscape procedure is used in order to find the set of binary parameters that lead to the smoothest surface brightness distributions. As a result, we find M{sub 1} = 0.51 {+-} 0.03 M{sub sun}, M{sub 2} = 0.21 {+-} 0.01 M{sub sun}, R{sub 1} = 0.71 {+-} 0.01 R{sub sun}, and an inclination i = 65{sup 0} {+-} 1{sup 0}. The resulting systemic velocity is distinct for different epochs, raising the possibility of the existence of a third body in the system.« less

  7. Respone to March 11, 2001 New York Public Interest Research Group, Inc. Comments on New York's Title V Program

    EPA Pesticide Factsheets

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  8. Evidence of Soft Dipole Resonance in Li 11 with Isoscalar Character

    NASA Astrophysics Data System (ADS)

    Kanungo, R.; Sanetullaev, A.; Tanaka, J.; Ishimoto, S.; Hagen, G.; Myo, T.; Suzuki, T.; Andreoiu, C.; Bender, P.; Chen, A. A.; Davids, B.; Fallis, J.; Fortin, J. P.; Galinski, N.; Gallant, A. T.; Garrett, P. E.; Hackman, G.; Hadinia, B.; Jansen, G.; Keefe, M.; Krücken, R.; Lighthall, J.; McNeice, E.; Miller, D.; Otsuka, T.; Purcell, J.; Randhawa, J. S.; Roger, T.; Rojas, A.; Savajols, H.; Shotter, A.; Tanihata, I.; Thompson, I. J.; Unsworth, C.; Voss, P.; Wang, Z.

    2015-05-01

    The first conclusive evidence of a dipole resonance in Li 11 having isoscalar character observed from inelastic scattering with a novel solid deuteron target is reported. The experiment was performed at the newly commissioned IRIS facility at TRIUMF. The results show a resonance peak at an excitation energy of 1.03 ±0.03 MeV with a width of 0.51 ±0.11 MeV (FWHM). The angular distribution is consistent with a dipole excitation in the distorted-wave Born approximation framework. The observed resonance energy together with shell model calculations show the first signature that the monopole tensor interaction is important in Li 11 . The first ab initio calculations in the coupled cluster framework are also presented.

  9. Flexural strength and failure modes of layered ceramic structures.

    PubMed

    Borba, Márcia; de Araújo, Maico D; de Lima, Erick; Yoshimura, Humberto N; Cesar, Paulo F; Griggs, Jason A; Della Bona, Alvaro

    2011-12-01

    To evaluate the effect of the specimen design on the flexural strength (σ(f)) and failure mode of ceramic structures, testing the hypothesis that the ceramic material under tension controls the mechanical performance of the structure. Three ceramics used as framework materials for fixed partial dentures (YZ--Vita In-Ceram YZ; IZ--Vita In-Ceram Zirconia; AL--Vita In-Ceram AL) and two veneering porcelains (VM7 and VM9) were studied. Bar-shaped specimens were produced in three different designs (n=10): monolithic, two layers (porcelain-framework) and three layers (TRI) (porcelain-framework-porcelain). Specimens were tested for three-point flexural strength at 1MPa/s in 37°C artificial saliva. For bi-layered design, the specimens were tested in both conditions: with porcelain (PT) or framework ceramic (FT) layer under tension. Fracture surfaces were analyzed using stereomicroscope and scanning electron microscopy (SEM). Young's modulus (E) and Poisson's ratio (ν) were determined using ultrasonic pulse-echo method. Results were statistically analyzed by Kruskal-Wallis and Student-Newman-Keuls tests. Except for VM7 and VM9, significant differences were observed for E values among the materials. YZ showed the highest ν value followed by IZ and AL. YZ presented the highest σ(f). There was no statistical difference in the σ(f) value between IZ and IZ-FT and between AL and AL-FT. σ(f) values for YZ-PT, IZ-PT, IZ-TRI, AL-PT, AL-TRI were similar to the results obtained for VM7 and VM9. Two types of fracture mode were identified: total and partial failure. The mechanical performance of the specimens was determined by the material under tension during testing, confirming the study hypothesis. Copyright © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  10. XMM-Newton X-ray spectra of V407 Lup (Nova Lup 2016)

    NASA Astrophysics Data System (ADS)

    Ness, Jan-Uwe; Starrfield, Sumner; Woodward, Chick E.; Kuin, Paul; Page, Kim; Beardmore, Andy; Osborne, Julian; Sala, Gloria; Hernanz, Margarita; Orio, Marina; Williams, Bob

    2017-09-01

    Nova Lup 2016 (V407 Lup) was observed by XMM-Newton from 11 March 2017, 11:45 to 17:08 UT, 168 days after outburst (ATel #9538) with an exposure duration of 23,000 s. The EPIC pn was operated in Timing Mode with Medium filter.

  11. Controlling alpha tracks registration in Makrofol DE 1-1 detector

    NASA Astrophysics Data System (ADS)

    Hassan, N. M.; Hanafy, M. S.; Naguib, A.; El-Saftawy, A. A.

    2017-09-01

    Makrofol DE 1-1 is a recent type of solid state nuclear track detectors could be used to measure radon concentration in the environment throughout the detection of α-particles emitted from radon decay. Thus, studying the physical parameters that control the formation of alpha tracks is vital for environmental radiation protection. Makrofol DE 1-1 polycarbonate detector was irradiated by α-particles of energies varied from 2 to 5 MeV emitted from the 241Am source of α-particle energy of 5.5 MeV. Then, the detector was etched in an optimum etching solution of mixed ethyl alcohol in KOH aqueous solution of (85% (Vol.) of 6 M KOH + 15% (Vol.) C2H5OH) at 50 °C for 3 h. Afterward, the bulk etch rate, etching sensitivity, and the registration efficiency of the detector, which control the tracks registration, were measured. The bulk etch rate of Makrofol detector was found to be 3.71 ± 0.71 μm h-1. The etching sensitivity and the detector registration efficiency were decreased exponentially with α-particles' energies following Bragg curve. A precise registration of α-particle was presented in this study. Therefore, Makrofol DE 1-1 can be applied as a radiation dosimeter as well as radon and thoron monitors.

  12. Tris-(hydroxyamino)triazines: high-affinity chelating tridentate O,N,O-hydroxylamine ligand for the cis-V(V)O2(+) cation.

    PubMed

    Nikolakis, Vladimiros A; Exarchou, Vassiliki; Jakusch, Tamás; Woolins, J Derek; Slawin, Alexandra M Z; Kiss, Tamás; Kabanos, Themistoklis A

    2010-10-14

    The treatment of the trichloro-1,3,5-triazine with N-methylhydroxylamine hydrochloride results in the replacement of the three chlorine atoms of the triazine ring with the function -N(OH)CH(3) yielding the symmetrical tris-(hydroxyamino)triazine ligand H(3)trihyat. Reaction of the ligand H(3)trihyat with NaV(V)O(3) in aqueous solution followed by addition of Ph(4)PCl gave the mononuclear vanadium(V) compound Ph(4)P[V(V)O(2)(Htrihyat)] (1). The structure of compound 1 was determined by X-ray crystallography and indicates that this compound has a distorted square-pyramidal arrangement around vanadium. The ligand Htrihyat(2-) is bonded to vanadium atom in a tridentate fashion at the triazine ring nitrogen atom and the two deprotonated hydroxylamido oxygen atoms. The high electron density of the triazine ring nitrogen atoms, which results from the resonative contribution of electrons of exocyclic nitrogen atoms, leads to a very strong V-N bond. The cis-[V(V)O(2)(Htrihyat)](-) species exhibits high hydrolytic stability in aqueous solution over a wide pH range, 2.5-11.5, as was evidenced by potentiometry.

  13. Effects of trimethoprim-sulfadiazine and detomidine on the function of equine Kv 11.1 channels in a two-electrode voltage-clamp (TEVC) oocyte model.

    PubMed

    Trachsel, D S; Tejada, M A; Groesfjeld Christensen, V; Pedersen, P J; Kanters, J K; Buhl, R; Calloe, K; Klaerke, D A

    2018-03-22

    The long QT syndrome (LQTS) is a channelopathy that can lead to severe arrhythmia and sudden cardiac death. Pharmacologically induced LQTS is caused by interaction between drugs and potassium channels, especially the K v 11.1 channel. Due to such interactions, numerous drugs have been withdrawn from the market or are administered with precautions in human medicine. However, some compounds, such as trimethoprim-sulfonamide combinations are still widely used in veterinarian medicine. Therefore, we investigate the effect of trimethoprim-sulfadiazine (TMS), trimethoprim, sulfadiazine, and detomidine on equine-specific K v 11.1 channels. K v 11.1 channels cloned from equine hearts were heterologously expressed in Xenopus laevis oocytes, and whole cell currents were measured by two-electrode voltage-clamp before and after drug application. TMS blocked equine K v 11.1 current with an IC 50 of 3.74 mm (95% CI: 2.95-4.73 mm) and affected the kinetics of activation and inactivation. Similar was found for trimethoprim but not for sulfadiazine, suggesting the effect is due to trimethoprim. Detomidine did not affect equine K v 11.1 current. Thus, equine K v 11.1 channels are also susceptible to pharmacological block, indicating that some drugs may have the potential to affect repolarization in horse. However, in vivo studies are needed to assess the potential risk of these drugs to induce equine LQTS. © 2018 The Authors. Journal of Veterinary Pharmacology and Therapeutics Published by John Wiley & Sons Ltd.

  14. 10,11 B(α,n) 13 , 14N cross section measurements

    NASA Astrophysics Data System (ADS)

    Liu, Qian; Michael, Febbraro; Deboer, Richard; Michael, Wiescher

    2017-09-01

    10,11 B(α,n) 13 , 14N have been identified as possible background sources for underground experiments at low Eα energy. These reactions have been studied at University of Notre Dame's Nuclear Science Laboratory using Santa Anna 5 MV accelerator. 11B(α,n)14N was measured with a 3He counter, and a good R-matrix fit was obtained, which shows our data in agreement with other published data. Measurement of 10B(α,n)13N was performed down to Eα = 0.57 MeV, with two deuterated liquid scintillators, EJ315 and EJ301D, and with the help of unfolding technique, neutron energy information can be extracted. EJ301D is a newly-developed neutron detector, with better pulse shape discrimination, and has been used to do angular distribution measurements. Additionally, the (α ,α1 γ) and (n , pγ) channels have been monitored independently by observation of 718keV γ transition in 10B and 3853keV γ transition in 13C. Preliminary analysis indicates the discovery of a new resonance in low energy region. Research supported by NSF PHY-1430152, and JINA PHY-1419765.

  15. Wavevector-Frequency Analysis with Applications to Acoustics

    DTIC Science & Technology

    1994-01-01

    Turbulent Boundary Layer Pressure Measured by Microphone Arrays," Journal of the Acoustical Society of America, vol. 49, no. 3, March 1971 , pp. 862-877. 1...ARplications of Green’s FuntionsinScie,.-and Enginlering, Prentice-Hall, Inc., Englewood Hills, NJ, 1971 . 9. 3. Ffowcs-Williams et al., Modern Methods for...variables of a random process are kalled Joint w.merit ,. The m,n-th joint moment of the random variables, v and w, iz flefined by E ,N 1 f (aB) do d- where

  16. Apollo 11 Earth Training Exercises

    NASA Technical Reports Server (NTRS)

    1969-01-01

    In preparation of the nation's first lunar landing mission, Apollo 11 crew members underwent training to practice activities they would be performing during the mission. In this photograph, taken at the Manned Spacecraft Center in Houston, Texas, an engineer, Bob Mason, donned in a space suit, goes through some of those training exercises on the mock lunar surface. He performed activites similar to those planned for astronauts Neil Armstrong and Edwin Aldrin during their moon walk. The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  17. NASA Administrator Dan Goldin speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA Administrator Daniel S. Goldin addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

  18. Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.

    PubMed

    Lee, Hyun; Lei, Hao; Santarsiero, Bernard D; Gatuz, Joseph L; Cao, Shuyi; Rice, Amy J; Patel, Kavankumar; Szypulinski, Michael Z; Ojeda, Isabel; Ghosh, Arun K; Johnson, Michael E

    2015-06-19

    The Middle East Respiratory Syndrome coronavirus (MERS-CoV) papain-like protease (PLpro) blocking loop 2 (BL2) structure differs significantly from that of SARS-CoV PLpro, where it has been proven to play a crucial role in SARS-CoV PLpro inhibitor binding. Four SARS-CoV PLpro lead inhibitors were tested against MERS-CoV PLpro, none of which were effective against MERS-CoV PLpro. Structure and sequence alignments revealed that two residues, Y269 and Q270, responsible for inhibitor binding to SARS-CoV PLpro, were replaced by T274 and A275 in MERS-CoV PLpro, making critical binding interactions difficult to form for similar types of inhibitors. High-throughput screening (HTS) of 25 000 compounds against both PLpro enzymes identified a small fragment-like noncovalent dual inhibitor. Mode of inhibition studies by enzyme kinetics and competition surface plasmon resonance (SPR) analyses suggested that this compound acts as a competitive inhibitor with an IC50 of 6 μM against MERS-CoV PLpro, indicating that it binds to the active site, whereas it acts as an allosteric inhibitor against SARS-CoV PLpro with an IC50 of 11 μM. These results raised the possibility that inhibitor recognition specificity of MERS-CoV PLpro may differ from that of SARS-CoV PLpro. In addition, inhibitory activity of this compound was selective for SARS-CoV and MERS-CoV PLpro enzymes over two human homologues, the ubiquitin C-terminal hydrolases 1 and 3 (hUCH-L1 and hUCH-L3).

  19. Inactivation of the cloned potassium channel mouse Kv1.1 by the human Kv3.4 'ball' peptide and its chemical modification.

    PubMed Central

    Stephens, G J; Robertson, B

    1995-01-01

    1. This study used the whole-cell patch clamp technique to investigate the action of a 28-mer 'inactivation peptide' based on part of the N-terminal sequence of the human Kv3.4 K+ channel (hKv3.4 peptide) on the cloned mouse brain K+ channel mKv1.1 expressed in Chinese hamster ovary (CHO) cells, and compared this with the inactivation produced by Shaker B inactivation peptide (ShB peptide). 2. Inclusion of the hKv3.4 peptide in the patch electrode (320 microM) transformed non-inactivating mKv1.1 into a rapidly inactivating current. The voltage dependence of time constants of decay and steady-state inactivation induced by hKv3.4 peptide were characteristic of an 'A-type' K+ current. 3. The hKv3.4 peptide had no effect on the voltage dependence of activation of mKv1.1, with a mid-point of activation of -8 mV, and a slope factor of 15 mV. Steady-state inactivation curves had a mid-point of inactivation of -36 mV and a slope factor of -7 mV; the time constant of recovery from inactivation at -90 mV was 1.3 s. 4. The chemical modification reagents N-bromoacetamide (NBA, 100 microM) and chloramine-T (CL-T, 500 microM) had no effect on the fast inactivation of mKv1.1 induced by ShB peptide. In contrast, the inactivation caused by hKv3.4 peptide was removed by brief exposure to NBA and CL-T. 5. Chemical modification resulted in a hyperpolarizing shift of -8 mV (CL-T) and -11 mV (NBA) in the voltage dependence of activation of mKv1.1 in the presence of hKv3.4 peptide. 6. Chemical modification was critically dependent on the presence of a cysteine residue at position 6, and not position 24, of hKv3.4 peptide. 7. NBA and CL-T caused only a slight inhibition of unmodified mKv1.1 current with no significant effect on the voltage dependence of mKv1.1 activation, and also had no effect on channel deactivation at -90 mV. 8. Chemical modification experiments were consistent with a selective action on the hKv3.4 peptide itself, specifically at the cysteine residue at position 6

  20. Acquisition of High Field Nuclear Magnetic Resonance Spectrometers for Research in Molecular Structure, Function and Dynamics

    DTIC Science & Technology

    2012-09-01

    2005) Fibrinogen and fibrin. Adv Protein Chem 70, 247-299 2. Ariens, R. A., Lai, T. S., Weisel, J. W., Greenberg , C. S., and Grant, P. J. (2002) Role...matrix for the z-component of angular momentum # general case of spin j, Hilbert space has 2j+1 dimensions Iz j=5/2; Iz=diag([j:-1:-j

  1. 11 CFR 9008.11 - Examinations and audits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Examinations and audits. 9008.11 Section 9008.11 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: GENERAL... respond, as are provided for audits of publicly funded candidates under 11 CFR 9007.1 and 9038.1. ...

  2. 11 CFR 9008.11 - Examinations and audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Examinations and audits. 9008.11 Section 9008.11 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: GENERAL... respond, as are provided for audits of publicly funded candidates under 11 CFR 9007.1 and 9038.1. ...

  3. Technical Actions, Heart Rate, and Locomotor Activity in 7v7 and 8v8 Games for Female Youth Soccer Players.

    PubMed

    Ørntoft, Christina; Larsen, Malte N; Andersen, Thomas B; Rasmussen, Lasse S; Póvoas, Susana C A; Randers, Morten B; Krustrup, Peter

    2016-12-01

    Ørntoft, C, Larsen, MN, Andersen, TB, Rasmussen, LS, Póvoas, SCA, Randers, MB, and Krustrup, P. Technical actions, heart rate, and locomotor activity in 7v7 and 8v8 games for female youth soccer players. J Strength Cond Res 30(12): 3298-3303, 2016-The purpose of this study was to evaluate technical performance, heart rate (HR), and activity profile in 7v7 and 8v8 soccer games for 9- to 10-year-old girls (U11). A total of 24 female youth players participated in the study, all playing 20-minute 7v7 and 8v8 games with 160 and 223 m per player, respectively. Technical actions, HR, and activity profile were measured during the games using video filming, HR monitors, and 5-Hz Global positioning system (GPS) units. The number of technical actions was higher in 7v7 than in 8v8 games (34 ± 19 vs. 28 ± 14; p = 0.03; d = 0.37), as was the number of successful actions (25 ± 16 vs. 20 ± 12; p = 0.01; d = 0.35), with no difference in success rate for technical actions (70 ± 13 vs. 69 ± 14%; p = 0.63; d = 0.07). No differences were found between 7v7 and 8v8 in total distance covered (1,574 ± 251 and 1,622 ± 281 m; p = 0.66; d = 0.18), peak speed (19.5 ± 2.6 and 20.7 ± 1.5 km·h; p = 0.16; d = 0.56), mean HR values (85 ± 5 and 86 ± 6%HRpeak; p = 0.85; d = 0.18), and time of >90% HRpeak (37 ± 16 and 35 ± 14% of playing time; p = 0.70; d = 0.13). Distance covered at the highest running speeds of >16 km·h was lower in 7v7 than in 8v8 games (34 ± 24 vs. 63 ± 34 m; p = 0.018; d = 0.98), as was the number of entries into this speed zone (8 ± 5 vs. 13 ± 7; p = 0.006; d = 0.82). In conclusion, more technical actions and successful actions were observed in 7v7 than in 8v8 games, but players covered more ground with high-speed running in 8v8 games. This study also revealed that HR values were high in both game formats for U11 adolescent female players, with no difference between formats.

  4. Recombinant latcripin 11 of Lentinula edodes C91-3 suppresses the proliferation of various cancer cells.

    PubMed

    Gao, Yifan; Padhiar, Arshad Ahmed; Wang, Jia; Zhang, Wei; Zhong, Mintao; Liu, Ben; Kang, Zhijie; Wang, Xiaoli; Li, Xingyun; Huang, Min

    2018-02-05

    Lentinula edodes C91-3 is an edible mushroom that has demonstrated a remarkable anti-tumor effect in various cancer cells both in vitro and in vivo. In the present study, we report the ability of recombinant thioredoxin-like latcripin 11 (LP-11) of Lentinula edodes C91-3 to suppress the proliferation of various cancer cells. The LP-11 gene of Lentinula edodes C91-3 was cloned in the pET-32a(+) expression vector and expressed in a prokaryotic system. The expressed protein was refolded by gradual dialysis and purified by affinity gel filtration chromatography. The antioxidant activity of LP-11 was tested by 1,1-dipheny l-2-picrylhydrazyl (DPPH) assay. The anti-tumor activity of recombinant LP-11 was tested in eight kinds of tumor cell lines by CCK-8 assay. Recombinant LP-11 significantly suppressed the proliferation of various cancer cells, but not normal human umbilical vein endothelial cells. Human lymphoma U937 cells exhibited the most sensitivity to LP-11 protein. U937 cell apoptosis was assessed by Annexin V staining coupled with flow cytometry, and mitochondrial morphology was analyzed by light and electron microscopy. It was revealed that recombinant LP-11 induced apoptosis in human leukemic monocyte lymphoma U937 cells. Our findings suggest that recombinant LP-11 is a promising agent for the treatment of lymphoma. Copyright © 2017. Published by Elsevier B.V.

  5. Y-TZP ceramic processing from coprecipitated powders: a comparative study with three commercial dental ceramics.

    PubMed

    Lazar, Dolores R R; Bottino, Marco C; Ozcan, Mutlu; Valandro, Luiz Felipe; Amaral, Regina; Ussui, Valter; Bressiani, Ana H A

    2008-12-01

    (1) To synthesize 3mol% yttria-stabilized zirconia (3Y-TZP) powders via coprecipitation route, (2) to obtain zirconia ceramic specimens, analyze surface characteristics, and mechanical properties, and (3) to compare the processed material with three reinforced dental ceramics. A coprecipitation route was used to synthesize a 3mol% yttria-stabilized zirconia ceramic processed by uniaxial compaction and pressureless sintering. Commercially available alumina or alumina/zirconia ceramics, namely Procera AllCeram (PA), In-Ceram Zirconia Block (CAZ) and In-Ceram Zirconia (IZ) were chosen for comparison. All specimens (6mmx5mmx5mm) were polished and ultrasonically cleaned. Qualitative phase analysis was performed by XRD and apparent densities were measured on the basis of Archimedes principle. Ceramics were also characterized using SEM, TEM and EDS. The hardness measurements were made employing Vickers hardness test. Fracture toughness (K(IC)) was calculated. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test (alpha=0.05). ANOVA revealed that the Vickers hardness (p<0.0001) and fracture toughness (p<0.0001) were affected by the ceramic materials composition. It was confirmed that the PA ceramic was constituted of a rhombohedral alumina matrix, so-called alpha-alumina. Both CAZ and IZ ceramics presented tetragonal zirconia and alpha-alumina mixture of phases. The SEM/EDS analysis confirmed the presence of aluminum in PA ceramic. In the IZ and CAZ ceramics aluminum, zirconium and cerium in grains involved by a second phase containing aluminum, silicon and lanthanum were identified. PA showed significantly higher mean Vickers hardness values (H(V)) (18.4+/-0.5GPa) compared to vitreous CAZ (10.3+/-0.2GPa) and IZ (10.6+/-0.4GPa) ceramics. Experimental Y-TZP showed significantly lower results than that of the other monophased ceramic (PA) (p<0.05) but it showed significantly higher fracture toughness (6.0+/-0.2MPam(1/2)) values when compared to the

  6. Outburst of the recurrent nova V745 Sco

    NASA Astrophysics Data System (ADS)

    Waagen, Elizabeth O.

    2014-02-01

    The outburst of the recurrent nova V745 Sco (Nova Sco 1937) by Rod Stubbings (Tetoora Road, VIC, Australia) at visual magnitude 9.0 on 2014 February 6.694 UT is reported. This recurrent nova is fading quickly. Follow-up observations of all types (visual, CCD, DSLR) are strongly encouraged, as is spectroscopy; fast time-series of this nova may be useful to detect possible flaring activity as was observed during the outburst of U Scorpii in 2010. Coincident time-series by multiple observers would be most useful for such a study, with a V-filter being preferred. Observations reported to the AAVSO International Database show V745 Sco at visual mag. 10.2 on 2014 Feb. 07.85833 UT (A. Pearce, Nedlands, W. Australia). Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. Previous outbursts occurred in 1937 and 1989. The 1937 outburst was detected in 1958 (in decline at magnitude 11.0 on 1937 May 11.1 UT; outburst had occurred within the previous 19 days) by Lukas Plaut on plates taken by Hendrik van Gent at the Leiden Observatory; the object was announced as Nova Sco 1937 and later assigned the GCVS name V745 Sco. The 1989 outburst was detected on 1989 August 1.55 UT by Mati Morel (MMAT, Thornton, NSW, Australia) at visual magnitude 10.4 and in decline. Dr. Bradley Schaefer (Louisiana State University) reports (2010ApJS..187..275S) in his comprehensive analysis of the 10 known galactic recurrent novae (including V745 Sco) that the median interval between recurrent novae outbursts is 24 years. The interval since the 1989 outburst of V745 Sco is 24.10 years. See the Alert Notice for additional visual and multicolor photometry and for more details.

  7. 11 CFR 9004.11 - Winding down costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Winding down costs. 9004.11 Section 9004.11... FINANCING ENTITLEMENT OF ELIGIBLE CANDIDATES TO PAYMENTS; USE OF PAYMENTS § 9004.11 Winding down costs. (a) Winding down costs. Winding down costs are costs associated with the termination of the candidate's...

  8. 11 CFR 9034.11 - Winding down costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 11 Federal Elections 1 2012-01-01 2012-01-01 false Winding down costs. 9034.11 Section 9034.11... MATCHING FUND ENTITLEMENTS § 9034.11 Winding down costs. (a) Winding down costs. Winding down costs are... administrative costs associated with winding down the campaign, including office space rental, staff salaries...

  9. 11 CFR 9034.11 - Winding down costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 11 Federal Elections 1 2014-01-01 2014-01-01 false Winding down costs. 9034.11 Section 9034.11... MATCHING FUND ENTITLEMENTS § 9034.11 Winding down costs. (a) Winding down costs. Winding down costs are... administrative costs associated with winding down the campaign, including office space rental, staff salaries...

  10. 11 CFR 9004.11 - Winding down costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 11 Federal Elections 1 2014-01-01 2014-01-01 false Winding down costs. 9004.11 Section 9004.11... FINANCING ENTITLEMENT OF ELIGIBLE CANDIDATES TO PAYMENTS; USE OF PAYMENTS § 9004.11 Winding down costs. (a) Winding down costs. Winding down costs are costs associated with the termination of the candidate's...

  11. 11 CFR 9004.11 - Winding down costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Winding down costs. 9004.11 Section 9004.11... FINANCING ENTITLEMENT OF ELIGIBLE CANDIDATES TO PAYMENTS; USE OF PAYMENTS § 9004.11 Winding down costs. (a) Winding down costs. Winding down costs are costs associated with the termination of the candidate's...

  12. 11 CFR 9004.11 - Winding down costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 11 Federal Elections 1 2013-01-01 2012-01-01 true Winding down costs. 9004.11 Section 9004.11... FINANCING ENTITLEMENT OF ELIGIBLE CANDIDATES TO PAYMENTS; USE OF PAYMENTS § 9004.11 Winding down costs. (a) Winding down costs. Winding down costs are costs associated with the termination of the candidate's...

  13. 11 CFR 9034.11 - Winding down costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 11 Federal Elections 1 2013-01-01 2012-01-01 true Winding down costs. 9034.11 Section 9034.11... MATCHING FUND ENTITLEMENTS § 9034.11 Winding down costs. (a) Winding down costs. Winding down costs are... administrative costs associated with winding down the campaign, including office space rental, staff salaries...

  14. 11 CFR 9034.11 - Winding down costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Winding down costs. 9034.11 Section 9034.11... MATCHING FUND ENTITLEMENTS § 9034.11 Winding down costs. (a) Winding down costs. Winding down costs are... administrative costs associated with winding down the campaign, including office space rental, staff salaries...

  15. 11 CFR 9034.11 - Winding down costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Winding down costs. 9034.11 Section 9034.11... MATCHING FUND ENTITLEMENTS § 9034.11 Winding down costs. (a) Winding down costs. Winding down costs are... administrative costs associated with winding down the campaign, including office space rental, staff salaries...

  16. 11 CFR 9004.11 - Winding down costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 11 Federal Elections 1 2012-01-01 2012-01-01 false Winding down costs. 9004.11 Section 9004.11... FINANCING ENTITLEMENT OF ELIGIBLE CANDIDATES TO PAYMENTS; USE OF PAYMENTS § 9004.11 Winding down costs. (a) Winding down costs. Winding down costs are costs associated with the termination of the candidate's...

  17. SUPPLEMENTAL ANALYSES FOR SOLVENT HOLD TANK SAMPLES MCU-11-314, MCU-11-315, MCU-11-316, MCU-11-317, MCU-11-318 AND MCU-11-319

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T.; Washington, A; . Fondeur, F.

    2011-09-29

    Savannah River National Laboratory (SRNL) periodically analyses solvent samples from Modular Caustic-Side Solvent Extraction Unit (MCU) in support of continuing operations. A quarterly analysis of the solvent is required to maintain solvent composition within specifications. Analytical results of the analyses of Solvent Hold Tank (SHT) samples MCU-11-314, MCU-11-315, MCU-11-316, MCU-11-317, MCU-11-318 and MCU-11-319 have been previously reported. MCU has experienced a modest decline in cesium removal efficiency while processing the current feed, 'Macrobatch 3'. While the target decontamination factor (DF) is 200, the fiscal year 2011 DF average is 161. The results of the prior solvent analysis report did notmore » identify a specific factor that would correlate with the poor cesium decontamination beyond a low concentration of the suppressor, trioctylamine. New analyses of the quarterly sample are reported in this document, as well as a cross-check of {sup 137}Cs measurements for SRNL and F/H lab. Furthermore, in an attempt to discover the reason for the decline in DF at MCU, SRNL was tasked with analyzing numerous Caustic Wash Tank (CWT) and chemical feed samples.« less

  18. Therapeutic value of lymph node dissection for right middle lobe non-small-cell lung cancer

    PubMed Central

    Kuroda, Hiroaki; Mun, Mingyon; Motoi, Noriko; Ishikawa, Yuichi; Nakagawa, Ken; Yatabe, Yasushi; Okumura, Sakae

    2016-01-01

    Background Superior mediastinal and #11i lymph node (LN) metastases are adverse prognostic factors in patients with middle lobe lung cancer. We aimed to clarify the benefit of thorough lymphadenectomy by LN station or zone in middle lobe non-small-cell lung cancer (NSCLC). Methods Among 295 patients who underwent pulmonary resection and thorough lymphadenectomy for primary right middle lobe (RML) NSCLC at two institutions, we enrolled 68 patients (33 men, 35 women) and retrospectively studied their data. We divided each N1 location (i.e., #10, #11s and #11i) into N1(−)N2(+) and N1(+)N2(+) and divided the #12m location into N1(+)N2(−), N1(−)N2(+) and N1(+)N2(+). Results Interlobar node involvement was rare in pN1 NSCLC when compared with that in other N1 nodes. Lymph node dissection (LND) was beneficial when the hilar zone (HZ)/interlobar zone (IZ) LNs were located at the intermediate point of the upper zones (UZs) and subcarinal zones (SCZs), with the therapeutic benefit at the SCZ being 2.8-fold higher than that at the UZ and 9.7-fold higher than that at the lower zone (LZ). Furthermore, LND evidently had greater therapeutic value for the SCZ than the UZ, which was compatible with skip N2 metastases. Conclusions For middle lobe NSCLC, mediastinal LND should be considered a priority in the SCZ than in the UZ. Moreover, the HZ/IZ is central to unfavourable prognoses in patients with pN2 middle lobe NSCLC. PMID:27162652

  19. A Role for MINIYO and QUATRE-QUART2 in the Assembly of RNA Polymerases II, IV, and V in Arabidopsis.

    PubMed

    Li, Yaoxi; Yuan, Yuxiang; Fang, Xiaofeng; Lu, Xiuli; Lian, Bi; Zhao, Gaozhan; Qi, Yijun

    2018-02-01

    RNA polymerases IV and V (Pol IV and Pol V) are required for the generation of noncoding RNAs in RNA-directed DNA methylation (RdDM). Their subunit compositions resemble that of Pol II. The mechanism and accessory factors involved in their assembly remain largely unknown. In this study, we identified mutant alleles of MINIYO ( IYO ), QUATRE-QUART2 ( QQT2 ), and NUCLEAR RNA POLYMERASE B11/D11/E11 ( NRPB/D/E11 ) that cause defects in RdDM in Arabidopsis thaliana We found that Pol IV-dependent small interfering RNAs and Pol V-dependent transcripts were greatly reduced in the mutants. NRPE1, the largest subunit of Pol V, failed to associate with other Pol V subunits in the iyo and qqt2 mutants, suggesting the involvement of IYO and QQT2 in Pol V assembly. In addition, we found that IYO and QQT2 were mutually dependent for their association with the NRPE3 subassembly prior to the assembly of Pol V holoenzyme. Finally, we show that IYO and QQT2 are similarly required for the assembly of Pol II and Pol IV. Our findings reveal IYO and QQT2 as cofactors for the assembly of Pol II, Pol IV, and Pol V and provide mechanistic insights into how RNA polymerases are assembled in plants. © 2018 American Society of Plant Biologists. All rights reserved.

  20. Unraveling flp-11/flp-32 dichotomy in nematodes.

    PubMed

    Atkinson, Louise E; Miskelly, Iain R; Moffett, Christy L; McCoy, Ciaran J; Maule, Aaron G; Marks, Nikki J; Mousley, Angela

    2016-10-01

    FMRFamide-like peptide (FLP) signalling systems are core to nematode neuromuscular function. Novel drug discovery efforts associated with nematode FLP/FLP receptor biology are advanced through the accumulation of basic biological data that can reveal subtle complexities within the neuropeptidergic system. This study reports the characterisation of FMRFamide-like peptide encoding gene-11 (flp-11) and FMRFamide-like peptide encoding gene-32 (flp-32), two distinct flp genes which encode the analogous peptide, AMRN(A/S)LVRFamide, in multiple nematode species - the only known example of this phenomenon within the FLPergic system of nematodes. Using bioinformatics, in situ hybridisation, immunocytochemistry and behavioural assays we show that: (i) flp-11 and -32 are distinct flp genes expressed individually or in tandem across multiple nematode species, where they encode a highly similar peptide; (ii) flp-11 does not appear to be the most widely expressed flp in Caenorhabditis elegans; (iii) in species expressing both flp-11 and flp-32, flp-11 displays a conserved, restricted expression pattern across nematode clades and lifestyles; (iv) in species expressing both flp-11 and flp-32, flp-32 expression is more widespread and less conserved than flp-11; (v) in species expressing only flp-11, the flp-11 expression profile is more similar to the flp-32 profile observed in species expressing both; and (vi) FLP-11 peptides inhibit motor function in multiple nematode species. The biological significance and evolutionary origin of flp-11 and -32 peptide duplication remains unclear despite attempts to identify a common ancestor; this may become clearer as the availability of genomic data improves. This work provides insight into the complexity of the neuropeptidergic system in nematodes, and begins to examine how nematodes may compensate for structural neuronal simplicity. From a parasite control standpoint, this work underscores the importance of basic biological data, and has

  1. Detection of Multiple Innervation Zones from Multi-Channel Surface EMG Recordings with Low Signal-to-Noise Ratio Using Graph-Cut Segmentation.

    PubMed

    Marateb, Hamid Reza; Farahi, Morteza; Rojas, Monica; Mañanas, Miguel Angel; Farina, Dario

    2016-01-01

    Knowledge of the location of muscle Innervation Zones (IZs) is important in many applications, e.g. for minimizing the quantity of injected botulinum toxin for the treatment of spasticity or for deciding on the type of episiotomy during child delivery. Surface EMG (sEMG) can be noninvasively recorded to assess physiological and morphological characteristics of contracting muscles. However, it is not often possible to record signals of high quality. Moreover, muscles could have multiple IZs, which should all be identified. We designed a fully-automatic algorithm based on the enhanced image Graph-Cut segmentation and morphological image processing methods to identify up to five IZs in 60-ms intervals of very-low to moderate quality sEMG signal detected with multi-channel electrodes (20 bipolar channels with Inter Electrode Distance (IED) of 5 mm). An anisotropic multilayered cylinder model was used to simulate 750 sEMG signals with signal-to-noise ratio ranging from -5 to 15 dB (using Gaussian noise) and in each 60-ms signal frame, 1 to 5 IZs were included. The micro- and macro- averaged performance indices were then reported for the proposed IZ detection algorithm. In the micro-averaging procedure, the number of True Positives, False Positives and False Negatives in each frame were summed up to generate cumulative measures. In the macro-averaging, on the other hand, precision and recall were calculated for each frame and their averages are used to determine F1-score. Overall, the micro (macro)-averaged sensitivity, precision and F1-score of the algorithm for IZ channel identification were 82.7% (87.5%), 92.9% (94.0%) and 87.5% (90.6%), respectively. For the correctly identified IZ locations, the average bias error was of 0.02±0.10 IED ratio. Also, the average absolute conduction velocity estimation error was 0.41±0.40 m/s for such frames. The sensitivity analysis including increasing IED and reducing interpolation coefficient for time samples was performed

  2. Detection of Multiple Innervation Zones from Multi-Channel Surface EMG Recordings with Low Signal-to-Noise Ratio Using Graph-Cut Segmentation

    PubMed Central

    Farahi, Morteza; Rojas, Monica; Mañanas, Miguel Angel; Farina, Dario

    2016-01-01

    Knowledge of the location of muscle Innervation Zones (IZs) is important in many applications, e.g. for minimizing the quantity of injected botulinum toxin for the treatment of spasticity or for deciding on the type of episiotomy during child delivery. Surface EMG (sEMG) can be noninvasively recorded to assess physiological and morphological characteristics of contracting muscles. However, it is not often possible to record signals of high quality. Moreover, muscles could have multiple IZs, which should all be identified. We designed a fully-automatic algorithm based on the enhanced image Graph-Cut segmentation and morphological image processing methods to identify up to five IZs in 60-ms intervals of very-low to moderate quality sEMG signal detected with multi-channel electrodes (20 bipolar channels with Inter Electrode Distance (IED) of 5 mm). An anisotropic multilayered cylinder model was used to simulate 750 sEMG signals with signal-to-noise ratio ranging from -5 to 15 dB (using Gaussian noise) and in each 60-ms signal frame, 1 to 5 IZs were included. The micro- and macro- averaged performance indices were then reported for the proposed IZ detection algorithm. In the micro-averaging procedure, the number of True Positives, False Positives and False Negatives in each frame were summed up to generate cumulative measures. In the macro-averaging, on the other hand, precision and recall were calculated for each frame and their averages are used to determine F1-score. Overall, the micro (macro)-averaged sensitivity, precision and F1-score of the algorithm for IZ channel identification were 82.7% (87.5%), 92.9% (94.0%) and 87.5% (90.6%), respectively. For the correctly identified IZ locations, the average bias error was of 0.02±0.10 IED ratio. Also, the average absolute conduction velocity estimation error was 0.41±0.40 m/s for such frames. The sensitivity analysis including increasing IED and reducing interpolation coefficient for time samples was performed

  3. Apollo 11 Astronauts Share Laughs With U.S. President Nixon

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF). Here the quarantined Apollo 11 crew members (l to r) Armstrong, Collins, and Aldrin, and U.S. President Richard Milhous Nixon share laughs over a comment made by fellow astronaut Frank Borman, Apollo 8 commander. The president was aboard the recovery vessel awaiting return of the astronauts. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  4. U.S. President Richard Milhous Nixon Watches Apollo 11 Recovery

    NASA Technical Reports Server (NTRS)

    1969-01-01

    U.S. President Richard Milhous Nixon (center), aboard the U.S.S. Hornet aircraft carrier, used binoculars to watch the Apollo 11 Lunar Mission Recovery. Standing next to the President is astronaut Frank Borman, Apollo 8 Commander. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted to safety aboard the U.S.S. Hornet where they were quartered in a Mobile Quarantine Facility (MQF) for 21 days post mission. The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  5. Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.

    PubMed

    Hodgson, Adam; Terentyev, Yaroslav; Johnson, Rebecca A; Bishop-Bailey, Anna; Angevin, Thibaut; Croucher, Adam; Goldman, Alastair S H

    2011-02-07

    During meiosis DNA double-strand breaks (DSBs) are induced and repaired by homologous recombination to create gene conversion and crossover products. Mostly these DSBs are made by Spo11, which covalently binds to the DSB ends. More rarely in Saccharomyces cerevisiae, other meiotic DSBs are formed by self-homing endonucleases such as VDE, which is site specific and does not covalently bind to the DSB ends. We have used experimentally located VDE-DSB sites to analyse an intermediate step in homologous recombination, resection of the single-strand ending 5' at the DSB site. Analysis of strains with different mutant alleles of MRE11 (mre11-58S and mre11-H125N) and deleted for EXO1 indicated that these two nucleases make significant contributions to repair of VDE-DSBs. Physical analysis of single-stranded repair intermediates indicates that efficient initiation and processivity of resection at VDE-DSBs require both Mre11 and Exo1, with loss of function for either protein causing severe delay in resection. We propose that these experiments model what happens at Spo11-DSBs after removal of the covalently bound protein, and that Mre11 and Exo1 are the major nucleases involved in creating resection tracts of widely varying lengths typical of meiotic recombination. Copyright © 2010 Elsevier B.V. All rights reserved.

  6. 11 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Purpose and scope. 1.1 Section 1.1 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.1 Purpose and scope. (a) The purpose of this part is... 43064, Sept. 29, 1976, as amended at 45 FR 21209, Apr. 1, 1980] ...

  7. 11 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Purpose and scope. 1.1 Section 1.1 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.1 Purpose and scope. (a) The purpose of this part is... 43064, Sept. 29, 1976, as amended at 45 FR 21209, Apr. 1, 1980] ...

  8. 11 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 11 Federal Elections 1 2012-01-01 2012-01-01 false Purpose and scope. 1.1 Section 1.1 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.1 Purpose and scope. (a) The purpose of this part is... 43064, Sept. 29, 1976, as amended at 45 FR 21209, Apr. 1, 1980] ...

  9. 11 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 11 Federal Elections 1 2014-01-01 2014-01-01 false Purpose and scope. 1.1 Section 1.1 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.1 Purpose and scope. (a) The purpose of this part is... 43064, Sept. 29, 1976, as amended at 45 FR 21209, Apr. 1, 1980] ...

  10. 11 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 11 Federal Elections 1 2013-01-01 2012-01-01 true Purpose and scope. 1.1 Section 1.1 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.1 Purpose and scope. (a) The purpose of this part is... 43064, Sept. 29, 1976, as amended at 45 FR 21209, Apr. 1, 1980] ...

  11. Liftoff of the Apollo 11 lunar landing mission

    NASA Image and Video Library

    1969-07-16

    S69-39958 (16 July 1969) --- A 70mm Airborne Lightweight Optical Tracking System (ALOTS) camera, mounted in a pod on a cargo door of a U.S. Air Force EC-135N aircraft, photographed this event in the early moments of the Apollo 11 launch. The mated Apollo spacecraft and Saturn V second (S-II) and third (S-IVB) stages pull away from the expended first (S-1C) stage. Separation occurred at an altitude of about 38 miles, some 55 miles downrange from Cape Kennedy. The aircraft's pod is 20 feet long and 5 feet in diameter. The crew of the Apollo 11 lunar landing mission are astronauts Neil A. Armstrong, Michael Collins, and Edwin E. Aldrin Jr.

  12. Biocatalyst mediated production of 6β,11α-dihydroxy derivatives of 4-ene-3-one steroids.

    PubMed

    Kolet, Swati P; Niloferjahan, Siddiqui; Haldar, Saikat; Gonnade, Rajesh; Thulasiram, Hirekodathakallu V

    2013-11-01

    Biotransformation of steroids with 4-ene-3-one functionality such as progesterone (I), testosterone (II), 17α-methyltestosterone (III), 4-androstene-3,17-dione (IV) and 19-nortestosterone (V) were studied by using a fungal system belonging to the genera of Mucor (M881). The fungal system efficiently and quantitatively converted these steroids in regio- and stereo-selective manner into corresponding 6β,11α-dihydroxy compounds. Time course experiments suggested that the transformation was initiated by hydroxylation at 6β- or 11α-(10β-hydroxy in case of V) to form monohydroxy derivatives which upon prolonged incubation were converted into corresponding 6β,11α-dihydroxy derivatives. The fermentation studies carried out using 5L table-top fermentor with substrates (I and II) clearly indicates that 6β,11α-dihydroxy derivatives of steroids with 4-ene-3-one functionality can be produced in large scale by using M881. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong is the center of attention at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

  14. The Effect of a Pulsed Interference Signal on an Adaptive Array.

    DTIC Science & Technology

    1981-04-01

    eigenvectors exist.) Using a spectral decomp- osition formula [10,11], we may write e-kM in the form -kM -k(T- )-kpo 3 -kg i (e -k = e a : .iZ e eie i , (28...N 0 (No/T b) In addition, for this analysis we shall assume the interference power at the array output has the same effect on detector performance... Sensitive Adaptive Array," to appear in IEEE Trans. Antennas and Propagation. 7. R.T. Compton, Jr., "The Tripole Antenna - An Adaptive Array with Full

  15. Best Value Acquisition Symposium and Continuous Acquisition and Life Cycle Support (CALS) Update Held in Eatontown, New Jersey on November 17-18, 1993

    DTIC Science & Technology

    1993-11-18

    Satellite Commications/Milstar AMSEL- ACCA -A-AE Fort Mcimicth, New Jersey 07703 (908) 532-5486 MR. ROGER S. BERGE HQ, US Amy Ccauunicaticns-Electranics...o 0 0m IL W 0 0 2o Z 0 x0 0~LI 0i- 1 0 F8 20 (A ZI-m 0. WO 0 L 0>11 Z 0 0 A ’o m0J X I-z 4wE 0z. z 0OOL~( WZZ c Wx1>- MiAi Oz OMOXzO ILCl) 0>M CO)( 0

  16. Combinatorial Geometry Computer Models of Sitting and Standing Crew Personnel

    DTIC Science & Technology

    1981-08-01

    Anthropometry - 1976,11 US Army Natick Laboratories Technical Report No. 72-51-CE, December, 1971. 10 4-). 0 4-3 4-3 =- -mr - 4. . 0 C- 4- WW~ C0 0 4...t.4IwI-4S-4 4A Vs x 1-4~ i-I a~ 4 >- *E0. .- ~-- I- u ~.Iz 4 www ou u0 W(. cc 0 I- I-W OW(AWWW Wj oz 0 WW4 X XL U. WEE.-J. d- 1.4 o ZZ W W w LL to4W0

  17. Electroproduction of {eta} mesons in the S{sub 11}(1535) resonance region at high momentum transfer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dalton, M. M.; Adams, G. S.; Moziak, B.

    2009-07-15

    The differential cross section for the process p(e,e{sup '}p){eta} has been measured at Q{sup 2}{approx}5.7 and 7.0(GeV/c){sup 2} for center-of-mass energies from threshold to 1.8 GeV, encompassing the S{sub 11}(1535) resonance, which dominates the channel. This is the highest momentum-transfer measurement of this exclusive process to date. The helicity-conserving transition amplitude A{sub 1/2}, for the production of the S{sub 11}(1535) resonance, is extracted from the data. Within the limited Q{sup 2} now measured, this quantity appears to begin scaling as Q{sup -3}--a predicted, but not definitive, signal of the dominance of perturbative QCD at Q{sup 2}{approx}5 (GeV/c){sup 2}.

  18. Nuclear level densities in {sup 47}V, {sup 48}V, {sup 49}V, {sup 53}Mn, and {sup 54}Mn from neutron evaporation spectra

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhuravlev, B. V., E-mail: zhurav@ippe.ru; Lychagin, A. A.; Titarenko, N. N.

    The spectra of neutrons from the (p, n) reactions on {sup 47}Ti, {sup 48}Ti, {sup 49}Ti, {sup 53}Cr, and {sup 54}Cr nuclei were measured in the proton-energy range 7-11 MeV. The measurements were performed with the aid of a fast-neutron spectrometer by the time-of-flight method over the base of the EGP-15 tandem accelerator of the Institute for Physics and Power Engineering (IPPE, Obninsk). Owing to a high resolution and a high stability of the time-of-flight spectrometer used, low-lying discrete levels could be identified reliably along with a continuum section of neutron spectra. An analysis of measured data was performed withinmore » the statistical equilibrium and preequilibrium models of nuclear reactions. The relevant calculations were performed by using the exact formalism of Hauser-Feshbach statistical theory supplemented with the generalized model of a superfluid nucleus, the back-shifted Fermi gas model, and the Gilbert-Cameron composite formula for the nuclear level density. The nuclear level densities for {sup 47}V, {sup 48}V, {sup 49}V, {sup 53}Mn, and {sup 54}Mn were determined along with their energy dependences and model parameters. The results are discussed together with available experimental data and recommendations of model systematics.« less

  19. Anisotropy of cosmic rays of energy 10 (15) eV to 10 (17) eV observed at Akeno

    NASA Technical Reports Server (NTRS)

    Kifune, T.; Nishijima, K.; Hara, T.; Hatano, Y.; Hayashida, N.; Honda, M.; Kamata, K.; Matsubara, Y.; Nagano, M.; Tanahashi, G.

    1985-01-01

    Anisotropy of cosmic rays is studied with extensive air showers (EAS) data by muon trigger. The present results support those obtained by electron trigger which suggest the significant anisotropy of second harmonics with phase around 100 deg in right ascension for showers of 10 to the 16th power - 10 to the 17th power eV, and predominant arrival direction of 230 deg in right ascension for muon-rich showers. It seems that the phase of the first harmonics in the energy range below 10 to the 11th power eV is about 300 deg in right ascension and the second harmonics near 6 x 10 to the 14th power eV is statistically significant with an amplitude of 0.39 + or - 0.13% in direction of 83 + or - 10 deg in right ascension.

  20. 75 FR 47709 - Amendment of VOR Federal Airways V-8, V-14, V-38, V-47, V-279, and V-422 in the Vicinity of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ...-0709; Airspace Docket No. 09-AGL-28] RIN 2120-AA66 Amendment of VOR Federal Airways V-8, V-14, V-38, V-47, V-279, and V-422 in the Vicinity of Findlay, OH AGENCY: Federal Aviation Administration (FAA... Range (VOR) Federal Airways V-8, V-14, V-38, V-47, V- 279, and V-422 in the vicinity of Findlay, OH. The...

  1. Innervation zones of fasciculating motor units: observations by a linear electrode array.

    PubMed

    Jahanmiri-Nezhad, Faezeh; Barkhaus, Paul E; Rymer, William Z; Zhou, Ping

    2015-01-01

    This study examines the innervation zone (IZ) in the biceps brachii muscle in healthy subjects and those with amyotrophic lateral sclerosis (ALS) using a 20-channel linear electromyogram (EMG) electrode array. Raster plots of individual waveform potentials were studied to estimate the motor unit IZ. While this work mainly focused on fasciculation potentials (FPs), a limited number of motor unit potentials (MUPs) from voluntary activity of 12 healthy and seven ALS subjects were also examined. Abnormal propagation of MUPs and scattered IZs were observed in fasciculating units, compared with voluntarily activated MUPs in healthy and ALS subjects. These findings can be related to muscle fiber reinnervation following motor neuron degeneration in ALS and the different origin sites of FPs compared with voluntary MUPs.

  2. Innervation zones of fasciculating motor units: observations by a linear electrode array

    PubMed Central

    Jahanmiri-Nezhad, Faezeh; Barkhaus, Paul E.; Rymer, William Z.; Zhou, Ping

    2015-01-01

    This study examines the innervation zone (IZ) in the biceps brachii muscle in healthy subjects and those with amyotrophic lateral sclerosis (ALS) using a 20-channel linear electromyogram (EMG) electrode array. Raster plots of individual waveform potentials were studied to estimate the motor unit IZ. While this work mainly focused on fasciculation potentials (FPs), a limited number of motor unit potentials (MUPs) from voluntary activity of 12 healthy and seven ALS subjects were also examined. Abnormal propagation of MUPs and scattered IZs were observed in fasciculating units, compared with voluntarily activated MUPs in healthy and ALS subjects. These findings can be related to muscle fiber reinnervation following motor neuron degeneration in ALS and the different origin sites of FPs compared with voluntary MUPs. PMID:26029076

  3. Pure Rotational CARS Thermometry Studies of Low Temperature Oxidation Kinetics in Air and Ethene-Air Nanosecond Pulse Discharge Plasmas

    DTIC Science & Technology

    2010-01-01

    12600 12800 13000 13200 N or m al iz ed In te ns ity 0.0 0.2 0.4 0.6 0.8 1.0 1.2 Beam Contribution Raman Shift...wavenumbers) 0 200 400 600 800 0.0 0.2 0.4 0.6 0.8 1.0 1.2 Single Shot Wavenumbers 12200 12400 12600 12800 13000 N or m al iz ed In te ns ity 0.0 0.2 0.4...0.6 0.8 1.0 1.2 10 Shot Average Wavenumbers 12600 12800 13000 13200 N or m al iz ed In te ns ity 0.0 0.2 0.4 0.6 0.8 1.0 1.2 28 1.0E-7 1.0E-6

  4. Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Barrington, Isld-Williamson, Texas). Part 11

    DTIC Science & Technology

    1994-03-01

    CyC)444 11_ n (0m m m ~ V c0 ( 40 00-4.- 4 -0 -4 -42 z O CAO1000Z de ON I~si CON1 02 0000000000 00 >-0000000000000 Cl!0 X0000 C toON Iiz Cci OOOOOOO 0...C0OV N 4 v de . d 00-49I 0~Ia I r*U- 4 4444 4 4 00ON 0 0 cThII1 600000 N 0004 ULg4 4(< . Co :: en UU4 4 P44 4r,0CUU0 0 0 0 If 1 U 4cqu 0 NIUJ-MG00 0 0 0...m CO) 0 Cq ’D rý 100111OLn mo If I Ca 0 Go 11 om 000 00 . 0 V 0-4 0Ln(DN - 0 M 0040 - 0 m 0OV(D - 0 (D if I cacao 11 z It Z Ln Z Ln-i C r4% z to

  5. Magnesium Technology and Manufacturing for Ultra Lightweight Armored Ground Vehicles

    DTIC Science & Technology

    2009-02-01

    different metals and equal areal densities. Metal Plate Thickness, in Plate Stiffness, E6 lb/in RHA (Steel Armor) 0.245 0.08 Ti- 6Al - 4V 0.434 0.28...metal at a density of 1.74 g/cm3 that is approximately 1/5, 2/5, and 2/3 the weight of iron, titanium , and aluminum, respectively (Emley, 1966...al iz ed D en si ty Figure 1. Normalized densities comparison of magnesium alloys with 4340 steel and titanium alloy. Both Elektron WE43 and

  6. Artificial Intelligence -- Research and Applications.

    DTIC Science & Technology

    1976-06-01

    Determination of Minimum Cost Paths," IEEE Trans. Sys . Sci. Cybernetics, Vol. 4, No. 2, pp. 100-107. Hendrix, G. (1975), "Expanding the Utility of Semantic...PLANS E , IN, 7979 IZ)’. TE.R ATE RECOGNITION LASEHTAED LOCATION SENP PARTS ANO AAlYI CONIP E TELOMPL T FP NET SSTEMCOMPRS SY -STy 7974 ’T S ST7p -TO...EXTNDE 1: OUBLE -ETNE %AT,,RAL ~C’v LA ~t PB IV P6 TO T4 %~ ’ F" _______________________________________ SY ~STEM 7’j NTJt, E EPAk AAII IJ Aii SASSEVELY

  7. FY1994 DoD Statistical Report on the Military Retirement System

    DTIC Science & Technology

    1994-09-30

    OIL X. I UJ3 V >• i _JZ m < > CO 0. i < »— i </> ocn 1 M UJUJ i a CQQC i z IH * i o 31- tr- i z ZUJ... i 03<a I OIL I UJ3 > I -IZ 03 r 03 i < • co oea I H UIUI I • COCK I Z ZH I O 3H I Z ZUJ HtfHr- rHiHiH HtfMOCVJHHHHH K...eo<a UJ i OIL CtL i

  8. Closed-loop conductance scanning tunneling spectroscopy: demonstrating the equivalence to the open-loop alternative.

    PubMed

    Hellenthal, Chris; Sotthewes, Kai; Siekman, Martin H; Kooij, E Stefan; Zandvliet, Harold J W

    2015-01-01

    We demonstrate the validity of using closed-loop z(V) conductance scanning tunneling spectroscopy (STS) measurements for the determination of the effective tunneling barrier by comparing them to more conventional open-loop I(z) measurements. Through the development of a numerical model, the individual contributions to the effective tunneling barrier present in these experiments, such as the work function and the presence of an image charge, are determined quantitatively. This opens up the possibility of determining tunneling barriers of both vacuum and molecular systems in an alternative and more detailed manner.

  9. Adaptive Path Control of Surface Ships in Restricted Waters.

    DTIC Science & Technology

    1980-08-01

    and Fn=0.116-- Random Walk Disturbance Model 31 6. Optimal Gains for Tokyo Mazu at H/T=- and Fn=0.116-- Random Walk Disturbance Model 39 7. RMS Cost J...yaw mass moment of inertia [kgm 2 V =21 /pL nondimensional yaw mass moment of inertia zz zz J optimal control or Weighted Least-Squares cost function...J RMS cost , eq. (70) J 5yaw added mass moment of inertia [kgm 2 iz=2Jz/pL nondimensional yaw added mass moment of inertia zz zz K Kalman-Bucy state

  10. Near East/North Africa Report No. 2642.

    DTIC Science & Technology

    1982-10-19

    JPRS 82023 19 October 1982 Near East/North Africa Report No. 2642 0 0’- FBISl FOREIGN BROADCAST INFORMATION SERVICE NATIONAl TECHNICALINFORMATION...itI ’s Iz ioo. i ’ tI. xfr .1k3 r A V’ JPRS 82023. 19 October 1982 NEAR EAST/NORTH AFRICA REPORT No. 2642 CONTENTS OPEC AFFAIRS Arab Investment...and tri-.e-6~ve urzgrarme Uricer Pit lattef, Awl-Babta’i of Kjv.a’:. Ai Suda’ry. UALenk C’i-vee! %w te givqn "ho Chance Sliotokshyaond Siia-0a1y of

  11. Bilateral comparison of 10 V standards between the NSAI-NML (Ireland) and the BIPM, March 2014 (part of the ongoing BIPM key comparison BIPM.EM-K11.b)

    NASA Astrophysics Data System (ADS)

    Solve, S.; Chayramy, R.; Power, O.; Stock, M.

    2014-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.b, a comparison of the 10 V voltage reference standards of the BIPM and the National Standards Authority of Ireland-National Metrology Laboratory (NSAI-NML), Dublin, Ireland, was carried out in February and March 2014. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM_4 (Z4) and BIPM_5 (Z5), were transported by freight to NSAI-NML. At NSAI-NML, the reference standard for DC voltage at the 10 V level consists of a group of characterized Zener diode-based electronic voltage standards. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the group standard. At the BIPM the travelling standards were calibrated, before and after the measurements at NSAI-NML, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the value assigned to DC voltage standard by NSAI-NML, at the level of 10 V, at NSAI-NML, UNML, and that assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 10 March 2014. UNML - UBIPM = -0.64 µV uc = 1.35 µV, at 10 V where uc is thecombined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NSAI-NML,based on KJ-90, and the uncertainty related to the comparison. The comparison results show that the voltage standards maintained by NSAI-NML and the BIPM were equivalent, within their stated standard uncertainties, on the mean date of the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to

  12. Au11Re: A hollow or endohedral binary cluster?

    NASA Astrophysics Data System (ADS)

    MacLeod Carey, Desmond; Muñoz-Castro, Alvaro

    2018-06-01

    In this letter, we discussed the plausible formation of [Au11Re] as a superatom with an electronic structure accounted by the 1S21P61D10 shell order, denoting similar stability to [W@Au12]. The possible hollow or endohedral structures show a variable HOMO-LUMO gap according to the given structure (from 0.33 to 1.30 eV, at the PBE/ZORA level). Our results show that the energy minimum is an endohedral arrangement, where Re is encapsulated in a D3h-Au11 cage, retaining a higher gold-dopant stoichiometric ratio. This approach is useful for further rationalization and design of novel superatoms expanding the libraries of endohedral clusters.

  13. [11C]Harmine Binding to Brain Monoamine Oxidase A: Test-Retest Properties and Noninvasive Quantification.

    PubMed

    Zanderigo, Francesca; D'Agostino, Alexandra E; Joshi, Nandita; Schain, Martin; Kumar, Dileep; Parsey, Ramin V; DeLorenzo, Christine; Mann, J John

    2018-02-08

    Inhibition of the isoform A of monoamine oxidase (MAO-A), a mitochondrial enzyme catalyzing deamination of monoamine neurotransmitters, is useful in treatment of depression and anxiety disorders. [ 11 C]harmine, a MAO-A PET radioligand, has been used to study mood disorders and antidepressant treatment. However, [ 11 C]harmine binding test-retest characteristics have to date only been partially investigated. Furthermore, since MAO-A is ubiquitously expressed, no reference region is available, thus requiring arterial blood sampling during PET scanning. Here, we investigate [ 11 C]harmine binding measurements test-retest properties; assess effects of using a minimally invasive input function estimation on binding quantification and repeatability; and explore binding potentials estimation using a reference region-free approach. Quantification of [ 11 C]harmine distribution volume (V T ) via kinetic models and graphical analyses was compared based on absolute test-retest percent difference (TRPD), intraclass correlation coefficient (ICC), and identifiability. The optimal procedure was also used with a simultaneously estimated input function in place of the measured curve. Lastly, an approach for binding potentials quantification in absence of a reference region was evaluated. [ 11 C]harmine V T estimates quantified using arterial blood and kinetic modeling showed average absolute TRPD values of 7.7 to 15.6 %, and ICC values between 0.56 and 0.86, across brain regions. Using simultaneous estimation (SIME) of input function resulted in V T estimates close to those obtained using arterial input function (r = 0.951, slope = 1.073, intercept = - 1.037), with numerically but not statistically higher test-retest difference (range 16.6 to 22.0 %), but with overall poor ICC values, between 0.30 and 0.57. Prospective studies using [ 11 C]harmine are possible given its test-retest repeatability when binding is quantified using arterial blood. Results with SIME of

  14. Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T-cell receptor V beta gene products.

    PubMed Central

    Sen-Majumdar, A; Weissman, I L; Hansteen, G; Marian, J; Waller, E K; Lieberman, M

    1994-01-01

    We have investigated the phenotypic changes that take place during the process of neoplastic transformation in the thymocytes of C57BL/Ka mice infected by the radiation leukemia virus (RadLV). By the combined use of antibodies against the envelope glycoprotein gp70 of RadLV, the transformation-associated cell surface marker 1C11, and the CD3-T-cell receptor (TCR) complex, we found that in the RadLV-infected thymus, the earliest expression of viral gp70 is in 1C11hi cells; a small but significant percentage of these cells also express CD3. A first wave of viral replication, manifested by the expression of high levels of gp70 in thymocytes (over 70% positive), reaches a peak at 2 weeks; during this period, no significant changes are observed in the expression of 1C11 or CD3. The population of gp70+ cells is drastically reduced at 3 to 4 weeks after infection. However, a second cohort of gp70+ cells appears after 4 weeks, and these cells express high levels of 1C11 and TCR determinants as well. RadLV-induced lymphomas differ from normal thymocytes in their CD4 CD8 phenotype, with domination by one or more subsets. Characterization of TCR gene rearrangements in RadLV-induced lymphomas shows that most of these tumors are clonal or oligoclonal with respect to the J beta 2 TCR gene, while the J beta 1 TCR gene is rearranged in a minority (4 of 11) of lymphomas. TCR V beta repertoire analysis of 12 tumors reveals that 6 (50%) express exclusively the V beta 6 gene product, 2 (17%) are V beta 5+, and 1 (8%) each are V beta 8+ and V beta 9+. In normal C57BL/Ka mice, V beta 6 is expressed on 12%, V beta 5 is expressed on 9%, V beta 8 is expressed on 22%, and V beta 9 is expressed on 4% of TCRhi thymocytes. Thus, it appears that RadLV-induced thymic lymphomas are not randomly selected with respect to expressed TCR V beta type. Images PMID:8289345

  15. De novo microduplication at 22q11.21 in a patient with VACTERL association.

    PubMed

    Schramm, Charlotte; Draaken, Markus; Bartels, Enrika; Boemers, Thomas M; Aretz, Stefan; Brockschmidt, Felix F; Nöthen, Markus M; Ludwig, Michael; Reutter, Heiko

    2011-01-01

    The non-random association of vertebral defects (V), anorectal malformations (A), cardiac defects (C), tracheoesophageal fistula with esophageal atresia (TE), renal malformations (R), and limb defects (L) is termed VACTERL association. The aim of the present study was to identify microaberrations characterized by a loss or gain of genomic material that contribute to VACTERL association at a genome-wide level. Molecular karyotyping was performed in a cohort of 12 patients with anorectal malformations and at least two additional cardinal features of the VACTERL association. A de novo microduplication at chromosomal region 22q11.21 was identified in a patient presenting with three cardinal VACTERL features (V, A, R) and vesicoureteral reflux, penile hypospadias, caudal regression syndrome, and right-sided congenital equinovarus deformity. Chromosomal region 22q11.2 is known for its susceptibility to rearrangements. Associated syndromes include the velo-cardio-facial and DiGeorge deletion syndromes, and the complementary 22q11.2 duplication syndrome. The findings of the present study extend the phenotypic spectrum of the 22q11.2 duplication syndrome, and indicate that it also predisposes to VACTERL association. We discuss the overlap between the phenotypic features of our patient and those reported for other 22q11.2 aberrations, and propose that dosage-sensitive loci for all of these phenotypic features may reside on 22q11.2. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  16. Baculovirus LEF-11 nuclear localization signal is important for viral DNA replication.

    PubMed

    Chen, Tingting; Dong, Zhanqi; Hu, Nan; Hu, Zhigang; Dong, Feifan; Jiang, Yaming; Li, Jun; Chen, Peng; Lu, Cheng; Pan, Minhui

    2017-06-15

    Baculovirus LEF-11 is a small nuclear protein that is involved in viral late gene transcription and DNA replication. However, the characteristics of its nuclear localization signal and its impact on viral DNA replication are unknown. In the present study, systemic bioinformatics analysis showed that the baculovirus LEF-11 contains monopartite and bipartite classical nuclear localization signal sequences (cNLSs), which were also detected in a few alphabaculovirus species. Localization of representative LEF-11 proteins of four baculovirus genera indicated that the nuclear localization characteristics of baculovirus LEF-11 coincided with the predicted results. Moreover, Bombyx mori nucleopolyhedrovirus (BmNPV) LEF-11 could be transported into the nucleus during viral infection in the absence of a cNLSs. Further investigations demonstrated that the NLS of BmNPV LEF-11 is important for viral DNA replication. The findings of the present study indicate that the characteristics of the baculovirus LEF-11 protein and the NLS is essential to virus DNA replication and nuclear transport mechanisms. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. V390 Nor = Nova Normae 2007

    NASA Astrophysics Data System (ADS)

    Waagen, Elizabeth O.

    2007-06-01

    Nova Normae 2007 was discovered photographically by William Liller on June 15.086 UT at magnitude 9.4. Precise position measured by G. Bolt from his unfiltered CCD image of June 16.7 UT: 16:32:11.51 -45:09:13.4 (2000.0). Giorgio Di Scala reported to the AAVSO that a low-resolution spectrum indicates a nova a week or so after outburst, with strong H-alpha emission. E. Kazarovets, Sternberg Astronomical Institute, reports that N Nor 07 has been assigned the name V390 Nor. Discovery originally announced in IAU Central Bureau Electronic Telegram 982 (Daniel W. E. Green) and AAVSO Special Notice #49 (Arne Henden). Information in this Alert Notice was received at AAVSO from William Liller, Giorgio Di Scala, or via IAU Circular No. 8850, ed. Daniel W. E. Green. A chart for V390 Nor is available via the Variable Star Plotter (VSP). Go to: http://www.aavso.org/observing/charts/vsp/ and enter the name V390 NOR.

  18. 11. Interior view of control room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Interior view of control room in Components Test Laboratory (T-27), looking north. Photograph shows upgraded instrumentation, piping, and technological modifications installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  19. Assisted stellar suicide in V617 Sagittarii

    NASA Astrophysics Data System (ADS)

    Steiner, J. E.; Oliveira, A. S.; Cieslinski, D.; Ricci, T. V.

    2006-02-01

    Context: .V617 Sgr is a V Sagittae star - a group of binaries thought to be the galactic counterparts of the Compact Binary Supersoft X-ray Sources - CBSS. Aims: .To check this hypothesis, we measured the time derivative of its orbital period. Methods: .Observed timings of eclipse minima spanning over 30 000 orbital cycles are presented. Results: .We found that the orbital period evolves quite rapidly: P/dot{P} = 1.1×106 years. This is consistent with the idea that V617 Sgr is a wind driven accretion supersoft source. As the binary system evolves with a time-scale of about one million years, which is extremely short for a low mass evolved binary, it is likely that the system will soon end either by having its secondary completely evaporated or by the primary exploding as a supernova of type Ia. Conclusions: .

  20. Apollo 11 Lunar Message For Mankind

    NASA Technical Reports Server (NTRS)

    1959-01-01

    Millions of people on Earth watched via television as a message for all mankind was delivered to the Mare Tranquilitatis (Sea of Tranquility) region of the Moon during the historic Apollo 11 mission, where it still remains today. This commemorative plaque, attached to the leg of the Lunar Module (LM), Eagle, is engraved with the following words: 'Here men from the planet Earth first set foot upon the Moon July, 1969 A.D. We came in peace for all of mankind.' It bears the signatures of the Apollo 11 astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin, Jr., Lunar Module (LM) pilot along with the signature of the U.S. President Richard M. Nixon. The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  1. Apollo 11 Lunar Message For Mankind

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Millions of people on Earth watched via television as a message for all mankind was delivered to the Mare Tranquilitatis (Sea of Tranquility) region of the Moon during the historic Apollo 11 mission, where it still remains today. A technician holds the commemorative plaque that was later attached to the leg of the Lunar Module (LM), Eagle, engraved with the following words: 'Here men from the planet Earth first set foot upon the Moon July, 1969 A.D. We came in peace for all of mankind.' It bears the signatures of the Apollo 11 astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin, Jr., Lunar Module (LM) pilot along with the signature of the U.S. President Richard M. Nixon. The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  2. Quarantined Apollo 11 Astronauts Addressed by U.S. President Nixon

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted by helicopter and taken to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF). Shown here are the Apollo 11 crew members (L to R) Neil Armstrong, Michael Collins, and Edwin Aldrin inside the MQF as U.S. President Richard Milhous Nixon speaks to them via intercom. The president was aboard the recovery vessel awaiting return of the astronauts. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  3. Electroproduction of {eta} mesons in the S{sub 11} (1535) resonance region at high momentum transfer.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dalton, M. M.; Adams, G. S.; Ahmidouch, A.

    2009-07-01

    The differential cross section for the process p(e,e{prime}p) {eta} has been measured at Q{sup 2} {approx} 5.7 and 7.0(GeV/c){sup 2} for center-of-mass energies from threshold to 1.8 GeV, encompassing the S{sub 11}(1535) resonance, which dominates the channel. This is the highest momentum-transfer measurement of this exclusive process to date. The helicity-conserving transition amplitude A{sub 1/2}, for the production of the S{sub 11}(1535) resonance, is extracted from the data. Within the limited Q{sup 2} now measured, this quantity appears to begin scaling as Q{sup -3} - a predicted, but not definitive, signal of the dominance of perturbative QCD at Q{sup 2}more » {approx} 5 (GeV/c){sup 2}.« less

  4. Influence of organic ions on DNA damage induced by 1 eV to 60 keV electrons.

    PubMed

    Zheng, Yi; Sanche, Léon

    2010-10-21

    We report the results of a study on the influence of organic salts on the induction of single strand breaks (SSBs) and double strand breaks (DSBs) in DNA by electrons of 1 eV to 60 keV. Plasmid DNA films are prepared with two different concentrations of organic salts, by varying the amount of the TE buffer (Tris-HCl and EDTA) in the films with ratio of 1:1 and 6:1 Tris ions to DNA nucleotide. The films are bombarded with electrons of 1, 10, 100, and 60 000 eV under vacuum. The damage to the 3197 base-pair plasmid is analyzed ex vacuo by agarose gel electrophoresis. The highest yields are reached at 100 eV and the lowest ones at 60 keV. The ratios of SSB to DSB are surprisingly low at 10 eV (∼4.3) at both salt concentrations, and comparable to the ratios measured with 100 eV electrons. At all characteristic electron energies, the yields of SSB and DSB are found to be higher for the DNA having the lowest salt concentration. However, the organic salts are more efficient at protecting DNA against the damage induced by 1 and 10 eV electrons. DNA damage and protection by organic ions are discussed in terms of mechanisms operative at each electron energy. It is suggested that these ions create additional electric fields within the groove of DNA, which modify the resonance parameter of 1 and 10 eV electrons, namely, by reducing the electron capture cross-section of basic DNA units and the lifetime of corresponding transient anions. An interstrand electron transfer mechanism is proposed to explain the low ratios for the yields of SSB to those of DSB produced by 10 eV electrons.

  5. Influence of organic ions on DNA damage induced by 1 eV to 60 keV electrons

    PubMed Central

    Zheng, Yi; Sanche, Léon

    2011-01-01

    We report the results of a study on the influence of organic salts on the induction of single strand breaks (SSBs) and double strand breaks (DSBs) in DNA by electrons of 1 eV to 60 keV. Plasmid DNA films are prepared with two different concentrations of organic salts, by varying the amount of the TE buffer (Tris-HCl and EDTA) in the films with ratio of 1:1 and 6:1 Tris ions to DNA nucleotide. The films are bombarded with electrons of 1, 10, 100, and 60 000 eV under vacuum. The damage to the 3197 base-pair plasmid is analyzed ex vacuo by agarose gel electrophoresis. The highest yields are reached at 100 eV and the lowest ones at 60 keV. The ratios of SSB to DSB are surprisingly low at 10 eV (~4.3) at both salt concentrations, and comparable to the ratios measured with 100 eV electrons. At all characteristic electron energies, the yields of SSB and DSB are found to be higher for the DNA having the lowest salt concentration. However, the organic salts are more efficient at protecting DNA against the damage induced by 1 and 10 eV electrons. DNA damage and protection by organic ions are discussed in terms of mechanisms operative at each electron energy. It is suggested that these ions create additional electric fields within the groove of DNA, which modify the resonance parameter of 1 and 10 eV electrons, namely, by reducing the electron capture cross-section of basic DNA units and the lifetime of corresponding transient anions. An interstrand electron transfer mechanism is proposed to explain the low ratios for the yields of SSB to those of DSB produced by 10 eV electrons. PMID:20969428

  6. Moon Rock Presented to Smithsonian Institute by Apollo 11 Crew

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Apollo 11 astronauts, (left to right) Edwin E. Aldrin Jr., Lunar Module pilot; Michael Collins, Command Module pilot; and Neil A. Armstrong, commander, are showing a two-pound Moon rock to Frank Taylor, director of the Smithsonian Institute in Washington D.C. The rock was picked up from the Moon's surface during the Extra Vehicular Activity (EVA) of Aldrin and Armstrong following man's first Moon landing and was was presented to the Institute for display in the Art and Industries Building. The Apollo 11 mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  7. A novel homozygous mutation IVS6+5G>T in CYP11B1 gene in a Vietnamese patient with 11β-hydroxylase deficiency.

    PubMed

    Nguyen, Thi Phuong Mai; Nguyen, Thu Hien; Ngo, Diem Ngoc; Vu, Chi Dung; Nguyen, Thi Kim Lien; Nong, Van Hai; Nguyen, Huy Hoang

    2015-07-10

    Congenital adrenal hyperplasia (CAH) is an autosomal recessive disease which is characterized by a deficiency of one of the enzymes involved in the synthesis of cortisol from cholesterol by the adrenal cortex. CAH cases arising from impaired 11β-hydroxylase are the second most common form. Mutations in the CYP11B1 gene are the cause of 11β-hydroxylase deficiency. This study was performed on a patient with congenital adrenal hyperplasia and with premature development such as enlarged penis, muscle development, high blood pressure, and bone age equivalent of 5 years old at 2 years of chronological age. Biochemical tests for steroids confirmed the diagnosis of CAH. We used PCR and sequencing to screen for mutations in CYP11B1 gene. Results showed that the patient has a novel homozygous mutation of guanine (G) to thymine (T) in intron 6 (IVS6+5G>T). The analysis of this mutation by MaxEntScan boundary software indicated that this mutant could affect the gene splicing during transcription. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. STATS SRS v11.0

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Piscotty, M A; Nazario, O L

    2007-06-20

    The objective of this project is the delivery of an application that will provide a unified, web-based system for collecting, verifying and analyzing the achievements for Laboratory employees. The application will enable individual Directorates to manage and report achievement record data for their employees using an LLNL standard web browser. In addition, cross directorate data reporting and analysis will be available for such organizations as LSTO and programmatic directorates. This system is intended to store reference data and metadata for employee achievements. Abstracts and entire publications will not be stored in this system.Directorates are expected to use this system atmore » all levels of management in preparing for Annual Self-Assessments, peer reviews, LDRD reviews, work force reviews, performance appraisals, and requests from sponsors. This document represents the primary deliverable for the Requirements Definition stage of system development. As part of a successful Requirements Definition, this document provides the development staff, the project sponsor, and the user community with a clear understanding of the product's operational, data, and other requirements. With this understanding, the development staff will take the opportunity to refine estimates regarding the cost, schedule, and deliverables reflected in it.« less

  9. How Informative Are Self-Reported Adult Attention-Deficit/Hyperactivity Disorder Symptoms? An Examination of the Agreement Between the Adult Attention-Deficit/Hyperactivity Disorder Self-Report Scale V1.1 and Adult Attention-Deficit/Hyperactivity Disorder Investigator Symptom Rating Scale.

    PubMed

    Silverstein, Michael J; Faraone, Stephen V; Alperin, Samuel; Biederman, Joseph; Spencer, Thomas J; Adler, Lenard A

    2018-06-01

    Assess agreement between self-ratings via the adult attention-deficit/hyperactivity disorder (ADHD) Self-Report Scale (ASRS)-v1.1 Symptom Checklist and clinician ratings via the adult ADHD Investigator Symptom Rating Scale (AISRS) expanded version using DSM-5 adult ADHD patients (referred sample) and ADHD controls (recruited from a primary care physician practice). The ASRS v1.1 Symptom Checklist was administered to measure self-reported ADHD symptoms and impairment, the Adult ADHD Clinical Diagnostic Scale v1.2 was used to establish an adult ADHD diagnosis and the childhood and adult/current sections of the scale were used to provide scores to measure symptoms of childhood ADHD and recent symptoms of adult ADHD, the AISRS to measure ADHD current symptom severity. Participants (n = 299; range 18-58), of which 171 were ADHD+ and 128 ADHD-. ASRS and AISRS total scores and individual subsections examining inattention, hyperactivity, emotional dysfunction (EF), and emotional dyscontrol (EC) were all significantly correlated (Spearman's ρ's = 0.78-0.89, ps < 0.01). Correlations remained significant when controlling for demographic factors and psychiatric conditions. The ASRS (self) and AISRS (clinician rated) scales have high agreement. This agreement extended not only the to the core 18 DSM symptoms, but also to the additional 13 symptoms that examine EC and EF.

  10. A 1.37-Mb 12p11.22-p11.21 deletion coincident with a 367-kb 22q11.2 duplication detected by array comparative genomic hybridization in an adolescent girl with autism and difficulty in self-care of menstruation.

    PubMed

    Chen, Chih-Ping; Lin, Shuan-Pei; Chern, Schu-Rern; Wu, Peih-Shan; Su, Jun-Wei; Lee, Chen-Chi; Wang, Wayseen

    2014-03-01

    To present an array comparative genomic hybridization (aCGH) characterization of a 12p11.22-p11.21 microdeletion and 22q11.2 microduplication in an adolescent girl with autism, mental retardation, facial dysmorphism, microcephaly, behavior problems, and an apparently balanced reciprocal translocation of t(8;12)(q24.3;p11.2). A 13-year-old girl was referred to the hospital because of autism, mental retardation, and difficulty in the self-care of her menstruation. Cytogenetic analysis revealed an apparently balanced reciprocal translocation and a karyotype of 46,XX,t(8;12) (q24.3;p11.2)dn. The girl manifested microcephaly, hypertelorism, flat facial profile, prominent forehead, thick scalp hair, upslanting palpebral fissures, broad nasal bridge, bulbous nose, right simian crease, bilateral clinodactyly of the fifth fingers, bilateral pes cavus, learning difficulties, mental retardation, emotional instability, cognitive impairment, behavior problems, jumping-like gaits, and autistic spectrum disorder. aCGH was performed to evaluate genomic imbalance in this patient. aCGH analysis revealed a 1.37-Mb 12p11.22-p11.21 microdeletion or arr [hg 19] 12p11.22-p11.21 (30,645,008-32,014,774)×1 and a 367-kb 22q11.21 microduplication or arr [hg 19] 22q11.21 (18,657,470-19,024,306)×3. The 1.37-Mb 12p11.22-p11.21 microdeletion encompassed 26 genes including IPO8, CAPRIN2, and DDX11, and the 367-kb 22q11.21 microduplication encompassed 20 genes including USP18, DGCR6, PRODH, and DGCR2. An apparently balanced translocation may be in fact affected by concurrent deletion and duplication in two different chromosomal regions. Our presentation provides information on diagnostic phenotype of 12p11.22-p11.21 microdeletion and 22q11.2 microduplication. Copyright © 2014. Published by Elsevier B.V.

  11. V&V framework

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hills, Richard G.; Maniaci, David Charles; Naughton, Jonathan W.

    2015-09-01

    A Verification and Validation (V&V) framework is presented for the development and execution of coordinated modeling and experimental program s to assess the predictive capability of computational models of complex systems through focused, well structured, and formal processes.The elements of the framework are based on established V&V methodology developed by various organizations including the Department of Energy, National Aeronautics and Space Administration, the American Institute of Aeronautics and Astronautics, and the American Society of Mechanical Engineers. Four main topics are addressed: 1) Program planning based on expert elicitation of the modeling physics requirements, 2) experimental design for model assessment, 3)more » uncertainty quantification for experimental observations and computational model simulations, and 4) assessment of the model predictive capability. The audience for this document includes program planners, modelers, experimentalist, V &V specialist, and customers of the modeling results.« less

  12. Word Frequency Analysis. MOS: 26Q. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    L! 2 9 Ll- 236 t /G 2 Pi 2 3’,F/G z PU-332jS/l Z z *.I PjkPig5E 2 P :3 IZ/’ 2 wA I A 1i 2 QvA 1 . T ITy 2 .3il.-rss 2 RTZEIVEC Z .F, 11~ k 11:8E R 2 K...ADA0?U ARMY TRAINING DEVELOPMENTS INST FORT MONdROE VA /5/ADWORD FREQUENCY ANALYSIS. MOSI 24. SKILL LEVELS 1 6 2.1U) / MAY 81 A A LONGO UNCLASSIFIED...1qR1 ATTN: ATTG;-DOR 13. NUQBER OF PAGES 14 OIOMlGAEC AEaAOESI dilt.,,.l 1 - ContIrMA OfII..) 15. SECURITY CLASS. fo1 VdI. ftw.f) Unclassified 150

  13. Electroproduction of η Mesons in the S 11(1535) Resonance Region at High Momentum Transfer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dalton, Mark Macrae

    2008-08-01

    The differential cross-section for the exclusive process p(e, e0p) has been measured at Q 2 5.7 and 7.0 (GeV/c) 2, which represents the highest momentum transfer measurement of this to date, significantly higher than the previous highest at Q 2 3.6 (GeV/c) 2. Data was taken for centre-of-mass energies from threshold to 1.8 GeV, encompassing the S11(1535) resonance, which dominates the pη channel. The total cross section is obtained, from which is extracted the helicity-conserving transition amplitude A 1/2, for the production of the S11(1535) resonance. This quantity appears to begin scaling as Q -3, a predicted signal of themore » dominance of perturbative QCD, within the Q 2 range of this measurement. No currently available theoretical predictions can account for the behaviour of this quantity over the full measured range of Q 2.« less

  14. 4-Valent Human Papillomavirus (4vHPV) Vaccine in Preadolescents and Adolescents After 10 Years.

    PubMed

    Ferris, Daron G; Samakoses, Rudiwilai; Block, Stanley L; Lazcano-Ponce, Eduardo; Restrepo, Jaime Alberto; Mehlsen, Jesper; Chatterjee, Archana; Iversen, Ole-Erik; Joshi, Amita; Chu, Jian-Li; Krick, Andrea Likos; Saah, Alfred; Das, Rituparna

    2017-12-01

    We describe the final 10-year data for the long-term follow-up study of the 4-valent human papillomavirus (4vHPV) vaccine in preadolescents and adolescents. In the base study (V501-018), 1661 sexually inactive boys and girls received the 4vHPV vaccine (early vaccination group [EVG], managed for 9.9 years) or a placebo at day 1, month 2, and month 6. Thereafter, at month 30, the placebo group (catch-up vaccination group [CVG], managed for 7.4 years) received the 4vHPV vaccine by using the same dosing schedule. Long-term anti-HPV type 6, 11, 16, and 18 immune responses were assessed. Effectiveness was estimated by calculating the incidence rate of the primary endpoints (HPV types 6, 11, 16, and 18-related disease or persistent infection). For HPV types 6, 11, and 16, 89% to 96% of subjects remained seropositive through 10-years postvaccination. The preadolescents had 38% to 65% higher geometric mean titers at month 7, which remained 16% to 42% higher at 10 years compared with adolescents. No cases of HPV type 6, 11, 16, and 18-related diseases were observed. Ten subjects had a persistent infection of ≥6 months duration with vaccine-type HPV and 2 subjects had persistent infection for ≥12 months. No new serious adverse events were reported through 10 years. A 3-dose regimen of the 4vHPV vaccine was immunogenic, clinically effective, and generally well tolerated in preadolescents and adolescents during 10 years of follow-up. These long-term findings support efforts to vaccinate this population against HPV before exposure. Copyright © 2017 by the American Academy of Pediatrics.

  15. Neil Armstrong gets round of applaus at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong stands to a round of applause after being introduced at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

  16. Comparison of halo of 11Be, 15C, and 19C

    NASA Astrophysics Data System (ADS)

    Kharab, R.; Kumar, R.; Singh, P.; Sharma, H. C.

    2007-12-01

    We have compared the halo of 11Be, 15C, and 19C nuclei by analyzing the one-neutron stripping reaction data on the Be target at 60-, 54-, and 57-MeV/ A beam energies, respectively, within the framework of the eikonal approximation approach. The determination of effective range through the comparison of the total cross section data and prediction has revealed that the halo of 19C is the well developed, while that of 15C is the least and that of 11Be lies in between these two. The longitudinal momentum distribution data also strengthen these observations.

  17. de Haas–van Alphen study of role of 4 f electrons in antiferromagnetic CeZn 11 as compared to its nonmagnetic analog LaZn 11

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blake, S. F.; Hodovanets, H.; McCollam, A.

    Here we present a de Haas–van Alphen study of the Fermi surface of the low-temperature antiferromagnet CeZn 11 and its nonmagnetic analog LaZn 11, measured by torque magnetometry up to fields of 33T and at temperatures down to 320 mK . Both systems possess similar de Haas–van Alphen frequencies, with three clear sets of features—ranging from 50 T to 4 kT —corresponding to three bands of a complex Fermi surface, with an expected fourth band also seen weakly in CeZn 11 . The effective masses of the charge carriers are very light (<1 m e) in LaZn 11 but amore » factor of 2–4 larger in CeZn 11, indicative of stronger electronic correlations. We perform detailed density functional theory (DFT) calculations for CeZn 11 and find that only DFT+ U calculations with U = 1.5 eV , which localize the 4 f states, provide a good match to the measured de Haas–van Alphen frequencies, once the presence of magnetic breakdown orbits is also considered. Finally, our study suggests that the Fermi surface of CeZn 11 is very close to that of LaZn 11 being dominated by Zn 3d , as the Ce 4 f states are localized and have little influence on its electronic structure, however, they are responsible for its magnetic order and contribute to enhance electronic correlations.« less

  18. de Haas–van Alphen study of role of 4 f electrons in antiferromagnetic CeZn 11 as compared to its nonmagnetic analog LaZn 11

    DOE PAGES

    Blake, S. F.; Hodovanets, H.; McCollam, A.; ...

    2016-12-02

    Here we present a de Haas–van Alphen study of the Fermi surface of the low-temperature antiferromagnet CeZn 11 and its nonmagnetic analog LaZn 11, measured by torque magnetometry up to fields of 33T and at temperatures down to 320 mK . Both systems possess similar de Haas–van Alphen frequencies, with three clear sets of features—ranging from 50 T to 4 kT —corresponding to three bands of a complex Fermi surface, with an expected fourth band also seen weakly in CeZn 11 . The effective masses of the charge carriers are very light (<1 m e) in LaZn 11 but amore » factor of 2–4 larger in CeZn 11, indicative of stronger electronic correlations. We perform detailed density functional theory (DFT) calculations for CeZn 11 and find that only DFT+ U calculations with U = 1.5 eV , which localize the 4 f states, provide a good match to the measured de Haas–van Alphen frequencies, once the presence of magnetic breakdown orbits is also considered. Finally, our study suggests that the Fermi surface of CeZn 11 is very close to that of LaZn 11 being dominated by Zn 3d , as the Ce 4 f states are localized and have little influence on its electronic structure, however, they are responsible for its magnetic order and contribute to enhance electronic correlations.« less

  19. High P/V ratio of GaInAs/InP resonant tunneling diode grown by OMVPE

    NASA Astrophysics Data System (ADS)

    Sekiguchi, Tomonori; Miyamoto, Yasuyuki; Furuya, Kazuhito

    1992-11-01

    This paper reports higher peak-to-valley current (P/V) ratio in GaInAs/InP resonant tunneling diode (RTD) than ever. In organomettalic vapor phase epitaxy, the P/V ratio depends strongly on the partial pressure of the group V gas. The obtained P/V ratios are 9.7 and 7.4 at 4 and 77 K, respectively. The width of the resonance level is 11 meV at 4 K.

  20. Sex and age differences in attention-deficit/hyperactivity disorder symptoms and diagnoses: implications for DSM-V and ICD-11.

    PubMed

    Ramtekkar, Ujjwal P; Reiersen, Angela M; Todorov, Alexandre A; Todd, Richard D

    2010-03-01

    To examine gender and age differences in attention-deficit/hyperactivity disorder (ADHD) symptom endorsement in a large community-based sample. Families with four or more full siblings ascertained from Missouri birth records completed telephone interviews regarding lifetime DSM-IV ADHD symptoms and the Strengths and Weaknesses of ADHD-Symptoms and Normal-behavior (SWAN) questionnaire for current ADHD symptoms. Complete data were available for 9,380 subjects aged 7 through 29 years. Lifetime and current DSM-IV-like ADHD diagnoses were assigned by the DSM-IV symptom criteria. Linear regression was used to examine sex and age effects on SWAN ADHD symptom scores. Logistic regression was used to examine sex and age effects on specific ADHD diagnoses. Fractional polynomial graphs were used to examine ADHD symptom count variations across age. Overall prevalence of current DSM-IV-like ADHD was 9.2% with a male:female ratio of 2.28:1. The prevalence of DSM-IV-like ADHD was highest in children. Gender differences in DSM-IV-like ADHD subtype prevalences were highest in adolescents. On average, individuals with lifetime DSM-IV-like ADHD diagnoses had elevated current ADHD symptoms even as adolescents or adults. Lower male:female ratios than reported in some clinic-based studies suggest that females are underdiagnosed in the community. Although they may no longer meet the full symptom criteria, young adults with a history of lifetime DSM-IV-like ADHD maintain higher levels of ADHD symptoms compared with the general population. The use of age-specific diagnostic criteria should be considered for DSM-V and ICD-11.

  1. Measurements of Reaction Cross Sections for 9-11C

    NASA Astrophysics Data System (ADS)

    Nishizuka, Kenji; Takechi, Maya; Ohtsubo, Takashi; Nishimura, Daiki; Fukuda, Mitsunori; Aoki, Kazuya; Abe, Keijiro; Ikeda, Ayaka; Izumikawa, Takuji; Oikawa, Hiroyuki; Ohnishi, Kosuke; Ohno, Junichi; Ohmika, Shunichiro; Kato, Ikuma; Kanke, Yuki; Kanbe, Shunsuke; Kanda, Naoto; Kikuchi, Haruka; Kitagawa, Atsushi; Sato, Shinji; Sayama, Umito; Shimaya, Jiro; Sugihara, Takanobu; Suzuki, Shinji; Suzuki, Takeshi; Takahashi, Hiroki; Taguchi, Yoshisada; Takei, Yuki; Takeuchi, Yuki; Takenouchi, Arashi; Takemoto, Takanori; Tadano, Natsuki; Tanaka, Masaomi; Tanaka, Yutaro; Chikaato, Kazuya; Du, Hang; Nagai, Takumi; Nagumo, Junya; Fukuda, Shigekazu; Hori, Kensyu; Honma, Akira; Machida, Masahiro; Matsunaga, Satoshi; Mizukami, Atsushi; Mihara, Mototsugu; Miyata, Eri; Murooka, Daiki; Yagi, Shoichi; Yamaoka, Shintaro; Yamaguchi, Takayuki; Yokoyama, Kouhei

    In order to probe the differences of matter and charge radii of atomic nucleus in the proton-rich C isotopes, measurements of reaction cross sections (σR) for 9-11C on proton targets in the energy range from 50 to 120A MeV were performed at HIMAC facility, NIRS. Owing to the large differences between proton-proton and proton-neutron scattering cross sections at this intermediate energy region, σR data for atomic nuclei on proton targets are expected to have the sensitivity to the differences between proton and neutron distributions in the nucleus. Present preliminary data are compared with the Glauber calculation, which suggest the larger enhancements of proton distributions in 9C and 10C compared to 11C.

  2. High-speed multicolor photometry of V834 Centaurus

    NASA Technical Reports Server (NTRS)

    Middleditch, John; Imamura, James N.; Wolff, Michael T.; Steiman-Cameron, Thomas Y.

    1991-01-01

    Results are presented of high-speed photometric observations of the Am Her object, V834 Centaurus which, during its high state, revealed the 0.3-0.9 Hz quasi-period oscillations (QPOs) with rms amplitudes of 3.3 +/-1.1 percent and 2.5 +/-0.8 percent in the V and R bands, respectively, while the U-band amplitude was consistent with zero on one night but was 2.5 +/-1.2 percent on the following night. The QPOs in the B band were always consistent with zero. The data were obtained on the nights of June 16-21, 1990, when the average V magnitude of V834 Cen was about 15.3, confirming the high-luminosity state. The dominance of the QPOs by V-band emission is in contrast to earlier studies by Larsson which found that the QPOs were dominated by emission in the B and R band, depending upon the luminosity state of V834 Cen. In all cases, the QPOs of V834 have frequencies of 0.3-0.9 Hz. It is inferred that the color of the QPOs could be highly variable between luminosity states and may be variable in the U band within the high-luminosity state.

  3. State selected ion--molecule reactions by a TESICO technique. V. N/sub 2//sup +/(v)+Ar. -->. N/sub 2/+Ar/sup +/

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kato, T.; Tanaka, K.; Koyano, I.

    1982-07-15

    Charge transfer reactions N/sub 2//sup +/(v)+Ar..-->..Ar/sup +/+N/sub 2/ (1) have been studied by selecting the vibrational states of N/sub 2//sup +/ using the threshold electron--secondary ion coincidence (TESICO) technique. Relative cross sections sigma(v) for the individual vibrational states v = 0--3 have been determined at three collision energies, 0.3, 1.5, and 11.8 eV. Results show that Reaction (1), which is endoergic for v = 0, is considerably enhanced by the vibrational excitation of N/sub 2//sup +/ at all collision energies. While excitation of one vibrational quantum enhances the cross section substantially, excitation of additional quanta further increases the cross sectionmore » up to v = 3. The ratios sigma(2)/sigma(1) and sigma(3)/sigma(2) are, however, much smaller than sigma(1)/sigma(0) and are significantly larger at the highest collision energy than at the other two collision energies. These results are discussed in conjunction with the calculated results based on the simple two-state theory of Rapp and Francis and the Franck--Condon factors.« less

  4. 40 CFR 721.10420 - Fluoropolymers (generic) (P-11-567, P-11-568, and P-11-569).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Fluoropolymers (generic) (P-11-567, P-11-568, and P-11-569). 721.10420 Section 721.10420 Protection of Environment ENVIRONMENTAL PROTECTION... New Uses for Specific Chemical Substances § 721.10420 Fluoropolymers (generic) (P-11-567, P-11-568...

  5. 40 CFR 721.10420 - Fluoropolymers (generic) (P-11-567, P-11-568, and P-11-569).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Fluoropolymers (generic) (P-11-567, P-11-568, and P-11-569). 721.10420 Section 721.10420 Protection of Environment ENVIRONMENTAL PROTECTION... New Uses for Specific Chemical Substances § 721.10420 Fluoropolymers (generic) (P-11-567, P-11-568...

  6. 40 CFR 721.10420 - Fluoropolymers (generic) (P-11-567, P-11-568, and P-11-569).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Fluoropolymers (generic) (P-11-567, P-11-568, and P-11-569). 721.10420 Section 721.10420 Protection of Environment ENVIRONMENTAL PROTECTION... New Uses for Specific Chemical Substances § 721.10420 Fluoropolymers (generic) (P-11-567, P-11-568...

  7. Persistent monoclonality after histological remission in gastric mucosa-associated lymphoid tissue lymphoma treated with chemotherapy and/or surgery: influence of t(11;18)(q21;q21).

    PubMed

    Santón, Almudena; García-Cosio, Mónica; Bellosillo, Beatriz; Rodríguez, Patricia; Cristóbal, Eva; Serrano, Sergio; Besses, Carlos; Abraira, Victor; Salar, Antonio; Montalbán, Carlos

    2008-08-01

    The purpose of this work was to study retrospectively the molecular response and outcome of 19 gastric mucosa associated lymphoid tissue (MALT) lymphoma patients achieving histological remission after chemotherapy or surgery. Immunoglobulin heavy chain variable (IgV(H)) gene rearrangements were studied by PCR in biopsies obtained at diagnosis and follow-up. Presence of t(11;18)(q21;q21) was studied by FISH or RT-PCR. Sequencing analysis of three t(11;18)(q21;q21) positive and two negative lymphomas with persistent monoclonal IgV(H) rearrangements was also performed. Long-term IgV(H) monoclonality was demonstrated in 11/19 patients (58%); in five of them monoclonal rearrangements were present in all samples throughout the follow-up. Persistent IgV(H) monoclonality was detected a median of 49 months after the achievement of histological response and did not condition histological relapse in most cases. All three t(11;18)(q21;q21) positive patients had maintained IgV(H) monoclonality and sequencing analyses revealed the same mutated IgV(H) alleles in the diagnostic and the follow-up samples. Over half of the patients with gastric MALT lymphoma with histological response after chemotherapy and/or surgery have long-term persistent monoclonality. The presence of t(11;18)(q21;q21) seems to condition long-term persistence of the initial lymphoma clone.trade mark.

  8. Analysis of Superconducting Dipole Coil of 11 GeV Super High Momentum Spectrometer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sun, Eric; Cheng, Gary; Lassiter, Steve R.

    2015-06-01

    Jefferson Lab is constructing five Super High Momentum Spectrometer (SHMS) superconducting magnets for the 12 GeV Upgrade. This paper reports measured coil material properties and the results of the extensive finite element analysis (FEA) for the dipole coil. To properly define the smeared orthotropic material of the coil, a detailed coil model is set up to compute material parameters because not all parameters were measured. Stress and strain acceptance criteria are discussed. Eight load steps are defined. The preheat temperature of the force collar is optimized under two loading scenarios so that the positive pressure between the inner coil andmore » central spacer is maintained while there is not too much squeeze to the coil.« less

  9. The 10B(p,α)7Be S(E)-factor from 5 keV to 1.5 MeV using the Trojan Horse Method

    NASA Astrophysics Data System (ADS)

    Puglia, Sebastiana Maria Regina; Spitaleri, Claudio; La Cognata, Marco; Lamia, Livio; Broggini, Carlo; Caciolli, Antonio; Carlin, Nelson; Cherubini, Silvio; Cvetinovic, Alexandra; D'Agata, Giuseppe; Dell'aquila, Daniele; Depalo, Rosanna; Gulino, Marisa; Guardo, Giovanni Luca; Indelicato, Iolanda; Lombardo, Ivano; Menegazzo, Roberto; Munhoz, Marcelo Gimenez; Pizzone, Rosario Gianluca; Rapisarda, Giuseppe Gabriele; Rigato, Valentino; Romano, Stefano; Sergi, Maria Letizia; Souza, Francisco; Sparta, Roberta; Tudisco, Salvo; Tumino, Aurora

    2018-01-01

    The 10B(p,α)7Be reaction is the main responsible for the 10B destruction in stellar interior [1]. In such environments this p-capture process occurs at a Gamow energy of 10 keV and takes places mainly through a resonant state (Ex = 8.701 MeV) of the compound 11C nucleus. Thus a resonance right in the region of the Gamow peak is expected to significantly influence the behavior of the astrophysical S(E)-factor. The 10B(p,α)7Be reaction was studied via the Trojan Horse Method (THM) applied to the 2H(10B,α7Be)n in order to extract the astrophysical S(E)-factor in a wide energy range from 5 keV to 1.5 MeV.

  10. Timing of the onset of MIS 11 revealed by speleothem in southern Europe

    NASA Astrophysics Data System (ADS)

    Hu, Hsun-Ming; Shen, Chuan-Chou; Michel, Véronique; Kano, Akihiro

    2017-04-01

    The interglacial period, known as Marine Isotope Stage 11 (MIS 11, 428-397 thousand years ago), is often considered as a potential analogue for future climate projection because of the similar patterns of insolation variability. However, studies on mechanisms of the onset of MIS 11 (called Termination V, T-V) in response to insolation increase is still hampered by a lack of good dating materials in paleoclimate archives, despite a stack of East Asian monsoon records with precise U-Th dates has been proposed. Previous studies suggested the δ18O value registered in speleothems in Mediterranean realm can be a good bridge connecting the U-Th-based age model of speleothem to marine cores from Mediterranean sea, which opens a new possibility to detect ocean-atmosphere/internal-external forcing interaction beyond 14C dating limitation. Here we present a new speleothem δ18O record from northern Italy covering 500-300 thousand years ago. The results show a similar pattern with δ18O records of marine cores around Mediterranean. The age model of the speleothem hence provides an opportunity for tuning the marine cores, which could improve our understanding of relationship between global atmosphere and ocean circulations.

  11. Radiation Effects in III-V Nanowire Devices

    DTIC Science & Technology

    2016-09-01

    Nanowire Devices Distribution Statement A. Approved for public release; distribution is unlimited. September 2016 HDTRA1-11-1-0021 Steven R...Name: Prof. S. R. J. Brueck Organization/Institution: University of New Mexico Project Title: Radiation Effects in III-V Nanowire Devices What are...the agency approved application or plan. The objectives of this program were to: a) develop a new nanowire transistor technology based on nanoscale

  12. Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers

    PubMed Central

    Haylock, Anna-Karin; Nilvebrant, Johan; Mortensen, Anja; Velikyan, Irina; Nestor, Marika; Falk, Ronny

    2017-01-01

    Aim The aim of this study was to generate and characterize scFv antibodies directed to human CD44v6, as well as to radiolabel and evaluate top candidates in vitro and in vivo for their potential use in CD44v6-targeted molecular imaging in cancer patients. Materials and methods Phage display selections were used to isolate CD44v6-specific scFvs. A chain shuffling strategy was employed for affinity maturation based on a set of CD44v6-specific first-generation clones. Two second-generation scFv clones were then chosen for labeling with 111In or 125I and assessed for CD44v6-specific binding on cultured tumor cells. In vivo uptake and distribution was evaluated in tumor-bearing mice using a dual tumor model. Finally, a proof-of-concept small animal PET-CT study was performed on one of the candidates labeled with 124I. Results Two affinity-matured clones, CD44v6-scFv-A11 and CD44v6-scFv-H12, displayed promising binding kinetics. Seven out of eight radiolabeled conjugates demonstrated CD44v6-specific binding. In vivo studies on selected candidates demonstrated very advantageous tumor-to-organ ratios, in particular for iodinated conjugates, where 125I-labeled scFvs exhibited favorable kinetics and tumor-to-blood ratios above five already at 24 hours p.i.. The small animal PET-CT study using 124I-labeled CD44v6-scFv-H12 was in line with the biodistribution data, clearly visualizing the high CD44v6-expressing tumor. Conclusion The single chain fragments, CD44v6-scFv-A11 and CD44v6-scFv-H12 specifically bind to CD44v6, and the radiolabeled counterparts provide high tumor-to-blood ratios and fast clearance from organs and blood. We conclude that radioiodinated CD44v6-scFv-A11 and CD44v6-scFv-H12 possess features highly suitable for stringent molecular imaging. PMID:29029420

  13. Apollo 11 Lunar Message For Mankind

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Millions of people on Earth watched via television as a message for all mankind was delivered to the Mare Tranquilitatis (Sea of Tranquility) region of the Moon during the historic Apollo 11 mission, where it still remains today. A commemorative plaque was attached to the leg of the Lunar Module (LM), Eagle, engraved with the following words: 'Here men from the planet Earth first set foot upon the Moon July, 1969 A.D. We came in peace for all of mankind.' It bears the signatures of the Apollo 11 astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin, Jr., Lunar Module (LM) pilot along with the signature of the U.S. President Richard M. Nixon. The plaque, as shown here, covered with protective steel for the launch and journey to the moon, was uncovered by crew members after landing. The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  14. Dielectron Azimuthal Anisotropy at mid-rapidity in Au+Au collisions at root s=200GeV

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adamczyk, L.

    We report on the first measurement of the azimuthal anisotropy (v₂) of dielectrons (e⁺e⁻ pairs) at mid-rapidity from √( sNN)=200 GeV Au + Au collisions with the STAR detector at the Relativistic Heavy Ion Collider (RHIC), presented as a function of transverse momentum (p T) for different invariant-mass regions. In the mass region Mee<1.1 GeV/c² the dielectron v₂ measurements are found to be consistent with expectations from π⁰,η,ω, and Φ decay contributions. In the mass region 1.1ee<2.9GeV/c², the measured dielectron v₂ is consistent, within experimental uncertainties, with that from the cc¯ contributions.

  15. Dielectron Azimuthal Anisotropy at mid-rapidity in Au+Au collisions at root s=200GeV

    DOE PAGES

    Adamczyk, L.

    2014-12-11

    We report on the first measurement of the azimuthal anisotropy (v₂) of dielectrons (e⁺e⁻ pairs) at mid-rapidity from √( sNN)=200 GeV Au + Au collisions with the STAR detector at the Relativistic Heavy Ion Collider (RHIC), presented as a function of transverse momentum (p T) for different invariant-mass regions. In the mass region Mee<1.1 GeV/c² the dielectron v₂ measurements are found to be consistent with expectations from π⁰,η,ω, and Φ decay contributions. In the mass region 1.1ee<2.9GeV/c², the measured dielectron v₂ is consistent, within experimental uncertainties, with that from the cc¯ contributions.

  16. Software Independent Verification and Validation (SIV&V) Simplified

    DTIC Science & Technology

    2006-12-01

    Configuration Item I/O Input/Output I2V2 Independent Integrated Verification and Validation IBM International Business Machines ICD Interface...IPT Integrated Product Team IRS Interface Requirements Specification ISD Integrated System Diagram ITD Integrated Test Description ITP ...programming languages such as COBOL (Common Business Oriented Language) (Codasyl committee 1960), and FORTRAN (FORmula TRANslator) ( IBM 1952) (Robat 11

  17. NaV channel variants in patients with painful and nonpainful peripheral neuropathy

    PubMed Central

    Wadhawan, Samir; Pant, Saumya; Golhar, Ryan; Kirov, Stefan; Thompson, John; Jacobsen, Leslie; Qureshi, Irfan; Ajroud-Driss, Senda; Freeman, Roy; Simpson, David M.; Smith, A. Gordon; Hoke, Ahmet

    2017-01-01

    Objective: To examine the incidence of nonsynonymous missense variants in SCN9A (NaV1.7), SCN10A (NaV1.8), and SCN11A (NaV1.9) in patients with painful and nonpainful peripheral neuropathy. Methods: Next-generation sequencing was performed on 457 patient DNA samples provided by the Peripheral Neuropathy Research Registry (PNRR). The patient diagnosis was as follows: 278 idiopathic peripheral neuropathy (67% painful and 33% nonpainful) and 179 diabetic distal polyneuropathy (77% painful and 23% nonpainful). Results: We identified 36 (SCN9A), 31 (SCN10A), and 15 (SCN11A) nonsynonymous missense variants, with 47.7% of patients carrying a low-frequency (minor allele frequency <5%) missense variant in at least 1 gene. The incidence of previously reported gain-of-function missense variants was low (≤3%), and these were detected in patients with and without pain. There were no significant differences in missense variant allele frequencies of any gene, or SCN9A haplotype frequencies, between PNRR patients with painful or nonpainful peripheral neuropathy. PNRR patient SCN9A and SCN11A missense variant allele frequencies were not significantly different from the Exome Variant Server, European American (EVS-EA) reference population. For SCN10A, there was a significant increase in the alternate allele frequency of the common variant p.V1073A and low-frequency variant pS509P in PNRR patients compared with EVS-EA and the 1000 Genomes European reference populations. Conclusions: These results suggest that identification of a genetically defined subpopulation for testing of NaV1.7 inhibitors in patients with peripheral neuropathy is unlikely and that additional factors, beyond expression of previously reported disease “mutations,” are more important for the development of painful neuropathy than previously discussed. PMID:29264398

  18. Regional brain [(11)C]carfentanil binding following tobacco smoking.

    PubMed

    Domino, Edward F; Hirasawa-Fujita, Mika; Ni, Lisong; Guthrie, Sally K; Zubieta, Jon Kar

    2015-06-03

    To determine if overnight tobacco abstinent carriers of the AG or GG (*G) vs. the AA variant of the human mu opioid receptor (OPRM1) A118G polymorphism (rs1799971) differ in [(11)C]carfentanil binding after tobacco smoking. Twenty healthy American male smokers who abstained from tobacco overnight were genotyped and completed positron emission tomography (PET) scans with the mu opioid receptor agonist, [(11)C]carfentanil. They smoked deniconized (denic) and average nicotine (avnic) cigarettes during the PET scans. Smoking avnic cigarette decreased the binding potential (BPND) of [(11)C]carfentanil in the right medial prefrontal cortex (mPfc; 6, 56, 18), left anterior medial prefrontal cortex (amPfc; -2, 46, 44), right ventral striatum (vStr; 16, 3, -10), left insula (Ins; -42, 10, -12), right hippocampus (Hippo; 18, -6, -14) and left cerebellum (Cbl; -10, -88, -34), and increased the BPND in left amygdala (Amy; -20, 0, -22), left putamen (Put; -22, 10, -6) and left nucleus accumbens (NAcc; -10, 12, -8). In the AA allele carriers, avnic cigarette smoking significantly changed the BPND compared to after denic smoking in most brain areas listed above. However in the *G carriers the significant BPND changes were confirmed in only amPfc and vStr. Free mu opioid receptor availability was significantly less in the *G than the AA carriers in the Amy and NAcc. The present study demonstrates that BPND changes induced by avnic smoking in OPRM1 *G carriers were blunted compared to the AA carriers. Also *G smokers had less free mu opioid receptor availability in Amy and NAcc. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Bcl11b-A Critical Neurodevelopmental Transcription Factor-Roles in Health and Disease.

    PubMed

    Lennon, Matthew J; Jones, Simon P; Lovelace, Michael D; Guillemin, Gilles J; Brew, Bruce J

    2017-01-01

    B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. It works as both a genetic suppressor and activator, acting directly, attaching to promoter regions, as well as indirectly, attaching to promoter-bound transcription factors. Bcl11b is a fundamental transcription factor in fetal development, with important roles for the differentiation and development of various neuronal subtypes in the central nervous system (CNS). It has been used as a specific marker of layer V subcerebral projection neurons as well as striatal interneurons. Bcl11b also has critical developmental functions in the immune, integumentary and cardiac systems, to the extent that Bcl11b knockout mice are incompatible with extra-uterine life. Bcl11b has been implicated in a number of disease states including Huntington's disease, Alzheimer's disease, HIV and T-Cell malignancy, amongst others. Bcl11b is a fascinating protein whose critical roles in the CNS and other parts of the body are yet to be fully explicated. This review summarizes the current literature on Bcl11b and its functions in development, health, and disease as well as future directions for research.

  20. Increased TeV gamma-ray activity from Mrk 421 on January 1-4

    NASA Astrophysics Data System (ADS)

    Wood, J.; Martinez, I.; Lauer, R.

    2017-01-01

    The HAWC Observatory measured increased gamma-ray fluxes from the direction of BL Lac Markarian 421 (z=0.031) over four successive nights starting on January 1, 2017: Transit Starting 07:40:55 UTC on Jan 1, 2017 (MJD 57754.32): Flux = (4.8 +/- 1.1) x10^-11 photons/cm2/s [2.5 Crab Units] Transit Starting 07:36:59 UTC on Jan 2, 2017 (MJD 57755.32): Flux = (3.6 +/- 1.0) x10^-11 photons/cm2/s [1.9 Crab Units] Transit Starting 07:33:04 UTC on Jan 3, 2017 (MJD 57756.31): Flux = (4.0 +/- 1.0) x10^-11 photons/cm2/s [2.1 Crab Units] Transit Starting 07:29:08 UTC on Jan 4, 2017 (MJD 57757.31): Flux = (4.1 +/- 1.0) x10^-11 photons/cm2/s [2.2 Crab Units] All fluxes reported here are the integral flux above 1 TeV averaged over the 6 hour source transit obtained from a maximum likelihood fit under the assumption of a fixed spectral shape with power law index of 2.2 and exponential cut-off at 5 TeV. This shape is the current best fit for HAWC data from Markarian 421. The highest flux occurred on Jan 1, 2017.

  1. Automatic detection of motor unit innervation zones of the external anal sphincter by multichannel surface EMG.

    PubMed

    Ullah, Khalil; Cescon, Corrado; Afsharipour, Babak; Merletti, Roberto

    2014-12-01

    A method to detect automatically the location of innervation zones (IZs) from 16-channel surface EMG (sEMG) recordings from the external anal sphincter (EAS) muscle is presented in order to guide episiotomy during child delivery. The new algorithm (2DCorr) is applied to individual motor unit action potential (MUAP) templates and is based on bidimensional cross correlation between the interpolated image of each MUAP template and two images obtained by flipping upside-down (around a horizontal axis) and left-right (around a vertical axis) the original one. The method was tested on 640 simulated MUAP templates of the sphincter muscle and compared with previously developed algorithms (Radon Transform, RT; Template Match, TM). Experimental signals were detected from the EAS of 150 subjects using an intra-anal probe with 16 equally spaced circumferential electrodes. The results of the three algorithms were compared with the actual IZ location (simulated signal) and with IZ location provided by visual analysis (VA) (experimental signals). For simulated signals, the inter quartile error range (IQR) between the estimated and the actual locations of the IZ was 0.20, 0.23, 0.42, and 2.32 interelectrode distances (IED) for the VA, 2DCorr, RT and TM methods respectively. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. The influence of electromyographic recording methods and the innervation zone on the mean power frequency-torque relationships.

    PubMed

    Herda, Trent J; Zuniga, Jorge M; Ryan, Eric D; Camic, Clayton L; Bergstrom, Haley C; Smith, Doug B; Weir, Joseph P; Cramer, Joel T; Housh, Terry J

    2015-06-01

    This study examined the effects of electromyographic (EMG) recording methods and innervation zone (IZ) on the mean power frequency (MPF)-torque relationships. Nine subjects performed isometric ramp muscle actions of the leg extensors from 5% to 100% of maximal voluntary contraction with an eight channel linear electrode array over the IZ of the vastus lateralis. The slopes were calculated from the log-transformed monopolar and bipolar EMG MPF-torque relationships for each channel and subject and 95% confidence intervals (CI) were constructed around the slopes for each relationship and the composite of the slopes. Twenty-two to 55% of the subjects exhibited 95% CIs that did not include a slope of zero for the monopolar EMG MPF-torque relationships while 25-75% of the subjects exhibited 95% CIs that did not include a slope of zero for the bipolar EMG MPF-torque relationships. The composite of the slopes from the EMG MPF-torque relationships were not significantly different from zero for any method or channel, however, the method and IZ location slightly influenced the number of significant slopes on a subject-by-subject basis. The log-transform model indicated that EMG MPF-torque patterns were nonlinear regardless of recording method or distance from the IZ. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. 1,1-Dichloroethylene (1,1-DCE)

    Integrated Risk Information System (IRIS)

    1,1 - Dichloroethylene ( 1,1 - DCE ) ; CASRN 75 - 35 - 4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments f

  4. 76 FR 35017 - United States et al. v. United Regional Health Care System; Public Comments and Response on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... DEPARTMENT OF JUSTICE Antitrust Division United States et al. v. United Regional Health Care... proposed Final Judgment in United States and State of Texas v. United Regional Health Care System, Civil... Texas, (RCO) Plaintiffs, V. United Regional Health Care System, Defendant. Case No.: 7:11-cv-00030...

  5. Final Environmental Assessment for Establishment of a New C-130 Landing Zone for 58 SOW

    DTIC Science & Technology

    2013-10-01

    Ai rport .~ Pueblo Roswell International Air Center Ro<-f Figure 1-1 . Regional Map Final Environmental...t lo ad -b ea rin g st re ng th ? M in im al c ity li gh ts ? M in im al s en si tiv e re ce pt or co ns tr ai nt s? C ra sh /fi re /re...af fic vo lu m es to m in im iz e sc he du lin g co nf lic ts ? N on -m ili ta ry /a us te re a irf ie ld ac tiv el

  6. 3. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer July 1966 SOUTH AND EAST (STREET) ELEVATIONS (NOTE: Chimney in gable hidden by tree at left, windows of fourth bay hidden by tree at right) - Thomas Starbuck Homestead, 11 Milk Street, Nantucket, Nantucket County, MA

  7. 2. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer July 1966 SOUTH AND EAST (STREET) ELEVATIONS (NOTE: Chimney in gable hidden by tree at left, windows of fourth bay hidden by tree at right) - Thomas Starbuck Homestead, 11 Milk Street, Nantucket, Nantucket County, MA

  8. Infusing and selecting V&V activities

    NASA Technical Reports Server (NTRS)

    Feather, M. S.

    2002-01-01

    The evolving nature of software development poses a continuing series of challenges for V&V. In response, the V&V community selectively adapts the use of existing V&V activities, and introduces new and improved ones.

  9. III-V/Active-Silicon Integration for Low-Cost High-Performance Concentrator Photovoltaics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ringel, Steven

    This FPACE project was motivated by the need to establish the foundational pathway to achieve concentrator solar cell efficiencies greater than 50%. At such an efficiency, DOE modeling projected that a III-V CPV module cost of $0.50/W or better could be achieved. Therefore, the goal of this project was to investigate, develop and advance a III-V/Si mulitjunction (MJ) CPV technology that can simultaneously address the primary cost barrier for III-V MJ solar cells while enabling nearly ideal MJ bandgap profiles that can yield efficiencies in excess of 50% under concentrated sunlight. The proposed methodology was based on use of ourmore » recently developed GaAsP metamorphic graded buffer as a pathway to integrate unique GaAsP and Ga-rich GaInP middle and top junctions having bandgaps that are adjustable between 1.45 – 1.65 eV and 1.9 – 2.1 eV, respectively, with an underlying, 1.1 eV active Si subcell/substrate. With this design, the Si can be an active component sub-cell due to the semi-transparent nature of the GaAsP buffer with respect to Si as well as a low-cost alternative substrate that is amenable to scaling with existing Si foundry infrastructure, providing a reduction in materials cost and a low cost path to manufacturing at scale. By backside bonding of a SiGe, a path to exceed 50% efficiency is possible. Throughout the course of this effort, an expansive range of new understanding was achieved that has stimulated worldwide efforts in III-V/Si PV R&D that spanned materials development, metamorphic device optimization, and complete III-V/Si monolithic integration. Highlights include the demonstration of the first ideal GaP/Si interfaces grown by industry-standard MOCVD processes, the first high performance metamorphic tunnel junctions designed for III-V/Si integration, record performance of specific metamorphic sub-cell designs, the first fully integrated GaInP/GaAsP/Si double (1.7 eV/1.1 eV) and triple (1.95 eV/1.5 eV/1.1 eV) junction solar cells, the

  10. The Hard X-ray 20-40 keV AGN Luminosity Function

    NASA Technical Reports Server (NTRS)

    Beckmann, V.; Soldi, S.; Shrader, C. R.; Gehrels, N.; Produit, N.

    2006-01-01

    We have compiled a complete, significance limited extragalactic sample based on approximately 25,000 deg(sup 2) to a limiting flux of 3 x 10(exp -11) ergs per square centimeter per second. (approximately 7,000 deg(sup 2)) to a flux limit of 10(exp -11) ergs per square centimeter per second)) in the 20 - 40 keV band with INTEGRAL. We have constructed a detailed exposure map to compensate for effects of non-uniform exposure. The flux-number relation is best described by a power-law with a slope of alpha = 1.66 plus or minus 0.11. The integration of the cumulative flux per unit area leads to f(sub 20-40 keV) = 2.6 x 10(exp -10) ergs per square centimeter per second per sr(sup -1) which is about 1% of the known 20-40 keV X-ray background. We present the first luminosity function of AGN in the 20-40 keV energy range, based on 68 extragalactic objects detected by the imager IBIS/ISGRI on-board INTEGRAL. The luminosity function shows a smoothly connected two power-law form, with an index of gamma (sub 1) = 0.9 below, and gamma (sub 2) = 2.2 above the turn-over luminosity of L(sub *), = 4.6 x 10(sup 43) ergs per second. The emissivity of all INTEGRAL AGNs per unit volume is W(sub 20-40keV)(greater than 10(sup 41) ergs per second) = 2.8 x 10(sup 38) ergs per second h(sup 3)(sub 70) Mpc(sup -3). These results are consistent with those derived in the 2-20keV energy band and do not show a significant contribution by Compton-thick objects. Because the sample used in this study is truly local (z(raised bar) = 0.022)), only limited conclusions can be drawn for the evolution of AGNs in this energy band. But the objects explaining the peak in the cosmic X-ray background are likely to be either low luminosity AGN (L(sub x) less than 10(sup 41) ergs per second) or of other type, such as intermediate mass black holes, clusters, and star forming regions.

  11. Bilateral comparison of 10 V standards between the NSAI-NML (Ireland) and the BIPM, January to February 2013 (part of the ongoing BIPM key comparison BIPM.EM-K11.b)

    NASA Astrophysics Data System (ADS)

    Power, O.; Chayramy, R.; Solve, S.; Stock, M.

    2014-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.b, a comparison of the 10 V voltage reference standards of the BIPM and the National Standards Authority of Ireland-National Metrology Laboratory (NSAI-NML), Dublin, Ireland, was carried out from January to February 2013. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM_8 (Z8) and BIPM_9 (Z9), were transported by freight to NSAI-NML. At NSAI-NML, the reference standard for DC voltage at the 10 V level consists of a group of characterized Zener diode-based electronic voltage standards. The output EMF (electromotive force) of each travelling standard was measured by direct comparison with the group standard. At the BIPM the travelling standards were calibrated, before and after the measurements at NSAI-NML, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the value assigned to DC voltage standard by NSAI-NML, at the level of 10 V, at NSAI-NML, UNML, and that assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 5 February 2013. UNML - UBIPM = -0.63 µV uc = 1.31 µV, at 10 V where uc is thecombined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NSAI-NML,based on KJ-90, and the uncertainty related to the comparison. The comparison results show that the voltage standards maintained by NSAI-NML and the BIPM were equivalent, within their stated standard uncertainties, on the mean date of the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according

  12. Elastin Degradation by Cathepsin V Requires Two Exosites*

    PubMed Central

    Du, Xin; Chen, Nelson L. H.; Wong, Andre; Craik, Charles S.; Brömme, Dieter

    2013-01-01

    Cathepsin V is a highly effective elastase and has been implicated in physiological and pathological extracellular matrix degradation. However, its mechanism of action remains elusive. Whereas human cathepsin V exhibits a potent elastolytic activity, the structurally homologous cathepsin L, which shares a 78% amino acid sequence, has only a minimal proteolytic activity toward insoluble elastin. This suggests that there are distinct structural domains that play an important role in elastinolysis. In this study, a total of 11 chimeras of cathepsins V and L were generated to identify elastin-binding domains in cathepsin V. Evaluation of these chimeras revealed two exosites contributing to the elastolytic activity of cathepsin V that are distant from the active cleft of the protease and are located in surface loop regions. Replacement of exosite 1 or 2 with analogous residues from cathepsin L led to a 75 and 43% loss in the elastolytic activity, respectively. Replacement of both exosites yielded a non-elastase variant similar to that of cathepsin L. Identification of these exosites may contribute to the design of inhibitors that will only affect the elastolytic activity of cysteine cathepsins without interfering with other physiological protease functions. PMID:24121514

  13. [Determination of 11 mycotoxins in baked foods and raw materials by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high-resolution mass spectrometry].

    PubMed

    Li, Rong; He, Chunmei; Yang, Luqi; Wang, Yong; Zhang, Pengjie; Gao, Yongqing

    2017-08-08

    A method for the determination of 11 mycotoxins in baked foods and raw materials by ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high-resolution mass spectrometry (UPLC-HRMS) is reported in this paper. The samples were extracted with 20 mL 90% (v/v) acetonitrile aqueous solution containing 1% (v/v) formic acid, and the extracts were salted out by 2.0 g MgSO 4 and 0.5 g NaCl, cleaned up by 300 mg C18. The analytes were carried out on a CORTECS C18 column (100 mm×2.1 mm, 1.6 μ m) by gradient elution with 2 mmol/L ammonium acetate with 0.1% (v/v) formic acid aqueous solution and 2 mmol/L ammonium acetate methanol with 0.1% (v/v) formic acid. The results showed that the 11 mycotoxins had good linear relationships in their respective mass concentration ranges. The correlation coefficients were not less than 0.9960 and the limits of quantitation (LOQs) were from 0.15 to 20.00 μ g/kg. The recoveries of the 11 mycotoxins in bread ranged from 64.38% to 122.61% with the relative standard deviations (RSDs) from 1.52% to 12.99% at three spiked levels ( n =6). The method is demonstrated to be simple, fast, highly sensitive, reliable and it is effective to detect common mycotoxins in baked foods and raw materials.

  14. The Strongest 40 keV Electron Acceleration By ICME-driven Shocks At 1 AU

    NASA Astrophysics Data System (ADS)

    Yang, L.; Wang, L.; Li, G.; Wimmer-Schweingruber, R. F.; He, J.; Tu, C. Y.; Bale, S. D.

    2017-12-01

    Here we present a comprehensive case study of the in situ electron acceleration at the two ICME-driven shocks observed by WIND/3DP on February 11, 2000 and July 22, 2004. For the 11 February 2000 shock (the 22 July 2004 shock), the shocked electrons in the downstream show significant flux enhancements over the ambient solar wind electrons at energies up to 40 keV (66 keV) with a 6.0 times (1.9 times) ehancment at 40 keV, the strongest among all the quasi-perpendicular (quasi-parallel) ICME-driven shocks observed by the WIND spacecraft at 1 AU from 1995 through 2014. We find that in both shocks, the shocked electron fluxes at 0.5-40 keV fit well to a double power-law spectrum, J ˜ E-β, bending up at ˜2 keV. In the downstream, these shocked electrons show stronger fluxes in the anti-sunward direction, but their enhancement over the ambient fluxes peaks near 90° pitch angle (PA). For the 11 February 2000 shock, the electron spectral index, β, appears to not vary with the electron PA, while for the 22 July 2004 shock, β roughly decreases from the anti-sunward PA direction to the sunward PA direction. All of these spectral indexes are strongly larger than the theoretical prediction of diffusive shock acceleration. At energies above (below) 2 keV, however, the shocked electron β is similar to the solar wind superhalo (halo) electrons observed at quiet times. These results suggest that the electron acceleration at the ICME-driven shocks at 1 AU may favor the shock drift acceleration, and the superthermal electrons accelerated by the interplanetary shocks may contribute to the formation of the halo and superhalo electron populations in the solar wind.

  15. Apollo 11 Lunar Message For Mankind- Reproduction

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Millions of people on Earth watched via television as a message for all mankind was delivered to the Mare Tranquilitatis (Sea of Tranquility) region of the Moon during the historic Apollo 11 mission, where it still remains today. This photograph is a reproduction of the commemorative plaque that was attached to the leg of the Lunar Module (LM), Eagle, engraved with the following words: 'Here men from the planet Earth first set foot upon the Moon July, 1969 A.D. We came in peace for all of mankind.' It bears the signatures of the Apollo 11 astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin, Jr., Lunar Module (LM) pilot along with the signature of the U.S. President Richard M. Nixon. The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  16. Isolation and characterization of a novel electricity-producing yeast, Candida sp. IR11.

    PubMed

    Lee, Yun-Yeong; Kim, Tae Gwan; Cho, Kyung-Suk

    2015-09-01

    A novel iron-reducing yeast, Candida sp. IR11, was isolated from an anodic biofilm in a MFC reactor fed glucose as a feedstock. 200-250 mV of voltage was produced in the air-cathode MFC inoculated with a pure culture of the strain IR11 where glucose was supplied as a feedstock. When the strain IR11 was inoculated into a conventional MFC treating rejected wastewater from an upflow anaerobic sludge blanket, maximum power density and coulombic efficiency were enhanced from 15.2 ± 0.36 to 20.6 ± 1.52 mW m(-2) and from 14.4 ± 0.45% to 21.9 ± 0.71%, respectively. In addition, the inoculation with IR11 improved COD removal from 79.1 ± 1.53% to 91.3 ± 5.29%. The quantitative PCR results showed that the strain IR11 successfully attached the anodic biofilm of the MFC reactors. These results indicate that Candida sp. IR11 is a promising biocatalyst for the enhancement of MFC performance. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.

    PubMed

    Yang, Kai-Chun; Stepanov, Vladimir; Amini, Nahid; Martinsson, Stefan; Takano, Akihiro; Nielsen, Jacob; Bundgaard, Christoffer; Bang-Andersen, Benny; Grimwood, Sarah; Halldin, Christer; Farde, Lars; Finnema, Sjoerd J

    2017-02-01

    [ 11 C]Lu AE92686 is a positron emission tomography (PET) radioligand that has recently been validated for examining phosphodiesterase 10A (PDE10A) in the human striatum. [ 11 C]Lu AE92686 has high affinity for PDE10A (IC 50  = 0.39 nM) and may also be suitable for examination of the substantia nigra, a region with low density of PDE10A. Here, we report characterization of regional [ 11 C]Lu AE92686 binding to PDE10A in the nonhuman primate (NHP) brain. A total of 11 PET measurements, seven baseline and four following pretreatment with unlabeled Lu AE92686 or the structurally unrelated PDE10A inhibitor MP-10, were performed in five NHPs using a high resolution research tomograph (HRRT). [ 11 C]Lu AE92686 binding was quantified using a radiometabolite-corrected arterial input function and compartmental and graphical modeling approaches. Regional time-activity curves were best described with the two-tissue compartment model (2TCM). However, the distribution volume (V T ) values for all regions were obtained by the Logan plot analysis, as reliable cerebellar V T values could not be derived by the 2TCM. For cerebellum, a proposed reference region, V T values increased by ∼30 % with increasing PET measurement duration from 63 to 123 min, while V T values in target regions remained stable. Both pretreatment drugs significantly decreased [ 11 C]Lu AE92686 binding in target regions, while no significant effect on cerebellum was observed. Binding potential (BP ND ) values, derived with the simplified reference tissue model (SRTM), were 13-17 in putamen and 3-5 in substantia nigra and correlated well to values from the Logan plot analysis. The method proposed for quantification of [ 11 C]Lu AE92686 binding in applied studies in NHP is based on 63 min PET data and SRTM with cerebellum as a reference region. The study supports that [ 11 C]Lu AE92686 can be used for PET examinations of PDE10A binding also in substantia nigra.

  18. Analysis of Carbon Fiber’s X-Ray Microscopic Structure

    DTIC Science & Technology

    1989-08-16

    this translation were extracted from the best quality copy available. Aecesslem For icr: S SRA&I1 STIC TAB Una-oun ced Just Ifleatlo By D st ri lutI am...22, No. 5, 1968 FagES Tra1;slatez: 20-2"- r - r r,. s f-~ 1~ 2022’-D(( S -EE~3 Lec Kanner Associates V~.Bcx 517 s:c: d Citv C.A 9 4 0’ ANALYSIS OF...diffraction for fac_ (002) is es eciallv intense, with th, inter-face distance equal to 1/2 Je th carbmn fiber’s lattice constan. Becau2 iz - s

  19. SEMICONDUCTOR INTEGRATED CIRCUITS 8.64-11.62 GHz CMOS VCO and divider in a zero-IF 802.11a/b/g WLAN and Bluetooth application

    NASA Astrophysics Data System (ADS)

    Yu, Sun; Niansong, Mei; Bo, Lu; Yumei, Huang; Zhiliang, Hong

    2010-10-01

    A fully integrated VCO and divider implemented in SMIC 0.13-μm RFCMOS 1P8M technology with a 1.2 V supply voltage is presented. The frequency of the VCO is tuning from 8.64 to 11.62 GHz while the quadrature LO signals for 802.11a WLAN in 5.8 GHz band or for 802.11b/g WLAN and Bluetooth in 2.4 GHz band can be obtained by a frequency division by 2 or 4, respectively. A 6 bit switched capacitor array is applied for precise tuning of all necessary frequency bands. The testing results show that the VCO has a phase noise of—113 dBc @ 1 MHz offset from the carrier of 5.5 GHz by dividing VCO output by two and the VCO core consumes 3.72 mW. The figure-of-merit for the tuning-range (FOMT) of the VCO is -192.6 dBc/Hz.

  20. IgE and allergen-specific immunotherapy-induced IgG4 recognize similar epitopes of Bet v 1, the major allergen of birch pollen.

    PubMed

    Groh, N; von Loetzen, C S; Subbarayal, B; Möbs, C; Vogel, L; Hoffmann, A; Fötisch, K; Koutsouridou, A; Randow, S; Völker, E; Seutter von Loetzen, A; Rösch, P; Vieths, S; Pfützner, W; Bohle, B; Schiller, D

    2017-05-01

    Allergen-specific immunotherapy (AIT) with birch pollen generates Bet v 1-specific immunoglobulin (Ig)G 4 which blocks IgE-mediated hypersensitivity mechanisms. Whether IgG 4 specific for Bet v 1a competes with IgE for identical epitopes or whether novel epitope specificities of IgG 4 antibodies are developed is under debate. We sought to analyze the epitope specificities of IgE and IgG 4 antibodies from sera of patients who received AIT. 15 sera of patients (13/15 received AIT) with Bet v 1a-specific IgE and IgG 4 were analyzed. The structural arrangements of recombinant (r)Bet v 1a and rBet v 1a _11x , modified in five potential epitopes, were analyzed by circular dichroism and nuclear magnetic resonance spectroscopy. IgE binding to Bet v 1 was assessed by ELISA and mediator release assays. Competitive binding of monoclonal antibodies specific for Bet v 1a and serum IgE/IgG 4 to rBet v 1a and serum antibody binding to a non-allergenic Bet v 1-type model protein presenting an individual epitope for IgE was analyzed in ELISA and western blot. rBet v 1a _11x had a Bet v 1a - similar secondary and tertiary structure. Monomeric dispersion of rBet v 1a _11x was concentration and buffer-dependent. Up to 1500-fold increase in the EC 50 for IgE-mediated mediator release induced by rBet v 1a _11x was determined. The reduction of IgE and IgG 4 binding to rBet v 1a _11x was comparable in 67% (10/15) of sera. Bet v 1a-specific monoclonal antibodies inhibited binding of serum IgE and IgG 4 to 66.1% and 64.9%, respectively. Serum IgE and IgG 4 bound specifically to an individual epitope presented by our model protein in 33% (5/15) of sera. Patients receiving AIT develop Bet v 1a-specific IgG 4 which competes with IgE for partly identical or largely overlapping epitopes. The similarities of epitopes for IgE and IgG 4 might stimulate the development of epitope-specific diagnostics and therapeutics. © 2016 John Wiley & Sons Ltd.

  1. Building a database for brain 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects.

    PubMed

    Paul, Soumen; Gallagher, Evan; Liow, Jeih-San; Mabins, Sanche; Henry, Katharine; Zoghbi, Sami S; Gunn, Roger N; Kreisl, William C; Richards, Erica M; Zanotti-Fregonara, Paolo; Morse, Cheryl L; Hong, Jinsoo; Kowalski, Aneta; Pike, Victor W; Innis, Robert B; Fujita, Masahiro

    2018-01-01

    Translocator protein 18 kDa (TSPO) has been widely imaged as a marker of neuroinflammation using several radioligands, including [ 11 C]PBR28. In order to study the effects of age, sex, and obesity on TSPO binding and to determine whether this binding can be accurately assessed using fewer radio high-performance liquid chromatography (radio-HPLC) measurements of arterial blood samples, we created a database of 48 healthy subjects who had undergone [ 11 C]PBR28 scans (23 high-affinity binders (HABs) and 25 mixed-affinity binders (MABs), 20 F/28 M, age: 40.6 ± 16.8 years). After analysis by Logan plot using 23 metabolite-corrected arterial samples, total distribution volume ( V T ) was found to be 1.2-fold higher in HABs across all brain regions. Additionally, the polymorphism plot estimated nondisplaceable uptake ( V ND ) as 1.40 mL · cm -3 , which generated a specific-to-nondisplaceable ratio ( BP ND ) of 1.6 ± 0.6 in HABs and 1.1 ± 0.6 in MABs. V T increased significantly with age in nearly all regions and was well estimated with radio-HPLC measurements from six arterial samples. However, V T did not correlate with body mass index and was not affected by sex. These results underscore which patient characteristics should be accounted for during [ 11 C]PBR28 studies and suggest ways to perform such studies more easily and with fewer blood samples.

  2. Tempering of Mn and Mn-Si-V dual-phase steels

    NASA Astrophysics Data System (ADS)

    Speich, G. R.; Schwoeble, A. J.; Huffman, G. P.

    1983-06-01

    Changes in the yield behavior, strength, and ductility of a Mn and a Mn-Si-V d11Al-phase (ferrite-martensite) steel were investigated after tempering one hour at 200 to 600 °C. The change in yield behavior was complex in both steels with the yield strength first increasing and then decreasing as the tempering temperature was increased. This complex behavior is attributed to a combination of factors including carbon segregation to dislocations, a return of discontinuous yielding, and the relief of resid11Al stresses. In contrast, the tensile strength decreased continuously as the tempering temperature was increased in a manner that could be predicted from the change in hardness of the martensite phase using a simple composite strengthening model. The initial tensile ductility (total elongation) of the Mn-Si-V steel was much greater than that of the Mn steel. However, upon tempering up to 400 °C, the ductility of the Mn-Si-V decreased whereas that of the Mn steel increased. As a result, both steels had similar ductilities after tempering at 400 °C or higher temperatures. These results are attributed to the larger amounts of retained austenite in the Mn-Si-V steel (9 pct) compared to the Mn steel (3 pct) and its contribution to tensile ductility by transforming to martensite during plastic straining. Upon tempering at 400 °C, the retained austenite decomposes to bainite and its contribution to tensile ductility is eliminated.

  3. Geologic Mapping of V-19, V-28, and V-53

    NASA Technical Reports Server (NTRS)

    Stofan, E. R.; Martin, P.; Guest, J. E.

    2008-01-01

    The Sedna Planitia Quadrangle (V-19) extend from 25 deg N - 50 deg N latitude, 330 deg - 0 deg longitude. The quadrangle contains the northern-most portion of western Eistla Regio and the Sedna Planitia lowlands. Geologic maps of Sedna Planitia (V-199), Hecate Chasma (V-28) quadrangles have been completed at the 1:5,000,000 scale as part of the NASA Planetary Geologic Mapping Program. All quadrangles (V-53, V-28 and V-19) have been reviewed at lease once and will be resubmitted. In V-28 and V-53, more plains materials units have been mapped than in previously mapped quadrangles V-46 and V-39. V-19 is more comparable to these latter maps in terms of numbers of plains units. In V-28, all of the plains materials units to the south of the rift have an unusually high concentration of volcanic edifices, which both predate and postdate the units. A similar situation is seen in V-53 and V-19, where small edifice formation is not confined to any specific time period. In the two chasma-related quadrangles, coronae are located along the rift, as well as to the north and the south of the rifts. Coronae in both quadrangles exhibit all forms of corona topographic shapes, including depressions, rimmed depressions, plateaus and domes. In V-28 and V-53, some coronae along the rift do not have much associated volcanism; coronae with the most volcanism in these quadrangles are located at least 500 km off the rifts or on the Themis Regio highland. All three quadrangles have very horizontal stratigraphic columns, as limited contact between units prevents clear age determinations. While this results in the appearance that all units formed at the same time, the use of hachured columns for each unit illustrates the limited nature of our stratigraphic knowledge in these quadrangles, allowing for numerous possible geologic histories. The scale of resurfacing in these quadrangles is on the scale of 100s of kilometers, consistent with the fact that they lie in the most volcanic region of

  4. Superconductivity in the Narrow Gap Semiconductor RbBi 11/3Te 6

    DOE PAGES

    Malliakas, Christos D.; Chung, Duck Young; Claus, Helmut; ...

    2016-10-16

    Superconductivity was discovered in the layered compound RbBi 11/3Te 6, featuring Bi vacancies and a narrow band gap of 0.25(2) eV at room temperature. In addition, a sharp superconducting transition at similar to 3.2 K was observed in polycrystalline ingots. The superconducting volume fraction of oriented single crystals is almost 100%, confirming bulk superconductivity. Systematic Se and Sb substitutions in RbBi 11/3-ySb ySe xTe 6-x, revealed a dependence of the superconducting transition on composition that can increase the T c up to similar to 10%. The RbBi 11/3Te 6 system is the first member of the new homologous series Rb[Bimore » 2n+11/3Te 3n+6] with infinite Bi 2Te 3-like layers. Lastly, the large degree of chemical tunability of the electronic structure of the homology via doping and/or substitution gives rise to a new family of superconductors.« less

  5. A possible line feature at 73 keV from the Crab Nebula

    NASA Technical Reports Server (NTRS)

    Ling, J. C.; Mahoney, W. A.; Willett, J. B.; Jacobson, A. S.

    1979-01-01

    Evidence is reported for a possible line feature at 73 keV from the Crab Nebula. The experiment was conducted with a balloon-borne high-resolution gamma-ray spectrometer on June 10, 1974, over Palestine, Texas. The intensity and the width of the line derived from the fitting of these data are approximately 0.0038 photon per (sq cm-sec) and less than 4.9 keV FWHM, respectively. The line is superposed on a power-law continuum of 11.2 E to the -2.16 photons per (sq cm-keV) in the energy range from 53 to 300 keV, which is consistent with other measurements of the Crab Nebula spectrum.

  6. Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis.

    PubMed

    Chang, Ling-Chu; Chiang, Shih-Kai; Chen, Shuen-Ei; Yu, Yung-Luen; Chou, Ruey-Hwang; Chang, Wei-Chao

    2018-03-01

    Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. BAY 11-7085 (BAY), which is a well-known IκBα inhibitor, suppressed viability in cancer cells via induction of ferroptotic death in an NF-κB-independent manner. Reactive oxygen species scavenging, relief of lipid peroxidation, replenishment of glutathione and thiol-containing agents, as well as iron chelation, rescued BAY-induced cell death. BAY upregulated a variety of Nrf2 target genes related to redox regulation, particularly heme oxygenase-1 (HO-1). Studies with specific inhibitors and shRNA interventions suggested that the hierarchy of induction is Nrf2-SLC7A11-HO-1. SLC7A11 inhibition by erastin, sulfasalazine, or shRNA interference sensitizes BAY-induced cell death. Overexperession of SLC7A11 attenuated BAY-inhibited cell viability. The ferroptotic process induced by hHO-1 overexpression further indicated that HO-1 is a key mediator of BAY-induced ferroptosis that operates through cellular redox regulation and iron accumulation. BAY causes compartmentalization of HO-1 into the nucleus and mitochondrion, and followed mitochondrial dysfunctions, leading to lysosome targeting for mitophagy. In this study, we first discovered that BAY induced ferroptosis via Nrf2-SLC7A11-HO-1 pathway and HO-1 is a key mediator by responding to the cellular redox status. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Production and characterization of genetically modified human IL-11 variants.

    PubMed

    Sano, Emiko; Takei, Toshiaki; Ueda, Takuya; Tsumoto, Kouhei

    2017-02-01

    Interleukin-11 (IL-11) has been expected as a drug on severe thrombocytopenia caused by myelo-suppressive chemotherapy. Whereas, development of IL-11 inhibitor is also expected for a treatment against IL-11 related cancer progression. Here, we will demonstrate the creation of various kinds of genetically modified hIL-11s. Modified vectors were constructed by introducing N- or O-glycosylation site on the region of hIL-11 that does not belong to the core α-helical motif based on the predicted secondary structure. N-terminal (N: between 22 to 23 aa), the first loop (M1:70 to 71 aa), the second loop (M2:114-115 aa), the third loop (M3:160-161 aa) and C-terminal (C: 200- aa) were selected for modification. A large scale production system was established and the characteristics of modified hIL-11s were evaluated. The structure was analyzed by amino acid sequence and composition analysis and CD-spectra. Glycan was assessed by monosaccharide composition analysis. Growth promoting activity and biological stability were analyzed by proliferation of T1165 cells. N-terminal modified proteins were well glycosylated and produced. Growth activity of 3NN with NASNASNAS sequence on N-terminal was about tenfold higher than wild type (WT). Structural and biological stabilities of 3NN were also better than WT and residence time in mouse blood was longer than WT. M1 variants lacked growth activity though they are well glycosylated and secondary structure is very stable. Both of 3NN and OM1 with AAATPAPG on M1 associated with hIL-11R strongly. These results indicate N-terminal and M1 variants will be expected for practical use as potent agonists or antagonists of hIL-11. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Multiwavelength observations of the TeV binary LS I +61° 303 with Veritas, Fermi-LAT, and Swift/xrt during a TeV outburst

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aliu, E.; Archambault, S.; Behera, B.

    2013-12-10

    We present the results of a multiwavelength observational campaign on the TeV binary system LS I +61° 303 with the VERITAS telescope array (>200 GeV), Fermi-LAT (0.3-300 GeV), and Swift/XRT (2-10 keV). The data were taken from 2011 December through 2012 January and show a strong detection in all three wavebands. During this period VERITAS obtained 24.9 hr of quality selected livetime data in which LS I +61° 303 was detected at a statistical significance of 11.9σ. These TeV observations show evidence for nightly variability in the TeV regime at a post-trial significance of 3.6σ. The combination of the simultaneouslymore » obtained TeV and X-ray fluxes do not demonstrate any evidence for a correlation between emission in the two bands. For the first time since the launch of the Fermi satellite in 2008, this TeV detection allows the construction of a detailed MeV-TeV spectral energy distribution from LS I +61° 303. This spectrum shows a distinct cutoff in emission near 4 GeV, with emission seen by the VERITAS observations following a simple power-law above 200 GeV. This feature in the spectrum of LS I +61° 303, obtained from overlapping observations with Fermi-LAT and VERITAS, may indicate that there are two distinct populations of accelerated particles producing the GeV and TeV emission.« less

  9. Ground and excited state dissociation dynamics of ionized 1,1-difluoroethene.

    PubMed

    Gridelet, E; Dehareng, D; Locht, R; Lorquet, A J; Lorquet, J C; Leyh, B

    2005-09-22

    The kinetic energy release distributions (KERDs) for the fluorine atom loss from the 1,1-difluoroethene cation have been recorded with two spectrometers in two different energy ranges. A first experiment uses dissociative photoionization with the He(I) and Ne(I) resonance lines, providing the ions with a broad internal energy range, up to 7 eV above the dissociation threshold. The second experiment samples the metastable range, and the average ion internal energy is limited to about 0.2 eV above the threshold. In both energy domains, KERDs are found to be bimodal. Each component has been analyzed by the maximum entropy method. The narrow, low kinetic energy components display for both experiments the characteristics of a statistical, simple bond cleavage reaction: constraint equal to the square root of the fragment kinetic energy and ergodicity index higher than 90%. Furthermore, this component is satisfactorily accounted for in the metastable time scale by the orbiting transition state theory. Potential energy surfaces corresponding to the five lowest electronic states of the dissociating 1,1-C2H2F2+ ion have been investigated by ab initio calculations at various levels. The equilibrium geometry of these states, their dissociation energies, and their vibrational wavenumbers have been calculated, and a few conical intersections between these surfaces have been identified. It comes out that the ionic ground state X2B1 is adiabatically correlated with the lowest dissociation asymptote. Its potential energy curve increases in a monotonic way along the reaction coordinate, giving rise to the narrow KERD component. Two states embedded in the third photoelectron band (B2A1 at 15.95 eV and C2B2 at 16.17 eV) also correlate with the lowest asymptote at 14.24 eV. We suggest that their repulsive behavior along the reaction coordinate be responsible for the KERD high kinetic energy contribution.

  10. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.

    PubMed

    Ng, Oi-Wing; Chia, Adeline; Tan, Anthony T; Jadi, Ramesh S; Leong, Hoe Nam; Bertoletti, Antonio; Tan, Yee-Joo

    2016-04-12

    Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8(+) T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8(+) T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Internal morphology, habit and U-Th-Pb microanalysis of amphibolite-to-granulite facies zircons: geochronology of the Ivrea Zone (Southern Alps)

    NASA Astrophysics Data System (ADS)

    Vavra, Gerhard; Schmid, Rolf; Gebauer, Dieter

    Several types of growth morphologies and alteration mechanisms of zircon crystals in the high-grade metamorphic Ivrea Zone (IZ) are distinguished and attributed to magmatic, metamorphic and fluid-related events. Anatexis of pelitic metasediments in the IZ produced prograde zircon overgrowths on detrital cores in the restites and new crystallization of magmatic zircons in the associated leucosomes. The primary morphology and Th-U chemistry of the zircon overgrowth in the restites show a systematic variation apparently corresponding to the metamorphic grade: prismatic (prism-blocked) low-Th/U types in the upper amphibolite facies, stubby (fir-tree zoned) medium-Th/U types in the transitional facies and isometric (roundly zoned) high-Th/U types in the granulite facies. The primary crystallization ages of prograde zircons in the restites and magmatic zircons in the leucosomes cannot be resolved from each other, indicating that anatexis in large parts of the IZ was a single and short lived event at 299+/-5Ma (95% c. l.). Identical U/Pb ages of magmatic zircons from a metagabbro (293+/-6Ma) and a metaperidotite (300+/-6Ma) from the Mafic Formation confirm the genetic context of magmatic underplating and granulite facies anatexis in the IZ. The U-Pb age of 299+/-5Ma from prograde zircon overgrowths in the metasediments also shows that high-grade metamorphic (anatectic) conditions in the IZ did not start earlier than 20Ma after the Variscan amphibolite facies metamorphism in the adjacent Strona-Ceneri Zone (SCZ). This makes it clear that the SCZ cannot represent the middle to upper crustal continuation of the IZ. Most parts of zircon crystals that have grown during the granulite facies metamorphism became affected by alteration and Pb-loss. Two types of alteration and Pb-loss mechanisms can be distinguished by cathodoluminescence imaging: zoning-controlled alteration (ZCA) and surface-controlled alteration (SCA). The ZCA is attributed to thermal and/or decompression pulses

  12. New developments of 11C post-accelerated beams for hadron therapy and imaging

    NASA Astrophysics Data System (ADS)

    Augusto, R. S.; Mendonca, T. M.; Wenander, F.; Penescu, L.; Orecchia, R.; Parodi, K.; Ferrari, A.; Stora, T.

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10-20 MeV protons via 14N(p,α)11C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions 19F(p,X)11C and 23Na(p,X)11C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on 11C+ production [4] and proven post-acceleration of pure 10C3/6+ beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10711C6+ per spill. This intensity is appropriate using 11C ions alone for both imaging and treatment. Here we report on the ongoing feasibility studies of such approach, using the Monte Carlo particle transport code FLUKA [6,7] to simulate

  13. Electroexcitation of the P{sub 33}(1232), P{sub 11}(1440), D{sub 13}(1520), and S{sub 11}(1535) at Q{sup 2}=0.4 and 0.65 (GeV/c){sup 2}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aznauryan, I.G.; Burkert, V.D.; Egiyan, H.

    2005-01-01

    Using two approaches - dispersion relations and the isobar model - we have analyzed recent high precision CLAS data on cross sections of {pi}{sup 0}, {pi}{sup +}, and {eta} electroproduction on protons, and the longitudinally polarized electron beam asymmetry for p(e{sup {yields}},e{sup '}p){pi}{sup 0} and p(e{sup {yields}},e{sup '}n){pi}{sup +}. The contributions of the resonances P{sub 33}(1232), P{sub 11}(1440), D{sub 13}(1520), and S{sub 11}(1535) to {pi} electroproduction and of S{sub 11}(1535) to {eta} electroproduction are found. The results obtained using the two approaches are in good agreement. There is also good agreement between amplitudes of the {gamma}*N{yields}S{sub 11}(1535) transition found inmore » {pi} and {eta} electroproduction. For the first time accurate results are obtained for the longitudinal amplitudes of the P{sub 11}(1440), D{sub 13}(1520), and S{sub 11}(1535) electroexcitations on protons. A strong longitudinal response is found for the Roper resonance, which rules out presentation of this resonance as a hybrid state.« less

  14. A Versatile Glass Processor for High-Performance Photonic Platforms

    DTIC Science & Technology

    2015-12-08

    St . Louis, MO 63130 -4862 ABSTRACT Number of Papers published in peer...Skinner Professor, Electrical and Systems Engineering Department, Washington University, St . Louis, MO 63130 1. Introduction With...al iz ed re so na nc e w av el en gt h sh ift (W G M re so na nc e) a nd no rm al iz ed e la st ic m od ul us c ha ng e (rh eo lo gy ) 0

  15. [Efficacy of the treatment and secondary antifungal prophylaxis in AIDS-related histoplasmosis. Experience at the Francisco J. Muñiz Infectious Diseases Hospital in Buenos Aires].

    PubMed

    Negroni, Ricardo; Messina, Fernando; Arechavala, Alicia; Santiso, Gabriela; Bianchi, Mario

    Classic histoplasmosis is a systemic endemic mycosis due to Histoplasma capsulatum var. capsulatum. A significant reduction in the morbidity and mortality of AIDS-related histoplasmosis has been observed since the introduction of highly active antiretroviral therapy (HAART) and secondary antifungal prophylaxis. The aim of this study was to determine the current state of prognosis and treatment response of HIV-positive patients with histoplasmosis in the Francisco J. Muñiz Infectious Diseases Hospital in Buenos Aires City. A retrospective study was conducted using the demographic, clinical, immunological and treatment data of 80 patients suffering from AIDS-related histoplasmosis. Of the 80 cases studied 65 were male, the median age was 36 years, with 73.7% of the patients being drug addicts, 82.5% of the patients was not receiving HAART at diagnosis, and 58.7% of the cases had less than 50 CD4+ cells/μl at the beginning of the treatment. The initial phase of treatment consisted of intravenous amphotericin B and/or oral itraconazole for 3 months, with 78.7% of the cases showing a good clinical response. Only 26/63 patients who were discharged from hospital continued with the follow-up of the HAART, secondary prophylaxis with itraconazole or amphotericin B. Secondary prophylaxis was stopped after more than one year of HAART if the patients were asymptomatic, had two CD 4 + cell counts greater than 150cells/μl, and undetectable viral loads. No relapses were observed during a two-year follow up after prophylaxis was stopped. The treatment of histoplasmosis in HIV-positive patients was effective in 78.8% of the cases. The combination of HAART and secondary antifungal prophylaxis is safe, well tolerated, and effective. The low adherence of patients to HAART and the lack of laboratory kits for rapid histoplasmosis diagnosis should be addressed in the future. The usefulness of primary antifungal prophylaxis for cryptococcosis and histoplasmosis HIV-positive patients

  16. In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods.

    PubMed

    Alvarado-Ramírez, Eidi; Torres-Rodríguez, Josep M

    2007-07-01

    The in vitro susceptibility of Sporothrix schenckii to antifungal drugs has been determined with three different methods. Nineteen Peruvian clinical isolates of S. schenckii were tested against amphotericin B (AB), flucytosine (FC), fluconazole (FZ), itraconazole (IZ), voriconazole (VZ), and ketoconazole (KZ). Modified NCCLS M38-A, Sensititre YeastOne (SYO), and ATB Fungus 2 (ATBF2) methods were used to determine the MICs. ATCC isolates of Candida parapsilosis, Candida krusei, and Aspergillus flavus were used for quality control. Sporothrix inocula were prepared with the mycelial form growing on potato dextrose agar at 28 +/- 2 degrees C. MICs of AB, FC, FZ, and IZ were determined with all three methods, VZ with M38-A and SYO, and KZ with only SYO. The three methods showed high MICs of FZ and FC (MIC(90) of 0.5 microg/ml), being homogeneously lower than those of IZ and KZ. The M38-A method showed a variable MIC range of VZ (4.0 to 16 microg/ml); the geometric mean (GM) was 9.3 mug/ml. The MIC range of AB was wide (0.06 to 16 microg/ml), but the GM was 1.2 microg/ml, suggesting that the MIC is strain dependent. Agreement (two log(2) dilutions) between commercial techniques and the modified M38-A method was very high with FZ, IZ, and FC. In AB and VZ, the agreement was lower, being related to the antifungal concentrations of each method. The highest activity against S. schenckii was found with IZ and KZ. Lack of activity was observed with FZ, VZ, and FC. When AB is indicated for sporotrichosis, the susceptibility of the strain must be analyzed. Commercial quantitative antifungal methods have a limited usefulness in S. schenckii.

  17. Mutation Spectrum and Phenotypic Features in Noonan Syndrome with PTPN11 Mutations: Definition of Two Novel Mutations.

    PubMed

    Atik, Tahir; Aykut, Ayca; Hazan, Filiz; Onay, Huseyin; Goksen, Damla; Darcan, Sukran; Tukun, Ajlan; Ozkinay, Ferda

    2016-06-01

    To evaluate the spectrum of PTPN11 gene mutations in Noonan syndrome patients and to study the genotype-phenotype associations. In this study, twenty Noonan syndrome patients with PTPN11 mutations were included. The patients underwent a detailed clinical and physical evaluation. To identify inherited cases, parents of all mutation positive patients were analyzed. Thirteen different PTPN11 mutations, two of them being novel, were detected in the study group. These mutations included eleven missense mutations: p.G60A, p.D61N, p.Y62D, p.Y63C, p.E69Q, p.Q79R, p.Y279C,p.N308D, p.N308S, p.M504V, p.Q510R and two novel missense mutations: p.I56V and p.I282M. The frequency of cardiac abnormalities and short stature were found to be 80 % and 80 %, respectively. Mental retardation was not observed in patients having exon 8 mutations. No significant correlations were detected between other phenotypic features and genotypes. By identifying genotype-phenotype correlations, this study provides information on phenotypes observed in NS patients with different PTPN11 mutations.

  18. Characterization of Makrofol ® DE 1-1 for alpha particle radiography

    NASA Astrophysics Data System (ADS)

    El Ghazaly, M.; Aydarous, Abdulkadir; Al-Thomali, Talal A.

    2017-09-01

    Makrofol ® DE 1-1 (bisphenol-A polycarbonate) was investigated for alpha particle radiography. The edge spread function (ESF) was measured by razor-blade's edge. Makrofol ® DE 1-1 detectors were irradiated with perpendicular incident alpha particles of energy 2.5, 4 and 5.4 MeV, thereafter they were etched in 75% 6N KOH+25% C2H5OH at a temperature of 50 °C for different durations. The etched Makrofol®DE 1-1 detectors were imaged with an optical microscope equipped with a CCD camera. The results revealed that the green channel of the original RGB image provides the highest contrast comparing with red and blue channel by a factor of 27.6% of the original RGB image. The image contrast of alpha particle-irradiated Makrofol®DE 1-1 detector was found to be inversely related to the etching time since the alpha particle tracks proceed from a conical phase to spherical phase. The spatial resolution of alpha particle-irradiated Makrofol®DE 1-1 detector, in terms of line spread function, was found to deteriorate as the etching time increases for all examined alpha particle energies. The results revealed the potential capability of Makrofol®DE 1-1 detector as an efficient detector for alpha particle radiography such as autoradiography.

  19. Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain.

    PubMed

    Smith, Donald F; Dyve, Suzan; Minuzzi, Luciano; Jakobsen, Steen; Munk, Ole L; Marthi, Katalin; Cumming, Paul

    2006-06-15

    We have developed [(11)C]mirtazapine as a ligand for PET studies of antidepressant binding in living brain. However, previous studies have determined neither optimal methods for quantification of [(11)C]mirtazapine binding nor the pharmacological identity of this binding. To obtain that information, we have now mapped the distribution volume (V(d)) of [(11)C]mirtazapine relative to the arterial input in the brain of three pigs, in a baseline condition and after pretreatment with excess cold mirtazapine (3 mg/kg). Baseline V(d) ranged from 6 ml/ml in cerebellum to 18 ml/ml in frontal cortex, with some evidence for a small self-displaceable binding component in the cerebellum. Regional binding potentials (pBs) obtained by a constrained two-compartment model, using the V(d) observation in cerebellum, were consistently higher than pBs obtained by other arterial input or reference tissue methods. We found that adequate quantification of pB was obtained using the simplified reference tissue method. Concomitant PET studies with [(15)O]-water indicated that mirtazapine challenge increased CBF uniformly in cerebellum and other brain regions, supporting the use of this reference tissue for calculation of [(11)C]mirtazapine pB. Displacement by mirtazapine was complete in the cerebral cortex, but only 50% in diencephalon, suggesting the presence of multiple binding sites of differing affinities in that tissue. Competition studies with yohimbine and RX 821002 showed decreases in [(11)C]mirtazapine pB throughout the forebrain; use of the multireceptor version of the Michaelis-Menten equation indicated that 42% of [(11)C]mirtazapine binding in cortical regions is displaceable by yohimbine. Thus, PET studies confirm that [(11)C]mirtazapine affects alpha(2)-adrenoceptor binding sites in living brain. (c) 2006 Wiley-Liss, Inc.

  20. Mouse Polyomavirus Enters Early Endosomes, Requires Their Acidic pH for Productive Infection, and Meets Transferrin Cargo in Rab11-Positive Endosomes

    PubMed Central

    Liebl, David; Difato, Francesco; Horníková, Lenka; Mannová, Petra; Štokrová, Jitka; Forstová, Jitka

    2006-01-01

    Mouse polyomavirus (PyV) virions enter cells by internalization into smooth monopinocytic vesicles, which fuse under the cell membrane with larger endosomes. Caveolin-1 was detected on monopinocytic vesicles carrying PyV particles in mouse fibroblasts and epithelial cells (33). Here, we show that PyV can be efficiently internalized by Jurkat cells, which do not express caveolin-1 and lack caveolae, and that overexpression of a caveolin-1 dominant-negative mutant in mouse epithelial cells does not prevent their productive infection. Strong colocalization of VP1 with early endosome antigen 1 (EEA1) and of EEA1 with caveolin-1 in mouse fibroblasts and epithelial cells suggests that the monopinocytic vesicles carrying the virus (and vesicles containing caveolin-1) fuse with EEA1-positive early endosomes. In contrast to SV40, PyV infection is dependent on the acidic pH of endosomes. Bafilomycin A1 abolished PyV infection, and an increase in endosomal pH by NH4Cl markedly reduced its efficiency when drugs were applied during virion transport towards the cell nucleus. The block of acidification resulted in the retention of a fraction of virions in early endosomes. To monitor further trafficking of PyV, we used fluorescent resonance energy transfer (FRET) to determine mutual localization of PyV VP1 with transferrin and Rab11 GTPase at a 2- to 10-nm resolution. Positive FRET between PyV VP1 and transferrin cargo and between PyV VP1 and Rab11 suggests that during later times postinfection (1.5 to 3 h), the virus meets up with transferrin in the Rab11-positive recycling endosome. These results point to a convergence of the virus and the cargo internalized by different pathways in common transitional compartments. PMID:16611921

  1. 50 CFR 11.11 - Notice of violation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., POSSESSION, TRANSPORTATION, SALE, PURCHASE, BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS CIVIL PROCEDURES Assessment Procedure § 11.11 Notice of violation. (a) A notice of violation (hereinafter “notice... requested, upon the person believed to be subject to a civil penalty (the respondent). The notice shall...

  2. 50 CFR 11.11 - Notice of violation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., POSSESSION, TRANSPORTATION, SALE, PURCHASE, BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS CIVIL PROCEDURES Assessment Procedure § 11.11 Notice of violation. (a) A notice of violation (hereinafter “notice... requested, upon the person believed to be subject to a civil penalty (the respondent). The notice shall...

  3. Quantitative analysis of external limiting membrane, ellipsoid zone and interdigitation zone defects in patients with macular holes.

    PubMed

    Houly, Jacques Ramos; Veloso, Carlos Eduardo; Passos, Elke; Nehemy, Márcio Bittar

    2017-07-01

    To investigate the correlation between the length of external limiting membrane (ELM), ellipsoid zone (EZ) and interdigitation zone (IZ) defects and visual prognosis in patients undergoing macular hole (MH) surgery, using spectral-domain optical coherence tomography (SD-OCT). This is a retrospective, consecutive, observational case series study. Fifty-two eyes of 52 patients with primary MH were evaluated. A quantitative analysis of ELM, EZ and IZ defects was performed preoperatively and at 3 and 6 months postoperatively using SD-OCT. The correlation between pre- and postoperative ELM, EZ and IZ defects and the best-corrected visual acuity (BCVA) was investigated. The lengths of ELM, EZ and IZ defects correlated significantly with BCVA in each study period (P < 0.001). Preoperative measures of these band defects were also associated with visual outcomes 3 and 6 months after surgery (P < 0.05). Considering all preoperative parameters, the length of the ELM defect was the factor most strongly correlated with BCVA at 6 months (β = 0.643, P < 0.012). The integrity of the ELM was the only factor significantly associated with BCVA at 6 months (β = 0.427; P = 0.004). The preoperative length of the ELM defect is the strongest predictor of visual acuity after MH surgery. Postoperative integrity of the ELM is significantly associated with visual restoration after surgical treatment of MH.

  4. Electroexcitation of the Roper resonance for 1.7V2 in e→p→enπ+

    NASA Astrophysics Data System (ADS)

    Aznauryan, I. G.; Burkert, V. D.; Kim, W.; Park, K.; Adams, G.; Amaryan, M. J.; Ambrozewicz, P.; Anghinolfi, M.; Asryan, G.; Avakian, H.; Bagdasaryan, H.; Baillie, N.; Ball, J. P.; Baltzell, N. A.; Barrow, S.; Batourine, V.; Battaglieri, M.; Bedlinskiy, I.; Bektasoglu, M.; Bellis, M.; Benmouna, N.; Berman, B. L.; Biselli, A. S.; Blaszczyk, L.; Bonner, B. E.; Bookwalter, C.; Bouchigny, S.; Boiarinov, S.; Bradford, R.; Branford, D.; Briscoe, W. J.; Brooks, W. K.; Bültmann, S.; Butuceanu, C.; Calarco, J. R.; Careccia, S. L.; Carman, D. S.; Casey, L.; Cazes, A.; Chen, S.; Cheng, L.; Cole, P. L.; Collins, P.; Coltharp, P.; Cords, D.; Corvisiero, P.; Crabb, D.; Crede, V.; Cummings, J. P.; Dale, D.; Dashyan, N.; de Masi, R.; de Vita, R.; de Sanctis, E.; Degtyarenko, P. V.; Denizli, H.; Dennis, L.; Deur, A.; Dhamija, S.; Dharmawardane, K. V.; Dhuga, K. S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Donnelly, J.; Doughty, D.; Dugger, M.; Dytman, S.; Dzyubak, O. P.; Egiyan, H.; Egiyan, K. S.; Fassi, L. El; Elouadrhiri, L.; Eugenio, P.; Fatemi, R.; Fedotov, G.; Feldman, G.; Feuerbach, R. J.; Forest, T. A.; Fradi, A.; Funsten, H.; Gabrielyan, M. Y.; Garçon, M.; Gavalian, G.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Gohn, W.; Golovatch, E.; Gonenc, A.; Gordon, C. I. O.; Gothe, R. W.; Graham, L.; Griffioen, K. A.; Guidal, M.; Guillo, M.; Guler, N.; Guo, L.; Gyurjyan, V.; Hadjidakis, C.; Hafidi, K.; Hafnaoui, K.; Hakobyan, H.; Hakobyan, R. S.; Hanretty, C.; Hardie, J.; Hassall, N.; Heddle, D.; Hersman, F. W.; Hicks, K.; Hleiqawi, I.; Holtrop, M.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Ito, M. M.; Jenkins, D.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Juengst, H. G.; Kalantarians, N.; Keller, D.; Kellie, J. D.; Khandaker, M.; Kim, K. Y.; Klein, A.; Klein, F. J.; Klimenko, A. V.; Kossov, M.; Krahn, Z.; Kramer, L. H.; Kubarovsky, V.; Kuhn, J.; Kuhn, S. E.; Kuleshov, S. V.; Kuznetsov, V.; Lachniet, J.; Laget, J. M.; Langheinrich, J.; Lawrence, D.; Lee, T.; Li, Ji; Lima, A. C. S.; Livingston, K.; Lu, H. Y.; Lukashin, K.; MacCormick, M.; Markov, N.; Mattione, P.; McAleer, S.; McKinnon, B.; McNabb, J. W. C.; Mecking, B. A.; Mehrabyan, S.; Melone, J. J.; Mestayer, M. D.; Meyer, C. A.; Mibe, T.; Mikhailov, K.; Minehart, R.; Mirazita, M.; Miskimen, R.; Mokeev, V.; Morand, L.; Moreno, B.; Moriya, K.; Morrow, S. A.; Moteabbed, M.; Mueller, J.; Munevar, E.; Mutchler, G. S.; Nadel-Turonski, P.; Nasseripour, R.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niczyporuk, B. B.; Niroula, M. R.; Niyazov, R. A.; Nozar, M.; O'Rielly, G. V.; Osipenko, M.; Ostrovidov, A. I.; Park, S.; Pasyuk, E.; Paterson, C.; Pereira, S. Anefalos; Philips, S. A.; Pierce, J.; Pivnyuk, N.; Pocanic, D.; Pogorelko, O.; Polli, E.; Popa, I.; Pozdniakov, S.; Preedom, B. M.; Price, J. W.; Prok, Y.; Protopopescu, D.; Qin, L. M.; Raue, B. A.; Riccardi, G.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Rowntree, D.; Rubin, P. D.; Sabatié, F.; Saini, M. S.; Salamanca, J.; Salgado, C.; Santoro, J. P.; Sapunenko, V.; Schott, D.; Schumacher, R. A.; Serov, V. S.; Sharabian, Y. G.; Sharov, D.; Shaw, J.; Shvedunov, N. V.; Skabelin, A. V.; Smith, E. S.; Smith, L. C.; Sober, D. I.; Sokhan, D.; Stavinsky, A.; Stepanyan, S. S.; Stepanyan, S.; Stokes, B. E.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Suleiman, R.; Taiuti, M.; Takeuchi, T.; Tedeschi, D. J.; Tkabladze, A.; Tkachenko, S.; Todor, L.; Tur, C.; Ungaro, M.; Vineyard, M. F.; Vlassov, A. V.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Williams, M.; Wolin, E.; Wood, M. H.; Yegneswaran, A.; Yun, J.; Yurov, M.; Zana, L.; Zhang, B.; Zhang, J.; Zhao, B.; Zhao, Z. W.

    2008-10-01

    The helicity amplitudes of the electroexcitation of the Roper resonance are extracted for 1.7V2 from recent high precision JLab-CLAS cross section and longitudinally polarized beam asymmetry data for π+ electroproduction on protons at W=1.15-1.69 GeV. The analysis is made using two approaches, dispersion relations and a unitary isobar model, which give consistent Q2 behavior of the helicity amplitudes for the γ*p→N(1440)P11 transition. It is found that the transverse helicity amplitude A1/2, which is large and negative at Q2=0, becomes large and positive at Q2≃2GeV2, and then drops slowly with Q2. The longitudinal helicity amplitude S1/2, which was previously found from CLAS e→p→epπ0,enπ+ data to be large and positive at Q2=0.4,0.65GeV2, drops with Q2. Available model predictions for γ*p→N(1440)P11 allow us to conclude that these results provide strong evidence in favor of N(1440)P11 as a first radial excitation of the 3q ground state. The results of the present paper also confirm the conclusion of our previous analysis for Q2<1 GeV2 that the presentation of N(1440)P11 as a qG3 hybrid state is ruled out.

  5. Femtosecond time-resolved MeV electron diffraction

    DOE PAGES

    Zhu, Pengfei; Zhu, Y.; Hidaka, Y.; ...

    2015-06-02

    We report the experimental demonstration of femtosecond electron diffraction using high-brightness MeV electron beams. High-quality, single-shot electron diffraction patterns for both polycrystalline aluminum and single-crystal 1T-TaS 2 are obtained utilizing a 5 fC (~3 × 10 4 electrons) pulse of electrons at 2.8 MeV. The high quality of the electron diffraction patterns confirms that electron beam has a normalized emittance of ~50 nm rad. The transverse and longitudinal coherence length is ~11 and ~2.5 nm, respectively. The timing jitter between the pump laser and probe electron beam was found to be ~100 fs (rms). The temporal resolution is demonstrated bymore » observing the evolution of Bragg and superlattice peaks of 1T-TaS 2 following an 800 nm optical pump and was found to be 130 fs. Lastly, our results demonstrate the advantages of MeV electrons, including large elastic differential scattering cross-section and access to high-order reflections, and the feasibility of ultimately realizing below 10 fs time-resolved electron diffraction.« less

  6. The X11L/X11{beta}/MINT2 and X11L2/X11{gamma}/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sumioka, Akio; Saito, Yuhki; Sakuma, Megumi

    2008-03-10

    The X11/MINT family proteins are adaptor scaffolding proteins involved in formation of multiprotein complexes, and trafficking and metabolism of membrane proteins such as the beta-amyloid precursor protein. We found that a significant portion of X11L and X11L2 are recovered in nuclear fraction of mouse brain homogenates. EGFP-X11s were not detected in the nucleus of N2a neuroblastoma cells; however, administration of leptomycin B (LMB) induced substantial nuclear accumulation of EGFP-X11L and EGFP-X11L2, while EGFP-X11 showed little accumulation. Fluorescence loss in photobleaching (FLIP) analysis indicated that EGFP-X11L2 and EGFP-X11L are shuttled between the cytoplasm and nucleus, the former more effectively than themore » latter. We identified a nuclear export signal (NES) in the N-terminus of X11L2, mutation of which induces nuclear accumulation of EGFP-X11L2 in the absence of LMB. X11L2 fused to the Gal4 DNA binding domain (DBD) showed transcriptional activity, suggesting that X11L2 could function as a transcriptional activator if tethered near a promoter. Interestingly, attenuation of the nucleo-cytoplasmic shuttling of GAL4-DBD-X11L2 by mutating the NES or attaching the SV40 nuclear localization signal significantly decreased the apparent transcriptional activity. Our observations suggest that X11L2 functions in the nucleus by a mechanism distinct from conventional transactivators.« less

  7. Impact of the diagnostic changes to post-traumatic stress disorder for DSM-5 and the proposed changes to ICD-11.

    PubMed

    O'Donnell, Meaghan L; Alkemade, Nathan; Nickerson, Angela; Creamer, Mark; McFarlane, Alexander C; Silove, Derrick; Bryant, Richard A; Forbes, David

    2014-09-01

    There have been changes to the criteria for diagnosing post-traumatic stress disorder (PTSD) in DSM-5 and changes are proposed for ICD-11. To investigate the impact of the changes to diagnostic criteria for PTSD in DSM-5 and the proposed changes in ICD-11 using a large multisite trauma-exposed sample and structured clinical interviews. Randomly selected injury patients admitted to four hospitals were assessed 72 months post trauma (n = 510). Structured clinical interviews for PTSD and major depressive episode, as well as self-report measures of disability and quality of life were administered. Current prevalence of PTSD under DSM-5 scoring was not significantly different from DSM-IV (6.7% v. 5.9%, z = 0.53, P = 0.59). However, the ICD-11 prevalence was significantly lower than ICD-10 (3.3% v. 9.0%, z = -3.8, P<0.001). The PTSD current prevalence was significantly higher for DSM-5 than ICD-11 (6.7% v. 3.3%, z = 2.5, P = 0.01). Using ICD-11 tended to show lower rates of comorbidity with depression and a slightly lower association with disability. The diagnostic systems performed in different ways in terms of current prevalence rates and levels of comorbidity with depression, but on other broad key indicators they were relatively similar. There was overlap between those with PTSD diagnosed by ICD-11 and DSM-5 but a substantial portion met one but not the other set of criteria. This represents a challenge for research because the phenotype that is studied may be markedly different according to the diagnostic system used. Royal College of Psychiatrists.

  8. The ep -->e'p eta reaction at and above the S11(1535) baryon resonance.

    PubMed

    Thompson, R; Dytman, S; Kim, K Y; Mueller, J; Adams, G S; Amaryan, M J; Anciant, E; Anghinolfi, M; Asavapibhop, B; Auger, T; Audit, G; Avakian, H; Barrow, S; Battaglieri, M; Beard, K; Bektasoglu, M; Bertozzi, W; Bianchi, N; Biselli, A; Boiarinov, S; Bonner, B E; Briscoe, W J; Brooks, W; Burkert, V D; Calarco, J R; Capitani, G; Carman, D S; Carnahan, B; Cole, P L; Coleman, A; Connelly, J; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Cummings, J; Day, D; Degtyarenko, P V; Demirchyan, R A; Dennis, L C; Deppman, A; De Sanctis, E; De Vita, R; Dhuga, K S; Djalali, C; Dodge, G E; Doughty, D; Dragovitsch, P; Dugger, M; Eckhause, M; Efremenko, Y V; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Farhi, L; Feuerbach, R J; Ficenec, J; Fissum, K; Freyberger, A; Funsten, H; Gai, M; Gavrilov, V B; Gilfoyle, G P; Giovanetti, K; Gilad, S; Girard, P; Griffioen, K A; Guidal, M; Guillo, M; Gyurjyan, V; Hancock, D; Hardie, J; Heddle, D; Heisenberg, J; Hersman, F W; Hicks, K; Hicks, R S; Holtrop, M; Hyde-Wright, C E; Ito, M M; Jenkins, D; Joo, K; Kane, J; Khandaker, M; Kim, W; Klein, A; Klein, F J; Klusman, M; Kossov, M; Kuhn, S E; Kuang, Y; Laget, J M; Lawrence, D; Leskin, G A; Longhi, A; Loukachine, K; Lucas, M; Magahiz, R; Major, R W; Manak, J J; Marchand, C; Matthews, S K; McAleer, S; McCarthy, J; McNabb, J W; Mecking, B A; Mestayer, M D; Meyer, C A; Minehart, R; Mirazita, M; Miskimen, R; Muccifora, V; Mutchler, G S; Napolitano, J; Niyazov, R A; Ohandjanyan, M S; O'Brien, J T; Opper, A; Patois, Y; Peterson, G A; Philips, S; Pivnyuk, N; Pocanic, D; Pogorelko, O; Polli, E; Preedom, B M; Price, J W; Qin, L M; Raue, B A; Reolon, A R; Riccardi, G; Ricco, G; Ripani, M; Ritchie, B G; Ronchetti, F; Rossi, P; Roudot, F; Rowntree, D; Rubin, P D; Salgado, C W; Sanzone, M; Sapunenko, V; Sarty, A; Sargsyan, M; Schumacher, R A; Shafi, A; Sharabian, Y G; Shaw, J; Shuvalov, S M; Skabelin, A; Smith, T; Smith, C; Smith, E S; Sober, D I; Spraker, M; Stepanyan, S; Stoler, P; Taiuti, M; Taylor, S; Tedeschi, D; Tung, T Y; Vineyard, M F; Vlassov, A; Weller, H; Weinstein, L B; Welsh, R; Weygand, D P; Whisnant, S; Witkowski, M; Wolin, E; Yegneswaran, A; Yun, J; Zhou, Z; Zhao, J

    2001-02-26

    New cross sections for the reaction e p-->e p eta are reported for total center of mass energy W = 1.5--1.86 GeV and invariant momentum transfer Q2 = 0.25--1.5 (GeV/c)(2). This large kinematic range allows extraction of important new information about response functions, photocouplings, and eta N coupling strengths of baryon resonances. Newly observed structure at W approximately 1.65 GeV is shown to come from interference between S and P waves and can be interpreted with known resonances. Improved values are derived for the photon coupling amplitude for the S11(1535) resonance.

  9. Bilateral comparison of 10 V standards between the NSAI-NML (Ireland) and the BIPM, February to March 2012 (part of the ongoing BIPM key comparison BIPM.EM-K11.b)

    NASA Astrophysics Data System (ADS)

    Power, O.; Solve, S.; Chayramy, R.; Stock, M.

    2012-01-01

    As part of the on-going BIPM key comparison BIPM.EM-K11.b, a comparison of the 10 V voltage reference standards of the BIPM and the National Standards Authority of Ireland-National Metrology Laboratory (NSAI-NML), Dublin, Ireland, was carried out from February to March 2012. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPM_C (ZC) and BIPM_D (ZD), were transported by freight to NSAI-NML. At NSAI-NML, the reference standard for DC voltage at the 10 V level consists of a group of characterized Zener diode-based electronic voltage standards. The output EMF (electromotive force) of each travelling standard was measured by direct comparison with the group standard. At the BIPM the travelling standards were calibrated, before and after the measurements at NSAI-NML, with the Josephson voltage standard. Results of all measurements were corrected for the dependence of the output voltages on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the value assigned to DC voltage standard by NSAI-NML, at the level of 10 V, at NSAI-NML, UNML, and that assigned by the BIPM, at the BIPM, UBIPM, at the reference date of 23 February 2012. UNML - UBIPM = +0.83 µV, uc = 1.35 µV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NSAI-NML, based on KJ-90, and the uncertainty related to the comparison. The final result is impacted by the anomalous offset between the NSAI-NML results for the two transfer standards. The reason for this offset hasn't been determined. However, the difference remains within the total combined standard uncertainty. Therefore, the comparison result shows that the voltage standards maintained by NSAI-NML and the BIPM were equivalent, within their stated expanded uncertainties, on the mean date of the comparison. Main text. To reach the main text of

  10. V&V Within Reuse-Based Software Engineering

    NASA Technical Reports Server (NTRS)

    Addy, Edward A.

    1996-01-01

    Verification and Validation (V&V) is used to increase the level of assurance of critical software, particularly that of safety-critical and mission-critical software. V&V is a systems engineering discipline that evaluates the software in a systems context, and is currently applied during the development of a specific application system. In order to bring the effectiveness of V&V to bear within reuse-based software engineering, V&V must be incorporated within the domain engineering process.

  11. V & V Within Reuse-Based Software Engineering

    NASA Technical Reports Server (NTRS)

    Addy, Edward A.

    1996-01-01

    Verification and validation (V&V) is used to increase the level of assurance of critical software, particularly that of safety-critical and mission critical software. This paper describes the working group's success in identifying V&V tasks that could be performed in the domain engineering and transition levels of reuse-based software engineering. The primary motivation for V&V at the domain level is to provide assurance that the domain requirements are correct and that the domain artifacts correctly implement the domain requirements. A secondary motivation is the possible elimination of redundant V&V activities at the application level. The group also considered the criteria and motivation for performing V&V in domain engineering.

  12. Word Frequency Analysis MOS: 11H. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    I k,4 L t qs 1’ F £U 19 L ’A T 19 5 S r4 19 SQUARE I 1 I i f1 ,41 0 ItLf tD ;- 1 ASSEMBLY ILtl LI’IC 0 iA!,A (.E laID Is EVERY T IC :,.% .IMUtl I nXT...1iwl15ll’G 2 1 ULEUTLR 2 uORtRNfC 2 ’L’ i ,T,.10 2 L 4:.E/14JSH 2p Ls , 01 -.A’LM NT 2 L:’ ZfOET t Te 2~ LI V1 2AL 2 L- E1𔄃TLC2 LA 2 -i’ A JAJ , At 2...11 9 .4’? S ~P ’~II9 1.$ S3 C,: y.T! ON 1; 1 LT 1:1:%L r c " tD S; FI IL 9 1,0q 9 Pq 1 !’. 9 rrInT P. ’"JlLL0 1;1 9; k.I..) J I Ptr1.CS I 9 t,! ’U1E

  13. Some Problems of Morphology in the Light of V. I. Lenin’s Work ’Materialism and Empiriocriticism’

    DTIC Science & Technology

    1960-09-28

    energy theory of F. Engels (V. P. Bunak, M. A. Gremyat- skiy, V. V. Ginzburg, etc.). - 11 - In the field of human anatomy , a marked idealistic...viere in the field of human anatomy — in particular in the anatomy of the lymphatic system — Soviet anatomists cannot share the finalistic form of

  14. Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the KCNH2-Encoded Kv11.1 Channel.

    PubMed

    Smith, Jennifer L; Tester, David J; Hall, Allison R; Burgess, Don E; Hsu, Chun-Chun; Claude Elayi, Samy; Anderson, Corey L; January, Craig T; Luo, Jonathan Z; Hartzel, Dustin N; Mirshahi, Uyenlinh L; Murray, Michael F; Mirshahi, Tooraj; Ackerman, Michael J; Delisle, Brian P

    2018-05-01

    Heterologous functional validation studies of putative long-QT syndrome subtype 2-associated variants clarify their pathological potential and identify disease mechanism(s) for most variants studied. The purpose of this study is to clarify the pathological potential for rare nonsynonymous KCNH2 variants seemingly associated with sudden infant death syndrome. Genetic testing of 292 sudden infant death syndrome cases identified 9 KCNH2 variants: E90K, R181Q, A190T, G294V, R791W, P967L, R1005W, R1047L, and Q1068R. Previous studies show R181Q-, P967L-, and R1047L-Kv11.1 channels function similar to wild-type Kv11.1 channels, whereas Q1068R-Kv11.1 channels accelerate inactivation gating. We studied the biochemical and biophysical properties for E90K-, G294V-, R791W-, and R1005W-Kv11.1 channels expressed in human embryonic kidney 293 cells; examined the electronic health records of patients who were genotype positive for the sudden infant death syndrome-linked KCNH2 variants; and simulated their functional impact using computational models of the human ventricular action potential. Western blot and voltage-clamping analyses of cells expressing E90K-, G294V-, R791W-, and R1005W-Kv11.1 channels demonstrated these variants express and generate peak Kv11.1 current levels similar to cells expressing wild-type-Kv11.1 channels, but R791W- and R1005W-Kv11.1 channels accelerated deactivation and activation gating, respectively. Electronic health records of patients with the sudden infant death syndrome-linked KCNH2 variants showed that the patients had median heart rate-corrected QT intervals <480 ms and none had been diagnosed with long-QT syndrome or experienced cardiac arrest. Simulating the impact of dysfunctional gating variants predicted that they have little impact on ventricular action potential duration. We conclude that these rare Kv11.1 missense variants are not long-QT syndrome subtype 2-causative variants and therefore do not represent the pathogenic substrate for

  15. Visuomotor Performance in KCNJ11-Related Neonatal Diabetes Is Impaired in Children With DEND-Associated Mutations and May Be Improved by Early Treatment With Sulfonylureas

    PubMed Central

    Shah, Reshma P.; Spruyt, Karen; Kragie, Brigette C.; Greeley, Siri Atma W.; Msall, Michael E.

    2012-01-01

    OBJECTIVE To assess performance on an age-standardized neuromotor coordination task among sulfonylurea-treated KCNJ11-related neonatal diabetic patients. RESEARCH DESIGN AND METHODS Nineteen children carrying KCNJ11 mutations associated with isolated diabetes (R201H; n = 8), diabetes with neurodevelopmental impairment (V59M or V59A [V59M/A]; n = 8), or diabetes not consistently associated with neurodevelopmental disability (Y330C, E322K, or R201C; n = 3) were studied using the age-standardized Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI). RESULTS Although R201H subjects tested in the normal range (median standard score = 107), children with V59M/A mutations had significantly lower than expected VMI standard scores (median = 49). The scores for all three groups were significantly different from each other (P = 0.0017). The age of sulfonylurea initiation was inversely correlated with VMI scores in the V59M/A group (P < 0.05). CONCLUSIONS Neurodevelopmental disability in KCNJ11-related diabetes includes visuomotor problems that may be ameliorated by early sulfonylurea treatment. Comprehensive longitudinal assessment on larger samples will be imperative. PMID:22855734

  16. Permeation of deuterium implanted into V-15Cr-5Ti

    NASA Astrophysics Data System (ADS)

    Anderl, R. A.; Longhurst, G. R.; Struttmann, D. A.

    1987-02-01

    Permeation and reemission of deuterium for the vanadium alloy, V-15Cr-5Ti, was investigated using 3 keV, D 3+ ion beams from a small accelerator. The experiments consisted of measurement of the deuterium reemission and permeation rates as a function of implantation fluence for 0.5 mm thick specimens heated to temperatures from 623 K to 823 K. Implantation-side surface characterization was made by simultaneous measurements of sputtered ions with a secondary ion mass spectrometer (SIMS). For the experimental conditions used, the steady-state deuterium permeation flux in V-15Cr-5Ti is approximately 18% of the implantation flux. This is approximately 1000 times that seen in the austenitic stainless steel, PCA, and 200 times that seen in the ferritic steel, HT-9, under comparable conditions. Measurement of deuterium diffusivity in V-15Cr-5Ti using permeation break-through times indicates that D = 1.4 × 10 -8 exp( -0.11 eV/ kT) (m 2/s), over the temperature range 723 K to 823 K.

  17. CERT Resilience Management Model Capability Appraisal Method (CAM) Version 1.1

    DTIC Science & Technology

    2011-10-01

    the CERT-RMM CAM V1.1 method is that satisfaction of goals can be determined only upon detailed investigation of the extent to which each...achievement of a specific maturity level or the satisfaction of a process area must mean the same thing for different appraised organizations. The...rate the satisfaction of the goals, based on the extent of practice implementation, for the appraisal reference model and organizational scope

  18. Charge topology of the coherent dissociation of relativistic 11C and 12N nuclei

    NASA Astrophysics Data System (ADS)

    Artemenkov, D. A.; Bradnova, V.; Zaitsev, A. A.; Zarubin, P. I.; Zarubina, I. G.; Kattabekov, R. R.; Kornegrutsa, N. K.; Mamatkulov, K. Z.; Rukoyatkin, P. A.; Rusakova, V. V.; Stanoeva, R.

    2015-09-01

    The charge topology of coherent-dissociation events is presented for 11С and 12N nuclei of energy 1.2 GeV per nucleon bombarding nuclear track emulsions. This topology is compared with respective data for 7Be, 8,10B, 9,10C, and 14N nuclei.

  19. Beam line BL11 for LIGA process at the NewSUBARU

    NASA Astrophysics Data System (ADS)

    Mekaru, Harutaka; Utsumi, Yuichi; Hattori, Tadashi

    2001-07-01

    A beam line BL11 is constructed for exposure Hard X-ray Lithography (HXL) in the LIGA (German acronym for Lithographite Galvanoformung and Abformung) process at the synchrotron radiation (SR) facility NewSUBARU of the Laboratory of Advanced Science and Technology for Industry (LASTI) in Himeji Institute of Technology (HIT). This beam line was designed by the criteria; photon energy range 4-6 keV, a beam spot size on the exposure stage ⩾60×5 mm 2, a density of total irradiated photons ⩾10 11 photons/cm 2. The PMMA sheet etching was successfully demonstrated by using the output beam. We conclude that this beam line performs sufficiently well to study the exposure of HXL in the LIGA process.

  20. Use of biomarkers in resident organisms as a tool for environmental monitoring in a cold coastal system, Tierra del Fuego Island.

    PubMed

    Comoglio, L; Amin, O; Botté, S; Marcovecchio, J

    2011-03-01

    Antioxidant status of Nacella (P) magellanica and Mytilus edulis related with heavy metal in sediment and tissues were analysed in five stations close to Ushuaia city in winter and spring. The principal component analysis produced a two-dimensional pattern of the degree of similarity between sites. The Industrial-Urban Contamination Index (IUCI) showed that the Industrial Zone (IZ) and Oil Marine Station (OMS) represent areas with anthropic inputs. Heavy metals have differential association with biomarkers depending on the species. In limpets, digestive gland presented major activities of enzyme defence in winter and gonads have shown higher values of Catalase (CAT) during spring while lipid peroxidation (LPO) presented higher values in IZ. For mussels CAT and LPO increased in spring time. For superoxide dismutase (SOD) peaks have been detected in IZ and NW stations for winter. Differences in biomarker responses due to seasons did not influence the grouping of the sites into references and contaminated groups. Copyright © 2010 Elsevier Inc. All rights reserved.

  1. Absorption coefficients of CFC-11 and CFC-12 needed for atmospheric remote sensing and global warming studies

    NASA Technical Reports Server (NTRS)

    Varanasi, Prasad

    1992-01-01

    Spectral absorption coefficients k(v) in the atmospheric window are reported for CFC-11 and CFC-12. Data obtained with a grating spectrometer are compared with NCAR cross sections and measurements of k(v) made with a tunable diode laser spectrometer at various temperature-pressure combinations representing tangent heights or layers in the atmosphere are presented. The results are suitable for atmospheric remote sensing and global warming studies.

  2. Re-engineering Cytochrome P450 2B11dH for Enhanced Metabolism of Several Substrates Including the Anti-cancer Prodrugs Cyclophosphamide and Ifosfamide

    PubMed Central

    Sun, Ling; Chen, Chong S.; Waxman, David J.; Liu, Hong; Halpert, James R.; Kumar, Santosh

    2007-01-01

    Based on recent directed evolution of P450 2B1, six P450 2B11 mutants at three positions were created in an N-terminal modified construct termed P450 2B11dH and characterized for enzyme catalysis using five substrates. Mutant I209A demonstrated a 3.2-fold enhanced kcat/Km for 7-ethoxy-4-trifluoromethylcourmarin O-deethylation, largely due to a dramatic decrease in Km (0.72 vs. 18 μM). I209A also demonstrated enhanced selectivity for testosterone 16β-hydroxylation over 16α-hydroxylation. In contrast, V183L showed a 4-fold increased kcat for 7-benzyloxyresorufin debenzylation and a 4.7-fold increased kcat/Km for testosterone 16α-hydroxylation. V183L also displayed a 1.7-fold higher kcat/Km than P450 2B11dH with the anti-cancer prodrugs cyclophosphamide and ifosfamide, resulting from a ~4-fold decrease in Km. Introduction of the V183L mutation into full-length P450 2B11 did not enhance the kcat/Km. Overall, the re-engineered P450 2B11dH enzymes exhibited enhanced catalytic efficiency with several substrates including the anti-cancer prodrugs. PMID:17254539

  3. Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors

    PubMed Central

    Horvath, Anelia; Korde, Larissa; Greene, Mark H.; Libe, Rosella; Osorio, Paulo; Faucz, Fabio Rueda; Raffin-Sanson, Marie Laure; Tsang, Kit Man; Drori-Herishanu, Limor; Patronas, Yianna; Remmers, Elaine F; Nikita, Maria-Elena; Moran, Jason; Greene, Joseph; Nesterova, Maria; Merino, Maria; Bertherat, Jerome; Stratakis, Constantine A.

    2009-01-01

    Inactivating germline mutations in phosphodiesterase 11A (PDE11A) have been implicated in adrenal tumor susceptibility. PDE11A is highly-expressed in endocrine steroidogenic tissues, especially the testis, and mice with inactivated Pde11a exhibit male infertility, a known testicular germ cell tumor (TGCT) risk factor. We sequenced the PDE11A gene-coding region in 95 patients with TGCT from 64 unrelated kindreds. We identified 8 non-synonymous substitutions in 20 patients from 15 families: four (R52T; F258Y; G291R; V820M) were newly-recognized, three (R804H; R867G; M878V) were functional variants previously implicated in adrenal tumor predisposition, and one (Y727C) was a known polymorphism. We compared the frequency of these variants in our patients to unrelated controls that had been screened and found negative for any endocrine diseases: only the two previously-reported variants, R804H and R867G, known to be frequent in general population, were detected in these controls. The frequency of all PDE11A-gene variants (combined) was significantly higher among patients with TGCT (P=0.0002), present in 19% of the families of our cohort. Most variants were detected in the general population, but functional studies showed that all these mutations reduced PDE activity, and that PDE11A protein expression was decreased (or absent) in TGCT samples from carriers. This is the first demonstration of a PDE gene’s involvement in TGCT, although the cAMP signaling pathway has been investigated extensively in other reproductive organs and their diseases. In conclusion, we report that PDE11A-inactivating sequence variants may modify the risk of familial and bilateral TGCT. PMID:19549888

  4. Cloning and expression analysis of CaPIP1-1 gene in pepper (Capsicum annuum L.).

    PubMed

    Yin, Yan-Xu; Wang, Shu-Bin; Zhang, Huai-Xia; Xiao, Huai-Juan; Jin, Jing-Hao; Ji, Jiao-Jiao; Jing, Hua; Chen, Ru-Gang; Arisha, Mohamed Hamed; Gong, Zhen-Hui

    2015-05-25

    Plant aquaporins are responsible for water transmembrane transport, which play an important role on abiotic and biotic stresses. A novel plasma membrane intrinsic protein of CaPIP1-1 was isolated from the pepper P70 according to transcriptome databases of Phytophthora capsici inoculation and chilling stress library. CaPIP1-1, which is 1155 bp in length with an open reading frame of 861 bp, encoded 286 amino acids. Three introns, exhibited CT/AC splice junctions, were observed in CaPIP1-1. The numbers and location of introns in CaPIP1-1 were the same as observed in tomato and potato. CaPIP1-1 was abundantly expressed in pepper fruit. Increased transcription levels of CaPIP1-1 were found in the different stresses, including chilling stress, salt stress, mannitol stress, salicylic acid, ABA treatment and Phytophthora capsici infection. The expression of CaPIP1-1 was downregulated by 50 μM HgCl2 and 100 μM fluridone. The pepper plants silenced CaPIP1-1 in cv. Qiemen showed growth inhibition and decreased tolerance to salt and mannitol stresses using detached leaf method. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Are [O-methyl-11C]derivatives of ICI 89,406 beta1-adrenoceptor selective radioligands suitable for PET?

    PubMed

    Law, Marilyn P; Wagner, Stefan; Kopka, Klaus; Pike, Victor W; Schober, Otmar; Schäfers, Michael

    2008-01-01

    Radioligand binding studies show that beta(1)-adrenoceptor (beta(1)-AR) density may be reduced in heart disease without down regulation of beta(2)-ARs. Radioligands are available for measuring total beta-AR density non-invasively with clinical positron emission tomography (PET) but none are selective for beta(1)- or beta(2)-ARs. The aim was to evaluate ICI 89,406, a beta(1)-AR-selective antagonist amenable to labelling with positron emitters, for PET. The S-enantiomer of an [O-methyl-(11)C] derivative of ICI 89,406 ((S)-[(11)C]ICI-OMe) was synthesised. Tissue radioactivity after i.v. injection of (S)-[(11)C]ICI-OMe (< 2 nmol x kg(-1)) into adult Wistar rats was assessed by small animal PET and post mortem dissection. Metabolism was assessed by HPLC of extracts prepared from plasma and tissues and by measuring [(11)C]CO(2) in exhaled air. The heart was visualised by PET after injection of (S)-[(11)C]ICI-OMe but neither unlabelled (S)-ICI-OMe nor propranolol (non-selective beta-AR antagonist) injected 15 min after (S)-[(11)C]ICI-OMe affected myocardial radioactivity. Ex vivo dissection showed that injecting unlabelled (S)-ICI-OMe, propranolol or CGP 20712A (beta(1)-selective AR antagonist) at high dose (> 2 mumol x kg(-1)) before (S)-[(11)C]ICI-OMe had a small effect on myocardial radioactivity. HPLC demonstrated that radioactivity in myocardium was due to unmetabolised (S)-[(11)C]ICI-OMe although (11)C-labelled metabolites rapidly appeared in plasma and liver and [(11)C]CO(2) was detected in exhaled air. Myocardial uptake of (S)-[(11)C]ICI-OMe after i.v. injection was low, possibly due to rapid metabolism in other tissues. Injection of unlabelled ligand or beta-AR antagonists had little effect indicating that binding was mainly to non-specific myocardial sites, thus precluding the use of (S)-[(11)C]ICI-OMe to assess beta(1)-ARs with PET.

  6. TeV electron measurement with CREST experiment

    NASA Astrophysics Data System (ADS)

    Park, Nahee; Anderson, T.; Bower, C.; Coutu, S.; Gennaro, J.; Geske, M.; Muller, D.; Musser, J.; Nutter, S.

    CREST, the Cosmic Ray Electron Synchrotron Telescope is a balloon-borne experiment de-signed to measure the spectrum of multi-TeV electrons by the detection of the x-ray synchrotron photons generated in the magnetic field of the Earth. Electrons in the TeV range are expected to reflect the properties of local sources because fluxes from remote locations are suppressed by radiative losses during propagation. Since CREST needs to intersect only a portion of the kilometers-long trail of photons generated by the high-energy electron, the method yields a larger effective area than the physical size of the detector, boosting detection areas. The in-strument is composed of an array of 1024 BaF2 crystals and a set of scintillating veto counters. A long duration balloon flight in Antarctica is currently planned for the 2010-11 season.

  7. USM3D Simulations of Saturn V Plume Induced Flow Separation

    NASA Technical Reports Server (NTRS)

    Deere, Karen; Elmlilgui, Alaa; Abdol-Hamid, K. S.

    2011-01-01

    The NASA Constellation Program included the Ares V heavy lift cargo vehicle. During the design stage, engineers questioned if the Plume Induced Flow Separation (PIFS) that occurred along Saturn V rocket during moon missions at some flight conditions, would also plague the newly proposed rocket. Computational fluid dynamics (CFD) was offered as a tool for initiating the investigation of PIFS along the Ares V rocket. However, CFD best practice guidelines were not available for such an investigation. In an effort to establish a CFD process and define guidelines for Ares V powered simulations, the Saturn V vehicle was used because PIFS flight data existed. The ideal gas, computational flow solver USM3D was evaluated for its viability in computing PIFS along the Saturn V vehicle with F-1 engines firing. Solutions were computed at supersonic freestream conditions, zero degree angle of attack, zero degree sideslip, and at flight Reynolds numbers. The effects of solution sensitivity to grid refinement, turbulence models, and the engine boundary conditions on the predicted PIFS distance along the Saturn V were discussed and compared to flight data from the Apollo 11 mission AS-506.

  8. Sensing Traffic Density Combining V2V and V2I Wireless Communications.

    PubMed

    Sanguesa, Julio A; Barrachina, Javier; Fogue, Manuel; Garrido, Piedad; Martinez, Francisco J; Cano, Juan-Carlos; Calafate, Carlos T; Manzoni, Pietro

    2015-12-16

    Wireless technologies are making the development of new applications and services in vehicular environments possible since they enable mobile communication between vehicles (V2V), as well as communication between vehicles and infrastructure nodes (V2I). Usually, V2V communications are dedicated to the transmission of small messages mainly focused on improving traffic safety. Instead, V2I communications allow users to access the Internet and benefit from higher level applications. The combination of both V2V and V2I, known as V2X communications, can increase the benefits even further, thereby making intelligent transportation systems (ITS) a reality. In this paper, we introduce V2X-d, a novel architecture specially designed to estimate traffic density on the road. In particular, V2X-d exploits the combination of V2V and V2I communications. Our approach is based on the information gathered by sensors (i.e., vehicles and road side units (RSUs)) and the characteristics of the roadmap topology to accurately make an estimation of the instant vehicle density. The combination of both mechanisms improves the accuracy and coverage area of the data gathered, while increasing the robustness and fault tolerance of the overall approach, e.g., using the information offered by V2V communications to provide additional density information in areas where RSUs are scarce or malfunctioning. By using our collaborative sensing scheme, future ITS solutions will be able to establish adequate dissemination protocols or to apply more efficient traffic congestion reduction policies, since they will be aware of the instantaneous density of vehicles.

  9. Sensing Traffic Density Combining V2V and V2I Wireless Communications

    PubMed Central

    Sanguesa, Julio A.; Barrachina, Javier; Fogue, Manuel; Garrido, Piedad; Martinez, Francisco J.; Cano, Juan-Carlos; Calafate, Carlos T.; Manzoni, Pietro

    2015-01-01

    Wireless technologies are making the development of new applications and services in vehicular environments possible since they enable mobile communication between vehicles (V2V), as well as communication between vehicles and infrastructure nodes (V2I). Usually, V2V communications are dedicated to the transmission of small messages mainly focused on improving traffic safety. Instead, V2I communications allow users to access the Internet and benefit from higher level applications. The combination of both V2V and V2I, known as V2X communications, can increase the benefits even further, thereby making intelligent transportation systems (ITS) a reality. In this paper, we introduce V2X-d, a novel architecture specially designed to estimate traffic density on the road. In particular, V2X-d exploits the combination of V2V and V2I communications. Our approach is based on the information gathered by sensors (i.e., vehicles and road side units (RSUs)) and the characteristics of the roadmap topology to accurately make an estimation of the instant vehicle density. The combination of both mechanisms improves the accuracy and coverage area of the data gathered, while increasing the robustness and fault tolerance of the overall approach, e.g., using the information offered by V2V communications to provide additional density information in areas where RSUs are scarce or malfunctioning. By using our collaborative sensing scheme, future ITS solutions will be able to establish adequate dissemination protocols or to apply more efficient traffic congestion reduction policies, since they will be aware of the instantaneous density of vehicles. PMID:26694405

  10. Casper to Dave Johnston 230-kV Transmission Line Project: Environmental assessment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1986-01-01

    Western proposes to reconstruct the existing Casper-Glendo North 115-kV Transmission Line to 230-kV between a point 1.1 miles northeast of the Pacific Power and Light (Pacific) Casper Substation and the Dave Johnston (DJ) Powerplant near Glenrock, Wyoming. As part of the proposed action, Western proposes to remove the portion of the existing Casper-Glendo South 115-kV Transmission Line between Western's Casper Substation and the intersection with the Casper-Glendo North Transmission Line, about 15 miles east of Casper. The removed portion of the Casper-Glendo North Transmission Line would be rebuilt on steel, single-shaft, structures. The section between the point northeast of themore » Pacific Substation and the intersection with the Casper-Glendo South Transmission Line would be double circuit (230-kV/115-kV). At the intersection of the north and south lines, the new 115-kV section would be tied to the remaining portion of the Casper-Glendo South Line to complete the 115-kV Casper-Glendo circuit. 52 refs.,12 figs., 14 tabs.« less

  11. Heat Transfer, Adiabatic Effectiveness and Injectant Distributions Downstream of Single Rows and Two Staggered Rows of Film-Cooling Holes with Simple and Compound Angles

    DTIC Science & Technology

    1991-12-01

    I~~.s~ -11 g~~u 0 Li o II >O Lr~ DJC): I-z 0( r- 4 LA- F. Lncn ~ n L-I- 168) " to Neem in in u zq sI 03*S .3 II to In I o I -1 - 0 - ’ -’𔃻. 169 1...H , 1 0 9,0 9.0 t’D Z0 ’ oiLs /i~s 179 C\\2 z 00 Ziin > W= 180 0 Q - C., 9 N 0 0I F-4~ H* 9,I- o * , Oj~s/,C 1810~ C’Q I IC O) E- C)- F-4 C/) Z

  12. Saipan and Joint Operations

    DTIC Science & Technology

    1990-02-12

    following postwar joint education objectives for ths armed forces: Objective i: To oroduce within each component of the armed forces a general knowledge...had acquired the pradtical knowledge to establieh::thvoe Joint educational goals which are as relevant today as when they were written. ENDNOTES 1...F2:", (- 1-1 1’A I’rn ,r’ lqA ,! Vim l ;` thO? C’~~~~~~~ a m in A i h9%t ý A din r, a INi m i t z% "h e haa I.z a:wn naval. +ac! lit! es, line~i n+f

  13. An Approach to Evaluation of Rural Development Act Title V Programs. Northeast Regional Center for Rural Development Publication 11, February 1976.

    ERIC Educational Resources Information Center

    Miller, Robert W.

    Presenting suggestions for conceptualizing Rural Development Act Title V program evaluations, this paper focuses upon a five-level program outcomes model which encompasses a causal sequence of anticipated shortrun, intermediate, and longrun outcomes. Examples of possible Title V measurement foci are presented for each of five outcome levels as…

  14. Microbial vanadium (V) reduction in groundwater with different soils from vanadium ore mining areas.

    PubMed

    Hao, Liting; Zhang, Baogang; Feng, Chuanping; Zhang, Zhenya; Lei, Zhongfang; Shimizu, Kazuya; Cao, Xuelong; Liu, Hui; Liu, Huipeng

    2018-07-01

    This work investigated the potential of vanadium (V) (V(V)) bioreduction by using soils sampled from four main kinds of vanadium ore mining areas, i.e. vanadium titanomagnetite, stone coal, petroleum associated minerals and uvanite as inocula. During a typical operation cycle of 60 h, the soils from vanadium titanomagnetite area and petroleum associated minerals area exhibited higher V(V) removal efficiencies, about 92.0 ± 2.0% and 91.0 ± 1.9% in comparison to 87.1 ± 1.9% and 69.0 ± 1.1% for the soils from uvanite and stone coal areas, respectively. Results from high-throughput 16 S rRNA gene pyrosequencing analysis reflect the accumulation of Bryobacter and Acidobacteriaceae with capabilities of V(V) reduction, accompanied with other functional species. This study is helpful to search new functional species for V(V) reduction and to develop in situ bioremediations of V(V) polluted groundwater. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Doping effect on charge ordering in the spinel compound AlV_2-xCr_xO_4

    NASA Astrophysics Data System (ADS)

    Horibe, Yoichi; Kurushima, Kosuke; Mori, Shigeo; Shingu, Masao; Katsufuji, Takuro

    2004-03-01

    It is reported that AlV_2O4 with the spinel-type structure shows the charge-ordering (CO) behavior below 700K.[1] Because the average valence of V is V^2.5+ in this compound, the CO structure is characterized by the unique CO pattern with V^2+:V^4+=3:1. In this talk, we will report doping effect on the CO structure in AlV_2O_4. In particular, we will focus on changes of microstructure related to the CO structure by Cr doping by transmission electron microscopy. Firstly we confirmed that AlV_2O4 has a long-ranged CO structure characterized by a single wave vector q=(1/2)[111]. On the other hand, we found the presence of diffuse scatterings at the (1/2)[111] and (1/2)[1-11]-type positions in AlV_1.875Cr_0.125O4 at room temperature. This means that the CO structure in AlV_1.875Cr_0.125O4 has two wave vectors of q=(1/2)[111] and q=the (1/2)[1-11]. Furthermore, the long-ranged CO structure in AlV_2O4 changes into the short-ranged one by substituting Cr ions into the V ones. The correlation length of CO in x=0.125 can be estimated to be about 5 nm. Our results suggest that the Cr doping destroyed the CO correlation effectively. It is revealed that by substituting Cr ions to V ones, the CO state is suppressed drastically and disappeared with x > 0.125. [1] K. Matsuno et al., J. Phys. Soc. Jpn 70, 1456 (2001)

  16. Survey of NASA V and V Processes/Methods

    NASA Technical Reports Server (NTRS)

    Pecheur, Charles; Nelson, Stacy

    2002-01-01

    The purpose of this report is to describe current NASA Verification and Validation (V&V) techniques and to explain how these techniques are applicable to 2nd Generation RLV Integrated Vehicle Health Management (IVHM) software. It also contains recommendations for special V&V requirements for IVHM. This report is divided into the following three sections: 1) Survey - Current NASA V&V Processes/Methods; 2) Applicability of NASA V&V to 2nd Generation RLV IVHM; and 3) Special 2nd Generation RLV IVHM V&V Requirements.

  17. Comparison of V-4 and V-5 Exercise/Oxygen Prebreathe Protocols to Support Extravehicular Activity in Microgravity

    NASA Technical Reports Server (NTRS)

    Pollock, N. W.; Natoli, M. J.; Vann, R. D.; Gernhardt, M. L.; Conkin, Johnny

    2007-01-01

    The Prebreathe Reduction Program (PRP) used exercise during oxygen prebreathe to reduce necessary prebreathe time prior to depressurizing to work in a 4.3 psi suit during extravehicular activity (EVA). Initial testing produced a two-hour protocol incorporating ergometry exercise and a 30 min cycle of depress/repress to 10.2 psi where subjects breathed 26.5% oxygen/balance nitrogen (Phase II - 10 min at 75% peak oxygen consumption [VO2 peak] followed by 40 min intermittent light exercise [ILE] [approx. 5.8 mL-per kilogram- per minute], then 50 min of rest). The Phase II protocol (0/45 DCS) was approved for operations and has been used on 40 EVAs, providing significant time savings compared to the standard 4 h resting oxygen prebreathe. The Phase V effort focused on performing all light in-suit exercise. Two oxygen prebreathe protocols were tested sequentially: V-4) 160 min prebreathe with 150 min of continuous ILE. The entire protocol was completed at 14.7 psi. All exercise involved upper body effort. Exercise continued until decompression. V-5) 160 min prebreathe with 140 min of ILE - first 40 min at 14.7 psi, then 30 min at 10.2 psi (breathing 26.5% oxygen) after a 20 min depress, simulating a suit donning period. Subjects were then repressed to 14.7 psi and performed another 50 min of lower body ILE, followed by 50 min rest before decompression. The V-4 protocol was rejected with 3 DCS/6 person-exposures. Initial V-5 testing has produced 0 DCS/11 person-exposures (ongoing trials). The difference in DCS rate was significant (Fisher Exact p=0.029). The observations of DCS were significantly lower in early V-5 trials than in V-4 trials. Additional studies are required to evaluate the relative contribution of the variables in exercise distribution, the 10.2 psi depress/repress component, pre-decompression rest, or possible variation in total oxygen consumption.

  18. Precision Measurements of the B(E1) Strengths in 11Be

    NASA Astrophysics Data System (ADS)

    Kwan, E.; Wu, C. Y.; Summers, N. C.; Hackman, G.; Drake, T. E.; Andreoiu, C.; Ashley, R.; Ball, G. C.; Bender, P. C.; Boston, A. J.; Boston, H. C.; Chester, A.; Close, A.; Cline, D.; Cross, D. S.; Dunlop, R.; Finley, A.; Garnsworthy, A.; Hayes, A. B.; Laffoley, A. T.; Nano, T.; Navrátil, P.; Pearson, C. J.; Pore, J.; Starosta, K.; Thompson, I. J.; Voss, P.; Williams, S. J.; Wang, Z. M.

    2014-09-01

    The electromagnetic transition strength between the two bound states were measured in the one-neutron halo nucleus 11Be from Coulomb excitation on 196Pt at projectile energies of 1.727 and 2.086 MeV/nucleon at TRIUMF. A B(E1) strength of 0.102(2) e2fm2, deduced from the forward-scattering data, is consistent with previous Coulomb excitation measurements at intermediate projectile energies with a model-dependent analysis.

  19. Absolute Rovibrational Intensities, Self-Broadening and Self-Shift Coefficients for the X(sup 1) Sigma(+) V=3 (left arrow) V=0 Band (C-12)(O-16)

    NASA Technical Reports Server (NTRS)

    Chackerian, Charles, Jr.; Freedman, R.; Giver, L. P.; Brown, L. R.

    2001-01-01

    The rotationless transition moment squared for the x(sup 1) sigma (sup +) v=3 (left arrow) v=0 band of CO is measured to be the absolute value of R (sub 3-0) squared = 1.7127(25)x 10(exp -7) Debye squared. This value is about 8.6 percent smaller than the value assumed for HITRAN 2000. The Herman-Wallis intensity factor of this band is F=1+0.01168(11)m+0.0001065(79)m squared. The determination of self-broadening coefficients is improved with the inclusion of line narrowing; self-shifts are also reported.

  20. Production Suitability of an Electroform Conductive Wax Process for the Manufacture of Fluidic Systems

    DTIC Science & Technology

    1975-11-01

    2l«^,«’) T>SL JI To «ATt JlOO «n «t* in. fTA * 3^ "PlbiA-e-*^ To wia •^ -IZ0"L6, (.21 >To «AUVK« ^-^STRlP^TiM e.ax>s «»I To RATft...8 C B E U^T^SJA ani« fMD ran © HMajrwelL "« TEftT COkTTRoL ’PAMB.V, ■•i’r^rT" I’» 1 Mj u 56- £ to i. — TOO*.« r7gi^iiiiniM.gi 4|ji»" mkd

  1. Puget Sound Tanker Size Optimization.

    DTIC Science & Technology

    1981-06-01

    6.0 ENTIRE FLEET 190 175 1,428,657 12,779.0 609.0 .- 01w OIW 77’ a LJ Iz-I, 61- 0 0 d - J c- 6-8 CLJ 6-8 E- L9 - a LA~ 1VIOI 40 IN331f3d 78 As mentioned...Transportation, U.S. Coast Guard. Report no. CG- D -21-77. 25. Wardley-Smith, J ., ed. 1979. The prevention of oil pollution. 26. Goldberg, N.N., Keith, V.F...Coast Guard. 80. Kahn, D .; Talbot, T.; and Woodward, J . Jan. 1974. Vessel safety model: vol. III Programmers’ manual. Final report. For the U.S

  2. [Simultaneous determination of 11 bisphenols in plastic bottled drinking water by ultra performance liquid chromatography-tandem mass spectrometry].

    PubMed

    Gou, Xinlei; Gao, Xia; Hu, Guanghui; Chi, Haitao; Le, Shengfeng; Wang, Wei; Liu, Weili

    2014-09-01

    A sensitive method was developed for the simultaneous determination of 11 bisphenols in plastic bottled drinking water by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The samples were freeze-dried under vacuum and then dissolved with methanol. The separation was performed on a UPLC BEH C18 column (100 mm x 2.1 mm, 1.7 μm) by using 0.1% (v/v) NH3 · H2O and methanol as mobile phases with gradient elution at a flow rate of 0.2 mL/min. The electrospray ionization (ESI) source in negative ion mode was used for the analysis of the 11 bisphenols in the multiple reaction monitoring (MRM) mode. The results verified that the standard curves for the 11 bisphenols were obtained with good correlation coefficients (R2) > 0.997 in their concentration ranges. The limits of detection (LOD, S/N = 3) for the 11 bisphenols were in the range of 0.01-1.00 μg/L. The mean recoveries for the 11 bisphenols at three spiked levels (low, middle, high) were 75.3%-102.1% with the relative standard deviations of 1.5%-8.9%. Seven plastic bottled drinking water samples were tested, and no bisphenol was found. The method is accurate, simple, rapid and feasible for the simultaneous determination of bisphenols in plastic bottled drinking water.

  3. Apollo 11 Astronauts Train For Lunar Rock Collection

    NASA Technical Reports Server (NTRS)

    1969-01-01

    In this photograph, Apollo 11 astronauts Edwin (Buzz) Aldrin (left) and Neil A. Armstrong prepare for the first Lunar landing as they practice gathering rock specimens during a geological field trip to the Quitman Mountains area near the Fort Quitman ruins in far west Texas. They used special lunar geological tools to pick up samples and place them in bags.Their practice paid off in July of the same year. Aboard the Marshall Space Fight center (MSFC) developed Saturn V launch vehicle, the Apollo 11 mission launched from the Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The 3-man crew aboard the flight consisted of Armstrong, commander; Aldrin, Lunar Module pilot; and a third astronaut Michael Collins, Command Module pilot. Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin, while Collins remained in lunar orbit. The crew collected 47 pounds of lunar surface material which was returned to Earth for analysis. The lunar surface exploration was concluded in 2½ hours.

  4. Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil.

    PubMed

    Hajlaoui, Hafedh; Mighri, Hedi; Aouni, Mahjoub; Gharsallah, Néji; Kadri, Adel

    2016-06-01

    This study investigated the chemical composition and evaluated the antioxidant, antimicrobial, cytotoxic and anti-acetylcholinesterase properties of Tunisian Origanum majorana essential oil. The findings showed that the oil exhibited high activity, particularly in terms of reducing power and β-Carotene bleaching, inducing higher IC50 values than BHT. The oil showed an important antimicrobial activity against 25 bacterial and fungal strains. In fact, the IZ, MIC and MBC values recorded for the bacterial strains were in the range of 8 ± 0-18.33 ± 0.57 mm, 0.097-3.125 and 0.39-6.25 mg/mL, respectively. The IZ, MIC and MFC values of the fungal strains varied between 11±0-28 ± 0 mm, 0.058-0.468 mg/mL and 0.234-1.875 mg/mL, respectively. A low cytotoxic effect was observed against cancer (Hep-2 and HT29) and continuous cell lineage (Vero), with CC50 values ranging from 13.73 to 85.63 mg/mL. The oil was also evaluated for anti-acetylcholinesterase effects, which showed that it exhibited significant activity with IC50 values reaching 150.33 ± 2.02 μg/mL. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Antimicrobial Activity of a Neem Cake Extract in a Broth Model Meat System

    PubMed Central

    Del Serrone, Paola; Nicoletti, Marcello

    2013-01-01

    This work reports on the antimicrobial activity of an ethyl acetate extract of neem (Azadirachta indica) cake (NCE) against bacteria affecting the quality of retail fresh meat in a broth model meat system. NCE (100 µg) was also tested by the agar disc diffusion method. It inhibited the growth of all tested microorganisms. The NCE growth inhibition zone (IZ) ranged 11.33–22.67 mm while the ciprofloxacin (10 µg) IZ ranged from 23.41–32.67 mm. There was no significant difference (p ≤ 0.05) between the antimicrobial activity of NCE and ciprofloxacin vs. C. jejuni and Leuconostoc spp. The NCE antibacterial activity was moreover determined at lower concentrations (1:10–1:100,000) in micro-assays. The percent growth reduction ranged from 61 ± 2.08–92 ± 3.21. The higher bacterial growth reduction was obtained at 10 µg concentration of NCE. Species-specific PCR and multiplex PCR with the DNA dye propidium monoazide were used to directly detect viable bacterial cells from experimentally contaminated meat samples. The numbers of bacterial cells never significantly (p ≤ 0.05) exceeded the inocula concentration used to experimentally contaminate the NCE treated meat. This report represents a screening methodology to evaluate the antimicrobial capability of a herbal extract to preserve meat. PMID:23917814

  6. Orally active, nonpeptide vasopressin V1 antagonists. A novel series of 1-(1-substituted 4-piperidyl)-3,4-dihdyro-2(1H)-quinolinone.

    PubMed

    Ogawa, H; Yamamura, Y; Miyamoto, H; Kondo, K; Yamashita, H; Nakaya, K; Chihara, T; Mori, T; Tominaga, M; Yabuuchi, Y

    1993-07-09

    A series of compounds has been synthesized and demonstrated to be antagonists of V1 receptors both in vitro and in vivo. These compounds are structurally related to the 1-(4-piperidyl)-2(1H)-quinolinones, including OPC-21268, an orally bioavailable AVP V1 antagonist with high V1 specificity. It has been found that the introduction of an acetamide group on the terminal alkoxy chain of 41-44 leads to an increase in oral activity. Certain of these compounds may have efficacy in the study of AVP V1 receptors.

  7. Modification of solubility and heat-induced gelation of amaranth 11S globulin by protein engineering.

    PubMed

    Carrazco-Peña, Laura; Osuna-Castro, Juan A; De León-Rodríguez, Antonio; Maruyama, Nobuyuki; Toro-Vazquez, Jorge F; Morales-Rueda, Juan A; Barba de la Rosa, Ana P

    2013-04-10

    The primary structure of amaranth 11S globulin (Ah11S) was engineered with the aim to improve its functional properties. Four continuous methionines were inserted in variable region V, obtaining the Ah11Sr+4M construction. Changes on protein structure and surface characteristics were analyzed in silico. Solubility and heat-induced gelation of recombinant amaranth 11S proglobulin (Ah11Sr and Ah11Sr+4M) were compared with the native protein (Ah11Sn) purified from amaranth seed flour. The Ah11Sr+4 M showed the highest surface hydrophobicity, but as consequence the solubility was reduced. At low ionic strength (μ = 0.2) and acidic pH (<4.1), the recombinant proteins Ah11Sr and Ah11Sr+4 M had the highest and lowest solubility values, respectively. All globulins samples formed gels at 90 °C and low ionic strength, but Ah11Sn produced the weakest and Ah11Sr the strongest gels. Differential scanning calorimetry analysis under gel forming conditions revealed only exothermic transitions for all amaranth 11S globulins analyzed. In conclusion, the 3D structure analysis has revealed interesting molecular features that could explain the thermal resistance and gel forming ability of amaranth 11S globulins. The incorporation of four continuous methionines in amaranth increased the hydrophobicity, and self-supporting gels formed had intermediate hardness between Ah11Sn and Ah11Sr. These functional properties could be used in the food industry for the development of new products based on amaranth proteins.

  8. The metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer

    PubMed Central

    QU, YING; ZHOU, CHENFEI; ZHANG, JIANIAN; CAI, QU; LI, JIANFANG; DU, TAO; ZHU, ZHENGGANG; CUI, XIAOJIANG; LIU, BINGYA

    2014-01-01

    SOX11 is involved in gastrulation and in malignant diseases. The aim of this study was to investigate the role of SOX11 in gastric cancer and its expression pattern and clinical significance. SOX11 overexpression cell model was used to examine in vitro and in vivo the role of SOX11 in cell growth and metastasis. Cell cycle analysis and Annexin V/PI double staining were used to investigate the effect of SOX11 on cell cycle progression and apoptosis. The expression of SOX11 in human gastric cancer was examined by immunohistochemistry. The correlation of SOX11 expression with clinicopathological characteristics and survival of patients was analyzed by Pearson’s χ2 and Kaplan-Meier analyses, respectively. Cox’s proportional hazard model was employed in multivariate analysis. SOX11 overexpression did not inhibit cell growth but strongly suppressed cell migration/invasion in vitro and in vivo. We found a significant correlation between high SOX11 protein levels and Lauren’s classification (intestinal type), differentiation status (high and medium), and early TNM stage. SOX11 is an independent prognostic factor for improved survival in gastric cancer patients. SOX11 was a potential tumor-suppressor and an independent positive prognostic factor in gastric cancer patients with less advanced clinicopathological features. PMID:24604109

  9. Mutational analysis of the PTPN11 gene in Egyptian patients with Noonan syndrome.

    PubMed

    Essawi, Mona L; Ismail, Manal F; Afifi, Hanan H; Kobesiy, Maha M; El Kotoury, Ahmed; Barakat, Maged M

    2013-11-01

    Noonan syndrome (NS) is inherited as an autosomal dominant disorder with dysmorphic facies, short stature, and cardiac defects, which can be caused by missense mutations in the protein tyrosine phosphatase nonreceptor type 11 (PTPN11) gene, which encodes src homology region 2 domain containing tyrosine phosphatase-2 (SHP-2), a protein tyrosine phosphatase that acts in signal transduction downstream to growth factors and cytokines. The current study aimed to study the molecular characterization of the PTPN11 gene among Egyptian patients with Noonan syndrome. Eleven exons of the PTPN11 gene were amplified and screened by single stranded conformational polymorphism (SSCP). DNA samples showing band shift in SSCP were subjected to sequencing. Mutational analysis of the PTPN11 gene revealed T→C transition at position 854 in exon 8, predicting Phe285Ser substitution within PTP domain of SHP-2 protein, in one NS patient and -21C→T polymorphism in intron 7 in four other cases. Knowing that NS is phenotypically heterogeneous, molecular characterization of the PTPN11 gene should serve to establish NS diagnosis in patients with atypical features, although lack of a mutation does not exclude the possibility of NS. Copyright © 2012. Published by Elsevier B.V.

  10. Location of multiparticle-multihole strength in 16N via the 3-particle transfer reaction 13C(α, p) 16N at 118 MeV

    NASA Astrophysics Data System (ADS)

    Andrews, P. R.; Shute, G. G.; Spicer, B. M.; Collins, S. F.; Officer, V. C.; Wastell, J. M.; Nann, H.; Devins, D. W.; LI, Qingli; Jones, W. P.; Olmer, C.; Bacher, A. D.; Emery, G. T.

    1986-11-01

    Differential cross sections were measured for the 13C(α, p) 16N reaction at Eα = 118 MeV for an excitation energy range up to 14.5 MeV. Zero-range distorted wave Born approximation (DWBA) calculations were performed using microscopic form factors. Spin-parity assignments are suggested for states at 11.21 MeV (6 -) and 11.81 MeV (7 -) on the basis of Bansal-French-Zamick weak coupling calculations and DWBA calculations. Arguments from 16O(e, e'), 16O(p, p') and the present experiment are given relating to the location of Jπ = 4 -, T = 1 strength in 16N.

  11. KELT-10b and KELT-11b: Two Sub-Jupiter Mass Planets well-Suited for Atmospheric Characterization in the Southern Hemisphere

    NASA Astrophysics Data System (ADS)

    Rodriguez, Joseph E.

    2015-12-01

    The Kilodegree Extremely Little Telescope (KELT) project is a photometric survey in both the northern and southern hemispheres for transiting planets around bright stars (8 < V < 11), and has discovered 15 planets to date. Of these, several possess unique characteristics that make them especially well suited for study of planet atmospheres. Here, I present the first two discoveries from the KELT-South survey. KELT-10b is an inflated transiting sub-Jupiter mass planet (0.68 MJ) around a V=10.7 early G-star. It has the 3rd deepest transit (1.4%) in the southern hemisphere for a star V < 12.5, making it a great target for transmission spectroscopy. KELT-11b is a highly inflated transiting Saturn mass planet (0.22 MJ) orbiting one of the brightest planet-hosting stars in the southern hemisphere. Interestingly, KELT-11b's host star is a clear sub-giant star (log(g) ~ 3.7). I will discuss their impact for atmospheric characterization. For example, the highly inflated nature of the KELT-11b planet provides the ability to study a sub-Jupiter atmosphere at very low planetary gravity, while the sub-giant nature of its host star allows us to study the effects of post main sequence evolution of a host star on a hot Jupiter.

  12. Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels.

    PubMed

    Mindthoff, Sabrina; Grunau, Silke; Steinfort, Laura L; Girzalsky, Wolfgang; Hiltunen, J Kalervo; Erdmann, Ralf; Antonenkov, Vasily D

    2016-02-01

    More than 30 proteins (Pex proteins) are known to participate in the biogenesis of peroxisomes-ubiquitous oxidative organelles involved in lipid and ROS metabolism. The Pex11 family of homologous proteins is responsible for division and proliferation of peroxisomes. We show that yeast Pex11 is a pore-forming protein sharing sequence similarity with TRPM cation-selective channels. The Pex11 channel with a conductance of Λ=4.1 nS in 1.0M KCl is moderately cation-selective (PK(+)/PCl(-)=1.85) and resistant to voltage-dependent closing. The estimated size of the channel's pore (r~0.6 nm) supports the notion that Pex11 conducts solutes with molecular mass below 300-400 Da. We localized the channel's selectivity determining sequence. Overexpression of Pex11 resulted in acceleration of fatty acids β-oxidation in intact cells but not in the corresponding lysates. The β-oxidation was affected in cells by expression of the Pex11 protein carrying point mutations in the selectivity determining sequence. These data suggest that the Pex11-dependent transmembrane traffic of metabolites may be a rate-limiting step in the β-oxidation of fatty acids. This conclusion was corroborated by analysis of the rate of β-oxidation in yeast strains expressing Pex11 with mutations mimicking constitutively phosphorylated (S165D, S167D) or unphosphorylated (S165A, S167A) protein. The results suggest that phosphorylation of Pex11 is a mechanism that can control the peroxisomal β-oxidation rate. Our results disclose an unexpected function of Pex11 as a non-selective channel responsible for transfer of metabolites across peroxisomal membrane. The data indicate that peroxins may be involved in peroxisomal metabolic processes in addition to their role in peroxisome biogenesis. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. [Determination of 11 anabolic hormones in fish tissue by multi-function impurity adsorption solid-phase extraction-ultrafast liquid chromatography-tandem mass spectrometry].

    PubMed

    Yao, Shanshan; Zhao, Yonggang; Li, Xiaoping; Chen, Xiaohong; Jin, Micong

    2012-06-01

    A method was developed for the determination of 11 anabolic hormones (boldenone, androstenedione, nandrolone, methandrostenolone, methyltestosterone, testosterone, testosterone acetate, trenbolone, testosterone propionate, stanozolol, fluoxymesterone) in fish by multi-function impurity adsorption solid-phase extraction-ultrafast liquid chromatography-tandem mass spectrometry. After the sample was extracted by methanol, the extract was cleaned-up quickly by C18 adsorbent, neutral alumina adsorbent and amino-functionalized nano-adsorbent. The separation was performed on a Shim-Pack XR-ODS II column (100 mm x 2.0 mm, 2.2 microm) using the mobile phases of 0.1% (v/v) formic acid in acetonitrile and 0.1% (v/v) formic acid solution in a gradient elution mode. The identification and quantification were achieved by using electrospray ionization in positive ion mode (ESI+) in multiple reaction monitoring (MRM) mode. The matrix-matched external standard calibration curves were used for quantitative determination. The results showed that the calibration curves were in good linearity for the eleven analytes with the correlation coefficients (r) more than 0.999. The limits of detection (LODs, S/N > 3) for the 11 anabolic hormones were from 0.03 microg/kg to 0.4 microg/kg and the limits of quantification (LOQs, S/N > 10) were from 0.1 microg/kg to 1.5 microg/kg. The average recoveries ranged from 80.9% to 98.1% with the relative standard deviations between 5.2% and 11.5%. The method is simple, rapid, sensitive, accurate and suitable for the quantitative determination and confirmation of the 11 anabolic hormones in fish.

  14. Evaluation of candidate geomagnetic field models for IGRF-11

    NASA Astrophysics Data System (ADS)

    Finlay, C. C.; Maus, S.; Beggan, C. D.; Hamoudi, M.; Lowes, F. J.; Olsen, N.; Thébault, E.

    2010-10-01

    The eleventh generation of the International Geomagnetic Reference Field (IGRF) was agreed in December 2009 by a task force appointed by the International Association of Geomagnetism and Aeronomy (IAGA) Division V Working Group V-MOD. New spherical harmonic main field models for epochs 2005.0 (DGRF-2005) and 2010.0 (IGRF-2010), and predictive linear secular variation for the interval 2010.0-2015.0 (SV-2010-2015) were derived from weighted averages of candidate models submitted by teams led by DTU Space, Denmark (team A); NOAA/NGDC, U.S.A. (team B); BGS, U.K. (team C); IZMIRAN, Russia (team D); EOST, France (team E); IPGP, France (team F); GFZ, Germany (team G) and NASA-GSFC, U.S.A. (team H). Here, we report the evaluations of candidate models carried out by the IGRF-11 task force during October/November 2009 and describe the weightings used to derive the new IGRF-11 model. The evaluations include calculations of root mean square vector field differences between the candidates, comparisons of the power spectra, and degree correlations between the candidates and a mean model. Coefficient by coefficient analysis including determination of weighting factors used in a robust estimation of mean coefficients is also reported. Maps of differences in the vertical field intensity at Earth's surface between the candidates and weighted mean models are presented. Candidates with anomalous aspects are identified and efforts made to pinpoint both troublesome coefficients and geographical regions where large variations between candidates originate. A retrospective analysis of IGRF-10 main field candidates for epoch 2005.0 and predictive secular variation candidates for 2005.0-2010.0 using the new IGRF-11 models as a reference is also reported. The high quality and consistency of main field models derived using vector satellite data is demonstrated; based on internal consistency DGRF-2005 has a formal root mean square vector field error over Earth's surface of 1.0 nT. Difficulties

  15. 11 CFR 104.11 - Continuous reporting of debts and obligations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... 104.11 Section 104.11 Federal Elections FEDERAL ELECTION COMMISSION GENERAL REPORTS BY POLITICAL... reported until extinguished. See 11 CFR 104.3(d). These debts and obligations shall be reported on separate... reported amount or value, the reporting committee shall include a statement as to the circumstances and...

  16. Progress in the Development of Metamorphic Multi-Junction III-V Space-Solar Cells at Essential Research Incorporated

    NASA Technical Reports Server (NTRS)

    Sinharoy, Samar; Patton, Martin O.; Valko, Thomas M., Sr.; Weizer, Victor G.

    2002-01-01

    Theoretical calculations have shown that highest efficiency III-V multi-junction solar cells require alloy structures that cannot be grown on a lattice-matched substrate. Ever since the first demonstration of high efficiency metamorphic single junction 1.1 eV and 1.2 eV InGaAs solar cells by Essential Research Incorporated (ERI), interest has grown in the development of multi-junction cells of this type using graded buffer layer technology. ERI is currently developing a dual-junction 1.6 eV InGaP/1.1 eV InGaAs tandem cell (projected practical air-mass zero (AM0), one-sun efficiency of 28%, and 100-sun efficiency of 37.5%) under a Ballistic Missile Defense Command (BMDO) SBIR Phase II program. A second ongoing research effort at ERI involves the development of a 2.1 eV AlGaInP/1.6 eV InGaAsP/1.2 eV InGaAs triple-junction concentrator tandem cell (projected practical AM0 efficiency of 36.5% under 100 suns) under a SBIR Phase II program funded by the Air Force. We are in the process of optimizing the dual-junction cell performance. In case of the triple-junction cell, we have developed the bottom and the middle cell, and are in the process of developing the layer structures needed for the top cell. A progress report is presented in this paper.

  17. Differences in photoreceptor recovery among patients and between different parts of the posterior pole in Vogt–Koyanagi–Harada disease

    PubMed Central

    Zhou, M; Gu, R P; Sun, Z; Jiang, C H; Chang, Q; Xu, G Z

    2018-01-01

    Purpose To investigate the recovery of photoreceptors following the treatment in Vogt–Koyanagi–Harada (VKH) disease. Patients and methods This was a retrospective study. We enrolled 28 patients with VKH (56 eyes). The clinical and optical coherence tomography (OCT) findings were recorded for 12 months after treatment. The patterns of photoreceptor recovery on OCT were defined: pattern F group=Foveal photoreceptor recovery visible first; pattern E group=Extrafoveal photoreceptor recovery visible first; and pattern S group=Simultaneous foveal and extrafoveal photoreceptor recovery. Results Photoreceptor recovery varied in different parts of the fundus among patients. Among the 56 eyes, the ellipsoid zone (EZ) recovery of 10 eyes and the interdigitation zone (IZ) recovery of 17 eyes belonged to pattern F group. In most eyes (46 eyes for EZ and 26 eyes for IZ), the recovery of these structures were pattern S. Only in 10 eyes, the recovery of IZ was pattern E. The different patterns of recovery correlated with how promptly the patients had been treated and with the anatomical and visual outcomes at 12 months. Patients in pattern F group were characterized by delayed treatment, delayed recovery of EZ or IZ, and a less favourable prognosis at 12 months relative to other patients, while those in pattern E group had the most prompt treatment and recovery as well as a more favourable outcome at 12 months. Conclusions In VKH patients with delayed treatment, foveal photoreceptors tended to recover more rapidly than photoreceptors in other regions. PMID:29148525

  18. Mapping of Hot/Cold Springs in a Large Lake Using Thermal Remote Sensing and In-situ Measurement

    NASA Astrophysics Data System (ADS)

    Gurcan, T.; Kurtulus, B.; Avşar

    2016-12-01

    In this study, in-situ measurement and thermal infrared imagery was used to map hot and cold springs of Köyceǧiz Lake in Turkey, which is one of the biggest open coastal lakes in the world. In-situ surface, depth water temperature, climatic data and bathymetry measurement were collected using data loggers. Landsat 8 TIRS Band 10 (Thermal Infrared Sensors) images were compared with in-situ measurements. Electrical conductivity, pH and salinity measurement were also collected at the bottom of the lake to better understand the groundwater discharge evidence in the lake. In-situ measurement were interpolated using Empirical Bayesian Kriging (EBK). In-Situ measurement and Landsat 8 Images were compared pixel by pixel and appropriate regression equation were calculated according to best coefficient of correlation (R2). The results show that in-situ measurement of temperature at surface of the Köyceǧiz Lake has a good correlation for several cases (R2 ≥ 0.7) with Landsat 8 TIR images (Figure1). The mapping results of in-situ measurements also reveal that at the north east part of the Köyceǧiz Lake there exist several evidence of cold spring at the bottom of the Lake. Hot spring evidence were located at the South-West part of the Köyceǧiz Lake near the Sultaniye region. In this regard, we would like to thank TUBITAK project (112Y137) for their financial support.

  19. Hydrogen peroxide biosensor based on microperoxidase-11 immobilized in a silica cavity array electrode.

    PubMed

    Tian, Shu; Zhou, Qun; Gu, Zhuomin; Gu, Xuefang; Zhao, Lili; Li, Yan; Zheng, Junwei

    2013-03-30

    Hydrogen peroxide biosensor based on the silica cavity array modified indium-doped tin oxide (ITO) electrode was constructed. An array of silica microcavities was fabricated by electrodeposition using the assembled polystyrene particles as template. Due to the resistance gradient of the silica cavity structure, the silica cavity exhibits a confinement effect on the electrochemical reactions, making the electrode function as an array of "soft" microelectrodes. The covalently immobilized microperoxidase-11(MP-11) inside these SiO2 cavities can keep its physiological activities, the electron transfer between the MP-11 and electrode was investigated through electrochemical method. The cyclic voltammetric curve shows a quasi-reversible electrochemical redox behavior with a pair of well-defined redox peaks, the cathodic and anodic peaks are located at -0.26 and -0.15V. Furthermore, the modified electrode exhibits high electrocatalytic activity toward the reduction of hydrogen peroxide and also shows good analytical performance for the amperometric detection of H2O2 with a linear range from 2×10(-6) to 6×10(-4)M. The good reproducibility and long-term stability of this novel electrode not only offer an opportunity for the detection of H2O2 in low concentration, but also provide a platform to construct various biosensors based on many other enzymes. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. High-resolution oscillator strength measurements for the A(v') - X(0) bands of carbon monoxide with 11 less than or equal to v' less than or equal to 14

    NASA Technical Reports Server (NTRS)

    Smith, Peter L.; Stark, G.; Yoshino, K.; Ito, K.

    1994-01-01

    Band oscillator strengths (f-values) for four bands of the Fourth Positive system (A (1)Pi - Chi(sup 1) Sigma(+)) of CO have been determined from high-resolution (lambda/Delta lambda approximately equal to 150,000) absorption spectra. The bands, (14, 0) through (11, 0), are at wavelengths between 121 and 127 nm. Our f-values for the (11, 0) and (12, 0) bands support those of Chan, Cooper, & Brion (1993), which have been shown to be consistent with observations of CO in the clouds in the line of sight to zeta Oph. Our f-values for the (13, 0) and (14, 0) bands are the first directly measured values for these bands.