Electron cloud simulations for the main ring of J-PARC

NASA Astrophysics Data System (ADS)

Yee-Rendon, Bruce; Muto, Ryotaro; Ohmi, Kazuhito; Satou, Kenichirou; Tomizawa, Masahito; Toyama, Takeshi

2017-07-01

The simulation of beam instabilities is a helpful tool to evaluate potential threats against the machine protection of the high intensity beams. At Main Ring (MR) of J-PARC, signals related to the electron cloud have been observed during the slow beam extraction mode. Hence, several studies were conducted to investigate the mechanism that produces it, the results confirmed a strong dependence on the beam intensity and the bunch structure in the formation of the electron cloud, however, the precise explanation of its trigger conditions remains incomplete. To shed light on the problem, electron cloud simulations were done using an updated version of the computational model developed from previous works at KEK. The code employed the signals of the measurements to reproduce the events seen during the surveys.

The TREK/E36 experiment at J-PARC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kohl, M.; Collaboration: TREK Collaboration

2013-11-07

Experiment E36 is planned to run at the J-PARC K1.1BR kaon beamline in 2014-15 using a stopped kaon beam along with the TREK target and detector setup. The decay products of stopped positive kaons will be observed with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the K{sub e2}/K{sub μ2} ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to searchmore » for a heavy sterile neutrino in two-body kaon decay, along with additional searches for exotic decay modes including the possibility to produce a dark photon and to observe its decay into an e{sup +}e{sup −} pair. An overview of the planned measurements with E36 will be presented.« less

Maintenance and operation procedure, and feedback controls of the J-PARC RF-driven H{sup −} ion source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ueno, A., E-mail: akira.ueno@j-parc.jp; Ohkoshi, K.; Ikegami, K.

2015-04-08

In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The maintenance and operation procedure to minimize the plasma chamber (PCH) replacement time on the beam line, which is very important to maximize the J-PARC beam time especially for an antenna failure,more » is presented in this paper. The PCH preserved by filling argon (Ar) gas inside after pre-conditioning including pre-cesiation to produce the required beam at a test-stand successfully produced the required beam on the beam line with slight addition of cesium (Cs). The methods of the feedback controls of a 2MHz-RF-matching, an H{sup −} ion beam intensity and the addition of Cs are also presented. The RF-matching feedback by using two vacuum variable capacitors (VVCs) and RF-frequency shift produced the almost perfect matching with negligibly small reflected RF-power. The H{sup −} ion beam intensity was controlled within errors of ±0.1mA by the RF-power feedback. The amount of Cs was also controlled by remotely opening a Cs-valve to keep the RF-power lower than a settled value.« less

Birth of an intense pulsed muon source, J-PARC MUSE

NASA Astrophysics Data System (ADS)

Miyake, Yasuhiro; Shimomura, Koichiro; Kawamura, Naritoshi; Strasser, Patrick; Makimura, Shunsuke; Koda, Akihiro; Fujimori, Hiroshi; Nakahara, Kazutaka; Kadono, Ryosuke; Kato, Mineo; Takeshita, Soshi; Nishiyama, Kusuo; Higemoto, Wataru; Ishida, Katsuhiko; Matsuzaki, Teiichiro; Matsuda, Yasuyuki; Nagamine, Kanetada

2009-04-01

The muon science facility (MUSE), along with neutron, hadron, and neutrino facilities, is one of the experimental areas of the J-PARC (Japan Proton Accelerator Research Complex) project, which was approved for construction between 2001 and 2008. The MUSE facility is located in the Materials and Life Science Facility (MLF), which is a building integrated to include both neutron and muon science programs. Construction of the MLF building was started at the beginning of 2004, and was recently completed at the end of the 2006 fiscal year. We have been working on the installation of the beamline components, expecting the first muon beam in the autumn of 2008. For Phase 1, we are planning to install one superconducting decay/surface channel with a modest-acceptance (about 40 mSr) pion injector, with an estimated surface muon (μ+) rate of 3×107/s and a beam size of 25 mm diameter, and a corresponding decay muon (μ+/μ-) rate of 106/s for 60 MeV/ c (up to 107/s for 120 MeV/ c) with a beam size of 50 mm diameter. These intensities correspond to more than 10-times what is available at the RIKEN/RAL muon facility, which currently possess the most intense pulsed muon beams in the world. In addition to Phase 1, we are planning to install, a surface muon channel with a modest-acceptance (about 50 mSr), mainly for experiments related to material sciences, and a super-omega muon channel with a large acceptance of 400 mSr. In the case of the super-omega muon channel, the goal is to extract 4×108 surface muons/s for the generation of ultra-slow muons and 1×107 negative cloud muons/s with a momentum of 30-60 MeV/ c. One of the important goals for this beamline is to generate intense ultra-slow muons at MUSE, utilizing an intense pulsed VUV laser system. 104-106 ultra-slow muons/s are expected, which will allow for an extension of μSR into the area of thin film and surface science. At this symposium, the current status of J-PARC MUSE will be reported.

Pressure and temperature fluctuation simulation of J-PARC cryogenic hydrogen system

NASA Astrophysics Data System (ADS)

Tatsumoto, H.; Ohtsu, K.; Aso, T.; Kawakami, Y.

2015-12-01

The J-PARC cryogenic hydrogen system provides supercritical cryogenic hydrogen to the moderators at a pressure of 1.5 MPa and temperature of 18 K and removes 3.8 kW of nuclear heat from the 1 MW proton beam operation. We prepared a heater for thermal compensation and an accumulator, with a bellows structure for volume control, to mitigate the pressure fluctuation caused by switching the proton beam on and off. In this study, a 1-D simulation code named DiSC-SH2 was developed to understand the propagation of pressure and temperature propagations through the hydrogen loop due to on and off switching of the proton beam. We confirmed that the simulated dynamic behaviors in the hydrogen loop for 300-kW and 500-kW proton beam operations agree well with the experimental data under the same conditions.

Emittance measurements for optimum operation of the J-PARC RF-driven H{sup −} ion source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ueno, A., E-mail: akira.ueno@j-parc.jp; Ohkoshi, K.; Ikegami, K.

2015-04-08

In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The transverse emittances of the source were measured with various conditions to find out the optimum operation conditions minimizing the horizontal and vertical rms normalized emittances. The transverse emittances were most effectivelymore » reduced by operating the source with the plasma electrode temperature lower than 70°C. The optimum value of the cesium (Cs) density around the beam hole of the plasma electrode seems to be proportional to the plasma electrode temperature. The fine control of the Cs density is indispensable, since the emittances seem to increase proportionally to the excessiveness of the Cs density. Furthermore, the source should be operated with the Cs density beyond a threshold value, since the plasma meniscus shape and the ellipse parameters of the transverse emittances seem to be changed step-function-likely on the threshold Cs value.« less

The EPICS-based remote control system for muon beam line devices at J-PARC MUSE

NASA Astrophysics Data System (ADS)

Ito, T. U.; Nakahara, K.; Kawase, M.; Fujimori, H.; Kobayashi, Y.; Higemoto, W.; Miyake, Y.

2010-04-01

The remote control system for muon beam line devices of J-PARC MUSE has been developed with the Experimental Physics and Industrial Control System (EPICS). The EPICS input/output controller was installed in standard Linux PCs for slow control of the devices. Power supplies for 21 magnetic elements and four slit controllers for the decay-surface muon beam line in the Materials and Life Science Experimental Facility are now accessible via Ethernet from a graphical user interface which has been composed using the Motif Editor and Display Manger.

Ultra slow muon microscopy by laser resonant ionization at J-PARC, MUSE

NASA Astrophysics Data System (ADS)

Miyake, Y.; Ikedo, Y.; Shimomura, K.; Strasser, P.; Kawamura, N.; Nishiyama, K.; Koda, A.; Fujimori, H.; Makimura, S.; Nakamura, J.; Nagatomo, T.; Kadono, R.; Torikai, E.; Iwasaki, M.; Wada, S.; Saito, N.; Okamura, K.; Yokoyama, K.; Ito, T.; Higemoto, W.

2013-04-01

As one of the principal muon beam line at the J-PARC muon facility (MUSE), we are now constructing a Muon beam line (U-Line), which consists of a large acceptance solenoid made of mineral insulation cables (MIC), a superconducting curved transport solenoid and superconducting axial focusing magnets. There, we can extract 2 × 108/s surface muons towards a hot tungsten target. At the U-Line, we are now establishing a new type of muon microscopy; a new technique with use of the intense ultra-slow muon source generated by resonant ionization of thermal Muonium (designated as Mu; consisting of a μ + and an e - ) atoms generated from the surface of the tungsten target. In this contribution, the latest status of the Ultra Slow Muon Microscopy project, fully funded, is reported.

Status of the New Surface Muon Beamline at J-PARC MUSE

NASA Astrophysics Data System (ADS)

Strasser, P.; Koda, A.; Kojima, K. M.; Ito, T. U.; Fujimori, H.; Irie, Y.; Aoki, M.; Nakatsugawa, Y.; Higemoto, W.; Hiraishi, M.; Li, H.; Okabe, H.; Takeshita, S.; Shimomura, K.; Kawamura, N.; Kadono, R.; Miyake, Y.

A new surface muon beamline (S-line) dedicated to condensed matter physics experiments is being constructed at the Muon Science Facility (MUSE) located in the Materials and Life Science Facility (MLF) building at J-PARC. This beamline designed to provide high-intensity surface muons with a momentum of 28 MeV/c will comprise four beam legs and four experimental areas that will share the double-pulsed muon beam. The key feature is a new kicker system comprising two electric kickers to deliver the muon beam to the four experimental areas ensuring an optimum and seamless sharing of the double-pulsed muon beam. At present, only one experimental area (S1) has been completed and is now open to the user program since February 2017. An overview of the different aspects of this new surface muon beamline and the present status of the beam commissioning are presented.

Capture Cross-section Measurement of 241Am(n,γ) at J-PARC/MLF/ANNRI

NASA Astrophysics Data System (ADS)

Harada, H.; Ohta, M.; Kimura, A.; Furutaka, K.; Hirose, K.; Hara, K. Y.; Kin, T.; Kitatani, F.; Koizumi, M.; Nakamura, S.; Oshima, M.; Toh, Y.; Igashira, M.; Katabuchi, T.; Mizumoto, M.; Kino, K.; Kiyanagi, Y.; Fujii, T.; Fukutani, S.; Hori, J.; Takamiya, K.

2014-05-01

The 241Am(n, γ) 242Am cross sections have been measured for neutron energies between 0.01 and 10 eV using the Accurate Neutron-Nucleus Reaction measurement Instrument (ANNRI) installed at the Materials and Life-science experimental Facility (MLF) in J-PARC. ANNRI combines the strongest neutron-pulsed beam and a high energy resolution γ-ray spectrometer, making possible accurate measurements of neutron capture cross sections for highly radioactive samples. From the measured cross section, the Westcott neutron capture factor and strength of the first three resonances in 241Am are deduced. These results with precision less than 0.5 % are compared with those derived from JENDL-4.0.

Polarization analysis for magnetic field imaging at RADEN in J-PARC/MLF

NASA Astrophysics Data System (ADS)

Shinohara, Takenao; Hiroi, Kosuke; Su, Yuhua; Kai, Tetsuya; Nakatani, Takeshi; Oikawa, Kenichi; Segawa, Mariko; Hayashida, Hirotoshi; Parker, Joseph D.; Matsumoto, Yoshihiro; Zhang, Shuoyuan; Kiyanagi, Yoshiaki

2017-06-01

Polarized neutron imaging is an attractive method for visualizing magnetic fields in a bulk object or in free space. In this technique polarization of neutrons transmitted through a sample is analyzed position by position to produce an image of the polarization distribution. In particular, the combination of three-dimensional spin analysis and the use of a pulsed neutron beam is very effective for the quantitative evaluation of both field strength and direction by means of the analysis of the wavelength dependent polarization vector. Recently a new imaging instrument “RADEN” has been constructed at the beam line of BL22 of the Materials and Life Science Experimental Facility (MLF) at J-PARC, which is dedicated to energy-resolved neutron imaging experiments. We have designed a polarization analysis apparatus for magnetic field imaging at the RADEN instrument and have evaluated its performance.

DEVELOPMENT OF SUPERCONDUCTING COMBINED FUNCTION MAGNETS FOR THE PROTON TRANSPORT LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NAKAMOTO, T.; AJIMA, Y.; FUJII, Y.

2005-05-16

Superconducting combined function magnets will be utilized for the 50 GeV, 750 kW proton beam line for the J-PARC neutrino experiment. The magnet is designed to provide a dipole field of 2.6 T combined with a quadrupole field of 19 T/m in a coil aperture of 173.4 mm at a nominal current of 7345 A. Two full-scale prototype magnets to verify the magnet performance were successfully developed. The first prototype experienced no training quench during the excitation test and good field quality was confirmed.

Probing Strong Interaction with Kaonic Atoms — from DAΦNE to J-PARC

NASA Astrophysics Data System (ADS)

Zmeskal, J.; Sato, M.; Bazzi, M.; Beer, G.; Berucci, C.; Bosnar, D.; Bragadireanu, M.; Buehler, P.; Cargnelli, M.; Clozza, A.; Curceanu, C.; D'uffizi, A.; Fabbietti, L.; Fiorini, C.; Ghio, F.; Golser, R.; Guaraldo, C.; Hashimoto, T.; Hayano, R. S.; Iliescu, M.; Itahashi, K.; Iwasaki, M.; Levi Sandri, P.; Marton, J.; Moskal, P.; Ohnishi, H.; Okada, S.; Outa, H.; Pietreanu, D.; Piscicchia, K.; Poli Lener, M.; Romero Vidal, A.; Sakuma, F.; Sbardella, E.; Scordo, A.; Shi, H.; Sirghi, D.; Sirghi, F.; Suzuki, K.; Tucakovic, I.; Vazquez Doce, O.; Widmann, E.

The study of the antikaon nucleon system at very low energies plays a key role to study strong interaction with strangeness, touching one of the fundamental problems in hadron physic today — the still unsolved question of how hadron masses are generated. Exotic atoms offer a unique possibility to determine s-wave kaon-nucleon scattering lengths at vanishing energy. At the DAΦNE electron positron collider of Laboratori Nazionali di Frascati in the SIDDHARTA experiment kaonic atoms were formed with Z = 1 (K-p) and Z = 2 (K-He), which were measured with up to now unrivalled precision. This experiment is taking advantage of the low-energy charged kaons from ϕ-mesons decaying nearly at rest. Finally, using the experience gained with SIDDHARTA, a proposal to measure kaonic deuterium for the first time was submitted to J-PARC with the goal to determine the isospin dependent scattering lengths, which is only possible by combining the K-p and the upcoming K-d results.

Vacuum tube operation analysis under multi-harmonic driving and heavy beam loading effect in J-PARC RCS

NASA Astrophysics Data System (ADS)

Yamamoto, M.; Nomura, M.; Shimada, T.; Tamura, F.; Hara, K.; Hasegawa, K.; Ohmori, C.; Toda, M.; Yoshii, M.; Schnase, A.

2016-11-01

An rf cavity in the J-PARC RCS not only covers the frequency range of a fundamental acceleration pattern but also generates multi-harmonic rf voltage because it has a broadband impedance. However, analyzing the vacuum tube operation in the case of multi-harmonics is very complicated because many variables must be solved in a self-consistent manner. We developed a method to analyze the vacuum tube operation using a well-known formula and which includes the dependence on anode current for some variables. The calculation method is verified with beam tests, and the results indicate that it is efficient under condition of multi-harmonics with a heavy beam loading effect.

Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shibata, T., E-mail: shibat@post.j-parc.jp; Ueno, A.; Oguri, H.

A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30–120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

Cryogenic system for COMET experiment at J-PARC

NASA Astrophysics Data System (ADS)

Ki, Taekyung; Yoshida, Makoto; Yang, Ye; Ogitsu, Toru; Iio, Masami; Makida, Yasuhiro; Okamura, Takahiro; Mihara, Satoshi; Nakamoto, Tatsushi; Sugano, Michinaka; Sasaki, Ken-ichi

2016-07-01

Superconducting conductors and cryogenic refrigeration are key factors in the accelerator science because they enable the production of magnets needed to control and detect the particles under study. In Japan, a system for COMET (Coherent Muon to Electron Transition), which will produce muon beam lines, is under the construction at J-PARC (Japan Proton Accelerator Research Complex). The system consists of three superconducting magnets; the first is a pion-capture solenoid, the second is a muon-transport solenoid, and the third is a detector solenoid. It is necessary to cool down the magnets efficiently using two-phase helium and maintain them securely at 4.5 K. For stable cryogenic refrigeration of the magnets, a suitable cooling method, structures, and the irradiation effect on materials should be investigated. In this paper, we focus on the development of an overall cryogenic system for cooling the capture and transport solenoids. A conduction-cooling method is considered for cooling the capture and transport solenoids because of the advantages such as the reduction of total heat load, fewer components, and simplified structure. To supply cryogenic fluids (4.5 K liquid helium and 58 K gas helium) and currents to the conduction-cooled magnets subjected to high irradiation, cryogenic components (cooling paths in the magnets, transfer tubes, and a current lead box) are developed. Based on the environment of high irradiation, the conditions (temperature and pressure) of helium in cooling paths are estimated, as well as the temperature of the capture magnet. We develop a dynamic model for quench simulation and estimate the maximum pressure in the cooling pipe when the capture magnet quenches. We conclude with a discussion of the next steps and estimated challenges for the cryogenic system.

C-band PARC manual

NASA Astrophysics Data System (ADS)

Groot, J. S.

1992-05-01

Measurement results of radar cross section, crosstalk level, etc., of a C band Polarimetric Active Radar Calibrator (PARC), which is used to calibrate air and spaceborne radars commonly used in remote sensing, are reported. The results are used to infer guidelines for the use of this PARC. The PARC consists of a high gain amplifier connected between two linearly polarized horn antennas.

Final design of the Energy-Resolved Neutron Imaging System “RADEN” at J-PARC

NASA Astrophysics Data System (ADS)

Shinohara, T.; Kai, T.; Oikawa, K.; Segawa, M.; Harada, M.; Nakatani, T.; Ooi, M.; Aizawa, K.; Sato, H.; Kamiyama, T.; Yokota, H.; Sera, T.; Mochiki, K.; Kiyanagi, Y.

2016-09-01

A new pulsed-neutron instrument, named the Energy-Resolved Neutron Imaging System “RADEN”, has been constructed at the beam line of BL22 in the Materials and Life Science Experimental Facility (MLF) of J-PARC. The primary purpose of this instrument is to perform energy-resolved neutron imaging experiments through the effective utilization of the pulsed nature of the neutron beam, making this the world's first instrument dedicated to pulsed neutron imaging experiments. RADEN was designed to cover a broad energy range: from cold neutrons with energy down to 1.05 meV (or wavelength up to 8.8 Å) with a good wavelength resolution of 0.20% to high-energy neutrons with energy of several tens keV (or wavelength of 10-3 Å). In addition, this instrument is intended to perform state-of-the-art neutron radiography and tomography experiments in Japan. Hence, a maximum beam size of 300 mm square and a high L/D value of up to 7500 are provided.

Possibility of New Precise Measurements of Muonic Helium Atom HFS at J-PARC MUSE

NASA Astrophysics Data System (ADS)

Strasser, P.; Shimomura, K.; Torii, H. A.

We propose the next generation of precision microwave spectroscopy measurements of the ground state hyperfine structure (HFS) of the muonic helium atom. The HFS interval is a sensitive tool to test three-body atomic system and bound-state QED theory as well as precise direct determination of the negative muon magnetic moment and hence its mass. Previous measurements performed in 1980s at PSI and LAMPF had uncertainties dominated by statistical errors. The new high-intensity pulsed negative muon beam at J-PARC MUSE give an opportunity to improve these measurements by nearly two orders of magnitude for the HFS interval, and almost tenfold for the negative muon mass, thus providing a more precise test of CPT invariance and determination of the negative counterpart of the anomalous g-factor for the existing BNL muon g-2 experiment. Both measurements at zero field and at high magnetic field are considered. An overview of the different aspects of these new muonic helium HFS measurements is presented.

Design of hydrogen vent line for the cryogenic hydrogen system in J-PARC

NASA Astrophysics Data System (ADS)

Tatsumoto, Hideki; Aso, Tomokazu; Kato, Takashi; Ohtsu, Kiichi; Hasegawa, Shoichi; Maekawa, Fujio; Futakawa, Masatoshi

2009-02-01

As one of the main experimental facilities in J-PARC, an intense spallation neutron source (JSNS) driven by a 1-MW proton beam selected supercritical hydrogen at a temperature of 20 K and a pressure of 1.5 MPa as a moderator material. Moderators are controlled by a cryogenic hydrogen system that has a hydrogen relief system, which consists of high and low pressure stage of manifolds, a hydrogen vent line and a stack, in order to release hydrogen to the outside safely. The design of the hydrogen vent line should be considered to prevent purge nitrogen gas in the vent line from freezing when releasing the cryogenic hydrogen, to prevent moisture in the stack placed in an outdoor location from freezing, and to inhibit large piping temperature reduction at a building wall penetration. In this work, temperature change behaviors in the hydrogen vent line were analyzed by using a CFD code, STAR-CD. We determined required sizes of the vent line based on the analytical results and its layout in the building.

Analysis of Hybrid Type Boron-Doped Carbon Stripper Foils in J-PARC RCS

NASA Astrophysics Data System (ADS)

Yamazaki, Y.; Yoshimoto, M.; Takeda, O.; Kinsho, M.; Taguchi, T.; Yamamoto, S.; Kurihara, T.; Sugai, I.

2013-03-01

J-PARC (Japan-Proton Accelerator Research Complex) requires a carbon stripper foil to strip electrons from the H- beam supplied by the linac before injection into the Rapid Cycling Synchrotron (RCS) [1]. The foil thickness is about μm (200μg/cm2) corresponding to conversion efficiency of 99.7% from the primary H- beams of 181MeV energy to H+. We have successfully developed the Hybrid type thick Boron-doped Carbon (HBC) stripper foil, which showed a drastic improvement the lifetime without thickness reduction and shrinkage at the irradiated area. We started to study carbon stripper foils microscopically why carbon foils have considerable endurance for the beam impact by boron-doped. At first step, we made a comparison of ion irradiation effect between normal carbon and HBC by the electric microscope, ion-induced analysis. In particular, it seems that grain size of boron-rich area became much larger by irradiation for HBC. It was also observed that the boron-rich grain grew up by taking around material and generated pinholes more than 100 nm near itself consequently.

Monitoring System for the Gold Target by Radiation Detectors in Hadron Experimental Facility at J-PARC

NASA Astrophysics Data System (ADS)

Muto, Ryotaro; Agari, Keizo; Aoki, Kazuya; Bessho, Kotaro; Hagiwara, Masayuki; Hirose, Erina; Ieiri, Masaharu; Iwasaki, Ruri; Katoh, Yohji; Kitagawa, Jun-ichi; Minakawa, Michifumi; Morino, Yuhei; Saito, Kiwamu; Sato, Yoshinori; Sawada, Shin'ya; Shirakabe, Yoshihisa; Suzuki, Yoshihiro; Takahashi, Hitoshi; Tanaka, Kazuhiro; Toyoda, Akihisa; Watanabe, Hiroaki; Yamanoi, Yutaka

2017-09-01

At the Hadron Experimental Facility in J-PARC, we inject a 30-GeV proton beam into a gold target to produce secondary particle beams required for various particle and nuclear physics experiments. The gold target is placed in a hermetic chamber, and helium gas is circulated in the chamber to monitor the soundness of the target. The radioactivity in helium gas is continuously monitored by gamma-ray detectors such as a germanium detector and a NaI(Tl) detector. Beam operations with those target-monitoring systems were successfully performed from April to June and October to December 2015, and from May to June 2016. In this paper, the details of the helium gas circulation system and gamma-ray detectors and the analysis results of the obtained gamma-ray spectra are reported.

Cross Section Measurements of the Radioactive 107Pd and Stable 105,108Pd Nuclei at J-PARC/MLF/ANNRI

NASA Astrophysics Data System (ADS)

Nakamura, S.; Kimura, A.; Kitatani, F.; Ohta, M.; Furutaka, K.; Goko, S.; Hara, K. Y.; Harada, H.; Hirose, K.; Kin, T.; Koizumi, M.; Oshima, M.; Toh, Y.; Kino, K.; Hiraga, F.; Kamiyama, T.; Kiyanagi, Y.; Katabuchi, T.; Mizumoto, M.; Igashira, M.; Hori, J.; Fujii, T.; Fukutani, S.; Takamiya, K.

2014-05-01

The measurements of the neutron-capture cross sections were performed for the radioactive 107Pd and stable 105,108Pd nuclei by the time-of flight method using an apparatus called “Accurate Neutron-Nucleus Reaction measurement Instrument (ANNRI)” installed at the neutron Beam Line No.4 of the Materials and Life science experimental Facility (MLF) in the J-PARC. The neutron-capture cross sections of 107Pd and 105,108Pd have been measured in the low energy region from the thermal to a few hundreds eV. From the measurements, new information was obtained for some resonances of these Pd nuclei.

DESIGN OF SUPERCONDUCTING COMBINED FUNCTION MAGNETS FOR THE 50 GEV PROTON BEAM LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

DOE Office of Scientific and Technical Information (OSTI.GOV)

WANDERER,P.; ET AL.

2003-06-15

Superconducting combined function magnets will be utilized for the 50GeV-750kW proton beam line for the J-PARC neutrino experiment and an R and D program has been launched at KEK. The magnet is designed to provide a combined function with a dipole field of 2.59 T and a quadrupole field of 18.7 T/m in a coil aperture of 173.4 mm. A single layer coil is proposed to reduce the fabrication cost and the coil arrangement in the 2-D cross-section results in left-right asymmetry. This paper reports the design study of the magnet.

Rare Kaon Decays, KEK experiment E391 and E14 at the Japan Physics and Accelerator Research Complex (J-PARC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wah, Yau Wai

2012-12-06

The goal of the J-PARC neutral kaon experiment (E14/KOTO) is to discover and measure the rate of the kaon rare decay to pi-zero and two neutrinos. This flavor changing neutral current decay proceeds through second-order weak interactions. Other, as yet undiscovered particles, which can mediate the decay could provide an enhancement (or depletion) to the branching ratio which in the Standard Model is accurately predicted within a few percent to be 2.8x10-11. The experiment is designed to observe more than 100 events at the Standard Model branching. It is a follow-up of the KEK E391a experiment and has stage-2 approvalmore » by J-PARC PAC in 2007. E14/KOTO has collaborators from Japan (Kyoto, Osaka, Yamagata, Saga), US (Arizona State, Chicago, Michigan Ann Arbor), Taiwan (National Taiwan), Korea, and Russia (Dubna). The experiment exploits the 300kW 30-50 GeV proton delivery of the J-PARC accelerator with a hermetic high acceptance detector with a fine grained Cesium Iodide (CsI) crystal calorimeter, and state of the art electronic front end and data acquisition system. With the recovery of the tsunami disaster on March 11th 2011, E14 is scheduled to start collecting data in December 2012. During the detector construction phase, Chicago focuses on the front end electronics readout of the entire detector system, particularly the CsI calorimeter. The CsI crystals together with its photomultipliers were previously used at the Fermilab KTeV experiment (E832/E799), and were loaned to E14 via this Chicago DOE support. The new readout electronics includes an innovative 10-pole pulse-shaping technique coupled with high speed digitization (14-bit 125MHz and 12-bit 500MHz). This new instrument enables us to measure both energy and timing, particularly with timing resolution better than 100 psec. Besides the cost saving by elimination of the standard time to digital converters, it is now possible to measure the momenta of the final state photons for additional background

Cryogenic System for J-Parc Neutrino Superconducting Magnet Beam LINE—DESIGN, Construction and Performance Test

NASA Astrophysics Data System (ADS)

Makida, Y.; Ohhata, H.; Okamura, T.; Suzuki, S.; Araoka, O.; Ogitsu, T.; Kimura, N.; Nakamoto, T.; Sasaki, K.; Kaneda, S.; Takahashi, T.; Ito, A.; Nagami, M.; Kumaki, T.; Nakashima, T.

2010-04-01

A helium cryogenic plant has been constructed in the proton accelerator research complex, J-PARC, to cool a string of superconducting magnets in the neutrino beam line since 2005. It consists of a screw compressor with a capacity of 160 g/s at 1.4 MPa, a 1.5 kW refrigerator, a centrifugal SHE pump with a flow rate of 300 g/s and peripherals. After system integration, performance tests have been carried out. In a preliminary cooling test without magnets, the cryogenic system attained a cooling capacity of 522 W by circulating supercritical helium flow of 300 g/s at 0.4 MPa and at 4.5 K. Afterwards a full system test with the magnets was carried out. The magnets were successfully charged up to an ultimate current of 5000 A beyond a nominal current of 4400 A. This paper describes the plant design and the result of performance measurements.

Stability test for power converters in high-powered operations for J-PARC MR main magnets

NASA Astrophysics Data System (ADS)

Morita, Yuichi; Kurimoto, Yoshinori; Miura, Kazuki; Sagawa, Ryu; Shimogawa, Tetsushi

2017-10-01

The Japan Proton Accelerator Research Complex (J-PARC) aims at achieving a megawatt-class proton accelerator facility. One promising method for increasing the beam power is to shorten the repetition cycle of the main ring from the current cycle of 2.48 s to 1.3 s. In this scheme, however, the increase in the output voltage and the power variation of the electric system are serious concerns for the power supplies of the main magnets. We have been developing a new power supply that provides solutions to these issues. Recently, we proposed a new method for high-powered tests of the converter that does not require a large-scale load and power source. We carried out a high-powered test of ∼100 kVA for the prototype DC/DC converters of the new power supply with this method. This paper introduces the design of the power supply and the results of the high-powered test for the prototype DC/DC converters.

A beam position monitor for the diagnostic line in MEBT2 of J-PARC linac

NASA Astrophysics Data System (ADS)

Miura, A.; Tamura, J.; Kawane, Y.

2017-07-01

In the linac of the Japan Proton Accelerator Research Complex (J-PARC), the neutral hydrogen (H0) beam from the negative hydrogen ion (H-) beam is one of key issues in mitigating beam losses. To diagnose H0 particles, we installed a set of beam-bump magnets to generate a chicane orbit of the H- beam. The beam position monitors (BPMs) in the beam line are used for orbit correction to maintain the beam displacement within 2.0 mm from the duct center. To measure the beam displacement under different drive currents of the beam-bump magnets, a new wide-range BPM was designed and manufactured to evaluate the horizontal beam position by using a correction function to compensate for non-linearity. We also employed the beam profile monitor (WSM: wire scanner monitor) to measure the H- beam profile, which helped us to compare the beam position measurements. In this paper, the design and the performance of the wide-range BPM are described. In addition, we present a comparison of the beam position measured by the BPM and the WSM.

Operational characteristics of the J-PARC cryogenic hydrogen system for a spallation neutron source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tatsumoto, Hideki; Ohtsu, Kiichi; Aso, Tomokazu

2014-01-29

The J-PARC cryogenic hydrogen system provides supercritical hydrogen with the para-hydrogen concentration of more than 99 % and the temperature of less than 20 K to three moderators so as to provide cold pulsed neutron beams of a higher neutronic performance. Furthermore, the temperature fluctuation of the feed hydrogen stream is required to be within ± 0.25 K. A stable 300-kW proton beam operation has been carried out since November 2012. The para-hydrogen concentrations were measured during the cool-down process. It is confirmed that para-hydrogen always exists in the equilibrium concentration because of the installation of an ortho-para hydrogen convertor.more » Propagation characteristics of temperature fluctuation were measured by temporarily changing the heater power under off-beam condition to clarify the effects of a heater control for thermal compensation on the feed temperature fluctuation. The experimental data gave an allowable temperature fluctuation of ± 1.05 K. It is clarified through a 286-kW and a 524-kW proton beam operations that the heater control would be applicable for the 1-MW proton beam operation by extrapolating from the experimental data.« less

A neutral-beam profile monitor with a phosphor screen and a high-sensitivity camera for the J-PARC KOTO experiment

NASA Astrophysics Data System (ADS)

Matsumura, T.; Kamiji, I.; Nakagiri, K.; Nanjo, H.; Nomura, T.; Sasao, N.; Shinkawa, T.; Shiomi, K.

2018-03-01

We have developed a beam-profile monitor (BPM) system to align the collimators for the neutral beam-line at the Hadron Experimental Facility of J-PARC. The system is composed of a phosphor screen and a CCD camera coupled to an image intensifier mounted on a remote control X- Y stage. The design and detailed performance studies of the BPM are presented. The monitor has a spatial resolution of better than 0.6 mm and a deviation from linearity of less than 1%. These results indicate that the BPM system meets the requirements to define collimator-edge positions for the beam-line tuning. Confirmation using the neutral beam for the KOTO experiment is also presented.

Mass production of the large-sized nuclear plate for J-PARC E07

NASA Astrophysics Data System (ADS)

Ito, Hiroki; Nakazama, Kazuma; Hoshino, Kaoru; Yoshida, Jyunya; Tint, Khin Than; Soe, Mint Kyaw; Kinbara, Shinji; Mishina, Akihiro; Endo, Yoko; Kobayashi, Hidetaka; J-PARC E07 Collaboration

2014-09-01

In J-PARC E07, about 102 double lambda hypernuclei will be detected, which is 10 times or more than that of the KEK PS-E373 experiment. Therefore, it is necessary for large-scale emulsion plates to avoid time-consuming job for exchange emulsion stack in beam exposure. We also use huge amount of emulsion gel with weight of 2.1 t, which is about 3 times' quantity used for E373. Nuclear emulsion plate is made of photographic emulsion gel as a dry film. Melted gel in 40°C is poured on a thin polystyrene film in the size of 710 × 700 mm2. These sheets were dried slowly for two days in drying cabinet under 28°C and RH. 75%. After drying, the surface was coated by thin gelatin layer with 0.3 μm thickness. Regarding the 2nd face, it was poured and coated in the same manner. Finally we dry it well under 25°C and RH. 60% and cut into four 350 × 345 mm2 plates. We evaluated the performance about these plates. The length of upper, lower, right-hand and left-hand side are 345.08 +/- 0.05 mm, 345.23 +/- 0.13 mm, 350.03 +/- 0.04 mm, and 350.80 +/- 0.05 mm, respectively. The density is 3.676 +/- 0.032 g/cm3, enough quality for the experiment.

Closeout Report - Search for Time Reversal Symmetry Violation with TREK at J-PARC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kohl, Michael

2015-04-15

This DOE Early Career Award has enabled Dr. Michael Kohl to take on and expand his leadership roles in several projects such as TREK@J-PARC, OLYMPUS@DESY, MUSE@PSI, and in the experimental program in Hall C at Jefferson Lab. Dr. Kohl has successfully accomplished several items: (i) Preliminary results from SANE (E08-003) at Jefferson Lab: Former HU graduate student Anusha Liyanage has pursued her PhD research on SANE. Her analysis of the elastic ep scattering data has resulted in the extraction of the proton electric-to-magnetic form factor ratio from double spin asymmetries at the highest momentum transfer to date. The results aremore » almost final and a publication is in preparation. (ii) Approval of TREK/E36 for running, preparation of simulation and analysis: the TREK experiment has been stage-II approved in fall 2013, has been mounted on the hall floor from November 2014 to April 2015, has been commissioned in April-June 2015 and is scheduled to run in fall 2015. The group has contributed significantly with simulations and magnetic field map calculations, has investigated the sensitivity of TREK to new light neutral particles, and contributed substantially to the mounting and commissioning of the experiment. (iii) Running of OLYMPUS and analysis: Under Dr. Kohl's leadership as spokesman, the OLYMPUS experiment has completed data taking beginning of 2013; calibrations and analysis have been well underway, with results to be expected in the course of 2015. (iv) Operation of GEM detectors at OLYMPUS and MUSE: The GEM telescopes built for OLYMPUS luminosity monitoring with forward-angle ep elastic scattering have been operated successfully, have meanwhile been relocated to PSI, and have been re-commissioned as beam particle trackers for the PSI secondary beams for MUSE. (v) Trained and prepared postdocs and graduate students for their future careers. Two postdocs from Dr. Kohl's group (Dr. Juergen Diefenbach and Dr. Peter Monaghan) have found permanent academic

Double-layer effects on the lifetime of newly developed HBC-foils for RCS of J-PARC

NASA Astrophysics Data System (ADS)

Sugai, I.; Takeda, Y.; Oyaizu, M.; Kawakami, H.; Irie, Y.; Takagi, A.; Hattori, H.; Kawasaki, K.

2010-02-01

We have developed hybrid type boron-mixed carbon (HBC) foils for the rapid cycling synchrotron (RCS) of Japan-proton accelerator research complex (J-PARC) using the controlled DC arc-discharge method. The method has been found suitable for the production of thick foils up to a maximum of 700 μg/cm 2 due to the strong adhesion to the substrate. The foils thus produced showed rather long lifetime. By the development, high-temperature damage (foil deformation, thickness reduction and pinhole formation) of the foil was significantly mitigated even at a temperature of approximately 1700 K. However, when the foil temperature was higher than about 1800 K, especially pinhole formation in the irradiated area of the foil and its peripheries were always observed. In order to relieve high-temperature damage, we investigated the possibility to lower the temperature rise in single and double layer HBC-foils while keeping the total thickness the same. We also compared the lifetime of the single and the double layer HBC-foils as well as diamond and commercially available foils, using a 3.2 MeV Ne + ion beam from the Van de Graaff accelerator.

Characterization of germanium detectors for the measurement of the angular distribution of prompt γ-rays at the ANNRI in the MLF of the J-PARC

NASA Astrophysics Data System (ADS)

Takada, S.; Okudaira, T.; Goto, F.; Hirota, K.; Kimura, A.; Kitaguchi, M.; Koga, J.; Nakao, T.; Sakai, K.; Shimizu, H. M.; Yamamoto, T.; Yoshioka, T.

2018-02-01

In this study, the germanium detector assembly, installed at the Accurate Neutron-Nuclear Reaction measurement Instruments (ANNRI) in the Material and Life Science Facility (MLF) operated by the Japan Proton Accelerator Research Complex (J-PARC), has been characterized for extension to the measurement of the angular distribution of individual γ-ray transitions from neutron-induced compound states. We have developed a Monte Carlo simulation code using the GEANT4 toolkit, which can reproduce the pulse-height spectra of γ-rays from radioactive sources and (n,γ) reactions. The simulation is applicable to the measurement of γ-rays in the energy region of 0.5-11.0 MeV.

Performance of a superconducting magnet system operated in the Super Omega Muon beam line at J-PARC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makida, Yasuhiro; Ikedo, Yutaka; Ogitsu, Toru

A superconducting magnet system, which is composed of an 8 m long solenoid for transportation and 12 short solenoids for focusing, has been developed for Muon Science Establishment facility of J-PARC. The transport solenoid is composed of a 6 m straight section connected to a 45 degree curved section at each end. Muons of various momenta and of both electric charges are transported through the solenoid inner bore with an effective diameter of 0.3 m, where 2 T magnetic field is induced. There are 12 focusing solenoids with an effective bore diameter of 0.6 m and a length of 0.35more » m arranged on a straight line at suitable intervals. The maximum central field of each focusing solenoid is 0.66 T. All solenoid coils are cooled by GM cryocoolers through their own conductions. The magnet system has been installed into the beam line in the summer of 2012, and its performance has been checked. Beam commissioning has been carried out since October 2012. During beam operation, temperature rise over 6 K in the transport solenoid due to a nuclear heating from the muon production target is observed at beam intensity of about 300 kW.« less

New data acquisition system for beam loss monitor used in J-PARC main ring

NASA Astrophysics Data System (ADS)

Satou, K.; Toyama, T.; Kamikubota, N.; Yoshida, S.; Matsushita, J.; Wakita, T.; Sugiyama, M.; Morino, T.

2018-04-01

A new data acquisition system has been developed continually as a part of the development of a new beam loss monitor (BLM) system for the J-PARC main ring. This development includes a newly designed front-end isolation amp that uses photo-couplers and a VME-based new analog-to-digital converter (ADC) system. Compared to the old amp, the new amp has a 10 times higher conversion impedance for the input current to the output voltage; this value is 1 M Ω. Moreover, the bandwidth was improved to from DC to 50 kHz, which is about two orders of magnitude greater than the previously used bandwidth. The theoretical estimations made in this study roughly agree with the frequency response obtained for the new system. The new ADC system uses an on-board field-programmable gate array chip for signal processing. By replacing the firmware of this chip, changes pertaining to future accelerator upgrade plans may be introduced into the new ADC system; in addition, the ADC system can be used in other applications. The sampling speed of the system is 1 MS/s, and it exhibits a 95 dBc spurious-free dynamic range and 16.5 effective number of bits. The obtained waveform and integrated charge data are compared with two reference levels in the ADC system. If the data exceeds the reference level, the system generates an alarm to dump the beams. By using the new data acquisition system, it was proved that the new BLM system shows a wide dynamic range of 160 dB. In this study, the details of the new data acquisition system are described.

Event Recording Data Acquisition System and Experiment Data Management System for Neutron Experiments at MLF, J-PARC

NASA Astrophysics Data System (ADS)

Nakatani, T.; Inamura, Y.; Moriyama, K.; Ito, T.; Muto, S.; Otomo, T.

Neutron scattering can be a powerful probe in the investigation of many phenomena in the materials and life sciences. The Materials and Life Science Experimental Facility (MLF) at the Japan Proton Accelerator Research Complex (J-PARC) is a leading center of experimental neutron science and boasts one of the most intense pulsed neutron sources in the world. The MLF currently has 18 experimental instruments in operation that support a wide variety of users from across a range of research fields. The instruments include optical elements, sample environment apparatus and detector systems that are controlled and monitored electronically throughout an experiment. Signals from these components and those from the neutron source are converted into a digital format by the data acquisition (DAQ) electronics and recorded as time-tagged event data in the DAQ computers using "DAQ-Middleware". Operating in event mode, the DAQ system produces extremely large data files (˜GB) under various measurement conditions. Simultaneously, the measurement meta-data indicating each measurement condition is recorded in XML format by the MLF control software framework "IROHA". These measurement event data and meta-data are collected in the MLF common storage and cataloged by the MLF Experimental Database (MLF EXP-DB) based on a commercial XML database. The system provides a web interface for users to manage and remotely analyze experimental data.

Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease.

PubMed

Sin, Don D; Miller, Bruce E; Duvoix, Annelyse; Man, S F Paul; Zhang, Xuekui; Silverman, Edwin K; Connett, John E; Anthonisen, Nicholas A; Wise, Robert A; Tashkin, Donald; Celli, Bartolome R; Edwards, Lisa D; Locantore, Nicholas; Macnee, William; Tal-Singer, Ruth; Lomas, David A

2011-05-01

There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality. PARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study. Serum PARC/CCL-18 levels were higher in subjects with COPD than in smokers or lifetime nonsmokers without COPD (105 vs. 81 vs. 80 ng/ml, respectively; P < 0.0001). Elevated PARC/CCL-18 levels were associated with increased risk of cardiovascular hospitalization or mortality in the LHS cohort and with total mortality in the ECLIPSE cohort. Serum PARC/CCL-18 levels are elevated in COPD and track clinical outcomes. PARC/CCL-18, a lung-predominant chemokine, could be a useful blood biomarker in COPD.

Serum PARC/CCL-18 Concentrations and Health Outcomes in Chronic Obstructive Pulmonary Disease

PubMed Central

Sin, Don D.; Miller, Bruce E.; Duvoix, Annelyse; Man, S. F. Paul; Zhang, Xuekui; Silverman, Edwin K.; Connett, John E.; Anthonisen, Nicholas A.; Wise, Robert A.; Tashkin, Donald; Celli, Bartolome R.; Edwards, Lisa D.; Locantore, Nicholas; MacNee, William; Tal-Singer, Ruth; Lomas, David A.

2011-01-01

Rationale: There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. Objectives: To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality. Methods: PARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study. Measurements and Main Results: Serum PARC/CCL-18 levels were higher in subjects with COPD than in smokers or lifetime nonsmokers without COPD (105 vs. 81 vs. 80 ng/ml, respectively; P < 0.0001). Elevated PARC/CCL-18 levels were associated with increased risk of cardiovascular hospitalization or mortality in the LHS cohort and with total mortality in the ECLIPSE cohort. Conclusions: Serum PARC/CCL-18 levels are elevated in COPD and track clinical outcomes. PARC/CCL-18, a lung-predominant chemokine, could be a useful blood biomarker in COPD. Clinical trial registered with www.clinicaltrials.gov (NCT 00292552). PMID:21216880

Energy resolution of pulsed neutron beam provided by the ANNRI beamline at the J-PARC/MLF

NASA Astrophysics Data System (ADS)

Kino, K.; Furusaka, M.; Hiraga, F.; Kamiyama, T.; Kiyanagi, Y.; Furutaka, K.; Goko, S.; Hara, K. Y.; Harada, H.; Harada, M.; Hirose, K.; Kai, T.; Kimura, A.; Kin, T.; Kitatani, F.; Koizumi, M.; Maekawa, F.; Meigo, S.; Nakamura, S.; Ooi, M.; Ohta, M.; Oshima, M.; Toh, Y.; Igashira, M.; Katabuchi, T.; Mizumoto, M.; Hori, J.

2014-02-01

We studied the energy resolution of the pulsed neutron beam of the Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) at the Japan Proton Accelerator Research Complex/Materials and Life Science Experimental Facility (J-PARC/MLF). A simulation in the energy region from 0.7 meV to 1 MeV was performed and measurements were made at thermal (0.76-62 meV) and epithermal energies (4.8-410 eV). The neutron energy resolution of ANNRI determined by the time-of-flight technique depends on the time structure of the neutron pulse. We obtained the neutron energy resolution as a function of the neutron energy by the simulation in the two operation modes of the neutron source: double- and single-bunch modes. In double-bunch mode, the resolution deteriorates above about 10 eV because the time structure of the neutron pulse splits into two peaks. The time structures at 13 energy points from measurements in the thermal energy region agree with those of the simulation. In the epithermal energy region, the time structures at 17 energy points were obtained from measurements and agree with those of the simulation. The FWHM values of the time structures by the simulation and measurements were found to be almost consistent. In the single-bunch mode, the energy resolution is better than about 1% between 1 meV and 10 keV at a neutron source operation of 17.5 kW. These results confirm the energy resolution of the pulsed neutron beam produced by the ANNRI beamline.

Naval Research Laboratory Multiscale Targeting Guidance for T-PARC and TCS-08

DTIC Science & Technology

2010-01-01

Naval Research Laboratory Multiscale Targeting Guidance for T- PARC and TCS-08 CAROLYN A. REYNOLDS AND JAMES D. DOYLE Marine Meteorology Division...of The Observing System Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaign (T- PARC ) and the Office of Naval Research’s...These products were produced with 24-, 36-, and 48-h lead times. The nonhydrostatic adjoint system used during T- PARC /TCS-08 contains an exact adjoint to

Measurement of the neutron capture resonances for platinum using the Ge spectrometer and pulsed neutron beam at the J-PARC/MLF/ANNRI

NASA Astrophysics Data System (ADS)

Kino, Koichi; Hasemi, Hiroyuki; Kimura, Atsushi; Kiyanagi, Yoshiaki

2017-09-01

The neutron capture cross-section for platinum was measured at J-PARC/MLF/ANNRI. The intense pulsed neutron beam was impinging on a natural platinum foil sample and the emitted prompt γ-rays were detected by a Ge spectrometer. The peak energies of the low energy resonances for natural platinum are consistent with those of the JEFF-3.1.2, RUSFOND2010 and next-JENDL data libraries except for the 20-eV resonance. The resonance cross-sections of the next-JENDL library do not contradict the present measurements within the uncertainty of the absolute value of the present work. We analysed the prompt γ-ray spectrum and found a clear 7921.93 keV peak that originates from the transition from the 196Pt compound state to its ground state. The neutron capture cross-section for 195Pt was obtained by choosing events of this peak. The peak energies of most of the low energy resonances are almost consistent with those of the RUSFOND2010 and next-JENDL libraries. However, there was a disagreement for the 20-eV resonance.

Physics potential of a long-baseline neutrino oscillation experiment using a J-PARC neutrino beam and Hyper-Kamiokande

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abe, K.; Aihara, H.; Andreopoulos, C.

Hyper-Kamiokande will be a next generation underground water Cherenkov detector with a total (fiducial) mass of 0.99 (0.56) million metric tons, approximately 20 (25) times larger than that of Super-Kamiokande. One of the main goals of Hyper-Kamiokande is the study of CP asymmetry in the lepton sector using accelerator neutrino and anti-neutrino beams. In this paper, the physics potential of a long baseline neutrino experiment using the Hyper-Kamiokande detector and a neutrino beam from the J-PARC proton synchrotron is presented. The analysis uses the framework and systematic uncertainties derived from the ongoing T2K experiment. With a total exposure of 7.5more » MW × 107 sec integrated proton beam power (corresponding to 1.56×1022 protons on target with a 30 GeV proton beam) to a 2.5-degree off-axis neutrino beam, it is expected that the leptonic CP phase δCP can be determined to better than 19 degrees for all possible values of δCP, and CP violation can be established with a statistical significance of more than 3σ (5σ) for 76% (58%) of the δCP parameter space. Using both νe appearance and νμ disappearance data, the expected 1σ uncertainty of sin2θ23 is 0.015(0.006) for sin2θ23=0.5(0.45).« less

Physics potential of a long-baseline neutrino oscillation experiment using a J-PARC neutrino beam and Hyper-Kamiokande

DOE PAGES

Abe, K.; Aihara, H.; Andreopoulos, C.; ...

2015-05-19

Hyper-Kamiokande will be a next generation underground water Cherenkov detector with a total (fiducial) mass of 0.99 (0.56) million metric tons, approximately 20 (25) times larger than that of Super-Kamiokande. One of the main goals of Hyper-Kamiokande is the study of CP asymmetry in the lepton sector using accelerator neutrino and anti-neutrino beams. In this paper, the physics potential of a long baseline neutrino experiment using the Hyper-Kamiokande detector and a neutrino beam from the J-PARC proton synchrotron is presented. The analysis uses the framework and systematic uncertainties derived from the ongoing T2K experiment. With a total exposure of 7.5more » MW × 107 sec integrated proton beam power (corresponding to 1.56×1022 protons on target with a 30 GeV proton beam) to a 2.5-degree off-axis neutrino beam, it is expected that the leptonic CP phase δCP can be determined to better than 19 degrees for all possible values of δCP, and CP violation can be established with a statistical significance of more than 3σ (5σ) for 76% (58%) of the δCP parameter space. Using both νe appearance and νμ disappearance data, the expected 1σ uncertainty of sin2θ23 is 0.015(0.006) for sin2θ23=0.5(0.45).« less

Science Goals for the PARCS mission on the International Space Station

NASA Astrophysics Data System (ADS)

Ashby, Neil; Hollberg, Leo; Jefferts, Steven; Klipstein, William; Seidel, David; Sullivan, Donald

2003-05-01

The PARCS (Primary Atomic Reference Clock in Space) experiment will use a laser-cooled cesium atomic clock operating in the microgravity environment aboard the International Space Station (ISS) to provide both advanced tests of gravitational theory and to demonstrate a new cold-atom clock technology for space. This presentation concentrates on the scientific goals of the PARCS mission. The microgravity space environment allows laser-cooled Cs atoms to have Ramsey times in excess of those feasible on Earth, resulting in improved clock performance. Clock stabilities of 5×10-14 at one second, and uncertainties below 10-16 are projected. The relativistic frequency shift should be measurable at least 40 times better than the previous best measurement made by Gravity Probe A. Significant improvements in testing fundamental assumptions of relativity theory, such as local position invariance (LPI), are expected. PARCS is scheduled for launch in 2007 and may very well fly with the Stanford superconducting microwave oscillator (SUMO) which will allow a Kennedy-Thorndike-type experiment with an improvement of better than three orders of magnitude compared to previous best results. PARCS will also provide a much-improved realization of the second, and a stable time reference in space. PARCS is a joint project by the National Institue of Standards and Technology (NIST), the University of Colorado (CU) and NASA's Jet Propulsion Laboratory (JPL).

Development and Validation of a Novel Pediatric Appendicitis Risk Calculator (pARC).

PubMed

Kharbanda, Anupam B; Vazquez-Benitez, Gabriela; Ballard, Dustin W; Vinson, David R; Chettipally, Uli K; Kene, Mamata V; Dehmer, Steven P; Bachur, Richard G; Dayan, Peter S; Kuppermann, Nathan; O'Connor, Patrick J; Kharbanda, Elyse O

2018-04-01

We sought to develop and validate a clinical calculator that can be used to quantify risk for appendicitis on a continuous scale for patients with acute abdominal pain. The pediatric appendicitis risk calculator (pARC) was developed and validated through secondary analyses of 3 distinct cohorts. The derivation sample included visits to 9 pediatric emergency departments between March 2009 and April 2010. The validation sample included visits to a single pediatric emergency department from 2003 to 2004 and 2013 to 2015. Variables evaluated were as follows: age, sex, temperature, nausea and/or vomiting, pain duration, pain location, pain with walking, pain migration, guarding, white blood cell count, and absolute neutrophil count. We used stepwise regression to develop and select the best model. Test performance of the pARC was compared with the Pediatric Appendicitis Score (PAS). The derivation sample included 2423 children, 40% of whom had appendicitis. The validation sample included 1426 children, 35% of whom had appendicitis. The final pARC model included the following variables: sex, age, duration of pain, guarding, pain migration, maximal tenderness in the right-lower quadrant, and absolute neutrophil count. In the validation sample, the pARC exhibited near perfect calibration and a high degree of discrimination (area under the curve: 0.85; 95% confidence interval: 0.83 to 0.87) and outperformed the PAS (area under the curve: 0.77; 95% confidence interval: 0.75 to 0.80). By using the pARC, almost half of patients in the validation cohort could be accurately classified as at <15% risk or ≥85% risk for appendicitis, whereas only 23% would be identified as having a comparable PAS of <3 or >8. In our validation cohort of patients with acute abdominal pain, the pARC accurately quantified risk for appendicitis. Copyright © 2018 by the American Academy of Pediatrics.

Science Goals of the Primary Atomic Reference Clock in Space (PARCS) Experiment

NASA Technical Reports Server (NTRS)

Ashby, N.

2003-01-01

The PARCS (Primary Atomic Reference Clock in Space) experiment will use a laser-cooled Cesium atomic clock operating in the microgravity environment aboard the International Space Station (ISS) to provide both advanced tests of gravitational theory and to demonstrate a new cold-atom clock technology for space. PARCS is a joint project of the National Institute of Standards and Technology (NIST), NASA's Jet Propulsion Laboratory (JPL), and the University of Colorado (CU). This paper concentrates on the scientific goals of the PARCS mission. The microgravity space environment allows laser-cooled Cs atoms to have Ramsey times in excess of those feasible on Earth, resulting in improved clock performance. Clock stabilities of 5x10(exp -14) at one second, and accuracies better than 10(exp -16) are projected.

Annual Report: 2014: Partners in Amphibian and Reptile Conservation (PARC)

USGS Publications Warehouse

Weir, Linda A.; Nanjappa, P.; Apodaca, J.J.; Williams, J.

2015-01-01

Partners in Amphibian and Reptile Conservation (PARC) was established in 1999 to address the widespread declines, extinctions, and range reductions of amphibians and reptiles, with a focus on conservation of taxa and habitats in North America. Amphibians and reptiles are affected by a broad range of human activities, both as incidental effects of habitat alteration and direct effects from overexploitation; these animals are also burdened by humans attitudes – that amphibians and reptiles are either dangerous or of little environmental or economic value. However, PARC members understand these taxa are important parts of our natural and cultural heritage and they serve important roles in ecosystems throughout the world. With many amphibians and reptiles classified as threatened with extinction, conservation to ensure healthy populations of these animals has never been more important. As you will see herein, PARC’s 15th anniversary has been marked with major accomplishments and an ever-increasing momentum. With your help, PARC can continue to build on its successes and protect these vital species.

Thermal analysis of injection beam dump of high-intensity rapid-cycling synchrotron in J-PARC

NASA Astrophysics Data System (ADS)

Kamiya, J.; Saha, P. K.; Yamamoto, K.; Kinsho, M.; Nihei, T.

2017-10-01

The beam dump at the beam injection area in the J-PARC 3-GeV rapid cycling synchrotron (RCS) accepts beams that pass through the charge exchange foil without ideal electron stripping during the multi-turn beam injection. The injection beam dump consists of the beam pipe, beam stopper, radiation shield, and cooling mechanism. The ideal beam power into the injection beam dump is 400 W in the case of design RCS extraction beam power of 1 MW with a healthy foil, which has 99.7 % charge stripping efficiency. On the other hand, as a radiation generator, the RCS is permitted to be operated with maximum average beam power of 4 kW into the injection beam dump based on the radiation shielding calculation, in consideration of lower charge stripping efficiency due to the foil deterioration. In this research, to evaluate the health of the RCS injection beam dump system from the perspective of the heat generation, a thermal analysis was performed based on the actual configuration with sufficiently large region, including the surrounding concrete and soil. The calculated temperature and heat flux density distribution showed the validity of the mesh spacing and model range. The calculation result showed that the dumped 4 kW beam causes the temperature to increase up to 330, 400, and 140 °C at the beam pipe, beam stopper, and radiation shield, respectively. Although these high temperatures induce stress in the constituent materials, the calculated stress values were lower than the ultimate tensile strength of each material. Transient temperature analysis of the beam stopper, which simulated the sudden break of the charge stripper foil, demonstrated that one bunched beam pulse with the maximum beam power does not lead to a serious rise in the temperature of the beam stopper. Furthermore, from the measured outgassing rate of stainless steel at high temperature, the rise in beam line pressure due to additive outgassing from the heated beam pipe was estimated to have a negligible

Dynamique des ressources naturelles dans le Parc national de Manda: Cartographie et analyse pour le Développement durable

NASA Astrophysics Data System (ADS)

Ballah Solkam, Rosalie; Médard, Ndoutorlengar

2018-05-01

Au Tchad, le réseau d'aires protégées couvre près de 10,2% de la surface du pays et reste globalement représentatif de toute la diversité des écosystèmes de la région. Cependant, ce réseau n'est pas constitué d'écosystèmes intacts car de nombreuses altérations y ont été apportés (certaines espèces sont déjà au seuil critique d'extinction (Addax, gazelle dama, lamantin), voire ont disparu (Rhinocéros noir et blanc, Oryx)) surtout dans les parcs nationaux. Ce qui nous amène à nous interroger sur la dynamique des ressources naturelles et le degré de conservation du parc national de Manda? Une évaluation de la diversité biologique et des ressources hydrographiques de 1951 à 1999 sur la base de la bibliographie existante, de la carte topographique de 1956, des images satellitaires Landsat 5 et 7 TM et ETM+ de 2 périodes (1986, 1999), complétée par des interviews semi-structurés et des transects sur le terrain, permettra de mieux appréhender la dynamique des ressources et les actions de conservation de la biodiversité réalisées à cet effet. Les résultats montrent une dynamique progressive de la faune de 1951 à 1970, puis une dynamique régressive de 1970 à 1989. Après cette tumultueuse période, un repeuplement du parc s'opère de 1989 à 2002. Par contre, la flore est relativement bien conservée avec quelques cours d'eau, des mares, champs et plantations. Et cela grâce aux multiples projets de conservation de la biodiversité. La promotion de l'écotourisme serait une alternative au développement durable de ce parc.

Characterization of a point mutation in the parC gene of Mycoplasma bovirhinis associated with fluoroquinolone resistance.

PubMed

Hirose, K; Kawasaki, Y; Kotani, K; Abiko, K; Sato, H

2004-05-01

Quinolone-resistant (QR) mutants of Mycoplasma bovirhinis strain PG43 (type strain) were generated by stepwise selection in increasing concentrations of enrofloxacin (ENR). An alteration was found in the quinolone resistance-determining region (QRDR) of the parC gene coding for the ParC subunit of topoisomerase IV from these mutants, but not in the gyrA, gyrB, and parE gene coding for the GyrA and GyrB subunits of DNA gyrase and the ParE subunit of topoisomerase IV. Similarly, such an alteration in QRDR of parC was found in the field isolates of M. bovirhinis, which possessed various levels of QR. The substitution of leucine (Leu) by serine (Ser) at position 80 of QRDR of ParC was observed in both QR-mutants and QR-isolates. This is the first report of QR based on a point mutation of the parC gene in M. bovirhinis.

PARC Navier-Stokes code upgrade and validation for high speed aeroheating predictions

NASA Technical Reports Server (NTRS)

Liver, Peter A.; Praharaj, Sarat C.; Seaford, C. Mark

1990-01-01

Applications of the PARC full Navier-Stokes code for hypersonic flowfield and aeroheating predictions around blunt bodies such as the Aeroassist Flight Experiment (AFE) and Aeroassisted Orbital Transfer Vehicle (AOTV) are evaluated. Two-dimensional/axisymmetric and three-dimensional perfect gas versions of the code were upgraded and tested against benchmark wind tunnel cases of hemisphere-cylinder, three-dimensional AFE forebody, and axisymmetric AFE and AOTV aerobrake/wake flowfields. PARC calculations are in good agreement with experimental data and results of similar computer codes. Difficulties encountered in flowfield and heat transfer predictions due to effects of grid density, boundary conditions such as singular stagnation line axis and artificial dissipation terms are presented together with subsequent improvements made to the code. The experience gained with the perfect gas code is being currently utilized in applications of an equilibrium air real gas PARC version developed at REMTECH.

Design concept for the microwave interrogation structure in PARCS

NASA Technical Reports Server (NTRS)

Dick, G. J.; Klipstein, W. M.; Heavner, T. P.; Jefferts, S. R.

2002-01-01

In this paper we will describe key aspects of the conceptual design of the microwave interrogation structure in the laser-cooled cesium frequency standard that is part of the Primary Atomic Reference Clock in Space (PARCS) experiment.

A Design for Living: The PARC Plan. Report of the PARC Ad Hoc Planning Committee for Resolution II, October 19, 1974.

ERIC Educational Resources Information Center

Pennsylvania Association for Retarded Citizens, Harrisburg.

Presented is the PARC (Pennsylvania Association for Retarded Citizens) Plan which resulted from a 3-month survey of Pennsylvania's institutional system and which was designed to improve living conditions and programs of state schools and hospitals serving the mentally retarded. Detailed are specific recommendations for the achievement of annual…

PARCS-Primary Atomic Reference Clock in Space

NASA Astrophysics Data System (ADS)

Ashby, Neil

2000-04-01

The purpose of the PARCS project is to place an advanced Cesium clock on the International Space Station (ISS). The project has been approved by NASA at the level of Science Concept Review. Groups at the National Institute of Standards and Technology, Jet Propulsion Laboratory, University of Colorado, and Harvard-Smithsonian Astrophysical Observatory, University of Torino are collaborating on clock design and construction. The microgravity space environment allows laser-cooled Cs atoms to spend longer times in the beam, resulting in improved clock performance. Clock stabilities of 3 × 10-14 at one second and accuracies of 1 × 10-16 are projected. With improved clock performance, significant improvements in several fundamental special and general relativity experiments are expected. For an ISS orbit at 400 km altitude and eccentricity 0.02, the gravitational frequency shift should be measureable about 35 times better than the previous best, Gravity Probe A. Improvements in testing Local Position Invariance and in a Kennedy-Thorndike experiment are expected. Areas of technology such as world-wide timing and time transfer and navigation will also directly benefit from such a high-performance clock in space. This paper will briefly describe the PARCS clock. The principal limitations on performance of relativity experiments, scientific objectives and benefits, and projected outcomes, will be discussed.

NORAD's PARCS small satellite tests (1976 and 1978)

NASA Technical Reports Server (NTRS)

Kessler, D. J.

1985-01-01

NORAD sponsored small satellite tests in 1976 and 1978. The purpose of the tests was to use their more sensitive radar to determine the number of Earth orbiting objects which are not part of the official catalogue. Both tests used the PARCS radar. The characteristics of this radar are given. The detection capability of NORAD's operational system is estimated and compared to the PARC's radar sensitivity during these tests. The tests only slightly improved the detection capability, and the largest improvements were at the lowest and highest regions of its sensitivity range. The major conclusion of the test is that 17.7% of the objects detected were uncorrelated (i.e., not in the official catalogue). However, perhaps most significant is the altitutde and size distribution of detected objects are illustrated. The 1978 results are also summarized. This test concluded that at least 7% of the objects detected were not in the official catalogue. Another 6% of the detected objects were not tracked well enough to determine their status. Again, a large percentage of the detected objects at lower altitudes were not in the catalogue.

NORAD's PARCS small satellite tests (1976 and 1978)

NASA Astrophysics Data System (ADS)

Kessler, D. J.

1985-03-01

NORAD sponsored small satellite tests in 1976 and 1978. The purpose of the tests was to use their more sensitive radar to determine the number of Earth orbiting objects which are not part of the official catalogue. Both tests used the PARCS radar. The characteristics of this radar are given. The detection capability of NORAD's operational system is estimated and compared to the PARC's radar sensitivity during these tests. The tests only slightly improved the detection capability, and the largest improvements were at the lowest and highest regions of its sensitivity range. The major conclusion of the test is that 17.7% of the objects detected were uncorrelated (i.e., not in the official catalogue). However, perhaps most significant is the altitutde and size distribution of detected objects are illustrated. The 1978 results are also summarized. This test concluded that at least 7% of the objects detected were not in the official catalogue. Another 6% of the detected objects were not tracked well enough to determine their status. Again, a large percentage of the detected objects at lower altitudes were not in the catalogue.

Code Development in Coupled PARCS/RELAP5 for Supercritical Water Reactor

DOE PAGES

Hu, Po; Wilson, Paul

2014-01-01

The new capability is added to the existing coupled code package PARCS/RELAP5, in order to analyze SCWR design under supercritical pressure with the separated water coolant and moderator channels. This expansion is carried out on both codes. In PARCS, modification is focused on extending the water property tables to supercritical pressure, modifying the variable mapping input file and related code module for processing thermal-hydraulic information from separated coolant/moderator channels, and modifying neutronics feedback module to deal with the separated coolant/moderator channels. In RELAP5, modification is focused on incorporating more accurate water properties near SCWR operation/transient pressure and temperature in themore » code. Confirming tests of the modifications is presented and the major analyzing results from the extended codes package are summarized.« less

Measurements and PHITS Monte Carlo Estimations of Residual Activities Induced by the 181 MeV Proton Beam in the Injection Area at J-PARC RCS Ring

NASA Astrophysics Data System (ADS)

Yamakawa, Emi; Yoshimoto, Masahiro; Kinsho, Michikazu

At the injection area of the RCS ring in the J-PARC, residual gamma dose at the rectangular ceramic ducts, especially immediately downstream of the charge-exchanged foil, has increased with the output beam power. In order to investigate the cause of high residual activities, residual gamma dose and radioactive sources produced at the exterior surface of the ducts have been measured by a GM survey meter and a handy type of Germanium (Ge) semiconductor detector in the case of 181 MeV injected proton beam energy. With these measurements, it is revealed that the radioactive sources produced by nuclear reactions cause the high activities at the injection area. For a better understanding of phenomena in the injection area, various simulations have been done with the PHITS Monte Carlo code. The distribution of radioactive sources and residual gamma dose rate obtained by the calculations are consistent with the measurement results. With this consistency, secondary neutrons and protons derived from nuclear reactions at the charge-exchanged foil are the dominant cause to high residual gamma dose at the ceramic ducts in the injection area. These measurements and calculations are unique approaches to reveal the cause of high residual dose around the foil. This study is essential for the future of high-intensity proton accelerators using a stripping foil.

ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype.

PubMed Central

Muñoz, R; De La Campa, A G

1996-01-01

The genes encoding the ParC and ParE subunits of topoisomerase IV of Streptococcus pneumoniae, together with the region encoding amino acids 46 to 172 (residue numbers are as in Escherichia coli) of the pneumococcal GyrA subunit, were partially characterized. The gyrA gene maps to a physical location distant from the gyrB and parC loci on the chromosome, whereas parC is closely linked to parE. Ciprofloxacin-resistant (Cpr) clinical isolates of S. pneumoniae had mutations affecting amino acid residues of the quinolone resistance-determining region of ParC (low-level Cpr) or in both quinolone resistance-determining regions of ParC and GyrA (high-level Cpr). Mutations were found in residue positions equivalent to the serine at position 83 and the aspartic acid at position 87 of the E. coli GyrA subunit. Transformation experiments suggest that ParC is the primary target of ciprofloxacin. Mutation in parC appears to be a prerequisite before mutations in gyrA can influence resistance levels. PMID:8891124

[Mutations of gyrA gene and parC gene in fluoroquinolone-resistant Escherichia coli isolates from sporadic diarrheal cases].

PubMed

Ishiguro, Fubito; Toho, Miho; Yamazaki, Mitsugu; Matsuyuki, Seiko; Moriya, Kazuo; Tanaka, Daisuke; Isobe, Junko; Kyota, Yoshito; Muraoka, Michio

2006-09-01

We studied 107 isolates of Escherichia coli O153 from sporadic diarrhea cases in Fukui, Toyama, Aichi, and Saga prefectures from 1991 to 2005 for antimicrobial susceptibility and mechanisms of fluoroquinolone resistance, based on standard disk diffusion. Of 12 drugs tested, ampicillin displayed resistance to 72.9% of isolates, streptomycin to 48.6%, tetracycline to 46.7%, sulfisoxazole to 46.7%, trimethoprim/sulfamethoxazole to 29.9%, nalidixic acid (NA) to 29.9%, and ciprofloxacin (CPFX) to 24.3%. Ten of 32 isolates resistant to 3-6 drugs and 16 of 18 isolates resistant to 7-10 drugs were resistant both to NA and CPFX. Mutations of amino acid in quinolone resistance-determining regions of gyrA and parC genes were detected in 24 isolates resistant both to NA and CPFX, and in 1 isolate resistant to NA. The former possessed a combination of double substitution (S83L and D87L) in GyrA and a single substitution (S80I) in ParC. Some 12 of 24 isolates possessed another single substitution (E84V or E84G or A108T) in ParC. The 25 isolates were classified into 4 types as follows. 1 isolate as type 1: GyrA (S83L) and ParC (S80I); 12 isolates as type 2: GyrA (S83L and D87N) and ParC (S80I); 8 isolates as type 3: GyrA (S83L and D87N) and ParC (S80I and E84G/S80R and E84V); and 4 isolate as type 4: GyrA (S83L and D87N) and ParC (S80I and A108T). In the relationship between amino acid mutations and minimal inhibitory concentrations (MIC) of fluoroquinolone, MICs of CPFX, ofloxacin, and norfloxacin showed 1microg/mL, 2microg/mL and 8microg/mL in type 1; 8 approximately 32microg/mL, 8 approximately 32microg/mL and 16 approximately 256microg/mL in type 2; and 32 approximately 256microg/mL' 32 approximately 128microg/mL and 128-->512microg/ mL in types 3 and 4. These results suggest that most of multiple-antimicrobial-resitant E. coli O153 isolates from sporadic diarrhea cases were resistant to fluoroquinolones and possessed mutations at gyrA and parC genes associated with

Use of the PARC code to estimate the off-design transonic performance of an over/under turboramjet nozzle

NASA Technical Reports Server (NTRS)

Lam, David W.

1995-01-01

The transonic performance of a dual-throat, single-expansion-ramp nozzle (SERN) was investigated with a PARC computational fluid dynamics (CFD) code, an external flow Navier-Stokes solver. The nozzle configuration was from a conceptual Mach 5 cruise aircraft powered by four air-breathing turboramjets. Initial test cases used the two-dimensional version of PARC in Euler mode to investigate the effect of geometric variation on transonic performance. Additional cases used the two-dimensional version in viscous mode and the three-dimensional version in both Euler and viscous modes. Results of the analysis indicate low nozzle performance and a highly three-dimensional nozzle flow at transonic conditions. In another comparative study using the PARC code, a single-throat SERN configuration for which experimental data were available at transonic conditions was used to validate the results of the over/under turboramjet nozzle.

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae.

PubMed

Deguchi, T; Fukuoka, A; Yasuda, M; Nakano, M; Ozeki, S; Kanematsu, E; Nishino, Y; Ishihara, S; Ban, Y; Kawada, Y

1997-03-01

We determined a partial sequence of the Klebsiella pneumoniae parC gene, including the region analogous to the quinolone resistance-determining region of the Escherichia coli gyrA gene, and examined 26 clinical strains of K. pneumoniae for an association of alterations in GyrA and ParC with susceptibilities to quinolones. The study suggests that in K. pneumoniae DNA gyrase is a primary target of quinolones and that ParC alterations play a complementary role in the development of higher-level fluoroquinolone resistance.

The Development of a Pirani Vacuum Gauge with a Platinum Wire in the J-PARC 3-GeV Rapid Cycling Synchrotron

NASA Astrophysics Data System (ADS)

Ogiwara, Norio; Hikichi, Yusuke; Yoshinari, Yoji

The back pressure of Turbo-Molecular Pumps (TMPs) is constantly monitored using Pirani gauges at J-PARC (Japan Proton Accelerator Complex) RCS (3-GeV Rapid Cycling Synchrotron) where they are used not only in rough pumping but also evacuations during beam operations. The gauge head needs to be very resistant to vibration and abrupt air inlet etc. in minimizing exposure to radiation during maintenance and hence a 50 μm in diameter W wire was adopted as the filament. This type of Pirani gauge has worked well in monitoring the back pressure of the TMP but it has become difficult to measure the low pressure of less than several Pa with the gauge, which may have been due to changes in the emissivity of the W surface. An attempt was therefore made to develop a gauge head made of Pt wire in allowing pressures as low as 0.1 Pa to be measured. Platinum is one of the best possible materials to use because it is very stable against oxidization. However, ordinary Pt gauge heads are rather weak when it comes to vibrations and abrupt air inlet due to its low tensile strength. In order to improve its toughness the filament was composed of twelve 100 μm in diameter Pt wires that were 65 mm long, resulting in it being capable of enduring a force of 25 N. All the wires were welded in series on metal poles in two separate glass plates, with the poles being electrically insulated. This resulted in the filament, 78 cm long and about 10 Ω at room temperature, being containable in a 5 cm in diameter and 10 cm long cylindrical envelope. The output from the gauge head was then examined as a function of pressure under constant current as the plan was for it to be controlled using the constant current method. Confirmation then took place that the pressures of 0.1 Pa up to 103 Pa were measurable with the gauge using current control in such way that the set value increased with pressure increases in three stages.

TRACE/PARCS analysis of the OECD/NEA Oskarshamn-2 BWR stability benchmark

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kozlowski, T.; Downar, T.; Xu, Y.

2012-07-01

On February 25, 1999, the Oskarshamn-2 NPP experienced a stability event which culminated in diverging power oscillations with a decay ratio of about 1.4. The event was successfully modeled by the TRACE/PARCS coupled code system, and further analysis of the event is described in this paper. The results show very good agreement with the plant data, capturing the entire behavior of the transient including the onset of instability, growth of the oscillations (decay ratio) and oscillation frequency. This provides confidence in the prediction of other parameters which are not available from the plant records. The event provides coupled code validationmore » for a challenging BWR stability event, which involves the accurate simulation of neutron kinetics (NK), thermal-hydraulics (TH), and TH/NK. coupling. The success of this work has demonstrated the ability of the 3-D coupled systems code TRACE/PARCS to capture the complex behavior of BWR stability events. The problem was released as an international OECD/NEA benchmark, and it is the first benchmark based on measured plant data for a stability event with a DR greater than one. Interested participants are invited to contact authors for more information. (authors)« less

Performance of the PARCS Testbed Cesium Fountain Frequency Standard

NASA Technical Reports Server (NTRS)

Enzer, Daphna G.; Klipstein, William M.

2004-01-01

A cesium fountain frequency standard has been developed as a ground testbed for the PARCS (Primary Atomic Reference Clock in Space) experiment, an experiment intended to fly on the International Space Station. We report on the performance of the fountain and describe some of the implementations motivated in large part by flight considerations, but of relevance for ground fountains. In particular, we report on a new technique for delivering cooling and trapping laser beams to the atom collection region, in which a given beam is recirculated three times effectively providing much more optical power than traditional configurations. Allan deviations down to 10 have been achieved with this method.

The roles of mutations in gyrA, parC, and ompK35 in fluoroquinolone resistance in Klebsiella pneumoniae.

PubMed

Chen, Feng-Jui; Lauderdale, Tsai-Ling; Ho, Monto; Lo, Hsiu-Jung

2003-01-01

In a survey of 541 Klebsiella pneumoniae isolates from 44 hospitals in Taiwan, three distinct populations were identified by the disk diffusion method according to the disribution of zone diameters of ciprofloxacin. Isolates with resistant, reduced-susceptible, and susceptible to fluoroquinolone were defined as CIP zone diameters of < or = 15 mm, 16-26 mm, and > or = 27 mm, respectively. Thus, in addition to 38 (7%) resistant isolates, there were 30 (5.5%) reduced-susceptible isolates and 473 (87.5%) susceptible isolates. A total of 34 isolates consisting of nine resistant, 13 reduced-susceptible, and 12 susceptible isolates were assessed for point mutations in gyrA and parC and the outer membrane profiles. The susceptibility to fluoroquinolone of 13 reduced-susceptible isolates was not altered in the presence of carbonyl cyanide m-chlorophenylhydrazone, an efflux inhibitor, showing that efflux is not a major contributor to reduced susceptibility. In addition to single mutation in gyrA, OmpK35 porin loss can also be the first step for developing fluoroquinolone resistance. No strain possesses a parC mutation without the simultaneous presence of a gyrA mutation, suggesting that mutations in parC play a complementary role for higher-level of fluoroquinolone resistance and fluoroquinolone resistance is a multistep process.

The Modeling of Advanced BWR Fuel Designs with the NRC Fuel Depletion Codes PARCS/PATHS

DOE PAGES

Ward, Andrew; Downar, Thomas J.; Xu, Y.; ...

2015-04-22

The PATHS (PARCS Advanced Thermal Hydraulic Solver) code was developed at the University of Michigan in support of U.S. Nuclear Regulatory Commission research to solve the steady-state, two-phase, thermal-hydraulic equations for a boiling water reactor (BWR) and to provide thermal-hydraulic feedback for BWR depletion calculations with the neutronics code PARCS (Purdue Advanced Reactor Core Simulator). The simplified solution methodology, including a three-equation drift flux formulation and an optimized iteration scheme, yields very fast run times in comparison to conventional thermal-hydraulic systems codes used in the industry, while still retaining sufficient accuracy for applications such as BWR depletion calculations. Lastly, themore » capability to model advanced BWR fuel designs with part-length fuel rods and heterogeneous axial channel flow geometry has been implemented in PATHS, and the code has been validated against previously benchmarked advanced core simulators as well as BWR plant and experimental data. We describe the modifications to the codes and the results of the validation in this paper.« less

PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blankenship, Robert E.

"PARC - Scientific Exchange Program" was submitted by the Photosynthetic Antenna Research Center (PARC) to the "Life at the Frontiers of Energy Research" video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) inmore » 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.« less

PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Blankenship, Robert E. (Director, Photosynthetic Antenna Research Center); PARC Staff

2017-12-09

'PARC - Scientific Exchange Program' was submitted by the Photosynthetic Antenna Research Center (PARC) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

In Vitro Activity of Five Quinolones and Analysis of the Quinolone Resistance-Determining Regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum Clinical Isolates from Perinatal Patients in Japan

PubMed Central

Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto

2015-01-01

Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L–GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan. PMID:25645833

In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

PubMed

Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto; Yanagihara, Itaru

2015-04-01

Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L-GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Approches pour la reduction de l'impact de defaut dans le transport d'energie du parc eolien offshore via VSC-HVDC =

NASA Astrophysics Data System (ADS)

Benadja, Mounir

Dans ce travail est presente un systeme de generation d'energie d'un parc eolien offshore et un systeme de transport utilisant les stations VSC-HVDC connectees au reseau principal AC onshore. Trois configurations ont ete etudiees, modelisees et validees par simulation. Dans chacune des configurations, des contributions ameliorant les cotes techniques et economiques sont decrites ci-dessous : La premiere contribution concerne un nouvel algorithme MPPT (Maximum Power Point Tracking) utilise pour l'extraction de la puissance maximale disponible dans les eoliennes des parcs offshores. Cette technique d'extraction du MPPT ameliore le rendement energetique de la chaine de conversion des energies renouvelables notamment l'energie eolienne a petite et a grande echelles (parc eolien offshore) qui constitue un probleme pour les constructeurs qui se trouvent confrontes a developper des dispositifs MPPT simples, moins couteux, robustes, fiables et capable d'obtenir un rendement energetique maximal. La deuxieme contribution concerne la reduction de la taille, du cout et de l'impact des defauts electriques (AC et DC) dans le systeme construit pour transporter l'energie d'un parc eolien offshore (OWF) vers le reseau principal AC onshore via deux stations 3L-NPC VSCHVDC. La solution developpee utilise des observateurs non-lineaires bases sur le filtre de Kalman etendu (EKF). Ce filtre permet d'estimer la vitesse de rotation et la position du rotor de chacune des generatrices du parc eolien offshore et de la tension du bus DC de l'onduleur DC-AC offshore et des deux stations 3L-NPC-VSC-HVDC (offshore et onshore). De plus, ce developpement du filtre de Kalman etendu a permis de reduire l'impact des defauts AC et DC. Deux commandes ont ete utilisees, l'une (commande indirect dans le plan abc) avec EKF integre destinee pour controler le convertisseur DC-AC offshore et l'autre (commande d-q) avec EKF integre pour controler les convertisseurs des deux stations AC-DC et DC-AC tout en

Wintertime component of the THORPEX Pacific-Asian Regional Campaign (T-PARC)

NASA Astrophysics Data System (ADS)

Song, Y.; Toth, Z.; Asuma, Y.; Reynolds, C.; Lngland, R.; Szunyogh, I.; Colle, B.; Chang, E.; Doyle, C.; Kats, A.

2009-04-01

The winter component of the T-PARC is an international field project that aims at improving high impact weather event forecasts for North America. The main objective is to understand how perturbations from the tropics, Eurasia and polar fronts travel through waveguide and turn into high impact weather events. Through adaptive observations by using manned aircrafts (NOAA G-IV and US Air force C-130s) and Russian rawinsonde network over data sparse regions, it is expected that accurate initial conditions will improve the numerical weather forecasts. Non-adaptive aircraft measurements over the Pacific Rim and part of India are also deployed through E-AMDAR program, which is expected to improve the background field over Asia where perturbations are initiated. The campaign is led by NOAA and joined by agencies and universities from US, Canada, Mexico, Japan, ECWMF, and Russia. While most observational data will be assimilated by operational centers to improve real time numerical weather predictions, post field studies will focus on aspects such as: data impact on forecast and analysis, dry and moist processes that affect the formation and propagation of perturbations, meso-scale storm structure, error growth, forecast "busts" under certain atmospheric regimes, and socio-economic applications such as costs and benefits of improved forecasts and their use by the public for high impact weather events. In particular, a Winter Olympics demonstration project (February 12 - February 28) is expected to be a test bed during winter T-PARC for real user outreach and application purposes. Effectiveness of existing targeting methods as well as new targeting methods in the 3-5 day lead time range will be pursued and other aspects related to data assimilation and numerical forecasts (both deterministic and ensemble forecasts) will be investigated within this project as well.

Raman lidars for a better understanding of pollution in the Arctic System (PARCS)

NASA Astrophysics Data System (ADS)

Patrick, Chazette; Jean-Christophe, Raut; Julien, Totems; Xiaoxia, Shang; Christophe, Caudoux; Julien, Delanoë; Kathy, Law

2018-04-01

The development of oil and gas drilling and the opening of new shipping routes, in the Barents and Norway seas, poses new challenges for the Arctic environment due to the impact of air pollution emissions on climate and air quality. To improve our knowledge of the interactions between aerosols, water vapor and cloud cover, within the French PARCS (Pollution in the ARCtic System) project, Raman lidar observations were performed from the ground and from an ultra-light aircraft near the North Cape in northern Norway, and coupled with measurements from a 95 GHz ground-based Doppler radar.

Satellite-Derived Tropical Cyclone Intensities And Structure Change (TCS-08)

DTIC Science & Technology

2009-09-30

eyewall details are available from the NRL P-3 Eldora radar and from the CloudSat cloud radar that infrequently samples TC inner core structure...18. Black, P., and J. Hawkins, 2009: Overview of the WC-130J storm-scale observations during T- PARC /TCS-08, Third THORPEX International Science...satellite data and products for mission support and science applications in T- PARC , Third THORPEX International Science Symposium, Monterey, CA

[Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis].

PubMed

Gushchin, A E; Ladygina, V G; Govorun, V M; Taraskina, A M; Savicheva, A M

2000-01-01

Fifteen strains of M. hominis isolated from patients with urogenital inflammations were analyzed. Variations in the quinolone resistance-determining regions (QRDR) have been found in fluoroquinolone-resistant M. hominis clinical isolates in comparison with the reference PG21 strain. In one isolate, parC had Asn substitute at position 91.

Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.

PubMed

Al-Marzooq, Farah; Mohd Yusof, Mohd Yasim; Tay, Sun Tee

2014-01-01

Ninety-three Malaysian extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were investigated for ciprofloxacin resistance. Two mismatch amplification mutation (MAMA) assays were developed and used to facilitate rapid detection of gyrA and parC mutations. The isolates were also screened for plasmid-mediated quinolone resistance (PMQR) genes including aac(6')-Ib-cr, qepA, and qnr. Ciprofloxacin resistance (MICs 4- ≥ 32  μ g/mL) was noted in 34 (37%) isolates, of which 33 isolates had multiple mutations either in gyrA alone (n = 1) or in both gyrA and parC regions (n = 32). aac(6')-Ib-cr was the most common PMQR gene detected in this study (n = 61), followed by qnrB and qnrS (n = 55 and 1, resp.). Low-level ciprofloxacin resistance (MICs 1-2  μ g/mL) was noted in 40 (43%) isolates carrying qnrB accompanied by either aac(6')-Ib-cr (n = 34) or a single gyrA 83 mutation (n = 6). Ciprofloxacin resistance was significantly associated with the presence of multiple mutations in gyrA and parC regions. While the isolates harbouring gyrA and/or parC alteration were distributed into 11 PFGE clusters, no specific clusters were associated with isolates carrying PMQR genes. The high prevalence of ciprofloxacin resistance amongst the Malaysian ESBL-producing K. pneumoniae isolates suggests the need for more effective infection control measures to limit the spread of these resistant organisms in the hospital.

Human rights assessment in Parc Jean Marie Vincent, Port-au-Prince, Haiti.

PubMed

Cullen, Kimberly A; Ivers, Louise C

2010-12-15

Months after a 7.0 magnitude earthquake hit Port-au-Prince, Haiti, over one million remain homeless and living in spontaneous internally displaced person (IDP) camps. Billions of dollars from aid organizations and government agencies have been pledged toward the relief effort, yet many basic human needs, including food, shelter, and sanitation, continue to be unmet. The Sphere Project, "Humanitarian Charter and Minimum Standards in Disaster Response," identifies the minimum standards to be attained in disaster response. From a human rights perspective and utilizing key indicators from the Sphere Project as benchmarks, this article reports on an assessment of the living conditions approximately 12 weeks after the earthquake in Parc Jean Marie Vincent, a spontaneous IDP camp in Port-au-Prince. A stratified random sample of households in the camp, proportionate to the number of families living in each sector, was selected. Interview questions were designed to serve as "key indicators" for the Sphere Project minimum standards. A total of 486 interviews were completed, representing approximately 5% of households in each of the five sectors of the camp. Our assessment identified the relative achievements and shortcomings in the provision of relief services in Parc Jean Marie Vincent. At the time of this survey, the Sphere Project minimum standards for access to health care and quantity of water per person per day were being met. Food, shelter, sanitation, and security were below minimum accepted standard and of major concern. The formal assessment reported here was completed by September 2010, and is necessarily limited to conditions in Haiti before the cholera outbreak in October. Copyright © 2010 Cullen and Ivers. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any

Molecular Analysis of Ciprofloxacin Resistance Mechanisms in Malaysian ESBL-Producing Klebsiella pneumoniae Isolates and Development of Mismatch Amplification Mutation Assays (MAMA) for Rapid Detection of gyrA and parC Mutations

PubMed Central

Mohd Yusof, Mohd Yasim; Tay, Sun Tee

2014-01-01

Ninety-three Malaysian extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were investigated for ciprofloxacin resistance. Two mismatch amplification mutation (MAMA) assays were developed and used to facilitate rapid detection of gyrA and parC mutations. The isolates were also screened for plasmid-mediated quinolone resistance (PMQR) genes including aac(6′)-Ib-cr, qepA, and qnr. Ciprofloxacin resistance (MICs 4– ≥ 32 μg/mL) was noted in 34 (37%) isolates, of which 33 isolates had multiple mutations either in gyrA alone (n = 1) or in both gyrA and parC regions (n = 32). aac(6′)-Ib-cr was the most common PMQR gene detected in this study (n = 61), followed by qnrB and qnrS (n = 55 and 1, resp.). Low-level ciprofloxacin resistance (MICs 1-2 μg/mL) was noted in 40 (43%) isolates carrying qnrB accompanied by either aac(6′)-Ib-cr (n = 34) or a single gyrA 83 mutation (n = 6). Ciprofloxacin resistance was significantly associated with the presence of multiple mutations in gyrA and parC regions. While the isolates harbouring gyrA and/or parC alteration were distributed into 11 PFGE clusters, no specific clusters were associated with isolates carrying PMQR genes. The high prevalence of ciprofloxacin resistance amongst the Malaysian ESBL-producing K. pneumoniae isolates suggests the need for more effective infection control measures to limit the spread of these resistant organisms in the hospital. PMID:24860827

Surface production dominating Cs-free H- ion source for high intensity and high energy proton accelerators

NASA Astrophysics Data System (ADS)

Ueno, Akira; Ikegami, Kiyoshi; Kondo, Yasuhiro

2004-05-01

A Cs-free negative hydrogen (H-) ion source driven by pulsed arc plasma with a LaB6 filament is being operated for the beam tests of the Japan Proton Accelerator Research Complex (J-PARC) linac. A peak H- current of 38 mA, which exceeds the requirement of the J-PARC first stage, is stably extracted from the ion source with a beam duty factor of 0.9% (360 μs×25 Hz) by principally optimizing the surface condition and shape of the plasma electrode. The sufficiently small emittance of the beam was confirmed by high transmission efficiency (around 90%) through the following 324 MHz 3 MeV J-PARC radio frequency quadrupole linac (M. Ikegami et al., Proc. 2003 Part. Accel. Conf. 2003, p. 1509). The process of the optimization, which confirms the validity of hypothesis that H- ions are produced by surface reaction on a Mo plasma electrode dominantly in the ion source, is presented.

Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study.

PubMed

De Castro-Orós, Isabel; Irún, Pilar; Cebolla, Jorge Javier; Rodriguez-Sureda, Victor; Mallén, Miguel; Pueyo, María Jesús; Mozas, Pilar; Dominguez, Carmen; Pocoví, Miguel

2017-02-21

Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C. In a prospective observational cohort study, incorporating a retrospective determination of NP-C SI scores, two different diagnostic approaches were applied in two separate groups of unrelated patients from 51 Spanish medical centers (n = 118 in both groups). From Jan 2010 to Apr 2012 (Period 1), patients with ≥2 clinical signs/symptoms of NP-C were considered 'suspected NP-C' cases, and NPC1/NPC2 sequencing, plasma chitotriosidase (ChT), CCL18/PARC and sphingomyelinase levels were assessed. Based on findings in Period 1, plasma ChT and CCL18/PARC, and NP-C SI prediction scores were determined in a second group of patients between May 2012 and Apr 2014 (Period 2), and NPC1 and NPC2 were sequenced only in those with elevated ChT and/or elevated CCL18/PARC and/or NP-C SI ≥70. Filipin staining and 7-ketocholesterol (7-KC) measurements were performed in all patients with NP-C gene mutations, where possible. In total across Periods 1 and 2, 10/236 (4%) patients had a confirmed diagnosis o NP-C based on gene sequencing (5/118 [4.2%] in each Period): all of these patients had two causal NPC1 mutations. Single mutant NPC1 alleles were detected in 8/236 (3%) patients, overall. Positive filipin staining results comprised three classical and five variant biochemical phenotypes. No NPC2 mutations were detected. All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or NP-C SI scores ≥70. Plasma 7

TRACE/PARCS Analysis of ATWS with Instability for a MELLLA+BWR/5

DOE PAGES

L. Y. Cheng; Baek, J. S.; Cuadra, A.; ...

2016-06-06

A TRACE/PARCS model has been developed to analyze anticipated transient without SCRAM (ATWS) events for a boiling water reactor (BWR) operating in the maximum extended load line limit analysis-plus (MELLLA+) expanded operating domain. The MELLLA+ domain expands allowable operation in the power/flow map of a BWR to low flow rates at high power conditions. Such operation exacerbates the likelihood of large amplitude power/flow oscillations during certain ATWS scenarios. The analysis shows that large amplitude power/flow oscillations, both core-wide and out-of-phase, arise following the establishment of natural circulation flow in the reactor pressure vessel (RPV) after the trip of the recirculationmore » pumps and an increase in core inlet subcooling. The analysis also indicates a mechanism by which the fuel may experience heat-up that could result in localized fuel damage. TRACE predicts the heat-up to occur when the cladding surface temperature exceeds the minimum stable film boiling temperature after periodic cycles of dryout and rewet; and the fuel becomes “locked” into a film boiling regime. Further, the analysis demonstrates the effectiveness of the simulated manual operator actions to suppress the instability.« less

Determination of gyrA and parC mutations and prevalence of plasmid-mediated quinolone resistance genes in Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infection in Iran.

PubMed

Mirzaii, Mehdi; Jamshidi, Sanaz; Zamanzadeh, Maryam; Marashifard, Masoud; Malek Hosseini, Seyed Ali Asghar; Haeili, Mehri; Jahanbin, Fariba; Mansouri, Fariba; Darban-Sarokhalil, Davood; Khoramrooz, Seyed Sajjad

2018-06-01

Fluoroquinolones (FQs) are recommended as the drugs of choice for the empirical treatment of urinary tract infections (UTIs). This study investigated the molecular determinants of FQ resistance in Escherichia coli and Klebsiella pneumoniae isolates in Iran. A total of 364 clinical isolates of E. coli (n=144) and K. pneumoniae (n=220) were collected from patients with UTI. Susceptibility of the isolates to ciprofloxacin, levofloxacin, gatifloxacin and nalidixic acid was evaluated by disk diffusion. The presence of qnrA, qnrB and qnrS genes was assessed by PCR. Nucleotide sequences of the gyrA and parC genes were determined. Eighty-seven (60.4%) and 15 (6.8%) E. coli and K. pneumoniae isolates, respectively, were resistant to at least one of the tested FQs. Plasmid-mediated quinolone resistance (PMQR) genes were detected in 12.6% and 60.0% of FQ-resistant E. coli and K. pneumoniae, respectively. Whilst qnrB predominated in K. pneumoniae, qnrS was the most prevalent PMQR gene in E. coli. S83L (98.9%) and D87N (59.8%) were the most frequent mutations identified in GyrA of E. coli, and 55.2% (n=48) of FQ-resistant E. coli isolates had mutation in ParC harbouring S80I and E84V substitutions. The GyrAS83L substitution was found in only one FQ-resistant K. pneumoniae isolate. FQ resistance was much more common in E. coli isolates than in K. pneumoniae. Whilst mutations in the drug target-encoding genes gyrA and parC were the major mechanisms involved in FQ resistance in E. coli, PMQR determinants commonly mediated FQ resistance in K. pneumoniae. Copyright © 2018. Published by Elsevier Ltd.

Physics prospects of future neutrino oscillation experiments in Asia

NASA Astrophysics Data System (ADS)

Hagiwara, Kaoru

2004-12-01

The three neutrino model has 9 physical parameters, 3 neutrino masses, 3 mixing angles and 3 CP violating phases. Among them, neutrino oscillation experiments can probe 6 neutrino parameters: 2 mass squared differences, 3 mixing angles, and 1 CP phase. The experiments performed so far determined the magnitudes of the two mass squared differences, the sign of the smaller mass squared difference, the magnitudes of two of the three mixing angles, and the upper bound on the third mixing angle. The sign of the larger mass squared difference (the neutrino mass hierarchy pattern), the magnitude of the third mixing angle and the CP violating phase, and a two-fold ambiguity in the mixing angle that dictates the atmospheric neutrino oscillation should be determined by future oscillation experiments. In this talk, I introduce a few ideas of future long baseline neutrino oscillation experiments which make use of the super neutrino beams from J-PARC (Japan Proton Accelerator Research Complex) in Tokai village. We examine the potential of HyperKamiokande (HK), the proposed 1 Mega-ton water Čerenkov detector, and then study the fate and possible detection of the off-axis beam from J-PARC in Korea, which is available free throughout the period of the T2K (Tokai-to-SuperKamiokande) and the possible T-to-HK projects. Although the CP violating phase can be measured accurately by studying ν→ν and ν→ν oscillations at HK, there appear multiple solution ambiguities which can be solved only by determining the neutrino mass hierarchy and the twofold ambiguity in the mixing angle. We show that very long baseline experiments with higher energy beams from J-PARC and a possible huge Water Čerenkov Calorimeter detector proposed in Beijing can resolve the neutrino mass hierarchy. If such a detector can be built in China, future experiments with a muon storage ring neutrino factory at J-PARC will be able to lift all the degeneracies in the three neutrino model parameters.

Beam dynamics design of the muon linac high-beta section

NASA Astrophysics Data System (ADS)

Kondo, Y.; Hasegawa, K.; Otani, M.; Mibe, T.; Yoshida, M.; Kitamura, R.

2017-07-01

A muon linac development for a new muon g-2 experiment is now going on at J-PARC. Muons from the muon beam line (H line) at the J-PARC muon science facility are once stopped in a silica-aerogel target, and room temperature muoniums are evaporated from the aerogel. They are dissociated with lasers, then accelerated up to 212 MeV using a linear accelerator. For the accelerating structure from 40 MeV, disk-loaded traveling-wave structure is applicable because the particle beta is more than 0.7. The structure itself is similar to that for electron linacs, however, the cell length should be harmonic to the increase of the particle velocity. In this paper, the beam dynamics design of this muon linac using the disk-loaded structure (DLS) is described.

Principal Assistant Responsible for Contracting (PARC) - J8 - The National

Science.gov Websites

Officer of the ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PubMed

Brisse, S; Milatovic, D; Fluit, A C; Verhoef, J; Martin, N; Scheuring, S; Köhrer, K; Schmitz, F J

1999-08-01

The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes. Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes.

Comparative In Vitro Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes Clinical Isolates with Alterations in GyrA and ParC Proteins

PubMed Central

Brisse, Sylvain; Milatovic, Dana; Fluit, Ad C.; Verhoef, Jan; Martin, Nele; Scheuring, Sybille; Köhrer, Karl; Schmitz, Franz-Josef

1999-01-01

The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes. Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes. PMID:10428935

J domain independent functions of J proteins.

PubMed

Ajit Tamadaddi, Chetana; Sahi, Chandan

2016-07-01

Heat shock proteins of 40 kDa (Hsp40s), also called J proteins, are obligate partners of Hsp70s. Via their highly conserved and functionally critical J domain, J proteins interact and modulate the activity of their Hsp70 partners. Mutations in the critical residues in the J domain often result in the null phenotype for the J protein in question. However, as more J proteins have been characterized, it is becoming increasingly clear that a significant number of J proteins do not "completely" rely on their J domains to carry out their cellular functions, as previously thought. In some cases, regions outside the highly conserved J domain have become more important making the J domain dispensable for some, if not for all functions of a J protein. This has profound effects on the evolution of such J proteins. Here we present selected examples of J proteins that perform J domain independent functions and discuss this in the context of evolution of J proteins with dispensable J domains and J-like proteins in eukaryotes.

Indicators, Predictors, and Determinants of Conflict Escalation and De-escalation. A Review of the Psychological Literature

DTIC Science & Technology

2009-05-01

des outils habituels de la psychologie parce que ces gens ne sont pratiquement jamais disponibles pour les chercheurs. Pour compenser, des méthodes...Ballard, E. J. (1983). Canadian prime ministers: Complexity in political crises. Canadian Psychology/ Psychologie Canadienne, 24, 125-129. Beasley

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, K. A.; Schoefer, V.; Tomizawa, M.

The new accelerator complex at J-PARC will operate with both high energy and very high intensity proton beams. With a design slow extraction efficiency of greater than 99% this facility will still be depositing significant beam power onto accelerator components [2]. To achieve even higher efficiencies requires some new ideas. The design of the extraction system and the accelerator lattice structure leaves little room for improvement using conventional techniques. In this report we will present one method for improving the slow extraction efficiency at J-PARC by adding duodecapoles or octupoles to the slow extraction system. We will review the theorymore » of resonant extraction, describe simulation methods, and present the results of detailed simulations. From our investigations we find that we can improve extraction efficiency and thereby reduce the level of residual activation in the accelerator components and surrounding shielding.« less

First 2 years of Atmospheric CO2 measurements in the Estany Llong plain (2100 masl, Parc Nacional d'Aigüestortes i Estany de Sant Maurici, Pyrenees, Catalonia, Spain).

NASA Astrophysics Data System (ADS)

Curcoll, Roger; Recolons, Montserrat; Font, Anna; Agraz, Laura; Parga, Elena; Bacardit, Montse; Camarero, Lluís.; Pueyo, Salva; Rodó, Xavier; Morguí, Josep Anton

2010-05-01

Since April 2009, air samples are being taken bi-weekly at 10 GMT in the plain of the Estany Llong at 2100 masl. Estany Llong air sampling site (ELL, 42°34'29''N 0°57'17''E) is a remote site situated in the SW principal valley of the Parc Nacional d'Aigüestortes i Estany de Sant Maurici. New Flask-sampling equipment for Remote Mountain Sites was developed by the Institut Català de Ciències del Clima (IC3) to allow flask sampling in extreme weather conditions and carrying the sampling equipment for more than 10 km without damaging flasks. Dry Air analysis for CO2 are done at the Laboratory of IC3 using two coupled modified IRGA Licor-7000, where both pressure and flow are externally controlled. Far away from populated areas, ELL site acts as a remote site, but it is also responding to discrete events as snow melting, summer cattle breeding on pastures and trekking frequentation. Series of CO2 obtained are included as part of Long Term Ecological Research (LTER) at the Parc Nacional d'Aigüestortes i Estany de Sant Maurici. In the long term, these measurements show the mountain ecosystems contribution and geomorphologic influence on the CO2 budget of the air masses crossing a mountain range.

Are low altitude alpine tundra ecosystems under threat? A case study from the Parc National de la Gaspésie, Québec

NASA Astrophysics Data System (ADS)

Dumais, Catherine; Ropars, Pascale; Denis, Marie-Pier; Dufour-Tremblay, Geneviève; Boudreau, Stéphane

2014-09-01

According to the 2007 IPCC report, the alpine tundra ecosystems found on low mountains of the northern hemisphere are amongst the most threatened by climate change. A treeline advance or a significant erect shrub expansion could result in increased competition for the arctic-alpine species usually found on mountaintops and eventually lead to their local extinction. The objectives of our study were to identify recent changes in the cover and growth of erect woody vegetation in the alpine tundra of Mont de la Passe, in the Parc National de la Gaspésie (Québec, Canada). The comparison of two orthorectified aerial photos revealed no significant shift of the treeline between 1975 and 2004. During the same period however, shrub species cover increased from 20.2% to 30.4% in the lower alpine zone. Dendrochronological analyses conducted on Betula glandulosa Michx. sampled at three different positions along an altitudinal gradient (low, intermediate and high alpine zone) revealed that the climatic determinants of B. glandulosa radial growth become more complex with increasing altitude. In the lower alpine zone, B. glandulosa radial growth is only significantly associated positively to July temperature. In the intermediate alpine zone, radial growth is associated positively to July temperature but negatively to March temperature. In the high alpine zone, radial growth is positively associated to January, July and August temperature but negatively to March temperature. The positive association between summer temperatures and radial growth suggests that B. glandulosa could potentially benefit from warmer temperatures, a phenomenon that could lead to an increase in its cover over the next few decades. Although alpine tundra vegetation is not threatened in the short-term in the Parc National de la Gaspésie, erect shrub cover, especially B. glandulosa, could likely increase in the near future, threatening the local arctic-alpine flora.

Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins.

PubMed Central

Deguchi, T; Yasuda, M; KawamuraT; Nakano, M; Ozeki, S; Kanematsu, E; Nishino, Y; Kawada, Y

1997-01-01

MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneumoniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater activity than currently available fluoroquinolones. PMID:9371364

Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins.

PubMed

Deguchi, T; Yasuda, M; KawamuraT; Nakano, M; Ozeki, S; Kanematsu, E; Nishino, Y; Kawada, Y

1997-11-01

MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneumoniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater activity than currently available fluoroquinolones.

Satellite-Derived Tropical Cyclone Intensities and Structure Change (TCS-08 and ITOP)

DTIC Science & Technology

2010-09-30

Radar and Aircraft Instrumentation (SAMURAI) created by Michael Bell (2010) of the Naval Postgraduate School that places an emphasis on customization...Force weather officers, crew and the operations centers to gather the optimum set of recon data (dropsondes, AXBTs, flight level, SFMR, and radar ...CA, Sept. 14-18. Black, P., and J. Hawkins, 2009: Overview of the WC-130J storm-scale observations during T- PARC /TCS-08, Third THORPEX

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-16-0011, J-16-0012, J-16-0013, J-16-0014, J-16-0015, and J-16-0016

EPA Pesticide Factsheets

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-16-0011, J-16-0012, J-16-0013, J-16-0014, J-16-0015, and J-16-0016, a biofuel producing organism.

Improvements of vacuum system in J-PARC 3 GeV synchrotron

NASA Astrophysics Data System (ADS)

Kamiya, J.; Hikichi, Y.; Namekawa, Y.; Takeishi, K.; Yanagibashi, T.; Kinsho, M.; Yamamoto, K.; Sato, A.

2017-07-01

The RCS vacuum system has been upgraded since the completion of its construction towards the objectives of both better vacuum quality and higher reliability of the components. For the better vacuum quality, (1) pressure of the injection beam line was improved to prevent the H-beam from converting to H0; (2) leakage in the beam injection area due to the thermal expansion was eliminated by applying the adequate torque amount for the clamps; (3) new in-situ degassing method of the kicker magnet was developed. For the reliability increase of the components, (1) A considerable number of fluoroelastmer seal was exchanged to metal seal with the low spring constant bellows and the light clamps; (2) TMP controller for the long cable was developed to prevent the controller failure by the severe electrical noise; (3) A number of TMP were installed instead of ion pumps in the RF cavity section as an insurance for the case of pump trouble.

The Hippoboscidae (Insecta: Diptera) from Madagascar, with new records from the “Parc National de Midongy Befotaka”

PubMed Central

Rahola, N.; Goodman, S.M.; Robert, V.

2011-01-01

The Hippoboscidae or “louse-flies” is a family of pupiparous Diptera, which in their adult stage are ectoparasites of mammals and birds. This paper presents a comprehensive review of Malagasy Hippoboscidae. In total, amongst the 213 species of this family known worldwide, 14 have been reported in Madagascar, among which six are considered as endemic to the Malagasy region. In addition, data are presented from a collection of 17 Hippoboscidae obtained from seven species of forest-dwelling birds in the “Parc National de Midongy Befotaka”, southeastern Madagascar, in 2003. The flies in this collection belong to three different species: Icosta malagasii (one), Ornithoica podicipis (ten) and Ornithoctona laticornis (six). The two former species were previously only known from single specimens in museum collections; the later species is distributed across much of the Afrotropical region and the records presented herein are the first for Madagascar. All the seven bird species are new hosts for hippoboscids. We present the first description of the male of Icosta malagasii. An illustrated dichotomous determination key of the 14 Malagasy species, based on morphological criteria only, is presented. PMID:21678788

T0 chopper developed at KEK

NASA Astrophysics Data System (ADS)

Itoh, Shinichi; Ueno, Kenji; Ohkubo, Ryuji; Sagehashi, Hidenori; Funahashi, Yoshisato; Yokoo, Tetsuya

2012-01-01

We developed a T0 chopper rotating at 100 Hz at the High Energy Accelerator Research Organization (KEK) for the reduction of background noise in neutron scattering experiments at the Japan Proton Accelerator Research Complex (J-PARC). The T0 chopper consists of a rotor of 120 kg made from Inconel X750, supported by mechanical bearings in vacuum. The motor is located outside the vacuum and the rotation is transmitted into vacuum through magnetic seals. The motor should rotate in synchronization with the production timing of pulsed neutrons. The rotational fluctuations and running time were in good agreement with the specifications, i.e., phase control accuracy of less than 5 μs and running time of more than 4000 h without changing any component. A semi-auto installation mechanism was developed for installing under the shielding and for maintenance purposes. Based on the result of the development, actual machines were made for the neutron beamlines at J-PARC. We successfully reduced the background noise to 1/30 at neutron energies near 500 meV.

Measuring the leading hadronic contribution to the muon g-2 via the -e elastic scattering.

NASA Astrophysics Data System (ADS)

Marconi, Umberto; Piccinini, Fulvio

2018-05-01

The precision measurement of the anomalous magnetic moment g-2 of the muon presently exhibits a 3.5 σ deviation between theory and experiments. In the next few years the anomalous magnetic moment will be measured to higher precisions at Fermilab and J-PARC. The theoretical prediction can be improved by reducing the uncertainty on the leading hadronic correction HLO μ to the g-2. Here we present a novel approach to determine aHLO μ with space-like data, by means of precise measurement of the hadronic shift of the effective electromagnetic coupling α exploiting the elastic scattering of 150 GeV muons (currently available at CERN North area) on atomic electrons of a low-Z target. The direct measurement of aHLO μ in the space-like region will provide a new independent determination competitive with the time-like dispersive approach, and will consolidate the theoretical prediction of the muon g-2 in the Standard Model. It will allow therefore a firmer interpretation of the measurements of the future muon g-2 experiments at Fermilab and J-PARC

Material issues relating to high power spallation neutron sources

NASA Astrophysics Data System (ADS)

Futakawa, M.

2015-02-01

Innovative researches using neutrons are being performed at the Materials and Life Science Experimental Facility (MLF) at the Japan Proton Accelerator Research Complex (J-PARC), in which a mercury target system is installed for MW-class pulse spallation neutron sources. In order to produce neutrons by the spallation reaction, proton beams are injected into the mercury target. At the moment, when the intense proton beam hits the target, pressure waves are generated in mercury because of the abrupt heat deposition. The pressure waves interact with the target vessel, leading to negative pressure that may cause cavitation along the vessel wall, i.e. on the interface between liquid and solid metals. On the other hand, the structural materials are subjected to irradiation damage due to protons and neutrons, very high cycle fatigue damages and so-called "liquid metal embrittlement". That is, the structural materials must be said to be exposed to the extremely severe environments. In the paper, research and development relating to the material issues in the high power spallation neutron sources that has been performed so far at J-PARC is summarized.

cyNeo4j: connecting Neo4j and Cytoscape

PubMed Central

Summer, Georg; Kelder, Thomas; Ono, Keiichiro; Radonjic, Marijana; Heymans, Stephane; Demchak, Barry

2015-01-01

Summary: We developed cyNeo4j, a Cytoscape App to link Cytoscape and Neo4j databases to utilize the performance and storage capacities Neo4j offers. We implemented a Neo4j NetworkAnalyzer, ForceAtlas2 layout and Cypher component to demonstrate the possibilities a distributed setup of Cytoscape and Neo4j have. Availability and implementation: The app is available from the Cytoscape App Store at http://apps.cytoscape.org/apps/cyneo4j, the Neo4j plugins at www.github.com/gsummer/cyneo4j-parent and the community and commercial editions of Neo4j can be found at http://www.neo4j.com. Contact: georg.summer@gmail.com PMID:26272981

The solar gravitational figure: J2 and J4

NASA Technical Reports Server (NTRS)

Ulrich, R. K.; Hawkins, G. W.

1980-01-01

The theory of the solar gravitational figure is derived including the effects of differential rotation. It is shown that J sub 4 is smaller than J sub 2 by a factor of about 10 rather than being of order J sub 2 squared as would be expected for rigid rotation. The dependence of both J sub 2 and J sub 4 on envelope mass is given. High order p-mode oscillation frequencies provide a constraint on solar structure which limits the range in envelope mass to the range 0.01 M sub E/solar mass 0.04. For an assumed rotation law in which the surface pattern of differential rotation extends uniformly throughout the convective envelope, this structural constraint limits the ranges of J sub 2 and J sub 4 in units of 10 to the -8th power to 10 J sub 2 15 and 0.6 -J sub 4 1.5. Deviations from these ranges would imply that the rotation law is not constant with depth and would provide a measure of this rotation law.

KC-130J Transport Aircraft (KC-130J)

DTIC Science & Technology

2015-12-01

Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-433 KC-130J Transport Aircraft (KC-130J) As of FY 2017 President’s Budget Defense Acquisition...Management Information Retrieval (DAMIR) March 23, 2016 15:23:28 UNCLASSIFIED KC-130J December 2015 SAR March 23, 2016 15:23:28 UNCLASSIFIED 2...Document OSD - Office of the Secretary of Defense O&S - Operating and Support PAUC - Program Acquisition Unit Cost KC-130J December 2015 SAR March 23

Observation of ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ.

PubMed

Ablikim, M; Achasov, M N; Ai, X C; Albayrak, O; Albrecht, M; Ambrose, D J; Amoroso, A; An, F F; An, Q; Bai, J Z; Baldini Ferroli, R; Ban, Y; Bennett, D W; Bennett, J V; Bertani, M; Bettoni, D; Bian, J M; Bianchi, F; Boger, E; Boyko, I; Briere, R A; Cai, H; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, H Y; Chen, J C; Chen, M L; Chen, S; Chen, S J; Chen, X; Chen, X R; Chen, Y B; Cheng, H P; Chu, X K; Cibinetto, G; Dai, H L; Dai, J P; Dbeyssi, A; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; De Mori, F; Ding, Y; Dong, C; Dong, J; Dong, L Y; Dong, M Y; Dou, Z L; Du, S X; Duan, P F; Fan, J Z; Fang, J; Fang, S S; Fang, X; Fang, Y; Farinelli, R; Fava, L; Fedorov, O; Feldbauer, F; Felici, G; Feng, C Q; Fioravanti, E; Fritsch, M; Fu, C D; Gao, Q; Gao, X L; Gao, X Y; Gao, Y; Gao, Z; Garzia, I; Goetzen, K; Gong, L; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, R P; Guo, Y; Guo, Y P; Haddadi, Z; Hafner, A; Han, S; Hao, X Q; Harris, F A; He, K L; Held, T; Heng, Y K; Hou, Z L; Hu, C; Hu, H M; Hu, J F; Hu, T; Hu, Y; Huang, G S; Huang, J S; Huang, X T; Huang, X Z; Huang, Y; Huang, Z L; Hussain, T; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L W; Jiang, X S; Jiang, X Y; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Johansson, T; Julin, A; Kalantar-Nayestanaki, N; Kang, X L; Kang, X S; Kavatsyuk, M; Ke, B C; Kiese, P; Kliemt, R; Kloss, B; Kolcu, O B; Kopf, B; Kornicer, M; Kupsc, A; Kühn, W; Lange, J S; Lara, M; Larin, P; Leng, C; Li, C; Li, Cheng; Li, D M; Li, F; Li, F Y; Li, G; Li, H B; Li, H J; Li, J C; Li, Jin; Li, K; Li, K; Li, Lei; Li, P R; Li, Q Y; Li, T; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Y B; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Lin, D X; Liu, B; Liu, B J; Liu, C X; Liu, D; Liu, F H; Liu, Fang; Liu, Feng; Liu, H B; Liu, H H; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, J Y; Liu, K; Liu, K Y; Liu, L D; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Z A; Liu, Zhiqing; Loehner, H; Lou, X C; Lu, H J; Lu, J G; Lu, Y; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lyu, X R; Ma, F C; Ma, H L; Ma, L L; Ma, M M; Ma, Q M; Ma, T; Ma, X N; Ma, X Y; Ma, Y M; Maas, F E; Maggiora, M; Mao, Y J; Mao, Z P; Marcello, S; Messchendorp, J G; Min, J; Mitchell, R E; Mo, X H; Mo, Y J; Morales Morales, C; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nerling, F; Nikolaev, I B; Ning, Z; Nisar, S; Niu, S L; Niu, X Y; Olsen, S L; Ouyang, Q; Pacetti, S; Pan, Y; Patteri, P; Pelizaeus, M; Peng, H P; Peters, K; Pettersson, J; Ping, J L; Ping, R G; Poling, R; Prasad, V; Qi, H R; Qi, M; Qian, S; Qiao, C F; Qin, L Q; Qin, N; Qin, X S; Qin, Z H; Qiu, J F; Rashid, K H; Redmer, C F; Ripka, M; Rong, G; Rosner, Ch; Ruan, X D; Sarantsev, A; Savrié, M; Schoenning, K; Schumann, S; Shan, W; Shao, M; Shen, C P; Shen, P X; Shen, X Y; Sheng, H Y; Shi, M; Song, W M; Song, X Y; Sosio, S; Spataro, S; Sun, G X; Sun, J F; Sun, S S; Sun, X H; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Tiemens, M; Ullrich, M; Uman, I; Varner, G S; Wang, B; Wang, B L; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, S G; Wang, W; Wang, W P; Wang, X F; Wang, Y; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z H; Wang, Z Y; Wang, Z Y; Weber, T; Wei, D H; Wei, J B; Weidenkaff, P; Wen, S P; Wiedner, U; Wolke, M; Wu, L H; Wu, L J; Wu, Z; Xia, L; Xia, L G; Xia, Y; Xiao, D; Xiao, H; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, J J; Xu, L; Xu, Q J; Xu, Q N; Xu, X P; Yan, L; Yan, W B; Yan, W C; Yan, Y H; Yang, H J; Yang, H X; Yang, L; Yang, Y X; Ye, M; Ye, M H; Yin, J H; Yu, B X; Yu, C X; Yu, J S; Yuan, C Z; Yuan, W L; Yuan, Y; Yuncu, A; Zafar, A A; Zallo, A; Zeng, Y; Zeng, Z; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J; Zhang, J J; Zhang, J L; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, K; Zhang, L; Zhang, S Q; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y N; Zhang, Y T; Zhang, Yu; Zhang, Z H; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, J W; Zhao, J Y; Zhao, J Z; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q W; Zhao, S J; Zhao, T C; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, W J; Zheng, Y H; Zhong, B; Zhou, L; Zhou, X; Zhou, X K; Zhou, X R; Zhou, X Y; Zhu, K; Zhu, K J; Zhu, S; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, J; Zotti, L; Zou, B S; Zou, J H

2017-06-02

Using 4.479×10^{8}  ψ(3686) events collected with the BESIII detector, we search for the decays ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ, where J=0, 1, 2. The decays ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ are observed for the first time. The measured branching fractions are B(ψ(3686)→e^{+}e^{-}χ_{cJ})=(11.7±2.5±1.0)×10^{-4}, (8.6±0.3±0.6)×10^{-4}, (6.9±0.5±0.6)×10^{-4} for J=0, 1, 2, and B(χ_{cJ}→e^{+}e^{-}J/ψ)=(1.51±0.30±0.13)×10^{-4}, (3.73±0.09±0.25)×10^{-3}, (2.48±0.08±0.16)×10^{-3} for J=0, 1, 2, respectively. The ratios of the branching fractions B(ψ(3686)→e^{+}e^{-}χ_{cJ})/B(ψ(3686)→γχ_{cJ}) and B(χ_{cJ}→e^{+}e^{-}J/ψ)/B(χ_{cJ}→γJ/ψ) are also reported. Also, the α values of helicity angular distributions of the e^{+}e^{-} pair are determined for ψ(3686)→e^{+}e^{-}χ_{c1,2} and χ_{c1,2}→e^{+}e^{-}J/ψ.

75 FR 33164 - Modification of Jet Routes J-32, J-38, and J-538; Minnesota

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2009-1080; Airspace Docket No. 09-AGL-13] RIN 2120-AA66 Modification of Jet Routes J-32, J-38, and J-538; Minnesota AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action...

J. J. Thomson goes to America.

PubMed

Downard, Kevin M

2009-11-01

Joseph John (J. J.) Thomson was an accomplished scientist who helped lay the foundations of nuclear physics. A humble man of working class roots, Thomson went on to become one of the most influential physicists of the late 19th century. He is credited with the discovery of the electron, received a Nobel Prize in physics in 1906 for investigations into the conduction of electricity by gases, was knighted in 1908, and served as a Cavendish Professor and Director of the laboratory for over 35 years from 1884. His laboratory attracted some of the world's brightest minds; Francis W. Aston, Niels H. D. Bohr, Hugh L. Callendar, Charles T. R. Wilson, Ernest Rutherford, George F. C. Searle, Geoffrey I. Taylor, and John S. E. Townsend all worked under him. This article recounts J. J. Thomson's visits to North America in 1896, 1903, 1909, and finally 1923. It presents his activities and his personal impressions of the people and society of the U.S.A. and Canada, and the science of atomic physics and chemistry in the late 1800s and early 1900s.

Strange Particles and Heavy Ion Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bassalleck, Bernd; Fields, Douglas

This very long-running grant has supported many experiments in nuclear and particle physics by a group from the University of New Mexico. The gamut of these experiments runs from many aspects of Strangeness Nuclear Physics, to rare Kaon decays, to searches for exotic Hadrons such as Pentaquark or H-Dibaryon, and finally to Spin Physics within the PHENIX collaboration at RHIC. These experiments were performed at a number of laboratories worldwide: first and foremost at Brookhaven National Lab (BNL), but also at CERN, KEK, and most recently at J-PARC. In this Final Technical Report we summarize progress and achievements for thismore » award since our last Progress Report, i.e. for the period of fall 2013 until the award’s termination on November 30, 2015. The report consists of two parts, representing our two most recent experimental efforts, participation in the Nucleon Spin Physics program of the PHENIX experiment at RHIC, the Relativistic Heavy Ion Collider at BNL – Task 1, led by Douglas Fields; and participation in several Strangeness Nuclear Physics experiments at J-PARC, the Japan Proton Accelerator Research Center in Tokai-mura, Japan – Task 2, led by Bernd Bassalleck.« less

C-130J Hercules Transport Aircraft (C-130J)

DTIC Science & Technology

2015-12-01

Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-220 C-130J Hercules Transport Aircraft (C-130J) As of FY 2017 President’s Budget Defense...Acquisition Management Information Retrieval (DAMIR) March 21, 2016 11:33:03 UNCLASSIFIED C-130J December 2015 SAR March 21, 2016 11:33:03...Requirements Document OSD - Office of the Secretary of Defense O&S - Operating and Support PAUC - Program Acquisition Unit Cost C-130J December 2015 SAR March 21

Resonant slepton production yields CMS e e j j and e p Tj j excesses

NASA Astrophysics Data System (ADS)

Allanach, Ben; Biswas, Sanjoy; Mondal, Subhadeep; Mitra, Manimala

2015-01-01

Recent CMS searches for dileptoquark production report local excesses of 2.4 σ in an e e j j channel and 2.6 σ in an e p Tj j channel. Here, we simultaneously explain both excesses with resonant slepton production in R -parity violating supersymmetry. We consider resonant slepton production, which decays to a lepton and a chargino/neutralino, followed by three-body decays of the neutralino/chargino via an R -parity violating coupling. There are regions of parameter space which are also compatible at the 95% confidence level with a 2.8 σ e e j j excess in a recent CMS WR search, while being compatible with other direct search constraints. Phase II of the GERDA neutrinoless double beta decay (0 ν β β ) experiment will probe a sizable portion of the good-fit region.

Investigation of possible phase transition of the frustrated spin-1/2 J 1-J 2-J 3 model on the square lattice.

PubMed

Hu, Ai-Yuan; Wang, Huai-Yu

2017-09-05

The frustrated spin-1/2 J 1 -J 2 -J 3 antiferromagnet with exchange anisotropy on the two-dimensional square lattice is investigated. The exchange anisotropy is presented by η with 0 ≤ η < 1. The effects of the J 1 , J 2 , J 3 and anisotropy on the possible phase transition of the Néel state and collinear state are studied comprehensively. Our results indicate that for J 3  > 0 there are upper limits [Formula: see text] and η c values. When 0 < J 3  ≤ [Formula: see text] and 0 ≤ η ≤ η c , the Néel and collinear states have the same order-disorder transition point at J 2  = J 1 /2. Nevertheless, when the J 3 and η values beyond the upper limits, it is a paramagnetic phase at J 2  = J 1 /2. For J 3  < 0, in the case of 0 ≤ η < 1, the two states always have the same critical temperature as long as J 2  = J 1 /2. Therefore, for J 2  = J 1 /2, under such parameters, a first-order phase transition between the two states for these two cases below the critical temperatures may occur. When J 2  ≠ J 1 /2, the Néel and collinear states may also exist, while they have different critical temperatures. When J 2  > J 1 /2, a first-order phase transition between the two states may also occur. However, for J 2  < J 1 /2, the Néel state is always more stable than the collinear state.

J SERIES MAGAZINE. J 107 NORTH END AND REAR (EAST). ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

J SERIES MAGAZINE. J 107 NORTH END AND REAR (EAST). J 106-103 IN BACKGROUND. - Naval Magazine Lualualei, Headquarters Branch, Inert Storehouse Type, Twelfth Street between Kwajulein & New Mexico Streets, Pearl City, Honolulu County, HI

From rifting to spreading - seismic structure of the rifted western Mariana extinct arc and the ParceVela back-arc basin

NASA Astrophysics Data System (ADS)

Grevemeyer, Ingo; Kodaira, Shuichi; Fujie, Gou; Takahashi, Narumi

2017-04-01

The proto Izu-Ogasawara (Bonin)-Mariana (IBM) Island arc was created when subduction of the Pacific plate began during the Eocene. Today, the Kyushu-Palau Ridge (KPR) at the centre of the Philippine Sea and the western Mariana Ridge (WMR) are considered to be a remnant of the proto IBM Island arc. The KPR and WMR were separated when back-arc spreading began at 30 to 29 Ma in the Shikoku Basin and ParceVela Basin (PVB). Volcanic activity along the arcs diminished at 27 Ma and there is little evidence of volcanic activity between 23-17 Ma. Arc volcanism was reactivated at 15 Ma, when the opening of the Shikoku Basin and PVB ceased. At about 5 Ma the Mariana Basin opened, rifting the WMR from the Mariana arc. Here, we report results from the seismic refraction and wide-angle profile MR101c shot in summer of 2003 by the Japan Agency for Marine-Earth Science and Technology (JAMSTEC) aboard the RV KAIYO during the cruise KY03-06, extending from the PVB across the WMR and terminating just to the east of the WMR. Along MR101c 46 OBS recorded shots from an airgun array of 12,000 cubic inches (197 litres); 44 OBS provided excellent P-wave data, including arrivals sampling the crust (Pg), the crust/mantle boundary (PmP), the uppermost mantle (Pn) and a deep reflection (PnP) under the WMR. To yield the seismic velocity structure, we used a joint reflection and refraction tomography, revealing the crustal and mantle P-wave velocity structure, the seismic Moho, and a deep-seated reflector. Distinct features are a 14 km thick crust forming the WMR, a high-velocity lower crust in both transition zones to the ParceVela Basin and Mariana Basin, and a reflector at 24 km depth, which shallows to 18 km in the transition zone to the Mariana Basin, perhaps reflecting rifting-related thinning of the entire lithosphere. The deep-reflector, however, did not occur under the PVB. Upper mantle velocity below the WMR is <7.5 km/s. High velocities of the lower crust of the WMR flanking the

J SERIES MAGAZINE. J 107 SOUTH ELEVATION. Naval Magazine ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

J SERIES MAGAZINE. J 107 SOUTH ELEVATION. - Naval Magazine Lualualei, Headquarters Branch, Inert Storehouse Type, Twelfth Street between Kwajulein & New Mexico Streets, Pearl City, Honolulu County, HI

Comments on ""Lake Woebegone," Twenty Years Later" by J. J. Cannell, MD

ERIC Educational Resources Information Center

McRae, D. J.

2006-01-01

This article presents the author's comments on ""Lake Woebegone," Twenty Years Later" by J. J. Cannell, MD. J. J. Cannell's article on the so-called "Lake Woebegone" effect for K-12 educational testing systems is mostly an historical account of technical issues and policy considerations that led in part to development…

Applications of a micro-pixel chamber (μPIC) based, time-resolved neutron imaging detector at pulsed neutron beams

NASA Astrophysics Data System (ADS)

Parker, J. D.; Harada, M.; Hattori, K.; Iwaki, S.; Kabuki, S.; Kishimoto, Y.; Kubo, H.; Kurosawa, S.; Matsuoka, Y.; Miuchi, K.; Mizumoto, T.; Nishimura, H.; Oku, T.; Sawano, T.; Shinohara, T.; Suzuki, J.-I.; Takada, A.; Tanimori, T.; Ueno, K.; Ikeno, M.; Tanaka, M.; Uchida, T.

2014-04-01

The realization of high-intensity, pulsed spallation neutron sources such as J-PARC in Japan and SNS in the US has brought time-of-flight (TOF) based neutron techniques to the fore and spurred the development of new detector technologies. When combined with high-resolution imaging, TOF-based methods become powerful tools for direct imaging of material properties, including crystal structure/internal strain, isotopic/temperature distributions, and internal and external magnetic fields. To carry out such measurements in the high-intensities and high gamma backgrounds found at spallation sources, we have developed a new time-resolved neutron imaging detector employing a micro-pattern gaseous detector known as the micro-pixel chamber (μPIC) coupled with a field-programmable-gate-array-based data acquisition system. The detector combines 100μm-level (σ) spatial and sub-μs time resolutions with low gamma sensitivity of less than 10-12 and a rate capability on the order of Mcps (mega-counts-per-second). Here, we demonstrate the application of our detector to TOF-based techniques with examples of Bragg-edge transmission and neutron resonance transmission imaging (with computed tomography) carried out at J-PARC. We also consider the direct imaging of magnetic fields with our detector using polarized neutrons.

J SERIES MAGAZINE. J 107 SOUTH ELEVATION W/POLE. Naval ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

J SERIES MAGAZINE. J 107 SOUTH ELEVATION W/POLE. - Naval Magazine Lualualei, Headquarters Branch, Inert Storehouse Type, Twelfth Street between Kwajulein & New Mexico Streets, Pearl City, Honolulu County, HI

Two-photon exchange correction to the hyperfine splitting in muonic hydrogen

NASA Astrophysics Data System (ADS)

Tomalak, Oleksandr

2017-12-01

We reevaluate the Zemach, recoil and polarizability corrections to the hyperfine splitting in muonic hydrogen expressing them through the low-energy proton structure constants and obtain the precise values of the Zemach radius and two-photon exchange (TPE) contribution. The uncertainty of TPE correction to S energy levels in muonic hydrogen of 105 ppm exceeds the ppm accuracy level of the forthcoming 1S hyperfine splitting measurements at PSI, J-PARC and RIKEN-RAL.

Electrochemistry and Spectroelectrochemistry of Polynuclear Zinc Phthalocyanines: Formation of Mixed Valence Cation Radical Species.

DTIC Science & Technology

1988-02-25

No. No. Copies Cpe Office of Naval Research 2 Dr. David You.)g Attn: Code 1113 Code 334 800 N. Quinc’ Street NORDA Arlington, Virginia 22217-5000 NSTL...Naval Surface Weapons Center Chapel Hill, North Carolina 27514 Silver Spring, Maryland 20910 Or. R. A. Marcus Dr. Michael J. Weaver Department of...Microprocessor model 340 spectrometer. Cyclic and dif, rential pulse voltammetry were performed with a Princeton Applied Research (PARC) model 174A

Instrumental resolution of the chopper spectrometer 4SEASONS evaluated by Monte Carlo simulation

NASA Astrophysics Data System (ADS)

Kajimoto, Ryoichi; Sato, Kentaro; Inamura, Yasuhiro; Fujita, Masaki

2018-05-01

We performed simulations of the resolution function of the 4SEASONS spectrometer at J-PARC by using the Monte Carlo simulation package McStas. The simulations showed reasonably good agreement with analytical calculations of energy and momentum resolutions by using a simplified description. We implemented new functionalities in Utsusemi, the standard data analysis tool used in 4SEASONS, to enable visualization of the simulated resolution function and predict its shape for specific experimental configurations.

J SERIES MAGAZINE. J 106 INTERIOR. BOMB TAILS ON LEFT. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

J SERIES MAGAZINE. J 106 INTERIOR. BOMB TAILS ON LEFT. - Naval Magazine Lualualei, Headquarters Branch, Inert Storehouse Type, Twelfth Street between Kwajulein & New Mexico Streets, Pearl City, Honolulu County, HI

Study of J/ψ→pp̄ and J/ψ→nn̄

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ambrose, D. J.

2012-08-31

The decays J/ψ→pp̄ and J/ψ→nn̄ have been investigated with a sample of 225.2×10⁶ J/ψ events collected with the BESIII detector at the BEPCII e⁺e⁻ collider. The branching fractions are determined to be B(J/ψ→pp̄)=(2.112±0.004±0.031)×10⁻³ and B(J/ψ→nn̄)=(2.07±0.01±0.17)×10⁻³. Distributions of the angle θ between the proton or antineutron and the beam direction are well described by the form 1+αcos²θ, and we find α=0.595±0.012±0.015 for J/ψ→pp̄ and α=0.50±0.04±0.21 for J/ψ→nn̄. Our branching-fraction results suggest a large phase angle between the strong and electromagnetic amplitudes describing the J/ψ→NN¯¯¯ decay.

Status of the RF-driven H{sup −} ion source for J-PARC linac

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oguri, H., E-mail: oguri.hidetomo@jaea.go.jp; Ohkoshi, K.; Ikegami, K.

2016-02-15

For the upgrade of the Japan Proton Accelerator Research Complex linac beam current, a cesiated RF-driven negative hydrogen ion source was installed during the 2014 summer shutdown period, with subsequent operations commencing on September 29, 2014. The ion source has been successfully operating with a beam current and duty factor of 33 mA and 1.25% (500 μs and 25 Hz), respectively. The result of recent beam operation has demonstrated that the ion source is capable of continuous operation for approximately 1100 h. The spark rate at the beam extractor was observed to be at a frequency of less than oncemore » a day, which is an acceptable level for user operation. Although an antenna failure occurred during operation on October 26, 2014, no subsequent serious issues have occurred since then.« less

The containment of toxic wastes: I. Long term metal movement in soils over a covered metalliferous waste heap at Parc lead-zinc mine, North Wales.

PubMed

Shu, J; Bradshaw, A D

1995-01-01

In order to stabilise and contain a toxic metalliferous waste heap at Parc Mine, North Wales, it was covered with 30-40 cm layer of quarry waste in 1977-1978, and sown with a grass/clover seed mixture. This study has examined subsequent metal movement in the cover material and its effect on vegetation. The results, especially when compared with previous observations, give no evidence of upward migration of metals by capillarity in the cover material. Sideways movement of leachate, however, appears to be carrying the metals into the cover material on the sloping sides, giving rise to increasing concentrations of heavy metals in the vegetation and dieback in some places. Root growth on the flat top of the heap is greater than on the slope, but the roots have not penetrated the waste and the contents of Pb, Zn and Cd in surface vegetation remain low. Surface covering of toxic waste with coarse materials restricting capillary rise is therefore a valid reclamation technique so long as lateral movement of toxic leachate can be controlled.

Bacillus subtilis ribonucleases J1 and J2 form a complex with altered enzyme behaviour.

PubMed

Mathy, Nathalie; Hébert, Agnès; Mervelet, Peggy; Bénard, Lionel; Dorléans, Audrey; Li de la Sierra-Gallay, Inés; Noirot, Philippe; Putzer, Harald; Condon, Ciarán

2010-01-01

Ribonucleases J1 and J2 are recently discovered enzymes with dual 5'-to-3' exoribonucleolytic/endoribonucleolytic activity that plays a key role in the maturation and degradation of Bacillus subtilis RNAs. RNase J1 is essential, while its paralogue RNase J2 is not. Up to now, it had generally been assumed that the two enzymes functioned independently. Here we present evidence that RNases J1 and J2 form a complex that is likely to be the predominant form of these enzymes in wild-type cells. While both RNase J1 and the RNase J1/J2 complex have robust 5'-to-3' exoribonuclease activity in vitro, RNase J2 has at least two orders of magnitude weaker exonuclease activity, providing a possible explanation for why RNase J1 is essential. The association of the two proteins also has an effect on the endoribonucleolytic properties of RNases J1 and J2. While the individual enzymes have similar endonucleolytic cleavage activities and specificities, as a complex they behave synergistically to alter cleavage site preference and to increase cleavage efficiency at specific sites. These observations dramatically change our perception of how these ribonucleases function and provide an interesting example of enzyme subfunctionalization after gene duplication.

A family of ParA-like ATPases promotes cell pole maturation by facilitating polar localization of chemotaxis proteins

PubMed Central

Ringgaard, Simon; Schirner, Kathrin; Davis, Brigid M.; Waldor, Matthew K.

2011-01-01

Stochastic processes are thought to mediate localization of membrane-associated chemotaxis signaling clusters in peritrichous bacteria. Here, we identified a new family of ParA-like ATPases (designated ParC [for partitioning chemotaxis]) encoded within chemotaxis operons of many polar-flagellated γ-proteobacteria that actively promote polar localization of chemotaxis proteins. In Vibrio cholerae, a single ParC focus is found at the flagellated old pole in newborn cells, and later bipolar ParC foci develop as the cell matures. The cell cycle-dependent redistribution of ParC occurs by its release from the old pole and subsequent relocalization at the new pole, consistent with a “diffusion and capture” model for ParC dynamics. Chemotaxis proteins encoded in the same cluster as ParC have a similar unipolar-to-bipolar transition; however, they reach the new pole after the arrival of ParC. Cells lacking ParC exhibit aberrantly localized foci of chemotaxis proteins, reduced chemotaxis, and altered motility, which likely accounts for their enhanced colonization of the proximal small intestine in an animal model of cholera. Collectively, our findings indicate that ParC promotes the efficiency of chemotactic signaling processes. In particular, ParC-facilitated development of a functional chemotaxis apparatus at the new pole readies this site for its development into a functional old pole after cell division. PMID:21764856

5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice.

PubMed

Hackler, Elizabeth A; Airey, David C; Shannon, Caitlin C; Sodhi, Monsheel S; Sanders-Bush, Elaine

2006-05-01

Post-transcriptional RNA editing of the G-protein coupled 5-hydroxytryptamine-2C (5-HT(2C)) receptor predicts an array of 24 receptor isoforms, some of which are characterized by reduced constitutive activity and potency to initiate intracellular signaling. The amygdala is integral to anxiety, fear, and related psychiatric diseases. Activation of 5-HT(2C) receptors within the amygdala is anxiogenic. Here, we describe the RNA editing profiles from amygdala of two inbred mouse strains (BALB/cJ and DBA/2J) known to be more anxious than a third (C57BL/6J). We confirmed the strain anxiety differences using light<-->dark exploration, and we discovered that BALB/cJ and DBA/2J are each characterized by a higher functioning RNA editing profile than C57BL/6J. BALB/cJ and DBA/2J exhibit a roughly two-fold reduction in C site editing, and a corresponding two-fold reduction in the edited isoform VSV. C57BL/6J is characterized by a relative decrease in the unedited highly functional isoform INI. We estimated the heritability of editing at the C site to be approximately 40%. By sequencing genomic DNA, we found complete conservation between C57BL/6J, BALB/cJ, DBA/2J and 37 other inbred strains for the RNA edited region of Htr2c, suggesting Htr2c DNA sequence does not influence variation in Htr2c RNA editing between inbred strains of mice. We did, however, discover that serotonin turnover is reduced in BALB/cJ and DBA/2J, consistent with emerging evidence that synaptic serotonin levels regulate RNA editing. These results encourage further study of the causes and consequences of 5-HT(2C) receptor RNA editing in the amygdala of mice.

Crossbar H-mode drift-tube linac design with alternative phase focusing for muon linac

NASA Astrophysics Data System (ADS)

Otani, M.; Futatsukawa, K.; Hasegawa, K.; Kitamura, R.; Kondo, Y.; Kurennoy, S.

2017-07-01

We have developed a Crossbar H-mode (CH) drift-tube linac (DTL) design with an alternative phase focusing (APF) scheme for a muon linac, in order to measure the anomalous magnetic moment and electric dipole moment (EDM) of muons at the Japan Proton Accelerator Research Complex (J-PARC). The CH-DTL accelerates muons from β = v/c = 0.08 to 0.28 at an operational frequency of 324 MHz. The design and results are described in this paper.

Gastrointestinal parasites of mountain gorillas (Gorilla gorilla beringei) in the Parc National des Volcans, Rwanda.

PubMed

Sleeman, J M; Meader, L L; Mudakikwa, A B; Foster, J W; Patton, S

2000-09-01

Ninety-eight fecal samples were collected from 74 free-living mountain gorillas (Gorilla gorilla beringei) from the Parc National des Volcans, Rwanda, between July 1995 and January 1997 and examined for parasites by Sheather's sugar and zinc sulfate flotation methods, trichrome staining, and larval cultures. All samples contained at least one parasite. Seventeen endoparasites were identified, including eight protozoa, seven nematodes, one cestode, and one trematode. Two species of arthropod mite were also recovered from the fecal samples. Parasites observed on fecal examinations included strongyle/trichostrongyle-type eggs (72/74) (representing Oesphagostomum sp., Trichostrongylus sp., Hyostrongylus spp., and possibly Murshidia sp.), Strongyloides sp. (1/74), Trichuris trichiura (2/74), Probstmayria sp. (7/74), Anoplocephala sp. (63/74), Entamoeba hartmanni cysts and trophozoites (19/70), Endolimax nana cysts (31/70), Iodamoeba buetschlii cysts (11/70), Endolimax nana or Iodamoeba buetschlii trophozoites (63/70). Entamoeba coli cysts and trophozoites (14/70), Entamoeba histolytica trophozoite (1/70), Chilomastix sp. cysts and trophozoites (31/70), and Giardia sp. cysts (2/70). In addition, one ascarid and one trematode egg were seen. There were no significant differences in the prevalence of parasites between males and females and between age groups: however, infants and juveniles appeared to have a lower prevalence of Anoplocephala gorillae, and the silverbacked males appeared to have a higher prevalence of Probstmayria sp. Parasite prevalence was consistent among the five social groups studied except Susa group had a significantly lower prevalence of Anoplocephala gorillae. Trichuris trichiura, Strongyloides sp., Chilomastix sp., and Endolimax nana were identified for the first time in this population, and it is possible that these parasites were of human origin. Although there were no obvious clinical effects due to the presence of these parasites, six parasites

I Dream of J.J., or Affordances and Motion Pictures.

ERIC Educational Resources Information Center

Anderson, Joseph D.

1995-01-01

Categorizes attempts to account for how viewers garner meanings from motion pictures as either semiotic, realist, or conventionalist. Proposes an alternative explanation based on J. J. Gibson's ecological theory of perception. Offers his concept of "affordances" as the key to an explanation of how meanings in motion pictures are…

DETAIL OF CORNERSTONE, WHICH STATES "J.J. DANIELS, BUILDER 1861." NOTE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL OF CORNERSTONE, WHICH STATES "J.J. DANIELS, BUILDER 1861." NOTE ALSO IRON STRAP AT EAST CORNER OF ABUTMENT. - Jackson Covered Bridge, Spanning Sugar Creek, CR 775N (Changed from Spanning Sugar Creek), Bloomingdale, Parke County, IN

The Navy’s Next-Generation Tropical Cyclone Model

DTIC Science & Technology

2009-09-30

when compared with the Doppler radar observations (Fig. 6c). An example of a real-time COAMPS-TC forecast during T- PARC /TCS-08 initialized on 26...prediction support for the THORPEX-Pacific Asian Campaign (T- PARC ) and the Tropical Cyclone Structure 2008 (TCS-08) (T- PARC /TCS-08) experiments...implemented from the CBLAST project. In support of the T- PARC /TCS-08 campaign, adaptive observing guidance for tropical cyclones has been provided

Control of Expression of the RNases J1 and J2 in Bacillus subtilis

PubMed Central

Jamalli, Ailar; Hébert, Agnès; Zig, Léna

2014-01-01

In Bacillus subtilis, the dual activity 5′ exo- and endoribonucleases J1 and J2 are important players in mRNA and stable RNA maturation and degradation. Recent work has improved our understanding of their structure and mechanism of action and identified numerous RNA substrates. However, almost nothing is known about the expression of these enzymes. Here, we have identified the transcriptional and translational signals that control the expression of the rnjA (RNase J1) and rnjB (RNase J2) genes. While the rnjB gene is transcribed constitutively from a sigma A promoter, optimal expression of RNase J1 requires cotranscription and cotranslation with the upstream ykzG gene, encoding a protein of unknown function. In the absence of coupled translation, RNase J1 expression is decreased more than 5-fold. Transcription of the ykzG operon initiates at a sigma A promoter with a noncanonical −35 box that is required for optimal transcription. Biosynthesis of RNase J1 is autocontrolled within a small range (1.4-fold) and also slightly stimulated (1.4-fold) in the absence of RNase J2. These controls are weak but might be useful to maintain the overall RNase J level and possibly also equimolar amounts of the two nucleases in the cell that primarily act as a heterodimer in vivo. PMID:24187087

J-tube technique for double-j stent insertion during laparoscopic upper urinary tract surgical procedures.

PubMed

Kim, Hyung Suk; Lee, Byung Ki; Jung, Jin-Woo; Lee, Jung Keun; Byun, Seok-Soo; Lee, Sang Eun; Jeong, Chang Wook

2014-11-01

Double-J stent insertion has been generally performed during laparoscopic upper urinary tract (UUT) surgical procedures to prevent transient urinary tract obstruction and postoperative flank pain from ureteral edema and blood clots. Several restrictive conditions that make this procedure difficult and time consuming, however, include the coiled distal ends of the flexible Double-J stent and the limited bending angle of the laparoscopic instruments. To overcome these limitations, we devised a Double-J stent insertion method using the new J-tube technique. Between July 2011 and May 2013, Double-J stents were inserted using the J-tube technique in 33 patients who underwent a laparoscopic UUT surgical procedure by a single surgeon. The mean stent placement time was 4.8±2.7 minutes, and there were no intraoperative complications. In conclusion, the J-tube technique is a safe and time-saving method for Double-J stent insertion during laparoscopic surgical procedures.

[Occupational risk during pregnancy and sick leave in a cohort of workers from Parc de Salut Mar (Barcelona, Spain)].

PubMed

Villar, Rocío; Benavides, Fernando G; Serra, Laura; Serra, Consol

2018-06-15

To study the use of the Pregnancy occupational risk benefit (PORB) and non-work related sickness absence (NWSA) in a cohort of pregnant workers of Parc de Salut Mar, Barcelona (Spain). Retrospective cohort study of 428 pregnant workers between 2010 and 2014, who were followed-up until delivery. Absences from work, both PORB and NWSA were recorded until the beginning of their maternity leave. The sequence analysis identifies four trajectories, which are described according to workers demographic and job characteristics. Of the total cohort, 56 (13.1%) accessed only the PORB, representing 6.126 days of absence; 68 (15.9%) also accessed PORB, with 7.127 days of absence, but had previously accumulated 102 episodes of NWSA with 1.820 days of absence. The majority of pregnant workers in the sample (69.9%) took only one or several episodes of NWSA without using PORB, with 545 episodes and 26,337 days of absence. Most were active during the first quarter and it is from the second quarter that episodes of long-term NWSA appeared. During the last month of pregnancy more than 80% of the workers were absent from work. Pregnant workers remained at work for two thirds of their pregnancy. Absences were mainly due to episodes of NWSA. PORB represented one third of them. As in other similar countries, our results suggest a change in the management of social protection benefits for pregnant workers. Copyright © 2018 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

Determination of the number of J/ψ events with inclusive J/ψ decays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ai, X. C.

A measurement of the number of J/ψ events collected with the BESIII detector in 2009 and 2012 is performed using inclusive decays of the J/ψ. The number of J/ψ events taken in 2009 is recalculated to be (223.7 ± 1.4) × 10 6, which is in good agreement with the previous measurement, but with significantly improved precision due to improvements in the BESIII software. The number of J/ψ events taken in 2012 is determined to be (1086.9 ± 6.0) × 10 6. In total, the number of J/ψ events collected with the BESIII detector is measured to be (1310.6 ±more » 7.0) × 10 6, where the uncertainty is dominated by systematic effects and the statistical uncertainty is negligible.« less

Determination of the number of J/ψ events with inclusive J/ψ decays

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ai, X. C.; ...

2016-08-26

A measurement of the number of J/ψ events collected with the BESIII detector in 2009 and 2012 is performed using inclusive decays of the J/ψ. The number of J/ψ events taken in 2009 is recalculated to be (223.7 ± 1.4) × 10 6, which is in good agreement with the previous measurement, but with significantly improved precision due to improvements in the BESIII software. The number of J/ψ events taken in 2012 is determined to be (1086.9 ± 6.0) × 10 6. In total, the number of J/ψ events collected with the BESIII detector is measured to be (1310.6 ±more » 7.0) × 10 6, where the uncertainty is dominated by systematic effects and the statistical uncertainty is negligible.« less

Visualization of Proton and Electron Transfer Processes of a Biochemical Reaction by μSR

NASA Astrophysics Data System (ADS)

Kiyotani, Tamiko; Kobayashi, Masayoshi; Tanaka, Ichiro; Niimura, Nobuo

For the last several years, we have discussed and conducted experiments toward realization of visualization of electron and proton transfer process in an enzyme reaction using muon. As the first step for exploring the useful application of the μSR for the biological system, which is "μSR in Biology". A first μSR experiment on biochemical reaction was conducted using the complex of a digestive enzyme, a kind of serine-protease and the inhibitor at J-PARC and PSI.

Searching for planetary nebulae at the Galactic halo via J-PAS and J-PLUS

NASA Astrophysics Data System (ADS)

Goncalves, Denise R.; Aparício-Villegas, Teresa; Akras, Stavros; Borges Fernandes, Marcelo; J-PAS Collaboration

2015-08-01

The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is a narrow-band imaging, very wide field cosmological survey to be carried out from a dedicated 2.5m telescope and a 4.7 sq.deg camera with 1.2Gpix. It will last 5 years and will observe 8500 sq.deg of Northern sky to a 5-σ magnitude depth for point sources, equivalent to i ~23.3 over an aperture of 2 arcsec2. The J-PAS filter system consists of 54 contiguous narrow band filters of 145-Å FWHM, from 3,500 to 10,000Å. Two broad-band filters will be added at the extremes, UV and IR, plus 3 SDSS g, r, and i filters. The Javalambre Photometric Local Universe Survye (J-PLUS) will be an auxiliary survey ofJ-PAS (mainly for calibration) with a dedicated 0.80m telescope. J-PLUS comprises 12 filters, including g, r, i and z SDSS ones. Though about 2,500 planetary nebulae (PNe, confirmed spectroscopically) are known in the Galaxy, only 14 objects have been convincingly identified as halo PNe. They were classified as such from their location, kinematics and chemistry. Halo PNe are able to reveal precious information for the study of low- and intermediate-mass star evolution and the early chemical conditions of the Galaxy. The characteristic low continuum and intense line emissions of PNe make them good objects to be searched by J-PAS, and even by J-PLUS. For instance, the halo PNe BoBn 1, DdDm 1 and PS 1, located somewhere between 11 and 24 kpc from the Sun, have B magnitudes of 16, 14 and 13.4, respectively. Such values are easily encompassed by J-PAS/J-PLUS, given the typical limit magnitude of the survey. Though covering a significantly smaller sky area, data from the ALHAMBRA survey were used to test our J-PAS/J-PLUS strategy to search for PNe. Our first results will be shown in this poster.

Vertical transmission of avian leukosis virus subgroup J (ALV-J) from hens infected through artificial insemination with ALV-J infected semen.

PubMed

Li, Yang; Cui, Shuai; Li, Weihua; Wang, Yixin; Cui, Zhizhong; Zhao, Peng; Chang, Shuang

2017-06-29

Avian leukosis virus (ALV) is one of the main causes of tumour development within the poultry industry in China. The subgroup J avian leukosis viruses (ALV-J), which induce erythroblastosis and myelocytomatosis, have the greatest pathogenicity and transmission ability within this class of viruses. ALV can be transmitted both horizontally and vertically; however, the effects of ALV infection in chickens-especially roosters-during the propagation, on future generations is not clear. Knowing the role of the cock in the transmission of ALV from generation to generation might contribute to the eradication programs for ALV. The results showed that two hens inseminated with ALV-J-positive semen developed temporary antibody responses to ALV-J at 4-5 weeks post insemination. The p27 antigen was detected in cloacal swabs of six hens, and in 3 of 26 egg albumens at 1-6 weeks after insemination. Moreover, no viremia was detected at 6 weeks after insemination even when virus isolation had been conducted six times at weekly intervals for each of the 12 females. However, ALV-J was isolated from 1 of their 34 progeny chicks at 1 week of age, and its gp85 had 98.4%-99.2% sequence identity with the gp85 of ALV-J isolated from semen samples of the six cocks. Our findings indicated that females that were late horizontally infected with ALV-J by artificial insemination might transmit the virus to progeny through eggs, which amounts to vertical transmission.

Performance characterization of polarimetric active radar calibrators and a new single antenna design

NASA Astrophysics Data System (ADS)

Sarabandi, Kamal; Oh, Yisok; Ulaby, Fawwaz T.

1992-10-01

Three aspects of a polarimetric active radar calibrator (PARC) are treated: (1) experimental measurements of the magnitudes and phases of the scattering-matrix elements of a pair of PARCs operating at 1.25 and 5.3 GHz; (2) the design, construction, and performance evaluation of a PARC; and (3) the extension of the single-target-calibration technique (STCT) to a PARC. STCT has heretofore been limited to the use of reciprocal passive calibration devices, such as spheres and trihedral corner reflectors.

Performance characterization of polarimetric active radar calibrators and a new single antenna design

NASA Technical Reports Server (NTRS)

Sarabandi, Kamal; Oh, Yisok; Ulaby, Fawwaz T.

1992-01-01

Three aspects of a polarimetric active radar calibrator (PARC) are treated: (1) experimental measurements of the magnitudes and phases of the scattering-matrix elements of a pair of PARCs operating at 1.25 and 5.3 GHz; (2) the design, construction, and performance evaluation of a PARC; and (3) the extension of the single-target-calibration technique (STCT) to a PARC. STCT has heretofore been limited to the use of reciprocal passive calibration devices, such as spheres and trihedral corner reflectors.

Sociability and brain development in BALB/cJ and C57BL/6J mice

PubMed Central

Fairless, Andrew H.; Dow, Holly C.; Kreibich, Arati Sadalge; Torre, Matthew; Kuruvilla, Mariyam; Gordon, Elliot; Morton, Elizabeth A.; Tan, Junhao; Berrettini, Wade H.; Li, Hongzhe; Abel, Ted; Brodkin, Edward S.

2012-01-01

Sociability—the tendency to seek social interaction–propels the development of social cognition and social skills, but is disrupted in autism spectrum disorders (ASD). BALB/cJ and C57BL/6J inbred mouse strains are useful models of low and high levels of juvenile sociability, respectively, but the neurobiological and developmental factors that account for the strains’ contrasting sociability levels are largely unknown. We hypothesized that BALB/cJ mice would show increasing sociability with age but that C57BL/6J mice would show high sociability throughout development. We also hypothesized that littermates would resemble one another in sociability more than non-littermates. Finally, we hypothesized that low sociability would be associated with low corpus callosum size and increased brain size in BALB/cJ mice. Separate cohorts of C57BL/6J and BALB/cJ mice were tested for sociability at 19-, 23-, 31-, 42-, or 70-days-of-age, and brain weights and mid-sagittal corpus callosum area were measured. BALB/cJ sociability increased with age, and a strain by age interaction in sociability between 31 and 42 days of age suggested strong effects of puberty on sociability development. Sociability scores clustered according to litter membership in both strains, and perinatal litter size and sex ratio were identified as factors that contributed to this clustering in C57BL/6J, but not BALB/cJ, litters. There was no association between corpus callosum size and sociability, but smaller brains were associated with lower sociability in BALB/cJ mice. The associations reported here will provide directions for future mechanistic studies of sociability development. PMID:22178318

Nova Sco 2011 No. 2 = PNV J16364440-4132340 = PNV J16364300-4132460

NASA Astrophysics Data System (ADS)

Waagen, Elizabeth O.

2011-09-01

Announcement of discovery of Nova Sco 2011 No. 2 = PNV J16364440-4132340 = PNV J16364300-4132460. Discovered independently by John Seach (Chatsworth Island, NSW, Australia, on 2011 Sep. 06.37 UT at mag=9.8 (DSLR)) and by Yuji Nakamura (Kameyama, Mie, Japan, on 2011 Sep. 06.4313 UT at mag=9.7 C (CCD)). Posted on the IAU Central Bureau for Astronomical Telegrams Transient Object Confirmation Page (TOCP) as PNV J16364440-4132340 (Nakamura) and PNV J16364300-4132460 (Seach); identifications consolidated in VSX under PNV J16364440-4132340. Spectra obtained by A. Arai et al. on 2011 Sep. 7.42 UT suggest a highly reddened Fe II-type classical nova. Spectra by F. Walter and J. Seron obtained Sep. 2011 8.091 UT confirm a young galactic nova; they report spectra are reminiscent of an early recurrent nova. Initially announced in AAVSO Special Notice #251 (Matthew Templeton) and IAU Central Bureau Electronic Telegram 2813 (Daniel W. E. Green, ed.). Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details and observations.

Branching fraction measurement of J /ψ →KSKL and search for J /ψ →KSKS

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Albrecht, M.; Alekseev, M.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bai, Y.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X. R.; Chen, Y. B.; Chen, Z. X.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dorjkhaidav, O.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Y. G.; Gao, Z.; Garillon, B.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, S.; Gu, Y. T.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y. P.; Haddadi, Z.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, X. Q.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, S. H.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jin, Y.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Khan, T.; Khoukaz, A.; Kiese, P.; Kliemt, R.; Koch, L.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kuemmel, M.; Kuhlmann, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Lavezzi, L.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, K.; Li, K.; Li, K. J.; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. H.; Liu, H. H.; Liu, H. M.; Liu, J. B.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, Ke; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqing; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Meng, Z. X.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Morello, G.; Muchnoi, N. Yu.; Muramatsu, H.; Mustafa, A.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Pellegrino, J.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Pitka, A.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qi, T. Y.; Qian, S.; Qiao, C. F.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Richter, M.; Ripka, M.; Rolo, M.; Rong, G.; Rosner, Ch.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, J. J.; Song, W. M.; Song, X. Y.; Sosio, S.; Sowa, C.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, L.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. K.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, G. Y.; Tang, X.; Tapan, I.; Tiemens, M.; Tsednee, B. T.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, B. Q.; Wang, D.; Wang, D. Y.; Wang, Dan; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Wei, J. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Y. J.; Xiao, Z. J.; Xie, X. H.; Xie, Y. G.; Xie, Y. H.; Xiong, X. A.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. H.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, J.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2017-12-01

Using a sample of 1.31 ×109 J /ψ events collected with the BESIII detector at the BEPCII collider, we study the decays of J /ψ →KSKL and KSKS . The branching fraction of J /ψ →KSKL is determined to be B (J /ψ →KSKL)=(1.93 ±0.01 (stat )±0.05 (syst ))×10-4 , which significantly improves on previous measurements. No clear signal is observed for the J /ψ →KSKS process, and the upper limit at the 95% confidence level for its branching fraction is determined to be B (J /ψ →KSKS)<1.4 ×10-8 , which improves on the previous searches by 2 orders in magnitude and reaches the order of the Einstein-Podolsky-Rosen expectation.

Sociability and brain development in BALB/cJ and C57BL/6J mice.

PubMed

Fairless, Andrew H; Dow, Holly C; Kreibich, Arati Sadalge; Torre, Matthew; Kuruvilla, Mariyam; Gordon, Elliot; Morton, Elizabeth A; Tan, Junhao; Berrettini, Wade H; Li, Hongzhe; Abel, Ted; Brodkin, Edward S

2012-03-17

Sociability--the tendency to seek social interaction--propels the development of social cognition and social skills, but is disrupted in autism spectrum disorders (ASD). BALB/cJ and C57BL/6J inbred mouse strains are useful models of low and high levels of juvenile sociability, respectively, but the neurobiological and developmental factors that account for the strains' contrasting sociability levels are largely unknown. We hypothesized that BALB/cJ mice would show increasing sociability with age but that C57BL/6J mice would show high sociability throughout development. We also hypothesized that littermates would resemble one another in sociability more than non-littermates. Finally, we hypothesized that low sociability would be associated with low corpus callosum size and increased brain size in BALB/cJ mice. Separate cohorts of C57BL/6J and BALB/cJ mice were tested for sociability at 19-, 23-, 31-, 42-, or 70-days-of-age, and brain weights and mid-sagittal corpus callosum area were measured. BALB/cJ sociability increased with age, and a strain by age interaction in sociability between 31 and 42 days of age suggested strong effects of puberty on sociability development. Sociability scores clustered according to litter membership in both strains, and perinatal litter size and sex ratio were identified as factors that contributed to this clustering in C57BL/6J, but not BALB/cJ, litters. There was no association between corpus callosum size and sociability, but smaller brains were associated with lower sociability in BALB/cJ mice. The associations reported here will provide directions for future mechanistic studies of sociability development. Copyright © 2011 Elsevier B.V. All rights reserved.

Laurence J. Capellas

ERIC Educational Resources Information Center

Nishimoto, Warren

2007-01-01

Laurence J. Capellas, teacher, principal, and administrator in the Hawai'i Department of Education from 1935 to 1977. Laurence J. Capellas was born in 1913 in Hakalau to two Hawai'i island school-teachers. After attending Hakalau School, St. Mary's School in Hilo, and St. Louis College in Honolulu, he went on to the University of Hawai'i Teachers…

Optical spectroscopy of SN2014J

NASA Astrophysics Data System (ADS)

Kotak, R.

2014-01-01

Authors: J. Polshaw, R. Kotak, J. R. Maund, S. J. Smartt (QUB), M. Fraser, N. Walton (IoA), J. M. Abreu (IAC), M. Balcells, C. Benn, J. Mendez, A. Oscoz, O. Zamora, C. Zurita (ING) A spectrum of the supernova SN 2014J in the nearby galaxy M82 was obtained on Jan. 23.2 2014 (UT) at the 2.54m Isaac Newton Telescope (INT) with IDS and the grating R1200R (approximate wavelength range 5600 - 7500A, at 2A resolution).

Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice.

PubMed

Dow, H C; Kreibich, A S; Kaercher, K A; Sankoorikal, G M V; Pauley, E D; Lohoff, F W; Ferraro, T N; Li, H; Brodkin, E S

2011-02-01

Aggressive behaviors are disabling, treatment refractory, and sometimes lethal symptoms of several neuropsychiatric disorders. However, currently available treatments for patients are inadequate, and the underlying genetics and neurobiology of aggression is only beginning to be elucidated. Inbred mouse strains are useful for identifying genomic regions, and ultimately the relevant gene variants (alleles) in these regions, that affect mammalian aggressive behaviors, which, in turn, may help to identify neurobiological pathways that mediate aggression. The BALB/cJ inbred mouse strain exhibits relatively high levels of intermale aggressive behaviors and shows multiple brain and behavioral phenotypes relevant to neuropsychiatric syndromes associated with aggression. The A/J strain shows very low levels of aggression. We hypothesized that a cross between BALB/cJ and A/J inbred strains would reveal genomic loci that influence the tendency to initiate intermale aggressive behavior. To identify such loci, we conducted a genomewide scan in an F2 population of 660 male mice bred from BALB/cJ and A/J inbred mouse strains. Three significant loci on chromosomes 5, 10 and 15 that influence aggression were identified. The chromosome 5 and 15 loci are completely novel, and the chromosome 10 locus overlaps an aggression locus mapped in our previous study that used NZB/B1NJ and A/J as progenitor strains. Haplotype analysis of BALB/cJ, NZB/B1NJ and A/J strains showed three positional candidate genes in the chromosome 10 locus. Future studies involving fine genetic mapping of these loci as well as additional candidate gene analysis may lead to an improved biological understanding of mammalian aggressive behaviors. © 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

Surface Wind Field Analyses of Tropical Cyclones During TCS-08: Relative Impacts of Aircraft and Remotely-Sensed Observations

DTIC Science & Technology

2009-09-01

Campaign (T- PARC ). Rare aircraft measurements in the western North Pacific are utilized to define surface wind distributions of TY Nuri, TY Sinlaku...The Observing System Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaign (T- PARC ). Rare aircraft measurements in the...3 C. TCS08/T- PARC ................................................................................................... 4 D

7. Detail view of 1866 cornerstone (J.J. Havis and M.F. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Detail view of 1866 cornerstone (J.J. Havis and M.F. Echols, Builders). This cornerstone was moved to the third floor, west elevation of an addition built in 1899. - Riverdale Cotton Mill, Corner of Middle & Lower Streets, Valley, Chambers County, AL

STS-51J Mission Insignia

NASA Technical Reports Server (NTRS)

1985-01-01

The 51-J mission insignia, designed by Atlantis's first crew, pays tribute to the Statue of Liberty and the ideas it symbolizes. The historical gateway figure bears additional significance for Astronauts Karol J. Bobko, mission commander; and Ronald J. Grabe, pilot, both New Your Natives.

Developments of a new data acquisition system at ANNRI

NASA Astrophysics Data System (ADS)

Nakao, T.; Terada, K.; Kimura, A.; Nakamura, S.; Iwamoto, O.; Harada, H.; Katabuchi, T.; Igashira, M.; Hori, J.

2017-09-01

A new data acquisition system (DAQ system) has been developed at the Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) facility in the Japan Proton Accelerator Research Complex, Materials and Life Science Experimental Facility (J-PARC/MLF). DAQ systems for both the Ge detector system and the Li-glass detector system were tested by using a gold sample. The applicability of the time-of-flight method was checked. System performance was evaluated on the basis of digital conversion nonlinearity, energy resolution, multi-channel coincidence and dead time.

30 CFR Appendix A to Subpart J of... - Appendix A to Subpart J of Part 75

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Appendix A to Subpart J of Part 75 A Appendix A to Subpart J of Part 75 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Medium-Voltage Alternating Current Circuits Pt. 75, Subpt. J, App. A Appendix A to Subpart J of Part 75...

Noise Strength Estimates of Three SGRs: Swift J1822.3-1606, SGR J1833-0832 and Swift J1834.9-0846

NASA Astrophysics Data System (ADS)

Serim, M. M.; Inam, S. Ç.; Baykal, A.

2012-12-01

We studied timing solutions of the three magnetars SWIFT J1822.3-1606, SGR J1833-0832 and Swift J1834.9-0846. We extracted the residuals of pulse arrival times with respect to the constant pulse frequency derivative. Using polynomial estimator techniques, we estimated the noise strengths of the sources. Our results showed that the noise strength and spin-down rate are strongly correlated, indicating that increase in spin-down rate leads to more torque noise on the magnetars. We are in progress of extending our analysis to the other magnetars.

Fabrication of Supramolecular Chirality from Achiral Molecules at the Liquid/Liquid Interface Studied by Second Harmonic Generation.

PubMed

Lin, Lu; Zhang, Zhen; Guo, Yuan; Liu, Minghua

2018-01-09

We present the investigation into the supramolecular chirality of 5-octadecyloxy-2-(2-pyridylazo)phenol (PARC18) at water/1,2-dichloroethane interface by second harmonic generation (SHG). We observe that PARC18 molecules form supramolecular chirality through self-assembly at the liquid/liquid interface although they are achiral molecules. The bulk concentration of PARC18 in the organic phase has profound effects on the supramolecular chirality. By increasing bulk concentration, the enantiomeric excess at the interface first grows and then decreases until it eventually vanishes. Further analysis reveals that the enantiomeric excess is determined by the twist angle of PARC18 molecules at the interface rather than their orientational angle. At lower and higher bulk concentrations, the average twist angle of PARC18 molecules approaches zero, and the assemblies are achiral; whereas at medium bulk concentrations, the average twist angle is nonzero, so that the assemblies show supramolecular chirality. We also estimate the coverage of PARC18 molecules at the interface versus the bulk concentration and fit it to Langmuir adsorption model. The result indicates that PARC18 assemblies show strongest supramolecular chirality in a half-full monolayer. These findings highlight the opportunities for precise control of supramolecular chirality at liquid/liquid interfaces by manipulating the bulk concentration.

Observation of the decay B-->J/psietaK and search for X(3872)-->J/psieta.

PubMed

Aubert, B; Barate, R; Boutigny, D; Couderc, F; Gaillard, J M; Hicheur, A; Karyotakis, Y; Lees, J P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; LeClerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Morgan, S E; Watson, A T; Watson, N K; Fritsch, M; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Steinke, M; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; Wilson, F F; Abe, K; Cuhadar-Donszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Eschrich, I; Kirkby, D; Lankford, A J; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Gary, J W; Shen, B C; Wang, K; del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, Sh; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Smith, J G; van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zeng, Q; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Feltresi, E; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, J; Schubert, K R; Schwierz, R; Spaan, B; Bernard, D; Bonneaud, G R; Brochard, F; Grenier, P; Thiebaux, Ch; Vasileiadis, G; Verderi, M; Bard, D J; Khan, A; Lavin, D; Muheim, F; Playfer, S; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Sarti, A; Treadwell, E; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Patteri, P; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Brandenburg, G; Morii, M; Won, E; Dubitzky, R S; Langenegger, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Gaillard, J R; Morton, G W; Nash, J A; Taylor, G P; Grenier, G J; Lee, S J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Cheng, C H; Lange, D J; Simani, M C; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, E; Gamet, R; Kay, M; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Harrison, P F; Mohanty, G B; Brown, C L; Cowan, G; Flack, R L; Flaecher, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Hart, P A; Hodgkinson, M C; Lafferty, G D; Lyon, A J; Williams, J C; Farbin, A; Hulsbergen, W D; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Staengle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M; Raven, G; Wilden, L; Jessop, C P; LoSecco, J M; Gabriel, T A; Allmendinger, T; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Ter-Antonyan, R; Wong, Q K; Brau, J; Frey, R; Igonkina, O; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; de la Vaissière, Ch; Del Buono, L; Hamon, O; John, M J J; Leruste, Ph; Ocariz, J; Pivk, M; Roos, L; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Anulli, F; Biasini, M; Peruzzi, I M; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Del Gamba, V; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martinez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lu, C; Miftakov, V; Olsen, J; Smith, A J S; Varnes, E W; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Tehrani, F Safai; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P F; Hamel de Monchenault, G; Kozanecki, W; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yèche, Ch; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmueller, O L; Convery, M R; Cristinziani, M; De Nardo, G; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Elsen, E E; Field, R C; Glanzman, T; Gowdy, S J; Hadig, T; Halyo, V; Hryn'ova, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Libby, J; Luitz, S; Luth, V; Lynch, H L; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Va'vra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Young, C C; Burchat, P R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, S; Alam, M S; Ernst, J A; Saeed, M A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Satpathy, A; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bona, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Hollar, J J; Johnson, J R; Kutter, P E; Li, H; Liu, R; Di Lodovico, F; Mihalyi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; Tan, P; von Wimmersperg-Toeller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H

2004-07-23

We report the observation of the B meson decay B+/- -->J/psietaK+/- and evidence for the decay B0-->J/psietaK0S, using 90 x 10(6) BB; events collected at the Upsilon(4S) resonance with the BABAR detector at the SLAC PEP-II e+e- asymmetric-energy storage ring. We obtain branching fractions of B(B+/- -->J/psietaK+/-) = [10.8 +/- 2.3(stat) +/- 2.4(syst)] x 10(-5) and B(B0-->J/psietaK0S) = [8.4 +/- 2.6(stat) +/- 2.7(syst)] x 10(-5). We search for the new narrow mass state, the X(3872), recently reported by the Belle Collaboration, in the decay B+/- -->X(3872)K+/-,X(3872)-->J/psieta and determine an upper limit of B[B +/- -->X(3872)K+/- -->J/psietaK+/-] < 7.7 x 10(-6) at 90% confidence level. Copyright 2004 The American Physical Society

Katherine J. Chou | NREL

Science.gov Websites

J. Chou Photo of Katherine J. Chou Katherine Chou Microbial Physiology & Engineering , Clostridium thermocellum, through metabolic engineering. "Biological Electron Transfer and Catalysis principles governing substrate utilization. "Advance Biofuels from Cellulose via Genetic Engineering of

Elementary Particle Physics and High Energy Phenomena: Final Report for FY2010-13

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cumalat, John P.; de Alwis, Senarath P.; DeGrand, Thomas A.

2013-06-27

The work under this grant consists of experimental, theoretical, and phenomenological research on the fundamental properties of high energy subnuclear particles. The work is conducted at the University of Colorado, the European Organization for Nuclear Research (CERN), the Japan Proton Accelerator Research Complex (J-PARC), Fermi National Accelerator Laboratory (FNAL), SLAC National Accelerator Laboratory (SLAC), Los Alamos National Laboratory (LANL), and other facilities, employing neutrino-beam experiments, test beams of various particles, and proton-proton collider experiments. It emphasizes mass generation and symmetry-breaking, neutrino oscillations, bottom particle production and decay, detector development, supergravity, supersymmetry, superstrings, quantum chromodynamics, nonequilibrium statistical mechanics, cosmology, phase transitions,more » lattice gauge theory, and anomaly-free theories. The goals are to improve our understanding of the basic building blocks of matter and their interactions. Data from the Large Hadron Collider at CERN have revealed new interactions responsible for particle mass, and perhaps will lead to a more unified picture of the forces among elementary material constituents. To this end our research includes searches for manifestations of theories such as supersymmetry and new gauge bosons, as well as the production and decay of heavy-flavored quarks. Our current work at J-PARC, and future work at new facilities currently under conceptual design, investigate the specifics of how the neutrinos change flavor. The research is integrated with the training of students at all university levels, benefiting both the manpower and intellectual base for future technologies.« less

On Nulling, Drifting, and Their Interactions in PSRs J1741-0840 and J1840-0840

NASA Astrophysics Data System (ADS)

Gajjar, V.; Yuan, J. P.; Yuen, R.; Wen, Z. G.; Liu, Z. Y.; Wang, N.

2017-12-01

We report detailed investigation of nulling and drifting behavior of two pulsars PSRs J1741-0840 and J1840-0840 observed from the Giant Meterwave Radio Telescope at 625 MHz. PSR J1741-0840 was found to show a nulling fraction (NF) of around 30% ± 5% while PSR J1840-0840 was shown to have an NF of around 50% ± 6%. We measured drifting behavior from different profile components in PSR J1840-0840 for the first time with the leading component showing drifting with 13.5 ± 0.7 periods while the weak trailing component showed drifting of around 18 ± 1 periods. Large nulling hampers accuracy of these quantities derived using standard Fourier techniques. A more accurate comparison was drawn from driftband slopes, measured after sub-pulse modeling. These measurements revealed interesting sporadic and irregular drifting behavior in both pulsars. We conclude that the previously reported different drifting periodicities in the trailing component of PSR J1741-0840 is likely due to the spread in these driftband slopes. We also find that both components of PSR J1840-0840 show similar driftband slopes within the uncertainties. Unique nulling-drifting interaction is identified in PSR J1840-0840 where, on most occasions, the pulsar tends to start nulling after what appears to be the end of a driftband. Similarly, when the pulsar switches back to an emission phase, on most occasions it starts at the beginning of a new driftband in both components. Such behaviors have not been detected in any other pulsars to our knowledge. We also found that PSR J1741-0840 seems to have no memory of its previous burst phase while PSR J1840-0840 clearly exhibits memory of its previous state even after longer nulls for both components. We discuss possible explanations for these intriguing nulling-drifting interactions seen in both pulsars based on various pulsar nulling models.

Molecular Mechanisms of Fluoroquinolone Resistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

PubMed Central

Jalal, Shah; Ciofu, Oana; Høiby, Niels; Gotoh, Naomasa; Wretlind, Bengt

2000-01-01

Twenty P. aeruginosa isolates were collected from six cystic fibrosis (CF) patients, aged 27 to 33, in 1994 (9 isolates) and 1997 (11 isolates) at the CF Center, Copenhagen, Denmark, and were typed by pulse-field gel electrophoresis (PFGE) or ribotyping. Five of the patients had isolates with the same PFGE or ribotyping patterns in 1997 as in 1994, and ciprofloxacin had a two- to fourfold higher MIC for the isolates collected in 1997 than those from 1994. Genomic DNA was amplified for gyrA, parC, mexR, and nfxB by PCR and sequenced. Eleven isolates had mutations in gyrA, seven isolates had mutations at codon 83 (Thr to Ile), and four isolates had mutations at codon 87 (Asp to Asn or Tyr). Sixteen isolates had mutations in nfxB at codon 82 (Arg to Leu). Increased amounts of OprN were found in six isolates and OprJ in eight isolates as determined by immunoblotting. No isolates had mutations in parC or mexR. Six isolates had mutations in efflux pumps without gyrA mutations. The average number of mutations was higher in isolates from 1997 than in those from 1994. The results also suggested that efflux resistance mechanisms are more common in isolates from CF patients than in strains from urine and wounds from non-CF patients, in which mutations in gyrA and parC dominate (S. Jalal and B. Wretlind, Microb. Drug Resist. 4:257–261, 1998). PMID:10681343

Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of Bs0 meson decays to J/ψη and J/ψη'

NASA Astrophysics Data System (ADS)

Aaij, R.; Abellan Beteta, C.; Adametz, A.; Adeva, B.; Adinolfi, M.; Adrover, C.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amhis, Y.; Anderlini, L.; Anderson, J.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Bachmann, S.; Back, J. J.; Baesso, C.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Bates, A.; Bauer, Th.; Bay, A.; Beddow, J.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Benayoun, M.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blanks, C.; Blouw, J.; Blusk, S.; Bobrov, A.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Bowcock, T. J. V.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N. H.; Brown, H.; Büchler-Germann, A.; Burducea, I.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Callot, O.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cattaneo, M.; Cauet, Ch.; Charles, M.; Charpentier, Ph.; Chen, P.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coca, C.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Corti, G.; Couturier, B.; Cowan, G. A.; Craik, D.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; David, P.; David, P. N. Y.; De Bonis, I.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Degaudenzi, H.; Del Buono, L.; Deplano, C.; Derkach, D.; Deschamps, O.; Dettori, F.; Dickens, J.; Dijkstra, H.; Diniz Batista, P.; Domingo Bonal, F.; Donleavy, S.; Dordei, F.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; van Eijk, D.; Eisele, F.; Eisenhardt, S.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Elsby, D.; Esperante Pereira, D.; Falabella, A.; Färber, C.; Fardell, G.; Farinelli, C.; Farry, S.; Fave, V.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fitzpatrick, C.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Furcas, S.; Gallas Torreira, A.; Galli, D.; Gandelman, M.; Gandini, P.; Gao, Y.; Garnier, J.-C.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gibson, V.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hampson, T.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; Harrison, P. F.; Hartmann, T.; He, J.; Heijne, V.; Hennessy, K.; Henrard, P.; Hernando Morata, J. A.; van Herwijnen, E.; Hicks, E.; Hill, D.; Hoballah, M.; Hopchev, P.; Hulsbergen, W.; Hunt, P.; Huse, T.; Hussain, N.; Huston, R. S.; Hutchcroft, D.; Hynds, D.; Iakovenko, V.; Ilten, P.; Imong, J.; Jacobsson, R.; Jaeger, A.; Jahjah Hussein, M.; Jans, E.; Jansen, F.; Jaton, P.; Jean-Marie, B.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Jost, B.; Kaballo, M.; Kandybei, S.; Karacson, M.; Karbach, M.; Keaveney, J.; Kenyon, I. R.; Kerzel, U.; Ketel, T.; Keune, A.; Khanji, B.; Kim, Y. M.; Kochebina, O.; Komarov, I.; Komarov, V.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leroy, O.; Lesiak, T.; Li, L.; Li, Y.; Li Gioi, L.; Liles, M.; Lindner, R.; Linn, C.; Liu, B.; Liu, G.; von Loeben, J.; Lopes, J. H.; Lopez Asamar, E.; Lopez-March, N.; Lu, H.; Luisier, J.; Mac Raighne, A.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Magnin, J.; Maino, M.; Malde, S.; Manca, G.; Mancinelli, G.; Mangiafave, N.; Marconi, U.; Märki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martin, L.; Martín Sánchez, A.; Martinelli, M.; Martinez Santos, D.; Massafferri, A.; Mathe, Z.; Matteuzzi, C.; Matveev, M.; Maurice, E.; Mazurov, A.; McCarthy, J.; McGregor, G.; McNulty, R.; Meissner, M.; Merk, M.; Merkel, J.; Milanes, D. A.; Minard, M.-N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morawski, P.; Mountain, R.; Mous, I.; Muheim, F.; Müller, K.; Muresan, R.; Muryn, B.; Muster, B.; Mylroie-Smith, J.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neufeld, N.; Nguyen, A. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Nikitin, N.; Nikodem, T.; Nomerotski, A.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Orlandea, M.; Otalora Goicochea, J. M.; Owen, P.; Pal, B. K.; Palano, A.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrick, G. N.; Patrignani, C.; Pavel-Nicorescu, C.; Pazos Alvarez, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perego, D. L.; Perez Trigo, E.; Pérez-Calero Yzquierdo, A.; Perret, P.; Perrin-Terrin, M.; Pessina, G.; Petridis, K.; Petrolini, A.; Phan, A.; Picatoste Olloqui, E.; Pie Valls, B.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Playfer, S.; Plo Casasus, M.; Polci, F.; Polok, G.; Poluektov, A.; Polycarpo, E.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pugatch, V.; Puig Navarro, A.; Qian, W.; Rademacker, J. H.; Rakotomiaramanana, B.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redford, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, A.; Rinnert, K.; Rives Molina, V.; Roa Romero, D. A.; Robbe, P.; Rodrigues, E.; Rodriguez Perez, P.; Rogers, G. J.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Sabatino, G.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salzmann, C.; Sanmartin Sedes, B.; Sannino, M.; Santacesaria, R.; Santamarina Rios, C.; Santinelli, R.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schaack, P.; Schiller, M.; Schindler, H.; Schleich, S.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shatalov, P.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, O.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, M.; Sobczak, K.; Soler, F. J. P.; Solomin, A.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stoica, S.; Stone, S.; Storaci, B.; Straticiuc, M.; Straumann, U.; Subbiah, V. K.; Swientek, S.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Teodorescu, E.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M. T.; Tsaregorodtsev, A.; Tuning, N.; Ubeda Garcia, M.; Ukleja, A.; Urner, D.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Videau, I.; Vieira, D.; Vilasis-Cardona, X.; Visniakov, J.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, H.; Voß, C.; Waldi, R.; Wallace, R.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Webber, A. D.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wiggers, L.; Wilkinson, G.; Williams, M. P.; Williams, M.; Wilson, F. F.; Wishahi, J.; Witek, M.; Witzeling, W.; Wotton, S. A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, F.; Xing, Z.; Yang, Z.; Young, R.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhong, L.; Zvyagin, A.; LHCb Collaboration

2013-02-01

First evidence of the B0→J/ψω decay is found and the Bs0→J/ψη and Bs0→J/ψη' decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb-1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of √{s}=7 TeV. The branching fractions of these decays are measured relative to that of the B0→J/ψρ0 decay: {B(B0→J/ψω)}/{B(B0→J/ψρ0)}=0.89±0.19(stat)-0.13+0.07(syst), {B(B}/{s0→J/ψη)B(B0→J/ψρ0)}=14.0±1.2(stat)-1.5+1.1(syst)-1.0+1.1(fd/fs), {B(B}/{s0→J/ψη')B(B0→J/ψρ0)}=12.7±1.1(stat)-1.3+0.5(syst)-0.9+1.0(fd/fs), where the last uncertainty is due to the knowledge of fd/fs, the ratio of b-quark hadronization factors that accounts for the different production rate of B0 and Bs0 mesons. The ratio of the branching fractions of Bs0→J/ψη' and Bs0→J/ψη decays is measured to be {B(B}/{s0→J/ψη')B(Bs0→J/ψη)}=0.90±0.09(stat)-0.02+0.06(syst).

The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice

PubMed Central

2014-01-01

Background The liver plays a major role in regulating metabolic homeostasis and is vital for nutrient metabolism. Identifying the genetic factors regulating these processes could lead to a greater understanding of how liver function responds to a high-fat diet and how that response may influence susceptibilities to obesity and metabolic syndrome. In this study we examine differences in hepatic gene expression between the LG/J and SM/J inbred mouse strains and how gene expression in these strains is affected by high-fat diet. LG/J and SM/J are known to differ in their responses to a high-fat diet for a variety of obesity- and diabetes-related traits, with the SM/J strain exhibiting a stronger phenotypic response to diet. Results Dietary intake had a significant effect on gene expression in both inbred lines. Genes up-regulated by a high-fat diet were involved in biological processes such as lipid and carbohydrate metabolism; protein and amino acid metabolic processes were down regulated on a high-fat diet. A total of 259 unique transcripts exhibited a significant diet-by-strain interaction. These genes tended to be associated with immune function. In addition, genes involved in biochemical processes related to non-alcoholic fatty liver disease (NAFLD) manifested different responses to diet between the two strains. For most of these genes, SM/J had a stronger response to the high-fat diet than LG/J. Conclusions These data show that dietary fat impacts gene expression levels in SM/J relative to LG/J, with SM/J exhibiting a stronger response. This supports previous data showing that SM/J has a stronger phenotypic response to high-fat diet. Based upon these findings, we suggest that SM/J and its cross with the LG/J strain provide a good model for examining non-alcoholic fatty liver disease and its role in metabolic syndrome. PMID:24499025

SlideJ: An ImageJ plugin for automated processing of whole slide images.

PubMed

Della Mea, Vincenzo; Baroni, Giulia L; Pilutti, David; Di Loreto, Carla

2017-01-01

The digital slide, or Whole Slide Image, is a digital image, acquired with specific scanners, that represents a complete tissue sample or cytological specimen at microscopic level. While Whole Slide image analysis is recognized among the most interesting opportunities, the typical size of such images-up to Gpixels- can be very demanding in terms of memory requirements. Thus, while algorithms and tools for processing and analysis of single microscopic field images are available, Whole Slide images size makes the direct use of such tools prohibitive or impossible. In this work a plugin for ImageJ, named SlideJ, is proposed with the objective to seamlessly extend the application of image analysis algorithms implemented in ImageJ for single microscopic field images to a whole digital slide analysis. The plugin has been complemented by examples of macro in the ImageJ scripting language to demonstrate its use in concrete situations.

SlideJ: An ImageJ plugin for automated processing of whole slide images

PubMed Central

Baroni, Giulia L.; Pilutti, David; Di Loreto, Carla

2017-01-01

The digital slide, or Whole Slide Image, is a digital image, acquired with specific scanners, that represents a complete tissue sample or cytological specimen at microscopic level. While Whole Slide image analysis is recognized among the most interesting opportunities, the typical size of such images—up to Gpixels- can be very demanding in terms of memory requirements. Thus, while algorithms and tools for processing and analysis of single microscopic field images are available, Whole Slide images size makes the direct use of such tools prohibitive or impossible. In this work a plugin for ImageJ, named SlideJ, is proposed with the objective to seamlessly extend the application of image analysis algorithms implemented in ImageJ for single microscopic field images to a whole digital slide analysis. The plugin has been complemented by examples of macro in the ImageJ scripting language to demonstrate its use in concrete situations. PMID:28683129

Future long-baseline neutrino oscillations: View from Asia

NASA Astrophysics Data System (ADS)

Hayato, Yoshinari

2015-07-01

Accelerator based long-baseline neutrino oscillation experiments have been playing important roles in revealing the nature of neutrinos. However, it turned out that the current experiments are not sufficient to study two major remaining problems, the CP violation in the lepton sector and the mass hierarchy of neutrinos. Therefore, several new experiments have been proposed. Among of them, two accelerator based long-baseline neutrino oscillation experiments, the J-PARC neutrino beam and Hyper-Kamiokande, and MOMENT, have been proposed in Asia. These two projects are reviewed in this article.

Baby MIND: A Magnetised Spectrometer for the WAGASCI Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Antonova, M.; et al.

The WAGASCI experiment being built at the J-PARC neutrino beam line will measure the difference in cross sections from neutrinos interacting with a water and scintillator targets, in order to constrain neutrino cross sections, essential for the T2K neutrino oscillation measurements. A prototype Magnetised Iron Neutrino Detector (MIND), called Baby MIND, is being constructed at CERN to act as a magnetic spectrometer behind the main WAGASCI target to be able to measure the charge and momentum of the outgoing muon from neutrino charged current interactions.

1. Photocopied December 1977, from original in 'Report of J.B.J.,'Vol. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopied December 1977, from original in 'Report of J.B.J.,'Vol. I, Jervis Library. ELEVATION OF SING SING KILL BRIDGE, SHOWING ORIGINAL PLAN FOR AN 80-FOOT ARCH. - Old Croton Aqueduct, Sing Sing Kill Bridge, Spanning Aqueduct Street & Broadway, Ossining, Westchester County, NY

Nicholas J. Nagle | NREL

Science.gov Websites

presentation. Featured Publications "Impact of biomass processing, blending and densification, on J. Nagle Photo of Nicholas J. Nagle Nicholas Nagle Researcher IV-Chemical Engineering Nick.Nagle impact on lignin upgrading post conversion. As feedstocks rapidly evolve into new formats, such as

Phase diagram of the frustrated J 1 ‑ J 2 transverse field Ising model on the square lattice

NASA Astrophysics Data System (ADS)

Sadrzadeh, M.; Langari, A.

2018-03-01

We study the zero-temperature phase diagram of transverse field Ising model on the J 1 ‑ J 2 square lattice. In zero magnetic field, the model has a classical Néel phase for J 2/J 1 < 0.5 and an antiferromagnetic collinear phase for J 2/J 1 > 0.5. We incorporate harmonic fluctuations by using linear spin wave theory (LSWT) with single spin flip excitations above a magnetic order background and obtain the phase diagram of the model in this approximation. We find that harmonic quantum fluctuations of LSWT fail to lift the large degeneracy at J 2/J 1 = 0.5 and exhibit some inconsistent regions on the phase diagram. However, we show that anharmonic fluctuations of cluster operator approach (COA) resolve the inconsistency of the LSWT, which reveals a string-valence bond solid ordered phase for the highly frustrated region.

Search for the Θ+ pentaquark via the π(-)p→K(-)X reaction at 1.92 GeV/c.

PubMed

Shirotori, K; Takahashi, T N; Adachi, S; Agnello, M; Ajimura, S; Aoki, K; Bhang, H C; Bassalleck, B; Botta, E; Bufalino, S; Chiga, N; Evtoukhovitch, P; Feliciello, A; Fujioka, H; Hiruma, F; Honda, R; Hosomi, K; Ichikawa, Y; Ieiri, M; Igarashi, Y; Imai, K; Ishibashi, N; Ishimoto, S; Itahashi, K; Iwasaki, R; Joo, C W; Kim, M J; Kim, S J; Kiuchi, R; Koike, T; Komatsu, Y; Kulikov, V V; Marcello, S; Masumoto, S; Matsuoka, K; Miwa, K; Moritsu, M; Nagae, T; Naruki, M; Niiyama, M; Noumi, H; Ozawa, K; Saito, N; Sakaguchi, A; Sako, H; Samoilov, V; Sato, M; Sato, S; Sato, Y; Sawada, S; Sekimoto, M; Sugimura, H; Suzuki, S; Takahashi, H; Takahashi, T; Tamura, H; Tanaka, T; Tanida, K; Tokiyasu, A O; Tomida, N; Tsamalaidze, Z; Ukai, M; Yagi, K; Yamamoto, T O; Yang, S B; Yonemoto, Y; Yoon, C J; Yoshida, K

2012-09-28

The Θ(+) pentaquark baryon was searched for via the π(-)p→K(-)X reaction with a missing mass resolution of 1.4 MeV/c(2) (FWHM) at the Japan Proton Accelerator Research Complex (J-PARC). π(-) meson beams were incident on the liquid hydrogen target with a beam momentum of 1.92 GeV/c. No peak structure corresponding to the Θ(+) mass was observed. The upper limit of the production cross section averaged over the scattering angle of 2° to 15° in the laboratory frame is obtained to be 0.26 μb/sr in the mass region of 1.51-1.55 GeV/c(2). The upper limit of the Θ(+) decay width is obtained to be 0.72 and 3.1 MeV for J(Θ)(P)=1/2(+) and J(Θ)(P)=1/2(-), respectively, using the effective Lagrangian approach.

Neuronal Tryptophan Hydroxylase Expression in BALB/cJ and C57Bl/6J Mice

PubMed Central

Bach, Helene; Arango, Victoria; Huang, Yung-Yu; Leong, Sharlene; Mann, J. John; Underwood, Mark D.

2014-01-01

BALB/c is an inbred stress-sensitive mouse strain exhibiting low brain serotonin (5-HT) content and a 5-HT biosynthetic enzyme tryptophan hydroxylase (Tph2) variant reported to have lower catalytic activity compared to other inbred base strains. To evaluate other mechanisms that may explain low 5-HT, we compared BALB/cJ mice and a control inbred strain C57Bl/6J mice, for expression of Tph2 mRNA, TPH2 protein and regional levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). Tph2 mRNA and TPH2 protein in brainstem dorsal raphe nuclei (DRN) was assayed by in situ hybridization and immunocytochemistry respectively. 5-HT and 5-HIAA were determined by high pressure liquid chromatography (HPLC). BALB/cJ mice had 20% less Tph2 mRNA and 28% fewer TPH2 immunolabeled neurons than C57Bl/6J mice (t = -2.59, p = 0.02). The largest difference in Tph2 transcript expression was in rostral DRN (t = 2.731, p = 0.008). 5-HT was 15% lower in the midbrain of BALB/cJ compared to C57Bl/6J mice (p < 0.05). The behavioral differences in BALB/cJ mice relative to the C57Bl/6J strain may be due in part, to fewer 5-HT neurons and lower Tph2 gene expression resulting in less 5-HT neurotransmission. Future studies quantifying expression per neuron are needed to determine whether less expression is explained by fewer neurons or also less expression per neuron, or both. PMID:21740442

Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice.

PubMed

Bach, Helene; Arango, Victoria; Huang, Yung-Yu; Leong, Sharlene; Mann, J John; Underwood, Mark D

2011-09-01

BALB/c is an inbred stress-sensitive mouse strain exhibiting low brain serotonin (5-HT) content and a 5-HT biosynthetic enzyme tryptophan hydroxylase (Tph2) variant reported to have lower catalytic activity compared with other inbred base strains. To evaluate other mechanisms that may explain low 5-HT, we compared BALB/cJ mice and a control inbred strain C57Bl/6J mice, for expression of Tph2 mRNA, TPH2 protein and regional levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid. Tph2 mRNA and TPH2 protein in brainstem dorsal raphe nuclei was assayed by in situ hybridization and immunocytochemistry respectively. 5-HT and 5-hydroxyindoleacetic acid were determined by HPLC. BALB/cJ mice had 20% less Tph2 mRNA and 28% fewer TPH2 immunolabeled neurons than C57Bl/6J mice (t = -2.59, p = 0.02). The largest difference in Tph2 transcript expression was in rostral dorsal raphe nuclei (t = 2.731, p = 0.008). 5-HT was 15% lower in the midbrain and 18% lower in the cerebral cortex of BALB/cJ compared with C57Bl/6J mice (p < 0.05). The behavioral differences in BALB/cJ mice relative to the C57Bl/6J strain may be due in part, to fewer 5-HT neurons and lower Tph2 gene expression resulting in less 5-HT neurotransmission. Future studies quantifying expression per neuron are needed to determine whether less expression is explained by fewer neurons or also less expression per neuron, or both. © 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry.

Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of Bs0 meson decays to J/ψη and J/ψη‧

NASA Astrophysics Data System (ADS)

LHCb Collaboration; Aaij, R.; Abellan Beteta, C.; Adametz, A.; Adeva, B.; Adinolfi, M.; Adrover, C.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amhis, Y.; Anderlini, L.; Anderson, J.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Bachmann, S.; Back, J. J.; Baesso, C.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Bates, A.; Bauer, Th.; Bay, A.; Beddow, J.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Benayoun, M.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blanks, C.; Blouw, J.; Blusk, S.; Bobrov, A.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Bowcock, T. J. V.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N. H.; Brown, H.; Büchler-Germann, A.; Burducea, I.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Callot, O.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cattaneo, M.; Cauet, Ch.; Charles, M.; Charpentier, Ph.; Chen, P.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coca, C.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Corti, G.; Couturier, B.; Cowan, G. A.; Craik, D.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; David, P.; David, P. N. Y.; De Bonis, I.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Degaudenzi, H.; Del Buono, L.; Deplano, C.; Derkach, D.; Deschamps, O.; Dettori, F.; Dickens, J.; Dijkstra, H.; Diniz Batista, P.; Domingo Bonal, F.; Donleavy, S.; Dordei, F.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; van Eijk, D.; Eisele, F.; Eisenhardt, S.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Elsby, D.; Esperante Pereira, D.; Falabella, A.; Färber, C.; Fardell, G.; Farinelli, C.; Farry, S.; Fave, V.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fitzpatrick, C.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Furcas, S.; Gallas Torreira, A.; Galli, D.; Gandelman, M.; Gandini, P.; Gao, Y.; Garnier, J.-C.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gibson, V.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hampson, T.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; Harrison, P. F.; Hartmann, T.; He, J.; Heijne, V.; Hennessy, K.; Henrard, P.; Hernando Morata, J. A.; van Herwijnen, E.; Hicks, E.; Hill, D.; Hoballah, M.; Hopchev, P.; Hulsbergen, W.; Hunt, P.; Huse, T.; Hussain, N.; Huston, R. S.; Hutchcroft, D.; Hynds, D.; Iakovenko, V.; Ilten, P.; Imong, J.; Jacobsson, R.; Jaeger, A.; Jahjah Hussein, M.; Jans, E.; Jansen, F.; Jaton, P.; Jean-Marie, B.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Jost, B.; Kaballo, M.; Kandybei, S.; Karacson, M.; Karbach, M.; Keaveney, J.; Kenyon, I. R.; Kerzel, U.; Ketel, T.; Keune, A.; Khanji, B.; Kim, Y. M.; Kochebina, O.; Komarov, I.; Komarov, V.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leroy, O.; Lesiak, T.; Li, L.; Li, Y.; Li Gioi, L.; Liles, M.; Lindner, R.; Linn, C.; Liu, B.; Liu, G.; von Loeben, J.; Lopes, J. H.; Lopez Asamar, E.; Lopez-March, N.; Lu, H.; Luisier, J.; Mac Raighne, A.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Magnin, J.; Maino, M.; Malde, S.; Manca, G.; Mancinelli, G.; Mangiafave, N.; Marconi, U.; Märki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martin, L.; Martín Sánchez, A.; Martinelli, M.; Martinez Santos, D.; Massafferri, A.; Mathe, Z.; Matteuzzi, C.; Matveev, M.; Maurice, E.; Mazurov, A.; McCarthy, J.; McGregor, G.; McNulty, R.; Meissner, M.; Merk, M.; Merkel, J.; Milanes, D. A.; Minard, M.-N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morawski, P.; Mountain, R.; Mous, I.; Muheim, F.; Müller, K.; Muresan, R.; Muryn, B.; Muster, B.; Mylroie-Smith, J.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neufeld, N.; Nguyen, A. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Nikitin, N.; Nikodem, T.; Nomerotski, A.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Orlandea, M.; Otalora Goicochea, J. M.; Owen, P.; Pal, B. K.; Palano, A.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrick, G. N.; Patrignani, C.; Pavel-Nicorescu, C.; Pazos Alvarez, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perego, D. L.; Perez Trigo, E.; Pérez-Calero Yzquierdo, A.; Perret, P.; Perrin-Terrin, M.; Pessina, G.; Petridis, K.; Petrolini, A.; Phan, A.; Picatoste Olloqui, E.; Pie Valls, B.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Playfer, S.; Plo Casasus, M.; Polci, F.; Polok, G.; Poluektov, A.; Polycarpo, E.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pugatch, V.; Puig Navarro, A.; Qian, W.; Rademacker, J. H.; Rakotomiaramanana, B.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redford, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, A.; Rinnert, K.; Rives Molina, V.; Roa Romero, D. A.; Robbe, P.; Rodrigues, E.; Rodriguez Perez, P.; Rogers, G. J.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Sabatino, G.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salzmann, C.; Sanmartin Sedes, B.; Sannino, M.; Santacesaria, R.; Santamarina Rios, C.; Santinelli, R.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schaack, P.; Schiller, M.; Schindler, H.; Schleich, S.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shatalov, P.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, O.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, M.; Sobczak, K.; Soler, F. J. P.; Solomin, A.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stoica, S.; Stone, S.; Storaci, B.; Straticiuc, M.; Straumann, U.; Subbiah, V. K.; Swientek, S.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Teodorescu, E.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M. T.; Tsaregorodtsev, A.; Tuning, N.; Ubeda Garcia, M.; Ukleja, A.; Urner, D.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Videau, I.; Vieira, D.; Vilasis-Cardona, X.; Visniakov, J.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, H.; Voß, C.; Waldi, R.; Wallace, R.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Webber, A. D.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wiggers, L.; Wilkinson, G.; Williams, M. P.; Williams, M.; Wilson, F. F.; Wishahi, J.; Witek, M.; Witzeling, W.; Wotton, S. A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, F.; Xing, Z.; Yang, Z.; Young, R.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhong, L.; Zvyagin, A.

2013-02-01

First evidence of the B0→J/ψω decay is found and the Bs0→J/ψη and Bs0→J/ψη‧ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb-1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of s=7 TeV. The branching fractions of these decays are measured relative to that of the B0→J/ψρ0 decay:B(B0→J/ψω)B(B0→J/ψρ0)=0.89±0.19(stat)-0.13+0.07(syst), B(Bs0→J/ψη)B(B0→J/ψρ0)=14.0±1.2(stat)-1.5+1.1(syst)-1.0+1.1(fdfs), B(Bs0→J/ψη‧)B(B0→J/ψρ0)=12.7±1.1(stat)-1.3+0.5(syst)-0.9+1.0(fdfs), where the last uncertainty is due to the knowledge of fd/fs, the ratio of b-quark hadronization factors that accounts for the different production rate of B0 and Bs0 mesons. The ratio of the branching fractions of Bs0→J/ψη‧ and Bs0→J/ψη decays is measured to beB(Bs0→J/ψη‧)B(Bs0→J/ψη)=0.90±0.09(stat)-0.02+0.06(syst).

76 FR 39156 - R. J. Corman Railroad Company/Bardstown Line-Lease and Operation Exemption-R. J. Corman Railroad...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35364] R. J. Corman Railroad Company/Bardstown Line--Lease and Operation Exemption--R. J. Corman Railroad Property, LLC R. J... notice of exemption under 49 CFR 1150.41 to lease from R. J. Corman Railroad Property, LLC (RJC Railroad...

The thymus of the hairless rhino-j (hr/hr-j) mice

PubMed Central

SAN JOSE, I.; GARCÍA-SUÁREZ, O.; HANNESTAD, J.; CABO, R.; GAUNA, L.; REPRESA, J.; VEGA, J. A.

2001-01-01

The hairless (hr) gene is expressed in a large number of tissues, primarily the skin, and a mutation in the hr gene is responsible for the typical cutaneous phenotype of hairless mice. Mutant hr mouse strains show immune defects involving especially T cells and macrophages, as well as an age-related immunodeficiency and an accelerated atrophy of the thymus. These data suggest that the hr mutation causes a defect of this organ, although hr transcripts have not been detected in fetal or adult mice thymus. The present study analyses the thymus of young (3 mo) and adult (9 mo) homozygous hr-rh-j mice (a strain of hairless mice) by means of structural techniques and immunohistochemistry to selectively identify thymic epithelial cells, dendritic cells, and macrophages. There were structural alterations in the thymus of both young and adult rh-rh-j mice, which were more severe in older animals. These alterations consisted of relative cortical atrophy, enlargement of blood vessels, proliferation of perivascular connective tissue, and the appearance of cysts. hr-rh-j mice also showed a decrease in the number of epithelial and dendritic cells, and macrophages. Taken together, present results strongly suggest degeneration and accelerated age-dependent regression of the thymus in hr-rh-j mice, which could explain at least in part the immune defects reported in hairless mouse strains. PMID:11327202

Daniel J. Friedman | NREL

Science.gov Websites

solar cells for concentrator systems. One of his early focuses after joining the group was to adapt the J. Friedman Photo of Daniel J. Friedman. Daniel Friedman Group Research Manager III-Physics manager of the High Efficiency Crystalline Photovoltaics Group. He received his doctorate in applied

Study of J/ψ Production in Jets.

PubMed

Aaij, R; Adeva, B; Adinolfi, M; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Archilli, F; d'Argent, P; Arnau Romeu, J; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Babuschkin, I; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baker, S; Balagura, V; Baldini, W; Baranov, A; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Baryshnikov, F; Baszczyk, M; Batozskaya, V; Batsukh, B; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Beiter, A; Bel, L J; Bellee, V; Belloli, N; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Beranek, S; Berezhnoy, A; Bernet, R; Bertolin, A; Betancourt, C; Betti, F; Bettler, M-O; van Beuzekom, M; Bezshyiko, Ia; Bifani, S; Billoir, P; Bird, T; Birnkraut, A; Bitadze, A; Bizzeti, A; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Boettcher, T; Bondar, A; Bondar, N; Bonivento, W; Bordyuzhin, I; Borgheresi, A; Borghi, S; Borisyak, M; Borsato, M; Bossu, F; Boubdir, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britsch, M; Britton, T; Brodzicka, J; Buchanan, E; Burr, C; Bursche, A; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D H; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cavallero, G; Cenci, R; Chamont, D; Charles, M; Charpentier, Ph; Chatzikonstantinidis, G; Chefdeville, M; Chen, S; Cheung, S-F; Chobanova, V; Chrzaszcz, M; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collazuol, G; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombs, G; Coquereau, S; Corti, G; Corvo, M; Costa Sobral, C M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Da Cunha Marinho, F; Dall'Occo, E; Dalseno, J; David, P N Y; Davis, A; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Serio, M; De Simone, P; Dean, C T; Decamp, D; Deckenhoff, M; Del Buono, L; Demmer, M; Dendek, A; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Dijkstra, H; Dordei, F; Dorigo, M; Dosil Suárez, A; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Dungs, K; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Déléage, N; Easo, S; Ebert, M; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Farley, N; Farry, S; Fay, R; Fazzini, D; Ferguson, D; Fernandez, G; Fernandez Prieto, A; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fini, R A; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fleuret, F; Fohl, K; Fontana, M; Fontanelli, F; Forshaw, D C; Forty, R; Franco Lima, V; Frank, M; Frei, C; Fu, J; Funk, W; Furfaro, E; Färber, C; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; Garcia Martin, L M; García Pardiñas, J; Garra Tico, J; Garrido, L; Garsed, P J; Gascon, D; Gaspar, C; Gavardi, L; Gazzoni, G; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gizdov, K; Gligorov, V V; Golubkov, D; Golutvin, A; Gomes, A; Gorelov, I V; Gotti, C; Govorkova, E; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Greim, R; Griffith, P; Grillo, L; Gruberg Cazon, B R; Grünberg, O; Gushchin, E; Guz, Yu; Gys, T; Göbel, C; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hamilton, B; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hatch, M; He, J; Head, T; Heister, A; Hennessy, K; Henrard, P; Henry, L; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hombach, C; Hopchev, H; Hulsbergen, W; Humair, T; Hushchyn, M; Hutchcroft, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jawahery, A; Jiang, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Karacson, M; Kariuki, J M; Karodia, S; Kecke, M; Kelsey, M; Kenzie, M; Ketel, T; Khairullin, E; Khanji, B; Khurewathanakul, C; Kirn, T; Klaver, S; Klimaszewski, K; Klimkovich, T; Koliiev, S; Kolpin, M; Komarov, I; Koppenburg, P; Kosmyntseva, A; Kozachuk, A; Kozeiha, M; Kravchuk, L; Kreplin, K; Kreps, M; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kurek, K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Leflat, A; Lefrançois, J; Lefèvre, R; Lemaitre, F; Lemos Cid, E; Leroy, O; Lesiak, T; Leverington, B; Li, T; Li, Y; Likhomanenko, T; Lindner, R; Linn, C; Lionetto, F; Liu, X; Loh, D; Longstaff, I; Lopes, J H; Lucchesi, D; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusiani, A; Lyu, X; Machefert, F; Maciuc, F; Maev, O; Maguire, K; Malde, S; Malinin, A; Maltsev, T; Manca, G; Mancinelli, G; Manning, P; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marinangeli, M; Marino, P; Marks, J; Martellotti, G; Martin, M; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massacrier, L M; Massafferri, A; Matev, R; Mathad, A; Mathe, Z; Matteuzzi, C; Mauri, A; Maurice, E; Maurin, B; Mazurov, A; McCann, M; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Melnychuk, D; Merk, M; Merli, A; Michielin, E; Milanes, D A; Minard, M-N; Mitzel, D S; Mogini, A; Molina Rodriguez, J; Monroy, I A; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Morgunova, O; Moron, J; Morris, A B; Mountain, R; Muheim, F; Mulder, M; Mussini, M; Müller, D; Müller, J; Müller, K; Müller, V; Naik, P; Nakada, T; Nandakumar, R; Nandi, A; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, T D; Nguyen-Mau, C; Nieswand, S; Niet, R; Nikitin, N; Nikodem, T; Nogay, A; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Ogilvy, S; Okhrimenko, O; Oldeman, R; Onderwater, C J G; Otalora Goicochea, J M; Otto, A; Owen, P; Oyanguren, A; Pais, P R; Palano, A; Palutan, M; Papanestis, A; Pappagallo, M; Pappalardo, L L; Parker, W; Parkes, C; Passaleva, G; Pastore, A; Patel, G D; Patel, M; Patrignani, C; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perret, P; Pescatore, L; Petridis, K; Petrolini, A; Petrov, A; Petruzzo, M; Picatoste Olloqui, E; Pietrzyk, B; Pikies, M; Pinci, D; Pistone, A; Piucci, A; Placinta, V; Playfer, S; Plo Casasus, M; Poikela, T; Polci, F; Poluektov, A; Polyakov, I; Polycarpo, E; Pomery, G J; Ponce, S; Popov, A; Popov, D; Popovici, B; Poslavskii, S; Potterat, C; Price, E; Price, J D; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Quagliani, R; Rachwal, B; Rademacker, J H; Rama, M; Ramos Pernas, M; Rangel, M S; Raniuk, I; Ratnikov, F; Raven, G; Redi, F; Reichert, S; Dos Reis, A C; Remon Alepuz, C; Renaudin, V; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Robbe, P; Rodrigues, A B; Rodrigues, E; Rodriguez Lopez, J A; Rodriguez Perez, P; Rogozhnikov, A; Roiser, S; Rollings, A; Romanovskiy, V; Romero Vidal, A; Ronayne, J W; Rotondo, M; Rudolph, M S; Ruf, T; Ruiz Valls, P; Saborido Silva, J J; Sadykhov, E; Sagidova, N; Saitta, B; Salustino Guimaraes, V; Sanchez Gonzalo, D; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santimaria, M; Santovetti, E; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrina, D; Schael, S; Schellenberg, M; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmelzer, T; Schmidt, B; Schneider, O; Schopper, A; Schreiner, H F; Schubert, K; Schubiger, M; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Semennikov, A; Sergi, A; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Siddi, B G; Silva Coutinho, R; Silva de Oliveira, L; Simi, G; Simone, S; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, E; Smith, I T; Smith, J; Smith, M; Soares Lavra, L; Sokoloff, M D; Soler, F J P; Souza De Paula, B; Spaan, B; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Stefko, P; Stefkova, S; Steinkamp, O; Stemmle, S; Stenyakin, O; Stevens, H; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Stracka, S; Stramaglia, M E; Straticiuc, M; Straumann, U; Sun, L; Sutcliffe, W; Swientek, K; Syropoulos, V; Szczekowski, M; Szumlak, T; T'Jampens, S; Tayduganov, A; Tekampe, T; Tellarini, G; Teubert, F; Thomas, E; van Tilburg, J; Tilley, M J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Topp-Joergensen, S; Toriello, F; Tournefier, E; Tourneur, S; Trabelsi, K; Traill, M; Tran, M T; Tresch, M; Trisovic, A; Tsaregorodtsev, A; Tsopelas, P; Tully, A; Tuning, N; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vacca, C; Vagnoni, V; Valassi, A; Valat, S; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; van Veghel, M; Velthuis, J J; Veltri, M; Veneziano, G; Venkateswaran, A; Vernet, M; Vesterinen, M; Viana Barbosa, J V; Viaud, B; Vieira, D; Vieites Diaz, M; Viemann, H; Vilasis-Cardona, X; Vitti, M; Volkov, V; Vollhardt, A; Voneki, B; Vorobyev, A; Vorobyev, V; Voß, C; de Vries, J A; Vázquez Sierra, C; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wang, J; Ward, D R; Wark, H M; Watson, N K; Websdale, D; Weiden, A; Whitehead, M; Wicht, J; Wilkinson, G; Wilkinson, M; Williams, M; Williams, M P; Williams, M; Williams, T; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wraight, K; Wyllie, K; Xie, Y; Xing, Z; Xu, Z; Yang, Z; Yao, Y; Yin, H; Yu, J; Yuan, X; Yushchenko, O; Zarebski, K A; Zavertyaev, M; Zhang, L; Zhang, Y; Zhang, Y; Zhelezov, A; Zheng, Y; Zhu, X; Zhukov, V; Zucchelli, S

2017-05-12

The production of J/ψ mesons in jets is studied in the forward region of proton-proton collisions using data collected with the LHCb detector at a center-of-mass energy of 13 TeV. The fraction of the jet transverse momentum carried by the J/ψ meson, z(J/ψ)≡p_{T}(J/ψ)/p_{T}(jet), is measured using jets with p_{T}(jet)>20  GeV in the pseudorapidity range 2.5<η(jet)<4.0. The observed z(J/ψ) distribution for J/ψ mesons produced in b-hadron decays is consistent with expectations. However, the results for prompt J/ψ production do not agree with predictions based on fixed-order nonrelativistic QCD. This is the first measurement of the p_{T} fraction carried by prompt J/ψ mesons in jets at any experiment.

Pioneer 11 observations of trapped particle absorption by the Jovian ring and the satellites 1979, J1, J2, and J3

NASA Technical Reports Server (NTRS)

Pyle, K. R.; Mckibben, R. B.; Simpson, J. A.

1983-01-01

Pioneer 11 low energy telescope observation of charged particles around the Jovian satellites Amalthea, 1979 J1, J2, and J3, and the Jupiter ring are examined in the light of Voyager optical data from the same region. Good agreement was found in the absorption features of 0.5-8.7 MeV protons, electrons with energies of 3.4 MeV or more, and medium-Z nuclei. The heavier nuclei are suggested to be oxygen and sulfur particles with energies exceeding 70 MeV/nucleon. The observed intensity features in the regularly spaced radiation bands are interpreted as ring and satellite absorption.

A satellite relative motion model including J_2 and J_3 via Vinti's intermediary

NASA Astrophysics Data System (ADS)

Biria, Ashley D.; Russell, Ryan P.

2018-03-01

Vinti's potential is revisited for analytical propagation of the main satellite problem, this time in the context of relative motion. A particular version of Vinti's spheroidal method is chosen that is valid for arbitrary elliptical orbits, encapsulating J_2, J_3, and generally a partial J_4 in an orbit propagation theory without recourse to perturbation methods. As a child of Vinti's solution, the proposed relative motion model inherits these properties. Furthermore, the problem is solved in oblate spheroidal elements, leading to large regions of validity for the linearization approximation. After offering several enhancements to Vinti's solution, including boosts in accuracy and removal of some singularities, the proposed model is derived and subsequently reformulated so that Vinti's solution is piecewise differentiable. While the model is valid for the critical inclination and nonsingular in the element space, singularities remain in the linear transformation from Earth-centered inertial coordinates to spheroidal elements when the eccentricity is zero or for nearly equatorial orbits. The new state transition matrix is evaluated against numerical solutions including the J_2 through J_5 terms for a wide range of chief orbits and separation distances. The solution is also compared with side-by-side simulations of the original Gim-Alfriend state transition matrix, which considers the J_2 perturbation. Code for computing the resulting state transition matrix and associated reference frame and coordinate transformations is provided online as supplementary material.

The Re-Intensification of Typhoon Sinlaku (2008)

DTIC Science & Technology

2010-06-01

Tropical Cyclones, TCS-08, T- PARC , Extratropical Transition, Airborne Dual Doppler Radar , ELDORA, Axisymmetrization, Mesoscale Vortices, Mesoscale...observed by multiple aircraft as part of the TCS-08 and T- PARC field programs. Airborne dual-Doppler radar , dropwindsondes, and flight-level...typhoon southwest of Japan. The evolution of the tropical cyclone (TC) structure was observed by multiple aircraft as part of the TCS-08 and T- PARC

J-Plus Web Portal

NASA Astrophysics Data System (ADS)

Civera Lorenzo, Tamara

2017-10-01

Brief presentation about the J-PLUS EDR data access web portal (http://archive.cefca.es/catalogues/jplus-edr) where the different services available to retrieve images and catalogues data have been presented.J-PLUS Early Data Release (EDR) archive includes two types of data: images and dual and single catalogue data which include parameters measured from images. J-PLUS web portal offers catalogue data and images through several different online data access tools or services each suited to a particular need. The different services offered are: Coverage map Sky navigator Object visualization Image search Cone search Object list search Virtual observatory services: Simple Cone Search Simple Image Access Protocol Simple Spectral Access Protocol Table Access Protocol

Timothy J. Coutts | NREL

Science.gov Websites

conducting films of cadmium stannate: X. Wu, and T. J. Coutts (NREL IR#9545) PV devices comprising cadmium (NREL IR#9535) PV devices comprising zinc stannate buffer layer and method for making: X. Wu, P. Sheldon , and T. J. Coutts (NREL IR#9721) (filed) Publications View all NREL publications for Dr. Coutts. Awards

Promoting recovery via an integrated model of care to deliver a bed-based, mental health prevention and recovery centre.

PubMed

Lee, Stuart J; Collister, Laura; Stafrace, Simon; Crowther, Elizabeth; Kroschel, Jon; Kulkarni, Jayashri

2014-10-01

This research was conducted in order to explore the experience of care and outcomes for people entering a bed-based step-up/step-down Prevention and Recovery Centre (PARC). An audit of files for PARC participants in 2010 collected demographic (age, gender, and marital, housing, employment and education/training status) and clinical measures (length of stay, entry and exit outcome measures, psychiatric hospital use). Participants were also invited to a feedback group to discuss their PARC experience. In 2010, 118 people entered PARC. Most were single and unemployed and 35% were in temporary housing or homeless. In the six months following PARC exit, participants spent significantly less time in psychiatric hospital than in the six months prior to entry (p<0.001). Significant reductions in clinician-rated difficulties were documented at exit (p<0.001). For 40 episodes of care with self-report measures at entry and exit, significant reductions in difficulties with relating to self/others (p=0.004), daily living/role functioning (p=0.006), and depression/anxiety (p=0.019) were seen. Twelve participants attended a feedback group. Positive aspects of PARC included: supportive and caring staff; help with practical issues or community access; therapeutic activities and learning about health; and socialization opportunities. A step-up/step-down PARC can facilitate recovery for people with mental illness through promoting independence and illness self-management. © The Royal Australian and New Zealand College of Psychiatrists 2014.

Pea chloroplast DnaJ-J8 and Toc12 are encoded by the same gene and localized in the stroma.

PubMed

Chiu, Chi-Chou; Chen, Lih-Jen; Li, Hsou-min

2010-11-01

Toc12 is a novel J domain-containing protein identified in pea (Pisum sativum) chloroplasts. It was shown to be an integral outer membrane protein localizing in the intermembrane space of the chloroplast envelope. Furthermore, Toc12 was shown to associate with an intermembrane space Hsp70, suggesting that Toc12 is important for protein translocation across the chloroplast envelope. Toc12 shares a high degree of sequence similarity with Arabidopsis (Arabidopsis thaliana) DnaJ-J8, which has been suggested to be a soluble protein of the chloroplast stroma. Here, we isolated genes encoding DnaJ-J8 from pea and found that Toc12 is a truncated clone of one of the pea DnaJ-J8s. Protein import analyses indicate that Toc12 and DnaJ-J8s possess a cleavable transit peptide and are localized in the stroma. Arabidopsis mutants with T-DNA insertions in the DnaJ-J8 gene show no defect in chloroplast protein import. Implications of these results in the energetics and mechanisms of chloroplast protein import are discussed.

XTE J1946+274 = GRO J1944+26 Observations with RXTE and BATSE

NASA Technical Reports Server (NTRS)

Wilson, Colleen A.; Finger, Mark H.; Scott, D. Matthew

2000-01-01

XTE J1946+274 = GRO J1944+26 is a 15.8 second transient X-ray pulsar discovered simultaneously with the Rossi X-ray Timing Explorer (RXTE) and Burst and Transient Source Experiment (BATSE) onboard the Compton Gamma Ray Observatory (CGRO) during an outburst in September 1998. Since its discovery, XTE J1946+274 has undergone 7 regularly spaced outbursts, that were observed with BATSE and the RXTE All-Sky Monitor (ASM). The pulse frequency and pulsed flux measurements with BATSE suggest that XTE J1946+274 is in an about 170 day orbit and is outbursting twice per orbit. The first outburst, which was brighter and longer than subsequent outbursts, was also observed with the RXTE Proportional Counter Array (PCA). We present histories of pulse frequency, pulsed flux, and total flux measured in the 20-50 keV band with BATSE and a history of the 2-10 keV total flux measured with the RXTE ASM. From the first outburst, we present energy and power spectra and pulse profiles from RXTE PCA observations.

DEVELOPMENT OF HOME CAGE SOCIAL BEHAVIORS IN BALB/cJ vs. C57BL/6J MICE

PubMed Central

Fairless, Andrew H.; Katz, Julia M.; Vijayvargiya, Neha; Dow, Holly C.; Kreibich, Arati Sadalge; Berrettini, Wade H.; Abel, Ted; Brodkin, Edward S.

2012-01-01

BALB/cJ and C57BL/6J inbred mouse strains have been proposed as useful models of low and high levels of sociability (tendency to seek social interaction), respectively, based primarily on behaviors of ~30-day-old mice in the Social Approach Test (SAT). In the SAT, approach and sniffing behaviors of a test mouse toward an unfamiliar stimulus mouse are measured in a novel environment. However, it is unclear whether such results generalize to a familiar environment with a familiar social partner, such as with a littermate in a home cage environment. We hypothesized that C57BL/6J mice would show higher levels of social behaviors than BALB/cJ mice in the home cage environment, particularly at 30 days-of-age. We measured active and passive social behaviors in home cages by pairs of BALB/cJ or C57BL/6J littermates at ages 30, 41, and 69 days. The strains did not differ robustly in their active social behaviors. C57BL/6J mice were more passively social than BALB/cJ mice at 30 days, and C57BL/6J levels of passive social behaviors declined to BALB/cJ levels by 69 days. The differences in passive social behaviors at 30 days-of-age were primarily attributable to differences in huddling. These results indicate that different test conditions (SAT conditions vs. home cage conditions) elicit strain differences in distinct types of behaviors (approach/sniffing vs. huddling behaviors, respectively). Assessment of the more naturalistic social interactions in the familiar home cage environment with a familiar littermate will provide a useful component of a comprehensive assessment of social behaviors in mouse models relevant to autism. PMID:22982070

Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice.

PubMed

Fairless, Andrew H; Katz, Julia M; Vijayvargiya, Neha; Dow, Holly C; Kreibich, Arati Sadalge; Berrettini, Wade H; Abel, Ted; Brodkin, Edward S

2013-01-15

BALB/cJ and C57BL/6J inbred mouse strains have been proposed as useful models of low and high levels of sociability (tendency to seek social interaction), respectively, based primarily on behaviors of ∼30-day-old mice in the Social Approach Test (SAT). In the SAT, approach and sniffing behaviors of a test mouse toward an unfamiliar stimulus mouse are measured in a novel environment. However, it is unclear whether such results generalize to a familiar environment with a familiar social partner, such as with a littermate in a home cage environment. We hypothesized that C57BL/6J mice would show higher levels of social behaviors than BALB/cJ mice in the home cage environment, particularly at 30 days-of-age. We measured active and passive social behaviors in home cages by pairs of BALB/cJ or C57BL/6J littermates at ages 30, 41, and 69 days. The strains did not differ robustly in their active social behaviors. C57BL/6J mice were more passively social than BALB/cJ mice at 30 days, and C57BL/6J levels of passive social behaviors declined to BALB/cJ levels by 69 days. The differences in passive social behaviors at 30 days-of-age were primarily attributable to differences in huddling. These results indicate that different test conditions (SAT conditions vs. home cage conditions) elicit strain differences in distinct types of behaviors (approach/sniffing vs. huddling behaviors, respectively). Assessment of the more naturalistic social interactions in the familiar home cage environment with a familiar littermate will provide a useful component of a comprehensive assessment of social behaviors in mouse models relevant to autism. Copyright © 2012 Elsevier B.V. All rights reserved.

Theoretical study of homonuclear J coupling between quadrupolar spins: single-crystal, DOR, and J-resolved NMR.

PubMed

Perras, Frédéric A; Bryce, David L

2014-05-01

The theory describing homonuclear indirect nuclear spin-spin coupling (J) interactions between pairs of quadrupolar nuclei is outlined and supported by numerical calculations. The expected first-order multiplets for pairs of magnetically equivalent (A2), chemically equivalent (AA'), and non-equivalent (AX) quadrupolar nuclei are given. The various spectral changeovers from one first-order multiplet to another are investigated with numerical simulations using the SIMPSON program and the various thresholds defining each situation are given. The effects of chemical equivalence, as well as quadrupolar coupling, chemical shift differences, and dipolar coupling on double-rotation (DOR) and J-resolved NMR experiments for measuring homonuclear J coupling constants are investigated. The simulated J coupling multiplets under DOR conditions largely resemble the ideal multiplets predicted for single crystals, and a characteristic multiplet is expected for each of the A2, AA', and AX cases. The simulations demonstrate that it should be straightforward to distinguish between magnetic inequivalence and equivalence using J-resolved NMR, as was speculated previously. Additionally, it is shown that the second-order quadrupolar-dipolar cross-term does not affect the splittings in J-resolved experiments. Overall, the homonuclear J-resolved experiment for half-integer quadrupolar nuclei is demonstrated to be robust with respect to the effects of first- and second-order quadrupolar coupling, dipolar coupling, and chemical shift differences. Copyright © 2014 Elsevier Inc. All rights reserved.

Similarity of PSR J1906+0746 TO PSR J0737-3039: A Candidate of a New Double Pulsar System?

NASA Astrophysics Data System (ADS)

Yang, Yi-Yan; Zhang, Cheng-Min; Li, Di; Wang, De-Hua; Pan, Yuan-Yue; Lingfu, Rong-Feng; Zhou, Zhu-Wen

2017-02-01

PSR J1906+0746 is a nonrecycled strong magnetic field neutron star (NS), sharing the properties of the secondary-formed NS PSR J0737-3039B in the double pulsar system PSR J0737-3039AB. By comparing the orbital parameters of PSR J1906+0746 with those of PSR J0737-3039AB, we conclude that both systems have a similar origin and evolution history, involving an e-capture process for forming the second-born NS, like in the case of PSR J0737-3039B. We expect the companion of PSR J1906+0746 to be a long-lived recycled pulsar with radio beams that currently cannot be observed from Earth. We suggest possible ways to detect its presence. To compare PSR J1906+0746 with PSR J0737-3039, we also present the mass distribution of eight pairs of double NSs and find that in double NSs the mass of the recycled pulsar is usually larger than that of the nonrecycled one, which may be the result of accretion.

J-2X engine

NASA Image and Video Library

2012-04-20

NASA Administrator Charles Bolden (r) takes an up-close look at the first development J-2X rocket engine on the A-2 Test Stand at Stennis Space Center during an April 20, 2012, visit. Pictured with Bolden is A-2 Test Stand Director Skip Roberts. The J-2X engine is being developed for NASA by Pratt & Whitney Rocketdyne.

J-2X engine

NASA Image and Video Library

2012-04-20

NASA Administrator Charles Bolden (r) takes an up-close look at the first development J-2X rocket engine on the A-2 Test Stand at Stennis Space Center during an April 20, 2012, visit. Pictured with Bolden is A-2 Test Stand Director Skip Roberts. The J-2X engine i s being developed for NASA by Pratt & Whitney Rocketdyne.

Model-Independent Evidence for J/ψp Contributions to Λ_{b}^{0}→J/ψpK^{-} Decays.

PubMed

Aaij, R; Abellán Beteta, C; Adeva, B; Adinolfi, M; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; d'Argent, P; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baker, S; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Bel, L J; Bellee, V; Belloli, N; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bertolin, A; Betti, F; Bettler, M-O; van Beuzekom, M; Bifani, S; Billoir, P; Bird, T; Birnkraut, A; Bizzeti, A; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borgheresi, A; Borghi, S; Borisyak, M; Borsato, M; Boubdir, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britsch, M; Britton, T; Brodzicka, J; Buchanan, E; Burr, C; Bursche, A; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Campana, P; Campora Perez, D; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cavallero, G; Cenci, R; Charles, M; Charpentier, Ph; Chatzikonstantinidis, G; Chefdeville, M; Chen, S; Cheung, S-F; Chobanova, V; Chrzaszcz, M; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collazuol, G; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coquereau, S; Corti, G; Corvo, M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Dall'Occo, E; Dalseno, J; David, P N Y; Davis, A; De Aguiar Francisco, O; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Dean, C-T; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Demmer, M; Dendek, A; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Dijkstra, H; Dordei, F; Dorigo, M; Dosil Suárez, A; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Dungs, K; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Färber, C; Farley, N; Farry, S; Fay, R; Fazzini, D; Ferguson, D; Fernandez Albor, V; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fleuret, F; Fohl, K; Fontana, M; Fontanelli, F; Forshaw, D C; Forty, R; Frank, M; Frei, C; Frosini, M; Fu, J; Furfaro, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; García Pardiñas, J; Garra Tico, J; Garrido, L; Garsed, P J; Gascon, D; Gaspar, C; Gavardi, L; Gazzoni, G; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gotti, C; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Griffith, P; Grillo, L; Grünberg, O; Gushchin, E; Guz, Yu; Gys, T; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heister, A; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hongming, L; Hulsbergen, W; Humair, T; Hushchyn, M; Hussain, N; Hutchcroft, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jawahery, A; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kecke, M; Kelsey, M; Kenyon, I R; Kenzie, M; Ketel, T; Khairullin, E; Khanji, B; Khurewathanakul, C; Kirn, T; Klaver, S; Klimaszewski, K; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Kozeiha, M; Kravchuk, L; Kreplin, K; Kreps, M; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kurek, K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Lemaitre, F; Lemos Cid, E; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Likhomanenko, T; Lindner, R; Linn, C; Lionetto, F; Liu, B; Liu, X; Loh, D; Longstaff, I; Lopes, J H; Lucchesi, D; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusardi, N; Lusiani, A; Lyu, X; Machefert, F; Maciuc, F; Maev, O; Maguire, K; Malde, S; Malinin, A; Manca, G; Mancinelli, G; Manning, P; Mapelli, A; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marino, P; Marks, J; Martellotti, G; Martin, M; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massacrier, L M; Massafferri, A; Matev, R; Mathad, A; Mathe, Z; Matteuzzi, C; Mauri, A; Maurin, B; Mazurov, A; McCann, M; McCarthy, J; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Melnychuk, D; Merk, M; Merli, A; Michielin, E; Milanes, D A; Minard, M-N; Mitzel, D S; Molina Rodriguez, J; Monroy, I A; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Moron, J; Morris, A B; Mountain, R; Muheim, F; Mulder, M M; Müller, D; Müller, J; Müller, K; Müller, V; Mussini, M; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nandi, A; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, A D; Nguyen-Mau, C; Niess, V; Nieswand, S; Niet, R; Nikitin, N; Nikodem, T; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Ogilvy, S; Okhrimenko, O; Oldeman, R; Onderwater, C J G; Osorio Rodrigues, B; Otalora Goicochea, J M; Otto, A; Owen, P; Oyanguren, A; Palano, A; Palombo, F; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Pappalardo, L L; Pappenheimer, C; Parker, W; Parkes, C; Passaleva, G; Patel, G D; Patel, M; Patrignani, C; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perret, P; Pescatore, L; Petridis, K; Petrolini, A; Petruzzo, M; Picatoste Olloqui, E; Pietrzyk, B; Pikies, M; Pinci, D; Pistone, A; Piucci, A; Playfer, S; Plo Casasus, M; Poikela, T; Polci, F; Poluektov, A; Polyakov, I; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Price, E; Price, J D; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Quagliani, R; Rachwal, B; Rademacker, J H; Rama, M; Ramos Pernas, M; Rangel, M S; Raniuk, I; Raven, G; Redi, F; Reichert, S; Dos Reis, A C; Renaudin, V; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Robbe, P; Rodrigues, A B; Rodrigues, E; Rodriguez Lopez, J A; Rodriguez Perez, P; Rogozhnikov, A; Roiser, S; Romanovsky, V; Romero Vidal, A; Ronayne, J W; Rotondo, M; Ruf, T; Ruiz Valls, P; 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Sun, L; Sutcliffe, W; Swientek, K; Swientek, S; Syropoulos, V; Szczekowski, M; Szumlak, T; T'Jampens, S; Tayduganov, A; Tekampe, T; Tellarini, G; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Topp-Joergensen, S; Tournefier, E; Tourneur, S; Trabelsi, K; Traill, M; Tran, M T; Tresch, M; Trisovic, A; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vacca, C; Vagnoni, V; Valat, S; Valenti, G; Vallier, A; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; van Veghel, M; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vieites Diaz, M; Vilasis-Cardona, X; Volkov, V; Vollhardt, A; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; de Vries, J A; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wang, J; Ward, D R; Watson, N K; Websdale, D; Weiden, A; Whitehead, M; Wicht, J; Wilkinson, G; Wilkinson, M; Williams, M; Williams, M P; Williams, M; Williams, T; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wraight, K; Wright, S; Wyllie, K; Xie, Y; Xu, Z; Yang, Z; Yin, H; Yu, J; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, L; Zhang, Y; Zhelezov, A; Zheng, Y; Zhokhov, A; Zhong, L; Zhukov, V; Zucchelli, S

2016-08-19

The data sample of Λ_{b}^{0}→J/ψpK^{-} decays acquired with the LHCb detector from 7 and 8 TeV pp collisions, corresponding to an integrated luminosity of 3  fb^{-1}, is inspected for the presence of J/ψp or J/ψK^{-} contributions with minimal assumptions about K^{-}p contributions. It is demonstrated at more than nine standard deviations that Λ_{b}^{0}→J/ψpK^{-} decays cannot be described with K^{-}p contributions alone, and that J/ψp contributions play a dominant role in this incompatibility. These model-independent results support the previously obtained model-dependent evidence for P_{c}^{+}→J/ψp charmonium-pentaquark states in the same data sample.

Characterisation and molecular dynamic simulations of J15 asparaginase from Photobacterium sp. strain J15.

PubMed

Yaacob, Mohd Adilin; Hasan, Wan Atiqah Najiah Wan; Ali, Mohd Shukuri Mohamad; Rahman, Raja Noor Zaliha Raja Abdul; Salleh, Abu Bakar; Basri, Mahiran; Leow, Thean Chor

2014-01-01

Genome mining revealed a 1011 nucleotide-long fragment encoding a type I L-asparaginase (J15 asparaginase) from the halo-tolerant Photobacterium sp. strain J15. The gene was overexpressed in pET-32b (+) vector in E. coli strain Rosetta-gami B (DE3) pLysS and purified using two-step chromatographic methods: Ni(2+)-Sepharose affinity chromatography and Q-Sepharose anion exchange chromatography. The final specific activity and yield of the enzyme achieved from these steps were 20 U/mg and 49.2%, respectively. The functional dimeric form of J15-asparaginase was characterised with a molecular weight of ~70 kDa. The optimum temperature and pH were 25°C and pH 7.0, respectively. This protein was stable in the presence of 1 mM Ni(2+) and Mg(2+), but it was inhibited by Mn(2+), Fe(3+) and Zn(2+) at the same concentration. J15 asparaginase actively hydrolysed its native substrate, l-asparagine, but had low activity towards l-glutamine. The melting temperature of J15 asparaginase was ~51°C, which was determined using denatured protein analysis of CD spectra. The Km, Kcat, Kcat/Km of J15 asparaginase were 0.76 mM, 3.2 s(-1), and 4.21 s(-1) mM(-1), respectively. Conformational changes of the J15 asparaginase 3D structure at different temperatures (25°C, 45°C, and 65°C) were analysed using Molecular Dynamic simulations. From the analysis, residues Tyr₂₄ , His₂₂, Gly₂₃, Val₂₅ and Pro₂₆ may be directly involved in the 'open' and 'closed' lid-loop conformation, facilitating the conversion of substrates during enzymatic reactions. The properties of J15 asparaginase, which can work at physiological pH and has low glutaminase activity, suggest that this could be a good candidate for reducing toxic effects during cancer treatment.

J-2X engine assembly

NASA Image and Video Library

2011-03-03

Pratt & Whitney Rocketdyne employees Carlos Alfaro (l) and Oliver Swanier work on the main combustion element of the J-2X rocket engine at their John C. Stennis Space Center facility. Assembly of the J-2X rocket engine to be tested at the site is under way, with completion and delivery to the A-2 Test Stand set for June. The J-2X is being developed as a next-generation engine that can carry humans into deep space. Stennis Space Center is preparing a trio of stands to test the new engine.

Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains.

PubMed

Velez, Lady; Sokoloff, Greta; Miczek, Klaus A; Palmer, Abraham A; Dulawa, Stephanie C

2010-03-01

Some BALB/c substrains exhibit different levels of aggression. We compared aggression levels between male BALB/cJ and BALB/cByJ substrains using the resident intruder paradigm. These substrains were also assessed in other tests of emotionality and information processing including the open field, forced swim, fear conditioning, and prepulse inhibition tests. We also evaluated single nucleotide polymorphisms (SNPs) previously reported between these BALB/c substrains. Finally, we compared BALB/cJ and BALB/cByJ mice for genomic deletions or duplications, collectively termed copy number variants (CNVs), to identify candidate genes that might underlie the observed behavioral differences. BALB/cJ mice showed substantially higher aggression levels than BALB/cByJ mice; however, only minor differences in other behaviors were observed. None of the previously reported SNPs were verified. Eleven CNV regions were identified between the two BALB/c substrains. Our findings identify a robust difference in aggressive behavior between BALB/cJ and BALB/cByJ substrains, which could be the result of the identified CNVs.

High intensity single bunch operation with heavy periodic transient beam loading in wide band rf cavities

NASA Astrophysics Data System (ADS)

Tamura, Fumihiko; Hotchi, Hideaki; Schnase, Alexander; Yoshii, Masahito; Yamamoto, Masanobu; Ohmori, Chihiro; Nomura, Masahiro; Toda, Makoto; Shimada, Taihei; Hasegawa, Katsushi; Hara, Keigo

2015-09-01

The rapid cycling synchrotron (RCS) in the Japan Proton Accelerator Research Complex (J-PARC) was originally designed to accelerate two high intensity bunches, while some of neutron experiments in the materials and life science experimental facility and a muon experiment using main ring beams require a single bunch operation mode, in which one of the two rf buckets is filled and the other is empty. The beam intensity in the single bunch operation has been limited by longitudinal beam losses due to the rf bucket distortions by the wake voltage of the odd harmonics (h =1 ,3 ,5 ) in the wide band magnetic alloy cavities. We installed an additional rf feedforward system to compensate the wake voltages of the odd harmonics (h =1 ,3 ,5 ). The additional system has a similar structure as the existing feedforward system for the even harmonics (h =2 ,4 ,6 ). We describe the function of the feedforward system for the odd harmonics, the commissioning methodology, and the commissioning results. The longitudinal beam losses during the single bunch acceleration disappeared with feedforward for the odd harmonics. We also confirmed that the beam quality in the single bunch acceleration are similar to that of the normal operation with two bunches. Thus, high intensity single bunch acceleration at the intensity of 2.3 ×1013 protons per bunch has been achieved in the J-PARC RCS. This article is a follow-up of our previous article, Phys. Rev. ST Accel. Beams 14, 051004 (2011). The feedforward system extension for single bunch operation was successful.

Interesting experimental results in Japan Proton Accelerator Research Complex H{sup -} ion-source development (invited)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ueno, A.; Oguri, H.; Ikegami, K.

2010-02-15

The following interesting experimental results observed in Japan Proton Accelerator Research Complex (J-PARC) H{sup -} ion-source developments are reviewed. It was proven that almost all of H{sup -} ions were produced with surface reactions in cesium (Cs)-free J-PARC H{sup -} ion-sources. The world's most intense class H{sup -} ion current of 38 mA in Cs-free ion sources for a high-energy linac was attained by an optimal shape and high temperature of the plasma electrode (PE), usage of a lanthanum hexaboride (LaB{sub 6}) filament, and a newly devised high-power constant-current pulsed-arc power supply indispensable for it. It was also proven thatmore » the H{sup -} ion current could be increased to more than 40 mA by optimizing LaB{sub 6}-filament shape. The surface elemental analysis of the PE after operation with a LaB{sub 6}-filament showed that it was coated by boron (B) 95.5%, lanthanum (La) 2.5%, and oxygen (O) 1.9%. The H{sup -} ion current decreased by about 20% when a tungsten (W) filament was used instead of a LaB{sub 6}-filament. The H{sup -} ion current could not be increased by seeding cesium (Cs) if the LaB{sub 6}-filament was used. On the other hand, it was increased to more than 70 mA with much lower arc current of 150 A if Cs was seeded when a W-filament was used.« less

Multipartite quantum correlations in the extended J1-J2 Heisenberg model

NASA Astrophysics Data System (ADS)

Batle, J.; Tarawneh, O.; Nagata, Koji; Nakamura, Tadao; Abdalla, S.; Farouk, Ahmed

2017-11-01

Multipartite entanglement and the maximum violation of Bell inequalities are studied in finite clusters of spins in an extended J1-J2 Heisenberg model at zero temperature. The ensuing highly frustrated states will unveil a rich structure for different values of the corresponding spin-spin interaction strengths. The interplay between nearest-neighbors, next-nearest neighbors and further couplings will be explored using multipartite correlations. The model is relevant to certain quantum annealing computation architectures where an all-to-all connectivity is considered.

Overexpression of an ABC transporter and mutations of GyrA, GyrB, and ParC in contributing to high-level ciprofloxacin resistance in Streptococcus suis type 2.

PubMed

Yao, Jie; Shang, Kexin; Huang, Jinhu; Ran, Wei; Kashif, Jam; Wang, Liping

2014-04-01

Streptococcus suis is a pathogen of zoonotic diseases. Moreover, the emergence of fluoro-quinolones (FQs) resistance in this pathogen has severe consequences for pigs and human health. In this study, the molecular mechanism of FQs resistance in S. suis type 2 (SS2) sensitive strains isolated from pigs was assessed after in vitro induction of resistance against the most frequently used FQs: ciprofloxacin, norfloxacin, and enrofloxacin. Proteome analysis, sequencing and real-time RT-PCR results strongly established an overexpression of an ABC transporter protein (other than SatAB) and topoisomerase mutations in GyrA (Ser81Arg), GyrB (Glu354Lys), and ParC (Ser79Phe) in contributing to high level ciprofloxacin resistance in SS2. Due to the overexpression of the ABC transporter, intracellular ciprofloxacin concentrations were significantly lower in the resistant strains than those of sensitive strains after 20, 35, and 60 min exposures to ciprofloxacin (p < 0.05). It was concluded that improper use of FQs is one of the main causes of the emergence of this zoonotic pathogen as a multiresistant organism against commonly used antibiotics. The existence of an efflux-like protein is an incentive to find new drug targets to avoid the spread of FQs-resistant S. suis isolates in pigs and the human population.

Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations

PubMed Central

Kunz, Anjali N.; Begum, Afrin A.; Wu, Hong; D'Ambrozio, Jonathan A.; Robinson, James M.; Shafer, William M.; Bash, Margaret C.; Jerse, Ann E.

2012-01-01

Background. Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise from mutations in gyrA (intermediate resistance) or gyrA and parC (resistance). Here we tested the consequence of commonly isolated gyrA91/95 and parC86 mutations on gonococcal fitness. Methods. Mutant gyrA91/95 and parC86 alleles were introduced into wild-type gonococci or an isogenic mutant that is resistant to macrolides due to an mtrR−79 mutation. Wild-type and mutant bacteria were compared for growth in vitro and in competitive murine infection. Results. In vitro growth was reduced with increasing numbers of mutations. Interestingly, the gyrA91/95 mutation conferred an in vivo fitness benefit to wild-type and mtrR−79 mutant gonococci. The gyrA91/95, parC86 mutant, in contrast, showed a slight fitness defect in vivo, and the gyrA91/95, parC86, mtrR−79 mutant was markedly less fit relative to the parent strains. A ciprofloxacin-resistant (CipR) mutant was selected during infection with the gyrA91/95, parC86, mtrR−79 mutant in which the mtrR−79 mutation was repaired and the gyrA91 mutation was altered. This in vivo–selected mutant grew as well as the wild-type strain in vitro. Conclusions. gyrA91/95 mutations may contribute to the spread of QRNG. Further acquisition of a parC86 mutation abrogates this fitness advantage; however, compensatory mutations can occur that restore in vivo fitness and maintain CipR. PMID:22492860

Inclusive J / $$\\psi$$ Production at D0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murphy, Christopher R.

1995-04-01

We present results on inclusivemore » $$J/\\psi$$ and b-quark production in $$p\\bar{p}$$ collisions at $$\\sqrt{s}$$ = 1.8 TeV. The results are based on data collected at the D0 experiment during the 1992-1993 FermiLab collider run. There is excellent agreement between the differential $$J/\\psi$$ cross section measured at D0 and that measured at the CDF detector. A measurement of the fraction of $$J/\\psi$$ events due to b-quark decays is presented and we extract from this a measurement of the integrated b-quark cross section. The radiative decays of $$_{Xc}$$ charmonium states into the $$J/\\psi$$ is discussed and we present results on the fraction of $$J/\\psi$$ mesons that are due to $$_{Xc}$$ decays. We also observe that a fraction of promptly produced $$J/\\psi$$ mesons is larger than the measured fraction of $$J/\\psi$$ due to $$_{Xc}$$ decays and is not accounted for by existing charmonium. production models.« less

GeV Detection of HESS J0632+057

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Jian; Torres, Diego F.; Wilhelmi, Emma de Oña

2017-09-10

HESS J0632+057 is the only gamma-ray binary that has been detected at TeV energies, but not at GeV energies yet. Based on nearly nine years of Fermi Large Area Telescope (LAT) Pass 8 data, we report here on a deep search for the gamma-ray emission from HESS J0632+057 in the 0.1–300 GeV energy range. We find a previously unknown gamma-ray source, Fermi J0632.6+0548, spatially coincident with HESS J0632+057. The measured flux of Fermi J0632.6+0548 is consistent with the previous flux upper limit on HESS J0632+057 and shows variability that can be related to the HESS J0632+057 orbital phase. We proposemore » that Fermi J0632.6+0548 is the GeV counterpart of HESS J0632+057. Considering the Very High Energy spectrum of HESS J0632+057, a possible spectral turnover above 10 GeV may exist in Fermi J0632.6+0548, as appears to be common in other established gamma-ray binaries.« less

Spectrophotometry of J8, J9, and four Trojan asteroids from 0.32 to 1.05 microns

NASA Technical Reports Server (NTRS)

Smith, D. W.; Johnson, P. E.; Shorthill, R. W.

1981-01-01

New 30-channel narrowband photometry from 0.32 to 1.05 microns of the retrograde Jovian satellites J9 (to 0.7 micron) and J8 and the trailing Trojan asteroids 617, 884, 1172, and 1173 is presented. The data confirm previous measurements of J8, 617, 884, and 1172 at wavelengths less than 0.8 micron, but the extension into the infrared shows that the normalized spectral reflectance of these objects rises steadily from approximately 0.8 at 0.4 micron to approximately 1.4 at 1.05 microns, suggesting they are too bright in the near infrared to be C-type asteroids. The C classification of 1173 is confirmed. J9 is markedly redder than J8 at visible wavelengths. The results indicate a greater taxonomic contrast between these distant objects and main-belt asteroids than previously thought.

75 FR 18254 - R.J. Corman Railroad Company/Bardstown Line-Lease and Operation Exemption-R.J. Corman Railroad...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Finance Docket No. 35364] R.J. Corman Railroad Company/Bardstown Line--Lease and Operation Exemption--R.J. Corman Railroad Property, LLC R.J. Corman Railroad Company/Bardstown Line (RJC Railroad Company), a Class III rail carrier, has...

J Wave Syndromes: History and Current Controversies

PubMed Central

Liu, Tong; Zheng, Jifeng

2016-01-01

The concept of J wave syndromes was first proposed in 2004 by Yan et al for a spectrum of electrocardiographic (ECG) manifestations of prominent J waves that are associated with a potential to predispose affected individuals to ventricular fibrillation (VF). Although the concept of J wave syndromes is widely used and accepted, there has been tremendous debate over the definition of J wave, its ionic and cellular basis and arrhythmogenic mechanism. In this review article, we attempted to discuss the history from which the concept of J wave syndromes (JWS) is evolved and current controversies in JWS. PMID:27721848

Déjà Experiences in Temporal Lobe Epilepsy

PubMed Central

Illman, Nathan A.; Butler, Chris R.; Souchay, Celine; Moulin, Chris J. A.

2012-01-01

Historically, déjà vu has been linked to seizure activity in temporal lobe epilepsy, and clinical reports suggest that many patients experience the phenomenon as a manifestation of simple partial seizures. We review studies on déjà vu in epilepsy with reference to recent advances in the understanding of déjà vu from a cognitive and neuropsychological standpoint. We propose a decoupled familiarity hypothesis, whereby déjà vu is produced by an erroneous feeling of familiarity which is not in keeping with current cognitive processing. Our hypothesis converges on a parahippocampal dysfunction as the locus of déjà vu experiences. However, several other temporal lobe structures feature in reports of déjà vu in epilepsy. We suggest that some of the inconsistency in the literature derives from a poor classification of the various types of déjà experiences. We propose déjà vu/déjà vécu as one way of understanding déjà experiences more fully. This distinction is based on current models of memory function, where déjà vu is caused by erroneous familiarity and déjà vécu by erroneous recollection. Priorities for future research and clinical issues are discussed. PMID:22957231

Déjà experiences in temporal lobe epilepsy.

PubMed

Illman, Nathan A; Butler, Chris R; Souchay, Celine; Moulin, Chris J A

2012-01-01

Historically, déjà vu has been linked to seizure activity in temporal lobe epilepsy, and clinical reports suggest that many patients experience the phenomenon as a manifestation of simple partial seizures. We review studies on déjà vu in epilepsy with reference to recent advances in the understanding of déjà vu from a cognitive and neuropsychological standpoint. We propose a decoupled familiarity hypothesis, whereby déjà vu is produced by an erroneous feeling of familiarity which is not in keeping with current cognitive processing. Our hypothesis converges on a parahippocampal dysfunction as the locus of déjà vu experiences. However, several other temporal lobe structures feature in reports of déjà vu in epilepsy. We suggest that some of the inconsistency in the literature derives from a poor classification of the various types of déjà experiences. We propose déjà vu/déjà vécu as one way of understanding déjà experiences more fully. This distinction is based on current models of memory function, where déjà vu is caused by erroneous familiarity and déjà vécu by erroneous recollection. Priorities for future research and clinical issues are discussed.

Detection of J-coupling using atomic magnetometer

DOEpatents

Ledbetter, Micah P.; Crawford, Charles W.; Wemmer, David E.; Pines, Alexander; Knappe, Svenja; Kitching, John; Budker, Dmitry

2015-09-22

An embodiment of a method of detecting a J-coupling includes providing a polarized analyte adjacent to a vapor cell of an atomic magnetometer; and measuring one or more J-coupling parameters using the atomic magnetometer. According to an embodiment, measuring the one or more J-coupling parameters includes detecting a magnetic field created by the polarized analyte as the magnetic field evolves under a J-coupling interaction.

Correction of amplitude-phase distortion for polarimetric active radar calibrator

NASA Astrophysics Data System (ADS)

Lin, Jianzhi; Li, Weixing; Zhang, Yue; Chen, Zengping

2015-01-01

The polarimetric active radar calibrator (PARC) is extensively used as an external test target for system distortion compensation and polarimetric calibration for the high-resolution polarimetric radar. However, the signal undergoes distortion in the PARC, affecting the effectiveness of the compensation and the calibration. The system distortion compensation resulting from the distortion of the amplitude and phase in the PARC was analyzed based on the "method of paired echoes." Then the correction method was proposed, which separated the ideal signals from the distorted signals. Experiments were carried on real radar data, and the experimental results were in good agreement with the theoretical analysis. After the correction, the PARC can be better used as an external test target for the system distortion compensation.

Sequence stratigraphy and reservoir architecture of the J18/20 and J15 sequences in PM-9, Malay Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rahman, R.A.; Said, Md.J.; Bedingfield, J.R.

1994-07-01

The group J stratigraphic interval is lower Miocene (18.5-21 Ma) in age and was deposited during the early sag phase of the Malay Basin structural development. Reduction in depositional relief and first evidence of widespread marine influence characterize the transition into this interval. Twelve group J sequences have been identified. Reservoirs consist of progradational to aggradational tidally-dominated paralic to shallow marine sands deposited in the lowstand systems tract. Transgressive and highstand deposits are dominantly offshore shales. In PM-9, the original lift-related depocenters, coupled with changes in relative sea level, have strongly influenced group J unit thickness and the distribution ofmore » reservoir and seal facies. Two important reservoir intervals in PM-9 are the J18/20 and J15 sands. The reservoirs in these intervals are contained within the lowstand systems tracts of fourth-order sequences. These fourth-order sequences stack to form sequence sets in response to a third-order change in relative sea level. The sequences of the J18/20 interval stack to form part of a lowstand sequence set, whereas the J15 interval forms part of the transgressive sequence set. Reservoir facies range from tidal bars and subtidal shoals in the J18/20 interval to lower shoreface sands in the J15. Reservoir quality and continuity in group J reservoirs are dependent on depositional facies. An understanding of the controls on the distribution of facies types is crucial to the success of the current phase of field development and exploration programs in PM-9.« less

Development of time projection chamber for precise neutron lifetime measurement using pulsed cold neutron beams

NASA Astrophysics Data System (ADS)

Arimoto, Y.; Higashi, N.; Igarashi, Y.; Iwashita, Y.; Ino, T.; Katayama, R.; Kitaguchi, M.; Kitahara, R.; Matsumura, H.; Mishima, K.; Nagakura, N.; Oide, H.; Otono, H.; Sakakibara, R.; Shima, T.; Shimizu, H. M.; Sugino, T.; Sumi, N.; Sumino, H.; Taketani, K.; Tanaka, G.; Tanaka, M.; Tauchi, K.; Toyoda, A.; Tomita, T.; Yamada, T.; Yamashita, S.; Yokoyama, H.; Yoshioka, T.

2015-11-01

A new time projection chamber (TPC) was developed for neutron lifetime measurement using a pulsed cold neutron spallation source at the Japan Proton Accelerator Research Complex (J-PARC). Managing considerable background events from natural sources and the beam radioactivity is a challenging aspect of this measurement. To overcome this problem, the developed TPC has unprecedented features such as the use of polyether-ether-ketone plates in the support structure and internal surfaces covered with 6Li-enriched tiles to absorb outlier neutrons. In this paper, the design and performance of the new TPC are reported in detail.

Ethanol teratogenesis in the C57BL/6J, DBA/2J, and A/J inbred mouse strains.

PubMed

Boehm, S L; Lundahl, K R; Caldwell, J; Gilliam, D M

1997-01-01

Research has shown variations in susceptibility to alcohol-related birth defects in humans. Genetic differences are one reason for this variability. This study compared three inbred mouse strains to determine whether they differ in their susceptibilities to ethanol teratogenesis because previous studies have generated conflicting data. Pregnant C57BL/6J (B6), DBA/2J (D2), and A/J (A) dams were intubated intragastrically with either an acute dose of ethanol (5.8 g/kg) or an isocaloric amount of maltose-dextrine on day 9 of pregnancy. Litters were removed on day 18 of pregnancy and examined for gross, soft-tissue, and skeletal malformations. Results showed that ethanol-exposed B6 litters had a higher percentage of digit (19%), kidney (24%), and skeletal (32%, mostly vertebral) malformations than their maltose-exposed controls (7% or below). Prenatal exposure to ethanol increased skeletal (68%, both rib and vertebral) malformations for A litters when compared to their maltose-exposed controls (4%), but did not increase digit or kidney malformations. Ethanol-exposed D2 litters did not differ from maltose-exposed controls. Maternal blood ethanol levels did not differ among the B6, D2, and A strains. These results provide additional evidence suggesting a genetic component to ethanol teratogenesis.

j5 DNA assembly design automation.

PubMed

Hillson, Nathan J

2014-01-01

Modern standardized methodologies, described in detail in the previous chapters of this book, have enabled the software-automated design of optimized DNA construction protocols. This chapter describes how to design (combinatorial) scar-less DNA assembly protocols using the web-based software j5. j5 assists biomedical and biotechnological researchers construct DNA by automating the design of optimized protocols for flanking homology sequence as well as type IIS endonuclease-mediated DNA assembly methodologies. Unlike any other software tool available today, j5 designs scar-less combinatorial DNA assembly protocols, performs a cost-benefit analysis to identify which portions of an assembly process would be less expensive to outsource to a DNA synthesis service provider, and designs hierarchical DNA assembly strategies to mitigate anticipated poor assembly junction sequence performance. Software integrated with j5 add significant value to the j5 design process through graphical user-interface enhancement and downstream liquid-handling robotic laboratory automation.

The Spacelab J mission

NASA Technical Reports Server (NTRS)

Cremin, J. W.; Leslie, F. W.

1990-01-01

This paper describes Spacelab J (SL-J), its mission characteristics, features, parameters and configuration, the unique nature of the shared reimbursable cooperative effort with the National Space Development Agency (NASDA) of Japan and the evolution, content and objectives of the mission scientific experiment complement. The mission is planned for launch in 1991. This long module mission has 35 experiments from Japan as well as 9 investigations from the United States. The SL-J payload consists of two broad scientific disciplines which require the extended microgravity or cosmic ray environment: (1) materials science such as crystal growth, solidification processes, drop dynamics, free surface flows, gas dynamics, metallurgy and semiconductor technology; and (2) life science including cell development, human physiology, radiation-induced mutations, vestibular studies, embryo development, and medical technology. Through an international agreement with NASDA, NASA is preparing to fly the first Japanese manned, scientific, cooperative endeavor with the United States.

75 FR 20774 - Modification of Jet Routes J-37 and J-55; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-21

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010-0003; Airspace Docket No. 09-ANE-104] Modification of Jet Routes J-37 and J-55; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies Jet...

[Fluoroquinolone resistance mutations in topoisomerase genes of Salmonella typhimurium isolates].

PubMed

Guo, Yunchang; Pei, Xiaoyan; Liu, Xiumei

2004-09-01

Mutations in topoisomerase genes were main cause of the resistence of Salmonella typhimurium to fluoroquinolone. The MICs of three Salmonella typhimurium isolates X2, X7, X11 to ciprofloxacin were above 32 microg/ml, 0.38 microg/ml and 0.023 microg/ml, respectively. The genetic alterations in four topoisomerase genes, gyrA, gyrB, parC, and parE were detected by multiplex PCR amplimer conformation analysis in these three strains. X2 isolate showed both gyrA mutations (Ser83-->Phe, Asp87-->Asn) and parC mutation (Ser80-->Arg). X7 isolate showed a single gyrA mutation (Ser83-->Phe) and X11 isolate had no changes in all of the four quinolone resistance genes, gyrA, gyrB, parC, and parE. X7 isolate with a single gyrA mutation was less resistant to ciprofloxacin than X2 with double gyrA mutations and an additional parC mutation. GyrA and parC genes play important role of the resistance of Salmonella typhimurium to ciprofloxacin.

Déjà Vu: An Illusion of Prediction.

PubMed

Cleary, Anne M; Claxton, Alexander B

2018-04-01

Déjà vu is beginning to be scientifically understood as a memory phenomenon. Despite recent scientific advances, a remaining puzzle is the purported association between déjà vu and feelings of premonition. Building on research showing that déjà vu can be driven by an unrecalled memory of a past experience that relates to the current situation, we sought evidence of memory-based predictive ability during déjà vu states. Déjà vu did not lead to above-chance ability to predict the next turn in a navigational path resembling a previously experienced but unrecalled path (although such resemblance increased reports of déjà vu). However, déjà vu states were accompanied by increased feelings of knowing the direction of the next turn. The results suggest that feelings of premonition during déjà vu occur and can be illusory. Metacognitive bias brought on by the state itself may explain the peculiar association between déjà vu and the feeling of premonition.

Observation of J/psi-->3gamma.

PubMed

Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Reed, J; Briere, R A; Ferguson, T; Ma, J S Y; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hunt, J M; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Ledoux, J; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Libby, J; Powell, A; Wilkinson, G; Ecklund, K M; Love, W; Savinov, V; Mendez, H; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B

2008-09-05

We report the first observation of the decay J/psi-->3gamma. The signal has a statistical significance of 6sigma and corresponds to a branching fraction of B(J/psi-->3gamma)=(1.2+/-0.3+/-0.2)x10;{-5}, in which the errors are statistical and systematic, respectively. The measurement uses psi(2S)-->pi;{+}pi;{-}J/psi events acquired with the CLEO-c detector operating at the CESR e;{+}e;{-} collider.

Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ.

PubMed

Sittig, Laura J; Jeong, Choongwon; Tixier, Emily; Davis, Joe; Barrios-Camacho, Camila M; Palmer, Abraham A

2014-12-01

Closely related substrains of inbred mice often show phenotypic differences that are presumed to be caused by recent mutations. The substrains BALB/cJ and BALB/cByJ, which were separated in 1935, have been reported to show numerous highly significant behavioral and morphological differences. In an effort to identify some of the causal mutations, we phenotyped BALB/cJ and BALB/cByJ mice as well as their F1, F2, and N2 progeny for behavioral and morphological phenotypes. We also generated whole-genome sequence data for both inbred strains (~3.5× coverage) with the intention of identifying polymorphic markers to be used for linkage analysis. We observed significant differences in body weight, the weight of the heart, liver, spleen and brain, and corpus callosum length between the two substrains. We also observed that BALB/cJ animals showed greater anxiety-like behavior in the open field test, less depression-like behavior in the tail suspension test, and reduced aggression compared to BALB/cByJ mice. Some but not all of these physiological and behavioral results were inconsistent with prior publications. These inconsistencies led us to suspect that the differences were due to, or modified by, non-genetic factors. Thus, we did not perform linkage analysis. We provide a comprehensive summary of the prior literature about phenotypic differences between these substrains as well as our current findings. We conclude that many differences between these strains are unstable and therefore ill-suited to linkage analysis; the source of this instability is unclear. We discuss the broader implications of these observations for the design of future studies.

Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ

PubMed Central

Sittig, Laura J.; Jeong, Choongwon; Tixier, Emily; Davis, Joe; Barrios Camacho, Camila M.; Palmer, Abraham A.

2014-01-01

Closely related substrains of inbred mice often show phenotypic difzferences that are presumed to be caused by recent mutations. The substrains BALB/cJ and BALB/cByJ, which were separated in 1935, have been reported to show numerous highly significant behavioral and morphological differences. In an effort to identify some of the causal mutations, we phenotyped BALB/cJ and BALB/cByJ mice as well as their F1, F2, and N2 progeny for behavioral and morphological phenotypes. We also generated whole genome sequence data for both inbred strains (∼3.5× coverage) with the intention of identifying polymorphic markers to be used for linkage analysis. We observed significant differences in body weight, the weight of the heart, liver, spleen and brain, and corpus callosum length between the two substrains. We also observed that BALB/cJ animals showed greater anxiety-like behavior in the open field test, less depression-like behavior in the tail suspension test, and reduced aggression compared to BALB/cByJ mice. Some but not all of these physiological and behavioral results were inconsistent with prior publications. These inconsistencies led us to suspect that the differences were due to, or modified by, non-genetic factors. Thus, we did not perform linkage analysis. We provide a comprehensive summary of the prior literature about phenotypic differences between these substrains as well as our current findings. We conclude that many differences between these strains are unstable and therefore ill-suited to linkage analysis; the source of this instability is unclear. We discuss the broader implications of these observations for the design of future studies. PMID:24997021

Hemoglobin J-Korat in Thais.

PubMed

Blackwell, R Q; Blackwell, B N; Huang, J T; Chien, L C; Samaharn, A; Thephusdin, C; Borvornsin, C

1965-12-17

Hemoglobin J(Korat), a "fast" hemoglobin with an anomaly in its beta chain different from the anomalies previously reported, was the major hemoglobin component in the blood of nine subjects among 1923 Thais from northeastern Thailand. After hemoglobin E, J(Korat) is the second most frequent of the anomalous hemoglobins among Thais.

J-2X powerpack

NASA Image and Video Library

2012-10-05

NASA removed J-2X engine No. 10001 from the A-2 Test Stand at Stennis Space Center in early October. Opening of the test stand clamshell flooring allowed a clear view of the next-generation engine and stub nozzle, which is being built to help power future deep-space missions. The engine is an upgrade from the heritage J-2 rocket engine, which helped power Apollo missions to the moon during the late 1960s and early 1970s.

Pharmacodynamics of levofloxacin against characterized ciprofloxacin-resistant Streptococcus pneumoniae.

PubMed

Lister, Philip D

2008-09-01

In a previous study, levofloxacin 750 mg eradicated 4 ciprofloxacin-resistant isolates of Streptococcus pneumoniae from an in vitro pharmacodynamic model (IVPM). However, quinolone resistance-determining region (QRDR) mutations were not detected among those isolates. This study further evaluates levofloxacin 500 mg and 750 mg against S pneumoniae strains with characterized QRDR mutations. Six isolates with levofloxacin minimum inhibitory concentrations (MICs) of 2 to 4 microg/mL were selected for this study. Strains 5401, 5409, and 5437 contained only parC mutations. Three additional strains contained 2 mutations each: strain 5429 (parC and parE ), strain 5442 (parC and gyrA), and strain 5445 (parC and gyrB). Logarithmic-phase cultures (approximately 1 x 10(7) CFU/mL) were inoculated into the peripheral compartment of the IVPM and exposed to peak free-drug concentrations achieved with levofloxacin 500 mg and 750 mg (PO) and ciprofloxacin 750 mg (PO). Elimination pharmacokinetics were simulated and changes in viable counts were measured over 30 h. Ciprofloxacin exhibited very little antibacterial activity against the 6 strains, while levofloxacin 750 mg rapidly killed and eradicated the 3 parC mutant strains and the dual parC/parE mutant strains. Although levofloxacin 500 mg initially decreased viable counts by 4.5 to 6 logs, inoculum regrowth was observed between 12 and 24 h for the 6 strains. Regrowth was not due to the selection of mutant subpopulations. The pharmacodynamics of both levofloxacin doses were substantially diminished against the 2 strains with dual mutations in both parC and gyrA/B. The rapid eradication of single parC and dual parC/parE mutants with levofloxacin 750 mg demonstrates that this dose may slow the emergence of resistance due to these mutations. The decreased efficacy of both levofloxacin doses against the double parC and gyrA/B mutants highlights the importance of preventing the development and spread of double mutants.

Two American Entrepreneurs: Madame C. J. Walker and J. C. Penney. Teaching with Historic Places.

ERIC Educational Resources Information Center

Koman, Rita

2000-01-01

This lesson is based on the National Historic Landmark files, "Madame C. J. Walker Building" and "J. C. Penney Historic District," as well as other relevant sources. The lesson first discusses the Indianapolis (Indiana) site of Madame Walker's cosmetics business. The building is a 4-story brick structure completed in 1927.…

J / ψ Production and Polarization within a Jet

DOE PAGES

Kang, Zhong-Bo; Qiu, Jian-Wei; Ringer, Felix; ...

2017-07-18

We study the production and polarization of J/Ψ mesons within a jet in proton-proton collisions at the LHC. Here, we define the J/Ψ-jet fragmentation function as a ratio of differential jet cross sections with and without the reconstructed J/Ψ in the jet. We also demonstrate that this is a very useful observable to help explore the J/Ψ production mechanism, and to differentiate between different NRQCD global fits based on inclusive J/Ψ cross sections. Moreover, we propose to measure the polarization of J/Ψ mesons inside the jet, which can provide even more stringent constraints for the heavy quarkonium production mechanism.

J / ψ Production and Polarization within a Jet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kang, Zhong-Bo; Qiu, Jian-Wei; Ringer, Felix

We study the production and polarization of J/Ψ mesons within a jet in proton-proton collisions at the LHC. Here, we define the J/Ψ-jet fragmentation function as a ratio of differential jet cross sections with and without the reconstructed J/Ψ in the jet. We also demonstrate that this is a very useful observable to help explore the J/Ψ production mechanism, and to differentiate between different NRQCD global fits based on inclusive J/Ψ cross sections. Moreover, we propose to measure the polarization of J/Ψ mesons inside the jet, which can provide even more stringent constraints for the heavy quarkonium production mechanism.

Ribonucleases J1 and J2: two novel endoribonucleases in B.subtilis with functional homology to E.coli RNase E

PubMed Central

Even, Sergine; Pellegrini, Olivier; Zig, Lena; Labas, Valerie; Vinh, Joelle; Bréchemmier-Baey, Dominique; Putzer, Harald

2005-01-01

Many prokaryotic organisms lack an equivalent of RNase E, which plays a key role in mRNA degradation in Escherichia coli. In this paper, we report the purification and identification by mass spectrometry in Bacillus subtilis of two paralogous endoribonucleases, here named RNases J1 and J2, which share functional homologies with RNase E but no sequence similarity. Both enzymes are able to cleave the B.subtilis thrS leader at a site that can also be cleaved by E.coli RNase E. We have previously shown that cleavage at this site increases the stability of the downstream messenger. Moreover, RNases J1/J2 are sensitive to the 5′ phosphorylation state of the substrate in a site-specific manner. Orthologues of RNases J1/J2, which belong to the metallo-β-lactamase family, are evolutionarily conserved in many prokaryotic organisms, representing a new family of endoribonucleases. RNases J1/J2 appear to be implicated in regulatory processing/maturation of specific mRNAs, such as the T-box family members thrS and thrZ, but may also contribute to global mRNA degradation. PMID:15831787

J-2X Turbopump Cavitation Diagnostics

NASA Technical Reports Server (NTRS)

Santi, I. Michael; Butas, John P.; Tyler, Thomas R., Jr.; Aguilar, Robert; Sowers, T. Shane

2010-01-01

The J-2X is the upper stage engine currently being designed by Pratt & Whitney Rocketdyne (PWR) for the Ares I Crew Launch Vehicle (CLV). Propellant supply requirements for the J-2X are defined by the Ares Upper Stage to J-2X Interface Control Document (ICD). Supply conditions outside ICD defined start or run boxes can induce turbopump cavitation leading to interruption of J-2X propellant flow during hot fire operation. In severe cases, cavitation can lead to uncontained engine failure with the potential to cause a vehicle catastrophic event. Turbopump and engine system performance models supported by system design information and test data are required to predict existence, severity, and consequences of a cavitation event. A cavitation model for each of the J-2X fuel and oxidizer turbopumps was developed using data from pump water flow test facilities at Pratt & Whitney Rocketdyne (PWR) and Marshall Space Flight Center (MSFC) together with data from Powerpack 1A testing at Stennis Space Center (SSC) and from heritage systems. These component models were implemented within the PWR J-2X Real Time Model (RTM) to provide a foundation for predicting system level effects following turbopump cavitation. The RTM serves as a general failure simulation platform supporting estimation of J-2X redline system effectiveness. A study to compare cavitation induced conditions with component level structural limit thresholds throughout the engine was performed using the RTM. Results provided insight into system level turbopump cavitation effects and redline system effectiveness in preventing structural limit violations. A need to better understand structural limits and redline system failure mitigation potential in the event of fuel side cavitation was indicated. This paper examines study results, efforts to mature J-2X turbopump cavitation models and structural limits, and issues with engine redline detection of cavitation and the use of vehicle-side abort triggers to augment the

SoilJ - An ImageJ plugin for semi-automatized image-processing of 3-D X-ray images of soil columns

NASA Astrophysics Data System (ADS)

Koestel, John

2016-04-01

3-D X-ray imaging is a formidable tool for quantifying soil structural properties which are known to be extremely diverse. This diversity necessitates the collection of large sample sizes for adequately representing the spatial variability of soil structure at a specific sampling site. One important bottleneck of using X-ray imaging is however the large amount of time required by a trained specialist to process the image data which makes it difficult to process larger amounts of samples. The software SoilJ aims at removing this bottleneck by automatizing most of the required image processing steps needed to analyze image data of cylindrical soil columns. SoilJ is a plugin of the free Java-based image-processing software ImageJ. The plugin is designed to automatically process all images located with a designated folder. In a first step, SoilJ recognizes the outlines of the soil column upon which the column is rotated to an upright position and placed in the center of the canvas. Excess canvas is removed from the images. Then, SoilJ samples the grey values of the column material as well as the surrounding air in Z-direction. Assuming that the column material (mostly PVC of aluminium) exhibits a spatially constant density, these grey values serve as a proxy for the image illumination at a specific Z-coordinate. Together with the grey values of the air they are used to correct image illumination fluctuations which often occur along the axis of rotation during image acquisition. SoilJ includes also an algorithm for beam-hardening artefact removal and extended image segmentation options. Finally, SoilJ integrates the morphology analyses plugins of BoneJ (Doube et al., 2006, BoneJ Free and extensible bone image analysis in ImageJ. Bone 47: 1076-1079) and provides an ASCII file summarizing these measures for each investigated soil column, respectively. In the future it is planned to integrate SoilJ into FIJI, the maintained and updated edition of ImageJ with selected

The Natural Selection of the Chemical Elements (by R. J. P. Williams and J. J. R. Fraústo da Silva)

NASA Astrophysics Data System (ADS)

Kauffman, George B.

1998-12-01

Clarendon: New York, 1996. xxvi + 646 pp. Figs., tables. 20.5 x 25.6 cm. ISBN 0-19-855843-0. $80.00. R. J. P. Williams, Royal Society Research Professor Emeritus at Wadham College, Oxford University, and J. J. R. Fraústo da Silva, Professor of Analytical Chemistry at the Instituto Superior Técnico, Universidade Técnica de Lisboa, have collaborated on two previous volumes: New Trends in Bio-inorganic Chemistry (1978) and The Biological Chemistry of the Elements (3rd printing, 1994). Their latest collaborative effort is a book whose ambitious objective is "to show the relationship of every kind of material around us, living and nonliving, to the properties of the chemical elements of the periodic table." The "natural selection" of the chemical elements results from a number of factors, all of which are described in detail. Among these are chemical affinity related to the electronic configuration of their atoms, thermodynamic and kinetic stability, and "functional value to an organisation such as a living system". The physicist's approach to material through phase structure and the phase rule is stressed rather than the chemist's approach through bonding theories. The entire book possesses a strong environmental and interdisciplinary emphasis.

U (1 ) -symmetric infinite projected entangled-pair states study of the spin-1/2 square J1-J2 Heisenberg model

NASA Astrophysics Data System (ADS)

Haghshenas, R.; Sheng, D. N.

2018-05-01

We develop an improved variant of U (1 ) -symmetric infinite projected entangled-pair states (iPEPS) ansatz to investigate the ground-state phase diagram of the spin-1 /2 square J1-J2 Heisenberg model. In order to improve the accuracy of the ansatz, we discuss a simple strategy to select automatically relevant symmetric sectors and also introduce an optimization method to treat second-neighbor interactions more efficiently. We show that variational ground-state energies of the model obtained by the U (1 ) -symmetric iPEPS ansatz (for a fixed bond dimension D ) set a better upper bound, improving previous tensor-network-based results. By studying the finite-D scaling of the magnetically order parameter, we find a Néel phase for J2/J1<0.53 . For 0.53 <J2/J1<0.61 , a nonmagnetic columnar valence bond solid (VBS) state is established as observed by the pattern of local bond energy. The divergent behavior of correlation length ξ ˜D1.2 and vanishing order parameters are consistent with a deconfined Néel-to-VBS transition at J2c1/J1=0.530 (5 ) , where estimated critical anomalous exponents are ηs˜0.6 and ηd˜1.9 for spin and dimer correlations, respectively. We show that the associated VBS order parameter monotonically increases with J2/J1 and finally a first-order quantum phase transition takes place at J2c2/J1=0.610 (2 ) to the conventional Stripe phase. We compare our results with earlier DMRG and PEPS studies and suggest future directions for resolving remaining issues.

jFuzz: A Concolic Whitebox Fuzzer for Java

NASA Technical Reports Server (NTRS)

Jayaraman, Karthick; Harvison, David; Ganesh, Vijay; Kiezun, Adam

2009-01-01

We present jFuzz, a automatic testing tool for Java programs. jFuzz is a concolic whitebox fuzzer, built on the NASA Java PathFinder, an explicit-state Java model checker, and a framework for developing reliability and analysis tools for Java. Starting from a seed input, jFuzz automatically and systematically generates inputs that exercise new program paths. jFuzz uses a combination of concrete and symbolic execution, and constraint solving. Time spent on solving constraints can be significant. We implemented several well-known optimizations and name-independent caching, which aggressively normalizes the constraints to reduce the number of calls to the constraint solver. We present preliminary results due to the optimizations, and demonstrate the effectiveness of jFuzz in creating good test inputs. The source code of jFuzz is available as part of the NASA Java PathFinder. jFuzz is intended to be a research testbed for investigating new testing and analysis techniques based on concrete and symbolic execution. The source code of jFuzz is available as part of the NASA Java PathFinder.

J-2X engine test

NASA Image and Video Library

2011-12-01

NASA conducted a key stability test firing of the J-2X rocket engine on the A-2 Test Stand at Stennis Space Center on Dec. 1, marking another step forward in development of the upper-stage engine that will carry humans deeper into space than ever before. The J-2X will provide upper-stage power for NASA's new Space Launch System.

Interview with J. Michael Thompson

ERIC Educational Resources Information Center

Randall, Mary Elisabeth

2004-01-01

J. Michael Thompson is the Vice Provost for Enrollment Management and Dean of Admission and Financial Aid at the University of Southern California. J. Michael has worked in higher education for more than 30 years in a variety of roles at small private and mid-sized and large public universities, and now at USC, a large private university. He has…

CHANDRA OBSERVATIONS OF FIVE INTEGRAL SOURCES: NEW X-RAY POSITIONS FOR IGR J16393-4643 AND IGR J17091-3624

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bodaghee, A.; Tomsick, J. A.; Rahoui, F.

2012-06-01

The Chandra High Resolution Camera observed the fields of five hard X-ray sources in order to help us obtain X-ray coordinates with subarcsecond precision. These observations provide the most accurate X-ray positions known for IGR J16393-4643 and IGR J17091-3624. The obscured X-ray pulsar IGR J16393-4643 lies at R.A. (J2000) = 16{sup h}39{sup m}05.{sup s}47, and decl. = -46 Degree-Sign 42'13.''0 (error radius of 0.''6 at 90% confidence). This position is incompatible with the previously proposed counterpart 2MASS J16390535-4642137, and it points instead to a new counterpart candidate that is possibly blended with the Two Micron All Sky Survey star. Themore » black hole candidate IGR J17091-3624 was observed during its 2011 outburst providing coordinates of R.A. = 17{sup h}09{sup m}07.{sup s}59, and decl. = -36 Degree-Sign 24'25.''4. This position is compatible with those of the proposed optical/IR and radio counterparts, solidifying the source's status as a microquasar. Three targets, IGR J14043-6148, IGR J16358-4726, and IGR J17597-2201, were not detected. We obtained 3{sigma} upper limits of, respectively, 1.7, 1.8, and 1.5 Multiplication-Sign 10{sup -12} erg cm{sup -2} s{sup -1} on their 2-10 keV fluxes.« less

MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (MDA5) Signaling Pathway to Promote Avian Leukosis Virus Subgroup J (ALV-J)-Infected Cells Proliferaction and ALV-J Replication

PubMed Central

Li, Zhenhui; Luo, Qingbin; Xu, Haiping; Zheng, Ming; Abdalla, Bahareldin Ali; Feng, Min; Cai, Bolin; Zhang, Xiaocui; Nie, Qinghua; Zhang, Xiquan

2017-01-01

Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that has a similar replication cycle to multiple viruses and therefore can be used as a model system for viral entry into host cells. However, there are few reports on the genes or microRNAs (miRNAs) that are responsible for the replication of ALV-J. Our previous miRNA and RNA sequencing data showed that the expression of miR-34b-5p was significantly upregulated in ALV-J-infected chicken spleens compared to non-infected chicken spleens, but melanoma differentiation-associated gene 5 (MDA5) had the opposite expression pattern. In this study, a dual-luciferase reporter assay showed that MDA5 is a direct target of miR-34b-5p. In vitro, overexpression of miR-34b-5p accelerated the proliferation of ALV-J-infected cells by inducing the progression from G2 to S phase and it promoted cell migration. Ectopic expression of MDA5 inhibited ALV-J-infected cell proliferation, the cell cycle and cell migration, and knockdown of MDA5 promoted proliferation, the cell cycle and migration. In addition, during ALV-J infections, MDA5 can detect virus invasion and it triggers the MDA5 signaling pathway. MDA5 overexpression can activate the MDA5 signaling pathway, and thus it can inhibit the mRNA and protein expression of the ALV-J env gene and it can suppress virion secretion. In contrast, in response to the knockdown of MDA5 by small interfering RNA (siRNA) or an miR-34b-5p mimic, genes in the MDA5 signaling pathway were significantly downregulated (P < 0.05), but the mRNA and protein expression of ALV-J env and the sample-to-positive ratio of virion in the supernatants were increased. This indicates that miR-34b-5p is able to trigger the MDA5 signaling pathway and affect ALV-J infections. Together, these results suggest that miR-34b-5p targets MDA5 to accelerate the proliferation and migration of ALV-J-infected cells, and it promotes ALV-J replication, via the MDA5 signaling pathway. PMID:28194372

MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (MDA5) Signaling Pathway to Promote Avian Leukosis Virus Subgroup J (ALV-J)-Infected Cells Proliferaction and ALV-J Replication.

PubMed

Li, Zhenhui; Luo, Qingbin; Xu, Haiping; Zheng, Ming; Abdalla, Bahareldin Ali; Feng, Min; Cai, Bolin; Zhang, Xiaocui; Nie, Qinghua; Zhang, Xiquan

2017-01-01

Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that has a similar replication cycle to multiple viruses and therefore can be used as a model system for viral entry into host cells. However, there are few reports on the genes or microRNAs (miRNAs) that are responsible for the replication of ALV-J. Our previous miRNA and RNA sequencing data showed that the expression of miR-34b-5p was significantly upregulated in ALV-J-infected chicken spleens compared to non-infected chicken spleens, but melanoma differentiation-associated gene 5 ( MDA5 ) had the opposite expression pattern. In this study, a dual-luciferase reporter assay showed that MDA5 is a direct target of miR-34b-5p. In vitro , overexpression of miR-34b-5p accelerated the proliferation of ALV-J-infected cells by inducing the progression from G2 to S phase and it promoted cell migration. Ectopic expression of MDA5 inhibited ALV-J-infected cell proliferation, the cell cycle and cell migration, and knockdown of MDA5 promoted proliferation, the cell cycle and migration. In addition, during ALV-J infections, MDA5 can detect virus invasion and it triggers the MDA5 signaling pathway. MDA5 overexpression can activate the MDA5 signaling pathway, and thus it can inhibit the mRNA and protein expression of the ALV-J env gene and it can suppress virion secretion. In contrast, in response to the knockdown of MDA5 by small interfering RNA (siRNA) or an miR-34b-5p mimic, genes in the MDA5 signaling pathway were significantly downregulated ( P < 0.05), but the mRNA and protein expression of ALV-J env and the sample-to-positive ratio of virion in the supernatants were increased. This indicates that miR-34b-5p is able to trigger the MDA5 signaling pathway and affect ALV-J infections. Together, these results suggest that miR-34b-5p targets MDA5 to accelerate the proliferation and migration of ALV-J-infected cells, and it promotes ALV-J replication, via the MDA5 signaling pathway.

Ground-state ordering of the J1-J2 model on the simple cubic and body-centered cubic lattices

NASA Astrophysics Data System (ADS)

Farnell, D. J. J.; Götze, O.; Richter, J.

2016-06-01

The J1-J2 Heisenberg model is a "canonical" model in the field of quantum magnetism in order to study the interplay between frustration and quantum fluctuations as well as quantum phase transitions driven by frustration. Here we apply the coupled cluster method (CCM) to study the spin-half J1-J2 model with antiferromagnetic nearest-neighbor bonds J1>0 and next-nearest-neighbor bonds J2>0 for the simple cubic (sc) and body-centered cubic (bcc) lattices. In particular, we wish to study the ground-state ordering of these systems as a function of the frustration parameter p =z2J2/z1J1 , where z1 (z2) is the number of nearest (next-nearest) neighbors. We wish to determine the positions of the phase transitions using the CCM and we aim to resolve the nature of the phase transition points. We consider the ground-state energy, order parameters, spin-spin correlation functions, as well as the spin stiffness in order to determine the ground-state phase diagrams of these models. We find a direct first-order phase transition at a value of p =0.528 from a state of nearest-neighbor Néel order to next-nearest-neighbor Néel order for the bcc lattice. For the sc lattice the situation is more subtle. CCM results for the energy, the order parameter, the spin-spin correlation functions, and the spin stiffness indicate that there is no direct first-order transition between ground-state phases with magnetic long-range order, rather it is more likely that two phases with antiferromagnetic long range are separated by a narrow region of a spin-liquid-like quantum phase around p =0.55 . Thus the strong frustration present in the J1-J2 Heisenberg model on the sc lattice may open a window for an unconventional quantum ground state in this three-dimensional spin model.

IPHAS J025827.88+635234.9 and IPHAS J051814.33+294113.0: Two probable eclipsing intermediate polars

NASA Astrophysics Data System (ADS)

Joshi, Arti; Pandey, Jeewan Chandra

2018-04-01

We present photometry in the R-band and linear polarimetry of two cataclysmic variables, namely IPHAS J025827.88 + 635234.9 and IPHAS J051814.33 + 294113.0. The data were obtained from 1-m class tele-scopes of the Aryabhatta Research Institute of Observational Sciences (ARIES; Nainital, India). In addition to the deep eclipse, strong short-period oscillations are also found. We derived a pulse period of (1203 ± 25) s for IPHAS J025827.88 + 635234.9 and (3277 ± 81) s for IPHAS J051814.33 + 294113.0. The presence of both orbital and spin modulations in these systems indicate that they belong to a class of intermediate polars. The full width at half depth of the eclipse is also found to be variable from epoch to epoch for IPHAS J025827.88 + 635234.9. The presence of a variable linear polarization of high value in these two sources indicates that these systems possess a strong magnetic field.

75 FR 5704 - Proposed Modification of Jet Routes J-37 and J-55; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010-0003; Airspace Docket No. 09-ANE-104] RIN 2120-AA66 Proposed Modification of Jet Routes J-37 and J-55; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

J-Resistance Curves of Aluminum Specimens Using Moire Interferometry

DTIC Science & Technology

1989-04-01

elastic-plastic fracture mechanics ( EPFM ) methodologies are based on the J-integral or the crack opening displacement (COD) approach. The J-resistance curve...in the HRR field [13,141. In this paper, we present further application of the approximate J-evaluation procedure in large 2024-0 and 5052-H32 aluminum...Davis, J. A. Joyce, and R. A. Hays, " Application of the J-Integral and the Modified J-Integral to Cases of Large Crack Extension and High Toughness

Determination of the number of J/ψ events with inclusive J/ψ decays

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ai, X. C.; Albayrak, O.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, H. Y.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X.; Chen, X. R.; Chen, Y. B.; Cheng, H. P.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; De Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fan, J. Z.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Fedorov, O.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, X. Y.; Gao, Y.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, Y.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, Y.; Hussain, T.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. W.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kiese, P.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, J. C.; Li, Jin; Li, K.; Li, K.; Li, Lei; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. H.; Liu, H. H.; Liu, H. M.; Liu, J.; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqing; Loehner, H.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Santoro, V.; Sarantsev, A.; Savrié, M.; Schoenning, K.; Schumann, S.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Ullrich, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W.; Wang, W. P.; Wang, X. F.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, Z.; Xia, L.; Xia, L. G.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, W. L.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. N.; Zhang, Y. T.; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. W.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; BESIII Collaboration

2017-01-01

A measurement of the number of J/ψ events collected with the BESIII detector in 2009 and 2012 is performed using inclusive decays of the J/ψ. The number of J/ψ events taken in 2009 is recalculated to be (223.7 ± 1.4) × 106, which is in good agreement with the previous measurement, but with significantly improved precision due to improvements in the BESIII software. The number of J/ψ events taken in 2012 is determined to be (1086.9 ± 6.0) × 106. In total, the number of J/ψ events collected with the BESIII detector is measured to be (1310.6 ± 7.0) × 106, where the uncertainty is dominated by systematic effects and the statistical uncertainty is negligible. Supported by National Key Basic Research Program of China (2015CB856700), National Natural Science Foundation of China (NSFC) (10805053, 11125525, 11175188, 11235011, 11322544, 11335008, 11425524), Chinese Academy of Sciences (CAS) Large-Scale Scientific Facility Program, the CAS Center for Excellence in Particle Physics (CCEPP), Collaborative Innovation Center for Particles and Interactions (CICPI), Joint Large-Scale Scientific Facility Funds of NSFC and CAS (11179007, U1232201, U1232107, U1332201), CAS (KJCX2-YW-N29, KJCX2-YW-N45), 100 Talents Program of CAS, INPAC and Shanghai Key Laboratory for Particle Physics and Cosmology, German Research Foundation DFG (Collaborative Research Center CRC-1044), Istituto Nazionale di Fisica Nucleare, Italy; Ministry of Development of Turkey (DPT2006K-120470), Russian Foundation for Basic Research (14-07-91152), U. S. Department of Energy (DE-FG02-04ER41291, DE-FG02-05ER41374, DE-FG02-94ER40823, DESC0010118), U.S. National Science Foundation, University of Groningen (RuG) and the Helmholtzzentrum fuer Schwerionenforschung GmbH (GSI), Darmstadt; WCU Program of National Research Foundation of Korea (R32-2008-000-10155-0)

Large-scale neural networks and the lateralization of motivation and emotion.

PubMed

Tops, Mattie; Quirin, Markus; Boksem, Maarten A S; Koole, Sander L

2017-09-01

Several lines of research in animals and humans converge on the distinction between two basic large-scale brain networks of self-regulation, giving rise to predictive and reactive control systems (PARCS). Predictive (internally-driven) and reactive (externally-guided) control are supported by dorsal versus ventral corticolimbic systems, respectively. Based on extant empirical evidence, we demonstrate how the PARCS produce frontal laterality effects in emotion and motivation. In addition, we explain how this framework gives rise to individual differences in appraising and coping with challenges. PARCS theory integrates separate fields of research, such as research on the motivational correlates of affect, EEG frontal alpha power asymmetry and implicit affective priming effects on cardiovascular indicators of effort during cognitive task performance. Across these different paradigms, converging evidence points to a qualitative motivational division between, on the one hand, angry and happy emotions, and, on the other hand, sad and fearful emotions. PARCS suggests that those two pairs of emotions are associated with predictive and reactive control, respectively. PARCS theory may thus generate important new insights on the motivational and emotional dynamics that drive autonomic and homeostatic control processes. Copyright © 2017 Elsevier B.V. All rights reserved.

Application of an Improved Proteomics Method for Abundant Protein Cleanup: Molecular and Genomic Mechanisms Study in Plant Defense*

PubMed Central

Zhang, Yixiang; Gao, Peng; Xing, Zhuo; Jin, Shumei; Chen, Zhide; Liu, Lantao; Constantino, Nasie; Wang, Xinwang; Shi, Weibing; Yuan, Joshua S.; Dai, Susie Y.

2013-01-01

High abundance proteins like ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco) impose a consistent challenge for the whole proteome characterization using shot-gun proteomics. To address this challenge, we developed and evaluated Polyethyleneimine Assisted Rubisco Cleanup (PARC) as a new method by combining both abundant protein removal and fractionation. The new approach was applied to a plant insect interaction study to validate the platform and investigate mechanisms for plant defense against herbivorous insects. Our results indicated that PARC can effectively remove Rubisco, improve the protein identification, and discover almost three times more differentially regulated proteins. The significantly enhanced shot-gun proteomics performance was translated into in-depth proteomic and molecular mechanisms for plant insect interaction, where carbon re-distribution was used to play an essential role. Moreover, the transcriptomic validation also confirmed the reliability of PARC analysis. Finally, functional studies were carried out for two differentially regulated genes as revealed by PARC analysis. Insect resistance was induced by over-expressing either jacalin-like or cupin-like genes in rice. The results further highlighted that PARC can serve as an effective strategy for proteomics analysis and gene discovery. PMID:23943779

Decomposing racial and ethnic disparities in the use of postacute rehabilitation care.

PubMed

Holmes, George M; Freburger, Janet K; Ku, Li-Jung E

2012-06-01

To determine the degree to which racial and ethnic disparities in the use of postacute rehabilitation care (PARC) are explained by observed characteristics. State inpatient databases (SIDs) for 2005 and 2006 from four diverse states were used to identify patients with stays for joint replacement, stroke, or hip fracture. Our primary outcomes were use of institutional PARC (versus discharge home) and, conditional on discharge to an institution, skilled nursing facility (versus inpatient rehabilitation facility) care. We modified the Oaxaca-Blinder decomposition method to account for the dichotomous outcome and multilevel nature of the data. Discharges from the four SIDs were included if the principal diagnosis (stroke, hip fracture) or procedure (joint replacement) was in the sample inclusion criteria. Observed characteristics explained roughly half of the unadjusted differences in use of institutional PARC. Patient-level factors (clinical, age) were more explanatory of disparities in institutional PARC use, while hospital-level factors were more explanatory of skilled nursing facility versus inpatient rehabilitation facility care. Adjustment for characteristics influencing PARC use both mitigated and exacerbated racial/ethnic disparities in use. The degree to which the characteristics explained the disparity varied across conditions and outcomes. © Health Research and Educational Trust.

j5 v2.8.4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hillson, Nathan

j5 automates and optimizes the design of the molecular biological process of cloning/constructing DNA. j5 enables users to benefit from (combinatorial) multi-part scar-less SLIC, Gibson, CPEC, Golden Gate assembly, or variants thereof, for which automation software does not currently exist, without the intense labor currently associated with the process. j5 inputs a list of the DNA sequences to be assembled, along with a Genbank, FASTA, jbei-seq, or SBOL v1.1 format sequence file for each DNA source. Given the list of DNA sequences to be assembled, j5 first determines the cost-minimizing assembly strategy for each part (direct synthesis, PCR/SOE, or oligo-embedding),more » designs DNA oligos with Primer3, adds flanking homology sequences (SLIC, Gibson, and CPEC; optimized with Primer3 for CPEC) or optimized overhang sequences (Golden Gate) to the oligos and direct synthesis pieces, and utilizes BLAST to check against oligo mis-priming and assembly piece incompatibility events. After identifying DNA oligos that are already contained within a local collection for reuse, the program estimates the total cost of direct synthesis and new oligos to be ordered. In the instance that j5 identifies putative assembly piece incompatibilities (multiple pieces with high flanking sequence homology), the program suggests hierarchical subassemblies where possible. The program outputs a comma-separated value (CSV) file, viewable via Excel or other spreadsheet software, that contains assembly design information (such as the PCR/SOE reactions to perform, their anticipated sizes and sequences, etc.) as well as a properly annotated genbank file containing the sequence resulting from the assembly, and appends the local oligo library with the oligos to be ordered j5 condenses multiple independent assembly projects into 96-well format for high-throughput liquid-handling robotics platforms, and generates configuration files for the PR-PR biology-friendly robot programming language. j5 thus

Hypothalamic expression of Peg3 gene is associated with maternal care differences between SM/J and LG/J mouse strains

PubMed Central

Chiavegatto, Silvana; Sauce, Bruno; Ambar, Guilherme; Cheverud, James M; Peripato, Andrea C

2012-01-01

Maternal care is essential in mammals, and variations in the environment provided by mothers may directly influence the viability of newborns and emotional behavior later in life. A previous study investigated genetic variations associated with maternal care in an intercross of LG/J and SM/J inbred mouse strains and identified two single-locus QTLs (quantitative trait loci). Here, we selected three candidate genes located within these QTLs intervals; Oxt on chromosome 2, and FosB and Peg3 on chromosome 7 and tested their association with maternal care. LG/J females showed impaired postpartum nest building and pup retrieval, a one-day delay in milk ejection, reduced exploratory activity, and higher anxiety-like behavior when compared to SM/J females. The nucleotide sequences of Oxt and FosB were similar between strains, as were their hypothalamic expression levels. Conversely, Peg3 nucleotide sequences showed four nonsynonymous replacement substitutions on LG/J dams, T11062G, G13744A, A13808G, and G13813A, and a 30 base pair (10 aa) in tandem repeat in the coding region with three copies in SM/J and five copies in LG/J. Maternal care impaired LG/J mothers express 37% lower Peg3 mRNA levels in the hypothalamus on the second postpartum day. We also found an association of the Peg3 repeat-variant and poor maternal care in F2 heterozygote females derived from a LG/J × SM/J intercross. These results may suggest that the maternally imprinted Peg3 gene is responsible for the single-locus QTL on chromosome 7 that has been shown to influence maternal care in these strains. Furthermore, these data provide additional support for an epigenetic regulation of maternal behavior. PMID:22950040

Joint Chiefs of Staff > Directorates > J1 | Manpower and Personnel

Science.gov Websites

Management J1 | Manpower and Personnel J2 | Joint Staff Intelligence J3 | Operations J4 | Logistics► J8 | Force Structure, Resources & Assessment Contact J1 Manpower and Personnel Home : Directorates : J1 | Manpower and Personnel Mission To provide the Chairman of the Joint Chiefs of Staff

Dynamical structure factor of the J1-J2 Heisenberg model in one dimension: The variational Monte Carlo approach

NASA Astrophysics Data System (ADS)

Ferrari, Francesco; Parola, Alberto; Sorella, Sandro; Becca, Federico

2018-06-01

The dynamical spin structure factor is computed within a variational framework to study the one-dimensional J1-J2 Heisenberg model. Starting from Gutzwiller-projected fermionic wave functions, the low-energy spectrum is constructed from two-spinon excitations. The direct comparison with Lanczos calculations on small clusters demonstrates the excellent description of both gapless and gapped (dimerized) phases, including incommensurate structures for J2/J1>0.5 . Calculations on large clusters show how the intensity evolves when increasing the frustrating ratio and give an unprecedented accurate characterization of the dynamical properties of (nonintegrable) frustrated spin models.

J-2X engine

NASA Image and Video Library

2012-09-14

NASA engineers continued to collect test performance data on the new J-2X rocket engine at Stennis Space Center with a 250-second test Sept. 14. The test on the A-2 Test Stand was the 19th in a series of firings to gather critical data for continued development of the engine. The J-2X is being developed by Pratt and Whitney Rocketdyne for NASA's Marshall Space Flight Center in Huntsville, Ala. It is the first liquid oxygen and liquid hydrogen rocket engine rated to carry humans into space to be developed in 40 years.

Joint Chiefs of Staff > Directorates > J3 | Operations

Science.gov Websites

Joint Staff Structure Joint Staff Inspector General Origin of Joint Concepts U.S. Code | Joint Chiefs of J8 | Force Structure, Resources & Assessment Contact J3 Operations Home : Directorates : J3

Polarimetric SAR calibration experiment using active radar calibrators

NASA Astrophysics Data System (ADS)

Freeman, Anthony; Shen, Yuhsyen; Werner, Charles L.

1990-03-01

Active radar calibrators are used to derive both the amplitude and phase characteristics of a multichannel polarimetric SAR from the complex image data. Results are presented from an experiment carried out using the NASA/JPL DC-8 aircraft SAR over a calibration site at Goldstone, California. As part of the experiment, polarimetric active radar calibrators (PARCs) with adjustable polarization signatures were deployed. Experimental results demonstrate that the PARCs can be used to calibrate polarimetric SAR images successfully. Restrictions on the application of the PARC calibration procedure are discussed.

Polarimetric SAR calibration experiment using active radar calibrators

NASA Technical Reports Server (NTRS)

Freeman, Anthony; Shen, Yuhsyen; Werner, Charles L.

1990-01-01

Active radar calibrators are used to derive both the amplitude and phase characteristics of a multichannel polarimetric SAR from the complex image data. Results are presented from an experiment carried out using the NASA/JPL DC-8 aircraft SAR over a calibration site at Goldstone, California. As part of the experiment, polarimetric active radar calibrators (PARCs) with adjustable polarization signatures were deployed. Experimental results demonstrate that the PARCs can be used to calibrate polarimetric SAR images successfully. Restrictions on the application of the PARC calibration procedure are discussed.

Strain and sex differences in anxiety-like and social behaviors in C57BL/6J and BALB/cJ mice.

PubMed

An, Xiao-Lei; Zou, Jun-Xian; Wu, Rui-Yong; Yang, Ying; Tai, Fa-Dao; Zeng, Shuang-Yan; Jia, Rui; Zhang, Xia; Liu, En-Qi; Broders, Hugh

2011-01-01

Mood disorders are more frequent in women than men, however, the majority of research has focused on male rodents as animal models. We used a variety of common behavioral tests to look for differences in anxiety-like and social behaviors between and within C57BL/6J and BALB/cJ mice. Our results show that female C57BL/6J mice exhibited lower levels of anxiety-like behavior and higher levels of activity than female BALB/cJ during the open field and elevated plus maze tests. Principal component analysis generated more factors in the behavioral variables of males than females. In the open field, a sex difference was also found and factor 1 emerged as anxiety in males, and motor activity in females. While C57BL/6J mice were found to have higher levels of social exploration and social contacts, differences were found between the sexes (females were more social) in both strains for this measure and also for anxiety-like behaviors. When interacting with animals of the same sex, levels of sniffing body and huddling in both male and female C57BL/6J mice were higher than those in male and female BALB/cJ mice. However, in the between-sex interactions, male C57BL/6J mice sniffed the stimulus mouse less, and female C57BL/6J mice sniffed the stimulus more compared to BALB/cJ mice. This study provides important behavioral phenotypes and confirms the multidimensional behavioral structure of two widely used mice strains.

The J. Pedro Duret Mosquito Collection (Diptera: Culicidae)

DTIC Science & Technology

1990-12-01

and a consultant for the Pan American Health Organiza- tion. The labels and collection records associated with the specimens bear ecological and...19 9 Holotype male: ൚.VII.64/Brasil/ Amazonas /J. Gou- lard/rio Preto/Col. DURET/[underside of label] 2275 / jHOLOTIPO//2275//Culex (Anoediop...Melanoconion). Holotype male: ൤.VI.63/Brasil/ Amazonas /Manaos/Col. Duret/ [undersideoflabel] 1940//HOLOTIPO//1940//Culex (Melanoc.)/faurani sp. n.jJ.P

30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Electric Motor...

Apolipoprotein J (clusterin) and Alzheimer's disease.

PubMed

Calero, M; Rostagno, A; Matsubara, E; Zlokovic, B; Frangione, B; Ghiso, J

2000-08-15

Apolipoprotein J (clusterin) is a ubiquitous multifunctional glycoprotein capable of interacting with a broad spectrum of molecules. In pathological conditions, it is an amyloid associated protein, co-localizing with fibrillar deposits in systemic and localized amyloid disorders. In Alzheimer's disease, the most frequent form of amyloidosis in humans and the major cause of dementia in the elderly, apoJ is present in amyloid plaques and cerebrovascular deposits but is rarely seen in NFT-containing neurons. ApoJ expression is up-regulated in a wide variety of insults and may represent a defense response against local damage to neurons. Four different mechanisms of action could be postulated to explain the role of apoJ as a neuroprotectant during cellular stress: (1) function as an anti-apoptotic signal, (2) protection against oxidative stress, (3) inhibition of the membrane attack complex of complement proteins locally activated as a result of inflammation, and (4) binding to hydrophobic regions of partially unfolded, stressed proteins, and therefore avoiding aggregation in a chaperone-like manner. This review focuses on the association of apoJ in biological fluids with Alzheimer's soluble Abeta. This interaction prevents Abeta aggregation and fibrillization and modulates its blood-brain barrier transport at the cerebrovascular endothelium. Copyright 2000 Wiley-Liss, Inc.

The branching fraction calculations of Bc+ → ψ(2S)π+, Bc+ → J/ψK+ and Bc+ → J/ψDs+ decays relative to that of the Bc+ → J/ψπ+ mode

NASA Astrophysics Data System (ADS)

Mohammadi, Behnam

2018-03-01

The weak decay of Bc+ into ψ(2S)π+, J/ψK+ and J/ψDs+ mesons, observed by LHCb collaboration for the first time, are calculated in the model which takes into account the “factorizable” contributions and “nonfactorizable” corrections. The decays of Bc+ mesons into charmonia and light hadrons are expected to be well described by the factorization approximation. In the standard model, Bc+ → ψ(2S)π+, J/ψK+ decays occur through only the tree-level diagrams and so there are no CP violation in these channels. The decay Bc+ → ψ(2S)π+ is expected to proceed mainly via a b¯ →c¯ud¯ transition because the Bc+ → J/ψπ+ decay has identical final state and similar event topology, where it is chosen as the relative branching fraction channel. The ratio of branching fractions ℬ(Bc+ → J/ψK+)/ℬ(B c+ → J/ψπ+) is of particular interest since the CKM matrix element is suppressed by a factor |Vus/Vud|2 ˜ 0.05, in which the Bc+ → J/ψK+ occur through b¯ →c¯us¯ transition, but the dominant amplitude of the decay Bc+ → J/ψπ+ is a b¯ →c¯ud¯ transition. The decay Bc+ → J/ψD s+ is examined by color-allowed, color-suppressed spectator and weak annihilation diagrams. The weak annihilation topology, in contrast to decays of other beauty hadrons, is not suppressed and can contribute significantly to the decay amplitude. Because of the Bc+ → ψ(2S)π+, Bc+ → J/ψK+ and Bc+ → J/ψD s+ branching fractions are calculated relative to the Bc+ → J/ψπ+ decay, this decay mode is estimated separately, the ratio between them are 0.327 ± 0.028, 0.074 ± 0.0057 and 3.257 ± 0.293, respectively, that are compatible with the experimental data.

Dalitz plot analyses of J /ψ →π+π-π0, J /ψ →K+K-π0, and J /ψ →Ks0K±π∓ produced via e+e- annihilation with initial-state radiation

NASA Astrophysics Data System (ADS)

Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Brown, D. N.; Kolomensky, Yu. G.; Fritsch, M.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Gary, J. W.; Long, O.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Kim, J.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Röhrken, M.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Smith, J. G.; Wagner, S. R.; Bernard, D.; Verderi, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rotondo, M.; Zallo, A.; Passaggio, S.; Patrignani, C.; Lacker, H. M.; Bhuyan, B.; Szczepaniak, A. P.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Ahmed, H.; Pennington, M. R.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Le Diberder, F.; Lutz, A. M.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Cowan, G.; Banerjee, Sw.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Robertson, S. H.; Dey, B.; Neri, N.; Palombo, F.; Cheaib, R.; Cremaldi, L.; Godang, R.; Summers, D. J.; Taras, P.; De Nardo, G.; Sciacca, C.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Honscheid, K.; Kass, R.; Gaz, A.; Margoni, M.; Posocco, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Calderini, G.; Chauveau, J.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Rossi, A.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Rama, M.; Rizzo, G.; Walsh, J. J.; Smith, A. J. S.; Anulli, F.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Pilloni, A.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Heß, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Wilson, F. F.; Emery, S.; Vasseur, G.; Aston, D.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Luitz, S.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Ratcliff, B. N.; Roodman, A.; Sullivan, M. K.; Va'vra, J.; Wisniewski, W. J.; Purohit, M. V.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Schwitters, R. F.; Izen, J. M.; Lou, X. C.; Bianchi, F.; De Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Albert, J.; Beaulieu, A.; Bernlochner, F. U.; King, G. J.; Kowalewski, R.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Prepost, R.; Wu, S. L.; BaBar Collaboration

2017-04-01

We study the processes e+e- →γISRJ /ψ , where J /ψ →π+π-π0, J /ψ →K+K-π0, and J /ψ →KS0K±π∓ using a data sample of 519 fb-1 recorded with the BABAR detector operating at the SLAC PEP-II asymmetric-energy e+e- collider at center-of-mass energies at and near the Υ (n S ) (n =2 ,3 ,4 ) resonances. We measure the ratio of branching fractions R1=B/(J /ψ →K+K-π0) B (J /ψ →π+π-π0) and R2=B/(J /ψ →KS0K±π∓) B (J /ψ →π+π-π0) . We perform Dalitz plot analyses of the three J /ψ decay modes and measure fractions for resonances contributing to the decays. We also analyze the J /ψ →π+π-π0 decay using the Veneziano model. We observe structures compatible with the presence of ρ (1450 ) in all three J /ψ decay modes and measure the relative branching fraction: R (ρ (1450 ))=B/(ρ (1450 )→K+K-) B (ρ (1450 )→π+π-) =0.307 ±0.084 (stat)±0.082 (sys).

First demonstration of an emulsion multi-stage shifter for accelerator neutrino experiments in J-PARC T60

NASA Astrophysics Data System (ADS)

Yamada, K.; Aoki, S.; Cao, S.; Chikuma, N.; Fukuda, T.; Fukuzawa, Y.; Gonin, M.; Hayashino, T.; Hayato, Y.; Hiramoto, A.; Hosomi, F.; Inoh, T.; Iori, S.; Ishiguro, K.; Kawahara, H.; Kim, H.; Kitagawa, N.; Koga, T.; Komatani, R.; Komatsu, M.; Matsushita, A.; Mikado, S.; Minamino, A.; Mizusawa, H.; Matsumoto, T.; Matsuo, T.; Morimoto, Y.; Morishima, K.; Morishita, M.; Naganawa, N.; Nakamura, K.; Nakamura, M.; Nakamura, Y.; Nakano, T.; Nakatsuka, Y.; Nakaya, T.; Nishio, A.; Ogawa, S.; Oshima, H.; Quilain, B.; Rokujo, H.; Sato, O.; Seiya, Y.; Shibuya, H.; Shiraishi, T.; Suzuki, Y.; Tada, S.; Takahashi, S.; Yokoyama, M.; Yoshimoto, M.

2017-06-01

We describe the first ever implementation of a clock-based, multi-stage emulsion shifter in an accelerator neutrino experiment. The system was installed in the neutrino monitoring building at the Japan Proton Accelerator Research Complex as part of a test experiment, T60, and stable operation was maintained for a total of 126.6 days. By applying time information to emulsion films, various results were obtained. Time resolutions of 5.3-14.7 s were evaluated in an operation spanning 46.9 days (yielding division numbers of 1.4-3.8×105). By using timing and spatial information, reconstruction of coincident events consisting of high-multiplicity and vertex-contained events, including neutrino events, was performed. Emulsion events were matched to events observed by INGRID, one of the on-axis near detectors of the T2K experiment, with high reliability (98.5%), and hybrid analysis of the emulsion and INGRID events was established by means of the multi-stage shifter. The results demonstrate that the multi-stage shifter can feasibly be used in neutrino experiments.

Numerical study of incommensurate and decoupled phases of spin-1/2 chains with isotropic exchange J 1, J 2 between first and second neighbors

NASA Astrophysics Data System (ADS)

Soos, Zoltán G.; Parvej, Aslam; Kumar, Manoranjan

2016-05-01

The spin-1/2 chain with isotropic exchange J 1, J 2  >  0 between first and second neighbors is frustrated for either sign of J 1 and has a singlet ground state (GS) for J 1/J 2  ⩾  -4. Its rich quantum phase diagram supports gapless, gapped, commensurate (C), incommensurate (IC) and other phases. Critical points J 1/J 2 are evaluated using exact diagonalization and density matrix renormalization group calculations. The wave vector q G of spin correlations is related to GS degeneracy and obtained as the peak of the spin structure factor S(q). Variable q G indicates IC phases in two J 1/J 2 intervals, [-4, -  1.24] and [0.44, 2], and a C-IC point at J 1/J 2  =  2. The decoupled C phase in [-1.24, 0.44] has constant q G  =  π/2, nondegenerate GS, and a lowest triplet state with broken spin density on sublattices of odd and even numbered sites. The lowest triplet and singlet excitations, E m and E σ , are degenerate in finite systems at specific frustration J 1/J 2. Level crossing extrapolates in the thermodynamic limit to the same critical points as q G. The S(q) peak diverges at q G  =  π in the gapless phase with J 1/J 2  >  4.148 and quasi-long-range order (QLRO(π)). S(q) diverges at  ±π/2 in the decoupled phase with QLRO(π/2), but is finite in gapped phases with finite-range correlations. Numerical results and field theory agree at small J 2/J 1 but disagree for the decoupled phase with weak exchange J 1 between sublattices. Two related models are summarized: one has an exact gapless decoupled phase with QLRO(π/2) and no IC phases; the other has a single IC phase without a decoupled phase in between.

STS-47 Spacelab-J, Onboard Photograph

NASA Technical Reports Server (NTRS)

1992-01-01

Japanese astronaut, Mamoru Mohri, talks to Japanese students from the aft flight deck of the Space Shuttle Orbiter Endeavour during the Spacelab-J (SL-J) mission. The SL-J mission was a joint venture between NASA and the National Space Development Agency of Japan (NASDA) utilizing a marned Spacelab module. The mission conducted 24 materials science and 20 life science experiments, of which 35 were sponsored by NASDA, 7 by NASA, and two collaborative efforts. Materials science investigations covered such fields as biotechnology, electronic materials, fluid dynamics and transport phenomena, glasses and ceramics, metals and alloys, and acceleration measurements. Life sciences included experiments on human health, cell separation and biology, developmental biology, animal and human physiology and behavior, space radiation, and biological rhythms. Test subjects included the crew, Japanese koi fish (carp), cultured animal and plant cells, chicken embryos, fruit flies, fungi and plant seeds, and frogs and frog eggs. Spacelab-J was launched aboard the Space Shuttle Orbiter Endeavour on September 12, 1992.

Global analysis of DNA methylation in young (J1) and senescent (J2) Gossypium hirsutum L. cotyledons by MeDIP-Seq

PubMed Central

Dou, Lingling; Jia, Xiaoyun; Wei, Hengling; Fan, Shuli; Wang, Hantao; Guo, Yaning; Duan, Shan; Pang, Chaoyou; Yu, Shuxun

2017-01-01

DNA methylation is an important epigenetic modification regulating gene expression, genomic imprinting, transposon silencing and chromatin structure in plants and plays an important role in leaf senescence. However, the DNA methylation pattern during Gossypium hirsutum L. cotyledon senescence is poorly understood. In this study, global DNA methylation patterns were compared between two cotyledon development stages, young (J1) and senescence (J2), using methylated DNA immunoprecipitation (MeDIP-Seq). Methylated cytosine occurred mostly in repeat elements, especially LTR/Gypsy in both J1 and J2. When comparing J1 against J2, there were 1222 down-methylated genes and 623 up-methylated genes. Methylated genes were significantly enriched in carbohydrate metabolism, biosynthesis of other secondary metabolites and amino acid metabolism pathways. The global DNA methylation level decreased from J1 to J2, especially in gene promoters, transcriptional termination regions and regions around CpG islands. We further investigated the expression patterns of 9 DNA methyltransferase-associated genes and 2 DNA demethyltransferase-associated genes from young to senescent cotyledons, which were down-regulated during cotyledon development. In this paper, we first reported that senescent cotton cotyledons exhibited lower DNA methylation levels, primarily due to decreased DNA methyltransferase activity and which also play important role in regulating secondary metabolite process. PMID:28715427

Energy metabolism in BPH/2J genetically hypertensive mice.

PubMed

Jackson, Kristy L; Nguyen-Huu, Thu-Phuc; Davern, Pamela J; Head, Geoffrey A

2014-05-01

Recent evidence indicates that genetic hypertension in BPH/2J mice is sympathetically mediated, but these mice also have lower body weight (BW) and elevated locomotor activity compared with BPN/3J normotensive mice, suggestive of metabolic abnormalities. The aim of the present study was to determine whether hypertension in BPH/2J mice is associated with metabolic differences. Whole-body metabolic and cardiovascular parameters were measured over 24 h by indirect calorimetry and radiotelemetry respectively, in conscious young (10-13 weeks) and older (22-23 weeks) BPH/2J, normotensive BPN/3J and C57Bl6 mice. Blood pressure (BP) was greater in BPH/2J compared with both normotensive strains at both ages (P<0.01). Metabolic rate was greater in young BPH/2J compared with BPN/3J mice (P<0.01) but similar to C57Bl6 mice indicating that high metabolic rate is not necessarily related to the hypertension per say. The slope of the BP-metabolic rate relationship was comparable between BPH/2J and normotensive mice when adjusted for activity (P>0.1) suggesting differences in this relationship are not responsible for hypertension. EchoMRI revealed that percentage body composition was comparable in BPN/3J and BPH/2J mice (P>0.1) and both strains gained weight similarly with age (P=0.3). Taken together, the present findings indicate that hypertension in BPH/2J mice does not appear to be related to altered energy metabolism.

Branching fraction measurement of J / ψ → K S K L and search for J / ψ → K S K S

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2017-12-04

Using a sample of 1.31×10 9J/ψ events collected with the BESIII detector at the BEPCII collider, we study the decays of J/ψ→ K SK L and K SK S. The branching fraction of J/ψ→ K SK L is determined to be B(J/ψ→ K SK L) = (1:93 0:01 (stat:) 0:05 (syst:))×10 -4, which signi cantly improves on previous measurements. No clear signal is observed for the J/ψ→ K SK S process, and the upper limit at the 95% con dence level for its branching fraction is determined to be B(J= ! K SK S) < 1:4×10 -8, which improves onmore » the previous searches by 2 orders in magnitude and reaches the order of the Einstein-Podolsky-Rosen expectation.« less

Branching fraction measurement of J / ψ → K S K L and search for J / ψ → K S K S

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

Using a sample of 1.31×10 9J/ψ events collected with the BESIII detector at the BEPCII collider, we study the decays of J/ψ→ K SK L and K SK S. The branching fraction of J/ψ→ K SK L is determined to be B(J/ψ→ K SK L) = (1:93 0:01 (stat:) 0:05 (syst:))×10 -4, which signi cantly improves on previous measurements. No clear signal is observed for the J/ψ→ K SK S process, and the upper limit at the 95% con dence level for its branching fraction is determined to be B(J= ! K SK S) < 1:4×10 -8, which improves onmore » the previous searches by 2 orders in magnitude and reaches the order of the Einstein-Podolsky-Rosen expectation.« less

Richard J. French, Ph.D. | NREL

Science.gov Websites

J. French, Ph.D. Photo of Richard J. French Rick French Researcher IV-Chemistry Richard.French Laboratory equipment design and construction Computer-aided design (CAD) Education Ph.D., Chemistry, Oregon State University B.S., Chemistry, Wheaton College Professional Experience Research Scientist, National

Numerical analysis and experiment to identify origin of buckling in rapid cycling synchrotron core

NASA Astrophysics Data System (ADS)

Morita, Y.; Kageyama, T.; Akoshima, M.; Torizuka, S.; Tsukamoto, M.; Yamashita, S.; Yoshikawa, N.

2013-11-01

The accelerating cavities used in the rapid cycling synchrotron (RCS) of the Japan Proton Accelerator Research Complex (J-PARC) are loaded with magnetic alloy (MA) cores. Over lengthly periods of RCS operation, significant reductions in the impedance of the cavities resulting from the buckling of the cores were observed. A series of thermal structural simulations and compressive strength tests showed that the buckling can be attributed to the low-viscosity epoxy resin impregnation of the MA core that causes the stiffening of the originally flexible MA-ribbon-wound core. Our results showed that thermal stress can be effectively reduced upon using a core that is not epoxy-impregnated.

STS-47 Spacelab-J, Onboard Photograph

NASA Technical Reports Server (NTRS)

1992-01-01

The Spacelab-J (SL-J) mission was a joint venture between NASA and the National Space Development Agency of Japan (NASDA) utilizing a marned Spacelab module. Materials science investigations covered such fields as biotechnology, electronic materials, fluid dynamics and transport phenomena, glasses and ceramics, metals and alloys, and acceleration measurements. Life sciences included experiments on human health, cell separation and biology, developmental biology, animal and human physiology and behavior, space radiation, and biological rhythms. Before long-term space ventures are attempted, numerous questions must be answered: how will gravity play in the early development of an organism, and how will new generations of a species be conceived and develop normally in microgravity. The Effects of Weightlessness on the Development of Amphibian Eggs Fertilized in Space experiment aboard SL-J examined aspects of these questions. To investigate the effect of microgravity on amphibian development, female frogs carried aboard SL-J were induced to ovulate and shed eggs. These eggs were then fertilized in the microgravity environment. Half were incubated in microgravity, while the other half were incubated in a centrifuge that spins to simulate normal gravity. This photograph shows an astronaut working with one of the adult female frogs inside the incubator. The mission also examined the swimming behavior of tadpoles grown in the absence of gravity. The Spacelab-J was launched aboard the Space Shuttle Orbiter Endeavour on September 12, 1992.

Fermi LAT Detection of Pulsed Gamma-Rays From the Vela-Like Pulsars PSR J1048-5832 and PSR J2229+6114

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, A.A.; /Naval Research Lab, Wash., D.C. /Federal City Coll.; Ackermann, M.

We report the detection of {gamma}-ray pulsations ({ge}0.1 GeV) from PSR J2229+6114 and PSR J1048-5832, the latter having been detected as a low-significance pulsar by EGRET. Data in the {gamma}-ray band were acquired by the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope, while the radio rotational ephemerides used to fold the {gamma}-ray light curves were obtained using the Green Bank Telescope, the Lovell telescope at Jodrell Bank, and the Parkes Telescope. The two young radio pulsars, located within the error circles of the previously unidentified EGRET sources 3EG J1048-5840 and 3EG J2227+6122, present spin-down characteristics similar tomore » the Vela pulsar. PSR J1048-5832 shows two sharp peaks at phases 0.15 {+-} 0.01 and 0.57 {+-} 0.01 relative to the radio pulse confirming the EGRET light curve, while PSR J2229+6114 presents a very broad peak at phase 0.49 {+-} 0.01. The {gamma}-ray spectra above 0.1 GeV of both pulsars are fit with power laws having exponential cutoffs near 3 GeV, leading to integral photon fluxes of (2.19 {+-} 0.22 {+-} 0.32) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J1048-5832 and (3.77 {+-} 0.22 {+-} 0.44) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J2229+6114. The first uncertainty is statistical and the second is systematic. PSR J1048-5832 is one of the two LAT sources which were entangled together as 3EG J1048-5840. These detections add to the growing number of young {gamma}-ray pulsars that make up the dominant population of GeV {gamma}-ray sources in the Galactic plane.« less

Swift observation of Nova Ophiuchi 2018 No.2 = PNV J17140261-2849237 = TCP J17140253-2849233

NASA Astrophysics Data System (ADS)

Sokolovsky, K.

2018-03-01

The nova candidate PNV J17140261-2849237 = TCP J17140253-2849233 was discovered by H. Nishimura, T. Kojima, K. Nishiyama and F. Kabashima. A. Takao reports the transient (9.5mag) visible at unfiltered images obtained on 2018-03-10.753 UT. Spectroscopic observations with the 2m Liverpool Telescope confirmed the transient to be a Fe II type nova (ATel #11398).

Differences in cocaine-induced place preference persistence, locomotion and social behaviors between C57BL/6J and BALB/cJ mice

PubMed Central

WANG, Jian-Li; WANG, Bei; CHEN, Wen

2014-01-01

C57BL/6J and BALB/cJ mice display significant differences in sociability and response to drugs, but the phenotypic variability of their susceptibility to cocaine is still not well known. In this study, the differences between these two mice strains in the persistence of cocaine-induced conditioned place preference (CPP), as well as the locomotion and social behaviors after the 24-hour withdrawal from a four-day cocaine (20 mg/kg/day) administration were investigated. The results showed that the cocaine-induced CPP persisted over two weeks in C57BL/6J mice, while it diminished within one week among BALB/cJ mice. After 24-hours of cocaine withdrawal, high levels of locomotion as well as low levels of social interaction and aggressive behavior were found in C57BL/6J mice, but no significant changes were found in BALB/cJ mice, indicating that cocaine-induced CPP persistence, locomotion and social behavior are not consistent between these two strains, and that overall C57BL/6J mice are more susceptible to cocaine than BALB/cJ mice at the tested doses. PMID:25297083

Differences in cocaine-induced place preference persistence, locomotion and social behaviors between C57BL/6J and BALB/cJ mice.

PubMed

Wang, Jian-Li; Wang, Bei; Chen, Wen

2014-09-01

C57BL/6J and BALB/cJ mice display significant differences in sociability and response to drugs, but the phenotypic variability of their susceptibility to cocaine is still not well known. In this study, the differences between these two mice strains in the persistence of cocaine-induced conditioned place preference (CPP), as well as the locomotion and social behaviors after the 24-hour withdrawal from a four-day cocaine (20 mg/kg/day) administration were investigated. The results showed that the cocaine-induced CPP persisted over two weeks in C57BL/6J mice, while it diminished within one week among BALB/cJ mice. After 24-hours of cocaine withdrawal, high levels of locomotion as well as low levels of social interaction and aggressive behavior were found in C57BL/6J mice, but no significant changes were found in BALB/cJ mice, indicating that cocaine-induced CPP persistence, locomotion and social behavior are not consistent between these two strains, and that overall C57BL/6J mice are more susceptible to cocaine than BALB/cJ mice at the tested doses.

22 CFR 505.13 - General exemptions (Subsection (j)).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true General exemptions (Subsection (j)). 505.13... exemptions (Subsection (j)). (a) General exemptions are available for systems of records which are maintained by the Central Intelligence Agency (Subsection (j)(1)), or maintained by an agency which performs as...

Driving missing data at the LHC: NNLO predictions for the ratio of γ + j and Z + j

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, John M.; Ellis, R. Keith; Williams, Ciaran

In this paper we present a calculation of themore » $$\\gamma+j$$ process at next-to-next-to-leading order (NNLO) in QCD and compare the resulting predictions to 8 TeV CMS data. We find good agreement with the shape of the photon $$p_T$$ spectrum, particularly after the inclusion of additional electroweak corrections, but there is a tension between the overall normalization of the theoretical prediction and the measurement. We use our results to compute the ratio of $$Z(\\to \\ell^+\\ell^-)+j$$ to $$\\gamma+j$$ events as a function of the vector boson transverse momentum at NNLO, a quantity that is used to normalize $$Z(\\rightarrow\

Spinon excitation spectra of the J1-J2 chain from analytical calculations in the dimer basis and exact diagonalization

NASA Astrophysics Data System (ADS)

Lavarélo, Arthur; Roux, Guillaume

2014-10-01

The excitation spectrum of the frustrated spin-1/2 Heisenberg chain is reexamined using variational and exact diagonalization calculations. We show that the overlap matrix of the short-range resonating valence bond states basis can be inverted which yields tractable equations for single and two spinons excitations. Older results are recovered and new ones, such as the bond-state dispersion relation and its size with momentum at the Majumdar-Ghosh point are found. In particular, this approach yields a gap opening at J 2 = 0.25 J 1 and an onset of incommensurability in the dispersion relation at J 2 = 9/17 J 1 as in [S. Brehmer et al., J. Phys.: Condens. Matter 10, 1103 (1998)]. These analytical results provide a good support for the understanding of exact diagonalization spectra, assuming an independent spinons picture.

Analysis of a Current-Mode Detector for the NOPTREX Experiment

NASA Astrophysics Data System (ADS)

Olivera Velarde, Daniela; Noptrex Collaboration

2017-09-01

Charge, Parity and Time reversal (CPT) symmetries are an important aspect of the Standard Model. One of the outstanding problems in cosmology is the observed matter/antimatter asymmetry seen in the universe, which requires the violation of time reversal symmetry (T). The primary goal of the Neutron Optics Time Reversal Experiment (NOPTREX) is to search for T-violation in polarized neutron transmission through a polarized nuclear target. Preliminary measurements were taken on indium and tantalum resonances at the NOBORU test beam at the Japan Proton Accelerator Research Complex (J-PARC) to test the functionality of a prototype detector for the full experiment. We will discuss the analysis of this data as well as the construction of a secondary experiment to measure the angular correlation κ (J) of liquid 131Xe. This work was supported by the Department of Energy under Contract DE-SC0008107 and Berea College Office of Internships.

Staff - Gabriel J. Wolken | Alaska Division of Geological & Geophysical

Science.gov Websites

Facebook DGGS News Natural Resources Geological & Geophysical Surveys Staff - Gabriel J. Wolken main content Gabriel J. Wolken Gabriel J. Wolken Glaciology, climatology, geomorphology, snow science, geologic ., 2014, Arctic glaciers and ice caps (outside Greenland), in Blunden, J. and Arndt, D.S., eds., State of

Measurement of Γee(J /ψ) with KEDR detector

NASA Astrophysics Data System (ADS)

Anashin, V. V.; Aulchenko, V. M.; Baldin, E. M.; Barladyan, A. K.; Barnyakov, A. Y.; Barnyakov, M. Y.; Baru, S. E.; Bedny, I. V.; Blinov, A. E.; Blinov, V. E.; Bobrov, A. V.; Bobrovnikov, V. S.; Bogomyagkov, A. V.; Bondar, A. E.; Bondarev, D. V.; Buzykaev, A. R.; Eidelman, S. I.; Glukhovchenko, Y. M.; Gulevich, V. V.; Gusev, D. V.; Karnaev, S. E.; Karpov, G. V.; Karpov, S. V.; Kharlamova, T. A.; Kiselev, V. A.; Kononov, S. A.; Kotov, K. Y.; Kravchenko, E. A.; Kulikov, V. F.; Kurkin, G. Y.; Kuper, E. A.; Levichev, E. B.; Maksimov, D. A.; Malyshev, V. M.; Maslennikov, A. L.; Medvedko, A. S.; Meshkov, O. I.; Mishnev, S. I.; Morozov, I. I.; Muchnoi, N. Y.; Neufeld, V. V.; Nikitin, S. A.; Nikolaev, I. B.; Okunev, I. N.; Onuchin, A. P.; Oreshkin, S. B.; Orlov, I. O.; Osipov, A. A.; Peleganchuk, S. V.; Pivovarov, S. G.; Piminov, P. A.; Petrov, V. V.; Poluektov, A. O.; Popkov, I. N.; Prisekin, V. G.; Rezanova, O. L.; Ruban, A. A.; Sandyrev, V. K.; Savinov, G. A.; Shamov, A. G.; Shatilov, D. N.; Shwartz, B. A.; Simonov, E. A.; Sinyatkin, S. V.; Skovpen, Y. I.; Skrinsky, A. N.; Smaluk, V. V.; Sokolov, A. V.; Sukharev, A. M.; Starostina, E. V.; Talyshev, A. A.; Tayursky, V. A.; Telnov, V. I.; Tikhonov, Y. A.; Todyshev, K. Y.; Tumaikin, G. M.; Usov, Y. V.; Vorobiov, A. I.; Yushkov, A. N.; Zhilich, V. N.; Zhulanov, V. V.; Zhuravlev, A. N.

2018-05-01

The product of the electronic width of the J/ψ meson and the branching fractions of its decay to hadrons and electrons has been measured using the KEDR detector at the VEPP-4M e + e - collider. The obtained values are Γ_{ee}(J/ψ )=5.550± 0.056± 0.089 Γ_{ee}(J/ψ )\\cdotp B_{hadrons}(J/ψ )=4.884± 0.048± 0.078 keV Γ_{ee}(J/ψ )\\cdotp B_{ee}(J/ψ )=0.3331± 0.0066± 0.0040 keV. The uncertainties shown are statistical and systematic, respectively. Using the result presented and the world-average value of the electronic branching fraction, one obtains the total width of the J/ψ meson: Γ =92.94± 1.83keV. These results are consistent with the previous experiments.

Association of Escherichia coli J5-specific serum antibody responses with clinical mastitis outcome for J5 vaccinate and control dairy cattle.

PubMed

Wilson, David J; Mallard, Bonnie A; Burton, Jeanne L; Schukken, Ynte H; Grohn, Yrjo T

2009-02-01

Dairy cattle in two commercial Holstein herds were randomly selected to be vaccinated twice with J5, at approximately 60 days and 28 days before the expected calving date, or to be untreated controls. Based on whether milk production changed following clinical mastitis or whether cows were culled or died within 30 days after onset, 51 mastitis cases were classified as severe or mild. J5-specific antibody responses were evaluated by enzyme-linked immunosorbent assay of all 32 severe and 19 mild cases. The amounts of J5-specific immunoglobulin M (IgM), IgG1, and IgG2 antibodies in sera from the 27 J5 vaccinates were compared with those of the 24 controls. At drying off (before J5 vaccination), all cows had similar amounts of J5-specific antibody. Immediately after calving (approximately 28 days after the second vaccination), J5 vaccinates had significantly higher production of J5-specific IgG1 and IgG2 than controls. When cows were tested following clinical mastitis, none of the three antibody classes differed significantly between the controls and the vaccinates. Vaccinates that contracted Escherichia coli mastitis had 75% less milk loss than controls. The cows that contracted clinical mastitis later in lactation, the unvaccinated controls, and those infected with E. coli had more milk loss following mastitis. The hazards of being culled for all reasons and of being culled for mastitis were significantly lower for J5 vaccinates. Vaccination with J5 was associated with protection against milk production loss and culling following clinical mastitis, and it was also significantly associated with changes in J5-specific IgM, IgG1, and IgG2 antibodies in sera of vaccinated cows.

Bound on the Ratio of Decay Amplitudes for B¯0→J/ψK*0 and B0→J/ψK*0

NASA Astrophysics Data System (ADS)

Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Gaillard, J.-M.; Hicheur, A.; Karyotakis, Y.; Lees, J. P.; Tisserand, V.; Zghiche, A.; Palano, A.; Pompili, A.; Chen, J. C.; Qi, N. D.; Rong, G.; Wang, P.; Zhu, Y. S.; Eigen, G.; Ofte, I.; Stugu, B.; Abrams, G. S.; Borgland, A. W.; Breon, A. B.; Brown, D. N.; Button-Shafer, J.; Cahn, R. N.; Charles, E.; Day, C. T.; Gill, M. S.; Gritsan, A. V.; Groysman, Y.; Jacobsen, R. G.; Kadel, R. W.; Kadyk, J.; Kerth, L. T.; Kolomensky, Yu. G.; Kukartsev, G.; Lynch, G.; Mir, L. M.; Oddone, P. J.; Orimoto, T. J.; Pripstein, M.; Roe, N. A.; Ronan, M. T.; Shelkov, V. G.; Wenzel, W. A.; Ford, K. E.; Harrison, T. J.; Hawkes, C. M.; Morgan, S. E.; Watson, A. T.; Fritsch, M.; Goetzen, K.; Held, T.; Koch, H.; Lewandowski, B.; Pelizaeus, M.; Steinke, M.; Boyd, J. T.; Chevalier, N.; Cottingham, W. N.; Kelly, M. P.; Latham, T. E.; Wilson, F. F.; Cuhadar-Donszelmann, T.; Hearty, C.; Knecht, N. S.; Mattison, T. S.; McKenna, J. A.; Thiessen, D.; Khan, A.; Kyberd, P.; Teodorescu, L.; Blinov, V. E.; Bukin, A. D.; Druzhinin, V. P.; Golubev, V. B.; Ivanchenko, V. N.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Yushkov, A. N.; Best, D.; Bruinsma, M.; Chao, M.; Eschrich, I.; Kirkby, D.; Lankford, A. J.; Mandelkern, M.; Mommsen, R. K.; Roethel, W.; Stoker, D. P.; Buchanan, C.; Hartfiel, B. L.; Gary, J. W.; Shen, B. C.; Wang, K.; del Re, D.; Hadavand, H. K.; Hill, E. J.; Macfarlane, D. B.; Paar, H. P.; Rahatlou, Sh.; Sharma, V.; Berryhill, J. W.; Campagnari, C.; Dahmes, B.; Levy, S. L.; Long, O.; Lu, A.; Mazur, M. A.; Richman, J. D.; Verkerke, W.; Beck, T. W.; Eisner, A. M.; Heusch, C. A.; Lockman, W. S.; Schalk, T.; Schmitz, R. E.; Schumm, B. A.; Seiden, A.; Spradlin, P.; Williams, D. C.; Wilson, M. G.; Albert, J.; Chen, E.; Dubois-Felsmann, G. P.; Dvoretskii, A.; Hitlin, D. G.; Narsky, I.; Piatenko, T.; Porter, F. C.; Ryd, A.; Samuel, A.; Yang, S.; Jayatilleke, S.; Mancinelli, G.; Meadows, B. T.; Sokoloff, M. D.; Abe, T.; Blanc, F.; Bloom, P.; Chen, S.; Ford, W. T.; Nauenberg, U.; Olivas, A.; Rankin, P.; Smith, J. G.; Zhang, J.; Zhang, L.; Chen, A.; Harton, J. L.; Soffer, A.; Toki, W. H.; Wilson, R. J.; Zeng, Q. L.; Altenburg, D.; Brandt, T.; Brose, J.; Colberg, T.; Dickopp, M.; Feltresi, E.; Hauke, A.; Lacker, H. M.; Maly, E.; Müller-Pfefferkorn, R.; Nogowski, R.; Otto, S.; Petzold, A.; Schubert, J.; Schubert, K. R.; Schwierz, R.; Spaan, B.; Sundermann, J. E.; Bernard, D.; Bonneaud, G. R.; Brochard, F.; Grenier, P.; Schrenk, S.; Thiebaux, Ch.; Vasileiadis, G.; Verderi, M.; Bard, D. J.; Clark, P. J.; Lavin, D.; Muheim, F.; Playfer, S.; Xie, Y.; Andreotti, M.; Azzolini, V.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Luppi, E.; Negrini, M.; Piemontese, L.; Sarti, A.; Treadwell, E.; Baldini-Ferroli, R.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Patteri, P.; Piccolo, M.; Zallo, A.; Buzzo, A.; Capra, R.; Contri, R.; Crosetti, G.; Lo Vetere, M.; Macri, M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Tosi, S.; Bailey, S.; Brandenburg, G.; Morii, M.; Won, E.; Dubitzky, R. S.; Langenegger, U.; Bhimji, W.; Bowerman, D. A.; Dauncey, P. D.; Egede, U.; Gaillard, J. R.; Morton, G. W.; Nash, J. A.; Taylor, G. P.; Charles, M. J.; Grenier, G. J.; Mallik, U.; Cochran, J.; Crawley, H. B.; Lamsa, J.; Meyer, W. T.; Prell, S.; Rosenberg, E. I.; Yi, J.; Davier, M.; Grosdidier, G.; Höcker, A.; Laplace, S.; Le Diberder, F.; Lepeltier, V.; Lutz, A. M.; Petersen, T. C.; Plaszczynski, S.; Schune, M. H.; Tantot, L.; Wormser, G.; Cheng, C. H.; Lange, D. J.; Simani, M. C.; Wright, D. M.; Bevan, A. J.; Coleman, J. P.; Fry, J. R.; Gabathuler, E.; Gamet, R.; Parry, R. J.; Payne, D. J.; Sloane, R. J.; Touramanis, C.; Back, J. J.; Cormack, C. M.; Harrison, P. F.; Mohanty, G. B.; Brown, C. L.; Cowan, G.; Flack, R. L.; Flaecher, H. U.; Green, M. G.; Marker, C. E.; McMahon, T. R.; Ricciardi, S.; Salvatore, F.; Vaitsas, G.; Winter, M. A.; Brown, D.; Davis, C. L.; Allison, J.; Barlow, N. R.; Barlow, R. J.; Hart, P. A.; Hodgkinson, M. C.; Lafferty, G. D.; Lyon, A. J.; Williams, J. C.; Farbin, A.; Hulsbergen, W. D.; Jawahery, A.; Kovalskyi, D.; Lae, C. K.; Lillard, V.; Roberts, D. A.; Blaylock, G.; Dallapiccola, C.; Flood, K. T.; Hertzbach, S. S.; Kofler, R.; Koptchev, V. B.; Moore, T. B.; Saremi, S.; Staengle, H.; Willocq, S.; Cowan, R.; Sciolla, G.; Taylor, F.; Yamamoto, R. K.; Mangeol, D. J.; Patel, P. M.; Robertson, S. H.; Lazzaro, A.; Palombo, F.; Bauer, J. M.; Cremaldi, L.; Eschenburg, V.; Godang, R.; Kroeger, R.; Reidy, J.; Sanders, D. A.; Summers, D. J.; Zhao, H. W.; Brunet, S.; Côté, D.; Taras, P.; Nicholson, H.; Cavallo, N.; Fabozzi, F.; Gatto, C.; Lista, L.; Monorchio, D.; Paolucci, P.; Piccolo, D.; Sciacca, C.; Baak, M.; Bulten, H.; Raven, G.; Wilden, L.; Jessop, C. P.; Losecco, J. M.; Gabriel, T. A.; Allmendinger, T.; Brau, B.; Gan, K. K.; Honscheid, K.; Hufnagel, D.; Kagan, H.; Kass, R.; Pulliam, T.; Rahimi, A. M.; Ter-Antonyan, R.; Wong, Q. K.; Brau, J.; Frey, R.; Igonkina, O.; Potter, C. T.; Sinev, N. B.; Strom, D.; Torrence, E.; Colecchia, F.; Dorigo, A.; Galeazzi, F.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Tiozzo, G.; Voci, C.; Benayoun, M.; Briand, H.; Chauveau, J.; David, P.; de La Vaissière, Ch.; del Buono, L.; Hamon, O.; John, M. J.; Leruste, Ph.; Malcles, J.; Ocariz, J.; Pivk, M.; Roos, L.; T'jampens, S.; Therin, G.; Manfredi, P. F.; Re, V.; Behera, P. K.; Gladney, L.; Guo, Q. H.; Panetta, J.; Anulli, F.; Biasini, M.; Peruzzi, I. M.; Pioppi, M.; Angelini, C.; Batignani, G.; Bettarini, S.; Bondioli, M.; Bucci, F.; Calderini, G.; Carpinelli, M.; del Gamba, V.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Martinez-Vidal, F.; Morganti, M.; Neri, N.; Paoloni, E.; Rama, M.; Rizzo, G.; Sandrelli, F.; Walsh, J.; Haire, M.; Judd, D.; Paick, K.; Wagoner, D. E.; Danielson, N.; Elmer, P.; Lau, Y. P.; Lu, C.; Miftakov, V.; Olsen, J.; Smith, A. J.; Telnov, A. V.; Bellini, F.; Cavoto, G.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Li Gioi, L.; Mazzoni, M. A.; Morganti, S.; Pierini, M.; Piredda, G.; Tehrani, F. Safai; Voena, C.; Christ, S.; Wagner, G.; Waldi, R.; Adye, T.; de Groot, N.; Franek, B.; Geddes, N. I.; Gopal, G. P.; Olaiya, E. O.; Aleksan, R.; Emery, S.; Gaidot, A.; Ganzhur, S. F.; Giraud, P.-F.; Hamel de Monchenault, G.; Kozanecki, W.; Langer, M.; Legendre, M.; London, G. W.; Mayer, B.; Schott, G.; Vasseur, G.; Yèche, Ch.; Zito, M.; Purohit, M. V.; Weidemann, A. W.; Wilson, J. R.; Yumiceva, F. X.; Aston, D.; Bartoldus, R.; Berger, N.; Boyarski, A. M.; Buchmueller, O. L.; Convery, M. R.; Cristinziani, M.; de Nardo, G.; Dong, D.; Dorfan, J.; Dujmic, D.; Dunwoodie, W.; Elsen, E. E.; Fan, S.; Field, R. C.; Glanzman, T.; Gowdy, S. J.; Hadig, T.; Halyo, V.; Hast, C.; Hryn'ova, T.; Innes, W. R.; Kelsey, M. H.; Kim, P.; Kocian, M. L.; Leith, D. W.; Libby, J.; Luitz, S.; Luth, V.; Lynch, H. L.; Marsiske, H.; Messner, R.; Muller, D. R.; O'Grady, C. P.; Ozcan, V. E.; Perazzo, A.; Perl, M.; Petrak, S.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Schwiening, J.; Simi, G.; Snyder, A.; Soha, A.; Stelzer, J.; Su, D.; Sullivan, M. K.; Va'Vra, J.; Wagner, S. R.; Weaver, M.; Weinstein, A. J.; Wisniewski, W. J.; Wittgen, M.; Wright, D. H.; Yarritu, A. K.; Young, C. C.; Burchat, P. R.; Edwards, A. J.; Meyer, T. I.; Petersen, B. A.; Roat, C.; Ahmed, S.; Alam, M. S.; Ernst, J. A.; Saeed, M. A.; Saleem, M.; Wappler, F. R.; Bugg, W.; Krishnamurthy, M.; Spanier, S. M.; Eckmann, R.; Kim, H.; Ritchie, J. L.; Satpathy, A.; Schwitters, R. F.; Izen, J. M.; Kitayama, I.; Lou, X. C.; Ye, S.; Bianchi, F.; Bona, M.; Gallo, F.; Gamba, D.; Borean, C.; Bosisio, L.; Cartaro, C.; Cossutti, F.; della Ricca, G.; Dittongo, S.; Grancagnolo, S.; Lanceri, L.; Poropat, P.; Vitale, L.; Vuagnin, G.; Panvini, R. S.; Banerjee, Sw.; Brown, C. M.; Fortin, D.; Jackson, P. D.; Kowalewski, R.; Roney, J. M.; Band, H. R.; Dasu, S.; Datta, M.; Eichenbaum, A. M.; Graham, M.; Hollar, J. J.; Johnson, J. R.; Kutter, P. E.; Li, H.; Liu, R.; Lodovico, F. Di; Mihalyi, A.; Mohapatra, A. K.; Pan, Y.; Prepost, R.; Rubin, A. E.; Sekula, S. J.; Tan, P.; von Wimmersperg-Toeller, J. H.; Wu, J.; Wu, S. L.; Yu, Z.; Greene, M. G.; Neal, H.

2004-08-01

We have measured the time-dependent decay rate for the process B→J/ψK*0(892) in a sample of about 88×106 Υ(4S)→BB¯ decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. In this sample we study flavor-tagged events in which one neutral B meson is reconstructed in the J/ψK*0 or J/ψK¯*0 final state. We measure the coefficients of the cosine and sine terms in the time-dependent asymmetries for J/ψK*0 and J/ψK¯*0, find them to be consistent with the standard model expectations, and set upper limits at 90% confidence level (C.L.) on the decay amplitude ratios |A(B¯0→J/ψK*0)|/|A(B0→J/ψK*0)|<0.26 and |A(B0→J/ψK¯*0)|/|A(B¯0→J/ψK¯*0)|<0.32. For a single ratio of wrong-flavor to favored amplitudes for B0 and B¯0 combined, we obtain an upper limit of 0.25 at 90% C.L.

J-2X Abort System Development

NASA Technical Reports Server (NTRS)

Santi, Louis M.; Butas, John P.; Aguilar, Robert B.; Sowers, Thomas S.

2008-01-01

The J-2X is an expendable liquid hydrogen (LH2)/liquid oxygen (LOX) gas generator cycle rocket engine that is currently being designed as the primary upper stage propulsion element for the new NASA Ares vehicle family. The J-2X engine will contain abort logic that functions as an integral component of the Ares vehicle abort system. This system is responsible for detecting and responding to conditions indicative of impending Loss of Mission (LOM), Loss of Vehicle (LOV), and/or catastrophic Loss of Crew (LOC) failure events. As an earth orbit ascent phase engine, the J-2X is a high power density propulsion element with non-negligible risk of fast propagation rate failures that can quickly lead to LOM, LOV, and/or LOC events. Aggressive reliability requirements for manned Ares missions and the risk of fast propagating J-2X failures dictate the need for on-engine abort condition monitoring and autonomous response capability as well as traditional abort agents such as the vehicle computer, flight crew, and ground control not located on the engine. This paper describes the baseline J-2X abort subsystem concept of operations, as well as the development process for this subsystem. A strategy that leverages heritage system experience and responds to an evolving engine design as well as J-2X specific test data to support abort system development is described. The utilization of performance and failure simulation models to support abort system sensor selection, failure detectability and discrimination studies, decision threshold definition, and abort system performance verification and validation is outlined. The basis for abort false positive and false negative performance constraints is described. Development challenges associated with information shortfalls in the design cycle, abort condition coverage and response assessment, engine-vehicle interface definition, and abort system performance verification and validation are also discussed.

Unveiling the radio counterparts of two binary AGN candidates: J1108+0659 and J1131-0204

NASA Astrophysics Data System (ADS)

Bondi, M.; Pérez-Torres, M. A.; Piconcelli, E.; Fu, H.

2016-04-01

The sources SDSS J113126.08-020459.2 and SDSS J110851.04+065901.4 are two double-peaked [O III] emitting active galactic nuclei (AGNs), identified as candidate binary AGNs by optical and near infrared (NIR) observations. We observed the two sources with high resolution Very Long Baseline Interferometry (VLBI) using the European VLBI Network at 5 GHz, reduced VLA observations at three frequencies available for one of the sources, and used archival HST observations. For the source SDSS J113126.08-020459.2, the VLBI observations detected only one single compact component associated with the eastern NIR nucleus. In SDSS J110851.04+065901.4, the VLBI observations did not detect any compact components, but the VLA observations allowed us to identify a possible compact core in the region of the north-western optical/NIR nucleus. In this source we find kpc-scale extended radio emission that is spatially coincident to the ultraviolet continuum and to the extended emission narrow line region. The UV continuum is significantly obscured since the amount of extended radio emission yields a star formation rate of about 110 M⊙ yr-1, which is an order of magnitude larger than implied by the observed ultraviolet emission. Our analysis confirms the presence of only one AGN in the two candidate binary AGNs. FITS files of the reduced images are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/588/A102

Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice

NASA Astrophysics Data System (ADS)

Wu, Ruirui; Wu, Xiafang; Wang, Huihui; Fang, Xin; Li, Yongfang; Gao, Lanyue; Sun, Guifan; Pi, Jingbo; Xu, Yuanyuan

2017-03-01

Arsenic is a common environmental and occupational toxicant with dramatic species differences in its susceptibility and metabolism. Mouse strain variability may provide a better understanding of the arsenic pathological profile but is largely unknown. Here we investigated oxidative lesion induced by acute arsenic exposure in the two frequently used mouse strains C57BL/6J and 129X1/SvJ in classical gene targeting technique. A dose of 5 mg/kg body weight arsenic led to a significant alteration of blood glutathione towards oxidized redox potential and increased hepatic malondialdehyde content in C57BL/6J mice, but not in 129X1/SvJ mice. Hepatic antioxidant enzymes were induced by arsenic in transcription in both strains and many were higher in C57BL/6J than 129X1/SvJ mice. Arsenic profiles in the liver, blood and urine and transcription of genes encoding enzymes involved in arsenic biomethylation all indicate a higher arsenic methylation capacity, which contributes to a faster hepatic arsenic excretion, in 129X1/SvJ mice than C57BL/6J mice. Taken together, C57BL/6J mice are more susceptible to oxidative hepatic injury compared with 129X1/SvJ mice after acute arsenic exposure, which is closely associated with arsenic methylation pattern of the two strains.

VizieR Online Data Catalog: PSR J1023+0038 & XSS J12270-4859 VRi polarimetry (Baglio+, 2016)

NASA Astrophysics Data System (ADS)

Baglio, M. C.; D'Avanzo, P.; Campana, S.; Coti Zelati, F.; Covino, S.; Russell, D. M.

2016-05-01

The systems PSR J1023+0038 and XSS J12270-4859 were observed in quiescence on 8 and 9 February 2015 (respectively) with the ESO New Technology Telescope (NTT) located at La Silla (Chile), equipped with the EFOSC2 camera in polarimetric mode, using the B, V, R, i filters. (6 data files).

Dalitz plot analyses of J / ψ → π + π - π 0 , J / ψ → K + K - π 0 , and J / ψ → K s 0 K ± π ∓ produced via e + e - annihilation with initial-state radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lees, J. P.; Poireau, V.; Tisserand, V.

Here, we study the processes e +e - → γ ISR J/ψ , where J/ψ → π +π -π 0, J/ψ → K +K -π 0 , and J / ψ → Kmore » $$0\\atop{S}$$ K ± π ∓ using a data sample of 519 fb -1 recorded with the BABAR detector operating at the SLAC PEP-II asymmetric-energy e +e - collider at center-of-mass energies at and near the Υ (nS) (n = 2 , 3 , 4) resonances. We measure the ratio of branching fractions R 1 = $$B(J/ψ →K^+K^- π^0)\\atop{B(J/ψ →π^+π^- π^0)}$$ and R 2= $$B(J/ψ →K^0_SK^±π^∓)\\atop{B(J/ψ →π^+π^- π^0)}$$. We perform Dalitz plot analyses of the three J/ψ decay modes and measure fractions for resonances contributing to the decays. We also analyze the J/ψ → $π^+π^- π^0$ decay using the Veneziano model. We observe structures compatible with the presence of ρ (1450) in all three J/ψ decay modes and measure the relative branching fraction: R (p(1450)) = $$Bp(1450)→K^+K^-)\\atop{B(p(1450)→π^+π^-)}$$ +0.307 ± 0.084 (stat) ± 0.082 (sys).« less

Dalitz plot analyses of J / ψ → π + π - π 0 , J / ψ → K + K - π 0 , and J / ψ → K s 0 K ± π ∓ produced via e + e - annihilation with initial-state radiation

DOE PAGES

Lees, J. P.; Poireau, V.; Tisserand, V.; ...

2017-04-10

Here, we study the processes e +e - → γ ISR J/ψ , where J/ψ → π +π -π 0, J/ψ → K +K -π 0 , and J / ψ → Kmore » $$0\\atop{S}$$ K ± π ∓ using a data sample of 519 fb -1 recorded with the BABAR detector operating at the SLAC PEP-II asymmetric-energy e +e - collider at center-of-mass energies at and near the Υ (nS) (n = 2 , 3 , 4) resonances. We measure the ratio of branching fractions R 1 = $$B(J/ψ →K^+K^- π^0)\\atop{B(J/ψ →π^+π^- π^0)}$$ and R 2= $$B(J/ψ →K^0_SK^±π^∓)\\atop{B(J/ψ →π^+π^- π^0)}$$. We perform Dalitz plot analyses of the three J/ψ decay modes and measure fractions for resonances contributing to the decays. We also analyze the J/ψ → $π^+π^- π^0$ decay using the Veneziano model. We observe structures compatible with the presence of ρ (1450) in all three J/ψ decay modes and measure the relative branching fraction: R (p(1450)) = $$Bp(1450)→K^+K^-)\\atop{B(p(1450)→π^+π^-)}$$ +0.307 ± 0.084 (stat) ± 0.082 (sys).« less

Joint Spacelab-J (SL-J) Activities at the Huntsville Operations Support Center (HOSC) Spacelab

NASA Technical Reports Server (NTRS)

1999-01-01

The science laboratory, Spacelab-J (SL-J), flown aboard the STS-47 flight was a joint venture between NASA and the National Space Development Agency of Japan (NASDA) utilizing a manned Spacelab module. The mission conducted 24 materials science and 20 life science experiments, of which 35 were sponsored by NASDA, 7 by NASA, and two collaborative efforts. Materials science investigations covered such fields as biotechnology, electronic materials, fluid dynamics and transport phenomena, glasses and ceramics, metals and alloys, and acceleration measurements. Life sciences included experiments on human health, cell separation and biology, developmental biology, animal and human physiology and behavior, space radiation, and biological rhythms. Test subjects included the crew, Japanese koi fish (carp), cultured animal and plant cells, chicken embryos, fruit flies, fungi and plant seeds, and frogs and frog eggs. Featured together in joint ground activities during the SL-J mission are NASA/NASDA personnel at the Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at Marshall Space Flight Center (MSFC).

Déjà vu experiences in patients with schizophrenia.

PubMed

Adachi, Takuya; Adachi, Naoto; Takekawa, Yoshikazu; Akanuma, Nozomi; Ito, Masumi; Matsubara, Ryouji; Ikeda, Hiroshi; Kimura, Michihiro; Arai, Heii

2006-01-01

To investigate whether déjà vu experiences are psychopathologic phenomena, we studied the frequency and characteristics of déjà vu experiences in patients with schizophrenia. One hundred thirteen patients with schizophrenia and 386 nonclinical control subjects were evaluated with the Inventory of Déjà vu Experiences Assessment. The frequency and features of déjà vu experiences were compared between the 2 groups. The patients with schizophrenia had déjà vu experiences less frequently (53.1%) than did the nonclinical subjects (76.2%). The frequency of déjà vu experiences did not correlate significantly with age at evaluation or education level among the patients with schizophrenia. Most characteristics of déjà vu experiences of the patients were comparable with those of the control subjects. However, the experiences of the patients tended to be longer and more monotonous. The patients often felt alert, oppressed, and disturbed by the experiences. They appeared to have the experiences under unpleasant mental or physical states. Their déjà vu experiences are not primarily different in nature from those of the nonclinical subjects. The decreased frequency of the experiences in the patients may suggest déjà vu experiences as nonpathologic phenomena.

The congenic normal R/APfd and jaundiced R/APfd-j/j rat strains: a new animal model of hereditary non-haemolytic unconjugated hyperbilirubinaemia due to defective bilirubin conjugation.

PubMed

Leyten, R; Vroemen, J P; Blanckaert, N; Heirwegh, K P

1986-10-01

In this paper the production of the R/APfd-j/j strain which is congenic with the R/APfd strain is reported. The R/APfd-j/j completely lacks hepatic bilirubin UDP-glucuronyltransferase activity, as do our GUNNXR/Pfd-j/j rat strain and various other stocks of GUNN rats (j/j) described in the literature. Our recombinant inbred strain GUNNXR/Pfd-j/j was produced from non-inbred GUNN (j/j) rats. This GUNNXR/Pfd-j/j rat was used as a donor of the jaundice gene j, the R/APfd rat serving as the recipient. After eight backcross-intercross cycles (16 generations) the R/APfd-j/j strain was obtained which is congenic with the R/APfd strain. Congenicity was demonstrated by various techniques including transplantation of skin tissue, strain-specific tumour cells and hepatocytes, the mixed lymphocyte reaction, and comparison of biochemical markers. The potential of the novel inbred strain of jaundiced rat, R/APfd-j/j, and the corresponding control strain R/APfd for biochemical and clinical studies of bilirubin metabolism are briefly discussed.

26 CFR 1.415(j)-1 - Limitation year.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Limitation year. 1.415(j)-1 Section 1.415(j)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.415(j)-1 Limitation year. (a) In...

Split Active Asteroid P/2016 J1 (PANSTARRS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hui, Man-To; Jewitt, David; Du, Xinnan, E-mail: pachacoti@ucla.edu

We present a photometric and astrometric study of the split active asteroid P/2016 J1 (PANSTARRS). The two components (hereafter J1-A and J1-B) separated either ∼1500 days (2012 May to June) or 2300 days (2010 April) prior to the current epoch, with a separation speed V {sub sep} = 0.70 ± 0.02 m s{sup −1} for the former scenario and 0.83 ± 0.06 m s{sup −1} for the latter. Keck photometry reveals that the two fragments have similar, Sun-like colors that are comparable to the colors of primitive C- and G-type asteroids. With a nominal comet-like albedo, p{sub R} = 0.04, the effective, dust-contaminated cross sections are estimated tomore » be 2.4 km{sup 2} for J1-A and 0.5 km{sup 2} for J1-B. We estimate that the nucleus radii lie in the range 140 ≲  R {sub N} ≲ 900 m for J1-A and 40 ≲  R {sub N} ≲ 400 m for J1-B. A syndyne–synchrone simulation shows that both components have been active for 3–6 months, by ejecting dust grains at speeds ∼0.5 m s{sup −1} with rates ∼1 kg s{sup −1} for J1-A and 0.1 kg s{sup −1} for J1-B. In its present orbit, the rotational spin-up and devolatilization times of 2016 J1 are very small compared to the age of the solar system, raising the question of why this object still exists. We suggest that ice that was formerly buried within this asteroid became exposed at the surface, perhaps via a small impact, and that sublimation torques then rapidly drove it to breakup. Further disintegration events are anticipated owing to the rotational instability.« less

J-PLUS: The Javalambre Photometric Local Universe Survey

NASA Astrophysics Data System (ADS)

Cenarro, Javier; Marin-Franch, Antonio; Moles, Mariano; Cristobal-Hornillos, David; Mendes de Oliveira, Claudia; Sodre, Laerte

2015-08-01

The Javalambre-Photometric Local Universe Survey, J-PLUS (www.j-plus.es), is defined to observe 8500 deg2 of the sky visible from the Javalambre Observatory (Teruel, Spain) with the panoramic camera T80Cam at the JAST/T80 telescope, using a set of 12 broad, intermediate and narrow band optical filters. The Project is particularly designed to carry out the photometric calibration of J-PAS (http://j-pas.org). For this reason, some J-PLUS filters are located at key stellar spectral features that allow to retrieve very accurate spectral energy distributions for more than 5 millions of stars in our Galaxy. Beyond the calibration goals, the unusually large FOV of T80Cam, 2deg2, together with the unique width and location of some filters, turn the J-PLUS Project into a powerful 3D view of the nearby Universe, mapping more than 20 millions of galaxies with reliable distance determinations and a similar number of stars of the Milky Way halo. At a rate of 100 gigabytes of data per night, J-PLUS will provide unprecedented multi-color images of the Universe to address a wide variety of astrophysical questions related with cosmology, large scale structure, galaxy clusters, 2D stellar populations and star formation studies in galaxies, the discovery of high redshift galaxies at specific redshift slices, quasars, supernovae, Milky Way science and structure, and minor bodies in the Solar System. In addition, the repetition of the whole area over time in certain filters will allow to face variability studies in the time domain.Complementing J-PLUS, a replica of the JAST/T80 telescope, T80Cam and the J-PLUS filters have been installed at the CTIO, allowing to extend the project to the Southern Hemisphere. J-PLUS together with the southern extension, S-PLUS, constitute an All-sky Photometric Local Universe Survey whose details and scientific applications are the bulk of the present talk.

Michael J. Fox: Spurring Research on Parkinson's

MedlinePlus

... on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past Issues / Winter 2014 Table of ... founded the Michael J. Fox Foundation for Parkinson's Research in the year 2000. Photo courtesy of Shutterstock " ...

STS-47 Spacelab-J Onboard Photograph

NASA Technical Reports Server (NTRS)

1992-01-01

The Spacelab-J (SL-J) mission was a joint venture between NASA and the National Space Development Agency of Japan (NASDA) utilizing a marned Spacelab module. Materials science investigations covered such fields as biotechnology, electronic materials, fluid dynamics and transport phenomena, glasses and ceramics, metals and alloys, and acceleration measurements. Life sciences included experiments on human health, cell separation and biology, developmental biology, animal and human physiology and behavior, space radiation, and biological rhythms. Before long-term space ventures are attempted, numerous questions must be answered: how will gravity play in the early development of an organism, and how will new generations of a species be conceived and develop normally in microgravity. The Effects of Weightlessness on the Development of Amphibian Eggs Fertilized in Space experiment aboard SL-J examined aspects of these questions. To investigate the effect of microgravity on amphibian development, female frogs carried aboard SL-J were induced to ovulate and shed eggs. These eggs were then fertilized in the microgravity environment. Half were incubated in microgravity, while the other half were incubated in a centrifuge that spins to simulate normal gravity. This photograph shows astronaut Mark Lee working with one of the adult female frogs inside the incubator. The mission also examined the swimming behavior of tadpoles grown in the absence of gravity. The Spacelab-J was launched aboard the Space Shuttle Orbiter Endeavour on September 12, 1992.

Exclusive decay of P-wave bottomonium into double J/{psi}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Juan; Institute of Theoretical Physics, Shanxi University, Taiyuan, Shanxi 030006; Dong Hairong

2011-11-01

We calculate the relativistic corrections of J/{psi}, including electromagnetic corrections, to {chi}{sub b}J{yields}J/{psi}J/{psi} in the framework of nonrelativistic QCD factorization. The relativistic effects are found to increase the lower-order prediction for the decay width by about 10%, while the electromagnetism contribution is very small, about 0.2% for {chi}{sub b0} and {chi}{sub b2}. The total branching ratios are predicted to be of order 10{sup -5} for {chi}{sub b0,b2}{yields}J/{psi}J/{psi}, but 10{sup -11} for {chi}{sub b1}{yields}J/{psi}J/{psi}, since there is only electromagnetism contribution in this channel. We predict it is possible to observe these reactions in LHC.

Spectral Variability of Two Rapidly Rotating Brown Dwarfs: 2MASS J08354256-0819237 and 2MASS J18212815+1414010

NASA Astrophysics Data System (ADS)

Schlawin, E.; Burgasser, Adam J.; Karalidi, T.; Gizis, J. E.; Teske, J.

2017-11-01

L dwarfs exhibit low-level, rotationally modulated photometric variability generally associated with heterogeneous, cloud-covered atmospheres. The spectral character of these variations yields insight into the particle sizes and vertical structure of the clouds. Here, we present the results of a high-precision, ground-based, near-infrared, spectral monitoring study of two mid-type L dwarfs that have variability reported in the literature, 2MASS J08354256-0819237 and 2MASS J18212815+1414010, using the SpeX instrument on the Infrared Telescope Facility. By simultaneously observing a nearby reference star, we achieve < 0.15 % per-band sensitivity in relative brightness changes across the 0.9-2.4 μm bandwidth. We find that 2MASS J0835-0819 exhibits marginal (≲0.5% per band) variability with no clear spectral dependence, while 2MASS J1821+1414 varies by up to ±1.5% at 0.9 μm, with the variability amplitude declining toward longer wavelengths. The latter result extends the variability trend observed in prior HST/WFC3 spectral monitoring of 2MASS J1821+1414, and we show that the full 0.9-2.4 μm variability amplitude spectrum can be reproduced by Mie extinction from dust particles with a log-normal particle size distribution with a median radius of 0.24 μm. We do not detect statistically significant phase variations with wavelength. The different variability behavior of 2MASS J0835-0819 and 2MASS J1821+1414 suggests dependencies on viewing angle and/or overall cloud content, underlying factors that can be examined through a broader survey.

Joint Chiefs of Staff > Directorates > J5 | Strategic Plans and Policy

Science.gov Websites

Quadrilateral Logistics Forum J5 | Strategic Plans and Policy J6 | C4 & Cyber J7 | Joint Force Development J8 | Force Structure, Resources & Assessment Contact J5 Strategic Plans and Policy Home : Directorates : J5 | Strategic Plans and Policy Mission The Joint Staff J5 proposes strategies, plans, and

Swift Follow up observation of the transient source Fermi J1654-1055 (PMN J1632-1052)

NASA Astrophysics Data System (ADS)

Ajello, M.; Kocevski, D.; Buson, S.; Buehler, R.; Giomi, M.

2016-02-01

On February 25, 2016, Swift carried out a 2ks target of opportunity observation of the transient Fermi J1654-1055 (see ATel #8721). Only one source is clearly detected, within the LAT error circle, by the Swift X-ray telescope (XRT) at RA, Dec= 16h 32m 49.9s, -10d 52' 30.1" (J2000) with a 90 % uncertainty radius of 6.3 arcsec.

28 CFR 0.29j - Law enforcement authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Law enforcement authority. 0.29j Section 0.29j Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE 4-Office of the Inspector General § 0.29j Law enforcement authority. Subject to guidelines promulgated by the Attorney General, Special Agents of the Offic...

A SELF-CONSISTENT EXPLANATION OF TeV EMISSIONS FROM HESS J1640-465 AND HESS J1641-463

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, Yunyong; Yang, Chuyuan; Wang, Jiancheng

2015-10-10

The bright TeV source HESS J1640-465 is positionally coincident with the young supernova remnant (SNR) G338.3-0.0, and the nearby HESS J1641-463 with TeV gamma-ray emission seems to be closely associated with it. Based on the nonlinear diffusion shock acceleration model, we explore the emission from these two TeV sources, the particle diffusion is assumed to be different inside and outside the absorbing boundary of the particles accelerated in the SNR shock. The results indicate that (1) the GeV–TeV emission from the region of the HESS J1640-465 is produced as a result of the particle acceleration inside the SNR G338.3-0.0 andmore » (2) the runaway cosmic-ray particles outside the SNR are interacting with the nearby dense molecular cloud (MC) at the region of the HESS J1641-463, corresponding π{sup 0} decay gamma-ray in proton–proton collision contribute to the TeV emission from the HESS J1641-463. Also, we investigate the possible X-ray emission in MC from the synchrotron procedure by secondary e{sup ±} produced through escaped protons interaction with the MC.« less

Increasingly automated procedure acquisition in dynamic systems

NASA Technical Reports Server (NTRS)

Mathe, Nathalie; Kedar, Smadar

1992-01-01

Procedures are widely used by operators for controlling complex dynamic systems. Currently, most development of such procedures is done manually, consuming a large amount of paper, time, and manpower in the process. While automated knowledge acquisition is an active field of research, not much attention has been paid to the problem of computer-assisted acquisition and refinement of complex procedures for dynamic systems. The Procedure Acquisition for Reactive Control Assistant (PARC), which is designed to assist users in more systematically and automatically encoding and refining complex procedures. PARC is able to elicit knowledge interactively from the user during operation of the dynamic system. We categorize procedure refinement into two stages: diagnosis - diagnose the failure and choose a repair - and repair - plan and perform the repair. The basic approach taken in PARC is to assist the user in all steps of this process by providing increased levels of assistance with layered tools. We illustrate the operation of PARC in refining procedures for the control of a robot arm.

Staff - Kurt J. Johnson | Alaska Division of Geological & Geophysical

Science.gov Websites

Facebook DGGS News Natural Resources Geological & Geophysical Surveys Staff - Kurt J. Johnson main content Kurt J. Johnson Kurt J. Johnson Position: Geologist, Geologic Materials Center Address: 3651

Photoproduction of {J}/{ψ} mesons at HERA

NASA Astrophysics Data System (ADS)

Ahmed, T.; Aid, S.; Andreev, V.; Andrieu, B.; Appuhn, R.-D.; Arpagaus, M.; Babaev, A.; Baehr, J.; Bán, J.; Baranov, P.; Barrelet, E.; Bartel, W.; Barth, M.; Bassler, U.; Beck, H. P.; Behrend, H.-J.; Belousov, A.; Berger, Ch.; Bergstein, H.; Bernardi, G.; Bernet, R.; Bertrand-Coremans, G.; Besançon, M.; Beyer, R.; Biddulph, P.; Bizot, J. C.; Blodel, V.; Borras, K.; Botterweck, F.; Borrdry, V.; Braemer, A.; Brasse, F.; Braunschweig, W.; Brisson, V.; Bruncko, D.; Brune, C.; Buchholz, R.; Büngener, L.; Bürger, J.; Büsser, F. W.; Buniatian, A.; Burke, S.; Buschhorn, G.; Campbell, A. J.; Carli, T.; Charles, F.; Clarke, D.; Clegg, A. B.; Colombo, M.; Contreras, J. G.; Coughlan, J. A.; Courau, A.; Coutures, Ch.; Cozzika, G.; Criegee, L.; Cussans, D. G.; Cvach, J.; Dagoret, S.; Dainton, J. B.; Danilov, M.; Dau, W. D.; Daum, K.; David, M.; Deffur, E.; Delcourt, B.; Del Buono, L.; De Roeck, A.; De Wolf, E. A.; Di Nezza, P.; Dollfus, C.; Dowell, J. D.; Dreis, H. B.; Duboc, J.; Düllmann, D.; Dünger, O.; Duhm, H.; Ebert, J.; Ebert, T. R.; Eckerlin, G.; Efremenko, V.; Egli, S.; Ehrlichmann, H.; Eichenberger, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellison, R. J.; Elsen, E.; Erdmann, M.; Erdmann, W.; Evrard, E.; Favart, L.; Fedotov, A.; Feeken, D.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrarotto, F.; Flamm, K.; Fleischer, M.; Flieser, M.; Flügge, G.; Fomenko, A.; Fominykh, B.; Forbush, M.; Formánek, J.; Foster, J. M.; Franke, G.; Fretwurst, E.; Gabathuler, E.; Gabathuler, K.; Gamerdinger, K.; Garvey, J.; Gayler, J.; Gebauer, M.; Gellrich, A.; Genzel, H.; Gerhards, R.; Goerlach, U.; Goerlich, L.; Gogitidze, N.; Goldberg, M.; Goldner, D.; Gonzalez-Pineiro, B.; Goodall, A. M.; Gorelov, I.; Goritchev, P.; Grab, C.; Grässler, H.; Grässler, R.; Greenshaw, T.; Grindhammer, G.; Gruber, A.; Grubber, C.; Haack, J.; Haidt, D.; Hajduk, L.; Hamon, O.; Hampel, M.; Hanlon, E. M.; Hapke, M.; Haynes, W. J.; Heatherington, J.; Hedberg, V.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Herma, R.; Herynek, I.; Hess, M. F.; Hildesheim, W.; Hill, P.; Hiller, K. H.; Hilton, C. D.; Hladký, J.; Hoeger, K. C.; Höppner, M.; Horisberger, R.; Huet, Ph.; Hufnagel, H.; Ibbotson, M.; Itterbeck, H.; Jabiol, M.-A.; Jacholkowska, A.; Jacobsson, C.; Jaffre, M.; Janoth, J.; Jansen, T.; Jönsson, L.; Johannsen, K.; Johnson, D. P.; Johnson, L.; Jung, H.; Kalmus, P. I. P.; Kant, D.; Kaschowitz, R.; Kasselmann, P.; Kathage, U.; Kaufmann, H. H.; Kazarian, S.; Kenyon, I. R.; Kermiche, S.; Keuker, C.; Kiesling, C.; Klein, M.; Kleinwort, C.; Knies, G.; Ko, W.; Köhler, T.; Kolanoski, H.; Kole, F.; Kolya, S. D.; Korbel, V.; Korn, M.; Kostka, P.; Kotelnikov, S. K.; Krasny, M. W.; Krehbiel, H.; Krücker, D.; Krüger, U.; Krüner-Marquis, U.; Kubenka, J. P.; Küster, H.; Kurlen, T.; Kurča, T.; Kurzhöfer, J.; Kuznik, B.; Lacour, D.; Lamarche, F.; Lander, R.; Landon, M. P. J.; Lange, W.; Lanius, P.; Laporte, J.-F.; Lebedev, A.; Leverenz, C.; Levonian, S.; Ley, Ch.; Lindner, A.; Lindström, G.; Linsel, F.; Lipinski, J.; List, B.; Loch, P.; Lohmander, H.; Lopez, G. C.; Lüke, D.; Magnussen, N.; Malinovski, E.; Mani, S.; Maraček, R.; Marage, P.; Marks, J.; Marshall, R.; Martens, J.; Martin, R.; Martyn, H.-U.; Martyniak, J.; Masson, S.; Mavroidis, T.; Maxfield, S. J.; McMahon, S. J.; Mehta, A.; Meier, K.; Mercer, D.; Merz, T.; Meyer, C. A.; Meyer, H.; Meyer, J.; Mikocki, S.; Milstead, D.; Moreau, F.; Morris, J. V.; Müller, G.; Müller, K.; Murín, P.; Nahnhauer, R.; Naroska, B.; Naumann, Th.; Newman, P. R.; Newton, D.; Neyret, D.; Nguyen, H. K.; Niebergall, F.; Niebuhr, C.; Nisius, R.; Nowak, G.; Noyes, G. W.; Nyberg-Werther, M.; Oberlack, H.; Obrock, U.; Olsson, J. E.; Panaro, E.; Panitch, A.; Pascaud, C.; Patel, G. D.; Peppel, E.; Perez, E.; Phillips, J. P.; Pichler, Ch.; Pitzl, D.; Pope, G.; Prell, S.; Prosi, R.; Rädel, G.; Raupach, F.; Reimer, P.; Reinshagen, S.; Ribarics, P.; Riech, V.; Riedlberger, J.; Riess, S.; Rietz, M.; Robertson, S. M.; Robmann, R.; Roloff, H. E.; Roosen, R.; Rosenbauer, K.; Rostovtsev, A.; Rouse, F.; Royon, C.; Rüter, K.; Rusakov, S.; Rybicki, K.; Rylko, R.; Sahlmann, N.; Sanchez, E.; Sankey, D. P. C.; Savitsky, M.; Schacht, P.; Schiek, S.; Schleper, P.; von Schlippe, W.; Schmidt, C.; Schmidt, D.; Schmidt, G.; Schöning, A.; Schröder, V.; Schuhmann, E.; Schwab, B.; Schwind, A.; Seehausen, U.; Sefkow, F.; Seidel, M.; Sell, R.; Semenov, A.; Shekelyan, V.; Sheviakov, I.; Shooshtari, H.; Shtarkov, L. N.; Siegmon, G.; Siewert, U.; Sirois, Y.; Skillicorn, I. O.; Smirnov, P.; Smith, J. R.; Soloviev, Y.; Spitzer, H.; Starosta, R.; Steenbock, M.; Steffen, P.; Steinberg, R.; Stella, B.; Stephens, K.; Stier, J.; Stiewe, J.; Stösslein, U.; Strachota, J.; Straumann, U.; Struczinski, W.; Sutton, J. P.; Tapprogge, S.; Taylor, R. E.; Tchernyshov, V.; Thiebaux, C.; Thompson, G.; Tichomirov, I.; Truöl, P.; Turnau, J.; Tutas, J.; Uelkes, P.; Usik, A.; Valkár, S.; Valkárová, A.; Vallée, C.; Van Esch, P.; Van Mechelen, P.; Vartapetian, A.; Vazdik, Y.; Vecko, M.; Verrecchia, P.; Villet, G.; Wacker, K.; Wagener, A.; Wagener, M.; Walker, I. W.; Walther, A.; Weber, G.; Weber, M.; Wegener, D.; Wegner, A.; Wellisch, H. P.; West, L. R.; Willard, S.; Winde, M.; Winter, G.-G.; Wright, A. E.; Wünsch, E.; Wulff, N.; Yiou, T. P.; Žáček, J.; Zarbock, D.; Zhang, Z.; Zimmer, M.; Zimmermann, W.; Zomer, F.; Zuber, K.; H1 Collaboration

1994-11-01

We present a study of {J}/{ψ} meson production in collisions of 26.7 GeV electrons with 820 GeV protons, performed with the H1-detector at the HERA collider at DESY. The {J}/{ψ} mesons are detected via their leptonic decays both to electrons and muons. Requiring exactly two particles in the detector, a cross section of σ(ep → {J}/{ψ}X) = (8.8±2.0±2.2) nb is determined for 30 GeV ≤ Wγp ≤ 180 GeV and Q2 ≲ 4 GeV 2. Using the flux of quasi-real photons with Q2 ≲ 4 GeV 2, a total production cross section of σ( γp → J/ ψX) = (56±13±14) nb is derived at an average Wγp=90 GeV. The distribution of the squared momentum transfer t from the proton to the {J}/{ψ} can be fitted using an exponential exp(- b∥ t∥) below a ∥ t∥ of 0.75 GeV 2 yielding a slope parameter of b = (4.7±1.9) GeV -2.

J Waves for Predicting Cardiac Events in Hypertrophic Cardiomyopathy.

PubMed

Tsuda, Toyonobu; Hayashi, Kenshi; Konno, Tetsuo; Sakata, Kenji; Fujita, Takashi; Hodatsu, Akihiko; Nagata, Yoji; Teramoto, Ryota; Nomura, Akihiro; Tanaka, Yoshihiro; Furusho, Hiroshi; Takamura, Masayuki; Kawashiri, Masa-Aki; Fujino, Noboru; Yamagishi, Masakazu

2017-10-01

This study sought to investigate whether the presence of J waves was associated with cardiac events in patients with hypertrophic cardiomyopathy (HCM). It has been uncertain whether the presence of J waves predicts life-threatening cardiac events in patients with HCM. This study evaluated consecutive 338 patients with HCM (207 men; age 61 ± 17 years of age). A J-wave was defined as J-point elevation >0.1 mV in at least 2 contiguous inferior and/or lateral leads. Cardiac events were defined as sudden cardiac death, ventricular fibrillation or sustained ventricular tachycardia, or appropriate implantable cardiac defibrillator therapy. The study also investigated whether adding the J-wave in a conventional risk model improved a prediction of cardiac events. J waves were seen in 46 (13.6%) patients at registration. Cardiac events occurred in 31 patients (9.2%) during median follow-up of 4.9 years (interquartile range: 2.6 to 7.1 years). In a Cox proportional hazards model, the presence of J waves was significantly associated with cardiac events (adjusted hazard ratio: 4.01; 95% confidence interval [CI]: 1.78 to 9.05; p = 0.001). Compared with the conventional risk model, the model using J waves in addition to conventional risks better predicted cardiac events (net reclassification improvement, 0.55; 95% CI: 0.20 to 0.90; p = 0.002). The presence of J waves was significantly associated with cardiac events in HCM. Adding J waves to conventional cardiac risk factors improved prediction of cardiac events. Further confirmatory studies are needed before considering J-point elevation as a marker of risk for use in making management decisions regarding risk in patients with HCM. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

New constraints on the TeV SNR shells RX J1713.7-3946 and HESS J1731-347

NASA Astrophysics Data System (ADS)

Puehlhofer, G.; Eger, P.; Doroshenko, V.; Cui, Y.; H. E. S. S. Collaboration

2016-06-01

Resolved TeV-emitting supernova remnants remain a small and precious class of sources to study cosmic ray acceleration in SNRs. We present new multi-wavelength results of the two prominent objects RX J1713.7-3946 and HESS J1731-347. For RX J1713.7-3946, extensive new H.E.S.S. data have permitted to study the nature of the TeV-emitting CR particles through improved broadband spectral studies, as well as through detailed investigations of morphological differences between TeV gamma-rays and X-rays. Concerning HESS J1731-347, the TeV morphology of the object and its surroundings has been studied using cosmic ray acceleration simulations of the object. The SNR also hosts a luminous X-ray emitting central compact object (CCO). Investigations of the CCO in X-rays and in the infrared have permitted to set interesting constraints on the SNR and its progenitor.

Recent results of {chi}{sub cJ} decays from BESIII

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan Liang

2011-05-23

Using (106{+-}4)x10{sup 6} {psi}{sup '} events collected with BESIII/BEPCII in March and April 2009, some {chi}{sub cJ} decay modes are studied, such as {chi}{sub cJ}{yields}{pi}{sup 0}{pi}{sup 0}, {chi}{sub cJ}{yields}{eta}{eta}, {chi}{sub cJ}{yields}VV, {chi}{sub cJ}{yields}{gamma}V, and so on. The precisions of these branching fraction measurements are improved, which is helpful to understand {chi}{sub cJ} decay mechanism.

Diffractive J/Psi Production; Produção Difrativa de $J/psi$ no Experimento DØ (in Portuguese)

DOE Office of Scientific and Technical Information (OSTI.GOV)

dos Santos Assis Jesus, Ana Carolina

This work presents measurements of two diffractive production ratio for heavy flavour physics with the use of a reconstructed J/Ψ → μ +μ - sample in pmore » $$\\bar{p}$$ collisions at √s = 1.96 TeV using the D0 detector at Fermilab Tevatron. These events were selected using the Luminosity Monitor detectors, the calorimeter system and the muon system in a pseudo-rapidity region with range 2.7 ≤ |η| ≤ 4.4. The measured ratio were estimated to be N$$J/Ψ\\atop{diff}$$/N$$J/Ψ\\atop{total}$$ = (1.74 ± 0.16(stat) {+-} 0.13(syst))% e N$$b\\atop{diff}$$/N$$b\\atop{total}$$ = (0.79 ± 0.11(stat) ± 0.23(syst))%.« less

Near-threshold J/ψ-meson photoproduction on nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paryev, E. Ya.; Kiselev, Yu. T., E-mail: yurikis@itep.ru

On the basis of the first-collision model that relies on the nuclear spectral function and which includes incoherent processes involving charmonium production in proton–nucleon collisions, the photoproduction of J/ψ mesons on nuclei is considered at energies close to the threshold for their production on a nucleon. The absorption of final J/ψ mesons, their formation length, and the binding and Fermi motion of target nucleons are taken into account in this model along with the effect of the nuclear potential on these processes. The A dependences of the absolute and relative charmonium yields are calculated together with absolute and relative excitationmore » functions under various assumptions on the magnitude of the cross section for J/ψN absorption, the J/ψ-meson formation length, and their inmedium modification. It is shown that, at energies above the threshold, these features are virtually independent of the formation length and the change in the J/ψ-meson mass in nuclear matter but are rather highly sensitive to the cross section for J/ψN interaction. The calculations performed in the present study can be used to determine the unknown cross section for J/ψ-meson absorption in nuclei from a comparison of their results with data expected from experiments in the Hall C of the CEBAF (USA) facility upgraded to the energy of 12 GeV. It is also shown that the absolute and relative excitation functions for J/ψ mesons in photon–nucleus reactions at subthreshold energies are sensitive to the change in the meson mass and, hence, carry information about the properties of charmonium in nuclear matter.« less

Chronic Intermittent Ethanol Inhalation Increases Ethanol Self-administration in both C57BL/6J and DBA/2J Mice

PubMed Central

McCool, Brian A.; Chappell, Ann M.

2015-01-01

Inbred mouse strains provide significant opportunities to understand the genetic mechanisms controlling ethanol-directed behaviors and neurobiology. They have been specifically employed to understand cellular mechanisms contributing to ethanol consumption, acute intoxication, and sensitivities to chronic effects. However, limited ethanol consumption by some strains has restricted our understanding of clinically relevant endpoints such as dependence-related ethanol intake. Previous work with a novel tastant-substitution procedure using monosodium glutamate (MSG or umami flavor) has shown that the procedure greatly enhances ethanol consumption by mouse strains that express limited drinking phenotypes using other methods. In the current study, we employ this MSG-substitution procedure to examine how ethanol dependence, induced with passive vapor inhalation, modifies ethanol drinking in C57BL/6J and DBA/2J mice. These strains represent ‘high’ and ‘low’ drinking phenotypes, respectively. We found that the MSG substitution greatly facilitates ethanol drinking in both strains, and likewise, ethanol dependence increased ethanol consumption regardless of strain. However, DBA/2J mice exhibited greater sensitivity dependence-enhanced drinking, as represented by consumption behaviors directed at lower ethanol concentrations and relative to baseline intake levels. DBA/2J mice also exhibited significant withdrawal-associated anxiety-like behavior while C57BL/6J mice did not. These findings suggest that the MSG-substitution procedure can be employed to examine dependence-enhanced ethanol consumption across a range of drinking phenotypes, and that C57BL/6J and DBA/2J mice may represent unique neurobehavioral pathways for developing dependence-enhanced ethanol consumption. PMID:25659650

Chronic intermittent ethanol inhalation increases ethanol self-administration in both C57BL/6J and DBA/2J mice.

PubMed

McCool, Brian A; Chappell, Ann M

2015-03-01

Inbred mouse strains provide significant opportunities to understand the genetic mechanisms controlling ethanol-directed behaviors and neurobiology. They have been specifically employed to understand cellular mechanisms contributing to ethanol consumption, acute intoxication, and sensitivities to chronic effects. However, limited ethanol consumption by some strains has restricted our understanding of clinically relevant endpoints such as dependence-related ethanol intake. Previous work with a novel tastant-substitution procedure using monosodium glutamate (MSG or umami flavor) has shown that the procedure greatly enhances ethanol consumption by mouse strains that express limited drinking phenotypes using other methods. In the current study, we employ this MSG-substitution procedure to examine how ethanol dependence, induced with passive vapor inhalation, modifies ethanol drinking in C57BL/6J and DBA/2J mice. These strains represent 'high' and 'low' drinking phenotypes, respectively. We found that the MSG substitution greatly facilitates ethanol drinking in both strains, and likewise, ethanol dependence increased ethanol consumption regardless of strain. However, DBA/2J mice exhibited greater sensitivity dependence-enhanced drinking, as represented by consumption behaviors directed at lower ethanol concentrations and relative to baseline intake levels. DBA/2J mice also exhibited significant withdrawal-associated anxiety-like behavior while C57BL/6J mice did not. These findings suggest that the MSG-substitution procedure can be employed to examine dependence-enhanced ethanol consumption across a range of drinking phenotypes, and that C57BL/6J and DBA/2J mice may represent unique neurobehavioral pathways for developing dependence-enhanced ethanol consumption. Copyright © 2015 Elsevier Inc. All rights reserved.

What is French for déjà vu? Descriptions of déjà vu in native French and English speakers.

PubMed

Fortier, Jonathan; Moulin, Chris J A

2015-11-01

Little is known about how people characterise and classify the experience of déjà vu. The term déjà vu might capture a range of different phenomena and people may use it differently. We examined the description of déjà vu in two languages: French and English, hypothesising that the use of déjà vu would vary between the two languages. In French, the phrase déjà vu can be used to indicate a veridical experience of recognition - as in "I have already seen this face before". However, the same is not true in English. In an online questionnaire, we found equal rates of déjà vu amongst French and English speakers, and key differences in how the experience was described. As expected, the French group described the experience as being more frequent, but there was the unexpected finding that they found it to be more troubling. Copyright © 2015 Elsevier Inc. All rights reserved.

Is the CMS e e j j excess a hint for light supersymmetry?

NASA Astrophysics Data System (ADS)

Krauss, Manuel E.; Porod, Werner

2015-09-01

We discuss the impact of additional two-body decays of the right-handed neutrino into a light charged Higgs state on the dilepton plus dijet cross sections from resonant W' production. We consider in particular a supersymmetric left-right symmetric model which predicts such a light charged Higgs boson. We demonstrate that the e e j j excess as measured by CMS can be explained best if the W' also has decay modes into Higgsino-like charginos and neutralinos with masses of a few hundred GeV. Provided that this excess is confirmed, the model predicts also one right-handed neutrino with a mass below 200 GeV as well as a doubly charged Higgs boson which should be discovered at the LHC in the near future.

Study of B+/ --> J/psi pi+/- and B+/ -->J/psi K+/- decays: measurement of the ratio of branching fractions and search for direct CP violation.

PubMed

Aubert, B; Barate, R; Boutigny, D; Couderc, F; Gaillard, J-M; Hicheur, A; Karyotakis, Y; Lees, J P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; LeClerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Morgan, S E; Watson, A T; Watson, N K; Fritsch, M; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Steinke, M; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; Wilson, F F; Abe, K; Cuhadar-Donszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Eschrich, I; Kirkby, D; Lankford, A J; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Gary, J W; Shen, B C; Wang, K; del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, Sh; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Smith, J G; van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Feltresi, E; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, J; Schubert, K R; Schwierz, R; Spaan, B; Bernard, D; Bonneaud, G R; Brochard, F; Grenier, P; Thiebaux, Ch; Vasileiadis, G; Verderi, M; Bard, D J; Khan, A; Lavin, D; Muheim, F; Playfer, S; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Sarti, A; Treadwell, E; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Patteri, P; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Brandenburg, G; Morii, M; Won, E; Dubitzky, R S; Langenegger, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Gaillard, J R; Morton, G W; Nash, J A; Taylor, G P; Grenier, G J; Lee, S-J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Cheng, C H; Lange, D J; Simani, M C; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, E; Gamet, R; Kay, M; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Harrison, P F; Mohanty, G B; Brown, C L; Cowan, G; Flack, R L; Flaecher, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Hart, P A; Hodgkinson, M C; Lafferty, G D; Lyon, A J; Williams, J C; Farbin, A; Hulsbergen, W D; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Staengle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M; Raven, G; Wilden, L; Jessop, C P; LoSecco, J M; Gabriel, T A; Allmendinger, T; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Ter-Antonyan, R; Wong, Q K; Brau, J; Frey, R; Igonkina, O; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; de laVassière, Ch; Del Buono, L; Hamon, O; John, M J J; Leruste, Ph; Ocariz, J; Pivk, M; Roos, L; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Anulli, F; Biasini, M; Peruzzi, I M; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Del Gamba, V; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martinez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lu, C; Miftakov, V; Olsen, J; Smith, A J S; Varnes, E W; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Safai Tehrani, F; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P-F; Hamel de Monchenault, G; Kozanecki, W; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yèche, Ch; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmueller, O L; Convery, M R; Cristinziani, M; De Nardo, G; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Elsen, E E; Field, R C; Glanzman, T; Gowdy, S J; Hadig, T; Halyo, V; Hryn'ova, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Libby, J; Luitz, S; Luth, V; Lynch, H L; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Va'vra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Young, C C; Burchat, P R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, S; Alam, M S; Ernst, J A; Saeed, M A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Satpathy, A; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bona, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Hollar, J J; Johnson, J R; Kutter, P E; Li, H; Liu, R; Di Lodovico, F; Mihalyi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; Tan, P; von Wimmersperg-Toeller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H

2004-06-18

We study B+/ --> J/psi pi(+/-) and B+/ --> J/psi K+/- decays in a sample of about 89 x 10(6) BB pairs collected with the BABAR detector at the PEP-II asymmetric B factory at SLAC. We observe a signal of 244+/-20 B+/ --> J/psi pi(+/-) events and determine the ratio B(B+/ --> J/psi pi(+/-))/B(B+/ --> J/psi K+/-) to be [5.37+/-0.45(stat)+/-0.11(syst)]%. The charge asymmetries for the B+/ --> J/psi pi(+/-) and B+/ --> J/psi K+/- decays are determined to be A(pi)=0.123+/-0.085(stat)+/-0.004(syst) and A(K)=0.030+/-0.015(stat)+/-0.006(syst), respectively.

Explaining a CMS e e j j excess with R -parity violating supersymmetry and implications for neutrinoless double beta decay

NASA Astrophysics Data System (ADS)

Allanach, Ben; Biswas, Sanjoy; Mondal, Subhadeep; Mitra, Manimala

2015-01-01

A recent CMS search for the right-handed gauge boson WR reports an interesting deviation from the Standard Model. The search has been conducted in the e e j j channel and has shown a 2.8 σ excess around me e j j˜2 TeV . In this work, we explain the reported CMS excess with R -parity violating supersymmetry. We consider resonant selectron and sneutrino production, followed by the three body decays of the neutralino and chargino via an R -parity violating coupling. We fit the excess for slepton masses around 2 TeV. The scenario can further be tested in neutrinoless double beta decay (0 ν β β ) experiments. GERDA Phase-II will probe a significant portion of the good-fit parameter space.

Effect of ECG filter settings on J-waves.

PubMed

Nakagawa, Mikiko; Tsunemitsu, Chie; Katoh, Sayo; Kamiyama, Yukari; Sano, Nario; Ezaki, Kaori; Miyazaki, Hiroko; Teshima, Yasushi; Yufu, Kunio; Takahashi, Naohiko; Saikawa, Tetsunori

2014-01-01

While J-waves were observed in healthy populations, variations in their reported incidence may be partly explicable by the ECG filter setting. We obtained resting 12-lead ECG recordings in 665 consecutive patients and enrolled 112 (56 men, 56 women, mean age 59.3±16.1years) who manifested J-waves on ECGs acquired with a 150-Hz low-pass filter. We then studied the J-waves on individual ECGs to look for morphological changes when 25-, 35-, 75-, 100-, and 150Hz filters were used. The notching observed with the 150-Hz filter changed to slurring (42%) or was eliminated (28%) with the 25-Hz filter. Similarly, the slurring seen with the 150-Hz filter was eliminated on 71% of ECGs recorded with the 25-Hz filter. The amplitude of J-waves was significantly lower with 25- and 35-Hz than 75-, 100-, and 150-Hz filters (p<0.0001). The ECG filter setting significantly affects the J-wave morphology. © 2013.

Spectroscopy of PSN J19583553+0236163

NASA Astrophysics Data System (ADS)

Leonard, D. C.; Moustakas, J.; Swift, B. J.; McCarthy, D.; Bailey, V.; Carrico, E.; Carter, A.; Chui, E.; Douglas, E.; Eggeman, E.; Goldberg, R.; Grant, R.; Hartman, K.; Hellerstein, J.; Hooper, E.; Horlick-Cruz, C.; Hunter, L.; Jiles, T.; Johnson, E. D.; Kumar, K.; Lappe, L.; Lee, J.; Lee, W.; Marsh, F.; Mehta, G.; Miller, P.; Rampalli, R.; Reed, J.; Rice, K.; Saldivar, H.; Salgado-Flores, M.; Schlingman, A.; Schlingman, W. F.; Schlingman, W. M.; Scibelli, S.; Sinclair, K.; Steincamp, I.; Stock, N.; Todd, N.; Vargas, L. L. Aizpuru; Yamanaka, S.; Zachary, E.

2011-06-01

As part of the 2011 Advanced Teen Astronomy Camp (http://www.astronomycamp.org), we obtained a low dispersion optical spectrum (range 370-690 nm) of PSN J19583553+0236163 in UGC 11501 with the 2.3m Bok telescope (+ Boller & Chivens spectrograph) at Steward Observatory, on 2011 June 23 UT. Cross-correlation with a library of supernova spectra using the Supernova Identification code (SNID; Blondin and Tonry 2007, Ap.J.

Overview of the Neutron Radiography and Computed Tomography at the Oak Ridge National Laboratory and Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bilheux, Hassina Z; Bilheux, Jean-Christophe; Tremsin, Anton S

2015-01-01

The Oak Ridge National Laboratory (ORNL) Neutron Sciences Directorate (NScD) has installed a neutron imaging (NI) beam line at the High Flux Isotope Reactor (HFIR) cold guide hall. The CG-1D beam line produces cold neutrons for a broad range of user research spanning from engineering to material research, additive manufacturing, vehicle technologies, archaeology, biology, and plant physiology. Recent efforts have focused on increasing flux and spatial resolution. A series of selected engineering applications is presented here. Historically and for more than four decades, neutron imaging (NI) facilities have been installed exclusively at continuous (i.e. reactor-based) neutron sources rather than atmore » pulsed sources. This is mainly due to (1) the limited number of accelerator-based facilities and therefore the fierce competition for beam lines with neutron scattering instruments, (2) the limited flux available at accelerator-based neutron sources and finally, (3) the lack of high efficiency imaging detector technology capable of time-stamping pulsed neutrons with sufficient time resolution. Recently completed high flux pulsed proton-driven neutron sources such as the ORNL Spallation Neutron Source (SNS) at ORNL and the Japanese Spallation Neutron Source (JSNS) of the Japan Proton Accelerator Research Complex (J-PARC) in Japan produce high neutron fluxes that offer new and unique opportunities for NI techniques. Pulsed-based neutron imaging facilities RADEN and IMAT are currently being built at J-PARC and the Rutherford National Laboratory in the U.K., respectively. ORNL is building a pulsed neutron imaging beam line called VENUS to respond to the U.S. based scientific community. A team composed of engineers, scientists and designers has developed a conceptual design of the future VENUS imaging instrument at the SNS.« less

FibrilJ: ImageJ plugin for fibrils' diameter and persistence length determination

NASA Astrophysics Data System (ADS)

Sokolov, P. A.; Belousov, M. V.; Bondarev, S. A.; Zhouravleva, G. A.; Kasyanenko, N. A.

2017-05-01

Application of microscopy to evaluate the morphology and size of filamentous proteins and amyloids requires new and creative approaches to simplify and automate the image processing. The estimation of mean values of fibrils diameter, length and bending stiffness on micrographs is a major challenge. For this purpose we developed an open-source FibrilJ plugin for the ImageJ/FiJi program. It automatically recognizes the fibrils on the surface of a mica, silicon, gold or formvar film and further analyzes them to calculate the distribution of fibrils by diameters, lengths and persistence lengths. The plugin has been validated by the processing of TEM images of fibrils formed by Sup35NM yeast protein and artificially created images of rod-shape objects with predefined parameters. Novel data obtained by SEM for Sup35NM protein fibrils immobilized on silicon and gold substrates are also presented and analyzed.

Transient simulation of a miniature Joule-Thomson (J-T) cryocooler with and without the distributed J-T effect

NASA Astrophysics Data System (ADS)

Damle, R. M.; Atrey, M. D.

2015-01-01

The aim of this work is to develop a transient program for the simulation of a miniature Joule-Thomson (J-T) cryocooler to predict its cool-down characteristics. A one dimensional transient model is formulated for the fluid streams and the solid elements of the recuperative heat exchanger. Variation of physical properties due to pressure and temperature is considered. In addition to the J-T expansion at the end of the finned tube, the distributed J-T effect along its length is also considered. It is observed that the distributed J-T effect leads to additional cooling of the gas in the finned tube and that it cannot be neglected when the pressure drop along the length of the finned tube is large. The mathematical model, method of resolution and the global transient algorithm, within a modular object-oriented framework, are detailed in this paper. As a part of verification and validation of the developed model, cases available in the literature are simulated and the results are compared with the corresponding numerical and experimental data.

Fluoroquinolone Resistance in Streptococcus dysgalactiae subsp. equisimilis and Evidence for a Shared Global Gene Pool with Streptococcus pyogenes▿

PubMed Central

Pinho, M. D.; Melo-Cristino, J.; Ramirez, M.

2010-01-01

Quinolone resistance is an emerging problem in Streptococcus pyogenes, and recombination with Streptococcus dysgalactiae DNA has been implicated as a frequent mechanism leading to resistance. We have characterized a collection of S. dysgalactiae subsp. equisimilis isolates responsible for infections in humans (n = 314) and found a high proportion of levofloxacin-resistant isolates (12%). Resistance was associated with multiple emm types and genetic lineages, as determined by pulsed-field gel electrophoretic profiling. Since we could not find evidence for a role of efflux pumps in resistance, we sequenced the quinolone resistance-determining regions of the gyrA and parC genes of representative resistant and susceptible isolates. We found much greater diversity among the parC genes (19 alleles) than among the gyrA genes (5 alleles). While single mutations in either GyrA or ParC were sufficient to raise the MIC so that the strains were classified as intermediately resistant, higher-level resistance was associated with mutations in both GyrA and ParC. Evidence for recombination with S. pyogenes DNA was found in some parC alleles, but this was not exclusively associated with resistance. Our data support the existence of a common reservoir of genes conferring quinolone resistance shared between S. dysgalactiae subsp. equisimilis and S. pyogenes, while no recombination with the animal pathogen S. dysgalactiae subsp. dysgalactiae could be found. PMID:20145082

Early phenotypical diagnoses in Trembler-J mice model.

PubMed

Rosso, Gonzalo; Cal, Karina; Canclini, Lucía; Damián, Juan Pablo; Ruiz, Paul; Rodríguez, Héctor; Sotelo, José Roberto; Vazquez, Cristina; Kun, Alejandra

2010-06-30

Pmp-22 mutant mice (Trembler-J: B6.D2-Pmp22J>/J), are used as a model to study Charcot-Marie-Tooth type 1A (CMT1A). The identification of individual genotypes is a routine in the management of the Tr(J) colony. The earliest phenotypic manifestation of the pmp-22 mutation is just about 20th postnatal days, when pups begin to tremble. In this study, a rapid and simple diagnostic method was developed by modifying the Tail Suspension Test (MTST) to determine the difference between the Tr(J) and the wild-type mice phenotype. The animal behavioral phenotypes generated during the test were consistent with the specific genotype of each animal. The MTST allowed us to infer the heterozygous genotype in early postnatal stages, at 11 days after birth. The motor impairment of Tr(J) mice was also analyzed by a Fixed Bar Test (FBT), which revealed the disease evolution according to age. The main advantages of MTST are its objectivity, simplicity, and from the viewpoint of animal welfare, it is a non-invasive technique that combined with his rapidity show its very well applicability for use from an early age in these mice. Copyright 2010 Elsevier B.V. All rights reserved.

Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line.

PubMed

Bryant, Camron D; Kole, Loren A; Guido, Michael A; Cheng, Riyan; Palmer, Abraham A

2012-01-01

The conditioned place preference (CPP) test is frequently used to evaluate the rewarding properties of drugs of abuse in mice. Despite its widespread use in transgenic and knockout experiments, there are few forward genetic studies using CPP to identify novel genes contributing to drug reward. In this study, we tested LG/J and SM/J inbred strains and the parents/offspring of 10 families of an F(45)/F(46) advanced intercross line (AIL) for methamphetamine-induced CPP (MA-CPP) once per week over 2 weeks. Both LG/J and SM/J mice exhibited significant MA-CPP that was not significantly different between the two strains. Furthermore, LG/J mice showed significantly less acute MA-induced locomotor activity as well as locomotor sensitization following subsequent MA injections. AIL mice (N = 105) segregating LG/J and SM/J alleles also demonstrated significant MA-CPP that was equal in magnitude between the first and second week of training. Importantly, MA-CPP in AIL mice did not correlate with drug-free or MA-induced locomotor activity, indicating that MA-CPP was not confounded by test session activity and implying that MA-CPP is genetically distinct from acute psychomotor sensitivity. We estimated the heritability of MA-CPP and locomotor phenotypes using midparent-offspring regression and maximum likelihood estimates derived from the kinship coefficients of the AIL pedigree. Heritability estimates of MA-CPP were low (0-0.21) and variable (SE = 0-0.33) which reflected our poor power to estimate heritability using only 10 midparent-offspring observations. In sum, we established a short-term protocol for MA-CPP in AIL mice that could reveal LG/J and SM/J alleles important for MA reward. The use of highly recombinant genetic populations like AIL should facilitate the identification of these genes and may have implications for understanding psychostimulant abuse in humans.

Partial dispensability of Djp1's J domain in peroxisomal protein import in Saccharomyces cerevisiae results from genetic redundancy with another class II J protein, Caj1.

PubMed

Dobriyal, Neha; Tripathi, Prerna; Sarkar, Susrita; Tak, Yogesh; Verma, Amit K; Sahi, Chandan

2017-05-01

J proteins are obligate co-chaperones of Hsp70s. Via their signature J domain, all J proteins interact with their partner Hsp70s and stimulate their weak ATPase activity, which is vital for Hsp70 functions. The dependency of J proteins on their J domain is such that mutations in critical amino acids in the J domain often results into a null phenotype for a particular J protein. Here, we show that the J domain of Djp1, a cytosolic J protein important for peroxisomal protein import in Saccharomyces cerevisiae, is partially dispensable. A complete deletion of Djp1 J domain resulted into only partial loss in peroxisomal protein import function. Instead, the C-terminal domain of Djp1 was found to be essential for proper localization of the peroxisomal targeted GFP-PTS1. Furthermore, we show that Caj1, another cytosolic J protein, also has some role in peroxisomal protein import. Caj1 was found to be partially redundant with Djp1 as cells lacking both Djp1 and Caj1 resulted into a much more severe defect in GFP-PTS1 localization. Based on these results, we propose that dispensability of J domains could be attributed to genetic redundancy between different J proteins sharing common structural topology and cellular localization.

FERMI LARGE AREA TELESCOPE DETECTION OF PULSED gamma-RAYS FROM THE VELA-LIKE PULSARS PSR J1048-5832 AND PSR J2229+6114

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, A. A.; Ackermann, M.; Ajello, M.

2009-12-01

We report the detection of gamma-ray pulsations (>=0.1 GeV) from PSR J2229+6114 and PSR J1048-5832, the latter having been detected as a low-significance pulsar by EGRET. Data in the gamma-ray band were acquired by the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope, while the radio rotational ephemerides used to fold the gamma-ray light curves were obtained using the Green Bank Telescope, the Lovell telescope at Jodrell Bank, and the Parkes Telescope. The two young radio pulsars, located within the error circles of the previously unidentified EGRET sources 3EG J1048-5840 and 3EG J2227+6122, present spin-down characteristics similar tomore » the Vela pulsar. PSR J1048-5832 shows two sharp peaks at phases 0.15 +- 0.01 and 0.57 +- 0.01 relative to the radio pulse confirming the EGRET light curve, while PSR J2229+6114 presents a very broad peak at phase 0.49 +- 0.01. The gamma-ray spectra above 0.1 GeV of both pulsars are fit with power laws having exponential cutoffs near 3 GeV, leading to integral photon fluxes of (2.19 +- 0.22 +- 0.32) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J1048-5832 and (3.77 +- 0.22 +- 0.44) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J2229+6114. The first uncertainty is statistical and the second is systematic. PSR J1048-5832 is one of the two LAT sources which were entangled together as 3EG J1048-5840. These detections add to the growing number of young gamma-ray pulsars that make up the dominant population of GeV gamma-ray sources in the Galactic plane.« less

CYP101J2, CYP101J3, and CYP101J4, 1,8-Cineole-Hydroxylating Cytochrome P450 Monooxygenases from Sphingobium yanoikuyae Strain B2

PubMed Central

Unterweger, Birgit; Bulach, Dieter M.; Scoble, Judith; Midgley, David J.; Greenfield, Paul; Lyras, Dena; Johanesen, Priscilla

2016-01-01

ABSTRACT We report the isolation and characterization of three new cytochrome P450 monooxygenases: CYP101J2, CYP101J3, and CYP101J4. These P450s were derived from Sphingobium yanoikuyae B2, a strain that was isolated from activated sludge based on its ability to fully mineralize 1,8-cineole. Genome sequencing of this strain in combination with purification of native 1,8-cineole-binding proteins enabled identification of 1,8-cineole-binding P450s. The P450 enzymes were cloned, heterologously expressed (N-terminally His6 tagged) in Escherichia coli BL21(DE3), purified, and spectroscopically characterized. Recombinant whole-cell biotransformation in E. coli demonstrated that all three P450s hydroxylate 1,8-cineole using electron transport partners from E. coli to yield a product putatively identified as (1S)-2α-hydroxy-1,8-cineole or (1R)-6α-hydroxy-1,8-cineole. The new P450s belong to the CYP101 family and share 47% and 44% identity with other 1,8-cineole-hydroxylating members found in Novosphingobium aromaticivorans and Pseudomonas putida. Compared to P450cin (CYP176A1), a 1,8-cineole-hydroxylating P450 from Citrobacter braakii, these enzymes share less than 30% amino acid sequence identity and hydroxylate 1,8-cineole in a different orientation. Expansion of the enzyme toolbox for modification of 1,8-cineole creates a starting point for use of hydroxylated derivatives in a range of industrial applications. IMPORTANCE CYP101J2, CYP101J3, and CYP101J4 are cytochrome P450 monooxygenases from S. yanoikuyae B2 that hydroxylate the monoterpenoid 1,8-cineole. These enzymes not only play an important role in microbial degradation of this plant-based chemical but also provide an interesting route to synthesize oxygenated 1,8-cineole derivatives for applications as natural flavor and fragrance precursors or incorporation into polymers. The P450 cytochromes also provide an interesting basis from which to compare other enzymes with a similar function and expand the CYP101

Verticalization of behavior elicited by dopaminergic mobilization is qualitatively different between C57BL/6J and DBA/2J mice.

PubMed

Tirelli, E; Witkin, J M

1994-10-01

Behavioral effects of dopaminergic stimulation were evaluated in C57BL/6J mice and compared to the effects occurring in DBA/2J mice, an inbred strain with reduced densities of striatal dopamine receptors. Effects of apomorphine (0.5-64 mg/kg) alone and in combination with cocaine (30 mg/kg) were assessed using a time-sampling technique that classified climbing and leaning in separate categories. Locomotion was also assessed in a separate experiment. Climbing occurred in DBA/2J mice only at doses of apomorphine that were 16 times higher than the smallest effective dose in C57BL/6J mice; nevertheless, relative to baseline values, effects were fairly comparable. By contrast, whereas DBA/2J mice showed dose-dependent leaning under apomorphine, C57BL/6J mice exhibited little leaning even at doses not producing climbing, and only after the highest apomorphine dose was leaning significantly increased. Apomorphine was equipotent in inducing gnawing across strains, although somewhat less efficacious in DBA/2J mice. When given alone, cocaine produced significant climbing, but not leaning or gnawing, in either strain. Whereas cocaine potentiated apomorphine-induced climbing and gnawing in both strains, apomorphine-induced leaning was not consistently changed by cocaine in either strain. These effects were not indirectly due to hyperkinesia, since neither apomorphine alone nor apomorphine and cocaine in combination was stimulant; apomorphine alone reduced locomotor activity and attenuated cocaine-induced hyperkinesia. The present data do not support a unitary, purely quantitative, account of insensitivity to dopaminergic stimulation based upon low densities of striatal dopamine receptors in DBA/2J mice. Rather, this constellation of results is suggestive of qualitative interstrain dissimilarities in dopaminergic responsiveness that could reflect organizational differences in receptor populations.

Clinical significance of J-wave in elite athletes.

PubMed

Pelliccia, Antonio; Quattrini, Filippo M

2015-01-01

The J-wave pattern on 12-lead ECG is traditionally defined as a positive deflection at junction between the end of the QRS and the beginning of the ST-segment. This pattern has recently been associated with increased risk for idiopathic ventricular fibrillation in the absence of cardiovascular disease. The interest for the clinical significance of J-wave pattern as a potential ECG hallmark of high risk for cardiac arrest has recently been reinforced by the growing practice of ECG screening, such as occurs in large population of young competitive athletes. The available scientific evidence shows that the J-wave pattern is relatively common in trained athletes (ranging from 14% to 44%) and, differently from subjects who suffered from ventricular fibrillation, commonly localized in lateral leads while it is relatively rare to be found in inferior leads. Furthermore the J-wave pattern has been demonstrated to be a dynamic phenomenon related to the training status, with the larger prominence at the peak of training and with an inverse relation between magnitude of J-wave and heart rate. In addition the J-wave pattern is usually associated with other ECG changes, such as increased QRS voltages and ST-segment elevation, as well as LV remodeling, suggesting that it likely represents another expression of the physiologic athlete's heart. Finally the scientific data available demonstrated that during a medium follow-up period the J-wave pattern does not convey risk for adverse cardiac events, including sudden death or ventricular tachyarrhythmias. Copyright © 2015 Elsevier Inc. All rights reserved.

J85 Rejuvenation Through Technology Insertion

DTIC Science & Technology

2000-10-01

and Sabre 75 business addition to military production, the J85 was jets . Number Model Produced Aircraft Type(s) Engine Type Thrust (lbs) J85-GE-4 740...REJUVENATION THROUGH TECHNOLOGY INSERTION T.A. Brisken, P.N. Howell, A.C. Ewing Military Engines Operation GE Aircraft Engines 1 Neumann Way Cincinnati...OH 45215, USA Summary thrust to weight ratio turbojet engines with potential application to early cruise missiles and drones. The history of the

LAUNCH - STS-28/51J - KSC

NASA Image and Video Library

1985-11-20

S85-44776 (3 Oct 1985) --- Space Shuttle Atlantis soars toward Florida blue skies to mark the maiden mission of NASA's fourth and newest orbiter vehicle. Launch occurred at 11:15 a.m. (EDT), October 3, 1985. A five member crew mans the orbiter for the DOD flight. They are Karol J. Bobko, Ronald J. Grabe, Robert L. Stewart, David C. Hilmers-- all of NASA-- and William A. Pailes of the USAF.

7 CFR Appendix J to Subpart E of... - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true [Reserved] J Appendix J to Subpart E of Part 1980 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) GENERAL Business and Industrial Loan Program Appendix J to Subpart E of...

Supersymmetry and Kaon physics

NASA Astrophysics Data System (ADS)

Yamamoto, Kei

2017-01-01

Kaon physics has played an essential role in testing the Standard Model and in searching for new physics with measurements of CP violation and rare decays. Current progress of lattice calculations enables us to predict kaon observables accurately, especially for the direct CP violation, ε‧/ε, and there is a discrepancy from the experimental data at the 2.9 σ level. On the experimental side, the rare kaon decays and are ongoing to be measured at the SM accuracy by KOTO at J-PARC and NA62 at CERN. These kaon observables are good probes for new physics. We study supersymmetric effects; the chargino and gluino contributions to Z penguin, in kaon observables.

Nuclear-bound quarkonia and heavy-flavor hadrons

NASA Astrophysics Data System (ADS)

Krein, G.; Thomas, A. W.; Tsushima, K.

2018-05-01

In our quest to win a deeper understanding of how QCD actually works, the study of the binding of heavy quarkonia and heavy-flavor hadrons to atomic nuclei offers enormous promise. Modern experimental facilities such as FAIR, Jefferson Lab at 12 GeV and J-PARC offer exciting new experimental opportunities to study such systems. These experimental advances are complemented by new theoretical approaches and predictions, which will both guide these experimental efforts and be informed and improved by them. This review will outline the main theoretical approaches, beginning with QCD itself, summarize recent theoretical predictions and relate them both to past experiments and those from which we may expect results in the near future.

Isotopic composition of a sample enriched in 93Zr

DOE PAGES

Fujii, Toshiyuki; Hori, Jun-ichi; Du, Miting; ...

2015-10-22

A project to determine the neutron-capture cross section of long lived fission products and minor actinides has been started by using a beam-line at Japan Proton Accelerator Research Complex (J-PARC). We prepared one of the target nuclides is Zr-93, which in Oak Ridge National Laboratory. Qualitative and quantitative analyses on the sample were performed at Kyoto University. The isotopic composition of (m) Zr (m 90, 91, 92, 93, 94, and 96) was precisely determined by multi-collector thermal ionization mass spectrometry with < 0.1 % of 2 sigma uncertainty. We determined that the atomic abundance of Zr-93 in the sample tomore » be 18.86 ± A 0.05 %.« less

29 CFR 451.4 - Labor organizations under section 3(j).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Labor organizations under section 3(j). 451.4 Section 451.4... 1959 § 451.4 Labor organizations under section 3(j). (a) General. Section 3(j) sets forth five... one of these categories listed in section 3(j) is subject to the requirements of the Act. (b...

J-2X engine

NASA Image and Video Library

2012-05-16

On May 16, 2012, engineers at Stennis Space Center conducted a test of the next-generation J-2X engine that will help power NASA's new Space Launch System, moving NASA even closer to a return to deep space.

Protein Microarray Analysis in Patients With Asthma*

PubMed Central

Kim, Hyo-Bin; Kim, Chang-Keun; Iijima, Koji; Kobayashi, Takao; Kita, Hirohito

2010-01-01

Background Microarray technology offers a new opportunity to gain insight into global gene and protein expression profiles in asthma. To identify novel factors produced in the asthmatic airway, we analyzed sputum samples by using a membrane-based human cytokine microarray technology in patients with bronchial asthma (BA). Methods Induced sputum was obtained from 28 BA subjects, 20 nonasthmatic atopic control (AC) subjects, and 38 nonasthmatic nonatopic normal control (NC) subjects. The microarray samples of subjects were randomly selected from nine BA subjects, three AC subjects, and six NC subjects. Sputum supernatants were analyzed using a custom human cytokine array (RayBio Custom Human Cytokine Array; RayBiotech; Norcross, GA) designed to analyze 79 specific cytokines simultaneously. The levels of growth-regulated oncogene (GRO)-α, eotaxin-2, and pulmonary and activation-regulated chemokine (PARC)/CCL18 were measured by sandwich enzyme-linked immunosorbent assays (ELISAs), and eosinophil-derived neurotoxin (EDN) was measured by radioimmunoassay. Results By microarray, the signal intensities for GRO-α, eotaxin-2, and PARC were significantly higher in BA subjects than in AC and NC subjects (p = 0.036, p = 0.042, and p = 0.033, respectively). By ELISA, the sputum PARC protein levels were significantly higher in BA subjects than in AC and NC subjects (p < 0.0001). Furthermore, PARC levels correlated significantly with sputum eosinophil percentages (r = 0.570, p < 0.0001) and the levels of EDN(r = 0.633, p < 0.0001), the regulated upon activation, normal T cell expressed and secreted cytokine (r = 0.440, p < 0.001), interleukin-4 (r = 0.415, p < 0.01), and interferon-γ (r = 0.491, p < 0.001). Conclusions By a nonbiased screening approach, a chemokine, PARC, is elevated in sputum specimens from patients with asthma. PARC may play important roles in development of airway eosinophilic inflammation in asthma. PMID:19017877

Exosomes carring gag/env of ALV-J possess negative effect on immunocytes.

PubMed

Wang, Guihua; Wang, Zhenzhen; Zhuang, Pingping; Zhao, Xiaomin; Cheng, Ziqiang

2017-11-01

J subgroup avian leukosis virus (ALV-J) is an exogenous retrovirus of avian. A key feature of ALV-J infection is leading to severe immunosuppressive characteristic of diseases. Viral components of retrovirus were reported closely associated with immunosuppression, and several similarities between exosomes and retrovirus preparations have lead to the hypotheses of retrovirus hijacker exosomes pathway. In this study, we purified exosomes from DF-1 cells infected and uninfected by ALV-J. Electron microscopy and mass spectrometry (MS) analysis showed that ALV-J not only increased the production of exosomes from ALV-J infected DF-1 cells (Exo-J) but also stimulated some proteins expression, especially ALV-J components secreted in exosomes. Immunosuppressive domain peptide (ISD) of envelope subunit transmembrane (TM) and gag of ALV-J were secreted in Exo-J. It has been reported that HIV gag was budded from endosome-like domains of the T cell plasma membrane. But env protein was first detected in exosomes from retrovirus infected cells. We found that Exo-J caused negative effects on splenocytes in a dose-dependant manner by flow cytometric analysis. And low dose of Exo-J activated immune activity of splenocytes, while high dose possessed immunosuppressive properties. Interestingly, Exo-J has no significant effects on the immunosuppression induced by ALV-J, and the immunosuppressive effects induced by Exo-J lower than that by ALV-J. Taken together, our data indicated that Exo-J supplied a microenvironment for the replication and transformation of ALV-J. Copyright © 2017. Published by Elsevier Ltd.

Re J (A Minor) (Wardship: Medical Treatment)

PubMed

1992-06-10

The Civil Division of England's Court of Appeal overturned the lower court's order of mechanical ventilation for a profoundly handicapped sixteen-month-old child against the clinical judgment of the child's doctors. Since hitting his head in a fall at age four weeks, J had not mentally developed past that time and he was blind and he suffered from severe cerebral palsy and epilepsy. He required nasogastric tubal feeding and, although he occasionally responded to sound, whether or not he recognized his caregivers was uncertain. His divorced mother and the local authority shared parental authority over J, who resided with foster parents. The consultant pediatrician reported that if J were to suffer a life-threatening event, ordinary resuscitation, antibiotics and physiotherapy would be appropriate, but intervention with intensive measures including mechanical ventilation would be medically inappropriate. Two other specialists agreed with those findings, but another consultant found mechanical ventilation not to be cruel and thought J could be weaned from it if it became so. The mother and local health authority asked the court to require the health authority to continue all treatment, including mechanical ventilation, of J. The Official Solicitor and the health authority opposed such an order. The lower court granted an interim order requiring mechanical ventilation if necessary over the five weeks prior to the main hearing. The appellate court viewed such an order as an abuse of judicial power and held that the physician's duty to the patient is to treat with the necessary consent in accord with the best clinical judgment and that, as long as those with parental authority consent to J's treatment by the health authority, he must be treated in accord with the best clinical judgment of that authority's personnel.

J functions for the process ud→WA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bardin, D. Yu., E-mail: bardin@nu.jinr.ru; Kalinovskaya, L. V., E-mail: kalinov@mail.cern.ch; Uglov, E. D., E-mail: e.uglov@gmail.com

In this paper we present a description of the universal approach for analytic calculations for a certain class of J functions for six topologies of the boxes for the process ud → WA. These functions J arise at the reduction of the infrared divergent box diagrams. The standard Passarino–Veltman reduction of the four-point box diagram with an internal photon line connecting two external lines on the mass shell leads to infrared-divergent and mass-singular D{sub 0} functions. In the system SANC a systematic procedure is adopted to separate both types of singularities into the simplest objects, namely C{sub 0} functions. Themore » functions J, in turn, are represented as certain linear combinations of the standard D{sub 0} and C{sub 0} functions. The subtracted J functions are free of both types of singularities and are expressed as explicit and compact linear combinations of dilogarithm functions. We present extensive comparisons of numerical results of SANC with those obtained with the aid of the LoopTools package.« less

Déjà vu phenomenon-related EEG pattern. Case report.

PubMed

Vlasov, P N; Chervyakov, A V; Gnezditskii, V V

2013-01-01

Déjà vu (DV, from French déjà vu - "already seen") is an aberration of psychic activity associated with transitory erroneous perception of novel circumstances, objects, or people as already known. This study aimed to record the EEG pattern of déjà vu. The subjects participated in a survey concerning déjà vu characteristics and underwent ambulatory EEG monitoring (12-16 h). In patients with epilepsy, DV episodes began with polyspike activity in the right temporal lobe region and, in some cases, ended with slow-wave theta-delta activity over the right hemisphere. There were no epileptic discharges in healthy respondents during DV. Two types of déjà vu are suggested to exist: "pathological-epileptic" déjà vu, characteristic of patients with epilepsy and equivalent to an epileptic seizure, and "nonpathological-nonepileptic" déjà vu, which is characteristic of healthy people and psychological phenomenon.

The origin of RX J1856.5-3754 and RX J0720.4-3125 - updated using new parallax measurements

NASA Astrophysics Data System (ADS)

Tetzlaff, N.; Eisenbeiss, T.; Neuhäuser, R.; Hohle, M. M.

2011-10-01

RX J1856.5-3754 and RX J0720.4-3125 are the only young isolated radio-quiet neutron stars (NSs) for which trigonometric parallaxes were measured. Due to detection of their thermal emission in X-rays, they are important to study NS cooling and to probe theoretical cooling models. Hence, a precise determination of their age is essential. Recently, new parallax measurements of RX J1856.5-3754 and RX J0720.4-3125 were obtained. Considering that NSs may originate from binary systems that got disrupted due to an asymmetric supernova, we attempt to identify runaway stars which may have been former companions to the NS progenitors. Such an identification would strongly support a particular birth scenario with time and place. We trace back each NS, runaway star and the centres of possible birth associations (assuming that most NSs are ejected directly from their parent association) to find close encounters. The kinematic age is then given by the time since the encounter. We use Monte Carlo simulations to account for observational uncertainties and evaluate the outcome statistically. Using the most recent parallax measurement of 8.16 ± 0.80 mas for RX J1856.5-3754 by Walter et al., we find that it originated in the Upper Scorpius association 0.46 ± 0.05 Myr ago. This kinematic age is slightly larger than the value we reported earlier (0.3 Myr) using the old parallax value of 5.6 ± 0.6 mas by Kaplan. Our result is strongly supported by its current radial velocity which we predict to be 6+19- 20 km s-1. This implies an inclination angle to the line of sight of 88°± 6° consistent with estimates by van Kerkwijk & Kulkarni from the bow shock. No suitable runaway star was found to be a potential former companion of RX J1856.5-3754. Making use of a recent parallax measurement for RX J0720.4-3125 of 3.6 ± 1.6 mas by Eisenbeiss, we find that this NS was possibly born in Trumpler 10 0.85 ± 0.15 Myr ago. This kinematic age is somewhat larger than the one obtained using the old

Update on J /ψ regeneration in a hadron gas

NASA Astrophysics Data System (ADS)

Abreu, L. M.; Khemchandani, K. P.; Torres, A. Martínez; Navarra, F. S.; Nielsen, M.

2018-04-01

In heavy-ion collisions, after the quark-gluon plasma there is a hadronic gas phase. Using effective Lagrangians, we study the interactions of charmed mesons which lead to J /ψ production and absorption in this gas. We update and extend previous calculations introducing strange meson interactions and also including the interactions mediated by the recently measured exotic charmonium resonances Z (3900 ) and Z (4025 ) . These resonances open new reaction channels for the J /ψ , which could potentially lead to changes in its multiplicity. We compute the J /ψ production cross section in processes such as D(s) (*)+D¯(*)→J /ψ +(π ,ρ ,K ,K*) and also the J /ψ absorption cross section in the corresponding inverse processes. Using the obtained cross sections as input to solve the appropriate rate equation, we conclude that the interactions in the hadron gas phase lead to a 20-24% reduction of the J /ψ abundance. Within the uncertainties of the calculation, this reduction is the same at the Relativistic Heavy Ion Collider and the large Hadron Collider.

Déjà Vu Experiences in Healthy Czech Adults.

PubMed

Lacinová, Lenka; Neužilová Michalčáková, Radka; Širůček, Jan; Ježek, Stanislav; Chromec, Jakub; Masopustová, Zuzana; Urbánek, Tomáš; Brázdil, Milan

2016-12-01

The study examines the prevalence of déjà vu in healthy Czech adults and explores its relationships with a number of variables: age, sex, neuroticism, depression, the degree of irritability in the limbic system, perceived stress, and finally attachment avoidance and anxiety. The participants were 365 healthy adults ranging from 18 to 70 years recruited in the Czech Republic (mean age = 29.05; SD = 11.17) who filled out online questionnaires. Déjà vu experiences were reported by 324 (88.8%) of them. Persons who experienced déjà vu were younger than the persons who had not experienced it. We found that sex, levels of neuroticism, depression, perceived stress, and attachment did not serve as predictors of experiences of déjà vu phenomena. Finally, those who had reported déjà vu experiences reported more limbic system irritability symptoms. We discuss the possibility that déjà vu reports together with other studied variables mainly reflect the participants' willingness to report "extraordinal" experiences.

Extinction, seeing and sky transparency monitoring at the Observatorio Astrofísico de Javalambre for J-PAS and J-PLUS calibration and scheduling

NASA Astrophysics Data System (ADS)

Vázquez Ramió, H.; Díaz-Martín, M. C.; Varela, J.; Ederoclite, A.; Maícas, N. Lamadrid, J. L.; Abril, J.; Iglesias-Marzoa, R.; Rodríguez, S.; Tilve, V.; Cenarro, A. J.; Antón Bravo, J. L.; Bello Ferrer, R.; Cristóbal-Hornillos, D.; Guillén Civera, L.; Hernández-Fuertes, J.; Jiménez Mejías, D.; Lasso-Cabrera, N. M.; López Alegre, G.; López Sainz, A.; Luis-Simoes, R. M.; Marín-Franch, A.; Moles, M.; Rueda-Teruel, F.; Rueda-Teruel, S.; Suárez López, O.; Yanes-Díaz, A.

2015-05-01

The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS; see Benítez et al. 2014) and the Javalambre-Photometric Local Universe Survey (J-PLUS) will be conducted at the brand-new Observatorio Astrofísico de Javalambre (OAJ) in Teruel, Spain. J-PLUS is planned to start by the first half of 2015 while J-PAS first light is expected to happen along 2015. Besides the two main telescopes (with 2.5 m and 80 cm apertures), several smaller-sized facilities are present at the OAJ devoted to site characterization and supporting measurements to be used to calibrate the J-PAS and J-PLUS photometry and to feed up the OAJ's Sequencer with the integrated seeing and the sky transparency. These instruments are: i) an extinction monitor, an 11 " telescope estimating the atmospheric extinction to finally obtain the OAJ extinction curve, which is the initial step to J-PAS overall photometric calibration procedure; ii) an 8 " telescope implementing the Differential Image Motion Monitor (DIMM) technique to obtain the integrated seeing; and iii) an All-Sky Transmission MONitor (ASTMON), a roughly all-sky instrument providing the sky transparency as well as sky brightness and the atmospheric extinction too.

7. Historic American Buildings Survey Photocopy c. 1923 from J. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey Photocopy c. 1923 from J. J. Glessner The Story of a House FIRST FLOOR STAIRHALL: SOUTH - John J. Glessner House, 1800 South Prairie Avenue, Chicago, Cook County, IL

19 CFR 134.33 - J-List exceptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... with the provisions of section 304(a)(3)(J), Tariff Act of 1930, as amended (19 U.S.C. 1304(a)(3)(J... indicate the origin of its contents in accordance with the requirements of subpart C of this part. All articles are listed in Treasury Decisions 49690, 49835, and 49896. A reference different from the foregoing...

19 CFR 134.33 - J-List exceptions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... with the provisions of section 304(a)(3)(J), Tariff Act of 1930, as amended (19 U.S.C. 1304(a)(3)(J... indicate the origin of its contents in accordance with the requirements of subpart C of this part. All articles are listed in Treasury Decisions 49690, 49835, and 49896. A reference different from the foregoing...

8. Historic American Buildings Survey Photocopy c. 1923 from J. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey Photocopy c. 1923 from J. J. Glessner The Story of a House LIBRARY: WEST AND NORTH SIDES - John J. Glessner House, 1800 South Prairie Avenue, Chicago, Cook County, IL

Upgrade of absolute extreme ultraviolet diagnostic on J-TEXT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, X. L.; Cheng, Z. F., E-mail: chengfe@hust.edu.cn; Hou, S. Y.

The absolute extreme ultraviolet (AXUV) diagnostic system is used for radiation observation on J-TEXT tokamak [J. Zhang, G. Zhuang, Z. J. Wang, Y. H. Ding, X. Q. Zhang, and Y. J. Tang, Rev. Sci. Instrum. 81, 073509 (2010)]. The upgrade of the AXUV system is aimed to improve the spatial resolution and provide a three-dimensional image on J-TEXT. The new system consists of 12 AXUV arrays (4 AXUV16ELG arrays, 8 AXUV20ELG arrays). The spatial resolution in the cross-section is 21 mm for the AXUV16ELG arrays and 17 mm for the AXUV20ELG arrays. The pre-amplifier is also upgraded for a highermore » signal to noise ratio. By upgrading the AXUV imaging system, a more accurate observation on the radiation information is obtained.« less

11. Historic American Buildings Survey Photocopy c. 1923 from J. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic American Buildings Survey Photocopy c. 1923 from J. J. Glessner The Story of a House UPPER HALL - NORTH AND WEST SIDES - John J. Glessner House, 1800 South Prairie Avenue, Chicago, Cook County, IL

10. Historic American Buildings Survey Photocopy c. 1923 from J. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey Photocopy c. 1923 from J. J. Glessner The Story of a House DINING ROOM: WEST AND NORTH SIDES - John J. Glessner House, 1800 South Prairie Avenue, Chicago, Cook County, IL

Speaking Personally--With John Seely Brown

ERIC Educational Resources Information Center

American Journal of Distance Education, 2008

2008-01-01

This article presents an interview with John Seely Brown, a visiting scholar at the University of Southern California and a former chief scientist of Xerox Corporation and director of its Palo Alto Research Center (PARC)--a position he held for nearly two decades. While head of PARC, Brown expanded the role of corporate research to include such…

System Engineering Concept Demonstration, Interface Standards Studies. Volume 4

DTIC Science & Technology

1992-12-01

Xerox’s Palo Alto Research Center (PARC) 25 begat the Xerox Star; Steve Jobs visited PARC, saw the Star, went back to Apple, and begat the Mac. But...Author of Adobe Systems, PostScript Language Program Design, has left Adobe to join Steve Jobs ’ NeXT, Inc. Reid worked for Adobe Systems for four and a

Frequent topoisomerase IV mutations associated with fluoroquinolone resistance in Ureaplasma species.

PubMed

Song, Jingjuan; Qiao, Yingli; Kong, Yingying; Ruan, Zhi; Huang, Jun; Song, Tiejun; Zhang, Jun; Xie, Xinyou

2015-11-01

This study aimed to investigate the role of quinolone resistance-determining regions (QRDRs) of DNA gyrase (encoded by gyrA and gyrB) and topoisomerase IV (encoded by parC and parE) associated with fluoroquinolone resistance. A total of 114 Ureaplasma spp. strains, isolated from clinical female patients with symptomatic infection, were tested for species distribution and susceptibility to four fluoroquinolones. Moreover, we analysed the QRDRs and compared these with 14 ATCC reference strains of Ureaplasma spp. serovars to identify mutations that caused antimicrobial resistance. Our study indicated that moxifloxacin was the most effective fluoroquinolone against Ureaplasma spp. (MIC range: 0.125-32 μg ml⁻¹). However, extremely high MICs were estimated for ciprofloxacin (MIC range: 1-256 μg ml⁻¹) and ofloxacin (MIC range: 0.5-128 μg ml⁻¹), followed by levofloxacin (MIC range: 0.5-64 μg ml⁻¹). Seven amino acid substitutions were discovered in GyrB, ParC and ParE, but not in GyrA. Ser-83 → Leu/Trp (C248T/G) in ParC and Arg-448 → Lys (G1343A) in ParE, which were potentially responsible for fluoroquinolone resistance, were observed in 89 (77.2 %) and three (2.6 %) strains, respectively. Pro-462 → Ser (C1384T), Asn-481 → Ser (A1442G) and Ala-493 → Val (C1478T) in GyrB and Met-105 → Ile (G315T) in ParC seemed to be neutral polymorphisms, and were observed and occurred along with the amino acid change of Ser-83 → Leu (C248T) in ParC. Interestingly, two novel mutations of ParC and ParE were independently found in four strains. These observations suggest that amino acid mutation in topoisomerase IV appears to be the leading cause of fluoroquinolone resistance, especially the mutation of Ser-83 → Leu (C248T) in ParC. Moxifloxacin had the best activity against strains with Ser-83 → Leu mutation.

Confirming the gamma-ray blazar nature of the low energy counterpart QSO GB6 J1604+5714 of 2FGL J1604.6+5710 with WISE

NASA Astrophysics Data System (ADS)

Massaro, F.; D'Abrusco, R.; Paggi, A.

2012-06-01

Following the rapid optical variability detected in the QSO GB6 J1604+5714 (=BZQJ1604+5714) (ATEL #4184), associated to the gamma-ray source 2FGL J1604.6+5710 (=1FGL J1604.3+5710) in Nolan et al. (2012 ApJS, 199, 31), we searched in the Wide-field Infrared Survey Explorer (WISE; Wright et al. 2010 AJ, 140, 1868) catalog at the VLBI position of the QSO GB6 J1604+5714 (R.A.(J2000): 16h04m37.3546s, Dec.(J2000): +57d14m36.660s) reported in Beasley et al......

6. Historic American Buildings Survey Photocopy c. 1923 from J. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey Photocopy c. 1923 from J. J. Glessner The Story of a House FIRST FLOOR STAIRCASE: MAIN HALL NORTH END - John J. Glessner House, 1800 South Prairie Avenue, Chicago, Cook County, IL

Final science results: Spacelab J

NASA Technical Reports Server (NTRS)

Leslie, Fred (Editor)

1995-01-01

This report contains a brief summary of the mission science conducted aboard Spacelab J (SL-J), a joint venture between the National Aeronautics and Space Administration (NASA) and the National Space Development Agency (NASDA) of Japan. The scientific objectives of the mission were to conduct a variety of material and life science experiments utilizing the weightlessness and radiation environment of an orbiting Spacelab. All 43 experiments were activated; 24 in microgravity sciences (material processing, crystal growth, fluid physics, and acceleration measurement) and 19 in life sciences (physiology, developmental biology, radiation effects, separation processes, and enzyme crystal growth). In addition, more than a dozen experiments benefited from the extra day through either additional experiment runs or extended growth time.

XTE J1946+274 = GRO J1944+26: An Enigmatic Be/X-ray Binary

NASA Technical Reports Server (NTRS)

Wilson, Colleen A.; Finger, Mark H.; Coe, M. J.; Negueruela, Ignacio; Six, N. Frank (Technical Monitor)

2002-01-01

XTE J1946+274 = GRO J1944+26 is a 15.8-s Be/X-ray pulsar discovered simultaneously in 1998 September with the, Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory (CGRO) and the All-Sky Monitor (ASM) on the Rossi X-ray Timing Explorer (RXTE). Pulse timing analysis yielded an orbital period of 169.2 days, a moderate eccentricity of 0.33, and implied a mass function of 9.7 solar mass. We observed evidence for an accretion disk, a correlation between measured spin-up rate and flux, which was fitted to obtain a distance estimate of 9.2 +/- 1.0 kpc. XTE J1946+274 remained active from 1998 September - 2001 July, undergoing 13 outbursts that were not locked in orbital phase. Comparing RXTE PCA observations from the initial bright outburst in 1998 and the last pair of outburst in 2001, we found energy and intensity dependent pulse profile variations in both outbursts and hardening spectra with increasing intensity during the fainter 2001 outbursts. In 2001 July, optical H(alpha) observations indicate a density perturbation appeared in the Be disk as the X-ray outbursts ceased. We propose that the equatorial plane of the Be star is inclined with respect to the orbital plane in this system and that this inclination may produce the unusual outburst behavior of the system.

4. Historic American Buildings Survey Photocopy c. 1923 from J. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey Photocopy c. 1923 from J. J. Glessner The Story of a House DETAIL: GABLE AND CHIMNEY 18th STREET SIDE - John J. Glessner House, 1800 South Prairie Avenue, Chicago, Cook County, IL

Dalitz plot analyses of J / ψ → π + π - π 0 , J / ψ → K + K - π 0 , and J / ψ → K s 0 K ± π ∓ produced via e + e - annihilation with initial-state radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lees, J. P.; Poireau, V.; Tisserand, V.

We study the processes e + e - → γ ISR J / ψ , where J / ψ → π + π - π 0 , J / ψ → K + K - π 0 , and J / ψ → Kmore » $$0\\atop{S}$$ K ± π ∓ using a data sample of 519 fb - 1 recorded with the BABAR detector operating at the SLAC PEP-II asymmetric-energy e + e - collider at center-of-mass energies at and near the Υ ( n S ) ( n = 2 , 3 , 4 ) resonances.« less

Photolysis rates in correlated overlapping cloud fields: Cloud-J 7.3

DOE PAGES

Prather, M. J.

2015-05-27

A new approach for modeling photolysis rates ( J values) in atmospheres with fractional cloud cover has been developed and implemented as Cloud-J – a multi-scattering eight-stream radiative transfer model for solar radiation based on Fast-J. Using observed statistics for the vertical correlation of cloud layers, Cloud-J 7.3 provides a practical and accurate method for modeling atmospheric chemistry. The combination of the new maximum-correlated cloud groups with the integration over all cloud combinations represented by four quadrature atmospheres produces mean J values in an atmospheric column with root-mean-square errors of 4% or less compared with 10–20% errors using simpler approximations.more » Cloud-J is practical for chemistry-climate models, requiring only an average of 2.8 Fast-J calls per atmosphere, vs. hundreds of calls with the correlated cloud groups, or 1 call with the simplest cloud approximations. Another improvement in modeling J values, the treatment of volatile organic compounds with pressure-dependent cross sections is also incorporated into Cloud-J.« less

Déjà vu experiences are rarely associated with pathological dissociation.

PubMed

Adachi, Naoto; Akanuma, Nozomi; Akanu, Nozomi; Adachi, Takuya; Takekawa, Yoshikazu; Adachi, Yasushi; Ito, Masumi; Ikeda, Hiroshi

2008-05-01

We investigated the relation between déjà vu and dissociative experiences in nonclinical subjects. In 227 adult volunteers, déjà vu and dissociative experiences were evaluated by means of the inventory of déjà vu experiences assessment and dissociative experiences scale (DES). Déjà vu experiences occurred in 162 (71.4%) individuals. In univariate correlation analysis, the frequency of déjà vu experiences, as well as 5 other inventory of déjà vu experiences assessment symptoms and age at the time of evaluation, correlated significantly with the DES score. After exclusion of intercorrelative effects using multiple regression analysis, déjà vu experiences did not remain in the model. The DES score was best correlated with a model that included age, jamais vu, depersonalization, and precognitive dreams. Two indices for pathological dissociation (DES-taxon and DES > or = 30) were not associated with déjà vu experiences. Our findings suggest that déjà vu experiences are unlikely to be core pathological dissociative experiences.

Redox-active tyrosine residue in the microcin J25 molecule

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chalon, Miriam C.; Wilke, Natalia; Pedersen, Jens

2011-03-18

Research highlights: {yields} Cyclic voltammetry measurements showed irreversible oxidation of MccJ25 and MccJ25 (Y9F). {yields} Infrared spectroscopy studies showed that only Tyr9 could be deprotonated upon chemical oxidation. {yields} Formation of a long-lived tyrosyl radical in the native MccJ25 oxidized by H{sub 2}O{sub 2} was demonstrated. {yields} Tyr9 but not Tyr20 can be easily oxidized and form a tyrosyl radical. -- Abstract: Microcin J25 (MccJ25) is a 21 amino acid lasso-peptide antibiotic produced by Escherichia coli and composed of an 8-residues ring and a terminal 'tail' passing through the ring. We have previously reported two cellular targets for this antibiotic,more » bacterial RNA polymerase and the membrane respiratory chain, and shown that Tyr9 is essential for the effect on the membrane respiratory chain which leads to superoxide overproduction. In the present paper we investigated the redox behavior of MccJ25 and the mutant MccJ25 (Y9F). Cyclic voltammetry measurements showed irreversible oxidation of both Tyr9 and Tyr20 in MccJ25, but infrared spectroscopy studies demonstrated that only Tyr9 could be deprotonated upon chemical oxidation in solution. Formation of a long-lived tyrosyl radical in the native MccJ25 oxidized by H{sub 2}O{sub 2} was demonstrated by Electron Paramagnetic Resonance Spectroscopy; this radical was not detected when the reaction was carried out with the MccJ25 (Y9F) mutant. These results show that the essential Tyr9, but not Tyr20, can be easily oxidized and form a tyrosyl radical.« less

Persistent psychogenic déjà vu: a case report.

PubMed

Wells, Christine E; Moulin, Chris J A; Ethridge, Paige; Illman, Nathan A; Davies, Emma; Zeman, Adam

2014-12-08

Déjà vu is typically a transient mental state in which a novel experience feels highly familiar. Although extensively studied in relation to temporal lobe epilepsy as part of simple partial seizures, déjà vu has been less studied in other clinical populations. A recent review of temporal lobe epilepsy suggested a possible link between clinical levels of anxiety and debilitating déjà vu, indicating further research is required. Here, for the first time in the literature, we present a case study of a young man with anxiety and depersonalisation who reported experiencing persistent and debilitating déjà vu. This report therefore adds to the limited literature on the relationship between anxiety and déjà vu. A 23-year-old White British man presented with a form of persistent déjà vu in 2010, approximately 3 years since symptom onset. He reported a history of anxiety and experiencing feelings of depersonalisation. Neurological assessment (electroencephalogram and magnetic resonance imaging) did not indicate any abnormalities. We assessed his recognition memory with a task used in patients with dementia who report similar experiences but lack awareness of their falseness. Our case's memory performance was more conservative than controls but did not indicate a memory deficit. Unlike other patients with chronic déjà vu (for example, in dementia), he is fully aware of the false nature of his déjà vu and this presumably leads to his intact recognition memory performance. We suggest that his persistent déjà vu is psychogenic and conclude that déjà vu should be further studied in psychiatric disorders.

Elastic and inelastic photoproduction of J/ ψ mesons at HERA

NASA Astrophysics Data System (ADS)

Aid, S.; Andreev, V.; Andrieu, B.; Appuhn, R.-D.; Arpagaus, M.; Babaev, A.; Bähr, J.; Bán, J.; Ban, Y.; Baranov, P.; Barrelet, E.; Barschke, R.; Bartel, W.; Barth, M.; Bassler, U.; Beck, H. P.; Behrend, H.-J.; Belousov, A.; Berger, Ch.; Bernardi, G.; Bernet, R.; Bertrand-Coremans, G.; Besançon, M.; Beyer, R.; Biddulph, P.; Bispham, P.; Bizot, J. C.; Blobel, V.; Borras, K.; Botterweck, F.; Boudry, V.; Braemer, A.; Braunschweig, W.; Brisson, V.; Bruncko, D.; Brune, C.; Buchholz, R.; Büngener, L.; Bürger, J.; Büsser, F. W.; Buniatian, A.; Burke, S.; Burton, M. J.; Buschhorn, G.; Campbell, A. J.; Carli, T.; Charles, F.; Charlet, M.; Clarke, D.; Clegg, A. B.; Clerbaux, B.; Cocks, S.; Contreras, J. G.; Cormack, C.; Coughlan, J. A.; Courau, A.; Cousinou, M.-C.; Cozzika, G.; Criegee, L.; Cussans, D. G.; Cvach, J.; Dagoret, S.; Dainton, J. B.; Dau, W. D.; Daum, K.; David, M.; Davis, C. L.; Delcourt, B.; De Roeck, A.; De Wolf, E. A.; Dirkmann, M.; Dixon, P.; Di Nezza, P.; Dlugosz, W.; Dollfus, C.; Dowell, J. D.; Dreis, H. B.; Droutskoi, A.; Düllmann, D.; Dünger, O.; Duhm, H.; Ebert, J.; Ebert, T. R.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellison, R. J.; Elsen, E.; Erdmann, M.; Erdmann, W.; Evrard, E.; Fahr, A. B.; Favart, L.; Fedotov, A.; Feeken, D.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrarotto, F.; Flamm, K.; Fleischer, M.; Flieser, M.; Flügge, G.; Fomenko, A.; Fominykh, B.; Formánek, J.; Foster, J. M.; Franke, G.; Fretwurst, E.; Gabathuler, E.; Gabathuler, K.; Gaede, F.; Garvey, J.; Gayler, J.; Gebauer, M.; Gellrich, A.; Genzel, H.; Gerhards, R.; Glazov, A.; Goerlach, U.; Goerlich, L.; Gogitidze, N.; Goldberg, M.; Goldner, D.; Golec-Biernat, K.; Gonzalez-Pineiro, B.; Gorelov, I.; Grab, C.; Grässler, H.; Grässler, R.; Greenshaw, T.; Griffiths, R.; Grindhammer, G.; Gruber, A.; Gruber, C.; Haack, J.; Haidt, D.; Hajduk, L.; Hampel, M.; Haynes, W. J.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Herynek, I.; Hess, M. F.; Hildesheim, W.; Hiller, K. H.; Hilton, C. D.; Hladký, J.; Hoeger, K. C.; Höppner, M.; Hoffmann, D.; Holtom, T.; Horisberger, R.; Hudgson, V. L.; Hütte, M.; Hufnagel, H.; Ibbotson, M.; Itterbeck, H.; Jacholkowska, A.; Jacobsson, C.; Jaffre, M.; Janoth, J.; Jansen, T.; Jöhnson, L.; Johannsen, K.; Johnson, D. P.; Johnson, L.; Jung, H.; Kalmus, P. I. P.; Kander, M.; Kant, D.; Kaschowitz, R.; Kathage, U.; Katzy, J.; Kaufmann, H. H.; Kaufmann, O.; Kazarian, S.; Kenyon, I. R.; Kermiche, S.; Keuker, C.; Kiesling, C.; Klein, M.; Kleinwort, C.; Knies, G.; Köhler, T.; Köhne, J. H.; Kolanoski, H.; Kole, F.; Kolya, S. D.; Korbel, V.; Korn, M.; Kostka, P.; Kotelnikov, S. K.; Krämerkämper, T.; Krasny, M. W.; Krehbiel, H.; Krücker, D.; Krüger, U.; Krüner-Marquis, U.; Küster, H.; Kuhlen, M.; Kurča, T.; Kurzhöfer, J.; Lacour, D.; Laforge, B.; Lander, R.; Landon, M. P. J.; Lange, W.; Langenegger, U.; Laporte, J.-F.; Lebedev, A.; Lehner, F.; Leverenz, C.; Levonian, S.; Ley, Ch.; Lindström, G.; Lindstroem, M.; Link, J.; Linsel, F.; Lipinski, J.; List, B.; Lobo, G.; Lohmander, H.; Lomas, J. W.; Lopez, G. C.; Lubimov, V.; Lüke, D.; Magnussen, N.; Malinovski, E.; Mani, S.; Maraček, R.; Marage, P.; Marks, J.; Marshall, R.; Martens, J.; Martin, G.; Martin, R.; Martyn, H.-U.; Martyniak, J.; Mavroidis, T.; Maxfield, S. J.; McMahon, S. J.; Mehta, A.; Meier, K.; Merz, T.; Meyer, A.; Meyer, A.; Meyer, H.; Meyer, J.; Meyer, P.-O.; Migliori, A.; Mikocki, S.; Milstead, D.; Moeck, J.; Moreau, F.; Morris, J. V.; Mroczko, E.; Müller, D.; Müller, G.; Müller, K.; Murín, P.; Nagovizin, V.; Nahnhauer, R.; Naroska, B.; Naumann, Th.; Newman, P. R.; Newton, D.; Neyret, D.; Nguyen, H. K.; Nicholls, T. C.; Niebergall, F.; Niebuhr, C.; Niedzballa, Ch.; Niggli, H.; Nisius, R.; Nowak, G.; Noyes, G. W.; Nyberg-Werther, M.; Oakden, M.; Oberlack, H.; Obrock, U.; Olsson, J. E.; Ozerov, D.; Palmen, P.; Panaro, E.; Panitch, A.; Pascaud, C.; Patel, G. D.; Pawletta, H.; Peppel, E.; Perez, E.; Phillips, J. P.; Pieuchot, A.; Pitzl, D.; Pope, G.; Prell, S.; Prosi, R.; Rabbertz, K.; Rädel, G.; Raupach, F.; Reimer, P.; Reinshagen, S.; Rick, H.; Riech, V.; Riedlberger, J.; Riepenhausen, F.; Riess, S.; Rizvi, E.; Robertson, S. M.; Robmann, P.; Roloff, H. E.; Roosen, R.; Rosenbauer, K.; Rostovtsev, A.; Rouse, F.; Royon, C.; Rüter, K.; Rusakov, S.; Rybicki, K.; Sahlmann, N.; Sankey, D. P. C.; Schacht, P.; Schiek, S.; Schleif, S.; Schleper, P.; von Schlippe, W.; Schmidt, D.; Schmidt, G.; Schöning, A.; Schröder, V.; Schuhmann, E.; Schwab, B.; Sefkow, F.; Seidel, M.; Sell, R.; Semenov, A.; Shekelyan, V.; Sheviakov, I.; Shtarkov, L. N.; Siegmon, G.; Siewert, U.; Sirois, Y.; Skillicorn, I. O.; Smirnov, P.; Smith, J. R.; Solochenko, V.; Soloviev, Y.; Specka, A.; Spiekermann, J.; Spielman, S.; Spitzer, H.; Squinabol, F.; Starosta, R.; Steenbock, M.; Steffen, P.; Steinberg, R.; Steiner, H.; Stella, B.; Stellberger, A.; Stier, J.; Stiewe, J.; Stöβlein, U.; Stolze, K.; Straumann, U.; Struczinski, W.; Sutton, J. P.; Tapprogge, S.; Taševský, M.; Tchernyshov, V.; Tchetchelnitski, S.; Theissen, J.; Thiebaux, C.; Thompson, G.; Truöl, P.; Turnau, J.; Tutas, J.; Uelkes, P.; Usik, A.; Valkár, S.; Valkárová, A.; Vallée, C.; Vandenplas, D.; Van Esch, P.; Van Mechelen, P.; Vazdik, Y.; Verrecchia, P.; Villet, G.; Wacker, K.; Wagener, A.; Wagener, M.; Walther, A.; Waugh, B.; Weber, G.; Weber, M.; Wegener, D.; Wegner, A.; Wengler, T.; Werner, M.; West, L. R.; Wilksen, T.; Willard, S.; Winde, M.; Winter, G.-G.; Wittek, C.; Wünsch, E.; Žáček, J.; Zarbock, D.; Zhang, Z.; Zhokin, A.; Zimmer, M.; Zomer, F.; Zsembery, J.; Zuber, K.; zurNedden, M.; H1 Collaboration

1996-02-01

Results on J/ ψ production in ep interactions in the H1 experiment at HERA are presented. The J/ ψ mesons are produced by almost real photons ( Q2 ≈ 0) and detected via their leptonic decays. The data have been taken in 1994 and correspond to an integrated luminosity of 2.7 pb -1. The γp cross section for elastic J/ ψ production is observed to increase strongly with the center of mass energy. The cross section for diffractive J/ ψ production with proton dissociation is found to be of similar magnitude as the elastic cross section. Distributions of transverse momentum and decay angle are studied and found to be in accord with a diffractive production mechanism. For inelastic J/ ψ production the total γp cross section, the distribution of transverse momenta, and the elasticity of the J/ ψ are compared to NLO QCD calculations in a colour singlet model and agreement is found. Diffractive ψ' production has been observed and a first estimate of the ratio to J/ ψ production in the HERA energy regime is given.

Déjà vu phenomenon-related EEG pattern. Case report☆

PubMed Central

Vlasov, P.N.; Chervyakov, A.V.; Gnezditskii, V.V.

2013-01-01

Background Déjà vu (DV, from French déjà vu — “already seen”) is an aberration of psychic activity associated with transitory erroneous perception of novel circumstances, objects, or people as already known. Objective This study aimed to record the EEG pattern of déjà vu. Methods The subjects participated in a survey concerning déjà vu characteristics and underwent ambulatory EEG monitoring (12–16 h). Results In patients with epilepsy, DV episodes began with polyspike activity in the right temporal lobe region and, in some cases, ended with slow-wave theta–delta activity over the right hemisphere. There were no epileptic discharges in healthy respondents during DV. Conclusion Two types of déjà vu are suggested to exist: “pathological-epileptic” déjà vu, characteristic of patients with epilepsy and equivalent to an epileptic seizure, and “nonpathological-nonepileptic” déjà vu, which is characteristic of healthy people and psychological phenomenon. PMID:25667847

Recurring déjà vu associated with 5-hydroxytryptophan.

PubMed

Kalra, Seema; Chancellor, Andrew; Zeman, Adam

2007-10-01

Déjà vu occurs both in normal experience and as a neuropsychiatric symptom. Its pathogenesis is partially understood. We describe an iatrogenic case with implications for the neuropharmacological basis of déjà vu. A 42-year-old woman received 5-hydroxytryptophan, in combination with carbidopa, as treatment for palatal tremor, on two occasions, separated by 1 week. On each occasion, she experienced intense, protracted déjà vu, lasting for several hours. We discuss her case in relation to the neuroanatomical and neuropharmacological basis of déjà vu. The serotonergic system is involved in the genesis of déjà vu.

Spectralon solar diffuser BRDF variation for NPP, JPSS J1 and J2

NASA Astrophysics Data System (ADS)

Murgai, Vijay; Johnson, Lindsay; Klein, Staci

2017-09-01

The Visible/Infrared Imaging Radiometer Suite (VIIRS) is a key sensor on the Suomi National Polar-orbiting Partnership (NPP) satellite as well as the upcoming Joint Polar Satellite System (JPSS). VIIRS collects Earth radiometric and imagery data in 22 spectral bands from 0.4 to 12.5 μm. Radiometric calibration of the reflective bands in the 0.4 to 2.5 μm wavelength range is performed by measuring the sunlight reflectance from Spectralon®. Reflected sun light is directly proportional to the Bidirectional Reflectance Distribution Function (BRDF) of the Spectralon. This paper presents the BRDF measurements of the Spectralon for JPSS J2 in the 0.4 - 1.63 μm wavelength using PASCAL (Polarization And Scatter Characterization Analysis of Lambertian materials) with an uncertainty better than 1.2%. PASCAL makes absolute measurements of the BRDF in an analogous fashion to the National Institute of Standards and Technology (NIST) Spectral Tri-function Automated Reflectance Reflectometer (STARR) facility. Unique additional features of this instrument include the ability to vary the sample elevation and roll / clock the sample about its normal, allowing measurement of BRDF in the as used geometry. Comparison of BRDF in the as used configuration for NPP, J1, and J2 shows variation of up to 3%. The sign of the change from panel to panel depends on the angle of incidence and view angle. The results demonstrate lot to lot variability in Spectralon and emphasize the necessity of characterizing each panel. A pattern in the BRDF variation is also presented.

Evaluation of bacterial kill when modelling the bronchopulmonary pharmacokinetic profile of moxifloxacin and levofloxacin against parC-containing isolates of Streptococcus pneumoniae.

PubMed

Deryke, C Andrew; Du, Xiaoli; Nicolau, David P

2006-09-01

The increasingly recognized prevalence of first-step parC mutants in Streptococcus pneumoniae and the development of de novo resistance while on fluoroquinolone therapy are of concern. Previous work by our group demonstrated the ability of moxifloxacin, but not levofloxacin, to eradicate parC mutants. The objective of this experiment was to determine whether these fluoroquinolone antibiotics provided equivalent bacterial kill when similar AUC/MICs were examined. An in vitro pharmacodynamic model was used to simulate the epithelial lining fluid (ELF) concentrations following oral administration of levofloxacin 500 mg once daily and moxifloxacin 400 mg once daily in older adults. In addition, a range of AUC/MICs were also modelled, including levofloxacin 750 mg once daily. Five different S. pneumoniae containing first-step parC mutations and one isolate without mutations were tested for 48 h and time-kill curves were constructed. Samples at 0, 24 and 48 h were collected for phenotypic and genotypic profiling. HPLC was used to verify that target exposures were achieved. The isolate without a parC mutation displayed a 4 log reduction in cfu after treatment with levofloxacin 500 mg and did not select for resistance. In all five isolates containing first-step parC mutations, resistance emerged within 48 h with a > or =16-fold increase in MIC and the acquisition of a gyrA mutant. Increasing the exposure of levofloxacin to approximately 750 mg dose still led to > or =16-fold increase in MIC at 48 h in two of the four isolates containing parC mutations. On the other hand, moxifloxacin 400 mg sustained bacterial killing against the two isolates tested without the selection of resistant mutants. It appears that the critical AUC/MIC necessary to prevent the acquisition of resistance for levofloxacin is 200 and approximately 400 for moxifloxacin. Due to suboptimal exposures, once-daily oral regimens of levofloxacin at both 500 and 750 mg inconsistently led to bactericidal

J-2X Fuel Turbopump Point of Departure: The Performance of the J-2s Fuel Turbopump Inducer

NASA Technical Reports Server (NTRS)

Sargent, S. R.; Becht, D. G.; Mulder, A. D.

2008-01-01

To aid the J-2X program design effort with detailed performance and environment information, the J-2S fuel turbopump (FTP) inducer has undergone a thorough test series in both water and hydrogen. The test series utilizes both inducer only and a complete pump configuration to assess the inducer interaction to the overall turbopump system. The test goals include verification of suction performance against heritage J-2S data, head production, effects of thermodynamic suppression head (TSH), and evaluation of the inducer dynamic pressure caused by cavitation instabilities. Test facilities at both Pratt & Whitney Rocketdyne (PWR) and NASA s Stennis Space Center (SSC) are employed for the testing. The inducer only water test effort conducted at PWR established performance curves for suction performance, head production, and efficiency over a wide operating range. Because the heritage J-2S suction performance data set is in hydrogen, it is desired to obtain current suction performance data in hydrogen as well, thus avoiding the reliance on a theoretical TSH correlation for direct comparison. This data then provides an empirically based TSH correlation allowing for the comparison of water test suction data to system suction requirements. The FTP testing performed at SSC provides these suction performance relationships as well as inlet duct dynamic pressures during liquid hydrogen operation. The test effort successfully confirms the heritage J-2S suction performance and establishes the amount of TSH between water and hydrogen operation at the design flow coefficient. Correlating data is also obtained for cavitating instability frequency content, illustrating the validity of using the wide flow range water test data to predict hydrogen performance.

WISEP J061135.13-041024.0 AB: A J-band Flux Reversal Binary at the L/T Transition

NASA Astrophysics Data System (ADS)

Gelino, Christopher R.; Smart, R. L.; Marocco, Federico; Kirkpatrick, J. Davy; Cushing, Michael C.; Mace, Gregory; Mendez, Rene A.; Tinney, C. G.; Jones, Hugh R. A.

2014-07-01

We present Keck II laser guide star adaptive optics observations of the brown dwarf WISEP J061135.13-041024.0 showing it is a binary with a component separation of 0.''4. This system is one of the six known resolved binaries in which the magnitude differences between the components show a reversal in sign between the Y/J band and the H/K bands. Deconvolution of the composite spectrum results in a best-fit binary solution with L9 and T1.5 components. We also present a preliminary parallax placing the system at a distance of 21.2 ± 1.3 pc. Using the distance and resolved magnitudes we are able to place WISEP J061135.13-041024.0 AB on a color-absolute magnitude diagram, showing that this system contributes to the well-known "J-band bump" and the components' properties appear similar to other late-type L and early-type T dwarfs. Fitting our data to a set of cloudy atmosphere models suggests the system has an age >1 Gyr with WISE 0611-0410 A having an effective temperature (T eff) of 1275-1325 K and mass of 64-65 M Jup, and WISE 0611-0410 B having T eff = 1075-1115 K and mass 40-65 M Jup.

Unveiling the origin of HESS J1809-193

NASA Astrophysics Data System (ADS)

Castelletti, G.; Giacani, E.; Petriella, A.

2016-03-01

Aims: The main goal of this paper is to provide new insights on the origin of the observable flux of γ rays from HESS J1809-193 using new high-quality observations in the radio domain. Methods: We used the Expanded Very Large Array (now known as the Karl G. Jansky Very large Array, JVLA) to produce a deep full-synthesis imaging at 1.4 GHz of the vicinity of PSR J1809-1917. These data were used in conjunction with 12CO observations from the James Clerk Maxwell Telescope in the transition line J = 3-2 and atomic hydrogen data from the Southern Galactic Plane Survey to investigate the properties of the interstellar medium in the direction of the source HESS J1809-193. Results: The new radio continuum image, obtained with a synthesized beam of 8'' × 4'' and a sensitivity of 0.17 mJy beam-1, reveals with unprecedented detail all the intensity structures in the field. No radio counterpart to the observed X-ray emission supposed to be a pulsar wind nebula powered by PSR J1809-1917 is seen in the new JVLA image. We discovered a system of molecular clouds on the edge of the supernova remnant (SNR) G11.0-0.0 shock front, which is positionally coincident with the brightest part of the TeV source HESS J1809-193. We determine, on the basis of kinematic and morphological evidences, a physical link of the SNR with the clouds for which we estimated a total (molecular plus atomic) mass of ~3 × 103M⊙ and a total proton density in the range 2-3 × 103 cm-3. Conclusions: We propose as the most likely origin of the very high-energy γ-ray radiation from HESS J1809-193 a hadronic mechanism through collisions of ions accelerated at the SNR G11.0-0.0 shock with the molecular matter in the vicinity of the remnant. The new JVLA image (in FITS format) is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/587/A71

Rhinal-hippocampal interactions during déjà vu.

PubMed

Bartolomei, Fabrice; Barbeau, Emmanuel J; Nguyen, Trung; McGonigal, Aileen; Régis, Jean; Chauvel, Patrick; Wendling, Fabrice

2012-03-01

The phenomenon of 'déjà vu' is caused by acute disturbance of mnemonic systems of the medial temporal lobe (MTL). In epileptic patients investigated with intracerebral electrodes, déjà vu can be more readily induced by stimulation of the rhinal cortices (RCs) than the hippocampus (H). Whether déjà vu results from acute dysfunction of the familiarity system alone (sustained by RC) or from more extensive involvement of the MTL region (including H) is debatable. We analysed the synchronisation of intracerebral electroencephalography (EEG) signals recorded from RC, H and amygdala (A) in epileptic patients in whom déjà vu was induced by electrical stimulation. EEG signal correlations (between signals from RC, A and H) were evaluated using a nonlinear regression. In comparison with RC stimulations that did not lead to déjà vu (DV-), stimulations triggering déjà vu (DV+) were associated with increased broadband EEG correlation (p=0.01). Changes in correlations were significantly different in the theta band for RC-A (p=0.007) and RC-H (p=0.01) and in the beta band for RC-H (p=0.001) interactions. Déjà vu is associated with increased EEG signal correlation between MTL structures. Results are in favour of a mechanism involving transient co-operation between various MTL structures, not limited to RC alone. Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Measurement of the Ratio of Branching Fractions B (Bc+→J /ψ τ+ντ)/B (Bc+→J /ψ μ+νμ)

NASA Astrophysics Data System (ADS)

Aaij, R.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Alfonso Albero, A.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Archilli, F.; d'Argent, P.; Arnau Romeu, J.; Artamonov, A.; Artuso, M.; Aslanides, E.; Atzeni, M.; Auriemma, G.; Baalouch, M.; Babuschkin, I.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baker, S.; Balagura, V.; Baldini, W.; Baranov, A.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Baryshnikov, F.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Beiter, A.; Bel, L. J.; Beliy, N.; Bellee, V.; Belloli, N.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Beranek, S.; Berezhnoy, A.; Bernet, R.; Berninghoff, D.; Bertholet, E.; Bertolin, A.; Betancourt, C.; Betti, F.; Bettler, M.-O.; van Beuzekom, M.; Bezshyiko, Ia.; Bifani, S.; Billoir, P.; Birnkraut, A.; Bizzeti, A.; Bjørn, M.; Blake, T.; Blanc, F.; Blusk, S.; Bocci, V.; Boettcher, T.; Bondar, A.; Bondar, N.; Bordyuzhin, I.; Borghi, S.; Borisyak, M.; Borsato, M.; Bossu, F.; Boubdir, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Britton, T.; Brodzicka, J.; Brundu, D.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, J.; Byczynski, W.; Cadeddu, S.; Cai, H.; Calabrese, R.; Calladine, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D. H.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Cattaneo, M.; Cavallero, G.; Cenci, R.; Chamont, D.; Chapman, M. G.; Charles, M.; Charpentier, Ph.; Chatzikonstantinidis, G.; Chefdeville, M.; Chen, S.; Cheung, S. F.; Chitic, S.-G.; Chobanova, V.; Chrzaszcz, M.; Chubykin, A.; Ciambrone, P.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collins, P.; Colombo, T.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombs, G.; Coquereau, S.; Corti, G.; Corvo, M.; Costa Sobral, C. M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Currie, R.; D'Ambrosio, C.; Da Cunha Marinho, F.; Dall'Occo, E.; Dalseno, J.; Davis, A.; De Aguiar Francisco, O.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Serio, M.; De Simone, P.; Dean, C. T.; Decamp, D.; Del Buono, L.; Dembinski, H.-P.; Demmer, M.; Dendek, A.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Nezza, P.; Dijkstra, H.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Douglas, L.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Durante, P.; Dzhelyadin, R.; Dziewiecki, M.; Dziurda, A.; Dzyuba, A.; Easo, S.; Ebert, M.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Farley, N.; Farry, S.; Fazzini, D.; Federici, L.; Ferguson, D.; Fernandez, G.; Fernandez Declara, P.; Fernandez Prieto, A.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fini, R. A.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fohl, K.; Fontana, M.; Fontanelli, F.; Forshaw, D. C.; Forty, R.; Franco Lima, V.; Frank, M.; Frei, C.; Fu, J.; Funk, W.; Furfaro, E.; Färber, C.; Gabriel, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garcia Martin, L. M.; García Pardiñas, J.; Garra Tico, J.; Garrido, L.; Garsed, P. J.; Gascon, D.; Gaspar, C.; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianı, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gizdov, K.; Gligorov, V. V.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gorelov, I. V.; Gotti, C.; Govorkova, E.; Grabowski, J. P.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greim, R.; Griffith, P.; Grillo, L.; Gruber, L.; Gruberg Cazon, B. R.; Grünberg, O.; Gushchin, E.; Guz, Yu.; Gys, T.; Göbel, C.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hamilton, B.; Han, X.; Hancock, T. H.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Hasse, C.; Hatch, M.; He, J.; Hecker, M.; Heinicke, K.; Heister, A.; Hennessy, K.; Henrard, P.; Henry, L.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hombach, C.; Hopchev, P. H.; Hu, W.; Huard, Z. C.; Hulsbergen, W.; Humair, T.; Hushchyn, M.; Hutchcroft, D.; Ibis, P.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jalocha, J.; Jans, E.; Jawahery, A.; Jiang, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Karacson, M.; Kariuki, J. M.; Karodia, S.; Kazeev, N.; Kecke, M.; Keizer, F.; Kelsey, M.; Kenzie, M.; Ketel, T.; Khairullin, E.; Khanji, B.; Khurewathanakul, C.; Kirn, T.; Klaver, S.; Klimaszewski, K.; Klimkovich, T.; Koliiev, S.; Kolpin, M.; Kopecna, R.; Koppenburg, P.; Kosmyntseva, A.; Kotriakhova, S.; Kozeiha, M.; Kravchuk, L.; Kreps, M.; Kress, F.; Krokovny, P.; Kruse, F.; Krzemien, W.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; Leflat, A.; Lefrançois, J.; Lefèvre, R.; Lemaitre, F.; Lemos Cid, E.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, P.-R.; Li, T.; Li, Y.; Li, Z.; Likhomanenko, T.; Lindner, R.; Lionetto, F.; Lisovskyi, V.; Liu, X.; Loh, D.; Loi, A.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Lusiani, A.; Lyu, X.; Machefert, F.; Maciuc, F.; Macko, V.; Mackowiak, P.; Maddrell-Mander, S.; Maev, O.; Maguire, K.; Maisuzenko, D.; Majewski, M. W.; Malde, S.; Malecki, B.; Malinin, A.; Maltsev, T.; Manca, G.; Mancinelli, G.; Marangotto, D.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marinangeli, M.; Marino, P.; Marks, J.; Martellotti, G.; Martin, M.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Massacrier, L. M.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Mauri, A.; Maurice, E.; Maurin, B.; Mazurov, A.; McCann, M.; McNab, A.; McNulty, R.; Mead, J. V.; Meadows, B.; Meaux, C.; Meier, F.; Meinert, N.; Melnychuk, D.; Merk, M.; Merli, A.; Michielin, E.; Milanes, D. A.; Millard, E.; Minard, M.-N.; Minzoni, L.; Mitzel, D. S.; Mogini, A.; Molina Rodriguez, J.; Mombächer, T.; Monroy, I. A.; Monteil, S.; Morandin, M.; Morello, M. J.; Morgunova, O.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Mulder, M.; Müller, D.; Müller, J.; Müller, K.; Müller, V.; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, T. D.; Nguyen-Mau, C.; Nieswand, S.; Niet, R.; Nikitin, N.; Nikodem, T.; Nogay, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Oldeman, R.; Onderwater, C. J. G.; Ossowska, A.; Otalora Goicochea, J. M.; Owen, P.; Oyanguren, A.; Pais, P. R.; Palano, A.; Palutan, M.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parker, W.; Parkes, C.; Passaleva, G.; Pastore, A.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petrov, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pikies, M.; Pinci, D.; Pisani, F.; Pistone, A.; Piucci, A.; Placinta, V.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poli Lener, M.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Pomery, G. J.; Ponce, S.; Popov, A.; Popov, D.; Poslavskii, S.; Potterat, C.; Price, E.; Prisciandaro, J.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Pullen, H.; Punzi, G.; Qian, W.; Quagliani, R.; Quintana, B.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Ramos Pernas, M.; Rangel, M. S.; Raniuk, I.; Ratnikov, F.; Raven, G.; Ravonel Salzgeber, M.; Reboud, M.; Redi, F.; Reichert, S.; dos Reis, A. C.; Remon Alepuz, C.; Renaudin, V.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Robert, A.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rogozhnikov, A.; Roiser, S.; Rollings, A.; Romanovskiy, V.; Romero Vidal, A.; Ronayne, J. W.; Rotondo, M.; Rudolph, M. S.; Ruf, T.; Ruiz Valls, P.; Ruiz Vidal, J.; Saborido Silva, J. J.; Sadykhov, E.; Sagidova, N.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarpis, G.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schael, S.; Schellenberg, M.; Schiller, M.; Schindler, H.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schreiner, H. F.; Schubiger, M.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepulveda, E. S.; Sergi, A.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Siddi, B. G.; Silva Coutinho, R.; Silva de Oliveira, L.; Simi, G.; Simone, S.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, E.; Smith, I. T.; Smith, J.; Smith, M.; Soares Lavra, l.; Sokoloff, M. D.; Soler, F. J. P.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Stefko, P.; Stefkova, S.; Steinkamp, O.; Stemmle, S.; Stenyakin, O.; Stepanova, M.; Stevens, H.; Stone, S.; Storaci, B.; Stracka, S.; Stramaglia, M. E.; Straticiuc, M.; Straumann, U.; Sun, J.; Sun, L.; Sutcliffe, W.; Swientek, K.; Syropoulos, V.; Szumlak, T.; Szymanski, M.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; Thomas, E.; van Tilburg, J.; Tilley, M. J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Toriello, F.; Tourinho Jadallah Aoude, R.; Tournefier, E.; Traill, M.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tully, A.; Tuning, N.; Ukleja, A.; Usachov, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagner, A.; Vagnoni, V.; Valassi, A.; Valat, S.; Valenti, G.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vecchi, S.; van Veghel, M.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Venkateswaran, A.; Verlage, T. A.; Vernet, M.; Vesterinen, M.; Viana Barbosa, J. V.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Viemann, H.; Vilasis-Cardona, X.; Vitti, M.; Volkov, V.; Vollhardt, A.; Voneki, B.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Vázquez Sierra, C.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wang, J.; Ward, D. R.; Wark, H. M.; Watson, N. K.; Websdale, D.; Weiden, A.; Weisser, C.; Whitehead, M.; Wicht, J.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M. P.; Williams, M.; Williams, T.; Wilson, F. F.; Wimberley, J.; Winn, M.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wraight, K.; Wyllie, K.; Xie, Y.; Xu, M.; Xu, Z.; Yang, Z.; Yang, Z.; Yao, Y.; Yin, H.; Yu, J.; Yuan, X.; Yushchenko, O.; Zarebski, K. A.; Zavertyaev, M.; Zhang, L.; Zhang, Y.; Zhelezov, A.; Zheng, Y.; Zhu, X.; Zhukov, V.; Zonneveld, J. B.; Zucchelli, S.; LHCb Collaboration

2018-03-01

A measurement is reported of the ratio of branching fractions R (J /ψ ) =B (Bc+→J /ψ τ+ντ)/B (Bc+→J /ψ μ+νμ) , where the τ+ lepton is identified in the decay mode τ+→μ+νμν¯τ. This analysis uses a sample of proton-proton collision data corresponding to 3.0 fb-1 of integrated luminosity recorded with the LHCb experiment at center-of-mass energies of 7 and 8 TeV. A signal is found for the decay Bc+→J /ψ τ+ντ at a significance of 3 standard deviations corrected for systematic uncertainty, and the ratio of the branching fractions is measured to be R (J /ψ ) =0.71 ±0.17 (stat ) ±0.18 (syst ) . This result lies within 2 standard deviations above the range of central values currently predicted by the standard model.

Modified spin-wave theory with ordering vector optimization: spatially anisotropic triangular lattice and J1J2J3 model with Heisenberg interactions

NASA Astrophysics Data System (ADS)

Hauke, Philipp; Roscilde, Tommaso; Murg, Valentin; Cirac, J. Ignacio; Schmied, Roman

2011-07-01

We study the ground-state phases of the S=1/2 Heisenberg quantum antiferromagnet on the spatially anisotropic triangular lattice (SATL) and on the square lattice with up to next-next-nearest-neighbor coupling (the J1J2J3 model), making use of Takahashi's modified spin-wave (MSW) theory supplemented by ordering vector optimization. We compare the MSW results with exact diagonalization and projected-entangled-pair-states calculations, demonstrating their qualitative and quantitative reliability. We find that the MSW theory correctly accounts for strong quantum effects on the ordering vector of the magnetic phases of the models under investigation: in particular, collinear magnetic order is promoted at the expense of non-collinear (spiral) order, and several spiral states that are stable at the classical level disappear from the quantum phase diagram. Moreover, collinear states and non-collinear ones are never connected continuously, but they are separated by parameter regions in which the MSW theory breaks down, signaling the possible appearance of a non-magnetic ground state. In the case of the SATL, a large breakdown region appears also for weak couplings between the chains composing the lattice, suggesting the possible occurrence of a large non-magnetic region continuously connected with the spin-liquid state of the uncoupled chains. This shows that the MSW theory is—despite its apparent simplicity—a versatile tool for finding candidate regions in the case of spin-liquid phases, which are among prime targets for relevant quantum simulations.

Full-length genome sequence analysis of an avian leukosis virus subgroup J (ALV-J) as contaminant in live poultry vaccine: The commercial live vaccines might be a potential route for ALV-J transmission.

PubMed

Wang, P; Lin, L; Li, H; Shi, M; Gu, Z; Wei, P

2018-02-25

One avian leukosis virus subgroup J (ALV-J) strain was isolated from 67 commercial live poultry vaccines produced by various manufacturers during 2013-2016 in China. The complete genomes of the isolate were sequenced and it was found that the genes gag and pol of the strain were relatively conservative, while the gp85 gene of the strain GX14YYA1 had the highest similarities with a field strain GX14ZS14, which was isolated from the chickens of a farm that had once used the same vaccine as the one found to be contaminated with the GX14YYA1. This is the first report of ALV-J contaminant in live poultry vaccine in China. Our finding demonstrates that vaccination of the commercial live vaccines might be a potential new route for ALV-J transmission in chickens and highlights the need for more extensive monitoring of the commercial live vaccines in China. © 2018 Blackwell Verlag GmbH.

Emerging features of ER resident J-proteins in plants

PubMed Central

Ohta, Masaru; Takaiwa, Fumio

2014-01-01

J-proteins are co-chaperone components of the HSP70 system. J-proteins stimulate Hsp70ATPase activity, which is responsible for stabilizing the interaction of Hsp70 with client proteins. J-proteins are localized in various intracellular compartments including the cytoplasm, mitochondria and endoplasmic reticulum (ER). Five types of ER resident J-proteins (ERdjs) have been found in plants (P58, ERdj2, ERdj2A, ERdj3B and ERdj7). Rice OsERdj3A is located in the vacuole and protein storage vacuoles (PSV, PB-II) under conditions of ER stress. J-proteins that are localized to the vacuole or lysosome are not found in mammals and yeast, suggesting that the presence of OsERdj3A in the vacuole is plant-specific and one of the features unique to plant ERdjs. In this review, we summarize the current state of knowledge and recent research advancements regarding plant ERdjs, and compare mammalian and yeast ERdjs with plant ERdjs. PMID:24614601

FERMI Large Area Telescope Detection of Pulsed γ-Rays from the Vela-Like Pulsars PSR J1048–5832 and PSR J2229+6114

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2009-11-11

Within this paper, we report the detection of γ-ray pulsations (≥0.1 GeV) from PSR J2229+6114 and PSR J1048–5832, the latter having been detected as a low-significance pulsar by EGRET. Data in the γ-ray band were acquired by the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope, while the radio rotational ephemerides used to fold the γ-ray light curves were obtained using the Green Bank Telescope, the Lovell telescope at Jodrell Bank, and the Parkes Telescope. The two young radio pulsars, located within the error circles of the previously unidentified EGRET sources 3EG J1048–5840 and 3EG J2227+6122, present spin-downmore » characteristics similar to the Vela pulsar. PSR J1048–5832 shows two sharp peaks at phases 0.15 ± 0.01 and 0.57 ± 0.01 relative to the radio pulse confirming the EGRET light curve, while PSR J2229+6114 presents a very broad peak at phase 0.49 ± 0.01. The γ-ray spectra above 0.1 GeV of both pulsars are fit with power laws having exponential cutoffs near 3 GeV, leading to integral photon fluxes of (2.19 ± 0.22 ± 0.32) × 10 –7 cm –2 s –1 for PSR J1048–5832 and (3.77 ± 0.22 ± 0.44) × 10 –7 cm –2 s –1 for PSR J2229+6114. The first uncertainty is statistical and the second is systematic. PSR J1048–5832 is one of the two LAT sources which were entangled together as 3EG J1048–5840. In conclusion, these detections add to the growing number of young γ-ray pulsars that make up the dominant population of GeV γ-ray sources in the Galactic plane.« less

Wallerian degeneration in C57BL/6J and A/J mice: differences in time course of neurofilament and myelin breakdown, macrophage recruitment and iNOS expression

PubMed Central

de la Hoz, Cristiane L R; Oliveira, Alexandre L R; de S Queiroz, Luciano; Langone, Francesco

2003-01-01

The lower regeneration potential reported for C57BL/6J mice strain after peripheral nerve lesion may result from alterations in crucial events during Wallerian degeneration. We analysed neurofilament and myelin breakdown, macrophage recruitment, NADPH-diaphorase reaction and inducible nitric oxide synthase (iNOS) expression in transected sciatic nerves of C57BL/6J and A/J mice. The neurofilament volume density was lower in C57BL/6J strain mice at 1 and 3 days after lesion, and later equalled the density observed in A/J. C57BL/6J mice presented a high number of cells containing myelin debris, 3 and 5 days after the lesion. In both strains iNOS immunoreactivity was intense in macrophages and less evident in Schwann cells. However, a delay in macrophage recruitment and a lower percentage of iNOS-expressing macrophages on the third day were observed in C57BL/6J mice. NADPH-diaphorase reaction disclosed a similar pattern for both strains until the seventh day. However, at 5 days, cells with slender processes involving ellipsoid segments showed a well-defined cytoplasmic labelling in C57BL/6J whereas in A/J most of these cells exhibited a more granular and disperse labelling. We propose that these differences between A/J and C57BL/6J strains during Wallerian degeneration may be implicated in the lower regeneration potential observed in the latter. PMID:14686692

Testing for the J-2X Upper Stage Engine

NASA Technical Reports Server (NTRS)

Buzzell, James C.

2010-01-01

NASA selected the J-2X Upper Stage Engine in 2006 to power the upper stages of the Ares I crew launch vehicle and the Ares V cargo launch vehicle. Based on the proven Saturn J-2 engine, this new engine will provide 294,000 pounds of thrust and a specific impulse of 448 seconds, making it the most efficient gas generator cycle engine in history. The engine's guiding philosophy emerged from the Exploration Systems Architecture Study (ESAS) in 2005. Goals established then called for vehicles and components based, where feasible, on proven hardware from the Space Shuttle, commercial, and other programs, to perform the mission and provide an order of magnitude greater safety. Since that time, the team has made unprecedented progress. Ahead of the other elements of the Constellation Program architecture, the team has progressed through System Requirements Review (SRR), System Design Review (SDR), Preliminary Design Review (PDR), and Critical Design Review (CDR). As of February 2010, more than 100,000 development engine parts have been ordered and more than 18,000 delivered. Approximately 1,300 of more than 1,600 engine drawings were released for manufacturing. A major factor in the J-2X development approach to this point is testing operations of heritage J-2 engine hardware and new J-2X components to understand heritage performance, validate computer modeling of development components, mitigate risk early in development, and inform design trades. This testing has been performed both by NASA and its J-2X prime contractor, Pratt & Whitney Rocketdyne (PWR). This body of work increases the likelihood of success as the team prepares for testing the J-2X powerpack and first development engine in calendar 2011. This paper will provide highlights of J-2X testing operations, engine test facilities, development hardware, and plans.

Optical follow-up of AGL J2251-1239

NASA Astrophysics Data System (ADS)

Nesci, Roberto

2018-01-01

The AGILE Gamma-ray satellite reported a flaring source (AGL J2251-1239) at RA=342.83, DEC=-12.66 deg. (J2000) in two recent occasions, ATel #11043 (Dec 8, 2017, Lucarelli et al.) and ATel #11127 (Jan 4, 2018, Piano et al.).

Déjà vu: possible parahippocampal mechanisms.

PubMed

Spatt, Josef

2002-01-01

Déjà vu experiences are common in normal subjects. In addition, they are established symptoms of temporal lobe seizures. The author argues that the phenomenon is the result of faulty and isolated activity of a recognition memory system that consists of the parahippocampal gyrus and its neocortical connections. This memory system is responsible for judgments of familiarity. The result is that a momentary perceived scene is given the characteristics of familiarity that normally accompany a conscious recollection. The normal functioning of other brain structures involved in memory retrieval--the prefrontal cortex and the hippocampus proper--leads to the perplexing phenomenological quality of déjà vu. The hypothesis accounts for many characteristics of déjà vu in healthy subjects and is well fitting with experimental findings in patients with epilepsy.

Many Faces of Déjà Vu: a Narrative Review.

PubMed

Bošnjak Pašić, Marija; Horvat Velić, Emina; Fotak, Luka; Pašić, Hanna; Srkalović Imširagić, Azijada; Milat, Davorka; Šarac, Helena; Bjedov, Sarah; Petelin GadŽe, Željka

2018-03-01

French expression standing for the phrase "already seen" is a déjà vu. It is thought that as much as 97% of the population have experienced déjà vu at least once in their lifetime and 67% experience it regularly. The explanations of this phenomenon in novels and poems include reincarnation, dreams, organic factors, and unconscious memories. In this narrative review connection between déjà vu and various other conditions has been mentioned: false memories, temporal lobe epilepsy and other neurological conditions. In psychiatric patients déjà vu phenomenon is more often seen in patients with anxiety and people with derealisation/ depersonalization. It seems that temporal region is the origin of déjà vu phenomena in both healthy individuals and in individuals with neurological and psychiatric conditions, but the exact mechanism of this phenomenon is however still unknown. More attention should also be given to déjà vu from philosophical and religious perspectives as well. Déjà vu is still an enigma which could only be revealed with multidisciplinary approach through cooperation between neurologists, brain scientists, psychiatrists and experimental psychologists.

Expression and Significance of Cyclophilin J in Primary Gastric Adenocarcinoma.

PubMed

Gong, Zhaohua; Mu, Yuling; Chen, Jian; Chu, Hongjin; Lian, Peiwen; Wang, Congcong; Wang, Jiahui; Jiang, Lixin

2017-08-01

Biomarkers are essential in early diagnosis and understanding of the molecular mechanism of human cancer. The expression of cyclophilin J, a novel member of the cyclophilin family, was investigated in primary gastric adenocarcinoma. Western blot analysis was carried out on 36 paired tumor and normal tissue samples; immunohistochemical analysis was carried out on 120 gastric carcinoma tissues and normal adjacent tissue. Cyclophilin J protein was overexpressed in 72.2% of gastric carcinoma tissues compared to adjacent normal tissues. Immunohistochemical analysis revealed that cyclophilin J was overexpressed in 49.2% (59/120) and 23.3% (28/120) of gastric carcinoma tissues and adjacent tissues, respectively (p<0.05). Expression of cyclophilin J was associated with the degree of differentiation, but not with lymph node metastasis, gender or depth of tumor infiltration. The overall survival of patients showed no association with the overexpression of cyclophilin J protein. Cyclophilin J expression was up-regulated in gastric carcinoma compared to normal gastric tissues. However, in order to confirm its association with the survival of patients with gastric cancer, more cases need to be studied. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Radio Detection of LAT PSRs J1741-2054 and J2032+4127: No Longer Just Gamma-Ray Pulsars

DOE PAGES

Camilo, F.; Ray, P. S.; Ransom, S. M.; ...

2009-10-07

We present that sixteen pulsars have been discovered so far in blind searches of photons collected with the Large Area Telescope on the Fermi Gamma-ray Space Telescope. We here report the discovery of radio pulsations from two of them. PSR J1741-2054, with period P = 413 ms, was detected in archival Parkes telescope data and subsequently has been detected at the Green Bank Telescope (GBT). Its received flux varies greatly due to interstellar scintillation and it has a very small dispersion measure of DM = 4.7 pc cm –3, implying a distance of ≈0.4 kpc and possibly the smallest luminosity of any known radio pulsar. At this distance, for isotropic emission, its gamma-ray luminosity above 0.1 GeV corresponds to 28% of the spin-down luminosity ofmore » $$\\dot{E} = 9.4\\times 10^{33}$$ erg s–1. The gamma-ray profile occupies 1/3 of pulse phase and has three closely spaced peaks with the first peak lagging the radio pulse by δ = 0.29 P. We have also identified a soft Swift source that is the likely X-ray counterpart. In many respects PSR J1741-2054 resembles the Geminga pulsar. The second source, PSR J2032+4127, was detected at the GBT. It has P = 143 ms, and its DM = 115 pc cm –3 suggests a distance of ≈3.6 kpc, but we consider it likely that it is located within the Cyg OB2 stellar association at half that distance. The radio emission is nearly 100% linearly polarized, and the main radio peak precedes by δ = 0.15 P the first of two narrow gamma-ray peaks that are separated by Δ = 0.50 P. The second peak has a harder spectrum than the first one, following a trend observed in young gamma-ray pulsars. Faint, diffuse X-ray emission in a Chandra image is possibly its pulsar wind nebula. Finally, the wind of PSR J2032+4127 is responsible for the formerly unidentified HEGRA source TeV J2032+4130. PSR J2032+4127 is coincident in projection with MT91 213, a Be star in Cyg OB2, although apparently not a binary companion of it.« less

Search for hc→π+π-J /ψ via ψ (3686 )→π0π+π-J /ψ

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Ai, X. C.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Ferroli, R. Baldini; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, P. L.; Chen, S. J.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fang, J.; Fang, S. S.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guo, A. Q.; Guo, R. P.; Guo, Y. P.; Haddadi, Z.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, X. Q.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, H. M.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Andersson, W. Ikegami; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. W.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jie, Q. L.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kiese, P.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Lavezzi, L.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, Kang; Li, Ke; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. M.; Liu, Huanhuan; Liu, Huihui; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqing; Loehner, H.; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales, C. Morales; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, J. J.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ripka, M.; Rong, G.; Rosner, Ch.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, J. J.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, Dan; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiong, X. A.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Yang; Zhang, Yao; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, J.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2018-03-01

Using a data sample of 448.1 ×106 ψ (3686 ) events collected with the BESIII detector operating at the BEPCII, we perform search for the hadronic transition hc→π+π-J /ψ via ψ (3686 )→π0hc. No signals of the transition are observed, and the upper limit on the product branching fraction B (ψ (3686 )→π0hc)B (hc→π+π-J /ψ ) at the 90% confidence level (C.L.) is determined to be 2.0 ×10-6. This is the most stringent upper limit to date.

Performance of J-33-A-21 and J-33-A-23 Compressors with and without Water Injection

NASA Technical Reports Server (NTRS)

Beede, William L.

1948-01-01

In an investigation of the J-33-A-21 and the J-33-A-23 compressors with and without water injection, it was discovered that the compressors reacted differently to water injection although they were physically similar. An analysis of the effect of water injection on compressor performance and the consequent effect on matching of the compressor and turbine components in the turbojet engine was made. The analysis of component matching is based on a turbine flow function defined as the product of the equivalent weight flow and the reciprocal of the compressor pressure ratio.

RXTE PCA Detection of a New Outburst of XTE J1728-295 (probably IGR J17285-2922)

NASA Astrophysics Data System (ADS)

Markwardt, Craig B.; Swank, Jean H.

2010-08-01

We report the detection of a new outburst of a source designated XTE J1728-295 in the RXTE PCA scans, which is probably the same as IGR J17285-2922. This source was first detected in August-October 2003 with PCA scans of the galactic center region, and is speculated to be a black hole candidate (Barlow et al. 2005, A&A, 437, L27). In PCA scans on 2010-08-28 near 09:35 UTC, the source rose to a flux of 6.5 mCrab (2-10 keV).

Analysis of a Non-Developing Tropical Circulation System During the Tropical Cyclone Structure (TCS08) Field Experiment

DTIC Science & Technology

2009-12-01

Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaigns (T- PARC ). Aircraft dropwindsondes, special ELDORA radar observations...systems within TCS025 at 2030 UTC 24 August 2008. D. ELDORA BACKGROUND For the combined TCS08 and T- PARC field experiment, the ELDORA radar was...SUBJECT TERMS Electra Doppler Radar (ELDORA), Tropical Cyclone Structure (TCS08), TCS08, Tropical Cyclone Formation, Tropical Circulation System

40 CFR Appendix J to Part 75... - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 16 2011-07-01 2011-07-01 false [Reserved] J Appendix J to Part 75-Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures Protection of Environment... to Part 75—Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures...

40 CFR Appendix J to Part 75... - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] J Appendix J to Part 75-Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures Protection of Environment... to Part 75—Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures...

40 CFR Appendix J to Part 75... - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 17 2012-07-01 2012-07-01 false [Reserved] J Appendix J to Part 75-Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures Protection of Environment... to Part 75—Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures...

40 CFR Appendix J to Part 75... - [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false [Reserved] J Appendix J to Part 75-Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures Protection of Environment... to Part 75—Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures...

40 CFR Appendix J to Part 75... - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false [Reserved] J Appendix J to Part 75-Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures Protection of Environment... to Part 75—Compliance Dates for Revised Recordkeeping Requirements and Missing Data Procedures...

32 CFR Appendix J to Part 275 - Format for Customer Authorization

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Format for Customer Authorization J Appendix J... OF 1978 Pt. 275, App. J Appendix J to Part 275—Format for Customer Authorization Pursuant to section 3404(a) of the Right to Financial Privacy Act of 1978, I, [Name of customer], having read the...

Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.

PubMed

Ramos, Raddy L; Toia, Alyssa R; Pasternack, Daniel M; Dotzler, Timothy P; Cuoco, Joshua A; Esposito, Anthony W; Le, Megan M; Parker, Alexander K; Goodman, Jeffrey H; Sarkisian, Matthew R

2016-11-19

Subcortical band heterotopia (SBH) are malformations of the human cerebral cortex typically associated with epilepsy and cognitive delay/disability. Rodent models of SBH have demonstrated strong face validity as they are accompanied by both cognitive deficits and spontaneous seizures or reduced seizure threshold. BXD29-Tlr4 lps-2J /J recombinant inbred mice display striking bilateral SBH, partial callosal agenesis, morphological changes in subcortical structures of the auditory pathway, and display sensory deficits in behavioral tests (Rosen et al., 2013; Truong et al., 2013, 2015). Surprisingly, these mice show no cognitive deficits and have a higher seizure threshold to chemi-convulsive treatment (Gabel et al., 2013) making them different than other rodent SBH models described previously. In the present report, we perform a detailed characterization of the cellular and axonal constituents of SBH in BXD29-Tlr4 lps-2J /J mice and demonstrate that various types of interneurons and glia as well as cortical and subcortical projections are found in SBH. In addition, the length of neuronal cilia was reduced in SBH compared to neurons in the overlying and adjacent normotopic cortex. Finally, we describe additional and novel malformations of the hippocampus and neocortex present in BXD29-Tlr4 lps-2J /J mice. Together, our findings in BXD29-Tlr4 lps-2J /J mice are discussed in the context of the known neuroanatomy and phenotype of other SBH rodent models. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

The CO-12 and CO-13 J=2-1 and J=1-0 observations of hot and cold galaxies

NASA Technical Reports Server (NTRS)

Xie, Shuding; Schloerb, F. Peter; Young, Judith

1990-01-01

Researchers observed the nuclear regions of the galaxies NGC 2146 and IC 342 in CO-12 and CO-13 J=1-0 and J=2-1 lines using the Five College Radio Astronomy Observatory (FCRAO) 14m telescope. NGC 2146 is a peculiar Sab spiral galaxy. Its complex optical morphology and strong nuclear radio continuum emission suggest that it is experiencing a phase of violent activity and could have a polar ring which may have resulted from an interaction. IC 342 is a nearby luminous Scd spiral galaxy. Strong CO, infrared and radio continuum emission from the nuclear region of IC 342 indicate enhanced star-forming activity, and interferometric CO-12 J=1-0 observations reveal a bar-like structure centered on the nucleus, along the dark lane in the NS direction. These two galaxies are selected based on their different dust temperatures and star formation efficiencies (SFE) as derived from the Infrared Astronomy Satellite (IRAS) S sub 60 mu/S sub 100 mu flux density ratio and L sub IR/M(H2), respectively, with a relatively high SFE and dust temperature of 45 K in NGC 2146 and a relatively low SFE and dust temperature of 35 K in IC 342. The data from the different CO-12 and CO-13 lines are used to study the physical conditions in the molecular clouds in the galaxies. Researchers also consider the radiative transfer to determine whether a warm and optically thin gas component exists in these galaxies, as has been suggested in the case of M82 (Knapp et al. 1980), and whether the warm gas is related to the dust properties. Since optically thin CO-12 gas is rarely detected in our own Galaxy (except in outflow sources), to confirm its existence in external galaxies is very important in understanding the molecular content of external galaxies and its relationship to star formation activity. The present CO-12 J=2-1 and CO-13 J=2-1 and J=1-0 data for NGC 2146 are the first detections of this galaxy to our knowledge. The CO-12 J=1-0 distribution in NGC 2146 has been measured as part of the FCRAO

Rotational symmetry breaking toward a string-valence bond solid phase in frustrated J1 -J2 transverse field Ising model

NASA Astrophysics Data System (ADS)

Sadrzadeh, M.; Langari, A.

2018-06-01

We study the effect of quantum fluctuations by means of a transverse magnetic field (Γ) on the highly degenerate ground state of antiferromagnetic J1 -J2 Ising model on the square lattice, at the limit J2 /J1 = 0.5 . We show that harmonic quantum fluctuations based on single spin flips can not lift such degeneracy, however an-harmonic quantum fluctuations based on multi spin cluster flip excitations lift the degeneracy toward a unique ground state with string-valence bond solid (VBS) nature. A cluster operator formalism has been implemented to incorporate an-harmonic quantum fluctuations. We show that cluster-type excitations of the model lead not only to lower the excitation energy compared with a single-spin flip but also to lift the extensive degeneracy in favor of a string-VBS state, which breaks lattice rotational symmetry with only two fold degeneracy. The tendency toward the broken symmetry state is justified by numerical exact diagonalization. Moreover, we introduce a map to find the relation between the present model on the checkerboard and square lattices.

Rapid measurement of 3J(H N-H alpha) and 3J(N-H beta) coupling constants in polypeptides.

PubMed

Barnwal, Ravi Pratap; Rout, Ashok K; Chary, Kandala V R; Atreya, Hanudatta S

2007-12-01

We present two NMR experiments, (3,2)D HNHA and (3,2)D HNHB, for rapid and accurate measurement of 3J(H N-H alpha) and 3J(N-H beta) coupling constants in polypeptides based on the principle of G-matrix Fourier transform NMR spectroscopy and quantitative J-correlation. These experiments, which facilitate fast acquisition of three-dimensional data with high spectral/digital resolution and chemical shift dispersion, will provide renewed opportunities to utilize them for sequence specific resonance assignments, estimation/characterization of secondary structure with/without prior knowledge of resonance assignments, stereospecific assignment of prochiral groups and 3D structure determination, refinement and validation. Taken together, these experiments have a wide range of applications from structural genomics projects to studying structure and folding in polypeptides.

Optical spectroscopic followup of XMMSL1 J164303.7+653253 in the error box of IGR J16426+6536

NASA Astrophysics Data System (ADS)

Parisi, P.; Masetti, N.; Malizia, A.; Morelli, L.; Mason, E.; Dean, A. J.; Ubertini, P.

2008-10-01

We report on a spectroscopic observation of the optical object USNO-A2.0 1500-06133361 (with J2000 coordinates RA = 16 43 04.07, Dec = +65 32 50.9 and magnitude R ~ 18.9) inside the error circle of the XMM-Newton slew source XMMLS1 J164303.7+653253 (see Ibarra et al., ATel #1397), possibly associated with the unidentified INTEGRAL source IGR J16426+6536 (Bird et al. 2007, ApJS, 170, 175). The observations were performed on 2008 February 04, starting at 06:10 UT, with DOLORES, a focal reducer instrument installed on the 3.58m Telescopio Nazionale Galileo (TNG) in the Astronomical Observatory of Roque de Los Muchachos (Santa Cruz de La Palma, Spain), for a total exposure time of 1800 s.

29 CFR 102.94 - Expeditious processing of section 10(j) cases.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Expeditious processing of section 10(j) cases. 102.94..., SERIES 8 Procedure in Cases Under Section 10(j), (l), and (m) of the Act § 102.94 Expeditious processing of section 10(j) cases. (a) Whenever temporary relief or a restraining order pursuant to section 10(j...

Detection of X-ray flares from AX J1714.1-3912, the unidentified source near RX J1713.7-3946

NASA Astrophysics Data System (ADS)

Miceli, Marco; Bamba, Aya

2018-04-01

Context. Molecular clouds are predicted to emit nonthermal X-rays when they are close to particle-accelerating supernova remnants (SNRs), and the hard X-ray source AX J1714.1-3912, near the SNR RX J1713.7-3946, has long been considered a candidate for diffuse nonthermal emission associated with cosmic rays diffusing from the remnant to a closeby molecular cloud. Aim. We aim at ascertaining the nature of this source by analyzing two dedicated X-ray observations performed with Suzaku and Chandra. Methods: We extracted images from the data in various energy bands, spectra, and light curves and studied the long-term evolution of the X-ray emission on the basis of the 4.5 yr time separation between the two observations. Results: We found that there is no diffuse emission associated with AX J1714.1-3912, which is instead the point-like source CXOU J171343.9-391205. We discovered rapid time variability (timescale 103 s), together with a high intrinsic absorption and a hard nonthermal spectrum (power law with photon index Γ 1.4). We also found that the X-ray flux of the source drops down by 1-2 orders of magnitude on a timescale of a few years. Conclusions: Our results suggest a possible association between AX J1714.1-3912 and a previously unknown supergiant fast X-ray transient, although further follow-up observations are necessary to prove this association definitively.

Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells.

PubMed

Perry, Clint; Quissell, David O; Reyland, Mary E; Grichtchenko, Irina I

2008-11-01

Cholinergic agonists are major stimuli for fluid secretion in parotid acinar cells. Saliva bicarbonate is essential for maintaining oral health. Electrogenic and electroneutral Na(+)-HCO(3)(-) cotransporters (NBCe1 and NBCn1) are abundant in parotid glands. We previously reported that angiotensin regulates NBCe1 by endocytosis in Xenopus oocytes. Here, we studied cholinergic regulation of NBCe1 and NBCn1 membrane trafficking by confocal fluorescent microscopy and surface biotinylation in parotid epithelial cells. NBCe1 and NBCn1 colocalized with E-cadherin monoclonal antibody at the basolateral membrane (BLM) in polarized ParC5 cells. Inhibition of constitutive recycling with the carboxylic ionophore monensin or the calmodulin antagonist W-13 caused NBCe1 to accumulate in early endosomes with a parallel loss from the BLM, suggesting that NBCe1 is constitutively endocytosed. Carbachol and PMA likewise caused redistribution of NBCe1 from BLM to early endosomes. The PKC inhibitor, GF-109203X, blocked this redistribution, indicating a role for PKC. In contrast, BLM NBCn1 was not downregulated in parotid acinar cells treated with constitutive recycling inhibitors, cholinergic stimulators, or PMA. We likewise demonstrate striking differences in regulation of membrane trafficking of NBCe1 vs. NBCn1 in resting and stimulated cells. We speculate that endocytosis of NBCe1, which coincides with the transition to a steady-state phase of stimulated fluid secretion, could be a part of acinar cell adjustment to a continuous secretory response. Stable association of NBCn1 at the membrane may facilitate constitutive uptake of HCO(3)(-) across the BLM, thus supporting HCO(3)(-) luminal secretion and/or maintaining acid-base homeostasis in stimulated cells.

Effect of Environmental Enrichment on Aggression in BALB/cJ and BALB/cByJ Mice Monitored by Using an Automated System.

PubMed

Giles, Jareca M; Whitaker, Julia W; Moy, Sheryl S; Fletcher, Craig A

2018-04-18

Aggression among mice remains a common undesirable problem in laboratory settings, and animal welfare and scientific outcomes may become compromised depending on the severity of aggression. This study evaluated the effect of cage enrichment comprising a bilevel, mounted 'mezzanine' compared with a cotton square or shelter on intracage male aggression over a 6-wk period. Our first study involved home-cage behavioral challenges to male mice from a high aggression substrain (BALB/cJ) and low-aggression substrain (BALB/cByJ). Aggressive interactions and locomotor activity were scored manually and then compared with measures of activity obtained by using a continuous automated home-cagemonitoring system, the Digital Ventilated Caging (DVC) system. BALB/cJ mice exhibited similar levels of aggression acrosshousing conditions, whereas BALB/cByJ mice had lower aggression when housed with a mezzanine. In the second study,videorecordings and continuous DVC automated measures were collected over 24 h and divided into 12-h light and dark phases. BALB/cByJ mice-but not BALB/cJ-mice had increased aggressive behaviors during the dark phase. However, the DVC detected higher activity levels during the dark phase, compared with the light phase, in both substrains. Elevated activity levels recorded by the DVC correlated with fighting bouts and high levels of locomotion. These results show that a bilevel structural form of enrichment reduces aggression, depending on the BALB/c substrain, and confirms higher aggression levels in the BALB/cJ substrain. In addition, our findings provide evidence that the DVC is effective in identifying mouse cages with patterns of high activity levels, signaling possible aggression incidences, thus potentially allowing for early intervention and consequently improving animal welfare.

An energy-dependent numerical model for the condensation probability, γ j

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerby, Leslie Marie

The “condensation” probability, γ j, is an important variable in the preequilibrium stage of nuclear spallation reactions. It represents the probability that p j excited nucleons (excitons) will “condense” to form complex particle type j in the excited residual nucleus. In addition, it has a significant impact on the emission width, or probability of emitting fragment type j from the residual nucleus. Previous formulations for γ j were energy-independent and valid for fragments up to 4He only. This paper explores the formulation of a new model for γ j, one which is energy-dependent and valid for up to 28Mg, andmore » which provides improved fits compared to experimental fragment spectra.« less

An energy-dependent numerical model for the condensation probability, γ j

DOE PAGES

Kerby, Leslie Marie

2016-12-09

The “condensation” probability, γ j, is an important variable in the preequilibrium stage of nuclear spallation reactions. It represents the probability that p j excited nucleons (excitons) will “condense” to form complex particle type j in the excited residual nucleus. In addition, it has a significant impact on the emission width, or probability of emitting fragment type j from the residual nucleus. Previous formulations for γ j were energy-independent and valid for fragments up to 4He only. This paper explores the formulation of a new model for γ j, one which is energy-dependent and valid for up to 28Mg, andmore » which provides improved fits compared to experimental fragment spectra.« less

76 FR 2799 - Amendment of Jet Route J-93; CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-18

...; Airspace Docket No. 10-AWP-4] RIN 2120-AA66 Amendment of Jet Route J-93; CA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Jet Route J-93 in California between...) to amend J-93, (75 FR 66344). Interested parties were invited to participate in this rulemaking...

26 CFR 1.904(j)-0 - Outline of regulation provisions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Outline of regulation provisions. 1.904(j)-0 Section 1.904(j)-0 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Income from Sources Without the United States § 1.904(j)-0 Outline of...

Michael J. Meaney: Award for Distinguished Scientific Contributions

ERIC Educational Resources Information Center

American Psychologist, 2012

2012-01-01

Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…

Reduced Sodium Current in the Lateral Ventricular Wall Induces Inferolateral J-Waves.

PubMed

Meijborg, Veronique M F; Potse, Mark; Conrath, Chantal E; Belterman, Charly N W; De Bakker, Jacques M T; Coronel, Ruben

2016-01-01

J-waves in inferolateral leads are associated with a higher risk for idiopathic ventricular fibrillation. We aimed to test potential mechanisms (depolarization or repolarization dependent) responsible for inferolateral J-waves. We hypothesized that inferolateral J-waves can be caused by regional delayed activation of myocardium that is activated late during normal conditions. Computer simulations were performed to evaluate how J-point elevation is influenced by reducing sodium current conductivity (GNa), increasing transient outward current conductivity (Gto), or cellular uncoupling in three predefined ventricular regions (lateral, anterior, or septal). Two pig hearts were Langendorff-perfused with selective perfusion with a sodium channel blocker of lateral or anterior/septal regions. Volume-conducted pseudo-electrocardiograms (ECG) were recorded to detect the presence of J-waves. Epicardial unipolar electrograms were simultaneously recorded to obtain activation times (AT). Simulation data showed that conduction slowing, caused by reduced sodium current, in lateral, but not in other regions induced inferolateral J-waves. An increase in transient outward potassium current or cellular uncoupling in the lateral zone elicited slight J-point elevations which did not meet J-wave criteria. Additional conduction slowing in the entire heart attenuated J-waves and J-point elevations on the ECG, because of masking by the QRS. Experimental data confirmed that conduction slowing attributed to sodium channel blockade in the left lateral but not in the anterior/septal ventricular region induced inferolateral J-waves. J-waves coincided with the delayed activation. Reduced sodium current in the left lateral ventricular myocardium can cause inferolateral J-waves on the ECG.

Coherent J / ψ photoproduction in hadronic heavy-ion collisions

DOE PAGES

Zha, W.; Klein, S. R.; Ma, R.; ...

2018-04-19

Significant excesses of J/ yield at very low transverse momentum (p T < 0:3 GeV/c) were observed by the ALICE and STAR collaborations in peripheral hadronic A+A collisions. This is a Sign of coherent photoproduction of J/ψ in violent hadronic interactions. Theoretically, the photoproduction of J= in hadronic collisions raises questions about how spectator and non-spectator nucleons participate in the coherent reaction. We argue that the strong interactions in the overlapping region of incoming nuclei may disturb the coherent production, leaving room for different coupling assumptions. The destructive interference between photoproduction on ions moving in opposite directions also needs tomore » be included. This letter presents calculations of J/ψ production from coherent photon-nucleus (γ+A → J/ψ +A) interactions in hadronic A+A collisions at RHIC and LHC energies with both nucleus and spectator coupling hypotheses. The integrated yield of coherent J/ψ as a function of centrality is found to be significantly different, especially towards central collisions, for different coupling scenarios. Differential distributions as a function of transverse momentum, azimuthal angle and rapidity in different centrality bins are also shown, and found to be more sensitive to the Pomeron coupling than to the photon coupling. Lastly, these predictions call for future experimental measurements to help better understand the coherent interaction in hadronic heavy-ion collisions.« less

Coherent J /ψ photoproduction in hadronic heavy-ion collisions

NASA Astrophysics Data System (ADS)

Zha, W.; Klein, S. R.; Ma, R.; Ruan, L.; Todoroki, T.; Tang, Z.; Xu, Z.; Yang, C.; Yang, Q.; Yang, S.

2018-04-01

Significant excesses of J /ψ yield at very low transverse momentum (pT<0.3 GeV/c ) were observed by the ALICE and STAR collaborations in peripheral hadronic A +A collisions. This is a sign of coherent photoproduction of J /ψ in violent hadronic interactions. Theoretically, the photoproduction of J /ψ in hadronic collisions raises questions about how spectator and nonspectator nucleons participate in the coherent reaction. We argue that the strong interactions in the overlapping region of incoming nuclei may disturb the coherent production, leaving room for different coupling assumptions. The destructive interference between photoproduction on ions moving in opposite directions also needs to be included. This paper presents calculations of J /ψ production from coherent photon-nucleus (γ +A →J /ψ +A ) interactions in hadronic A +A collisions at BNL Relativistic Heavy Ion Collider and CERN Large Hadron Collider energies with both nucleus and spectator coupling hypotheses. The integrated yield of coherent J /ψ as a function of centrality is found to be significantly different, especially towards central collisions, for different coupling scenarios. Differential distributions as a function of transverse momentum, azimuthal angle, and rapidity in different centrality bins are also shown, and found to be more sensitive to the Pomeron coupling than to the photon coupling. These predictions call for future experimental measurements to help better understand the coherent interaction in hadronic heavy-ion collisions.

Coherent J / ψ photoproduction in hadronic heavy-ion collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zha, W.; Klein, S. R.; Ma, R.

Significant excesses of J/ yield at very low transverse momentum (p T < 0:3 GeV/c) were observed by the ALICE and STAR collaborations in peripheral hadronic A+A collisions. This is a Sign of coherent photoproduction of J/ψ in violent hadronic interactions. Theoretically, the photoproduction of J= in hadronic collisions raises questions about how spectator and non-spectator nucleons participate in the coherent reaction. We argue that the strong interactions in the overlapping region of incoming nuclei may disturb the coherent production, leaving room for different coupling assumptions. The destructive interference between photoproduction on ions moving in opposite directions also needs tomore » be included. This letter presents calculations of J/ψ production from coherent photon-nucleus (γ+A → J/ψ +A) interactions in hadronic A+A collisions at RHIC and LHC energies with both nucleus and spectator coupling hypotheses. The integrated yield of coherent J/ψ as a function of centrality is found to be significantly different, especially towards central collisions, for different coupling scenarios. Differential distributions as a function of transverse momentum, azimuthal angle and rapidity in different centrality bins are also shown, and found to be more sensitive to the Pomeron coupling than to the photon coupling. Lastly, these predictions call for future experimental measurements to help better understand the coherent interaction in hadronic heavy-ion collisions.« less

Evaluation of neutron total and capture cross sections on 99Tc in the unresolved resonance region

NASA Astrophysics Data System (ADS)

Iwamoto, Nobuyuki; Katabuchi, Tatsuya

2017-09-01

Long-lived fission product Technetium-99 is one of the most important radioisotopes for nuclear transmutation. The reliable nuclear data are indispensable for a wide energy range up to a few MeV, in order to develop environmental load reducing technology. The statistical analyses of resolved resonances were performed by using the truncated Porter-Thomas distribution, coupled-channels optical model, nuclear level density model and Bayes' theorem on conditional probability. The total and capture cross sections were calculated by a nuclear reaction model code CCONE. The resulting cross sections have statistical consistency between the resolved and unresolved resonance regions. The evaluated capture data reproduce those recently measured at ANNRI of J-PARC/MLF above resolved resonance region up to 800 keV.

A new scanning system for alpha decay events as calibration sources for range-energy relation in nuclear emulsion

NASA Astrophysics Data System (ADS)

Yoshida, J.; Kinbara, S.; Mishina, A.; Nakazawa, K.; Soe, M. K.; Theint, A. M. M.; Tint, K. T.

2017-03-01

A new scanning system named "Vertex picker" has been developed to rapid collect alpha decay events, which are calibration sources for the range-energy relation in nuclear emulsion. A computer-controlled optical microscope scans emulsion layers exhaustively, and a high-speed and high-resolution camera takes their micrographs. A dedicated image processing picks out vertex-like shapes. Practical operations of alpha decay search were demonstrated by emulsion sheets of the KEK-PS E373 experiment. Alpha decays of nearly 28 events were detected in eye-check work on a PC monitor per hour. This yield is nearly 20 times more effective than that by the conventional eye-scan method. The speed and quality is acceptable for the coming new experiment, J-PARC E07.

Pulsed-neutron imaging by a high-speed camera and center-of-gravity processing

NASA Astrophysics Data System (ADS)

Mochiki, K.; Uragaki, T.; Koide, J.; Kushima, Y.; Kawarabayashi, J.; Taketani, A.; Otake, Y.; Matsumoto, Y.; Su, Y.; Hiroi, K.; Shinohara, T.; Kai, T.

2018-01-01

Pulsed-neutron imaging is attractive technique in the research fields of energy-resolved neutron radiography and RANS (RIKEN) and RADEN (J-PARC/JAEA) are small and large accelerator-driven pulsed-neutron facilities for its imaging, respectively. To overcome the insuficient spatial resolution of the conunting type imaging detectors like μ NID, nGEM and pixelated detectors, camera detectors combined with a neutron color image intensifier were investigated. At RANS center-of-gravity technique was applied to spots image obtained by a CCD camera and the technique was confirmed to be effective for improving spatial resolution. At RADEN a high-frame-rate CMOS camera was used and super resolution technique was applied and it was recognized that the spatial resolution was futhermore improved.

Hadron production experiments

NASA Astrophysics Data System (ADS)

Popov, Boris A.

2013-02-01

The HARP and NA61/SHINE hadroproduction experiments as well as their implications for neutrino physics are discussed. HARP measurements have already been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve the atmospheric neutrino flux predictions and to help in the optimization of neutrino factory and super-beam designs. First measurements released recently by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment. Both HARP and NA61/SHINE experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

Lattice Calculations and the Muon Anomalous Magnetic Moment

NASA Astrophysics Data System (ADS)

Marinković, Marina Krstić

2017-07-01

Anomalous magnetic moment of the muon, a_{μ }=(g_{μ }-2)/2, is one of the most precisely measured quantities in particle physics and it provides a stringent test of the Standard Model. The planned improvements of the experimental precision at Fermilab and at J-PARC propel further reduction of the theoretical uncertainty of a_{μ }. The hope is that the efforts on both sides will help resolve the current discrepancy between the experimental measurement of a_{μ } and its theoretical prediction, and potentially gain insight into new physics. The dominant sources of the uncertainty in the theoretical prediction of a_{μ } are the errors of the hadronic contributions. I will discuss recent progress on determination of hadronic contributions to a_{μ } from lattice calculations.

Swift J1822.3-1606: Enhanced Swift-XRT position

NASA Astrophysics Data System (ADS)

Pagani, C.; Beardmore, A. P.; Kennea, J. A.

2011-07-01

Using 1046 s of XRT Photon Counting mode data and 1 UVOT image for Swift J1822.3-1606, we find an astrometrically corrected X-ray position (using the XRT-UVOT alignment and matching UVOT field sources to the USNO-B1 catalogue) of RA, Dec = 275.57500, -16.07412 which is equivalent to: RA (J2000): 18h 22m 18.00s Dec (J2000): -16d 04' 26.8" with an uncertainty of 1.8 arcsec (radius, 90% confidence).

Differences in the onset mode of ventricular tachyarrhythmia between patients with J wave in anterior leads and those with J wave in inferolateral leads.

PubMed

Kamakura, Tsukasa; Wada, Mitsuru; Ishibashi, Kohei; Inoue, Yuko Y; Miyamoto, Koji; Okamura, Hideo; Nagase, Satoshi; Noda, Takashi; Aiba, Takeshi; Yasuda, Satoshi; Shimizu, Wataru; Kamakura, Shiro; Kusano, Kengo

2017-04-01

The pathophysiological mechanism of J wave in anterior leads (A-leads) and inferolateral leads (L-leads) remains unclear. We investigated the onset mode and circadian distribution of ventricular tachyarrhythmia (VTA) episodes between patients with early repolarization syndrome (ERS) and Brugada syndrome (BrS). The study enrolled 35 patients with ERS and 52 patients with type 1 BrS with spontaneous ventricular fibrillation who were divided into 4 groups: ERS(A+L) (n = 15), patients with ERS who had a non-type 1 Brugada pattern electrocardiogram in any A-leads (second to fourth intercostal spaces) in control and/or after drug provocation tests; ERS(L) (n = 20), patients with ERS with J wave only in L-leads; BrS(A) (n = 24), patients with BrS without J wave in L-leads; and BrS(A+L) (n = 28), patients with BrS with J wave in L-leads. The onset mode of 206 VTAs obtained from electrocardiograms or implantable cardioverter-defibrillators and the circadian distribution of 352 VTAs were investigated in the 4 groups. Three groups with J wave in A-leads, ERS(A+L), BrS(A), and BrS(A+L), had higher incidences of nocturnal (63%, 43%, and 47%, respectively) and sudden onset VTAs (67%, 97%, and 86%, respectively) with longer coupling intervals of premature ventricular contractions (388.8, 397.3, and 385.6 ms, respectively) than the ERS(L) group with J wave only in L-leads (25%, P = .0019; 19%, P < .0001; and 330.6 ms, P = .0004, respectively), the last of which mainly displayed VTAs with a short-long-short sequence. The onset mode of VTAs was different between patients with J wave in A-leads and patients with J wave in only L-leads. The underlying mechanism of J wave may differ between A-leads and L-leads. Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Circulating ApoJ is closely associated with insulin resistance in human subjects.

PubMed

Seo, Ji A; Kang, Min-Cheol; Ciaraldi, Theodore P; Kim, Sang Soo; Park, Kyong Soo; Choe, Charles; Hwang, Won Min; Lim, Dong Mee; Farr, Olivia; Mantzoros, Christos; Henry, Robert R; Kim, Young-Bum

2018-01-01

Insulin resistance is a major risk factor for type 2 diabetes. ApolipoproteinJ (ApoJ) has been implicated in altered pathophysiologic states including cardiovascular and Alzheimer's disease. However, the function of ApoJ in regulation of glucose homeostasis remains unclear. This study sought to determine whether serum ApoJ levels are associated with insulin resistance in human subjects and if they change after interventions that improve insulin sensitivity. Serum ApoJ levels and insulin resistance status were assessed in nondiabetic (ND) and type 2 diabetic (T2D) subjects. The impacts of rosiglitazone or metformin therapy on serum ApoJ levels and glucose disposal rate (GDR) during a hyperinsulinemic/euglycemic clamp were evaluated in a separate cohort of T2D subjects. Total ApoJ protein or that associated with the HDL and LDL fractions was measured by immunoblotting or ELISA. Fasting serum ApoJ levels were greatly elevated in T2D subjects (ND vs T2D; 100±8.3 vs. 150.6±8.5AU, P<0.0001). Circulating ApoJ levels strongly correlated with fasting glucose, fasting insulin, HOMA-IR, and BMI. ApoJ levels were significantly and independently associated with HOMA-IR, even after adjustment for age, sex, and BMI. Rosiglitazone treatment in T2D subjects resulted in a reduction in serum ApoJ levels (before vs. after treatment; 100±13.9 vs. 77±15.2AU, P=0.015), whereas metformin had no effect on ApoJ levels. The change in ApoJ levels during treatment was inversely associated with the change in GDR. Interestingly, ApoJ content in the LDL fraction was inversely associated with HOMA-IR. Serum ApoJ levels are closely correlated with the magnitude of insulin resistance regardless of obesity, and decrease along with improvement of insulin resistance in response only to rosiglitazone in type 2 diabetes. Copyright © 2017 Elsevier Inc. All rights reserved.

XTE J1946+274 = GRO J1944+26: An Enigmatic Be/X-Ray Binary

NASA Technical Reports Server (NTRS)

Wilson, Colleen A.; Finger, Mark H.; Coe, M. J.; Negueruela, Ignacio

2003-01-01

XTE J1946+274 = GRO J1944+26 is a 15.8 s Be/X-ray pulsar discovered simultaneously in 1998 September with the Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory (CGRO) and the All-Sky Monitor (ASM) on the Rossi X-Ray Timing Explorer (RXTE). Here we present new results from BATSE and RXTE including a pulse timing analysis, spectral analysis, and evidence for an accretion disk. Our pulse timing analysis yielded an orbital period of 169.2 days, a moderate eccentricity 0.33, and implied a mass function of 9.7 solar masses. We observed evidence for an accretion disk, a correlation between measured spin-up rate and flux, which was fitted to obtain a distance estimate of 9.5 +/- 2.9 kpc. XTE J1946+274 remained active from 1998 September to 2001 July, undergoing 13 outbursts that were not locked in orbital phase. Comparing RXTE Proportional Counter Array observations from the initial bright outburst in 1998 and the last pair of outbursts in 2001, we found energy and intensity-dependent pulse profile variations in both outbursts and hardening spectra with increasing intensity during the fainter 2001 outbursts. In 2001 July, optical H alpha observations indicated that a density perturbation appeared in the Be disk as the X-ray outbursts ceased. We propose that the equatorial plane of the Be star is inclined with respect to the orbital plane in this system and that this inclination may be a factor in the unusual outburst behavior of the system.

HESS J1640-465 and HESS J1641-463: Two Intriguing TeV Sources in Light of New Fermi-LAT Observations

NASA Astrophysics Data System (ADS)

Lemoine-Goumard, M.; Grondin, M.-H.; Acero, F.; Ballet, J.; Laffon, H.; Reposeur, T.

2014-10-01

We report on γ-ray analysis of the region containing the bright TeV source HESS J1640-465 and the close-by TeV source HESS J1641-463 using 64 months of observations with the Fermi Large Area Telescope (LAT). Previously only one GeV source was reported in this region and was associated with HESS J1640-465. With an increased data set and the improved sensitivity afforded by the reprocessed data (P7REP) of the LAT, we now report the detection, morphological study, and spectral analysis of two distinct sources above 100 MeV. The softest emission in this region comes from the TeV source HESS J1641-463 which is well fitted with a power law of index Γ = 2.47 ± 0.05 ± 0.06 and presents no significant γ-ray signal above 10 GeV, which contrasts with its hard spectrum at TeV energies. The Fermi-LAT spectrum of the second TeV source, HESS J1640-465 is well described by a power-law shape of index Γ = 1.99 ± 0.04 ± 0.07 that links up naturally with the spectral data points obtained by the High Energy Stereoscopic System (H.E.S.S.). These new results provide new constraints concerning the identification of these two puzzling γ-ray sources.

First Characterization of Fluoroquinolone Resistance in Streptococcus suis▿

PubMed Central

Escudero, Jose Antonio; San Millan, Alvaro; Catalan, Ana; de la Campa, Adela G.; Rivero, Estefania; Lopez, Gema; Dominguez, Lucas; Moreno, Miguel Angel; Gonzalez-Zorn, Bruno

2007-01-01

We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria. PMID:17116660

Wrestling J. B. Nash.

ERIC Educational Resources Information Center

Ellis, Gary D.

This paper focuses on how between 1965 and the present, the field of recreation has and has not accomplished the goals of author and educator J. B. Nash's in regard to recreation, physical education, and health, focusing on public recreation sponsored by city governments, county governments, and special tax districts. The paper looks at Nash's…

28 CFR 0.29j - Law enforcement authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Law enforcement authority. 0.29j Section...-Office of the Inspector General § 0.29j Law enforcement authority. Subject to guidelines promulgated by...) Detect and assist in the prosecution of crimes in violation of the laws of the United States and to...

Evolving J waves prior to ventricular fibrillation postoperative coronary bypass.

PubMed

Kitazawa, Hitoshi; Wakasugi, Takayuki; Sugimoto, Tsutomu; Yamamoto, Kazuo; Yoshii, Shinpei; Aizawa, Yoshifusa

2011-01-01

A 74-year-old man without history of ventricular arrhythmias underwent coronary bypass surgery for 3-vessel disease. On the 4th postoperative day, he developed ventricular fibrillation (VF). His monitored ECG showed no elevation of the ST-segment and no prolongation of QT interval, but evolving J waves prior to VF were shown. These J waves gradually decreased after defibrillation. The subsequent angiography revealed patent grafts and normal left ventricular function. J waves reappeared in inferior leads when contrast medium was injected into the coronary artery. Therefore, evolving J wave can be a marker of latent ischemia and a predictor of VF.

STS-28/51J - OFFICIAL CREW INSIGNIA

NASA Image and Video Library

1985-09-06

S85-39862 (1 Sept. 1985) --- The 51-J mission insignia, designed by Atlantis's first crew, pays tribute to the Statue of Liberty and the ideas it symbolizes. The historical gateway figure bears additional significance for astronauts Karol J. Bobko, mission commander; and Ronald J. Grabe, pilot, both New York natives. Other members of the five-man crew, whose surnames encircle the artwork, are Robert L. Stewart and David C. Hilmers, mission specialists; and William A. Pailes, payload specialist. The NASA insignia design for space shuttle flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the forms of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, the change will be publicly announced. Photo credit: NASA

Photolysis rates in correlated overlapping cloud fields: Cloud-J 7.3c

DOE PAGES

Prather, M. J.

2015-08-14

A new approach for modeling photolysis rates ( J values) in atmospheres with fractional cloud cover has been developed and is implemented as Cloud-J – a multi-scattering eight-stream radiative transfer model for solar radiation based on Fast-J. Using observations of the vertical correlation of cloud layers, Cloud-J 7.3c provides a practical and accurate method for modeling atmospheric chemistry. The combination of the new maximum-correlated cloud groups with the integration over all cloud combinations by four quadrature atmospheres produces mean J values in an atmospheric column with root mean square (rms) errors of 4 % or less compared with 10–20 %more » errors using simpler approximations. Cloud-J is practical for chemistry–climate models, requiring only an average of 2.8 Fast-J calls per atmosphere vs. hundreds of calls with the correlated cloud groups, or 1 call with the simplest cloud approximations. Another improvement in modeling J values, the treatment of volatile organic compounds with pressure-dependent cross sections, is also incorporated into Cloud-J.« less

Observation of J/ψp Resonances Consistent with Pentaquark States in Λ_{b}^{0}→J/ψK^{-}p Decays.

PubMed

Aaij, R; Adeva, B; Adinolfi, M; Affolder, A; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Anderson, J; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; d'Argent, P; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Bel, L J; Bellee, V; Belloli, N; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bertolin, A; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Billoir, P; Bird, T; Birnkraut, A; Bizzeti, A; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borsato, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britsch, M; Britton, T; Brodzicka, J; Brook, N H; Bursche, A; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Campana, P; Campora Perez, D; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cavallero, G; Cenci, R; Charles, M; Charpentier, Ph; Chefdeville, M; Chen, S; Cheung, S-F; Chiapolini, N; Chrzaszcz, M; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collazuol, G; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Corvo, M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Dall'Occo, E; Dalseno, J; David, P N Y; Davis, A; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Dean, C-T; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Demmer, M; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Di Ruscio, F; Dijkstra, H; Donleavy, S; Dordei, F; Dorigo, M; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Färber, C; Farley, N; Farry, S; Fay, R; Ferguson, D; Fernandez Albor, V; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fohl, K; Fol, P; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Fu, J; Furfaro, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; García Pardiñas, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauld, R; Gavardi, L; Gazzoni, G; Geraci, A; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianelle, A; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gotti, C; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grillo, L; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Humair, T; Hussain, N; Hutchcroft, D; Hynds, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kecke, M; Kelsey, M; Kenyon, I R; Kenzie, M; Ketel, T; Khanji, B; Khurewathanakul, C; Klaver, S; Klimaszewski, K; Kochebina, O; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Kozeiha, M; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kurek, K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Likhomanenko, T; Liles, M; Lindner, R; Linn, C; Lionetto, F; Liu, B; Liu, X; Loh, D; Longstaff, I; Lopes, J H; Lucchesi, D; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusardi, N; Lusiani, A; Machefert, F; Maciuc, F; Maev, O; Maguire, K; Malde, S; Malinin, A; Manca, G; Mancinelli, G; Manning, P; Mapelli, A; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marino, P; Marks, J; Martellotti, G; Martin, M; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massafferri, A; Matev, R; Mathad, A; Mathe, Z; Matteuzzi, C; Mauri, A; Maurin, B; Mazurov, A; McCann, M; McCarthy, J; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Melnychuk, D; Merk, M; Milanes, D A; Minard, M-N; Mitzel, D S; Molina Rodriguez, J; Monroy, I A; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Moron, J; Morris, A B; Mountain, R; Muheim, F; Müller, J; Müller, K; Müller, V; Mussini, M; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nandi, A; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Ninci, D; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Ogilvy, S; Okhrimenko, O; Oldeman, R; Onderwater, C J G; Osorio Rodrigues, B; Otalora Goicochea, J M; Otto, A; Owen, P; Oyanguren, A; Palano, A; Palombo, F; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Pappalardo, L L; Pappenheimer, C; Parkes, C; Passaleva, G; Patel, G D; Patel, M; Patrignani, C; 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Zavertyaev, M; Zhang, L; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zucchelli, S

2015-08-14

Observations of exotic structures in the J/ψp channel, which we refer to as charmonium-pentaquark states, in Λ_{b}^{0}→J/ψK^{-}p decays are presented. The data sample corresponds to an integrated luminosity of 3 fb^{-1} acquired with the LHCb detector from 7 and 8 TeV pp collisions. An amplitude analysis of the three-body final state reproduces the two-body mass and angular distributions. To obtain a satisfactory fit of the structures seen in the J/ψp mass spectrum, it is necessary to include two Breit-Wigner amplitudes that each describe a resonant state. The significance of each of these resonances is more than 9 standard deviations. One has a mass of 4380±8±29 MeV and a width of 205±18±86 MeV, while the second is narrower, with a mass of 4449.8±1.7±2.5 MeV and a width of 39±5±19 MeV. The preferred J^{P} assignments are of opposite parity, with one state having spin 3/2 and the other 5/2.

Measurement of prompt J/ ψ pair production in pp collisions at = 7 Tev

NASA Astrophysics Data System (ADS)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Dragicevic, M.; Erö, J.; Fabjan, C.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Kiesenhofer, W.; Knünz, V.; Krammer, M.; Krätschmer, I.; Liko, D.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schöfbeck, R.; Strauss, J.; Taurok, A.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Gonzalez, J. Suarez; Alderweireldt, S.; Bansal, M.; Bansal, S.; Cornelis, T.; De Wolf, E. A.; Janssen, X.; Knutsson, A.; Luyckx, S.; Ochesanu, S.; Roland, B.; Rougny, R.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Blekman, F.; Blyweert, S.; D'Hondt, J.; Daci, N.; Heracleous, N.; Keaveney, J.; Kim, T. J.; Lowette, S.; Maes, M.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Onsem, G. 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S.; Kirschenmann, H.; Klanner, R.; Kogler, R.; Lange, J.; Lapsien, T.; Lenz, T.; Marchesini, I.; Ott, J.; Peiffer, T.; Pietsch, N.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Seidel, M.; Sibille, J.; Sola, V.; Stadie, H.; Steinbrück, G.; Troendle, D.; Usai, E.; Vanelderen, L.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; De Boer, W.; Descroix, A.; Dierlamm, A.; Feindt, M.; Frensch, F.; Giffels, M.; Hartmann, F.; Hauth, T.; Husemann, U.; Katkov, I.; Kornmayer, A.; Kuznetsova, E.; Pardo, P. Lobelle; Mozer, M. U.; Müller, Th.; Nürnberg, A.; Quast, G.; Rabbertz, K.; Ratnikov, F.; Röcker, S.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weiler, T.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. 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M.; Shukla, P.; Topkar, A.; Aziz, T.; Banerjee, S.; Chatterjee, R. M.; Dewanjee, R. K.; Dugad, S.; Ganguly, S.; Ghosh, S.; Guchait, M.; Gurtu, A.; Kole, G.; Kumar, S.; Maity, M.; Majumder, G.; Mazumdar, K.; Mohanty, G. B.; Parida, B.; Sudhakar, K.; Wickramage, N.; Bakhshiansohi, H.; Behnamian, H.; Etesami, S. M.; Fahim, A.; Goldouzian, R.; Jafari, A.; Khakzad, M.; Najafabadi, M. Mohammadi; Naseri, M.; Mehdiabadi, S. Paktinat; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Barbone, L.; Calabria, C.; Chhibra, S. S.; Colaleo, A.; Creanza, D.; De Filippis, N.; De Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Selvaggi, G.; Silvestris, L.; Singh, G.; Venditti, R.; Verwilligen, P.; Zito, G.; Abbiendi, G.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Primavera, F.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Travaglini, R.; Albergo, S.; Cappello, G.; Chiorboli, M.; Costa, S.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gallo, E.; Gonzi, S.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Tropiano, A.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Ferro, F.; Vetere, M. Lo; Robutti, E.; Tosi, S.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Gerosa, R.; Ghezzi, A.; Govoni, P.; Lucchini, M. T.; Malvezzi, S.; Manzoni, R. A.; Martelli, A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; de Fatis, T. Tabarelli; Buontempo, S.; Cavallo, N.; Di Guida, S.; Fabozzi, F.; Iorio, A. O. 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A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Piroué, P.; Quan, X.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zenz, S. C.; Zuranski, A.; Brownson, E.; Mendez, H.; Vargas, J. E. Ramirez; Alagoz, E.; Barnes, V. E.; Benedetti, D.; Bolla, G.; Bortoletto, D.; De Mattia, M.; Hu, Z.; Jha, M. K.; Jones, M.; Jung, K.; Kress, M.; Leonardo, N.; Pegna, D. Lopes; Maroussov, V.; Merkel, P.; Miller, D. H.; Neumeister, N.; Radburn-Smith, B. C.; Shi, X.; Shipsey, I.; Silvers, D.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Yoo, H. D.; Zablocki, J.; Zheng, Y.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Ecklund, K. M.; Geurts, F. J. M.; Li, W.; Michlin, B.; Padley, B. P.; Redjimi, R.; Roberts, J.; Zabel, J.; Betchart, B.; Bodek, A.; Covarelli, R.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Khukhunaishvili, A.; Miner, D. C.; Petrillo, G.; Vishnevskiy, D.; Ciesielski, R.; Demortier, L.; Goulianos, K.; Lungu, G.; Mesropian, C.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Lath, A.; Panwalkar, S.; Park, M.; Patel, R.; Rekovic, V.; Salur, S.; Schnetzer, S.; Seitz, C.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Rose, K.; Spanier, S.; York, A.; Bouhali, O.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Khotilovich, V.; Krutelyov, V.; Montalvo, R.; Osipenkov, I.; Pakhotin, Y.; Perloff, A.; Roe, J.; Rose, A.; Safonov, A.; Sakuma, T.; Suarez, I.; Tatarinov, A.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kovitanggoon, K.; Kunori, S.; Lee, S. W.; Libeiro, T.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Sharma, M.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Arenton, M. W.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Wood, J.; Gollapinni, S.; Harr, R.; Karchin, P. E.; Don, C. Kottachchi Kankanamge; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Carlsmith, D.; Cepeda, M.; Dasu, S.; Duric, S.; Friis, E.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Lazaridis, C.; Levine, A.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ross, I.; Sarangi, T.; Savin, A.; Smith, W. H.; Woods, N.

2014-09-01

Production of prompt J/ ψ meson pairs in proton-proton collisions at = 7 TeV is measured with the CMS experiment at the LHC in a data sample corresponding to an integrated luminosity of about 4.7 fb-1. The two J/ ψ mesons are fully reconstructed via their decays into μ + μ - pairs. This observation provides for the first time access to the high-transverse-momentum region of J/ ψ pair production where model predictions are not yet established. The total and differential cross sections are measured in a phase space defined by the individual J/ ψ transverse momentum ( p T J/ ψ ) and rapidity (| y J/ ψ |): | y J/ ψ | < 1.2 for p {T/J/ ψ } > 6.5 GeV/ c; 1.2 < | y J/ ψ | < 1.43 for a p T threshold that scales linearly with | y J/ ψ | from 6.5 to 4.5 GeV/ c; and 1.43 < | y J/ ψ | < 2.2 for p {T/J/ ψ } > 4.5 GeV/ c. The total cross section, assuming unpolarized prompt J/ ψ pair production is 1.49 ± 0.07 (stat) ±0.13 (syst) nb. Different assumptions about the J/ ψ polarization imply modifications to the cross section ranging from -31% to +27%. [Figure not available: see fulltext.

Observation of a peaking structure in the $$J/\\psi \\phi$$ mass spectrum from $$B^{\\pm} \\to J/\\psi \\phi K^{\\pm}$$ decays

DOE PAGES

Chatrchyan, Serguei

2014-05-22

A peaking structure in the J/psi phi mass spectrum near threshold is observed in B(+/-) to J/psi phi K(+/-) decays, produced in pp collisions at sqrt(s) = 7 TeV collected with the CMS detector at the LHC. The data sample, selected on the basis of the dimuon decay mode of the J/psi, corresponds to an integrated luminosity of 5.2 inverse femtobarns. Fitting the structure to an S-wave relativistic Breit-Wigner lineshape above a three-body phase-space nonresonant component gives a signal statistical significance exceeding five standard deviations. The fitted mass and width values are m = 4148.0 +- 2.4 (stat.) +- 6.3more » (syst.) MeV and Gamma = 28 +15 -11 (stat.) +- 19 (syst.) MeV, respectively. Evidence for an additional peaking structure at higher J/psi phi mass is also reported.« less

Postacute rehabilitation care for hip fracture: who gets the most care?

PubMed

Freburger, Janet K; Holmes, George M; Ku, Li-Jung E

2012-10-01

To determine the extent to which demographic and geographic disparities exist in postacute rehabilitation care (PARC) use after hip fracture. Cross-sectional analysis of 2 years (2005-06) of population-based hospital discharge data. All short-term acute care hospitals in four demographically and geographically diverse states (AZ, FL, NJ, WI). Individuals aged 65 and older (mean 82.9) admitted to the hospital with a hip fracture who survived their inpatient stay (N = 64,065). The sample was 75.1% female and 91.5% white, 5.8% Hispanic, and 2.7% black. Whether the participant received institutional PARC; for participants who did not receive institutional care, whether they received home health (HH) care; and for participants who received institutional care, whether they received skilled nursing facility (SNF) or inpatient rehabilitation facility (IRF) care. Multilevel logistic regression analyses were conducted to identify demographic and geographic disparities in PARC use. Considering PARC on a continuum from more to fewer hours of care per day (IRF→SNF→HH→no HH), minorities and individuals of lower socioeconomic status (SES) generally received a lower volume of care. Individuals on Medicaid or who were uninsured were less likely to receive institutional care (odds ratio (OR) = 0.23, 95% confidence interval (CI) = 0.18-0.30) and to receive HH (OR = 0.46, 95% CI = 0.30-0.70) and more likely to receive SNF than IRF care (OR = 2.03, 95% CI = 1.36-3.05). Hispanics were less likely to receive institutional care (OR = 0.70, 95% CI = 0.62-0.79), and Hispanics (OR = 1.31) and blacks (OR = 1.49) were more likely to receive SNF than IRF care. There were also geographic differences in PARC. Several demographic and geographic disparities in PARC use were identified. Future research should confirm these findings and further elucidate factors that contribute to the observed disparities. © 2012, Copyright the Authors Journal compilation © 2012, The

Study of the B + c → J/ΨD + s and B + c → J/ΨD* s + decays with the ATLAS detector

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2016-01-05

The decays B + c → J/ΨD + s and B + c → J/ΨD* s + are studied with the ATLAS detector at the LHC using a dataset corresponding to integrated luminosities of 4.9 and 20.6 fb –1 of pp collisions collected at centre-of-mass energies √s = 7 TeV and 8 TeV, respectively. Furthermore, signal candidates are identified through J/ψ → μ +μ - and D (*)+ s → Φπ +(γ/π 0) decays.

Maternal Weight Gain as a Predictor of Litter Size in Swiss Webster, C57BL/6J, and BALB/cJ mice.

PubMed

Finlay, James B; Liu, Xueli; Ermel, Richard W; Adamson, Trinka W

2015-11-01

An important task facing both researchers and animal core facilities is producing sufficient mice for a given project. The inherent biologic variability of mouse reproduction and litter size further challenges effective research planning. A lack of precision in project planning contributes to the high cost of animal research, overproduction (thus waste) of animals, and inappropriate allocation of facility resources. To examine the extent daily prepartum maternal weight gain predicts litter size in 2 commonly used mouse strains (BALB/cJ and C57BL/6J) and one mouse stock (Swiss Webster), we weighed ≥ 25 pregnant dams of each strain or stock daily from the morning on which a vaginal plug (day 0) was present. On the morning when dams delivered their pups, we recorded the weight of the dam, the weight of the litter itself, and the number of pups. Litter sizes ranged from 1 to 7 pups for BALB/cJ, 2 to 13 for Swiss Webster, and 5 to 11 for C57BL/6J mice. Linear regression models (based on weight change from day 0) demonstrated that maternal weight gain at day 9 (BALB/cJ), day 11 (Swiss Webster), or day 14 (C57BL/6J) was a significant predictor of litter size. When tested prospectively, the linear regression model for each strain or stock was found to be accurate. These data indicate that the number of pups that will be born can be estimated accurately by using maternal weight gain at specific or stock-specific time points.

Transverse Single Spin Asymmetry in \\varvec{J}/\\varvec{ψ } Production

NASA Astrophysics Data System (ADS)

Sonawane, Bipin; Misra, Anuradha; Padval, Siddhesh; Rawoot, Vaibhav

2018-05-01

We estimate transverse single spin asymmetry (TSSA) in electroproduction of J/ψ for J-Lab and EIC energies. We present estimates of TSSAs in J/ψ production within generalized parton model (GPM) using recent parametrizations of gluon Sivers function (GSF) and compare the results obtained using color singlet model (CSM) with those obtained using color evaporation model (CEM) of quarkonium production.

Structural Basis of J Cochaperone Binding and Regulation of Hsp70

PubMed Central

Jiang, Jianwen; Maes, E. Guy; Taylor, Alex B; Wang, Liping; Hinck, Andrew P; Lafer, Eileen M; Sousa, Rui

2007-01-01

The many protein processing reactions of the ATP-hydrolyzing Hsp70s are regulated by J cochaperones, which contain J domains that stimulate Hsp70 ATPase activity and accessory domains that present protein substrates to Hsp70s. We report the structure of a J domain complexed with a J responsive portion of a mammalian Hsp70. The J domain activates ATPase activity by directing the linker that connects the Hsp70 nucleotide binding domain (NBD) and substrate binding domain (SBD) towards a hydrophobic patch on the NBD surface. Binding of the J domain to Hsp70 displaces the SBD from the NBD, which may allow the SBD flexibility to capture diverse substrates. Unlike prokaryotic Hsp70, the SBD and NBD of the mammalian chaperone interact in the ADP state. Thus, while both nucleotides and J cochaperones modulate Hsp70 NBD:linker and NBD:SBD interactions, the intrinsic persistence of those interactions differs in different Hsp70s and this may optimize their activities for different cellular roles. PMID:17996706

Microgravity

NASA Image and Video Library

2001-01-24

An artist's concept of the Primary Atomic Clock Reference System (PARCS) plarned to fly on the International Space Station (ISS). PARCS will make even more accurate atomic time available to everyone, from physicists testing Einstein's Theory of Relativity, to hikers using the Global Positioning System to find their way. In ground-based atomic clocks, lasers are used to cool and nearly stop atoms of cesium whose vibrations are used as the time base. The microgravity of space will allow the atoms to be suspended in the clock rather than circulated in an atomic fountain, as required on Earth. PARCS is being developed by the Jet Propulsion Laboratory with principal investigators at the National Institutes of Standards and Technology and the University of Colorado, Boulder. See also No. 0103191

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.

PubMed

Nillegoda, Nadinath B; Stank, Antonia; Malinverni, Duccio; Alberts, Niels; Szlachcic, Anna; Barducci, Alessandro; De Los Rios, Paolo; Wade, Rebecca C; Bukau, Bernd

2017-05-15

Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for Hsp70. Substrate selection is further tuned by transient complexation between different classes of J-proteins, which expands the range of protein aggregates targeted by metazoan Hsp70 for disaggregation. We assessed the prevalence and evolutionary conservation of J-protein complexation and cooperation in disaggregation. We find the emergence of a eukaryote-specific signature for interclass complexation of canonical J-proteins. Consistently, complexes exist in yeast and human cells, but not in bacteria, and correlate with cooperative action in disaggregation in vitro. Signature alterations exclude some J-proteins from networking, which ensures correct J-protein pairing, functional network integrity and J-protein specialization. This fundamental change in J-protein biology during the prokaryote-to-eukaryote transition allows for increased fine-tuning and broadening of Hsp70 function in eukaryotes.

Ileal J-pouch vaginoplasty: reconstruction of a physiologic vagina with an ileal J-pouch.

PubMed

Schneider, Wolfgang; Nguyen-Thanh, Phuong; Dralle, Henning; Mirastschijski, Ursula

2009-06-01

Vaginal reconstruction has been performed for more than a century. Main complications are vaginal stenosis requiring dilatation, dyspareunia, excessive mucus secretion, and poor aesthetic and functional outcome. Here we report a new operation method modified after Baldwin for intestinal vaginoplasty in a patient with pelvic exenteration after spinal cell carcinoma of the vagina. Because of balanced liquid resorption and mucus secretion with sufficient vessel length in the terminal ileum, this intestinal segment was chosen. A J-pouch of distal ileum was constructed pedicled on the ileocolic artery and accompanying nervous plexus, transferred into the lower pelvis and sutured to the vaginal stump. One year follow-up showed a highly satisfied, sexually active patient, with adequate vaginal size, optimal lubrication and no molesting fecal odor. Terminal ileum J-pouch vaginoplasty is an optimal method for vaginal reconstruction providing a sufficient vaginal lumen and lubrication and thereby restoring patients' sexual life and increasing life quality.

Discrete contribution to {psi}{sup '}{yields}J/{psi}+{gamma}{gamma}

DOE Office of Scientific and Technical Information (OSTI.GOV)

He Zhiguo; Soto, Joan; Lu Xiaorui

2011-03-01

The decay mode {psi}(2S){yields}J/{psi}+{gamma}{gamma} is proposed in order to experimentally identify the effects of the coupling of charmonium states to the continuum D{bar D} states. To have a better understanding of such a two-photon decay process, in this work we restrict ourselves to investigate the contribution of the discrete part, in which the photons are mainly produced via the intermediate states {chi}{sub cJ}(nP). Besides calculating the resonance contributions of {chi}{sub cJ}(1P)(J=0,1,2), we also take into account the contributions of the higher excited states {chi}{sub cJ}(2P) and the interference effect among the 1P and 2P states. We find that the contributionmore » of the 2P states and the interference terms to the total decay width is very tiny. However, for specific regions of the Dalitz plot, off the resonance peaks, we find that these contributions are sizable and should also be accounted for. We also provide the photon spectrum and study the polarization of J/{psi}.« less

National Contingency Plan Subpart J

EPA Pesticide Factsheets

Subpart J of the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) directs EPA to prepare a schedule of dispersants, other chemicals, and oil spill mitigating devices and substances that may be used to remove or control oil discharges.

Notification: Northwest Indian Fisheries Commission’s Puget Sound Protection and Restoration Implementation cooperative agreements PA00J32201 and PA00J91201

EPA Pesticide Factsheets

May 27, 2016. The EPA OIG plans to begin preliminary research on the Northwest Indian Fisheries Commission’s (NWIFC’s) Puget Sound Protection and Restoration Implementation cooperative agreements PA00J32201 and PA00J91201.

Potential applicability of chymotrypsin-susceptible microcin J25 derivatives to food preservation.

PubMed

Pomares, María Fernanda; Salomón, Raúl A; Pavlova, Olga; Severinov, Konstantin; Farías, Ricardo; Vincent, Paula A

2009-09-01

Microcin J25 (MccJ25) is a 21-residue ribosomally synthesized lariat peptide antibiotic. MccJ25 is active against such food-borne disease-causing pathogens as Salmonella spp., Shigella spp., and Escherichia coli, including E. coli O157:H7 and non-O157 strains. MccJ25 is highly resistant to digestion by proteolytic enzymes present in the stomach and intestinal contents. MccJ25 would therefore remain active in the gastrointestinal tract, affecting normal intestinal microbiota, and this limits the potential use of MccJ25 as a food preservative. In the present paper, we describe a chymotrypsin-susceptible MccJ25 derivative with a mutation of Gly(12) to Tyr that retained almost full antibiotic activity and efficiently inhibited the growth of pathogenic Salmonella enterica serovar Newport and Escherichia coli O157:H7 in skim milk and egg yolk. However, unlike the wild-type MccJ25, the MccJ25(G12Y) variant was inactivated by digestive enzymes both in vitro and in vivo. To our knowledge, our results represent the first example of a rational modification of a microcin aimed at increasing its potential use in food preservation.

J-2X Powerpack hot-fire test

NASA Image and Video Library

2008-01-31

The first hot-fire test of the J-2X power pack 1A gas generator was performed Jan. 31 on the A-1 Test Stand at Stennis Space Center. Initial indications are that all test objectives were met. The test was designed as a 3.42-second helium spin start with gas generator ignition and it went the full scheduled duration. Test conductors reported a smooth start with normal shutdown and described the event as a 'good test.' The test was part of the early component testing for the new J-2X engine being built by NASA to power the Ares I and Ares V rockets that will carry humans back to the moon and on to Mars. It was performed as one in a series of 12 scheduled tests. Those tests began last November at Stennis, but the January 31 event represented the first hot-fire test. The Stennis tests are a critical step in the successful development of the J-2X engine.

SPECTRUM AND MORPHOLOGY OF THE TWO BRIGHTEST MILAGRO SOURCES IN THE CYGNUS REGION: MGRO J2019+37 AND MGRO J2031+41

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, A. A.; Abeysekara, U.; Linnemann, J. T.

2012-07-10

The Cygnus region is a very bright and complex portion of the TeV sky, host to unidentified sources and a diffuse excess with respect to conventional cosmic-ray propagation models. Two of the brightest TeV sources, MGRO J2019+37 and MGRO J2031+41, are analyzed using Milagro data with a new technique, and their emission is tested under two different spectral assumptions: a power law and a power law with an exponential cutoff. The new analysis technique is based on an energy estimator that uses the fraction of photomultiplier tubes in the observatory that detect the extensive air shower. The photon spectrum ismore » measured in the range 1-100 TeV using the last three years of Milagro data (2005-2008), with the detector in its final configuration. An F-test indicates that MGRO J2019+37 is better fit by a power law with an exponential cutoff than by a simple power law. The best-fitting parameters for the power law with exponential cutoff model are a normalization at 10 TeV of 7{sup +5}{sub -2} Multiplication-Sign 10{sup -10} s{sup -1} m{sup -2} TeV{sup -1}, a spectral index of 2.0{sup +0.5}{sub -1.0}, and a cutoff energy of 29{sup +50}{sub -16} TeV. MGRO J2031+41 shows no evidence of a cutoff. The best-fitting parameters for a power law are a normalization of 2.1{sup +0.6}{sub -0.6} Multiplication-Sign 10{sup -10} s{sup -1} m{sup -2} TeV{sup -1} and a spectral index of 3.22{sup +0.23}{sub -0.18}. The overall flux is subject to a {approx}30% systematic uncertainty. The systematic uncertainty on the power-law indices is {approx}0.1. Both uncertainties have been verified with cosmic-ray data. A comparison with previous results from TeV J2032+4130, MGRO J2031+41, and MGRO J2019+37 is also presented.« less

Spectrum and Morphology of the Two Brightest Milagro Sources in the Cygnus Region: MGRO J2019+37 and MGRO J2031+41

NASA Technical Reports Server (NTRS)

Abdo, A. A.; Abeysekara, U.; Allen, B, T.; Aune, T.; Berley, D.; Bonamente, E.; Christopher, G. E.; DeYoung, T.; Dingus, B. L.; Ellsworth, R. W.;

Spectrum and Morphology of the Two Brightest Milagro Sources in the Cygnus Region: MGRO J2019+37 and MGRO J2031+41

NASA Astrophysics Data System (ADS)

Abdo, A. A.; Abeysekara, U.; Allen, B. T.; Aune, T.; Berley, D.; Bonamente, E.; Christopher, G. E.; DeYoung, T.; Dingus, B. L.; Ellsworth, R. W.; Galbraith-Frew, J. G.; Gonzalez, M. M.; Goodman, J. A.; Hoffman, C. M.; Hüntemeyer, P. H.; Hui, C. M.; Kolterman, B. E.; Linnemann, J. T.; McEnery, J. E.; Mincer, A. I.; Morgan, T.; Nemethy, P.; Pretz, J.; Ryan, J. M.; Saz Parkinson, P. M.; Shoup, A.; Sinnis, G.; Smith, A. J.; Vasileiou, V.; Walker, G. P.; Williams, D. A.; Yodh, G. B.

2012-07-01

The Cygnus region is a very bright and complex portion of the TeV sky, host to unidentified sources and a diffuse excess with respect to conventional cosmic-ray propagation models. Two of the brightest TeV sources, MGRO J2019+37 and MGRO J2031+41, are analyzed using Milagro data with a new technique, and their emission is tested under two different spectral assumptions: a power law and a power law with an exponential cutoff. The new analysis technique is based on an energy estimator that uses the fraction of photomultiplier tubes in the observatory that detect the extensive air shower. The photon spectrum is measured in the range 1-100 TeV using the last three years of Milagro data (2005-2008), with the detector in its final configuration. An F-test indicates that MGRO J2019+37 is better fit by a power law with an exponential cutoff than by a simple power law. The best-fitting parameters for the power law with exponential cutoff model are a normalization at 10 TeV of 7+5 -2 × 10-10 s-1 m-2 TeV-1, a spectral index of 2.0+0.5 -1.0, and a cutoff energy of 29+50 -16 TeV. MGRO J2031+41 shows no evidence of a cutoff. The best-fitting parameters for a power law are a normalization of 2.1+0.6 -0.6 × 10-10 s-1 m-2 TeV-1 and a spectral index of 3.22+0.23 -0.18. The overall flux is subject to a ~30% systematic uncertainty. The systematic uncertainty on the power-law indices is ~0.1. Both uncertainties have been verified with cosmic-ray data. A comparison with previous results from TeV J2032+4130, MGRO J2031+41, and MGRO J2019+37 is also presented.

Precise gene editing of chicken Na+/H+ exchange type 1 (chNHE1) confers resistance to avian leukosis virus subgroup J (ALV-J).

PubMed

Lee, Hong Jo; Lee, Kyung Youn; Jung, Kyung Min; Park, Kyung Je; Lee, Ko On; Suh, Jeong-Yong; Yao, Yongxiu; Nair, Venugopal; Han, Jae Yong

2017-12-01

Avian leukosis virus subgroup J (ALV-J), first isolated in the late 1980s, has caused economic losses to the poultry industry in many countries. As all chicken lines studied to date are susceptible to ALV infection, there is enormous interest in developing resistant chicken lines. The ALV-J receptor, chicken Na + /H + exchange 1 (chNHE1) and the critical amino acid sequences involved in viral attachment and entry have already been characterized. However, there are no reported attempts to induce resistance to the virus by targeted genome modification of the receptor sequences. In an attempt to induce resistance to ALV-J infection, we used clustered regularly interspaced short palindromic repeats (CRISPR)-associated (CRISPR/Cas9)-based genome editing approaches to modify critical residues of the chNHE1 receptor in chicken cells. The susceptibility of the modified cell lines to ALV-J infection was examined using enhanced green fluorescent protein (EGFP)-expressing marker viruses. We showed that modifying the chNHE1 receptor by artificially generating a premature stop codon induced absolute resistance to viral infection, with mutations of the tryptophan residue at position 38 (Trp38) being very critical. Single-stranded oligodeoxynucleotide (ssODN)-mediated targeted recombination of the Trp38 region revealed that deletions involving the Trp38 residue were most effective in conferring resistance to ALV-J. Moreover, protein structure analysis of the chNHE1 receptor sequence suggested that its intrinsically disordered region undergoes local conformational changes through genetic alteration. Collectively, these results demonstrate that targeted mutations on chNHE1 alter the susceptibility to ALV-J and the technique is expected to contribute to develop disease-resistant chicken lines. Copyright © 2017 Elsevier Ltd. All rights reserved.

Pair production of J/ψ mesons in the kt-factorization approach

NASA Astrophysics Data System (ADS)

Baranov, S. P.

2011-09-01

In the framework of kt-factorization approach, we consider the production of J/ψ pairs at the LHC conditions. We give predictions on the differential cross sections and discuss the source and the size of theoretical uncertainties. We also present a comparison with collinear parton model showing a dramatic difference in the J/ψ transverse momentum spectrum and J/ψ-J/ψ azimuthal correlations. Finally, we give predictions on the polarization observables in the helicity and Collins-Soper systems.

Baicalin is an inhibitor of subgroup J avian leukosis virus infection.

PubMed

Qian, Kun; Kong, Zheng-Ru; Zhang, Jie; Cheng, Xiao-Wei; Wu, Zong-Yi; Gu, Cheng-Xi; Shao, Hong-Xia; Qin, Ai-Jian

2018-03-15

Avian leukosis virus subgroup J (ALV-J) can cause great economic losses to the poultry industry worldwide. Baicalin, one of the flavonoids present in S.baicalensis Georgi, has been shown to have antiviral activities. To investigate whether baicalin has antiviral effects on the infection of ALV-J in DF-1 cells, the cells were treated with baicalin at different time points. We found that baicalin could inhibit viral mRNA, protein levels and overall virus infection in a dose- and time-dependent manner using a variety of assays. Baicalin specifically targeted virus internalization and reduced the infectivity of ALV-J particles, but had no effect on the levels of major ALV-J receptor and virus binding to DF-1 cells. Collectively, these results suggest that baicalin might have potential to be developed as a novel antiviral agent for ALV-J infection. Copyright © 2018 Elsevier B.V. All rights reserved.

Revisiting the Gamma-Ray Source 2FGL J1823.8+4312

NASA Astrophysics Data System (ADS)

Stern, Daniel; Assef, Roberto J.

2013-02-01

One of the great challenges of gamma-ray astronomy is identifying the lower energy counterparts to these high-energy sources. Recently, in this journal, Massaro et al. attempted to find the counterpart of 2FGL J1823.8+4312, a gamma-ray active galactic nucleus (AGN) of uncertain type from the Second Fermi Large Area Telescope catalog. After considering mid-infrared data in the field from the Wide-field Infrared Survey Explorer (WISE), those authors conclude that the preferred identification of 2FGL J1823.8+4312 is WISE J182352.33+431452.5, despite the fact that the mid-infrared source is undetected at radio energies. They claim that WISE J182352.33+431452.5 constitutes the discovery of a new class of extragalactic X-ray source, either a radio-faint blazar or the prototype of a new class of active galaxy with an enigmatic spectral energy distribution. This conclusion is claimed to be independent of whether or not the WISE source is the actual counterpart to 2FGL J1823.8+4312. Based on a re-analysis of public data in this field and new spectroscopy from Palomar, we conclude that WISE J182352.33+431452.5 is a dust-reddened quasar at z = 0.560, a representative example of a very common extragalactic AGN class. Were WISE J182352.33+431452.5 to be associated with the gamma-ray emission, this would be an unusual and exciting discovery. However, we argue that 2FGL J1823.8+4312 is more likely associated with either WISE J182409.25+431404.7 or, more likely, WISE J182419.04+430949.6, two radio-loud sources in the field. The former is a radio-loud quasar and the latter is an optically variable source with a featureless blue spectrum.