Sample records for jaanus lass kalju

  1. Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance.

    PubMed

    Fan, Shaohua; Wang, Yanyan; Wang, Cun; Jin, Haojie; Wu, Zheng; Lu, Jun; Zhang, Zifeng; Sun, Chunhui; Shan, Qun; Wu, Dongmei; Zhuang, Juan; Sheng, Ning; Xie, Ying; Li, Mengqiu; Hu, Bin; Fang, Jingyuan; Zheng, Yuanlin; Qin, Wenxin

    2018-05-20

    Homo sapienslongevity assurance homolog 2 of yeast LAG1 (LASS2) is expressed mostly in human liver. Here, we explored roles of LASS2 in pathogenesis of hepatic steatosis. Hepatocyte-specific LASS2 knockout (LASS2 -/- ) mice were generated using Cre-LoxP system. LASS2 -/- and wild-type (WT) mice were fed with chow or high-fat diet (HFD). We found LASS2 -/- mice were resistant to HFD-induced hepatic steatosis and insulin resistance. In HFD-fed mice, LASS2 deficiency significantly inhibited p38 MAPK and ERK1/ERK2 signaling in mouse liver. This effect was mediated by a significant increase of V-ATPase activity and a decrease of ROS level. We also observed that elevated expression of LASS2 in mouse hepatocyte cell line AML12 obviously decreased V-ATPase activity and increased ROS level by activation of p38 MAPK and ERK1/ERK2 signaling. Our findings indicate that LASS2 plays an important role in the pathogenesis of diet-induced hepatic steatosis and is a potential novel target for prevention and intervention of liver diseases. Copyright © 2018 Elsevier Inc. All rights reserved.

  2. Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694.

    PubMed

    Lu, Xiaodong; Chen, Yuanyuan; Zeng, Tiantian; Chen, Lufang; Shao, Qixiang; Qin, Wenxin

    2014-12-01

    Homo sapiens longevity assurance homolog 2 of yeast LAG (Lass2) catalyzes the synthesis of long-chain ceramide which is an essential element of membranous structures. Deletion of Lass2 is associated with a high risk of spontaneous or DEN-induced hepatocellular carcinoma (HCC), yet the mechanism remains unclear. In the present study, we found extensive vesicles in hepatocytes of one-month-old Lass2-knockout (KO) mice. Hepatic biochemical indices were increased and expression of albumin was attenuated in the one‑month Lass2-KO liver. The results indicate that the injuries of the hepatocytes in young Lass2-KO mice, based on the results of Gene Ontology analysis of mRNA microarray of Lass2-KO liver vs. wild-type liver showed 'wounding response' was the mostly possible altered pathway in the Lass2-KO mice. miR-mRNA integrated analysis revealed that miR-694 was downregulated while its target gene tumor necrosis factor α-induced protein 3 (Tnfaip3) was upregulated, as confirmed by qPCR. The expression of NF-κB which is negatively controlled by Tnfaip3 was detected by qPCR and was found to be downregulated. Herein, we first report that Lass2 deficiency caused the downregulation of miR-694 and the upregulation of its target gene Tnfaip3 in vivo in mice, which may be related to a high risk of occurrence of HCC.

  3. An improved study of the kappa resonance and the non-exotic s wave πK scatterings up to √{s}=2.1 GeV of LASS data

    NASA Astrophysics Data System (ADS)

    Zhou, Z. Y.; Zheng, H. Q.

    2006-09-01

    We point out that the dispersion relation for the left-hand cut integral presented in one of our previous paper [H.Q. Zheng, et al., Nucl. Phys. A 733 (2004) 235] is actually free of subtraction constant, even for unequal mass elastic scatterings. A new fit to the LASS data [D. Aston, et al., LASS Collaboration, Nucl. Phys. B 296 (1988) 493] is performed and firm evidence for the existence of κ pole is found. The correct use of analyticity also put strong constraints on threshold parameters—which are found to be in good agreement with those obtained from chiral theories. We also determined the pole parameters of K0∗(1430) on the second sheet, and reconfirm the existence of K0∗(1950) on the third sheet. We stress that the LASS data do not require them to have the twin pole structure of a typical Breit-Wigner resonance.

  4. Data Reduction of Laser Ablation Split-Stream (LASS) Analyses Using Newly Developed Features Within Iolite: With Applications to Lu-Hf + U-Pb in Detrital Zircon and Sm-Nd +U-Pb in Igneous Monazite

    NASA Astrophysics Data System (ADS)

    Fisher, Christopher M.; Paton, Chad; Pearson, D. Graham; Sarkar, Chiranjeeb; Luo, Yan; Tersmette, Daniel B.; Chacko, Thomas

    2017-12-01

    A robust platform to view and integrate multiple data sets collected simultaneously is required to realize the utility and potential of the Laser Ablation Split-Stream (LASS) method. This capability, until now, has been unavailable and practitioners have had to laboriously process each data set separately, making it challenging to take full advantage of the benefits of LASS. We describe a new program for handling multiple mass spectrometric data sets collected simultaneously, designed specifically for the LASS technique, by which a laser aerosol is been split into two or more separate "streams" to be measured on separate mass spectrometers. New features within Iolite (https://iolite-software.com) enable the capability of loading, synchronizing, viewing, and reducing two or more data sets acquired simultaneously, as multiple DRSs (data reduction schemes) can be run concurrently. While this version of Iolite accommodates any combination of simultaneously collected mass spectrometer data, we demonstrate the utility using case studies where U-Pb and Lu-Hf isotope composition of zircon, and U-Pb and Sm-Nd isotope composition of monazite were analyzed simultaneously, in crystals showing complex isotopic zonation. These studies demonstrate the importance of being able to view and integrate simultaneously acquired data sets, especially for samples with complicated zoning and decoupled isotope systematics, in order to extract accurate and geologically meaningful isotopic and compositional data. This contribution provides instructions and examples for handling simultaneously collected laser ablation data. An instructional video is also provided. The updated Iolite software will help to fully develop the applications of both LASS and multi-instrument mass spectrometric measurement capabilities.

  5. Users guide for guidance and control Launch and Abort Simulation for Spacecraft (LASS), volume 1

    NASA Technical Reports Server (NTRS)

    Havig, T. F.; Backman, H. D.

    1972-01-01

    The mathematical models and computer program which are used to implement LASS are described. The computer program provides for a simulation of boost to orbit and abort capability from boost trajectories to a prescribed target. The abort target provides a decision point for engine shutdown from which the vehicle coasts to the vicinity of the selected abort recovery site. The simulation is a six degree of freedom simulation describing a rigid body. The vehicle is influenced by forces and moments from nondistributed aerodynamics. An adaptive autopilot is provided to control vehicle attitudes during powered and unpowered flight. A conventional autopilot is provided for study of vehicle during powered flight.

  6. Commissioning and Testing the 1970's Era LASS Solenoid Magnet in JLab's Hall D

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ballard, Joshua T.; Biallas, George H.; Brown, G.

    2015-06-01

    JLab refurbished and reconfigured the LASS1, 1.85m bore Solenoid and installed it as the principal analysis magnet for nuclear physics in the newly constructed, Hall D at Jefferson Lab. The magnet contains four superconducting coils within an iron yoke. The magnet was built in the early1970's at Stanford Linear Accelerator Center and used a second time at Los Alamos National Laboratory. The coils were extensively refurbished and individually tested by JLab. A new Cryogenic Distribution Box provides cryogens and their control valving, current distribution bus, and instrumentation pass-through. A repurposed CTI 2800 refrigerator system and new transfer line complete themore » system. We describe the re-configuration, the process and problems of re-commissioning the magnet and the results of testing the completed magnet.« less

  7. Spectroscopie Raman et Rayleigh stimulée des mélasses optiques unidimensionnelles (partie I)

    NASA Astrophysics Data System (ADS)

    Courtois, Jean-Yves

    stimulated Raman lines are homogeneously broadened, and that a stimulated Rayleigh structure appears on the spectra because of the probe-induced time modulation of the cooling force, which induces a modulation of the atomic momentum distribution. In the latter situation, the Raman structures are inhomogeneously broadened, and a recoil-induced resonance is predicted in the center of the spectrum. Its shape corresponds to the derivative of a Gaussian curve and its width is directly proportional to the Doppler width of the molasses. Finally, Section 6 presents a short review about the recent developments in the field of nonlinear spectroscopy of optical molasses. Cet article s'inscrit dans le double contexte de la spectroscopie non linéaire des milieux atomiques et de la physique du refroidissement d'atomes neutres par laser. Il présente une étude détaillée des spectres de transmission d'une onde sonde interagissant avec une mélasse optique unidimensionnelle. Plus précisément, nous montrons que dans chacun des deux cas modèles des mélasses “linperp lin” et “σ^+-σ^-” (ainsi dénommées par référence à la configuration de polarisation des deux faisceaux lasers à l'origine du mécanisme de refroidissement), les spectres pompes-sonde présentent des structures résonnantes pouvant s'interpréter en termes de diffusion Raman ou Rayleigh stimulée, et apportant un grand nombre d'informations sur les propriétés physiques des mélasses optiques. Cet article s'articule autour de deux grandes parties. Destinée à faire ultérieurement ressortir la spécificité des processus de diffusion stimulée se produisant dans les mélasses optiques, la première est consacrée à une présentation générale des processus Raman et Rayleigh stimulés se produisant dans les milieux atomiques et moléculaires conventionnels. L'effet Raman stimulé, lié à l'existence de centres diffuseurs ayant des états d'énergies et de populations différentes, fait l'objet du

  8. Mapping age and trace elements using laser ablation split-stream (LASS) ICPMS

    NASA Astrophysics Data System (ADS)

    Kylander-Clark, A. R.; Hacker, B. R.; Cottle, J. M.

    2012-12-01

    One of the biggest challenges in the determination of the timing and rates of metamorphic processes is tying the age of a particular mineral to the conditions (i.e., pressure, temperature, fluid composition) at which that phase grew. Conventional microbeam techniques increase our understanding of crustal evolution by enabling this linkage; e.g., x-ray maps of monazite allow us to pinpoint grain segments that grew under a different set of conditions, cathodoluminescence images of zircon reveal zoning patterns and hence targets for dating different metamorphic and/or igneous events, and rare-earth element (REE) transects across garnet reveal the budget of a variety of trace elements during a metamorphic episode, to name but a few. More recent advances in LA-ICPMS and SIMS have allowed the ability to produce age maps or trace element maps—thus further our understanding of crystallization processes—but not both. Here we employ laser ablation split-stream (LASS) to quantitatively image the age, and trace element signature of datable phases such as zircon, monazite, titanite, and rutile in metamorphic rocks on the micron scale. By mapping the age and TE signature of a metamorphic phase, we can better interpret the metamorphic stage at which all portions of that phase grew, and relate it to other phases/portions of phases within that rock, such as garnet. For example, zircons and monazites from from eclogites reveal complex zoning in REEs indicating growth prior to, during, and post eclogite-facies metamorphism; those zones correspond to distinct age domains. Metamorphosed titanite reveals differences in diffusivities of TEs in inherited portions of the grain; e.g., Pb-loss is more prominent than diffusion of REEs, which in turn diffuse faster than higher charged ions, such as Th.

  9. Single-Shot Laser Ablation Split-Stream (SS-LASS) Analysis Depth Profiling

    NASA Astrophysics Data System (ADS)

    Kylander-Clark, A. R.; Stearns, M. A.; Viete, D. R.; Cottle, J. M.; Hacker, B. R.

    2014-12-01

    Laser ablation depth profiling of geochronometers—such as zircon, monazite, titanite and rutile—has become popular in recent years as a tool to both determine date vs. depth or trace-element (TE) composition vs. depth; the former allows the dating of thin rims and, potentially, inversion of Pb-loss profiles for thermal histories, whereas the latter can yield insight into changes in PTX or mineral parageneses and inversion of trace-element profiles for thermal histories. In this study, we combine both techniques, enabling simultaneous acquisition of U-Th/Pb isotopic ratios and trace-element compositions, by joining a 193 nm excimer laser to a multi-collector ICP-MS and single-collector ICP-MS. The simultaneous acquisition allows direct shot-by-shot linkage between time and petrology, expanding our ability to understand the evolution of complex geologic systems. We construct each depth profile by capturing the analyte with a succession of individual laser pulses (each ~100 nm deep) . This has two main advantages over a typical time-dependent analysis of a multi-shot routine composed of tens to hundreds of shots and a several μm deep hole. 1) The reference material is analyzed between each shot for a more-accurate standardization of each aliquot of ablated material. 2) There is no mixing of material ablated from successive laser pulses during transmission to the ICP. The method is limited by count rate, which depends on spot size, excavation rate, instrument sensitivity, etc., and, for single-collector ICP, the switching time, which limits the number of elements that can be analyzed and their total counts. We explore the latter theoretically and experimentally to provide insight on both the ideal number of elements to measure and the dwell time in any given sample. Examples of the utility of SS-LASS include the comparison of apparent Pb loss to diffusion profiles of trace elements in rims of metamorphic rutile and titanite, as well as the determination of the

  10. Psychometric properties of a suicide screen for adjudicated youth in residential care.

    PubMed

    Langhinrichsen-Rohling, Jennifer; Hudson, Kenneth; Lamis, Dorian A; Carr, Nicole

    2012-04-01

    There is a need to efficiently and effectively screen adjudicated youth residing within the juvenile justice system for suicide proneness. Accordingly, in the current study, the psychometric properties of the Life Attitude Schedule: Short Form (LAS:S), a 24-item risk assessment for suicide proneness, were assessed using data from adjudicated youth residing in an alternative sentencing facility (n = 130). As predicted, statistically significant correlations were obtained between total LAS:S suicide proneness scores and reports of recent suicide ideation and hopelessness. Contrary to expectation, the previously reported 2-factor model for the LAS:S, with Factor 1 representing physical unhealthiness and Factor 2 representing psychological death, poorly fit the data. In adjudicated youth, we found that a single factor model derived from the 4 LAS:S subscales produced a better fit to the data than the 2-factor model. The death-related, self-related, injury-related, and negative health-related behaviors contained on the LAS:S shared common variance in these youth. A clinical implication is that practitioners can effectively use the total LAS:S score when screening adjudicated youth for suicide proneness.

  11. (U) Second-Order Sensitivity Analysis of Uncollided Particle Contributions to Radiation Detector Responses Using Ray-Tracing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Favorite, Jeffrey A.

    The Second-Level Adjoint Sensitivity System (2nd-LASS) that yields the second-order sensitivities of a response of uncollided particles with respect to isotope densities, cross sections, and source emission rates is derived in Refs. 1 and 2. In Ref. 2, we solved problems for the uncollided leakage from a homogeneous sphere and a multiregion cylinder using the PARTISN multigroup discrete-ordinates code. In this memo, we derive solutions of the 2nd-LASS for the particular case when the response is a flux or partial current density computed at a single point on the boundary, and the inner products are computed using ray-tracing. Both themore » PARTISN approach and the ray-tracing approach are implemented in a computer code, SENSPG. The next section of this report presents the equations of the 1st- and 2nd-LASS for uncollided particles and the first- and second-order sensitivities that use the solutions of the 1st- and 2nd-LASS. Section III presents solutions of the 1st- and 2nd-LASS equations for the case of ray-tracing from a detector point. Section IV presents specific solutions of the 2nd-LASS and derives the ray-trace form of the inner products needed for second-order sensitivities. Numerical results for the total leakage from a homogeneous sphere are presented in Sec. V and for the leakage from one side of a two-region slab in Sec. VI. Section VII is a summary and conclusions.« less

  12. Localized Ambient Solidity Separation Algorithm Based Computer User Segmentation.

    PubMed

    Sun, Xiao; Zhang, Tongda; Chai, Yueting; Liu, Yi

    2015-01-01

    Most of popular clustering methods typically have some strong assumptions of the dataset. For example, the k-means implicitly assumes that all clusters come from spherical Gaussian distributions which have different means but the same covariance. However, when dealing with datasets that have diverse distribution shapes or high dimensionality, these assumptions might not be valid anymore. In order to overcome this weakness, we proposed a new clustering algorithm named localized ambient solidity separation (LASS) algorithm, using a new isolation criterion called centroid distance. Compared with other density based isolation criteria, our proposed centroid distance isolation criterion addresses the problem caused by high dimensionality and varying density. The experiment on a designed two-dimensional benchmark dataset shows that our proposed LASS algorithm not only inherits the advantage of the original dissimilarity increments clustering method to separate naturally isolated clusters but also can identify the clusters which are adjacent, overlapping, and under background noise. Finally, we compared our LASS algorithm with the dissimilarity increments clustering method on a massive computer user dataset with over two million records that contains demographic and behaviors information. The results show that LASS algorithm works extremely well on this computer user dataset and can gain more knowledge from it.

  13. Predictors of Exercise-Induced Pulmonary Hypertension in Patients with Asymptomatic Degenerative Mitral Regurgitation: Mechanistic Insights from 2D Speckle-Tracking Echocardiography

    PubMed Central

    Kamijima, Ryo; Suzuki, Kengo; Izumo, Masaki; Kuwata, Shingo; Mizukoshi, Kei; Takai, Manabu; Kou, Seisyou; Hayashi, Akio; Kida, Keisuke; Harada, Tomoo; Akashi, Yoshihiro J.

    2017-01-01

    Presence of exercise-induced pulmonary hypertension (EIPH) in asymptomatic degenerative mitral regurgitation (DMR) determines prognosis. This study aimed to elucidate the mechanism and predictors of EIPH in asymptomatic DMR. Ninety-one consecutive asymptomatic patients with DMR who underwent exercise stress echocardiography were prospectively included. We obtained various conventional echocardiographic parameters at rest and during peak exercise, as well as left atrial (LA) function at rest using 2-dimensional speckle-tracking analysis. The 25 patients (33.3%) with EIPH were significantly older and had a greater ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity during peak exercise than those without EIPH. LA strain (LAS)-s and LAS-e, indices of LA reservoir and conduit function, respectively, were significantly lower in those with EIPH than in those without EIPH. Multivariate analysis indicated that LAS-s was the only resting echocardiographic parameter that independently predicted EIPH, with a cut-off value of 26.9%. Furthermore, Kaplan-Meier curve analysis showed that symptom-free survival was markedly lower among those with reduced LAS-s. In conclusion, decreased LA reservoir function contributes to EIPH, and LAS-s at rest is a useful indicator for predicting EIPH in asymptomatic patients with DMR. PMID:28071674

  14. Localized Ambient Solidity Separation Algorithm Based Computer User Segmentation

    PubMed Central

    Sun, Xiao; Zhang, Tongda; Chai, Yueting; Liu, Yi

    2015-01-01

    Most of popular clustering methods typically have some strong assumptions of the dataset. For example, the k-means implicitly assumes that all clusters come from spherical Gaussian distributions which have different means but the same covariance. However, when dealing with datasets that have diverse distribution shapes or high dimensionality, these assumptions might not be valid anymore. In order to overcome this weakness, we proposed a new clustering algorithm named localized ambient solidity separation (LASS) algorithm, using a new isolation criterion called centroid distance. Compared with other density based isolation criteria, our proposed centroid distance isolation criterion addresses the problem caused by high dimensionality and varying density. The experiment on a designed two-dimensional benchmark dataset shows that our proposed LASS algorithm not only inherits the advantage of the original dissimilarity increments clustering method to separate naturally isolated clusters but also can identify the clusters which are adjacent, overlapping, and under background noise. Finally, we compared our LASS algorithm with the dissimilarity increments clustering method on a massive computer user dataset with over two million records that contains demographic and behaviors information. The results show that LASS algorithm works extremely well on this computer user dataset and can gain more knowledge from it. PMID:26221133

  15. Learning Design at White Sands Test Facility

    NASA Technical Reports Server (NTRS)

    Grotewiel, Shane

    2010-01-01

    During the Fall of 2010, I spent my time at NASA White Sands Test Facility in Las Cruces, NM as an Undergraduate Student Research Program (USRP) Intern. During that time, I was given three projects to work on: Large Altitude Simulation System (LASS) basket strainer, log books, and the design of a case for touch screen monitors used for simulations. I spent most of my time on the LASS basket strainer. The LASS system has a water feed line with a basket strainer that filters out rust. In 2009, there were three misfires which cost approximately $27,000 and about 8% of the allotted time. The strainer was getting a large change in pressure that would result in a shutdown of the system. I have designed a new basket that will eliminate the large pressure change and it can be used with the old basket strainer housing. The LASS system has three steam generators (modules). Documents pertaining to these modules are stored electronically, and the majority of the documents are not able to be searched with keywords, so they have to be gone through one by one. I have come up with an idea on how to organize these files so that the Propulsion Department may efficiently search through the documents needed. Propulsion also has a LASS simulator that incorporates two touch screen monitors. Currently these monitors are in six foot by two foot metal cabinet on wheels. During simulation these monitors are used in the block house and need to be taken out of the block house when not in use. I have designed different options for hand held cases for storing and transporting the monitors in and out of the block house. The three projects previously mentioned demonstrate my contributions to the Propulsion Department and have taught me real world experience that is essential in becoming a productive engineer.

  16. Development of an analytical procedure to study linear alkylbenzenesulphonate (LAS) degradation in sewage sludge-amended soils.

    PubMed

    Comellas, L; Portillo, J L; Vaquero, M T

    1993-12-24

    A procedure for determining linear alkylbenzenesulphonates (LASs) in sewage sludge and amended soils has been developed. Extraction by sample treatment with 0.5 M potassium hydroxide in methanol and reflux was compared with a previously described extraction procedure in Soxhlet with methanol and solid sodium hydroxide in the sample. Repeatability results were similar with savings in extraction time, solvents and evaporation time. A clean-up method involving a C18 cartridge has been developed. Analytes were quantified by a reversed-phase HPLC method with UV and fluorescence detectors. Recoveries obtained were higher than 84%. The standing procedure was applied to high doses of sewage sludge-amended soils (15%) with increasing quantities of added LASs. Degradation data for a 116-day period are presented.

  17. Mapping gray-scale image to 3D surface scanning data by ray tracing

    NASA Astrophysics Data System (ADS)

    Li, Peng; Jones, Peter R. M.

    1997-03-01

    The extraction and location of feature points from range imaging is an important but difficult task in machine vision based measurement systems. There exist some feature points which are not able to be detected from pure geometric characteristics, particularly in those measurement tasks related to the human body. The Loughborough Anthropometric Shadow Scanner (LASS) is a whole body surface scanner based on structured light technique. Certain applications of LASS require accurate location of anthropometric landmarks from the scanned data. This is sometimes impossible from existing raw data because some landmarks do not appear in the scanned data. Identification of these landmarks has to resort to surface texture of the scanned object. Modifications to LASS were made to allow gray-scale images to be captured before or after the object was scanned. Two-dimensional gray-scale image must be mapped to the scanned data to acquire the 3D coordinates of a landmark. The method to map 2D images to the scanned data is based on the colinearity conditions and ray-tracing method. If the camera center and image coordinates are known, the corresponding object point must lie on a ray starting from the camera center and connecting to the image coordinate. By intersecting the ray with the scanned surface of the object, the 3D coordinates of a point can be solved. Experimentation has demonstrated the feasibility of the method.

  18. Development of routines for simultaneous in situ chemical composition and stable Si isotope ratio analysis by femtosecond laser ablation inductively coupled plasma mass spectrometry.

    PubMed

    Frick, Daniel A; Schuessler, Jan A; von Blanckenburg, Friedhelm

    2016-09-28

    Stable metal (e.g. Li, Mg, Ca, Fe, Cu, Zn, and Mo) and metalloid (B, Si, Ge) isotope ratio systems have emerged as geochemical tracers to fingerprint distinct physicochemical reactions. These systems are relevant to many Earth Science questions. The benefit of in situ microscale analysis using laser ablation (LA) over bulk sample analysis is to use the spatial context of different phases in the solid sample to disclose the processes that govern their chemical and isotopic compositions. However, there is a lack of in situ analytical routines to obtain a samples' stable isotope ratio together with its chemical composition. Here, we evaluate two novel analytical routines for the simultaneous determination of the chemical and Si stable isotope composition (δ(30)Si) on the micrometre scale in geological samples. In both routines, multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS) is combined with femtosecond-LA, where stable isotope ratios are corrected for mass bias using standard-sample-bracketing with matrix-independent calibration. The first method is based on laser ablation split stream (LASS), where the laser aerosol is split and introduced simultaneously into both the MC-ICP-MS and a quadrupole ICP-MS. The second method is based on optical emission spectroscopy using direct observation of the MC-ICP-MS plasma (LA-MC-ICP-MS|OES). Both methods are evaluated using international geological reference materials. Accurate and precise Si isotope ratios were obtained with an uncertainty typically better than 0.23‰, 2SD, δ(30)Si. With both methods major element concentrations (e.g., Na, Al, Si, Mg, Ca) can be simultaneously determined. However, LASS-ICP-MS is superior over LA-MC-ICP-MS|OES, which is limited by its lower sensitivity. Moreover, LASS-ICP-MS offers trace element analysis down to the μg g(-1)-range for more than 28 elements due to lower limits of detection, and with typical uncertainties better than 15%. For in situ simultaneous

  19. Silicon solar cell process development, fabrication, and analysis

    NASA Technical Reports Server (NTRS)

    Yoo, H. I.; Iles, P. A.; Leung, D. C.

    1981-01-01

    Work has progressed in fabrication and characterization of solar cells from ubiquitous crystallization process (UCP) wafers and LASS ribbons. Gettering tests applied to UCP wafers made little change on their performance compared with corresponding baseline data. Advanced processes such as shallow junction (SJ), back surface field (BSF), and multilayer antireflection (MLAR) were also applied. While BSF by Al paste had shunting problems, cells with SJ and BSF by evaporated Al, and MLAR did achieve 14.1% AMI on UCP silicon. The study of LASS material was very preliminary. Only a few cells with SJ, BSR, (no BSF) and MLAR were completed due to mechanical yield problems after lapping the material. Average efficiency was 10.7% AMI with 13.4% AMI for CZ controls. Relatively high minority carrier diffusion lengths were obtained. The lower than expected Jsc could be partially explained by low active area due to irregular sizes.

  20. Genetics Home Reference: Chanarin-Dorfman syndrome

    MedlinePlus

    ... abnormalities in the ichthyoses: inherited disorders of lipid metabolism. J Lipid Res. 2008 Apr;49(4):697-714. doi: 10.1194/jlr.R800002-JLR200. Epub 2008 Feb 2. Review. Citation on PubMed or Free article on PubMed Central Lass A, Zimmermann R, Haemmerle ...

  1. Evidence review for the 2016 International Ankle Consortium consensus statement on the prevalence, impact and long-term consequences of lateral ankle sprains.

    PubMed

    Gribble, Phillip A; Bleakley, Chris M; Caulfield, Brian M; Docherty, Carrie L; Fourchet, François; Fong, Daniel Tik-Pui; Hertel, Jay; Hiller, Claire E; Kaminski, Thomas W; McKeon, Patrick O; Refshauge, Kathryn M; Verhagen, Evert A; Vicenzino, Bill T; Wikstrom, Erik A; Delahunt, Eamonn

    2016-12-01

    Lateral ankle sprains (LASs) are the most prevalent musculoskeletal injury in physically active populations. They also have a high prevalence in the general population and pose a substantial healthcare burden. The recurrence rates of LASs are high, leading to a large percentage of patients with LAS developing chronic ankle instability. This chronicity is associated with decreased physical activity levels and quality of life and associates with increasing rates of post-traumatic ankle osteoarthritis, all of which generate financial costs that are larger than many have realised. The literature review that follows expands this paradigm and introduces emerging areas that should be prioritised for continued research, supporting a companion position statement paper that proposes recommendations for using this summary of information, and needs for specific future research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. The Effect of the Balance of Orthographic Neighborhood Distribution in Visual Word Recognition

    ERIC Educational Resources Information Center

    Robert, Christelle; Mathey, Stephanie; Zagar, Daniel

    2007-01-01

    The present study investigated whether the balance of neighborhood distribution (i.e., the way orthographic neighbors are spread across letter positions) influences visual word recognition. Three word conditions were compared. Word neighbors were either concentrated on one letter position (e.g.,nasse/basse-lasse-tasse-masse) or were unequally…

  3. Quantifying the timescales of Archean UHT metamorphism through U-Pb monazite and zircon petrochronology

    NASA Astrophysics Data System (ADS)

    Guevara, V.; MacLennan, S. A.; Schoene, B.; Dragovic, B.; Caddick, M. J.; Kylander-Clark, A. R.; Couëslan, C. G.

    2016-12-01

    Unraveling the timescales of metamorphism is crucial to understanding the mechanisms behind mass/heat transfer through Earth's crust. Though such mechanisms and their durations are becoming well constrained in modern (Phanerozoic) settings, the drivers of metamorphism in the ancient geologic record remain more enigmatic. The development of accessory phase petrochronology has allowed metamorphic evolution to be closely linked to isotopic dates, ultimately improving quantification of metamorphic durations. While in-situ petrochronological methods preserve textural and spatial context, they often lack the temporal resolution required to accurately quantify metamorphic duration in Archean terranes. Here we combine in-situ U-Pb monazite (mnz) and zircon (zrn) laser ablation split-stream (LASS) and high-precision ID-TIMS-TEA petrochronology of distinct grain domains to resolve the timescales of ultrahigh temperature (UHT) metamorphism in the Archean Pikwitonei granulite domain (PGD). The PGD encompasses >1.5x105 km2 of granulite-facies rocks on the NW edge of the Superior Province. Themodynamic modelling of a pelite from the western part of the PGD suggests peak P-T conditions of >8 kbar, 900-940 °C and UHT decompression to 8 kbar followed by cooling. LASS analysis of zrn inclusions in garnet (grt) yields a date of 2701 Ma, with Ti in zrn thermometry yielding T of 800-900 °C. LASS analysis of mnz yields dates of 2720-2680 Ma for low HREE domains with no to shallow negative Eu anomalies, suggestive of growth during plagioclase (plg) breakdown and grt stability. ID-TIMS analysis of a mnz fragment with a strong negative Eu anomaly, suggestive of growth during plg stability, gives a concordant 207Pb/206Pb date of 2666 Ma, consistent with LASS results of 2660-2640 Ma for chemically similar domains. ID-TIMS analyses of zrn rims yield a range of 207Pb/206Pb dates from 2671 to 2656 Ma (±<1 Ma). Ti in zrn yields 800 °C for these rims, indicating they grew at similar T

  4. Psychometric Properties of a Suicide Screen for Adjudicated Youth in Residential Care

    ERIC Educational Resources Information Center

    Langhinrichsen-Rohling, Jennifer; Hudson, Kenneth; Lamis, Dorian A.; Carr, Nicole

    2012-01-01

    There is a need to efficiently and effectively screen adjudicated youth residing within the juvenile justice system for suicide proneness. Accordingly, in the current study, the psychometric properties of the Life Attitude Schedule: Short Form (LAS:S), a 24-item risk assessment for suicide proneness, were assessed using data from adjudicated youth…

  5. Automation and Cataloging.

    ERIC Educational Resources Information Center

    Furuta, Kenneth; And Others

    1990-01-01

    These three articles address issues in library cataloging that are affected by automation: (1) the impact of automation and bibliographic utilities on professional catalogers; (2) the effect of the LASS microcomputer software on the cost of authority work in cataloging at the University of Arizona; and (3) online subject heading and classification…

  6. 78 FR 35047 - Notice of Application for Withdrawal and Opportunity for Public Meeting; Oregon

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... to contact either of the above individuals. The FIRS is available 24 hours a day, 7 days a week, to... regular business hours, 8 a.m. to 4 p.m., Monday through Friday, except Federal holidays. Before including... mine reclamation work completed at the White King/Lucky Lass Mine reclamation project area. This notice...

  7. DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.

    PubMed

    Zullo, Joseph M; Demarco, Ignacio A; Piqué-Regi, Roger; Gaffney, Daniel J; Epstein, Charles B; Spooner, Chauncey J; Luperchio, Teresa R; Bernstein, Bradley E; Pritchard, Jonathan K; Reddy, Karen L; Singh, Harinder

    2012-06-22

    A large fraction of the mammalian genome is organized into inactive chromosomal domains along the nuclear lamina. The mechanism by which these lamina associated domains (LADs) are established remains to be elucidated. Using genomic repositioning assays, we show that LADs, spanning the developmentally regulated IgH and Cyp3a loci contain discrete DNA regions that associate chromatin with the nuclear lamina and repress gene activity in fibroblasts. Lamina interaction is established during mitosis and likely involves the localized recruitment of Lamin B during late anaphase. Fine-scale mapping of LADs reveals numerous lamina-associating sequences (LASs), which are enriched for a GAGA motif. This repeated motif directs lamina association and is bound by the transcriptional repressor cKrox, in a complex with HDAC3 and Lap2β. Knockdown of cKrox or HDAC3 results in dissociation of LASs/LADs from the nuclear lamina. These results reveal a mechanism that couples nuclear compartmentalization of chromatin domains with the control of gene activity. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Baltimore Integrated Environmental Management Project ...

    EPA Pesticide Factsheets

    ... in so ...lr ï´ _.. "ll"* S ** ^53 .£ï* 5 . ïa-J 3 S ß*1-S 2^ß S SljJ i;5 t> fiji:* * = 1 * -3 a *:;; ´l´i| |||| Isil IIJI'I-- s^i". s^s^is ff^-881 =ï´-'-- 1-31 i S5K-S 3 " ´-5 l-aSS ...

  9. Correlation on Noisy Images

    DTIC Science & Technology

    1980-06-01

    lass,,., tassel eageeteg, assesses, sets,,e as isles lasgeges eegtal ages,,,, 5 iS gel it, seisteis 5 5,5 essla see, Sieges 5,5,55 Ill SIas ...jujNT iAALL STORE Nzv 2 SCALL FILTERINEDGE)CALL OPER(N,TEDGEi ,ALL P UTO bI (04 CALL POsUUT(4) 3 O CONTINUE END 49 APPENDIX B -Continued SUBROUTINE

  10. Open control/display system for a telerobotics work station

    NASA Technical Reports Server (NTRS)

    Keslowitz, Saul

    1987-01-01

    A working Advanced Space Cockpit was developed that integrated advanced control and display devices into a state-of-the-art multimicroprocessor hardware configuration, using window graphics and running under an object-oriented, multitasking real-time operating system environment. This Open Control/Display System supports the idea that the operator should be able to interactively monitor, select, control, and display information about many payloads aboard the Space Station using sets of I/O devices with a single, software-reconfigurable workstation. This is done while maintaining system consistency, yet the system is completely open to accept new additions and advances in hardware and software. The Advanced Space Cockpit, linked to Grumman's Hybrid Computing Facility and Large Amplitude Space Simulator (LASS), was used to test the Open Control/Display System via full-scale simulation of the following tasks: telerobotic truss assembly, RCS and thermal bus servicing, CMG changeout, RMS constrained motion and space constructible radiator assembly, HPA coordinated control, and OMV docking and tumbling satellite retrieval. The proposed man-machine interface standard discussed has evolved through many iterations of the tasks, and is based on feedback from NASA and Air Force personnel who performed those tasks in the LASS.

  11. 1952 midsummer fuel moistures in Oregon and Washington national forests compared with other years.

    Treesearch

    Owen P. Cramer

    1953-01-01

    The inflammability of Oregon and Washington national forests during the middle of the 1952 fire season was slightly lass than the 12-year record high set in 1951 (table 1). The rating is based on the 25 lowest daily observations of fuel-moisture indicator sticks in the July 16 to August 21 period. Stick readings from 64 key fire-danger stations near the exterior...

  12. NRL SSD Research Achievements: 19701980. Volume 2

    DTIC Science & Technology

    2015-10-30

    Astronomy Observatory (HEAO-1) was launched, which carried the very large NRL SSD Large Area Sky Survey (LASS) experiment (HEAO-1 A1). These X-ray...overview of this research. High energy space environment research was fundamentally advanced in the 1970’s. The first High Energy Astronomy ...larger than any previously flown X-ray astronomy spacecraft, and the X-ray detectors provided the most comprehensive X-ray catalogue of astrophysical

  13. JPRS Report, West Europe.

    DTIC Science & Technology

    1987-07-31

    Sees Earlier Elections 24 Setback for Privitization Movement, by Egon Balsby 25 Many Economic Problems Unsolved, by Lasse Ellegaard 28 First...Geisler, Inuit Ataqatigiit. Setback For Privitization Movement Copenhagen BERLINGSKE AFTEN in Danish 29 May - 4 Jun 87 pp lr 2 [Article by Egon Balsby...34Yes to Socialism — No to Privitization "! [Text] The two large parties in Greenland politics, Ätassut and Siumut, both suffered defeats in an

  14. Development of a Distributed Source Containment Transport, Transformation, and Fate (CTT&F) Sub-Model for Military Installations

    DTIC Science & Technology

    2007-08-01

    includes soil erodibility terms from the Universal Soil Lass Equation ( USLE ) for estimating the overland sediment transport capacity (for both the x and y...q = unit flow rate of water = va h [L2/T] vc = critical velocity for erosion overland [L/T] K = USLE soil erodibility factor C = USLE soil ...cover factor P = USLE soil management practice factor Be = width of eroding surface in flow direction [L]. In channels, sediment particles can be

  15. The Army Study Program Fiscal Year 1988 Report

    DTIC Science & Technology

    1988-03-24

    Studies Institute (ATTN: AWCI) 4 Defense Nuclear Agency (ATTN: LASS) 1 Engineering Studies Center (ATTN: ESC) 5 Commandant: US Army War College (ATTN...Library) 5 US Navy War College (ATTN: Library) 5 US Air War College (ATTN: Library) 5 Chief of Naval Operations (ATTN: 0P916) 5 Headquarters, US Air... war . Agreement is needed on the key words describing Army functional areas and related terms and on the relationships among them and other factors

  16. Radiation Hardness of Efratom M-100 Rubidium Frequency Standard

    DTIC Science & Technology

    1982-12-01

    h i ghes t f l uence o f 6.15 x 1012n/crn2 t h e norma l i zed ac pho tocur ren ts were about 702 o f t he normal ized dc photo- c u r r...100, FRK, M-1000. Pyrex ( t r ade name of Corning Glass) . e Cells produced i n Munich use Schott Duran 50 g lass which i s nearly ident ica l

  17. Bond Strength of Composite to Dentin using Resin-Modified Glass Ionomers as Bonding Agents

    DTIC Science & Technology

    2016-03-02

    59 MDW/SGVU SUBJECT: Professional Presentation Approval 2 MAR 20 16 l. Your paper, entitl ed Bond Strength of Composite to Dentin using Resin...Modified G lass Ionomers as Bonding Agents presented at Journal of Dental Research with MDWI 41- 108, and has been assigned local fi le #16086. 2...Vandewalle /Civ/SGDTG (59th CSPG/SGVU) DECS I 5-009 PROTOCOL TITLE Bond Strength of Composite to Dentin using Resin-modified Glass lonomers as

  18. Large Advanced Space Systems (LASS) computer-aided design program additions

    NASA Technical Reports Server (NTRS)

    Farrell, C. E.

    1982-01-01

    The LSS preliminary and conceptual design requires extensive iteractive analysis because of the effects of structural, thermal, and control intercoupling. A computer aided design program that will permit integrating and interfacing of required large space system (LSS) analyses is discussed. The primary objective of this program is the implementation of modeling techniques and analysis algorithms that permit interactive design and tradeoff studies of LSS concepts. Eight software modules were added to the program. The existing rigid body controls module was modified to include solar pressure effects. The new model generator modules and appendage synthesizer module are integrated (interfaced) to permit interactive definition and generation of LSS concepts. The mass properties module permits interactive specification of discrete masses and their locations. The other modules permit interactive analysis of orbital transfer requirements, antenna primary beam n, and attitude control requirements.

  19. Advanced space system analysis software. Technical, user, and programmer guide

    NASA Technical Reports Server (NTRS)

    Farrell, C. E.; Zimbelman, H. F.

    1981-01-01

    The LASS computer program provides a tool for interactive preliminary and conceptual design of LSS. Eight program modules were developed, including four automated model geometry generators, an associated mass properties module, an appendage synthesizer module, an rf analysis module, and an orbital transfer analysis module. The existing rigid body controls analysis module was modified to permit analysis of effects of solar pressure on orbital performance. A description of each module, user instructions, and programmer information are included.

  20. Depth and Motion Prediction for Earth Penetrators

    DTIC Science & Technology

    1978-06-01

    multiple-layer targets. For targets with accurately knowni properties , the final-depth results are accurate ihný pret AM all13 EIIW FINVS S WLT n.- U lass S...Project hAl611o2AT2?, Task A2, Work Unit󈧊, " Effectiveness of Earth Penetrators in Various Geologic Environments." Mr. R. S. Bernard conducted the... effects in the selective destruction of localized targets (airfields, factories, utilities, etc.). The effectiveness of these weapons, however, is

  1. European Science Notes. Volume 40, Number 9

    DTIC Science & Technology

    1986-09-01

    15 invited speakers pre- oxygen ases s asaon dioxide and senting talks on various topics in the oxygen as well as ammonia, chlorine, hy-ara fbisnsr...tantalum oxides (H+), work involves the contributions of elec- special lasses (H+, Na+, K+), valinomy- trical engineers as well as chemists. cin (K), tetra...copy only devise circuitry but work on concep- may be obtained from me]) he derived a tual design as well . Incidentally, the theorem that gives the

  2. Microcircuit Device Reliability Digital Detailed Data

    DTIC Science & Technology

    1976-01-01

    TYPE s No. FUNCTION A LASS PINS TEMP. TYPE CLASS LEVEL I eFAILED 8 NO. CHIP TEST APPL. TEST PAR1 t T AGATES PROTECT. DATE E:V. D TYPE HOURST :708 FLIP...LEVEL # EFAILED s a NO. t CHIP i TEST 3 APPL. a TEST I PAR! 3 a GATES s PROTECT. a DATE 3 ENV. t TYPE I 3 -OUHb s 354H0( 3 GATE C-I CDIP 14 150C :11.A

  3. Evaluation of Military Field-Water Quality. Volume 7. Performance Evaluation of the 600-GPH Reverse Osmosis Water Purification Unit (ROWPU): reverse Osmosis (RO) Components

    DTIC Science & Technology

    1986-02-01

    Data-for ASsessingHealthRISKS In Potential Theaters ~ of Operation forU,5. Mil-itary._orces. Jf-jr cLAss t:cAToN 9; r-.$ ’AGg UNCLASSIFIED Volume 7...Bypass, Potable-Water Disinfection,_ and Water-Quality Analysis Techniques; and Vol. 9, Data for Assessing Health Risks in Potential Theaters of Operation ...cleaning the RO elements, with objectives of improving solute rejection and reducing operating pressure. The most common method is to flush citric acid

  4. Inertial Survey Application to Civil Works,

    DTIC Science & Technology

    1983-01-01

    closer together the ZUPTS must be performed. ZUPTS are used by the system to provide external information to the error control system used (Kalman...the best estimate of the system states. Accuracy of the system is increased when the sensor information from the inertial platform is compared with the...building a new version of its Auto-Surveyor System to be known as LASS II. This version will be based on the production model of the PADS presently

  5. Digital Screening and Halftone Techniques for Raster Processing,

    DTIC Science & Technology

    1980-01-14

    I 7 A)-AO81 090 ARMY ENGINEER TOPOGRAPH4IC LASS FORT Bs.voiR VA 161/ OIGITAL SCREENING ANO HALFTONE TECNNIOUIES FOR RASTER PROCLPSINM-.TC(U) JAN GO R... HALFTONE TECHNIQUES 0FOR RASTER PROCESSING BY RICHARD L. ROSENTHAL DTIC FEB 𔃼 7 1980 W.A Approved for public release; distribution unlimited AU...creening and halftone techniques forlt -rastei’ processing ~ A 6. PERFORMING ORG. REPORT NUMBER 7. AUTNOP-r- S. CONTRACT OR GRANT NUMBER(*) c*t- Ri chard

  6. Chemical Durability Improvement and Static Fatigue of Glasses.

    DTIC Science & Technology

    1982-08-01

    Afl-Alla 837 RENSSELAER POLYIECmfJ!C INST TRtOY NY DEPT OF MATERIAL--ETC F/6 ii/ CHEMICAL DURABILITY IMPROVEMENT AND STATIC FATIGUE OF GLASSESW AUC2...82 M TOMOZAWA NOGGIN 7A-C-0315 UNC LASS IF IED N ENEEEEEE FINAL TECHNICAL REPORT For the period April 1, 1978 "u March 31, 198200 CHEMICAL DURABILITY...REPORT A PERIOD COVERED Chemical Durability Improvement and Static Final Technical Report Fatiue o GlasesApril 1, 1978"’,March 31, 1982 S. PERFORMING ORG

  7. Optical Computing Research.

    DTIC Science & Technology

    1987-10-30

    1489-1496, 1985. 13. W.T. Welford and R. Winston , The Optics of Nonimaging Concentrators , Academic Press, New York, N.Y., 1978 (see Appendix A). 14. R.H...34, Applied Optics , Vol. 25, pp. 3033-3046 (1986). 2. P. Idell and J.W. Goodman, "Design of optical imaging concentrators for partially coherent light: absolute...AD-fIB? Ŗ OPTICAL CONPIITINO RESEAIRCII(U STANFORD UlNIV CA STINFORD / ELECTRONICS LASS J N 0000W4 30 OCT 97 SMAFOSR-TR-S?-1635 RFOSR-96

  8. Quantum 1/f Noise in High Technology Applications Including Ultrasmall Structures and Devices

    DTIC Science & Technology

    1991-07-15

    chaos nature of 1/f noise in infrared detectors . 20. 0ISTRIBUTCN/AVAJLABi3LITY OF ABSTRACT j21. Ai3STR.ACT SECURITY fLASS.FiCATION (ZUN.’CASSIF!ED...of 1/f noise in infrared detectors . Approved .or .UnjtlC relSS* distribution unlimited AIR FrnPc COF SCIEMTIFIC RESEARCR (knSC) NOTICE OF T1SITTAL...in ultrasmall BJT’s was found to agree reasonably with the experiment. Finally, the fractional dimension of band- limited quantum 1/f noise was deter

  9. Cost Effectiveness Analysis, A DTIC Bibliography.

    DTIC Science & Technology

    1980-07-01

    CoSt.Nonstetionary Case. - AD-AO46 808 AD-AO0O 505 -PERSONAL AUTHOR -IKDEX-49 UNCLASSIFIED ZOW)? SAV-C"U F UNC LASS IF! ED *SCHUMACHER. WILLIAM J. OSEABERO. ERNEST ...Laboratory. Wright- Patterson AFB. envirOnmelnks wnder risk. Historically- VERT hs Ohio 45433. This work was ai calibration and been used crirnCiPally to...WRIGHT- PATTERSON AFB OH SCHOOL OF ALEXANDRIA VA SYSTEMS A𔃾D LOGISTICS A Methodology and Analysis for Cost-EffzCtive An Investigation of Changes in

  10. Opportunities in Air Force Research and Development: Three Regional Workshop

    DTIC Science & Technology

    1982-08-01

    BAFB DC 20332-6448 F49620-81-C-0049 J1. SUPPLEMENTARY NOTES 12a. DISTRUITION/iAVAILABLUTY STATEMENT t2A. OISTWILUTION CODE d ~ztr:L . oeasgJ 13. A1STUACT...Mewmwflm 200 waV* J ) conduct, on a regional basis, a series of three one day workshops, convening 300- 400 minority scientists from 19 states, 77...OF ABSTRACT OF REPORT OF THIS PAGE j OF ABSTRACT unc lass ified I unclass ified __ NSN 7540-01-2SSOO Stanaro Form 2" (890104 Draft) ft5VW " A" VidMS89

  11. The Army’s Activities in Artificial Intelligence/Robotics,

    DTIC Science & Technology

    1982-08-27

    r7 AD-,30 128 THE ARMY S ACT"IVITES AN ARTIFICIAL INTELLGENCE/ROBOT CS U) ARMY ENGINEER TOPOGRAPHIC LASS FORT RELVOIR VA R D LEIGHT 27 AUG 82 ETL-042...necessary for autonomous battlefield systems in the 1990’ s . The potential applications of AI/R systems to Army needs (’ appear to be limitless. DARCOM and...procurement. The contract statement or work had four tasks to be performed. They were: a. From Army concepts and doctrine for the 1990’ s and beyond, such as

  12. Waterfront Damage Repair for Amphibious and Advanced Bases.

    DTIC Science & Technology

    1988-01-01

    W -. In-h E E . EE ,. E-.. fto LI *w .- o A’., WIW~~~~~ ~ V11-11 WI 1 MI - t~ r LUnc lass if ied SECUR .’ - ASSIFICATION OF T.15 PAGE Wh n I- II...JlI.h-I 1 5 SECURITYS CL ASS ’of Ih,0 Il Naval Facilities Engineering Command Unclassified 200 Stovall Street Unclassfied ___ 5 DECLASS-7C AT70N... tangling of tether cord. 4. Must have trained crew to operate. ’ SCANNING SONAR To increase the efficiency of an underwater damage assessment survey

  13. Systems design and analysis of the microwave radiometer spacecraft

    NASA Technical Reports Server (NTRS)

    Garrett, L. B.

    1981-01-01

    Systems design and analysis data were generated for microwave radiometer spacecraft concept using the Large Advanced Space Systems (LASS) computer aided design and analysis program. Parametric analyses were conducted for perturbations off the nominal-orbital-altitude/antenna-reflector-size and for control/propulsion system options. Optimized spacecraft mass, structural element design, and on-orbit loading data are presented. Propulsion and rigid-body control systems sensitivities to current and advanced technology are established. Spacecraft-induced and environmental effects on antenna performance (surface accuracy, defocus, and boresight off-set) are quantified and structured material frequencies and modal shapes are defined.

  14. Simulating Rule-Based Systems

    DTIC Science & Technology

    1988-12-01

    the number of facts. NFIRE : location of the rule status flag. NLVL: the number of levels. NRULE: the number of rules. 116 NRUN: the number of runs. PD...C-INITIALIZE THE RULE MATRIX 124 C NFIRE -4 +MAXL+MAXR NFAC-0 IL-MAXL-MINL+l IR-MAXR-MINR+ 1 DO 10 I-1,NRULE MR(I,1)=I NR( I, 2)-MINL+INT(RAN( II) *IL...NR( I, 3)-MINR+INT(RAN(II)*IR) NR( I, NFIRE )-0 10 CONTINUE-A C C-STORE THE RANDOM-ASSERTION SET IN A MATRIX C READ(8,* )NRUN, lASS DO 120 I-1,NRTJN

  15. Finding of No Significant Impact: Construction, Operation, and Maintenance of a Solar Array United States Air Force Academy, Colorado

    DTIC Science & Technology

    2010-04-21

    2006·EX·L, Leather , Nice! 26k mi $17,977 #B21244A 1~-8556 ACCORD EX 11)01· V6, Auto,lthr, Moon Roof. #6302A $6,988 HEUBERGER MOTORS 475-1920...ns’~fl8~\\!Tv DODGE FIT 2009·Sport Pkg, Auto, Loaded #101399A $15,988 HEUIIEIIGER MOTORS 475-1920 Hyundai • Cars SONATALTD2008· Auto, Leather ...37Sol C <:LASS 󈧌-Every Op· bon, NAV, Black/ Tan . $27,999 #G343 WHY PAY R!TAIU SMART CHOICE AUTO 641·37Sol E3502006 $31),995 #U678 Red

  16. Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.

    PubMed

    Frangioudakis, G; Garrard, J; Raddatz, K; Nadler, J L; Mitchell, T W; Schmitz-Peiffer, C

    2010-09-01

    Lipid-induced insulin resistance is associated with intracellular accumulation of inhibitory intermediates depending on the prevalent fatty acid (FA) species. In cultured myotubes, ceramide and phosphatidic acid (PA) mediate the effects of the saturated FA palmitate and the unsaturated FA linoleate, respectively. We hypothesized that myriocin (MYR), an inhibitor of de novo ceramide synthesis, would protect against glucose intolerance in saturated fat-fed mice, while lisofylline (LSF), a functional inhibitor of PA synthesis, would protect unsaturated fat-fed mice. Mice were fed diets enriched in saturated fat, n-6 polyunsaturated fat, or chow for 6 wk. Saline, LSF (25 mg/kg x d), or MYR (0.3 mg/kg x d) were administered by mini-pumps in the final 4 wk. Glucose homeostasis was examined by glucose tolerance test. Muscle ceramide and PA were analyzed by mass spectrometry. Expression of LASS isoforms (ceramide synthases) was evaluated by immunoblotting. Both saturated and polyunsaturated fat diets increased muscle ceramide and induced glucose intolerance. MYR and LSF reduced ceramide levels in saturated and unsaturated fat-fed mice. Both inhibitors also improved glucose tolerance in unsaturated fat-fed mice, but only LSF was effective in saturated fat-fed mice. The discrepancy between ceramide and glucose tolerance suggests these improvements may not be related directly to changes in muscle ceramide and may involve other insulin-responsive tissues. Changes in the expression of LASS1 were, however, inversely correlated with alterations in glucose tolerance. The demonstration that LSF can ameliorate glucose intolerance in vivo independent of the dietary FA type indicates it may be a novel intervention for the treatment of insulin resistance.

  17. Using the magmatic record to constrain the growth of continental crust-The Eoarchean zircon Hf record of Greenland

    NASA Astrophysics Data System (ADS)

    Fisher, Christopher M.; Vervoort, Jeffrey D.

    2018-04-01

    Southern West Greenland contains some of the best-studied and best-preserved magmatic Eoarchean rocks on Earth, and these provide an excellent vantage point from which to view long-standing questions regarding the growth of the earliest continental crust. In order to address the questions surrounding early crustal growth and complementary mantle depletion, we present Laser Ablation Split Stream (LASS) analyses of the U-Pb and Hf isotope compositions of zircon from eleven samples of the least-altered meta-igneous rocks from the Itsaq (Amîtsoq) Gneisses of the Isukasia and Nuuk regions of southern West Greenland. This analytical technique allows a less ambiguous approach to determining the age and Hf isotope composition of complicated zircon. Results corroborate previous findings that Eoarchean zircon from the Itsaq Gneiss (∼3.85 Ga to ∼3.63 Ga) were derived from a broadly chondritic source. In contrast to the Sm-Nd whole rock isotope record for southern West Greenland, the zircon Lu-Hf isotope record provides no evidence for early mantle depletion, nor does it suggest the presence of crust older than ∼3.85 Ga in Greenland. Utilizing LASS U-Pb and Hf data from the Greenland zircons studied here, we demonstrate the importance of focusing on the magmatic (rather than detrital) zircon record to more confidently understand early crustal growth and mantle depletion. We compare the Greenland Hf isotope data with other Eoarchean magmatic complexes such as the Acasta Gneiss Complex, Nuvvuagittuq greenstone belt, and the gneissic complexes of southern Africa, and all lack zircons with suprachondritic Hf isotope compositions. In total, these data suggest only a very modest volume of crust was produced during (or survived from) the Hadean and earliest Eoarchean. There remains no record of planet-scale early Earth mantle depletion in the Hf isotope record prior to 3.8 Ga.

  18. Duration of convergence at the Pacific-Gondwana plate margin: insights from accessory phase petrochronology of the Alpine Schist, New Zealand

    NASA Astrophysics Data System (ADS)

    Briggs, S. I.; Cottle, J. M.; Smit, M. A.; Arnush, N. F.

    2016-12-01

    The timing, duration and along-strike synchroneity of metamorphism and anataxis in the Alpine Schist of New Zealand is a matter of considerable debate. Our preliminary data indicate that metamorphism resulting in garnet growth occurred from 97 - 75 Ma, and anatectic melting occurred from 80 - 51 Ma. These events are contemporaneous with rifting of Zealandia from East Gondwana, and Tasman Sea spreading from 83 - 52 Ma. An important implication of these results is that Late Cretaceous convergence along the Zealandia segment of the Pacific-Gondwana plate margin may have persisted much later than previously thought, and that convergence and extension occurred coevally in adjacent areas. This poses the question: for how long did convergence continue along the Pacific-Gondwana plate margin during East Gondwana breakup? To fully decipher the multiple stages of the complex metamorphic history recorded in the Alpine Schist, we combine Lu-Hf garnet geochronology with U-Th/Pb and REE analyses of zircon and monazite. We use the newly developed `single-shot laser ablation split stream' (SS-LASS) analysis method to obtain depth profiles through 5-10 µm metamorphic zircon overgrowths at 100 nm depth resolution to constrain both the timing and petrological context of discrete metamorphic zircon (re-)crystallization events recorded in the Alpine Schist. We also employ high spatial resolution LASS analysis to target rare 5 - 20 µm monazite in thin section to augment garnet and zircon data. Our multi-accessory phase petrochronology approach is capable of resolving discrete short-duration thermal events, strengthening the geological interpretation of `mean' Lu-Hf garnet ages and discerning between an episodic versus a prolonged history of metamorphism. In addition, comparison with geochronology from anatectic pegmatites clarifies the temporal relationship between metamorphism and melting in the Alpine Schist, while providing direct constraints on the timing and duration of

  19. Highlights of L011.

    DTIC Science & Technology

    1977-08-03

    AD—A OQ 15 CALIFORNIA UN I V SANTA CRUZ INFORMATION SCIENCES FIG 9.’2 HIGHLIGHTS OF LO11.(U) ~~~ LASS ~~~~~ TR— 77—8—OO5 H MCKEEMAN EN D...EA & WORK UNIT NUMBERS Board of Studies in Information Sciences - . University of Californiav ~~~~~~~~ • I Santa Cruz, Ca1ifnrn(~ 9S~ f LL - II. C O...Office of Naval Research contract NOOO1~ —76 C O682.* .~~~~ .. 3. The Board of Studies in InforMation Sciences, UCSCe~~~~ ~~~~~ 00 ~~ ~~~~~ ifl ,’jIIfl

  20. Energy Transfer between Post-Transition Elements & Rare Earths in Oxide & Chalcogenide Glasses.

    DTIC Science & Technology

    1979-08-27

    Caird [13]. A calculation of reduced matrix elements of Pr3 in 20 Na O • 80 TeO2 glass [14] showed that they differ slightly from data of ref. [121... glasses Transition (lass 35 ZnO 65 TeO2 20 Na2 O 80 TeO 2 fX 106 fX 106 l.,eas 3a, a) Ia’l. faI f.me.s f al f+ I fal 3 H4 - 3 H6 1.56 1.65 1.12...Rare-Earth Doped Glasses 20. jIST HAEV CCnFn~m ,i cn,on ra e sideit If c."*Ar’ -- ~ 14-r by t?-h.c .: r Intensity parameters, radiative transition

  1. Integrated Fiber-Optic Coupler.

    DTIC Science & Technology

    1987-04-01

    p. 563, 1984. 1 .T.H. W. n h= n , G.M. Metze, B.- Y . Tuu ,J.C.C. Far., "A a s double-heterostructure diode lasers fabricated on a monolithic GaAs/Si...INII RAitI) R HR ( OLIlIR HR t( N ,% NOS( I D108 I R IOst\\1 tN( LASS~l1 D R 87 mm mhhh z V. 0 0- z C ,, Technical Document 1086 April 1987 Integrated...Cmeed".~) n Interated Fiber-Optic Coupler 12 PERSONAL AU1HOS) P.L Pruaal, E.R. Foesuim 139 TYPE OF RE[POR 3b, IME COVERED4 DATE OF REPORT (’r. 4#e ow S

  2. Soc Trang City Apt., Vietnam. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

    DTIC Science & Technology

    1971-03-25

    FROM HOURLY OBSERVATIONS) 40001 .SC TRANG VIETNAM/CITY AIRPORT 57,59j6. ,70 HARSTATION STATION ANe ytafts NONIN C ALL WEATHER O300-0500| C LA~SS...90 9,1 ow690 9590 989089o,00OO,0OO, > 200 1 8906 9501 905 98o3 98#6 190t 9/905 9905 99,8! $90 99. 00 00 00,0o0090 00 6.oI 906 950]’ 9605_98910 986...7 9 8 00006 _> 400 9293 9590 9697 91.4 98,4 99.4 99,4 994 99.7 99.7 99.7 99. 99. 00.000.0 2300 �’ "@%1 -W, 11f917 ŝ 4f7 9994 990 9WI 99# 998 999

  3. Geochronology of Zircon in Eclogite Reveals Imbrication of the Ultrahigh-Pressure Western Gneiss Region of Norway.

    NASA Astrophysics Data System (ADS)

    Young, D. J.; Kylander-Clark, A. R.; Root, D. B.

    2014-12-01

    Eclogite provides the only record of kinematic events at the deepest levels of orogens. Integrating the U-Pb geochronology and trace element chemistry of zircon in eclogite reveals the most complete view of the PTt history, yet low concentrations of uranium and zirconium and drier compositions that hinder zircon growth at peak conditions render it a challenging rocktype for this approach. The iconic Western Gneiss Region (WGR) in Norway is one of the largest terranes of deeply subducted continental rocks in the world, and contains many indicators of ultrahigh-pressure metamorphic conditions (P>2.8 GPa) that developed during the Siluro-Devonian Caledonian Orogeny. A metamorphic transition from amphibolite-facies to ultrahigh-pressure eclogite facies broadly coincides with a km-scale shear zone that underlies the majority of the WGR. A critical unknown is the timing of movement on this feature, which emplaced allochthonous units above the Baltica basement, but might also have accommodated late-orogenic exhumation of the WGR from mantle depths. We carried out laser ablation split-stream ICPMS (LASS) and selected multigrain TIMS analyses of zircons from eleven eclogites across the southern WGR, of which eight are located within or above the shear zone. LASS spots on polished grains mostly yield weakly discordant Proterozoic intrusive ages, and often minimal indication of a Caledonian (U)HP metamorphic overprint. Direct ablation into unpolished zircon reveals thin rims of Caledonian age in some cases. Overall, the dataset shows that all samples began zircon growth at approximately the same time (ca. 430-420 Ma). Eclogite from lower levels of the shear zone does not contain any dates younger than ca. 410 Ma, however, while eclogite from higher levels continued growth until ca. 400 Ma. We interpret this to result from thrusting of the WGR above cooler basement after 410 Ma, terminating new zircon crystallization within the shear zone but allowing limited further growth in

  4. The Hall D solenoid helium refrigeration system at JLab

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Laverdure, Nathaniel A.; Creel, Jonathan D.; Dixon, Kelly d.

    Hall D, the new Jefferson Lab experimental facility built for the 12GeV upgrade, features a LASS 1.85 m bore solenoid magnet supported by a 4.5 K helium refrigerator system. This system consists of a CTI 2800 4.5 K refrigerator cold box, three 150 hp screw compressors, helium gas management and storage, and liquid helium and nitrogen storage for stand-alone operation. The magnet interfaces with the cryo refrigeration system through an LN2-shielded distribution box and transfer line system, both designed and fabricated by JLab. The distribution box uses a thermo siphon design to respectively cool four magnet coils and shields withmore » liquid helium and nitrogen. We describe the salient design features of the cryo system and discuss our recent commissioning experience.« less

  5. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

    PubMed

    Demirkan, Ayşe; van Duijn, Cornelia M; Ugocsai, Peter; Isaacs, Aaron; Pramstaller, Peter P; Liebisch, Gerhard; Wilson, James F; Johansson, Åsa; Rudan, Igor; Aulchenko, Yurii S; Kirichenko, Anatoly V; Janssens, A Cecile J W; Jansen, Ritsert C; Gnewuch, Carsten; Domingues, Francisco S; Pattaro, Cristian; Wild, Sarah H; Jonasson, Inger; Polasek, Ozren; Zorkoltseva, Irina V; Hofman, Albert; Karssen, Lennart C; Struchalin, Maksim; Floyd, James; Igl, Wilmar; Biloglav, Zrinka; Broer, Linda; Pfeufer, Arne; Pichler, Irene; Campbell, Susan; Zaboli, Ghazal; Kolcic, Ivana; Rivadeneira, Fernando; Huffman, Jennifer; Hastie, Nicholas D; Uitterlinden, Andre; Franke, Lude; Franklin, Christopher S; Vitart, Veronique; Nelson, Christopher P; Preuss, Michael; Bis, Joshua C; O'Donnell, Christopher J; Franceschini, Nora; Witteman, Jacqueline C M; Axenovich, Tatiana; Oostra, Ben A; Meitinger, Thomas; Hicks, Andrew A; Hayward, Caroline; Wright, Alan F; Gyllensten, Ulf; Campbell, Harry; Schmitz, Gerd

    2012-01-01

    Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57 phosphatidylcholines (PC), 20 lysophosphatidylcholines (LPC), 27 phosphatidylethanolamines (PE), and 16 PE-based plasmalogens (PLPE), as well as their proportions in each major class. This effort yielded 25 genome-wide significant loci for phospholipids (smallest P-value = 9.88×10(-204)) and 10 loci for sphingolipids (smallest P-value = 3.10×10(-57)). After a correction for multiple comparisons (P-value<2.2×10(-9)), we observed four novel loci significantly associated with phospholipids (PAQR9, AGPAT1, PKD2L1, PDXDC1) and two with sphingolipids (PLD2 and APOE) explaining up to 3.1% of the variance. Further analysis of the top findings with respect to within class molar proportions uncovered three additional loci for phospholipids (PNLIPRP2, PCDH20, and ABDH3) suggesting their involvement in either fatty acid elongation/saturation processes or fatty acid specific turnover mechanisms. Among those, 14 loci (KCNH7, AGPAT1, PNLIPRP2, SYT9, FADS1-2-3, DLG2, APOA1, ELOVL2, CDK17, LIPC, PDXDC1, PLD2, LASS4, and APOE) mapped into the glycerophospholipid and 12 loci (ILKAP, ITGA9, AGPAT1, FADS1-2-3, APOA1, PCDH20, LIPC, PDXDC1, SGPP1, APOE, LASS4, and PLD2) to the sphingolipid pathways. In large meta-analyses, associations between FADS1-2-3 and carotid intima media thickness, AGPAT1 and type 2 diabetes, and APOA1 and coronary artery disease were observed. In conclusion, our

  6. MSFC Three Point Docking Mechanism design review

    NASA Technical Reports Server (NTRS)

    Schaefer, Otto; Ambrosio, Anthony

    1992-01-01

    In the next few decades, we will be launching expensive satellites and space platforms that will require recovery for economic reasons, because of initial malfunction, servicing, repairs, or out of a concern for post lifetime debris removal. The planned availability of a Three Point Docking Mechanism (TPDM) is a positive step towards an operational satellite retrieval infrastructure. This study effort supports NASA/MSFC engineering work in developing an automated docking capability. The work was performed by the Grumman Space & Electronics Group as a concept evaluation/test for the Tumbling Satellite Retrieval Kit. Simulation of a TPDM capture was performed in Grumman's Large Amplitude Space Simulator (LASS) using mockups of both parts (the mechanism and payload). Similar TPDM simulation activities and more extensive hardware testing was performed at NASA/MSFC in the Flight Robotics Laboratory and Space Station/Space Operations Mechanism Test Bed (6-DOF Facility).

  7. Craniofacial bone abnormalities and malocclusion in individuals with sickle cell anemia: a critical review of the literature

    PubMed Central

    Costa, Cyrene Piazera Silva; de Carvalho, Halinna Larissa Cruz Correia; Thomaz, Erika Bárbara Abreu Fonseca; Sousa, Soraia de Fátima Carvalho

    2012-01-01

    This study aims to critically review the literature in respect to craniofacial bone abnormalities and malocclusion in sickle cell anemia individuals. The Bireme and Pubmed electronic databases were searched using the following keywords: malocclusion, maxillofacial abnormalities, and Angle Class I, Class II and lass III malocclusions combined with sickle cell anemia. The search was limited to publications in English, Spanish or Portuguese with review articles and clinical cases being excluded from this study. Ten scientific publications were identified, of which three were not included as they were review articles. There was a consistent observation of orthodontic and orthopedic variations associated with sickle cell anemia, especially maxillary protrusions. However, convenience sampling, sometimes without any control group, and the lack of estimates of association and hypotheses testing undermined the possibility of causal inferences. It was concluded that despite the high frequency of craniofacial bone abnormalities and malocclusion among patients with sickle cell anemia, there is insufficient scientific proof that this disease causes malocclusion PMID:23049386

  8. Multiple New Loci Associated with Kidney Function and Chronic Kidney Disease: The CKDGen consortium

    PubMed Central

    Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A.; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L.; Parsa, Afshin; Gao, Xiaoyi; Yang, Qiong; Smith, Albert V.; O’Connell, Jeffrey R.; Li, Man; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Hwang, Shih-Jen; Johnson, Andrew D.; Dehghan, Abbas; Teumer, Alexander; Paré, Guillaume; Atkinson, Elizabeth J.; Zeller, Tanja; Lohman, Kurt; Cornelis, Marilyn C.; Probst-Hensch, Nicole M.; Kronenberg, Florian; Tönjes, Anke; Hayward, Caroline; Aspelund, Thor; Eiriksdottir, Gudny; Launer, Lenore; Harris, Tamara B.; Rapmersaud, Evadnie; Mitchell, Braxton D.; Boerwinkle, Eric; Struchalin, Maksim; Cavalieri, Margherita; Singleton, Andrew; Giallauria, Francesco; Metter, Jeffery; de Boer, Ian; Haritunians, Talin; Lumley, Thomas; Siscovick, David; Psaty, Bruce M.; Zillikens, M. Carola; Oostra, Ben A.; Feitosa, Mary; Province, Michael; Levy, Daniel; de Andrade, Mariza; Turner, Stephen T.; Schillert, Arne; Ziegler, Andreas; Wild, Philipp S.; Schnabel, Renate B.; Wilde, Sandra; Muenzel, Thomas F.; Leak, Tennille S; Illig, Thomas; Klopp, Norman; Meisinger, Christa; Wichmann, H.-Erich; Koenig, Wolfgang; Zgaga, Lina; Zemunik, Tatijana; Kolcic, Ivana; Minelli, Cosetta; Hu, Frank B.; Johansson, Åsa; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H; Wright, Alan F; Campbell, Harry; Ellinghaus, David; Schreiber, Stefan; Aulchenko, Yurii S; Rivadeneira, Fernando; Uitterlinden, Andre G; Hofman, Albert; Imboden, Medea; Nitsch, Dorothea; Brandstätter, Anita; Kollerits, Barbara; Kedenko, Lyudmyla; Mägi, Reedik; Stumvoll, Michael; Kovacs, Peter; Boban, Mladen; Campbell, Susan; Endlich, Karlhans; Völzke, Henry; Kroemer, Heyo K.; Nauck, Matthias; Völker, Uwe; Polasek, Ozren; Vitart, Veronique; Badola, Sunita; Parker, Alexander N.; Ridker, Paul M.; Kardia, Sharon L. R.; Blankenberg, Stefan; Liu, Yongmei; Curhan, Gary C.; Franke, Andre; Rochat, Thierry; Paulweber, Bernhard; Prokopenko, Inga; Wang, Wei; Gudnason, Vilmundur; Shuldiner, Alan R.; Coresh, Josef; Schmidt, Reinhold; Ferrucci, Luigi; Shlipak, Michael G.; van Duijn, Cornelia M.; Borecki, Ingrid; Krämer, Bernhard K.; Rudan, Igor; Gyllensten, Ulf; Wilson, James F.; Witteman, Jacqueline C.; Pramstaller, Peter P.; Rettig, Rainer; Hastie, Nick; Chasman, Daniel I.; Kao, W. H.; Heid, Iris M.; Fox, Caroline S.

    2010-01-01

    Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 Caucasian individuals from 20 population-based studies to identify new susceptibility loci for reduced renal function, estimated by serum creatinine (eGFRcrea), cystatin C (eGFRcys), and CKD (eGFRcrea <60 ml/min/1.73m2; n = 5,807 CKD cases). Follow-up of the 23 genome-wide significant loci (p<5×10−8) in 22,982 replication samples identified 13 novel loci for renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2, and SLC7A9) and 7 creatinine production and secretion loci (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72, BCAS3). These results further our understanding of biologic mechanisms of kidney function by identifying loci potentially influencing nephrogenesis, podocyte function, angiogenesis, solute transport, and metabolic functions of the kidney. PMID:20383146

  9. Testing Strategies and Methodologies for the Max Launch Abort System

    NASA Technical Reports Server (NTRS)

    Schaible, Dawn M.; Yuchnovicz, Daniel E.

    2011-01-01

    The National Aeronautics and Space Administration (NASA) Engineering and Safety Center (NESC) was tasked to develop an alternate, tower-less launch abort system (LAS) as risk mitigation for the Orion Project. The successful pad abort flight demonstration test in July 2009 of the "Max" launch abort system (MLAS) provided data critical to the design of future LASs, while demonstrating the Agency s ability to rapidly design, build and fly full-scale hardware at minimal cost in a "virtual" work environment. Limited funding and an aggressive schedule presented a challenge for testing of the complex MLAS system. The successful pad abort flight demonstration test was attributed to the project s systems engineering and integration process, which included: a concise definition of, and an adherence to, flight test objectives; a solid operational concept; well defined performance requirements, and a test program tailored to reducing the highest flight test risks. The testing ranged from wind tunnel validation of computational fluid dynamic simulations to component ground tests of the highest risk subsystems. This paper provides an overview of the testing/risk management approach and methodologies used to understand and reduce the areas of highest risk - resulting in a successful flight demonstration test.

  10. Developments in Laser-Ablation Split-Stream Petrochronology

    NASA Astrophysics Data System (ADS)

    Kylander-Clark, Andrew R.

    2017-04-01

    One of the biggest challenges in assessing the timing and rates of petrogenesis and deformation is having the ability to match the age of a dated mineral to the conditions at which that mineral grew. This is especially challenging for high-temperature chonometers that can grow and remain stable over a wide range of pressures and temperatures. The development of the laser-ablation split-stream method has afforded the ability to rapidly aquire chemical and chronologic data that are directly linked; as such, timing and rates of processes are better constrained than before. Several examples are given within: 1) Zircon and monazite from a single, coesite-bearing sample from the Western Gneiss Region in western Norway record the entire 30+ Myr history of metamorphism during Caledonian orogenesis, from intial burial, through ultrahigh-pressure (UHP) conditions, and back to crustal levels. Early monazite ( 425 Ma) contains low concentrations of Sr and HREE, consistent with plagioclase and garnet stability during prograde metamorphism. 420-400 Ma ages from monazite (high Sr, increased Eu/Eu*, low HREE) and zircon (increased Eu/Eu*, low HREE) indicate the timing of HP conditions, and monazite with low Sr and high HREE indicates the breakdown of omphacite and garnet at 390 Ma. 2) Titanite is becoming more widely used as chronometer, primarly because laser ablation has made analysis more feasible. Nevertheless, dates produced from titanite can be difficult to interpret because titanite may alter more easily than zircon and monazite. LASS analyses of titanite, combined with X-ray maps and backscattered electron images provide insight into processes involved in growth, recrystallization and dissolution/reprecipitation, and allow us to better interpret ages and the geologic process that they represent. This study presents recrystallized titanite from metamorphic terranes as well as ocillatory-zoned titanite from igneous rocks, and suggests some possible processes that explain the

  11. Comparative chronology of Archean HT/UHT crustal metamorphism

    NASA Astrophysics Data System (ADS)

    Caddick, Mark; Dragovic, Besim; Guevara, Victor

    2017-04-01

    Attainment of high crustal heat fluxes and consequent partial melting is critical to the stabilization of continental roots. Understanding the processes and timescales behind partial melting of continental crust in the Archean is thus paramount for understanding Archean tectonic modes and how stable cratons formed. High-temperature (HT) to ultrahigh-temperature (UHT) metamorphic rocks can record evidence for dynamic processes that result in advective heat fluxes and a substantial deviation from normal crustal geothermal gradients. Examination of the pressure-temperature conditions and timescales of HT/UHT metamorphism is thus essential to understanding the tectonic processes behind extreme crust heat fluxes and the formation of stable cratonic crust. Here, utilizing both traditional and nontraditional petrologic and geochronologic techniques, we compare the pressure-temperature-time paths of two Neoarchean terranes: the eastern Beartooth Mountains of the Wyoming Craton and the Pikwitonei Granulite Domain of the Superior Province. The Beartooth Mountains of Montana, USA, expose Archean rocks of the Wyoming Craton that are dominated by an ˜2.8 Ga calc-alkaline granitoid batholith known as the Long Lake Magmatic Complex (LLMC). The LLMC contains widespread, up to km-scale metasedimentary roof pendants, with ID-TIMS Sm-Nd garnet geochronology and laser ablation split stream (LASS) monazite geochronology suggesting that metamorphism occurred almost 100 Ma after entrainment by the LLMC [1]. Phase equilibria modeling and Zr-in-rutile thermometry constrain peak pressures and temperatures of ˜6-7 kbar and ˜780-800˚ C. Major element diffusion modeling of garnet suggest that granulite-facies temperatures were only maintained for a short duration, < 2 Ma. In contrast, the Pikwitonei Granulite Domain consists of >150,000 km2 of high-grade metamorphic rocks situated in the NW Superior Province. Phase equilibria modeling and trace element thermometry constrain peak

  12. New Insights on 216 Kleopatra Based on Images Collected with the SPHERE Extreme AO System

    NASA Astrophysics Data System (ADS)

    Marchis, F.; Vernazza, P.; Hanus, J.; Marsset, M.; Yang, B.; Carry, B.; Santana-Ros, T.; Birlan, M.

    2017-12-01

    ESO allocated to our Large Asteroid Survey with SPHERE (LASS) program 152 hours of observations over four semesters (PI: Pierre Vernazza, run ID: 199.C-0074) to carry out disk-resolved images of 38 large (D≥100 km) main-belt asteroids (sampling the four main compositional classes) at high angular- resolution with VLT/SPHERE throughout their rotation in order to derive their 3-D shape, the size distribution of the largest craters, and their density. Here we focus on the analysis of SPHERE data taken in July 2017 of the triple asteroid (216) Kleopatra. Two tiny moons (3 & 5 km diameter) were discovered in September 2008 around the large (equivalent radius 67.5±2.9 km) M-type asteroid orbiting very close to the irregularly shaped primary at 300 and 700 km respectively (Descamps et al. 2010). With these additional data, our goals are i) to refine the average density of this interesting M-type asteroid ii) estimate its interior structure by detecting precession effects between the satellites iii) detect the presence of an additional moon which was suspected in W.M. Keck AO observation taken back in 2008. We will present this new data set, their analysis and new conclusion on the origins and formation of this asteroid.

  13. What do Seniors Remember from Freshman Physics?

    NASA Astrophysics Data System (ADS)

    Barrantes, Analia; Pawl, Andrew; Pritchard, David E.

    2009-11-01

    We have given a group of 56 MIT seniors who took mechanics as freshmen a written test similar to the final exam they took in their freshman course, plus the Mechanics Baseline Test (MBT) and Colorado Learning Attitudes about Science Survey (C-LASS) standard instruments. Students in majors unrelated to physics scored 60% lower on the written analytic part of the final than they did as freshmen. The mean score of all students on conceptual multiple choice questions included on the final also declined by about 60% relative to the scores of freshmen. The mean score of all participants on the MBT was insignificantly changed from the posttest taken as freshmen. More specifically, however, the students' performance on 9 of the 26 MBT items (with 6 of the 9 involving graphical kinematics) represents a gain over their freshman pretest score (a normalized gain of about 70%, double the gain achieved in the freshman course alone), while their performance on the remaining 17 questions is best characterized as a loss of approximately 50% of the material learned in the freshman course. Attitudinal survey results indicate that almost half the seniors feel the specific mechanics course content is unlikely to be useful to them, a significant majority (75-85%) feel that physics does teach valuable skills, and an overwhelming majority believe that mechanics should remain a required course at MIT.

  14. What do Seniors Remember from Freshman Physics?

    NASA Astrophysics Data System (ADS)

    Barrantes, Analia; Pawl, Andrew; Pritchard, David E.

    2009-10-01

    We have given a group of 56 MIT seniors who took mechanics as freshmen a written test similar to the final exam they took in their freshman course, plus the MBT and C-LASS standard instruments. Students in majors unrelated to physics scored 60% lower on the written analytic part of the final than they did as freshmen. The mean score of all students on conceptual multiple choice questions included on the final declined by approximately 50% relative to the scores of freshmen. The mean score of all participants on the MBT was insignificantly changed from the posttest taken as freshmen. More specifically, however, the students' performance on 9 of the 26 MBT items (with 6 of the 9 involving graphical kinematics) represents a gain over their freshman pretest score (a normalized gain of about 70%, double the gain achieved in the freshman course alone), while their performance on the remaining 17 questions is best characterized as a loss of approximately 50% of the material learned in the freshman course. Attitudinal survey results indicate that almost half the seniors feel the specific mechanics course content is unlikely to be useful to them, a significant majority (75-85%) feel that physics does teach valuable skills, and an overwhelming majority believe that mechanics should remain a required course at MIT.

  15. Liquid Engine Design: Effect of Chamber Dimensions on Specific Impulse

    NASA Technical Reports Server (NTRS)

    Hoggard, Lindsay; Leahy, Joe

    2009-01-01

    Which assumption of combustion chemistry - frozen or equilibrium - should be used in the prediction of liquid rocket engine performance calculations? Can a correlation be developed for this? A literature search using the LaSSe tool, an online repository of old rocket data and reports, was completed. Test results of NTO/Aerozine-50 and Lox/LH2 subscale and full-scale injector and combustion chamber test results were found and studied for this task. NASA code, Chemical Equilibrium with Applications (CEA) was used to predict engine performance using both chemistry assumptions, defined here. Frozen- composition remains frozen during expansion through the nozzle. Equilibrium- instantaneous chemical equilibrium during nozzle expansion. Chamber parameters were varied to understand what dimensions drive chamber C* and Isp. Contraction Ratio is the ratio of the nozzle throat area to the area of the chamber. L is the length of the chamber. Characteristic chamber length, L*, is the length that the chamber would be if it were a straight tube and had no converging nozzle. Goal: Develop a qualitative and quantitative correlation for performance parameters - Specific Impulse (Isp) and Characteristic Velocity (C*) - as a function of one or more chamber dimensions - Contraction Ratio (CR), Chamber Length (L ) and/or Characteristic Chamber Length (L*). Determine if chamber dimensions can be correlated to frozen or equilibrium chemistry.

  16. A platform for European CMOS image sensors for space applications

    NASA Astrophysics Data System (ADS)

    Minoglou, K.; San Segundo Bello, D.; Sabuncuoglu Tezcan, D.; Haspeslagh, L.; Van Olmen, J.; Merry, B.; Cavaco, C.; Mazzamuto, F.; Toqué-Trésonne, I.; Moirin, R.; Brouwer, M.; Toccafondi, M.; Preti, G.; Rosmeulen, M.; De Moor, P.

    2017-11-01

    Both ESA and the EC have identified the need for a supply chain of CMOS imagers for space applications which uses solely European sources. An essential requirement on this supply chain is the platformization of the process modules, in particular when it comes to very specific processing steps, such as those required for the manufacturing of backside illuminated image sensors. This is the goal of the European (EC/FP7/SPACE) funded project EUROCIS. All EUROCIS partners have excellent know-how and track record in the expertise fields required. Imec has been leading the imager chip design and the front side and backside processing. LASSE, as a major player in the laser annealing supplier sector, has been focusing on the optimization of the process related to the backside passivation of the image sensors. TNO, known worldwide as a top developer of instruments for scientific research, including space research and sensors for satellites, has contributed in the domain of optical layers for space instruments and optimized antireflective coatings. Finally, Selex ES, as a world-wide leader for manufacturing instruments with expertise in various space missions and programs, has defined the image sensor specifications and is taking care of the final device characterization. In this paper, an overview of the process flow, the results on test structures and imagers processed using this platform will be presented.

  17. Clinical Relevance of Ceramide Metabolism in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma (HNSCC): Attenuation of C18-ceramide in HNSCC Tumors Correlates with Lymphovascular Invasion and Nodal Metastasis

    PubMed Central

    Karahatay, Serdar; Thomas, Kesha; Koybasi, Serap; Senkal, Can E.; ElOjeimy, Saeed; Liu, Xiang; Bielawski, Jacek; Day, Terry A.; Boyd Gillespie, M; Sinha, Debajyoti; Norris, James S.; Hannun, Yusuf A.; Ogretmen, Besim

    2007-01-01

    It has been documented previously that defects in the generation of C18-ceramide, a product of ceramide synthase 1 (CerS1), also known as longevity assurance gene 1 (hLASS1), play important roles in the pathogenesis and/or progression of HNSCC. However, whether altered levels of ceramide generation in HNSCC tumors have any clinical relevance remains unknown. In this study, the levels of endogenous ceramides were measured in tumor tissues of 45 HNSCC patients as compared to their normal tissues using high-pressure liquid chromatography/mass spectrometry (LC/MS), and then possible link between ceramide levels and the clinical parameters of HNSCC were examined. The data showed that the levels of C16-, C24-, C24:1-ceramide were significantly elevated in the majority of tumor tissues compared to their normal tissues, while the levels of only C18-ceramide were significantly decreased in HNSCC tumors, especially in tumor tissues of male patients. Importantly, it was also shown here that decreased C18-ceramide levels in HNSCC tumor tissues were significantly associated with the higher incidences of lymphovascular invasion, and pathologic nodal metastasis. Importantly, attenuation of C18-ceramide was also positively linked to the higher overall stages of the primary HNSCC tumors. Therefore, these data suggest, for the first time, that the defects in the generation/accumulation of C18-ceramide might have important clinical roles in HNSCC, especially in lymphovascular invasion and nodal disease. PMID:17619081

  18. Reconnaissance geologic map and mineral resource potential of the Gearhart Mountain Wilderness and Roadless Area (6225), Lake and Klamath counties, Oregon

    USGS Publications Warehouse

    Walker, George W.; Ridenour, James

    1982-01-01

    The Gearhart Mountain Wilderness, Lake and Klamath Counties, Oreg., is devoid of mines and mineral prospects and there are no known mining claims within the area. Furthermore, the results of this mineral appraisal indicate that there is little likelihood that commercial deposits of metallic minerals will be found in the area. Commercial uranium deposits, like those at the White King and Lucky Lass mines about 16 mi (~25 km) to the southeast of the wilderness, and deposits of mercury, like those south-southeast of the wilderness, are not likely to be found within the wilderness, even though all of these areas are characterized by middle and late Cenozoic intrusive and extrusive volcanic rocks. Rock of low commercial value for construction purposes is present, but better and more accessible deposits are present in adjacent regions. There is no evidence to indicate that mineral fuels are present in the area. Higher than normal heat floe characterizes the region containing Gerheart Mountain, indicating that it may have some, as yet undefined, potential for the development of geothermal energy. Data are not available to determine whether this higher than normal heat flow is meaningful in terms of a potential energy source or as a guide to possible future exploration; lack of thermal springs or other evidence of localized geothermal anomalies within the Gerhart Mountain suggest, however, that the potential for the development of geothermal energy is probably low.

  19. Usefulness of ventricular endocardial electric reconstruction from body surface potential maps to noninvasively localize ventricular ectopic activity in patients

    NASA Astrophysics Data System (ADS)

    Lai, Dakun; Sun, Jian; Li, Yigang; He, Bin

    2013-06-01

    As radio frequency (RF) catheter ablation becomes increasingly prevalent in the management of ventricular arrhythmia in patients, an accurate and rapid determination of the arrhythmogenic site is of important clinical interest. The aim of this study was to test the hypothesis that the inversely reconstructed ventricular endocardial current density distribution from body surface potential maps (BSPMs) can localize the regions critical for maintenance of a ventricular ectopic activity. Patients with isolated and monomorphic premature ventricular contractions (PVCs) were investigated by noninvasive BSPMs and subsequent invasive catheter mapping and ablation. Equivalent current density (CD) reconstruction (CDR) during symptomatic PVCs was obtained on the endocardial ventricular surface in six patients (four men, two women, years 23-77), and the origin of the spontaneous ectopic activity was localized at the location of the maximum CD value. Compared with the last (successful) ablation site (LAS), the mean and standard deviation of localization error of the CDR approach were 13.8 and 1.3 mm, respectively. In comparison, the distance between the LASs and the estimated locations of an equivalent single moving dipole in the heart was 25.5 ± 5.5 mm. The obtained CD distribution of activated sources extending from the catheter ablation site also showed a high consistency with the invasively recorded electroanatomical maps. The noninvasively reconstructed endocardial CD distribution is suitable to predict a region of interest containing or close to arrhythmia source, which may have the potential to guide RF catheter ablation.

  20. What do kids think about kids in eyeglasses?

    PubMed

    Walline, Jeffrey J; Sinnott, Loraine; Johnson, Erica D; Ticak, Anita; Jones, Sylvia L; Jones, Lisa A

    2008-05-01

    Previous studies have examined how people feel about others who wear glasses, but no studies of children have been published on the subject. We conducted the Children's Attitudes about Kids in Eyeglasses (CAKE) study to determine how children feel about other children who wear glasses. Subjects compared a series of 24 picture pairs and answered six questions regarding which child ...he or she would rather play with, looks better at playing sports, appears smarter (more intelligent), appears nicer, looks more shy and looks more honest. The children in each pair of pictures differed by gender, ethnicity and spectacle wear. Logistic regression was performed to determine the probability and confidence interval that a subject would pick a particular child. Eighty subjects between the ages of 6 and 10 years participated. The average (+/-SD) age of the subjects was 8.3 +/- 1.3 years, 42 (53%) were females, 51 (64%) were whites, 21 (26%) were blacks, and 30 (38%) wore glasses. The spectacle wearer appeared smarter (0.66, CI = 0.60-0.71) and more honest (0.57, CI = 0.50-0.64), and children who wore glasses looked smarter regardless of whether the child picking wore glasses. Both boys (0.66, CI = 0.68-0.79) and girls (0.77, CI = 0.71-0.82) thought that boys looked better at playing sports. The old adage 'Boys never make passes at lasses who wear glasses' may be outmoded, but glasses may tend to make children look smarter and slightly more honest to their peers.

  1. A place-based model of local activity spaces: individual place exposure and characteristics

    NASA Astrophysics Data System (ADS)

    Hasanzadeh, Kamyar; Laatikainen, Tiina; Kyttä, Marketta

    2018-01-01

    Researchers for long have hypothesized relationships between mobility, urban context, and health. Despite the ample amount of discussions, the empirical findings corroborating such associations remain to be marginal in the literature. It is growingly believed that the weakness of the observed associations can be largely explained by the common misspecification of the geographical context. Researchers coming from different fields have developed a wide range of methods for estimating the extents of these geographical contexts. In this article, we argue that no single approach yet has sufficiently been capable of capturing the complexity of human mobility patterns. Subsequently, we discuss that reaching a better understanding of individual activity spaces can be possible through a spatially sensitive estimation of place exposure. Following this discussion, we take an integrative person and place-based approach to create an individualized residential exposure model (IREM) to estimate the local activity spaces (LAS) of the individuals. This model is created using data collected through public participation GIS. Following a brief comparison of IREM with other commonly used LAS models, the article continues by presenting an empirical study of aging citizens in Helsinki area to demonstrate the usability of the proposed framework. In this study, we identify the main dimensions of LASs and seek their associations with socio-demographic characteristics of individuals and their location in the region. The promising results from comparisons and the interesting findings from the empirical part suggest both a methodological and conceptual improvement in capturing the complexity of local activity spaces.

  2. Heat Transfar Properties of Flat-Panel Evacuated Porous Insrlators

    NASA Astrophysics Data System (ADS)

    Yoneno, Hirosyi; Yamamoto, Ryoichi

    Flat Panel evacuated porous insulators have been produced by filling powder or fiber (such as perlite powder, diatomaceous earth powder, silica aerogel powder, g lass fiber and ceramic fiber) in film-like laminated plastic container and by evacuating to form vacuum in it is interior. Heat transfer properties of these evacuated insulators have been studied under various conditions (such as particle diameter, surface area, packing density, solid volume fraction and void dimension). The apparent mean thermal conductivity has been measured for the boundary surface temperature at cold face temperature 13°C and hot face temperature 35°. The effect of air pressure ranging from 1 Pa to one atomosphere (105 Pa) was examined. The results were as follows. (1) For each powder the apparent mean thermal conductivity decreases with decreasing residual air pressure, and at very low pressure bellow 1 -103 Pa the conductivity becomes indeqendent of pressure. The thermal conductivity at 1.3Pa is 0.0053 W/mK for perlite powder, 0.0048W/mK for diatomaceous earth powder, 0.0043 W/mK for silica aerogel powder and 0.0029W/mK for glass fiber. (2) With decreasing particle size, the apparent mean thermal conductivity is constant independent of residual air pressure in higher pressure region. It is that void dimension continues to decrease with particle size and the mean free path of air becomes comparable with void dimension. (3) In the range of minor solid volume fraction, the apparent mean thermal conductivity at very low precreases with decreasing particle size. This shows the thermal contact resistance of the solid particle increases with decreasing particle size.

  3. ASPECT: A Survey to Assess Student Perspective of Engagement in an Active-Learning Classroom.

    PubMed

    Wiggins, Benjamin L; Eddy, Sarah L; Wener-Fligner, Leah; Freisem, Karen; Grunspan, Daniel Z; Theobald, Elli J; Timbrook, Jerry; Crowe, Alison J

    2017-01-01

    The primary measure used to determine relative effectiveness of in-class activities has been student performance on pre/posttests. However, in today's active-learning classrooms, learning is a social activity, requiring students to interact and learn from their peers. To develop effective active-learning exercises that engage students, it is important to gain a more holistic view of the student experience in an active-learning classroom. We have taken a mixed-methods approach to iteratively develop and validate a 16-item survey to measure multiple facets of the student experience during active-learning exercises. The instrument, which we call A ssessing S tudent P erspective of E ngagement in C lass T ool (ASPECT), was administered to a large introductory biology class, and student responses were subjected to exploratory factor analysis. The 16 items loaded onto three factors that cumulatively explained 52% of the variation in student response: 1) value of activity, 2) personal effort, and 3) instructor contribution. ASPECT provides a rapid, easily administered means to measure student perception of engagement in an active-learning classroom. Gaining a better understanding of students' level of engagement will help inform instructor best practices and provide an additional measure for comprehensively assessing the impact of different active-learning strategies. © 2017 B. L. Wiggins, S. L. Eddy, et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  4. Vom Urknall zum Durchknall

    NASA Astrophysics Data System (ADS)

    Unzicker, Alexander

    Lautstarker Applaus erhob sich im Salon III/IV des Marriott-Hotels von Crystal City im amerikanischen Bundesstaat Virginia. In dem überfüllten Konferenzraum starrten alle wie gebannt auf die Leinwand, wo nicht mehr zu sehen war als ein nüchternes Diagramm aus zahlreichen Punkten und einer geschwungenen Kurve. Nureine eigenartige Personengruppe konnte sich davon zu Emotionen hinreißen lassen - Physiker auf der Jahrestagung der Astronomischen Gesellschaft, die ihren Begeisterungssturm noch minutenlang fortsetzten. Was war geschehen? Die im Diagramm aufgetragenen Daten bestätigten mit einer nie da gewesenen Genauigkeit ein fundamentales Naturgesetz zur Wärmeabstrahlung von heißen Körpern. 1900 von Max Planck entdeckt, leuchtete es nun in geradezu mathematischer Reinheit auf. Noch sensationeller war der Ursprung der Daten - Mikrowellensignale verschiedener Frequenzen, die nicht aus einem irdischen Labor stammten, sondern von einem heißen Urzustand des Universums! Ein Feuerball aus Wasserstoff und Helium, noch ohne jegliche Strukturen, die irgendwann Leben ermöglichen sollten, ließ damals seinem Licht freien Lauf. Mehr als zehn Milliarden Jahre war es bis zu den Detektoren des vom Menschen gebauten Satelliten COBE unterwegs, der wenige Tage zuvor die Daten übertragen hatte. Wenn ich das alles wie einen Film in meiner Vorstellung ablaufen lasse, bekomme ich immer eine Gänsehaut, als würde ich die inzwischen extrem abgekühlte Strahlung tatsächlich spüren. Ihre Gleichverteilung im Raum macht uns auch deutlich, dass wir uns nicht einbilden dürfen, an einem besonderen Ort im Universum zu leben - intelligente Aliens könnten sich seitdem überall entwickelt haben! Sollten sie - was nicht wahrscheinlich ist - uns wirklich von Zeit zu Zeit über die Schulter schauen, dann hätten sie an jenem Nachmittag des 13. Januar 1990, als der Vortrag stattfand, bestimmt anerkennend mit ihrem großen Kopf genickt.

  5. Reducing social inequalities in access to overweight and obesity care management for adolescents: The PRALIMAP-INÈS trial protocol and inclusion data analysis.

    PubMed

    Legrand, Karine; Lecomte, Edith; Langlois, Johanne; Muller, Laurent; Saez, Laura; Quinet, Marie-Hélène; Böhme, Philip; Spitz, Elisabeth; Omorou, Abdou Y; Briançon, Serge

    2017-09-01

    Despite social inequalities in overweight/obesity prevalence, evidence-based public health interventions to reduce them are scarce. The PRALIMAP-INÈS trial aimed to investigate whether a strengthened-care management for adolescents with low socioeconomic status has an equivalent effect in preventing and reducing overweight as a standard-care management for high socioeconomic status adolescents. PRALIMAP-INÈS was a mixed, prospective and multicenter trial including 35 state-run schools. It admitted overweight or obese adolescents, age 13-18 years old, for 3 consecutive academic years. One-year interventions were implemented. Data were collected before (T0), after (T1) and post (T2) intervention. Among 2113 eligible adolescents who completed questionnaires, 1639 were proposed for inclusion and 1419 were included (220 parental refusals). Two groups were constituted according to the Family Affluence Scale (FAS) score: the less advantaged (FAS≤5) were randomly assigned to 2 groups in a 2/1 ratio. The 3 intervention groups were: advantaged with standard-care management (A.S, n = 808), less advantaged with standard-care management (LA.S, n = 196), and less advantaged with standard and strengthened-care management (LA.S.S, n = 415). The standard-care management was based on the patient education principle and consisted of 5 collective sessions. The strengthened-care management was based on the proportionate universalism principle and consisted of activities adapted to needs. The written parental refusal was less frequent among less advantaged and more overweight adolescents. A dramatic linear social gradient in overweight was evidenced. The PRALIMAP-INÈS outcomes should inform how effectively a socially adapted public health program can avoid worsening social inequalities in overweight adolescents attending school. ClinicalTrials.gov (NCT01688453).

  6. Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

    PubMed Central

    da Silva, Jaqueline S; Gabriel-Costa, Daniele; Sudo, Roberto T; Wang, Hao; Groban, Leanne; Ferraz, Emanuele B; Nascimento, José Hamilton M; Fraga, Carlos Alberto M; Barreiro, Eliezer J; Zapata-Sudo, Gisele

    2017-01-01

    Background This work evaluated the hypothesis that 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294), an agonist of adenosine A2A receptor, could be beneficial for preventing cardiac dysfunction due to hypertension associated with myocardial infarction (MI). Methods Male spontaneously hypertensive rats (SHR) were randomly divided into four groups (six animals per group): sham-operation (SHR-Sham), and myocardial infarction rats (SHR-MI) were treated orally either with vehicle or LASSBio-294 (10 and 20 mg.kg−1.d−1) for 4 weeks. Echocardiography and in vivo hemodynamic parameters measured left ventricle (LV) structure and function. Exercise tolerance was evaluated using a treadmill test. Cardiac remodeling was accessed by LV collagen deposition and tumor necrosis factor α expression. Results Early mitral inflow velocity was significantly reduced in the SHR-MI group, and there was significant recovery in a dose-dependent manner after treatment with LASSBio-294. Exercise intolerance observed in the SHR-MI group was prevented by 10 mg.kg−1.d−1 of LASS-Bio-294, and exercise tolerance exceeded that of the SHR-Sham group at 20 mg.kg−1.d−1. LV end-diastolic pressure increased after MI, and this was prevented by 10 and 20 mg.kg−1.d−1 of LASSBio-294. Sarcoplasmic reticulum Ca2+ ATPase levels were restored in a dose-dependent manner after treatment with LASSBio-294. Fibrosis and inflammatory processes were also counteracted by LASSBio-294, with reductions in LV collagen deposition and tumor necrosis factor α expression. Conclusion In summary, oral administration of LASSBio-294 after MI in a dose-dependent manner prevented the development of cardiac dysfunction, demonstrating this compound’s potential as an alternative treatment for heart failure in the setting of ischemic heart disease with superimposed chronic hypertension. PMID:28293100

  7. Accessory Mineral Depth-Profiling Applied to the Corsican Lower Crust: A Continuous Thermal History of Mesozoic Continental Rifting

    NASA Astrophysics Data System (ADS)

    Seymour, N. M.; Stockli, D. F.; Beltrando, M.; Smye, A.

    2015-12-01

    Despite advances in understanding the structural development of hyperextended magma-poor rift margins, the temporal and thermal evolution of lithospheric hyperextension during rifting remains only poorly understood. In contrast to classic pure-shear models, multi-stage rift models that include depth-dependent thinning predict significant lower-crustal reheating during the necking phase due to buoyant rise of the asthenosphere. The Santa Lucia nappe of NE Corsica is an ideal laboratory to test for lower-crustal reheating as it preserves Permian lower crust exhumed from granulitic conditions during Mesozoic Tethyan rifting. This study presents the first use of apatite U-Pb depth-profile thermochronology in conjunction with novel rutile U-Pb and zircon U-Pb thermo- and geochronology to reconstruct a continuous t-T path to constrain the syn-rift thermal evolution of this exposed lower-crustal section. LASS-ICP-MS depth-profile analyses of zircon reveal thin (<10 μm) ~210-180 Ma overgrowths on 300-270 Ma cores in lower-crustal lithologies, indicative of renewed thermal activity during Mesozoic rifting. Cooling due to rapid rift margin exhumation is recorded by the topology of rutile and apatite depth profiles caused by thermally-activated volume diffusion at T >400°C. Lower-crustal rutile reveal a rounded progression from core plateaus at ~170 Ma to 150-145 Ma at the outer 8-10 μm of grains while middle-crustal apatite records 170 Ma cores grading to 140-135 Ma rims. Inverse modeling of rutile profiles suggests the lower crust cooled from 700°C at 200 Ma to 425°C at 140 Ma. Middle-crustal apatite yield a two-stage history, with rapid cooling from 500°C at 200 Ma to 420°C at ~180 Ma followed by slow cooling to 400°C by 160 Ma. Combined with zircon overgrowth ages, these data indicate the Santa Lucia nappe underwent a thermal pulse in the late Triassic-early Jurassic associated with depth-dependent thinning and hyperextension of the Corsican margin.

  8. Two modes of orogenic collapse of the Pamir plateau recorded by titanite

    NASA Astrophysics Data System (ADS)

    Stearns, M. A.; Hacker, B. R.; Ratschbacher, L.; Rutte, D.; Kylander-Clark, A. R.

    2013-12-01

    Processes that operate in the mid- to lower crust during and following continent-continent collision are important for understanding how orogenic plateaux transition from thickening to collapse. In the central and southern Pamir, mid- to lower crustal rocks crop out in two belts of extensional domes. The central Pamir domes were exhumed by symmetrical N-S extension. In contrast, the southern Pamir domes were exhumed by asymmetrical top to the south (NNW-SSE) extension via a rolling-hinge detachment. To investigate the high-temperature exhumation history, titanites were dated using LASS (laser ablation split stream-ICP-MS). A multi-collector ICP was used to collect U-Pb isotopic ratios and a single collector ICP-MS was used to measure trace-element abundances. The data indicate that the central Pamir domes began exhumation synchronously at ~17 Ma. Titanite from the southern Pamir record two periods of protracted (re)crystallization: older metamorphic dates ranging from ~35-18 Ma and younger igneous and metamorphic dates from ~15-7 Ma. Samples with single populations of titanite dates are present throughout both groups. Samples with more-complex date populations typically have distinct trace-element (e.g., Sr, Y, Zr, and Nb) groups that can be used to distinguish different date populations (e.g., older dates may have higher Zr and younger dates lower Zr). The distinct early exhumation histories of the north and south Pamir require either a diachronous single process or two semi-independent processes. The N to S sequence of exhumation, ranges of dates, and overall extension directions may be related to two important plate-tectonic events inferred from seismic data: 1) breakoff of the northward subducting Indian slab around ~20 Ma, and 2) southward subduction and northwestward rollback of the Asian lithosphere between ~15-10 Ma based on geodetic convergence rates and Benioff zone length. We interpret these two lithospheric-detachment events to have driven the

  9. On the Discrepancy in Simultaneous Observations of the Structure Parameter of Temperature Using Scintillometers and Unmanned Aircraft

    NASA Astrophysics Data System (ADS)

    Braam, Miranda; Beyrich, Frank; Bange, Jens; Platis, Andreas; Martin, Sabrina; Maronga, Björn; Moene, Arnold F.

    2016-02-01

    We elaborate on the preliminary results presented in Beyrich et al. (in Boundary-Layer Meteorol 144:83-112, 2012), who compared the structure parameter of temperature ({CT^2}_{}) obtained with the unmanned meteorological mini aerial vehicle (M2 AV) versus {CT^2}_{} obtained with two large-aperture scintillometers (LASs) for a limited dataset from one single experiment (LITFASS-2009). They found that {CT^2}_{} obtained from the M2 AV data is significantly larger than that obtained from the LAS data. We investigate if similar differences can be found for the flights on the other six days during LITFASS-2009 and LITFASS-2010, and whether these differences can be reduced or explained through a more elaborate processing of both the LAS data and the M2 AV data. This processing includes different corrections and measures to reduce the differences between the spatial and temporal averaging of the datasets. We conclude that the differences reported in Beyrich et al. can be found for other days as well. For the LAS-derived values the additional processing steps that have the largest effect are the saturation correction and the humidity correction. For the M2 AV -derived values the most important step is the application of the scintillometer path-weighting function. Using the true air speed of the M2 AV to convert from a temporal to a spatial structure function rather than the ground speed (as in Beyrich et al.) does not change the mean discrepancy, but it does affect {CT^2}_{} values for individual flights. To investigate whether {CT^2}_{} derived from the M2 AV data depends on the fact that the underlying temperature dataset combines spatial and temporal sampling, we used large-eddy simulation data to analyze {CT^2}_{} from virtual flights with different mean ground speeds. This analysis shows that {CT^2}_{} does only slightly depends on the true air speed when averaged over many flights.

  10. Area-averaged evapotranspiration over a heterogeneous land surface: aggregation of multi-point EC flux measurements with a high-resolution land-cover map and footprint analysis

    NASA Astrophysics Data System (ADS)

    Xu, Feinan; Wang, Weizhen; Wang, Jiemin; Xu, Ziwei; Qi, Yuan; Wu, Yueru

    2017-08-01

    The determination of area-averaged evapotranspiration (ET) at the satellite pixel scale/model grid scale over a heterogeneous land surface plays a significant role in developing and improving the parameterization schemes of the remote sensing based ET estimation models and general hydro-meteorological models. The Heihe Watershed Allied Telemetry Experimental Research (HiWATER) flux matrix provided a unique opportunity to build an aggregation scheme for area-averaged fluxes. On the basis of the HiWATER flux matrix dataset and high-resolution land-cover map, this study focused on estimating the area-averaged ET over a heterogeneous landscape with footprint analysis and multivariate regression. The procedure is as follows. Firstly, quality control and uncertainty estimation for the data of the flux matrix, including 17 eddy-covariance (EC) sites and four groups of large-aperture scintillometers (LASs), were carefully done. Secondly, the representativeness of each EC site was quantitatively evaluated; footprint analysis was also performed for each LAS path. Thirdly, based on the high-resolution land-cover map derived from aircraft remote sensing, a flux aggregation method was established combining footprint analysis and multiple-linear regression. Then, the area-averaged sensible heat fluxes obtained from the EC flux matrix were validated by the LAS measurements. Finally, the area-averaged ET of the kernel experimental area of HiWATER was estimated. Compared with the formerly used and rather simple approaches, such as the arithmetic average and area-weighted methods, the present scheme is not only with a much better database, but also has a solid grounding in physics and mathematics in the integration of area-averaged fluxes over a heterogeneous surface. Results from this study, both instantaneous and daily ET at the satellite pixel scale, can be used for the validation of relevant remote sensing models and land surface process models. Furthermore, this work will be

  11. Nd Isotope and U-Th-Pb Age Mapping of Single Monazite Grains by Laser Ablation Split Stream Analysis

    NASA Astrophysics Data System (ADS)

    Fisher, C. M.; Hanchar, J. M.; Miller, C. F.; Phillips, S.; Vervoort, J. D.; Martin, W.

    2015-12-01

    Monazite is a common accessory mineral that occurs in medium to high grade metamorphic and Ca-poor felsic igneous rocks, and often controls the LREE budget (including Sm and Nd) of the host rock in which it crystallizes. Moreover, it contains appreciable U and Th, making it an ideal mineral for determining U-Th-Pb ages and Sm-Nd isotopic compositions, both of which are readily determined using in situ techniques with very high spatial resolution like LA-MC-ICPMS. Here, we present the results of laser ablation split stream analyses (LASS), which allows for simultaneous determination of the age and initial Nd isotopic composition in a single analysis. Analyses were done using a 20mm laser spot that allowed for detailed Nd isotope mapping of monazite grains (~30 analyses per ~250mm sized grain). Combined with LREE ratios (e.g., Sm/Nd, Ce/Gd, and Eu anomalies) these results yield important petrogenetic constraints on the evolution of peraluminous granites from the Old Woman-Piute batholith in southeastern California. Our findings also allow an improved understanding of the causes of isotope heterogeneity in granitic rocks. U-Th-Pb age mapping across the crystals reveals a single Cretaceous age for all grains with precision and accuracy typical of laser ablation analyses (~2%). In contrast, the concurrent Nd isotope mapping yields homogeneous initial Nd isotope compositions for some grains and large initial intra-grain variations of up to 8 epsilon units in others. The grains that yield homogeneous Nd isotope compositions have REE ratios suggesting that they crystallized in a fractionally crystallizing magma. Conversely, other grains, which also record fractional crystallization of both feldspar and LREE rich minerals, demonstrate a change in the Nd isotope composition of the magma during crystallization of monazite. Comparison of inter- and intra-grain Nd isotope compositions reveals further details on the potential mechanisms responsible for isotope heterogeneity

  12. Contemporaneous migmitization and granite emplacement during regional metamorphism: Evidence for mid-crustal contribution to the batholiths of the Arabian-Nubian Shield

    NASA Astrophysics Data System (ADS)

    Elisha, B.; Katzir, Y.; Kylander-Clark, A. R.

    2017-12-01

    Collision-related granitoid batholiths, like those of the Hercynian and Himalayan orogens, are mostly fed by magma derived from meta-sedimentary sources. However, in the late Neoproterozoic calc-alkaline batholiths of the Arabian Nubian Shield (ANS), which constitutes the northern half of the East African orogen, sedimentary contribution is obscured by the juvenile character of the crust and the scarcity of migmatites. Here we use paired in-situ measurements of U-Th-Pb isotope ratios and REE contents of monazite and xenotime by LASS to demonstrate direct linkage between granites and migmatites in the northernmost ANS. Our results indicate a single prolonged period of monazite growth, 640-600 Ma, in metapelites, migmatites and peraluminous granites of the Abu-Barqa (SW Jordan), Roded (S Israel) and Taba-Nuweiba (Sinai, Egypt) metamorphic suites. Distribution of monazite dates and age zoning in single monazite grains in migmatites suggest that peak thermal conditions and partial melting prevailed for 10 Myr, from 620 to 610 Ma. REE patterns of monazite are well correlated with age, recording garnet growth and garnet breakdown in association with the prograde and retrograde stages of the melting reactions, respectively. Xenotime dates (n=40) cluster at 600-580 Ma recording retrogression to greenschist-facies conditions as garnet continues to destabilize. Phase equilibrium modelling and mineral thermobarometry illustrate that melting occurred either by dehydration of muscovite or by water-fluxed melting at 650-680° and 5-7 kbar. The expected melt production is 8-14%, allowing melt connectivity network to form and eventually melt extraction and segregation. The crystallization time of peritectic melt retained in dia- and metataxites overlaps the emplacement time of a vast calc-alkaline granitic flux throughout the northern ANS, which was previously considered post-collisional. Similar monazite ages ( 620 Ma) of the amphilolite-facies non-anatectic Elat schist indicate

  13. Comments on the article entitled “Incompatibility of the Shuttleworth equation with Hermann’s mathematical structure of thermodynamics” by D.J. Bottomley, Lasse Makkonen and Kari Kolari [Surf. Sci. 603 (2009) 97

    NASA Astrophysics Data System (ADS)

    Hecquet, Pascal

    2010-02-01

    In the Shuttleworth's equation gij=γδij+dγ/dɛij, γ is the surface energy and gij is the surface stress with respect to the corresponding bulk quantity. At equilibrium and T=0 K, the bulk energy is the cohesive energy and the bulk stress is zero ( p=0). For i=j ( ɛii is hydrostatic) and for a flat surface, we show that the equilibrium surface stress gii corresponds to a surface pressure located mainly at the first monolayer and that the presence of the surface energy γ in the Shuttleworth's equation results from the matter conservation rule. Indeed, γ is an energy calculated per constant unit area while the atomic surface varies with the deformation as ( 1+ɛii). The equilibrium surface stress gii present at the surface is parallel to the surface. When gii is positive, this signifies that the surface atoms tend to contract together in the direction i even if the bulk pressure p is zero.

  14. The Wall-Rock Record of Incremental Emplacement in the Little Cottonwood-Alta Magmatic and Hydrothermal System, Wasatch Mountains, Utah, U.S.A.

    NASA Astrophysics Data System (ADS)

    Stearns, M.; Callis, S.; Beno, C.; Bowman, J. R.; Bartley, J. M.

    2017-12-01

    Contact aureoles record the cumulative effects on wall rocks of magma emplacement. Like the plutons they surround, contact aureoles have long been regarded to form geologically instantaneously. Protracted incremental emplacement of plutons must be reconciled with the wall-rock record of heat and mass transfer. Fundamental questions include how heat and material move from intrusions into their aureoles and how long that process takes. The Little Cottonwood stock is surrounded by a 2 km-wide contact aureole that contains prograde AFM mineral assemblages in the pelitic layers of the Proterozoic Big Cottonwood Formation. The Alta stock is surrounded by a well characterized 1 km-wide contact aureole containing both prograde AFM and CMS mineral assemblages in Ophir Shale and Mississippian dolostones, respectively. Understanding the petrogenesis of these aureoles requires the timing of magmatism and wall-rock metamorphism to be independently determined. Preliminary petrochronology (U/Th-Pb dates and trace element concentrations collected by LASS-ICP-MS) from the inner aureoles of both intrusions establishes a protracted history of monazite (re)crystallization from 35-25 Ma in the Little Cottonwood aureole and 35 Ma in the Alta aureole. Little Cottonwood aureole monazites are characterized by a positive age correlation with heavy rare earth elements (HREE) and a negative correlation with Eu/Eu*. Alta aureole monazites have a similar range of the HREE concentrations and Eu/Eu* variation. Zircon growth interpreted to record emplacement-level magmatic crystallization of the western Little Cottonwood stock ranges from 33-28 Ma near the contact. Multi-grain U-Pb zircon TIMS dates from the Alta stock range from 35-33 Ma and are interpreted to suggest the full range of emplacement-level magmatism in the Alta stock. Additionally, in situ U-Pb titanite dates from the Alta stock record intermittent high temperature hydrothermal activity in the stock margin from 35-24 Ma. These new

  15. The importance of intracrustal magmatic heat advection in large hot orogens: the Ediacaran-Cambrian ultrahigh-temperature domain of southern Madagascar.

    NASA Astrophysics Data System (ADS)

    Holder, R. M.; Hacker, B. R.

    2016-12-01

    Ultrahigh temperature metamorphism (UHTM) represents the thermal extremes of crustal metamorphism and is integral to our understanding of orogenic systems and continental evolution. The relative importance of advective and radiogenic heating in UHTM is often unclear, however, due to retrogression of UHT mineral assemblages and lack of robust chronology. We report the first observation of osumilite, pseudosections, feldspar thermometry, and monazite LASS U-Th-Pb chronology from the Ediacaran-Cambrian Anosyen domain of southern Madagascar to evaluate P-T-time paths and assess the relative importance of advective and radiogenic heating. Pseudosections of an osumilite-bearing assemblage, a garnet-orthopyroxene gneiss, and a garnet-spinel leucogneiss indicate peak conditions of 930-1010 C, 4-6 kbar; 900-950 C, 6-7 kbar; and 970-1000 C, 4.5-5.5 kbar, respectively. Feldspar thermometry indicates T > 915 ± 30 C. These conditions were reached along a low-P prograde path, as implied by cordierite and sillimanite inclusions in garnet. Monazite and zircon U/Th-Pb dating indicates that prograde metamorphism began 625 Ma and lasted 60 Myr. The timing of peak metamorphism is constrained to a 16 ± 2.5 Myr period between 566 ± 2 and 550 ± 1.5 Ma, by monazite inclusions in pseudomorphs after osumilite and monazite from a leucosome in the same outcrop. Peak T was achieved immediately following emplacement of voluminous charnockites (emplaced 1000-1100 C) and related magmas of the Anosyen Batholith. Crystallization of pegmatite dikes, leucosomes, and smaller plutons during cooling lasted from 550 to 510 Ma. This broad thermal history is also recorded by metamorphic monazite Eu/Eu*, which indicate progressive melt generation and extraction prior to 550 Ma followed by melt accumulation and crystallization after 550 Ma. Although the duration of prograde metamorphism is consistent with radiogenic heating models of large hot orogens, peak T was 100-200 C higher in southern Madagascar

  16. Engineering and Scientific Applications: Using MatLab(Registered Trademark) for Data Processing and Visualization

    NASA Technical Reports Server (NTRS)

    Sen, Syamal K.; Shaykhian, Gholam Ali

    2011-01-01

    MatLab(R) (MATrix LABoratory) is a numerical computation and simulation tool that is used by thousands Scientists and Engineers in many cou ntries. MatLab does purely numerical calculations, which can be used as a glorified calculator or interpreter programming language; its re al strength is in matrix manipulations. Computer algebra functionalities are achieved within the MatLab environment using "symbolic" toolbo x. This feature is similar to computer algebra programs, provided by Maple or Mathematica to calculate with mathematical equations using s ymbolic operations. MatLab in its interpreter programming language fo rm (command interface) is similar with well known programming languag es such as C/C++, support data structures and cell arrays to define c lasses in object oriented programming. As such, MatLab is equipped with most ofthe essential constructs of a higher programming language. M atLab is packaged with an editor and debugging functionality useful t o perform analysis of large MatLab programs and find errors. We belie ve there are many ways to approach real-world problems; prescribed methods to ensure foregoing solutions are incorporated in design and ana lysis of data processing and visualization can benefit engineers and scientist in gaining wider insight in actual implementation of their perspective experiments. This presentation will focus on data processing and visualizations aspects of engineering and scientific applicati ons. Specifically, it will discuss methods and techniques to perform intermediate-level data processing covering engineering and scientifi c problems. MatLab programming techniques including reading various data files formats to produce customized publication-quality graphics, importing engineering and/or scientific data, organizing data in tabu lar format, exporting data to be used by other software programs such as Microsoft Excel, data presentation and visualization will be discussed. The presentation will emphasize creating

  17. Acquiring Comprehensive Observations using an Integrated Sensorweb for Early Warning

    NASA Technical Reports Server (NTRS)

    Habib, Shahid; Ambrose, Steve

    2006-01-01

    As an integrated observing strategy, the concept of sensorweb for Earth observations is appealing in many aspects. For instance, by increasing the spatial and temporal coverage of observations from space and other vantage points, one can eventually aid in increasing the accuracy of the atmospheric models which are precursor to hurricane track prediction, volcanic eruption forecast, and trajectory path of transcontinental transport of dust, harmful nuclear and chemical plumes. In reality, there is little analysis'available in terms of benefits, costs and optimized set of sensors needed to make these necessary observations. This is a complex problem that must be carefully studied and balanced over many boundaries such as science, defense, early warning security, and surveillance. Simplistically, the sensorweb concept from the technological point of view alone has a great appeal in the defense, early warning and security applications. In fact, it can be relatively less expensive in per unit cost as opposed to building and deploying it for the scientific use. However, overall observing approach should not be singled out and aligned somewhat . orthogonally to serve a particular need. On the other hand, the sensorweb should be designed and deployed to serve multiple subject areas and customers simultaneously; and can behave as directed measuring systems for both science and operational entities. Sensorweb can be designed to act as expert systems, and/or also provide a dedicated integrated surveillance network. Today, there is no system in the world that is fully integrated in terms of reporting timely multiple hazards warnings, computing the lass of life and property damage estimates, and is also designed to cater to everyone's needs. It is not an easier problem to undertake and more so is not practically solvable. At this time due to some recent events in the world, the scientific community, social scientists, and operational agencies are more cognizant and getting

  18. Lost in Translation

    NASA Astrophysics Data System (ADS)

    Lass, Wiebke; Reusswig, Fritz

    2014-05-01

    Lost in Translation? Introducing Planetary Boundaries into Social Systems. Fritz Reusswig, Wiebke Lass Potsdam Institute for Climate Impact Research, Potsdam, Germany Identifying and quantifying planetary boundaries by interdisciplinary science efforts is a challenging task—and a risky one, as the 1972 Limits to Growth publication has shown. Even if we may be assured that scientific understanding of underlying processes of the Earth system has significantly improved since then, the challenge of translating these findings into the social systems of the planet remains crucial for any kind of action, and in many respects far more challenging. We would like to conceptualize what could also be termed a problem of coupling social and natural systems as a nested set of social translation processes, well aware of the limited applicability of the language-related translation metaphor. Societies must, first, perceive these boundaries, and they have to understand their relevance. This includes, among many other things, the organization of transdisciplinary scientific cooperation. They will then have to translate this understood perception into possible actions, i.e. strategies for different local bodies, actors, and institutional settings. This implies a lot of 'internal' translation processes, e.g. from the scientific subsystem to the mass media, the political and the economic subsystem. And it implies to develop subsystem-specific schemes of evaluation for these alternatives, e.g. convincing narratives, cost-benefit analyses, or ethical legitimacy considerations. And, finally, societies do have to translate chosen action alternatives into monitoring and evaluation schemes, e.g. for agricultural production or renewable energies. This process includes the continuation of observing and re-analyzing the planetary boundary concept itself, as a re-adjustment of these boundaries in the light of new scientific insights cannot be excluded. Taken all together, societies may well

  19. Ediacaran ( 620 Ma) high grade regional metamorphism in the northern Arabian Nubian Shield: U/Th-Pb monazite ages of the Elat schist

    NASA Astrophysics Data System (ADS)

    Elisha, Bar; Katzir, Yaron; Kylander-Clark, Andrew

    2017-04-01

    Ediacaran times witnessed a hemisphere-scale orogenesis forming the extensive Pan-African mountain ranges and resulting in the final assembly of Gondwana supercontinent. The Elat metamorphic basement (S Israel) located at the northernmost tip of a major Pan-African orogenic suture, the Arabian Nubian Shield (ANS), comprises amphibolite facies schists and gneisses and was most likely shaped by this major continental collision. However the timing, number and duration of metamorphic events in Elat and elsewhere in the ANS are non-conclusive and a major emphasis was given to pre-Ediacaran island-arc related tectonics. This is mostly because U-Pb dating of zircon, widely used in Elat and elsewhere, is very successful in constraining the ages of the igneous and sedimentary protoliths, but is 'blind' to metamorphism at grades lower than granulite. Here U/Th-Pb dating of monazite, a precise chronometer of metamorphic mineral growth, is systematically applied to the Elat schist and unveils the tectono-metamorphic evolution of the Elat basement. Previous U-Pb dating of detrital zircon has shown that the sedimentary protoliths of the Elat schist are the oldest basement components (≥800 Ma), and detailed structural observations of the schists portrayed a complex deformation history including four successive phases (Shimron, 1972). The earliest three phases were defined as ductile and penetrative, but some of the available geochronological data apparently contradict field relations. In-situ analysis of metamorphic monazites by LASS (Laser Ablation Split Stream) involves simultaneous measurement of U/Th-Pb isotope ratios and REE contents in a single 10 μm sized grain or domain, thus allowing determining the age of specific texture and metamorphic assemblage. Monazite dating of the Elat schist yielded two concordant age clusters at 712±6 and 613±5 Ma. The corresponding REE patterns of the dated monazite grains indicate that porphyroblast growth, either garnet or staurolite

  20. Micromechanics of Spray-On Foam Insulation

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Aboudi, Jacob; Arnold, Steven M.; Sullivan, Roy M.

    2007-01-01

    Understanding the thermo-mechanical response of the Space Shuttle External Tank spray-on foam insulation (SOFI) material is critical, to NASA's Return to Flight effort. This closed-cell rigid polymeric foam is used to insulate the metallic Space Shuttle External Tank, which is at cryogenic temperatures immediately prior to and during lift off. The shedding of the SOFI during ascent led to the loss of the Columbia, and eliminating/minimizing foam lass from the tank has become a priority for NASA as it seeks to resume scheduled space shuttle missions. Determining the nature of the SOFI material behavior in response to both thermal and mechanical loading plays an important role as any structural modeling of the shedding phenomenon k predicated on knowledge of the constitutive behavior of the foam. In this paper, the SOFI material has been analyzed using the High-Fidelity Generalized Method of Cells (HFGMC) micromechanics model, which has recently been extended to admit a triply-periodic 3-D repeating unit cell (RUC). Additional theoretical extensions that mere made in order to enable modeling of the closed-cell-foam material include the ability to represent internal boundaries within the RUC (to simulated internal pores) and the ability to impose an internal pressure within the simulated pores. This latter extension is crucial as two sources contribute to significant internal pressure changes within the SOFI pores. First, gas trapped in the pores during the spray process will expand or contract due to temperature changes. Second, the pore pressure will increase due to outgassing of water and other species present in the foam skeleton polymer material. With HFGMC's new pore pressure modeling capabilities, a nonlinear pressure change within the simulated pore can be imposed that accounts for both of these sources, in addition to stmdar&-thermal and mechanical loading; The triply-periodic HFGMC micromechanics model described above was implemented within NASA GRC's MAC

  1. What do large scale studies of medication in schizophrenia add to our management strategies?

    PubMed

    Agius, Mark; Davis, Abigail; Gilhooley, Michael; Chapman, Shelley; Zaman, Rashid

    2010-06-01

    used, which were reflected in their differing rates of efficacy. * CUtLASS This trial allows for less generalisation of its findings to the general population as it makes use a specific sub-population (those switching from one medication to another after a period of treatment). Also some patients were prescribed oral medications and some depot injections - making comparisons difficult due to possible differences in compliance. * EUFEST This trial makes use of discontinuation as an endpoint with the weaknesses we have described. Treatment of first episodes of psychosis is shown to be feasible, but it could not suggest if haloperidol or second generation drugs may be more efficacious. * SOHO - This trial hindered by the observational design of the study and small numbers reaching the primary end point (4%) caution should be exercised in the conclusion that olanzapine is superior to risperidone, quetiapine or typical antipsychotics. There is much information useful for clinical practice to be gathered from the results of these major studies, however, interpretation is hampered by both variations and weakness in study design. On balance it does appear that different antipsychotics possess differing efficacy, but also of relevance to the development of sound clinical guidelines is their differing side effects profile.

  2. Minimum reporting standards for copers in chronic ankle instability research.

    PubMed

    Wikstrom, Erik A; Brown, Cathleen N

    2014-02-01

    Lateral ankle sprains (LASs) are among the most common sports-related injuries and a high percentage of individuals who sprain their ankle go on to develop chronic ankle instability (CAI). The condition of CAI is often classified as having pain, loss of function, and a restriction of, or failure to, return to levels of previous activity. Historically, uninjured healthy controls are used as a comparison group to study the biomechanical and neuromuscular consequences of CAI. However, this model is not ideal to determine why a portion of the population experiencing an ankle sprain does not recover. A more appropriate comparison may be individuals who had an ankle sprain, and thus the exposure, but did not go on to develop CAI (i.e., copers). Thus, the purpose of this review was to determine the existing discrepancies and common standards in definitions of, terminology used for, and the inclusionary/exclusionary criteria used to describe copers within the CAI literature. Multiple databases were searched by keywords and specific authors. Potential studies were screened independently by both authors. Inclusion criteria consisted of an explicit definition of copers and explicit inclusionary/exclusionary criteria. A total of 21 studies were included in the current study and had four outcomes extracted: (1) the definition of copers; (2) the terminology used; (3) specific inclusionary/exclusionary criteria; and (4) injury characteristics of the copers. Based on the included operational definitions, it is recommend that future operational definitions of copers include three key components: (1) an initial LAS; (2) subsequent lack of CAI symptoms (i.e., no complaints of disability or giving way); and (3) a time since injury component. The term coper was overwhelming used within the existing literature (n = 15) and is thus recommended to be used in future studies when describing individuals who have suffered an LAS but failed to develop CAI. Minimal inclusionary criteria should

  3. EDITORIAL: The 24th Nordic Semiconductor Meeting The 24th Nordic Semiconductor Meeting

    NASA Astrophysics Data System (ADS)

    Páll Gunnlaugsson, Haraldur; Nylandsted Larsen, Arne; Uhrenfeldt, Christian

    2012-03-01

    AndersenAalborg University, Aalborg, Denmark Pia BomholtAarhus University, Aarhus, Denmark Hafliði P GíslasonUniversity of Iceland, Reykjavik, Iceland Haraldur Páll GunnlaugssonAarhus University, Aarhus, Denmark John HansenAarhus University, Aarhus, Denmark Britta JohansenAarhus University, Aarhus, Denmark Volodymyr KhranovskyyLinköping University, Linköping, Sweden Arne Nylandsted LarsenAarhus University, Denmark Helge MalmbekkUniversity of Oslo, Oslo, Norway Erik Stensrud MarsteinInstitute for Energy Technology, Kjeller, Norway Antonio MartiUniversidad Politécnica de Madrid, Madrid, Spain Torben MølholtUniversity of Iceland, Reykjavik, Iceland Sveinn ÓlafssonUniversity of Iceland, Reykjavik, Iceland Thomas PedersenTechnical University of Denmark, Kgs. Lyngby, Denmark Thomas Garm PedersenAalborg University, Aalborg, Denmark Dirch Hjorth PetersenTechnical University of Denmark, Kgs. Lyngby, Denmark Vincent QuemenerUniversity of Oslo, Oslo, Norway Henry RadamsonKTH Royal Institute of Technology, Kista, Sweden Bahman RaeissiUniversity of Oslo, Oslo, Norway Jonatan SlotteAalto University, Aalto, Finland Xin SongUniversity of Oslo, Oslo, Norway Einar Örn SveinbjörnssonUniversity of Iceland, Reykjavik, Iceland Mikael SyväjärviLinköping University, Linköping, Sweden Chi Kwong TangUniversity of Oslo, Oslo, Norway Erik V ThomsenTechnical University of Denmark, Kgs. Lyngby, Denmark Christian UhrenfeldtAarhus University, Aarhus, Denmark Hans Ulrik UlriksenAalborg University, Aalborg, Denmark Muhammad UsmanKTH Royal Institute of Technology, Kista, Sweden Lasse VinesUniversity of Oslo, Oslo, Norway Ulrich WahlUnidade de Física e Aceleradores, Sacavém, Portugal Helge WemanNTNU, Trondheim, Norway Gerd WeyerAarhus University, Denmark

  4. Archaeological Geophysics in Israel: Past, Present and Future

    NASA Astrophysics Data System (ADS)

    Eppelbaum, L. V.

    2009-04-01

    et al., 1999; Reeder et al., 2004; Reinhardt et al., 2006; Reich et al., 2003; Ron et al., 2003; Segal et al., 2003; Sternberg and Lass, 2007; Sternberg et al., 1999; Verri et al., 2004; Weiner et al., 1993; Weinstein-Evron et al., 1991, 2003; Weiss et al., 2007; Witten et al., 1994), and (3) future [2010 -]. The past stage with several archaeoseismic reviews and very limited application of geophysical methods was replaced by the present stage with the violent employment of numerous geophysical techniques (first of all, high-precise magnetic survey and GPR). It is supposed that the future stage will be characterized by extensive development of multidiscipline physical-archaeological databases (Eppelbaum et al., 2009b), utilization of supercomputers for 4D monitoring and ancient sites reconstruction (Foster et al., 2001; Pelfer et al., 2004) as well as wide application of geophysical surveys using remote operated vehicles at low altitudes (Eppelbaum, 2008a). REFERENCES Batey, R.A., 1987. Subsurface Interface Radar at Sepphoris, Israel 1985. Journal of Field Archaeology, 14 (1), 1-8. Bauman, P., Parker, D., Coren, A., Freund, R., and Reeder, P., 2005. Archaeological Reconnaissance at Tel Yavne, Israel: 2-D Electrical Imaging and Low Altitude Aerial Photography. CSEG Recorder, No. 6, 28-33. Ben-Dor, E., Portugali, J., Kochavi, M., Shimoni, M., and Vinitzky, L., 1999. Airborne thermal video radiometry and excavation planning at Tel Leviah, Golan Heights, Israel. Journal of Field Archaeology, 26 (2), 117-127. Ben-Menahem, A., 1979. Earthquake catalogue for the Middle East (92 B.C. - 1980 A.D.). Bollettino di Geofisica Teorica ed Applicata, 21 (84), 245-310. Ben-Yosef, E., Tauxe, L., Ronb, H., Agnon, A., Avner, U., Najjar, M., and Levy, T.E., 2008. A new approach for geomagnetic archaeointensity research: insights on ancient metallurgy in the Southern Levant. Journal of Archaeological Science, 25, 2863-2879. Berkovitch, A.L., Eppelbaum, L.V., and Basson, U., 2000