Sample records for jacek flak veikko

  1. Developing a Fly-Away-Kit (FLAK) to Support Hastily Formed Networks (HFN) for Humanitarian Assistance and Disaster Relief (HA/DR)

    DTIC Science & Technology

    2005-06-01

    HFN Components: Reach-Back, Last-Mile, and FLAK .............19 Figure 5. Example of a VSAT solution (from Tachyon , 2004...and IDU (From Tachyon Networks, 2004) ............................................31 Figure 16. IDU...44 Figure 22. Tachyon Auto Deploy ODU and IDU .............................................................44 Figure

  2. The Crystal Structure of GXGD Membrane Protease FlaK

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J Hu; Y Xue; S Lee

    2011-12-31

    The GXGD proteases are polytopic membrane proteins with catalytic activities against membrane-spanning substrates that require a pair of aspartyl residues. Representative members of the family include preflagellin peptidase, type 4 prepilin peptidase, presenilin and signal peptide peptidase. Many GXGD proteases are important in medicine. For example, type 4 prepilin peptidase may contribute to bacterial pathogenesis, and mutations in presenilin are associated with Alzheimer's disease. As yet, there is no atomic-resolution structure in this protease family. Here we report the crystal structure of FlaK, a preflagellin peptidase from Methanococcus maripaludis, solved at 3.6 {angstrom} resolution. The structure contains six transmembrane helices.more » The GXGD motif and a short transmembrane helix, helix 4, are positioned at the centre, surrounded by other transmembrane helices. The crystal structure indicates that the protease must undergo conformational changes to bring the GXGD motif and a second essential aspartyl residue from transmembrane helix 1 into close proximity for catalysis. A comparison of the crystal structure with models of presenilin derived from biochemical analysis reveals three common transmembrane segments that are similarly arranged around the active site. This observation reinforces the idea that the prokaryotic and human proteases are evolutionarily related. The crystal structure presented here provides a framework for understanding the mechanism of the GXGD proteases, and may facilitate the rational design of inhibitors that target specific members of the family.« less

  3. The crystal structure of GXGD membrane protease FlaK

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hu, Jian; Xue, Yi; Lee, Sangwon

    2011-09-20

    The GXGD proteases are polytopic membrane proteins with catalytic activities against membrane-spanning substrates that require a pair of aspartyl residues. Representative members of the family include preflagellin peptidase, type 4 prepilin peptidase, presenilin and signal peptide peptidase. Many GXGD proteases are important in medicine. For example, type 4 prepilin peptidase may contribute to bacterial pathogenesis, and mutations in presenilin are associated with Alzheimer's disease. As yet, there is no atomic-resolution structure in this protease family. Here we report the crystal structure of FlaK, a preflagellin peptidase from Methanococcus maripaludis, solved at 3.6 {angstrom} resolution. The structure contains six transmembrane helices.more » The GXGD motif and a short transmembrane helix, helix 4, are positioned at the centre, surrounded by other transmembrane helices. The crystal structure indicates that the protease must undergo conformational changes to bring the GXGD motif and a second essential aspartyl residue from transmembrane helix 1 into close proximity for catalysis. A comparison of the crystal structure with models of presenilin derived from biochemical analysis reveals three common transmembrane segments that are similarly arranged around the active site. This observation reinforces the idea that the prokaryotic and human proteases are evolutionarily related. The crystal structure presented here provides a framework for understanding the mechanism of the GXGD proteases, and may facilitate the rational design of inhibitors that target specific members of the family.« less

  4. Implementation of a Modular Fly away Kits (FLAK) for C4ISR in order to counter Asymmetric Threats in the Coalition Riverine and Maritime Theatres

    DTIC Science & Technology

    2006-06-01

    integrated scenario tests of the completed FLAK in Chiang Mai , Thailand in May 2006. Measures of Effectiveness and Measures of Performance will be...Royal Thai Air Force Headquarters – Bangkok, Thailand Maritime Intelligence Fusion Center – Alameda, CA IIFC – Chiang Mai , Thailand Figure 22...to the Mae Ngat Dam, 60 kilometers north of Chiang Mai , Thailand was implemented. 2. Network Architecture The network that was designed for

  5. Beveled Femtosecond Laser Astigmatic Keratotomy for the Treatment of High Astigmatism Post–Penetrating Keratoplasty

    PubMed Central

    Cleary, Catherine; Tang, Maolong; Ahmed, Habeeb; Fox, Martin; Huang, David

    2013-01-01

    Purpose To use beveled femtosecond laser astigmatic keratotomy (FLAK) incisions to treat high astigmatism after penetrating keratoplasty. Methods Paired FLAK incisions at a bevel angle of 135 degrees, 65% to 75% depth, and arc lengths of 60 to 90 degrees were performed using a femtosecond laser. One case of perpendicular FLAK was presented for comparison. Vector analysis was used to calculate the changes in astigmatism. Fourier domain optical coherence tomography was used to examine incision morphology. Results Wound gaping requiring suturing was observed in the case of perpendicular FLAK. Six consecutive cases of beveled FLAK were analyzed. Fourier domain optical coherence tomography showed that beveled FLAK caused a mean forward shift of Bowman layer anterior to the incisions of 126 ± 38 μm, with no wound gaping. The mean magnitude of preoperative keratometric astigmatism was 9.8 ± 2.9 diopters (D), and postoperatively it was 4.5 ± 3.2 D (P < 0.05). Uncorrected visual acuity improved from 1.24 ± 0.13 logarithm of the minimum angle of resolution preoperatively to 0.76 ± 0.38 postoperatively (P < 0.05). Best spectacle–corrected visual acuity improved from 0.43 ± 0.33 logarithm of the minimum angle of resolution preoperatively to 0.27 ± 0.24 postoperatively (P = 0.22). Visual results were reduced in 2 patients by cataract progression. Between 1 and 3 months after beveled FLAK, the keratometric cylinder was stable (<1 D change) in 5 of 6 patients, and regressed in 1 patient. No complications occurred. Conclusions Beveled FLAK incisions at varied depth are effective in the management of postkeratoplasty astigmatism. Early postoperative changes stabilized within 1 month in most patients. Further studies are needed to assess long-term outcomes. PMID:22968362

  6. The Antiaircraft Journal. Volume 91, Number 6, November-December 1948

    DTIC Science & Technology

    1948-12-01

    8,000 feet resulted in such heavy flak losses that, as a rule, the Eighth Air Force never thereafter bombed heavily defended targets from low altitude...Jobll B. B. Trussell, Jr 27 OFFICER PROMOTION POLICIES . B)’ Major General Johll E. Dahlquist 31 AIRDROME DEFENSE IN THE ARCTIC. B)’ Lieutellallt...AUTHORS 42 REPORT ON 120MM EQUIPMENT 43 EIGHTH AIR FORCE DEFENSIVE MEASURES AGAINST GERMAi’J’ FLAK 45 Ai"l’TIAIRCRAFT ARTILLERY HAS AN ASSURED PLACE IN

  7. When Research Criticizes an Industry

    ERIC Educational Resources Information Center

    Blumenstyk, Goldie

    2007-01-01

    When Robert W. Van Kirk released a study in January about selenium contamination in trout streams in southeastern Idaho, he expected some flak from the influential phosphate-mining industry. He did not expect to feel pressured by the administration of his own institution, Idaho State University, where he is an associate professor of mathematics.…

  8. Backers of "21st-Century Skills" Take Flak

    ERIC Educational Resources Information Center

    Sawchuk, Stephen

    2009-01-01

    The phrase "21st-century skills" is everywhere in education policy discussions these days, from faculty lounges to the highest echelons of the U.S. education system. Broadly speaking, it refers to a push for schools to teach critical-thinking, analytical, and technology skills, in addition to the "soft skills" of creativity, collaboration, and…

  9. Microbial avirulence determinants: guided missiles or antigenic flak?

    PubMed

    Skamnioti, Paraskevi; Ridout, Christopher J

    2005-09-01

    SUMMARY Avirulence (avr) determinants are incompatibility factors which elicit host plant defence responses in a gene-for-gene manner. They are produced by fungi, bacteria and viruses, and their recognition by resistance genes has been extensively studied for decades. But why should a microbe keep a molecule that allows it to be recognized? One argument is that avr genes perform some essential function and must be kept despite giving the pathogen away. Many bacterial avr determinants have been shown to be effectors, which contribute to virulence and aggressiveness. If this were always the case, mutants lacking these essential molecules would be at a serious disadvantage. Some disadvantage has been shown for a small number, but for the majority there is no effect on virulence. This has been explained by functional redundancy for bacterial and fungal avr determinants, with other molecules compensating for the deletion of these essential genes. However, this argument is counter-intuitive because by definition these individual genes are no longer essential; so why keep them? With increasing numbers of avr genes being identified, efforts to elucidate their function are increasing. In this review, we take stock of the accumulating literature, and consider what the real function of avr determinants might be.

  10. Rhode Island's got the Blues. But the state's Blues plan isn't the only one drawing fire over its reserves, executive perks and compensation.

    PubMed

    Benko, Laura B

    2004-05-17

    It's been a strained few months at Blue Cross and Blue Shield of Rhode Island. Outrage over corporate excess led to a flurry of reforms at the insurer, headed by Chairman Frank Montanaro, left, including banning loans to employees and dropping lavish perks. Other Blues have been catching flak for their burgeoning bottom lines, but executives say they need ample reserves since that's their only capital.

  11. Correlation Between Corneal Button Size and Intraocular Pressure During Femtosecond Laser-Assisted Keratoplasty.

    PubMed

    Choi, Mihyun; Lee, Yong Eun; Whang, Woong-Joo; Yoo, Young-Sik; Na, Kyung-Sun; Joo, Choun-Ki

    2016-03-01

    To evaluate changes in intraocular pressure (IOP) in recipient and donor eyes during femtosecond laser-assisted keratoplasty (FLAK) and to assess for differences in the diameter of trephinated corneal buttons according to changes in pressure. Twenty porcine whole eyes (recipient model) and 20 porcine-corneoscleral rims (donor model) were prepared, and anterior chamber pressures were measured using a fiberoptic sensing device (Opsens, Quebec, Canada) during the femtosecond laser corneal cutting process. To determine the diameter of corneal buttons, 10 porcine whole eyes (recipient model) and 12 corneoscleral rims (donor model) of each baseline IOP were cut with the femtosecond laser programmed to the following pattern: "vertical side cut"; 1200 μm (depth), 8 mm (diameter). Digital photographs were obtained using microscopy and subsequently analyzed. The IOP (mean ± SD) for the recipient model was 10.2 (±0.9) mm Hg at baseline and ranged from 96.6 (±4.5) to ∼138.4 (±3.8) mm Hg during the corneal cutting process. This shows that the maximum IOP during FLAK increased 13.5 times compared with baseline. In the donor model, the mean pressure elevation from baseline artificial anterior chamber (AAC) pressure to corneal cutting was 15.8 (±5.4) mm Hg. This showed a positive correlation with baseline IOP [correlation coefficient (CC) = 0.827, P = 0.006]. As the baseline IOP in the recipient eye increased, trephinated corneal button size was reduced by up to 3.9% in diameter (CC = -0.945, P = 0.015). In addition, in donor eyes, the diameter was decreased by up to 11.7% as the baseline AAC pressure increased (CC = -0.934, P = 0.006). During the FLAK procedure, the IOP increases in both recipient and donor eyes. The diameter of the trephinated donor and recipient corneal buttons was decreased as the initial baseline IOP increased. Ophthalmic surgeons can determine the AAC pressure based on the baseline IOP in the recipient patient.

  12. Conference Proceedings for Optical Fiber Sensors Conference (8th) held in Monterey, California on January 29 - 31 1992

    DTIC Science & Technology

    1992-01-01

    Research Center, East Hartford, CT Program Chair Anthony Dandridge Naval Research Laboratory, Washington, DC PROGRAM COMMnrTEE KIIIl BIetekjaer WAilliam W...Moray Norwegian knst. of Technology, Norway tkited Technologies Research Center, East Hartford, CT Jacek Chrostowski Julchl Noda National Research ...Technology, Boulder, CO Aa .Rgr Shacul Ezekiel *Vngs College, London, United lingdomn MIT, Lexington, MA Pee J. Samson Masamltsu Haruna BHP Central Research

  13. Operationalizing Mobile Applications for Humanitarian Assistance/Disaster Relief Missions

    DTIC Science & Technology

    2014-03-01

    FLAK, equipped with BGAN, WiMAX and meshed Wi-Fi gear. The group also brought power solutions such as solar cells, fuel cells, and wind turbines as...Open data kit sensors : Mobile data collection with wired and wireless sensors . Seattle, WA: Department of Computer Science and Engineering. Retrieved...activities taking place in the society. Over the years, communication has been modified from basic landlines to wireless schemes prevalent today, and

  14. Archie to SAM: A Short Operational History of Ground-Based Air Defense

    DTIC Science & Technology

    2005-08-01

    World War II era. Notes 1. Edward Westermann, Flak: German Anti-Aircraft Defenses 1914–1945 (Lawrence, Kans.: University Press, 2001), 9. 2. Ibid., 10–16...December 1945), 255–56; and Hogg, Anti-Aircraft, 115. 74. Thomas Edwards and Murray Gelster, “The Causes of Bombing Errors as Determined from Analysis of...Tactics over North Vietnam” (thesis, Air Command and Staff College, Maxwell AFB, Ala., 1975), 13, AUL. 21. Giles Van Nederveen, “Sparks over Vietnam: The

  15. Two host cytoplasmic effectors are required for pathogenesis of Phytophthora sojae by suppression of host defenses.

    PubMed

    Liu, Tingli; Ye, Wenwu; Ru, Yanyan; Yang, Xinyu; Gu, Biao; Tao, Kai; Lu, Shan; Dong, Suomeng; Zheng, Xiaobo; Shan, Weixing; Wang, Yuanchao; Dou, Daolong

    2011-01-01

    Phytophthora sojae encodes hundreds of putative host cytoplasmic effectors with conserved FLAK motifs following signal peptides, termed crinkling- and necrosis-inducing proteins (CRN) or Crinkler. Their functions and mechanisms in pathogenesis are mostly unknown. Here, we identify a group of five P. sojae-specific CRN-like genes with high levels of sequence similarity, of which three are putative pseudogenes. Functional analysis shows that the two functional genes encode proteins with predicted nuclear localization signals that induce contrasting responses when expressed in Nicotiana benthamiana and soybean (Glycine max). PsCRN63 induces cell death, while PsCRN115 suppresses cell death elicited by the P. sojae necrosis-inducing protein (PsojNIP) or PsCRN63. Expression of CRN fragments with deleted signal peptides and FLAK motifs demonstrates that the carboxyl-terminal portions of PsCRN63 or PsCRN115 are sufficient for their activities. However, the predicted nuclear localization signal is required for PsCRN63 to induce cell death but not for PsCRN115 to suppress cell death. Furthermore, silencing of the PsCRN63 and PsCRN115 genes in P. sojae stable transformants leads to a reduction of virulence on soybean. Intriguingly, the silenced transformants lose the ability to suppress host cell death and callose deposition on inoculated plants. These results suggest a role for CRN effectors in the suppression of host defense responses.

  16. Sweep Width Determination for HU-25B Airborne Radars: Life Raft and Recreational Boat Targets

    DTIC Science & Technology

    1989-09-01

    in this case ), instead of to multiple parameters of interest. The effects of other parameters cannot be identified or quantified. 2 . The binary...rougher than those represented in the main body of data, averaging 9 to 10 feet (see section 1.3.6). Table 2 -1. Number of Searcher/Target Interactions...1987 experiment. 2 -1 2.2 DETECTION PERFORMANCE Sections 2.2.1 through 2.2.3 present results of the AN/APS-127 FLAR, AN/APS-131 SLAR, and combined FLAK

  17. Strike Rescue - Are We on the Right Path?

    DTIC Science & Technology

    1990-11-16

    Vietnam, a pilot had more to worry about than just enemy SAM’s and flak. More than one POW was bagged by his own weapon system. CDR Jeremiah A. Denton ...Squadron (SOS) based at Eglin AFB in Florida. The MH-60G features an air-to-air refueling probe and auxiliary internal fuel tanks. This allows for 4.5...missions in a contaminated NBC environment. Specifically, let’s consider SC𔄁 missions to rescue "human shields" that Hussein has inserted to protect

  18. More Civilians on the West Point Faculty: Good for the Army, or Not?

    DTIC Science & Technology

    1993-06-05

    31hb) LV~rr.tc h .,C 2•%•- J 1. AGENCY USE ONLY (Leave bd’flak) J2. REPORT DATE I 3. REPORT TYPE AND DATES COVERED 5 June 1993 Master’s Thesis,1 Aug...8217101 ýo J ’: 44SBy Fort Leavenworth, Kansas . 1993 Dist u Approved for public release; distribution is unlimited. MASTER OF MILITARY ART AND SCIENCE...Director, Graduate Degree Philip J . Brookes, Ph.D. Programs The opinions and conclusions expressed herein are those of the student author and do not

  19. The Early Operations of the Eighth Air Force and the Origins of the Combined Bomber Offensive, 17 August 1942 to 10 June 1943

    DTIC Science & Technology

    1946-10-01

    r«»lly *d«qu*t« aMl * *ad it •arletd, «• It i»er», ^ht fomal «atry of tit». &**!•&*«& W«J»*r» imto «»• Wg U*ftt* of »tr»t»gio boabardbMnt. Hum, f«r... thesi soat was the intanaity ao4 aoouracy of the flak which, unlike that previously experienced, was thro»u up in a "predicted barrage1* rather then in...49, 53, 69, 1% ?!, 78, 9^-97, 103, 109, 175-76, 182, 237, 239, 308, 316 (a 30) CO, 16, 81 Hq.,97 Till Fightwr Coad., 34, 46-47, 240, 308 Cft

  20. Lawmakers battle for reform on many fronts.

    PubMed

    Dorr, Robert F

    2003-11-01

    In Washington, much of the attention of the nation's leaders is focused on the economy, on next year's election, and on the war's aftermath in Iraq. Polls show that a restive nation wants more jobs and fewer casualties in the war on terror. In the world of aerospace, few topics seem to be headline-grabbers lately, but the lawmakers are always working on air and space issues--some of them very familiar to Americans. The U.S. program for manned spaceflight remains controversial and a firm date for a return to flight elusive. The little-known air war in Colombia is receiving more attention than many in Washington would like. And the Air Force plan to lease air-refueling tankers continues to draw flak from the Hill.

  1. ARCHIE, FLAK, AAA, AND SAM A Short Operational History of Ground-Based Air Defense

    DTIC Science & Technology

    1988-12-01

    81 44 Nike Ajax...83 45 Nike Hercules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 46 Hawk...German Artillery of World War II (London: Arms and Armour , 1975), 162, 167 ; R. A. Devereux, "German Experience with Antiaircraft Artillery Guns in WWII

  2. Kevlar® as a Potential Accident Radiation Dosimeter for First Responders, Law Enforcement and Military Personnel.

    PubMed

    Romanyukha, Alexander; Trompier, François; Benevides, Luis A

    2016-08-01

    Today the armed forces and law enforcement personnel wear body armor, helmets, and flak jackets composed substantially of Kevlar® fiber to prevent bodily injury or death resulting from physical, ballistic, stab, and slash attacks. Therefore, there is a high probability that during a radiation accident or its aftermath, the Kevlar®-composed body armor will be irradiated. Preliminary study with samples of Kevlar® foundation fabric obtained from body armor used by the U.S. Marine Corps has shown that all samples evaluated demonstrated an EPR signal, and this signal increased with radiation dose. Based on these results, the authors predict that, with individual calibration, exposure at dose above 1 Gy can be reliably detected in Kevlar® samples obtained from body armor. As a result of these measurements, a post-event reconstruction of exposure dose can be obtained by taking various samples throughout the armor body and helmet worn by the same irradiated individual. The doses can be used to create a whole-body dose map that would be of vital importance in a case of a partial body or heterogeneous exposure.

  3. Gene duplication and fragment recombination drive functional diversification of a superfamily of cytoplasmic effectors in Phytophthora sojae.

    PubMed

    Shen, Danyu; Liu, Tingli; Ye, Wenwu; Liu, Li; Liu, Peihan; Wu, Yuren; Wang, Yuanchao; Dou, Daolong

    2013-01-01

    Phytophthora and other oomycetes secrete a large number of putative host cytoplasmic effectors with conserved FLAK motifs following signal peptides, termed crinkling and necrosis inducing proteins (CRN), or Crinkler. Here, we first investigated the evolutionary patterns and mechanisms of CRN effectors in Phytophthora sojae and compared them to two other Phytophthora species. The genes encoding CRN effectors could be divided into 45 orthologous gene groups (OGG), and most OGGs unequally distributed in the three species, in which each underwent large number of gene gains or losses, indicating that the CRN genes expanded after species evolution in Phytophthora and evolved through pathoadaptation. The 134 expanded genes in P. sojae encoded family proteins including 82 functional genes and expressed at higher levels while the other 68 genes encoding orphan proteins were less expressed and contained 50 pseudogenes. Furthermore, we demonstrated that most expanded genes underwent gene duplication or/and fragment recombination. Three different mechanisms that drove gene duplication or recombination were identified. Finally, the expanded CRN effectors exhibited varying pathogenic functions, including induction of programmed cell death (PCD) and suppression of PCD through PAMP-triggered immunity or/and effector-triggered immunity. Overall, these results suggest that gene duplication and fragment recombination may be two mechanisms that drive the expansion and neofunctionalization of the CRN family in P. sojae, which aids in understanding the roles of CRN effectors within each oomycete pathogen.

  4. [Exploration of salt in Poland in the second half of the 18th century].

    PubMed

    Danowska, Ewa

    2014-01-01

    Following the First Partition in 1772, Poland lost the salt mines in Wieliczka, Bochnia and in the territory of Ruthenia to Austria. This was a serious blow to the economy, because since then, it became necessary to import salt, which was primarily taken advantage of by the Royal Prussian Maritime Trading Company (Pruska Kompania Morska) importing it from Austria. King Stanislaw August Poniatowski tried to initiate the exploration and exploitation of salt in the areas where it could be profitable. To this end, he ordered the exploration to Filip Carosi and Stanislaw Okraszewski, among other. The salt-works of the Castellan of Leukow, Jacek Jezierski in the town of Solca, in the Lqczyckie Region, active since 1780, was a private investment. Leopold von Beust's Kompania akcyjna obtained salt from a brine near the town of Busko, and Kompania z Osob Krajowych--from a brine in the town of Raczki nad Pilica. In 1782, the King appointed The Ore Commission (Komisja Kruszcowa), consisted of twelve commissioners, in order to conduct the exploration for minerals, including salt, their extraction and further administration. The Crown Treasury Commission (Komisja Skarbu Koronnego), a magistracy dealing with, among others, the economy of the country in a broad sense, was also involved in the exploration and exploatation of salt. At its command, in the summer of 1788, Tadeusz Czacki made a tour of the Kielce region in search of traces of salt. In view of the important events of the Four-Year Sejm (Sejm Czteroletni) and the subsequent loss of independence, the subject of salt exploration had to be abandoned.

  5. CaFe interstellar clouds

    NASA Astrophysics Data System (ADS)

    Bondar, A.; Kozak, M.; Gnaciński, P.; Galazutdinov, G. A.; Beletsky, Y.; Krełowski, J.

    2007-07-01

    A new kind of interstellar cloud is proposed. These are rare (just a few examples among ~300 lines of sight) objects with the CaI 4227-Å, FeI 3720-Å and 3860-Å lines stronger than those of KI (near 7699 Å) and NaI (near 3302 Å). We propose the name `CaFe' for these clouds. Apparently they occupy different volumes from the well-known interstellar HI clouds where the KI and ultraviolet NaI lines are dominant features. In the CaFe clouds we have not found either detectable molecular features (CH, CN) or diffuse interstellar bands which, as commonly believed, are carried by some complex, organic molecules. We have found the CaFe clouds only along sightlines toward hot, luminous (and thus distant) objects with high rates of mass loss. In principle, the observed gas-phase interstellar abundances reflect the combined effects of the nucleosynthetic history of the material, the depletion of heavy elements into dust grains and the ionization state of these elements which may depend on irradiation by neighbouring stars. Based on data collected using the Maestro spectrograph at the Terskol 2-m telescope, Russia; and on data collected using the ESO Feros spectrograph; and on data obtained from the ESO Science Archive Facility acquired with the UVES spectrograph, Chile. E-mail: `arctur'@rambler.ru (AB); marizak@astri.uni.torun.pl (MK); pg@iftia.univ.gda.pl (PG); gala@boao.re.kr (GAG); ybialets@eso.org (YB); jacek@astri.uni.torun.pl (JK)

  6. Cancer heterogeneity and multilayer spatial evolutionary games.

    PubMed

    Świerniak, Andrzej; Krześlak, Michał

    2016-10-13

    Evolutionary game theory (EGT) has been widely used to simulate tumour processes. In almost all studies on EGT models analysis is limited to two or three phenotypes. Our model contains four main phenotypes. Moreover, in a standard approach only heterogeneity of populations is studied, while cancer cells remain homogeneous. A multilayer approach proposed in this paper enables to study heterogeneity of single cells. In the extended model presented in this paper we consider four strategies (phenotypes) that can arise by mutations. We propose multilayer spatial evolutionary games (MSEG) played on multiple 2D lattices corresponding to the possible phenotypes. It enables simulation and investigation of heterogeneity on the player-level in addition to the population-level. Moreover, it allows to model interactions between arbitrary many phenotypes resulting from the mixture of basic traits. Different equilibrium points and scenarios (monomorphic and polymorphic populations) have been achieved depending on model parameters and the type of played game. However, there is a possibility of stable quadromorphic population in MSEG games for the same set of parameters like for the mean-field game. The model assumes an existence of four possible phenotypes (strategies) in the population of cells that make up tumour. Various parameters and relations between cells lead to complex analysis of this model and give diverse results. One of them is a possibility of stable coexistence of different tumour cells within the population, representing almost arbitrary mixture of the basic phenotypes. This article was reviewed by Tomasz Lipniacki, Urszula Ledzewicz and Jacek Banasiak.

  7. Centrosymmetric molecules as possible carriers of diffuse interstellar bands

    NASA Astrophysics Data System (ADS)

    Kaźmierczak, M.; Schmidt, M. R.; Galazutdinov, G. A.; Musaev, F. A.; Betelesky, Y.; Krełowski, J.

    2010-11-01

    In this paper, we present new data with interstellar C2 (Phillips bands A 1 Πu-X1 Σ+g), from observations made with the Ultraviolet-Visual Echelle Spectrograph of the European Southern Observatory. We have determined the interstellar column densities and excitation temperatures of C2 for nine Galactic lines. For seven of these, C2 has never been observed before, so in this case the still small sample of interstellar clouds (26 lines of sight), where a detailed analysis of C2 excitation has been made, has increased significantly. This paper is a continuation of previous works where interstellar molecules (C2 and diffuse interstellar bands) have been analysed. Because the sample of interstellar clouds with C2 has increased, we can show that the width and shape of the profiles of some diffuse interstellar bands (6196 and 5797 Å) apparently depend on the gas kinetic and rotational temperatures of C2; the profiles are broader because of the higher values of the gas kinetic and rotational temperatures of C2. There are also diffuse interstellar bands (4964 and 5850 Å) for which this effect does not exist. Based on observations made with ESO telescopes at the Paranal Observatory under programme IDs 266.D-5655(A), 67.C-0281(A), 71.C-0513(C), 67.D-0439(A) and 082.C-0566(A) and at La Silla under programme IDs 078.C-0403(A), 076.C-0164(A) and 073.C-0337(A). Also based on observations made with the 1.8-m telescope in South Korea and the 2-m telescope at the International Centre for Astronomical and Medico-Ecological Research, Terskol, Russia. E-mail: kazmierczak@astri.uni.torun.pl (MK); schmidt@ncac.torun.pl (MRS); runizag@gmail.com (GAG); ybialets@eso.org (YB); jacek@astri.uni.torun.pl (JK)

  8. Mining districts in the Carson Sink region, Nevada

    USGS Publications Warehouse

    Schrader, F.

    1947-01-01

    The region lies in an area of primarily sedimentary rocks which are principally Mesozoic and are tilted, folded, and faulted and cut by granular intrusives, and flooded by Tertiary lavas as shown on Figure 4. The Mesozoic sediments were strongly folded and invaded by granular intrusives at or about the time of the intrusion of the great Sierra Nevada batholith. The rocks are exposed chiefly in the mountain ranges and hills.The mountain ranges are mostly fault ranges with much of their structure monoclinical. Faulting in many instances has been prominent since the deposition of the Tertiary lavas and continues down to the present, as shown by fresh scarps and recent earthquake disturbances in the Stillwater and Augusta ranges and in general along the flaks of the various ranges by the tilted attitude of the lava flows and lake beds, and by the older lavas in general being tilted at steeper angles than the overlying lake beds. The faulting may be normal or overthrust.The faulting shown in the various mining districts as Fairview and Wonder may be regarded as indicating that of the region in general.In some parts of the region faulting is so young that it is still shown in the topographic forms as by trunctated gulches in the east base of the Stillwater range in Dixie Valley.As the writer in the present work had but small opportunity to examine the rocks excepting in the various mining districts many of which are located far apart, the accompanying geologic map (Fig. 4) is largely compiled from earlier reports of various authors in order to here present a geologic picture of the region. The portion to the north of Latitude 39°30’ is largely adapted from the 40th Parallel Survey and that to the south of the 39th parallel form the papers and reports by Buwalda, Clark, Merriam, Hill, Spurr, and the unpublished work of H. G. Ferguson of the U. S. Geological Survey on the Hawthorne and Tonopah quadrangles.

  9. Model simulations of dense bottom currents in the Western Baltic Sea

    NASA Astrophysics Data System (ADS)

    Burchard, Hans; Janssen, Frank; Bolding, Karsten; Umlauf, Lars; Rennau, Hannes

    2009-01-01

    Only recently, medium intensity inflow events into the Baltic Sea have gained more awareness because of their potential to ventilate intermediate layers in the Southern Baltic Sea basins. With the present high-resolution model study of the Western Baltic Sea a first attempt is made to obtain model based realistic estimates of turbulent mixing in this area where dense bottom currents resulting from medium intensity inflow events are weakened by turbulent entrainment. The numerical model simulation which is carried out using the General Estuarine Transport Model (GETM) during nine months in 2003 and 2004 is first validated by means of three automatic stations at the Drogden and Darss Sills and in the Arkona Sea. In order to obtain good agreement between observations and model results, the 0.5×0.5 nautical mile bathymetry had to be adjusted in order to account for the fact that even at that scale many relevant topographic features are not resolved. Current velocity, salinity and turbulence observations during a medium intensity inflow event through the Øresund are then compared to the model results. Given the general problems of point to point comparisons between observations and model simulations, the agreement is fairly good with the characteristic features of the inflow event well represented by the model simulations. Two different bulk measures for mixing activity are then introduced, the vertically integrated decay of salinity variance, which is equal to the production of micro-scale salinity variance, and the vertically integrated turbulent salt flux, which is related to an increase of potential energy due to vertical mixing of stably stratified flow. Both measures give qualitatively similar results and identify the Drogden and Darss Sills as well as the Bornholm Channel as mixing hot spots. Further regions of strong mixing are the dense bottom current pathways from these sills into the Arkona Sea, areas around Kriegers Flak (a shoal in the western Arkona Sea

  10. FOREWORD: 7th Symposium on Vacuum-based Science and Technology (SVBST2013)

    NASA Astrophysics Data System (ADS)

    Gulbiński, W.

    2014-11-01

    These are the proceedings of the 7th Symposium on Vacuum based Science and Technology organized in Kołobrzeg (PL) on November 19-21, 2013 by the Institute of Technology and Education, Koszalin University of Technology and the Clausius Tower Society under auspices of the Polish Vacuum Society (PTP) and the German Vacuum Society (DVG) and in collaboration with the BalticNet PlasmaTec and the Society of Vacuum Coaters (SVC). It was accompanied by the 12-th Annual Meeting of the German Vacuum Society. The mission of the Symposium is to provide a forum for presentation and exchange of expertise and research results in the field of vacuum and plasma science. After already six successful meetings organized alternately in Poland and Germany our goal is to continue and foster cooperation within the vacuum and plasma science community. This year, the Rudolf-Jaeckel Prize, awarded by the DVG for outstanding achievements in the field of vacuum based sciences, was presented to Dr Ute Bergner, president of the VACOM Vakuum Komponenten & Messtechnik GmbH and a member of our community. The full-day course organized in the framework of the Educational Program by the Society of Vacuum Coaters (SVC) and entitled: An Introduction to Physical Vapor Deposition (PVD) Processes was held on November 18, 2013 as a satellite event of the Symposium. The instructor was Prof. Ismat Shah from Delaware University (US). The Clausius Session, already traditionally organized during the Symposium was addressed this year to young generation. We invited our young colleagues to attend a series of educational lectures reporting on achievements in graphene science, scanning probe microscopy and plasma science. Lectures were given by: Prof. Jacek Baranowski from the Institute of Electronic Materials Technology in Warsaw, Prof. Teodor Gotszalk from the Wroclaw University of Technology and Prof. Holger Kersten from the Christian Albrechts University in Kiel. The Symposium was accompanied by an industry

  11. Zika in Twitter: Temporal Variations of Locations, Actors, and Concepts.

    PubMed

    Stefanidis, Anthony; Vraga, Emily; Lamprianidis, Georgios; Radzikowski, Jacek; Delamater, Paul L; Jacobsen, Kathryn H; Pfoser, Dieter; Croitoru, Arie; Crooks, Andrew

    2017-04-20

    contributes to advancing our understanding of social media discourse during a public health emergency of international concern. ©Anthony Stefanidis, Emily Vraga, Georgios Lamprianidis, Jacek Radzikowski, Paul L Delamater, Kathryn H Jacobsen, Dieter Pfoser, Arie Croitoru, Andrew Crooks. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 20.04.2017.

  12. USD Catalysis Group for Alternative Energy - Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hoefelmeyer, James

    2014-10-03

    I. Project Summary Catalytic processes are a major technological underpinning of modern society, and are essential to the energy sector in the processing of chemical fuels from natural resources, fine chemicals synthesis, and energy conversion. Advances in catalyst technology are enormously valuable since these lead to reduced chemical waste, reduced energy loss, and reduced costs. New energy technologies, which are critical to future economic growth, are also heavily reliant on catalysts, including fuel cells and photo-electrochemical cells. Currently, the state of South Dakota is underdeveloped in terms of research infrastructure related to catalysis. If South Dakota intends to participate inmore » significant economic growth opportunities that result from advances in catalyst technology, then this area of research needs to be made a high priority for investment. To this end, a focused research effort is proposed in which investigators from The University of South Dakota (USD) and The South Dakota School of Mines and Technology (SDSMT) will contribute to form the South Dakota Catalysis Group (SDCG). The multidisciplinary team of the (SDCG) include: (USD) Dan Engebretson, James Hoefelmeyer, Ranjit Koodali, and Grigoriy Sereda; (SDSMT) Phil Scott Ahrenkiel, Hao Fong, Jan Puszynski, Rajesh Shende, and Jacek Swiatkiewicz. The group is well suited to engage in a collaborative project due to the resources available within the existing programs. Activities within the SDCG will be monitored through an external committee consisting of three distinguished professors in chemistry. The committee will provide expert advice and recommendations to the SDCG. Advisory meetings in which committee members interact with South Dakota investigators will be accompanied by individual oral and poster presentations in a materials and catalysis symposium. The symposium will attract prominent scientists, and will enhance the visibility of research in the state of South Dakota. The SDCG

  13. PREFACE: XX International School on Nuclear Physics, Neutron Physics and Applications (Varna2013)

    NASA Astrophysics Data System (ADS)

    Stoyanov, Chavdar; Dimitrova, Sevdalina

    2014-09-01

    nuclear waste treatment. Nuclear methods for applications. A special session in honor of the late Mario Stoitsov, was also part of the program. Many colleagues of Mario from all over the world came to Varna to pay tribute to this prominent scientist and loyal friend. Several colleagues contributed to the organization of the School. We would like to thank them and especially the Scientific Secretary of the School Dr Elena Stefanova and the members of the Organizing Committee Dr Dimitar Tarpanov and Peter Zivkov for their cordiality and high level assistance. We are also grateful to Dr Jacek Dobaczewski, who reached out to the collaborators of Mario Stoitsov on behalf of the conference. Sofia, 20 March 2014 Co-chair persons of the Organizing Committee Prof Dr Sc Ch Stoyanov Prof Dr Sc S Dimitrova Details of the committees are available in the PDF.

  14. Lost Impacts (Invited)

    NASA Astrophysics Data System (ADS)

    Schultz, P. H.; Stickle, A. M.

    2009-12-01

    The absence of a clearly identified crater (or craters) for the proposed YDB impact has raised questions concerning the reality of such an event. Geologic studies have identified impact deposits well before recognizing a causative crater (e.g., Chicxulub and Chesapeake Bay); some have yet to be discovered (e.g., Australasian tektite strewnfields). The absence of a crater, therefore, cannot be used as an argument against the reality of the YDB impact (and its possible consequences). The study here addresses how a large on-land impact during the late Pleistocene or early Holocene could avoid easy detection today. It does not argue the case for a YDB impact, since such evidence must come from the rock record. During the late Pleistocene, the receding Laurentide ice sheet still covered a significant portion of Canada. While a large (1km) body impacting vertically (90°) would penetrate such a low-impedance ice layer and excavate the substrate, an oblique impact couples more of its energy into the surface layer, thereby partially shielding the substrate. Three approaches address the effectiveness of this flak-jacket effect. First, hypervelocity impact experiments at the NASA Ames Vertical Gun Range investigated the effectiveness of low-impedance layers of different thicknesses for mitigating substrate damage. Second, selected experiments were compared with hydrocode models (see Stickle and Schultz, this volume) and extended to large scales. Third, comparisons were made with relict craters found in eroding sediment and ice covers on Mars. Oblique impacts (30 degrees) into soft particulates (no. 24 sand) covering a solid substrate (aluminum) have no effect on the final crater diameter for layer thicknesses exceeding a projectile diameter and result in only plastic deformation in the substrate. In contrast, a vertical impact requires a surface layer at least 3 times the projectile diameter to achieve the same diameter (with significant substrate damage). Oblique impacts

  15. Correlation of Risk Analysis Method Results with Numerical and Limit Equilibrium Methods in Overall Slope Stability Analysis of Southern Wall of Chadormalu Iron Open Pit Mine-Iran / Korelacja wyników analizy ryzyka z wynikami obliczeń numerycznych oraz wynikami uzyskanymi w oparciu o metodę równowagi granicznej zastosowanych do badania stabilności wyrobiska pochyłego na południowej ścianie odkrywkowej kopalni rud żelaza w chadormalu w Iranie

    NASA Astrophysics Data System (ADS)

    Ahangari, Kaveh; Paji, Arman Gholinezhad; Behdani, Alireza Siami

    2013-06-01

    trzech spośród tych metod: metody numerycznej, równowagi granicznej oraz metody probabilistycznej, do analizy stabilności wyrobiska pochyłego na południowej ścianie kopalni rud żelaza w Chadormalu w Iranie. Oprogramowanie wykorzystane w badaniach analitycznych to pakiet FLAK przy metodzie numerycznej, oprogramowanie SLIDE oraz wykresy kołowe przy metodzie równowagi granicznej oraz jakościowe drzewa określające występowanie uskoków i pół-jakościowe macierze ryzyka przy metodzie probabilistycznej. Wyniki uzyskane w oparciu o trzy wyżej wymienione metody wykazały wystąpienie zawalenia się skał metasomatycznych na poziomie od 1405 do 1525 m. Głównymi czynnikami warunkującymi zawalenie się skał w tym regionie była obecność licznych pęknięć oraz uskoków. Wskaźniki bezpieczeństwa uzyskane przy pomocy metod numerycznych, wykresu kołowego oraz oprogramowanie SLIDE wyniosły kolejno: 1.16, 1.25, 1.27. W odniesieniu do niestabilności w rejonie skał metasomatycznych, aby uczynić tę strefę bardziej stabilną należy uwzględnić takie czynniki jak kąt nachylenia ławy oraz obniżenie wysokości. Analiza przeprowadzona w oparciu o macierze ryzyka wykazała, że strefa ta jest strefą wysokiego ryzyka, zaś wyniki analizy numerycznej oraz wyników uzyskanych przy pomocy metody równowagi granicznej w pełni ten wniosek potwierdziły.

  16. PREFACE: Loops 11: Non-Perturbative / Background Independent Quantum Gravity

    NASA Astrophysics Data System (ADS)

    Mena Marugán, Guillermo A.; Barbero G, J. Fernando; Garay, Luis J.; Villaseñor, Eduardo J. S.; Olmedo, Javier

    2012-05-01

    Netherlands), Jacek Puchta (Centre de Physique Théorique de Luminy, Marseille, France), James Ryan (Albert Einstein Institute, Potsdam, Germany), Lorenzo Sindoni (Albert Einstein Institute, Golm, Germany), David Sloan (Institute for Theoretical Physics, Utrecht University, The Netherlands), Johannes Tambornino (Laboratoire de Physique, ENS Lyon, France), Andreas Thurn (Institute for Theoretical Physics III, FAU Erlangen Nürnberg, Germany), Francesca Vidotto (Laboratoire de Physique Subatomique et de Cosmologie, Grenoble, France), and Matteo Smerlak (Albert Einstein Institute, Golm, Germany). We would like to conclude this preamble by thanking all the attendants of the conference for their high and enthusiastic participation. The presence of a large number of past and present Loop Quantum Gravity practitioners, as well as a significant number of top researchers in other approaches to quantum gravity, provided ample opportunities for fruitful scientific exchanges and a very lively atmosphere. It is encouraging to see that, 25 years after the inception of Loop Quantum Gravity, there is a vibrant young community of researchers entering the field. Let us hope that, with their help, the quantization of general relativity can be successfully accomplished in the near future. The Editors Conference photograph

  17. Editorial: Focus on Dynamics and Thermalization in Isolated Quantum Many-Body Systems

    NASA Astrophysics Data System (ADS)

    Cazalilla, M. A.; Rigol, M.

    2010-05-01

    interaction quenches in the Hubbard model: prethermalization and non-equilibrium dynamics Michael Moeckel and Stefan Kehrein Quantum quenches in integrable field theories Davide Fioretto and Giuseppe Mussardo Dynamical delocalization of Majorana edge states by sweeping across a quantum critical point A Bermudez, L Amico and M A Martin-Delgado Thermometry with spin-dependent lattices D McKay and B DeMarco Near-adiabatic parameter changes in correlated systems: influence of the ramp protocol on the excitation energy Martin Eckstein and Marcus Kollar Sudden change of the thermal contact between two quantum systems J Restrepo and S Camalet Reflection of a Lieb-Liniger wave packet from the hard-wall potential D Jukić and H Buljan Probing interaction-induced ferromagnetism in optical superlattices J von Stecher, E Demler, M D Lukin and A M Rey Sudden interaction quench in the quantum sine-Gordon model Javier Sabio and Stefan Kehrein Dynamics of an inhomogeneous quantum phase transition Jacek Dziarmaga and Marek M Rams