34 CFR 650.3 - What regulations apply to the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false What regulations apply to the Jacob K. Javits... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM General § 650.3 What regulations apply to the Jacob K. Javits Fellowship Program? The following...

34 CFR 650.4 - What definitions apply to the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What definitions apply to the Jacob K. Javits... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM General § 650.4 What definitions apply to the Jacob K. Javits Fellowship Program? The following...

34 CFR 650.3 - What regulations apply to the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What regulations apply to the Jacob K. Javits... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM General § 650.3 What regulations apply to the Jacob K. Javits Fellowship Program? The following...

34 CFR 650.4 - What definitions apply to the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false What definitions apply to the Jacob K. Javits... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM General § 650.4 What definitions apply to the Jacob K. Javits Fellowship Program? The following...

34 CFR 650.3 - What regulations apply to the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false What regulations apply to the Jacob K. Javits... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM General § 650.3 What regulations apply to the Jacob K. Javits Fellowship Program? The following...

34 CFR 650.4 - What definitions apply to the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the Jacob K. Javits... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM General § 650.4 What definitions apply to the Jacob K. Javits Fellowship Program? The following...

34 CFR 650.4 - What definitions apply to the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false What definitions apply to the Jacob K. Javits... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM General § 650.4 What definitions apply to the Jacob K. Javits Fellowship Program? The following...

Biography for Michael Rossol | NREL

Science.gov Websites

Biography for Michael Rossol Michael Rossol Michael Rossol Resource Data Scientist Michael.Rossol @nrel.gov | 303-275-3680 Michael Rossol is a member of the Systems Modeling team within the Systems Modeling

Reply to Jackson, O'Keefe, and Jacobs.

ERIC Educational Resources Information Center

Morley, Donald Dean

1988-01-01

Replies to Sally Jackson, Daniel O'Keefe, and Scott Jacobs' article (same issue), maintaining that randomness requirements can not be relaxed for generalizing from message samples, since systematic samples are not truly random. (MS)

Dr. Jacob Cohen presents the H. Julian Allen award to Anthony Colaprete.

NASA Image and Video Library

2017-03-16

Dr. Jacob Cohen Director Office of Chief Scientist with Dr. Anthony Colaprete recipient of the H. Julian Allen Award In recognition as co-author of the outstanding scientific paper entitled "Detection of Water in the LCROSS Ejecta Pluma." Shown here Dr. Jacob Cohen presents the H. Julian Allen award to Anthony Colaprete.

Maniac Talk - Michael Mishchenko

NASA Image and Video Library

2015-01-26

Michael Mishchenko Maniac Lecture, January 26, 2015 NASA climate scientist Dr. Michael I. Mishchenko presented a Maniac Talk entitled "How much first-principle physics do we need in remote-sensing and atmospheric-radiation research." Michael explained his skepticism and how it has shaped his contributions to the disciplines of electromagnetic scattering, radiative transfer, and remote sensing, which have found widespread use.

Writing with Light: Jacob Riis's Ambivalent Exposures

ERIC Educational Resources Information Center

Carter, Christopher

2008-01-01

The current interest in multimodal rhetoric was anticipated by Jacob Riis's social documentary texts and presentations during the late nineteenth and early twentieth centuries. In contrast with the socialist urban critiques presented by Friedrich Engels, Riis's work demonstrated profound ambivalence toward the city's poor. While calling for reform…

Corner Office Interview: Gates Foundation's Deborah Jacobs

ERIC Educational Resources Information Center

Miller, Rebecca

2010-01-01

U.S. libraries gave the world a top talent when Deborah Jacobs left her transformational role as City Librarian of Seattle in 2008 to head the Bill & Melinda Gates Foundation's Global Libraries program, the international sibling to the U.S. Libraries program. The initiative fosters national-scale projects with grantees in transitioning countries…

Program to analyze aquifer test data and check for validity with the jacob method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, M.S.

1993-01-01

The Jacob straight-line method of aquifer analysis deals with the late-time data and small radius of the Theis type curve which plot as a straight line if the drawdown data are plotted on an arithmetic scale and the time data on a logarithmic (base 10) scale. Correct analysis with the Jacob method normally assumes that (1) the data lie on a straight line, (2) the value of the dimensionless time factor is less than 0.01, and (3) the site's hydrogeology conforms to the method's assumptions and limiting conditions. Items 1 and 2 are usually considered for the Jacob method, butmore » item 3 is often ignored, which can lead to incorrect calculations of aquifer parameters. A BASIC computer program was developed to analyze aquifer test data with the Jacob method to test the validity of its use. Aquifer test data are entered into the program and manipulated so that a slope and time intercept of the straight line drawn through the data (excluding early-time and late-time data) can be used to calculate transmissivity and storage coefficient. Late-time data are excluded to eliminate the effects of positive and negative boundaries. The time-drawdown data then are converted into dimensionless units to determine if the Jacob method's assumptions are valid for the hydrogeologic conditions under which the test was conducted.« less

Michael E. Himmel | NREL

Science.gov Websites

E. Himmel Photo of Michael E. Himmel Michael Himmel Senior Research Fellow I-Molecular Biology ;Towards a molecular-level theory of carbohydrate processivity," Curr. Opinion Biotechnol. (2014 University, Department of Biochem. & Molecular Biol., Distinguished Alumnus (2014) Battelle Memorial

"Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacob, Robert

Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

"Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

ScienceCinema

Jacob, Robert

2018-02-07

Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

"Jacob Have I Loved." Learning Page Lesson Plan.

ERIC Educational Resources Information Center

Isaacs, Kathy

In this middle school social studies and literature lesson plan, pictures from "America from the Great Depression to World War II" in the American Memory collection provide visual images to introduce and spark curiosity about "Jacob Have I Loved" by Katherine Paterson, a novel about jealousy set on an island in the Chesapeake…

The Most Abundant Glycoprotein of Amebic Cyst Walls (Jacob) Is a Lectin with Five Cys-Rich, Chitin-Binding Domains

PubMed Central

Frisardi, Marta; Ghosh, Sudip K.; Field, Jessica; Van Dellen, Katrina; Rogers, Rick; Robbins, Phillips; Samuelson, John

2000-01-01

The infectious stage of amebae is the chitin-walled cyst, which is resistant to stomach acids. In this study an extraordinarily abundant, encystation-specific glycoprotein (Jacob) was identified on two-dimensional protein gels of cyst walls purified from Entamoeba invadens. Jacob, which was acidic and had an apparent molecular mass of ∼100 kDa, contained sugars that bound to concanavalin A and ricin. The jacob gene encoded a 45-kDa protein with a ladder-like series of five Cys-rich domains. These Cys-rich domains were reminiscent of but not homologous to the Cys-rich chitin-binding domains of insect chitinases and peritrophic matrix proteins that surround the food bolus in the insect gut. Jacob bound purified chitin and chitin remaining in sodium dodecyl sulfate-treated cyst walls. Conversely, the E. histolytica plasma membrane Gal/GalNAc lectin bound sugars of intact cyst walls and purified Jacob. In the presence of galactose, E. invadens formed wall-less cysts, which were quadranucleate and contained Jacob and chitinase (another encystation-specific protein) in secretory vesicles. A galactose lectin was found to be present on the surface of wall-less cysts, which phagocytosed bacteria and mucin-coated beads. These results suggest that the E. invadens cyst wall forms when the plasma membrane galactose lectin binds sugars on Jacob, which in turn binds chitin via its five chitin-binding domains. PMID:10858239

Pathology of GM2 gangliosidosis in Jacob sheep.

PubMed

Porter, B F; Lewis, B C; Edwards, J F; Alroy, J; Zeng, B J; Torres, P A; Bretzlaff, K N; Kolodny, E H

2011-07-01

The G(M2) gangliosidoses are a group of lysosomal storage diseases caused by defects in the genes coding for the enzyme hexosaminidase or the G(M2) activator protein. Four Jacob sheep from the same farm were examined over a 3-year period for a progressive neurologic disease. Two lambs were 6-month-old intact males and 2 were 8-month-old females. Clinical findings included ataxia in all 4 limbs, proprioceptive deficits, and cortical blindness. At necropsy, the nervous system appeared grossly normal. Histologically, most neurons within the brain, spinal cord, and peripheral ganglia were enlarged, and the cytoplasm was distended by foamy to granular material that stained positively with Luxol fast blue and Sudan black B stains. Other neuropathologic findings included widespread astrocytosis, microgliosis, and scattered spheroids. Electron microscopy revealed membranous cytoplasmic bodies within the cytoplasm of neurons. Biochemical and molecular genetic studies confirmed the diagnosis of G(M2) gangliosidosis. This form of G(M2) gangliosidosis in Jacob sheep is very similar to human Tay-Sachs disease and is potentially a useful animal model. © The Authors 2011

Joseph Jacobs: Apprentice to Crawford W. Long in Athens, GA; Pharmacist and Retailer of Soda Fountain Beverages in Atlanta, GA.

PubMed

Haridas, Rajesh P

2018-01-01

In the 1870s, Joseph Jacobs was employed as an apprentice in the Longs and Billups pharmacy in Athens, GA. Jacobs later established a chain of pharmacies in Atlanta, GA. Coca-Cola was first sold to the public on May 8, 1886, at Jacobs' Pharmacy in the Five Points district of Atlanta, GA. The soda fountain in Jacobs' Pharmacy was owned by Willis E. Venable, who was related to James M. Venable, the first patient etherized by Crawford Long in Jefferson, GA. Copyright © 2018 Elsevier Inc. All rights reserved.

73. TILE WORKS FROM SOUTHEAST, c. 1920. JACOB FRANK COLLECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

73. TILE WORKS FROM SOUTHEAST, c. 1920. JACOB FRANK COLLECTION (MISC 319), SL/BCHS. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

72. TILE WORKS FROM SOUTH, c. 1925. JACOB FRANK COLLECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

72. TILE WORKS FROM SOUTH, c. 1925. JACOB FRANK COLLECTION (MSC 319I. SL/BCHS. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

Errant life, molecular biology, and biopower: Canguilhem, Jacob, and Foucault.

PubMed

Talcott, Samuel

2014-01-01

This paper considers the theoretical circumstances that urged Michel Foucault to analyse modern societies in terms of biopower. Georges Canguilhem's account of the relations between science and the living forms an essential starting point for Foucault's own later explorations, though the challenges posed by the molecular revolution in biology and François Jacob's history of it allowed Foucault to extend and transform Canguilhem's philosophy of error. Using archival research into his 1955-1956 course on "Science and Error," I show that, for Canguilhem, it is inauthentic to treat a living being as an error, even if living things are capable of making errors in the domain of knowledge. The emergent molecular biology in the 1960s posed a grave challenge, however, since it suggested that individuals could indeed be errors of genetic reproduction. The paper discusses how Canguilhem and Foucault each responded to this by examining, among other texts, their respective reviews of Jacob's The Logic of the Living. For Canguilhem this was an opportunity to reaffirm the creativity of life in the living individual, which is not a thing to be evaluated, but the source of values. For Foucault, drawing on Jacob's work, this was the opportunity to develop a transformed account of valuation by posing biopower as the DNA of society. Despite their disagreements, the paper examines these three authors as different iterations of a historical epistemology attuned to errancy, error, and experimentation.

Jack Michael's Motivation

ERIC Educational Resources Information Center

Miguel, Caio F.

2013-01-01

Among many of Jack Michael's contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of "motivating operation" (MO) by outlining its development from Skinner's (1938) notion of "drive." Conceptually, Michael's term helped us change our focus on…

Jacob Lawrence's "The Migration Series": Art as Narrative History

ERIC Educational Resources Information Center

Laney, James D.

2007-01-01

Because art is a reflection of cultural heritage, a natural affinity exists between art and social studies. In Jacob Lawrence's "The Migration Series," art serves as narrative history, with visual images telling the story of the Great Migration, a movement of African American people from the South to the North around World War I. Social studies…

Interview with J. Michael Thompson

ERIC Educational Resources Information Center

Randall, Mary Elisabeth

2004-01-01

J. Michael Thompson is the Vice Provost for Enrollment Management and Dean of Admission and Financial Aid at the University of Southern California. J. Michael has worked in higher education for more than 30 years in a variety of roles at small private and mid-sized and large public universities, and now at USC, a large private university. He has…

"[No] doctor but my master": Health reform and antislavery rhetoric in Harriet Jacobs's Incidents in the life of a slave girl.

PubMed

Berry, Sarah L

2014-03-01

This essay examines Harriet Jacobs's Incidents in the Life of a Slave Girl (1861) in light of new archival findings on the medical practices of Dr. James Norcom (Dr. Flint in the narrative). While critics have sharply defined the feminist politics of Jacobs's sexual victimization and resistance, they have overlooked her medical experience in slavery and her participation in reform after escape. I argue that Jacobs uses the rhetoric of a woman-led health reform movement underway during the 1850s to persuade her readers to end slavery. This essay reconstructs both contexts, revealing that Jacobs links enslaved women's physical and sexual vulnerability with her female readers' fears of male doctors' threats to modesty and of their standard bleed-and-purge treatments. Jacobs illustrates that slavery damages women's health as much as heroic medicine, and thus merits the political activism of her readers. Specifically, Jacobs dramatizes her conflicts with the rapacious physician-master at moments that are crucial to women's health: marriage, pregnancy, childbirth, and motherhood. Ultimately, this essay advances a new understanding of the role of health reform in social change: it galvanized other movements such as women's rights and abolition, particularly around issues of bodily autonomy for women and African Americans.

Maniac Talk - Michael Kurylo

NASA Image and Video Library

2016-11-16

Michael Kurylo Maniac Lecture, November 16, 2016 NASA climate scientist Michael Kurylo presented a Maniac lecture entitled, "An Uncharted Journey: How I Became an Atmospheric Scientist Rather than a Cowboy or a Farmer." Mike described the path that took him from post-WW II housing projects to and through a rural Connecticut neighborhood, how he became convinced about the unrealistic nature of some early naive career dreams, and how he eventually arrived at a career in atmospheric science (research and program management, and their interface with international environmental policy).

34 CFR 650.1 - What is the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., financial need, and exceptional promise, for study at the doctoral level in selected fields of the arts, humanities, and social sciences. (b) Students awarded fellowships under this program are called Jacob K...

34 CFR 650.1 - What is the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., financial need, and exceptional promise, for study at the doctoral level in selected fields of the arts, humanities, and social sciences. (b) Students awarded fellowships under this program are called Jacob K...

34 CFR 650.1 - What is the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., financial need, and exceptional promise, for study at the doctoral level in selected fields of the arts, humanities, and social sciences. (b) Students awarded fellowships under this program are called Jacob K...

34 CFR 650.1 - What is the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., financial need, and exceptional promise, for study at the doctoral level in selected fields of the arts, humanities, and social sciences. (b) Students awarded fellowships under this program are called Jacob K...

34 CFR 650.1 - What is the Jacob K. Javits Fellowship Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., financial need, and exceptional promise, for study at the doctoral level in selected fields of the arts, humanities, and social sciences. (b) Students awarded fellowships under this program are called Jacob K...

Method for promoting Michael addition reactions

DOEpatents

Shah, Pankaj V.; Vietti, David E.; Whitman, David William

2010-09-21

Homogeneously dispersed solid reaction promoters having an average particle size from 0.01 .mu.m to 500 .mu.m are disclosed for preparing curable mixtures of at least one Michael donor and at least one Michael acceptor. The resulting curable mixtures are useful as coatings, adhesives, sealants and elastomers.

Michael J. Fox: Spurring Research on Parkinson's

MedlinePlus

... on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past Issues / Winter 2014 Table of ... founded the Michael J. Fox Foundation for Parkinson's Research in the year 2000. Photo courtesy of Shutterstock " ...

Michael Lawson | NREL

Science.gov Websites

NREL's Ocean Energy team, Dr. Michael Lawson focuses on the areas of wave and water current energy goal of developing an open source design and analysis tool for wave energy conversion (WEC) devices

Current of interacting particles inside a channel of exponential cavities: Application of a modified Fick-Jacobs equation.

PubMed

Suárez, G; Hoyuelos, M; Mártin, H

2016-06-01

Recently a nonlinear Fick-Jacobs equation has been proposed for the description of transport and diffusion of particles interacting through a hard-core potential in tubes or channels of varying cross section [Suárez et al., Phys. Rev. E 91, 012135 (2015)]PLEEE81539-375510.1103/PhysRevE.91.012135. Here we focus on the analysis of the current and mobility when the channel is composed by a chain of asymmetric cavities and a force is applied in one or the opposite direction, for both interacting and noninteracting particles, and compare analytical and Monte Carlo simulation results. We consider a cavity with a shape given by exponential functions; the linear Fick-Jacobs equation for noninteracting particles can be exactly solved in this case. The results of the current difference (when a force is applied in opposite directions) are more accurate for the modified Fick-Jacobs equation for particles with hard-core interaction than for noninteracting ones.

Adjustment of Jacobs' formulation to the case of Mercury

NASA Astrophysics Data System (ADS)

Chiappini, M.; de Santis, A.

1991-04-01

Magnetic investigations play an important role in studies on the constitution of planetary interiors. One of these techniques (the so-called Jacobs' formulation), appropriately modified, has been applied to the case of Mercury. According to the results found, the planet, supposed to be divided internally as the earth (crust-mantle-core), would have a core/planet volume ratio of 28 percent, much greater than the earth's core percentage (16 percent). This result is in agreement with previous work which used other independent methods.

19. WHEELPIT AREA OF 1814 MILL WHERE JACOB PERKINS BREASTWHEEL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. WHEELPIT AREA OF 1814 MILL WHERE JACOB PERKINS BREASTWHEEL WAS INSTALLED AND CONTROLLED BY PAUL MOODY FLYBALL GOVERNOR, LOOKING NORTH, WITH WEST (UPSTREAM) WALL AT LEFT. EXTRA HEAVY LONGITUDINAL BEAMS ORIGINALLY SPANNED WHEELPIT AREA WITHOUT INTERNAL SUPPORTS (METAL COLUMNS IN PHOTO ARE A RECENT ADDITION). EVIDENCE OF HEADRACE ENTRANCE ARCH HAS BEEN OBLITERATED BY CONCRETE RETAINING WALL AT REAR. - Boston Manufacturing Company, 144-190 Moody Street, Waltham, Middlesex County, MA

78 FR 48773 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... HUMBERTO CASANOVA DAWN ELIZABETH CASTILLO CHRISTINE WYSS MARTINEZ CAULFIELD DANA MINET CHAMBERLAIN... JACOB MICHAEL NAFZIGER WILLIAM J NAIR DEEPAK DIVAKARAN NEESER IRENE SYLVIA NEILSEN GREGAR JACK NELSON...

Jacob Hemet. Dentist to royalty and entrepreneur extraordinaire.

PubMed

Ring, Malvin E

2006-11-01

One of the most prominent dentists in late-18th century London was Jacob Hemet, member of a long family of dentists. He was appointed royal dentist to Queen Charlotte, wife of George the Third, and to George's favorite daughter, Amelia, and the Prince of Wales. He advertised widely, both in this country and in several European countries, including his native France. However, what makes him noteworthy is the fact that he was the very first person to patent a dentifrice and the first to use marketing techniques similar to those used by the foremost toothpaste manufacturers of today.

Michael Faraday's Bicentenary.

ERIC Educational Resources Information Center

Williams, L. Pearce; And Others

1991-01-01

Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

Teaching for Transformation: Promoting Social Justice through Teaching: Interview with George Jacobs

ERIC Educational Resources Information Center

Yeo, Marie

2017-01-01

George Jacobs has taught English as a Second Language (ESL) and Teacher Education in many countries, including the US, China and Thailand. Since 1993, he has taught in Singapore, teaching for institutions including SEAMEO Regional Language Centre, Ministry of Education, and the National Institute of Education. He has also been teaching Writing at…

Goodbye Michael Gove

ERIC Educational Resources Information Center

Bassey, Michael

2014-01-01

Michael Gove was Secretary of State for Education from May 2010 to July 2014 when the Prime Minister sacked him. With strong opinions arising from his own life experiences and outstanding energy for reform, but severely limited understanding of education and a refusal to consult teachers and other professionals, he imposed half-baked ideas on the…

Naval Aviation Costs: Targeting Operations and Support

DTIC Science & Technology

2013-12-01

Brian Jacobs n Cmdr. Craig Owen Aubrey Dennis n Michael Berkin n Roy Lancaster n Tim Simpson n Duane Mallicoat Farmer, AIR-6.0B, is the...Department. Jacobs , AIR-6.7B, is the military director, Logistics and Maintenance Planning Department. Owen is the COMFRC Produc- tion director. Dennis...Board Extended Members Vice Adm. McCoy , NAVSEA Vice Adm. Van Buskirk, CNP Lt. Gen. Ronling, MARFORPAC Lt. Gen. Paxton, MARFORCOM

Michael J. Meaney: Award for Distinguished Scientific Contributions

ERIC Educational Resources Information Center

American Psychologist, 2012

2012-01-01

Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…

A high-precision Jacob's staff with improved spatial accuracy and laser sighting capability

NASA Astrophysics Data System (ADS)

Patacci, Marco

2016-04-01

A new Jacob's staff design incorporating a 3D positioning stage and a laser sighting stage is described. The first combines a compass and a circular spirit level on a movable bracket and the second introduces a laser able to slide vertically and rotate on a plane parallel to bedding. The new design allows greater precision in stratigraphic thickness measurement while restricting the cost and maintaining speed of measurement to levels similar to those of a traditional Jacob's staff. Greater precision is achieved as a result of: a) improved 3D positioning of the rod through the use of the integrated compass and spirit level holder; b) more accurate sighting of geological surfaces by tracing with height adjustable rotatable laser; c) reduced error when shifting the trace of the log laterally (i.e. away from the dip direction) within the trace of the laser plane, and d) improved measurement of bedding dip and direction necessary to orientate the Jacob's staff, using the rotatable laser. The new laser holder design can also be used to verify parallelism of a geological surface with structural dip by creating a visual planar datum in the field and thus allowing determination of surfaces which cut the bedding at an angle (e.g., clinoforms, levees, erosion surfaces, amalgamation surfaces, etc.). Stratigraphic thickness measurements and estimates of measurement uncertainty are valuable to many applications of sedimentology and stratigraphy at different scales (e.g., bed statistics, reconstruction of palaeotopographies, depositional processes at bed scale, architectural element analysis), especially when a quantitative approach is applied to the analysis of the data; the ability to collect larger data sets with improved precision will increase the quality of such studies.

Michael Griffin Senate Hearing

NASA Image and Video Library

2005-05-17

NASA Administrator Dr. Michael Griffin speaks in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

OBITUARY: Maurice Jacob (1933 2007)

NASA Astrophysics Data System (ADS)

Quercigh, Emanuele; Šándor, Ladislav

2008-04-01

Maurice Jacob passed away on 2 May 2007. With his death, we have lost one of the founding fathers of the ultra-relativistic heavy ion programme. His interest in high-energy nuclear physics started in 1981 when alpha alpha collisions could first be studied in the CERN ISR. An enthusiastic supporter of ion beam experiments at CERN, Maurice was at the origin of the 1982 Quark Matter meeting in Bielefeld [1] which brought together more than 100 participants from both sides of the Atlantic, showing a good enthusiastic constituency for such research. There were twice as many the following year at Brookhaven. Finally in the mid-eighties, a heavy ion programme was approved both at CERN and at Brookhaven involving as many nuclear as particle physicists. It was the start of a fruitful interdisciplinary collaboration which is nowadays continuing both at RHIC and at LHC. Maurice followed actively the development of this field, reporting at a number of conferences and meetings (Les Arcs, Bielefeld, Beijing, Brookhaven, Lenox, Singapore, Taormina,...). This activity culminated in 2000, when Maurice, together with Ulrich Heinz, summarized the main results of the CERN SPS heavy-ion experiments and the evidence was obtained for a new state of matter [2]. Maurice was a brilliant theoretical physicist. His many contributions have been summarized in a recent article in the CERN Courier by two leading CERN theorists, John Ellis and Andre Martin [3]. The following is an excerpt from their article: `He began his research career at Saclay and, while still a PhD student, he continued brilliantly during a stay at Brookhaven. It was there in 1959 that Maurice, together with Giancarlo Wick, developed the helicity amplitude formalism that is the basis of many modern theoretical calculations. Maurice obtained his PhD in 1961 and, after a stay at Caltech, returned to Saclay. A second American foray was to SLAC, where he and Sam Berman made the crucial observation that the point-like structures

4. Photocopy of inkandwatercolor drawing (from St. Michael's Church) Rambusch, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of ink-and-watercolor drawing (from St. Michael's Church) Rambusch, illustrator ca. 1932-37 INTERIOR, LOOKING NORTHEAST - St. Michael's Catholic Church, 519 East Third Street, Madison, Jefferson County, IN

Michael Griffin Senate Hearing

NASA Image and Video Library

2005-05-17

NASA Administrator Dr. Michael Griffin is seen during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

Michael Griffin Senate Hearing

NASA Image and Video Library

2005-05-17

NASA Administrator Dr. Michael Griffin smiles during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

Michael Griffin Senate Hearing

NASA Image and Video Library

2005-05-17

NASA Administrator Dr. Michael Griffin delivers a statement during testimony in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

Doing It All: Michael Sullivan--Weeks Public Library, NH

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

Michael Sullivan is a juggler--not a metaphorical one, a real one. He's also a library director, storyteller, competitive chess player, poet, speaker, and former children's librarian who continues to work with the kids in his community. This article summarizes the accomplishments and work of Michael Sullivan.

76 FR 10352 - Keyser, Michael J.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6495-000] Keyser, Michael J.; Notice of Filing Take notice that on February 15, 2011, Michael J. Keyser submitted for filing, an application for authority to hold interlocking positions, pursuant to section 305(b) of the...

Language and Intercultural Education: An Interview with Michael Byram

ERIC Educational Resources Information Center

Porto, Melina

2013-01-01

This article reports an interview with Michael Byram, Professor Emeritus, University of Durham in the United Kingdom, during his visit to Argentina in September 2011. Michael Byram is one of the main international referents in intercultural education. The interview addresses issues such as language education, intercultural and citizenship…

Michael Griffin Senate Hearing

NASA Image and Video Library

2005-05-17

NASA Administrator Dr. Michael Griffin is seen prior to his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

Michael Griffin Senate Hearing

NASA Image and Video Library

2005-05-17

Senator Trent Lott, R-Miss., questions NASA Administrator Dr. Michael Griffin during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

Michael Faraday vs. the Spiritualists

NASA Astrophysics Data System (ADS)

Hirshfeld, Alan

2006-12-01

In the 1850s, renowned physicist Michael Faraday launched a public campaign against pseudoscience and spiritualism, which were rampant in England at the time. Faraday objected especially to claims that electrical or magnetic forces were responsible for paranormal phenomena, such as table-spinning and communication with the dead. Using scientific methods, Faraday unmasked the deceptions of spiritualists, clairvoyants and mediums and also laid bare the credulity of a public ill-educated in science. Despite his efforts, Victorian society's fascination with the paranormal swelled. Faraday's debacle anticipates current controversies about public science education and the interface between science and religion. This episode is one of many described in the new biography, The Electric Life of Michael Faraday (Walker & Co.), which chronicles Faraday's discoveries and his unlikely rise from poverty to the pinnacle of the English science establishment.

A Marriage of Minds: James R. Jacobs & Shinjoung Yeo Univ. of California-San Diego

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

Their personalities and backgrounds are very different, but James R. Jacobs and Shinjoung Yeo are passionate about the same causes: librarianship, open government, and empowerment through information. They balance each other. Yeo is focused, realistic, critical, and an excellent researcher. Her superhero alter ego is Wet Blanket Woman, able to…

Q&A: Michael Honey

ERIC Educational Resources Information Center

Helicher, Karl

2007-01-01

The mid-1960s saw civil rights victories in Congress during Lyndon B. Johnson's presidency. In "Going Down Jericho Road," Michael Honey wrote how Martin Luther King Jr.'s final focus showed that the struggle for black and working class parity continued. The 1968 Memphis sanitation workers strike was a gritty struggle won in the streets by a host…

Michael Griffin Senate Hearing

NASA Image and Video Library

2005-05-17

U.S. Senator Bill Nelson. R-Fla., questions NASA Administrator Dr. Michael Griffin during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

Michael Young and the Curriculum Field in South Africa

ERIC Educational Resources Information Center

Hoadley, Ursula

2015-01-01

The paper addresses the question of what we should make of Michael Young's recent work with respect to curriculum theory by considering the particular case of South African curriculum reform. The paper thus traces two trajectories: the evolution of Michael Young's ideas over time and South African curriculum reform in the post-apartheid period.…

Paul Dirac

NASA Astrophysics Data System (ADS)

Pais, Abraham; Jacob, Maurice; Olive, David I.; Atiyah, Michael F.

1998-02-01

Preface Peter Goddard; Dirac memorial address Stephen Hawking; 1. Paul Dirac: aspects of his life and work Abraham Pais; 2. Antimatter Maurice Jacob; 3. The monopole David Olive; 4. The Dirac equation and geometry Michael F. Atiyah.

Paul Dirac

NASA Astrophysics Data System (ADS)

Pais, Abraham; Jacob, Maurice; Olive, David I.; Atiyah, Michael F.

2005-09-01

Preface Peter Goddard; Dirac memorial address Stephen Hawking; 1. Paul Dirac: aspects of his life and work Abraham Pais; 2. Antimatter Maurice Jacob; 3. The monopole David Olive; 4. The Dirac equation and geometry Michael F. Atiyah.

Michael Griffin Oath Of Office

NASA Image and Video Library

2005-04-14

John H. Marburger, Science Adviser to the President and Director of the Office of Science and Technology Policy (OSTP), left, shakes hands with NASA Administrator Michael Griffin following his swearing-in, Thursday, April 14, 2005, in Washington. Photo Credit: (NASA/Renee Bouchard)

Michael Griffin House Science Committee Hearing

NASA Image and Video Library

2005-06-27

NASA Administrator Michael Griffin prepares to testify at a hearing before the House Science Committee, Tuesday, June 28, 2005, Rayburn House Office building, Washington. Photo Credit: (NASA/Bill Ingalls)

Michael Tomasello: Award for Distinguished Scientific Contributions.

PubMed

2015-11-01

The APA Awards for Distinguished Scientific Contributions are presented to persons who, in the opinion of the Committee on Scientific Awards, have made distinguished theoretical or empirical contributions to basic research in psychology. One of the 2015 award winners is Michael Tomasello, who received this award for "outstanding empirical and theoretical contributions to understanding what makes the human mind unique. Michael Tomasello's pioneering research on the origins of social cognition has led to revolutionary insights in both developmental psychology and primate cognition." Tomasello's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

Michael Griffin House Science Committee Hearing

NASA Image and Video Library

2005-06-27

Rep. Bart Gordon, D-TN., questions NASA Administrator Michael Griffin during a House Science Committee hearing, Tuesday, June 28, 2005, Rayburn House Office building, Washington. Photo Credit: (NASA/Bill Ingalls)

ASK Talks with Dr. Michael Hecht

NASA Technical Reports Server (NTRS)

Hecht, Michael

2003-01-01

Michael Hecht has been a member of NASA's Jet Propulsion Laboratory (JPL) staff since 1982. He is currently Project Manager and co-investigator for the Mars Environmental Compatibility Assessment (MECA)

Michael Thackeray on Lithium-air Batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thackeray, Michael

2009-01-01

Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

Michael Thackeray on Lithium-air Batteries

ScienceCinema

Thackeray, Michael

2018-02-06

Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

The Diary of Frances Jacobs: Astronomical Observations by a 19th-century Oregon Woman

NASA Astrophysics Data System (ADS)

McGown, R. D.

2002-12-01

This abstract summarizes my research, transcription and editing of Francis Jacob's 170-page handwritten astronomical diary. This diary is a unique example of a time in early Portland history, illustrating the mind of a young woman who was interested in science and astronomy. Reflected in her diary are the discoveries and mention of leading astronomers of the day like Emerson Bernard and Edward Pickering. Francis Jacobs lived in an era of the great refractors For example, ``The Leviathan," built by Lord Rosse in Ireland was completed in 1847. In this 72-inch telescope, stars of 18th magnitude could be seen. The first spiral nebulae to be revealed was M51 - known today as the Whirlpool Galaxy. The Earl was the first to suggest that these spirals could actually be rotating masses of stars. At the turn of the century, study of observational astronomy was rooted in naked eye observing, study of binary stars and nebula. This was a time when women were becoming interested in the sciences and had begun to play an important role in science and astronomy. It was an incredible inspiration for other women across the country to hear what was happening on the astronomical frontiers at Harvard. Some constellation asterisms used in Francis Jacob's diary were different than they are today. One asterism in particular, the Egyptian Cross, is relatively unknown now. The summer triangle and winter circle asterisms were used in her notes and obviously popular in her era, as today. Her written comments included some Messier catalogue numbers and in some case written on her sketches and diagrams nicknames, such as the 'Dumbbell' nebula. She also referred to M99 as `St. Katherine's Wheel', a nickname that is not in common use today.

Following Michael Faraday's Footprints

ERIC Educational Resources Information Center

Galeano, Javier

2011-01-01

Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

The Michael Reaction

NASA Astrophysics Data System (ADS)

Poon, Thomas; Mundy, Bradford P.; Shattuck, Thomas W.

2002-02-01

A brief account of the Michael reaction is provided, illustrating its versatility as a topic in undergraduate chemistry courses. Included is a short biography of the reaction's namesake, examples of its use in organic synthesis, and its unique role in the defense mechanism of the bacterium Micromonospora echinospora. A computational rationale for the selectivity of 1,4 versus 1,2 addition of nucleophiles to a,b-unsaturated carbonyls is discussed and links to animations suitable for an introductory organic chemistry course are provided.

Catalytic asymmetric Michael reactions promoted by a lithium-free lanthanum-BINOL complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sasai, Hiroaki; Arai, Takayoshi; Shibasaki, Masakatsu

1994-02-23

In this communication, we report about a new lithium-free BINOL-lanthanum complex, which is quite effective in catalytic asymmetric Michael reaction. We have succeeded in developing effective asymmetric base catalysts, in particular, asymmetric ester enolate catalysts for asymmetric Michael reactions. Two asymmetric lanthanum complexes are now available, namely, BINOL-lanthanum-lithium complex, which is quite effective in catalytic asymmetric nitrosaldol reactions, and a new lithium-free BINOL-lanthanum ester enolate complex, that is very effective in catalytic asymmetric Michael reactions. The two complexes complement each other in their ability to catalyze asymmetric nitroaldol and asymmetric Michael reactions. 14 refs., 1 fig., 2 tabs.

Michael Griffin House Science Committee Hearing

NASA Image and Video Library

2005-06-27

Members of the media photograph NASA Administrator Michael Griffin as he testifies at a hearing before the House Science Committee, Tuesday, June 28, 2005, Rayburn House Office building, Washington. Photo Credit: (NASA/Bill Ingalls)

Obituary: Michael James Ledlow, 1964-2004

NASA Astrophysics Data System (ADS)

Puxley, Philip John; Grashuis, Randon M.

2004-12-01

Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

NASA Catches Tropical Storm Leslie and Hurricane Michael in the Atlantic

NASA Image and Video Library

2017-12-08

This visible image of Tropical Storm Leslie and Hurricane Michael was taken by the MODIS instrument aboard both NASA's Aqua and Terra satellites on Sept. 9 at 12:50 p.m. EDT. Credit: NASA Goddard/MODIS Rapid Response Team -- Satellite images from two NASA satellites were combined to create a full picture of Tropical Storm Leslie and Hurricane Michael spinning in the Atlantic Ocean. Imagery from NASA's Aqua and Terra satellites showed Leslie now past Bermuda and Michael in the north central Atlantic, and Leslie is much larger than the smaller, more powerful Michael. Images of each storm were taken by the Moderate Resolution Imaging Spectroradiometer, or MODIS instrument that flies onboard both the Aqua and Terra satellites. Both satellites captured images of both storms on Sept. 7 and Sept. 10. The image from Sept. 7 showed a much more compact Michael with a visible eye. By Sept. 10, the eye was no longer visible in Michael and the storm appeared more elongated from south to north. To continue reading go to: 1.usa.gov/NkUPqn NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Interview with Michael Apple: The Biography of a Public Intellectual

ERIC Educational Resources Information Center

Peters, Michael A.

2015-01-01

Michael W. Apple is the John Bascom Professor of Curriculum and Instruction and Educational Policy Studies in the Departments of Curriculum and Instruction (CI) and Educational Policy Studies (EPS) at the University of Wisconsin-Madison School of Education where he has taught since 1970. Michael Apple is one of the foremost educational theorists…

Michael Griffin Oath Of Office

NASA Image and Video Library

2005-04-14

John H. Marburger, Science Adviser to the President and Director of the Office of Science and Technology Policy (OSTP), left, talks with NASA Administrator Michael Griffin, center, while his wife Rebecca and daughter Katie look on following his swearing-in, Thursday, April 14, 2005, in Washington. Photo Credit: (NASA/Renee Bouchard)

Michael Beitz: Objects of Communication

ERIC Educational Resources Information Center

Hoefferle, Mary

2014-01-01

For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

Michael Faraday, media man.

PubMed

Fara, Patricia

2006-03-01

Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles.

Synthesis of Triazole Derivatives of Levoglucosenone As Promising Anticancer Agents: Effective Exploration of the Chemical Space through retro-aza-Michael//aza-Michael Isomerizations.

PubMed

Tsai, Yi-Hsuan; Borini Etichetti, Carla M; Di Benedetto, Carolina; Girardini, Javier E; Martins, Felipe Terra; Spanevello, Rolando A; Suárez, Alejandra G; Sarotti, Ariel M

2018-04-06

The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents are described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by affording novel types of triazoles, difficult to obtain otherwise. Following this strategy, 2,4-disubstituted 1,2,3-triazoles could be efficiently obtained from the corresponding 1,4-disubstituted analogues.

Jane Jacobs and ‘The Need for Aged Buildings’: Neighbourhood Historical Development Pace and Community Social Relations

EPA Science Inventory

Jacobs argued that grand planning schemes intending to redevelop large swaths of a city according to a central theoretical framework fail because planners do not understand that healthy cities are organic, spontaneous, messy, complex systems that result from evolutionary proces...

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-12

Dr. Michael Griffin testifies, Tuesday, April 12, 2005, during his confirmation hearing before the U.S. Senate Commerce Committee at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-11

Dr. Michael Griffin testifies, Tuesday, April 12, 2005, during his confirmation hearing before the U.S. Senate Commerce Committee at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

Michael Akam and the rise of evolutionary developmental biology

PubMed Central

Stern, David L.; Dawes-Hoang, Rachel E.

2010-01-01

Michael Akam has been awarded the 2007 Kowalevsky medal for his many research accomplishments in the area of evolutionary developmental biology. We highlight three tributaries of Michael’s contribution to evolutionary developmental biology. First, he has made major contributions to our understanding of development of the fruit fly, Drosophila melanogaster. Second, he has maintained a consistent focus on several key problems in evolutionary developmental biology, including the evolving role of Hox genes in arthropods and, more recently, the evolution of segmentation mechanisms. Third, Michael has written a series of influential reviews that have integrated progress in developmental biology into an evolutionary perspective. Michael has also made a large impact on the field through his effective mentorship style, his selfless promotion of younger colleagues, and his leadership of the University Museum of Zoology at Cambridge and the European community of evolutionary developmental biologists. PMID:20209429

The Birth and Development of Sociometry: The Work and Legacy of Jacob Moreno (1889-1974)

ERIC Educational Resources Information Center

Marineau, Rene F.

2007-01-01

This article profiles Jacob Levy Moreno, the founder of this journal. He was born in 1889 in Romania, but moved to Vienna with his parents when he was four years of age. By all accounts, Moreno as a child was brilliant, spontaneous, creative and, presaging his later successes, was fascinated by relationships, first with his brothers and sisters,…

Michael Griffin Oath Of Office

NASA Image and Video Library

2005-04-14

NASA Administrator Michael Griffin, left, is administered the oath of office by John H. Marburger, right, Science Adviser to the President and Office of Science and Technology Policy Director, during a private ceremony at the Old Executive Office Building, Thursday, April 14, 2005, in Washington, while his wife Rebecca and daughter Katie look on. Photo Credit: (NASA/Renee Bouchard)

Markets, Marx, Modernity and Mathematics Education: A Response to Michael Apple.

ERIC Educational Resources Information Center

Gates, Peter

This paper is a response to Michael Apple's paper, "What Postmodernists Forget: Cultural Capital and Official Knowledge." The paper advocates Michael's identification of the current dangers and processes of the growth of new right ideologies in the development of subjectivity, society, and education. The differences in success in the education…

Michael Griffin Meets with Elon Musk

NASA Image and Video Library

2005-04-19

NASA Administrator Michael Griffin, left, meets with CEO of SpaceX Elon Musk, right, Wednesday, April 20, 2005 at NASA Headquarters in Washington. Looking on in the background are Larry Williams, NASA astronaut Marsha Ivins and NASA manager Christopher Shank. Photo Credit: (NASA/Renee Bouchard)

Michael Sadler and the German Connection.

ERIC Educational Resources Information Center

Higginson, J. H.

1990-01-01

Chronicles works of Michael Sadler who compared British and German educational systems, emphasizing Germany's contributions in technical education. Presents Sadler's 1912 recommendations--eight lessons premised upon powerful centralized government's ability to implement policy. Reflects on how World War I and Nazism influenced Sadler's thought and…

Michael Polanyi: Science as Personal Knowledge and Social Practice.

PubMed

Nye, Mary Jo

2017-03-20

Tacit knowing: 2016 marked the 125th anniversary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his death. This essay discusses his philosophy of science-in particular, his most significant work in this area, Personal Knowledge-from the perspective of his personal biography, as well as its lasting influence on the social sciences. In the photograph: Michael Polanyi at the Fritz Haber Institute in 1968. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Asymmetric Michael Addition Mediated by Chiral Ionic Liquids.

PubMed

Suzuki, Yumiko

2018-06-01

Chiral ionic liquids with a focus on their applications in asymmetric Michael additions and related reactions were reviewed. The examples were classified on the basis of the mode of asymmetric induction (e.g., external induction/non-covalent interaction or internal induction/covalent bond formation), the roles in reactions (as a solvent or catalyst), and their structural features (e.g., imidazolium-based chiral cations, other chiral oniums; proline derivatives). Most of the reactions with high chiral induction are Michael addition of ketones or aldehydes to chalcones or nitrostyrenes where proline-derived chiral ionic liquids catalyze the reaction through enamine/ iminium formation. Many reports demonstrate the recyclability of ionic liquid-tagged pyrrolidines.

Informing Physics: Jacob Bekenstein and the Informational Turn in Theoretical Physics

NASA Astrophysics Data System (ADS)

Belfer, Israel

2014-03-01

In his PhD dissertation in the early 1970s, the Mexican-Israeli theoretical physicist Jacob Bekenstein developed the thermodynamics of black holes using a generalized version of the second law of thermodynamics. This work made it possible for physicists to describe and analyze black holes using information-theoretical concepts. It also helped to transform information theory into a fundamental and foundational concept in theoretical physics. The story of Bekenstein's work—which was initially opposed by many scientists, including Stephen Hawking—highlights the transformation within physics towards an information-oriented scientific mode of theorizing. This "informational turn" amounted to a mild-mannered revolution within physics, revolutionary without being rebellious.

Michael Fisher at King's College London

NASA Astrophysics Data System (ADS)

Domb, Cyril

1991-09-01

Michael Fisher spent the first 16 years of his academic life in the Physics Department of King's College, London, starting as an undergraduate and ending as a full professor. A survey is undertaken of his activities and achievements during the various periods of this phase of his career.

Michael Fisher at King's College London

NASA Astrophysics Data System (ADS)

Domb, Cyril

Michael Fisher spent the first 16 years of his academic life in the Physics Department of King's College, London, starting as an undergraduate and ending as a full professor. A survey is undertaken of his activities and achievements during the various periods of this phase of his career.

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-12

Dr. Michael Griffin, right, talks with his wife Rebecca Griffin prior to testifying at his confirmation hearing before the U.S. Senate Commerce Committee, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

75 FR 22436 - Michael Williams-Control Exemption-St. Maries River Railroad, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35365] Michael Williams-Control Exemption-St. Maries River Railroad, Inc. Michael Williams (applicant),\\1\\ a noncarrier, has filed a verified notice of exemption to acquire control of St. Maries River Railroad, Inc. (STMA), a Class...

Meet EPA Scientist Michael Nye, Ph.D.

EPA Pesticide Factsheets

Michael Nye, Ph.D., is a social scientist who studies natural risk, socio-demographic change and sustainable behavior. Prior to joining EPA, he worked for the UK Environment Agency in flood risk management and emergency preparedness

Comments on Michael (1993): Establishing Operations

ERIC Educational Resources Information Center

Moore, J.

2013-01-01

The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but…

Studying Teachers and Schools: Michael Pressley's Legacy and Directions for Future Research

ERIC Educational Resources Information Center

Mohan, Lindsey; Lundeberg, Mary A.; Reffitt, Kelly

2008-01-01

Much of Michael Pressley's work during the past decade focused on the nature of highly effective, engaging literacy instruction. Michael Pressley believed that studying effective teachers and schools had the potential to influence more engaging and effective teaching, especially in underresourced schools. First, we describe the grounded…

Asymmetric Michael Addition Mediated by Chiral Ionic Liquids

PubMed Central

Suzuki, Yumiko

2018-01-01

Chiral ionic liquids with a focus on their applications in asymmetric Michael additions and related reactions were reviewed. The examples were classified on the basis of the mode of asymmetric induction (e.g., external induction/non-covalent interaction or internal induction/covalent bond formation), the roles in reactions (as a solvent or catalyst), and their structural features (e.g., imidazolium-based chiral cations, other chiral oniums; proline derivatives). Most of the reactions with high chiral induction are Michael addition of ketones or aldehydes to chalcones or nitrostyrenes where proline-derived chiral ionic liquids catalyze the reaction through enamine/ iminium formation. Many reports demonstrate the recyclability of ionic liquid-tagged pyrrolidines. PMID:29861702

Integrating International Students into Tertiary Education Using Intercultural Peer-to-Peer Training at Jacobs University Bremen, Germany

ERIC Educational Resources Information Center

Binder, Nadine; Schreier, Margrit; Kühnen, Ulrich; Kedzior, Karina Karolina

2013-01-01

Increasing internationalization of higher education raises the question of how well institutions prepare their students to integrate into and benefit from cultural diversity on any university campus. The aim of this study was to assess an intercultural peer-to-peer training at Jacobs University Bremen, Germany, that aims to facilitate the…

Common Aero Vehicle Autonomous Reentry Trajectory Optimization Satisfying Waypoint and No-Fly Zone Constraints

DTIC Science & Technology

2007-09-01

Control Conference and Exhibit. 5-8 August 2002. AIAA-2002-4457. 25. ElGindy, Hossam and Lachlan Wetherall. “A Simple Voronoi Diagram Algorithm for a...Jacobs, Thomas H., Elan T. Smith , and Michael W. Garrambone. “Space Ac- cess Vehicles Mission and Operations Simulation (SAVMOS) For Simulating

Directions in Rehabilitation Counseling, 2001.

ERIC Educational Resources Information Center

Flach, Frederic, Ed.

2001-01-01

This volume of 12 lessons provides expert information on a variety of medical and psychological issues in rehabilitative counseling. The lessons, which may be applied toward continuing education credits, are: (1) "Integration of Psychiatric Treatment and Rehabilitation" (Jeanne Steiner, Larry Davidson, Michael A. Hoge, and Selby Jacobs);…

Michael Slote and "Sentimentalist Moral Education"

ERIC Educational Resources Information Center

Wren, Thomas

2010-01-01

Although I think most of what Michael Slote asserts in his article "Sentimentalist moral education" is correct, I worry about three important ideas that are conspicuous by their absence. The first is the possibility that human emotions and feelings are inherently cognitive, which is never considered in his psychological account of empathy. The…

77 FR 61596 - Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-10

...] Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing Take notice that on September 28, 2012, Michael I. Wheatley and Drummond E. Garrison submitted for filing, an application for authority to hold... the ``eFiling'' link at http://www.ferc.gov . Persons unable to file electronically should submit an...

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-12

U.S. Senator Daniel K. Inouye, D-Hawaii, left, speaks as U.S. Senator Ted Stevens, R-Alaska, looks on during the confirmation hearing for Dr. Michael Griffin, in front of the U.S. Senate Commerce Committee, Tuesday, April 12, 2005, in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-12

U.S. Senator Barbara Mikulski, D-Md., testifies before the U.S. Senate Commerce Committee during the confirmation hearing of Dr. Michael Griffin, rear center, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. Griffin currently heads the space department at Johns Hopkins University's Applied Physics Laboratory. If confirmed by the full U.S. Senate, Dr. Griffin would be NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-11

U.S. Senator Barbara Mikulski, D-Md., testifies before the U.S. Senate Commerce Committee during the confirmation hearing of Dr. Michael Griffin, rear center, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. Griffin currently heads the space department at Johns Hopkins University's Applied Physics Laboratory. If confirmed by the full U.S. Senate, Dr. Griffin would be NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-12

U.S. Senator Barbara Mikulski, D-Md., left, talks with Michael Griffin as Senator Kay Bailey Hutchison, R-Tx., and Griffin's wife Rebecca look on prior to his testimony, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

Michael Griffin Senate Confirmation Hearing

NASA Image and Video Library

2005-04-12

U.S. Senator Barbara Mikulski, D-Md., testifies before the U.S. Senate Commerce Committee during the confirmation hearing of Dr. Michael Griffin, right background, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. Griffin currently heads the space department at Johns Hopkins University's Applied Physics Laboratory. If confirmed by the full U.S. Senate, Dr. Griffin would be NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

A Bibliographic Tribute to Jack Michael

ERIC Educational Resources Information Center

Esch, Barbara E.; Esch, John W.

2016-01-01

"In the late 1950's, Jack Michael, a bright but irritating young psychology instructor, moved from the Universities of Kansas to Houston to Arizona State. Along the way he befriended two nontraditional students, protected them through their Ph.D. programs, and turned them loose on the world: Teodoro Ayllon…and Montrose Wolf…" (Risley,…

Meet EPA Ecologist Michael Murrell, Ph.D.

EPA Pesticide Factsheets

Michael Murrel, Ph.D., is a EPA research ecologist working on the Gulf of Mexico Hypoxia Project, helping develop models of the northern Gulf to quantify the links between freshwater flowing into the Gulf from the land, nutrients, and hypoxia—“dead zones”

76 FR 55904 - Michael J. Donahue; Notice of Termination of Exemption By Implied Surrender and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 6649-008] Michael J.... Date Initiated: September 1, 2011. d. Exemptee: Michael J. Donahue. e. Name and Location of Project.... Initiated Pursuant to: 18 CFR 4.106. g. Exemptee Contact Information: Mr. Michael J. Donahue, Route 3, Box...

76 FR 58264 - Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 6649-008] Michael J.... Date Initiated: September 13, 2011. d. Exemptee: Michael J. Donahue. e. Name and Location of Project.... Initiated Pursuant to: 18 CFR 4.106. g. Exemptee Contact Information: Mr. Michael J. Donahue, Route 3, Box...

75 FR 62635 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-12

... Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request... determine patients' satisfaction with services provided by or through the Michael E. DeBakey Home Care...: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number...

77 FR 69550 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-19

... (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request AGENCY... information needed to determine patients' satisfaction with services provided by or through the Michael E...: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number...

A Phenomenological Examination of Virtual Game Developers' Experiences Using Jacob's Ladder Pre-Production Design Tactic

ERIC Educational Resources Information Center

Brown-Turner, Jasmine

2017-01-01

Edutainment refers to curriculum and instruction designed with a clear educational purpose, including multi-faceted virtual learning game design. Tools such as the Jacob's Ladder pre-production design tactic have been developed to ensure that voices of both engineers and educators are heard. However, it is unclear how development team members…

Surface Modified Particles By Multi-Step Michael-Type Addition And Process For The Preparation Thereof

DOEpatents

Cook, Ronald Lee; Elliott, Brian John; Luebben, Silvia DeVito; Myers, Andrew William; Smith, Bryan Matthew

2005-05-03

A new class of surface modified particles and a multi-step Michael-type addition surface modification process for the preparation of the same is provided. The multi-step Michael-type addition surface modification process involves two or more reactions to compatibilize particles with various host systems and/or to provide the particles with particular chemical reactivities. The initial step comprises the attachment of a small organic compound to the surface of the inorganic particle. The subsequent steps attach additional compounds to the previously attached organic compounds through reactive organic linking groups. Specifically, these reactive groups are activated carbon—carbon pi bonds and carbon and non-carbon nucleophiles that react via Michael or Michael-type additions.

Michael Griffin Discusses Exploration Architecture Study

NASA Image and Video Library

2005-09-18

NASA Administrator Michael Griffin discusses the results of the agency's exploration architecture study on Monday, Sept. 19, 2005, at NASA Headquarters in Washington. The study made specific design recommendations for a vehicle to carry crews into space, a family of launch vehicles to take missions to the moon and beyond, and a "lunar mission architecture" for landing on the moon. Photo Credit: (NASA/Bill Ingalls)

Solving the Housing Equation: Michael P. Johnson

ERIC Educational Resources Information Center

Roach, Ronald

2005-01-01

Dr. Michael P. Johnson, an associate professor of management science and urban affairs at the H. John Heinz III School of Public Policy and Management at Carnegie Mellon University in Pittsburgh, is taking management science tools and innovative information technology applications to the housing field. Concerned that organizations that develop and…

"Anti-Michael addition" of Grignard reagents to sulfonylacetylenes: synthesis of alkynes.

PubMed

Esteban, Francisco; Boughani, Lazhar; García Ruano, José L; Fraile, Alberto; Alemán, José

2017-05-10

In this work, the addition of Grignard reagents to arylsulfonylacetylenes, which undergoes an "anti-Michael addition", resulting in their alkynylation under very mild conditions is described. The simplicity of the experimental procedure and the functional group tolerance are the main features of this methodology. This is an important advantage over the use of organolithium at -78 °C that we previously reported. Moreover, the synthesis of diynes and other examples showing functional group tolerance in this anti-Michael reaction is also presented.

Reframing Michael Scott: Exploring Inappropriate Workplace Communication

ERIC Educational Resources Information Center

Schaefer, Zachary A.

2010-01-01

Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

Against Dogma: A Reply to Michael Swan.

ERIC Educational Resources Information Center

Widdowson, H. G.

1985-01-01

Replies to two articles by Michael Swan entitled "A Critical Look at the Communicative Approach." Argues that Swan presents a distorted version of the communicative approach so as to present his own ideas more effectively and that he fails to offer evidence for his position on the practice of English language teaching. (SED)

The legacy of Michael Balint.

PubMed

Johnson, Alan H; Brock, Clive D; Zacarias, Ashleigh

2014-01-01

Michael Balint's lead article, "Repeat Prescription Patients: Are They An Identifiable Group?" inaugurated the first issue of Psychiatry in Medicine, Vol. 1, No. 1, 1970. A few years later, this Journal would be renamed International Journal of Psychiatry in Medicine (IJPM). Who is this author of over 165 papers, 10 books, practicing psychoanalyst from 1926 to 1970, director of the Budapest Psychoanalytic Institute from 1935 to 1939, consultant at the Tavistock Clinic from 1948 to 1961, President of the British Psycho-Analytical Society from 1968 to 1970, literary executor of Sandor Ferenczi, a foremost theorist of object relations, and international educator and statesman for general practitioners? We would like to review for you some of the formative experiences in Michael's life that wedded psychoanalysis and general practice, and how they contributed to his major educational commitment over 40 years to furthering the understanding and integration of psychosocial factors in the practice of primary healthcare as experienced by doctors all over the world. We would also like to highlight some of his major insights and see to what extent they are incorporated in contemporary medical education and practice. We believe that some of his major insights have been neglected and others have been further amplified and extended. Our intention is to speak not only to medical students who desire to pursue medicine related directly to patient care but as well to seasoned practitioners who continue on a daily basis to care for individual patients and their families.

MICHAEL "RUDI" RUDOLPHI SPEAKING AT MISSION SUCCESS FORUM

NASA Image and Video Library

2016-06-16

MICHAEL "RUDI" RUDOLPHI GESTURES DURING A "MISSION SUCCESS IS IN OUR HANDS" SHARED EXPERIENCES FORUM JUNE 16, WHERE HE SPOKE ABOUT HIS "UNFORGETTABLE" EXPERIENCES AS A SENIOR NASA REPRESENTATIVE OVERSEEING DEBRIS RECOVERY EFFORTS FOLLOWING THE LOSS OF SPACE SHUTTLE COLUMBIA AND ITS CREW.

Zebrafish Model of NF1 for Structure-Function Analysis, Mechanisms of Glial Tumorigenesis, and Chemical Biology

DTIC Science & Technology

2013-05-01

Feng Guo1, Shuning He1, Marc A. Wolman2, Michael Granato2, Nathan D. Lawson4, Scot A. Wolfe4, Seok-Hyung Kim5, Lilianna Solnica-Krezel6, John P...gliomas. J. Neuropathol. Exp. Neurol. 63, 499- 509. Lyons, D. A., Pogoda, H. M., Voas, M. G., Woods , I. G., Diamond, B., Nix, R., Arana, N., Jacobs

Proceedings of the Annual Meeting of the Council of Graduate Schools in the United States.

ERIC Educational Resources Information Center

Ryan, John W., Ed.

The 1973 meeting of the Council of Grauate Schools is reported including a panel on "Scholarship for Society" by Michael J. Pelczar, Jr., Ralph E. Morrow, Joe N. Gerber, and Jacob E. Cobb. Other discussion groups include evaluation of graduate programs by Arthur C. Gentile, Frank E. Horton, and John T. Kirby; governance and organization by John K.…

Michael Driver: A Career Life to Remember

ERIC Educational Resources Information Center

Sundby, Dianne; Derr, C. Brooklyn

2007-01-01

Purpose: The purpose of this paper is to present a retrospective of the career life of Michael Driver, from the time of his Princeton graduate studies and early faculty years at Purdue University through the over three decades he spent at USC. Design/methodology/approach: The history and development of his theoretical and research interests are…

Michael Walzer's Politics, in Theory and Practice

ERIC Educational Resources Information Center

Williams, Jeffrey J.

2012-01-01

Before all the talk about "public intellectuals," Michael Walzer was one. For 50 years, he has gone back and forth between positions at Princeton and Harvard Universities and then at the Institute for Advanced Study, in Princeton, New Jersey, where he is now emeritus. His writings appear regularly in "Dissent" magazine, which he has co-edited for…

Psychological vulnerability and problem gambling: an application of Durand Jacobs' general theory of addictions to electronic gaming machine playing in Australia.

PubMed

McCormick, Jessica; Delfabbro, Paul; Denson, Linley A

2012-12-01

The aim of this study was to conduct an empirical investigation of the validity of Jacobs' (in J Gambl Behav 2:15-31, 1986) general theory of addictions in relation to gambling problems associated with electronic gaming machines (EGM). Regular EGM gamblers (n = 190) completed a series of standardised measures relating to psychological and physiological vulnerability, substance use, dissociative experiences, early childhood trauma and abuse and problem gambling (the Problem Gambling Severity Index). Statistical analysis using structural equation modelling revealed clear relationships between childhood trauma and life stressors and psychological vulnerability, dissociative-like experiences and problem gambling. These findings confirm and extend a previous model validated by Gupta and Derevensky (in J Gambl Stud 14: 17-49, 1998) using an adolescent population. The significance of these findings are discussed for existing pathway models of problem gambling, for Jacobs' theory, and for clinicians engaged in assessment and intervention.

Reading Michael Apple--The Sociological Imagination at Work

ERIC Educational Resources Information Center

Ball, Stephen J.

2007-01-01

This article discusses Michael Apple's contribution to the sociology of education and education policy analysis and the politics of education. It focuses on ways of "reading" Apple as an intellectual and an activist and looks at the trajectory of his work over a long and illustrious career.

Production of Low-Freezing-Point Highly Branched Alkanes through Michael Addition.

PubMed

Jing, Yaxuan; Xia, Qineng; Liu, Xiaohui; Wang, Yanqin

2017-12-22

A new approach for the production of low-freezing-point, high-quality fuels from lignocellulose-derived molecules was developed with Michael addition as the key step. Among the investigated catalysts, CoCl 2 ⋅6 H 2 O was found most active for the Michael addition of 2,4-pentanedione with FA (single aldol adduct of furfural and acetone, 4-(2-furanyl)-3-butene-2-one). Over CoCl 2 ⋅6 H 2 O, a high carbon yield of C 13 oxygenates (about 75 %) can be achieved under mild conditions (353 K, 20 h). After hydrodeoxygenation, low-freezing-point (<223 K) branched alkanes with 13 carbons within jet fuel ranges were obtained over a Pd/NbOPO 4 catalyst. Furthermore, C 18,23 fuel precursors could be easily synthesized through Michael addition of 2,4-pentanedione with DFA (double-condensation product of furfural and acetone) under mild conditions and the molar ratio of C 18 /C 23 is dependent on the reaction conditions of Michael addition. After hydrodeoxygenation, high density (0.8415 g mL -1 ) and low-freezing-point (<223 K) branched alkanes with 18, 23 carbons within lubricant range were also obtained over a Pd/NbOPO 4 catalyst. These highly branched alkanes can be directly used as transportation fuels or additives. This work opens a new strategy for the synthesis of highly branched alkanes with low freezing point from renewable biomass. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Unseen Déjà-Vu: From Erkki Huhtamo's Topoi to Ken Jacobs' Remakes: Commentary to Edwin Carels "Revisiting Tom Tom: Performative anamnesis and autonomous vision in Ken Jacobs' appropriations of Tom Tom the Piper's Son".

PubMed

Strauven, Wanda

2018-01-01

This commentary on Edwin Carels' essay "Revisiting Tom Tom : Performative anamnesis and autonomous vision in Ken Jacobs' appropriations of Tom Tom the Piper's Son " broadens up the media-archaeological framework in which Carels places his text. Notions such as Huhtamo's topos and Zielinski's "deep time" are brought into the discussion in order to point out the difficulty to see what there is to see and to question the position of the viewer in front of experimental films like Tom Tom the Piper's Son and its remakes.

The Scriptural Cantatas "Esther" and "Jacob, et Rachel" of Elisabeth-Claude Jacquet de La Guerre: Historical Context and Performance Practice

ERIC Educational Resources Information Center

Buckley, Elizabeth M.

2009-01-01

This project explores two sacred cantatas of Elisabeth-Claude Jacquet de La Guerre, "Esther" and "Jacob, et Rachel". The cultural milieu in which the sacred cantatas of Jacquet de La Guerre were written and performed will be discussed, as well as possible venues for their original performances, including the Parisian salon, and…

A multi-armed bandit approach to superquantile selection

DTIC Science & Technology

2017-06-01

decision learning, machine learning, intelligence processing, intelligence cycle, quantitative finance. 15. NUMBER OF PAGES 73 16. PRICE CODE 17...fulfillment of the requirements for the degree of MASTER OF SCIENCE IN OPERATIONS RESEARCH from the NAVAL POSTGRADUATE SCHOOL June 2017 Approved by...Roberto S. Szechtman Thesis Advisor Michael P. Atkinson Second Reader Patricia A. Jacobs Chair, Operations Research Department iii THIS PAGE

Astronaut Michael Clifford takes a break during bailout training

NASA Technical Reports Server (NTRS)

1993-01-01

Astronaut Michael R.U. (Rich) Clifford takes a break while video taping crew mates in training in the JSC Weightless Environment Training Facility (WETF). He is pictured with Trent G. Keeple, a member of the training staff assigned to STS-59.

Michael Hand, Indoctrination and the Inculcation of Belief

ERIC Educational Resources Information Center

Tan, Charlene

2004-01-01

In 'Religious Upbringing Reconsidered,' Michael Hand revisits the debate on the right of parents to give their children a religious upbringing in a liberal context. According to him, the logical difficulty lies in the fact that parents cannot both impart religious beliefs and avoid indoctrination. While Peter Gardner and Jim Mackenzie have…

The Critical Pedagogical Potential of Using Jacob A. Riis' Works about the Immigrant Poor in "Gilded Age" New York

ERIC Educational Resources Information Center

Templer, Bill

2017-01-01

The article seeks to contribute to working-class and social justice pedagogy by developing concrete angles on teaching/exploring some of the (a) short fiction, (b) journalistic-photographic work and (c) sociography of poverty by the Danish-born US immigrant, muckraker (http://goo.gl/6WeGtM) and social reformer Jacob A. Riis (1849-1914,…

76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request... Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home... satisfaction with the quality of services/care provided by home care program staff. An agency may not conduct...

The Holocaust and Education: An Interview with Michael Berenbaum.

ERIC Educational Resources Information Center

Goldberg, Mark

1997-01-01

In January 1997, Michael Berenbaum became president and chief executive officer of Survivors of the Shoah Visual History Foundation, the organization established by filmmaker Steven Spielberg after completing "Schindler's List." Since 1994, the foundation has been recording eyewitness testimony on the Holocaust. Berenbaum's mandate is to…

Dr. Michael DeBakey "is a magician of the heart…"

MedlinePlus

... Dr. DeBakey with NLM's David Nash and admiring students from the Michael E. DeBakey High School for ... medical research as the means of discovering improved methods of diagnosis, treatment, prevention, and cure. As far ...

78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-31

... (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request AGENCY... Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number: 2900-0775. Type... gather feedback from patients regarding their satisfaction with the quality of services/care provided by...

Michael Polanyi on the Education and Knowledge of Scientists.

ERIC Educational Resources Information Center

Jacobs, Struan

2000-01-01

Explains why teachers addressing the nature of science should know the work of Michael Polanyi. Outlines Polanyi's intellectual career and examines his ideas on the education of scientists, research, and knowledge. Polanyi presaged Kuhn, Feyerabend, and the constructivists, yet insisted that science produces true knowledge about reality. (Contains…

Meeting Report: 1st International Functional Metagenomics Workshop May 7–8, 2012, St. Jacobs, Ontario, Canada.

PubMed Central

Engel, Katja; Ashby, Deborah; Brady, Sean F.; Cowan, Don A.; Doemer, John; Edwards, Elizabeth A.; Fiebig, Klaus; Martens, Eric C.; McCormac, Dennis; Mead, David A.; Miyazaki, Kentaro; Moreno-Hagelsieb, Gabriel; O’Gara, Fergal; Reid, Alexandra; Rose, David R.; Simonet, Pascal; Sjöling, Sara; Smalla, Kornelia; Streit, Wolfgang R.; Tedman-Jones, Jennifer; Valla, Svein; Wellington, Elizabeth M. H.; Wu, Cheng-Cang; Liles, Mark R.; Neufeld, Josh D.; Sessitsch, Angela

2013-01-01

This report summarizes the events of the 1st International Functional Metagenomics Workshop. The workshop was held on May 7 and 8, 2012, in St. Jacobs, Ontario, Canada and was focused on building an international functional metagenomics community, exploring strategic research areas, and identifying opportunities for future collaboration and funding. The workshop was initiated by researchers at the University of Waterloo with support from the Ontario Genomics Institute (OGI), Natural Sciences and Engineering Research Council of Canada (NSERC) and the University of Waterloo. PMID:23961315

Tweeting Prayers and Communicating Grief over Michael Jackson Online

ERIC Educational Resources Information Center

Sanderson, Jimmy; Cheong, Pauline Hope

2010-01-01

Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

A Good Time: A Conversation with C. Michael Nelson

ERIC Educational Resources Information Center

Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

2015-01-01

C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

ERIC Educational Resources Information Center

Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

2016-01-01

A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

What Works, Works Everywhere: Q&A with Michael Barber

ERIC Educational Resources Information Center

Crow, Tracy

2009-01-01

This article presents an interview with Michael Barber, a partner at McKinsey & Company, leading its global education practice. He has been working on major challenges of performance, organization, and reform in government and the public services, especially education, in the U.S., U.K., and other countries. Barber was instrumental in preparing…

Michael J. Fox and his Parkinson's disease.

PubMed

Kempster, Peter A

2004-01-01

Michael J. Fox was a popular and successful film and television comic actor who developed Parkinson's disease at the age of 29 years. His recently published book, Lucky Man, structured around the story of his Parkinson's disease, is an amusing, briskly paced yet introspective memoir that covers the first 40 years of his life. Although quite anecdotal, it contains interesting observations on the preclinical phase of the disorder, evolution of motor fluctuations, and tactics for pharmacological treatment. Copyright 2003 Movement Disorder Society

[An exceptional human relationship (Michael P. Kierkegaard, Søren Kierkegaard)].

PubMed

Jacobs, R

1978-01-01

There were a father and a son, Michael and Sören Kierkegaard, both highly talented, imaginitive, witty, humorous, especially interested in shrewd dialectrical dialogues respectively debates, both profound melancholy ponderers. But according to very own individuality their congeniality wasn't absolute. The father, being under a questionable rigorous opinion of sin, suffered from undeserved divine grace since early childhood. And Michael Kierkegaard made Sören anxious with the religious experience of original sin. This anxiety moved (touched or affected) the sensitive son mighty. Nevertheless he should not despair hopelessly like his unlucky father. On the contrary: Sørens incomparable melancholy, mental agony and anxiety (fear or anguish) forced the faith, existing independently of them, in a radical refining. That is why Sören Kierkegaard succeeded in sublimation of all psychological and philosophic (al) attitudes (or opinions) in the sphere of religiousness. And the result? A novel philosophy of life: Christian existentialism.

HEADSTONES OF BERNARD AND MICHAEL JODD, FATHERANDSON CIVILIANS RESPONSIBLE FOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HEADSTONES OF BERNARD AND MICHAEL JODD, FATHER-AND-SON CIVILIANS RESPONSIBLE FOR CONSTRUCTION OF BRICK PERIMETER WALL WHO DIED OF YELLOW FEVER DURING WALL CONSTRUCTION. VIEW TO WEST. - Baton Rouge National Cemetery, 220 North 19th Street, Baton Rouge, East Baton Rouge Parish, LA

Operational art in the Defense: The German Abwehrschlachten in 1918

DTIC Science & Technology

2012-05-17

2 Carl von Clausewitz, On War, Michael Howard und Peter Paret ed. and trans. (New Jersey: Princeton University Press, 1989...Siegismund, 1937), 74. 21 Jacob Jung , Max von Gallwitz (1852-1937) (Osnabrück: Biblio-Verlag, 1995), 93 & 97. 22 Erich Ludendorff, Meine...23 Jung , Max von Gallwitz (1852-1937), 5-7. 24 Ibid., 8-16. 25 Ibid.,17-23. 13 At the outbreak of the war, Gallwitz received command

New Models at Lasell: Q&A with President Michael Alexander

ERIC Educational Resources Information Center

Harney, John O.

2018-01-01

The "New England Journal of Higher Education" ("NEJHE") Executive Editor John O. Harney had the chance to catch up with Lasell College President Michael Alexander about the small Newton, Massachusetts, college's plans to challenge the higher education business model. The interview is presented in this article.

Monitoring Soil Erosion on a Burned Site in the Mojave-Great Basin Transition Zone: Final Report for the Jacob Fire Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, Julianne; Etyemezian, Vic; Cablk, Mary E.

A historic return interval of 100 years for large fires in the U.S. southwestern deserts is being replaced by one where fires may reoccur as frequently as every 20 to 30 years. The shortened return interval, which translates to an increase in fires, has implications for management of Soil Corrective Action Units (CAUs) and Corrective Action Sites (CASs) for which the Department of Energy, National Nuclear Security Administration Nevada Field Office has responsibility. A series of studies was initiated at uncontaminated analog sites to better understand the possible impacts of erosion and transport by wind and water should contaminated soilmore » sites burn. The first of these studies was undertaken at the Jacob Fire site approximately 12 kilometers (7.5 miles) north of Hiko, Nevada. A lightning-caused fire burned approximately 200 hectares during August 6-8, 2008. The site is representative of a transition between Mojave and Great Basin desert ecoregions on the Nevada National Security Site (NNSS), where the largest number of Soil CAUs/CASs are located. The area that burned at the Jacob Fire site was primarily a Coleogyne ramosissima (blackbrush) and Ephedra nevadensis (Mormon tea) community, also an abundant shrub assemblage in the similar transition zone on the NNSS. This report summarizes three years of measurements after the fire. Seven measurement campaigns at the Jacob Fire site were completed. Measurements were made on burned ridge (upland) and drainage sites, and on burned and unburned sites beneath and between vegetation. A Portable In-Situ Wind Erosion Lab (PI-SWERL) was used to estimate emissions of suspended particles at different wind speeds. Context for these measurements was provided through a meteorological tower that was installed at the Jacob Fire site to obtain local, relevant environmental parameters. Filter samples, collected from the exhaust of the PI-SWERL during measurements, were analyzed for chemical composition. Runoff and water erosion

Michael M. May: Working toward solutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

May, M.M.

1993-07-01

As part of LLNL's 40th anniversary celebration held during 1992, the six former Directors were asked to participate in a lecture series. Each of these men contributed in important ways toward making the Lawrence Livermore National Laboratory (LLNL) what it has become today. Each was asked to comment on some of the Laboratory's accomplishments, his career here, his view of the changing world, and where he sees the Laboratory going in the future. Michael M. May, LLNL's fifth Director and now a Director Emeritus, comments on a broad range of issues including arms control, nonproliferation, cooperative security, and the futuremore » role of the Laboratory.« less

2016 Summer Series - Michael Flynn - Synthetic Biological Membrane

NASA Image and Video Library

2016-08-02

Full understanding leads to creation capability, which results in customization capacity. Synthetic biology uses our knowledge of biology to engineer novel biological devices or organisms that can perform tasks not found in nature. For Human space exploration, synthetic biology approaches will reduce risk, mass carried and increase Human reach. Michael Flynn will discuss the International Space Station (ISS) water recycling and his current work on developing a water filtration system capable of self-repair.

78 FR 2391 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RP13-436-000] CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and Electric Company... Energy Regulatory Commission (FERC); CAlifornians for Renewable Energy, Inc., Michael E. Boyd, and Robert...

STS-34 Pilot Michael J. McCulley uses ARRIFLEX camera equipment

NASA Image and Video Library

1989-04-13

STS-34 Atlantis, Orbiter Vehicle (OV) 104, Pilot Michael J. McCulley squints while looking through ARRIFLEX camera eye piece during camera briefing at JSC. McCulley rests part of the camera on his shoulder as he operates it.

Educational Implications of Michael Fishbane's "Sacred Attunement: A Jewish Theology"

ERIC Educational Resources Information Center

Marom, Daniel

2008-01-01

This article posits Michael Fishbane's Judaic scholarship as a prime resource for Jewish education. The link between the two fields can be made through a translation of the theological underpinnings of Fishbane's insights into Judaism to educational purposes and practices. Initial work with Jewish educators on establishing this link encouraged…

Apollo 12 Mission image - High oblique view of crater Copernicus and Carpathian Mt. range

NASA Image and Video Library

1969-11-19

AS12-47-6876 (November 1969) --- An Apollo 12 high-oblique view of the lunar nearside looking northeast toward the crater Copernicus (in center near horizon), as photographed from lunar orbit. The shaded crater in the foreground is Reinhold. Reinhold B is the crater next to Reinhold which as the small crater in the center of it. Also, visible is the keyhole-shaped crater Fauth near the crater Copernicus.

Rethinking Drug Treatment Approaches in ALS by Targeting ABC Efflux Transporters

DTIC Science & Technology

2014-12-01

for ALS patients. One of the problems in finding highly efficacious treatments in ALS may derive from the so far underestimated issue of disease... efficacy the SOD1-G93A ALS mice. 15. SUBJECT TERMS Drug resistance, ALS, Therapy, Riluzole, Drug Efflux Transporters 16. SECURITY CLASSIFICATION OF...improves efficacy of ALS therapeutics Michael R. Jablonski1, Shashirekha S. Markandaiah1, Dena Jacob1, Ni J. Meng1, Ke Li2, Victoria Gennaro1, Angelo

77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... Comment on Surplus Property Release at Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation... J Smith Field, be used for aeronautical purposes. DATES: Comments must be received on or before June... property at the Michael J Smith Field. The property consists of one parcel located on the north side of...

Michael Faraday on the Learning of Science and Attitudes of Mind.

ERIC Educational Resources Information Center

Crawford, Elspeth

1998-01-01

Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors

PubMed Central

Men, Ruizhi; Li, Ning; Ding, Chihong; Tang, Yingzhan; Xing, Yachao; Ding, Wanjing; Ma, Zhongjun

2016-01-01

Background: The fruits of some varieties of genus Physalis have been used as delicious fruits and functional food in the Northeast of China. Materials and Methods: To reveal the functional material basis, we performed bioactivity-guided phytochemical research and chemopreventive effect assay of the constituents from Physalis minima. Results: It was demonstrated that the ethyl acetate extract of P. minima L. (EEPM) had potential quinone reductase (QR) inducing activity with induction ratio (IR, QR induction activity) value of 1.47 ± 0.24, and glutathione binding property as potential Michael reaction acceptors (with an α, β-unsaturated ketone moiety). Furthermore, bioactivity-guided phytochemical research led eight compounds (1–8), which were elucidated as 3-isopropyl-5-acetoxycyclohexene-2-one-1 (1), isophysalin B (2), physalin G (3), physalin D (4), physalin I (5), physordinose B (6), stigmasterol-3-O-β-D-glucopyranoside (7) and 5α-6β-dihydroxyphysalin R (8) on the basis of nuclear magnetic resonance spectroscopy analyses and HRESIMS. Then, isophysalin B (2) and physordinose B (6) showed significant QR inducing activity with IR value of 2.80 ± 0.19 and 2.38 ± 0.46, respectively. SUMMARY An ultra-performance liquid chromatographic method with glutathione as the substrate was used to detect the Michael reaction acceptors in extracts of Physalis minima (EPM)We investigated the chemical constituents of EPM guided by biological activity methodIsophysalin B (1) and physordinose B (6) showed strong quinone reductase inducing activity with induction ratio values of 2.80 ± 0.19 and 2.38 ± 0.46This study generated useful information for consumers and many encourage researchers to utilize edible fruits from Physalis as a source of phytochemicals Abbreviations used: EPM: Extracts of Physalis minima, EEPM: Ethyl acetate extract of Physalis minima L., GSH: Glutathione, MRAs: Michael reaction acceptors, QR: Quinone reductase. PMID:27279713

Michael Young's "The Rise of the Meritocracy": A Philosophical Critique

ERIC Educational Resources Information Center

Allen, Ansgar

2011-01-01

This paper examines Michael Young's 1958 dystopia, "The Rise of the Meritocracy". In this book, the word "meritocracy" was coined and used in a pejorative sense. Today, however, meritocracy represents a positive ideal against which we measure the justice of our institutions. This paper argues that, when read in the twenty-first century, Young's…

On Happiness and High Achievement: An Interview with Michael Thompson

ERIC Educational Resources Information Center

National Association of Independent Schools (NAIS) (NJ), 2006

2006-01-01

Michael G. Thompson knows independent schools. He attended them in elementary and secondary school, and has worked in them as a psychologist. He consults with more than 30 schools a year, addressing a myriad of issues related to complex human interaction. He has written often in "Independent School" about everything from understanding the social…

Passings to note: Paul Michael Packman, MD; S. Charles Schulz, MD.

PubMed

Black, Donald W

2018-02-01

One of the keys to the success of Annals of Clinical Psychiatry has always been the tireless efforts of our dedicated Editorial Board. We recently lost 2 longtime Editorial Board members, Drs. Paul Michael Packman and S. Charles Schulz. Both will be greatly missed.

Shaping the Global Civil Society: An Interview with Michael Peters

ERIC Educational Resources Information Center

Heraud, Richard; Tesar, Marek

2017-01-01

Professor Michael A. Peters has worked in an era of transformation that has taken him from a labour-intensive paper-based form of production to the computerised reproduction of thought, and the current shift in the publishing landscape from a reader-subscription to an author-pays model. Most of what he has learned in publishing and editing he has…

Michael E. Barnes: Award for Distinguished Professional Contributions to Institutional Practice

ERIC Educational Resources Information Center

American Psychologist, 2012

2012-01-01

Presents a short biography on the winner of the American Psychological Association's Award for Distinguished Professional Contributions to Institutional Practice. The 2012 winner is Michael E. Barnes for his pioneering leadership, dedication, and distinguished contributions to juvenile justice. As chief psychologist of the Superior Court of the…

76 FR 21406 - Michael J. Aruta, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-40] Michael J. Aruta, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration published the above-titled Decision and Order, as well as the Decision of the Administrative Law Judge (76...

Q & A with Ed Tech Leaders: Interview with J. Michael Spector

ERIC Educational Resources Information Center

Shaughnessy, Michael F.; Fulgham, Susan M.

2015-01-01

J. Michael Spector's academic preparation was in philosophy--epistemology and logic, primarily. His dissertation was on skepticism in modern philosophy, and that led him to a deep-seated appreciation for classical skepticism. The word "skeptic" is derived from the Greek word "skepsis," which means investigation. While the…

The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

PubMed

Dell, M

1998-01-01

Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age.

Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

PubMed

2011-11-01

Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved). 2011 APA, all rights reserved

Synthesis of pyroglutamic acid derivatives via double michael reactions of alkynones.

PubMed

Scansetti, Myriam; Hu, Xiangping; McDermott, Benjamin P; Lam, Hon Wai

2007-05-24

In the presence of substoichiometric quantities of potassium tert-butoxide and an additional metal salt, amide-tethered diacids undergo double Michael reactions with alkynones to provide highly functionalized pyroglutamic acid derivatives. The metal salt was found to play an important role in improving the diastereoselectivities of the reactions.

Broadening the Debate: Comments on Michael J. Feuer's "Moderating the Debate"

ERIC Educational Resources Information Center

Robertson, Emily

2009-01-01

In "Moderating the Debate: Rationality and the Promise of American Education", Michael Feuer argues that insights from cognitive science and the theory of bounded rationality can help us understand why educational policy makers overreach in seeking optimal solutions to educational problems. In this essay, Emily Robertson argues that cognitive…

A celebration of mechanics: from nano to macro. The J. Michael T. Thompson Festschrift issue.

PubMed

Elishakoff, Isaac

2013-06-28

This Theme Issue is dedicated to the topic 'Mechanics: from nano to macro' and marks the 75th birthday of Dr J. Michael T. Thompson, Fellow of the Royal Society, whose current affiliations are as follows: (i) Honorary Fellow, Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge; (ii) Emeritus Professor of Nonlinear Dynamics, Department of Civil, Environmental and Geomatic Engineering, University College London; and (iii) Professor of Theoretical and Applied Dynamics (Distinguished Sixth Century Chair, part-time), University of Aberdeen. He also serves as Chairman of the Board of Directors at ES-Consult (consulting engineers) in Copenhagen, Denmark. The pertinent question that arises from the very start is: should we first salute Michael and then describe the Theme Issue, or vice versa? Indeed, according to Blaise Pascal (1623-1662), the last thing one discovers in composing a work is what to put first. I would like to take the liberty of deviating from the tradition of the Philosophical Transactions and start with the tribute to Michael; after all he is the prime cause of this Theme Issue.

Acid-Activatable Michael-Type Fluorescent Probes for Thiols and for Labeling Lysosomes in Live Cells.

PubMed

Dai, Chun-Guang; Du, Xiao-Jiao; Song, Qin-Hua

2015-12-18

A Michael addition is usually taken as a base-catalyzed reaction. Most fluorescent probes have been designed to detect thiols in slightly alkaline solutions (pH 7-9). The sensing reactions of almost all Michael-type fluorescent probes for thiols are faster in a high pH solution than in a low pH solution. In this work, we synthesized a series of 7-substituted 2-(quinolin-2-ylmethylene)malonic acids (QMAs, substituents: NEt2, OH, H, Cl, or NO2) and their ethyl esters (QMEs) as Michael-type fluorescent probes for thiols. The sensing reactions of QMAs and QMEs occur in distinct pH ranges, pH < 7 for QMAs and pH > 7 for QMEs. On the basis of experimental and theoretic studies, we have clarified the distinct pH effects on the sensing reactivity between QMAs and QMEs and demonstrated that two QMAs (NEt2, OH) are highly sensitive and selective fluorescent probes for thiols in acidic solutions (pH < 7) and promising dyes that can label lysosomes in live cells.

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

PubMed

Jackson, Paul A; Widen, John C; Harki, Daniel A; Brummond, Kay M

2017-02-09

Although Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ignored in drug discovery because of their presumed indiscriminate reactivity. As such, a dearth of information exists relevant to the thiol reactivity of natural products and their analogues possessing this moiety. In the midst of recently approved acrylamide-containing drugs, it is clear that a good understanding of the hetero-Michael addition reaction and the relative reactivities of biological thiols with Michael acceptors under physiological conditions is needed for the design and use of these compounds as biological tools and potential therapeutics. This Perspective provides information that will contribute to this understanding, such as kinetics of thiol addition reactions, bioactivities, as well as steric and electronic factors that influence the electrophilicity and reversibility of Michael acceptors. This Perspective is focused on α,β-unsaturated carbonyls given their preponderance in bioactive natural products.

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

PubMed Central

Jackson, Paul A.; Widen, John C.; Harki, Daniel A.; Brummond, Kay M.

2017-01-01

Although Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ignored in drug discovery because of their presumed indiscriminate reactivity. As such, a dearth of information exists relevant to the thiol reactivity of natural products and their analogs possessing this moiety. In the midst of recently approved acrylamide-containing drugs, it is clear that a good understanding of the hetero-Michael addition reaction and the relative reactivities of biological thiols with Michael acceptors under physiological conditions is needed for the design and use of these compounds as biological tools and potential therapeutics. This perspective provides information that will contribute to this understanding, such as kinetics of thiol addition reactions, bioactivities, as well as steric and electronic factors that influence the electrophilicity and reversibility of Michael acceptors. This perspective is focused on α,β-unsaturated carbonyls given their preponderance in bioactive natural products. PMID:27996267

An Integral Part of the Frederick Community—Michael Dean | Poster

Cancer.gov

For more than 30 years, Michael Dean, Ph.D., has been an integral part of the NCI at Frederick community. In addition to studying several different aspects of genomics and cancer research, he has worked with the Werner H. Kirsten Student Intern Program and also volunteered his time with Mission of Mercy, a community-based organization providing free healthcare and free

C. P. Snow's "The Two Cultures": Michael Polanyi's Response and Context

ERIC Educational Resources Information Center

Jacobs, Struan

2011-01-01

C. P. Snow's "The Two Cultures" controversially contrasted science and literature, suggesting that neither scientists nor literary intellectuals have much in common with, and seldom bother speaking to, the other. Responding to Snow, Michael Polanyi argued that specialization has made modern culture, not twofold but manifold. In his major work,…

The children's republic of science in the antebellum literature of Samuel Griswold Goodrich and Jacob Abbott.

PubMed

Pandora, Katherine

2009-01-01

The antebellum years in the United States were marked by vigorous debates about national identity in which issues of hierarchy, authority, and democratic values came under intense scrutiny. During this period, a prime objective of indigenous authors writing for American children was educating the young so they would be ready to assume their republican responsibilities. The question of how depictions and discussions about nature and science were deployed toward this end is explored by examining key texts about nature and science from the era's two most prolific and popular children's authors--Samuel Griswold Goodrich (1793-1860) and Jacob Abbott (1803-79)--and highlighting assumptions within these works about what the proper relationship should be between the search for scientific knowledge and the larger polity.

Little Mosie from the Margaree: A Biography of Moses Michael Coady.

ERIC Educational Resources Information Center

Welton, Michael R.

This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

Michael Duane after Risinghill: Rise and Fall of an Educational Celebrity

ERIC Educational Resources Information Center

Limond, David

2005-01-01

In this article an attempt is made to examine the continuing implications of the operation and closure of London's Risinghill school, a co-educational comprehensive extant from 1960 to 1965. It is suggested that Risinghill's controversial headteacher, Michael Duane (1915-1997), was an educational celebrity and folk hero amongst teachers and in…

Astronaut C. Michael Foale is briefed on use of Sky Genie

NASA Technical Reports Server (NTRS)

1994-01-01

Astronaut C. Michael Foale, STS-63 mission specialist, is briefed on the use of Sky Genie device by Karin L. Porter. The device would aid in emergency egress operations aboard a troubled Space Shuttle. Porter, an employee of Rockwell International, helps train astronauts in egress procedures at JSC's Shuttle mockup and integration laboratory.

Mission Specialist Michael Lopez-Alegria changes out film in camera

NASA Image and Video Library

1995-11-05

STS073-335-009 (20 October-5 November 1995) --- Astronaut Michael E. Lopez-Alegria, STS-73 mission specialist, changes the film in a 35mm camera on the flight deck of the Earth-orbiting Space Shuttle Columbia. Alegria joined four other NASA astronauts and two guest researchers for almost 16-days of Earth-orbit research in support of the U.S. Microgravity Laboratory (USML-2) mission.

A Critical Analysis of Michael Tippett's "A Child of Our Time"

ERIC Educational Resources Information Center

Vallee, Jean-Sebastien

2009-01-01

After more than ten years of thoughtful planning, Michael Tippett (1905-1998) summed up his musical, political, spiritual and philosophical beliefs in his first oratorio, "A Child of Our Time" (1941). Representing the emergence of a new level of confidence and musical maturity for Tippett, the oratorio has become the composer's most widely known…

Gulliver's Travels: Michael Moore the Explorer in "Who to Invade Next"

ERIC Educational Resources Information Center

Beck, Bernard

2016-01-01

America is identified as a nation of immigrants. These immigrants are thought to be the source of its subcultures. It is also a nation of individual explorers and inventors. Their activities are also a source of diverse subcultures. Many notable movies have made heroes of such innovators in different fields of endeavor. Michael Moore's movie…

Moral Education and Education in Altruism: Two Replies to Michael Hand

ERIC Educational Resources Information Center

White, John

2016-01-01

This article is a critical discussion of two recent papers by Michael Hand on moral education. The first is his "Towards a Theory of Moral Education", published in the "Journal of Philosophy of Education" in 2014 (Volume 48, Issue 4). The second is a chapter called "Beyond Moral Education?" in an edited book of new…

An Interview with Michael Horn: Blending Education for High-Octane Motivation

ERIC Educational Resources Information Center

Patterson, Gregory A.

2012-01-01

Blended learning holds the potential of improving the way we educate students and of making them more motivated. Blended education--the melding of information technology based distance learning with school attendance--is perhaps the best way to educate students for 21st century skills, says Michael Horn in a "Kappan" interview. Horn points out…

NASA Dryden test pilot Michael J. Adams

NASA Image and Video Library

1967-03-22

Air Force test pilot Maj. Michael J. Adams stands beside X-15 ship number one. Adams was selected for the X-15 program in 1966 and made his first flight on Oct. 6, 1966. On Nov. 15, 1967, Adams made his seventh and final X-15 flight. The X-15 launched from the B-52, but during the ascent an electrical problem affected the X-15's control system. The aircraft crashed northwest of Cuddeback Lake, California, causing the death of Adams. He was posthumously awarded Air Force astronaut wings because his final flight exceeded 50 miles in altitude. Adams was the only pilot lost in the 199-flight X-15 program.

Q & A with Ed Tech Leaders: Interview with Michael W. Allen

ERIC Educational Resources Information Center

Shaughnessy, Michael F.

2014-01-01

Michael W. Allen, the Chairman and CEO of Allen Interactions, is an architect of interactive multimedia learning and is recognized for his many insights, inventions, and presentations. With over 50 years of experience in e-learning, both in academic and corporate settings, he is known for his role in creating Authorware and overseeing the work of…

Irish Education for the 21st Century. Michael Enright Commemorative Project.

ERIC Educational Resources Information Center

Ward, Noel, Ed.; Dooney, Triona, Ed.

The essays in this collection contribute to the ongoing discussion about the state of Irish education on the threshold of a new century. The various contributors examine issues that will be priorities for education planners in Ireland. These essays have been collected as a tribute to Irish educator and politician Michael Enright. The essays are:…

The Benevolent Technocrat: Michael Dukakis' Strategy in the 1988 Presidential Debates.

ERIC Educational Resources Information Center

Herbeck, Dale A.

Michael Dukakis lost the presidential campaign debates of 1988 (or at least failed to capitalize as much as he might have) because he understood the debates to be genuine debates. Consequently, Dukakis acted as a debater generating an image of himself as a "benevolent technocrat," which was an error. It must be pointed out that the…

Michael F. Vaccaro Honors Attorney Fellowship Program in our Philadelphia (Region 3) Office

EPA Pesticide Factsheets

The Michael F. Vaccaro Honors Attorney Fellowship provides a unique opportunity to practice law in a major governmental environmental organization, and to receive extensive training in and exposure to environmental law and policy work in the public sector.

An Integral Part of the Frederick Community—Michael Dean | Poster

Cancer.gov

For more than 30 years, Michael Dean, Ph.D., has been an integral part of the NCI at Frederick community. In addition to studying several different aspects of genomics and cancer research, he has worked with the Werner H. Kirsten Student Intern Program and also volunteered his time with Mission of Mercy, a community-based organization providing free healthcare and free prescription medications to the uninsured and under-insured.

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.

PubMed

Zheng, Suqing; Santosh Laxmi, Y R; David, Emilie; Dinkova-Kostova, Albena T; Shiavoni, Katherine H; Ren, Yanqing; Zheng, Ying; Trevino, Isaac; Bumeister, Ronald; Ojima, Iwao; Wigley, W Christian; Bliska, James B; Mierke, Dale F; Honda, Tadashi

2012-05-24

Novel monocyclic cyanoenones examined to date display unique features regarding chemical reactivity as Michael acceptors and biological potency. Remarkably, in some biological assays, the simple structure is more potent than pentacyclic triterpenoids (e.g., CDDO and bardoxolone methyl) and tricycles (e.g., TBE-31). Among monocyclic cyanoenones, 1 is a highly reactive Michael acceptor with thiol nucleophiles. Furthermore, an important feature of 1 is that its Michael addition is reversible. For the inhibition of NO production, 1 shows the highest potency. Notably, its potency is about three times higher than CDDO, whose methyl ester (bardoxolone methyl) is presently in phase III clinical trials. For the induction of NQO1, 1 also demonstrated the highest potency. These results suggest that the reactivity of these Michael acceptors is closely related to their biological potency. Interestingly, in LPS-stimulated macrophages, 1 causes apoptosis and inhibits secretion of TNF-α and IL-1β with potencies that are higher than those of bardoxolone methyl and TBE-31.

Theory and practice in action: the contributions of Michael Perkins to clinical linguistics.

PubMed

Damico, Jack S; Lynch, Karen E

2013-01-01

This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.

From Gouldner to Gramsci: The Making of Michael Apple's "Ideology and Curriculum"

ERIC Educational Resources Information Center

Gottesman, Isaac

2012-01-01

Michael Apple's "Ideology and Curriculum", published in 1979, helped initiate a broad turn in the field of education in the United States to Marxist thought as a lens through which to analyze the relationship between school and society. This classic text continues to inform scholarship in the field. While "Ideology" has…

Highlighting High Performance: Michael E. Capuano Early Childhood Center; Somerville, Massachusetts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2006-03-01

This brochure describes the key high-performance building features of the Michael E. Capuano Early Childhood Center. The brochure was paid for by the Massachusetts Technology Collaborative as part of their Green Schools Initiative. High-performance features described are daylighting and energy-efficient lighting, indoor air quality, solar and wind energy, building envelope, heating and cooling systems, water conservation, and acoustics. Energy cost savings are also discussed.

A tribute to Michael R. Raupach for contributions to aeolian fluid dynamics

USDA-ARS?s Scientific Manuscript database

Since the early work of Bagnold in the 1940s, aeolian research has grown to become a major integral part of earth-system studies. Many individuals have contributed to this development, and Dr. Michael R. Raupach (MR2, 1950 – 2015) was one of the most outstanding. MR2 worked for about a decade (1985 ...

Schools as "Poetry-Friendly Places": Michael Rosen on Poetry in the Curriculum

ERIC Educational Resources Information Center

Xerri, Daniel

2014-01-01

This article explores the views of children's poet Michael Rosen in relation to poetry in education. It is based on an interview in which Rosen not only discusses the significance of encouraging young people to engage with poetry at school but also analyzes a number of threats to poetry's place in the English curriculum. This article identifies…

Michael Maier--nine newly discovered letters.

PubMed

Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

2014-02-01

The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

STS-69 MS Michael L. Gernhardt greets his mother at SLF

NASA Technical Reports Server (NTRS)

1995-01-01

STS-69 Mission Specialist Michael L. Gernhardt (right) gets a chance to say hi to his mother, Suzanne Winters, and her husband Doug, after the STS-69 flight crew arrived at KSC's Shuttle Landing Facility. The five astronauts assigned to the mission are looking forward to a liftoff aboard the Space Shuttle Endeavour during a two and a half hour window opening at 11:09 a.m. EDT, Sept. 7.

The Politics of Education Revisited: Anthony Crosland and Michael Gove in Historical Perspective

ERIC Educational Resources Information Center

Finn, Mike

2015-01-01

This article traces continuity and change in the governance of British education through the comparison of two ministers, Anthony Crosland and Michael Gove. Taking Maurice Kogan's seminal "The Politics of Education" as the point of departure, the article highlights the role of political ideology in large-scale educational change, taking…

Neuroscientific Investigator of High Mathematical Ability: An Interview with Michael W. O'Boyle

ERIC Educational Resources Information Center

Kalbfleisch, M. Layne

2008-01-01

This article presents an interview with Michael W. O'Boyle, a neuroscientific investigator of high mathematical ability. O'Boyle is a professor in the Department of Human Development and Family Studies, Texas Tech University, and Adjunct Professor of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center.…

Toward a Global Vision of Gifted Education: An Interview with Michael S. Matthews

ERIC Educational Resources Information Center

Henshon, Suzanna E.

2017-01-01

Dr. Michael S. Matthews is professor and director of the Academically & Intellectually Gifted graduate programs at the University of North Carolina at Charlotte. He is incoming Coeditor of the "Gifted Child Quarterly" and a member of the Board of Directors of the National Association for Gifted Children. Dr. Matthews also currently…

The Journey Is the Film Is the Journey: Michael Winterbottom's "In This World"

ERIC Educational Resources Information Center

Farrier, David

2008-01-01

This essay examines Michael Winterbottom's 2002 film "In This World," which follows the journey of two Afghan migrants from Peshawar to London. Winterbottom's preparation involved travelling from London to Peshawar and then in reverse overland as far as Istanbul; he then returned to Peshawar and filmed the same journey using two…

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.

PubMed

Maucher, Isabelle V; Rühl, Michael; Kretschmer, Simon B M; Hofmann, Bettina; Kühn, Benjamin; Fettel, Jasmin; Vogel, Anja; Flügel, Karsten T; Manolikakes, Georg; Hellmuth, Nadine; Häfner, Ann-Kathrin; Golghalyani, Vahid; Ball, Ann-Katrin; Piesche, Matthias; Matrone, Carmela; Geisslinger, Gerd; Parnham, Michael J; Karas, Michael; Steinhilber, Dieter; Roos, Jessica; Maier, Thorsten J

2017-02-01

Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting catalytically with cysteine residues next to a substrate entry channel. The electrophilicity is derived from an intramolecular Michael acceptor moiety consisting of an electron-withdrawing group in close proximity to a double bond. The potential of the Michael acceptor moiety to interact with functionally relevant cysteines of proteins potentially renders them effective and sustained enzyme activity modulators. We screened a large library of naturally derived and synthetic electrophilic compounds to investigate whether other types of Michael acceptor containing drugs suppress 5-LO enzyme activity. The activity was measured by assessing the effect on the 5-LO product formation of intact human polymorphonuclear leukocytes. We demonstrated that a number of structurally different compounds were suppressive in the activity assays and showed that Michael acceptors of the quinone and nitro-alkene group produced the strongest inhibition of 5-LO product formation. Reactivity with the catalytically relevant cysteines 416 and 418 was confirmed using mutated recombinant 5-LO and mass spectrometric analysis (MALDI-MS). In the present study, we show for the first time that a number of well-recognized naturally occurring or synthetic anti-inflammatory compounds carrying a Michael acceptor, such as thymoquinone (TQ), the paracetamol metabolite NAPQI, the 5-LO inhibitor AA-861, and bardoxolone methyl (also known as RTA 402 or CDDO-methyl ester) are direct covalent 5-LO enzyme inhibitors that target the catalytically relevant cysteines 416 and 418. Copyright © 2016 Elsevier Inc. All rights reserved.

The wonderful apparatus of John Jacob Abel called the "artificial kidney".

PubMed

Eknoyan, Garabed

2009-01-01

Hemodialysis, which now provides life-saving therapy to millions of individuals, began as an exploratory attempt to sustain the lives of selected patients in the 1950s. That was a century after the formulation of the concept and determination of the laws governing dialysis. The first step in the translation of the laboratory principles of dialysis to living animals was the "vividiffusion" apparatus developed by John Jacob Abel (1859-1938), dubbed the "artificial kidney" in the August 11, 1913 issue of The Times of London reporting the demonstration of vividiffusion by Abel at University College. The detailed article in the January 18, 1914 of the New York Times, reproduced here, is based on the subsequent medical reports published by Abel et al. Tentative attempts of human dialysis in the decade that followed based on the vividiffusion apparatus of Abel and his materials (collodion, hirudin, and glass) met with failure and had to be abandoned. Practical dialysis became possible in the 1940s and thereafter after cellophane, heparin, and teflon became available. Abel worked in an age of great progress and experimental work in the basic sciences that laid the foundations of science-driven medicine. It was a "Heroic Age of Medicine," when medical discoveries and communicating them to the public were assuming increasing importance. This article provides the cultural, social, scientific, and medical background in which Abel worked, developed and reported his wonderful apparatus called the "artificial kidney."

What Work Do the Concepts of "Language" and "Literature" Do for Michael Rosenak?

ERIC Educational Resources Information Center

Levisohn, Jon A.

2014-01-01

Michael Rosenak uses the twin metaphors of "language" and "literature," borrowed from Oakeshott and Peters, to argue that the goal of education is initiation into a language. This goal transcends the study of literature in that language. It includes, as well, the development of the capacity both to critique literature and to…

Subjectivity and Cultural Adjustment in Mathematics Education: A Response to Wolff-Michael Roth

ERIC Educational Resources Information Center

Brown, Tony

2012-01-01

In this volume, Wolff-Michael Roth provides a critical but partial reading of Tony Brown's book "Mathematics Education and Subjectivity". The reading contrasts Brown's approach with Roth's own conception of subjectivity as derived from the work of Vygotsky, in which Roth aims to "reunite" psychology and sociology. Brown's book, however, focuses on…

Development of a Fragment-Based in Silico Profiler for Michael Addition Thiol Reactivity.

PubMed

Ebbrell, David J; Madden, Judith C; Cronin, Mark T D; Schultz, Terry W; Enoch, Steven J

2016-06-20

The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adverse effect. An important example of a well-defined MIE is the formation of a covalent bond between a biological nucleophile and an electrophilic compound. This particular MIE has been associated with various toxicological end points such as acute aquatic toxicity, skin sensitization, and respiratory sensitization. This study has investigated the calculated parameters that are required to predict the rate of chemical bond formation (reactivity) of a dataset of Michael acceptors. Reactivity of these compounds toward glutathione was predicted using a combination of a calculated activation energy value (Eact, calculated using density functional theory (DFT) calculation at the B3YLP/6-31G+(d) level of theory, and solvent-accessible surface area values (SAS) at the α carbon. To further develop the method, a fragment-based algorithm was developed enabling the reactivity to be predicted for Michael acceptors without the need to perform the time-consuming DFT calculations. Results showed the developed fragment method was successful in predicting the reactivity of the Michael acceptors excluding two sets of chemicals: volatile esters with an extended substituent at the β-carbon and chemicals containing a conjugated benzene ring as part of the polarizing group. Additionally the study also demonstrated the ease with which the approach can be extended to other chemical classes by the calculation of additional fragments and their associated Eact and SAS values. The resulting method is likely to be of use in regulatory toxicology tools where an understanding of covalent bond formation as a potential MIE is important within the AOP paradigm.

A Response to Michael W. Apple's "Theory, Research, and the Critical Scholar/Activist"

ERIC Educational Resources Information Center

Leonardo, Zeus

2010-01-01

Michael Apple's prescient review of Anyon et al.'s "Theory and Educational Research" reminds the educational community of the importance of purpose. In his own work, he has been consistent in--actually, insistent on--emphasizing the struggle over political projects. This is not an issue concerning only the Left as the scapegoat for the disparaging…

N719 dye-sensitized organophotocatalysis: enantioselective tandem Michael addition/oxyamination of aldehydes.

PubMed

Yoon, Hyo-Sang; Ho, Xuan-Huong; Jang, Jiyeon; Lee, Hwa-Jung; Kim, Seung-Joo; Jang, Hye-Young

2012-07-06

A remarkably efficient photosensitizer, N719 dye, was used in asymmetric tandem Michael addition/oxyamination of aldehydes, rendering α,β-substituted aldehydes in good yields with excellent levels of enantioselectivity and diastereoselectivity. This is the first report of a multiorganocatalytic reaction involving iminium catalysis and photoinduced singly occupied molecular orbital (SOMO) catalysis. This reaction is expected to expand the scope of tandem organocatalytic reactions.

[The problem of evil in families--the filmmaker Michael Haneke].

PubMed

Skårderud, Finn

2010-09-23

With the beautiful and dark film "The white ribbon", from 2009, the Austrian film director Michael Haneke consolidated his status as an international success. A central theme in his films is evilness and its roots. But just as important is his ambition to develop films where evil is not only portrayed, but where spectators are challenged to relate to their own ethical standards and their role as spectators. Haneke is a highly original filmmaker with his consistent search for a film aesthetic that stimulates ethical self-reflection and mentalizing. He partly succeeds in this quest.

Training and Mastery of Techniques in Wittgenstein's Later Philosophy: A Response to Michael Luntley

ERIC Educational Resources Information Center

Stickney, Jeff

2008-01-01

Responding to Michael Luntley's article, "Learning, Empowerment and Judgement," the author shows he cannot successfully make the following three moves: (1) dissolve the analytic distinction between learning by training and learning by reasoning, while advocating the latter; (2) diminish the role of training in Wittgenstein's philosophy, nor…

The Data on Children's Media Use: An Interview with Michael Robb

ERIC Educational Resources Information Center

Heller, Rafael

2018-01-01

Since 2003, nonprofit organization Common Sense Media has studied the ways in which kids are growing up in the digital age. In this interview, research director Michael Robb shares recent findings about the media habits of young children, tweens, and teens. While the news coverage of these issues tends to be hyperbolic and alarming, Robb explains,…

The Educational Philosophies of Mordecai Kaplan and Michael Rosenak: Surprising Similarities and Illuminating Differences

ERIC Educational Resources Information Center

Schein, Jeffrey; Caplan, Eric

2014-01-01

The thoughts of Mordecai Kaplan and Michael Rosenak present surprising commonalities as well as illuminating differences. Similarities include the perception that Judaism and Jewish education are in crisis, the belief that Jewish peoplehood must include commitment to meaningful content, the need for teachers to teach from a position of…

Obituary: Michael John Klein, 1940-2005

NASA Astrophysics Data System (ADS)

Gulkis, Samuel

2006-12-01

Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

Evaluation of GPS Coverage for the X-33 Michael-6 Trajectory

NASA Technical Reports Server (NTRS)

Lundberg, John B.

1998-01-01

The onboard navigational system for the X-33 test flights will be based on the use of measurements collected from the Embedded Global Positioning System (GPS)/INS system. Some of the factors which will affect the quality of the GPS contribution to the navigational solution will be the number of pseudorange measurements collected at any instant in time, the distribution of the GPS satellites within the field of view, and the inherent noise level of the GPS receiver. The distribution of GPS satellites within the field of view of the receiver's antenna will depend on the receiver's position, the time of day, pointing direction of the antenna, and the effective cone angle of the antenna. The number of pseudorange measurements collected will depend upon these factors as well as the time required to lock onto a GPS satellite signal once the GPS satellite comes into the field of view of the antenna and the number of available receiver channels. The objective of this study is to evaluate the GPS coverage resulting from the proposed antenna pointing directions, the proposed antenna cone angles, and the effects due to the time of day for the X-33 Michael-6 trajectory from launch at Edwards AFB, California, to the start of the Terminal Area Energy Management (TAEM) phase on approach to Michael AAF, Utah.

Enantioselective Michael Addition of Pyrroles with Nitroalkenes in Aqueous Media Catalyzed by a Water-soluble Catalyst.

PubMed

Gui, Yang; Li, Yanan; Sun, Jianan; Zha, Zhenggen; Wang, Zhiyong

2018-06-11

A new water-soluble catalytic system were developed and therefor used in an enantioselective Michael addition of pyrroles with nitroalkenes in water to afford the nitroethylpyrrole derivatives with both excellent yields and ee values.

"Raising Standards" or Reducing Aspirations and Opportunities Still Further? Michael Gove and Examination Reforms

ERIC Educational Resources Information Center

Allen, Martin

2013-01-01

Well before the examinations grade crisis of 2012, Michael Gove had set out clear intentions for reforming public examinations. Though he claimed to be improving examinations and assessment by replicating practices that took place in high-performing countries and thus improving the ability of the UK economy to "compete", this…

Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

NASA Astrophysics Data System (ADS)

Brendel, Michelle

2014-12-01

Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

Michael's Inform Test of Student Ability (M.I.T.O.S.A.). Tester's Manual.

ERIC Educational Resources Information Center

Grafius, Thomas M.

Michael's Informal Test of Student Ability (MITOSA) is a diagnostic evaluative tool for adult students designed to test nine skills abilities in adult students functioning below a tenth grade level. The nine test sections are approximate reading level, understanding of basic math concepts and symbols, general thinking/reasoning ability, eye-hand…

Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-aza-Michael Addition Reaction.

PubMed

Wang, Juan; Yang, Hu

2018-05-08

Dendrimers exhibit super atomistic features by virtue of their well-defined discrete quantized nanoscale structures. Here, we show that hyperbranched amine-terminated polyamidoamine (PAMAM) dendrimer G4.0 reacts with linear polyethylene glycol (PEG) diacrylate (575 g/mol) via the aza-Michael addition reaction at a subzero temperature (-20 °C), namely cryo-aza-Michael addition, to form a macroporous superelastic network, i.e., dendrimer cryogel. Dendrimer cryogels exhibit biologically relevant Young's modulus, high compression elasticity and super resilience at ambient temperature. Furthermore, the dendrimer cryogels exhibit excellent rebound performance and do not show significant stress relaxation under cyclic deformation over a wide temperature range (-80 to 100 °C). The obtained dendrimer cryogels are stable at acidic pH but degrade quickly at physiological pH through self-triggered degradation. Taken together, dendrimer cryogels represent a new class of scaffolds with properties suitable for biomedical applications.

New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts

PubMed Central

2012-01-01

Abstract Two efficient reactions were successfully carried out using Animal Bone Meal (ABM) and potassium fluoride or sodium nitrate doped ABMs as new heterogeneous catalysts under very mild conditions. After preparation and characterization of the catalysts, we first report their use in a simple and convenient synthesis of various chalcones by Claisen–Schmidt condensation and then in an aza-Michael addition involving several synthesized chalcones with aromatic amines. All the reactions were carried out at room temperature in methanol; the chalcone synthesis was also achieved in water environment under microwave irradiation. Doping ABM enhances the rate and yield at each reaction. Catalytic activities are discussed and the ability to re-use the ABM is demonstrated. Results For Claisen–Schmidt the use of ABM alone, yields never exceeded 17%. In each entry, KF/ABM and NaNO3/ABM (79-97%) gave higher yields than using ABM alone under thermic condition. Also the reaction proceeded under microwave irradiation in good yields (72-94% for KF/ABM and 81-97% for NaNO3/ABM) and high purity. For aza-Michael addition the use of ABM doped with KF or NaNO3 increased the catalytic activity remarkably. The very high yields could be noted (84-95% for KF/ABM and 81-94% for NaNO3/ABM). Conclusion The present method is an efficient and selective procedure for the synthesis of chalcones an aza-Michael adducts. The ABM and doped ABMs are a new, inexpensive and attractive solid supports which can contribute to the development of catalytic processes and reduced environmental problems. PMID:22721409

STS-109 Crew Interviews: Michael J. Massimino

NASA Technical Reports Server (NTRS)

2002-01-01

STS-109 Mission Specialist Michael J. Massimino is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, and his most memorable experiences. He gives details on the mission's goals and objectives, which focus on the refurbishing of the Hubble Space Telescope, and his role in the mission. He explains the plans for the rendezvous of the Columbia Orbiter with the Hubble Space Telescope. He provides details and timelines for each of the planned Extravehicular Activities (EVAs), which include replacing the solar arrays, changing the Power Control Unit, installing the Advanced Camera for Surveys (ACS), and installing a new Cryocooler for the Near Infrared Camera and Multi-Object Spectrometer (NICMOS). He also describes the break-out plan in place for these spacewalks. The interview ends with Massimino explaining the details of a late addition to the mission's tasks, which is to replace a reaction wheel on the Hubble Space Telescope.

The extraordinary impact of Michael Faraday on chemistry and related subjects.

PubMed

Thomas, John Meurig

2017-08-25

Biographers of Michael Faraday, as well as many dictionaries of science, often describe him as a physicist, which he certainly was. But he was also an astonishingly effective chemist: in fact, he was the Fullerian Professor of Chemistry (at the Royal Institution, RI) from 1834 until the time of his death in August, 1867. To mark the sesquicentenary of his passing, this editorial, by one of his distant successors as Director and Fullerian Professor at the RI, focuses on Faraday's output and influence as a scientist.

Gender Relations and Sexual Harassment in the Workplace: Michael Crichton's "Disclosure" as a Teaching Tool.

ERIC Educational Resources Information Center

Comer, Debra R.; Cooper, Elizabeth A.

1998-01-01

Describes how to use Michael Crichton's novel "Disclosure" and the film based on it for class discussions of such issues as what constitutes sexual harassment, harassment of men, relationship between sexual harassment and power, organizational responses to harassment, and gender differences in career advancement tactics. (SK)

Double hetero-Michael addition of N-substituted hydroxylamines to quinone monoketals: synthesis of bridged isoxazolidines.

PubMed

Yin, Zhiwei; Zhang, Jinzhu; Wu, Jing; Liu, Che; Sioson, Kate; Devany, Matthew; Hu, Chunhua; Zheng, Shengping

2013-07-19

A general synthesis of bridged isoxazolidines from a double hetero-Michael addition of N-substituted hydroxylamines to quinone monoketals has been developed. The different addition order of N-benzylhydroxylamine and N-Boc hydroxylamine is also discussed. Moreover, the various functionalities in the isoxazolidine products allow facile derivatization.

David Cozad, Michael Schumacher and/or Brad Peterson (d/b/a Credit Island Recycling), Davenport, Iowa

EPA Pesticide Factsheets

The EPA is providing notice of proposed Administrative Penalty Assessment against David Cozad, Michael Schumacher and/or Brad Peterson (d/b/a Credit Island Recycling), for alleged violations of an industrial stormwater permit issued by IDNR for an applianc

Dr Michaels® product family (also branded as Soratinex®) versus Methylprednisolone aceponate - a comparative study of the effectiveness for the treatment of plaque psoriasis.

PubMed

Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

2016-01-01

As one of the most common dermatologic chronic-recurrent disease, variable therapeutic options are available today for management of psoriasis. Although topical high potency corticosteroids, alone or in association with salicylic acid or vitamin D analogues, are still considered the best treatment, they do not seem to possess the capability for a long-term control of the disease or prevent recurrences, as their side effects are major contraindications for continuative use. The aim of this study was to investigate whether Dr. Michaels® product family is comparable to methylprednisolone aceponate (MPA) as a viable alternative treatment option for the treatment and management of stable chronic plaque psoriasis. Thirty adults (13 male, 17 female, mean age 40 years) with mild to severe stable chronic plaque psoriasis, were included in the study. Patients were advised to treat the lesions of the two sides of their body (left and right) with two different unknown modalities for 8 weeks; the pack of Dr. Michaels® products on the left side (consisting of a cleansing gel, an ointment and a skin conditioner) and a placebo pack on the right side, consisting of a cleansing gel, methylprednisolone ointment and a placebo conditioner. Assessment was done using the Psoriasis Activity Severity Index (PASI) scores before treatment and after 2, 4, 6 and 8 weeks. The results achieved with the Dr. Michaels® (Soratinex®) product family for the treatment of chronic plaque psoriasis were better than the results achieved with methylprednisolone aceponate (MPA), even though quicker resolution was achieved with the steroid with 45% of patients achieving resolution within 8-10 days in comparison to 5-6 weeks in the Dr. Michaels® (Soratinex®) group. Before therapy, the mean PASI score of the LHS in Dr. Michaels® (Soratinex®) group was 13.8±4.1 SD and 14.2±4.2 SD in the RHS methylprednisolone aceponate (MPA) group. After 8 weeks of treatment 62% of the Dr. Michaels® (Soratinex

STS-84 Mission Specialist C. Michael Foale in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist C. Michael Foale prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

Education, Philosophy and Politics: The Selected Works of Michael A. Peters. World Library of Educationalists

ERIC Educational Resources Information Center

Peters, Michael A.

2012-01-01

In the World Library of Educationalists series, international experts themselves compile career-long collections of what they judge to be their finest pieces--extracts from books, key articles, salient research findings, major theoretical and/practical contributions--so the world can read them in a single manageable volume. Michael A. Peters has…

Michael Tuomey's 1848 geological survey of South Carolina

USGS Publications Warehouse

Nystrom, P.G.

1999-01-01

One hundred and fifty years ago, Michael Tuomey completed his 'Report on the Geology of South Carolina,' the result of four years of arduous labor. The report is the first detailed and comprehensive geological description of the entire state, and it includes a geological map that shows the distribution of Coastal Plain and Piedmont-Blue Ridge units. In the sesquicentennial of Tuomey's survey, it is fitting that we recognize his important early contribution to the geology of South Carolina and the southeast. Tuomey's report is a 293-page volume with a 48-page appendix and an index. Although he gave a complete depiction of Coastal Plain geology and delineated Cretaceous, Lower Eocene, Eocene, Miocene, Post-Pliocene, and alluvial units on his map, the emphasis herein is on his mapping of the Piedmont and Blue Ridge. The metamorphic units he delineated are clay slate, mica slate, talcose slate, hornblende slate, gneiss, and lime rock. Gneiss is the most extensive unit on the map. His map shows many elements of the geologic framework we recognize today. The distribution of his clay slate unit corresponds closely with the Carolina slate and Bel Air belts as we know them now. The gneiss between the two clay slate areas matches the Kiokee belt. Areas of mica slate approximate the northern part of the Kings Mountain belt and the Chauga belt. He also recognized that his talcose slate unit was associated with gold deposits. Granitic and basaltic intrusive rocks are also delineated on the map. It shows the Newberry, Columbia, and Liberty Hill granites we recognize today. Basaltic intrusives outlined include the Bush River of western Newberry County, Dutchmans Creek, Big Wateree Creek, and Ogden gabbros. He described the regional extent of diabase dikes as occuring from Virginia to Alabama, noted their preferred direction and diagrammed their near-vertical orientation. He also referred to the distinctive soil and topography that develops on the large gabbros. Michael Tuomey

Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations.

PubMed

Aceña, José Luis; Sorochinsky, Alexander E; Soloshonok, Vadim

2014-09-01

The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of glycine as C-nucleophiles and (b) Ni(II)-complexes of dehydroalanine as Michael acceptors. The first group is significantly larger and consequently subdivided into four chapters based on the source of stereocontrolling element. Thus, a chiral auxiliary can be used as a part of nucleophilic glycine Ni(II) complex, Michael acceptor or both, leading to the conditions of matching vs. mismatching stereochemical preferences. The particular focus of the review is made on the practical aspects of the methodology under discussion and mechanistic considerations.

STS-107 Crew Interviews: Michael Anderson, Mission Specialist

NASA Technical Reports Server (NTRS)

2002-01-01

STS-107 Mission Specialist 3 and Payload Commander Michael Anderson is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. He outlines his role in the mission in general, and specifically in conducting onboard science experiments. He discusses the following instruments and sets of experiments in detail: CM2 (Combustion Module 2), FREESTAR (Fast Reaction Enabling Science Technology and Research, MEIDEX (Mediterranean Israeli Dust Experiment) and MGM (Mechanics of Granular Materials). Anderson also mentions on-board activities and responsibilities during launch and reentry, mission training, and microgravity research. In addition, he touches on the dual work-shift nature of the mission, the use of crew members as research subjects including pre and postflight monitoring activities, the emphasis on crew safety during training and the value of international cooperation.

Theoretical study on the reaction mechanisms of Michael chirality addition between propionaldehyde and nitroalkene catalyzed by an enantioselective catalyst.

PubMed

Zhou, Xinming; Li, Ling; Sun, Xuejun; Wang, Yajun; Du, Dongmei; Fu, Hui

2018-06-01

The asymmetric Michael addition between propionaldehyde and nitroalkene catalyzed by 8-(ethoxycarbonyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid has obtained relatively high yields and excellent enantioselectivities at room temperature. In this study, the molecular structures and optical activity of the most stable conformation I are optimized at B3LYP/6-311++ G(d,p) level. We find that levorotatory conformation I catalyzing the same Michael addition can produce laevo-product A and dextrorotatory conformation I' can obtain the dextral-product A'. These results have guiding significance for further studying on the new chemzymes and the mechanism of the obtained different chiral products. © 2018 Wiley Periodicals, Inc.

Chiral N,N'-Dioxide-Organocatalyzed Regio-, Diastereo- and Enantioselective Michael Addition-Alkylation Reaction.

PubMed

Feng, Juhua; Yuan, Xiao; Luo, Weiwei; Lin, Lili; Liu, Xiaohua; Feng, Xiaoming

2016-10-24

A highly regio-, diastereo- and enantioselective Michael addition-alkylation reaction between α-substituted cyano ketones and (Z)-bromonitrostyrenes has been realized by using a chiral N,N'-dioxide as organocatalyst. A variety of substrates performed well in this reaction, and the corresponding multifunctionalized chiral 2,3-dihydrofurans were obtained in up to 95 % yield with 95:5 dr and 93 % ee. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recollections of Jack Michael and the Application of Skinner's Analysis of Verbal Behavior

ERIC Educational Resources Information Center

Sundberg, Mark L.

2017-01-01

Jack Michael offered a course on verbal behavior almost every year throughout his teaching career. Jack was also interested in the application of Skinner's work and in 1976 began to offer a graduate course at Western Michigan University titled Verbal Behavior Applications. Jack and his students pursued the application of Skinner's work on verbal…

St. Michael's Improvement Program - A Collaborative Approach to Sustainable Cost Savings.

PubMed

Trafford, Anne; Jane, Danielle

2017-01-01

In response to a challenging financial environment and increasing patient demand, St. Michael's Hospital needed to find long-term sustainable solutions to continue to provide high-quality patient care and invest in key priorities. By conducting Operational Reviews in focused areas, the hospital achieved $7.4 million of in-year savings in the first year, found standardizations, process efficiencies and direct cost savings that positioned itself for success in future funding models. Initiatives were grounded in evidence and relied heavily on the effective execution by the leadership, front-line staff and physicians. As organizations face similar challenges, this journey can provide key learnings.

Invited Commentary: Continuing to Loosen the Constraints on Epidemiology in an Age of Change-A Comment on McMichael's "Prisoners of the Proximate".

PubMed

Galea, Sandro

2017-06-01

Published in 1999, McMichael's "Prisoners of the Proximate: Loosening the Constraints on Epidemiology in an Age of Change" (Am J Epidemiol. 1999;149(10):887-897) outlined an exciting vision for epidemiology as the field that that can help us better understand the drivers of population health so that we may intervene, paving the way for healthier populations. McMichael's paper remains today what it was when it was first published: clear, thoughtful, provocative, and usefully prescriptive in its call to action. McMichael identified 4 constraints facing epidemiology. The field has risen to this challenge and addressed some of these constraints. I discuss how successful (or not) we have been in addressing each of these 4 challenges. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

STS-107 Payload Commander Michael Anderson during TCDT M113 training activities

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- -- STS-107 Payload Commander Michael Anderson takes a break during training on the operation of an M113 armored personnel carrier during Terminal Countdown Demonstration Test activities, a standard part of launch preparations. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia.

Expedition 8 Crew Interviews: C. Michael Foale - CDR

NASA Technical Reports Server (NTRS)

2003-01-01

C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Truss

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Integrated Truss Structure, the primary payload for the mission. The P1 truss will be attached to the central truss segment, S0 Truss, during spacewalks. The payload also includes the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. STS-113 is scheduled to launch Oct. 6, 2002.

A facile and efficient method of enzyme immobilization on silica particles via Michael acceptor film coatings: immobilized catalase in a plug flow reactor.

PubMed

Bayramoglu, Gulay; Arica, M Yakup; Genc, Aysenur; Ozalp, V Cengiz; Ince, Ahmet; Bicak, Niyazi

2016-06-01

A novel method was developed for facile immobilization of enzymes on silica surfaces. Herein, we describe a single-step strategy for generating of reactive double bonds capable of Michael addition on the surfaces of silica particles. This method was based on reactive thin film generation on the surfaces by heating of impregnated self-curable polymer, alpha-morpholine substituted poly(vinyl methyl ketone) p(VMK). The generated double bonds were demonstrated to be an efficient way for rapid incorporation of enzymes via Michael addition. Catalase was used as model enzyme in order to test the effect of immobilization methodology by the reactive film surface through Michael addition reaction. Finally, a plug flow type immobilized enzyme reactor was employed to estimate decomposition rate of hydrogen peroxide. The highly stable enzyme reactor could operate continuously for 120 h at 30 °C with only a loss of about 36 % of its initial activity.

HIGHLY DISATEREOSELECTIVE MICHAEL ADDITION OF FLAVANONE TO ITS CHALCONE PRECURSOR UNDER SOLVENT-FREE CONDITIONS USING MICROWAVES [POSTER

EPA Science Inventory

Substituted 2'-hydroxychalcones were found to give an equilibrium mixture of the starting chalcone and the corresponding flavanone inf 4.6-1:3 ratio in the presence of DBU gave two hitherto unknown diasteromeric dimers in a highly diastereoselective Michael addition of the carban...

Jack Michael's Musings on the 60th Anniversary of Skinner's "Verbal Behavior"

ERIC Educational Resources Information Center

Esch, Barbara E.; Esch, John W.; Palmer, David C.

2017-01-01

When the B. F. Skinner Foundation reprinted Skinner's "Verbal Behavior" in 1992, Jack Michael wrote one of its two forewords, a detailed outline of the book's purpose and scope. On the 60th anniversary of the first publication (1957) of "Verbal Behavior", Jack reflects on the book's impact and its importance to the…

STS-113 Mission Specialist Michael Lopez-Alegria suits up before launch

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria suits up before launch. This will be his third Shuttle flight. The primary mission is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for Nov. 11 at 12:58 a.m. EST.

STS-113 Mission Specialist Michael Lopez-Alegria suits up for launch

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - STS-113 Mission Specialist Michael Lopez-Alegria suits up for launch. He will be making his third Shuttle flight. The primary mission for the crew is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for 8:15 p.m. EST.

Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention.

PubMed

Li, Yan; Zhang, Li-Ping; Dai, Fang; Yan, Wen-Jing; Wang, Hai-Bo; Tu, Zhi-Shan; Zhou, Bo

2015-09-09

Curcumin, derived from the dietary spice turmeric, holds promise for cancer prevention. This prompts much interest in investigating the action mechanisms of curcumin and its analogues. Two symmetrical hexamethoxy-diarylpentadienones (1 and 2) as cucumin analogues were reported to possess significantly enhanced cytotoxicity compared with the parent molecule. However, the detailed mechanisms remain unclear. In this study, compounds 1 and 2 were identified as the G2/M cell cycle arrest agents to mediate the cytotoxicity toward NCI-H460 cells via Michael acceptor-dependent redox intervention. Compared with curcumin, they could more easily induce a burst of reactive oxygen species (ROS) and collapse of the redox buffering system. One possible reason is that they could more effectively target intracellular TrxR to convert this antioxidant enzyme into a ROS promoter. Additionally, they caused up-regulation of p53 and p21 and down-regulation of redox-sensitive Cdc25C along with cyclin B1/Cdk1 in a Michael acceptor- and ROS-dependent fashion. Interestingly, in comparison with compound 2, compound 1 displayed a relatively weak ability to generate ROS but increased cell cycle arrest activity and cytotoxicity probably due to its Michael acceptor-dependent microtubule-destabilizing effect and greater GST-inhibitory activity, as well as its enhanced cellular uptake. This work provides useful information for understanding Michael acceptor-dependent and redox-mediated cytotoxic mechanisms of curcumin and its active analogues.

Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

PubMed Central

Xie, Zong-Bo; Wu, Ming-Yu; He, Ting; Le, Zhang-Gao

2012-01-01

Summary An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions. PMID:22563352

Time, Chance, and Reduction

NASA Astrophysics Data System (ADS)

Ernst, Gerhard; Hüttemann, Andreas

2010-01-01

List of contributors; 1. Introduction Gerhard Ernst and Andreas Hütteman; Part I. The Arrows of Time: 2. Does a low-entropy constraint prevent us from influencing the past? Mathias Frisch; 3. The part hypothesis meets gravity Craig Callender; 4. Quantum gravity and the arrow of time Claus Kiefer; Part II. Probability and Chance: 5. The natural-range conception of probability Jacob Rosenthal; 6. Probability in Boltzmannian statistical mechanics Roman Frigg; 7. Humean mechanics versus a metaphysics of powers Michael Esfeld; Part III. Reduction: 8. The crystallisation of Clausius's phenomenological thermodynamics C. Ulises Moulines; 9. Reduction and renormalization Robert W. Batterman; 10. Irreversibility in stochastic dynamics Jos Uffink; Index.

Gold (III) Chloride-Catalyzed 6-endo-trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones

PubMed Central

Ciesielski, Jennifer; Lebœuf, David; Stern, Harry A.

2013-01-01

Alkynones were treated with boron trifluoride diethyl etherate to generate β-iodoallenolates, which underwent intramolecular aldol reactions to produce cycloalkenyl alcohols. Diastereoselective oxa-Michael ring closure could then be induced by treatment with a catalytic amount of gold(III) chloride, affording highly functionalized tetrahydropyran-containing ring systems. PMID:24032002

Pyrrolidinyl-camphor derivatives as a new class of organocatalyst for direct asymmetric Michael addition of aldehydes and ketones to beta-nitroalkenes.

PubMed

Ting, Ying-Fang; Chang, Chihliang; Reddy, Raju Jannapu; Magar, Dhananjay R; Chen, Kwunmin

2010-06-18

Practical and convenient synthetic routes have been developed for the synthesis of a new class of pyrrolidinyl-camphor derivatives (7 a-h). These novel compounds were screened as catalysts for the direct Michael addition of symmetrical alpha,alpha-disubstituted aldehydes to beta-nitroalkenes. When this asymmetric transformation was catalyzed by organocatalyst 7 f, the desired Michael adducts were obtained in high chemical yields, with high to excellent stereoselectivities (up to 98:2 diastereomeric ratio (d.r.) and 99 % enantiomeric excess (ee)). The scope of the catalytic system was expanded to encompass various aldehydes and ketones as the donor sources. The synthetic application was demonstrated by the synthesis of a tetrasubstituted-cyclohexane derivative from (S)-citronellal, with high stereoselectivity.

STS-113 Crew Interviews: Michael Lopez-Alegria, Mission Specialist 1

NASA Technical Reports Server (NTRS)

2002-01-01

STS-113 Mission Specialist 1 Michael Lopez-Alegria is seen during this preflight interview where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Lopez-Alegria outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the payload (P1 truss) and the crew transfer activities (the crew of Expedition Six is replacing the crew of Expedition Five on the International Space Station (ISS)). Lopez-Alegria discusses the planned EVAs in detail and outlines what supplies will be left for the resident crew. He ends with his thoughts on the importance of the ISS as the second anniversary of human occupation of the Space Station approaches.

Attending to hidden realities: contributions from the work of Michael Polanyi to supervision in pastoral care and counseling.

PubMed

Rodgerson, Thomas E

2008-01-01

In this article, the author suggests that concepts from the work of Michael Polanyi--such as the tacit dimension, subsidiary awareness, and commitment to a yet unrevealed, hidden reality--provide a theoretical basis for understanding the unique formation involved in pastoral care and counseling supervision.

Diagnosis: Michael Moore--media paint filmmaker to be health care system's main problem.

PubMed

Kao, Caroline

2008-01-01

The media reporting on Sicko, Michael Moore's documentary about the failures of the U.S. health care system, provides an example of how corporate media continue to twist and restrict the much-needed debate on health care reform. Aside from an occasional concession that having 46 million uninsured Americans is indeed problematic, the media's hype-filled conversation on health care avoids the issues and echoes old myths about the dangers of "government-run" and "socialized" health care. But in the face of the media demonization, universal health care is remarkably popular among the public.

Official Portrait of Astronaut Michael Collins

NASA Technical Reports Server (NTRS)

1967-01-01

This is the official NASA portrait of astronaut Michael Collins. Collins chose an Air Force career following graduation from West Point. He served as an experimental flight test officer at the Air Force Flight Test Center, Edwards Air Force Base, California, and, in that capacity, tested performance and stability and control characteristics of Air Force aircraft, primarily jet fighters. Having logged approximately 5,000 hours flying time, Collins was one of the third group of astronauts named by NASA in October 1963. Collins completed two space flights, logging 266 hours in space, of which, 1 hour and 27 minutes was spent in Extra Vehicular Activity (EVA). On July 18, 1966, he served as backup pilot for the Gemini VII mission which included a successful rendezvous and docking with a separately launched Agena target vehicle and, using the power of the Agena, maneuvered the Gemini spacecraft into another orbit for a rendezvous with a second, passive Agena. His skillful performance in completing two periods of EVA included the recovery of a micrometeorite detection experiment from the passive Agena. July 16-24, 1969, Collins served as command module (CM) pilot on Apollo 11, the historic first lunar landing mission. He remained aboard the CM, Columbia, on station in lunar orbit and performed the final re-docking maneuvers following a successful lunar orbit rendezvous with the Lunar Module (LM), Eagle. Collins left NASA in January 1970.

Ahead of his time: Jacob Lipman's 1930 estimate of atmospheric sulfur deposition for the conterminous United States

USGS Publications Warehouse

Landa, Edward R.; Shanley, James B.

2015-01-01

A 1936 New Jersey Agricultural Experiment Station Bulletin provided an early quantitative assessment of atmospheric deposition of sulfur for the United States that has been compared in this study with more recent assessments. In the early 20th century, anthropogenic sulfur additions from the atmosphere to the soil by the combustion of fossil fuels were viewed as part of the requisite nutrient supply of crops. Jacob G. Lipman, the founding editor of Soil Science, and his team at Rutgers University, made an inventory of such additions to soils of the conterminous United States during the economic depression of the 1930s as part of a federally funded project looking at nutrient balances in soils. Lipman's team gathered data compiled by the US Bureau of Mines on coal and other fuel consumption by state and calculated the corresponding amounts of sulfur emitted. Their work pioneered a method of assessment that became the norm in the 1970s to 1980s—when acid rain emerged as a national issue. Lipman's estimate of atmospheric sulfur deposition in the 1930 is in reasonable agreement with recent historic reconstructions.

N-heterocyclic carbene-catalyzed tandem aza-benzoin/Michael reactions: on site reversal of the reactivity of N-Boc imines.

PubMed

Wu, Ke-Jia; Li, Gong-Qiang; Li, Yi; Dai, Li-Xin; You, Shu-Li

2011-01-07

A tandem NHC-catalyzed aza-benzoin/Michael reaction has been developed as a method to efficiently produce dihydroindenones and pyrrolidinone-containing tricycles. The novel reaction pattern involves tert-butyl aryl(tosyl)methylcarbamates reacting as both electrophile and nucleophile on the same carbon.

Jack Michael's Appointments at the University of Houston and Arizona State University: Reflections from a Former Student

ERIC Educational Resources Information Center

Mabry, John H.

2016-01-01

Jack Michael was an early enthusiast for what is now called applied behavior analysis. His many seminal contributions were through early publications in applied behavior analysis and the work of the students he trained (e.g., T. Ayllon, M. M. Wolf). His close mentorship of students earned him acclaim as a teacher along with his many theoretical…

Effective Integration of Technology and Instruction. Q&A with Michael Jay. REL Mid-Atlantic Educator Effectiveness Webinar Series

ERIC Educational Resources Information Center

Regional Educational Laboratory Mid-Atlantic, 2015

2015-01-01

In this webinar, long-time educator and developer of education technology Michael Jay discussed the importance of using technology to support learning and gave examples of how teachers can integrate technology into their instruction based on the Common Core State Standards and the Next Generation Science Standards. The PowerPoint presentation and…

Combining silver catalysis and organocatalysis: a sequential Michael addition/hydroalkoxylation one-pot approach to annulated coumarins.

PubMed

Hack, Daniel; Chauhan, Pankaj; Deckers, Kristina; Hermann, Gary N; Mertens, Lucas; Raabe, Gerhard; Enders, Dieter

2014-10-03

A highly stereoselective one-pot procedure for the synthesis of five-membered annulated hydroxycoumarins has been developed. By merging primary amine catalysis with silver catalysis, a series of functionalized coumarin derivatives were obtained in good yields (up to 91%) and good to excellent enantioselectivities (up to 99% ee) via a Michael addition/hydroalkoxylation reaction. Depending on the substituents on the enynone, the synthesis of annulated six-membered rings is also feasible.

Late Quaternary vegetation and climate history of the central Bering land bridge from St. Michael Island, western Alaska

USGS Publications Warehouse

Ager, T.A.

2003-01-01

Pollen analysis of a sediment core from Zagoskin Lake on St. Michael Island, northeast Bering Sea, provides a history of vegetation and climate for the central Bering land bridge and adjacent western Alaska for the past ???30,000 14C yr B.P. During the late middle Wisconsin interstadial (???30,000-26,000 14C yr B.P.) vegetation was dominated by graminoid-herb tundra with willows (Salix) and minor dwarf birch (Betula nana) and Ericales. During the late Wisconsin glacial interval (26,000-15,000 14C yr B.P.) vegetation was graminoid-herb tundra with willows, but with fewer dwarf birch and Ericales, and more herb types associated with dry habitats and disturbed soils. Grasses (Poaceae) dominated during the peak of this glacial interval. Graminoid-herb tundra suggests that central Beringia had a cold, arid climate from ???30,000 to 15,000 14C yr B.P. Between 15,000 and 13,000 14C yr B.P., birch shrub-Ericales-sedge-moss tundra began to spread rapidly across the land bridge and Alaska. This major vegetation change suggests moister, warmer summer climates and deeper winter snows. A brief invasion of Populus (poplar, aspen) occurred ca. 11,000-9500 14C yr B.P., overlapping with the Younger Dryas interval of dry, cooler(?) climate. During the latest Wisconsin to middle Holocene the Bering land bridge was flooded by rising seas. Alder shrubs (Alnus crispa) colonized the St. Michael Island area ca. 8000 14C yr B.P. Boreal forests dominated by spruce (Picea) spread from interior Alaska into the eastern Norton Sound area in middle Holocene time, but have not spread as far west as St. Michael Island. ?? 2003 University of Washington. Published by Elsevier Inc. All rights reserved.

What I Think I May Have Learned--Reflections on 50 Years of Teaching: An Interview with Michael Wertheimer

ERIC Educational Resources Information Center

Michael, Kurt D.

2006-01-01

Kurt Michael is an associate professor in the Department of Psychology at Appalachian State University (ASU) where he teaches history and systems of psychology, abnormal psychology, child psychopathology, and interventions for children and adolescents. He received his BA (cum laude) from the University of Colorado at Boulder and his MS and PhD in…

An improved procedure to prepare 3-methyl-4-nitroalkylenethylisoxazoles and their reaction under catalytic enantioselective Michael addition with nitromethane.

PubMed

Moccia, Maria; Wells, Robert J; Adamo, Mauro F A

2015-02-21

Herein, we describe a short synthesis of 3-methyl-4-nitro-5-alkylethenyl isoxazoles and their reactivity as Michael acceptors. The title compounds reacted with nitromethane under phase-transfer catalysis to provide highly enantioenriched adducts (up to 93% ee) which were then converted to the corresponding γ-nitroacids.

Diastereoselective auxiliary- and catalyst-controlled intramolecular aza-Michael reaction for the elaboration of enantioenriched 3-substituted isoindolinones. Application to the synthesis of a new pazinaclone analogue

PubMed Central

Sallio, Romain; Lebrun, Stéphane; Capet, Frédéric; Agbossou-Niedercorn, Francine

2018-01-01

A new asymmetric organocatalyzed intramolecular aza-Michael reaction by means of both a chiral auxiliary and a catalyst for stereocontrol is reported for the synthesis of optically active isoindolinones. A selected cinchoninium salt was used as phase-transfer catalyst in combination with a chiral nucleophile, a Michael acceptor and a base to provide 3-substituted isoindolinones in good yields and diastereomeric excesses. This methodology was applied to the asymmetric synthesis of a new pazinaclone analogue which is of interest in the field of benzodiazepine-receptor agonists. PMID:29623121

A Philosophy of Jewish Education in Question Marks: A Possible Reading of Michael Rosenak's Last Speech

ERIC Educational Resources Information Center

Rosenak, Avinoam

2014-01-01

Writing this article presents me with an opportunity to look closely at the last speech that my father and mentor, Professor Michael (Mike) Rosenak z"l gave before his passing in 2013. I will write about this speech from a perspective that is based on my intimate familiarity with the questions that concerned him throughout his life. I will…

Michael Francis Madelin (1931--2007): a pioneer in the biology and ecology of conidial fungi and slime moulds.

PubMed

Campbell, Richard

2008-12-01

Michael F Madelin (1931--2007) was Programme Secretary, Vice-President, and President of the British Mycological Society. A summary of his research on Coprinopsis, various conidial fungi, Coelomomyces and myxomycetes is presented, with a full list of his publications. His teaching career was initially at Imperial College, University of London, and then mostly at the University of Bristol.

A Symposium on the Relevance of Michael Polanyi's Insights to a Reformulated Understanding of Science, Technology, and Society

ERIC Educational Resources Information Center

Mead, Walter B.

2011-01-01

This is intended as an introductory statement to the explorations undertaken in the essays that follow. The authors of these essays attempt to introduce the reader to some of the insights of Michael Polanyi and their implications for the reader who wishes to come to a greater understanding of modern technological society, which--for better or…

[Early career of Michael Sendivogius].

PubMed

Prinke, Rafał T

2012-01-01

One of the most influential alchemical authors of the early modern period was Michael Sendivogius whose early life is shrouded in mystery. He may be labelled the most famous Polish scientific writer between Copernicus and Marie Skłodowska-Curie, but because of the difficulties involved in researching the biography of any alchemist, there has been relatively little interest in him among Polish historians. The early work of Roman Bugaj (author of the still fundamental monograph) and Włodzimierz Hubicki (who made his research available to the international community) has been continued only by the English-born Zbigniew Szydło and the author of this article. The roots of many legends about Sendivogius were three mid-17th century short biographies, none of which is trustworthy, so it is crucial to verify the received myth and the version constructed in the 1960's and 1970's with primary sources and evidence from the recent "new historiography of alchemy". The present article examines them in the light of newly discovered sources and reinterpretation of the old ones. The genealogy of the Sedzimir family is discussed at length to show that Sendivogius most probably was not its member but only a pretender in order to assume (or prove) the status of a nobleman. Several possible hypotheses about his origins are presented. He is known to have studied at three universities (Leipzig, Vienna and Altdorf) but authors of early panegyrics dedicated to Sendivogius list more universities which he may have attended. The most interesting is that of Cambridge, listed as the first one, because practically no Poles or Czechs went there at the time. Finally, his marriage to Veronica Stiebar, a wealthy widow of a Franconian knightly family, and her interesting family relationships (links to Erasmus, Camerarius, Paracelsus and the original Doctor Faustus) are discussed. The period covered is that before Sendivogius moved to Prague in about 1597, having already been a courtier of Rudolf II

Michael Hauskeller: Sex and the Posthuman Condition : Palgrave-Macmillan, 2014, 98 pp.

PubMed

Miller, Lantz Fleming

2016-10-01

This new book from Michael Hauskeller explores the currently marketed or projected sex/love products that exhibit some trait of so-called "posthumanistic" theory or design. These products are so designated because of their intention to fuse high technologies, including robotics and computing, with the human user. The author offers several arguments for why the theory behind these products leads to inconsistencies. The book uses a unique approach to philosophical argument by enmeshing the argument's major points in a concomitant discussion of pieces from world literature pertaining to posthumanism. The method is compelling, heightened by great world authorial insights that rarely find their way into philosophy and shores up some strong argumentative points. Yet some of the argument still needs more elucidating.

Efficient synthesis of optically active 4-nitro-cyclohexanones via bifunctional thiourea-base catalyzed double-Michael addition of nitromethane to dienones.

PubMed

Wu, Bin; Liu, Guo-Gui; Li, Mei-Qiu; Zhang, Yong; Zhang, Shao-Yun; Qiu, Jun-Ru; Xu, Xiao-Ping; Ji, Shun-Jun; Wang, Xing-Wang

2011-04-07

Thiourea-modified cinchona alkaloids as bifunctional catalysts and a base could catalyze a stepwise [5+1] cyclization of divinyl ketones with nitromethane via double Michael additions, furnishing optically active 4-nitro-cyclohexanones with good yields, excellent diastereoselectivities (>20 : 1) and high enantiomeric ratios (up to 97 : 3).

Michael Addition Polymerization of Trifunctional Amine and Acrylic Monomer: A Versatile Platform for Development of Biomaterials.

PubMed

Cheng, Weiren; Wu, Decheng; Liu, Ye

2016-10-10

Michael addition polymerizations of amines and acrylic monomers are versatile approaches to biomaterials for various applications. A combinatorial library of poly(β-amino ester)s and diverse poly(amido amine)s from diamines and diacrylates or bis(acrylamide)s have been reported, respectively. Furthermore, novel linear and hyperbranched polymers from Michael addition polymerizations of trifunctional amines and acrylic monomers significantly enrich this category of biomaterials. In this Review, we focus on the biomaterials from Michael addition polymerizations of trifunctional amines and acrylic monomers. First we discuss how the polymerization mechanisms, which are determined by the reactivity sequence of the three types of amines of trifunctional amines, i.e., secondary (2°) amines (original), primary (1°) amines, and 2° amines (formed), are affected by the chemistry of monomers, reaction temperature, and solvent. Then we update how to design and synthesize linear and hyperbranched polymers based on the understanding of polymerization mechanisms. Linear polymers containing 2° amines in the backbones can be obtained from polymerizations of diacrylates or bis(acrylamide)s with equimolar trifunctional amine, and several approaches, e.g., 2A 2 +BB'B″, A 3 +2BB'B', A 2 +BB'B″, to hyperbranched polymers are developed. Further through molecular design of monomers, conjugation of functional species to 2° amines in the backbones of linear polymers and the abundant terminal groups of hyperbranched polymers, the amphiphilicity of polymers can be adjusted, and additional stimuli, e.g., thermal, redox, reactive oxidation species (ROS), and light, responses can be integrated with the intrinsic pH response. Finally we discuss the applications of the polymers for gene/drug delivery and bioimaging through exploring their self-assemblies in various motifs, e.g., micelles, polyplexes particles/nanorings and hydrogels. Redox-responsive hyperbranched polymers can display 300

Race, punishment, and the Michael Vick experience.

PubMed

Piquero, Alex R; Piquero, Nicole Leeper; Gertz, Marc; Baker, Thomas; Batton, Jason; Barnes, J C

2011-01-01

Objective. The relationship between race and crime has been contentious, focusing primarily on offending and incarceration patterns among minorities. There has been some limited work on public perceptions of criminal punishment, and findings show that while minorities believe in the role and rule of law, they simultaneously perceive the justice system as acting in a biased and/or unfair manner. Two limitations have stalled this literature. First, research has focused mainly on criminal punishments to the neglect of noncriminal punishments. Second, most studies have not examined whether race remains salient after considering other demographic variables or discrimination and legitimacy attitudes.Methods. Using data from 400 adults, we examine how race affects perceptions of criminal punishment and subsequent reinstatement into the National Football League in the case of Michael Vick, a star professional quarterback who pled guilty to charges of operating an illegal dog-fighting ring.Results. Findings show that whites are more likely to view Vick's punishment as too soft and that he should not be reinstated, while nonwhites had the opposite views. Race remained significant after controlling for other variables believed to be related to punishment perceptions.Conclusion. Attitudes toward both criminal punishment and NFL reinstatement vary across race such that there exists important divides in how individuals perceive the system meting out punishment and subsequently reintegrating offenders back into society. These results underscore that white and nonwhites perceive the law and its administration differently.

The publication strategies of Jöns Jacob Berzelius (1779-1848): negotiating national and linguistic boundaries in chemistry.

PubMed

Beckman, Jenny

2016-04-01

This article follows the publication strategies of the Swedish chemist Jöns Jacob Berzelius (1779-1848). It focuses on the role of language and translation in Berzelius' efforts to strengthen his own reputation, and that of Swedish science. As an author and editor, Berzelius encouraged the translation of his own works into several languages, while endeavouring to preserve the status of Swedish as a language of scientific publication in the face of French, and increasingly German and English, dominance. Reforming the Transactions of the Royal Swedish Academy of Sciences and launching several new scientific periodicals, Berzelius also attempted to influence the publication practices in other countries. Recent scholarship on the history of scientific publication has drawn attention to the practical difficulties of determining and getting hold of the relevant publications in one's field, the 'malleability' of the journal medium, and the common practice of reprinting and summarising papers published elsewhere. Berzelius' publication strategies highlight translation - time-consuming, unreliable and problematic in terms of authorisation and ownership - as one aspect of the wider problem of communicating across national and linguistic boundaries. Berzelius' struggles with the practicalities of communicating across borders in times of war, the choice of language and its consequences, and national standards of publication, demonstrate the importance of a transnational perspective on the history of scientific publication.

Michael Novak's "Business as a Calling" as a Vehicle for Addressing Ethical and Policy Concerns in a Business Law Course

ERIC Educational Resources Information Center

Murphy, Tonia Hap

2008-01-01

This article describes the author's experience of incorporating Michael Novak's "Business as a Calling: Work and the Examined Life" into a Business Law course. The author views it as a positive addition to the course, one that may be of interest to her colleagues at other institutions. Accordingly, after an overview of Novak's analysis in…

Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives

PubMed Central

Al-Majid, Abdullah M.; Barakat, Assem; AL-Najjar, Hany J.; Mabkhot, Yahia N.; Ghabbour, Hazem A.; Fun, Hoong-Kun

2013-01-01

A simple protocol, involving the green synthesis for the construction of novel bis-pyrimidine derivatives, 3a–i and 4a–e are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%–99%). PMID:24317435

Michael E. Lamb: Award for Distinguished Senior Career Contributions to Psychology in the Public Interest.

PubMed

2015-11-01

The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2015 co-recipient of the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest is Michael E. Lamb. Lamb was selected because his "work profoundly shaped the fields of developmental psychology, social welfare, child and family policy, and law." Lamb's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

A colorimetric detection of acrylamide in potato chips based on nucleophile-initiated thiol-ene Michael addition.

PubMed

Hu, Qinqin; Fu, Yingchun; Xu, Xiahong; Qiao, Zhaohui; Wang, Ronghui; Zhang, Ying; Li, Yanbin

2016-02-07

Acrylamide (AA), a neurotoxin and a potential carcinogen, has been found in various thermally processed foods such as potato chips, biscuits, and coffee. Simple, cost-effective, and sensitive methods for the rapid detection of AA are needed to ensure food safety. Herein, a novel colorimetric method was proposed for the visual detection of AA based on a nucleophile-initiated thiol-ene Michael addition reaction. Gold nanoparticles (AuNPs) were aggregated by glutathione (GSH) because of a ligand-replacement, accompanied by a color change from red to purple. In the presence of AA, after the thiol-ene Michael addition reaction between GSH and AA with the catalysis of a nucleophile, the sulfhydryl group of GSH was consumed by AA, which hindered the subsequent ligand-replacement and the aggregation of AuNPs. Therefore, the concentration of AA could be determined by the visible color change caused by dispersion/aggregation of AuNPs. This new method showed high sensitivity with a linear range from 0.1 μmol L(-1) to 80 μmol L(-1) and a detection limit of 28.6 nmol L(-1), and especially revealed better selectivity than the fluorescence sensing method reported previously. Moreover, this new method was used to detect AA in potato chips with a satisfactory result in comparison with the standard methods based on chromatography, which indicated that the colorimetric method can be expanded for the rapid detection of AA in thermally processed foods.

STS-92 M.S. Michael Lopez-Alegria suits up for launch

NASA Technical Reports Server (NTRS)

2000-01-01

During suitup in the Operations and Checkout Building, STS-92 Mission Specialist Michael E. Lopez-Alegria smiles and clasps his hands in anticipation of a second launch attempt. He and the rest of the crew will be heading out to the Astrovan for the ride to Launch Pad 39A. During the 11-day mission to the International Space Station, four extravehicular activities (EVAs), or spacewalks, are planned for construction. The payload includes the Integrated Truss Structure Z-1 and the third Pressurized Mating Adapter. The Z-1 truss is the first of 10 that will become the backbone of the Space Station, eventually stretching the length of a football field. PMA-3 will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. Launch is scheduled for 7:17 p.m. EDT. Landing is expected Oct. 22 at 2:10 p.m. EDT.

Michael Faraday on the Learning of Science and Attitudes of Mind

NASA Astrophysics Data System (ADS)

Crawford, Elspeth

The paper makes use of Michael Faraday's ideas about learning, in particular his thoughts about attitudes to the unknowns of science and the development of an attitude which improves scientific decision-making. An invented scenario involving nursery school children demonstrates some attitudes displayed there. Discussion of the scenario and variation in possible outcomes suggests that Faraday's views are relevant to scientific learning in general. The main thesis of the paper is that it is central to learning in science to acknowledge that there is an inner struggle involved in facing unknowns, and that empathy with the fears and expectations of learners is an essential quality if genuinely scientific thought is to develop. It is suggested, following Faraday, that understanding our own feelings while we teach is a pre-requisite to enabling such empathy and that only then will we be in a position to evaluate accurately whether or not our pupils are thinking scientifically.

New Light on the Alchemical Writings of Michael Sendivogius (1566-1636).

PubMed

Prinke, Rafał T

2016-08-01

The Polish alchemist Michael Sendivogius is best known for the influential Novum lumen chymicum, a work composed of three separate texts. Sendivogius's authorship was questioned in the mid-seventeenth century, and these reservations are still held by some modern historians. On the other hand, other early modern and modern readers not only accepted his authorship of all three texts, but also ascribed as many as eleven texts to him. This paper discusses the key works published under the anagrammatised name of Sendivogius with the aim of resolving the authorship question. Newly discovered evidence makes it possible to trace the circumstances leading to the publication of these works in much greater detail than previously, and to present new arguments affirming Sendivogius's authorship. In the Tractatus de sulphure, Sendivogius promised to write another two treatises, which readers sought to identify and (in some cases) to write themselves. This paper sets out, and rejects, the arguments for including them in the corpus of genuine Sendivogian writings.

Lizards, ticks and contributions to Australian parasitology: C. Michael Bull (1947-2016).

PubMed

Godfrey, Stephanie S; Gardner, Michael G

2017-12-01

Professor C. Michael Bull was a great scientist and mentor, and an Associate Editor of this journal. While his research career spanned the fields of behavioural ecology, conservation biology and herpetology, in this article, we pay tribute to his major contribution to Australian parasitology. Mike authored more than eighty articles on host-parasite ecology, and revealed major insights into the biology and ecology of ticks from his long term study of the parapatric boundary of two tick species ( Amblyomma limbatum and Bothriocroton hydrosauri ) on the sleepy lizard ( Tiliqua rugosa ). In this article, we provide an overview of how this research journey developed to become one of the longest-running studies of lizards and their ticks, totalling 35 years of continuous surveys of ticks on lizards, and the insights and knowledge that he generated along that journey.

Radiation therapy in the treatment of cervical cancer: The University of Chicago/Michael Reese Hospital experience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rader, J.S.; Haraf, D.J.; Halpern, H.J.

1990-07-01

A retrospective analysis was conducted on 307 patients referred for radiation therapy at The University of Chicago and Michael Reese Hospital between 1971 and 1986. Median follow-up was 6.4 years. Treatment techniques varied during the time of the study. Actuarial disease-free survivals were 78%, 64%, 55%, 33%, 41%, and 60% for stage IB, IIA, IIB, IIIA, IIIB, and IVA, respectively. Stage, size of the cervical lesion, and hemoglobin level during treatment were prognostic factors. Treatment technique as well as time dose factors were analyzed with respect to survival, failures, and complications.

Enantioselective total synthesis of (-)-strychnine using the catalytic asymmetric Michael reaction and tandem cyclization.

PubMed

Ohshima, Takashi; Xu, Youjun; Takita, Ryo; Shimizu, Satoshi; Zhong, Dafang; Shibasaki, Masakatsu

2002-12-11

The enantioselective total synthesis of (-)-strychnine was accomplished through the use of the highly practical catalytic asymmetric Michael reaction (0.1 mol % of (R)-ALB, more than kilogram scale, without chromatography, 91% yield and >99% ee) as well as a tandem cyclization that simultaneously constructed B- and D-rings (>77% yield). Moreover, newly developed reaction conditions for thionium ion cyclization, NaBH3CN reduction of the imine moiety in the presence of Lewis acid to prevent ring opening reaction, and chemoselective reduction of the thioether (desulfurization) in the presence of exocyclic olefin were pivotal to complete the synthesis. The described chemistry paves the way for the synthesis of more advanced Strychnos alkaloids.

A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates.

PubMed

Garrabou, Xavier; Beck, Tobias; Hilvert, Donald

2015-05-04

Recent advances in computational design have enabled the development of primitive enzymes for a range of mechanistically distinct reactions. Here we show that the rudimentary active sites of these catalysts can give rise to useful chemical promiscuity. Specifically, RA95.5-8, designed and evolved as a retro-aldolase, also promotes asymmetric Michael additions of carbanions to unsaturated ketones with high rates and selectivities. The reactions proceed by amine catalysis, as indicated by mutagenesis and X-ray data. The inherent flexibility and tunability of this catalyst should make it a versatile platform for further optimization and/or mechanistic diversification by directed evolution. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

'Introducing Michael Gove to Loïc Wacquant': Why Social Work Needs Critical Sociology.

PubMed

Michael Garrett, Paul

2016-06-01

In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the 'agency' of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015.

A rapid, one-pot, microwave-influenced synthesis of spiro-2,5-diketopiperazines via a cascade Ugi/6-exo-trig aza-Michael reaction.

PubMed

Santra, Soumava; Andreana, Peter R

2011-04-01

A rapid, cascade reaction process has been developed to access biologically validated spiro-2,5-diketopiperazines. The facile and environmentally benign method capitalizes on commercially available starting reagents for a sequential Ugi/6-exo-trig aza-Michael reaction, water as a solvent, and microwave irradiation without any extraneous additives.

Mechanistic Kinetic Modeling of Thiol-Michael Addition Photopolymerizations via Photocaged "Superbase" Generators: An Analytical Approach.

PubMed

Claudino, Mauro; Zhang, Xinpeng; Alim, Marvin D; Podgórski, Maciej; Bowman, Christopher N

2016-11-08

A kinetic mechanism and the accompanying mathematical framework are presented for base-mediated thiol-Michael photopolymerization kinetics involving a photobase generator. Here, model kinetic predictions demonstrate excellent agreement with a representative experimental system composed of 2-(2-nitrophenyl)propyloxycarbonyl-1,1,3,3-tetramethylguanidine (NPPOC-TMG) as a photobase generator that is used to initiate thiol-vinyl sulfone Michael addition reactions and polymerizations. Modeling equations derived from a basic mechanistic scheme indicate overall polymerization rates that follow a pseudo-first-order kinetic process in the base and coreactant concentrations, controlled by the ratio of the propagation to chain-transfer kinetic parameters ( k p / k CT ) which is dictated by the rate-limiting step and controls the time necessary to reach gelation. Gelation occurs earlier as the k p / k CT ratio reaches a critical value, wherefrom gel times become nearly independent of k p / k CT . The theoretical approach allowed determining the effect of induction time on the reaction kinetics due to initial acid-base neutralization for the photogenerated base caused by the presence of protic contaminants. Such inhibition kinetics may be challenging for reaction systems that require high curing rates but are relevant for chemical systems that need to remain kinetically dormant until activated although at the ultimate cost of lower polymerization rates. The pure step-growth character of this living polymerization and the exhibited kinetics provide unique potential for extended dark-cure reactions and uniform material properties. The general kinetic model is applicable to photobase initiators where photolysis follows a unimolecular cleavage process releasing a strong base catalyst without cogeneration of intermediate radical species.

Using Our Voices, Losing Our Bodies: Michael Brown, Trayvon Martin, and the Spirit Murders of Black Male Professors in the Academy

ERIC Educational Resources Information Center

Johnson, Lamar; Bryan, Nathaniel

2017-01-01

The recent deaths of Michael Brown, Trayvon Martin, and other Black males have generated new civil rights urgencies in Black communities and spirited academic discourses in higher education regarding the educational and social plight of Black males in America. Connecting the deaths of Black males to our lived experiences in the academy, we use a…

What's in a Name? That Which We Call a Crisis? A Commentary on Michael Young's Article "Overcoming the Crisis in Curriculum Theory"

ERIC Educational Resources Information Center

Lundgren, Ulf P.

2015-01-01

Michael Young's article "Overcoming the crisis in curriculum theory: a knowledge-based approach" ("JCS, 45", 2) is discussed from the starting point that the claimed crisis is constructed from a decisive solution, that is the solution determines what is a crisis. But curriculum research and curriculum theory are in need of…

Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography.

PubMed

Lin, Hui; Ou, Junjie; Liu, Zhongshan; Wang, Hongwei; Dong, Jing; Zou, Hanfa

2015-01-30

A facile approach based on thiol-methacrylate Michael addition click reaction was developed for construction of porous hybrid monolithic materials. Three hybrid monoliths were prepared via thiol-methacrylate click polymerization by using methacrylate-polyhedral oligomeric silsesquioxane (POSS) (cage mixture, n=8, 10, 12, POSS-MA) and three multi-thiol crosslinkers, 1,6-hexanedithiol (HDT), trimethylolpropane tris(3-mercaptopropionate) (TPTM) and pentaerythritol tetrakis(3-mercaptopropionate) (PTM), respectively, in the presence of porogenic solvents (n-propanol and PEG 200) and a catalyst (dimethylphenylphosphine, DMPP). The obtained monoliths possessed high thermal and chemical stabilities. Besides, they all exhibited high column efficiencies and excellent separation abilities in capillary liquid chromatography (cLC). The highest column efficiency could reach ca. 195,000N/m for butylbenzene on the monolith prepared with POSS-MA and TPTM (monolith POSS-TPTM) in reversed-phase (RP) mode at 0.64mm/s. Good chromatographic performance were all achieved in the separations of polycyclic aromatic hydrocarbons (PAHs), phenols, anilines, EPA 610 as well as bovine serum albumin (BSA) digest. The high column efficiencies in the range of 51,400-117,000N/m (achieved on the monolith POSS-PTM in RP mode) convincingly demonstrated the high separation abilities of these thiol-methacrylate based hybrid monoliths. All the results demonstrated the feasibility of the phosphines catalyzed thiol-methacrylate Michael addition click reaction in fabrication of monolithic columns with high efficiency for cLC applications. Copyright © 2014 Elsevier B.V. All rights reserved.

Facile Iodine-Catalyzed Michael Addition of Indoles to α,α′-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones

PubMed Central

Pal, Rammohan; Das Gupta, Arpita; Mallik, Asok K.

2012-01-01

Iodine-catalyzed reaction of indoles with α,α′-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. The products form a new group of indole derivatives. PMID:24052849

Michael Fordham and the Journal of Analytical Psychology: the view from Hangman's Hill.

PubMed

Urban, Elizabeth

2015-09-01

This short paper was presented to a conference in honour of the 60(th) year of the JAP and was one of others that acknowledged the contribution of Michael Fordham. The subtitle refers to the paper's overview of Fordham's published oeuvre and the particular place of the Journal of Analytical Psychology, for which he was the founding editor. Fordham's contribution to a Jungian-based model of development is discussed, with reference to his papers in the British Journal of Medical Psychology. The paper notes miscellaneous pieces from Fordham's commentaries, obituaries, papers and reviews which capture not only the development of Fordham as a thinker but also his character. There is discussion of his reviews of Melanie Klein's Envy and Gratitude and manuscripts by Erich Neumann. A reminiscence of Fordham as supervisor is recounted. © 2015, The Society of Analytical Psychology.

Forty Years of "Pastoral Care": An Appraisal of Michael Marland's Seminal Book and Its Significance for Pastoral Care in Schools

ERIC Educational Resources Information Center

Best, Ron

2014-01-01

Michael Marland's seminal book: "Pastoral Care" was published 40 years ago this year. The thesis of the book--that pastoral care is the central task of the school, and must be planned and institutionalized through pastoral roles and structures--is explored against the background of the social, cultural and educational developments…

The Impact of Socio-Cultural Differences on Educational Values: A Comparison of the Pedagogy of Michael Oakeshott and John McGahern

ERIC Educational Resources Information Center

Williams, Kevin

2017-01-01

The year 2016 marked the tenth anniversary of the death of John McGahern (born 1934), the widely acclaimed Irish author. There is a shared temper of mind and several common strands in the work of McGahern and that of the English philosopher, Michael Oakeshott (1900-1990). Despite the very different cultural environments in which they grew up and…

‘Introducing Michael Gove to Loïc Wacquant’: Why Social Work Needs Critical Sociology

PubMed Central

Michael Garrett, Paul

2016-01-01

In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the ‘agency’ of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015. PMID:27559203

Heterobimetallic Pd-Sn catalysis: Michael addition reaction with C-, N-, O-, and S-nucleophiles and in situ diagnostics.

PubMed

Das, Debjit; Pratihar, Sanjay; Roy, Sujit

2013-03-15

An efficient Michael addition reaction of differently substituted enones with carbon, sulfur, oxygen, and nitrogen nucleophiles has been achieved by a new heterobimetallic "Pd-Sn" catalyst system. The nature of the catalytically relevant species and their interactions with the enone moiety has been examined by spectroscopy. The effect of ligand and the coordination mode of enone with "Pd-Sn" heterobimetallic system have been investigated by kinetics and DFT studies. A straightforward application of this methodology is shown in the synthesis of 1,4-oxathiepane core.

Organocatalytic Enantioselective Michael/Cyclization Domino Reaction between 3-Amideoxindoles and α,β-Unsaturated Aldehydes: One-Pot Preparation of Chiral Spirocyclic Oxindole-γ-lactams.

PubMed

Yang, Peng; Wang, Xiao; Chen, Feng; Zhang, Zheng-Bing; Chen, Chao; Peng, Lin; Wang, Li-Xin

2017-04-07

The first organocatalytic enantioselective Michael/cyclization domino reaction between 3-amideoxindoles and α,β-unsaturated aldehydes is described. After sequential oxidation with pyridinium chlorochromate, a direct and one-pot preparation of highly sterically hindered spirocyclic oxindole-γ-lactams was achieved in 51-81% yields with 75-97% ee and ≤80/20 dr.

Review Article: Yamada, Jeni "Laura: A Case for the Modularity of Language"; Tomasello, Michael "First Verbs: A Case Study of Early Grammatical Development."

ERIC Educational Resources Information Center

Shatz, Marilyn

1994-01-01

Jeni Yamada's "Laura" and Michael Tomasello's "First Verbs" continue a tradition of providing useful information on the language ability of individuals in a depth rarely found in multisubject studies; however, these efforts are unusual for case studies in that both take strong theoretical positions on the essence of language and language learning.…

"Integration was a Solution to Segregation, but Integration does not Address Quality Education": A Conversation about School Desegregation with Dr. Michael A. Middleton

ERIC Educational Resources Information Center

Diem, Sarah; Brooks, Jeffrey

2013-01-01

We conclude this special issue reflecting back on the history of desegregation and questioning how we move forward in trying to achieve racially integrated school settings. The epilogue includes a conversation with Dr. Michael A. Middleton, Deputy Chancellor of the University of Missouri-Columbia. Dr. Middleton is an expert in civil rights and…

Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

PubMed

Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R

2012-08-13

The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.

Automated Synthesis of a Library of Triazolated 1,2,5-Thiadiazepane 1,1-Dioxides via a Double aza-Michael Strategy

PubMed Central

Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H.; Santini, Conrad; Organ, Michael G.; Hanson, Paul R.

2013-01-01

The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3+2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products. PMID:22853708

Diversity-oriented asymmetric catalysis (DOAC): stereochemically divergent synthesis of thiochromanes using an imidazoline-aminophenol-nickel-catalyzed Michael/Henry reaction.

PubMed

Arai, Takayoshi; Yamamoto, Yushi

2014-03-21

The (S,S)-diphenylethylenediamine-derived imidazoline-aminophenol-Ni complex catalyzed tandem asymmetric Michael/Henry reaction of 2-mercaptobenzaldehydes with β-nitrostyrenes to give the corresponding (2S,3R,4R)-2-aryl-3-nitrothiochroman-4-ols in up to 99% diastereoselectivity with 95% ee was demonstrated in diversity-oriented asymmetric catalysis. Reduction of the nitro group of the chiral thiochromanes gave a new series of (2S,3R,4R)-3-amino-2-arylthiochroman-4-ols with retention of the strereoselectivity.

Enantioselective organocatalytic one-pot amination/aza-Michael/aldol condensation reaction sequence: synthesis of 3-pyrrolines with a quaternary stereocenter.

PubMed

Desmarchelier, Alaric; Coeffard, Vincent; Moreau, Xavier; Greck, Christine

2012-10-08

Primary amine-catalyzed direct conversion of α,α-disubstituted aldehydes into 3-pyrrolines with a quaternary stereocenter is reported. The one-pot enantioselective sequence is based on a α-amination, an aza-Michael addition of hydrazine, an aldol condensation dehydratation and proceeds with good yields and excellent levels of enantioselectivity. Synthetically attractive applications including the formation of aziridinopyrrolidine or epoxypyrrolidine derivatives with good yields and selectivities are also described. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Smart and intelligent sensor payload project

NASA Image and Video Library

2009-04-01

Engineers working on the smart and intelligent sensor payload project include (l to r): Ed Conley (NASA), Mark Mitchell (Jacobs Technology), Luke Richards (NASA), Robert Drackett (Jacobs Technology), Mark Turowski (Jacobs Technology) , Richard Franzl (seated, Jacobs Technology), Greg McVay (Jacobs Technology), Brianne Guillot (Jacobs Technology), Jon Morris (Jacobs Technology), Stephen Rawls (NASA), John Schmalzel (NASA) and Andrew Bracey (NASA).

Taking Care of You: Self-Care for Family Caregivers

MedlinePlus

... in the following words modified from the original Serenity Prayer (attributed to American theologian Reinhold Niebuhr): “ God grant me the serenity to accept the things I cannot change, Courage ...

Michael Young, the Institute of Community Studies, and the Politics of Kinship.

PubMed

Butler, Lise

2015-01-01

This article examines the East London-based Institute of Community Studies, and its founder, Michael Young, to show that sociology and social research offered avenues for left-wing political expression in the 1950s. Young, who had previously been Head of the Labour Party Research Department during the Attlee government, drew upon existing currents of psychological and sociological research to emphasize the continuing relevance of the extended family in industrial society and to offer a model of socialist citizenship, solidarity and mutual support not tied to productive work. Young and his colleagues at the Institute of Community Studies promoted the supportive kinship networks of the urban working class, and an idealized conception of the relationships between women, to suggest that family had been overlooked by the left and should be reclaimed as a progressive force. The article shows that the Institute's sociological work was informed by a pre-existing concern with family as a model for cooperative socialism, and suggests that sociology and social research should be seen as important sources of political commentary for scholars of post-war politics.

Jacob's Ladder as Sketched by Escher: Assessing the Performance of Broadly Used Density Functionals on Transition Metal Surface Properties.

PubMed

Vega, Lorena; Ruvireta, Judit; Viñes, Francesc; Illas, Francesc

2018-01-09

The present work surveys the performance of various widely used density functional theory exchange-correlation (xc) functionals in describing observable surface properties of a total of 27 transition metals with face-centered cubic (fcc), body-centered cubic (bcc), or hexagonal close-packed (hcp) crystallographic structures. A total of 81 low Miller index surfaces were considered employing slab models. Exemplary xc functionals within the three first rungs of Jacob's ladder were considered, including the Vosko-Wilk-Nusair xc functional within the local density approximation, the Perdew-Burke-Ernzerhof (PBE) functional within the generalized gradient approximation (GGA), and the Tao-Perdew-Staroverov-Scuseria functional as a meta-GGA functional. Hybrids were excluded in the survey because they are known to fail in properly describing metallic systems. In addition, two variants of PBE were considered, PBE adapted for solids (PBEsol) and revised PBE (RPBE), aimed at improving adsorption energies. Interlayer atomic distances, surface energies, and surface work functions were chosen as the scrutinized properties. A comparison with available experimental data, including single-crystal and polycrystalline values, shows that no xc functional is best at describing all of the surface properties. However, in statistical mean terms the PBEsol xc functional is advised, while PBE is recommended when considering both bulk and surface properties. On the basis of the present results, a discussion of adapting GGA functionals to the treatment of metallic surfaces in an alternative way to meta-GGA or hybrids is provided.

Basic-functionalized recyclable ionic liquid catalyst: A solvent-free approach for Michael addition of 1,3-dicarbonyl compounds to nitroalkenes under ultrasound irradiation.

PubMed

Narayanaperumal, Senthil; da Silva, Rodrigo César; Feu, Karla Santos; de la Torre, Alexander Fernández; Corrêa, Arlene G; Paixão, Márcio Weber

2013-05-01

A task-specific ionic liquid (TSIL) has been introduced as a recyclable catalyst in Michael addition. A series of nitroalkenes and various C-based nucleophiles were reacted in the presence of 30mol% of recyclable basic-functionalized ionic liquid. Good to excellent yields were obtained in 30min under ultrasound irradiation. Copyright © 2012 Elsevier B.V. All rights reserved.

Jacob K. Javits Gifted and Talented Children and Youth Education Act, and Office of Comprehensive School Health Education Act of 1987. Hearing on S. 303 and S. 1348 before the Subcommittee on Education, Arts and Humanities of the Committee on Labor and Human Resources. United State Senate, One Hundredth Congress, First Session (September 18, 1987).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Subcommittee on Education, Arts and Humanities.

The document contains testimony presented in a 1987 Senate committee hearing on two education bills. The first bill, entitled the Jacob K. Javits Gifted and Talented Children and Youth Education Act, is designed to establish a discretionary grant program within the Department of Education to provide funds to local education agencies for programs…

How "The Right" Continues to "Do Wrong" by Our Young People: Contemporary Reflections on Michael Apple's Analysis of the "Rightist Turn" in Education

ERIC Educational Resources Information Center

McGregor, Glenda

2018-01-01

Michael Apple's 2005 article, "Doing Things the 'Right' Way: Legitimating Educational Inequalities in Conservative Times", is a seminal piece of writing that highlights some of his core concerns with the effects of neo-liberal and neo-conservative ideologies on education. Since its publication, this article has incited much debate about…

β-Amino acid catalyzed asymmetric Michael additions: design of organocatalysts with catalytic acid/base dyad inspired by serine proteases.

PubMed

Yang, Hui; Wong, Ming Wah

2011-09-16

A new type of chiral β-amino acid catalyst has been computationally designed, mimicking the enzyme catalysis of serine proteases. Our catalyst approach is based on the bioinspired catalytic acid/base dyad, namely, a carboxyl and imidazole pair. DFT calculations predict that this designed organocatalyst catalyzes Michael additions of aldehydes to nitroalkenes with excellent enantioselectivities and remarkably high anti diastereoselectivities. The unusual stacked geometry of the enamine intermediate, hydrogen bonding network, and the adoption of an exo transition state are the keys to understand the stereoselectivity. © 2011 American Chemical Society

Partnering with NASA JSC for Community Research Needs; Collaborative and Student Opportunities via Jacobs and Psams Initiative

NASA Astrophysics Data System (ADS)

Danielson, L. R.; Draper, D. S.

2016-12-01

NASA Johnson Space Center's (JSC) Astromaterials Research and Exploration Science Division houses a unique combination of laboratories and other assets for conducting cutting-edge planetary research. These facilities have been accessed for decades by outside scientists; over the past five years, the 16 full time contract research and technical staff members in our division have hosted a total of 223 visiting researchers, representing 35 institutions. We intend to submit a proposal to NASA specifically for facilities support and establishment of our laboratories as a collective, PSAMS, Planetary Sample Analyses and Mission Science, which should result in substantial cost savings to PIs who wish to use our facilities. JSC is a recognized NASA center of excellence for curation, and in future will allow PIs easy access to samples in Curation facilities that they have been approved to study. Our curation expertise could also be used for a collection of experimental run products and standards that could be shared and distributed to community members, products that could range from 1 bar controlled atmosphere furnace, piston cylinder, multi-anvil, to shocked products. Coordinated analyses of samples is one of the major strengths of our division, where a single sample can be prepared with minimal destruction for a variety of chemical and structural analyses, from macro to nano-scale. A CT scanner will be delivered August 2016 and installed in the same building as all the other division experimental and analytical facilities, allowing users to construct a 3 dimensional model of their run product and/or starting material before any destruction of their sample for follow up analyses. The 3D printer may also be utilized to construct containers for diamond anvil cell experiments. Our staff scientists will work with PIs to maximize science return and serve the needs of the community. We welcome student visitors, and a graduate semester internship is available through Jacobs.

Organocatalytic asymmetric anti-selective Michael reactions of aldehydes and the sequential reduction/lactonization/Pauson-Khand reaction for the enantioselective synthesis of highly functionalized hydropentalenes.

PubMed

Hong, Bor-Cherng; Dange, Nitin S; Yen, Po-Jen; Lee, Gene-Hsiang; Liao, Ju-Hsiou

2012-10-19

A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% ee). This process combines an enantioselective organocatalytic anti-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson-Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis.

Mandibular angle augmentation with the use of distraction and homologous lyophilized cartilage in a case of morphing to Michael Jackson surgery.

PubMed

Mommaerts, M Y; Abeloos, J S; Gropp, H

2001-08-01

Correction of an ill-defined mandibular angle is not an easy task, whether it is requested by the "congenital, orthognathic or cosmetic" patient. Deliberate over-correction has not been reported to our knowledge. This article presents a combination of distraction osteogenesis and lyophilized cartilage used to three-dimensionally over-augment the mandibular angle of a long-face prognathic patient who had the wish to be morphed to Michael Jackson or at least as far as current technique and his endogenic features allowed.

The Future of Professional Development Will Be Designed, Not Discovered: Response to Moon, Passmore, Reiser, and Michaels, "Beyond Comparisons of Online versus Face-to-Face PD"

ERIC Educational Resources Information Center

Fishman, Barry; Konstantopoulos, Spyros; Kubitskey, Beth W.; Vath, Richard; Park, Gina; Johnson, Heather; Edelson, Daniel

2014-01-01

This article represents a response to the authors' "Journal of Teacher Education" ("JTE") article (Fishman et al., 2013) by Moon, Passmore, Reiser, and Michaels (2013). The authors believe that Moon et al. have properly identified both the value in their study and the importance of moving beyond not only their study, but…

Honors

NASA Astrophysics Data System (ADS)

Anonymous

2013-07-01

The Geological Society of America's (GSA) new class of medal and award recipients and fellows includes many AGU members. Medal and award recipients are Stephen G. Pollock, University of Southern Maine: GSA Distinguished Service Award; John R. Wheaton, Montana Bureau of Mines and Geology: John C. Frye Award; Clifford A. Jacobs, National Science Foundation (NSF): Outstanding Contributions Award, Geoinformatics Division; Peter Bird, University of California, Los Angeles (emeritus): George P. Woollard Award, Geophysics Division; Chunmiao Zheng, University of Alabama: O. E. Meinzer Award, Hydrogeology Division; Gerhard Wörner, Georg August Universität Göttingen: Distinguished Geologic Career Award, Mineralogy, Geochemistry, Petrology, and Volcanology Division; Alan D. Howard, University of Virginia: G. K. Gilbert Award, Planetary Geology Division; Michael E. Perkins, University of Utah: Kirk Bryan Award for Research Excellence, Quaternary Geology and Geomorphology Division; and Peter J. Hudleston, University of Minnesota: Career Contribution Award, Structural Geology and Tectonics Division.

Mathematical Modelling of Liner Piston Maintenance Activity using Field Data to Minimize Overhauling Time and Human Energy Consumption

NASA Astrophysics Data System (ADS)

Belkhode, Pramod Namdeorao

2017-06-01

Field data based model is proposed to reduce the overhauling time and human energy consumed in liner piston maintenance activity so as to increase the productivity of liner piston maintenance activity. The independent variables affecting the phenomenon such as anthropometric parameters of workers (Eastman Kodak Co. Ltd in Section VIA Appendix-A: Anthropometric Data. Ergonomic Design for People at Work, Van Nostrans Reinhold, New York, 1), workers parameters, specification of liner piston data, specification of tools used in liner piston maintenance activity, specification of solvents, axial clearance of big end bearing and bolt elongation, workstation data (Eastman Kodak Co. Ltd in Work Place Ergonomic Design for People at Work, Van Nostrans Reinhold, New York, 2) and extraneous variables, namely, temperature, humidity at workplace, illumination at workplace and noise at workplace (Eastman Kodak Co. Ltd in Chapter V Environment Ergonomic Design for People at Work, Van Nostrans Reinhold, New York, 3) are taken into account. The model is formulated for dependent variables of liner piston maintenance activity to minimize the overhauling time and human energy consumption so as to improve the productivity of liner piston maintenance activity. The developed model can predict the performance of liner piston maintenance activity which involves man and machine system (Schenck in Theories of Engineering Experimentation, Mc-Graw Hill, New York 4). The model is then optimized by optimization technique and the sensitivity analysis of the model has also been estimated.

What We Know about Adolescents' Out-of-School Literacies, What We Need to Learn, and Why Studying Them Is Important: An Interview with Michael W. Smith

ERIC Educational Resources Information Center

Smith, Michael W.; Moore, David W.

2012-01-01

Michael W. Smith, a professor in Temple University's College of Education, focuses his research on how experienced readers read and talk about texts as well as what motivates adolescents' reading and writing in and out of school. He sees the recent research on adolescents' out-of-school literacies as a challenge to literacy educators to look at…

On the Origin of Nonmare Materials at the Apollo 12 Landing Site

NASA Technical Reports Server (NTRS)

Jolliff, B. L.; Gillis, J. J.; Korotev, R. L.; Haskin, L. A.

2000-01-01

Sources of nonmare material at the Apollo 12 site are investigated using remotely sensed FeO and Th data and measured soil compositions. Copernicus ray ejecta, Reinhold ejecta, and vertical gardening of buried crater ejecta (Lansberg) are evaluated.

STS-42 Payload Specialist Merbold inside KC-135 during zero gravity flight

NASA Image and Video Library

1988-05-24

S88-37966 (2 Oct 1988) --- European Space Agency payload specialists Ulf Merbold (STS-42, right) and Reinhold Furrer (STS 61-A) get the "feel" of zero-gravity aboard NASA's KC-135 aircraft over the Gulf of Mexico.

Optimization of the β-Elimination/Michael Addition Chemistry on Reversed-Phase Supports for Mass Spectrometry Analysis of O-Linked Protein Modifications

PubMed Central

Nika, Heinz; Nieves, Edward; Hawke, David H.; Angeletti, Ruth Hogue

2013-01-01

We previously adapted the β-elimination/Michael addition chemistry to solid-phase derivatization on reversed-phase supports, and demonstrated the utility of this reaction format to prepare phosphoseryl peptides in unfractionated protein digests for mass spectrometric identification and facile phosphorylation-site determination. Here, we have expanded the use of this technique to β-N-acetylglucosamine peptides, modified at serine/threonine, phosphothreonyl peptides, and phosphoseryl/phosphothreonyl peptides, followed in sequence by proline. The consecutive β-elimination with Michael addition was adapted to optimize the solid-phase reaction conditions for throughput and completeness of derivatization. The analyte remained intact during derivatization and was recovered efficiently from the silica-based, reversed-phase support with minimal sample loss. The general use of the solid-phase approach for enzymatic dephosphorylation was demonstrated with phosphoseryl and phosphothreonyl peptides and was used as an orthogonal method to confirm the identity of phosphopeptides in proteolytic mixtures. The solid-phase approach proved highly suitable to prepare substrates from low-level amounts of protein digests for phosphorylation-site determination by chemical-targeted proteolysis. The solid-phase protocol provides for a simple, robust, and efficient tool to prepare samples for phosphopeptide identification in MALDI mass maps of unfractionated protein digests, using standard equipment available in most biological laboratories. The use of a solid-phase analytical platform is expected to be readily expanded to prepare digest from O-glycosylated- and O-sulfonated proteins for mass spectrometry-based structural characterization. PMID:23997661

Adam's Rage: Children of the Pinelands Speak: The Michael L. Printz Award Winning Novels: Authentic Current Literature as a Catalyst for Increased Student Growth, Motivation and Healing

ERIC Educational Resources Information Center

Cecchini, Stephanie Anne

2012-01-01

Young adults deserve our best as parents, educators and community members. The Michael L. Printz award winning books, instituted by the Young Adult Library Association, form a recent grouping of current literature. Novels worthy of the Printz Award explore physical, emotional, and social themes important in the lives of young adults. This library…

Principles of Chemistry (by Michael Munowitz)

NASA Astrophysics Data System (ADS)

Kovac, Reviewed By Jeffrey

2000-05-01

At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

Crystallisation and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael-acceptor inhibitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coates, Leighton; Cooper, Jon; Hussey, Robert

2008-01-01

Noroviruses are the predominant cause of human epidemic nonbacterial gastroenteritis. Viral replication requires a cysteine protease that cleaves a 200 kDa viral polyprotein into its constituent functional parts. Here, the crystallization of the recombinant protease from the Southampton norovirus is described. While the native crystals were found to diffract only to medium resolution (2.9 {angstrom}), cocrystals of an inhibitor complex diffracted X-rays to 1.7 {angstrom} resolution. The polypeptide inhibitor (Ac-EFQLQ-propenyl ethyl ester) possesses an amino-acid sequence designed to match the substrate specificity of the enzyme, but was synthesized with a reactive Michael acceptor group at the C-terminal end.

The economic role of the Emergency Department in the health care continuum: applying Michael Porter's five forces model to Emergency Medicine.

PubMed

Pines, Jesse M

2006-05-01

Emergency Medicine plays a vital role in the health care continuum in the United States. Michael Porters' five forces model of industry analysis provides an insight into the economics of emergency care by showing how the forces of supplier power, buyer power, threat of substitution, barriers to entry, and internal rivalry affect Emergency Medicine. Illustrating these relationships provides a view into the complexities of the emergency care industry and offers opportunities for Emergency Departments, groups of physicians, and the individual emergency physician to maximize the relationship with other market players.

STS-109 Astronaut Michael J. Massimino Peers Into Window of Shuttle During EVA

NASA Technical Reports Server (NTRS)

2002-01-01

STS-109 Astronauts Michael J. Massimino and James H. Newman were making their second extravehicular activity (EVA) of their mission when astronaut Massimino, mission specialist, peered into Columbia's crew cabin during a brief break from work on the Hubble Space Telescope (HST). The HST is latched down just a few feet behind him in Columbia's cargo bay. The Space Shuttle Columbia STS-109 mission lifted off March 1, 2002 with goals of repairing and upgrading the Hubble Space Telescope (HST). STS-109 upgrades to the HST included: replacement of the solar array panels; replacement of the power control unit (PCU); replacement of the Faint Object Camera (FOC) with a new advanced camera for Surveys (ACS); and installation of the experimental cooling system for the Hubble's Near-Infrared Camera and Multi-object Spectrometer (NICMOS), which had been dormant since January 1999 when its original coolant ran out. The Marshall Space Flight Center in Huntsville, Alabama had the responsibility for the design, development, and construction of the HST, which is the most powerful and sophisticated telescope ever built. Lasting 10 days, 22 hours, and 11 minutes, the STS-109 mission was the 108th flight overall in NASA's Space Shuttle Program.

Asymmetric organocatalyzed Michael addition of nitromethane to a 2-oxoindoline-3-ylidene acetaldehyde and the three one-pot sequential synthesis of (-)-horsfiline and (-)-coerulescine.

PubMed

Mukaiyama, Takasuke; Ogata, Kento; Sato, Itaru; Hayashi, Yujiro

2014-10-13

(-)-Horsfiline and (-)-coerulescine were synthesized through three one-pot operations in 33 and 46% overall yield, respectively. Key to the success was the efficient use of a diarylprolinol silyl ether to catalyze the asymmetric Michael addition of nitromethane to a 2-oxoindoline-3-ylidene acetaldehyde. This allowed the all-carbon quaternary, spirocyclic carbon stereocenter to be constructed in good yield with excellent enantioselectivity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Facile and Promising Method for Michael Addition of Indole and Pyrrole to Electron-Deficient trans-β-Nitroolefins Catalyzed by a Hydrogen Bond Donor Catalyst Feist's Acid and Preliminary Study of Antimicrobial Activity

PubMed Central

Al Majid, Abdullah M. A.; Islam, Mohammad Shahidul; Barakat, Assem; Al-Agamy, Mohamed H. M.; Naushad, Mu.

2014-01-01

The importance of cooperative hydrogen-bonding effects has been demonstrated using novel 3-methylenecyclopropane-1,2-dicarboxylic acid (Feist's acid (FA)) as hydrogen bond donor catalysts for the addition of indole and pyrrole to trans-β-nitrostyrene derivatives. Because of the hydrogen bond donor (HBD) ability, Feist's acid (FA) has been introduced as a new class of hydrogen bond donor catalysts for the activation of nitroolefin towards nucleophilic substitution reaction. It has effectively catalyzed the Michael addition of indoles and pyrrole to β-nitroolefins under optimum reaction condition to furnish the corresponding Michael adducts in good to excellent yields (up to 98%). The method is general, atom-economical, convenient, and eco-friendly and could provide excellent yields and regioselectivities. Some newly synthesized compounds were for examined in vitro antimicrobial activity and their preliminary results are reported. PMID:24574906

Searching phase II enzymes inducers, from Michael acceptor-[1,2]dithiolethione hybrids, as cancer chemopreventive agents.

PubMed

Couto, Marcos; de Ovalle, Stefani; Cabrera, Mauricio; Cerecetto, Hugo; González, Mercedes

2015-01-01

Cancer chemoprevention involves the carcinogenic process prevention, delay or reverse by the administration of chemopreventive agents, which are able to suppress or block the carcinogen metabolic activation/formation. The increased activity of phase II detoxification enzymes such as quinone-reductase (QR) and glutation-S-transferase (GST) correlates with the protection against chemically-induced carcinogenesis. It has been shown that synthetic chalcones and 3H-[1,2]-dithiole-3-thiones promote expression of genes involved in chemoprevention. Herein, the induction of phase II enzymes by designed Michael acceptor-dithiolethione hybrids was studied. Hybrids 5 and 7 displayed the induction of quinone-reductase and glutation-S-transferase in vitro in the same order on the wild-type mouse-hepatoma Hepa 1c1c7 and on the aryl-hydrocarbon-nuclear-translocator (Arnt)-defective mutant BPrc1 cells indicating that 7 displays the best chemopreventive potential.

An inventory survey at the site of the proposed Kilauea Middle East Rift Zone (KMERZ), Well Site No. 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kennedy, Joseph

1991-03-01

At the request of True Mid Pacific Geothermal, Archaeological Consultants of Hawaii, Inc. has conducted an inventory survey at the site of the proposed Kilauea Middle East Rift Zone (KMERZ), Well Site No.2, TMK: 1-2-10:3. The Principal Investigator was Joseph Kennedy M.A., assisted by Jacob Kaio, Field Supervisor and field crew Mark Borrello B.A., Michael O'Shaughnessy B.A., and Randy Adric. This report supercedes all previous reports submitted to the Historic Presentation Section of the Department of Land and Natural Resources. In addition to 100% surface coverage of the 400 x 400 foot well pad itself, 100% surface coverage of amore » substantial buffer zone was also completed. This buffer zone was established by the Department of Land and Natural Resources, Historic Preservation personnel and extends 1000 feet east and west of the well site and 500 feet north and south of the well site.« less

International trade and waste and fuel management issue, 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnihotri, Newal

The focus of the January-February issue is on international trade and waste and fuel managment. Major articles/reports in this issue include: Innovative financing and workforce planning, by Donna Jacobs, Entergy Nuclear; Nuclear power - a long-term need, by John C. Devine, Gerald Goldsmith and Michael DeLallo, WorleyParsons; Importance of loan guarantee program, by Donald Hintz; EPC contracts for new plants, by Dave Barry, Shaw Power Group; GNEP and fuel recycling, by Alan Hanson, AREVA NC Inc.; Safe and reliable reactor, by Kiyoshi Yamauchi, Mitsubishi Heavy Industries, Ltd.; Safe, small and simple reactors, by Yoshi Sakashita, Toshiba Corporation; Nuclear power inmore » Thailand, by Tatchai Sumitra, Thailand Institute of Nuclear Technology; and, Nuclear power in Vietnam, by Tran Huu Phat, Vietnam Atomic Energy Commission. The Industry Innovation article this issue is Rectifying axial-offset-anomaly problems, by Don Adams, Tennessee Valley Authority. The Plant Profile article is Star of Stars Excellence, by Tyler Lamberts, Entergy Nuclear Operations, Inc.« less

78 FR 73568 - Senior Executive Service-Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

... Coleman, Chief Financial Officer Joseph Kennedy, Associate Director for Human Resources Solutions Mark Reinhold, Chief Human Capital Officer and Acting Associate Director for Employee Services [FR Doc. 2013... Management: Ann Marie Habershaw, Chief of Staff Angela Bailey, Chief Operating Officer Elizabeth Montoya...

Successful treatment of facial systemic lupus erythematosus lesions with Dr Michaels® (Soratinex®) product family. A case report.

PubMed

Tirant, M; Bayer, P; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

2016-01-01

Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain and other organs. We report the case of a 7-year-old female patient with facial lesions of SLE since the age of 5. There was no significant family history and patient had been a healthy child from birth. The child presented with a malar rash, also known as a butterfly rash, with distribution over the cheeks but sparing the nasal bridge. This case represents the efficacy of the Dr. Michaels® (Soratinex®) product family in the successful resolution of facial lesions of SLE.

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Lewis acid-Lewis acid heterobimetallic cooperative catalysis: mechanistic studies and application in enantioselective aza-Michael reaction.

PubMed

Yamagiwa, Noriyuki; Qin, Hongbo; Matsunaga, Shigeki; Shibasaki, Masakatsu

2005-09-28

The full details of a catalytic asymmetric aza-Michael reaction of methoxylamine promoted by rare earth-alkali metal heterobimetallic complexes are described, demonstrating the effectiveness of Lewis acid-Lewis acid cooperative catalysis. First, enones were used as substrates, and the 1,4-adducts were obtained in good yield (57-98%) and high ee (81-96%). Catalyst loading was successfully reduced to 0.3-3 mol % with enones. To broaden the substrate scope of the reaction to carboxylic acid derivatives, alpha,beta-unsaturated N-acylpyrroles were used as monodentate, carboxylic acid derivatives. With beta-alkyl-substituted N-acylpyrroles, the reaction proceeded smoothly and the products were obtained in high yield and good ee. Transformation of the 1,4-adducts from enones and alpha,beta-unsaturated N-acylpyrroles afforded corresponding chiral aziridines and beta-amino acids. Detailed mechanistic studies, including kinetics, NMR analysis, nonlinear effects, and rare earth metal effects, are also described. The Lewis acid-Lewis acid cooperative mechanism, including the substrate coordination mode, is discussed in detail.

Michael Jackson, Bin Laden and I: functions of positive and negative, public and private flashbulb memories.

PubMed

Demiray, Burcu; Freund, Alexandra M

2015-01-01

This study examined the perceived psychosocial functions of flashbulb memories: It compared positive and negative public flashbulb memories (positive: Bin Laden's death, negative: Michael Jackson's death) with private ones (positive: pregnancy, negative: death of a loved one). A sample of n = 389 young and n = 176 middle-aged adults answered canonical category questions used to identify flashbulb memories and rated the personal significance, the psychological temporal distance, and the functions of each memory (i.e., self-continuity, social-boding, directive functions). Hierarchical regressions showed that, in general, private memories were rated more functional than public memories. Positive and negative private memories were comparable in self-continuity and directionality, but the positive private memory more strongly served social functions. In line with the positivity bias in autobiographical memory, positive flashbulb memories felt psychologically closer than negative ones. Finally, middle-aged adults rated their memories as less functional regarding self-continuity and social-bonding than young adults. Results are discussed regarding the tripartite model of autobiographical memory functions.

Enzyme-catalyzed Michael addition for the synthesis of warfarin and its determination via fluorescence quenching of L-tryptophan

NASA Astrophysics Data System (ADS)

Yuan, Yusheng; Yang, Liu; Liu, Shaopu; Yang, Jidong; Zhang, Hui; Yan, Jingjing; Hu, Xiaoli

2017-04-01

A sensitive fluorescence sensor for warfarin was proposed via quenching the fluorescence of L-tryptophan due to the interaction between warfarin and L-tryptophan. Warfarin, as one of the most effective anticoagulants, was designed and synthesized via lipase from porcine pancreas (PPL) as a biocatalyst to catalyze the Michael addition of 4-hydroxycoumarin to α, β-unsaturated enones in organic medium in the presence of water. Furthermore, the spectrofluorometry was used to detect the concentration of warfarin with a linear range and detection limit (3σ/k) of 0.04-12.0 μmol L- 1 (R2 = 0.994) and 0.01 μmol L- 1, respectively. Herein, this was the first application of bio-catalytic synthesis and fluorescence for the determination of warfarin. The proposed method was applied to determine warfarin of the drug in tablets with satisfactory results.

Part 3. a novel stereocontrolled, in situ, solution- and solid-phase, Aza Michael approach for high-throughput generation of tetrahydroaminoquinoline-derived natural-product-like architectures.

PubMed

Prakesch, Michael; Srivastava, Stuti; Leek, Donald M; Arya, Prabhat

2006-01-01

With the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.

Investigation of Laser-Induced Retinal Damage: Wavelength and Pulsewidth Dependent Mechanisms

DTIC Science & Technology

1994-06-30

Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991;1072:129-57. 2. Artuc M, Ramshad M, Kappus H. Studies...M, Reinhold C, Kappus H. DNA damage caused by laser light activated hematoporphyrin derivatives in isolated nuclei of human melanoma cells. Arch

Assessing System Architectures: The Canonical Decomposition Fuzzy Comparative Methodology

DTIC Science & Technology

2011-01-01

me. Thank you to my sisters, Vanessa and Valerie, for their support and for putting up with me while we were growing up. Finally and most...Antenna Handbook Theory, Applications, and Deign. New York: Van Nostrand Reinhold. 85 Maier, M. W. and E. Rechtin. 2002. The Art of Systems

Racemic hemiacetals as oxygen-centered pronucleophiles triggering cascade 1,4-addition/Michael reaction through dynamic kinetic resolution under iminium catalysis. Development and mechanistic insights† †Electronic supplementary information (ESI) available: Detailed experimental procedures and characterization of all new compounds, including copies of NMR spectra and HPLC chromatograms traces, computational details and Cartesian coordinates of all stationary points. CCDC 1525188 (4l), 1525189 (6a) and 1525190 (9a). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00009j Click here for additional data file. Click here for additional data file.

PubMed Central

Orue, Ane; Uria, Uxue; Roca-López, David; Delso, Ignacio; Reyes, Efraím; Carrillo, Luisa

2017-01-01

2-Hydroxydihydropyran-5-ones behave as excellent polyfunctional reagents able to react with enals through oxa-Michael/Michael process cascade under the combination of iminium and enamine catalysis. These racemic hemiacetalic compounds are used as unconventional O-pronucleophiles in the initial oxa-Michael reaction, also leading to the formation of a single stereoisomer under a dynamic kinetic resolution (DKR) process. Importantly, by using β-aryl or β-alkyl substituted α,β-unsaturated substrates as initial Michael acceptors either kinetically or thermodynamically controlled diastereoisomers were formed with high stereoselection through the careful selection of the reaction conditions. Finally, a complete experimental and computational study confirmed the initially proposed DKR process during the catalytic oxa-Michael/Michael cascade reaction and also explained the kinetic/thermodynamic pathway operating in each case. PMID:28451356

Reply to discussion by Michael A. Collins, "Fresh ground water stored in aquifers under the continental shelf: implications from a deep test, Nantucket Island, Massachusetts"

USGS Publications Warehouse

Kohout, F.A.; Delaney, D.F.

1979-01-01

We appreciate the comments made in the discussion by Michael A. Collins, regarding our paper about the anomalously low salinity of water underlying Nantucket Island. However, we feel that in his effort to justify the mathematical approach for solving salt water intrusion problems, he has overlooked several of the major points in this paper. We will try to amplify these points to establish that, indeed, the situation at Nantucket is anomalous, contrary to Collins’ negative conclusion (Collins, 1978).

An unusual Michael-induced skeletal rearrangement of a bicyclo[3.3.1]nonane framework of phloroglucinols to a novel bioactive bicyclo[3.3.0]octane.

PubMed

Vidali, Veroniki P; Mitsopoulou, Kornilia P; Dakanali, Marianna; Demadis, Konstantinos D; Odysseos, Andreani D; Christou, Yiota A; Couladouros, Elias A

2013-11-01

A novel skeletal rearrangement of bicyclo[3.3.1]nonane-2,4,9-trione (16) to an unprecedented highly functionalized bicyclo[3.3.0]octane system (17), induced by an intramolecular Michael addition, is presented. This novel framework was found to be similarly active to hyperforin (1), against PC-3 cell lines. A mechanistic study was examined in detail, proposing a number of cascade transformations. Also, reactivity of the Δ(7,10)-double bond was examined under several conditions to explain the above results.

Investigation of Laser-Induced Retinal Damage: Wavelength and Pulsewidth Dependent Mechanisms

DTIC Science & Technology

1994-08-31

transformation. Biochim Biophys Acta 1991; 1072:129-57. 2. Artuc M, Ramshad M, Kappus H. Studies on acute toxic effects to keratinocytes induced by...hematoporphyrin derivatives and laser light Arch Dermatol Res 1989;281:491-4. 3. Artuc M, Ramshad M, Reinhold C, Kappus H. DNA damage caused by laser light

Mother's love' for bacterial babies: the commitment of Audrey Michael, Mition Yoannes and Tilda Orami to medical research.

PubMed

Gibbs, Tammy; Vilakiva, Geraldine

2013-01-01

Audrey Michael, Mition Yoannes and Tilda Orami are long-term health researchers at the Papua New Guinea Institute of Medical Research (PNGIMR). Face-to-face interviews were conducted with all three women for the purpose of profiling women who are leaders in health and medicine in Papua New Guinea. They were asked questions about their early life and childhood, education, work life and training, and mentors who have supported their career path and leadership role. Audrey, Mition and Tilda have all made significant contributions to the PNGIMR and to the health of the people of PNG. In particular, all three have been part of pneumococcal conjugate vaccine (PCV) studies--looking at the safety, immunogenicity and priming for immunological memory of a 7-valent PCV and investigating the safety and immune responses to two different, recently licensed types of PCV, a 13-valent and a 10-valent vaccine.

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

PubMed

Freedy, Allyson M; Matos, Maria J; Boutureira, Omar; Corzana, Francisco; Guerreiro, Ana; Akkapeddi, Padma; Somovilla, Víctor J; Rodrigues, Tiago; Nicholls, Karl; Xie, Bangwen; Jiménez-Osés, Gonzalo; Brindle, Kevin M; Neves, André A; Bernardes, Gonçalo J L

2017-12-20

Chemical modification of proteins is essential for a variety of important diagnostic and therapeutic applications. Many strategies developed to date lack chemo- and regioselectivity as well as result in non-native linkages that may suffer from instability in vivo and adversely affect the protein's structure and function. We describe here the reaction of N-nucleophiles with the amino acid dehydroalanine (Dha) in a protein context. When Dha is chemically installed in proteins, the addition of a wide-range N-nucleophiles enables the rapid formation of amine linkages (secondary and tertiary) in a chemoselective manner under mild, biocompatible conditions. These new linkages are stable at a wide range of pH values (pH 2.8 to 12.8), under reducing conditions (biological thiols such as glutathione) and in human plasma. This method is demonstrated for three proteins and is shown to be fully compatible with disulfide bridges, as evidenced by the selective modification of recombinant albumin that displays 17 structurally relevant disulfides. The practicability and utility of our approach is further demonstrated by the construction of a chemically modified C2A domain of Synaptotagmin-I protein that retains its ability to preferentially bind to apoptotic cells at a level comparable to the native protein. Importantly, the method was useful for building a homogeneous antibody-drug conjugate with a precise drug-to-antibody ratio of 2. The kinase inhibitor crizotinib was directly conjugated to Dha through its piperidine motif, and its antibody-mediated intracellular delivery results in 10-fold improvement of its cancer cell-killing efficacy. The simplicity and exquisite site-selectivity of the aza-Michael ligation described herein allows the construction of stable secondary and tertiary amine-linked protein conjugates without affecting the structure and function of biologically relevant proteins.

KENNEDY SPACE CENTER, FLA. -- Sandra Anderson, wife of STS-107 Payload Commander Michael Anderson, visits a new residence hall at the Florida Institute of Technology (FIT) in Melbourne, Fla., named for her late husband. Family members of the STS-107 astronauts, other dignitaries, members of the university community and the public gathered for a dedication ceremony for the Columbia Village at FIT. Each of the seven new residence halls in the complex is named for one of the STS-107 astronauts who perished during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon.

NASA Image and Video Library

2003-10-28

KENNEDY SPACE CENTER, FLA. -- Sandra Anderson, wife of STS-107 Payload Commander Michael Anderson, visits a new residence hall at the Florida Institute of Technology (FIT) in Melbourne, Fla., named for her late husband. Family members of the STS-107 astronauts, other dignitaries, members of the university community and the public gathered for a dedication ceremony for the Columbia Village at FIT. Each of the seven new residence halls in the complex is named for one of the STS-107 astronauts who perished during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon.

Stennis group receives NESC award

NASA Image and Video Library

2009-04-14

The NASA Engineering & Safety Center recently presented its Group Achievement Award to a Stennis team in recognition of technical excellence in evaluating the operational anomalies and reliability improvements associated with the space shuttle engine cut-off system. Stennis employees receiving the award were: (standing, l to r) Freddie Douglas (NASA), George Drouant (Jacobs Technology Inc.), Fred Abell (Jacobs), Robert Drackett (Jacobs) and Mike Smiles (NASA); (seated, l to r): Binh Nguyen (Jacobs), Stennis Director Gene Goldman and Joseph Lacker (NASA). Phillip Hebert of NASA is not pictured.

Stennis group receives NESC award

NASA Technical Reports Server (NTRS)

2009-01-01

The NASA Engineering & Safety Center recently presented its Group Achievement Award to a Stennis team in recognition of technical excellence in evaluating the operational anomalies and reliability improvements associated with the space shuttle engine cut-off system. Stennis employees receiving the award were: (standing, l to r) Freddie Douglas (NASA), George Drouant (Jacobs Technology Inc.), Fred Abell (Jacobs), Robert Drackett (Jacobs) and Mike Smiles (NASA); (seated, l to r): Binh Nguyen (Jacobs), Stennis Director Gene Goldman and Joseph Lacker (NASA). Phillip Hebert of NASA is not pictured.

Summiteers--Moving Mountains with Bereaved Boys

ERIC Educational Resources Information Center

Renner, Hans-Georg

2011-01-01

Summiteers are people who rush to the top. There is a mountain summit and a metaphorical summit inside us which we can climb. In the area of mountain summits, Reinhold Messner is surely the best known and most successful summiteer. He climbed, among other things, the highest peak on earth without supplemental oxygen. In the language of the country…

Make Learning Stick: Best Practices to Get the Most Out of Leadership Development

ERIC Educational Resources Information Center

Reinhold, Diane; Patterson, Tracy; Hegel, Peter

2015-01-01

In this white paper, Diane Reinhold, Tracy Patterson, and Peter Hegel assert that there is no magic bullet to ensure people apply what they learn. There are, however, steps that can be taken to create leadership programs, experiences, and supports that improve the likelihood that lessons will be learned and applied. Over time, new skills,…

A Short History of Probability Theory and Its Applications

ERIC Educational Resources Information Center

Debnath, Lokenath; Basu, Kanadpriya

2015-01-01

This paper deals with a brief history of probability theory and its applications to Jacob Bernoulli's famous law of large numbers and theory of errors in observations or measurements. Included are the major contributions of Jacob Bernoulli and Laplace. It is written to pay the tricentennial tribute to Jacob Bernoulli, since the year 2013…

Solid State Ionics: from Michael Faraday to green energy-the European dimension.

PubMed

Funke, Klaus

2013-08-01

Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag 2 S and PbF 2 and coined terms such as cation and anion , electrode and electrolyte . In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an 'evolving scheme of materials science', point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987.

Solid State Ionics: from Michael Faraday to green energy—the European dimension

PubMed Central

Funke, Klaus

2013-01-01

Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an ‘evolving scheme of materials science’, point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987. PMID:27877585

Astronaut Robinson presents 2010 Silver Snoopy awards

NASA Image and Video Library

2010-06-23

NASA's John C. Stennis Space Center Director Patrick Scheuermann and astronaut Steve Robinson stand with recipients of the 2010 Silver Snoopy awards following a June 23 ceremony. Sixteen Stennis employees received the astronauts' personal award, which is presented by a member of the astronaut corps representing its core principles for outstanding flight safety and mission success. This year's recipients and ceremony participants were: (front row, l to r): Cliff Arnold (NASA), Wendy Holladay (NASA), Kendra Moran (Pratt & Whitney Rocketdyne), Mary Johnson (Jacobs Technology Facility Operating Services Contract group), Cory Beckemeyer (PWR), Dean Bourlet (PWR), Cecile Saltzman (NASA), Marla Carpenter (Jacobs FOSC), David Alston (Jacobs FOSC); (back row, l to r) Scheuermann, Don Wilson (A2 Research), Tim White (NASA), Ira Lossett (Jacobs Technology NASA Test Operations Group), Kerry Gallagher (Jacobs NTOG); Rene LeFrere (PWR), Todd Ladner (ASRC Research and Technology Solutions) and Thomas Jacks (NASA).

Michael Addition Reactions between Chiral Equivalents of a Nucleophilic Glycine and (S)- or (R)-3-[(E)-Enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a General Method for Efficient Preparation of β-Substituted Pyroglutamic Acids. Case of Topographically Controlled Stereoselectivity

PubMed Central

Soloshonok*, Vadim A.; Cai, Chaozhong; Yamada, Takeshi; Ueki, Hisanori; Ohfune, Yasufumi; Hruby, Victor J.

2006-01-01

This paper describes a systematic study of addition reactions between the chiral Ni(II) complex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general and synthetically efficient approach to β-substituted pyroglutamic acids and relevant compounds. These reactions were shown to occur at room temperature in the presence of nonchelating organic bases and, most notably, with very high (>98% diastereomeric excess (de)) stereoselectivity at both newly formed stereogenic centers. The stereochemical outcome of the reactions was found to be overwhelmingly controlled by the stereochemical preferences of the Michael acceptors, and the chirality of the glycine complex influenced only the reaction rate. Thus, in the reactions of both the (S)-configured Ni(II) complex and the Michael acceptors, the reaction rates were exceptionally high, allowing preparation of the corresponding products with virtually quantitative (>98%) chemical and stereochemical yields. In contrast, reactions of the (S)-configured Ni(II) complex and (R)-configured Michael acceptors proceeded at noticeably lower rates, but the addition products were obtained in high diastereo-and enantiomeric purity. To rationalize the remarkably high and robust stereoselectivity observed in these reactions, we consider an enzyme–substrate-like mode of interaction involing a topographical match or mismatch of two geometric figures. Excellent chemical and stereochemical yields, combined with the simplicity and operational convenience of the experimental procedures, render the present method of immediate use for preparing various β-substituted pyroglutamic acids and related compounds. PMID:16248672

Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity.

PubMed

Soloshonok, Vadim A; Cai, Chaozhong; Yamada, Takeshi; Ueki, Hisanori; Ohfune, Yasufumi; Hruby, Victor J

2005-11-02

This paper describes a systematic study of addition reactions between the chiral Ni(II) complex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general and synthetically efficient approach to beta-substituted pyroglutamic acids and relevant compounds. These reactions were shown to occur at room temperature in the presence of nonchelating organic bases and, most notably, with very high (>98% diastereomeric excess (de)) stereoselectivity at both newly formed stereogenic centers. The stereochemical outcome of the reactions was found to be overwhelmingly controlled by the stereochemical preferences of the Michael acceptors, and the chirality of the glycine complex influenced only the reaction rate. Thus, in the reactions of both the (S)-configured Ni(II) complex and the Michael acceptors, the reaction rates were exceptionally high, allowing preparation of the corresponding products with virtually quantitative (>98%) chemical and stereochemical yields. In contrast, reactions of the (S)-configured Ni(II) complex and (R)-configured Michael acceptors proceeded at noticeably lower rates, but the addition products were obtained in high diastereo- and enantiomeric purity. To rationalize the remarkably high and robust stereoselectivity observed in these reactions, we consider an enzyme-substrate-like mode of interaction involving a topographical match or mismatch of two geometric figures. Excellent chemical and stereochemical yields, combined with the simplicity and operational convenience of the experimental procedures, render the present method of immediate use for preparing various beta-substituted pyroglutamic acids and related compounds.

Reconfigurable Optical Directed-Logic Circuits

DTIC Science & Technology

2015-11-20

AFRL-AFOSR-VA-TR-2016-0053 Reconfigurable Optical Directed-Logic Circuits Jacob Robinson WILLIAM MARSH RICE UNIV HOUSTON TX Final Report 11/20/2015...2015 Reconfigurable Optical Directed-Logic Circuits FA9550-12-1-0261 FA9550-12-1-0261 Robinson, Jacob Rice University 6100 Main Street Houston...Optical Directed-Logic Circuits Jacob T. Robinson and Qianfan Xu Rice University 1. Motivation for Directed-Logic Circuits Directed-logic is

The Development of Mobile Augmented Reality

DTIC Science & Technology

2012-01-01

working jointly with NRL, performed a domain analysis ( Gabbard et al., 2002) to create a context for usability engineering effort, performed formative...rectangle to provide a background enabled the fastest user performance ( Gabbard et al., 2007). Tracking the user’s head position relative to the real...thank Yohan Baillot, Reinhold Behringer, Blaine Bell, Dennis Brown, Aaron Bryden, Enylton Coelho, Elliot Cooper-Balis, Deborah Hix, Joseph Gabbard

2015 Military Investigation and Justice Experience Survey (MIJES). Overview Report

DTIC Science & Technology

2016-03-16

FMG) b Defense Manpower Data Center (DMDC) a SRA International, Inc., A CSRA Company Defense Manpower Data Center 4800 Mark Center Drive, Suite... Manpower Data Center (DMDC) is indebted to numerous people for their assistance with the 2015 Military Investigation and Justice Experience Survey (2015...Statistical Analysis Macros to calculate the results presented in this report. Ms. Sue Reinhold provided assistance with programming and merging contact

Radar/Sonar and Time Series Analysis

DTIC Science & Technology

1991-06-27

Davis, William Dunsmuir Fourier and Likelihood Analysis in NMR Spectroscopy .......... David Brillinger and Reinhold Kaiser Resampling Techniques for...Zubelli. 2:30 pm Gunter Meyer The parabolic Fock theory for a convex dielectric Georgia Tech. scatterer Abstract: This talk deals with a high frequency...Lincoln Laboratory, MIT Jun 18 - Jun 29 Gunter Meyer Georgia Institute of Technology Jun 25 - Jun 29 Willard Miller University of Minnesota Ruth Miniowitz

Expedient Emergency Sanitation Measures

DTIC Science & Technology

1989-03-01

maintaining or restoring adequate sanitation in a widespread emergency. In the event of a major earthquake or nuclear attack, sewage collection and...sanitation in a widespread emergency. In the event of a major earthquake or nuclear attack, sewage collection and treatment systems, electric power and...Handbook of Chlorination, Von Nostrand Reinhold, New York, 1972, and Appendix C. 12 chlorine disinfection. The cysts of the protozoa Entamoeba

Multimedia and Audience: Implications for Executive Summaries

DTIC Science & Technology

1995-12-01

by the Institute for Defense Analysis ( Fetterman , 1993:123). As well, organizations such as Federal Express, IBM, and the U.S. Army have studied the...training compression, less delivery variance, better consistency of learning, and greater learning gains ( Fetterman , 1993:128-129). As defined previously... Fetterman , Roger L. and Satish K. Gupta. Mainstream Multimedia: Applying Multimedia in Business. New York: Van Nostrand Reinhold, 1993. Grice, Roger A

Applying a Hypoxia-Incorporating TCP Model to Experimental Data on Rat Sarcoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruggieri, Ruggero, E-mail: ruggieri.ruggero@gmail.com; Stavreva, Nadejda; Naccarato, Stefania

2012-08-01

Purpose: To verify whether a tumor control probability (TCP) model which mechanistically incorporates acute and chronic hypoxia is able to describe animal in vivo dose-response data, exhibiting tumor reoxygenation. Methods and Materials: The investigated TCP model accounts for tumor repopulation, reoxygenation of chronic hypoxia, and fluctuating oxygenation of acute hypoxia. Using the maximum likelihood method, the model is fitted to Fischer-Moulder data on Wag/Rij rats, inoculated with rat rhabdomyosarcoma BA1112, and irradiated in vivo using different fractionation schemes. This data set is chosen because two of the experimental dose-response curves exhibit an inverse dose behavior, which is interpreted as duemore » to reoxygenation. The tested TCP model is complex, and therefore, in vivo cell survival data on the same BA1112 cell line from Reinhold were added to Fischer-Moulder data and fitted simultaneously with a corresponding cell survival function. Results: The obtained fit to the combined Fischer-Moulder-Reinhold data was statistically acceptable. The best-fit values of the model parameters for which information exists were in the range of published values. The cell survival curves of well-oxygenated and hypoxic cells, computed using the best-fit values of the radiosensitivities and the initial number of clonogens, were in good agreement with the corresponding in vitro and in situ experiments of Reinhold. The best-fit values of most of the hypoxia-related parameters were used to recompute the TCP for non-small cell lung cancer patients as a function of the number of fractions, TCP(n). Conclusions: The investigated TCP model adequately describes animal in vivo data exhibiting tumor reoxygenation. The TCP(n) curve computed for non-small cell lung cancer patients with the best-fit values of most of the hypoxia-related parameters confirms previously obtained abrupt reduction in TCP for n < 10, thus warning against the adoption of severely hypofractionated

Dual-stream accounts bridge the gap between monkey audition and human language processing. Comment on "Towards a Computational Comparative Neuroprimatology: Framing the language-ready brain" by Michael Arbib

NASA Astrophysics Data System (ADS)

Garrod, Simon; Pickering, Martin J.

2016-03-01

Over the last few years there has been a resurgence of interest in dual-stream dorsal-ventral accounts of language processing [4]. This has led to recent attempts to bridge the gap between the neurobiology of primate audition and human language processing with the dorsal auditory stream assumed to underlie time-dependent (and syntactic) processing and the ventral to underlie some form of time-independent (and semantic) analysis of the auditory input [3,10]. Michael Arbib [1] considers these developments in relation to his earlier Mirror System Hypothesis about the origins of human language processing [11].

Polyphosphoester-Camptothecin Prodrug with Reduction-Response Prepared via Michael Addition Polymerization and Click Reaction.

PubMed

Du, Xueqiong; Sun, Yue; Zhang, Mingzu; He, Jinlin; Ni, Peihong

2017-04-26

Polyphosphoesters (PPEs), as potential candidates for biocompatible and biodegradable polymers, play an important role in material science. Various synthetic methods have been employed in the preparation of PPEs such as polycondensation, polyaddition, ring-opening polymerization, and olefin metathesis polymerization. In this study, a series of linear PPEs has been prepared via one-step Michael addition polymerization. Subsequently, camptothecin (CPT) derivatives containing disulfide bonds and azido groups were linked onto the side chain of the PPE through Cu(I)-catalyzed azidealkyne cyclo-addition "click" chemistry to yield a reduction-responsive polymeric prodrug P(EAEP-PPA)-g-ss-CPT. The chemical structures were characterized by nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared, ultraviolet-visible spectrophotometer, and high performance liquid chromatograph analyses, respectively. The amphiphilic prodrug could self-assemble into micelles in aqueous solution. The average particle size and morphology of the prodrug micelles were measured by dynamic light scattering and transmission electron microscopy, respectively. The results of size change under different conditions indicate that the micelles possess a favorable stability in physiological conditions and can be degraded in reductive medium. Moreover, the studies of in vitro drug release behavior confirm the reduction-responsive degradation of the prodrug micelles. A methyl thiazolyl tetrazolium assay verifies the good biocompatibility of P(EAEP-PPA) not only for normal cells, but also for tumor cells. The results of cytotoxicity and the intracellular uptake about prodrug micelles further demonstrate that the prodrug micelles can efficiently release CPT into 4T1 or HepG2 cells to inhibit the cell proliferation. All these results show that the polyphosphoester-based prodrug can be used for triggered drug delivery system in cancer treatment.

Morphological and molecular review of Jacob's Mountain Stream Keelback Opisthotropis jacobi Angel Bourret, 1933 (Squamata: Natricidae) with description of a sibling species from northern Vietnam.

PubMed

Ziegler, Thomas; David, Patrick; Ziegler, Tim N; Pham, Cuong T; Nguyen, Truong Q; Le, Minh D

2018-01-21

New morphological data including hemipenis morphology is provided for Opisthotropis jacobi, a poorly known Mountain Stream Keelback from Vietnam and China, based on three newly collected individuals from Sa Pa (Lao Cai Province) and Tam Dao (Vinh Phuc Province) in northern Vietnam. In addition, morphological data from Vietnam is summarized based on the original description (Angel Bourret 1933), on the overview book by Bourret (1936) and on a number of smaller, little-known contributions by the latter author along with re-examination of specimens deposited in the herpetological collection of the Muséum national d'Histoire naturelle, Paris. We also sequenced a fragment of the mitochondrial cytochrome b from the newly collected specimens of the Jacob's Mountain Stream Keelback and performed molecular analyses of new and existing data of the genus. A recently discovered Opisthotropis population from Tay Yen Tu Nature Reserve in Bac Giang Province, northern Vietnam, which at the first glance resembled O. jacobi morphologically, is shown to diverge both genetically and morphologically from the existing species and is herein described as a new species. Opisthotropis voquyi sp. nov. is characterized by the combination of the following characters: internasal not in contact with loreal; one preocular; usually two postoculars; one anterior temporal; one posterior temporal; 7 or 8, rarely 9 supralabials; 25 maxillary teeth; subcaudals 74-86; 15 dorsal scale rows at neck, at midbody and before vent; body scales smooth or only with few faint keels; and dorsal scales being greyish, greyish-brown or brown in preservative, posteriorly more or less edged with pale greyish-brown. Phylogenetically, the new species is supported as a sister taxon to O. jacobi, but the two taxa are approximately 10% divergent based on cytochrome b data.

The Effects of Stress on Levels of Nicotine in the Rat

DTIC Science & Technology

1990-03-01

nicotine (Benowitz & Jacob, 1985; Feyerabend & Russell, 1978; Fix, Daughton & Issenberg, 1986; Matsukura, Sakamoto, Takahashi, Matsuyama...circulating levels of nicotine ( Feyerabend & Russell, 1978; Rosenberg, Benowitz, Jacob & Wilson, 1980). These studies suggest that acidification of

A stale challenge to the philosophy of science: commentary on "Is psychology based on a methodological error?" by Michael Schwarz.

PubMed

Ruck, Nora; Slunecko, Thomas

2010-06-01

In his article "Is psychology based on a methodological error?" and based on a quite convincing empirical basis, Michael Schwarz offers a methodological critique of one of mainstream psychology's key test theoretical axioms, i.e., that of the in principle normal distribution of personality variables. It is characteristic of this paper--and at first seems to be a strength of it--that the author positions his critique within a frame of philosophy of science, particularly positioning himself in the tradition of Karl Popper's critical rationalism. When scrutinizing Schwarz's arguments, however, we find Schwarz's critique profound only as an immanent critique of test theoretical axioms. We raise doubts, however, as to Schwarz's alleged 'challenge' to the philosophy of science because the author not at all seems to be in touch with the state of the art of contemporary philosophy of science. Above all, we question the universalist undercurrent that Schwarz's 'bio-psycho-social model' of human judgment boils down to. In contrast to such position, we close our commentary with a plea for a context- and culture sensitive philosophy of science.

The Influence of Learning Strategies in the Acquisition, Retention, and Transfer of a Visual Tracking Task

DTIC Science & Technology

1979-08-01

Psychology, Psychoanalysis and Neurology X. N. Y.: Van Nostrand Reinhold, 1977. Craik , F. I. M., & Lockhart , R. S. Levels of processing : A framework for...Morris, C. D., & Stein, B. S. Some general constraints oil learning and memory research. In F. I. M. Craik & L. S. Cermak (Eds.), Levels of processing ... Craik & Lockhart , 1972; Craik & Tulving, 1975). Although the dependent measures differ, the conclusions drawn remain similar. Strategy usage has a

Radar/Sonar and Time Series Analysis

DTIC Science & Technology

1991-04-08

Fourier and Likelihood Analysis in NMR Spectroscopy .......... David Brillinger and Reinhold Kaiser Resampling Techniques for Stationary Time-series... Meyer The parabolic Fock theory foi a convex dielectric Georgia Tech. scatterer Abstract. This talk deals with a high frequency as) mptotic m~thod for...Malesky Inst. of Physics, Moscow Jun 11 - Jun 15 Victor P. Maslov MIEIM, USSR May 29 - Jun 15 Robert P. Meyer University of Wisconsin Jun 11 - Jun 15

Shipboard Tests of Halon 1301 Test Gas Simulants

DTIC Science & Technology

1990-08-22

Halon 1301 Test Gas Simulants," Memo Report, Naval Research Laboratory, Washington, DC, 1989. 8. Air Products and Chemicals , Inc ., "SF6 , An... Products and Chemicals , Inc ., "Specialty Gas Material Safety Data Sheet, Sulfur Hexafluoride " Air Products and Chemicals, Specialty Gas Department...34 Washington, DC, 1978. 11. N.I. Sax, Dangerous Properties of Industrial Materials, Sixth Edition, Van Nostrand Reinhold Company, New York, NY, 1984. 12. Air

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush at NASA Headquarters in Washington, D.C., stating his goals for NASA’s new mission: Completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

NASA Image and Video Library

2004-01-14

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush at NASA Headquarters in Washington, D.C., stating his goals for NASA’s new mission: Completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

77 FR 44678 - Kimberly-Clark Worldwide, Inc., a Subsidiary of Kimberly-Clark Corporation, Everett Mill...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

..., UNISEVE Corporation, Jacobs Engineering, STAFFLOGIX Corporation, and Swift Trucking,Everett, WA; Amended... Security Services, Healthforce, UNISEVE Corporation, and Jacobs Engineering, Everett, Washington. The... STAFFLOGIX Corporation. The subject firm produces tissue products and wood pulp. Following the allegation...

Coupled Thermo-Mechanical and Photo-Chemical Degradation Mechanisms that determine the Reliability and Operational Lifetimes for CPV Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dauskardt, Reinhold H.

This project sought to identify and characterize the coupled intrinsic photo-chemo-mechanical degradation mechanisms that determine the reliability and operational lifetimes for CPV technologies. Over a three year period, we have completed a highly successful program which has developed quantitative metrologies and detailed physics-based degradation models, providing new insight into the fundamental reliability physics necessary for improving materials, creating accelerated testing protocols, and producing more accurate lifetime predictions. The tasks for the program were separated into two focus areas shown in the figure below. Focus Area 1, led by Reinhold Dauskardt and Warren Cai with a primary collaboration with David Millermore » of NREL, studied the degradation mechanisms present in encapsulant materials. Focus Area 2, led by Reinhold Dauskardt and Ryan Brock with a primary collaboration with James Ermer and Peter Hebert of Spectrolab, studied stress development and degradation within internal CPV device interfaces. Each focus area was productive, leading to several publications, including findings on the degradation of silicone encapsulant under terrestrial UV, a model for photodegradation of silicone encapsulant adhesion, quantification and process tuning of antireflective layers on CPV, and discovery of a thermal cycling degradation mechanism present in metal gridline structures.« less

77 FR 8279 - Kimberly-Clark Worldwide, Inc., a Subsidiary of Kimberly-Clark Corporation, Everett Mill...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-14

..., Uniseve Corporation, Jacobs Engineering and Stafflogix Corporation, Everett, WA; Amended Certification... Services, Healthforce, UNISEVE Corporation and Jacobs Engineering, Everett, Washington. The workers are engaged in activities related to the production of tissue products (paper towels, toilet paper, wipes) and...

Obituary: Michael John Seaton, 1923-2007

NASA Astrophysics Data System (ADS)

Pradhan, Anil; Nahar, Sultana

2007-12-01

Professor Michael John Seaton, hailed as the "Father of Atomic Astrophysics," passed away on May 29, 2007. He was one of the few Honorary Fellows of both the American Astronomical Society and the American Physical Society, so honored for his monumental contributions to both physics and astronomy. Mike Seaton was born on January 16, 1923 in Bristol, England. He attended Wallington County High School. But his leftist political activities, even at that stage, led to his expulsion, though he was eventually allowed to matriculate. He enlisted in the Royal Air Force as a navigator during the Second World War, and flew many dangerous missions. His legendary concentration and precision are reflected in the following anecdote. Once after a bombing mission his aircraft was lost in fog over the Alps. Seaton calculated the position and coordinates in flight to guide the aircraft. When the fog lifted, the crew found themselves flying perilously close to the mountains, but made it safely back. His associates often said, "A Seaton calculation is carried out as if his life depended on it." After the War he was admitted to University College London (UCL) as an undergraduate. Thereafter, he spent all of his professional career at UCL. Seaton received his Batchelor's degree in 1948, and his Ph.D. in 1951. His tenure at UCL coincided with the golden age of atomic astrophysics, for he was largely responsible for it. Seaton was elected Fellow of the Royal Society in 1967, and as President of the Royal Astronomical Society (RAS) in 1978. He was the recipient of an Honorary Doctorate from the Observatoire de Paris, an Honorary D.Sc. from the Queen's University of Belfast, the Gold Medal for Astronomy by the RAS, the Guthrie Medal by the Institute of Physics, the Royal Society Hughes award for lifetime work by the RAS, and several other prestigious awards. Nevertheless, as Alex Dalgarno recently remarked, Seaton was not part of the establishment because he chose not to be. Though rooted in

Military Applications of Augmented Reality

DTIC Science & Technology

2011-01-01

Perception and Occlusion Representation Among the things our initial domain analysis [ Gabbard et al(2002)] indicated as a potential advantage for AR...Steven Feiner, Blaine Bell, Deborah Hix, Joseph L. Gabbard , Tobias Höllerer, Blair MacIntyre, Enylton Coelho, Ulrich Neumann, Suya You, Reinhold...Annual Meeting, Human Factors and Ergonomics Society, pp 48–52 [ Gabbard et al(2002)] Gabbard JL, Swan II JE, Hix D, Lanzagorta M, Livingston MA, Brown D

Physical Property Data Review of Selected Chemical Agents and Related Compounds: Updating Field Manual 3-9 (FM 3-9)

DTIC Science & Technology

2003-09-01

Ed.; Reinhold Book Corporation: New York, 1968. Daroff, P.M.; Metz, D.; Roberts, A.; Adams, J.A.; Jenkins, W. Oleoresin Capsicum : An Effective Less...Capsaicin, The Pungent Principle of Capsicum . III. J.Am. Chem. Soc. 1923, 45, p 2179. Newman, J.H., Edgewood Arsenal Notebook # NB 9298, p 64 (U...Service: Edgewood Arsenal, MD, 1921, UNCLASSIFIED Report (AD-B955153). Steadman, A. Isolation ofCapsaicin from Capsicum ; EACD 188; U.S. Army Chemical

Image Understanding Architecture Prototype Evaluation and Development

DTIC Science & Technology

1993-06-01

combination of the two. There are examples where a hybrid of these approaches have been used (for example, Cedar [ Gajski 83; 86], NETRA [Sharma 85], and PM4...interconnection network can be found in Cedar [ Gajski 83; Gajski 86], Aquarius [Srini 851, the Las Alamos project [Trujillo 82], and the Burroughs Scientific...Foster 76 1 C. C. Foster, Content Addressable Parallel Processors, Van Nostrand Reinhold Company, New York, 1976. [ Gajski 83 ] Daniel Gajski et al

Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)

PubMed Central

Ullah, Farman; Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Christopher A.; Bi, Danse; Hanson, Paul R.; Organ, Michael G.

2013-01-01

A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition strategy is reported. The optimized protocol in MACOS was utilized for scale-out and further extended for library production using a multicapillary flow reactor. A 50-member library of 1,2,5-thiadiazepane 1,1-dioxides was prepared on a 100- to 300-mg scale with overall yields between 50 and 80% and over 90 % purity determined by proton nuclear magnetic resonance (1H-NMR) spectroscopy. PMID:24244871

Molecular Characterization of Thiols in Fossil Fuels by Michael Addition Reaction Derivatization and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

PubMed

Wang, Meng; Zhao, Suoqi; Liu, Xuxia; Shi, Quan

2016-10-04

Thiols widely occur in sediments and fossil fuels. However, the molecular composition of these compounds is unclear due to the lack of appropriate analytical methods. In this work, a characterization method for thiols in fossil fuels was developed on the basis of Michael addition reaction derivatization followed by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS). Model thiol compound studies showed that thiols were selectively reacted with phenylvinylsulfone and transformed to sulfones with greater than 98% conversions. This method was applied to a coker naphtha, light and heavy gas oils, and crude oils from various geological sources. The results showed that long alkyl chain thiols are readily present in petroleum, which have up to 30 carbon atoms. Large DBE dispersity of thiols indicates that naphthenic and aromatic thiols are also present in the petroleum. This method is capable of detecting thiol compounds in the part per million range by weight. This method allows characterization of thiols in a complex hydrocarbon matrix, which is complementary to the comprehensive analysis of sulfur compounds in fossil fuels.

Black Silicon Germanium (SiGe) for Extended Wavelength Near Infrared Electro-optical Applications

DTIC Science & Technology

2010-05-01

samples were dipped in an aqueous solution of iodine (I) and potassium iodide (KI) (25 gm I and 100 gm KI per liter of water [H2O] ) (16). The samples...Satterfield, C. N.; Wentworth, R. L. in Hydrogen Peroxide , Reinhold Publishing, New York, 1955, p. 370. 12 19. Kishioka, K.; Horita, S.; Ohdaria, K...germanium H2O water HBT heterojunction bipolar transistor I iodine IPA isopropal alcohol KI potassium iodide MEE metal enhanced etching

Effects of Strong Local Sporadic E on ELF Propagation.

DTIC Science & Technology

1978-08-15

Huygens diffraction model (e.g., Marcuse , 1972). The model is similar to that used by Crombie. Unlike Crombie’s work however , the Fresnel approximation...40. Marcuse , D., “Light transmission optics ,” Van Nostrand Reinhold Co., New York , 1972. Papper t , R. A. & Moler , W. F., “A theoretica’ study of...ATTN Donald Dubbert O1 CY ATTN Herbert Rend University of IllinoisDepartment of Electrical Engineering Develco Urbana , IL 61803 530 Logue Avenue O2CY

Aerobic Biodegradation of DI-n-Butylphthalate by Pure and Mixed Bacterial Species

DTIC Science & Technology

1996-05-01

70 days in their studies. Wang and Grady (1995)7 explored the effects of biosorption and dissolution on the biodegradation of DBP. Biosorption ...isotherms for DBP by live and dead bacteria was evaluated by Wang and Grady (1994)4. Biosorption was significant in both live and dead bacteria, however, it...Data on Organic Chemicals. 2nd Ed., Van Nostrand Reinhold Company, New York. 4. Wang, X. and Grady Jr., C. P. L. (1994) Comparison of Biosorption

Annual Progress Report Fiscal Year 1979 (U.S. Army Research Institute of Environmental Medicine, Natick, MA)

DTIC Science & Technology

1979-10-01

J. B. Sampson. A new inventory for the assessment of symptom occurrence and severity at high altitude. Aviat. Space Environ. Med. 50(9)925:929, 1979...Aviat. Space Environ. Med. 47:280-301, 1976. 3. Caridis, D. T., R. B. Reinhold, P. W. Woodruff and J. Fine. Endotoxemia in man. Lancet. 2:1381-1386...Accidental hypothermia: An experimental study of practical rewarming methods. Aviat. Space Environ. Med. 48:625-632, 1977. 4. D’Amato, H. E., S. Kronhein

Induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) by Glycyrrhiza species used for women's health: differential effects of the Michael acceptors isoliquiritigenin and licochalcone A

PubMed Central

Hajirahimkhan, Atieh; Simmler, Charlotte; Dong, Huali; Lantvit, Daniel D.; Li, Guannan; Chen, Shao-Nong; Nikolić, Dejan; Pauli, Guido F.; van Breemen, Richard B.; Dietz, Birgit M.; Bolton, Judy L.

2016-01-01

For the alleviation of menopausal symptoms, women frequently turn to botanical dietary supplements, such as licorice and hops. In addition to estrogenic properties, these botanicals could also have chemopreventive effects. We have previously shown that hops and its Michael acceptor xanthohumol (XH) induced the chemoprevention enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), in vitro and in vivo. Licorice species could also induce NQO1, as they contain the Michael acceptors isoliquiritigenin (LigC) found in Glycyrrhiza glabra (GG), G. uralensis (GU), and G. inflata (GI) and licochalcone A (LicA) which is only found in GI. These licorice species and hops induced NQO1 activity in murine hepatoma (Hepa1c1c7) cells; hops >> GI > GG ≅ GU. Similar to the known chemopreventive compounds curcumin (turmeric), sulforaphane (broccoli), and XH, LigC and LicA were active dose-dependently; sulforaphane >> XH > LigC > LicA ≅ curcumin >> LigF. Induction of the antioxidant response element-luciferase in human hepatoma (Hep-G2-ARE-C8) cells suggested involvement of the Keap1-Nrf2 pathway. GG, GU, and LigC also induced NQO1 in non-tumorigenic breast epithelial MCF-10A cells. In female Sprague-Dawley rats treated with GG and GU, LigC and LigF were detected in the liver and mammary gland. GG weakly enhanced NQO1 activity in the mammary tissue but not in the liver. Treatment with LigC alone did not induce NQO1 in vivo most likely due to its conversion to LigF, extensive metabolism, and its low bioavailability in vivo. These data show the chemopreventive potential of licorice species in vitro could be due to LigC and LicA and emphasize the importance of chemical and biological standardization of botanicals used as dietary supplements. Although the in vivo effects in the rat model after four day treatment are minimal, it must be emphasized that menopausal women take these supplements for extended periods of time and long-term beneficial effects are quite possible. PMID:26473469

A Direct-Learning Approach to Acquiring a Bimanual Tapping Skill.

PubMed

Michaels, Claire F; Gomes, Thábata V B; Benda, Rodolfo N

2017-01-01

The theory of direct learning (D. M. Jacobs & C. F. Michaels, 2007 ) has proven useful in understanding improvement in perception and exploratory action. Here the authors assess its usefulness for understanding the learning of a motor skill, bimanual tapping at a difficult phase relation. Twenty participants attempted to learn to tap with 2 index fingers at 2 Hz with a phase lag of 90° (i.e., with a right-right period of 500 ms and a right-left period of 125 ms). There were 30 trials, each with 50 tapping cycles. Computer-screen feedback informed of errors in both period and phase for each pair of taps. Participants differed dramatically in their success. Learning was assessed by identifying the succession of attractors capturing tapping over the experiment. A few participants' attractors migrated from antiphase to 90° with an appropriate period; others became attracted to a fixed right-left interval, rather than phase, with or without attraction to period. Changes in attractor loci were explained with mixed success by direct learning, inviting elaboration of the theory. The transition to interval attractors was understood as a change in intention, and was remarkable for its indifference to typical bimanual interactions.

More than Words: Comics as a Means of Teaching Multiple Literacies

ERIC Educational Resources Information Center

Jacobs, Dale

2007-01-01

Historically, comics have been viewed as a "debased or simplified word-based literacy," explains Dale Jacobs, who considers comics to be complex, multimodal texts. Examining Ted Naifeh's "Polly and the Pirates," Jacobs shows how comics can engage students in multiple literacies, furthering meaning-making practices in the classroom and beyond.

Reaction Mechanism of Organocatalytic Michael Addition of Nitromethane to Cinnamaldehyde: A Case Study on Catalyst Regeneration and Solvent Effects.

PubMed

Świderek, Katarzyna; Nödling, Alexander R; Tsai, Yu-Hsuan; Luk, Louis Y P; Moliner, Vicent

2018-01-11

The Michael addition of nitromethane to cinnamaldehyde has been computationally studied in the absence of a catalyst and the presence of a biotinylated secondary amine by a combined computational and experimental approach. The calculations were performed at the density functional theory (DFT) level with the M06-2X hybrid functional, and a polarizable continuum model has been employed to mimic the effect of two different solvents: dichloromethane (DCM) and water. Contrary to common assumption, the product-derived iminium intermediate was absent in both of the solvents tested. Instead, hydrating the C1-C2 double bond in the enamine intermediate directly yields the tetrahedral intermediate, which is key for forming the product and regenerating the catalyst. Enamine hydration is concerted and found to be rate-limiting in DCM but segregated into two non-rate-limiting steps when the solvent is replaced with water. However, further analysis revealed that the use of water as solvent also raises the energy barriers for other chemical steps, particularly the critical step of C-C bond formation between the iminium intermediate and nucleophile; this consequently lowers both the reaction yield and enantioselectivity of this LUMO-lowering reaction, as experimentally detected. These findings provide a logical explanation to why water often enhances organocatalysis when used as an additive but hampers the reaction progress when employed as a solvent.

Reaction Mechanism of Organocatalytic Michael Addition of Nitromethane to Cinnamaldehyde: A Case Study on Catalyst Regeneration and Solvent Effects

PubMed Central

2017-01-01

The Michael addition of nitromethane to cinnamaldehyde has been computationally studied in the absence of a catalyst and the presence of a biotinylated secondary amine by a combined computational and experimental approach. The calculations were performed at the density functional theory (DFT) level with the M06-2X hybrid functional, and a polarizable continuum model has been employed to mimic the effect of two different solvents: dichloromethane (DCM) and water. Contrary to common assumption, the product-derived iminium intermediate was absent in both of the solvents tested. Instead, hydrating the C1–C2 double bond in the enamine intermediate directly yields the tetrahedral intermediate, which is key for forming the product and regenerating the catalyst. Enamine hydration is concerted and found to be rate-limiting in DCM but segregated into two non-rate-limiting steps when the solvent is replaced with water. However, further analysis revealed that the use of water as solvent also raises the energy barriers for other chemical steps, particularly the critical step of C–C bond formation between the iminium intermediate and nucleophile; this consequently lowers both the reaction yield and enantioselectivity of this LUMO-lowering reaction, as experimentally detected. These findings provide a logical explanation to why water often enhances organocatalysis when used as an additive but hampers the reaction progress when employed as a solvent. PMID:29256614

Development and Use of Fluorescent Probes for Detection, Enumeration and Identification of Naturally-Occurring Marine Viruses.

DTIC Science & Technology

1992-05-31

Samples were preserved (27) stemmed from a loss in titer that occurred when viruses in 1% glutaraldehyde before application to carbon-coated were added to...counting a minimum of 100 VLPs from 5 random fields at a magnification of 10,000 x. For most applications counting a minimum of 20 fields containing at...biological applications , Vol. 4, Hayat, M.A., editor, Van Nostrom Reinhold, N.Y., 1974, pp 79-104. 15. Proctor, L.M., and Fuhrman, J.A., Viral mortality

Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines.

PubMed

Soloshonok, Vadim A; Ueki, Hisanori; Tiwari, Rohit; Cai, Chaozhong; Hruby, Victor J

2004-07-23

This study demonstrates a new strategy for controlling the stereochemical outcome of the Michael addition reactions between nucleophilic glycine equivalents and alpha,beta-unsaturated carboxylic acid derivatives: The addition reactions between achiral Ni(II)-complex of the Schiff base of glycine with o-[N-alpha-pycolylamino]acetophenone and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones were shown to occur at room temperature in the presence of nonchelating organic bases and, most notably, with very high stereoselectivity at both newly formed stereogenic centers. Thus, the chiral 4-phenyl-1,3-oxazolidin-2-one moiety was found to control efficiently both face diastereoselectivities of the glycine derived enolate and the C,C double bond of the Michael acceptor. The new strategy developed in this work is methodologically superior to previous methods, most notably in terms of generality and synthetic efficiency. Excellent chemical yields and diastereoselectivities, combined with the simplicity of the experimental procedures, render the present method of immediate use for preparing various 3-substituted pyroglutamic acids and related amino acids (glutamic acids, glutamines, prolines, etc.) available via conventional transformations of the former.

X-24B with Test Pilot Michael V. Love

NASA Technical Reports Server (NTRS)

1973-01-01

This photo shows Air Force Lieutenant Colonel Michael V. Love in front of the X-24B lifting-body research vehicle at Edwards Air Force Base in 1973. Love was assigned as a project pilot on the joint NASA-USAF X-24B Lifting Body flight test program at the NASA Flight Research Center. He made a total of 12 flights in the plane from October 4, 1973 until July 15, 1975. Love flew it to a speed of Mach 1.76 on October 25, 1974, a record for the X-24B. Love attended the USAF Test Pilot School and remained as an instructor there from 1969 through 1971. He was a test pilot at Edwards when assigned to fly to the X-24B. Love was a combat veteran of Vietnam and was awarded the Distinguished Flying Cross with two Oak Leaf clusters. Love perished while attempting an emergency landing in an RF-4C on March 1, 1976. The X-24B was the last aircraft to fly in the Dryden Flight Research Center's manned lifting body program. The X-24 was one of a group of lifting bodies flown by the NASA Flight Research Center (now Dryden Flight Research Center), Edwards, California, in a joint program with the U.S. Air Force at Edwards Air Force Base from 1963 to 1975. The lifting bodies were used to demonstrate the ability of pilots to maneuver and safely land wingless vehicles designed to fly back to Earth from space and be landed like an airplane at a predetermined site. Lifting bodies' aerodynamic lift, essential to flight in the atmosphere, was obtained from their shape. The addition of fins and control surfaces allowed the pilots to stabilize and control the vehicles and regulate their flight paths. Built by Martin Aircraft Company, Maryland, for the U.S. Air Force, the X-24A was a bulbous vehicle shaped like a teardrop with three vertical fins at the rear for directional control. It weighed 6,270 pounds, was 24.5 feet long and 11.5 feet wide (measuring just the fuselage, not the distance between the tips of the outboard fins). Its first unpowered glide flight was on April 17, 1969, with Air

The Ballet of the Streets: Teaching about Cities at Street Level

ERIC Educational Resources Information Center

McGuire, Patrick A.; Spates, James L.

2011-01-01

The urban scholar Jane Jacobs once described city life as "the ballet of the streets." In more than a quarter century of joint teaching, the authors have used Jacobs' metaphor to help their students understand that cities are living organisms created and maintained, for good or ill, by the people who live and work in them. At heart their…

The Recycling Solution: How I Increased Recycling on Dilworth Road

ERIC Educational Resources Information Center

Keller, J. Jacob

2010-01-01

The grandson of Fred Keller, one of the founders of behavior analysis, Jacob was 10 years old when he conducted the project for his elementary school science fair. We recently contacted Jacob to learn more about his project. He told us the inspiration came from a class field trip to the county recycling center, which included seeing video footage…

Computational Study of the Aza-Michael Addition of the Flavonoid (+)-Taxifolin in the Inhibition of β-Amyloid Fibril Aggregation.

PubMed

Ginex, Tiziana; Trius, Marta; Luque, F Javier

2018-04-17

Inhibition of abnormal protein self-aggregation is an attractive strategy against amyloidogenic diseases, but has found limited success due to the complexity of protein self-assembly, the absence of fully reproducible aggregation assays, and the scarce knowledge of the inhibition mechanisms by small molecules. In this context, catechol-containing compounds may lead to covalent adducts with amyloid fibrils that interfere with the aggregation process. In particular, the covalent adduct formed between the oxidized form of (+)-taxifolin and an β-amyloid (Aβ42) suggests the involvement of a specific recognition motif that enables the chemical reaction with Aβ42. In this study, we have examined the mechanisms implicated in the aza-Michael addition of the o-quinone species of (+)-taxifolin with Aβ42 fibrils. The results support the binding of (+)-taxifolin to the hydrophobic groove delimited by the edges defined by Lys16 and Glu22 residues in the fibril. The chemical reaction proceeds through the nucleophilic attack of the deprotonated amino group of a Lys16 residue in a process activated by the interaction between the o-quinone ring with a vicinal Lys16 residue, as well as by a water-assisted proton transfer, which is the rate-limiting step of the reaction. This specific inhibition mechanism, which may explain the enhanced anti-aggregating activity of oxidized flavonoids compared to fresh compounds, holds promise for developing disease-modifying therapies. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

29 CFR 1915.74 - Access to vessels.

Code of Federal Regulations, 2011 CFR

2011-07-01

... rigged at the foot of the gangway in such a manner as to prevent employees from falling from the end of the gangway. (7) If the foot of the gangway is more than one foot away from the edge of the apron, the... this section. (d) Jacob's ladders. (1) Jacob's ladders shall be of the double rung or flat tread type...

KSC-2013-1097

NASA Image and Video Library

2013-01-17

CAPE CANAVERAL, Fla. - At NASA's Kennedy Space Center in Florida, Jacobs Technology General Manager Andy Allen speaks at a town hall meeting providing attendees an opportunity to learn about the Test and Operations Support Contract, or TOSC, hiring process and to introduce the organization's management team. NASA recently awarded its TOSC contract to Jacobs Technology Inc. of Tullahoma, Tenn. Jacobs will provide overall management and implementation of ground systems capabilities, flight hardware processing and launch operations at Kennedy. These tasks will support the International Space Station, Ground Systems Development and Operations, and the Space Launch System, Orion Multi-Purpose Crew Vehicle and Launch Services programs. For more information, visit http://www.nasa.gov/centers/kennedy/news/tosc_awarded.html Photo credit: NASA/Dimitri Gerondidakis

KSC-2013-1098

NASA Image and Video Library

2013-01-17

CAPE CANAVERAL, Fla. - At NASA's Kennedy Space Center in Florida, Jacobs Technology Deputy General Manager Lorna Kenna speaks at a town hall meeting providing attendees an opportunity to learn about the Test and Operations Support Contract, or TOSC, hiring process and to introduce the organization's management team. NASA recently awarded its TOSC contract to Jacobs Technology Inc. of Tullahoma, Tenn. Jacobs will provide overall management and implementation of ground systems capabilities, flight hardware processing and launch operations at Kennedy. These tasks will support the International Space Station, Ground Systems Development and Operations, and the Space Launch System, Orion Multi-Purpose Crew Vehicle and Launch Services programs. For more information, visit http://www.nasa.gov/centers/kennedy/news/tosc_awarded.html Photo credit: NASA/Dimitri Gerondidakis

A late quaternary record of eolian silt deposition in a maar lake, St. Michael Island, western Alaska

USGS Publications Warehouse

Muhs, D.R.; Ager, T.A.; Been, J.; Bradbury, J.P.; Dean, W.E.

2003-01-01

Recent stratigraphic studies in central Alaska have yielded the unexpected finding that there is little evidence for full-glacial (late Wisconsin) loess deposition. Because the loess record of western Alaska is poorly exposed and not well known, we analyzed a core from Zagoskin Lake, a maar lake on St. Michael Island, to determine if a full-glacial eolian record could be found in that region. Particle size and geochemical data indicate that the mineral fraction of the lake sediments is not derived from the local basalt and is probably eolian. Silt deposition took place from at least the latter part of the mid-Wisconsin interstadial period through the Holocene, based on radiocarbon dating. Based on the locations of likely loess sources, eolian silt in western Alaska was probably deflated by northeasterly winds from glaciofluvial sediments. If last-glacial winds that deposited loess were indeed from the northeast, this reconstruction is in conflict with a model-derived reconstruction of paleowinds in Alaska. Mass accumulation rates in Zagoskin Lake were higher during the Pleistocene than during the Holocene. In addition, more eolian sediment is recorded in the lake sediments than as loess on the adjacent landscape. The thinner loess record on land may be due to the sparse, herb tundra vegetation that dominated the landscape in full-glacial time. Herb tundra would have been an inefficient loess trap compared to forest or even shrub tundra due to its low roughness height. The lack of abundant, full-glacial, eolian silt deposition in the loess stratigraphic record of central Alaska may be due, therefore, to a mimimal ability of the landscape to trap loess, rather than a lack of available eolian sediment. ?? 2003 University of Washington. Published by Elsevier Inc. All rights reserved.

Tinkering: a conceptual and historical evaluation.

PubMed

Laubichler, Manfred D

2007-01-01

Francois Jacob's article 'Evolution and Tinkering' published in Science in 1977 is still the locus classicus for the concept of tinkering in biology. It first introduced the notion of tinkering to a wide audience of scientists. Jacob drew on a variety of different sources ranging from molecular biology to evolutionary biology and cultural anthropology. The notion of tinkering, or more accurately, the concept of bricolage, are conceptual abstractions that allow for the theoretical analysis of a wide range of phenomena that are united by a shared underlying process--tinkering, or the opportunistic rearrangement and recombination of existing elements. This paper looks at Jacob's analysis as itself an example of conceptual tinkering. It traces the history of some of its elements and sketches how it has become part of an inclusive discourse of theoretical biology and evolutionary developmental biology that emerged over the last 30 years. I will argue that the theoretical power of Jacob's analysis lies in the fact that he captured a widespread phenomenon. His conceptual analysis is thus an example of an interdisciplinary synthesis that is based on a shared process rather than a shared object.

Thiol-ene Michael-type formation of gelatin/poly(ethylene glycol) biomatrices for three-dimensional mesenchymal stromal/stem cell administration to cutaneous wounds

PubMed Central

Xu, Kedi; Cantu, David Antonio; Fu, Yao; Kim, Jaehyup; Zheng, Xiaoxiang; Hematti, Peiman; Kao, W. John

2013-01-01

Mesenchymal stromal/stem cells (MSCs) are considered promising cellular therapeutics in the fields of tissue engineering and regenerative medicine. MSCs secrete high concentrations of immunomodulatory cytokines and growth factors, which exert paracrine effects on infiltrating immune and resident cells of the wound microenvironment that could favorably promote healing after acute injury. However, better spatial delivery and improved retention at the site of injury are two factors that could improve the clinical application of MSCs. In this study, we utilized thiol-ene Michael-type addition for rapid encapsulation of MSCs within a gelatin/poly(ethylene glycol) biomatrix; this biomatrix was also applied as a provisional dressing to full-thickness wounds in Sprague-Dawley rats. The three-way interaction of MSCs, gelatin/poly(ethylene glycol) biomatrices, and host immune cells and adjacent resident cells of the wound microenvironment favorably modulated wound progression and host response. In this model we observed attenuated immune cell infiltration, lack of foreign giant cell (FBGC) formation, accelerated wound closure and re-epithelialization, as well as enhanced neovascularization and granulation tissue formation by 7 days. The MSC-entrapped gelatin/poly(ethylene glycol) biomatrix localized the presentation of MSCs adjacent to the wound microenvironment and thus, mediated early resolution of inflammatory events and facilitated proliferative phases in wound healing. PMID:23811217

Analysis of C-17 Departure Reliability and Maintenance Metrics

DTIC Science & Technology

2010-06-01

Washington DC: AFDPO. Anderson, D. R., Sweeney, D. J ., & Williams, T. A . (2008). Statisitcs for Business and Economics. Mason: South-Western...Cengage Learning. Capehart, S. R. (2010, January 21). Major Vincent M Jacobs GRP. (V. M. Jacobs, Interviewer) Coyle, J . C., Bardi , E. J ., & Novack, R...Background Maintenance management metrics—sometimes called quality performance measures or indicators—are a crucial form of information used by

A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson's Research.

PubMed

Baptista, Marco A S; Dave, Kuldip D; Sheth, Niketa P; De Silva, Shehan N; Carlson, Kirsten M; Aziz, Yasmin N; Fiske, Brian K; Sherer, Todd B; Frasier, Mark A

2013-11-01

Progress in Parkinson's disease (PD) research and therapeutic development is hindered by many challenges, including a need for robust preclinical animal models. Limited availability of these tools is due to technical hurdles, patent issues, licensing restrictions and the high costs associated with generating and distributing these animal models. Furthermore, the lack of standardization of phenotypic characterization and use of varying methodologies has made it difficult to compare outcome measures across laboratories. In response, The Michael J. Fox Foundation for Parkinson's Research (MJFF) is directly sponsoring the generation, characterization and distribution of preclinical rodent models, enabling increased access to these crucial tools in order to accelerate PD research. To date, MJFF has initiated and funded the generation of 30 different models, which include transgenic or knockout models of PD-relevant genes such as Park1 (also known as Park4 and SNCA), Park8 (LRRK2), Park7 (DJ-1), Park6 (PINK1), Park2 (Parkin), VPS35, EiF4G1 and GBA. The phenotypic characterization of these animals is performed in a uniform and streamlined manner at independent contract research organizations. Finally, MJFF created a central repository at The Jackson Laboratory (JAX) that houses both non-MJFF and MJFF-generated preclinical animal models. Funding from MJFF, which subsidizes the costs involved in transfer, rederivation and colony expansion, has directly resulted in over 2500 rodents being distributed to the PD community for research use.

Effect of Being an Aviator on Promotion to O-5 in the USMC

DTIC Science & Technology

2011-03-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited EFFECT OF BEING AN...AVIATOR ON PROMOTION TO O-5 IN THE USMC by Jacob L. Reynolds March 2011 Thesis Advisor: Yu-Chu Shen Second Reader: Stephen L. Mehay...Master’s Thesis 4. TITLE AND SUBTITLE Effect of Being an Aviator on Promotion Probability to O-5 in the USMC 6. AUTHOR(S) Jacob L. Reynolds 5

Species-Specific Immunodetection of an Entamoeba histolytica Cyst Wall Protein

PubMed Central

Kearney, Moira R.; Siddique, Abdullah; Ali, Ibne K.; Gilchrist, Carol A.; Arju, Tuhinur; Hoffstrom, Benjamin; Nguyen, Felicia K.; Petri, William A.; Haque, Rashidul; Cangelosi, Gerard A.

2016-01-01

Entamoeba histolytica causes intestinal disease in endemic settings throughout the world. Diagnosis of E. histolytica infection would be improved by the identification of biomarkers that are expressed by cysts of E. histolytica, but not by cysts of closely related commensal species of Entamoeba. Herein, we describe two novel monoclonal antibodies (1A4 and 1D3) produced against a spacer region of the E. histolytica Jacob2 lectin, an outer cyst wall protein. These reagents demonstrated no cross-reaction to E. dispar recombinant antigen and low picomolar molecular detection limits when paired in ELISA sandwich assays. In an immunofluorescence microscopy assay, the α-Jacob2 murine antibodies labeled cysts of three xenically cultured E. histolytica isolates but did not label cysts of three E. bangladeshi isolates. Monoclonal antibody 1A4 did not cross-react with xenic cultures of three E. dispar isolates, demonstrating specificity to E. histolytica, while monoclonal antibody 1D3 cross-reacted with two out of three E. dispar isolates. Both antibodies labeled cysts in formalin-fixed slides, a potential logistical advantage in some settings. The monoclonal antibody 1A4 was also used in an immunofluorescence microscopy assay with formalin-fixed stool specimens. Seven out of ten ELISA-positive stool specimens exhibited 1A4-labeled cyst-like objects, compared to one out of seven ELISA-negative specimens. These results demonstrate that antibodies generated against the flexible spacer of E. histolytica Jacob2 lectin recognize and bind to Jacob2 protein in whole cysts and are capable of differentiating Entamoeba species in fixed specimens. Thus, Jacob2 is a promising biomarker for use in diagnosing E. histolytica infection. PMID:27152855

Center for Advanced Sensors Year Two Funding (FY2006)

DTIC Science & Technology

2008-02-26

Cheong, and F. Zhao (2005) "Semantics-Based Optimization Across Uncoordinated Tasks in Networked Embedded Systems," Proceedings of the 5th ACM Conference...analysis," Optical Engineering, vol. 46, 116401, 2007. R.L. Espinola, E.L. Jacobs, C.E. Halford, D.H. Tofsted and R. Vollmerhausen, "Modeling...the target acquisition performance of active imaging systems," Optics Express, vol. 15, March, 2007. C.E. Halford, A.L. Robinson, E.L. Jacobs and

Analysis of Image Smear in CRT Displays Due to Scan Rate and Phosphor Persistence

DTIC Science & Technology

1982-10-01

Clarence E. Rash 0Sensory Research Division and D. Jacob Becher DTIC Old Dominion University ELECTE Norfolk, Virginia MAY 0 11990 October 1982 U.S...RATE AND PHOSPHOR PERSISTENCE 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) 8. CONTRACT OR GRANT NUMBER(85 Clarence E. Rash Jacob Becher 9. PERFORMING...cathodoluminescence occurs in two stages, fluorescence and phosphorescence. These two stages are distinct because of the timing of the emission of the radiation

Radiation Measurements in Simulated Ablation Layers

DTIC Science & Technology

2010-12-06

J.Spacecraft & Rockets, V35, No 6, 1998, pp 729-735. D‟Souza MG, Eichmann TN, Mudford NR, Potter DF, Morgan RG, McIntyre TJ, Jacobs PA (2009...gases. D. Phil Thesis. Oxford University 1976 Potter, D., Eichmann , T., Brandis, A., Morgan, R., Jacobs, P., McIntyre, T., “Simulation of radiating...Heatshield Material. 46th AIAA Aerospace Sciences Meeting and Exhibit, AIAA2008-1202, Reno, USA. D‟Souza, M.G., Eichmann , T.N., Mudford, N.R., Potter

The Behavior of the Atmosphere in the Desert Planetary Boundary Layer.

DTIC Science & Technology

1983-06-30

i5962 THE BEHAVIOR OF THE ATMOSPHERE IN THE DESERT PL NET RY 1/i. BOUNDARY LAVERMU BEN-GURION UNIV OF THE NEGEV SEDE BOGER (ISRAEL) JACOB BLAUST...DESERT PLANETARY BOUNDARY LAYER Louis Berkofsky The Jacob Blaustein Institute for Desert Research Ben-Gurion University of the Negev Sede Boqer Campus...TASK- nm insl1tute for esert Research AREA A WORK UNiT NUMBERS Ben-Gurion University of the Negev Sede Boqer Campus 84990, Israel F- 3 / St

Vibrationally Excited Ions: Quenching Reaction Enhancement, Lifetimes

DTIC Science & Technology

1991-01-01

affinities in our lad- A,.=Af exp( - AS/IR) = I .IX 10𔄃 cm’ S_ with limits der . Any change it. P.A.(Br), ither due to a change in bet~een 7.Sx l3 9and...8217K P Huber and G Hereberg. C oeto of Drateooc Molecules ( Van "M Tubs’, G JasAay. N D Toeddy. and B. B. Fergusn. Ini J Mass Nostrand-Reinhold. New York...objectives and it seemed possible .aat neut - rals such as N,. Xe and CF, might provide suitable monitor gases for vibra- tionally excited HBr*. For HBr

The Impact of the Degree of Aquifer Confinement and Anisotropy on Tidal Pulse Propagation.

PubMed

Shuai, Pin; Knappett, Peter S K; Hossain, Saddam; Hosain, Alamgir; Rhodes, Kimberly; Ahmed, Kazi Matin; Cardenas, M Bayani

2017-07-01

Oceanic tidal fluctuations which propagate long distances up coastal rivers can be exploited to constrain hydraulic properties of riverbank aquifers. These estimates, however, may be sensitive to degree of aquifer confinement and aquifer anisotropy. We analyzed the hydraulic properties of a tidally influenced aquifer along the Meghna River in Bangladesh using: (1) slug tests combined with drilling logs and surface resistivity to estimate Transmissivity (T); (2) a pumping test to estimate T and Storativity (S) and thus Aquifer Diffusivity (D PT ); and (3) the observed reduction in the amplitude and velocity of a tidal pulse to calculate D using the Jacob-Ferris analytical solution. Average Hydraulic Conductivity (K) and T estimated with slug tests and borehole lithology were 27.3 m/d and 564 m 2 /d, respectively. Values of T and S determined from the pumping test ranged from 400 to 500 m 2 /d and 1 to 5 × 10 -4 , respectively with D PT ranging from 9 to 40 × 10 5  m 2 /d. In contrast, D estimated from the Jacob-Ferris model ranged from 0.5 to 9 × 10 4  m 2 /d. We hypothesized this error resulted from deviations of the real aquifer conditions from those assumed by the Jacob-Ferris model. Using a 2D numerical model tidal pulses were simulated across a range of conditions and D was calculated with the Jacob-Ferris model. Moderately confined (K top /K aquifer  < 0.01) or anisotropic aquifers (K x /K z  > 10) yield D within a factor of 2 of the actual value. The order of magnitude difference in D between pumping test and Jacob-Ferris model at our site argues for little confinement or anisotropy. © 2017, National Ground Water Association.

The challenges of staffing urban schools with effective teachers.

PubMed

Jacob, Brian A

2007-01-01

Brian Jacob examines challenges faced by urban districts in staffing their schools with effective teachers. He emphasizes that the problem is far from uniform. Teacher shortages are more severe in certain subjects and grades than others, and differ dramatically from one school to another. The Chicago public schools, for example, regularly receive roughly ten applicants for each teaching position. But many applicants are interested in specific schools, and district officials struggle to find candidates for highly impoverished schools. Urban districts' difficulty in attracting and hiring teachers, says Jacob, means that urban teachers are less highly qualified than their suburban counterparts with respect to characteristics such as experience, educational background, and teaching certification. But they may not thus be less effective teachers. Jacob cites recent studies that have found that many teacher characteristics bear surprisingly little relationship to student outcomes. Policies to enhance teacher quality must thus be evaluated in terms of their effect on student achievement, not in terms of conventional teacher characteristics. Jacob then discusses how supply and demand contribute to urban teacher shortages. Supply factors involve wages, working conditions, and geographic proximity between teacher candidates and schools. Urban districts have tried various strategies to increase the supply of teacher candidates (including salary increases and targeted bonuses) and to improve retention rates (including mentoring programs). But there is little rigorous research evidence on the effectiveness of these strategies. Demand also has a role in urban teacher shortages. Administrators in urban schools may not recognize or value high-quality teachers. Human resource departments restrict district officials from making job offers until late in the hiring season, after many candidates have accepted positions elsewhere. Jacob argues that urban districts must improve hiring

X-24B with Test Pilot Lt. Col. Michael V. Love

NASA Technical Reports Server (NTRS)

1976-01-01

This photo shows Air Force Lieutenant Colonel Michael V. Love in front of the X-24B lifting body research vehicle at Edwards Air Force Base in 1976. Love was assigned as a project pilot on the joint NASA-USAF X-24B Lifting Body flight test program at the NASA Flight Research Center. He made a total of 12 flights in the plane from October 4, 1973 until July 15, 1975. Love flew it to a speed of Mach 1.76 on October 25, 1974, a record for the X-24B. Love attended the USAF Test Pilot School and remained as an instructor there from 1969 through 1971. He was a test pilot at Edwards when assigned to fly to the X-24B. Love was a combat veteran of Vietnam and was awarded the Distinguished Flying Cross with two Oak Leaf clusters. Love perished while attempting an emergency landing in an RF-4C on March 1, 1976 - less than a month after this photo was taken. The X-24B was the last aircraft to fly in the Dryden Flight Research Center's manned lifting body program. The X-24 was one of a group of lifting bodies flown by the NASA Flight Research Center (now Dryden Flight Research Center), Edwards, California, in a joint program with the U.S. Air Force at Edwards Air Force Base from 1963 to 1975. The lifting bodies were used to demonstrate the ability of pilots to maneuver and safely land wingless vehicles designed to fly back to Earth from space and be landed like an airplane at a predetermined site. Lifting bodies' aerodynamic lift, essential to flight in the atmosphere, was obtained from their shape. The addition of fins and control surfaces allowed the pilots to stabilize and control the vehicles and regulate their flight paths. Built by Martin Aircraft Company, Maryland, for the U.S. Air Force, the X-24A was a bulbous vehicle shaped like a teardrop with three vertical fins at the rear for directional control. It weighed 6,270 pounds, was 24.5 feet long and 11.5 feet wide (measuring just the fuselage, not the distance between the tips of the outboard fins). Its first unpowered

1001619

NASA Image and Video Library

2010-09-15

SAMUEL SMITH (WELD TECHNICIAN, JACOBS ESTS GROUP/ALL POINTS) AND ANDRÉ PASEUR (WELD TECHNICIAN, JACOBS ESTS GROUP/ERC) DISPLAY TWO PROCESS DEMONSTRATION ARTICLES – A 9-FOOT BUTT WELD (FOREGROUND) AND A HEXAGON FABRICATED FROM FRICTION STIR WELDED PLATES (BACKGROUND) – THAT WERE FABRICATED FROM 6AL-4V TITANIUM (ELI) USING THERMAL STIR WELDING. THIS WORK WAS PERFORMED FOR A NASA TECHNOLOGY TRANSFER INDUSTRIAL PARTNER (KEYSTONE SYNERGETIC ENTERPRISES, INC.) IN SUPPORT OF A PROJECT FOR THE U.S. NAVY

Lessons from U.S. Allies in Security Cooperation with Third Countries: The Cases of Australia, France, and the United Kingdom

DTIC Science & Technology

2011-01-01

Force 2030, Defence White Paper 2009, May 2, 2009c. b Commission du Livre blanc, Défense et Sécurité Nationale: Le Livre Blanc, Paris : Odile Jacob...Australia, France, the UK, and the United States. However, unless an exercise was part of the original training package, many times those skills are not...May 2, 2009c; Commission du Livre blanc, Défense et Sécurité Nationale: Le Livre Blanc, Paris : Odile Jacob/La Documentation Française, June 2008

Michael Seibert | NREL

Science.gov Websites

Artificial Photosynthesis for H2Production, April 22-23, 2003, sponsored by the Air Force Office of Scientific Research. Member, US-Australian Working Group on Artificial Photosynthesis, August 2002-2003

Michael Woodhouse | NREL

Science.gov Websites

, physics and chemistry. (1998-2002) Featured Publications Fu, R., T.L. James, M. Woodhouse. "Economic /10.1039/C3EE40701B. Goodrich, A., P. Hacke, Q. Wang, B. Sopori, R. Margolis, T.L. James, and Woodhouse, M InformationMicrosoft Excel. Woodhouse, M., A. Goodrich, R. Margolis, T.L. James, M. Lokanc, and R. Eggert. "

Michael Deru | NREL

Science.gov Websites

development and testing of novel HVAC systems, building performance simulations, performance metrics for | 303-384-7503 Dr. Deru joined NREL in 2000 and manages the Systems Performance section in the

Michael Bahl | NREL

Science.gov Websites

theoretical mathematics, Western New England University, Springfield, MA B.S. in computer science, University Prior Work Experience Founder, Mobile Makes Sense Senior IT Specialist, IBM Graduate Teaching Assistant

Michael Sprague | NREL

Science.gov Websites

student, he developed a parallel spectral finite element method for treating the interaction of large mechanics of fluids, structures, and their interaction|Spectral finite-element methods for time-dependent

Michael Deceglie | NREL

Science.gov Websites

postdoctoral researcher focused on photovoltaic performance and reliability. His current research interests illumination nonuniformity, and outdoor performance of advanced photovoltaic technologies. Featured photovoltaic module," Proceedings of the Thirty-ninth IEEE Photovoltaic Specialists Conference (PVSC), pp

Michael Griffin | NREL

Science.gov Websites

production of high-value products Physical and chemical material characterization under reaction conditions Heterogeneous catalysis Design and operation of reactor systems Analysis of reaction kinetics and mechanisms labeled "major reaction products" at the top. On the right is a figure of blue spheres with a

Michael Resch | NREL

Science.gov Websites

producing ammonia. The outcome of this project will be to make ammonia synthesis more sustainable and ) without affecting the ammonia production rate. Such an ammonia synthesis is ideally suitable for small-scale ammonia synthesis system using water and air, powered by wind energy. Instead of developing

Developing the Parachute System for NASA's Orion: An Overview at Inception

NASA Technical Reports Server (NTRS)

Machin, Ricardo; Taylor, Anthony P.; Royall, Paul

2007-01-01

As the Crew Exploration Vehicle (CEV) program developed, NASA decided to provide the parachute portion of the landing system as Government Furnished Equipment (GFE) and designated NASA Johnson Space Center (JSC) as the responsible NASA center based on JSC s past experience with the X-38 program. JSC subsequently chose to have the Engineering Support contractor Jacobs Sverdrup to manage the overall program development. After a detailed source selection process Jacobs chose Irvin Aerospace Inc (Irvin) to provide the parachutes and mortars for the CEV Parachute Assembly System (CPAS). Thus the CPAS development team, including JSC, Jacobs and Irvin has been formed. While development flight testing will have just begun at the time this paper is submitted, a number of significant design decisions relative to the architecture for the manned spacecraft will have been completed. This paper will present an overview of the approach CPAS is taking to providing the parachute system for CEV, including: system requirements, the preliminary design solution, and the planned/completed flight testing.

KSC-2012-2296

NASA Image and Video Library

2012-04-16

CAPE CANAVERAL, Fla. – At the Shuttle Landing Facility at NASA’s Kennedy Space Center in Florida, STS-133 Mission Specialists Nicole Stott and Michael Barratt pose for a photographer in front of a Shuttle Carrier Aircraft on which space shuttle Discovery has been secured for departure. Stott and Barratt were members of the crew to fly on Discovery’s final mission in February and March 2011. Other members of the STS-133 crew were Commander Steve Lindsey, Pilot Eric Boe, and Mission Specialists Alvin Drew and Steve Bowen. Discovery is scheduled to depart from Kennedy for the final time tomorrow morning. Also known as an SCA, the aircraft is a Boeing 747 jet, originally manufactured for commercial use, which was modified by NASA to transport the shuttles between destinations on Earth. The SCA designated NASA 905 is assigned to the remaining ferry missions, delivering the shuttles to their permanent public display sites. NASA 905 is scheduled to ferry Discovery to the Washington Dulles International Airport in Virginia on April 17, after which the shuttle will be placed on display in the Smithsonian's National Air and Space Museum Steven F. Udvar-Hazy Center. For more information on the SCA, visit http://www.nasa.gov/centers/dryden/news/FactSheets/FS-013-DFRC.html. For more information on shuttle transition and retirement activities, visit http://www.nasa.gov/transition. Photo credit: NASA/Tim Jacobs

'Irish & Roman Catholic Which Upsets All the People Here': Michael McDonnell and British Colonial Justice in Mandatory Palestine, 1927-1936.

PubMed

Davis, Simon

2017-10-23

In 1927 Michael McDonnell, a diasporic Irish Catholic, was appointed Mandatory Palestine's Chief Justice, being directed to institute firm British-style legal-judicial foundations for future self-governance. This entailed common, equal status for Arab and Jewish Palestinians, implicitly de-privileging the Jewish National Home. McDonnell was resisted in this by the British Mandate's Anglo-Jewish, pro-Zionist Attorney General, Norman Bentwich. McDonnell prevailed but only at the cost of being characterized lastingly as a pro-Arab, Catholic anti-Semite. McDonnell's continuing defence of a supreme, independent judiciary antagonized the Palestine Executive of High Commissioner Arthur Wauchope, who tried to co-opt rather than subordinate Zionist interests. Consequent frictions culminated in 1936 with McDonnell adjudicating against supra-legal British repression of Palestine's great Arab rebellion. For this he was dismissed and ostracized, subsequently publishing critiques of British policy in fringe right-wing organs. Yet McDonnell professed explicitly non-racist views, reflecting a liberal-minded, constitutional Irish nationalist equation of Palestine with Ireland, seeing comparable settler-colonial abuses and native distress as remediable only by transcendentally impartial justice. Britain reneging on these principles led McDonnell, like those Irish imperial servants noted in India, to identify with colonial subjects against colonialism. His case is one of empire as a system of domination being challenged from within, although his removal foreshadowed emerging imperial counter-insurgency's tendency not only to repress subject populations but deny civil-progressive alternatives for managing post-colonial transition. © The Author [2017]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

VizieR Online Data Catalog: Activity cycles in 3203 Kepler stars (Reinhold+, 2017)

NASA Astrophysics Data System (ADS)

Reinhold, T.; Cameron, R. H.; Gizon, L.

2017-05-01

Rvar time series, sine fit parameters, mean rotation periods, and false alarm probabilities of all 3203 Kepler stars are presented. For simplicity, the KIC number and the fit parameters of a certain star are repeated in each line. The fit function to the Rvar(t) time series equals y_fit=Acyc*sin(2*pi/(Pcyc*365)*(t-t0))+Offset. (2 data files).

The Role of Interleukin-6 in Lipopolysaccharide-Induced Weight Loss, Hypoglycemia and Fibrinogen Production, in Vivo

DTIC Science & Technology

1994-07-01

acute inflammation, since direct admin- Research Institute, Bethesda, MD 20614, USA. Address corespondence to: Dr G . Srssmann, Ouka America istration of...ELiSA, Romts e expresd W im x 10-MlO or mGio B-9 Sonay md ELISA. mpeeively. Nomal k-vels of IL.6 in WDFt mice we 0.02 :t 0.01 og&ud in ElISA. Mwe addkiod...pharmaceutical-grade antibody was used (a 6. Strassmann G , Fong M, Kenney JS, Jacob CO (1992) gift from Dr C.O. Jacob, Syntex, Palo Alto, CA). The Evidence for

Corrosion/Deterioration of Fuel Tank Materials Wetted in Methanolic Electrolytes

DTIC Science & Technology

1987-12-15

R32 DD FORM 1473, 84 MAR 83 APR edition may be used until exhausted. SECURITY CLASSIFICATION OF THIS PAGE All other editions are obsolete *U.S... aiSA A12A A1AS5!S1tit "IiaA Id~A1131 *AWFl 1t1103114W) No us" C C A C A C C A~tt A A CS Sell lA~~~l, 5158-lti A ICC :1L1 1113iC AlMeAtt2~ TIttrljACn...Corrosion Resistance of Metals and Alloys, Second Edition , Reinhold Publishing Corporation, NY, 1963, p. 217. 4. Uhlig, H. H., Coroion.and Corrosion

Variability of the proton-to-electron mass ratio on cosmological scales

NASA Astrophysics Data System (ADS)

Wendt, M.; Reimers, D.

2008-10-01

The search for a possible variation of fundamental physical constants isnewsworthy more than ever. A multitude of methods were developed. So far theonly seemingly significant indication of a cosmological variation existsfor the proton-to-electron massratio as stated by Reinhold et al. [1]. The measuredindication of variation is based on the combined analysis of H2 absorptionsystems in the spectra of Q0405-443 and Q0347-383 at zabs=2.595 and zabs=3.025, respectively. The high resolution data of the latteris reanalyzed in this work to examine the influence of different fittingprocedures and further potential nonconformities. This analysis cannotreproduce the significance achieved by the previous works.

System Integration and Interface Transition Issues.

DTIC Science & Technology

1977-04-01

OC - 4- u -O m4 U V L.- I~V 0~ C 0 - i CC 0 .iOC30~i .- ~. C > u uU O! ul Wi 0) i~ LUn CL04) z w 0 CL-0r I.- ~ ~~~~ in0 6 - 2-A 0 ~ 4) 0 zEC u~5. 0...Systems Design and Documentation - An Introduction to the HIPO Method, Van Nostrand Reinhold Co. (1976). [34] Peter Freeman, "Toward Improved Review of...Software Design," Proc. National Computer Conf. 44, AFIPS Press (1975) pp 329-334. [35] Peter G. Neumann, "Software Development & Proofs of Multi-Level

Building the "fable hospital"--the CEO's perspective: an interview with Michael H. Covert, president and chief executive officer, Palomar Pomerado Health. Interview by David A Tam.

PubMed

Covert, Michael

2012-01-01

Hospital construction is a significant event in any health system. The financial implications are great, especially at a time of shrinking capital resources. Personnel are affected, as are the processes to perform their tasks. Often, new facilities are catalysts that change organizational culture; it has been clearly shown that new facilities have a positive impact on patient satisfaction scores. The members of the C-suite of a hospital/health system play important roles in construction projects. However, no one is more critical to the success of such major endeavors than the chief executive officer (CEO). The CEO sets the tone for the project, giving direction to the design and construction process that may have implications for the rest of the organization. Palomar Pomerado Health (PPH) is the largest public health district in California. In 2002, the PPH governing board authorized the creation of a new facility master plan for the district, which included the construction of a replacement facility for its tertiary care trauma center. The new Palomar Medical Center is slated to open in August 2012. HERD had the opportunity to speak with PPH CEO Michael H. Covert on the role of the CEO in the building of this "fable hospital".

Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds.

PubMed

Huang, Guang; Ou, Junjie; Wang, Hongwei; Ji, Yongsheng; Wan, Hao; Zhang, Zhang; Peng, Xiaojun; Zou, Hanfa

2016-04-01

A novel silica-based stationary phase with branched octadecyl groups was prepared by the sequential employment of the Michael addition reaction and photoinduced thiol-yne click chemistry with 3-aminopropyl-functionalized silica microspheres as the initial material. The resulting stationary phase denoted as SiO2 -N(C18)4 was characterized by elemental analysis, FTIR spectroscopy and Raman spectroscopy, demonstrating the existence of branched octadecyl groups in silica microspheres. The separations of benzene homologous compounds, acid compounds and amine analogues were conducted, demonstrating mixed-mode separation mechanism on SiO2 -N(C18)4 . Baseline separation of basic drugs mixture was acquired with the mobile phase of acetonitrile/H2 O (5%, v/v). SiO2 -N(C18)4 was further applied to separate Corydalis yanhusuo Wang water extracts, and more baseline separation peaks were obtained for SiO2 -N(C18)4 than those on Atlantis dC18 column. It can be expected that this new silica-based stationary phase will exhibit great potential in the analysis of basic compounds. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pondering the Printz Award. The Michael L. Printz Award for Excellence in Young Adult Literature; The Making of a Printz; The Truth about Trueman: An Interview with Terry Trueman; "Beautiful"..."Fresh"..."Distinguished" Books: Teen Readers Take on the 2002 Printz Awards; Soap Box: A Young Adult Publisher Speaks Out about Winning the Printz Award; Retro Mock Printz: The Best of the Best of Young Adult Literature from the VOYA Years.

ERIC Educational Resources Information Center

Butts, Peter; Halls, Kelly Milner; Horne, Claire; Roxburgh, Stephen; Cornish, Sarah; Jones, Patrick

2002-01-01

Includes six articles that discuss the Michael L. Printz award for excellence in young adult literature, established by the Young Adult Library Services Association (YALSA) of the American Library Association (ALA). Highlights include a list of winners for the past three years; quality versus popularity; and perspectives from authors, teens, and…

Highly convergent synthesis of chiral bicyclophosphinates by domino hydrophosphinylation/Michael/Michael reaction.

PubMed

Fourgeaud, Pierre; Daydé, Bénédicte; Volle, Jean-Noël; Vors, Jean-Pierre; Van der Lee, Arie; Pirat, Jean-Luc; Virieux, David

2011-10-07

Diastereoselective domino reactions of iminoalcohols and allenyl H-phosphinates produce chiral phosphorus bicycles in a regio- and stereoselective fashion. A predictive model for diastereoselection is used for these new chiral phosphinic esters. © 2011 American Chemical Society

Small scale wind tunnel model investigation of hybrid high lift systems combining upper surface blowing with the internally blown flap

NASA Technical Reports Server (NTRS)

Waites, W. L.; Chin, Y. T.

1974-01-01

A small-scale wind tunnel test of a two engine hybrid model with upper surface blowing on a simulated expandable duct internally blown flap was accomplished in a two phase program. The low wing Phase I model utilized 0.126c radius Jacobs/Hurkamp flaps and 0.337c radius Coanda flaps. The high wing Phase II model was utilized for continued studies on the Jacobs/Hurkamp flap. Principal study areas included: basic data both engines operative and with an engine out, control flap utilization, horizontal tail effectiveness, spoiler effectiveness, USB nacelle deflector study and USB/IBF pressure ratio effects.

77 FR 67020 - Performance Review Board Appointments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

..., Tommy Beck, Richard Belin, Alletta Berrigan, Michael Black, Michael Black, Steven Blanchard, Mary Josie..., Robert Reidenbach, Dennis Reynolds, Michael Rice, Bryan Roberson, Edwin Rountree, Carl Russ, David...

Documentation in a Software Maintenance Environment.

DTIC Science & Technology

1987-08-28

Michael Jackson Diagrams 0...8217 ." " . ." ." ""’, " , "" " - . -’" ,," ’" " " "’" d t Review of Documentation Techniques Michael Jackson Diagrams Michael Jackson diagrams show data...coupling and cohesion. Logic is not represented in this technique, which thus is of limited value. Advantages: Michael Jackson diagrams are similar

Microstructural Parameters in 8 MeV Electron-Irradiated BOMBYX MORI Silk Fibers by Wide-ANGLE X-Ray Scattering Studies (waxs)

NASA Astrophysics Data System (ADS)

Sangappa, Asha, S.; Sanjeev, Ganesh; Subramanya, G.; Parameswara, P.; Somashekar, R.

2010-01-01

The present work looks into the microstructural modification in electron irradiated Bombyx mori P31 silk fibers. The irradiation process was performed in air at room temperature using 8 MeV electron accelerator at different doses: 0, 25, 50 and 100 kGy. Irradiation of polymer is used to cross-link or degrade the desired component or to fix the polymer morphology. The changes in microstructural parameters in these natural polymer fibers have been computed using wide angle X-ray scattering (WAXS) data and employing line profile analysis (LPA) using Fourier transform technique of Warren. Exponential, Lognormal and Reinhold functions for the column length distributions have been used for the determination of crystal size, lattice strain and enthalpy parameters.

Assessing the issue of instability due to Michael adduct formation in novel chemical entities possessing a carbon-carbon double bond during early drug development--applicability of common laboratory analytical protocols.

PubMed

Polepally, Akshanth Reddy; Kumar, Venkata V Pavan; Bhamidipati, Ravikanth; Kota, Jagannath; Naveed, Shaik Abdul; Reddy, Karnati Harinder; Mamidi, Rao N V S; Selvakumar, N; Mullangi, Ramesh; Srinivas, Nuggehally R

2008-09-01

The discovery of small-molecule novel chemical entities (NCEs) is often a complex play between appropriate structural requirements and optimization of the desired efficacy, safety and pharmacokinetic properties. One of the typical structural variants such as having an active carbon-carbon double bond (alpha, beta-unsaturated carbonyl group) in xenobiotics may lead to stability issues. Such functionalities are extremely reactive, paving way to nucleophilic attack by endogenously occurring and ubiquitous nucleophiles like thiols. While it is easy to make a unilateral decision to not pursue the development of xenobiotics with such functionalities, we question the wisdom of such a decision. In this report, we present in vitro methodologies with appropriate examples to illustrate the ease of assessing the reactivity of the xenobiotics containing double bonds with a known nucleophile. The protocols involve simple reaction procedures followed by measurements using standard laboratory equipments (UV spectrophotometer, HPLC and LC-MS). Our data suggests that not all xenobiotics with carbon-carbon double bonds readily form a Michael's adduct product with glutathione. Hence, the criterion for dropping discovery compounds because of alpha,beta-unsaturated double bonds needs to be reconsidered.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) tours a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) tours a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

High-level QM/MM calculations support the concerted mechanism for Michael addition and covalent complex formation in thymidylate synthase.

PubMed

Kaiyawet, Nopporn; Lonsdale, Richard; Rungrotmongkol, Thanyada; Mulholland, Adrian J; Hannongbua, Supot

2015-02-10

Thymidylate synthase (TS) is a promising cancer target, due to its crucial function in thymine synthesis. It performs the reductive methylation of 2'-deoxyuridine-5'-phosphate (dUMP) to thymidine-5'-phosphate (dTMP), using N-5,10-methylene-5,6,7,8-tetrahydrofolate (mTHF) as a cofactor. After the formation of the dUMP/mTHF/TS noncovalent complex, and subsequent conformational activation, this complex has been proposed to react via nucleophilic attack (Michael addition) by Cys146, followed by methylene-bridge formation to generate the ternary covalent intermediate. Herein, QM/MM (B3LYP-D/6-31+G(d)-CHARMM27) methods are used to model the formation of the ternary covalent intermediate. A two-dimensional potential energy surface reveals that the methylene-bridged intermediate is formed via a concerted mechanism, as indicated by a single transition state on the minimum energy pathway and the absence of a stable enolate intermediate. A range of different QM methods (B3LYP, MP2 and SCS-MP2, and different basis sets) are tested for the calculation of the activation energy barrier for the formation of the methylene-bridged intermediate. We test convergence of the QM/MM results with respect to size of the QM region. Inclusion of Arg166, which interacts with the nucleophilic thiolate, in the QM region is important for reliable results; the MM model apparently does not reproduce energies for distortion of the guanidinium side chain correctly. The spin component scaled-Møller-Plessett perturbation theory (SCS-MP2) approach was shown to be in best agreement (within 1.1 kcal/mol) while the results obtained with MP2 and B3LYP also yielded acceptable values (deviating by less than 3 kcal/mol) compared with the barrier derived from experiment. Our results indicate that using a dispersion-corrected DFT method, or a QM method with an accurate treatment of electron correlation, increases the agreement between the calculated and experimental activation energy barriers, compared with the

Organocatalytic, enantioselective synthesis of benzoxaboroles via Wittig/oxa-Michael reaction Cascade of α-formyl boronic acids† †Electronic supplementary information (ESI) available. CCDC 1487136. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04522g Click here for additional data file. Click here for additional data file.

PubMed Central

Hazra, Gurupada; Maity, Sanjay; Bhowmick, Sudipto

2017-01-01

An unprecedented enantioselective synthesis of 3-substituted benzoxaboroles has been developed. An in situ generated ortho-boronic acid containing chalcone provides the chiral benzoxaboroles via an asymmetric oxa-Michael addition of hydroxyl group attached to the boronic acid triggered by the cinchona alkaloid based chiral amino-squaramide catalysts. In general, good yields with good to excellent enantioselectivities (up to 99%) were obtained. The resulting benzoxaboroles were converted to the corresponding chiral β-hydroxy ketones without affecting the enantioselectivity. PMID:28451370

Michael F. Crowley | NREL

Science.gov Websites

architectures. Crowlely's group has designed and implemented new methods and algorithms specifically for biomass , Crowley developed highly parallel methods for simulations of bio-macromolecules. Affiliated Research advanced sampling methods, Crowley and his team determine free energies such as binding of substrates

Michael's Inside Scoop: Genetics

MedlinePlus

... Vegetables Desserts Dining Decisions Mobile App – Dining Decisions Game Online Game – Dining Decisions Questions Answered Under the Microscope Xpert ... Test Your Smarts Feeling Frazzled…? Feeling Stressed Out? Game Grind Your Mind Game Kabam! Comic Creator Best ...

Michael T. Guarnieri | NREL

Science.gov Websites

accumulation," J. Proteomics (2013) "Comparative Proteomics Lends Insight into Genotype-Specific Pathogenicity," J. Proteomics (2013) "De Novo Transcriptomic Analysis of Hydrogen Production in the amino acid changes in the small envelope protein and rescued by a novel glycosolation site," J

John Michael Yarbrough | NREL

Science.gov Websites

of his time at CSM developing and using novel characterization techniques to obtain a fundamental of imaging and spectroscopy to obtain a better fundamental understanding of biological systems and

SRB Processing Facilities Media Event

NASA Image and Video Library

2016-03-01

Members of the news media view the high bay inside the Rotation, Processing and Surge Facility (RPSF) at NASA’s Kennedy Space Center in Florida. Inside the RPSF, engineers and technicians with Jacobs Engineering on the Test and Operations Support Contract, explain the various test stands. In the far corner is one of two pathfinders, or test versions, of solid rocket booster segments for NASA’s Space Launch System rocket. The Ground Systems Development and Operations Program and Jacobs are preparing the booster segments, which are inert, for a series of lifts, moves and stacking operations to prepare for Exploration Mission-1, deep-space missions and the journey to Mars.

SSPF Operational Upgrades

NASA Image and Video Library

2016-11-15

During a ribbon cutting ceremony in the high bay of the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, center director Bob Cabana, far left, is joined by Bill Dowdell, Kennedy's International Space Station technical director, Josephine Burnett, director of Exploration Research and Technology, Andy Allen, Jacobs vice president and general manager and Test and Operations Support Contract program manager, and Jeff McAlear, Jacobs director of Processing Services. The event celebrated completion of facility modifications to improve processing and free up zones tailored to a variety of needs supporting a robust assortment of space-bound hardware including NASA programs and commercial space companies.

[Confused Germanic blasphemy. Jacob Moleschott and materialistic medicine].

PubMed

de Liguori, Girolamo

2005-01-01

Starting from the reading of a recent biography of the Dutch materialistic physiologist Jacopo Moleschott (1822-1893), this article proposes a brief survey of the impact, especially in Italy, of the materialistic paradigm, not only in the field of medicine and of the natural sciences, but also in that of philosophy and of literature. From the rejection and ferocious criticisms of the Jesuits, such as Padre Previti, to the harsh ironies of Tommaseo--who, in reference to the academic lessons of Moleschott, spoke of "confused Germanic blasphemy"--, the survey proceeds to a recognition of the role and influence of Moleschott's perspective in the field of medicine, in that of science, and especially in the philosophical and epistemological debate on the relation between the experimental sciences and philosophy. The survey then proceeds to touch on the classical controversy over the Chemische Briefe of Liebig (1844), the dispute with Bufalini on the new way of thinking about the relation between physiology and pathology, and the influence exerted by the Dutch physiologist on Salvatore Tommasi. The article in the end broadens to include a rapid analysis of Moleschott's contribution to the field of literature, as well as to the more complicated debate on the natural sciences and materialism, which still today presents, beyond the outdated models of positivistic scientism, well-grounded themes of interest, if not of validity.

Dignital Biological Converter

DTIC Science & Technology

2014-01-03

DARPA Contracting Officer: Michael Blackstone Submitted by: HEATHER GOUVIS Synthetic Genomics, Inc. 11149 NORTH TORREY PINES RD LA JOLLA, CA...Contracting Officer Representative (COR) Email: salit@nist.gov Michael Blackstone DARPA Contracting Officer Michael.Blackstone@darpa.mil DARPA

Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A

NASA Astrophysics Data System (ADS)

Han, Yi-Xin; Jiang, Yan-Long; Li, Yong; Yu, Hai-Xin; Tong, Bing-Qi; Niu, Zhe; Zhou, Shi-Jie; Liu, Song; Lan, Yu; Chen, Jia-Hua; Yang, Zhen

2017-01-01

Complex natural products are a proven and rich source of disease-modulating drugs and of efficient tools for the study of chemical biology and drug discovery. The architectures of complex natural products are generally considered to represent significant barriers to efficient chemical synthesis. Here we describe a concise and efficient asymmetric synthesis of 19-dehydroxyl arisandilactone A--which belongs to a family of architecturally unique, highly oxygenated nortriterpenoids isolated from the medicinal plant Schisandra arisanensis. This synthesis takes place by means of a homo-Michael reaction, a tandem retro-Michael/Michael reaction, and Cu-catalysed intramolecular cyclopropanation as key steps. The proposed mechanisms for the homo-Michael and tandem retro-Michael/Michael reactions are supported by density functional theory (DFT) calculation. The developed chemistry may find application for the synthesis of its other family members of Schisandraceae nortriterpenoids.

Chain Dynamic Formulations for Multibody System Tracked Vehicles (Preprint)

DTIC Science & Technology

2013-03-06

Michael Wallin 1 Ahmed K. Aboubakr 1 Paramsothy Jayakumar 2 Michael D. Letherwood 2 Ashraf Hamed 1 Ahmed A. Shabana 1...5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Michael Wallin; Ahmed Aboubakr; Paramsothy Jayakumar ; Michael Letherwood; Ashraf Hamed 5d...Taylor & Francis/CRC, Boca Raton, Florida. 16. Shabana, A. A., Hamed, A. M., Mohamed, A. A., Jayakumar , P., and Letherwood, M. D. 2012, “Use of B

78 FR 42748 - Virginia Resource Advisory Committee Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... each meeting, contact: Michael Williams, Public Affairs Specialist, Supervisor's Office, 540-265-5173... building in order to view comments. FOR FURTHER INFORMATION CONTACT: Michael Williams, Public Affairs... for time for oral comments must be sent to Michael Williams, Public Affairs Specialist, George...

SRB Processing Facilities Media Event

NASA Image and Video Library

2016-03-01

Members of the news media view the high bay inside the Rotation, Processing and Surge Facility (RPSF) at NASA’s Kennedy Space Center in Florida. Kerry Chreist, with Jacobs Engineering on the Test and Operations Support Contract, talks with a reporter about the booster segments for NASA’s Space Launch System (SLS) rocket. In the far corner, in the vertical position, is one of two pathfinders, or test versions, of solid rocket booster segments for the SLS rocket. The Ground Systems Development and Operations Program and Jacobs are preparing the booster segments, which are inert, for a series of lifts, moves and stacking operations to prepare for Exploration Mission-1, deep-space missions and the journey to Mars.

Indulging anxiety: human enhancement from a Protestant perspective.

PubMed

Hanson, Mark J

1999-08-01

At the heart of any ethics of human enhancement must be some normative assumptions about human nature. The purpose of this essay is to draw on themes from a Protestant theological anthropology to provide a basis for understanding and evaluating the tension between maintaining our humanity and enhancing it. Drawing primarily on the work of theologian Reinhold Niebuhr, I interpret enhancement as proceeding from the anxiety that characterizes human experience at the juncture of freedom and finiteness. Religious and moral dimensions of human sinfulness are considered in relation to cultural values that motivate human enhancement generally. I employ these dimensions in a series of benchmarks to suggest a background of theological, anthropological, and moral considerations against which enhancement is not to be condemmed but rather critically evaluated.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (top) discusses the inner workings of Shuttle Atlantis in Orbiter Processing Facility Bay 1 with a United Space Alliance (USA) technician (bottom). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (top) discusses the inner workings of Shuttle Atlantis in Orbiter Processing Facility Bay 1 with a United Space Alliance (USA) technician (bottom). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right) discusses a speed brake on Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (left). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right) discusses a speed brake on Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (left). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) is given a tour of a solid rocket booster (SRB) retrieval ship by United Space Alliance (USA) employee Joe Chaput (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) is given a tour of a solid rocket booster (SRB) retrieval ship by United Space Alliance (USA) employee Joe Chaput (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

77 FR 9970 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

..., 2010. Leased Workers: Jacobs PSG, Middough Assoc, Adecco, CDI, Becht, etc. 81,022 Apex Tool Group..., AR February 13, 2010. Enterprises, Whirlpool Cost Center. Negative Determinations for Worker...

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush from NASA Headquarters stating his goals for NASA’s new mission. Seated in the front row, left to right, are Ken Aguilar, chief, Equal Opportunity office; Lisa Malone, director of External Affairs; Bruce Buckingham, assistant to Dr. Woodrow Whitlow, KSC deputy director; Dr. Whitlow; Shannon Roberts, with External Affairs; Howard DeCastro, vice president and Space Shuttle program manager, United Space Alliance; and Bill Pickavance vice president and associate program manager of Florida Operations, USA. The President’s goals are completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

NASA Image and Video Library

2004-01-14

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush from NASA Headquarters stating his goals for NASA’s new mission. Seated in the front row, left to right, are Ken Aguilar, chief, Equal Opportunity office; Lisa Malone, director of External Affairs; Bruce Buckingham, assistant to Dr. Woodrow Whitlow, KSC deputy director; Dr. Whitlow; Shannon Roberts, with External Affairs; Howard DeCastro, vice president and Space Shuttle program manager, United Space Alliance; and Bill Pickavance vice president and associate program manager of Florida Operations, USA. The President’s goals are completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

Hydromorphone overdose

MedlinePlus

... Updated by: Jacob L. Heller, MD, MHA, Emergency Medicine, Emeritus, Virginia Mason Medical Center, Seattle, WA. ... as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is ...

Galbraith and His Predecessors: Notes on the New Television Teachers

ERIC Educational Resources Information Center

Sullivan, Patrick J.

1978-01-01

A critique of John Kenneth Galbraith's "Age of Uncertainty" through comparison of style developed in Sir Kenneth Clark's "Civilization," Alistair Cooke's "America," and Jacob Bronowski's "The Ascent of Man." (RAO)

SRB Processing Facilities Media Event

NASA Image and Video Library

2016-03-01

Members of the news media view the high bay inside the Rotation, Processing and Surge Facility (RPSF) at NASA’s Kennedy Space Center in Florida. Kerry Chreist, with Jacobs Engineering on the Test and Operations Support Contract, explains the various test stands and how they will be used to prepare booster segments for NASA’s Space Launch System (SLS) rocket. In the far corner, in the vertical position, is one of two pathfinders, or test versions, of solid rocket booster segments for the SLS rocket. The Ground Systems Development and Operations Program and Jacobs are preparing the booster segments, which are inert, for a series of lifts, moves and stacking operations to prepare for Exploration Mission-1, deep-space missions and the journey to Mars.

76 FR 18740 - Notice of Submission for OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

... the Jacob K. Javits Fellowship Program for graduate study in the arts, humanities, and social sciences... meeting the program's objectives and allows program staff to monitor and evaluate time-to-degree...

Man - A Machine or a Self?

ERIC Educational Resources Information Center

Kneipp, Janet R.

1974-01-01

Article described the conceptual outlook of a great teacher, Jacob Bronowski, who stressed in his new film series how imagination is influential in presenting scientific material for student audiences. (Author/RK)

Veteran’s Health Care Issues

DTIC Science & Technology

2007-11-30

Affairs Dr. Michael J. Kussman , in U.S. Congress, House Committee on Veterans’ Affairs Subcommittee on Oversight and Investigations, hearing on...Health, Department of Veterans Affairs, Michael Kussman , in U.S. Congress, House Committee on Appropriations, Subcommittee on Military Construction...Department of Veterans Affairs Dr. Michael J. Kussman , in U.S. Congress, House Committee on Veterans’ Affairs Subcommittee on Oversight and