Sample records for jalakas paul saks

  1. Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus

    PubMed Central

    Neamah, Maan M.; Mir-Sanchis, Ignacio; López-Sanz, María; Acosta, Sonia; Baquedano, Ignacio; Haag, Andreas F.

    2017-01-01

    Abstract DNA-single strand annealing proteins (SSAPs) are recombinases frequently encoded in the genome of many bacteriophages. As SSAPs can promote homologous recombination among DNA substrates with an important degree of divergence, these enzymes are involved both in DNA repair and in the generation of phage mosaicisms. Here, analysing Sak and Sak4 as representatives of two different families of SSAPs present in phages infecting the clinically relevant bacterium Staphylococcus aureus, we demonstrate for the first time that these enzymes are absolutely required for phage reproduction. Deletion of the genes encoding these enzymes significantly reduced phage replication and the generation of infectious particles. Complementation studies revealed that these enzymes are required both in the donor (after prophage induction) and in the recipient strain (for infection). Moreover, our results indicated that to perform their function SSAPs require the activity of their cognate single strand binding (Ssb) proteins. Mutational studies demonstrated that the Ssb proteins are also required for phage replication, both in the donor and recipient strain. In summary, our results expand the functions attributed to the Sak and Sak4 proteins, and demonstrate that both SSAPs and Ssb proteins are essential for the life cycle of temperate staphylococcal phages. PMID:28475766

  2. Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus.

    PubMed

    Neamah, Maan M; Mir-Sanchis, Ignacio; López-Sanz, María; Acosta, Sonia; Baquedano, Ignacio; Haag, Andreas F; Marina, Alberto; Ayora, Silvia; Penadés, José R

    2017-06-20

    DNA-single strand annealing proteins (SSAPs) are recombinases frequently encoded in the genome of many bacteriophages. As SSAPs can promote homologous recombination among DNA substrates with an important degree of divergence, these enzymes are involved both in DNA repair and in the generation of phage mosaicisms. Here, analysing Sak and Sak4 as representatives of two different families of SSAPs present in phages infecting the clinically relevant bacterium Staphylococcus aureus, we demonstrate for the first time that these enzymes are absolutely required for phage reproduction. Deletion of the genes encoding these enzymes significantly reduced phage replication and the generation of infectious particles. Complementation studies revealed that these enzymes are required both in the donor (after prophage induction) and in the recipient strain (for infection). Moreover, our results indicated that to perform their function SSAPs require the activity of their cognate single strand binding (Ssb) proteins. Mutational studies demonstrated that the Ssb proteins are also required for phage replication, both in the donor and recipient strain. In summary, our results expand the functions attributed to the Sak and Sak4 proteins, and demonstrate that both SSAPs and Ssb proteins are essential for the life cycle of temperate staphylococcal phages. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  3. An evaluation of sex-age-kill (SAK) model performance

    USGS Publications Warehouse

    Millspaugh, Joshua J.; Skalski, John R.; Townsend, Richard L.; Diefenbach, Duane R.; Boyce, Mark S.; Hansen, Lonnie P.; Kammermeyer, Kent

    2009-01-01

    The sex-age-kill (SAK) model is widely used to estimate abundance of harvested large mammals, including white-tailed deer (Odocoileus virginianus). Despite a long history of use, few formal evaluations of SAK performance exist. We investigated how violations of the stable age distribution and stationary population assumption, changes to male or female harvest, stochastic effects (i.e., random fluctuations in recruitment and survival), and sampling efforts influenced SAK estimation. When the simulated population had a stable age distribution and λ > 1, the SAK model underestimated abundance. Conversely, when λ < 1, the SAK overestimated abundance. When changes to male harvest were introduced, SAK estimates were opposite the true population trend. In contrast, SAK estimates were robust to changes in female harvest rates. Stochastic effects caused SAK estimates to fluctuate about their equilibrium abundance, but the effect dampened as the size of the surveyed population increased. When we considered both stochastic effects and sampling error at a deer management unit scale the resultant abundance estimates were within ±121.9% of the true population level 95% of the time. These combined results demonstrate extreme sensitivity to model violations and scale of analysis. Without changes to model formulation, the SAK model will be biased when λ ≠ 1. Furthermore, any factor that alters the male harvest rate, such as changes to regulations or changes in hunter attitudes, will bias population estimates. Sex-age-kill estimates may be precise at large spatial scales, such as the state level, but less so at the individual management unit level. Alternative models, such as statistical age-at-harvest models, which require similar data types, might allow for more robust, broad-scale demographic assessments.

  4. Novel spiroimidazopyridine derivative SAK3 improves methimazole-induced cognitive deficits in mice.

    PubMed

    Noreen, Husain; Yabuki, Yasushi; Fukunaga, Kohji

    2017-09-01

    Methimazole (MMI) is a first-line therapy used to manage hyperthyroidism and Graves' disease. Despite its therapeutic benefit, chronic MMI administration can lead to hypothyroidism and perturb brain homeostasis in patients, resulting in neuropsychiatric disorders such as depression and cognitive dysfunction. We recently developed the spiroimidazopyridine derivative SAK3 as cognitive enhancer; however, mechanisms underlying its activity remained unclear. Here, we show that SAK3 potentially improves cognitive impairment seen following MMI-induced hypothyroidism. Twenty-four hours after MMI (75 mg/kg, i.p.) treatment, we administered SAK3 (0.1, 0.5 and 1 mg/kg, p.o.) to mice daily for 7 days. MMI treatment alone disrupted olfactory bulb (OB) glomerular structure, as assessed by staining with the olfactory marker protein (OMP), reduced the number of choline acetyl transferase (ChAT)-immunoreactive neurons in medial septum (MS), and significantly impaired cognition. SAK3 (0.5 and 1 mg/kg, p.o.) administration significantly restored the number of cholinergic MS neurons in MMI-treated mice, and SAK3 treatment at a higher dose significantly improved cognitive deficits seen in MMI-treated control mice. Overall, our study suggests that SAK3 treatment could antagonize such impairment in patients with hypothyroidism. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Inactivation of DNA-Binding Response Regulator Sak189 Abrogates β-Antigen Expression and Affects Virulence of Streptococcus agalactiae

    PubMed Central

    Rozhdestvenskaya, Anastasia S.; Totolian, Artem A.; Dmitriev, Alexander V.

    2010-01-01

    Background Streptococcus agalactiae is able to colonize numerous tissues employing different mechanisms of gene regulation, particularly via two-component regulatory systems. These systems sense the environmental stimuli and regulate expression of the genes including virulence genes. Recently, the novel two-component regulatory system Sak188/Sak189 was identified. In S. agalactiae genome, it was adjacent to the bac gene encoding for β-antigen, an important virulence factor. Methodology/Principal Findings In this study, the sak188 and sak189 genes were inactivated, and the functional role of Sak188/Sak189 two-component system in regulation of the β-antigen expression was investigated. It was demonstrated that both transcription of bac gene and expression of encoded β-antigen were controlled by Sak189 response regulator, but not Sak188 histidine kinase. It was also found that the regulation occurred at transcriptional level. Finally, insertional inactivation of sak189 gene, but not sak188 gene, significantly affected virulent properties of S. agalactiae. Conclusions/Significance Sak189 response regulator is necessary for activation of bac gene transcription. It also controls the virulent properties of S. agalactiae. Given that the primary functional role of Sak188/Sak189 two-component systems is a control of bac gene transcription, this system can be annotated as BgrR/S (bac gene regulatory system). PMID:20419089

  6. New derivative of staphylokinase SAK-RGD-K2-Hirul exerts thrombolytic effects in the arterial thrombosis model in rats.

    PubMed

    Szemraj, Janusz; Zakrzeska, Agnieszka; Brown, George; Stankiewicz, Adrian; Gromotowicz, Anna; Grędziński, Tomasz; Chabielska, Ewa

    2011-01-01

    SAK-RGD-K2-Hir and SAK-RGD-K2-Hirul are recombinant proteins that are derivatives of r-SAK (recombinant staphylokinase). They are characterized by their fibrin-specific plasminogen activation properties and their antithrombin and antiplatelet activities. The difference between these proteins is the presence of the antithrombotic fragment (hirudin or hirulog) in the C-terminal portion of the r-SAK. The aim of the present study was to examine the thrombolytic potentials of SAK-RGD-K2-Hir and SAK-RGD-K2-Hirul in an electrically induced carotid artery thrombosis model in rats and to compare the potentials to that of r-SAK. We determined that a bolus injection of SAK-RGD-K2-Hirul was more effective than one of r-SAK in the improvement and maintenance of carotid patency and in arterial thrombus weight reduction; however, it had the same potency as SAK-RGD-K2-Hir. The bleeding time, prothrombin time and activated partial thromboplastin time were significantly prolonged in the animals that were treated with either dose (1.5 or 3.0 mg/kg) of SAK-RGD-K2-Hir or SAK-RGD-K2-Hirul, whereas no changes were observed in the plasma fibrinogen concentration or the α2 plasmin inhibitor level. r-SAK alone did not change the bleeding time or coagulation parameters. In conclusion, our findings demonstrate the thrombolytic activity of intravenous bolus injection of the novel thrombolytic agent SAK-RGD-K2-Hirul in rats. Although this protein compares favorably with r-SAK, we were unable to show the presence of any beneficial effects of SAK-RGD-K2-Hirul over those of SAK-RGD-K2-Hir. Furthermore, our results suggest that high doses of SAK-RGD-K2-Hirul bear the risk of bleeding.

  7. Characterization of sakA gene from pathogenic dimorphic fungus Penicillium marneffei.

    PubMed

    Nimmanee, Panjaphorn; Woo, Patrick C Y; Kummasook, Aksarakorn; Vanittanakom, Nongnuch

    2015-01-01

    Eukaryotes utilize stress activated protein kinase (SAPK) pathways to adapt to environmental stress, including heat, osmotic, oxidative or nutrient stresses. Penicillium marneffei (Talaromyces marneffei), the dimorphic pathogenic fungus that can cause disseminated mycosis in HIV-infected patients, has to encounter various types of stresses both outside and inside host cells. However, the strategies used by this fungus in response to these stresses are still unclear. In this report, the stress-activated kinase (sakA) gene of P. marneffei was characterized and the roles of this gene on various stress conditions were studied. The sakA gene deletion mutant was constructed using the split marker method. The phenotypes and sensitivities to varieties of stresses, including osmotic, oxidative, heat and cell wall stresses of the deletion mutant were compared with the wild type and the sakA complemented strains. Results demonstrated that the P. marneffei sakA gene encoded a putative protein containing TXY phosphorylation lip found in the stress high osmolarity glycerol 1 (Hog1)/Spc1/p38 MAPK family, and that this gene was involved not only in tolerance against oxidative and heat stresses, but also played a role in asexual development, chitin deposition, yeast cell generation in vitro and survival inside mouse and human macrophages. Copyright © 2014 Elsevier GmbH. All rights reserved.

  8. Phosphoprotein SAK1 is a regulator of acclimation to singlet oxygen in Chlamydomonas reinhardtii.

    PubMed

    Wakao, Setsuko; Chin, Brian L; Ledford, Heidi K; Dent, Rachel M; Casero, David; Pellegrini, Matteo; Merchant, Sabeeha S; Niyogi, Krishna K

    2014-05-23

    Singlet oxygen is a highly toxic and inevitable byproduct of oxygenic photosynthesis. The unicellular green alga Chlamydomonas reinhardtii is capable of acclimating specifically to singlet oxygen stress, but the retrograde signaling pathway from the chloroplast to the nucleus mediating this response is unknown. Here we describe a mutant, singlet oxygen acclimation knocked-out 1 (sak1), that lacks the acclimation response to singlet oxygen. Analysis of genome-wide changes in RNA abundance during acclimation to singlet oxygen revealed that SAK1 is a key regulator of the gene expression response during acclimation. The SAK1 gene encodes an uncharacterized protein with a domain conserved among chlorophytes and present in some bZIP transcription factors. The SAK1 protein is located in the cytosol, and it is induced and phosphorylated upon exposure to singlet oxygen, suggesting that it is a critical intermediate component of the retrograde signal transduction pathway leading to singlet oxygen acclimation.DOI: http://dx.doi.org/10.7554/eLife.02286.001. Copyright © 2014, Wakao et al.

  9. Sak4 of Phage HK620 Is a RecA Remote Homolog With Single-Strand Annealing Activity Stimulated by Its Cognate SSB Protein

    PubMed Central

    Hutinet, Geoffrey; Besle, Arthur; Son, Olivier; McGovern, Stephen; Guerois, Raphaël; Petit, Marie-Agnès; Ochsenbein, Françoise; Lecointe, François

    2018-01-01

    Bacteriophages are remarkable for the wide diversity of proteins they encode to perform DNA replication and homologous recombination. Looking back at these ancestral forms of life may help understanding how similar proteins work in more sophisticated organisms. For instance, the Sak4 family is composed of proteins similar to the archaeal RadB protein, a Rad51 paralog. We have previously shown that Sak4 allowed single-strand annealing in vivo, but only weakly compared to the phage λ Redβ protein, highlighting putatively that Sak4 requires partners to be efficient. Here, we report that the purified Sak4 of phage HK620 infecting Escherichia coli is a poorly efficient annealase on its own. A distant homolog of SSB, which gene is usually next to the sak4 gene in various species of phages, highly stimulates its recombineering activity in vivo. In vitro, Sak4 binds single-stranded DNA and performs single-strand annealing in an ATP-dependent way. Remarkably, the single-strand annealing activity of Sak4 is stimulated by its cognate SSB. The last six C-terminal amino acids of this SSB are essential for the binding of Sak4 to SSB-covered single-stranded DNA, as well as for the stimulation of its annealase activity. Finally, expression of sak4 and ssb from HK620 can promote low-level of recombination in vivo, though Sak4 and its SSB are unable to promote strand exchange in vitro. Regarding its homology with RecA, Sak4 could represent a link between two previously distinct types of recombinases, i.e., annealases that help strand exchange proteins and strand exchange proteins themselves. PMID:29740405

  10. Sak4 of Phage HK620 Is a RecA Remote Homolog With Single-Strand Annealing Activity Stimulated by Its Cognate SSB Protein.

    PubMed

    Hutinet, Geoffrey; Besle, Arthur; Son, Olivier; McGovern, Stephen; Guerois, Raphaël; Petit, Marie-Agnès; Ochsenbein, Françoise; Lecointe, François

    2018-01-01

    Bacteriophages are remarkable for the wide diversity of proteins they encode to perform DNA replication and homologous recombination. Looking back at these ancestral forms of life may help understanding how similar proteins work in more sophisticated organisms. For instance, the Sak4 family is composed of proteins similar to the archaeal RadB protein, a Rad51 paralog. We have previously shown that Sak4 allowed single-strand annealing in vivo , but only weakly compared to the phage λ Redβ protein, highlighting putatively that Sak4 requires partners to be efficient. Here, we report that the purified Sak4 of phage HK620 infecting Escherichia coli is a poorly efficient annealase on its own. A distant homolog of SSB, which gene is usually next to the sak4 gene in various species of phages, highly stimulates its recombineering activity in vivo. In vitro , Sak4 binds single-stranded DNA and performs single-strand annealing in an ATP-dependent way. Remarkably, the single-strand annealing activity of Sak4 is stimulated by its cognate SSB. The last six C-terminal amino acids of this SSB are essential for the binding of Sak4 to SSB-covered single-stranded DNA, as well as for the stimulation of its annealase activity. Finally, expression of sak4 and ssb from HK620 can promote low-level of recombination in vivo , though Sak4 and its SSB are unable to promote strand exchange in vitro . Regarding its homology with RecA, Sak4 could represent a link between two previously distinct types of recombinases, i.e., annealases that help strand exchange proteins and strand exchange proteins themselves.

  11. Shifting the fermentative/oxidative balance in Saccharomyces cerevisiae by transcriptional deregulation of Snf1 via overexpression of the upstream activating kinase Sak1p.

    PubMed

    Raab, Andreas M; Hlavacek, Verena; Bolotina, Natalia; Lang, Christine

    2011-03-01

    With the aim to reduce fermentation by-products and to promote respiratory metabolism by shifting the fermentative/oxidative balance, we evaluated the constitutive overexpression of the SAK1 and HAP4 genes in Saccharomyces cerevisiae. Sak1p is one of three kinases responsible for the phosphorylation, and thereby the activation, of the Snf1p complex, while Hap4p is the activator subunit of the Hap2/3/4/5 transcriptional complex. We compared the physiology of a SAK1-overexpressing strain with that of a strain overexpressing the HAP4 gene in wild-type and sdh2 deletion (respiratory-deficient) backgrounds. Both SAK1 and HAP4 overexpressions led to the upregulation of glucose-repressed genes and to reduced by-product formation rates (ethanol and glycerol). SAK1 overexpression had a greater impact on growth rates than did HAP4 overexpression. Elevated transcript levels of SAK1, but not HAP4, resulted in increased biomass yields in batch cultures grown on glucose (aerobic and excess glucose) as well as on nonfermentable carbon sources. SAK1 overexpression, but not the combined overexpression of SAK1 and HAP4 or the overexpression of HAP4 alone, restored growth on ethanol in an sdh2 deletion strain. In glucose-grown shake flask cultures, the sdh2 deletion strain with SAK1 and HAP4 overexpression produced succinic acid at a titer of 8.5 g liter(-1) and a yield of 0.26 mol (mol glucose)(-1) within 216 h. We here report for the first time that a constitutively high level of expression of SAK1 alleviates glucose repression and shifts the fermentative/oxidative balance under both glucose-repressed and -derepressed conditions.

  12. Forgotten evidence: A mixed methods study of why sexual assault kits (SAKs) are not submitted for DNA forensic testing.

    PubMed

    Campbell, Rebecca; Fehler-Cabral, Giannina; Bybee, Deborah; Shaw, Jessica

    2017-10-01

    Throughout the United States, hundreds of thousands of sexual assault kits (SAKs) (also termed "rape kits") have not been submitted by the police for forensic DNA testing. DNA evidence can help sexual assault investigations and prosecutions by identifying offenders, revealing serial offenders through DNA matches across cases, and exonerating those who have been wrongly accused. In this article, we describe a 5-year action research project conducted with 1 city that had large numbers of untested SAKs-Detroit, Michigan-and our examination into why thousands of rape kits in this city were never submitted for forensic DNA testing. This mixed methods study combined ethnographic observations and qualitative interviews to identify stakeholders' perspectives as to why rape kits were not routinely submitted for testing. Then, we quantitatively examined whether these factors may have affected police practices regarding SAK testing, as evidenced by predictable changes in SAK submission rates over time. Chronic resource scarcity only partially explained why the organizations that serve rape victims-the police, crime lab, prosecution, and victim advocacy-could not test all rape kits, investigate all reported sexual assaults, and support all rape survivors. SAK submission rates significantly increased once criminal justice professionals in this city had full access to the FBI DNA forensic database Combined DNA Index System (CODIS), but even then, most SAKs were still not submitted for DNA testing. Building crime laboratories' capacities for DNA testing and training police on the utility of forensic evidence and best practices in sexual assault investigations can help remedy, and possibly prevent, the problem of untested rape kits. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  13. Role of the Talaromyces marneffei (Penicillium marneffei) sakA gene in nitrosative stress response, conidiation and red pigment production.

    PubMed

    Nimmanee, Panjaphorn; Tam, Emily W T; Woo, Patrick C Y; Vanittanakom, Pramote; Vanittanakom, Nongnuch

    2017-04-01

    Stress-activated MAPK pathways are systems used to regulate the stress adaptation of most fungi. It has been shown that in Talaromyces marneffei (Penicillium marneffei), a pathogenic dimorphic fungus, the sakA gene is involved, not only in tolerance against oxidative and heat stresses, but also in playing a role in asexual development, yeast cell generation in vitro and survival inside macrophage cell lines. In this study, the role of the T. marneffei sakA gene on the nitrosative stress response and the regulation of gene expression were investigated. The susceptibility of the sakA mutant to NaNO2 was investigated using drop dilution assay and the expression of genes of interest were determined by RT-PCR, comparing them to the wild-type and complemented strains. The results demonstrated that the T. marneffei sakA gene played a role in the stress response to NaNO2, the expression of genes functioning in conidial development (brlA, abaA and wetA) and red pigment biosynthesis (pks3, rp1, rp2 and rp3). These findings suggest that T. marneffei sakA is broadly involved in a wide variety of cell activities, including stress response, cell morphogenesis, asexual development and pigmentation. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. A Reflective Conversation with Ugur Sak: Gifted Education in Turkey

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Sak, Ugur

    2015-01-01

    In this reflective conversation, Ugur Sak discusses the current "state of the art" of gifted education in Turkey. He reviews the use of enrichment, discusses acceleration and reviews curricular procedures in Turkey. He responds to questions about the identification of gifted students and discusses the age old debate of talent versus…

  15. Acute Treatment with T-Type Calcium Channel Enhancer SAK3 Reduces Cognitive Impairments Caused by Methimazole-Induced Hypothyroidism Via Activation of Cholinergic Signaling.

    PubMed

    Husain, Noreen; Yabuki, Yasushi; Shinoda, Yasuharu; Fukunaga, Kohji

    2018-01-01

    Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) injection of methimazole (MMI; 75 mg/kg), thereby improving cognition. Here, we evaluated the acute effect of SAK3 on cognitive impairments and its mechanism of action following the induction of hypothyroidism. Hypothyroidism was induced by 2 injections of MMI (75 mg/kg, i.p.) administered once per week. Four weeks after the final MMI treatment, MMI-treated mice showed reduced serum thyroxine (T4) levels and cognitive impairments without depression-like behaviors. Although acute SAK3 (1.0 mg/kg, p.o.) administration failed to ameliorate the decreased T4 levels and histochemical destruction of the glomerular structure, acute SAK3 (1.0 mg/kg, p.o.) administration significantly reduced cognitive impairments in MMI-treated mice. Importantly, the α7 nicotinic acetylcholine receptor (nAChR)-selective inhibitor methyllycaconitine (MLA; 12 mg/kg, i.p.) and T-type calcium channel-specific blocker NNC 55-0396 (25 mg/kg, i.p.) antagonized the acute effect of SAK3 on memory deficits in MMI-treated mice. We also confirmed that acute SAK3 administration does not rescue reduced olfactory marker protein or choline acetyltransferase immunoreactivity levels in the olfactory bulb or medial septum. Taken together, these results suggest that SAK3 has the ability to improve the cognitive decline caused by hypothyroidism directly through activation of nAChR signaling and T-type calcium channels. © 2018 S. Karger AG, Basel.

  16. The National Problem of Untested Sexual Assault Kits (SAKs): Scope, Causes, and Future Directions for Research, Policy, and Practice.

    PubMed

    Campbell, Rebecca; Feeney, Hannah; Fehler-Cabral, Giannina; Shaw, Jessica; Horsford, Sheena

    2015-12-23

    Victims of sexual assault are often advised to have a medical forensic exam and sexual assault kit (SAK; also termed a "rape kit") to preserve physical evidence (e.g., semen, blood, and/or saliva samples) to aid in the investigation and prosecution of the crime. Law enforcement are tasked with submitting the rape kit to a forensic laboratory for DNA (deoxyribonucleic acid) analysis, which can be instrumental in identifying offenders in previously unsolved crimes, confirming identify in known-offender assaults, discovering serial rapists, and exonerating individuals wrongly accused. However, a growing number of media stories, investigative advocacy projects, and social science studies indicate that police are not routinely submitting SAKs for forensic testing, and instead rape kits are placed in evidence storage, sometimes for decades. This review article examines the growing national problem of untested rape kits by summarizing current research on the number of untested SAKs in the United States and exploring the underlying reasons why police do not submit this evidence for DNA testing. Recommendations for future research that can guide policy and practice are discussed. © The Author(s) 2015.

  17. The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence

    PubMed Central

    Alves de Castro, Patrícia; dos Reis, Thaila Fernanda; Dolan, Stephen K.; Manfiolli, Adriana Oliveira; Brown, Neil Andrew; Jones, Gary W.; Doyle, Sean; Riaño-Pachón, Diego M.; Squina, Fábio Márcio; Caldana, Camila; Singh, Ashutosh; Del Poeta, Maurizio; Hagiwara, Daisuke; Silva-Rocha, Rafael; Goldman, Gustavo H.

    2016-01-01

    Summary The serine-threonine kinase TOR, the Target of Rapamycin, is an important regulator of nutrient, energy and stress signaling in eukaryotes. Sch9, a Ser/Thr kinase of AGC family (the cAMP-dependent PKA, cGMP- dependent protein kinase G and phospholipid-dependent protein kinase C family), is a substrate of TOR. Here, we characterized the fungal opportunistic pathogen Aspergillus fumigatus Sch9 homologue (SchA). The schA null mutant was sensitive to rapamycin, high concentrations of calcium, hyperosmotic stress and SchA was involved in iron metabolism. The ΔschA null mutant showed increased phosphorylation of SakA, the A. fumigatus Hog1 homologue. The schA null mutant has increased and decreased trehalose and glycerol accumulation, respectively, suggesting SchA performs different roles for glycerol and trehalose accumulation during osmotic stress. The schA was transcriptionally regulated by osmotic stress and this response was dependent on SakA and MpkC. The double ΔschA ΔsakA and ΔschA ΔmpkC mutants were more sensitive to osmotic stress than the corresponding parental strains. Transcriptomics and proteomics identified direct and indirect targets of SchA post-exposure to hyperosmotic stress. Finally, ΔschA was avirulent in a low dose murine infection model. Our results suggest there is a complex network of interactions amongst the A. fumigatus TOR, SakA and SchA pathways. PMID:27538790

  18. The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.

    PubMed

    Alves de Castro, Patrícia; Dos Reis, Thaila Fernanda; Dolan, Stephen K; Oliveira Manfiolli, Adriana; Brown, Neil Andrew; Jones, Gary W; Doyle, Sean; Riaño-Pachón, Diego M; Squina, Fábio Márcio; Caldana, Camila; Singh, Ashutosh; Del Poeta, Maurizio; Hagiwara, Daisuke; Silva-Rocha, Rafael; Goldman, Gustavo H

    2016-11-01

    The serine-threonine kinase TOR, the Target of Rapamycin, is an important regulator of nutrient, energy and stress signaling in eukaryotes. Sch9, a Ser/Thr kinase of AGC family (the cAMP-dependent PKA, cGMP- dependent protein kinase G and phospholipid-dependent protein kinase C family), is a substrate of TOR. Here, we characterized the fungal opportunistic pathogen Aspergillus fumigatus Sch9 homologue (SchA). The schA null mutant was sensitive to rapamycin, high concentrations of calcium, hyperosmotic stress and SchA was involved in iron metabolism. The ΔschA null mutant showed increased phosphorylation of SakA, the A. fumigatus Hog1 homologue. The schA null mutant has increased and decreased trehalose and glycerol accumulation, respectively, suggesting SchA performs different roles for glycerol and trehalose accumulation during osmotic stress. The schA was transcriptionally regulated by osmotic stress and this response was dependent on SakA and MpkC. The double ΔschA ΔsakA and ΔschA ΔmpkC mutants were more sensitive to osmotic stress than the corresponding parental strains. Transcriptomics and proteomics identified direct and indirect targets of SchA post-exposure to hyperosmotic stress. Finally, ΔschA was avirulent in a low dose murine infection model. Our results suggest there is a complex network of interactions amongst the A. fumigatus TOR, SakA and SchA pathways. © 2016 John Wiley & Sons Ltd.

  19. The opposite role of two UBA-UBX containing proteins, p47 and SAKS1 in the degradation of a single ERAD substrate, α-TCR.

    PubMed

    Park, Eun Sil; Yoo, Yung Joon; Elangovan, Muthukumar

    2017-01-01

    The UBA-UBX domain-containing proteins can interact with ubiquitinated substrates and p97 during endoplasmic reticulum-associated degradation (ERAD). Here, we found that the expressions of all UBA-UBX genes p47, SAKS1, UBXD8, FAF1, and UBXD7 were elevated upon ER stress, albeit with different levels. Of which p47, SAKS1, and UBXD8 are 'immediate' respondents whereas FAF1 and UBXD7 were 'late' respondents to ER stress. Interestingly, the expression of specific UBA-UBX genes were altered in cells stably expressing three different ERAD substrates such as α-TCR, α1-antitrypsin, and δCD3. We first found that p47 and UBXD8 expression levels were increased in α-TCR and α1-antitrypsin stable cell lines, respectively, whereas SAKS1 expression level was reduced in all the three ERAD substrates tested. Of note, we also found p47 promotes, whereas SASK1 delays the degradation of a single ERAD substrate, α-TCR. Additionally, we found that SAKS1 selectively inhibits the degradation of ERAD substrates without affecting cytosolic proteasomal substrates. Taken together, our results identified that UBA-UBX proteins possess substrate selectivity and opposite role of two different UBA-UBX proteins in the degradation of a single ERAD substrate.

  20. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT: PAINT OVERSPRAY ARRESTOR, KOCH FILTER CORPORATION MULTI-SAK 6FZ159-S

    EPA Science Inventory

    The report gives results of March 19-23, 1999, tests of Koch Filter Corporation's Multi-Sak 6FZ159-S paint overspray arrestor (POA) as part of an evaluation of POAs by EPA's Air Pollution Control Technology (APCT) Environmental Technology Verification (ETV) Program. The basic per...

  1. Paul Veers | NREL

    Science.gov Websites

    Veers Photo of Paul Veers Paul Veers Group Research Manager III-Mechanical Engineering Paul.Veers @nrel.gov | 303-384-7197 Paul Veers is the Chief Engineer at the NWTC and represents NREL on DOE's Staff at Sandia National Laboratories. Paul has authored over 70 articles, papers, book chapters, and

  2. Paul Denholm | NREL

    Science.gov Websites

    Denholm Photo of Paul Denholm Paul Denholm Principal Energy Analyst Paul.Denholm@nrel.gov | 303-384 -7488 Paul Denholm is a member of the Grid Systems Analysis Group in the Strategic Energy Analysis Center. Paul is a leading researcher in grid applications for energy storage and solar energy. He

  3. Paul Fleming | NREL

    Science.gov Websites

    Paul Fleming Photo of Paul Fleming Paul Fleming Researcher IV-Control Engineering Paul.Fleming analysis of control systems for wind energy. Paul co-designed the control system used for field testing of advanced control systems on the CARTs, located at the NWTC. Since joining NREL, he has researched topics

  4. Paul Frampton

    NASA Astrophysics Data System (ADS)

    Williams, Heather A.

    2013-01-01

    I was astonished by an article that appeared on physicsworld.com in November about the physicist Paul Frampton and his imprisonment for attempted cocaine smuggling ("Paul Frampton hit by 56-month drugs sentence", 22 November 2012).

  5. Debating Paul

    ERIC Educational Resources Information Center

    Torbett, David

    2007-01-01

    This classroom note describes the lessons I learned from the use of formal debates during the two semesters I taught "Paul and Early Christianity" to undergraduates at a liberal arts college in Ohio. The purpose of the course was primarily to give students the exegetical skills to understand Paul in his own context. The secondary purpose…

  6. Maniac Talk - Paul Newman

    NASA Image and Video Library

    2015-02-25

    Paul Newman Maniac Lecture, February 25, 2015 NASA climate scientist Dr. Paul Newman presented a Maniac Talk entitled "Some pretty good rules for a career: Newman's own lessons." Paul traced his journey from middle of Seattle, where he grew up, moved to rural Iowa for graduate school, and made his way to NASA/GSFC in 1984, and discussed lessons to be learned from the ozone depletion story.

  7. Electronegativity Equalization with Pauling Units.

    ERIC Educational Resources Information Center

    Bratsch, Steven G.

    1984-01-01

    Discusses electronegativity equalization using Pauling units. Although Pauling has qualitatively defined electronegativity as the power of an atom in a molecule to attract electrons to itself, Pauling electronegativities are treated in this paper as prebonded, isolated-atom quantities. (JN)

  8. Paul Torcellini | NREL

    Science.gov Websites

    | 303-384-7528 Paul is the principal engineer for the Commercial Buildings Research Group and has been at the NREL for 19 years. Prior to this role, he was the group manager for the Commercial Buildings articles related to energy efficiency and zero-energy commercial buildings. Among his many awards, Paul has

  9. Linus Pauling and sickle cell disease.

    PubMed

    Eaton, William A

    2003-01-01

    The 1949 paper by Linus Pauling et al. [Science 110 (1949) 543-548] describing the discovery of sickle cell anemia as the first molecular disease had a major impact on biology and medicine. Inspired by the scholarly works of John Edsall on the history of hemoglobin research, I present a brief retrospective analysis of Pauling's paper. This is followed by some personal recollections of Edsall and Pauling.

  10. Paul Bert

    NASA Technical Reports Server (NTRS)

    Colin, J.

    1978-01-01

    This biographical article on Paul Bert highlights his studies on the physiology of respiration and barometric pressure and, in particular his contributions to the understanding of hypoxia, hyperoxia and anesthesia.

  11. Paul Dirac

    NASA Astrophysics Data System (ADS)

    Pais, Abraham; Jacob, Maurice; Olive, David I.; Atiyah, Michael F.

    1998-02-01

    Preface Peter Goddard; Dirac memorial address Stephen Hawking; 1. Paul Dirac: aspects of his life and work Abraham Pais; 2. Antimatter Maurice Jacob; 3. The monopole David Olive; 4. The Dirac equation and geometry Michael F. Atiyah.

  12. Paul Dirac

    NASA Astrophysics Data System (ADS)

    Pais, Abraham; Jacob, Maurice; Olive, David I.; Atiyah, Michael F.

    2005-09-01

    Preface Peter Goddard; Dirac memorial address Stephen Hawking; 1. Paul Dirac: aspects of his life and work Abraham Pais; 2. Antimatter Maurice Jacob; 3. The monopole David Olive; 4. The Dirac equation and geometry Michael F. Atiyah.

  13. Minneapolis-Saint Paul air cargo study

    DOT National Transportation Integrated Search

    2001-12-01

    The Minneapolis-Saint Paul Task Force commissioned this study. It was established to address the apparent decline in air cargo through Minneapolis-Saint Paul airport in recent years. Distribution services, especially international air cargo, are stra...

  14. In Conversation with Paul Richards

    ERIC Educational Resources Information Center

    Holman, Andrew

    2013-01-01

    Paul Richards is one of those individuals who make a difference and is as far from institutional as one can be. The author met up with him at the Learning Disability Today conference in London to talk more about his work and life. Paul coordinates the service user involvement across Southdown Housing Association, based in Sussex.

  15. Paul G. Silver (1948-2009)

    NASA Astrophysics Data System (ADS)

    Solomon, Sean C.

    2009-11-01

    A pioneer in the novel application of seismic observations to infer the flow field of Earth's mantle and the mechanics of fault zones, Paul Gordon Silver tragically was killed on 7 August in an automobile accident that also took the life of his 22-year-old daughter, Celine. Born and raised in Los Angeles, Calif., Paul received all of his degrees from the University of California. Following receipt of a B.A. in psychology from the University of California (UC), Los Angeles (1970), he pursued a career as a musician for several years. Drawn to Earth science, Paul obtained a B.A. in geology from UC Berkeley, in 1976, and he was recruited by Tom Jordan (now at the University of Southern California) to the graduate program of the Scripps Institution of Oceanography at UC San Diego.

  16. Treatment of nasal fractures by Paul of Aegina.

    PubMed

    Skoulakis, Charalampos E; Manios, Andreas G; Theos, Evangelos A; Papadakis, Chariton E; Stavroulaki, Pelagia S

    2008-03-01

    The most exact description of the management of nasal fractures given by any physician of ancient times belongs to Paul of Aegina (AD 625-690). The goal of this article is to describe the therapeutic methods and surgical techniques used by Paul of Aegina in the treatment of nasal injuries. We studied the original Greek texts and the translation published in Venice, titled "The seven books of excellent doctor Paul of Aegina." The sixth book of his medical compendium is devoted to surgery. We identified the treatments and techniques applied to the restoration of injured noses. In this historical article we present the management of nasal fractures by Paul of Aegina. Paul of Aegina's conservative and surgical management for each form of injury was adopted by later physicians and influenced European medicine, a management surprisingly identical with the way nasal fractures are managed nowadays.

  17. Paul Erdos

    ERIC Educational Resources Information Center

    Monroe, Helen; Scott, Paul

    2004-01-01

    This article presents a brief biography of Paul Erdos, who focused on problem-solving, particularly in the areas of number theory, combinatorics and graph theory. During his life he had no property, no family and no fixed address. He buttered his first piece of bread at age 21. He never cooked, nor ever drove a car. Another mathematician, Ron…

  18. Catalytic Creativity: The Case of Linus Pauling.

    ERIC Educational Resources Information Center

    Nakamura, Jeanne; Csikszentmihalyi, Mihaly

    2001-01-01

    Illustrates how creativity is constituted by forces beyond the innovating individual, drawing examples from the career of chemist Linus Pauling that highlight the formative influence of the social field on an individual's relationship to the domain. Pauling's case reveals how variously the social field contributes to creativity, shaping the…

  19. Obituary: Paul Barr, 1955-2005

    NASA Astrophysics Data System (ADS)

    Parmar, Arvind

    2007-12-01

    Paul Barr, an extragalactic astronomer and spacecraft mission planner, died on 19 October 2005 at his home in Noordwijk, the Netherlands, at the age of 50. Although his scientific interests ranged from AGN to X-ray binaries, he will perhaps best be remembered for his mission planning skills on EXOSAT, ISO, and Integral. Many hundreds of observers have benefited from his ability to juggle seemingly impossible observing constraints and arrive at the optimum observing program. A rare talent. Barr was born in Sunderland, England, on 28 July 1995. After attending Saint Aidans Grammar School, where his father was the headmaster, he obtained his Bachelors Degree in astronomy from the University of London (June 1976) before moving to the Mullard Space Science Laboratory. There he obtained his Doctorate in X-ray astronomy in February 1980, using data from the Ariel V and Copernicus satellites. After a Post-Doctoral position at London University, where he did research into ultra-violet emission from AGN and X-ray binaries using IUE, Paul joined ESA in 1983. He worked on a wide range of missions including EXOSAT, ISO, and Integral. These observatories spanned the wavelength range from the Infra-red to the gamma-ray, giving insight into Paul's flexibility and ability to contribute in many areas. On ISO, Paul oversaw the scientific development and use of the very successful observation scheduling system — this topic became his specialty. As ISO operations became routine, he took up the challenge of space-borne gamma-ray astronomy and moved in 1997 to Integral where he worked in the Science Operation Centre (ISOC), at ESTEC in the Netherlands, as senior mission planner. He worked with the gamma-ray imager (IBIS) instrument team to ensure that operations of their instrument were properly supported by ESA and supported preparations of announcements of opportunity. In early 2005 the ISOC moved to Europe's Space Astronomy Centre (ESAC) just outside Madrid, Spain. Paul, however

  20. Paul D. Sturkie: Avian cardiac physiologist.

    PubMed

    Bello, Nicholas T; Cohick, Wendie S; McKeever, Kenneth H; Malinowski, Karyn

    2018-06-01

    Sturkie's Avian Physiology is a highly regarded textbook for the study of comparative poultry physiology. Less well known, however, is the contribution of Paul D. Sturkie (1909-2002) as a pioneer in the experimental physiology of avian species. His seminal research on the cardiovascular and hemodynamic controls of chickens and egg-laying hens had a notable impact on the poultry industry and breeding practices of farmers. The purpose of this article is to highlight the contributions and practical insights of Paul D. Sturkie to the field of poultry science.

  1. Paul Davis Restoration Information Sheet

    EPA Pesticide Factsheets

    Paul Davis Restoration (the Company) is located in Nicholasville, Kentucky. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Lexington, Kentucky.

  2. Catalytic creativity. The case of Linus Pauling.

    PubMed

    Nakamura, J; Csikszentmihalyi, M

    2001-04-01

    This article illustrates how creativity is constituted by forces beyond the innovating individual, drawing examples from the career of the eminent chemist Linus Pauling. From a systems perspective, a scientific theory or other product is creative only if the innovation gains the acceptance of a field of experts and so transforms the culture. In addition to this crucial selective function vis-à-vis the completed work, the social field can play a catalytic role, fostering productive interactions between person and domain throughout a career. Pauling's case yields examples of how variously the social field contributes to creativity, shaping the individual's standards of judgment and providing opportunities, incentives, and critical evaluation. A formidable set of strengths suited Pauling for his scientific achievements, but examination of his career qualifies the notion of a lone genius whose brilliance carries the day.

  3. Major Additions to the Linus Pauling Canon

    NASA Astrophysics Data System (ADS)

    Davenport, Derek A.

    2002-08-01

    The National Library of Medicine has also just posted a Web site on Linus Pauling in its Profiles of Science series. While by no means as rich as the various Oregon State University sites, it is well worth visiting. There are texts of various speeches (including his Nobel address), many downloadable photographs, correspondence (including a poignant letter to James Watson and Francis Crick concerning their "rival" structures for DNA), and much else besides. There is a certain irony in Linus Pauling being honored by the National Library of Medicine. Ever since his 1949 presidential address to the American Chemical Society, and perhaps earlier, Pauling had been at loggerheads, sometimes acrimoniously so, with the medical establishment. It is easy to imagine him somewhere in the timeless infinitude of the empyrean sporting his characteristic ear-to-ear grin.

  4. Rotating Saddle Paul Trap.

    ERIC Educational Resources Information Center

    Rueckner, Wolfgang; And Others

    1995-01-01

    Describes a demonstration in which a ball is placed in an unstable position on a saddle shape. The ball becomes stable when it is rotated above some threshold angular velocity. The demonstration is a mechanical analog of confining a particle in a "Paul Trap". (DDR)

  5. 75 FR 27494 - Proposed Amendment of Class E Airspace; Pauls Valley, OK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... 0182; Airspace Docket No. 10-ASW-4] Proposed Amendment of Class E Airspace; Pauls Valley, OK AGENCY... action proposes to amend Class E airspace at Pauls Valley, OK. Additional controlled airspace is necessary to accommodate new Standard Instrument Approach Procedures (SIAPs) at Pauls Valley Municipal...

  6. Colloquy to Paul Musset

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2007-12-13

    En honneur de Paul Musset il a été décidé de faire plutôt un colloque scientifique à la place d'une cérémonie. Plusieurs personnes temoignent de leurs estime et amitié pour ce physicien et ses activités

  7. 40 CFR 81.27 - Minneapolis-St. Paul Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Minneapolis-St. Paul Intrastate Air... Air Quality Control Regions § 81.27 Minneapolis-St. Paul Intrastate Air Quality Control Region. The Minneapolis-St. Paul Intrastate Air Quality Control Region (Minnesota) consists of the territorial area...

  8. 58. Photographic copy of original construction plan (St. Paul Engineer's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    58. Photographic copy of original construction plan (St. Paul Engineer's Office, Wabasha St. Bridge, Plan of Masonry, February 1899); south abutment - Wabasha Street Bridge, Spanning Mississippi River at Wabasha Street, Saint Paul, Ramsey County, MN

  9. 11. Photocopy of photograph (from St. Paul's Church) Photographer unknown ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of photograph (from St. Paul's Church) Photographer unknown 1886 'EPISCOPAL CHURCH, CORNER OF 1ST AND J ST. BENICIA' WEST AND SOUTH SIDES - St. Paul's Episcopal Church, 120 East J Street, Benicia, Solano County, CA

  10. "Between the Heavens and the Earth": Narrating the Execution of Moses Paul

    ERIC Educational Resources Information Center

    Salyer, Matt

    2012-01-01

    The 1772 execution of the Mohegan sailor Moses Paul served as the occasion for Samson Occom's popular "Sermon," reprinted in numerous editions. Recent work by Ava Chamberlain seeks to recover Paul's version of events from contemporary court records. This article argues that Paul's "firsthand" account of the case and autobiographical narrative…

  11. Paul Vallas for Sale

    ERIC Educational Resources Information Center

    Dessoff, Alan

    2012-01-01

    Veteran Superintendent Paul Vallas, who has led turnaround efforts in major urban districts in Chicago, Philadelphia and New Orleans, has started a new venture that he expects will broaden his reach and extend the reform movement. The Vallas Group, headed by Vallas, now interim superintendent of the Bridgeport (Connecticut) Public Schools, is…

  12. Linus Pauling Memorial Lectures

    Science.gov Websites

    Institute for Science, Engineering and Public Policy Home About The Institute Format/Policy Pauling Memorial Lectures Science, Engineering and Public Policy 2017-2018 Sabbatical Year Taking a Year Physics to the New Philosophy Terry Bristol Institute for Science, Engineering and Public Policy 7:00pm

  13. The great man from Tarsus: Freud on the apostle Paul.

    PubMed

    Westerink, Herman

    2007-01-01

    The author describes developments in Freud's writings concerning his views on the apostle Paul. This development shows that Freud more and more clearly regarded Paul as a key figure in understanding the complex relationship between Judaism and Christianity--and also as a man who essentially has no comfortable place in either of these religions. For Freud, Paul was a unique figure, an analyst of the human character and of his own culture and religion--a Jew who tried to free himself and his people from the burden of the sense of guilt.

  14. Meandering Musings by Linus Pauling: "American Scientists and the Spirit of the Frontier".

    PubMed

    Bause, George S

    2016-04-01

    Hoping to raise funds in 1975 for his namesake institute, Linus Pauling submitted to Esquire magazine a 32-page handwritten manuscript, "American Scientists and the Spirit of the Frontier." Angered when his submission for publication was declined, Pauling eventually gifted the original manuscript in 1986 to his friend, Linus Pauling Institute fundraiser Stephen Maddox, who would sell it in 2004 to the Wood Library-Museum of Anesthesiology. Published accurately here for the first time, the manuscript captures not only Pauling's sweeping metaphor of scientists as frontiersmen but also the creative process by which Pauling formulated his hydrate microcrystal theory of general anesthesia. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Colloquy to Paul Musset

    ScienceCinema

    None

    2017-12-09

    En honneur de Paul Musset il a été décidé de faire plutôt un colloque scientifique à la place d'une cérémonie. Plusieurs personnes temoignent de leurs estime et amitié pour ce physicien et ses activités

  16. Paul Piccone: Outside Academe

    ERIC Educational Resources Information Center

    Jacoby, Russell

    2008-01-01

    Today the academic world--open to Jews, women, and other previously excluded groups--has been completely revamped. Or has it? Despite the changes, is it possible the institution still promotes the mediocre and demotes the extraordinary? The life and work of Paul Piccone bear on this question--and others. Piccone, who died of cancer in 2004 at 64,…

  17. Paul Feyerabend: Science and the Anarchist.

    ERIC Educational Resources Information Center

    Science, 1979

    1979-01-01

    Presents comments on the arguments of Paul Feyerabend toward progression science. The positions held by this philosopher of science are given with accompanying remarks from other philosophers and historians. (SA)

  18. Tropical Cyclone Paul

    NASA Image and Video Library

    2010-03-30

    NASA image March 29, 2010 Tropical Cyclone Paul spanned the ocean waters between Australia and New Guinea on March 29, 2010. The MODIS on NASA’s Terra satellite captured this natural-color image the same day. The center of the cyclone is along the coast of Northern Territory’s Arnhem Land. Clouds run counter-clockwise across the Gulf of Carpentaria and Cape York Peninsula, over New Guinea’s Pulau Dolok, and over the Arafura Sea. On March 29, 2010, the U.S. Navy’s Joint Typhoon Warning Center (JTWC) reported that Tropical Cyclone Paul storm had maximum sustained winds of 60 knots (110 kilometers per hour) and gusts up to 75 knots (140 kilometers per hour). The storm was located roughly 315 nautical miles (585 kilometers) east of Darwin. The storm had moved slowly toward the southwest over the previous several hours. The JTWC forecast that the storm would likely maintain its current intensity for several more hours before slowly dissipating over land. Credit: NASA/GSFC/Jeff Schmaltz/MODIS To learn more about this image go to: modis.gsfc.nasa.gov/gallery/individual.php?db_date=2010-0... NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

  19. Linus Pauling's "molecular diseases": between history and memory.

    PubMed

    Strasser, Bruno J

    2002-08-30

    In 1949, Linus Pauling and his collaborators published a study in the journal Science entitled "Sickle Cell Anemia, a Molecular Disease." In this now classic study, they showed that hemoglobin from patients suffering from sickle cell anemia has a different electrical charge than hemoglobin from healthy individuals. This result demonstrated for the first time that an abnormal protein could be causally linked to a disease, and that genes determined the structure of proteins. This report made headline news and had a powerful impact on both the biomedical community and the general public. Fifty years later, this study is discussed in almost every medical and biological textbook and has became a favorite example in editorials to illustrate the progress of biomedical research. This article explores the history of Pauling's sickle cell anemia and its subsequent integration in different collective memories, up to the present day. It also discusses the function of the collective memories of Pauling's discovery for contemporary biomedical research. Copyright 2002 Wiley-Liss, Inc.

  20. 75 FR 34097 - Expansion of Foreign-Trade Zone 119; Minneapolis-St. Paul Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1684] Expansion of Foreign-Trade Zone 119; Minneapolis-St. Paul Area Pursuant to its authority under the Foreign-Trade Zones Act of June 18... Sites 7 and 8 in the Minneapolis-St. Paul area, adjacent to the Minneapolis-St. Paul Customs and Border...

  1. In Memoriam: Paul J. Lioy

    EPA Science Inventory

    Exposure Science has lost one of its founders and intellectual champions. Dr. Paul Lioy unexpectedly passed away on July 8, 2015 at the age of 68 years. The world has been left a far better place thanks to Dr. Lioy’s vision and creativity, enormous scientific contributions,...

  2. Paul D. Boyer, Adenosine Triphosphate (ATP), and the Binding Change

    Science.gov Websites

    -- October 1975, DOE Technical Report, 1975 A Perspective of the Binding Change Mechanism for ATP Synthesis Reports, Vol. 18, No. 3, 1998 ATP Synthesis and the Binding Change Mechanism: The Work of Paul D. Boyer Mechanism of ATP Synthesis Additional Web Pages: Adenosine Triphosphate: The Energy Currency of Life Paul D

  3. Paul's gospel and the rhetoric of apostolic rejection: A study of Galatians 1:15--17, 1 Corinthians 15:8, F. C. Baur, and the origins of Paul's Gentile mission

    NASA Astrophysics Data System (ADS)

    Mitchell, Matthew Wesley

    This dissertation proposes a new understanding of Paul's Gentile mission and its relationship to his so-called "conversion." This dissertation examines the origins of Paul's mission to the Gentiles, and locates it in his claims to have been personally commissioned to undertake such a mission by Jesus. Specifically, I argue that it is the rejection of Paul's claim to be an apostle, a claim founded upon his "conversion" experience, that precipitates his mission to the Gentiles. In arguing this view, I draw upon Ferdinand Christian Baur's nineteenth century theories concerning both the unreliability of Acts as a historical source, and his proposal of a clear division between Paul and the other apostles. In establishing the methodological and theoretical framework of the dissertation, I discuss the "New Perspective on Paul" that has dominated New Testament scholarship over the past thirty years. My study is also informed methodologically by the growing interest in rhetorical criticism among biblical scholars, although the emphasis of this dissertation bears more of a resemblance to the approach of the New Rhetoric than the categories of classical, Greco-Roman rhetoric. The textual component of this work falls into two stages. The first contains a full examination of Paul's "conversion passages" in Galatians 1:15--17 and 1 Corinthians 15:8, attempting to situate these seemingly unusual self-descriptions in their cultural contexts. The second involves an examination of F. C. Baur's presentation of Paul, and the reception of Baur's views among biblical scholars throughout the years following his scholarly activity. This dissertation makes two claims, each of which can stand on its own as an important contribution to scholarship. My first claim is that components of Baur's work support my proposal concerning Paul's Gentile mission and his experience of apostolic rejection, and that this proposal has much to commend it as an explanation of a perennial scholarly puzzle. My

  4. Speaking Personally--With Paul Avon

    ERIC Educational Resources Information Center

    Martin, D'Arcy

    2012-01-01

    This article presents an interview with Paul Avon, the former executive director of the Canadian Virtual College Consortium. Avon has spent over fifteen years in the distance learning (DL) field managing the production and delivery of online learning at TVOntario, Humber College, the Sri Lankan National Online Distance Education Service, and the…

  5. 77 FR 41168 - Marine Mammals; Subsistence Taking of Northern Fur Seals; St. Paul Island

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... Mammals; Subsistence Taking of Northern Fur Seals; St. Paul Island AGENCY: National Marine Fisheries... taking of northern fur seals on St. Paul Island. St. Paul's petition requests that NMFS revise the... seals; take a total of up to 3,000 fur seals annually compared to 2,000 currently allowed, including up...

  6. View of Minneapolis-St.Paul, Minnesota area

    NASA Image and Video Library

    1973-08-30

    SL3-28-009 (July-September 1973) --- A near vertical view of the Minneapolis-St. Paul, Minnesota area, as photographed from Earth orbit by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the Skylab space station. A 150mm lens, with SO-356 high definition Ektachrome film, was used to take this picture. The Mississippi River flows southeasterly through this large metropolitan area. Minneapolis is on the west bank of the Mississippi. The Minnesota River makes a large bend at the southern edge of the picture then flows northeasterly to empty into the Mississippi at Minneapolis-St. Paul. The St. Croix River, which serves as a portion of the boundary between Minnesota and Wisconsin, flows into the Mississippi downstream from the twin cities. A long, nearly straight, stretch of Interstate 35 leads southward from Minneapolis-St. Paul. Interstate 94 parallels the Mississippi toward the northwest. The highway and road network in the area is clearly visible. Note the numerous small lakes in the photograph. This view includes the smaller cities of Hastings, Faribault, Owatonna, Mankato, St. Peter, New Ulm and St. Cloud. The S190-A experiment is part of the Skylab Earth Resources Experiments Package. Photo credit: NASA

  7. [Fatal diseases and "imaginary" suffering. "Hypochondria" and "consumption" in the correspondence between Jean Paul and Johann Bernhard Hermann, with a perspective on Jean Paul's literature and aesthetics].

    PubMed

    Meier, Monika

    2007-01-01

    The German writerJean Paul (Johann Paul Friedrich Richter, 1763-1825) and his friendJohann Bernhard Hermann (1761-1790) became acquainted with the thoughts of late Enlightenment at the University of Leipzig. They particularly appreciated the anthropology of Ernst Platner, who taught philosophy and aesthetics as well as medicine. Their confidential correspondence contains reflections on their respective situation and well being. Both write about feeling ill and label their illness "hypochondria". In the course of the correspondence Jean Paul's understanding of hypochondria evolves from an illness of the entrails as he follows Hermann, who supports the modern concept of hypochondria as an illness of the nerves. Two important themes from this correspondence recur in Jean Paul's novels and tales: firstly, his way of expressing comfort is related to his aesthetics, and secondly, the satirical way of portraying at least certain aspects of illness as imaginary reappears in his first successful novel "The Invisible Lodge" (1793).

  8. In Conversation with Paul Burstow

    ERIC Educational Resources Information Center

    Holman, Andrew

    2013-01-01

    Paul Burstow, a former minister for social care, was once charged with finding savings in care services. He completed his last two years, cut the Valuing People Now programme early, and returned to the back benches. He did, however, draft a Care and Support Bill and has subsequently used this experience to chair a joint Parliamentary Scrutiny…

  9. "Paul Revere's Ride": Awakening Abolitionists

    ERIC Educational Resources Information Center

    Lepore, Jill

    2011-01-01

    Henry Wadsworth Longfellow used to be both the best-known poet in the English-speaking world and the most beloved, adored by the learned and the lowly alike, read by everyone from Nathaniel Hawthorne and Abraham Lincoln to John Ruskin and Queen Victoria--and, just as avidly, by the queen's servants. "Paul Revere's Ride" is Longfellow's best-known…

  10. Paul Carlson | Center for Cancer Research

    Cancer.gov

    Paul Carlson, Ph.D. March 28 Principal Investigator Laboratory of Mucosal Pathogens and Cellular Immunology Center for Biologics Evaluation and Research (CBER), FDA Topic:  "Research and Regulation of novel biologic products at the FDA's Center for Biologics Evaluation and Research"

  11. Line Designs Inspired by Paul Klee

    ERIC Educational Resources Information Center

    Blanchette, Lisa

    2009-01-01

    In this lesson, students learn about line, shape, color, mixed media and abstraction, while being introduced to Swiss artist, Paul Klee (1879-1940). This lesson works well with a variety of age levels and abilities and could also be used to teach analogous or triad color schemes.

  12. "Dancing Cannot Start Too Soon": Spiritual Education in the Thought of Jean Paul Friedrich Richter

    ERIC Educational Resources Information Center

    Pridmore, John

    2004-01-01

    Johann Paul Friedrich Richter (1763-1825) adopted the pen-name "Jean Paul" in honour of Jean Jaques Rousseau. His "Levana or the doctrine of education" ("Levana oder Erziehlehre") was once a standard text and required reading in teacher education. Outside Germany the name of Jean Paul is now little known and the…

  13. Classical Sax: Conversation with Paul Brodie.

    ERIC Educational Resources Information Center

    Row, David W.

    1984-01-01

    Paul Brodie, the most recorded concert saxophonist in the history of the instrument, talks about a number of topics, including his career, differences among saxophonists, mixing styles of playing, the effectiveness of music schools, and whether it is necessary to understand the structure of the piece being played. (RM)

  14. Meet EPA Ecologist Paul Mayer, Ph.D.

    EPA Pesticide Factsheets

    EPA ecologist Paul Mayer, Ph.D. works in EPA's Groundwater and Ecosystem Restoration division where he studies riparian zones (the area along rivers and streams where the habitats are influenced by both the land and water) and stream restoration

  15. Paul Zindel: Flirting with the Bizarre.

    ERIC Educational Resources Information Center

    Winarski, Diana L.

    1994-01-01

    Profiles Paul Zindel, the best-selling author of childrens' and adolescents' novels who combines hyperbole and pathos in such works as "The Pigman;""My Darling, My Hamburger;" and "The Pigman and Me." Zindel is also the author of the play "The Effect of Gamma Rays on Man-in-the-Moon Marigolds." (MDM)

  16. 76 FR 73666 - Notice of Inventory Completion: Paul H. Karshner Memorial Museum, Puyallup, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ..., 2011. ADDRESSES: Brian Fox, Director of Instructional Leadership, Puyallup School District, Paul H... criteria in 43 CFR 10.11(c)(1) should contact Brian Fox, Director of Instructional Leadership, Paul H...

  17. Multistep estimators of the between-study variance: The relationship with the Paule-Mandel estimator.

    PubMed

    van Aert, Robbie C M; Jackson, Dan

    2018-04-26

    A wide variety of estimators of the between-study variance are available in random-effects meta-analysis. Many, but not all, of these estimators are based on the method of moments. The DerSimonian-Laird estimator is widely used in applications, but the Paule-Mandel estimator is an alternative that is now recommended. Recently, DerSimonian and Kacker have developed two-step moment-based estimators of the between-study variance. We extend these two-step estimators so that multiple (more than two) steps are used. We establish the surprising result that the multistep estimator tends towards the Paule-Mandel estimator as the number of steps becomes large. Hence, the iterative scheme underlying our new multistep estimator provides a hitherto unknown relationship between two-step estimators and Paule-Mandel estimator. Our analysis suggests that two-step estimators are not necessarily distinct estimators in their own right; instead, they are quantities that are closely related to the usual iterative scheme that is used to calculate the Paule-Mandel estimate. The relationship that we establish between the multistep and Paule-Mandel estimator is another justification for the use of the latter estimator. Two-step and multistep estimators are perhaps best conceptualized as approximate Paule-Mandel estimators. © 2018 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd.

  18. Paul of Tarsus: The Ancient Model of "Parrhesia" or Freedom of Speech.

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    The word "parrhesia" is of Greek origin and indicates the right to say anything a person chooses. The Apostle Paul was himself an operational definition of parrhesia, and a term that symbolizes such a controlling force on such a significant figure is worthy of examination and academic study. For Paul, his work as an evangelist and pastor was a…

  19. The first 'molecular disease': a story of Linus Pauling, the intellectual patron.

    PubMed

    Gormley, Melinda

    2007-06-01

    In November 1949, chemist Linus Pauling and three colleagues published an article on sickle-cell anemia, a study that opened up new and exciting possibilities for research into such 'molecular diseases'. Even before this celebrated publication appeared in Science, Pauling foresaw its potential benefits and announced it as a medical breakthrough: '... our structural chemistry and understanding of molecules is getting to the point where it should be of assistance in converting medicine into a real science' [Guiles, R. (1949) Discovery of blood disease called key to cancer research. The Detroit Times 13 Sep 1949, Newspaper Clippings 1949n.18, Pauling Papers.]. Their discovery--that this debilitating disorder was caused by an abnormal form of hemoglobin--was borne out of a rich mix of expertise, from Pauling's remarkable intuition to the careful experimental chemistry of his student Harvey A. Itano. It also relied upon technological innovation: a custom-made electrophoresis machine housed at the California Institute of Technology was the perfect tool to reveal fundamental chemical differences between normal and abnormal forms of hemoglobin. Not only did this work establish a new way of looking at inherited diseases, it also stimulated the mass production of the electrophoresis machine as an essential investigative and diagnostic tool. A close inspection of this case study illustrates just how Pauling ran his laboratory and helps to explain how one man could achieve so much over his lifetime.

  20. Hermann Paul and General Linguistic Theory

    ERIC Educational Resources Information Center

    Koerner, E. F. K.

    2008-01-01

    In most history of linguistics textbooks available until today Hermann Paul and his "Principles of Historical Linguistics," first published in 1880 and still available in reprints of the fifth edition of 1920, if given any attention at all, is cited for a statement he included in the second edition of 1886 in response to a review that…

  1. Parallel Narrative Structure in Paul Harding's "Tinkers"

    ERIC Educational Resources Information Center

    Çirakli, Mustafa Zeki

    2014-01-01

    The present paper explores the implications of parallel narrative structure in Paul Harding's "Tinkers" (2009). Besides primarily recounting the two sets of parallel narratives, "Tinkers" also comprises of seemingly unrelated fragments such as excerpts from clock repair manuals and diaries. The main stories, however, told…

  2. 75 FR 67303 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM 10... proposes to determine that the Hayden, Nogales, and Paul Spur/Douglas nonattainment areas in Arizona... Hayden, Nogales and Paul Spur/Douglas nonattainment areas are not currently attaining the PM 10 standard...

  3. [From Paul Flechsig to the Paul Flechsig Institute for Brain Research. Development of brain research at the Karl Marx University].

    PubMed

    Leibnitz, L; Werner, L; Schober, W; Brauer, K

    1977-04-01

    A review is given on the development of the brain research institute of the Karl-Marx-University of Leipzig during the directorates of Paul Flechsig (1883-1920), Richard Arwed Pfeifer (1925-1957), and Wolfgang Wünscher (1957-1971).

  4. Les instabilités antérieures de l’épaule:à propos de 73 cas

    PubMed Central

    Jamal, Louaste; Bousbaa, Hicham; Cherrad, Taoufik; Wahidi, Mohammed; Amhajji, Larbi; Rachid, Khalid

    2016-01-01

    Entre 2005 et 2014, 73patients (77 épaules) ont bénéficié d’une intervention de Latarjet pour instabilité antérieure de l’épaule. Nous avons, rétrospectivement, évalué les résultats cliniques et radiologiques de cette technique opératoire. L’intervention a été réalisée pour le traitement d’une luxation récidivante dans 69 cas, subluxation récidivante douloureuse dans 5 cas et 3 épaules douloureuses Tous les patients ont eu une évaluation radiographique avant l’intervention et lors du contrôle le plus récent. Selon le score de Rowe, 73 (94.8 %) des 77 épaules ont obtenu un résultat bon ou excellent. Au plus grand recul, 74 épaules étaient indemnes d’arthrose glénohumérale. PMID:27800066

  5. Paul Langerhans: a prilgrim "traveling" from functional histology to marine biology.

    PubMed

    Raica, Marius; Cimpean, Anca Maria

    2017-06-01

    The nineteenth century was the time of a real revolution in science and medicine. A lot of seminal discoveries in medicine and biology were done in this time, and many of them were coincident with the introduction of the compound microscope by Hermann van Deijl and the standard histological technique by Paul Ehrlich. The main tissue types and individual cells were characterized and originally classified more than hundred years ago, although less attention was paid to their basic functions. This was mainly due to the modality of tissue specimen processing that allowed particularly detailed descriptive studies. Even so, we can notice some attempts to correlate the structure with the function. The German scientist Paul Langerhans, well-known for the discovery of Langerhans islets of the pancreas and Langerhans cells from the epidermis, tried to change the conventional fate of morphological studies introducing in his works functional hypothesis based on traditional microscopic observations even from the beginning of his scientific career. Paul Langerhans was a complex personality of the second half of the nineteenth century, not only in medicine, but also in other fields of biology. In the present review, presented is the life and research activity of Paul Langerhans, not only because of the importance of his discoveries, but also for perspectives that were opened by these findings in unexpected fields of medicine and biology.

  6. Brotherly Advice: Letters from Hugo to Paul Ehrenfest in his Final Years

    NASA Astrophysics Data System (ADS)

    Halpern, Paul

    2006-03-01

    At the start of the 1930s, theoretician Paul Ehrenfest spent much of his time traveling through America and Europe while engaged in a steady stream of lectures. This traveling phase coincided with a frantic and intense period of negative self-examination, financial difficulty, and various other personal concerns that would ultimately lead to his 1933 suicide. Throughout these final years, he kept up a steady correspondence with his brother Hugo, a physician based in Saint Louis. Ten years older than Paul, Hugo freely doled out frank psychological advice about subjects ranging from the proper treatment of children to the dangers of self-pity. Through a look at some of the letters exchanged between the two brothers, this talk will examine the role Hugo played during the dark final years of Paul Ehrenfest's life.

  7. Vitamin C supplementation and the common cold--was Linus Pauling right or wrong?

    PubMed

    Hemilä, H

    1997-01-01

    In 1970 Linus Pauling claimed that vitamin C prevents and alleviates the episodes of the common cold. Pauling was correct in concluding from trials published up till then, that in general vitamin C does have biological effects on the common cold, but he was rather over-optimistic as regards the size of benefit. His quantitative conclusions were based on a single placebo-controlled trial on schoolchildren in a skiing camp in the Swiss Alps, in which a significant decrease in common cold incidence and duration in the group administered 1 g/day of vitamin C was found. As children in a skiing camp are not a representative sample of the general population, Pauling's extrapolation to the population at large was too bold, erring as to the magnitude of the effect. Nevertheless, Pauling's general conclusion that vitamin C has physiological effects on the common cold is of major importance as it conflicts with the prevailing consensus that the only physiological effect of vitamin C on human beings is to prevent scurvy.

  8. RadNet Air Data From St. Paul, MN

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for St. Paul, MN from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  9. Paul trapping of charged particles in aqueous solution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guan, Weihau; Reed, Mark A; Joseph, Sony nmn

    2011-01-01

    We experimentally demonstrate the feasibility of an aqueous Paul trap using a proof-of-principle planar device. Radio frequency voltages are used to generate an alternating focusing/defocusing potential well in two orthogonal directions. Individual charged particles are dynamically confined into nanometer scale in space. Compared with conventional Paul traps working in frictionless vacuum, the aqueous environment associated with damping forces and thermally induced fluctuations (Brownian noise) exerts a fundamental influence on the underlying physics. We investigate the impact of these two effects on the confining dynamics, with the aim to reduce the rms value of the positional fluctuations. We find that themore » rms fluctuations can be modulated by adjusting the voltages and frequencies. This technique provides an alternative for the localization and control of charged particles in an aqueous environment.« less

  10. Paul Voosen Receives 2013 David Perlman Award for Excellence in Science Journalism—News: Citation

    NASA Astrophysics Data System (ADS)

    Zaneski, Cyril T.

    2014-01-01

    It's my pleasure to nominate Paul Voosen, the former science reporter for Greenwire, for the David Perlman award. Last November, as Superstorm Sandy pounded the East Coast of the United States, Paul found himself stranded for several days in Miami, mourning a recently deceased family member.

  11. Paul Lampe/McGarry Houghton | Division of Cancer Prevention

    Cancer.gov

    Project Title/Research Areas: Hybrid Plasma Markers that Complement CT Imaging for Early Lung Cancer DetectionPrincipal Investigator/Institution:  Paul Lampe/McGarry Houghton, Fred Hutchinson Cancer Research Center |

  12. 78 FR 46938 - St. Paul Park Refining Co. LLC v. Enbridge Pipelines (North Dakota) LLC; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. OR13-28-000] St. Paul Park..., 2013, St. Paul Park Refining Co. LLC (Complainant) filed a formal complaint against Enbridge Pipelines... regulatory basis. St. Paul Park Refining Co. LLC certifies that copies of the complaint were served on the...

  13. Hammett equation and generalized Pauling's electronegativity equation.

    PubMed

    Liu, Lei; Fu, Yao; Liu, Rui; Li, Rui-Qiong; Guo, Qing-Xiang

    2004-01-01

    Substituent interaction energy (SIE) was defined as the energy change of the isodesmic reaction X-spacer-Y + H-spacer-H --> X-spacer-H + H-spacer-Y. It was found that this SIE followed a simple equation, SIE(X,Y) = -ksigma(X)sigma(Y), where k was a constant dependent on the system and sigma was a certain scale of electronic substituent constant. It was demonstrated that the equation was applicable to disubstituted bicyclo[2.2.2]octanes, benzenes, ethylenes, butadienes, and hexatrienes. It was also demonstrated that Hammett's equation was a derivative form of the above equation. Furthermore, it was found that when spacer = nil the above equation was mathematically the same as Pauling's electronegativity equation. Thus it was shown that Hammett's equation was a derivative form of the generalized Pauling's electronegativity equation and that a generalized Pauling's electronegativity equation could be utilized for diverse X-spacer-Y systems. In addition, the total electronic substituent effects were successfully separated into field/inductive and resonance effects in the equation SIE(X,Y) = -k(1)F(X)F(Y) - k(2)R(X)R(Y) - k(3)(F(X)R(Y) + R(X)F(Y)). The existence of the cross term (i.e., F(X)R(Y) and R(X)F(Y)) suggested that the field/inductive effect was not orthogonal to the resonance effect because the field/inductive effect from one substituent interacted with the resonance effect from the other. Further studies on multi-substituted systems suggested that the electronic substituent effects should be pairwise and additive. Hence, the SIE in a multi-substituted system could be described using the equation SIE(X1, X2, ..., Xn) = Sigma(n-1)(i=1)Sigma(n)(j=i+1)k(ij)sigma(X)isigma(X)j.

  14. Paul W. Kruse (1927-2012), In Memoriam

    NASA Astrophysics Data System (ADS)

    Reine, Marion B.; Norton, Paul R.; Stelzer, Ernie L.

    2013-06-01

    During his distinguished 37-year career as a research physicist at the Honeywell Research Center in Minneapolis, Minnesota, Dr. Paul W. Kruse (1927-2012) played leadership roles in two disruptive infrared detector technologies, the narrow-gap semiconductor alloy HgCdTe and the silicon CMOS-based microbolometer array, both of which revolutionized the worldwide infrared detector industry. He served on numerous government advisory boards and panels, including the Army Scientific Advisory Panel and the Army Science Board, for which he received the Outstanding Civilian Service Medal. After retiring for Honeywell in 1993, he remained active in the infrared detector field in several roles: as a successful small-business entrepreneur, as an author of two books, and as a SPIE lecturer. His books, papers and lectures have educated new generations of workers in the infrared detector industry. His career, a model for industrial research physicists, has had major and permanent impacts on the worldwide infrared detector industry. This paper is a summary of the career of Paul W. Kruse, as well as a tribute to that career and its lasting legacy.

  15. Staphylokinase has distinct modes of interaction with antimicrobial peptides, modulating its plasminogen-activation properties

    PubMed Central

    Nguyen, Leonard T.; Vogel, Hans J.

    2016-01-01

    Staphylokinase (Sak) is a plasminogen activator protein that is secreted by many Staphylococcus aureus strains. Sak also offers protection by binding and inhibiting specific antimicrobial peptides (AMPs). Here, we evaluate Sak as a more general interaction partner for AMPs. Studies with melittin, mCRAMP, tritrpticin and bovine lactoferricin indicate that the truncation of the first ten residues of Sak (SakΔN10), which occurs in vivo and uncovers important residues in a bulge region, improves its affinity for AMPs. Melittin and mCRAMP have a lower affinity for SakΔN10, and in docking studies, they bind to the N-terminal segment and bulge region of SakΔN10. By comparison, lactoferricin and tritrpticin form moderately high affinity 1:1 complexes with SakΔN10 and their cationic residues form several electrostatic interactions with the protein’s α-helix. Overall, our work identifies two distinct AMP binding surfaces on SakΔN10 whose occupation would lead to either inhibition or promotion of its plasminogen activating properties. PMID:27554435

  16. Paul Laurence Dunbar: Dialect et la Negritude

    ERIC Educational Resources Information Center

    Hudson, Gossie Harold

    1973-01-01

    The black poet Paul Laurence Dunbar, born June 27, 1872 and died February 9, 1906, was an unrivalled forerunner of the great literary generation of his race that burst forth after the first World War and founded the Black Renaissance; the concept of La Negritude'' developed principally among poets of African descent before World War 2. (Author/JM)

  17. Publications - GMC 61 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    Slope wells: ARCO Oliktok Pt. #1; ARCO West Sak R. St. #1; ARCO West Sak #25; ARCO West Sak #24; Exxon Alaska St. A-1; Conoco Milne Pt. A-2; Conoco Milne Pt. B-3; Conoco Milne Pt. C-3 Authors: Minder, Michael from the following 8 North Slope wells: ARCO Oliktok Pt. #1; ARCO West Sak R. St. #1; ARCO West Sak #25

  18. Route-Specific Transit Marketing in Minneapolis/St. Paul, MN

    DOT National Transportation Integrated Search

    1985-10-01

    The Minneapolis/St. Paul Transit Marketing Demonstration involved the administration of a combination of marketing techniques on five selected transit routes. The approach employed differed from most previous marketing demonstrations in that 1) prici...

  19. 78 FR 76143 - Proposed CERCLA Settlement Relating to the Paul's Tank Cleaning Service Superfund Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Paul's Tank Cleaning Service Superfund Site, Burlington County, New Jersey AGENCY: Environmental.... (``Settling Party''). The Settling Party is a potentially responsible party, pursuant to Section 107(a) of CERCLA, and thus is potentially liable for response costs incurred at or in connection Paul's Tank...

  20. A Response to Paul Stapleton's "Critiquing Research Methodology"

    ERIC Educational Resources Information Center

    Ross, Steven J.

    2006-01-01

    Paul Stapleton's (2006) critique of quantitative research brings to the surface some common interpretive problems arising when experimental and quasi-experimental research designs are compared. While Stapleton may be correct in pointing out the superiority of experimental research designs because they best eliminate the influence of extraneous…

  1. Asymptotic solution of Fokker-Planck equation for plasma in Paul traps

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shah, Kushal

    2010-05-15

    An exact analytic solution of the Vlasov equation for the plasma distribution in a Paul trap is known to be a Maxwellian and thus, immune to collisions under the assumption of infinitely fast relaxation [K. Shah and H. S. Ramachandran, Phys. Plasmas 15, 062303 (2008)]. In this paper, it is shown that even for a more realistic situation of finite time relaxation, solutions of the Fokker-Planck equation lead to an equilibrium solution of the form of a Maxwellian with oscillatory temperature. This shows that the rf heating observed in Paul traps cannot be caused due to collisional effects alone.

  2. Paul Pintrich: A Once and Continuing Influence

    ERIC Educational Resources Information Center

    Maehr, Martin L.

    2005-01-01

    This article provides an integrative perspective on the articles presented in this special issue. It is also a very personal perspective. In such small space it is impossible to do justice fully to Paul's work or to the reflections on that work. What this final article attempts is a statement that emphasizes the scope and depth of this work as…

  3. Headache classification and the Bible: Was St Paul's thorn in the flesh migraine?

    PubMed

    Göbel, H; Isler, H; Hasenfratz, H P

    1995-06-01

    The conversion of Saul to Paul was a major event in the history of Western culture. Compared with its impact, any medical comments may seem redundant, but they have kept their place in the literature for many centuries. The flashing light that caused Saul to fall is often explained as solar retinopathy or keratitis, a seizure, or even a hysterical fit. These interpretations propose either a trivial injury or disease that would interfere with mental health. Neither version is quite compatible with the dramatic dimension of the event and with Paul's later achievements and sufferings. In later years, Paul became a great manager, preacher and writer who was able to carry on under any kind of duress, though not without very painful reactions. He was suffering from bouts of unilateral headache, and also from a chronic eye condition which gave great trouble to his followers but did not cause lasting damage; the descriptions fulfil the criteria for migraine without aura of the 1988 Headache Classification. If the flashing light that caused Paul to fall down is interpreted as a visual migraine aura, with the additional symptoms of "not seeing" or photophobia and anorexia, it falls into place with his later history of migraine.

  4. Paul Oil Company, Inc. Consent Agreements and Proposed Final Orders

    EPA Pesticide Factsheets

    Proposed settlements, recorded in two Consent Agreements and Final Orders (“Proposed Consent Agreements”), between EPA and Paul Oil Company, Inc., to resolve two civil administrative penalty proceedings.

  5. 5. Historic American Buildings Survey Paul J. F. Schumacher, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Paul J. F. Schumacher, Photographer September 1957 FRONT and WEST SIDE ELEVATIONS - Sacred Heart Mission, Interstate 90 & Interchange 39, Cataldo, Shoshone County, ID

  6. k and q Dedicated to Paul Callaghan

    NASA Astrophysics Data System (ADS)

    Blümich, Bernhard

    2016-06-01

    The symbols k and q denote wave numbers in scattering experiments as well as in NMR imaging. Their exploration in NMR is intimately linked to the legacy of Paul Callaghan with his books Magnetic Resonance Microscopy and Translational Dynamics & Magnetic Resonance (Oxford University Press, Oxford 1991 and 2011) placing their focus with their titles on k and q, respectively. Some aspects of k and q have been revisited in the Paul Callaghan lecture of the author at the ISMAR Conference in Shanghai in 2015, which are reviewed here. In particular, there are two definitions of q, one relating to diffusive displacement (q) and the other to coherent flow (qv). Concerning the latter, it turns out, that in the short gradient pulse limit, the common anti-phase pulsed field-gradient scheme can be replaced with schemes employing three and more gradient pulses, which derive from differentiation rules in numerical analysis. Practical gradient modulation schemes with finite gradient pulse widths follow from these to measure velocity with improved accuracy. This approach can be expanded to acceleration and higher order transport coefficients with applications to measurements of flow and potentially also restricted diffusion.

  7. Surface-electrode point Paul trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Tony Hyun; Herskind, Peter F.; Chuang, Isaac L.

    2010-10-15

    We present a model as well as experimental results for a surface electrode radiofrequency Paul trap that has a circular electrode geometry well suited for trapping single ions and two-dimensional planar ion crystals. The trap design is compatible with microfabrication and offers a simple method by which the height of the trapped ions above the surface may be changed in situ. We demonstrate trapping of single {sup 88}Sr{sup +} ions over an ion height range of 200-1000 {mu}m for several hours under Doppler laser cooling and use these to characterize the trap, finding good agreement with our model.

  8. Case Report on the Illness of Paul Klee (1879–1940)

    PubMed Central

    Suter, Hans

    2014-01-01

    This article reports on the disease that afflicted Paul Klee, the famous artist. He died before the disease that killed him could be properly diagnosed. There was some conjecture afterwards that he may have suffered from scleroderma. The thorough and diligent research the author of this article has carried out over many years allows him to argue that Paul Klee was suffering from this autoimmune disease since 1935. With a degree of probability that borders on certainty, it seems that the artist suffered from ‘diffuse systemic sclerosis’, and it is from this, the most severe form of the rare autoimmune disease, that he died in 1940. PMID:24876831

  9. Paul Pinsky, PhD | Division of Cancer Prevention

    Cancer.gov

    Dr. Paul Pinsky is the chief of the Early Detection Research Branch. He has a background in statistics, epidemiology and mathematical modeling. He has worked extensively with data from the Branch's two large screening trials, the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the National Lung Screening Trial (NLST). |

  10. Paul Mills Ireland III Portrait of a Soldier

    ERIC Educational Resources Information Center

    Dolan, John P.

    2013-01-01

    This dissertation explores the life and identity of Paul Mills Ireland, III. The qualitative study was conducted using the portraiture approach and was further developed by incorporating the holistic content approach of analysis in narrative research. This fifth generation soldier was the product of a strong military lineage, most of whom were…

  11. Introduction: Reappraising Paul Feyerabend.

    PubMed

    Brown, Matthew J; Kidd, Ian James

    2016-06-01

    This volume is devoted to a reappraisal of the philosophy of Paul Feyerabend. It has four aims. The first is to reassess his already well-known work from the 1960s and 1970s in light of contemporary developments in the history and philosophy of science. The second is to explore themes in his neglected later work, including recently published and previously unavailable writings. The third is to assess the contributions that Feyerabend can make to contemporary debate, on topics such as perspectivism, realism, and political philosophy of science. The fourth and final aim is to reconsider Feyerabend's place within the history of philosophy of science in the light of new scholarship. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. 75 FR 77899 - Notice of Inventory Completion: Minnesota Indian Affairs Council, St. Paul and Bemidji, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... DEPARTMENT OF THE INTERIOR National Park Service [2253-665] Notice of Inventory Completion: Minnesota Indian Affairs Council, St. Paul and Bemidji, MN AGENCY: National Park Service, Interior. ACTION... funerary objects in the possession of the Minnesota Indian Affairs Council, St. Paul and Bemidji, MN. The...

  13. 78 FR 29612 - Prevailing Rate Systems; Redefinition of the Minneapolis-St. Paul, MN, and Southwestern Wisconsin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ... OFFICE OF PERSONNEL MANAGEMENT 5 CFR Part 532 RIN 3206-AM75 Prevailing Rate Systems; Redefinition of the Minneapolis-St. Paul, MN, and Southwestern Wisconsin Appropriated Fund Federal Wage System.... Paul, MN, and Southwestern Wisconsin appropriated fund Federal Wage System (FWS) wage areas. The final...

  14. Dipole Excitation With A Paul Ion Trap Mass Spectrometer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    MacAskill, J. A.; Madzunkov, S. M.; Chutjian, A.

    Preliminary results are presented for the use of an auxiliary radiofrequency (rf) excitation voltage in combination with a high purity, high voltage rf generator to perform dipole excitation within a high precision Paul ion trap. These results show the effects of the excitation frequency over a continuous frequency range on the resultant mass spectra from the Paul trap with particular emphasis on ion ejection times, ion signal intensity, and peak shapes. Ion ejection times are found to decrease continuously with variations in dipole frequency about several resonant values and show remarkable symmetries. Signal intensities vary in a complex fashion withmore » numerous resonant features and are driven to zero at specific frequency values. Observed intensity variations depict dipole excitations that target ions of all masses as well as individual masses. Substantial increases in mass resolution are obtained with resolving powers for nitrogen increasing from 114 to 325.« less

  15. Justice John Paul Stevens and the Erotic Boomerang.

    ERIC Educational Resources Information Center

    Lieberman, Marc

    Justice John Paul Stevens of the United States Supreme Court has ruled on obscenity cases in seven instances since his appointment. His rulings reveal that he regards obscenity as a nuisance rather than as a danger threatening to undermine the nation's morality, that he supports a nationwide standard to adjudicate obscenity cases, and that he…

  16. American Indian Capacity Building in St. Paul, Minnesota.

    ERIC Educational Resources Information Center

    Eubanks, Don

    A 1996 research project in St. Paul, Minnesota, found high rates of poverty and unemployment in its American Indian population and a lack of connection between social service agencies and the Indian community. A follow-up project aimed to support the Indian community in identifying its own priorities for research and action. Eight focus groups…

  17. How Energy Efficiency is Adding Jobs in St. Paul, Minnesota

    ScienceCinema

    Hannigan, Jim; Coleman, Chris; Oliver, LeAnn; Jambois, Louis

    2018-02-07

    Saint Paul, Minnesota is using an energy efficiency grant to provide commercial retrofits that will allow a local produce distribution company to dramatically reduce its energy costs and add dozens of new workers.

  18. How Energy Efficiency is Adding Jobs in St. Paul, Minnesota

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hannigan, Jim; Coleman, Chris; Oliver, LeAnn

    2011-01-01

    Saint Paul, Minnesota is using an energy efficiency grant to provide commercial retrofits that will allow a local produce distribution company to dramatically reduce its energy costs and add dozens of new workers.

  19. 11. Photocopy of 1906 photograph. Glass negative in Paul A. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of 1906 photograph. Glass negative in Paul A. Kohl's office, Missouri Botanical Garden. CLOSE VIEW OF LINNAEUS BUST - Missouri Botanical Garden, Linnaean House, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

  20. Microfabricated linear Paul-Straubel ion trap

    DOEpatents

    Mangan, Michael A [Albuquerque, NM; Blain, Matthew G [Albuquerque, NM; Tigges, Chris P [Albuquerque, NM; Linker, Kevin L [Albuquerque, NM

    2011-04-19

    An array of microfabricated linear Paul-Straubel ion traps can be used for mass spectrometric applications. Each ion trap comprises two parallel inner RF electrodes and two parallel outer DC control electrodes symmetric about a central trap axis and suspended over an opening in a substrate. Neighboring ion traps in the array can share a common outer DC control electrode. The ions confined transversely by an RF quadrupole electric field potential well on the ion trap axis. The array can trap a wide array of ions.

  1. 76 FR 34649 - Foreign-Trade Zone 119-Minneapolis-St. Paul, MN; Application for Reorganization Under Alternative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ...--Minneapolis-St. Paul, MN; Application for Reorganization Under Alternative Site Framework An application has... current zone project includes the following sites: Site 1 (3,002 acres)--located at the Minneapolis-St...); Site 9 (20 acres)--1700 Wynne Avenue, St. Paul (Ramsey County); and, Site 10 (236 acres)-- Bloomington...

  2. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-59) - Chehalis Covington/ Raver Paul / Paul Alston

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tippetts, Greg

    2002-04-19

    Vegetation Management along the Chehalis Covington/ Raver Paul / Paul Alston 230 and 500 kV Transmission line Corridor ROW 48/2 to 70/6 and 1/1 to 13/4. The proposed work will be accomplished in the indicated sections of the transmission line corridor with a corridor width of 250 to 442 feet. BPA proposes to clear unwanted vegetation in the rights-of-ways and around tower structures that may impede the operation and maintenance of the subject transmission lines and access roads, including Reclaim and Danger Trees. BPA plans to conduct vegetation control with the goal of removing tall growing vegetation that is currentlymore » or will soon be a hazard to the transmission line. BPA’s overall goal is to have low-growing plant communities along the rights-of-way to control the development of potentially threatening vegetation. All work will be executed in accordance with the National Electrical Safety Code and BPA standards. Danger and “C” trees and chemical treatment contract work is scheduled to begin April 29, 2002.« less

  3. 2010-2012 Minneapolis - St. Paul Travel Behavior Inventory |

    Science.gov Websites

    -St. Paul area conducted the survey. Methodology The TBI consists of a paper-based survey and a wearable global positioning system (GPS) survey. The data-collection process for these two surveys was independent, and the results are not intended to function together. Survey Records Survey records include

  4. The Initial Shock: A Conversation with Paul Fussell.

    ERIC Educational Resources Information Center

    Hackney, Sheldon

    1996-01-01

    Presents an interview with Paul Fussell, author of "The Great War and Modern Memory." Fussell speaks about the destruction of that war and his own experiences as a combat officer in World War II. He also addresses his original field of study, 18th century literature, and some of the changes wrought by the 20th century. (MJP)

  5. Paul Hill d/b/a Alternative Energy Windows and Siding

    EPA Pesticide Factsheets

    Paul Hill d/b/a Alternative Energy Windows and Siding (the Company) is located in Concord, New Hampshire. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Concord, New Hampshire.

  6. 12. Photocopy of 1906 photograph. Glass negative in Paul A. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of 1906 photograph. Glass negative in Paul A. Kohl's office, Missouri Botanical Garden. BUST OF ASA GRAY AT SOUTH ENTRANCE - Missouri Botanical Garden, Linnaean House, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

  7. 13. Photocopy of 1906 photograph. Glass negative in Paul A. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of 1906 photograph. Glass negative in Paul A. Kohl's office, Missouri Botanical Garden. BUST OF THOMAS NUTTALL AT SOUTH ENTRANCE - Missouri Botanical Garden, Linnaean House, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

  8. Revised Mulliken Electronegativities I. Calculation and Conversion to Pauling Units.

    ERIC Educational Resources Information Center

    Bratsch, Steven G.

    1988-01-01

    Discusses a revision and extension of the Mulliken electronegativity scale to consider 50 elements. Describes the calculation of valence-state promotion energies and Mulliken atomic electronegativities and the conversion of Mulliken electronegativities to Pauling units. (CW)

  9. Timing and causes of mid-Holocene mammoth extinction on St. Paul Island, Alaska

    PubMed Central

    Graham, Russell W.; Belmecheri, Soumaya; Choy, Kyungcheol; Culleton, Brendan J.; Davies, Lauren J.; Hritz, Carrie; Kapp, Joshua D.; Newsom, Lee A.; Rawcliffe, Ruth; Saulnier-Talbot, Émilie; Wang, Yue; Williams, John W.; Wooller, Matthew J.

    2016-01-01

    Relict woolly mammoth (Mammuthus primigenius) populations survived on several small Beringian islands for thousands of years after mainland populations went extinct. Here we present multiproxy paleoenvironmental records to investigate the timing, causes, and consequences of mammoth disappearance from St. Paul Island, Alaska. Five independent indicators of extinction show that mammoths survived on St. Paul until 5,600 ± 100 y ago. Vegetation composition remained stable during the extinction window, and there is no evidence of human presence on the island before 1787 CE, suggesting that these factors were not extinction drivers. Instead, the extinction coincided with declining freshwater resources and drier climates between 7,850 and 5,600 y ago, as inferred from sedimentary magnetic susceptibility, oxygen isotopes, and diatom and cladoceran assemblages in a sediment core from a freshwater lake on the island, and stable nitrogen isotopes from mammoth remains. Contrary to other extinction models for the St. Paul mammoth population, this evidence indicates that this mammoth population died out because of the synergistic effects of shrinking island area and freshwater scarcity caused by rising sea levels and regional climate change. Degradation of water quality by intensified mammoth activity around the lake likely exacerbated the situation. The St. Paul mammoth demise is now one of the best-dated prehistoric extinctions, highlighting freshwater limitation as an overlooked extinction driver and underscoring the vulnerability of small island populations to environmental change, even in the absence of human influence. PMID:27482085

  10. Paul Winter, Sun Singer...He Talks about Outdoor Education.

    ERIC Educational Resources Information Center

    Breslav, Marc

    1984-01-01

    Interviews Paul Winter, well-known musical emissary for the Earth and its wildlife among the environmental community. Incorporating voices of wolves, whales, and other creatures as accompanists to an uncategorizable blend of symphonic, jazz, African and Latin musical traditions, Winter's sound involves listeners in a guided experience of…

  11. St. Paul central corridor study : Pierce Butler industrial redevelopment parkway

    DOT National Transportation Integrated Search

    2003-07-01

    At present, development in the St. Paul Central Corridor is occurring piecemeal and lacks an integrative vision. This study's aim was to devise design approaches that create a district which integrates light industrial job creation and retention with...

  12. Stable Trapping of Multielectron Helium Bubbles in a Paul Trap

    NASA Astrophysics Data System (ADS)

    Joseph, E. M.; Vadakkumbatt, V.; Pal, A.; Ghosh, A.

    2017-06-01

    In a recent experiment, we have used a linear Paul trap to store and study multielectron bubbles (MEBs) in liquid helium. MEBs have a charge-to-mass ratio (between 10^{-4} and 10^{-2} C/kg) which is several orders of magnitude smaller than ions (between 10^6 and 10^8 C/kg) studied in traditional ion traps. In addition, MEBs experience significant drag force while moving through the liquid. As a result, the experimental parameters for stable trapping of MEBs, such as magnitude and frequency of the applied electric fields, are very different from those used in typical ion trap experiments. The purpose of this paper is to model the motion of MEBs inside a linear Paul trap in liquid helium, determine the range of working parameters of the trap, and compare the results with experiments.

  13. 27. Photocopy of August 25, 1921 photograph by Paul A. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Photocopy of August 25, 1921 photograph by Paul A. Kohl. Glass Negative Box IX, Tower Grove, Missouri Botanical Garden. ITALIAN GARDEN BY JOHN NOYES, LOOKING WEST - Missouri Botanical Garden, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

  14. 44. Photograph of original sketch by Paul Cloyd, Historical Architect, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    44. Photograph of original sketch by Paul Cloyd, Historical Architect, Denver Service Center, National Park Service, Denver, Colorado, dated March 1985. EVOLUTION OF GRAND CANYON WATER RECLAMATION PLANT AS IT STANDS TODAY. - Water Reclamation Plant, Grand Canyon, Coconino County, AZ

  15. 28. Photocopy of August 25, 1921 photograph by Paul A, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Photocopy of August 25, 1921 photograph by Paul A, Kohl. Glass Negative Box IX, Tower Grove, Missouri Botanical Garden. ITALIAN GARDEN AND FLORAL DISPLAY HOUSE, LOOKING NORTH - Missouri Botanical Garden, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

  16. Carbon Cycle 2.0: Paul Alivisatos: Introduction

    ScienceCinema

    Paul Alivisatos

    2017-12-09

    Berkeley Lab Director Paul Alivisatos speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 1, 2010. Humanity emits more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences.Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  17. Designing of a Quadrupole Paul Ion Trap

    NASA Astrophysics Data System (ADS)

    Kiyani, Abouzar; Abdollahzadeh, M.; Sadat Kiai, S. M.; Zirak, A. R.

    2011-08-01

    The ion motion equation in a Paul ion trap known as Mathieu differential equation has been solved for the first time by using Runge-Kutta methods with 4th, 6th, and 8th orders. The first stability regions in az - qz plane and the corresponding qmax values were determined and compared. Also, the first stability regions of , , , ions in the Vdc - Vac plane were drown, and the threshold voltages for the ion separation was investigated.

  18. Carbon Cycle 2.0: Paul Alivisatos: Introduction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Paul Alivisatos

    2010-02-09

    Berkeley Lab Director Paul Alivisatos speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 1, 2010. Humanity emits more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences.Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  19. JAFCO d/b/a Paul Davis Restoration and Remodeling Information Sheet

    EPA Pesticide Factsheets

    JAFCO d/b/a Paul Davis Restoration and Remodeling (the Company) is located in Memphis, Tennessee. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Memphis, Tennessee.

  20. The research contributions of Dr. Paul Van Deusen

    Treesearch

    Thomas B. Lynch; Francis A. Roesch; John Paul McTague; Jeffrey H. Gove; Gregory A. Reams; Aaron R. Weiskittel

    2015-01-01

    Dr. Paul Van Deusen’s recent passing concluded a rich 30+-year research career dedicated to development and implementation of quantitative methods for forestry and natural resources. Since the early part of his career as a biometrician with the USDA Forest Service Southern Research Station in the 1980s-1990s and continuing with his later employment at NCASI, Dr. Van...

  1. Charged particle capturing in air flow by linear Paul trap

    NASA Astrophysics Data System (ADS)

    Lapitsky, D. S.; Filinov, V. S.; Vladimirov, V. I.; Syrovatka, R. A.; Vasilyak, L. M.; Pecherkin, V. Ya; Deputatova, L. V.

    2018-01-01

    The paper presents the simulation results of micro- and nanoparticle capturing in an air flows by linear Paul traps in assumption that particles gain their charges in corona discharge, its electric field strength is restricted by Paschen equation and spherical shape of particles.

  2. SEDIMENT DATA - ST. PAUL WATERWAY - TACOMA, WA - 1996 MONITORING DATA

    EPA Science Inventory

    Benthic Infauna Monitoring Data Files are Excel-format spreadsheet files which contain data presented in the St. Paul Waterway Area Remedial Action and Habitat Restoration Project, 1996 Monitoring Report. The files can be viewed directly or readily downlo aded and read into most ...

  3. 75 FR 72964 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [R09-OAR-2010-0718; FRL-9233-1] Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM10 Nonattainment... November 2, 2010 (75 FR 67220), direct final rule determining that the Hayden, Nogales, and Paul Spur...

  4. Publications - GMC 421 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    #2K-10, Kavearak Pt. #32-25, Long Island #1, NW Eileen St. #1, Sak River #1, W. Sak River St. #1 , Socal #33-29E, and W. Kuparuk St. #3-11-11 wells Authors: ConocoPhillips Publication Date: Dec 2013 -10, Kavearak Pt. #32-25, Long Island #1, NW Eileen St. #1, Sak River #1, W. Sak River St. #1, Socal

  5. Privilege: The Making of an Adolescent Elite at St. Paul's School. Princeton Studies in Cultural Sociology

    ERIC Educational Resources Information Center

    Khan, Shamus Rahman

    2012-01-01

    As one of the most prestigious high schools in the nation, St. Paul's School in Concord, New Hampshire, has long been the exclusive domain of America's wealthiest sons. But times have changed. Today, a new elite of boys and girls is being molded at St. Paul's, one that reflects the hope of openness but also the persistence of inequality. In…

  6. Neuroscience of water molecules: a salute to professor Linus Carl Pauling.

    PubMed

    Nakada, Tsutomu

    2009-04-01

    More than 35 years ago double Nobel laureate Linus Carl Pauling published a powerful model of the molecular mechanism of general anesthesia, generally referred to as the hydrate-microcrystal (aqueous-phase) theory. This hypothesis, based on the molecular behavior of water molecules, did not receive serious attention during Pauling's life time, when scientific tools for examining complex systems such as the brain were still in their infancy. The situation has since drastically changed, and, now, in the twenty first century, many scientific tools are available for examining different types of complex systems. The discovery of aquaporin-4, a subtype of water channel abundantly expressed in glial systems, further highlighted the concept that the dynamics of water molecules in the cerebral cortex play an important role in important physiological brain functions including consciousness and information processing.

  7. Improving Success in Developmental Mathematics: An Interview with Paul Nolting

    ERIC Educational Resources Information Center

    Boylan, Hunter R.

    2011-01-01

    This article presents an interview with Dr. Paul Nolting, a national expert in assessing individual math learning problems, developing effective student learning strategies, and assessing institutional variables that affect math success. Since his dissertation in 1986 on improving math success with study skills Dr. Nolting has consulted with over…

  8. 13. Photocopy of 1875 stereograph. Original in Paul A. Kohl's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of 1875 stereograph. Original in Paul A. Kohl's office, Tower Grove, Missouri Botanical Garden. HENRY SHAW AND TWO GUESTS IN HIS LANDAU DRAWN BY A MATCHED PAIR IN FRONT OF THE EAST GATE - Tower Grove Park, East Gate Entrance, 4255 Arsenal Street, Saint Louis, Independent City, MO

  9. April 2017 Marshall Association luncheon with Madison mayor Paul

    NASA Image and Video Library

    2017-03-03

    Paul Finley, mayor of the City of Madison, Alabama, chats with Jody Singer, deputy director of NASA’s Marshall Space Flight Center, following the April 26 lunch meeting of the Marshall Association, the center's professional, employee service organization. Finley, the guest speaker for the event, served as mayor of Madison from 2008-2012 and was elected to the post again in 2016.

  10. College and University Speech Codes in the Aftermath of R.A.V v. City of St. Paul.

    ERIC Educational Resources Information Center

    Fraleigh, Douglas

    In the case of RAV v. City of St. Paul, a teenager was charged with violating the city's Bias-Motivated Crime Ordinance after being accused of burning a cross inside the fenced yard of a black family. In a 9-0 decision, the Supreme Court struck down the St. Paul ordinance, a decision which raised a question as to whether many college and…

  11. The Paul Petzoldt Trivia Quiz: His Philosophy and Teaching Methods.

    ERIC Educational Resources Information Center

    Wagstaff, Mark

    Paul Petzoldt, co-founder of the Wilderness Education Association (WEA), helped mold the profession of outdoor leadership as we know it today. After his death in 1999, numerous field journals, old speeches, and personal correspondence were salvaged in order to refresh, clarify, and preserve Petzoldt's philosophy and teaching methods. The…

  12. Paul Trap Simulator Experiment (PTSX) to simulate intense beam propagation through a periodic focusing quadrupole field

    NASA Astrophysics Data System (ADS)

    Davidson, Ronald C.; Efthimion, Philip C.; Gilson, Erik; Majeski, Richard; Qin, Hong

    2002-01-01

    The Paul Trap Simulator Experiment (PTSX) is under construction at the Princeton Plasma Physics Laboratory to simulate intense beam propagation through a periodic quadrupole magnetic field. In the Paul trap configuration, a long nonneutral plasma column is confined axially by dc voltages on end cylinders at z=+L and z=-L, and transverse confinement is provided by segmented cylindrical electrodes with applied oscillatory voltages ±V0(t) over 90° segments. Because the transverse focusing force is similar in waveform to that produced by a discrete set of periodic quadrupole magnets in a frame moving with the beam, the Paul trap configuration offers the possibility of simulating intense beam propagation in a compact laboratory facility. The experimental layout is described, together with the planned experiments to study beam mismatch, envelope instabilities, halo particle production, and collective wave excitations.

  13. Paul B. Pedersen (1936-2017).

    PubMed

    Lonner, Walter J; Draguns, Juris G

    2018-01-01

    Presents an obituary for Paul B. Pedersen, who passed away on January 11, 2017, in a Minnetonka, Minnesota hospital. In 1973 Pedersen convened a pathfinding APA (Division 9) symposium in Montreal that resulted in the publication in 1976 of Counseling Across Cultures (Pedersen, Lonner, and Draguns, Eds.). The first book of its kind, it became the "Granddaddy" of all subsequent books in that area. The seventh edition, published in 2016 (with Trimble and Scharron-del Rio, co-eds), benefitted from his steadfast encouragement, but his deteriorating health prevented a more active role. His epitaph may well be one of his wisest and oft-quoted sayings: "All interviewing and counseling is multicultural. Each client comes to the session embodying multiple voices from the past." (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  14. A simulation study for determination of refractive index dispersion of dielectric film from reflectance spectrum by using Paul wavelet

    NASA Astrophysics Data System (ADS)

    Tiryaki, Erhan; Coşkun, Emre; Kocahan, Özlem; Özder, Serhat

    2017-02-01

    In this work, the Continuous Wavelet Transform (CWT) with Paul wavelet was improved as a tool for determination of refractive index dispersion of dielectric film by using the reflectance spectrum of the film. The reflectance spectrum was generated theoretically in the range of 0.8333 - 3.3333 μm wavenumber and it was analyzed with presented method. Obtained refractive index determined from various resolution of Paul wavelet were compared with the input values, and the importance of the tunable resolution with Paul wavelet was discussed briefly. The noise immunity and uncertainty of the method was also studied.

  15. Vegetation and Mammuthus primigenius extinction history on St Paul Island, Alaska

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Newsom, L.; Belmecheri, S.; Culleton, B.; Williams, J. W.

    2014-12-01

    St. Paul Island, AK, part of the Pribilofs, is an island remnant of the Bering Land Bridge, a possible coastal Picea refugium at the last glacial maximum, and a Holocene refugium for Mammuthus primigenius. A prior pollen record from Lake Hill indicates that St. Paul was predominantly herb tundra during the last glacial maximum followed by a shrub tundra in the early Holocene (Colinvaux, 1980). Subsequently, three radiocarbon dates on bones from Qagnax Cave indicate a last appearance of Mammuthus primigenius of 6.5 ka on St. Paul (Veltre et al. 2008). In March 2013, our team retrieved a 13.5 m composite core from Lake Hill to refine the extinction timing chronology, assess environmental change during the extinction interval, and test hypotheses about vegetation-megafauna feedback. This paper reports the results from modern botanical survey and analyses of fossil pollen, Sporormiella and other coprophilous spores, anchored by a new radiocarbon chronology consisting of seven AMS dates. Presently, bryophytes, Equisetum, Poaceae, Juncaceae, Salix and Viola commonly occur at the lake margin, accompanied increasingly by sedge meadow taxa with greater distance from the water's edge, especially Cyperaceae, Asteraceae, Apiaceae, Lupinus, Rubus and Valeriana. Sporormiella is consistently present in low abundances (2%, ~700 grains/cm3) in the late glacial and early Holocene until a drop to zero at 6,050 yr BP, remaining absent during the middle and late Holocene when it reappears at 1904 AD. The timing of Sporormiella decline and reappearance match well to the youngest mammoth bone date and the historic reintroduction of reindeer (1911 AD) on St. Paul Island. After 11 ka, major pollen types include Apiaceae, Poaceae, Cyperaceae, Artemisia and Salix, with lower abundances of Betula, Alnus and Ericaceae, consistent with herb tundra with some shrubs. Degraded Picea pollen grains are found at 12,240 yr BP in very low concentrations (223 grains/cm3), indicating long

  16. Passings to note: Paul Michael Packman, MD; S. Charles Schulz, MD.

    PubMed

    Black, Donald W

    2018-02-01

    One of the keys to the success of Annals of Clinical Psychiatry has always been the tireless efforts of our dedicated Editorial Board. We recently lost 2 longtime Editorial Board members, Drs. Paul Michael Packman and S. Charles Schulz. Both will be greatly missed.

  17. Molecular Orbital (Hückel) Theory and Linus Pauling: A Historical Perspective

    NASA Astrophysics Data System (ADS)

    Sharma, Brahama D.

    1996-08-01

    This short article offers evidence contrary to the belief that Linus Pauling was somehow opposed to Hückel-type calculations and that he therefore provided little or no support to the school of scientists in the '60s who were engaged in these semiempirical calculations.

  18. SPEAKING, WRITING, AND LISTENING IN THE ST. PAUL ELEMENTARY SCHOOLS.

    ERIC Educational Resources Information Center

    AMBROSE, HELEN; AND OTHERS

    DESIGNED AS A RESOURCE FOR ELEMENTARY SCHOOL TEACHERS TO USE IN HELPING CHILDREN THINK CLEARLY AND COMMUNICATE EFFECTIVELY, THE ST. PAUL CURRICULUM GUIDE IS DIVIDED INTO THREE SECTIONS--SPEAKING, LISTENING, AND WRITING. AN OVERVIEW OF EACH SECTION DESCRIBES CURRENT THINKING IN THE FIELD AND GENERAL SKILLS WHICH NEED TO BE ACQUIRED BY STUDENTS.…

  19. Looking east at canal and R. Paul Smith Power Station. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking east at canal and R. Paul Smith Power Station. The dark trestle at right center carried the spur track to coal unloading facilities located in the space now occupied by the coal pile. - Potomac Edison Company, Chesapeake & Ohio Canal Bridge, Spanning C & O Canal South of U.S. 11, Williamsport, Washington County, MD

  20. Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha

    PubMed Central

    2012-01-01

    Background Currently, the two most commonly used fibrinolytic agents in thrombolytic therapy are recombinant tissue plasminogen activator (rt-PA) and streptokinase (SK). Whereas SK has the advantage of substantially lower costs when compared to other agents, it is less effective than either rt-PA or related variants, has significant allergenic potential, lacks fibrin selectivity and causes transient hypotensive effects in high dosing schedules. Therefore, development of an alternative fibrinolytic agent having superior efficacy to SK, approaching that of rt-PA, together with a similar or enhanced safety profile and advantageous cost-benefit ratio, would be of substantial importance. Pre-clinical data suggest that the novel fibrinolytic recombinant staphylokinase (rSAK), or related rSAK variants, could be candidates for such development. However, since an efficient expression system for rSAK is still lacking, it has not yet been fully developed or evaluated for clinical purposes. This study’s goal was development of an efficient fermentation process for the production of a modified, non-glycosylated, biologically active rSAK, namely rSAK-2, using the well-established single cell yeast Hansenula polymorpha expression system. Results The development of an efficient large scale (80 L) Hansenula polymorpha fermentation process of short duration for rSAK-2 production is described. It evolved from an initial 1mL HTP methodology by successive scale-up over almost 5 orders of magnitude and improvement steps, including the optimization of critical process parameters (e.g. temperature, pH, feeding strategy, medium composition, etc.). Potential glycosylation of rSAK-2 was successfully suppressed through amino acid substitution within its only N-acetyl glycosylation motif. Expression at high yields (≥ 1g rSAK-2/L cell culture broth) of biologically active rSAK-2 of expected molecular weight was achieved. Conclusion The optimized production process described for rSAK-2 in

  1. A Long DNA Segment in a Linear Nanoscale Paul Trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Joseph, Sony nmn; Guan, Weihau; Reed, Mark A

    2009-01-01

    We study the dynamics of a linearly distributed line charge such as single stranded DNA (ssDNA) in a nanoscale, linear 2D Paul trap in vacuum. Using molecular dynamics simulations we show that a line charge can be trapped effectively in the trap for a well defined range of stability parameters. We investigated (i) a flexible bonded string of charged beads and (ii) a ssDNA polymer of variable length, for various trap parameters. A line charge undergoes oscillations or rotations as it moves, depending on its initial angle, the position of the center of mass and the velocity. The stability regionmore » for a strongly bonded line of charged beads is similar to that of a single ion with the same charge to mass ratio. Single stranded DNA as long as 40 nm does not fold or curl in the Paul trap, but could undergo rotations about the center of mass. However, we show that a stretching field in the axial direction can effectively prevent the rotations and increase the confinement stability.« less

  2. Big City Superintendent as Powerful CEO: Paul Vallas in Philadelphia

    ERIC Educational Resources Information Center

    Useem, Elizabeth

    2009-01-01

    This case study of the leadership of Paul Vallas as CEO of the Philadelphia city schools from 2002-2007 demonstrates that No Child Left Behind has enhanced the formal authority of big city district chiefs even though they are constrained by its accountability mandates and by the pressures from a growing number of influential stakeholder groups. In…

  3. Paul of Aegina (ca 625-690 ad), Reconstructing Male Gynecomastia.

    PubMed

    Tsoucalas, Gregory; Sgantzos, Markos

    2017-06-01

    Paul of Aegina thrived with his innovative operations, practically creating a kind of a new surgical school. He had deeply believed in human's body perfection introducing a series of cosmetic operations. Among them stood the male's breasts reconstruction in the case of pseudo-gynecomastia. His intervention was replicated by both the western Europeans and the Arabs.

  4. Paul Ricoeur, Memory, and the Historical Gaze: Implications for Education Histories

    ERIC Educational Resources Information Center

    Colby, Sherri Rae

    2012-01-01

    In this article, the author shares the potential applications of Paul Ricoeur's philosophies of history, memory, and narrative to the interpretation of educational histories, and those histories' life spans: moving cyclically from early conception, to evidentiary construction, to published dissemination; and ultimately to death or immortality. Her…

  5. Astronaut Charles Conrad trims hair of Astronaut Paul Weitz

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Charles Conrad Jr., Skylab 2 commander, trims the hair of Astronaut Paul J. Weitz, Skylab 2 pilot, during the 28-day Skylab 2 mission in Earth orbit. They are in the crew quarters wardroom of the Orbital Workshop of the Skylab 1 and 2 space station. Weitz is holding a vacuum hose in his right hand. This picture was taken by Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot.

  6. Physical and Biological Modes of Thought in the Chemistry of Linus Pauling

    NASA Astrophysics Data System (ADS)

    Nye, Mary Jo

    No figure in modern chemistry better exemplifies than Linus Pauling (1901-1994) the intersections of the scientific disciplines of chemistry, physics, and biology nor the roles of physical and biological modes of thought in the 'central science' of chemistry.

  7. A cross-cultural comparison of eating behaviors and home food environmental factors in adolescents from São Paulo (Brazil) and Saint Paul/Minneapolis (USA)

    PubMed Central

    Estima, Camilla C.P.; Bruening, Meg; Hannan, Peter J.; Alvarenga, Marle S.; Leal, Greisse V.S.; Philippi, Sonia T.; Neumark-Sztainer, Dianne

    2015-01-01

    Objective Describe cross-cultural differences in nutrition-related factors among adolescents from São Paulo, Brazil and St. Paul/Minneapolis, U.S. Design Two large- population-based studies with cross-cultural comparisons Setting 12 São Paulo and 10 St. Paul/Minneapolis high schools in 2009-2010 Participants 1148 adolescents from São Paulo; 1632 adolescents from St. Paul/Minneapolis Main outcome measure(s) Meal consumption, family meals, fast food consumption and home food availability Analysis Binomial regressions, weighted for age distributions and adjusted for gender, were used to compare identical measures from each sample. Results Generally, São Paulo adolescents reported healthier nutritional outcomes than St. Paul/Minneapolis adolescents. São Paulo adolescents were seven times less likely to report high fast food consumption than St. Paul/Minneapolis adolescents (p<0.001). While most measures of the home environment indicated healthier home environments in São Paulo, more São Paulo adolescents reported that sugar-sweetened beverages was usually available at home than St. Paul/Minneapolis adolescents (p<0.001). Conclusions and implications São Paulo youth tended to have healthier eating behaviors and home food environment factors than St. Paul/Minneapolis youth. Brazilian eating patterns tend to be healthier and support a connection with food and culture. Interventions are needed to encourage youth and their families to maintain these patterns. PMID:24656651

  8. A cross-cultural comparison of eating behaviors and home food environmental factors in adolescents from São Paulo (Brazil) and Saint Paul-Minneapolis (US).

    PubMed

    Estima, Camilla C P; Bruening, Meg; Hannan, Peter J; Alvarenga, Marle S; Leal, Greisse V S; Philippi, Sonia T; Neumark-Sztainer, Dianne

    2014-01-01

    Describe cross-cultural differences in nutrition-related factors among adolescents from São Paulo, Brazil and St Paul-Minneapolis, US. Two large-population-based studies with cross-cultural comparisons. Twelve São Paulo and 10 St Paul-Minneapolis high schools in 2009-2010. A total of 1,148 adolescents from São Paulo and 1,632 adolescents from St Paul-Minneapolis. Meal consumption, family meals, fast-food consumption, and home food availability. Binomial regressions, weighted for age distributions and adjusted for gender, were used to compare identical measures from each sample. Generally, São Paulo adolescents reported healthier nutritional outcomes than St Paul-Minneapolis adolescents. São Paulo adolescents were 7 times less likely to report high fast-food consumption than St Paul-Minneapolis adolescents (P < .001). Whereas most measures of the home environment indicated healthier home environments in São Paulo, more São Paulo adolescents reported that sugar-sweetened beverages were usually available at home than did St Paul-Minneapolis adolescents (P < .001). São Paulo youth tended to have healthier eating behaviors and home food environment factors than St Paul-Minneapolis youth. Brazilian eating patterns tend to be healthier and support a connection with food and culture. Interventions are needed to encourage youth and their families to maintain these patterns. Copyright © 2014 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  9. Demonstrating the Principle of an rf Paul Ion Trap

    NASA Astrophysics Data System (ADS)

    Johnson, Andrew; Rabchuk, James

    2008-03-01

    An rf ion trap uses a time-varying electric field to trap charged ions. This is useful in applications related to quantum computing and mass spectroscopy. There are several mechanical devices described in the literature which have attempted to provide illustrative demonstrations of the principle of rf ion traps, including a mechanically-rotating ``saddle trap'' and the vertically-driven, inverted pendulum^1,2. Neither demonstration, however, successfully demonstrates BOTH the sinusoidal variation in the electric potential of the rf trap AND the parametric stability of the ions in the trap described by Mathieu's equation. We have modified a design of a one-dimensional ponderomotive trap^3 so that it satisfies both criteria for demonstrating the principle of an rf Paul trap. Our studies indicate that trapping stability is highly sensitive to fluxuations in the driving frequency. Results from the demonstration apparatus constructed by the authors will be presented. ^1 Rueckner, W., et al., ``Rotating saddle Paul trap,'' Am. J. Phys., 63 (2), February 1995. ^2 Friedman, M.H., et al., ``The inverted pendulum: A mechanical analogue of a quadrupole mass filter,'' Am. J. Phys., 50 (10), October 1982. ^3 Johnson, A.K. and Rabchuk, J.A., ``A One-Dimensional Ponderomotive Trap,'' ISAAPT 2007 spring meeting, WIU, March 30, 2007.

  10. Concordia U. Saint Paul Will Slash Tuition by One-Third

    ERIC Educational Resources Information Center

    Supiano, Beckie

    2012-01-01

    Concordia University Saint Paul will reduce the sticker price of its tuition and fees by $10,000, or about 33 percent, for the 2013-2014 academic year. Tuition and fees for all new and returning students in the traditional undergraduate program will drop to $19,700 next year from $29,700 this year, while the price of room and board will not…

  11. Homelessness and Work Experience: Two Years in Saint Paul. Final Report.

    ERIC Educational Resources Information Center

    Davis, Dennis R.

    A study explored the role of work experience in addressing problems of homeless people in Saint Paul (Minnesota) during the 1989-91 grant cycles of the McKinney Job Training for the Homeless Demonstration Program. The program included a number of elements: outreach, intake, assessment and enrollment, orientation, work experience, basic…

  12. The use of GIS for monitoring and predicting urban growth in east and west St Paul, Winnipeg, Manitoba, Canada.

    PubMed

    Hathout, S

    2002-11-01

    Most urban growth in Canada occurs in the urban-rural fringe. The increasing dispersal of the Canadian urban population is due to centrifugal forces pulling urbanites past the suburbs into the surrounding exurban communities. Most Canadian urban centres are located on prime agricultural land. Exurban sprawl devours an inordinate amount of the better agricultural land. The growth around the city of Winnipeg is a case in point. Within Winnipeg's urban field are the rural municipalities of East and West St Paul. The objective of this study is to investigate the impact of urban growth on the agricultural land of these RMs as well as the rate of urban growth in both Municipalities based on database analysis using aerial photographs taken in 1960 and 1989 and Geographic Information System (GIS). East St Paul was found to have a higher rate of urbanization (from 10.14% to 43.75%) between 1960 and 1989 than West St Paul (from 7.36% to 23.57%). The growth prediction using Markov probability chain analysis showed that East St Paul will henceforth experience a reduced rate of increase than West St Paul. The rate of urbanization for both RMs is found to be comparable with areas surrounding other major cities such as Toronto. The largest increases in urban land use categories occurred in and around the existing exurban settlements. It was found that most urbanization take place on the most fertile soil.

  13. Development of flood-inundation maps for the Mississippi River in Saint Paul, Minnesota

    USGS Publications Warehouse

    Czuba, Christiana R.; Fallon, James D.; Lewis, Corby R.; Cooper, Diane F.

    2014-01-01

    Digital flood-inundation maps for a 6.3-mile reach of the Mississippi River in Saint Paul, Minnesota, were developed through a multi-agency effort by the U.S. Geological Survey in cooperation with the U.S. Army Corps of Engineers and in collaboration with the National Weather Service. The inundation maps, which can be accessed through the U.S. Geological Survey Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ and the National Weather Service Advanced Hydrologic Prediction Service site at http://water.weather.gov/ahps/inundation.php, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the U.S. Geological Survey streamgage at the Mississippi River at Saint Paul (05331000). The National Weather Service forecasted peak-stage information at the streamgage may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the Mississippi River by means of a one-dimensional step-backwater model. The hydraulic model was calibrated using the most recent stage-discharge relation at the Robert Street location (rating curve number 38.0) of the Mississippi River at Saint Paul (streamgage 05331000), as well as an approximate water-surface elevation-discharge relation at the Mississippi River at South Saint Paul (U.S. Army Corps of Engineers streamgage SSPM5). The model also was verified against observed high-water marks from the recent 2011 flood event and the water-surface profile from existing flood insurance studies. The hydraulic model was then used to determine 25 water-surface profiles for flood stages at 1-foot intervals ranging from approximately bankfull stage to greater than the highest recorded stage at streamgage 05331000. The simulated water-surface profiles were then combined with a geographic information system digital elevation model, derived from high-resolution topography

  14. Paul Polani and the development of medical genetics

    PubMed Central

    Harper, Peter S.

    2007-01-01

    Paul Polani (1914-2006) was one of the key figures internationally in the beginnings and development of medical genetics. Best remembered scientifically for his highly original work on the basis of human sex chromosome disorders, notably Turner syndrome, he pioneered the application of basic biological research to clinical genetic problems. The unit that he founded in 1960, at Guys Hospital, London, provided an unparalleled model for combined research and service in medical genetics across a wide range of laboratory areas and helped to establish medical genetics as a specific discipline. PMID:17066298

  15. As it is in heaven? John Paul II listened to God and misunderstood the message.

    PubMed

    1993-10-27

    This articles focuses on John Paul II's 1993 Veritatis Splendor, an 1798 page encyclical letter to the Church's bishops on the crisis in the Catholic Church of family limitation and the implications for the laity and society. The communication states that a flexible interpretation of theology must be abandoned. Paul VI's 19963 Humanae Vitae is reportedly affirmed. John XXIII's spiritualism and concern with conscience is ignored. This encyclical is identified as not spoken "ex cathedra" or from the throne, which would have made the pronouncement true, unarguable forever, and subject to excommunication for those disobeying. Pope John Paul II is said to be preparing another encyclical on life issues and sexuality. Reference is made in this encyclical to devices that are acceptable to use to gauge a safe period for copulation without impregnation. The devices include the rectal thermometer and the calculator for determining the infertile days in the natural cycle. Veritatis Splendor's position on fertility is viewed as an issue of loyalty to the Church and not as an honest evaluation of the moral implications of artificial birth control. This encyclical comes closer to "ex cathedra" than the Humanae Vitae, which banned the birth control pill, IUD, spermicides, hormonal implants, vasectomies, and tubal ligation. Liberal Catholic theologians are reported to have interpreted Paul VI's statement that "God illuminates from within the hearts of the faithful and invites their assent," as a validation of dissent. Pope John Paul II closes the door to dissent in this proclamation. The Church also closes the door to free will for people to decide for themselves. The Jesuits, with different notions of divine will, are described as potentially concluding that the denial of free will and individual reason for the sake of Papal supremacy must be the work of the devil himself. For good Catholics this encyclical is interpreted as potentially forcing even stronger opposition to the

  16. Production of Ar{sup q+} ions with a tandem linear Paul trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Higaki, H., E-mail: hhigaki@hiroshima-u.ac.jp; Nagayasu, K.; Iwai, T.

    A tandem linear Paul trap was used to create highly charged Argon ions by electron impact ionizations. By improving the operation scheme, the production of Ar{sup 4+} ions was confirmed. Possible improvements for the future experiments with laser cooled Ca{sup +} ions are suggested.

  17. Astronaut Paul Weitz works with UV Stellar Astronomy Experiment

    NASA Image and Video Library

    1973-03-01

    S73-20716 (1 March 1973) --- Astronaut Paul J. Weitz, pilot of the first manned Skylab mission, works with the UV Stellar Astronomy Experiment S019 in the forward compartment of the Skylab Orbital Workshop (OWS) trainer during Skylab training at Johnson Space Center. The equipment consists of a reflecting telescope, a 35mm camera and an additional mirror. It is mounted in an anti-solar scientific airlock in the side of the OWS. Photo credit: NASA

  18. Paul Ion Trap as a Diagnostic for Plasma Focus

    NASA Astrophysics Data System (ADS)

    Sadat Kiai, S. M.; Adlparvar, S.; Zirak, A.; Alhooie, Samira; Elahi, M.; Sheibani, S.; Safarien, A.; Farhangi, S.; Dabirzadeh, A. A.; Khalaj, M. M.; Mahlooji, M. S.; KaKaei, S.; Talaei, A.; Kashani, A.; Tajik Ahmadi, H.; Zahedi, F.

    2010-02-01

    The plasma discharge contamination by high and low Z Impurities affect the rate of nuclear fusion reaction products, specially when light particles have to be confined. These impurities should be analyzed and can be fairly controlled. This paper reports on the development of a Paul ion trap with ion sources by impact electron ionization as a diagnostic for the 10 kJ Iranian sunshine plasma focus device. Preliminary results of the residual gas are analyzed and presented.

  19. E. Paul Torrance: His Life, Accomplishments, and Legacy. Research Monograph Series.

    ERIC Educational Resources Information Center

    Hebert, Thomas P.; Cramond, Bonnie; Neumeister, Kristie L. Speirs; Millar, Garnet; Silvian, Alice F.

    This monograph is designed to be a tribute to E. Paul Torrance, a renowned creativity researcher, university teacher, and mentor. It is presented in three sections, the first of which is a discussion of Torrance's life. It reviews his childhood in rural Georgia, his academic accomplishments, the emergence of his interest in creativity and the…

  20. A Report on Administrative Compensation Planning for St. Paul Public School Personnel.

    ERIC Educational Resources Information Center

    Hooker, Clifford P.; Mueller, Van D.

    This report describes and analyzes various devices and techniques that may be utilized in planning local school administrative compensation. The document outlines broad overall goals for compensation planning, describes and evaluates the application of a compensation plan in the St. Paul schools, and proposes alternative strategies for…

  1. Voice and Vision in Paul Zimmer's "The Great Bird of Love."

    ERIC Educational Resources Information Center

    Worsham, Fabian Clements

    Paul Zimmer's latest poetry collection, "The Great Bird of Love," is serious and somber, fraught with the burden of evil, the indifference of God, and the certainty of death. The book is not humorless, however, as humor is central to both the chaotic evil and the ordered goodness of human life. It is in this collection that it is…

  2. The Sagnac effect and its interpretation by Paul Langevin

    NASA Astrophysics Data System (ADS)

    Pascoli, Gianni

    2017-11-01

    The French physicist Georges Sagnac is nowdays frequently cited by the engineers who work on devices such as ring-laser gyroscopes. These systems operate on the principle of the Sagnac effect. It is less known that Sagnac was a strong opponent to the theory of special relativity proposed by Albert Einstein. He set up his experiment to prove the existence of the aether discarded by the Einsteinian relativity. An accurate explanation of the phenomenon was provided by Paul Langevin in 1921.

  3. Moral Perception and Judgment and a Truly Radical Change of Social Practices: A Reply to Paul Standish's "Registers of the Religious"

    ERIC Educational Resources Information Center

    Smeyers, Paul

    2012-01-01

    This article presents the author's response to Paul Standish's "Registers of the Religious". Addressing what he calls the "global", Paul Standish starts from MacIntyre's observation that people live in a world characterized by a vocabulary of value whose purchase on life is no longer authentically experienced: "MacIntyre's diagnosis of the…

  4. INTERRELATIONSHIPS BETWEEN IN-SITU GAS HYDRATES AND HEAVY OIL OCCURRENCES ON THE NORTH SLOPE OF ALASKA.

    USGS Publications Warehouse

    Collett, T.S.

    1985-01-01

    In 1973, during the drilling of the West Sak #1 well on the North Slope of Alaska, oil was first recovered from a shallow Cretaceous sand interval which was later informally named the West Sak sands by ARCO Alaska. Stratigraphically above the West Sak sands there are two additional oil bearing sands, and are informally referred to by ARCO as the Ugnu and the 2150 horizons. Gas hydrates are interpreted to exist in the West Sak #6 well in conjunction with heavy oil and the physical properties of this oil may have been influenced by the gas hydrate. Prior to this work, only experimental evidence suggested that hydrates and oil could exist in the same reservoir.

  5. Paul Ehrlich: pioneer of chemotherapy and cure by arsenic (1854-1915).

    PubMed Central

    Thorburn, A L

    1983-01-01

    Paul Ehrlich's experiments in staining techniques at the end of the nineteenth century resulted in many discoveries which help to form the basis of present research work. Ehrlich's chemotherapy research led to his formulating the arsenic compound, Salvarsan, which was used in the treatment of syphilis during the first half of this century until it was superseded by penicillin. Images PMID:6196079

  6. Excerpts from Vatican's "Veritatis Splendor," Pope John Paul II's Views of Moral Truth.

    ERIC Educational Resources Information Center

    Chronicle of Higher Education, 1993

    1993-01-01

    Excerpts are presented from a recent papal encyclical that sets forth John Paul II's views on timeless moral truths and on dissent from them within the Roman Catholic Church. The responsibility of bishops to monitor Catholic institutions, including educational institutions, is noted. (MSE)

  7. Astronaut Paul Weitz gets physical examination from Astronaut Joseph Kerwin

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Paul J. Weitz, Skylab 2 pilot, gets a physical examination by a fellow crewman during the 28-day Skylab 2 mission. Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot and a doctor of medicine, uses a stethoscope to check the Weitz's heartbeat. They are in the Orbital Workshop crew quarters of the Skylab 1 and 2 space station in Earth orbit. This photograph was taken by Charles Conrad Jr., Skylab 2 commander.

  8. A retrospective diagnosis of epilepsy in three historical figures: St Paul, Joan of Arc and Socrates.

    PubMed

    Muhammed, Louwai

    2013-11-01

    It has been suggested that undiagnosed epilepsy profoundly influenced the lives of several key figures in history. Historical sources recounting strange voices and visions may in fact have been describing manifestations of epileptic seizures rather than more supernatural phenomena. Well-documented accounts of such experiences exist for three individuals in particular: Socrates, St Paul and Joan of Arc. The great philosopher Socrates described a 'daimonion' that would visit him throughout his life. This daimonion may have represented recurrent simple partial seizures, while the peculiar periods of motionlessness for which Socrates was well known may have been the result of co-existing complex partial seizures. St Paul's religious conversion on the Road to Damascus may have followed a temporal lobe seizure which would account for the lights, voices, blindness and even the religious ecstasy he described. Finally, Joan of Arc gave a detailed narrative on the voices she heard from childhood during her Trial of Condemnation. Her auditory hallucinations appear to follow sudden acoustic stimuli in a way reminiscent of idiopathic partial epilepsy with auditory features. By analysing passages from historical texts, it is possible to argue that Socrates, St Paul and Joan of Arc each had epilepsy.

  9. STS-111 Crew Interviews: Paul Lockhart, Pilot

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-111 Pilot Paul Lockhart is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. He discusses the following mission goals: the crew transfer activities (the Expedition 5 crew is replacing the Expedition 4 crew on the International Space Station (ISS)), the delivery of the payloads which includes the Mobile Remote Servicer Base System (MBS), and the planned extravehicular activities (EVAs) which include attaching the MBS to the ISS and repairing the station's robot arm. He describes in-flight procedures for launch, reentry and docking with the ISS. He ends with his thoughts on the role of international cooperation in building and maintaining ISS.

  10. STS-113 Crew Interviews: Paul Lockhart, Pilot

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-113 Pilot Paul Lockhart is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Lockhart outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the primary mission payload (the P1 truss) and the crew transfer activities (Expedition 6 crew will replace the Expedition 5 Crew). Lockhart discusses the planned EVAs in detail and mentions what supplies will be left for the resident crew of the International Space Station (ISS). He ends with his thoughts about the importance of the ISS as the second anniversary of continuous human occupation of the space station approaches.

  11. Sun-Earth Day WEBCAST - NASA TV; Host Paul Mortfield, Astronomer Stanford Solar Center and visiting

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Sun-Earth Day WEBCAST - NASA TV; Host Paul Mortfield, Astronomer Stanford Solar Center and visiting students from San Francisco Bay Area Schools Documentation Technology Branch Video communications van (code-JIT)

  12. Ion-neutral-atom sympathetic cooling in a hybrid linear rf Paul and magneto-optical trap

    NASA Astrophysics Data System (ADS)

    Goodman, D. S.; Sivarajah, I.; Wells, J. E.; Narducci, F. A.; Smith, W. W.

    2012-09-01

    Long-range polarization forces between ions and neutral atoms result in large elastic scattering cross sections (e.g., ˜106a.u. for Na-Na+ or Na-Ca+ at cold and ultracold temperatures). This suggests that a hybrid ion-neutral trap should offer a general means for significant sympathetic cooling of atomic or molecular ions. We present simion 7.0 simulation results concerning the advantages and limitations of sympathetic cooling within a hybrid trap apparatus consisting of a linear rf Paul trap concentric with a Na magneto-optical trap (MOT). This paper explores the impact of various heating mechanisms on the hybrid system and how parameters related to the MOT, Paul trap, number of ions, and ion species affect the efficiency of the sympathetic cooling.

  13. Paul Tillich and psychoanalysis.

    PubMed

    Hart, Curtis W

    2011-09-01

    Paul Tillich (1886-1965) was one of the leading theologians of the twentieth century. Tillich was born in Germany and received his education and first academic appointments there. Tillich left Germany in 1933 to teach at Union Theological Seminary after having been dismissed from his university position by the National Socialist government for his radical views and political associations. In the United States, he became a highly successful lecturer, preacher, and public intellectual who reached numbers of persons who had departed or who had doubts regarding traditional religious belief and practice. Tillich underwent a series of traumatic losses in the early decades of his life that powerfully shaped his subsequent contributions to religious and cultural discourse. This essay outlines this pattern of loss and speculates about its impact upon his theological work. It lifts up Tillich's perspective of living and working "on the boundary" of disciplines, eras, and cultures, most particularly where psychoanalytic ideas contributed to his "theology of culture." It also stresses Tillich's role in initiating the ongoing dialogue between religion and psychiatry and psychoanalysis. The essay concludes with a summary critique of Tillich's work along with an affirmation of his considerable legacy. This essay was originally a presentation for the Richardson Research Seminar in the History of Psychiatry at Weill Cornell Medical College.

  14. At Paul Quinn, Students Till the Soil to Cultivate a Better College

    ERIC Educational Resources Information Center

    Kelderman, Eric

    2012-01-01

    In autumn, most colleges' football fields are covered with a thick carpet of grass or artificial turf and are adorned with yard lines. But the football field at Paul Quinn College was carved up by plowing and planting. This past fall, portions of the college's gridiron were covered with sweet potatoes, watermelons, peppers, rosemary, and sugar…

  15. Changes in abundance of vascular plants under varying silvicultural systems at the Forest Ecosystem Research and Demonstration Area, Paul Smiths, New York

    Treesearch

    Mark J. Twery; Elizabeth Olson; Gary L. Wade; Michael. Rechlin

    2013-01-01

    The Forest Ecosystem Research and Demonstration Area (FERDA) was established in 1998 adjacent to the Visitor Interpretive Center (VIC) for the Adirondack Park in Paul Smiths, NY, to provide visitors with first-hand exposure to forest management activities and to provide research opportunities for scientists and students at Paul Smith's College. This research note...

  16. Potential predecessors of the 2004 Indian Ocean Tsunami — Sedimentary evidence of extreme wave events at Ban Bang Sak, SW Thailand

    NASA Astrophysics Data System (ADS)

    Brill, D.; Brückner, H.; Jankaew, K.; Kelletat, D.; Scheffers, A.; Scheffers, S.

    2011-08-01

    Where historical records are short and/or fragmentary, geological evidence is an important tool to reconstruct the recurrence rate of extreme wave events (tsunamis and/or storms). This is particularly true for those coastal zones around the Indian Ocean, where predecessors of similar magnitude as the 2004 Indian Ocean Tsunami (IOT) have not been reported by written sources. In this context, the sedimentary record of the Holocene coastal plain of Ban Bang Sak (Phang-nga province, Thailand) provides evidence of multiple prehistoric coastal flooding events in the form of allochthonous sand beds, which were radiocarbon dated to 700-500, 1350-1180, and younger than 2000 cal BP. The layers were assigned to high-energy events of marine origin, which could be either tsunamis or tropical storms, by means of granulometry, geochemistry, vertical structure, and macrofossil content. Although no landfall of a strong storm has occurred in the last 150 years of meteorological data recording, cyclones cannot be ruled out for the last centuries and millennia. However, discrimination between tsunami and storm origin was mainly based on the comparison of the palaeoevent beds with the local deposit of the IOT, which revealed similar characteristics in regard to spatial extend and sediment properties. Furthermore, the youngest palaeoevent correlates with contemporaneous deposits from Thailand and more distant coasts. Hence, we relate it to a basin wide tsunami which took place 700-500 years ago. For the sediments of older extreme events, deposited between 2000 and 1180 cal BP, we found no unambiguous counterparts at other sites; nevertheless, at least for now, they are treated as tsunami candidates.

  17. The Paul A. Elsner Library and High Technology Complex--A Place for Learning.

    ERIC Educational Resources Information Center

    Moore, Chas. T., Jr.; Sugiyama, Kaoru K.

    2001-01-01

    Discusses the new Paul A. Elsner Library and High Technology Complex at Mesa Community College in Mesa, Arizona. Describes six planning goals for the facility, including access, integration of services, academic linkages, college services, district-wide services, and linkages with the community. Reports that the library offers faculty support…

  18. Systems Performance Analyses of Alaska Wind-Diesel Projects; St. Paul, Alaska (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baring-Gould, I.

    2009-04-01

    This fact sheet summarizes a systems performance analysis of the wind-diesel project in St. Paul, Alaska. Data provided for this project include load data, average wind turbine output, average diesel plant output, dump (controlling) load, average net capacity factor, average net wind penetration, estimated fuel savings, and wind system availability.

  19. Revolution and Education in Late Nineteenth Century France: The Early Career of Paul Robin.

    ERIC Educational Resources Information Center

    Mclaren, Angus

    1981-01-01

    Discusses the importance of the work of radical educator Paul Robin and the socio-political environment in nineteenth century France which prompted it. Robin advocated free, secular, public education for the working classes which stressed spontaneity, practicality, individualized instruction, and sexual equality. (AM)

  20. Use of a Linear Paul Trap to Study Random Noise-Induced Beam Degradation in High-Intensity Accelerators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chung, Moses; Gilson, Erik P.; Davidson, Ronald C.

    2009-04-10

    A random noise-induced beam degradation that can affect intense beam transport over long propagation distances has been experimentally studied by making use of the transverse beam dynamics equivalence between an alternating-gradient (AG) focusing system and a linear Paul trap system. For the present studies, machine imperfections in the quadrupole focusing lattice are considered, which are emulated by adding small random noise on the voltage waveform of the quadrupole electrodes in the Paul trap. It is observed that externally driven noise continuously produces a nonthermal tail of trapped ions, and increases the transverse emittance almost linearly with the duration of themore » noise.« less

  1. An Analysis of "City of Glass" by Paul Auster in Terms of Postmodernism

    ERIC Educational Resources Information Center

    Odacioglu, Mehmet Cem; Loi, Chek Kim; Çoban, Faddime

    2017-01-01

    This study analyzes "City of Glass," a postmodernist detective novella (or anti-detective) of the "New York Trilogy" by Paul Auster in terms of postmodernist elements and techniques such as metafiction, parody, intertextuality, irony and like. In doing so, some information about Auster's life and the plot of the work are also…

  2. STS-125 Flight Control Team in WFCR - Orbit 3 - Flight Director Paul Dye

    NASA Image and Video Library

    2009-05-20

    JSC2009-E-120846 (20 May 2009) --- The members of the STS-125 Orbit 3 flight control team pose for a group portrait in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center. Flight director Paul Dye (center left) is visible on the front row.

  3. Paul Gauguin in Brittany

    NASA Astrophysics Data System (ADS)

    Asmus, John F.

    2009-07-01

    Ever since the dawn of the 20th Century there has been a universal consensus that Alphonse Mucha launched the sensation that became known as Art Nouveau. This event was associated with the appearance of his Gismonda poster promoting the Sarah Bernhardt play of that name in Paris in 1894. At an estate sale in 1954 a small collage bearing a likeness of Mucha's Gismonda was offered. It had been fabricated by gluing slivers cut from sixty postage stamps to a 20cm ceramic tile. Digital computer image enhancement was applied to the collage design, initials on a walking stick from the same estate collection, and the Mucha poster. These geometrical analyses revealed that the collage is more detailed than the Mucha "original". This led to our hypothesis that the famous poster was a hasty photographic plagiarism of the intricate ceramic-tile collage. Image analyses of the initials on the companion walking stick revealed conformity with the famous enigmatic "P GO" monogram of Paul Gauguin. We conclude that Gauguin rather than Mucha created the Gismonda composition. Historical evidence suggests that, while Gauguin was in Brittany recovering from injuries sustained in a fistfight, Annah la Javanese stole his possessions and took them to Paris where her next lover, Mucha, copied the collage and presented it as his original poster design.

  4. Spatial instability of the rift in the St. Paul multifault transform fracture system, Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Sokolov, S. Yu.; Zaraiskaya, Yu. A.; Mazarovich, A. O.; Efimov, V. N.; Sokolov, N. S.

    2016-05-01

    The structure of the acoustic basement of the eastern part of the St. Paul multifault transform fracture system hosts rift paleovalleys and a paleonodal depression that mismatch the position of the currently active zones. This displacement zone, which is composed of five fault troughs, is unstable in terms of the position of the rift segments, which jumped according to redistribution of stresses. The St. Paul system is characterized by straightening of the transform transition between two remote segments of the Mid-Atlantic Ridge (MAR). The eastern part of the system contains anomalous bright-spot-like reflectors on the flattened basement, which is a result of atypical magmatism, that forms the standard ridge relief of the acoustic basement. Deformations of the acoustic basement have a presedimentation character. The present-day deformations with lower amplitude in comparison to the basement are accompanied by acoustic brightening of the sedimentary sequence. The axial Bouguer anomalies in the east of the system continue to the north for 120 km from the active segments of the St. Paul system. Currently seismically active segments of the spreading system are characterized by increasing amplitudes of the E-W displacement along the fault troughs. Cross-correlation of the lengths of the active structural elements of the MAR zone (segments of the ridge and transform fracture zones of displacement) indicates that, statistically, the multifault transform fracture system is a specific type of oceanic strike-slip faults.

  5. Inquiry and Irony: Promise and Paradox in Paul Jablon's "The Synergy of Inquiry"

    ERIC Educational Resources Information Center

    Nurenberg, David

    2016-01-01

    Paul Jablon's "The Synergy of Inquiry" (2014) is well-timed. The 2014 deadline set by No Child Left Behind (NCLB, 2002) for universal student proficiency has come and gone, and according to the National Assessment of Educational Progress, "proficiency rates last year were below 50 percent for nearly every racial and ethnic group, in…

  6. Time to Dream: "Reflections on Paul Diederich and the Progressive American High School"

    ERIC Educational Resources Information Center

    O'Connor, John S.; Lessing, Avi D.

    2015-01-01

    In this essay, John S. O'Connor and Avi D. Lessing discuss the increasingly reductive and routinized nature of contemporary schools and the costs such an approach holds for students and teachers alike. The current approach is especially troublesome in light of the rich history of progressive voices, such as Paul Diederich, who have cautioned…

  7. 75 FR 23804 - Notice of Inventory Completion: Paul H. Karshner Memorial Museum, Puyallup, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... made by the Paul H. Karshner Memorial Museum professional staff in consultation with representatives of... Memorial Museum, Puyallup, WA AGENCY: National Park Service, Interior. ACTION: Notice. Notice is here given... Memorial Museum, Puyallup, WA. The human remains were removed from the Aleutian Islands, AK. This notice is...

  8. Paul Abraham: A Forgotten Scholar of the Prussian Academy of Sciences and Humanities

    ERIC Educational Resources Information Center

    Thiel, Jens

    2004-01-01

    Paul Abraham, one of the Berlin Academy's most experienced researchers, was deported to Auschwitz in 1943. The fate of this Jewish scholar reveals much about the inner life of the Academy, and its treatment of Jewish staff, during the World War II. This paper describes his life, against a backdrop of war, revolution, and dictatorship, and in the…

  9. Why English Teachers MATTER: Some Reflections on the Life of Dr. Paul Brock

    ERIC Educational Resources Information Center

    Manuel, Jacqueline; Brock, Sophia; Brock, Amelia

    2017-01-01

    This special issue of "English in Australia" invited the wife (Jacqueline Manuel) and daughters (Sophia and Amelia Brock) of Paul Brock, who served fifty years as an educator, to provide this reflective piece on his influence as a leader in education, a writer, a teacher, a scholar, a mentor, and an advocate for medical research and…

  10. Paul Broca and French Brains: Portraits from the Life of an Eminent Neuroscientist

    ERIC Educational Resources Information Center

    LaPointe, Leonard L.

    2014-01-01

    Pierre Paul Broca is one of the most legendary neuroscientists of the last few centuries. His name graces a region of the brain, and his work is richly associated with human communication and its disorders. This article traces the contributions of this man and the historical context of his remarkable discoveries. After approval to visit and access…

  11. The rise of western rationalism: Paul Feyerabend's story.

    PubMed

    Preston, John

    2016-06-01

    I summarize certain aspects of Paul Feyerabend's account of the development of Western rationalism, show the ways in which that account is supposed to run up against an alternative, that of Karl Popper, and then try to give a preliminary comparison of the two. My interest is primarily in whether what Feyerabend called his 'story' constitutes a possible history of our epistemic concepts and their trajectory. I express some grave reservations about that story, and about Feyerabend's framework, finding Popper's views less problematic here. However, I also suggest that one important aspect of Feyerabend's material, his treatment of religious belief, can be given an interpretation which makes it tenable, and perhaps preferable to a Popperian approach. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Water resources of the Minneapolis-St. Paul Area, Minnesota

    USGS Publications Warehouse

    Prior, Charles Henry; Schneider, Robert; Durum, W.H.

    1953-01-01

    Waters from the drift deposits and bedrock formations overlying the Hinckley sandstone are hard and calcareous and generally contain troublesome quantities of iron. Regular treatment is required of some public-supply wells for removal of iron encrustations. Water fr.om these sources generally exceeds 300 ppm hardness, but in some places the St. Peter sandstone and St. Lawrence formation yield water of better quality. The Hinckley sandstone yields the best quality ground-water because of its comparatively lower hardness and uniform temperature (about 52 F). However, the average hardness of the treated municipal supplies of St. Paul and Minneapolis is considerably less than water from the Hinckley.

  13. Linus Pauling and the scientific debate over fallout hazards.

    PubMed

    Jolly, J Christopher

    2002-12-01

    From 1954 to 1963, numerous scientists engaged in a public debate over the possible hazards from radioactive fallout from nuclear weapons testing. Nobel laureate Linus Pauling, a California Institute of Technology chemist, was one of the most prominent. His scientific papers relating to the fallout debate reveal many of the scientific, social and political issues involved in the controversy. Although the public controversy ended after the signing of the 1963 Limited Test Ban Treaty, many of the scientific questions about the possible hazards of low-level radiation remain under debate within the scientific community. Moreover, the fallout debate was a prototype of current controversies over environmental and public-health hazards.

  14. Paul F-Brandwein Lecture 2006: Conservation Education for the 21st Century and beyond

    ERIC Educational Resources Information Center

    Roth, Charles E.

    2008-01-01

    This paper explores Paul Brandwein's contribution to the concept of conservation education in America. It examines the evolution of the concept to today's environmental education. It then identifies some of the weaknesses of current environmental education and presents ideas on how to move past them to a point where conservation education is…

  15. Point of view: Paul Simon.

    PubMed

    Simon, P

    1999-02-01

    In this article, former US Senator Paul Simon notes that, in his lifetime, the population of the world has tripled and is expected to quadruple. Among the effects of this population growth will be a 55% increase in nitrate emissions that will feed algae and compromise fish supplies. The US was extremely short-sighted when it reduced funding for the international family planning (FP) programs that benefit all nations. False accusations that the UN Population Fund (UNFPA) operates with a "bloated bureaucracy" ignore the fact that this agency has only 166 employees. More appropriate criticism would assert that the task the UNFPA is trying to accomplish is too important and too vast for such a small staff. Without FP programs, earth would now have to support an additional 400 million people. While contraceptive use by married women in developing countries has increased from 10% in 1965 to above 50% today and life expectancy is increasing, we must recognize the fact that we are currently unable to provide most of the world's population with safe water and sanitation and that increased population size will only exacerbate this problem. Encouraging voluntary FP is humanitarian and prudent and will help protect the entire population of the world.

  16. Paul Ehrlich: the Nobel Prize in physiology or medicine 1908.

    PubMed

    Piro, Anna; Tagarelli, Antonio; Tagarelli, Giuseppe; Lagonia, Paolo; Quattrone, Aldo

    2008-01-01

    We wish to commemorate Paul Ehrlich on the centennial of his being awarded the Nobel Prize in Physiology or Medicine in 1908. His studies are now considered as milestones in immunology: the morphology of leukocytes; his side-chain theory where he defined the cellular receptor for first time; and his clarification of the difference between serum therapy and chemotherapy. Ehrlich also invented the first chemotherapeutic drug: compound 606, or Salvarsan. We have used some original documents from the Royal Society of London, where Ehrlich was a fellow, and from Leipzig University, where he took a degree in medicine.

  17. Metabolism of 2-chlorobiphenyl suspension cultures of Paul's Scarlet rose

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fletcher, J.S.; Groeger, A.W.; McFarlane, J.C.

    1987-12-01

    Several studies have shown that plant-soil systems were capable of degrading chlorinated biphenyls, with the resulting accumulation of breakdown products in both the plants and the soil. However, since these studies were performed under field conditions, it is not certain what portion of the degradation was due to plant metabolism and what portion to that of soil microbes which have been demonstrated in pure culture to degrade chlorinated biphenyls. This question is addressed in the present research by determining the metabolism of (/sup 14/C)-labeled 2-chlorobiphenyl provided aseptically to axenic cultures of Paul's Scarlet rose.

  18. Historical antecedents to the philosophy of Paul Feyerabend.

    PubMed

    Munévar, Gonzalo

    2016-06-01

    Paul Feyerabend has been considered a very radical philosopher of science for proposing that we may advance hypotheses contrary to well-confirmed experimental results, that observations make theoretical assumptions, that all methodological rules have exceptions, that ordinary citizens may challenge the judgment of experts, and that human happiness should be a key value for science. As radical as these theses may sound, they all have historical antecedents. In defending the Copernican view, Galileo exemplified the first two; Mill, Aristotle and Machiavelli all argued for pluralism; Aristotle gave commonsense reasons for why ordinary citizens may be able to judge the work of experts; and a combination of Plato's and Aristotle's views can offer strong support for the connection between science and happiness. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Socrates, Augustine, and Paul Gauguin on the Reciprocity between Speech and Silence in Education

    ERIC Educational Resources Information Center

    Caranfa, Angelo

    2013-01-01

    While most educational practices today place an excessive amount of attention on discourse, this article attaches great importance to the reciprocity between speech and silence by drawing from the writings of Plato's Socrates, Augustine, and Paul Gauguin for whom this reciprocity is of the essence in learning. These three figures teach that…

  20. Change in the Minneapolis/St. Paul Metropolitan Area Oak Forests from 1991 to 1998

    Treesearch

    Kathleen Ward; Jennifer Juzwik

    2005-01-01

    Based on classifications of Landsat TM imagery, the total area of oak forests in the Minneapolis/St. Paul, Minnesota, metropolitan area decreased by 5.6 percent between 1991 and 1998, and oak forest losses ranged from 12 to 1,229 ha in six of seven ecological subsections. Maps and spatial data layers are provided.

  1. View of Payload specialist Paul Scully-Power during Zero-G training

    NASA Image and Video Library

    1984-07-16

    S84-37536 (18 July 1984) --- Astronaut Robert L. Crippen, left, 41-G crew commander watches as one of his fellow crewmembers gets an introduction to weightlessness aboard a KC-135, "zero-gravity" aircraft. Paul D. Scully-Power is the crew member literally floating here in the brief period of micro-gravity. Scully-Power, an oceanographer with the U.S. Navy, and Marc Garneau (partially visible in chair behind the floating Scully-Power)are payload specialists for 41-G. Garneau represents the National Research Council (Canada).

  2. Measurement of isotope ratio of Ca{sup +} ions in a linear Paul Trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hashimoto, Y.; Minamino, K.; Nagamoto, D.

    2009-03-17

    Measurement of isotope ratios of Calcium is very useful in many fields. So we demonstrated the measurement of isotope ratios of {sup 40}Ca{sup +}(abundance 96.4%) to {sup 44}Ca{sup +}(2.09%) ions in a linear Paul trap with several laser lights tuning to the isotope shifts. And we found that the experimental parameters had large influences on the measurement of the isotope ratios.

  3. Specificity of Structural Assessment of Knowledge

    ERIC Educational Resources Information Center

    Trumpower, David L.; Sharara, Harold; Goldsmith, Timothy E.

    2010-01-01

    This study examines the specificity of information provided by structural assessment of knowledge (SAK). SAK is a technique which uses the Pathfinder scaling algorithm to transform ratings of concept relatedness into network representations (PFnets) of individuals' knowledge. Inferences about individuals' overall domain knowledge based on the…

  4. 76 FR 1532 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... indicated that we plan to address the PM 10 needs for Nogales and Paul Spur/Douglas areas over the next few... certain columns and rows and thereby causes a mismatch between concentrations and the corresponding years...

  5. Publishing and Intergenerational Learning for the Future of Philosophy in Education: An Interview with Paul Smeyers

    ERIC Educational Resources Information Center

    Forster, Daniella J.

    2017-01-01

    Amongst a remarkable publishing career, Paul Smeyers, editor of the journal "Ethics and Education," has written extensively on the situation afflicting philosophy of education. A recently published editor's invited symposium in "Studies in Philosophy and Education" (Smeyers, De Ruyter, Waghid, & Strand, 2014) put forward…

  6. 77 FR 75589 - Prevailing Rate Systems; Redefinition of the Minneapolis-St. Paul, MN, and Southwestern Wisconsin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... 3206-AM75 Prevailing Rate Systems; Redefinition of the Minneapolis-St. Paul, MN, and Southwestern Wisconsin Appropriated Fund Federal Wage System Wage Areas AGENCY: U.S. Office of Personnel Management..., and Southwestern Wisconsin appropriated fund Federal Wage System wage areas. The proposed rule would...

  7. Paul Drude's Prediction of Nonreciprocal Mutual Inductance for Tesla Transformers

    PubMed Central

    McGuyer, Bart

    2014-01-01

    Inductors, transmission lines, and Tesla transformers have been modeled with lumped-element equivalent circuits for over a century. In a well-known paper from 1904, Paul Drude predicts that the mutual inductance for an unloaded Tesla transformer should be nonreciprocal. This historical curiosity is mostly forgotten today, perhaps because it appears incorrect. However, Drude's prediction is shown to be correct for the conditions treated, demonstrating the importance of constraints in deriving equivalent circuits for distributed systems. The predicted nonreciprocity is not fundamental, but instead is an artifact of the misrepresentation of energy by an equivalent circuit. The application to modern equivalent circuits is discussed. PMID:25542040

  8. Paul Drude's prediction of nonreciprocal mutual inductance for Tesla transformers.

    PubMed

    McGuyer, Bart

    2014-01-01

    Inductors, transmission lines, and Tesla transformers have been modeled with lumped-element equivalent circuits for over a century. In a well-known paper from 1904, Paul Drude predicts that the mutual inductance for an unloaded Tesla transformer should be nonreciprocal. This historical curiosity is mostly forgotten today, perhaps because it appears incorrect. However, Drude's prediction is shown to be correct for the conditions treated, demonstrating the importance of constraints in deriving equivalent circuits for distributed systems. The predicted nonreciprocity is not fundamental, but instead is an artifact of the misrepresentation of energy by an equivalent circuit. The application to modern equivalent circuits is discussed.

  9. The Perils of Paul: Near Disasters in Airborne Radiochemical Sampling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meade, Roger Allen

    Beginning with the Trinity test in July 1945, Laboratory radiochemists have collected debris from nuclear tests by various means. At Trinity, two United States Army Sherman tanks were used. Beginning with Operation Crossroads and continuing throughout atmospheric testing, aircraft were used to fly in and around mushroom clouds to collect debris. Paul Guthals, the LASL project leader for sampling operations, flew on many of the B-57 sampling missions. Two such missions, one flown over the Nevada Test and one in the skies near Johnston Atoll, again proved the dangers involved in collecting airborne test debris. The events of these twomore » missions are briefly recounted.« less

  10. Center for Transportation Studies 24th annual transportation research conference, May 22-23, 2013, Saint Paul, Minnesota.

    DOT National Transportation Integrated Search

    2013-05-01

    The University of Minnesotas Center for Transportation : Studies is pleased to present its 24th Annual Transportation : Research Conference, May 22-23, 2013. The conference will : be held at the Saint Paul RiverCentre, 175 West Kellogg : Boulevard...

  11. Detection of novel recombinases in bacteriophage genomes unveils Rad52, Rad51 and Gp2.5 remote homologs

    PubMed Central

    Lopes, Anne; Amarir-Bouhram, Jihane; Faure, Guilhem; Petit, Marie-Agnès; Guerois, Raphaël

    2010-01-01

    Homologous recombination is a key in contributing to bacteriophages genome repair, circularization and replication. No less than six kinds of recombinase genes have been reported so far in bacteriophage genomes, two (UvsX and Gp2.5) from virulent, and four (Sak, Redβ, Erf and Sak4) from temperate phages. Using profile–profile comparisons, structure-based modelling and gene-context analyses, we provide new views on the global landscape of recombinases in 465 bacteriophages. We show that Sak, Redβ and Erf belong to a common large superfamily adopting a shortcut Rad52-like fold. Remote homologs of Sak4 are predicted to adopt a shortcut Rad51/RecA fold and are discovered widespread among phage genomes. Unexpectedly, within temperate phages, gene-context analyses also pinpointed the presence of distant Gp2.5 homologs, believed to be restricted to virulent phages. All in all, three major superfamilies of phage recombinases emerged either related to Rad52-like, Rad51-like or Gp2.5-like proteins. For two newly detected recombinases belonging to the Sak4 and Gp2.5 families, we provide experimental evidence of their recombination activity in vivo. Temperate versus virulent lifestyle together with the importance of genome mosaicism is discussed in the light of these novel recombinases. Screening for these recombinases in genomes can be performed at http://biodev.extra.cea.fr/virfam. PMID:20194117

  12. A Short Biography of Paul A. M. Dirac and Historical Development of Dirac Delta Function

    ERIC Educational Resources Information Center

    Debnath, Lokenath

    2013-01-01

    This paper deals with a short biography of Paul Dirac, his first celebrated work on quantum mechanics, his first formal systematic use of the Dirac delta function and his famous work on quantum electrodynamics and quantum statistics. Included are his first discovery of the Dirac relativistic wave equation, existence of positron and the intrinsic…

  13. Project Early Kindergarten Evaluation: Results through 2009-10 of a Saint Paul Public Schools Initiative

    ERIC Educational Resources Information Center

    Maxfield, Jennifer; Gozali-Lee, Edith; Mueller, Dan

    2010-01-01

    Project Early Kindergarten (PEK) aims to improve the school-readiness of Saint Paul children and help close the achievement gap through offering high-quality educational experiences for preschool children. This report comes at the conclusion of the sixth year of PEK. Following an initial planning year (2004-05), PEK has served children through the…

  14. The Economic Impact of Ten Cultural Institutions on the Economy of the Minneapolis-St. Paul SMSA.

    ERIC Educational Resources Information Center

    Cwi, David

    The impact on the economy of 10 cultural institutions in the Minneapolis-St. Paul area was determined by measuring their 1978 direct and indirect fianancial effects. The institutions are the Children's Theatre Company, Chimera Theatre, Cricket Theatre, Guthrie Theatre, Minneapolis Institute of Arts, Minnesota Dance Theatre, Minnesota Orchestra,…

  15. Phonology and reading: a response to Wang, Trezek, Luckner, and Paul.

    PubMed

    Allen, Thomas E; Clark, M Diane; del Giudice, Alex; Koo, Daniel; Lieberman, Amy; Mayberry, Rachel; Miller, Paul

    2009-01-01

    Four critical responses to an article, "The Role of Phonology and Phonologically Related Skills in Reading Instruction for Students Who Are Deaf or Hard of Hearing" (Wang, Trezek, Luckner, & Paul, 2008), are presented. Issue is taken with the conclusions of the article by Wang and colleagues regarding the "necessary" condition of phonological awareness for the development of reading skills among deaf readers. Research findings (not cited by Wang and colleagues) are pointed out that reveal weak correlations between phonemic awareness and reading comprehension, and stronger correlations between other variables such as overall language skill and early exposure to a visual language.

  16. Paul Ehrenfest and the dilemmas of modernity.

    PubMed

    van Lunteren, Frans H; Hollestelle, Marijn J

    2013-09-01

    This essay considers the highly ambivalent attitude of the Austrian-Dutch physicist Paul Ehrenfest toward contemporary developments in both science and society. On the one hand, he was in the vanguard of the quantum and relativity revolutions, supported industrialization and economic planning based on mathematical models, and, in general, cherished technocratic ideals. The essay highlights several influences that shaped his attitude in these respects, from his ties with the Philips Physics Laboratory and his sojourns in the United States to the utopian visions of H. G. Wells. On the other hand, he was extremely worried about the harmful consequences of contemporary changes in science and society, such as specialization, the growing pace of city life, and the increasing dependence on modern technologies, be they material or mathematical. In this regard, he agreed with cultural critics such as Max Nordau, Henri Bergson, Ostwald Spengler, and Ludwig Klages. Rather than attempting to solve this paradox, the essay suggests that this kind of ambiguity characterized a great deal of innovative science in the period.

  17. Paul Sollier, Pierre Janet, and their vicinity.

    PubMed

    Walusinski, Olivier

    2014-01-01

    Paul Sollier (1861-1933) and Pierre Janet (1859-1947) shared the same fate: achieving fame during their lives, then slipping into obscurity. However, their work is highly relevant for describing and explaining hysteria in the tradition of Jean-Martin Charcot (1825-1893). Both men had their teacher's clinical perspicacity, which enabled them to accumulate detailed clinical and psychological descriptions. These were published in books that achieved success in their day. From his descriptions, Sollier deduced a pathophysiology of hysteria in which a psychic inhibition led to a functional deficit in sensory-motor areas. This is partially confirmed by current functional brain imaging techniques. As for Janet, he developed concepts which are still valid today, involving personality dissociation, what he referred to as 'fixed ideas', and the subconscious. Sollier and Janet both saw hysteria as a response to the trigger of an emotional shock, specific to certain personalities. While the fundamental work by Joseph Babinski (1857-1932) on hysterical paralysis did much to enrich neurological semiology, Sollier contributed a novel description of the pathophysiology of hysteria, and Janet elucidated its psychopathological mechanisms.

  18. The Problem of Untested Sexual Assault Kits: Why Are Some Kits Never Submitted to a Crime Laboratory?

    ERIC Educational Resources Information Center

    Patterson, Debra; Campbell, Rebecca

    2012-01-01

    Victims of sexual assault are often advised to seek postassault medical care to have a forensic exam, which includes evidence collection (termed a "sexual assault kit" [SAK]). After the exam, law enforcement personnel are supposed to submit the SAK to a crime laboratory for analysis. However, recent media reports suggest that in many communities…

  19. Musings on Paul Peterson's "School Politics Chicago Style" and on the Utility of Decision-Making Models.

    ERIC Educational Resources Information Center

    Murphy, Jerome T.

    In "School Politics Chicago Style," Paul E. Peterson is quick to credit Graham Allison's work. There are major differences between them, however. The authors reach different conclusions about the role of rationality and bargaining because they use different definitions, because of the influence of the dominant mode of thinking at the…

  20. St Paul fracture zone intratransform ridge basalts (Equatorial Atlantic): Insight within the mantle source diversity

    NASA Astrophysics Data System (ADS)

    Hemond, C.; Brunelli, D.; Maia, M.; Prigent, S.; Sichel, S. E.

    2017-12-01

    The St Paul Transform System offsets by 630 km the Equatorial Mid Atlantic Ridge at 1° N. It consists of four Major faults separating three intra transform ridge axes. Volcanic glassy samples were collected inside two intratransform ridge (ITR) segments during the COLMEIA cruise (Maia et al ; 2016) and samples from the third ITR available from a previous cruise ST PAUL (Hékinian et al. 2000). Major, trace elements and Hf, Pb, Sr and Nd isotopes were determined on selected hand picked glass chips. Few glassy samples recovered and analysed from abyssal hill samples open a time window of about 4.5 million years in the chemistry of the northern ITR. Results show that all samples are basaltic in composition but trace elements display contrasting images for the three ITR. The northern ITR samples are all light REE and highly incompatible enriched and are E-MORB; the central ITR samples display rather flat REE pattern with a level on enrichment of the HREE higher than the other two ITR and are T-MORB. Southern ITR samples are more heterogeneous N-MORB to T-MORB with a lower level of HREE. Isotopes reveal that the ITRs sample distinct mantle sources. In various isotope plans, the northern ITR samples plot together with published results from the MAR directly north of the St Paul F.Z. Therefore they exhibit some flavor of the Sierra Leone hotspot interacting with the MAR at 1.7°N. Central and southern ITR samples have very distinct composition from the northern ITR but resemble each other. However, for identical 206Pb/204Pb ratios, central ITR has slightly but significantly higher 207Pb/204Pb and 208Pb/204Pb, also higher 143Nd/144Nd for a given 87Sr/86Sr. Southern ITR is in chemical continuity of the MAR southward. So that central ITR samples display a rather specific composition. Off axis samples corresponding to the activity of the northern ITR up to 4.6 m.y. show that the hotspot contribution was even bigger on the spreading axis than today and might be fading with

  1. Insights into the crystal chemistry of Earth materials rendered by electron density distributions: Pauling's rules revisited

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gibbs, Gerald V.; Ross, Nancy L.; Cox, David F.

    2014-05-20

    Pauling's first two rules are examined in terms of the accumulation of the electron density between bonded pairs of atoms for a relatively large number of oxide and silicate crystals and siloxane molecules. The distribution of the electron density shows that the radius of the oxygen atom is not fixed, but that it actually decreases systematically from ~1.40 Å to ~ 0.65 Å as the polarizing power and the electronegativity of the bonded metal atoms increase and the distribution of the O atom is progressively polarized and contracted along the bond vectors by the impact of the bonded interactions. Themore » contractions result in an aspherical oxygen atom that displays as many different bonded “radii” as it has bonded interactions. The bonded radii for the metal atoms match the Shannon and Prewitt ionic radii for the more electropositive atoms like potassium and sodium, but they are systematically larger for the more electronegative atoms like aluminum, silicon and phosphorous. Pauling's first rule is based on the assumption that the radius of the oxide anion is fixed and that the radii of the cations are such that radius sum of the spherical oxide anion and a cation necessarily equals the separation between the cation-anion bonded pair with the coordination number of the cation being determined by the ratio of the radii of the cation and anion. In the case of the bonded radii, the sum of the bonded radii for the metal atoms and the oxide anion necessarily equals the bond lengths by virtue of the way that the bonded radii were determined in the partitioning of the electron density along the bond path into metal and O atom parts. But, the radius ratio for the O and M atoms is an unsatisfactory rule for determining the coordination number of the metal atom inasmuch as a bonded O atom is not, in general, spherical, and its size varies substantially along its bonded directions. But by counting the number of bond paths that radiate from a bonded atom, the

  2. Vascular Plant Species of the Forest Ecology Research and Demonstration Area, Paul Smith's, New York

    Treesearch

    Gary L. Wade; Jonathan A. Myers; Cecilia R. Martin; Kathie Detmar; William, III Mator; Mark J. Twery; Mike Rechlin

    2003-01-01

    Five forest harvest methods (single-tree selection, group selection, two-age cut, shelterwood cut, and clearcut) are being demonstrated on 5-acre tracts near the Adirondack Park Agency?s Visitor Interpretation Center (VIC) at Paul Smith?s, New York. The tracts are part of the agency?s Forest Ecology Research and Demonstration Area. A primary goal is to show visitors...

  3. 77 FR 42672 - Radio Broadcasting Services; Alberton, MT; Crystal Falls, MI; Saint Paul, AR; and Waitsburg, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [MB Docket No. 12-115; DA 12-1084] Radio Broadcasting Services; Alberton, MT; Crystal Falls, MI; Saint Paul, AR; and Waitsburg, WA AGENCY: Federal Communications Commission. ACTION: Final rule. SUMMARY: The Audio Division, on its own motion, deletes four...

  4. Healthfulness of Foods Advertised in Small and Nontraditional Urban Stores in Minneapolis–St. Paul, Minnesota, 2014

    PubMed Central

    Pelletier, Jennifer E.; Erickson, Darin J.; Caspi, Caitlin E.; Harnack, Lisa J.; Laska, Melissa N.

    2016-01-01

    Introduction Shopping at small food stores, such as corner stores and convenience stores, is linked with unhealthful food and beverage purchases, poor diets, and high risk of obesity. However, information on how foods and beverages are marketed at small stores is limited. The objective of this study was to examine advertisements and product placements for healthful and less healthful foods and beverages at small stores in Minneapolis–St. Paul, Minnesota. Methods We conducted in-store audits of 119 small and nontraditional food retailers (corner/small grocery stores, food–gas marts, pharmacies, and dollar stores) randomly selected from licensing lists in Minneapolis–St. Paul in 2014. We analyzed data on exterior and interior advertisements of foods and beverages and product placement. Results Exterior and interior advertisements for healthful foods and beverages were found in less than half of stores (exterior, 37% [44 of 119]; interior, 20% [24 of 119]). Exterior and interior advertisements for less healthful items were found in approximately half of stores (exterior, 46% [55 of 119]); interior, 66% [78 of 119]). Of the 4 store types, food–gas marts were most likely to have exterior and interior advertisements for both healthful and less healthful items. Corner/small grocery stores and dollar stores had fewer advertisements of any type. Most stores (77%) had at least 1 healthful item featured as an impulse buy (ie, an item easily reached at checkout), whereas 98% featured at least 1 less healthful item as an impulse buy. Conclusion Findings suggest imbalanced advertising and product placement of healthful and less healthful foods and beverages at small food stores in Minneapolis–St. Paul; less healthful items were more apt to be featured as impulse buys. Future interventions and polices should encourage reductions in advertisements and impulse-buy placements of unhealthful products, particularly in food–gas marts, and encourage advertisements of

  5. Healthfulness of Foods Advertised in Small and Nontraditional Urban Stores in Minneapolis-St. Paul, Minnesota, 2014.

    PubMed

    Barnes, Timothy L; Pelletier, Jennifer E; Erickson, Darin J; Caspi, Caitlin E; Harnack, Lisa J; Laska, Melissa N

    2016-11-10

    Shopping at small food stores, such as corner stores and convenience stores, is linked with unhealthful food and beverage purchases, poor diets, and high risk of obesity. However, information on how foods and beverages are marketed at small stores is limited. The objective of this study was to examine advertisements and product placements for healthful and less healthful foods and beverages at small stores in Minneapolis-St. Paul, Minnesota. We conducted in-store audits of 119 small and nontraditional food retailers (corner/small grocery stores, food-gas marts, pharmacies, and dollar stores) randomly selected from licensing lists in Minneapolis-St. Paul in 2014. We analyzed data on exterior and interior advertisements of foods and beverages and product placement. Exterior and interior advertisements for healthful foods and beverages were found in less than half of stores (exterior, 37% [44 of 119]; interior, 20% [24 of 119]). Exterior and interior advertisements for less healthful items were found in approximately half of stores (exterior, 46% [55 of 119]); interior, 66% [78 of 119]). Of the 4 store types, food-gas marts were most likely to have exterior and interior advertisements for both healthful and less healthful items. Corner/small grocery stores and dollar stores had fewer advertisements of any type. Most stores (77%) had at least 1 healthful item featured as an impulse buy (ie, an item easily reached at checkout), whereas 98% featured at least 1 less healthful item as an impulse buy. Findings suggest imbalanced advertising and product placement of healthful and less healthful foods and beverages at small food stores in Minneapolis-St. Paul; less healthful items were more apt to be featured as impulse buys. Future interventions and polices should encourage reductions in advertisements and impulse-buy placements of unhealthful products, particularly in food-gas marts, and encourage advertisements of healthful products.

  6. Comments on "place and human development" by Paul Shepard and Yi-Fu Tuan's "experience and appreciation"

    Treesearch

    Florence C. Ladd

    1977-01-01

    Paul Shepard presents a dazzling array of profound ideas about the nature of the relationship between early developmental stages and places experienced in a variety of cultures. Shepard's analysis is related to the schema presented in Spivack's (1973) paper, in which he identifies some basic requirements of the human species and the environmental conditions...

  7. Dynamics of charged particles in a Paul radio-frequency quadrupole trap

    NASA Technical Reports Server (NTRS)

    Prestage, J. D.; Williams, A.; Maleki, L.; Djomehri, M. J.; Harabetian, E.

    1991-01-01

    A molecular-dynamics simulation of hundreds of ions confined in a Paul trap has been performed. The simulation includes the trapped particles' micromotion and interparticle Coulomb interactions. A random walk in velocity was implemented to bring the secular motion to a given temperature which was numerically measured. When the coupling Gamma is large the ions from concentric shells which undergo a quadrupole oscillation at the RF frequency, while the ions within a shell form a 2D hexagonal lattice. Ion clouds at 5 mK show no RF heating for q(z) less than about 0.6, whereas rapid heating is seen for qz = 0.8.

  8. High pressure research using muons at the Paul Scherrer Institute

    NASA Astrophysics Data System (ADS)

    Khasanov, R.; Guguchia, Z.; Maisuradze, A.; Andreica, D.; Elender, M.; Raselli, A.; Shermadini, Z.; Goko, T.; Knecht, F.; Morenzoni, E.; Amato, A.

    2016-04-01

    Pressure, together with temperature and magnetic field, is an important thermodynamical parameter in physics. Investigating the response of a compound or of a material to pressure allows to elucidate ground states, investigate their interplay and interactions and determine microscopic parameters. Pressure tuning is used to establish phase diagrams, study phase transitions and identify critical points. Muon spin rotation/relaxation (μSR) is now a standard technique making increasing significant contribution in condensed matter physics, material science research and other fields. In this review, we will discuss specific requirements and challenges to perform μSR experiments under pressure, introduce the high pressure muon facility at the Paul Scherrer Institute (PSI, Switzerland) and present selected results obtained by combining the sensitivity of the μSR technique with pressure.

  9. Baring the soul: Paul Bindrim, Abraham Maslow and 'nude psychotherapy'.

    PubMed

    Nicholson, Ian

    2007-01-01

    Nude psychotherapy is one of the most flamboyant therapeutic techniques ever developed in American psychology. Largely forgotten today, the therapy was an academic and popular sensation upon its introduction in 1967. Developed by psychologist Paul Bindrim, the therapy promised to guide clients to their authentic selves through the systematic removal of clothing. This paper explores the intellectual, cultural and ethical context of nude therapy and its significance as a form of unchurched spirituality. Although nude therapy has an indisputable tabloid character, it is also rooted in a long-standing academic search for authenticity and ultimate meaning through science. Bindrim's career demonstrates the historically long-standing interweaving of spirituality and science within American psychology while simultaneously highlighting the field's extraordinary capacity for adaptive reinvention.

  10. Steward of Headwaters: U.S. Army Corps of Engineers, St. Paul District, 1975-2000

    DTIC Science & Technology

    2012-01-01

    become one of the lead districts for low-head hydropower studies, but he could not make the St. Paul District a regional resource center for the...wildlife biology, archeology, history, economics and sociology. As a result of this infusion of new staff skills into the organization, the Corps acquired... economic aspects” of a project and others who wanted to modify projects “to enhance or preserve the environment.”62 The popular magazine Ms. examined

  11. [Urology and National Socialism. Paul Rosenstein 1875-1964, the disrupted biography of a Jewish urologist].

    PubMed

    Moll, F H; Krischel, M; Rathert, P; Fangerau, H

    2011-09-01

    The biography of Paul Rosenstein (1875-1964) serves as an example of the fate of a Jewish scientist at the beginning of the twentieth century in an area of conflict between the development of urology as a specialty at greater urban hospitals, professional achievements as a surgeon and scientist, drastic breaks during Nazi era and escape from Nazi terror via New York to Brazil.

  12. Economic effects of clean indoor air policies on bar and restaurant employment in Minneapolis and St Paul, Minnesota.

    PubMed

    Klein, Elizabeth G; Forster, Jean L; Erickson, Darin J; Lytle, Leslie A; Schillo, Barbara

    2010-01-01

    Clean indoor air (CIA) policies have been adopted by communities across the United States and internationally to protect employees in all workplaces from exposure to environmental tobacco smoke. Concerns have been raised that banning smoking in workplaces, particularly in bars and restaurants, will result in severe, negative economic effects. Although objective studies have consistently found no significant economic effects from CIA policies, the concerns persist that CIA policies will negatively affect hospitality businesses. Employment in bars and restaurants in Minneapolis and St Paul, Minnesota, was independently evaluated over a five-year period during which CIA policies were established in each city. An interrupted time series analysis was used to evaluate the short-, intermediate, and longer-term economic effects of the local CIA policies, accounting for the rest of the hospitality industry. The CIA policies were associated with an increase of three percent to four percent in employment for restaurants in Minneapolis and St Paul, after accounting for the rest of the hospitality industry. The CIA policies were inconsistent in their association with bar employment. A comprehensive CIA policy in Minneapolis was associated with an increase of five percent to six percent in bar employment, and St Paul had a one percent nonsignificant decrease in bar employment. The CIA policies continue to yield the best protection against workplace exposure to environmental tobacco smoke for bars and restaurant employees and were not associated with large employment changes for the short or longer term in two urban Midwestern cities in the United States.

  13. Integration of Rooftop Photovoltaic Systems in St. Paul Ford Site's Redevelopment Plans

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Olis, D.; Mosey, G.

    The purpose of this analysis is to estimate how much electricity the redeveloped Ford Motor Company assembly plant site in St. Paul, Minnesota, might consume under different development scenarios and how much rooftop photovoltaic (PV) generation might be possible at the site. Because the current development scenarios are high-level, preliminary sketches that describe mixes of residential, retail, commercial, and industrial spaces, electricity consumption and available rooftop area for PV under each scenario can only be grossly estimated. These results are only indicative and should be used for estimating purposes only and to help inform development goals and requirements moving forward.

  14. A history of gravity: An introduction to the epistemology of Paul Feyerabend

    NASA Astrophysics Data System (ADS)

    Rodrigues, Danilo Miranda

    2015-08-01

    The goal of this work is to show an historical introduction to epistemology of Paul Feyerabend and the importance of his concept of epistemological anarchism for education.Feyerabend defended that different and even contradictory theories must be used in education, this multiplicity of possible explanations for natural phenomena is important to express the real development of science.There are many different explanations for the fall of bodies, since the "natural places" in Aristotle until the Newtonian Gravitation or the General Relativity. The contact with many different explanations has as important contribution for the learning of Astronomy.

  15. The Greatest Priority for Genetic Counseling: Effectively Meeting Our Clients’ Needs 2014 NSGC Natalie Weissberger Paul National Achievement Award

    PubMed Central

    2016-01-01

    Receipt of the 2014 Natalie Weissberger Paul (NWP) National Achievement Award was a highlight of my career. Thank you to all who nominated me for this prestigious NSGC recognition. I am humbled to join past NWP award winners many of whom are admired mentors, treasured colleagues and friends. I would like to express what a privilege it is to honor Natalie Weissberger Paul for whom this award is named. Twenty-nine years ago I co-edited a volume of the Birth Defects Original Article Series with Natalie summarizing a conference co-funded by the March of Dimes and NSGC (Biesecker et al., 1987). Natalie demonstrated her devotion to children with special needs through her work at the March of Dimes. As such I believe she would concur with the focus of my remarks on the partners in our work: our clients. PMID:27220742

  16. 76 FR 65496 - Reorganization of Foreign-Trade Zone 119 Under Alternative Site Framework, Minneapolis/St. Paul, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1790] Reorganization of Foreign-Trade Zone 119 Under Alternative Site Framework, Minneapolis/St. Paul, MN Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the Foreign-Trade Zones Board...

  17. A compact electron cyclotron resonance proton source for the Paul Scherrer Institute's proton accelerator facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baumgarten, C.; Barchetti, A.; Einenkel, H.

    2011-05-15

    A compact electron cyclotron resonance proton source has been developed and installed recently at thePaul Scherrer Institute's high intensity proton accelerator. Operation at the ion source test stand and the accelerator demonstrates a high reliability and stability of the new source. When operated at a 10 - 12 mA net proton current the lifetime of the source exceeds 2000 h. The essential development steps towards the observed performance are described.

  18. Collecting, Preserving, and Interpreting the History of Electronic Games: An Interview with Jon-Paul C. Dyson

    ERIC Educational Resources Information Center

    American Journal of Play, 2017

    2017-01-01

    Jon-Paul C. Dyson is vice president for exhibits and director of the International Center for the History of Electronic Games (ICHEG) at The Strong. Trained as a cultural and intellectual historian, he joined The Strong in 1998 and has worked on and supervised the development of dozens of exhibits on play and video games. He initiated the museum's…

  19. Nonlinear resonances in linear segmented Paul trap of short central segment.

    PubMed

    Kłosowski, Łukasz; Piwiński, Mariusz; Pleskacz, Katarzyna; Wójtewicz, Szymon; Lisak, Daniel

    2018-03-23

    Linear segmented Paul trap system has been prepared for ion mass spectroscopy experiments. A non-standard approach to stability of trapped ions is applied to explain some effects observed with ensembles of calcium ions. Trap's stability diagram is extended to 3-dimensional one using additional ∆a besides standard q and a stability parameters. Nonlinear resonances in (q,∆a) diagrams are observed and described with a proposed model. The resonance lines have been identified using simple simulations and comparing the numerical and experimental results. The phenomenon can be applied in electron-impact ionization experiments for mass-identification of obtained ions or purification of their ensembles. This article is protected by copyright. All rights reserved.

  20. Preliminary Tests of a Paul ion Trap as an Ion Source

    NASA Astrophysics Data System (ADS)

    Sadat Kiai, S. M.; Zirak, A. R.; Elahi, M.; Adlparvar, S.; Mortazavi, B. N.; Safarien, A.; Farhangi, S.; Sheibani, S.; Alhooie, S.; Khalaj, M. M. A.; Dabirzadeh, A. A.; Ruzbehani, M.; Zahedi, F.

    2010-10-01

    The paper reports on the design and construction of a Paul ion trap as an ion source by using an impact electron ionization technique. Ions are produced in the trap and confined for the specific time which is then extracted and detected by a Faraday cup. Especial electronic configurations are employed between the end caps, ring electrodes, electron gun and a negative voltage for the detector. This configuration allows a constant low level of pure ion source between the pulsed confined ion sources. The present experimental results are based on the production and confinement of Argon ions with good stability and repeatability, but in principle, the technique can be used for various Argon like ions.

  1. [Jean-Louis-Paul Denucé (1824-1889): A forgotten pioneer of plastic surgery].

    PubMed

    Marck, K W; Martin, D

    2016-02-01

    The authors propose to define as main characterization of plastic reconstructive surgery the conceptual thinking that leads to a rational choice of an operative treatment. Conceptual thinking in plastic surgery started halfway the nineteenth century with the first schematic representations of the operative procedures available at that time, in which Von Ammon and Baumgarten, Szymanowski and Denucé played a prominent role. These four authors and their works are presented with special attention for the less known of them, Jean-Paul Denucé, surgeon in Bordeaux. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  2. Murine J774 Macrophages Recognize LPS/IFN-g, Non-CpG DNA or Two-CpG DNA-containing Sequences as Immunologically Distinct

    PubMed Central

    Crosby, Lynn; Casey, Warren; Morgan, Kevin; Ni, Hong; Yoon, Lawrence; Easton, Marilyn; Misukonis, Mary; Burleson, Gary; Ghosh, Dipak K.

    2010-01-01

    Specific bacterial lipopolysaccharides (LPS), IFN-γ, and unmethylated cytosine or guanosine-phosphorothioate containing DNAs (CpG) activate host immunity, influencing infectious responses. Macrophages detect, inactivate and destroy infectious particles, and synthetic CpG sequences invoke similar responses of the innate immune system. Previously, murine macrophage J774 cells treated with CpG induced the expression of nitric oxide synthase 2 (NOS2) and cyclo-oxygenase 2 (COX2) mRNA and protein. In this study murine J774 macrophages were exposed to vehicle, interferon γ + lipopolysaccharide (IFN-g/LPS), non-CpG (SAK1), or two-CpG sequence-containing DNA (SAK2) for 0–18 hr and gene expression changes measured. A large number of immunostimulatory and inflammatory changes were observed. SAK2 was a stronger activator of TNFα- and chemokine expression-related changes than LPS/IFN-g. Up regulation included tumor necrosis factor receptor superfamily genes (TNFRSF’s), IL-1 receptor signaling via stress-activated protein kinase (SAPK), NF-κB activation, hemopoietic maturation factors and sonic hedgehog/wingless integration site (SHH/Wnt) pathway genes. Genes of the TGF-β pathway were down regulated. In contrast, LPS/IFN-g -treated cells showed increased levels for TGF-β signaling genes, which may be linked to the observed up regulation of numerous collagens and down regulation of Wnt pathway genes. SAK1 produced distinct changes from LPS/IFN-g or SAK2. Therefore, J774 macrophages recognize LPS/IFN-g, non-CpG DNA or two-CpG DNA-containing sequences as immunologically distinct. PMID:20097302

  3. Paul F-Brandwein 2004 Lecture: Regarding the Ecology of Science Education: Connections to Environmental and Distance Education

    ERIC Educational Resources Information Center

    Bennett, Sheila K.; Bennett, Dean B.

    2004-01-01

    Paul F-Brandwein was a visionary who looked at education broadly. He left us with an insightful view of the ecology of education in which he identified three ecological systems: school-family-community, postsecondary, and cultural. The first part of this lecture, by Dean B. Bennett, examines Brandwein's ideas related to environmental education and…

  4. The spatial QRS-T angle in the Frank vectorcardiogram: accuracy of estimates derived from the 12-lead electrocardiogram.

    PubMed

    Schreurs, Charlotte A; Algra, Annemijn M; Man, Sum-Che; Cannegieter, Suzanne C; van der Wall, Ernst E; Schalij, Martin J; Kors, Jan A; Swenne, Cees A

    2010-01-01

    The spatial QRS-T angle (SA), a predictor of sudden cardiac death, is a vectorcardiographic variable. Gold standard vertorcardiograms (VCGs) are recorded by using the Frank electrode positions. However, with the commonly available 12-lead ECG, VCGs must be synthesized by matrix multiplication (inverse Dower matrix/Kors matrix). Alternatively, Rautaharju proposed a method to calculate SA directly from the 12-lead ECG. Neither spatial angles computed by using the inverse Dower matrix (SA-D) nor by using the Kors matrix (SA-K) or by using Rautaharju's method (SA-R) have been validated with regard to the spatial angles as directly measured in the Frank VCG (SA-F). Our present study aimed to perform this essential validation. We analyzed SAs in 1220 simultaneously recorded 12-lead ECGs and VCGs, in all data, in SA-F-based tertiles, and after stratification according to pathology or sex. Linear regression of SA-K, SA-D, and SA-R on SA-F yielded offsets of 0.01 degree, 20.3 degrees, and 28.3 degrees and slopes of 0.96, 0.86, and 0.79, respectively. The bias of SA-K with respect to SA-F (mean +/- SD, -3.2 degrees +/- 13.9 degrees) was significantly (P < .001) smaller than the bias of both SA-D and SA-R with respect to SA-F (8.0 degrees +/- 18.6 degrees and 9.8 degrees +/- 24.6 degrees, respectively); tertile analysis showed a much more homogeneous behavior of the bias in SA-K than of both the bias in SA-D and in SA-R. In pathologic ECGs, there was no significant bias in SA-K; bias in men and women did not differ. SA-K resembled SA-F best. In general, when there is no specific reason either to synthesize VCGs with the inverse Dower matrix or to calculate the spatial QRS-T angle with Rautaharju's method, it seems prudent to use the Kors matrix. Copyright 2010 Elsevier Inc. All rights reserved.

  5. Teaching to Make Disciples in a Higher Education Online Learning Environment: A Comparison of the Literature of Online Learning, the Objectives and Practices of Three Christian Colleges, and the Letters of Paul

    ERIC Educational Resources Information Center

    Morris, Raymond E.

    2012-01-01

    This dissertation explores engaging students in spiritual formation and discipleship in the online environment. This researcher begins with the proposition that the letters of Paul are examples of distance teaching and distance learning. The effectiveness of the letters of Paul in engaging their recipients in spiritual formation and discipleship…

  6. The Many Faces of Paul Robeson. The Constitution Community: Postwar United States (1945 to Early 1970s).

    ERIC Educational Resources Information Center

    Kelly, Kerry C.

    Paul Robeson was an athlete-scholar-concert artist-actor who was also an activist for civil and human rights. The son of a former slave, he was born and raised during segregation, lynching, and open racism. Robeson was one of the top performers of his time, earning more money than many white entertainers. His travels overseas opened his awareness…

  7. 33 CFR 207.320 - Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Mississippi River, Twin City... § 207.320 Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. In... the Twin City Locks and Dam, Minneapolis, in the interest of navigation, and supersedes rules and...

  8. 33 CFR 207.320 - Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Mississippi River, Twin City... § 207.320 Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. In... the Twin City Locks and Dam, Minneapolis, in the interest of navigation, and supersedes rules and...

  9. 33 CFR 207.320 - Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Mississippi River, Twin City... § 207.320 Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. In... the Twin City Locks and Dam, Minneapolis, in the interest of navigation, and supersedes rules and...

  10. 33 CFR 207.320 - Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Mississippi River, Twin City... § 207.320 Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. In... the Twin City Locks and Dam, Minneapolis, in the interest of navigation, and supersedes rules and...

  11. 33 CFR 207.320 - Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Mississippi River, Twin City... § 207.320 Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. In... the Twin City Locks and Dam, Minneapolis, in the interest of navigation, and supersedes rules and...

  12. Open letter to Pope John Paul II.

    PubMed

    Sai, F

    1991-01-01

    In an Open Letter to Pope John Paul II, written on World Population Day (July 11) 1991, Dr. Fred Sai, President of International Planned Parenthood Federation (IPPF), called for a dialogue on voluntary family planning as a means of avoiding unwanted pregnancy. A half million women die each year from pregnancy-related causes--a death toll that could be dramatically reduced by universal access to low cost, effective contraception. Family planning further represents the best protection against abortion. The Catholic Church's vehement opposition to abortion and family planning methods other than periodic abstinence is in marked contrast to its support to human rights in other settings. The Church has supported struggles for economic ju stice in and among nations, sided with the poor, and advocated for transitions to democracy. At the same time, the family planning movement--which has as its overall objective the protection of the health and welfare of women, children, and families--is viewed by the Vatican as a vehicle for the enslavement rather than liberation of women. The opening of a sensitive dialogue between the Catholic Church and supporters of voluntary family planning could help couples make sound moral decisions about their families and contribute to saving the lives of millions of women, most of them poor.

  13. Paul Spellman, Ph.D., Talks about TCGA at AACR 2011 - TCGA

    Cancer.gov

    Dr. Paul Spellman talks about The Cancer Genome Atlas (TCGA) and how this could help further the treatment of cancer. TCGA is a project working to catalog genetic mutations responsible for cancer. Clinicians are sequencing the genomes of patients with any of 20 different cancers and hope that this could target clinical trials at the specific patient sub-groups that would benefit most. Dr. Spellman explains how an increasing number of laboratories are becoming able to conduct genome sequencing and contribute to the TCGA project, discusses how clinicians could apply the findings in practice to decide on treatment and effect patient outlook and suggests that in future patients may start to request for their genome to be sequenced in order to aid their treatment.

  14. Hate Speech in Colleges and Universities--The Aftermath of "R.A.V. v. City of St. Paul, Minnesota".

    ERIC Educational Resources Information Center

    Brown, Valerie L.

    1993-01-01

    The Supreme Court ruled, in "R.A.V. v. City of St. Paul Minnesota," that the city's Biased-Motivated Crime Ordinance is unconstitutional. Discusses the factual background of "R.A.V.," of "Doe v. University of Michigan," and leading cases in the area of student first amendment rights. Draws conclusions and assesses…

  15. Pauling bond strength, bond length and electron density distribution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gibbs, Gerald V.; Ross, Nancy L.; Cox, David F.

    2014-01-18

    A power law regression equation, = 1.46(/r)-0.19, connecting the average experimental bond lengths, , with the average accumulation of the electron density at the bond critical point, , between bonded metal M and oxygen atoms, determined at ambient conditions for oxide crystals, where r is the row number of the M atom, is similar to the regression equation R(M-O) = 1.39(ρ(rc)/r)-0.21 determined for three perovskite crystals for pressures as high as 80 GPa. The two equations are also comparable with those, = 1.43( /r)-0.21, determined for a large number of oxide crystals at ambient conditions and = 1.39(/r)-0.22, determined formore » geometry optimized hydroxyacid molecules, that connect the bond lengths to the average Pauling electrostatic bond strength, , for the M-O bonded interactions. On the basis of the correspondence between the two sets of equations connecting ρ(rc) and the Pauling bond strength s with bond length, it appears that Pauling’s simple definition of bond strength closely mimics the accumulation of the electron density between bonded pairs of atoms. The similarity of the expressions for the crystals and molecules is compelling evidence that the M-O bonded interactions for the crystals and molecules 2 containing the same bonded interactions are comparable. Similar expressions, connecting bond lengths and bond strength, have also been found to hold for fluoride, nitride and sulfide molecules and crystals. The Brown-Shannon bond valence, σ, power law expression σ = [R1/(R(M-O)]N that has found wide use in crystal chemistry, is shown to be connected to a more universal expression determined for oxides and the perovskites, = r[(1.41)/]4.76, demonstrating that the bond valence for a bonded interaction is likewise closely connected to the accumulation of the electron density between the bonded atoms. Unlike the Brown-Shannon expression, it is universal in that it holds for the M-O bonded interactions for a relatively wide range of M atoms of the

  16. Generalized Slater--Pauling curve and the role of metalloids in Fe-based amorphous alloys

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sostarich, M.

    1990-05-01

    A modification of the generalized Slater--Pauling curve so as to consider the concentration dependence of the number of majority-spin {ital sp} electrons per average atom is proposed for amorphous iron-metalloid alloys. In this way an improved matching of the measured magnetic moment dependence on composition is achieved for Fe alloys with B and/or P as metalloids. Comparison of theory with experiment shows that amorphous Fe-P alloys tend to be magnetically rather strong, whereas their Fe-B counterparts are weak itinerant ferromagnets in almost the entire range of compositions.

  17. Proposed Barge Terminal Expansion, Packer River Terminal, Inc., South St. Paul, Dakota County, Minnesota.

    DTIC Science & Technology

    1977-09-01

    On 24 June 1974 Packer applied to the St. Paul District, Corps of Engineers (Corps) for a DOA permit under Section 10 of the River and Harbor Act of...exercised jurisdiction under Section 404 of P.L. 92-500 to the ordinary high water mark of the • Mississippi River, Thu’, even though the proposed project...Corps of Engineers was to expand their regulatory IT ril ct ion under Sect ion 404 of P.l.. 92-500 ,nd to promulgate new r- ’~giiI.,t .; ill conjunct

  18. From Biography to Osteobiography: An Example of Anthropological Historical Identification of the Remains of St. Paul.

    PubMed

    Mihanović, Frane; Jerković, Ivan; Kružić, Ivana; Anđelinović, Šimun; Janković, Stipan; Bašić, Željana

    2017-09-01

    In the identification process of historical figures, and especially in cases of Saint's bodies or mummified remains, any method that includes physical encroachment or sampling is often not allowed. In these cases, one of the few remaining possibilities is the application of nondestructive radiographical and anthropological methods. However, although there have been a few attempts of such analyses, no systematic standard methodology has been developed until now. In this study, we developed a methodological approach that was used to test the authenticity of the alleged body of Saint Paul the Confessor. Upon imaging the remains on MSCT and post-processing, the images were analyzed by an interdisciplinary team to explore the contents beneath the binding media (e.g., the remains) and to obtain osetobiographical data for comparison with historical biological data. Obtained results: ancestry, sex, age, occupation, and social status were consistent with historical data. Although the methodological approach proved to be appropriate in this case, due to the discrepancy in the amount of data, identity could not be fully confirmed. Nonetheless, the hypothesis that the remains do not belong to St. Paul was rejected, whilst positive identification receives support. Anat Rec, 300:1535-1546, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  19. Paul Natorp and the emergence of anti-psychologism in the nineteenth century.

    PubMed

    Edgar, Scott

    2008-03-01

    This paper examines the anti-psychologism of Paul Natorp, a Marburg School Neo-Kantian. It identifies both Natorp's principle argument against psychologism and the views underlying the argument that give it its force. Natorp's argument depends for its success on his view that certain scientific laws constitute the intersubjective content of knowledge. That view in turn depends on Natorp's conception of subjectivity, so it is only against the background of his conception of subjectivity that his reasons for rejecting psychologism make sense. This interpretation of Natorp suggests that attention paid to late nineteenth century theories of subjectivity and philosophy of psychology could improve our understanding of the emergence of anti-psychologism in that period.

  20. Control of Screening of a Charged Particle in Electrolytic Aqueous Paul Trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, Jae Hyun nmn; Krstic, Predrag S

    2011-01-01

    Individual charged particles could be trapped and confined in the combined radio-frequency and DC quadrupole electric field of an aqueous Paul trap. Viscosity of water improves confinement and extends the range of the trap parameters which characterize the stability of the trap. Electrolyte, if present in aqueous solution, may screen the charged particle and thus partially or fully suppress electrophoretic interaction with the applied filed, possibly reducing it to a generally much weaker dielectrophoretic interaction with an induced dipole. Applying molecular dynamics simulation we show that the quadrupole field has a different affects at the electrolyte ions and at muchmore » heavier charged particle, effectively eliminating the screening effect and reinstating the electrophoretic confinement.« less

  1. Relationships between urbanization and the oak resource of the Minneapolis/St. Paul metropolitan area from 1991 to 1998

    Treesearch

    Kathryn Kromroy; Kathleen Ward; Paul Castillo; Jennifer Juzwik

    2006-01-01

    Urbanization was associated with loss and transformation of the oak forest in the Twin Cities (Minneapolis and St. Paul) metropolitan area (TCMA) over a recent 7-year interval. Between 1991 and 1998, urbanization increased based on several indicators: population density, area of developed land, and area of impervious surface?total impervious area and area within three...

  2. Anarchist Epistemologies and the Separation of Science and State: The Critique and Relevance of Paul Feyerabend to Educational Foundations

    ERIC Educational Resources Information Center

    Wolfmeyer, Mark

    2017-01-01

    This article synthesizes Paul Feyerabend's controversial contributions to 20th-century philosophy of science through the synthesis of his works and the secondary literature, with specific foci on current trends in educational foundations and the potentials and pitfalls for applying Feyerabendian logics to our work. First, I situate his strains of…

  3. Rotational dynamics of a diatomic molecular ion in a Paul trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hashemloo, A.; Dion, C. M., E-mail: claude.dion@umu.se

    We present models for a heteronuclear diatomic molecular ion in a linear Paul trap in a rigid-rotor approximation, one purely classical and the other where the center-of-mass motion is treated classically, while rotational motion is quantized. We study the rotational dynamics and their influence on the motion of the center-of-mass, in the presence of the coupling between the permanent dipole moment of the ion and the trapping electric field. We show that the presence of the permanent dipole moment affects the trajectory of the ion and that it departs from the Mathieu equation solution found for atomic ions. For themore » case of quantum rotations, we also evidence the effect of the above-mentioned coupling on the rotational states of the ion.« less

  4. Remote sensing applications to hydrology in Minnesota. [Rice Creek watershed and St. Paul-Minneapolis metropolitan area

    NASA Technical Reports Server (NTRS)

    Brown, D.; Skaggs, R.

    1975-01-01

    Development of low lying southeastern shore of Pike Lake is described as part of the Rice Creek watershed study. Several small wetlands in Arden Hills, Minnesota were incorporated into the drainage plans as pollutant and nutrient sinks rather than being infilled. Lake water quality in the St. Paul-Minneapolis metropolitan area was analyzed using Landsat images. In the same urban area, the inventory and seasonal change of the open water were also studied.

  5. Review Symposium; Dancing on the Ceiling: A Study of Women Managers in Education, by Valerie Hall. London: Paul Chapman, 1996.

    ERIC Educational Resources Information Center

    Hall, Valerie; Gronn, Peter; Jenkin, Mazda; Power, Sally; Reynolds, Cecilia

    1999-01-01

    Hall and four colleagues review "Dancing on the Ceiling: A Study of Women Managers in Education" (Paul Chapman, 1996). Reviewers agree that Hall's profiles of six British elementary and secondary women headteachers should improve readers' understanding of female managers' development and their preference for "soft,"…

  6. I Hear America Humming and It Is out of Tune: Review of Paul G. Woodford's "Democracy and Music Education"

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2008-01-01

    This article presents the author's critique on Paul G. Woodford's positions with regard to music education and the notion of liberal democracy. The author seeks to broaden the contextual/historical scholarship around John Dewey and makes it clear that liberalism is a contested concept, as is democracy. He calls for contemporary responses to…

  7. Kepler's relation to the Jesuits-A study of his correspondence with Paul Guldin.

    PubMed

    Schuppener, Georg

    1997-12-01

    First, this article provides a survey of the kind of relationship that existed between Kepler and the Jesuits. Afterwards, it is pondered upon the likelihood of their having been in direct contact with each other while Kepler lived in Prague. The second part of the article is devoted to an investigation into the correspondence between Kepler and Paul Guldin as an example. Thus, the paper describes the key issues of those letters and concludes from this Guldin's attitude to Kepler and the resulting commitment to Kepler's affairs. Finally, the article examines whether the assumption that Kepler and Guldin later discontinued their correspondence intensionally is verifiable and plausible.

  8. From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages.

    PubMed

    Rodrigues-Martins, Ana; Riparbelli, Maria; Callaini, Giuliano; Glover, David M; Bettencourt-Dias, Monica

    2008-01-01

    Centrioles are essential for the formation of cilia, flagella and centrosome organization. Abnormalities in centrosome structure and number in many cancers can be associated with aberrant cell division and genomic instability.(1,2) Canonical centriole duplication occurs in coordination with the cell division cycle, such that a single new "daughter" centriole arises next to each "mother" centriole. If destroyed, or eliminated during development, centrioles can form de novo.(3-5) Here we discuss our recent data demonstrating a molecular pathway that operates in both de novo and canonical centriole biogenesis involving SAK/PLK4, SAS-6 and SAS-4.(6) We showed that centriole biogenesis is a self-assembly process locally triggered by high SAK/PLK4 activity that may or not be associated with an existing centriole. SAS-6 acts downstream of SAK/PLK4 to organize nine precentriolar units, which we call here enatosomes, fitting together laterally and longitudinally, specifying a tube-like centriole precursor.(7,8) The identification of mutants impaired in centriole biogenesis has permitted the study of the physiological consequences of their absence in the whole organism. In Drosophila, centrioles are not necessary for somatic cell divisions.(9,10) However, we show here that mitotic abnormalities arise in syncytial SAK/PLK4-derived mutant embryos resulting in lethality. Moreover male meiosis fails in both SAK/PLK4 and DSAS-4 mutant spermatids that have no centrioles. These results show diversity in the need for centrioles in cell division. This suggests that tissue specific constraints selected for different contributions of centrosome-independent and dependent mechanisms in spindle function. This heterogeneity should be taken into account both in reaching an understanding of spindle function and when designing drugs that target cell division.

  9. Control Of Screening Of A Charged Particle In Electrolytic Aqueous Paul Trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, Jae Hyun; Krstic, Predrag S.

    2011-06-01

    Individual charged particles could be trapped and confined by the combined radio-frequency and DC quadrupole electric field of an aqueous Paul trap. Viscosity of water improves confinement and extends the range of the trap parameters which characterize the stability of the trap. Electrolyte, if present in aqueous solution, may screen the charged particle and thus partially or fully suppress electrophoretic interaction with the applied filed, possibly reducing it to a generally much weaker dielectrophoretic interaction with an induced dipole. Applying molecular dynamics simulation we show that the quadrupole field has a different effect at the electrolyte ions and at muchmore » heavier charged particle, effectively eliminating the screening by electrolyte ions and reinstating the electrophoretic confinement.« less

  10. A transportable Paul-trap for levitation and accurate positioning of micron-scale particles in vacuum for laser-plasma experiments

    NASA Astrophysics Data System (ADS)

    Ostermayr, T. M.; Gebhard, J.; Haffa, D.; Kiefer, D.; Kreuzer, C.; Allinger, K.; Bömer, C.; Braenzel, J.; Schnürer, M.; Cermak, I.; Schreiber, J.; Hilz, P.

    2018-01-01

    We report on a Paul-trap system with large access angles that allows positioning of fully isolated micrometer-scale particles with micrometer precision as targets in high-intensity laser-plasma interactions. This paper summarizes theoretical and experimental concepts of the apparatus as well as supporting measurements that were performed for the trapping process of single particles.

  11. Paul Bunyan Takes A Wife--Developing Language, Reading, and Thinking Abilities through Creative Arts: An Alternative to Performance Centered Instruction.

    ERIC Educational Resources Information Center

    Ward, Pat; And Others

    This guide, designed for the elementary level, contains written and oral language activities involving the five senses which are intended to help teachers develop enthusiastic readers. The guide's five sections are as follows: (1) My Very Own Paul Bunyan Songbook; (2) A Logger's Log; (3) Teacher's Instructions for the Magic Wall and Parachute…

  12. Amorphous Slater-Pauling like behaviour in magnetic nanoparticles alloys synthesized in liquids

    NASA Astrophysics Data System (ADS)

    Boyer, Paul; Ménard, David; Meunier, Michel

    2012-09-01

    Nanoparticles of Fe, Co, Ni, and their alloys, with an average diameter of 12 nm were synthesized in liquids using a laser. Their saturation magnetization exhibited a Slater-Pauling-like behaviour with two main differences compared to that expected in bulk materials. First, the amplitude of the magnetization was found to be roughly 5 times smaller. Second, the disappearance of the ferromagnetic (FM) behaviour occurred at Ni instead of the expected Ni0.6Cu0.4. The behaviour can be explained by the presence of non-magnetic oxidized shells which reduced the fraction of ferromagnetic atoms and induce through strain an amorphous structure in the metallic core. Annealing at 500 K leads to some crystallization of the particles and thus to a partial recovery of the expected magnetization.

  13. Collision course? Donald Trump, Paul Ryan, and the fate of Medicare.

    PubMed

    Oberlander, Jonathan

    2018-04-10

    The election of Donald Trump as president of the United States raises questions about the future of Medicare. How will Medicare fare under Republican-led government? There are several compelling reasons that the Trump administration and Congressional Republicans might avoid Medicare reform, including the political risks of taking on a popular program, the difficulties the party has encountered in trying to dismantle the Patient Protection and Affordable Care Act (ACA), the importance of older Americans to the GOP coalition, and President Trump's views about Medicare. However, because of fiscal pressures and the commitment of Speaker of the House Paul Ryan and other Republicans to entitlement reform, the GOP nonetheless could end up attempting to make major changes in Medicare. Alternatively, Republican efforts to repeal and undermine the ACA could unintentionally enhance the political fortunes of proposals to expand Medicare. Consequently, the fate of Medicare during the Trump administration remains highly uncertain.

  14. "Where could paul street boys play?" child psychotherapy as co-construction of a playground.

    PubMed

    Gonella, Vittorio

    2014-03-01

    In this clinical paper, I present the development of the foundation of a child psychoanalytic treatment to explain in clinical terms what it means to build a "playground," a place where a child could go to play. The aim of the paper, with references to Paul Street Boys, a famous novel by Ferenc Molnár, a Hungarian contemporary of Sándor Ferenczi, is to use the metaphor of the "playground" for describing how, thanks to his personal use of the setting, and thanks to the development of the relationship with the therapist, a traumatized child could gradually begin to build, together with the therapist, a place unknown in his past.

  15. One More Legacy of Paul F. Brandwein: Creating Scientists

    NASA Astrophysics Data System (ADS)

    Fort, Deborah C.

    2011-06-01

    This paper studies the influence of Paul F. Brandwein, author, scientist, teacher and mentor, publisher, humanist, and environmentalist, on gifted youngsters who later became scientists, based primarily on information gathered from surveys completed by 25 of his students and one colleague. It also traces his profound interactions with science educators. It illuminates the theories of Brandwein and his protégés and colleagues about the interaction of environment, schooling, and education and Brandwein's belief in having students do original research (that is, research whose results are unknown) on their way to discovering their future scientific paths. It tests Brandwein's 1955 hypothesis on the characteristics typical of the young who eventually become scientists, namely: Three factors are considered as being significant in the development of future scientists: a Genetic Factor with a primary base in heredity (general intelligence, numerical ability, and verbal ability); a Predisposing Factor, with a primary base in functions which are psychological in nature; an Activating Factor, with a primary base in the opportunities offered in school and in the special skills of the teacher. High intelligence alone does not make a youngster a scientist (p xix).

  16. Partial Ionic Character beyond the Pauling Paradigm: Metal Nanoparticles

    DOE PAGES

    Duanmu, Kaining; Truhlar, Donald G.

    2014-11-12

    A canonical perspective on the chemical bond is the Pauling paradigm: a bond in a molecule containing only identical atoms has no ionic character. However, we show that homonuclear silver clusters have very uneven charge distributions (for example, the C 2v structure of Ag 4 has a larger dipole moment than formaldehyde or acetone), and we show how to predict the charge distribution from coordination numbers and Hirshfeld charges. The new charge model is validated against Kohn–Sham calculations of dipole moments with four approximations for the exchange–correlation functional. We report Kohn–Sham studies of the binding energies of CO on silvermore » monomer and silver clusters containing 2–18 atoms. We also find that an accurate charge model is essential for understanding the site dependence of binding. In particular we find that atoms with more positive charges tend to have higher binding energies, which can be used for guidance in catalyst modeling and design. Furthermore, the nonuniform charge distribution of silver clusters predisposes the site preference of binding of carbon monoxide, and we conclude that nonuniform charge distributions are an important property for understanding binding of metal nanoparticles in general.« less

  17. A tribute to Dr. Paul A. J. Janssen: entrepreneur extraordinaire, innovative scientist, and significant contributor to anesthesiology.

    PubMed

    Stanley, Theodore H; Egan, Talmage D; Van Aken, Hugo

    2008-02-01

    Dr. Paul Janssen was the founder of Janssen Pharmaceutica and the developer of over 80 pharmaceutical compounds that proved useful in human, botanical, and veterinary medicine. He and his coworkers synthesized the fentanyl family of drugs, many other potent analgesics, droperidol, etomidate, and numerous other important medicines that were extremely useful in psychiatry, parasitology, gastroenterology, cardiology, virology, and immunology. Anesthesiology and medicine as a whole have benefited a great deal from his resourcefulness, creativity, and entrepreneurial spirit.

  18. Evaluation of baseline ground-water conditions in the Mosteiros, Ribeira Paul, and Ribeira Fajã Basins, Republic of Cape Verde, West Africa, 2005-06

    USGS Publications Warehouse

    Heilweil, Victor M.; Earle, John D.; Cederberg, Jay R.; Messer, Mickey M.; Jorgensen, Brent E.; Verstraeten, Ingrid M.; Moura, Miguel A.; Querido, Arrigo; Spencer,; Osorio, Tatiana

    2006-01-01

    This report documents current (2005-06) baseline ground-water conditions in three basins within the West African Republic of Cape Verde (Mosteiros on Fogo, Ribeira Paul on Santo Antão, and Ribeira Fajã on São Nicolau) based on existing data and additional data collected during this study. Ground-water conditions (indicators) include ground-water levels, ground-water recharge altitude, ground-water discharge amounts, ground-water age (residence time), and ground-water quality. These indicators are needed to evaluate (1) long-term changes in ground-water resources or water quality caused by planned ground-water development associated with agricultural projects in these basins, and (2) the feasibility of artificial recharge as a mitigation strategy to offset the potentially declining water levels associated with increased ground-water development.Ground-water levels in all three basins vary from less than a few meters to more than 170 meters below land surface. Continuous recorder and electric tape measurements at three monitoring wells (one per basin) showed variations between August 2005 and June 2006 of as much as 1.8 meters. Few historical water-level data were available for the Mosteiros or Ribeira Paul Basins. Historical records from Ribeira Fajã indicate very large ground-water declines during the 1980s and early 1990s, associated with dewatering of the Galleria Fajã tunnel. More-recent data indicate that ground-water levels in Ribeira Fajã have reached a new equilibrium, remaining fairly constant since the late 1990s.Because of the scarcity of observation wells within each basin, water-level data were combined with other techniques to evaluate ground-water conditions. These techniques include the quantification of ground-water discharge (well withdrawals, spring discharge, seepage to springs, and gallery drainage), field water-quality measurements, and the use of environmental tracers to evaluate sources of aquifer recharge, flow paths, and ground

  19. EnviroAtlas - Minneapolis/St. Paul, MN - One Meter Resolution Urban Area Land Cover Map (MULC) (2010)

    EPA Pesticide Factsheets

    The Minneapolis-St. Paul, MN EnviroAtlas Meter-scale Urban Land Cover (MULC) data were generated from four-band (red, green, blue, and near infrared) aerial photography provided by the United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP). The NAIP imagery for the state of Minnesota was collected during the summer and fall of 2010. Lidar data and relevant ancillary datasets contributed to the classification. Eight land cover types were classified: water, impervious surface, soil and barren land, trees and forest, grass and herbaceous, agriculture, woody wetland, and emergent wetland. An accuracy assessment of 644 completely random and 62 stratified random photointerpreted reference points yielded an overall User's Accuracy of 83 percent. The boundary of this data layer is delineated by the US Census Bureau's 2010 Urban Statistical Area for Minneapolis-St. Paul, MN plus a 1-km buffer. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associat

  20. Two Traditions in the Social Studies Curriculum for the Elementary Grades: The Textbooks of Paul R. Hanna and Harold O. Rugg

    ERIC Educational Resources Information Center

    Bisland, Beverly Milner

    2009-01-01

    In the 1920s and 1930s, Paul R. Hanna and Harold O. Rugg developed new textbooks that integrated social studies curriculum in the elementary grades for the first time. Each author's curriculum; Hanna's expanding environments framework and Rugg's recurring concepts with a focus on contemporary issues has significantly impacted today's elementary…

  1. Impact of Lactobacillus curvatus 54M16 on microbiota composition and growth of Listeria monocytogenes in fermented sausages.

    PubMed

    Giello, Marina; La Storia, Antonietta; De Filippis, Francesca; Ercolini, Danilo; Villani, Francesco

    2018-06-01

    Lactobacillus curvatus 54M16 produced bacteriocins sak X, sak T α , sak T β and sak P. The aim of this study was to investigate the anti-listerial activity of the bacteriocins-producing strain against Listeria monocytogenes in vitro co-culture experiments and during the manufacture of fermented sausages. In MRS broth, Lb. curvatus 54M16 was able to inhibit L. monocytogenes to undetectable levels after 48 h at 20 °C or 5 days at 15 °C. Anti-listerial activity was lower during the production of fermented sausages with pathogen inoculation at levels of approximately 4 Log CFU g -1 . However, total inhibition of L. monocytogenes native to the raw ingredients was achieved over the course of the fermentation. Moreover, 16S rRNA-based analysis revealed the ability of Lb. curvatus 54M16 to dominate and affect the bacterial ecosystem, whereas spoilage-associated bacterial genera, such as Brochothrix, Psychrobacter, Pseudomonas and some Enterobacteriaceae, were found until the end of ripening in sausages without Lb. curvatus 54M16. The use of the bacteriocins-producing Lb. curvatus 54M16 in fermented sausages could be an important contribution to product safety, provided that eco-physiological factors and other preservation methods are maintained at levels required for the inhibition of pathogens in controlled conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Specificity in transition state binding: the Pauling model revisited.

    PubMed

    Amyes, Tina L; Richard, John P

    2013-03-26

    Linus Pauling proposed that the large rate accelerations for enzymes are caused by the high specificity of the protein catalyst for binding the reaction transition state. The observation that stable analogues of the transition states for enzymatic reactions often act as tight-binding inhibitors provided early support for this simple and elegant proposal. We review experimental results that support the proposal that Pauling's model provides a satisfactory explanation for the rate accelerations for many heterolytic enzymatic reactions through high-energy reaction intermediates, such as proton transfer and decarboxylation. Specificity in transition state binding is obtained when the total intrinsic binding energy of the substrate is significantly larger than the binding energy observed at the Michaelis complex. The results of recent studies that aimed to characterize the specificity in binding of the enolate oxygen at the transition state for the 1,3-isomerization reaction catalyzed by ketosteroid isomerase are reviewed. Interactions between pig heart succinyl-coenzyme A:3-oxoacid coenzyme A transferase (SCOT) and the nonreacting portions of coenzyme A (CoA) are responsible for a rate increase of 3 × 10(12)-fold, which is close to the estimated total 5 × 10(13)-fold enzymatic rate acceleration. Studies that partition the interactions between SCOT and CoA into their contributing parts are reviewed. Interactions of the protein with the substrate phosphodianion group provide an ~12 kcal/mol stabilization of the transition state for the reactions catalyzed by triosephosphate isomerase, orotidine 5'-monophosphate decarboxylase, and α-glycerol phosphate dehydrogenase. The interactions of these enzymes with the substrate piece phosphite dianion provide a 6-8 kcal/mol stabilization of the transition state for reaction of the appropriate truncated substrate. Enzyme activation by phosphite dianion reflects the higher dianion affinity for binding to the enzyme

  3. A Cultural Resources Survey of the Paul Pickle Permit Request Area, Bayou Deview - 7, Poinsett County, Arkansas.

    DTIC Science & Technology

    1989-12-01

    Resources Survey of the Paul Pickle I r., Pit j FUNONG NiMBERS Request Area, Bayou Deview -7 I-)oinsvtt Io., AR 9t*" 1I 2 6. AUTHOR(S)Jimmy D. McNeil. 1...undulating, with low ridges or natural levees rising a few feet above the alluvial terrace. These lowlands are characterized primarily by poorly...ridges. Slopes are generally less than 1%. Drainage is generally to the southwest with the major natural drainage way being the L’Anguille River

  4. Time of flight in MUSE at PIM1 at Paul Scherrer Institute

    NASA Astrophysics Data System (ADS)

    Lin, Wan; Gilman, Ronald; MUSE Collaboration

    2016-09-01

    The MUSE experiment at PIM1 at Paul Scherrer Institute in Villigen, Switzerland, measures elastic scattering of electrons and muons from a liquid hydrogen target. The intent of the experiment is to deduce whether the radius of the proton is the same when determined from the two different particle types. Precision timing is an important aspect of the experiment, used to determine particle types, reaction types, and beam momentum. Here we present results for a test setup measuring time of flight between prototypes of two detector systems to be used in the experiment, compared to Geant4 simulations. The results demonstrate time of flight resolution better than 100 ps, and beam momentum determination at the level of a few tenths of a percent. Douglass Project for Rutgers Women in Math, Science & Engineering, National Science Foundation Grant 1306126 to Rutgers University.

  5. How Christian ethics became medical ethics: the case of Paul Ramsey.

    PubMed

    Hauerwas, Stanley

    1995-03-01

    Over the last century Christian ethics has moved from an attempt to Christianize the social order to a quandary over whether being Christian unduly biases how medical ethics is done. This movement can be viewed as the internal development of protestant liberalism to its logical conclusion, and Paul Ramsey can be taken as one of the last great representatives of that tradition. By reducing the Christian message to the 'ethical upshot' of neighbour love, Ramsey did not have the resources to show how Christian practice might make a difference for understanding or forming the practice of medicine. Instead, medicine became the practice that exemplified the moral commitments of Christian civilization, and the goal of the ethicist was to identify the values that were constitutive of medicine. Ramsey thus prepared the way for the Christian ethicist to become a medical ethicist with a difference, and the difference simply involved vague theological presumptions that do no serious intellectual work other than explaining, perhaps, the motivations of the ethicist.

  6. [Paul Konitzer (1894-1947): hygienist, physician, social medicine and health politician].

    PubMed

    Schneck, Peter

    2004-01-01

    Paul Konitzer was one of the outstanding and well-known physicians in the years after the World War II in East-Germany. THe paper describes his professional way as hygienist, social medical, municipal physician and last but not least as health politician in the times of four different political regimes: the imperial era in Germany till 1918, the time of "Weimarer Republic" till 1933, the Nazi dictatorship till 1945 and the early years in the Soviet occupation zone of Germany. The life of Konitzer is a typical example of the fate of a German doctor in the first half of the 20th century. Konitzer was arrested in February 1947 by the Soviet Military Government in Berlin in connection with some political troubles and reproach with a typhus epidemic in a German camp for Russian Prisoners of War in the Nazi era. On April 22nd 1947 he died in prison of Dresden by suicide without condemnation.

  7. Theological reflections on donation after circulatory death: the wisdom of Paul Ramsey and Moshe Feinstein.

    PubMed

    Jotkowitz, A

    2008-10-01

    Due to the worldwide shortage of organs for transplantation, there has been an increased use of organs obtained after circulatory death alone. A protocol for this procedure has recently been approved by a major transplant consortium. This development raises serious moral and ethical concerns. Two renowned theologians of the previous generation, Paul Ramsey and Moshe Feinstein, wrote extensively on the ethical issues relating to transplantation, and their work has much relevance to current moral dilemmas. Their writings relating to definition of death, organ transplantation and the care of the terminally ill are briefly presented, and their potential application to the moral problem of organ donation after circulatory death is discussed.

  8. There's Madness in Your Method: A Philosophical Exploration into the Thought of Paul Feyerabend and Its Implications for Music Education

    ERIC Educational Resources Information Center

    Louth, Paul

    2014-01-01

    Drawing on the work of the philosopher of science Paul Feyerabend, this paper argues that the popular yet mistaken notion of scientific method has had a deleterious effect on music education by discouraging us from embracing conflict or pursuing counterinductive ways of thinking about music. Feyerabend argues that knowledge advances not according…

  9. Paul Gauguin and the origin of Art Noveau

    NASA Astrophysics Data System (ADS)

    Asmus, John F.

    1997-10-01

    Since the turn of the century there has been widespread acknowledgement that Alphonse Mucha inspired the birth of the Art Nouveau movement when he created the 'Gismonda' poster advertising the opening of the Sarah Bernhardt play of that name in Paris in 1894. At an estate sale in 1954 a small collage bearing a likeness of the Mucha 'Gismonda' was offered. It was composed of fragments of sixty postage stamps glued to a small ceramic tile. Digital computer image processing has been applied to the collage design, scratches on the handle of a walking stick in the same collection, and the Mucha poster. From comparative analyses of the enhanced 'Gismonda' images it is revealed that the little collage is considerably more detailed and compete than the Mucha 'original'. Thus, it is concluded that the poster is a hasty photographic plagiarism of the intricate collage. Further image processing of the scratches on the handle of the walking stick and the collage reveal them to conform to the famous and enigmatic 'P GO' monogram signature of the artist Paul Gauguin. Thus, it follows that the original design was created by Gauguin rather than by Mucha. It may be that while Gauguin was in Brittany recovering from injuries sustained in a brawl his former lover, Annah la Javanese, pilfered his belongings and took them with her to Paris and her next lover, photographer-designer, Alphonse Mucha, who copied the collage and offered it as the Gismonda Poster.

  10. Heavy oil recovery process: Conceptual engineering of a downhole methanator and preliminary estimate of facilities cost for application to North Slope Alaska

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gondouin, M.

    1991-10-31

    The West Sak (Upper Cretaceous) sands, overlaying the Kuparuk field, would rank among the largest known oil fields in the US, but technical difficulties have so far prevented its commercial exploitation. Steam injection is the most successful and the most commonly-used method of heavy oil recovery, but its application to the West Sak presents major problems. Such difficulties may be overcome by using a novel approach, in which steam is generated downhole in a catalytic Methanator, from Syngas made at the surface from endothermic reactions (Table 1). The Methanator effluent, containing steam and soluble gases resulting from exothermic reactions (Tablemore » 1), is cyclically injected into the reservoir by means of a horizontal drainhole while hot produced fluids flow form a second drainhole into a central production tubing. The downhole reactor feed and BFW flow downward to two concentric tubings. The large-diameter casing required to house the downhole reactor assembly is filled above it with Arctic Pack mud, or crude oil, to further reduce heat leaks. A quantitative analysis of this production scheme for the West Sak required a preliminary engineering of the downhole and surface facilities and a tentative forecast of well production rates. The results, based on published information on the West Sak, have been used to estimate the cost of these facilities, per daily barrel of oil produced. A preliminary economic analysis and conclusions are presented together with an outline of future work. Economic and regulatory conditions which would make this approach viable are discussed. 28 figs.« less

  11. Paul Goodman, 30 Years Later: "Growing Up Absurd"; "Compulsory Mis-Education, and The Community of Scholars"; and "The New Reformation"--A Retrospective

    ERIC Educational Resources Information Center

    Kaminsky, James S.

    2006-01-01

    This article is a retrospective account of the legacy of Paul Goodman's major educational works: "Growing Up Absurd"; "Compulsory Mis-education, and The Community of Scholars"; and "The New Reformation." It is argued here that what remains of interest in Goodman's work is to be found in the tropes and the anarchic Zeitgeist of his work. The legacy…

  12. EnviroAtlas - Minneapolis/St. Paul, MN - Ecosystem Services by Block Group

    EPA Pesticide Factsheets

    This EnviroAtlas dataset presents environmental benefits of the urban forest in 1,772 block groups in Minneapolis/St. Paul, Minnesota. Carbon attributes, temperature reduction, pollution removal and value, and runoff effects are calculated for each block group using i-Tree models (www.itreetools.org), local weather data, pollution data, EPA provided city boundary and land cover data, and U.S. Census derived block group boundary data. This dataset was produced by the US Forest Service to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  13. Pauling's electronegativity equation and a new corollary accurately predict bond dissociation enthalpies and enhance current understanding of the nature of the chemical bond.

    PubMed

    Matsunaga, Nikita; Rogers, Donald W; Zavitsas, Andreas A

    2003-04-18

    Contrary to other recent reports, Pauling's original electronegativity equation, applied as Pauling specified, describes quite accurately homolytic bond dissociation enthalpies of common covalent bonds, including highly polar ones, with an average deviation of +/-1.5 kcal mol(-1) from literature values for 117 such bonds. Dissociation enthalpies are presented for more than 250 bonds, including 79 for which experimental values are not available. Some previous evaluations of accuracy gave misleadingly poor results by applying the equation to cases for which it was not derived and for which it should not reproduce experimental values. Properly interpreted, the results of the equation provide new and quantitative insights into many facets of chemistry such as radical stabilities, factors influencing reactivity in electrophilic aromatic substitutions, the magnitude of steric effects, conjugative stabilization in unsaturated systems, rotational barriers, molecular and electronic structure, and aspects of autoxidation. A new corollary of the original equation expands its applicability and provides a rationale for previously observed empirical correlations. The equation raises doubts about a new bonding theory. Hydrogen is unique in that its electronegativity is not constant.

  14. Paul trap simulator experiment to model intense-beam propagation in alternating-gradient transport systems.

    PubMed

    Gilson, Erik P; Davidson, Ronald C; Efthimion, Philip C; Majeski, Richard

    2004-04-16

    The results presented here demonstrate that the Paul trap simulator experiment (PTSX) simulates the propagation of intense charged particle beams over distances of many kilometers through magnetic alternating-gradient (AG) transport systems by making use of the similarity between the transverse dynamics of particles in the two systems. Plasmas have been trapped that correspond to normalized intensity parameters s=omega(2)(p)(0)/2omega(2)(q)

  15. The Paul-Emile Victor group. to the rescue of the sea (in French)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The Paul-Emile Victor Group, which includes P. E. Victor, J. Auriol, A. Bombard, J. Y. Consteau, J. Debat, L. Leprince-Ringuet, and H. Tazieff, was formed to protect man and his environment, and for about a year has been prepared to deal with problems caused by marine pollution. Eight industrial firms, including the Compagnie Francaise des Petroles, supply chemical, financial, and scientific assistance. The Service d'Action and d'Assistance Marine d'Urgence and de Recherche (SAMUR), has three functions: corrective action, research and prevention, and education; it is divided into two sections: one comprising several rapid-action units (UNIR), and the other constituting amore » center for marine bioecological study and research (''cerber-mer''). The UNIR includes professional divers, pollution-control technicians, and biologists and goes into action immediately. The ''cerber-mer'' section will constitute a 24 hr information-exchange center for all of Europe.« less

  16. Paul de Kruif's Microbe Hunters and an outraged Ronald Ross.

    PubMed

    Chernin, E

    1988-01-01

    Paul de Kruif's book, Microbe Hunters, published in New York in 1926, was a romanticized medical "history," written in a breathless style, that describes the lives and works of a dozen famous figures, ranging from Leeuwenhoek to Sir Ronald Ross. Ross, who received the Nobel Prize in 1902 for his discovery that certain mosquitoes transmit malaria, resented de Kruif's personal remarks and his version of the malaria story, especially concerning the disputes with Italian workers over priorities. In a little-known polemic "review" of Microbe Hunters, Ross castigated de Kruif for statements he considered libelous. While Ross could not sue for libel across the Atlantic, his threatened action for libel forced the publisher of the British edition of Microbe Hunters to delete the chapter about Ross and one about David Bruce, Ross's countryman. de Kruif's book, a best-seller in its day and influential among the young for a generation, now seems gauche and anachronistic. While Ross seems to have been justified in some of his complaints about Microbe Hunters, the bitter tone of his reactions all but confirms de Kruif's opinion of him. Ross died in 1932 with a permanent niche in medical history; de Kruif died in 1971 and is little remembered except, perhaps, for Microbe Hunters.

  17. Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity.

    PubMed

    Elbing, Karin; Rubenstein, Eric M; McCartney, Rhonda R; Schmidt, Martin C

    2006-09-08

    The Snf1 kinase and its mammalian orthologue, the AMP-activated protein kinase (AMPK), function as heterotrimers composed of a catalytic alpha-subunit and two non-catalytic subunits, beta and gamma. The beta-subunit is thought to hold the complex together and control subcellular localization whereas the gamma-subunit plays a regulatory role by binding to and blocking the function of an auto-inhibitory domain (AID) present in the alpha-subunit. In addition, catalytic activity requires phosphorylation by a distinct upstream kinase. In yeast, any one of three Snf1-activating kinases, Sak1, Tos3, or Elm1, can fulfill this role. We have previously shown that Sak1 is the only Snf1-activating kinase that forms a stable complex with Snf1. Here we show that the formation of the Sak1.Snf1 complex requires the beta- and gamma-subunits in vivo. However, formation of the Sak1.Snf1 complex is not necessary for glucose-regulated phosphorylation of the Snf1 activation loop. Snf1 kinase purified from cells lacking the beta-subunits do not contain any gamma-subunit, indicating that the Snf1 kinase does not form a stable alphagamma dimer in vivo. In vitro kinase assays using purified full-length and truncated Snf1 proteins demonstrate that the kinase domain, which lacks the AID, is significantly more active than the full-length Snf1 protein. Addition of purified beta- and gamma-subunits could stimulate the kinase activity of the full-length alpha-subunit but only when all three subunits were present, suggesting an interdependence of all three subunits for assembly of a functional complex.

  18. Off-resonance energy absorption in a linear Paul trap due to mass selective resonant quenching

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sivarajah, I.; Goodman, D. S.; Wells, J. E.

    Linear Paul traps (LPT) are used in many experimental studies such as mass spectrometry, atom-ion collisions, and ion-molecule reactions. Mass selective resonant quenching (MSRQ) is implemented in LPT either to identify a charged particle's mass or to remove unwanted ions from a controlled experimental environment. In the latter case, MSRQ can introduce undesired heating to co-trapped ions of different mass, whose secular motion is off resonance with the quenching ac field, which we call off-resonance energy absorption (OREA). We present simulations and experimental evidence that show that the OREA increases exponentially with the number of ions loaded into the trapmore » and with the amplitude of the off-resonance external ac field.« less

  19. [Legal regulation of the personnel issues of military medicine during the reign of Paul I].

    PubMed

    Iskhakov, E R

    2015-08-01

    The article describes laws and regulations concerning the Russian army and navy, and accordingly its medical services accepted during the reign of Paul I. During this period different decrees aimed to improve medical personnel training in order to admit students to medical and surgical schools, reorganization of educational medical institutions, improving of professional skills of medical workers. Other decrees, aimed to improvement of recruitment of medical personnel of troops: the best students of had to be sent to troops instead physician assistant, medical staff increase and additional funding, countering the reduce of physicians' social welfare due to the inhumane attitude of the authorities, to regulate of the military medical service rotation order as well as assessment of their professional, moral, and psychological qualities.

  20. Persistence rates and detection probabilities of oiled king eider carcasses on St Paul Island, Alaska

    USGS Publications Warehouse

    Fowler, A.C.; Flint, Paul L.

    1997-01-01

    Following an oil spill off St Paul Island, Alaska in February 1996, persistence rates and detection probabilities of oiled king eider (Somateria spectabilis) carcasses were estimated using the Cormack-Jolly-Seber model. Carcass persistence rates varied by day, beach type and sex, while detection probabilities varied by day and beach type. Scavenging, wave action and weather influenced carcass persistence. The patterns of persistence differed on rock and sand beaches and female carcasses had a different persistence function than males. Weather, primarily snow storms, and degree of carcass scavenging, diminished carcass detectability. Detection probabilities on rock beaches were lower and more variable than on sand beaches. The combination of persistence rates and detection probabilities can be used to improve techniques of estimating total mortality.

  1. The Economic Impact of Ten Cultural Institutions on the Economy of the Minneapolis-St. Paul SMSA. Technical Supplement. Volume I [and] Volume II--Appendices.

    ERIC Educational Resources Information Center

    Cwi, David; Smith, D. Alden

    The research methods, procedures, and data for determining the impact of 10 fine arts institutions on the Minneapolis-St. Paul economy (1978) are outlined. A 30-equation model was used to identify a variety of effects on local businesses, government, and individuals. Researchers examined internal records of the 10 institutions as well as local,…

  2. Health assessment for Koppers Coke, St. Paul, Minnesota, Region 5. CERCLIS No. MND000819359. Preliminary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1989-06-27

    In 1981, the Koppers Coke Company Site was listed on the National Priorities List, due to extensive ground-water contamination. The 38-acre site, located in St. Paul, Minnesota, is a former coking facility that began operation in 1918. Eighteen contaminants have been identified in ground water from the surficial aquifer. Contamination has been found at a number of monitoring wells on-site and off-site, and at a residential well, a commercial well, and a cemetery well. The site is considered to be of potential public health concern because of the risk to human health caused by the possibility of exposure to hazardousmore » substances via ground water.« less

  3. A Novel Approach to β-delayed Neutron Spectroscopy Using the Beta-decay Paul Trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scielzo, N.D., E-mail: scielzo1@llnl.gov; Yee, R.M.; Department of Nuclear Engineering, University of California, Berkeley, CA 94720

    A new approach to β-delayed neutron spectroscopy has been demonstrated that circumvents the many limitations associated with neutron detection by instead inferring the decay branching ratios and energy spectra of the emitted neutrons by studying the nuclear recoil. Using the Beta-decay Paul Trap, fission-product ions were trapped and confined to within a 1-mm{sup 3} volume under vacuum using only electric fields. Results from recent measurements of {sup 137}I{sup +} and plans for development of a dedicated ion trap for future experiments using the intense fission fragment beams from the Californium Rare Isotope Breeder Upgrade (CARIBU) facility at Argonne National Laboratorymore » are summarized. The improved nuclear data that can be collected is needed in many fields of basic and applied science such as nuclear energy, nuclear astrophysics, and stockpile stewardship.« less

  4. Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today.

    PubMed

    Caslin, Heather L; Kiwanuka, Kasalina N; Haque, Tamara T; Taruselli, Marcela T; MacKnight, H Patrick; Paranjape, Anuya; Ryan, John J

    2018-01-01

    Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by cytokines and other microenvironmental stimuli. Playing a protective role in parasitic, bacterial, and viral infections, mast cells are also known for their role in the pathogenesis of allergy, asthma, and autoimmune diseases. Here, we review factors controlling mast cell activation, with a focus on receptor signaling and potential therapies for allergic disease. Specifically, we will discuss our work with FcεRI and FγR signaling, IL-4, IL-10, and TGF-β1 treatment, and Stat5. We conclude with potential therapeutics for allergic disease. Much of these efforts have been influenced by the work of Bill Paul. With many mechanistic targets for mast cell activation and different classes of therapeutics being studied, there is reason to be hopeful for continued clinical progress in this area.

  5. Responding to the Ideals of Lassallian Education in the 21st Century: A Case Study of St. Paul's Secondary School in Marsabit, Kenya

    ERIC Educational Resources Information Center

    Marius, Boya Francois; Teklemariam, Amanuel Abraha; Akala, Winston Jumba

    2011-01-01

    De La Salle Brothers are Christian educators operating in more than 80 countries, including Kenya. The purpose of this study was to find if the ideals of Lasallian education are being realized in the 21st century in Kenya and to establish whether the findings concur with the Lasallian philosophy of education. The study was conducted at St. Paul's…

  6. A Multicultural Glimpse of Rural and Urban Adolescence in Robert Newton Peck's "A Day No Pigs Would Die" and Paul Zindel's "The Pigman."

    ERIC Educational Resources Information Center

    Agnello, Mary Frances Linden

    "A Day No Pigs Would Die" by Robert Newton Peck and "The Pigman" by Paul Zindel are 2 short novels that offer treasures in the form of many lessons in life to share in the language arts classroom. These two rich novels can serve as sources for multicultural understanding of rural and urban life, as well as for interpreting the…

  7. Ultrafast state detection and 2D ion crystals in a Paul trap

    NASA Astrophysics Data System (ADS)

    Ip, Michael; Ransford, Anthony; Campbell, Wesley

    2016-05-01

    Projective readout of quantum information stored in atomic qubits typically uses state-dependent CW laser-induced fluorescence. This method requires an often sophisticated imaging system to spatially filter out the background CW laser light. We present an alternative approach that instead uses simple pulse sequences from a mode-locked laser to affect the same state-dependent excitations in less than 1 ns. The resulting atomic fluorescence occurs in the dark, allowing the placement of non-imaging detectors right next to the atom to improve the qubit state detection efficiency and speed. We also study 2D Coulomb crystals of atomic ions in an oblate Paul trap. We find that crystals with hundreds of ions can be held in the trap, potentially offering an alternative to the use of Penning traps for the quantum simulation of 2D lattice spin models. We discuss the classical physics of these crystals and the metastable states that are supported in 2D. This work is supported by the US Army Research Office.

  8. Occurrences of whale shark (Rhincodon typus Smith, 1828) in the Saint Peter and Saint Paul archipelago, Brazil.

    PubMed

    Hazin, F H V; Vaske Júnior, T; Oliveira, P G; Macena, B C L; Carvalho, F

    2008-05-01

    The Saint Peter and Saint Paul Archipelago in the central tropical Atlantic, is an important ground of whale sharks that are commonly sighted throughout the year close to the fishing boats in the adjacencies of the islands. In sightings reported between February 2000 and November 2005, the lengths of the individuals ranged between 1.8 to 14.0 m. The causes of these concentrations in the archipelago are still unclear, once there are no upwellings and plankton concentrations for feeding, and no reproductive activities were reported. Nevertheless, they could be associated to the spawning period of the abundant flying fishes, mainly in the first semester, when sightings were more frequent.

  9. John Paul Jones: An Overlooked Autopsy Finding that May Explain His Terminal Illness.

    PubMed

    Hamrell, Burt B

    2016-03-01

    A finding in the autopsy of John Paul Jones, the American Revolutionary War naval hero, may explain his terminal illness. During his last 2 years, he had a persistent productive cough and dyspnea. Ten days before death, he developed rapidly progressive dependent edema and ascites. He died in France in 1792. His body, preserved in alcohol in a lead coffin, was, in 1905, removed to the United States. Glomerulonephritis was noted on an autopsy, performed in France, but there was no comment then or since about ventricular wall thickness being the same in both ventricles at 5-6 mm. Hypertrophy and dilatation with biventricular failure followed by tissue shrinkage during 113 years in alcohol could have resulted in these ventricular wall findings. Systemic hypertension and left ventricular failure are consistent with his respiratory symptoms complicated perhaps by pulmonary emboli, right ventricular failure with tricuspid regurgitation, peripheral congestion, and jaundice. © 2015 American Academy of Forensic Sciences.

  10. Critical thinking in clinical nurse education: application of Paul's model of critical thinking.

    PubMed

    Andrea Sullivan, E

    2012-11-01

    Nurse educators recognize that many nursing students have difficulty in making decisions in clinical practice. The ability to make effective, informed decisions in clinical practice requires that nursing students know and apply the processes of critical thinking. Critical thinking is a skill that develops over time and requires the conscious application of this process. There are a number of models in the nursing literature to assist students in the critical thinking process; however, these models tend to focus solely on decision making in hospital settings and are often complex to actualize. In this paper, Paul's Model of Critical Thinking is examined for its application to nursing education. I will demonstrate how the model can be used by clinical nurse educators to assist students to develop critical thinking skills in all health care settings in a way that makes critical thinking skills accessible to students. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. PM[sub 10] ozone, and hospital admissions for the elderly in Minneapolis-St. Paul, Minnesota

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schwartz, J.

    Several recent studies have reported associations between airborne particles and/or ozone and hospital admissions for respiratory disease. PM[sub 10] has rarely been used as the particle exposure measure, however. This study examined whether such an association could be seen in Minneapolis-St. Paul, Minnesota, which has daily monitoring data for PM[sub 10]. Data on hospital admissions in persons aged 65 y and older were obtained from Medicare records for the years 1986 through 1989. Daily counts of admissions, by admit date, were computed for pneumonia (ICD9 480-487) and chronic obstructive pulmonary disease (COPD) (ICD9 490-496). Classification was by discharge diagnosis. Dailymore » air pollution data from all monitoring stations for ozone and PM[sub 10] in Minneapolis-St. Paul were obtained, and the daily average for each pollutant was computed. An average of approximately six pneumonia admissions and two admissions for chronic obstructive pulmonary disease occurred each day. Poisson regression analysis was used to control for time trends, seasonal fluctuations, and weather. PM[sub 10] was a risk factor for pneumonia admissions (relative risk [RR] = 1.17, 95% confidence interval [CI] = 1.33-1.02) and COPD admissions (RR = 1.57, 95% CI = 2.06-1.20). Ozone was also associated with pneumonia admissions (RR = 1.15, 95% CI = 1.36-0.97). The relative risks are for an increase of 100 [mu]g/m[sup 3] in daily PM[sub 10] and 50 ppb in daily ozone concentration. Several alternative methods for controlling for seasonal patterns and weather were used, including nonparametric regression techniques. The results were not sensitive to the methods. When days exceeding the National Ambient Air Quality Standard for either pollutant were excluded, the association remained for both pneumonia (RR = 1.18, 95% CI = 1.34-1.03 for PM[sub 10] and RR = 1.18, 95% CI = 1.41-0.99 for ozone) and COPD (RR = 1.54, 95% CI = 2.06-1.16 for PM[sub 10]). 48 refs., 6 figs., 5 tabs.« less

  12. An Overview of the Project on the Imaging and Full-Text Retrieval of the Ava Helen and Linus Pauling Papers at the Oregon State University Libraries.

    ERIC Educational Resources Information Center

    Krishnamurthy, Ramesh S.; Mead, Clifford S.

    1995-01-01

    Presents plan of Oregon State University Libraries to convert all paper documents from the Ava Helen and Linus Pauling archives to digital format. The scope, goals, tasks and objectives set by the project coordinators are outlined, and issues such as protection of equipment, access, copyright and management are discussed. (JKP)

  13. There Is More Variation "within" than "across" Domains: An Interview with Paul A. Kirschner about Applying Cognitive Psychology-Based Instructional Design Principles in Mathematics Teaching and Learning

    ERIC Educational Resources Information Center

    Kirschner, Paul A.; Verschaffel, Lieven; Star, Jon; Van Dooren, Wim

    2017-01-01

    In this interview we asked Paul A. Kirschner about his comments and reflections regarding the idea to apply cognitive psychology-based instructional design principles to mathematics education and some related issues. With a main focus on cognitive psychology, educational psychology, educational technology and instructional design, this…

  14. Paul Trapping of Radioactive {sup 6}He{sup +} Ions and Direct Observation of Their {beta} Decay

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Flechard, X.; Lienard, E.; Mery, A.

    2008-11-21

    We demonstrate that abundant quantities of short-lived {beta} unstable ions can be trapped in a novel transparent Paul trap and that their decay products can directly be detected in coincidence. Low energy {sup 6}He{sup +} (807 ms half-life) ions were extracted from the SPIRAL source at GANIL, then decelerated, cooled, and bunched by means of the buffer gas cooling technique. More than 10{sup 8} ions have been stored over a measuring period of six days, and about 10{sup 5} decay coincidences between the beta particles and the {sup 6}Li{sup ++} recoiling ions have been recorded. The technique can be extendedmore » to other short-lived species, opening new possibilities for trap assisted decay experiments.« less

  15. [Is there a German history of evidence-based medicine? Methodic standards of therapeutic research in the early 20th century and Paul Martini's "Methodology of therapeutic investigation" (1932)].

    PubMed

    Stoll, S; Roelcke, V; Raspe, H

    2005-07-29

    The article addresses the history of evidence-based medicine in Germany. Its aim was to reconstruct the standard of clinical-therapeutic investigation in Germany at the beginning of the 20 (th) century. By a historical investigation of five important German general medical journals for the time between 1918 and 1932 an overview of the situation of clinical investigation is given. 268 clinical trails are identified, and are analysed in view of their methodological design. Heterogeneous results are found: While few examples of sophisticated methodology exist, the design of the majority of the studies is poor. A response to the situation described can be seen in Paul Martini's book "Methodology of Therapeutic Investigation", first published in 1932. Paul Martini's biography, his criticism of the situation of clinical-therapeutic investigation of his time, the major points of his methodology and the reception of the book in Germany and abroad are described.

  16. Paul Ehrlich and the Early History of Granulocytes.

    PubMed

    Kay, A Barry

    2016-08-01

    Paul Ehrlich's techniques, published between 1879 and 1880, for staining blood films using coal tar dyes, and his method of differential blood cell counting, ended years of speculation regarding the classification of white cells. Acidic and basic dyes had allowed him to recognize eosinophil and basophil granules, respectively, work that was a direct continuation of his discovery of the tissue mast cell described in his doctoral thesis. Ehrlich went on to develop neutral dyes that identified epsilon granules in neutrophils ("cells with polymorphous nuclei"). He also speculated, for the most part correctly, on the formation, function, and fate of blood neutrophils and eosinophils. Before Ehrlich, a number of important observations had been made on white cells and their role in health and disease. Among the most notable were William Hewson's studies of blood and lymph; the early descriptions of leukemia by Alfred Donné, John Hughes Bennett, Rudolf Virchow, and others; as well as seminal observations on inflammation by William Addison, Friedrich von Recklinghausen, and Julius Cohnheim. Eosinophils were almost certainly recognized previously by others. In 1846, Thomas Wharton Jones (1808-1891) described "granule blood-cells" in several species including humans. The term "granule cell" had also been used by Julius Vogel (1814-1880), who had previously observed similar cells in inflammatory exudates. Vogel, in turn, was aware of the work of Gottlieb Gluge (1812-1898), who had observed "compound inflammatory globules" in pus and serum that resembled eosinophils. Almost 20 years before Ehrlich developed his staining methods, Max Johann Schultze (1825-1874) performed functional experiments on fine and coarse granular cells using a warm stage microscopic technique and showed they had amoeboid movement and phagocytic abilities. Despite these earlier observations, it was Ehrlich's use of stains that heralded the modern era of studies of leukocyte biology and pathology.

  17. STS-102 Astronaut Paul Richards Participates in Space Walk

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Astronaut Paul W. Richards, STS-102 mission specialist, works in the cargo bay of the Space Shuttle Discovery during the second of two scheduled space walks. Richards, along with astronaut Andy Thomas, spent 6.5 hours outside the International Space Station (ISS), continuing work to outfit the station and prepare for delivery of its robotic arm. STS-102 delivered the first Multipurpose Logistics Modules (MPLM) named Leonardo, which was filled with equipment and supplies to outfit the U.S. Destiny Laboratory Module. The Leonardo MPLM is the first of three such pressurized modules that will serve as the ISS' moving vans, carrying laboratory racks filled with equipment, experiments, and supplies to and from the Station aboard the Space Shuttle. The cylindrical module is approximately 21-feet long and 15- feet in diameter, weighing almost 4.5 tons. It can carry up to 10 tons of cargo in 16 standard Space Station equipment racks. Of the 16 racks the module can carry, 5 can be furnished with power, data, and fluid to support refrigerators or freezers. In order to function as an attached station module as well as a cargo transport, the logistics module also includes components that provide life support, fire detection and suppression, electrical distribution, and computer functions. NASA's 103rd overall mission and the 8th Space Station Assembly Flight, STS-102 mission also served as a crew rotation flight. It delivered the Expedition Two crew to the Station and returned the Expedition One crew back to Earth.

  18. Family structure and childhood anthropometry in Saint Paul, Minnesota in 1918

    PubMed Central

    Warren, John Robert

    2017-01-01

    Concern with childhood nutrition prompted numerous surveys of children’s growth in the United States after 1870. The Children’s Bureau’s 1918 “Weighing and Measuring Test” measured two million children to produce the first official American growth norms. Individual data for 14,000 children survives from the Saint Paul, Minnesota survey whose stature closely approximated national norms. As well as anthropometry the survey recorded exact ages, street address and full name. These variables allow linkage to the 1920 census to obtain demographic and socioeconomic information. We matched 72% of children to census families creating a sample of nearly 10,000 children. Children in the entire survey (linked set) averaged 0.74 (0.72) standard deviations below modern WHO height-for-age standards, and 0.48 (0.46) standard deviations below modern weight-for-age norms. Sibship size strongly influenced height-for-age, and had weaker influence on weight-for-age. Each additional child six or underreduced height-for-age scores by 0.07 standard deviations (95% CI: −0.03, 0.11). Teenage siblings had little effect on height-forage. Social class effects were substantial. Children of laborers averaged half a standard deviation shorter than children of professionals. Family structure and socio-economic status had compounding impacts on children’s stature. PMID:28943749

  19. Aharonov-Bohm effect in the tunnelling of a quantum rotor in a linear Paul trap.

    PubMed

    Noguchi, Atsushi; Shikano, Yutaka; Toyoda, Kenji; Urabe, Shinji

    2014-05-13

    Quantum tunnelling is a common fundamental quantum mechanical phenomenon that originates from the wave-like characteristics of quantum particles. Although the quantum tunnelling effect was first observed 85 years ago, some questions regarding the dynamics of quantum tunnelling remain unresolved. Here we realize a quantum tunnelling system using two-dimensional ionic structures in a linear Paul trap. We demonstrate that the charged particles in this quantum tunnelling system are coupled to the vector potential of a magnetic field throughout the entire process, even during quantum tunnelling, as indicated by the manifestation of the Aharonov-Bohm effect in this system. The tunnelling rate of the structures periodically depends on the strength of the magnetic field, whose period is the same as the magnetic flux quantum φ0 through the rotor [(0.99 ± 0.07) × φ0].

  20. The cestode community in northern fur seals (Callorhinus ursinus) on St. Paul Island, Alaska.

    PubMed

    Kuzmina, Tetiana A; Hernández-Orts, Jesús S; Lyons, Eugene T; Spraker, Terry R; Kornyushyn, Vadym V; Kuchta, Roman

    2015-08-01

    The diversity and ecology of cestodes from the northern fur seals, Callorhinus ursinus (NFS), were examined using newly collected material from 756 humanely harvested subadult males between 2011 and 2014. NFSs were collected from five different haul-outs on St. Paul Island, Alaska. A total of 14,660 tapeworms were collected with a prevalence of 98.5% and intensity up to 107 cestodes per host (mean intensity 19.7 ± 16.5 SD). Three species of tapeworms were found: Adenocephalus pacificus (Diphyllobothriidea) was the most prevalent (prevalence 97.4%), followed by Diplogonoporus tetrapterus (49.7%), and 5 immature specimens of Anophryocephalus cf. ochotensis (Tetrabothriidea) (0.5%). Most of the cestodes found in the NFS were immature (69.7%). However, only 0.9% of cestodes were in larval (plerocercoid) stages. The species composition, prevalence and intensity of cestodes from these NFSs were not statistically different between the five separate haul-outs. Significant increases in the intensity of NFS infections were observed during the study period.

  1. Objectivity, abstraction, and the individual: the influence of Søren Kierkegaard on Paul Feyerabend.

    PubMed

    Kidd, Ian James

    2011-03-01

    This paper explores the influence of Søren Kierkegaard upon Paul Feyerabend by examining their common criticisms of totalising accounts of human nature. Both complained that philosophical and scientific theories of human nature which were methodologically committed to objectivity and abstraction failed to capture the richness of human experience. Kierkegaard and Feyerabend argued that philosophy and the science were threatening to become obstacles to human development by imposing abstract theories of human nature and reality which denied the complexities of both. In both cases, this took the form of asserting an 'existential' criterion for the assessment of philosophical and scientific theories. Kierkegaard also made remarks upon the inappropriateness of applying natural scientific methods to human beings which Feyerabend later expanded and developed in his criticisms of the inability of the 'scientific world-view' to accommodate the values necessary to a flourishing human life. I conclude by noting some differences between Kierkegaard and Feyerabend's positions and by affirming the value of existential criticisms of scientific knowledge.

  2. Southeast Indian Ridge Between the Rodriguez Triple Junction and the Amsterdam and Saint-Paul Islands: Detailed Kinematics for the Past 20 m.y.

    NASA Astrophysics Data System (ADS)

    Royer, Jean-Yves; Schlich, Roland

    1988-11-01

    The Southeast Indian Ridge has the fastest spreading rates of the three mid-oceanic ridge systems of the Indian Ocean and has recorded the movements of Antarctica relative to Australia and India since the Late Cretaceous. New bathymetric and magnetic data have been collected by the R/V Marion Dufresne (1983) and the R/V Jean Charcot (1984), on the western part of this ridge, between the Rodriguez Triple Junction (25.5°S, 70.0°E) and the Amsterdam and Saint-Paul islands (38°S, 78°E). These data bring additional information on the seafloor magnetic pattern produced by the Southeast Indian Ridge during the past 20 m.y. A new tectonic chart is proposed for the area around the Amsterdam and Saint-Paul islands. We have mapped 17 isochrons ranging from anomalies 6 to 1 (20.5-0.7 Ma) based on the compilation of all the data available in this area (25 cruises). Their distribution clearly shows asymmetric features. Reconstructions at short time intervals show that stage poles of rotation describe oscillatory movements along a direction parallel to the Southeast Indian Ridge axis. Observed changes in spreading rates and the stability of the spreading directions since the Miocene support this result.

  3. Conspiracies of immanence: Paul Tillich, Pierre Teilhard de Chardin and C.G. Jung.

    PubMed

    Dourley, John

    2015-02-01

    Jung's psychology proffers a sustained reflection on the traditional religious question of the relation of divine transcendence to immanence. On this issue his psychology affirms a position of radical immanence in its contention that the experience of divinity is initially wholly from within. Though this position remains on the periphery of religious and theological orthodoxy Jung is not alone in holding it among moderns. Paul Tillich adopts a similar stance with his controlling symbols of the divine as 'Ground of Being' and 'Depth of Reason'. Pierre Teilhard de Chardin understands divinity as the experiential energy of evolution itself working within nature and humanity toward greater configurations of universal communion as the basis of community. All of Jung's master symbols of individuation assume such an understanding of immanence uniting individual and totality. His psychology strongly suggests and contributes to the current emergence of a new religious sensitivity based on the awareness of the intra-psychic origin of all religions. In his later writings he held out such a position as a significant alternative to genocide. © 2015, The Society of Analytical Psychology.

  4. A molecular dynamics simulation study on trapping ions in a nanoscale Paul trap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhao, Xiongce; Krstic, Predrag S

    2008-01-01

    We found by molecular dynamics simulations that a low energy ion can be trapped effectively in a nanoscale Paul trap in both vacuum and in aqueous environment when appropriate AC/DC electric fields are applied to the system. Using the negatively charged chlorine ion as an example, we show that the trapped ion oscillates around the center of the nanotrap with the amplitude dependent on the parameters of the system and applied voltage. Successful trapping of the ion within nanoseconds requires electric bias of GHz frequency, in the range of hundreds of mV. The oscillations are damped in the aqueous environment,more » but polarization of the water molecules requires application of the higher voltage biases to reach the improved stability of the trapping. Application of a supplemental DC driving field along the trap axis can effectively drive the ion off the trap center and out of the trap, opening a possibility of studying DNA and other biological molecules using embedded probes while achieving a full control of their translocation and localization in the trap.« less

  5. Earthquake Magnitude Relationships for the Saint Peter and Saint Paul Archipelago, Equatorial Atlantic

    NASA Astrophysics Data System (ADS)

    de Melo, Guilherme W. S.; do Nascimento, Aderson F.

    2018-03-01

    We have investigated several relationships between ML, M(NEIC) and Mw for the earthquakes locally recorded in the Saint Peter and Saint Paul Archipelago (SPSPA), Equatorial Atlantic. Because we only have one station in the area, we could not derive attenuation relations for events recorded at different distances at different stations. Our approach was then to compare our ML estimates with magnitudes reported by NEIC. This approach produced acceptable results particularly for epicentral distance smaller than 100 km. For distances greater that 100 km, there is a systematic increase in the residuals probable due to the lack of station correction and our inability to accurately estimate Q. We also investigate the Mw—M(NEIC) relationship. We find that Mw estimates using S-wave produce smaller residuals when compared with both M(NEIC). Finally, we also investigate the ML—Mw relationship and observe that given the data set we have, the 1:1 holds. We believe that the use of the present methodologies provide consistent magnitude estimates between all the magnitudes investigated that could be used to better assess seismic hazard in the region.

  6. Earthquake Magnitude Relationships for the Saint Peter and Saint Paul Archipelago, Equatorial Atlantic

    NASA Astrophysics Data System (ADS)

    de Melo, Guilherme W. S.; do Nascimento, Aderson F.

    2017-12-01

    We have investigated several relationships between ML, M(NEIC) and Mw for the earthquakes locally recorded in the Saint Peter and Saint Paul Archipelago (SPSPA), Equatorial Atlantic. Because we only have one station in the area, we could not derive attenuation relations for events recorded at different distances at different stations. Our approach was then to compare our ML estimates with magnitudes reported by NEIC. This approach produced acceptable results particularly for epicentral distance smaller than 100 km. For distances greater that 100 km, there is a systematic increase in the residuals probable due to the lack of station correction and our inability to accurately estimate Q. We also investigate the Mw—M(NEIC) relationship. We find that Mw estimates using S-wave produce smaller residuals when compared with both M(NEIC). Finally, we also investigate the ML—Mw relationship and observe that given the data set we have, the 1:1 holds. We believe that the use of the present methodologies provide consistent magnitude estimates between all the magnitudes investigated that could be used to better assess seismic hazard in the region.

  7. The Age of Miracle and Wonders: Paul Simon and the Changing American Dream.

    PubMed

    Fuchsman, Ken

    2016-01-01

    The American dream altered. In the 19th century, it was focused on male success in the marketplace. With the rise of the consumer culture, ideals changed. Women were brought in, as companionate marriage, home ownership, and a successful domestic life with children became central in American life. Since the mid-sixties, singer-songwriter Paul Simon has been writing songs reflecting these changes. He has two songs with America in the title, and is one of the few rock stars that write extensively about marriage and parenting. He also writes about love as romance, with a spouse, and towards offspring. Simon too composes songs about affluence, technology, and what brings happiness and joy. His work illuminates the United States in what he says is "the age's most uncertain hour." He believed that affluence was a key to our fulfillment. The changes in American life since the 1970s, show that much of what was held as ideal, has been through troubled times. We can gain insight into the fate of the American dream through Simon's songs.

  8. An Intergenerational Support System for Child Welfare Families.

    ERIC Educational Resources Information Center

    Harnett, Joan

    1989-01-01

    Describes a program developed by the Children's Aid Society of Montgomery County, Pennsylvania, called Intergenerational Support System (ISS), in which senior volunteers serve as support persons for problem families. (SAK)

  9. A great pioneer of clinical science remembered: introduction to the special issue in honor of Paul E. Meehl.

    PubMed

    Lilienfeld, Scott O; Waller, Niels G

    2005-10-01

    In this special issue, the seminal contributions to clinical psychology of Paul E. Meehl, who passed away in 2003, are commemorated. The nine articles comprising this special issue chronicle Meehl's remarkable intellectual biography and examine his influence on diverse domains of psychology, including the clinical versus actuarial prediction debate, the cognitive activity of the clinician, personality assessment and trait theory, the etiology of schizophrenia, the shortcomings of statistical significance testing, and the use of metascientific methods to evaluate competing models of human nature. These articles illustrate not only Meehl's legendary brilliance but also his pivotal role in forcing clinical psychologists to think more clearly and incisively about their subject matter. 2005 Wiley Periodicals, Inc.

  10. The role of climate and vegetation on woolly mammoth extinction on St. Paul Island, Alaska and megafauna extinction in North America in the late Quaternary

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Porter, W.; Miller, P. A.; Graham, R. W.; Williams, J. W.

    2016-12-01

    Estimate of megafauna behaviors dynamically under associated environmental factors is important to understand the mechanisms and causes of the late Quaternary megafaunal extinctions. On St. Paul Island, an isolated remnant of the Bering Land Bridge, a late-surviving population of woolly mammoth (Mammuthus primigenius) persisted until 5,600 cal BP, while 37 out of 54 megafauna species in the continent of North America, all herbivores, went extinct at the end of Pleistocene between 13,800 and 11,500 cal BP. Proposed natural drivers of the extinction events include abrupt temperature changes, food resource loss and freshwater shortage. Here we tested these three hypothesized mechanisms, using a physiological model (Niche Mapper) to estimate individual megafauna behaviors from the perspectives of metabolic rate, individual vegetation and freshwater requirement under simulated climates from Community Climate System Model version 3 (CCSM3), vegetation reconstructions based on dynamic LPJ-GUESS model and woolly mammoth and megafauna species trait data reconstructed based on mammal fossils. Preliminary simulations of woolly mammoth on St. Paul Island point to the importance of net vegetation primary productivity and freshwater availability as limits on the carrying capacity of St. Paul for mammoth populations, with a low carrying capacity in the middle Holocene making this population highly vulnerable to extinction. Results also indicate that the abrupt warming based around 14,000 cal BP in Bering land bridge on CCSM3 simulations causes woolly mammoth extinction, by driving metabolic rate high up beyond the active basic metabolic rate. Analysis suggests a positive relationship between temperature and metabolic rate, and woolly mammoth would go extinct when summer temperature is up to 12 °C or higher. However the temperature reconstructed based on regional proxies is relatively stable compared to CCSM3 simulations, and leads to stable metabolic rate of woolly mammoth and

  11. Paul Hagenmüller's contribution to solid state chemistry: A scientometric analysis

    NASA Astrophysics Data System (ADS)

    El Aichouchi, Adil; Gorry, Philippe

    2018-06-01

    Paul Hagenmüller (1921-2017) is an important figure of French solid-state chemistry, who enjoyed scientific and institutional recognition. He published 796 papers and has been cited more than 16,000 times. This paper explores Hagenmüller's work using scientometric analysis to reveal the impact of his work, his main research topics and his collaborations. Although Hagenmüller was a recognized scientist, a subset of his work, now highly cited, attracted little attention at the time of publication. To understand this phenomenon, we detect and study papers with delayed recognition, also called 'Sleeping Beauties' (SBs). In scientometrics, SBs are publications that go unnoticed, or 'sleep' for a long time before suddenly attracting a lot of attention in terms of citations. We identify 7 SBs published between 1965 and 1985, and awakened between 1993 and 2010. The first SB reports the discovery of the clathrate structure of silicon. The second reports the isolation of four new phases with the formula NaxCoO2 (x < =1). The five other SBs investigate the electrochemical intercalation and deintercalation of sodium, and the structure and properties of layered oxides. Through interviews with his coworkers, we attempt to identify the reasons for the delayed recognition and the context of the renewed interest in those papers.

  12. Pope John Paul II apologizes for church's oppression of women.

    PubMed

    1995-01-01

    In a 16-page letter which is widely viewed by women's groups as an effort to win support for the Vatican's position at the upcoming UN Conference on Women in Beijing, Pope John Paul II apologizes to women throughout the world for the church's historic complicity in their oppression. Although phrased in general terms, the letter contains language and ideas of a far more feminist tone than any previous statements or declarations made by the Pontiff. Calling for increased respect for women and sensitivity to their needs, the letter also claims that "there is an urgent need to achieve real equality in every area: equal pay for equal work, protection for working mothers, fairness in career advancements, equality of spouses with regard to family rights and recognition of everything that is part of the rights and duties of citizens in a democratic state." Recognizing women's significant achievements and sacrifices inside and outside of the home, the Pope expressed admiration for "those women of good will who have devoted their lives to defending the dignity of womanhood by fighting for their basic social, economic and political rights, demonstrating courageous initiative at a time when this was considered extremely inappropriate, the sign of a lack of femininity, a manifestation of exhibitionism, and even a sin." Although the letter heralds a new awareness in the Vatican of women's views, concerns and grievances, the Pope has not signaled any dramatic changes in official church policy: women's ordination, divorce, abortion and birth control are still considered beyond the pale of acceptability. full text

  13. Seafloor spreading on the Amsterdam-St. Paul hotspot plateau

    NASA Astrophysics Data System (ADS)

    Conder, James A.; Scheirer, Daniel S.; Forsyth, Donald W.

    2000-04-01

    The Amsterdam-St. Paul (ASP) platform on the intermediate rate Southeast Indian Ridge (SEIR) is the only oceanic hotspot plateau outside the Atlantic Ocean containing an active, mid-ocean ridge spreading axis. Because the ASP hotspot is small and remotely located, it has been relatively unstudied, and the ridge axis location in many places near the ASP plateau was previously unknown or ambiguous. We mapped the SEIR out to 1 Ma crust (Jaramillo anomaly) both on and near the ASP platform. We located the spreading center to within a few kilometers, based on side-scan sonar reflectivity. Recent off-platform magnetic anomalies and lineated abyssal hill topography are consistent with a simple spreading history. Off-platform full spreading rates increase from ˜63 km/Myr on segment H to the north of the platform to ˜65.5 km/Myr on segment K to the south. In contrast, inversions of seafloor magnetization based on uniform and variable thickness magnetic source layers reflect a complex on-platform tectonic history with ridge jumps, off-axis volcanism, and propagating rifts. On one section of the ASP plateau the spreading location has stabilized and is beginning to rift the plateau apart, generating symmetric magnetic anomalies and lineated topography for the last several hundred thousand years. The larger, more stable, spreading segments of the ASP platform are aligned with major volcanic edifices, suggesting that along-axis magma flow away from plume-fed centers is an important influence on spreading geometry. Many complex tectonic features observed on the ASP plateau, such as ridge jumps, en echelon, oblique spreading centers, and transforms oblique to the spreading direction, are comparable to features observed on Iceland. The similarities suggest that moderate crustal thickening at an intermediate rate spreading center may have similar effects to pronounced thickening at a slow rate spreading center.

  14. [Ilya Ilich Metchnikov and Paul Ehrlich: 1908 Nobel Prize winners for their research on immunity].

    PubMed

    Lokaj, J; John, C

    2008-11-01

    The Nobel Prize in Physiology or Medicine in 1908 was awarded to Ilya I. Mechnikov and Paul Ehrlich for recognition of their work on immunity. Mechnikov have discovered phagocytes and phagocytosis as the basis of natural cellular immunity. His ,,phagocytic theory" is the principle of immunological concept "self and not self" as the prerequisition of physiological inflammation, and selfmaintaining of organism. Ehrlich developed the methods for standardization of antibody activity in immune sera, described neutralizing and complement-depending effect of antibodies and enunciated the ,"ide-chain" theory of the formation of antibodies. Their concept of the key-stone of immunity was different, but they expressed the basic paradigma of immunology: immunity imply the protection of identity and guarantee the integrity of organism. Both are the founders of immunology as the scientific discipline. Discoveries and conceptions of I. Mechnikov and P. Ehrlich exceedingly influenced development of immunology and are also applicable, instructive and suggestive in contemporary immunology and microbiology.

  15. The cestode community in northern fur seals (Callorhinus ursinus) on St. Paul Island, Alaska

    PubMed Central

    Kuzmina, Tetiana A.; Hernández-Orts, Jesús S.; Lyons, Eugene T.; Spraker, Terry R.; Kornyushyn, Vadym V.; Kuchta, Roman

    2015-01-01

    The diversity and ecology of cestodes from the northern fur seals, Callorhinus ursinus (NFS), were examined using newly collected material from 756 humanely harvested subadult males between 2011 and 2014. NFSs were collected from five different haul-outs on St. Paul Island, Alaska. A total of 14,660 tapeworms were collected with a prevalence of 98.5% and intensity up to 107 cestodes per host (mean intensity 19.7 ± 16.5 SD). Three species of tapeworms were found: Adenocephalus pacificus (Diphyllobothriidea) was the most prevalent (prevalence 97.4%), followed by Diplogonoporus tetrapterus (49.7%), and 5 immature specimens of Anophryocephalus cf. ochotensis (Tetrabothriidea) (0.5%). Most of the cestodes found in the NFS were immature (69.7%). However, only 0.9% of cestodes were in larval (plerocercoid) stages. The species composition, prevalence and intensity of cestodes from these NFSs were not statistically different between the five separate haul-outs. Significant increases in the intensity of NFS infections were observed during the study period. PMID:26101743

  16. Miniaturized system of a gas chromatograph coupled with a Paul ion trap mass spectrometer

    NASA Technical Reports Server (NTRS)

    Shortt, B. J.; Darrach, M. R.; Holland, Paul M.; Chutjian, A.

    2005-01-01

    Miniature gas chromatography (GC) and miniature mass spectrometry (MS) instrumentation has been developed to identify and quantify the chemical compounds present in complex mixtures of gases. The design approach utilizes micro-GC components coupled with a Paul quadrupole ion trap (QIT) mass spectrometer. Inherent to the system are high sensitivity, good dynamic range, good QIT resolution, low GC flow-rates to minimize vacuum requirements and the need for consumables; and the use of a modular approach to adapt to volatile organic compounds dissolved in water or present in sediment. Measurements are reported on system response to gaseous species at concentrations varying over four orders of magnitude. The ability of the system to deal with complicated mixtures is demonstrated, and future improvements are discussed. The GC/QIT system described herein has a mass, volume and power that are, conservatively, one-twentieth of those of commercial off-the-shelf systems. Potential applications are to spacecraft cabin-air monitoring, robotic planetary exploration and trace-species detection for residual gas analysis and environmental monitoring.

  17. On the making of a system theory of life: Paul A Weiss and Ludwig von Bertalanffy's conceptual connection.

    PubMed

    Drack, Manfred; Apfalter, Wilfried; Pouvreau, David

    2007-12-01

    In this article, we review how two eminent Viennese system thinkers, Paul A Weiss and Ludwig von Bertalanffy, began to develop their own perspectives toward a system theory of life in the 1920s. Their work is especially rooted in experimental biology as performed at the Biologische Versuchsanstalt, as well as in philosophy, and they converge in basic concepts. We underline the conceptual connections of their thinking, among them the organism as an organized system, hierarchical organization, and primary activity. With their system thinking, both biologists shared a strong desire to overcome what they viewed as a "mechanistic" approach in biology. Their interpretations are relevant to the renaissance of system thinking in biology--"systems biology." Unless otherwise noted, all translations are our own.

  18. Anisakids (Nematoda: Anisakidae) from stomachs of northern fur seals (Callorhinus ursinus) on St. Paul Island, Alaska: parasitological and pathological analysis.

    PubMed

    Kuzmina, T A; Lyons, E T; Spraker, T R

    2014-12-01

    Anisakid nematodes parasitize the alimentary tracts of aquatic vertebrates, including northern fur seals (Callorhinus ursinus) (NFS). The main purpose of this study was to estimate the prevalence, intensity, and species composition of anisakids in NFSs on St. Paul Island, Alaska, and to analyze changes in NFS infection with these nematodes during the last decades. The study was carried out on St. Paul Island, Alaska, in July-August 2011-2013. Stomachs of 443 humanely harvested NFS males were collected from five separate haul-out areas. A total of 4,460 anisakid specimens were collected and identified by morphological criteria. Gross and histological examinations of stomachs were also performed. The overall prevalence of NFS infection was 91.2%; overall mean intensity 10.9, and overall median intensity 6. Five species, Anisakis simplex s. l., Contracaecum osculatum s. l., Pseudoterranova decipiens s. l., P. azarazi and Phocascaris cystophorae, were found. The prevalence of Anisakis was 46.5%, its intensity 7.5. The prevalence and intensity of Contracaecum, Pseudoterranova, and Phocascaris were 33.6% and 3.5, 81.9% and 6.5, and 5.2% and 1.7, respectively. Significant differences in the prevalence of NFS infection were observed between separate haul-outs. Comparison of the present data with the results of studies performed in the North Pacific in the 1960s, showed a significant decrease in the intensity of NFS infection with anisakids during the last decades. The prevalence of mucosal lesions in NFS stomachs caused by anisakids also decreased from 92 to 20.9%. Possible reasons for the changes in NFS infection with anisakids are discussed.

  19. Environmental Assessment of the Construction of the Joint Use Small Arms Range for the 934th Airlift Wing at Minneapolis-St. paul International Airport Air Reserve Station, Minnesota

    DTIC Science & Technology

    2006-10-01

    maintenance, off-aircraft engine testing, miscellaneous chemical usage, and dust collectors. Air quality emissions inventories for Minneapolis-St. Paul...applicable. Contractor responsibilities are to review potentially hazardous workplaces; to monitor exposure to workplace chemical (e.g., asbestos...perform occupational health physicals for those workers subject to any accidental chemical exposures or engaged in hazardous waste work. There are

  20. The use of cosmic-ray muons in the energy calibration of the Beta-decay Paul Trap silicon-detector array

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hirsh, T. Y.; Perez Galvan, A.; Burkey, M.

    This article presents an approach to calibrate the energy response of double-sided silicon strip detectors (DSSDs) for low-energy nuclear-science experiments by utilizing cosmic-ray muons. For the 1-mm-thick detectors used with the Beta-decay Paul Trap, the minimum-ionizing peak from these muons provides a stable and time-independent in situ calibration point at around 300 keV, which supplements the calibration data obtained above 3 MeV from sources. The muon-data calibration is achieved by comparing experimental spectra with detailed Monte Carlo simulations performed using GEANT4 and CRY codes. This additional information constrains the calibration at lower energies, resulting in improvements in quality and accuracy.

  1. Influence of increasing chlorine content on the accumulation and metabolism of polychlorinated biphenyls (PCBs) by Paul's Scarlet rose cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Groeger, A.G.; Fletcher, J.S.

    1988-01-01

    Four radiolabeled congeners of biphenyls with increasing chlorine content (biphenyl; 1-monochlorobiphenyl; 2,2',4,4'-tetrachlorobiphenyl; and 2,2',4,4',5,5'-hexachlorobiphenyl) were provided to suspension cultures of rose (Rosa sp. vc. Paul's Scarlet) for four days. Both the kinetics of (14)C exchange between the cells and medium, and the metabolism of the parent compounds depended on the chlorine content of the congeners. Analysis of both the cells and their medium showed that of the recovered radioactivity 88%, 86%, and 3% of the biphenyl, 1-PCB, and 2,2',4,4'-PCB were metabolized respectively to polar and insoluble residue products. The 2,2',4,4',5,5'-PCB did not appear to be metabolized.

  2. The use of cosmic-ray muons in the energy calibration of the Beta-decay Paul Trap silicon-detector array

    NASA Astrophysics Data System (ADS)

    Hirsh, T. Y.; Pérez Gálvan, A.; Burkey, M. T.; Aprahamian, A.; Buchinger, F.; Caldwell, S.; Clark, J. A.; Gallant, A. T.; Heckmaier, E.; Levand, A. F.; Marley, S. T.; Morgan, G. E.; Nystrom, A.; Orford, R.; Savard, G.; Scielzo, N. D.; Segel, R.; Sharma, K. S.; Siegl, K.; Wang, B. S.

    2018-04-01

    This article presents an approach to calibrate the energy response of double-sided silicon strip detectors (DSSDs) for low-energy nuclear-science experiments by utilizing cosmic-ray muons. For the 1-mm-thick detectors used with the Beta-decay Paul Trap, the minimum-ionizing peak from these muons provides a stable and time-independent in situ calibration point at around 300 keV, which supplements the calibration data obtained above 3 MeV from α sources. The muon-data calibration is achieved by comparing experimental spectra with detailed Monte Carlo simulations performed using GEANT4 and CRY codes. This additional information constrains the calibration at lower energies, resulting in improvements in quality and accuracy.

  3. Earliest depiction of vitiligo in "Venus at a Mirror" (1615) by Peter Paul Rubens (1577-1640).

    PubMed

    Ashrafian, Hutan

    2018-06-01

    The 1615 painting of Venus at a Mirror by Peter Paul Rubens is considered a powerful example of the Flemish Baroque movement. Recently it has been identified that the Venus character in the image has a goitre, however on studying the image further, I note dermato-pathology in another of the painting's main characters; the dark-skinned female typically described as the Venus' maidservant who clearly demonstrates patches of skin pigment loss on her face and neck with a concurrent streak of white hair. Together these suggest the underlying diagnosis of vitiligo. There is also a goitre in this individual suggesting thyroid disease. This new finding may offer additional insight into the historical epidemiology of disease in northern Europe but also offers further understanding of the method, origin, and pathological associations of this prominent painting from a genius artist. © 2017 Wiley Periodicals, Inc.

  4. Study of Nonlinear Dynamics of Intense Charged Particle Beams in the Paul Trap Simulator Experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Hua

    The Paul Trap Simulator Experiment (PTSX) is a compact laboratory device that simulates the nonlinear dynamics of intense charged particle beams propagating over a large distance in an alternating-gradient magnetic transport system. The radial quadrupole electric eld forces on the charged particles in the Paul Trap are analogous to the radial forces on the charged particles in the quadrupole magnetic transport system. The amplitude of oscillating voltage applied to the cylindrical electrodes in PTSX is equivalent to the quadrupole magnetic eld gradient in accelerators. The temporal periodicity in PTSX corresponds to the spatial periodicity in magnetic transport system. This thesismore » focuses on investigations of envelope instabilities and collective mode excitations, properties of high-intensity beams with significant space-charge effects, random noise-induced beam degradation and a laser-induced-fluorescence diagnostic. To better understand the nonlinear dynamics of the charged particle beams, it is critical to understand the collective processes of the charged particles. Charged particle beams support a variety of collective modes, among which the quadrupole mode and the dipole mode are of the greatest interest. We used quadrupole and dipole perturbations to excite the quadrupole and dipole mode respectively and study the effects of those collective modes on the charge bunch. The experimental and particle-in-cell (PIC) simulation results both show that when the frequency and the spatial structure of the external perturbation are matched with the corresponding collective mode, that mode will be excited to a large amplitude and resonates strongly with the external perturbation, usually causing expansion of the charge bunch and loss of particles. Machine imperfections are inevitable for accelerator systems, and we use random noise to simulate the effects of machine imperfection on the charged particle beams. The random noise can be Fourier decomposed into

  5. A Comparison of Documentary Approaches: Margaret Bourke-White and Erskine Caldwell, Authors of "You Have Seen Their Faces," and Dorothea Lange and Paul S. Taylor, Authors of "An American Exodus."

    ERIC Educational Resources Information Center

    Hanson, Art

    Two books that use documentary photography to examine social problems--"You Have Seen Their Faces," a 1937 study of Southern sharecroppers by Margaret Bourke-White and Erskine Caldwell, and "An American Exodus," a 1939 examination of the migration of farm families by Dorothea Lange and Paul S. Taylor--are compared in this…

  6. A world in one dimension: Linus Pauling, Francis Crick and the central dogma of molecular biology.

    PubMed

    Strasser, Bruno J

    2006-01-01

    In 1957, Francis Crick outlined a startling vision of life in which the great diversity of forms and shapes of macromolecules was encoded in the one-dimensional sequence of nucleic acids. This paper situates Crick's new vision in the debates of the 1950s about protein synthesis and gene action. After exploring the reception of Crick's ideas, it shows how they differed radically from a different model of protein synthesis which enjoyed wide currency in that decade. In this alternative model, advocated by Linus Pauling and other luminaries, three-dimensional templates directed the folding of proteins. Even though it was always considered somewhat speculative, this theory was supported by a number of empirical results originating in different experimental systems. It was eventually replaced by a model in which the forms and shapes of macromolecules resulted solely from their amino acid sequence, dramatically simplifying the problem of protein synthesis which Crick was attempting to solve in 1957.

  7. Miniaturized GC/MS instrumentation for in situ measurements: micro gas chromatography coupled with miniature quadrupole array and paul ion trap mass spectrometers

    NASA Technical Reports Server (NTRS)

    Holland, P.; Chutjian, A.; Darrach, M.; Orient, O.

    2002-01-01

    Miniaturized chemical instrumentation is needed for in situ measurements in planetary exploration and other spaceflight applications where factors such as reduction in payload requirements and enhanced robustness are important. In response to this need, we are 'continuing to develop miniaturized GC/MS instrumentation which combines chemical separations by gas chromatography (GC) with mass spectrometry (MS) to provide positive identification of chemical compounds in complex mixtures of gases, such as those found in the International Space Station's cabin atmosphere. Our design approach utilizes micro gas chromatography components coupled with either a miniature quadrupole mass spectrometer array (QMSA) or compact, high-resolution Paul ion trap.

  8. Hospitals and Health Maintenance Organizations: An Analysis of the Minneapolis-St. Paul Experience

    PubMed Central

    Morrisey, Michael A.; Gibson, Geoffrey; Ashby, Cynthia S.

    1983-01-01

    Minneapolis-St. Paul is recognized as a prime example of health care competition. Policymakers and others have been asked to look to the Twin Cities as a model upon which to base new competitive initiatives in the health care sector. Yet little is known about the impact of Health Maintenance Organizations (HMOs) on other health care providers. This study examines the effects of the area's seven health maintenance organizations on the local hospital community. Three questions are addressed. First, is the situation in the Twin Cities unique? A comparison of case study findings and the available literature together with hospital data from similarly HMO-penetrated markets suggests that the Twin Cities' hospital market is indeed different. Second, what is the nature of hospital-HMO interaction? The flexibility of contracting apparently allows hospitals to affiliate successfully with an HMO under a variety of service and reimbursement agreements. Third, what effect has HMO activity had on community-wide utilization? While HMO enrollees clearly use fewer hospital days and the trend in the community is toward fewer days, attributing the change to HMOs is difficult. A large portion of the differences between HMO and community-wide utilization levels is attributable to differences in population. PMID:10309856

  9. Precise positioning of an ion in an integrated Paul trap-cavity system using radiofrequency signals

    NASA Astrophysics Data System (ADS)

    Kassa, Ezra; Takahashi, Hiroki; Christoforou, Costas; Keller, Matthias

    2018-03-01

    We report a novel miniature Paul ion trap design with an integrated optical fibre cavity which can serve as a building block for a fibre-linked quantum network. In such cavity quantum electrodynamic set-ups, the optimal coupling of the ions to the cavity mode is of vital importance and this is achieved by moving the ion relative to the cavity mode. The trap presented herein features an endcap-style design complemented with extra electrodes on which additional radiofrequency voltages are applied to fully control the pseudopotential minimum in three dimensions. This method lifts the need to use three-dimensional translation stages for moving the fibre cavity with respect to the ion and achieves high integrability, mechanical rigidity and scalability. Not based on modifying the capacitive load of the trap, this method leads to precise control of the pseudopotential minimum allowing the ion to be moved with precisions limited only by the ion's position spread. We demonstrate this by coupling the ion to the fibre cavity and probing the cavity mode profile.

  10. The ethical implications of Paul Meehl's work on comparing clinical versus actuarial prediction methods.

    PubMed

    Dawes, Robyn M

    2005-10-01

    Paul E. Meehl's work comparing statistical versus actuarial prediction-and the large body of research that followed by others on the same topic-was mainly theoretical and empirical. Meehl also suggested that this work led to a "practical" conclusion, which was quite strong. The author argues that, in addition, it leads to an ethical conclusion, equally strong. Whether the scientific findings are combined with an overarching ethical principle that the best predictions possible should be made for clients, or whether these findings are framed as delineating what can be done for clients-and that clinicians ought not to attempt to do what they cannot-the conclusion is the same. Whenever statistical prediction rules (SPR's) are available for making a relevant prediction, they should be used in preference to intuition. Any modification of these rules should be systematic and subject to the same type of evaluation originally used to assess the SPR's themselves. It is even possible to develop near-optimal rules in new situations. Providing service that assumes that clinicians "can do better" simply based on self-confidence or plausibility in the absence of evidence that they can actually do so is simply unethical. 2005 Wiley Periodicals, Inc.

  11. Recoil ions from the β decay of 134Sb confined in a Paul trap

    NASA Astrophysics Data System (ADS)

    Siegl, K.; Scielzo, N. D.; Czeszumska, A.; Clark, J. A.; Savard, G.; Aprahamian, A.; Caldwell, S. A.; Alan, B. S.; Burkey, M. T.; Chiara, C. J.; Greene, J. P.; Harker, J.; Marley, S. T.; Morgan, G. E.; Munson, J. M.; Norman, E. B.; Orford, R.; Padgett, S.; Galván, A. Perez; Sharma, K. S.; Strauss, S. Y.

    2018-03-01

    The low-energy recoiling ions from the β decay of 134Sb were studied by using the Beta-decay Paul Trap. Using this apparatus, singly charged ions were suspended in vacuum at the center of a detector array used to detect emitted β particles, γ rays, and recoil ions in coincidence. The recoil ions emerge from the trap with negligible scattering, allowing β -decay properties and the charge-state distribution of the daughter ions to be determined from the β -ion coincidences. First-forbidden β -decay theory predicts a β -ν correlation coefficient of nearly unity for the 0- to 0+ transition from the ground state of 134Sb to the ground state of 134Te. Although this transition was expected to have a nearly 100% branching ratio, an additional 17.2(52)% of the β -decay strength must populate high-lying excited states to obtain an angular correlation consistent with unity. The extracted charge-state distribution of the recoiling ions was compared with existing β -decay results and the average charge state was found to be consistent with the results from lighter nuclei.

  12. Targeting the Oxidative Stress Response System of Fungi with Redox-Potent Chemosensitizing Agents

    PubMed Central

    Kim, Jong H.; Chan, Kathleen L.; Faria, Natália C. G.; Martins, M. de L.; Campbell, Bruce C.

    2012-01-01

    The cellular antioxidant system is a target in the antifungal action of amphotericin B (AMB) and itraconazole (ITZ), in filamentous fungi. The sakAΔ mutant of Aspergillus fumigatus, a mitogen-activated protein kinase (MAPK) gene deletion mutant in the antioxidant system, was found to be more sensitive to AMB or ITZ than other A. fumigatus strains, a wild type and a mpkCΔ mutant (a MAPK gene deletion mutant in the polyalcohol sugar utilization system). Complete fungal kill (≥99.9%) by ITZ or AMB was also achieved by much lower dosages for the sakAΔ mutant than for the other strains. It appears msnA, an Aspergillus ortholog to Saccharomyces cerevisiae MSN2 (encoding a stress-responsive C2H2-type zinc-finger regulator) and sakA and/or mpkC (upstream MAPKs) are in the same stress response network under tert-butyl hydroperoxide (t-BuOOH)-, hydrogen peroxide (H2O2)- or AMB-triggered toxicity. Of note is that ITZ-sensitive yeast pathogens were also sensitive to t-BuOOH, showing a connection between ITZ sensitivity and antioxidant capacity of fungi. Enhanced antifungal activity of AMB or ITZ was achieved when these drugs were co-applied with redox-potent natural compounds, 2,3-dihydroxybenzaldehyde, thymol or salicylaldehyde, as chemosensitizing agents. We concluded that redox-potent compounds, which target the antioxidant system in fungi, possess a chemosensitizing capacity to enhance efficacy of conventional drugs. PMID:22438852

  13. Genome comparisons of two Taiwanese community-associated methicillin-resistant Staphylococcus aureus ST59 clones support the multi-origin theory of CA-MRSA.

    PubMed

    Feng, Ye; Chen, Hsiu-Ling; Chen, Chih-Jung; Chen, Chyi-Liang; Chiu, Cheng-Hsun

    2017-10-01

    Sequence type (ST) 59 is an epidemic lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Asia. Two ST59 clones are prevalent in Taiwan: the Taiwan clone (TW) causes severe infections, whereas the Asian-Pacific clone (AP) is usually commensal. In this study, we sequenced the genome and transcriptome of the representative strains of these two clones and found their differences to focus on three mobile genetic elements: TW carries SCCmec Type V T , Panton-Valentine leucocidin (PVL)-encoding prophage ΦSa2, whereas AP carries SCCmec Type IV and staphylokinase (SAK)-encoding prophage ΦSa3. The anti-virulent role of SAK was confirmed using murine skin and bloodstream infection models. ΦSa3 usually integrates into the hlb gene, but in AP was found to be integrated at the genomic island νSaβ. The mutation of the attB site "TGTATCCAAACTGG" to "TGTATCCGAATTGG" led to a failure in the integration of ΦSa3 in hlb, prompting atypical integration at other sites. The sak gene possessed remarkably different patterns of distribution among the different STs of S. aureus. We conclude that the atypical integration of ΦSa3 may help S. aureus adapt to the human host habitat and that the subsequent loss of ΦSa3 contributes toward the development of a virulent CA-MRSA lineage for wider horizontal transmission. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. A conversation with Paul Greengard. Interview by Eric J Nestler.

    PubMed

    Greengard, Paul

    2013-01-01

    Paul Greengard was born in New York City in 1925. After completing high school, he served three years in the US Navy during World War II and then completed his bachelor's degree at Hamilton College where he majored in physics and mathematics. He obtained a PhD in biophysics from Johns Hopkins University in 1953 and pursued postdoctoral training with Wilhelm Feldberg at the National Institute for Medical Research in England. After eight years as head of biochemistry at Geigy, and sabbaticals at Albert Einstein College of Medicine and Vanderbilt University, he joined the Yale University faculty as a full professor of pharmacology in 1968. While he was at Yale, Greengard's laboratory performed groundbreaking research, which demonstrated a role for cyclic nucleotides, protein kinases and protein phosphatases, and their protein substrates in the regulation of synaptic transmission. In 1983, Greengard moved to The Rockefeller University, where he has since served as the Vincent Astor Professor and Head of the Laboratory of Molecular and Cellular Neuroscience. Greengard's paradigm-shifting research has continued at Rockefeller and has informed our understanding and possible treatment of a host of brain disorders, including schizophrenia, Alzheimer's disease, Parkinson's disease, and depression. He is the author of more than 950 research articles and reviews. Greengard has received numerous awards and honors, including the Nobel Prize in Physiology or Medicine in 2000, the Metropolitan Life Foundation Award for Medical Research, The National Academy of Sciences Award in Neuroscience, the Ralph W. Gerard Prize in Neuroscience for the Society for Neuroscience, and the Karolinska Institutet's Bicentennial Gold Medal. He is a member of the US National Academy of Sciences and the Institute of Medicine of the National Academies. The following interview was conducted on May 29, 2012.

  15. Challenges in Utilising Key Leader Engagement in Civil-Military Operations

    DTIC Science & Technology

    2011-06-01

    experience from Afghanistan represented different organisations: Swedish Armed Forces (SwAF), Swedish International Development Cooperation Agency ( Sida ...with Swedish civil and military personnel • Extensive experience from several missions, focus on Afghanistan • Organisations: SwAF, Sida , SAK and

  16. Publications - GMC 150 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    with gas chromatograms mass spectroscopy data of samples from the following 4 wells: Itkillik River spectroscopy data of samples from the following 4 wells: Itkillik River Unit #1, KRU W. Sak #26, Toolik Fed #2

  17. Pope John Paul II and the neurological standard for the determination of death: A critical analysis of his address to the Transplantation Society

    PubMed Central

    2017-01-01

    The introduction of the “brain death” criterion constitutes a significant paradigm shift in the determination of death. The perception of the public at large is that the Catholic Church has formally endorsed this neurological standard. However, a critical reading of the only magisterial document on this subject, Pope John Paul II’s 2000 address, shows that the pope’s acceptance of the neurological criterion is conditional in that it entails a twofold requirement. It requires that certain medical presuppositions of the neurological standard are fulfilled, and that its philosophical premise coheres with the Church’s teaching on the body-soul union. This article demonstrates that the medical presuppositions are not fulfilled, and that the doctrine of the brain as the central somatic integrator of the body does not cohere either with the current holistic understanding of the human organism or with the Church’s Thomistic doctrine of the soul as the form of the body. Summary The concept of “brain death” (the neurological basis for legally declaring a person dead) has caused much controversy since its inception. In this regard, it has been generally perceived that the Catholic Church has officially affirmed the “brain death” criterion. The address of Pope John Paul II in 2000 shows, however, that he only gave it a conditional acceptance, one which requires that several medical and philosophical presuppositions of the “brain death” standard be fulfilled. This article demonstrates, taking into consideration both the empirical evidence and the Church’s Thomistic anthropology, that the presuppositions have not been fulfilled. PMID:28698708

  18. ON THE MAKING OF A SYSTEM THEORY OF LIFE: PAUL A WEISS AND LUDWIG VON BERTALANFFY’S CONCEPTUAL CONNECTION

    PubMed Central

    Drack, Manfred; Apfalter, Wilfried; Pouvreau, David

    2010-01-01

    In this article, we review how two eminent Viennese system thinkers, Paul A Weiss and Ludwig von Bertalanffy, began to develop their own perspectives toward a system theory of life in the 1920s. Their work is especially rooted in experimental biology as performed at the Biologische Versuchsanstalt, as well as in philosophy, and they converge in basic concepts. We underline the conceptual connections of their thinking, among them the organism as an organized system, hierarchical organization, and primary activity. With their system thinking, both biologists shared a strong desire to overcome what they viewed as a “mechanistic” approach in biology. Their interpretations are relevant to the renaissance of system thinking in biology—“systems biology.” Unless otherwise noted, all translations are our own. PMID:18217527

  19. Obituary: Damon Paul Simonelli, 1959-2004

    NASA Astrophysics Data System (ADS)

    Buratti, Bonnie Jean; Veverka, Joseph

    2005-12-01

    Damon Paul Simonelli died unexpectedly on 1 December 2004 after he collapsed of heart failure at his home near Pasadena, California. Damon led pioneering studies in the scientific exploration of the satellites of the Solar System with spacecraft. He was a longtime member of the AAS's Division for Planetary Sciences community. Only two weeks before his death he attended the 2004 DPS meeting in Louisville where he presented a paper on the surface roughness of Phoebe based on Cassini observations. Damon was born in the Bronx, New York, on 15 August 1959. His father, Aldo Simonelli (d. 1990), was a clarinetist for the New York City Opera Company, and his mother, Alice Kennard Simonelli, was a secretary. His parents met while they were both students at the Julliard School. Family history has it that Damon's mother was an opera student, but she ruined her voice after singing when she had the flu. By junior high school, Damon had become a master at convincing his mother to wake him up at 3 AM to watch televised moonwalks, and to allow the entire family to view Star Trek episodes at the dinner table. Damon graduated from the Bronx High School of Science in 1976, with a composition on the New York State Regents exam that mentioned the significance of bicentennial toilet bowl lids. In addition to placing great emphasis on humor, the Simonelli family valued education. Damon's younger sister Danelle graduated from Vassar College and has served many years as a U. S. Park Ranger at Liberty Island. Damon graduated with a BA summa cum laude in physics from Cornell in 1980, where he had begun working with Carl Sagan. Damon had painstakingly gone through all the Viking images to look for any possibility of sentient life on Mars (he didn't find any). Perhaps the arrival of data from the first great explorers of the outer Solar System - Voyagers 1 and 2 - convinced Damon to continue at Cornell with Joe Veverka. While at Cornell, Damon began his pioneering work on the use of

  20. Re-examining Paul Broca's initial presentation of M. Leborgne: understanding the impetus for brain and language research.

    PubMed

    Lorch, Marjorie

    2011-01-01

    The 150th anniversary affords an opportunity to revisit the circumstances surrounding Paul Broca's case report celebrated today as the moment of discovery of aphasia. The proceedings from January to June 1861 of the Paris Society of Anthropology are examined to reconstruct the events surrounding the report of M. Leborgne on April 18th. From a close reading of the presentations and discussions which took place during this period it is apparent that Broca's case report was a minor diversion to a debate about cranial measurements and their relation to intelligence in individuals and racial groups. Moreover, it appears that little attention was granted to Broca's first case at the time. While his ideas about localization and specialization developed and change over the next decade, it represented a minor field of interest for him. Nevertheless Broca's work on aphasia inspired research throughout Europe and North America and went on to have a lasting impact on both aphasiology and neuropsychology. Copyright © 2011 Elsevier Srl. All rights reserved.

  1. Digeneans of northern fur seals Callorhinus ursinus (Pinnipedia: Otariidae) from five subpopulations on St. Paul Island, Alaska.

    PubMed

    Kuzmina, T A; Tkach, V V; Spraker, T R; Lyons, E T; Kudlai, O

    2018-04-01

    A parasitological survey of 651 northern fur seals Callorhinus ursinus L. from five subpopulations was conducted on St. Paul Island, Alaska, during July-August 2012-2014. Digenean trematodes were found in 210 of 651 fur seals with a total prevalence of 32.3%. Intensity of infection varied from 1 to 1540 parasites with mean intensity 18.4 ± 111.1 SD and median intensity of 2 specimens per host. Significant differences in prevalence and intensity of infection in northern fur seals between separate rookeries was not observed (Mann-Whitney test; p > 0.05). Four species of digeneans belonging to the families Heterophyidae (Apophallus zalophi Price, 1932, Phocitrema fusiforme Goto and Ozaki, 1930, and Galactosomum ubelakeri (Dailey, 1969)) and Troglotrematidae (Nanophyetus salmincola (Chapin, 1926)) were found. Nanophyetus salmincola is reported from C. ursinus for the first time. We obtained partial 28S rDNA sequences for all digenean species and conducted molecular phylogenetic analysis to demonstrate their phylogenetic relationships.

  2. From chemotherapy to signal therapy (1909-2009): A century pioneered by Paul Ehrlich.

    PubMed

    Maruta, H

    2009-04-01

    Paul Ehrlich (1854-1915), a German microbiologist who was awarded a 1908 Nobel Prize in Physiology/Medicine for his pioneer work on the antibody production, pioneered the modern chemotherapy by discovering his magic bullet for syphilis, called "606" or "Salvarsan" in 1909 with a Japanese young scientist, Sahachiro Hata (1873-1938) from "Denken" (Institute for Infectious Diseases, now called IMS for Institute for Medical Sciences) in Tokyo. His magic bullet was used to eradicate syphilis for more than a half century until a more safe and effective antibiotic called "Penicillin" was introduced to this world towards the end of WWII by Howard Florey (1898-1968). Celebrating this year the 100th anniversary of his discovery, this brief review will discuss how Ehrlich, now known as the Father of Chemotherapy, managed to design the first effective therapeutic for this then formidable sexually transmitted disease, which is equivalent to AIDS, HIV-infection, in the present century, and how so many new chemotherapeutics have been successfully developed during the past 100 years for other formidable diseases such as cancers and AIDS by his followers (microbe hunters and oncogene hunters) such as Alexander Fleming (1881-1955), Hamao Umezawa (1914-1986) and Brian Druker, culminating in the first signal therapeutics of cancers such as "Gleevec" that block the oncogenic signaling, around the turn of this century.

  3. A low-drift, low-noise, multichannel dc voltage source for segmented-electrode Paul traps

    NASA Astrophysics Data System (ADS)

    Beev, Nikolai; Fenske, Julia-Aileen; Hannig, Stephan; Schmidt, Piet O.

    2017-05-01

    We present the design, construction, and characterization of a multichannel, low-drift, low-noise dc voltage source specially designed for biasing the electrodes of segmented linear Paul traps. The system produces 20 output voltage pairs having a common-mode range of 0 to +120 V with 3.7 mV/LSB (least significant bit) resolution and differential ranges of ±5 V with 150 μV/LSB or ±16 V with 610 μV/LSB resolution. All common-mode and differential voltages are independently controllable, and all pairs share the same ground reference. The measured drift of the voltages after warm-up is lower than 1 LSB peak-to-peak on the time scale of 2 h. The noise of an output voltage measured with respect to ground is <10 μVRMS within 10 Hz-100 kHz, with spectral density lower than 3 nV Hz-1/2 above 50 kHz. The performance of the system is limited by the external commercial multichannel DAC unit NI 9264, and in principle, it is possible to achieve higher stability and lower noise with the same voltage ranges. The system has a compact, modular, and scalable architecture, having all parts except for the DAC chassis housed within a single 19″ 3HE rack.

  4. Paul Klee (1879-1940) as a tragic figure: What the artist learned from his illness.

    PubMed

    Albury, W R; Weisz, G M

    2017-02-01

    Paul Klee was a major contributor to the development of modern European art. An ethnic German (although born in Switzerland) and a German citizen, he was persecuted by the Nazi government on political rather than racial grounds because of his allegedly "degenerate" artistic style. Dismissed from his teaching position, he emigrated to Switzerland in 1933; shortly afterward he became ill with systemic sclerosis and struggled with this condition for the remaining years of his life. Many publications have examined the effect of social rejection and illness on his art, but the present study considers the effect of these adversities on Klee's attitude toward his fellow humans. After being an extreme misanthrope in his early adult years, he developed an attitude of cosmic indifference toward humanity during the First World War, which he then maintained until the end of 1939. Although his rejection by Germany had been a significant emotional blow, it was the physical suffering caused by his illness that led him, at the end of his life, to show compassion toward the suffering of other individuals. In this he was like tragic figures such as King Lear who learned from their great misfortunes to value humanity.

  5. Climatology of Diffusion Potential Classes for Minneapolis-St. Paul.

    NASA Astrophysics Data System (ADS)

    Johnson, Allen B.; Baker, Donald G.

    1997-12-01

    This climatological study reports on the potential for atmospheric diffusion at Minneapolis-St. Paul, Minnesota, cities located in the heart of the North American continent. As such, the results can be considered typical of an urban setting within a continental climate.Data were obtained from a nearly continuous 8-yr record of vertical temperature and wind measurements made on a 152.4-m tower. Temperature lapse rates between 21.3 and 152.4 m were grouped into three stability categories: 1) isothermal-inversion, 2) subadiabatic, and 3) superadiabatic. A subdivision of each was based upon wind speeds of less than 4 m s1 and greater than or equal to 4 m s1, resulting in six classes that were examined according to wind direction, time of day, time of year and, most importantly, the associated synoptic conditions.The isothermal-inversion condition was limited to nighttime periods, especially when high pressure centers were dominant and winds were less than 4 m s1. The highest frequency of occurrence was during midsummer, while the lowest was during late fall and early winter. The subadiabatic condition was primarily a nighttime phenomenon, except for the winter season when it was also common during the day. An interesting feature of the diurnal frequencies was that a morning and evening subadiabatic peak occurred due to the transition between nighttime stable and the daytime unstable conditions. The superadiabatic condition was mainly a daytime phenomenon and dominated the early afternoon period throughout the year.The lowest diffusion potential, a result of very stable air and light winds, occurred during the nighttime period, particularly when under the influence of a high pressure center. Weak to moderate diffusion potential, found to occur with weakly stable air and light to moderate winds, was associated with the perimeter of the high pressure center and also with overcast skies near a low pressure center. This condition normally occurred during the night as well

  6. Relation of Knowledge and Performance in Boys' Tennis: Age and Expertise.

    ERIC Educational Resources Information Center

    McPherson, Sue L.; Thomas, Jerry R.

    1989-01-01

    Examined 10- to 13-year-old boys' development of knowledge structure and sport performance in tennis by comparing skills and knowledge of experts and novices. Experts focused on higher concepts and exhibited greater decision-making ability because of their more highly developed knowledge structure. (SAK)

  7. Being a Professional or Practising Professionally

    ERIC Educational Resources Information Center

    Dyer, Mary A.

    2018-01-01

    Research (Lloyd, E., and E. Hallet. [2010]. "Professionalising the Early Childhood Workforce in England: Work in Progress or Missed Opportunity?" "Contemporary Issues in Early Childhood" 11 (1): 75-788; Saks, M. [2012]. "Defining a Profession: The Role of Knowledge and Expertise." "Professions and…

  8. An Expert System for Environmental Data Management.

    ERIC Educational Resources Information Center

    Berka, Petr; Jirku, Petr

    1995-01-01

    Examines the possibility of using expert system tools for environmental data management. Describes the domain-independent expert system shell SAK and Knowledge EXplorer, a system that learns rules from data. Demonstrates the functionality of Knowledge EXplorer on an example of water quality evaluation. (LZ)

  9. A Plea for the traditional family: Situating marriage within John Paul II's realist, or personalist, perspective of human freedom1

    PubMed Central

    Schumacher, Michele M.

    2014-01-01

    This article is an attempt to defend the rights of the traditional family: not simply against the redefinition of marriage, but more fundamentally against a re-conceptualization of human freedom and human rights. To this end, it contrasts what Saint John Paul II calls an individualistic understanding of freedom and a personalistic notion of the same in order to argue that human freedom is called by the Creator to be in service of, and not in opposition to, the good of the human family. From this perspective—that of the social doctrine of the Catholic Church—it argues for the harmony between natural marriage and the respect of fundamental human rights, and it presents the social dimension of marriage as fundamental with respect to the legal and social protection of the family. PMID:25473131

  10. Paul Ehrenfest, Niels Bohr, and Albert Einstein: Colleagues and Friends

    NASA Astrophysics Data System (ADS)

    Klein, Martin J.

    2010-09-01

    In May 1918 Paul Ehrenfest received a monograph from Niels Bohr in which Bohr had used Ehrenfest's adiabatic principle as an essential assumption for understanding atomic structure. Ehrenfest responded by inviting Bohr, whom he had never met, to give a talk at a meeting in Leiden in late April 1919, which Bohr accepted; he lived with Ehrenfest, his mathematician wife Tatyana, and their young family for two weeks. Albert Einstein was unable to attend this meeting, but in October 1919 he visited his old friend Ehrenfest and his family in Leiden, where Ehrenfest told him how much he had enjoyed and profited from Bohr's visit. Einstein first met Bohr when Bohr gave a lecture in Berlin at the end of April 1920, and the two immediately proclaimed unbounded admiration for each other as physicists and as human beings. Ehrenfest hoped that he and they would meet at the Third Solvay Conference in Brussels in early April 1921, but his hope was unfulfilled. Einstein, the only physicist from Germany who was invited to it in this bitter postwar atmosphere, decided instead to accompany Chaim Weizmann on a trip to the United States to help raise money for the new Hebrew University in Jerusalem. Bohr became so overworked with the planning and construction of his new Institute for Theoretical Physics in Copenhagen that he could only draft the first part of his Solvay report and ask Ehrenfest to present it, which Ehrenfest agreed to do following the presentation of his own report. After recovering his strength, Bohr invited Ehrenfest to give a lecture in Copenhagen that fall, and Ehrenfest, battling his deep-seated self-doubts, spent three weeks in Copenhagen in December 1921 accompanied by his daughter Tanya and her future husband, the two Ehrenfests staying with the Bohrs in their apartment in Bohr's new Institute for Theoretical Physics. Immediately after leaving Copenhagen, Ehrenfest wrote to Einstein, telling him once again that Bohr was a prodigious physicist, and again

  11. REESTABLISHING "THE SOCIAL" IN RESEARCH ON DEMOCRATIC PROCESSES: MID-CENTURY VOTER STUDIES AND PAUL F. LAZARSFELD'S ALTERNATIVE VISION.

    PubMed

    Christensen, Michael

    2015-01-01

    Voter studies conducted in the United States during the first decades after World War II transformed social scientific research on democracy. Especially important were the rapid innovations in survey research methods developed by two prominent research centers at Columbia University and the University of Michigan. This article argues that the Columbia and Michigan voter studies presented two visions for research on democracy. Where the Michigan research produced quantitative measures expressing the 'political behavior' of the electorate, the Columbia studies, and especially Paul F. Lazarsfeld, presented an alternative vision for qualitative research on political choice. Largely ignored by later voter studies, this vision prefigured much contemporary research on democracy that embraces a qualitative or interpretive approach. This article reconstructs Lazarsfeld's alternative vision, describes the institutional context in which scholars disregarded it in favor of formal quantitative models, and argues for its recognition as a forerunner to qualitative research on democratic processes. © 2015 Wiley Periodicals, Inc.

  12. Fathers: A Placement Resource for Abused and Neglected Children?

    ERIC Educational Resources Information Center

    Greif, Geoffrey L.; Zuravin, Susan J.

    1989-01-01

    Investigated 17 custodial and 18 noncustodial fathers of abused or neglected children to determine: (1) how fathers get custody; (2) how situations in which fathers get custody differ from those in which they do not; and (3) the degree to which father placements are satisfactory. (SAK)

  13. Comparing Standard and Selective Degradation DNA Extraction Methods: Results from a Field Experiment with Sexual Assault Kits.

    PubMed

    Campbell, Rebecca; Pierce, Steven J; Sharma, Dhruv B; Shaw, Jessica; Feeney, Hannah; Nye, Jeffrey; Schelling, Kristin; Fehler-Cabral, Giannina

    2017-01-01

    A growing number of U.S. cities have large numbers of untested sexual assault kits (SAKs) in police property facilities. Testing older kits and maintaining current case work will be challenging for forensic laboratories, creating a need for more efficient testing methods. We evaluated selective degradation methods for DNA extraction using actual case work from a sample of previously unsubmitted SAKs in Detroit, Michigan. We randomly assigned 350 kits to either standard or selective degradation testing methods and then compared DNA testing rates and CODIS entry rates between the two groups. Continuation-ratio modeling showed no significant differences, indicating that the selective degradation method had no decrement in performance relative to customary methods. Follow-up equivalence tests indicated that CODIS entry rates for the two methods could differ by more than ±5%. Selective degradation methods required less personnel time for testing and scientific review than standard testing. © 2016 American Academy of Forensic Sciences.

  14. A drift experiment to assess the influence of wind on recovery of oiled seabirds on St Paul Island, Alaska

    USGS Publications Warehouse

    Flint, Paul L.; Fowler, A.C.

    1998-01-01

    We used wooden blocks to estimate the proportion of oiled seabird carcasses that were likely to be recovered on beaches of St Paul Island, Alaska following a near-shore oil spill. We released a total of 302 blocks 6 km north of the island in 1997 at the site of a 17 II 1996 oil spill. We used a paired design and released half the blocks when the winds were onshore and released the second half when the winds were offshore. We systematically searched beaches after the second release to recover blocks. We recovered 93 of 152 (61%) blocks released when winds were onshore but only 1 of 150 (0.7%) blocks released when winds were offshore. Given that winds following the 1996 spill were offshore, we conclude that most birds killed at sea following the 1996 spill were likely not recovered on beaches.

  15. Excitation of transverse dipole and quadrupole modes in a pure ion plasma in a linear Paul trap to study collective processes in intense beams

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gilson, Erik P.; Davidson, Ronald C.; Efthimion, Philip C.

    Transverse dipole and quadrupole modes have been excited in a one-component cesium ion plasma trapped in the Paul Trap Simulator Experiment (PTSX) in order to characterize their properties and understand the effect of their excitation on equivalent long-distance beam propagation. The PTSX device is a compact laboratory Paul trap that simulates the transverse dynamics of a long, intense charge bunch propagating through an alternating-gradient transport system by putting the physicist in the beam's frame of reference. A pair of arbitrary function generators was used to apply trapping voltage waveform perturbations with a range of frequencies and, by changing which electrodesmore » were driven with the perturbation, with either a dipole or quadrupole spatial structure. The results presented in this paper explore the dependence of the perturbation voltage's effect on the perturbation duration and amplitude. Perturbations were also applied that simulate the effect of random lattice errors that exist in an accelerator with quadrupole magnets that are misaligned or have variance in their field strength. The experimental results quantify the growth in the equivalent transverse beam emittance that occurs due to the applied noise and demonstrate that the random lattice errors interact with the trapped plasma through the plasma's internal collective modes. Coherent periodic perturbations were applied to simulate the effects of magnet errors in circular machines such as storage rings. The trapped one component plasma is strongly affected when the perturbation frequency is commensurate with a plasma mode frequency. The experimental results, which help to understand the physics of quiescent intense beam propagation over large distances, are compared with analytic models.« less

  16. Diabetic foot--what can we learn from leprosy? Legacy of Dr Paul W. Brand.

    PubMed

    Boulton, Andrew J M

    2012-02-01

    Leprosy and diabetes, though two very different conditions, may both result in severe loss of sensation in the feet, which are then a great risk of painless injury and ulceration. Seminal observations made by the late Dr Paul W. Brand, a surgeon working with leprosy patients in South India in the mid-20th century, resulted in the subsequent development of treatments to manage insensitive foot ulcers that are today entirely applicable to patients with diabetes. As a consequence of his research, the recognition of the relationship between insensitivity, repetitive pressures and skin breakdown has helped our understanding of the aetiopathogenesis of neuropathic foot lesions in diabetes: the development of the total contact cast and other casting devices to treat such lesions forms the basis of management of diabetic foot lesions with off-loading devices that are widely used in the 21st century in diabetic foot clinics around the world. Moreover, observations by Brand that the foot 'heats up before it breaks down' resulted in more recent research showing that self-skin temperature monitoring might help reduce the incidence of recurrent neuropathic foot ulcers in diabetes. In summary, Brand's understanding of 'the gift of pain' that, when lost, results in the late complications of diabetic neuropathy has guided the prevention, diagnosis and management of diabetic foot problems in the 21st century. Copyright © 2012 John Wiley & Sons, Ltd.

  17. Pauling Electronegativity On/Off Effects Assessed by 13 C and 29 Si NMR Spectroscopic Analysis.

    PubMed

    Benedetti, Michele; De Castro, Federica; Fanizzi, Francesco P

    2017-11-27

    In carbon and silicon tetrahalide compounds, the experimental 13 C and 29 Si NMR chemical-shift values are known to increase or decrease on increasing the overall sum of the ionic radii of the bonded halides Σ(r h ) (normal and inverse halogen dependence (NHD and IHD, respectively)). Herein, we extrapolate the main factors responsible for such NMR chemical shifts. Intriguingly, we found a characteristic value for the overall sum of the Pauling electronegativities of the bonded halides Σ(χ h ), which works as a triggering factor to determine the transition from the NHD to IHD. Below this Σ(χ h ) value, the chemical shift of the central atom was strictly related to only the Σ(r h ) value, thus producing a NHD trend. Conversely, above this value, the chemical shift of the central atom was dependent on both the Σ(r h ) and Σ(χ h ) values, thus producing a IHD trend. A simple model, in which the effect of the Σ(χ h ) value on 13 C and 29 Si NMR chemical shifts is related to an apparent increase in the Σ(r h ) value, is deduced. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Microseismic noise in the Saint Peter and Saint Paul Archipelago, equatorial Atlantic

    NASA Astrophysics Data System (ADS)

    de Queiroz, Daniel É.; do Nascimento, Aderson F.; Schimmel, Martin

    2017-12-01

    Microseismic noise, also known as ambient seismic noise, are continuous vibrations mostly composed of Rayleigh waves pervasively recorded in the mili Hertz to 1 Hz frequency range. Their precise source mechanisms are under investigations and related to atmospheric perturbations and ocean gravity waves. Our purpose is to show the behavior of the microseismic noise recorded in the Saint Peter and Saint Paul Archipelago (SPSPA) with respect to wind intensity and ocean waves height in this region, between the North and South Atlantic Ocean. We have recorded both primary microseisms (PM) 0.04-0.12 Hz and the secondary microseisms (SM) 0.12-0.4 Hz during almost four years (2012-2015) and we used frequency, temporal, spatial and statistical correlation analysis to do qualitative and quantitative analysis with respect to wind speed intensity and significant wave height for the same periods. The results indicate a good correlation between the PM and the SM noise in the region particularly during the winter in the Northern Hemisphere and a poor correlation during the summer. We have also shown that probably most of the PM are generated in the SPSPA itself. We note that the intensity of SM recorded in SPSPA appears to have a seasonal behavior with the summer and winter in the Northern Hemisphere, and seems to influence the correlation between the PM and the SM, suggesting that the sources of the PM and the SM are not related to the same atmospheric event and from different places. PM generation would occur near the SPSPA whilst the SM would have distant sources towards the North Atlantic.

  19. ["Anything goes"?: the implicit dialogue between Paul Feyerabend and two Brazilian researchers, Maurício da Rocha e Silva and Newton Freire-Maia].

    PubMed

    Bastos, Francisco Inácio

    2010-03-01

    The philosopher Paul Feyerabend and Brazilian scientists Maurício da Rocha e Silva and Newton Freire-Maia were contemporaries and lived surrounded by the fundamental dilemnas of science. The anarchist proposal of Feyerabend, then embryonic, was formulated in parallel by Rocha e Silva in his criticism of the scientific method. Two decades later, Feyerabend's ideas seemed implicitly to stimulate Newton Freire-Maia in his reflections on science. The web of interrelationships in the ideas of these three men - who never interacted - touches on central issues for Brazilian science from 1960 to 1980, a period in which the latter is consolidated in a dialogue with the nascent reflection on science and the scientific method in Brazil.

  20. [The systematization of the sciences as a cultural task. Options for an open understanding of culture in Paul Hinneberg's encyclopedia].

    PubMed

    Ziche, Paul

    2008-03-01

    Paul Hinneberg promises, in his multi-volume Kultur der Gegenwart (1906sqq.), to capture the 'culture' of his time in its entirety; only a veritable encyclopedia could be adequate to the task of synthesizing the manifold and disparate tendencies of 'Kultur'. Surprisingly, however, any attempt to make explicit the systematic principles governing his encyclopedic synthesis is missing from his project. It is argued that this--unusual--feature of Hinneberg's Kultur der Gegenwart can itself be understood as a result of typical analyses of 'Kultur' at the turn of the century; culture, as an open, multi-sided, and integrative concept may indeed best be captured in an open system that avoids strict and explicit demarcations. In these respects, the task of capturing Kultur turns out to be closely linked to another task prominent around 1900: that of providing a systematic ordering of the various 'Wissenschaften'.

  1. [Paris 1633--a milestone in the development of modern nursing. Vincent de Paul and the sisterhood of the Daughters of charity].

    PubMed

    Jungnitz, Bernhard

    The development of nursing is analysed from the perspective of its situation in Germany today, and the requirements expected for the next years to come. It becomes apparent that nursing as a profession regulated by the state is a young profession, just some one hundred years old. During the 19th century nursing in Germany was mostly performed by sisterhoods bound to the church and organised as collectives. But it was stimulated and challenged by the development from a philosophically oriented library medicine to a scientifically oriented hospital medicine. Thus its transformation into a profession regulated by the state ended for the time being in 1906. Nursing sisterhoods in Germany were modelled for the French Daughters of Charity that had been planted in 1633 by Vincent de Paul and Louise de Marillac in Paris. Models for this planting are pointed to.

  2. Dynamic stabilization of the magnetic field surrounding the neutron electric dipole moment spectrometer at the Paul Scherrer Institute

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Afach, S.; Fertl, M.; Franke, B., E-mail: beatrice.franke@psi.ch, E-mail: bernhard.lauss@psi.ch

    The Surrounding Field Compensation (SFC) system described in this work is installed around the four-layer Mu-metal magnetic shield of the neutron electric dipole moment spectrometer located at the Paul Scherrer Institute. The SFC system reduces the DC component of the external magnetic field by a factor of about 20. Within a control volume of approximately 2.5 m × 2.5 m × 3 m, disturbances of the magnetic field are attenuated by factors of 5–50 at a bandwidth from 10{sup −3} Hz up to 0.5 Hz, which corresponds to integration times longer than several hundreds of seconds and represent the important timescale for the neutron electric dipole moment measurement.more » These shielding factors apply to random environmental noise from arbitrary sources. This is achieved via a proportional-integral feedback stabilization system that includes a regularized pseudoinverse matrix of proportionality factors which correlates magnetic field changes at all sensor positions to current changes in the SFC coils.« less

  3. Interview with Paul W. Kruse on the Early History of HgCdTe, Conducted on October 22, 1980

    NASA Astrophysics Data System (ADS)

    Reine, Marion B.

    2015-09-01

    This paper presents an interview with Dr Paul W. Kruse (1927-2012) on the early history of the semiconductor alloy mercury cadmium telluride (HgCdTe or Hg1- x Cd x Te) at the Honeywell Corporate Research Center near Minneapolis, Minnesota. Conducted on October 22, 1980, the interview covers two main areas. One area is the story of how the HgCdTe research effort came about at the Honeywell Research Center in the early 1960s, what technical choices were made and when, and what technical challenges were overcome and how. The other area is the organization, culture, environment and personnel at the Honeywell Research Center that made the early HgCdTe research programs so successful. HgCdTe has emerged as the highest-performance, most widely applicable infrared detector material. HgCdTe continues to satisfy a broad variety of advanced military and space applications. It is illustrative to look back on the early history of this remarkable semiconductor alloy to help to understand why its technological development as an infrared detector has been so successful.

  4. Developmental Levels of Processing in Metaphor Interpretation.

    ERIC Educational Resources Information Center

    Johnson, Janice; Pascual-Leone, Juan

    1989-01-01

    Outlines a theory of metaphor that posits varying levels of semantic processing and formalizes the levels in terms of kinds of semantic mapping operators. Predicted complexity of semantic mapping operators was tested using metaphor interpretations of 204 children aged 6-12 years and 24 adults. Processing score increased predictably with age. (SAK)

  5. Altering Depth and Complexity in the Science Curriculum for the Gifted: Results of an Experiment

    ERIC Educational Resources Information Center

    Çalikoglu, Burcu Seher; Kahveci, Nihat Gürel

    2015-01-01

    The Republic of Turkey has developed democratic support for equity in education for groups who have various learning needs (Levent, 2011, p. 89-91). In connection with Turkey's central policy of education, current educational applications have addressed these diverse needs to a certain extent. Sak (2011) drew our attention to the insufficiency of…

  6. Pauling and Corey's alpha-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid disease.

    PubMed

    Armen, Roger S; DeMarco, Mari L; Alonso, Darwin O V; Daggett, Valerie

    2004-08-10

    Transthyretin, beta(2)-microglobulin, lysozyme, and the prion protein are four of the best-characterized proteins implicated in amyloid disease. Upon partial acid denaturation, these proteins undergo conformational change into an amyloidogenic intermediate that can self-assemble into amyloid fibrils. Many experiments have shown that pH-mediated changes in structure are required for the formation of the amyloidogeneic intermediate, but it has proved impossible to characterize these conformational changes at high resolution using experimental means. To probe these conformational changes at atomic resolution, we have performed molecular dynamics simulations of these proteins at neutral and low pH. In low-pH simulations of all four proteins, we observe the formation of alpha-pleated sheet secondary structure, which was first proposed by L. Pauling and R. B. Corey [(1951) Proc. Natl. Acad. Sci. USA 37, 251-256]. In all beta-sheet proteins, transthyretin and beta(2)-microglobulin, alpha-pleated sheet structure formed over the strands that are highly protected in hydrogen-exchange experiments probing amyloidogenic conditions. In lysozyme and the prion protein, alpha-sheets formed in the specific regions of the protein implicated in the amyloidogenic conversion. We propose that the formation of alpha-pleated sheet structure may be a common conformational transition in amyloidosis.

  7. Pauling and Corey's α-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid disease

    PubMed Central

    Armen, Roger S.; DeMarco, Mari L.; Alonso, Darwin O. V.; Daggett, Valerie

    2004-01-01

    Transthyretin, β2-microglobulin, lysozyme, and the prion protein are four of the best-characterized proteins implicated in amyloid disease. Upon partial acid denaturation, these proteins undergo conformational change into an amyloidogenic intermediate that can self-assemble into amyloid fibrils. Many experiments have shown that pH-mediated changes in structure are required for the formation of the amyloidogeneic intermediate, but it has proved impossible to characterize these conformational changes at high resolution using experimental means. To probe these conformational changes at atomic resolution, we have performed molecular dynamics simulations of these proteins at neutral and low pH. In low-pH simulations of all four proteins, we observe the formation of α-pleated sheet secondary structure, which was first proposed by L. Pauling and R. B. Corey [(1951) Proc. Natl. Acad. Sci. USA 37, 251–256]. In all β-sheet proteins, transthyretin and β2-microglobulin, α-pleated sheet structure formed over the strands that are highly protected in hydrogen-exchange experiments probing amyloidogenic conditions. In lysozyme and the prion protein, α-sheets formed in the specific regions of the protein implicated in the amyloidogenic conversion. We propose that the formation of α-pleated sheet structure may be a common conformational transition in amyloidosis. PMID:15280548

  8. An Epigenetic Perspective on the Midwife Toad Experiments of Paul Kammerer (1880-1926).

    PubMed

    Vargas, Alexander O; Krabichler, Quirin; Guerrero-Bosagna, Carlos

    2017-01-01

    Paul Kammerer was the most outstanding neo-Lamarckian experimentalist of the early 20th century. He reported spectacular results in the midwife toad, including crosses of environmentally modified toads with normal toads, where acquired traits were inherited in Mendelian fashion. Accusations of fraud generated a great scandal, ending with Kammerer's suicide. Controversy reignited in the 1970s, when journalist Arthur Koestler argued against these accusations. Since then, others have argued that Kammerer's results, even if real, were not groundbreaking and could be explained by somatic plasticity, inadvertent selection, or conventional genetics. More recently, epigenetics has uncovered mechanisms by which inheritance can respond directly to environmental change, inviting a reanalysis of Kammerer's descriptions. Previous arguments for mere somatic plasticity have ignored the description of experiments showing heritable germ line modification. Alleged inadvertent selection associated with egg mortality can be discarded, since mortality decreased in a single generation, upon repeated exposures. The challenging implications did not escape the attention of Kammerer's noted contemporary, William Bateson, but he reacted with disbelief, thus encouraging fraud accusations. Nowadays, formerly puzzling phenomena can be explained by epigenetic mechanisms. Importantly, Kammerer described parent-of-origin effects, an effect of parental sex on dominance. Epigenetic mechanisms underlie these effects in genomic imprinting and experiments of transgenerational epigenetic inheritance. In the early 20th century, researchers had no reason to link them with the inheritance of acquired traits. Thus, the parent-of-origin effects in Kammerer's experiments specifically suggest authenticity. Ultimate proof should come from renewed experimentation. To encourage further research, we present a model of possible epigenetic mechanisms. © 2016 Wiley Periodicals, Inc.

  9. Biology of Grapsus grapsus (L innaeus, 1758) (Brachyura, Grapsidae) in the Saint Peter and Saint Paul Archipelago, Equatorial Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Freire, A. S.; Pinheiro, M. A. A.; Karam-Silva, H.; Teschima, M. M.

    2011-09-01

    Eleven expeditions were undertaken to the Saint Peter and Saint Paul Archipelago to study the reproductive biology of Grapsus grapsus, providing additional information on limb mutilation and carapace colour. MATURE software was used to estimate morphological maturity, while gonadal analyses were conducted to estimate physiological maturity. The puberty moult took place at larger size in males (51.4 mm of carapace length) than in females (33.8 mm), while physiological maturity occurred at a similar size in males (38.4 mm) and in females (33.4 mm). Above 50 mm, the proportion of red males increased in the population, indicating that functional maturity is also related to colour pattern. Small habitat and high local population density contributed to the high rate of cannibalism. The low diversity of food items, absence of predators of large crabs and high geographic isolation are the determinants of unique behavioural and biological characteristics observed in the G. grapsus population.

  10. Specificity in Transition State Binding: The Pauling Model Revisited

    PubMed Central

    Amyes, Tina L.; Richard, John P.

    2013-01-01

    Linus Pauling proposed that the large rate accelerations for enzymes are due to the high specificity of the protein catalyst for binding the reaction transition state. The observation that stable analogs of the transition states for enzymatic reactions often act as tight-binding binding inhibitors provided early support for this simple and elegant proposal. We review experimental results which support the proposal that Pauling’s model provides a satisfactory explanation for the rate accelerations for many heterolytic enzymatic reactions through high energy reaction intermediates, such as proton transfer and decarboxylation. Specificity in transition state binding is obtained when the total intrinsic binding energy of the substrate is significantly larger than the binding energy observed at the Michaelis complex. The results of recent studies to characterize the specificity in binding of the enolate oxygen at the transition state for the 1,3-isomerization reaction catalyzed by ketosteroid isomerase are reviewed. Interactions between pig heart succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) and the nonreacting portions of CoA are responsible for a rate increase of 3 × 1012-fold, which is close to the estimated total 5 × 1013-fold enzymatic rate acceleration. Studies that partition the interactions between SCOT and CoA into their contributing parts are reviewed. Interactions of the protein with the substrate phosphodianion group provide a ca. 12 kcal/mol stabilization of the transition state for the reactions catalyzed by triosephosphate isomerase, orotidine 5′-monophosphate decarboxylase and α-glycerol phosphate dehydrogenase. The interactions of these enzymes with the substrate piece phosphite dianion provide a 6 – 8 kcal/mol stabilization of the transition state for reaction of the appropriate truncated substrate. Enzyme activation by phosphite dianion reflects the higher dianion affinity for binding to the enzyme-transition state complex compared

  11. Euthanasia and John Paul II's "silent language of profound sharing of affection:" why Christians should care about Peter Singer.

    PubMed

    Jeffreys, Derek S

    2001-12-01

    Peter Singer's recent appointment to Princeton University created considerable controversy, most of it focused on his proposal for active euthanasia of disabled infants. Singer articulates utilitarian ideas that often appear in public discussions of euthanasia. Drawing on Pope John Paul II's work on ethics and suffering, I argue that Singer's utilitarian theory of value is impoverished. After introducing the Pope's ethic based on the imago dei, I discuss love as self-gift. I show how this concept supports a theory of value in which spiritual goods are preeminent over material goods. I then describe how suffering reveals spiritual goods, discussing how participation in Christ's suffering can alter our perception of value. I also consider how communal responses to suffering provide opportunities for self-giving. Third, I consider Singer's proposal for killing infants with hemophilia, arguing that it arbitrarily ignores spiritual goods. I then discuss proposals to kill anencephalic infants, discussing how parental responses to their suffering can demonstrate an extraordinary love in seemingly hopeless circumstances. I conclude by calling for a more sustained social response to euthanasia initiatives.

  12. Charged lepton flavour violation searches at the Paul Scherrer Institut: Status of the MEGII and Mu3e experiments

    NASA Astrophysics Data System (ADS)

    Papa, Angela

    2018-05-01

    The MEG experiment has recently set a new upper limit on the branching ratio of the μ+ → e+γ decay, B(μ+ → e+γ) < 4.2 × 10-13 (at 90% confidence level) and un upgrade of the experiment (the MEGII experiment) is ongoing with the aim of improving the single event sensitivity (SES) by one order of magnitude with respect to the previous MEG experiment's SES. The strong scientific motivation associated with the charged Lepton Flavour Violation (cLFV) searches pushes also towards searching for the complementary muon cLFV μ+ → e+e+e- decay with the Mu3e experiment aiming at a SES improved by at least three orders of magnitude with respect to the previous SINDRUM experiment's SES (phase I) up to an ultimate SES of few ×10-16. Both experiments will be hosted at the Paul Scherrer Institut which delivers the most intense continuous low energy muon beam in the world up to few ×108 μ/s. The status of both the MEGII and Mu3e experiments is given.

  13. Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's "magic (nano)bullet" for cancer theranostics?

    PubMed

    Datta, N R; Krishnan, S; Speiser, D E; Neufeld, E; Kuster, N; Bodis, S; Hofmann, H

    2016-11-01

    Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthermia at 39-45°C is a potent radiosensitiser and has been shown to improve therapeutic outcomes in various tumours through its synergy with chemotherapy. Gene silencing approaches, using small interfering RNAs and microRNAs, are also being explored in clinical trials in oncology. The rapid developments in multifunctional nanoparticles provide ample opportunities to integrate both diagnostic and therapeutic modalities into a single effective cancer "theranostic" vector. Nanoparticles could extravasate passively into the tumour tissues in preference to the adjacent normal tissues by capitalizing on the enhanced permeability and retention effect. Tumour targeting might be further augmented by conjugating tumour-specific peptides and antibodies onto the surface of these nanoparticles or by activation through electromagnetic radiations, laser or ultrasound. Magnetic nanoparticles can induce hyperthermia in the presence of an alternating magnetic field, thereby multifunctionally with tumour-specific payloads empowering tumour specific radiotheranostics (for both imaging and radiotherapy), chemotherapy drug delivery, immunotherapy and gene silencing therapy. Such a (nano)bullet could realise the "magic bullet" conceived by Paul Ehrlich more than a century ago. This article discusses the various aspects of this "magic (nano)bullet" and the challenges that need to be addressed to usher in this new paradigm in modern cancer diagnostics and therapeutics. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Paul Wittgenstein's right arm and his phantom: the saga of a famous concert pianist and his amputation.

    PubMed

    Boller, François; Bogousslavsky, Julien

    2015-01-01

    Reports of postamputation pain and problems linked to phantom limbs have increased in recent years, particularly in relation to war-related amputations. These problems are still poorly understood and are considered rather mysterious, and they are difficult to treat. In addition, they may shed light on brain physiology and neuropsychology. Functional neuroimaging techniques now enable us to better understand their pathophysiology and to consider new rehabilitation techniques. Several artists have suffered from postamputation complications and this has influenced not only their personal life but also their artistic work. Paul Wittgenstein (1887-1961), a pianist whose right arm was amputated during the First World War, became a famous left-handed concert performer. His case provides insight into Post-World War I musical and political history. More specifically, the impact on the artistic life of this pianist illustrates various postamputation complications, such as phantom limb, stump pain, and especially moving phantom. The phantom movements of his right hand helped him develop the dexterity of his left hand. Wittgenstein played piano works that were written especially for him (the most famous being Ravel's Concerto for the Left Hand) and composed some of his own. Additionally, several famous composers had previously written for the left hand. © 2015 Elsevier B.V. All rights reserved.

  15. Summary of Synoptic Meteorological Observations (SSMO). South America and Selected Island Coastal Marine Areas, Atlantic Islands. Volume 3. Area 17 - Tierra del Fuego, Area 18 - Falkland Islands, Area 19 -South Georgia, Area 20 - Tristan da Cunha Group, Area 21 - Trindade, Area 22 - St. Helena, Area 23 - Ascension, Area 24 - St. Peter and Paul Rocks

    DTIC Science & Technology

    1977-06-01

    0 17.5 .0 .0 .0 .0 .0 .0 .0 FACE »21 »TW* ■■’■ "■ IIUI" »E«ICD! fOVE«-«LO 1963-1970 JANUARY TABLE 18 (CONTi IKEA 0021 TOINDADE...DIRECTION VIPSuS SE4 HEIGHTS IFTl IKEA 0024 ST, PETER AND PAUL ROCKS ,6N 29.3» s iu HGT 1-3 4-10 11-21 22-33 34-47 41« PCT 1...l". - L ■■■’■■’ • ’ " wwm PEIKOl iQVER-»LLI IS’OS-l1»?» I SFPTEMBfR TABLE 16 (CDNT1 IKEA 002« ST. PETER AND PAUL RCfKS

  16. Slater-Pauling behavior within quaternary intermetallic borides of the Ti{sub 3}Co{sub 5}B{sub 2} structure-type

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burghaus, Jens; Dronskowski, Richard, E-mail: drons@HAL9000.ac.rwth-aachen.d; Miller, Gordon J.

    2009-10-15

    First-principles, density-functional studies of several intermetallic borides of the general type M{sub 2}M'Ru{sub 5-n}Rh{sub n}B{sub 2} (n=0-5; M=Sc, Ti, Nb; M'=Fe, Co) show that the variation in saturation magnetic moment with valence-electron count follows a Slater-Pauling curve, with a maximum moment occurring typically at 66 valence electrons. The magnetic moments in these compounds occur primarily from the 3d electrons of the magnetically active M' sites, with some contribution from the Ru/Rh sites via magnetic polarization. Electronic DOS curves reveal that a rigid-band approach is a reasonable approximation for the estimation of saturation moments and the analysis of orbital interactions inmore » this family of complex borides. COHP analyses of the M'-M' orbital interactions indicate optimized interactions in the minority spin states for Co-containing phases, but strong bonding interactions remaining in Fe-containing phases. - Graphical abstract: Theoretically determined (spin-polarized LMTO-GGA) local magnetic moments as a function of the chemical valence Z for various intermetallic borides.« less

  17. Goethe: A bipolar personality? Periodicity of affective states in Johann Wolfgang von Goethe as reflected by Paul Julius Möbius.

    PubMed

    Steinberg, Holger; Schönknecht, Peter

    2018-01-01

    This paper aims to investigate the character and etiological basis of German poet Johann Wolfgang von Goethe's mental disorder. From 1898, German neuropsychiatrist Paul Julius Möbius developed the hypothesis that Goethe's work provided several hints for the notion that the German poet suffered from a distinct bipolar disorder. The paper investigates Möbius's psychopathographic study on Goethe and his hypothesis of a mood periodicity in Goethe against the mirror of modern concepts. Möbius came to the conclusion that Goethe's illness was bipolar in character and became visible at intervals of seven years and lasted for about two years. The majority of Möbius's contemporary psychiatric colleagues (Emil Kraepelin, Max Isserlin, Ernst Kretschmer, Josef Breuer) supported this view which has still not been convincingly challenged. In present-day terms, Möbius's hypothesis can be best mirrored as a subclinical foundation of mood disorder. Furthermore, with his extensive study, Möbius disproved the common notion that Goethe had suffered from an illness as the result of a syphilitic infection.

  18. 46 CFR Appendix A to Part 520 - Standard Terminology and Codes

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DTB Firkin FIR Flo-Bin FLO Frame FRM Flask FSK Forward Reel FWR Garment on Hanger GOH Heads of Beef... Private Vehicle POV Pipe Rack PRK Quarters of Beef QTR Rail (semiconductor) RAL Rack RCK Reel REL Roll ROL Reverse Reel RVR Sack SAK Shook SHK Sides of Beef SID Skid SKD Skid, Elev, Lift Trk SKE Sleeve SLV Spin...

  19. 46 CFR Appendix A to Part 520 - Standard Terminology and Codes

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DTB Firkin FIR Flo-Bin FLO Frame FRM Flask FSK Forward Reel FWR Garment on Hanger GOH Heads of Beef... Private Vehicle POV Pipe Rack PRK Quarters of Beef QTR Rail (semiconductor) RAL Rack RCK Reel REL Roll ROL Reverse Reel RVR Sack SAK Shook SHK Sides of Beef SID Skid SKD Skid, Elev, Lift Trk SKE Sleeve SLV Spin...

  20. 46 CFR Appendix A to Part 520 - Standard Terminology and Codes

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DTB Firkin FIR Flo-Bin FLO Frame FRM Flask FSK Forward Reel FWR Garment on Hanger GOH Heads of Beef... Private Vehicle POV Pipe Rack PRK Quarters of Beef QTR Rail (semiconductor) RAL Rack RCK Reel REL Roll ROL Reverse Reel RVR Sack SAK Shook SHK Sides of Beef SID Skid SKD Skid, Elev, Lift Trk SKE Sleeve SLV Spin...

  1. 46 CFR Appendix A to Part 520 - Standard Terminology and Codes

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... DTB Firkin FIR Flo-Bin FLO Frame FRM Flask FSK Forward Reel FWR Garment on Hanger GOH Heads of Beef... Private Vehicle POV Pipe Rack PRK Quarters of Beef QTR Rail (semiconductor) RAL Rack RCK Reel REL Roll ROL Reverse Reel RVR Sack SAK Shook SHK Sides of Beef SID Skid SKD Skid, Elev, Lift Trk SKE Sleeve SLV Spin...

  2. 46 CFR Appendix A to Part 520 - Standard Terminology and Codes

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DTB Firkin FIR Flo-Bin FLO Frame FRM Flask FSK Forward Reel FWR Garment on Hanger GOH Heads of Beef... Private Vehicle POV Pipe Rack PRK Quarters of Beef QTR Rail (semiconductor) RAL Rack RCK Reel REL Roll ROL Reverse Reel RVR Sack SAK Shook SHK Sides of Beef SID Skid SKD Skid, Elev, Lift Trk SKE Sleeve SLV Spin...

  3. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    PubMed

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  4. Modeling bird mortality associated with the M/V Citrus oil spill off St. Paul Island, Alaska

    USGS Publications Warehouse

    Flint, Paul L.; Fowler, Ada C.; Rockwell, Robert F.

    1999-01-01

    We developed a model to estimate the number of bird carcasses that were likely deposited on the beaches of St. Paul Island, Alaska following the M/V Citrus oil spill in February 1996. Most of the islands beaches were searched on an irregular schedule, resulting in the recovery of 876 King Eider carcasses. A sub-sample of beaches were intensively studied to estimate daily persistence rate and detection probability [Fowler, A.C., Flint, P.L., 1997. Marine Pollution Bulletin]. Using these data, our model predicted that an additional 733±70 King Eider carcasses were not detected during our searches. Therefore, we estimate that at least 1609±70 King Eider carcasses occurred on beaches as a result of the spill. We lacked sufficient sample size to model losses for other species, thus we applied the estimated recovery rate for King Eiders (54%) to other species and estimate a total combined loss of 1765 birds. In addition, 165 birds were captured alive making the total estimated number of birds impacted by the M/V Citrus spill 1930. Given that oiled birds occurred in places on the island which could not be systematically searched combined with the fact that it was unlikely that oiled birds that died at sea would have been recovered during our searches [Flint, P.L., Fowler, A.C., 1998. Marine Pollution Bulletin], our estimate of total mortality associated with the spill should be considered a minimum.

  5. Perfluorinated compound concentrations in great blue heron eggs near St. Paul, Minnesota, USA, in 1993 and 2010-2011

    USGS Publications Warehouse

    Custer, Thomas W.; Dummer, Paul M.; Custer, Christine M.; Wu, Qian; Kannan, Kurunthachalam; Trowbridge, Annette

    2013-01-01

    A great blue heron (Ardea herodias) colony on Pig's Eye Island on the Mississippi River near St. Paul, Minnesota, USA, is located near several potential perfluorinated compound (PFC) sources. The PFC concentrations in great blue heron eggs reported from a 1993 collection from the Pig's Eye colony were among the highest measured in bird eggs worldwide. The objective of this investigation was to determine whether PFC concentrations in great blue heron eggs at the Pig's Eye colony have changed since 1993. Total PFC concentrations in great blue heron eggs collected at the Pig's Eye colony in 2010 and 2011 (geometric mean = 340 and 492 ng/g wet wt) were 60% lower than the 1993 collection (1,015 ng/g wet wt). Among PFCs, perfluoroalkyl sulfonate concentrations were lower and perfluoroalkyl carboxylate concentrations were higher in the 2010 and 2011 collections. Two of 20 (10%) of the eggs analyzed from Pig's Eye in 2010 and 2011 were >1,000 ng PFCs/g wet weight and the maximum PFC value (2,506 ng PFCs/g wet wt) measured in 2010 and 2011 was among the highest PFC concentration reported in bird eggs. These high concentrations are at levels associated with physiological and neurological effects in birds.

  6. Paired Insulators and High-Temperature Superconductors

    NASA Astrophysics Data System (ADS)

    Geballe, T. H.; Kivelson, S. A.

    In common with all condensed matter physicists of our generations, our way of thinking about our field was shaped and greatly inspired by countless seminal works of Phil Anderson -- a debt we are pleased to have the opportunity to acknowledge. Discussing plans for this article, we spent many pleasant times debating which particular contribution to highlight -- super-exchange (THG), Anderson-Higgs (SAK), the Anderson--Morel pseudopotential (THG), poor man's scaling (SAK), etc. In the end, we opted to highlight a single specific paper which greatly affected each of us at the time, and which has continued to exert a strong intellectual influence on us in the ensuing years. Almost 40 years ago in Ref. 1, Phil introduced the negative U center to account for the fact that most glasses and amorphous semiconductors are diamagnetic. This paper has been highly influential, but certainly does not rank among Phil's most famous works; however, focusing on it enables us to re-acquaint a younger generation with another of Phil's contributions, and to use this as a springboard to discuss some forward-looking extensions that continue to fascinate us...

  7. Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae.

    PubMed

    Elbing, Karin; McCartney, Rhonda R; Schmidt, Martin C

    2006-02-01

    Members of the Snf1/AMPK family of protein kinases are activated by distinct upstream kinases that phosphorylate a conserved threonine residue in the Snf1/AMPK activation loop. Recently, the identities of the Snf1- and AMPK-activating kinases have been determined. Here we describe the purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. The identities of proteins associated with the Snf1-activating kinases were determined by peptide mass fingerprinting. These kinases, Sak1, Tos3 and Elm2 do not appear to require the presence of additional subunits for activity. Sak1 and Snf1 co-purify and co-elute in size exclusion chromatography, demonstrating that these two proteins form a stable complex. The Snf1-activating kinases phosphorylate the activation loop threonine of Snf1 in vitro with great specificity and are able to do so in the absence of beta and gamma subunits of the Snf1 heterotrimer. Finally, we showed that the Snf1 kinase domain isolated from bacteria as a GST fusion protein can be activated in vitro and shows substrate specificity in the absence of its beta and gamma subunits.

  8. Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae

    PubMed Central

    2005-01-01

    Members of the Snf1/AMPK family of protein kinases are activated by distinct upstream kinases that phosphorylate a conserved threonine residue in the Snf1/AMPK activation loop. Recently, the identities of the Snf1- and AMPK-activating kinases have been determined. Here we describe the purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. The identities of proteins associated with the Snf1-activating kinases were determined by peptide mass fingerprinting. These kinases, Sak1, Tos3 and Elm2 do not appear to require the presence of additional subunits for activity. Sak1 and Snf1 co-purify and co-elute in size exclusion chromatography, demonstrating that these two proteins form a stable complex. The Snf1-activating kinases phosphorylate the activation loop threonine of Snf1 in vitro with great specificity and are able to do so in the absence of β and γ subunits of the Snf1 heterotrimer. Finally, we showed that the Snf1 kinase domain isolated from bacteria as a GST fusion protein can be activated in vitro and shows substrate specificity in the absence of its β and γ subunits. PMID:16201971

  9. Characterization of oil and gas reservoir heterogeneity; Final report, November 1, 1989--June 30, 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sharma, G.D.

    1993-09-01

    The Alaskan North Slope comprises one of the Nation`s and the world`s most prolific oil province. Original oil in place (OOIP) is estimated at nearly 70 BBL (Kamath and Sharma, 1986). Generalized reservoir descriptions have been completed by the University of Alaska`s Petroleum Development Laboratory over North Slope`s major fields. These fields include West Sak (20 BBL OOIP), Ugnu (15 BBL OOIP), Prudhoe Bay (23 BBL OOIP), Kuparuk (5.5 BBL OOIP), Milne Point (3 BBL OOIP), and Endicott (1 BBL OOIP). Reservoir description has included the acquisition of open hole log data from the Alaska Oil and Gas Conservation Commissionmore » (AOGCC), computerized well log analysis using state-of-the-art computers, and integration of geologic and logging data. The studies pertaining to fluid characterization described in this report include: experimental study of asphaltene precipitation for enriched gases, CO{sup 2} and West Sak crude system, modeling of asphaltene equilibria including homogeneous as well as polydispersed thermodynamic models, effect of asphaltene deposition on rock-fluid properties, fluid properties of some Alaskan north slope reservoirs. Finally, the last chapter summarizes the reservoir heterogeneity classification system for TORIS and TORIS database.« less

  10. Phantoms in artists: the lost limbs of Blaise Cendrars,Arthur Rimbaud, and Paul Wittgenstein.

    PubMed

    Tatu, Laurent; Bogousslavsky, Julien; Boller, François

    2014-01-01

    There have been an increasing number of reports of postamputation pain and problems linked to phantom limbs over recent years, particularly in relation to war-related amputations. These problems, which are often poorly understood and considered rather mysterious, are still relevant because they are difficult to treat medically. Functional neuroimaging techniques now enable us to better understand their pathophysiology and to consider new rehabilitation techniques. Phantom limbs have often been a source of inspiration to writers, particularly in the period following the First World War, which was responsible for thousands of amputees. Some artists have suffered from postamputation complications themselves and have expressed them through their artistic works. Blaise Cendrars (1887-1961), one of the greatest authors of the twentieth century, suffered from stump pain and phantom limb phenomena for almost half a century following the amputation of his right arm during the First World War. He suffered from these phenomena until the end of his life and his literary work and personal correspondence are peppered with references to them. Arthur Rimbaud (1854-1891), one of the most famous poets in world literature, developed severe stump pain after his right leg was amputated due to a tumor. He survived for only six months after the procedure but left behind an account of the pain he experienced in correspondence to his family. The famous pianist Paul Wittgenstein (1887-1961), whose right arm was amputated during the First World War, became a famous left-handed concert pianist. The phantom movements of his right hand helped him to develop the dexterity of his left hand. The impact on the artistic life of these three men provides an original illustration of the various postamputation complications, specifically phantom limbs, stump pain, and moving phantom.

  11. Peasant struggles and social change: migration, households and gender in a rural Turkish society.

    PubMed

    Ilcan, S M

    1994-01-01

    "This article sheds light on the interrelationship of seasonal migration, subsistence production and peasant relations in a community (Sakli) located in Turkey's northwestern countryside.... While migrant labor is understood by local villagers as forming part of a continual battle to preserve local tradition and kinship ties, this article shows how it reduces the dominion of landlords while creating internal household differentiation and gendered hierarchies." excerpt

  12. The pathway by which the yeast protein kinase Snf1p controls acquisition of sodium tolerance is different from that mediating glucose regulation.

    PubMed

    Ye, Tian; Elbing, Karin; Hohmann, Stefan

    2008-09-01

    It recently became apparent that the highly conserved Snf1p protein kinase plays roles in controlling different cellular processes in the yeast Saccharomyces cerevisiae, in addition to its well-known function in glucose repression/derepression. We have previously reported that Snf1p together with Gis4p controls ion homeostasis by regulating expression of ENA1, which encodes the Ena1p Na(+) extrusion system. In this study we found that Snf1p is rapidly phosphorylated when cells are exposed to NaCl and this phosphorylation is required for the role of Snf1p in Na(+) tolerance. In contrast to activation by low glucose levels, the salt-induced phosphorylation of Snf1p promoted neither phosphorylation nor nuclear export of the Mig1p repressor. The mechanism that prevents Mig1p phosphorylation by active Snf1p under salt stress does not involve either hexokinase PII or the Gis4p regulator. Instead, Snf1p may mediate upregulation of ENA1 expression via the repressor Nrg1p. Activation of Snf1p in response to glucose depletion requires any of the three upstream protein kinases Sak1p, Tos3p and Elm1p, with Sak1p playing the most prominent role. The same upstream kinases were required for salt-induced Snf1p phosphorylation, and also under these conditions Sak1p played the most prominent role. Unexpectedly, however, it appears that Elm1p plays a dual role in acquisition of salt tolerance by activating Snf1p and in a presently unknown parallel pathway. Together, these results indicate that under salt stress Snf1p takes part in a different pathway from that during glucose depletion and this role is performed together as well as in parallel with its upstream kinase Elm1p. Snf1p appears to be part of a wider functional network than previously anticipated and the full complexity of this network remains to be elucidated.

  13. [The Innovation Office of the Paul-Ehrlich-Institut. Regulatory support during the scientific development of ATMP].

    PubMed

    Ziegele, B; Dahl, L; Müller, A T

    2011-07-01

    In conformity with Regulation (EC) No. 1394/2007, advanced therapy medicinal products (ATMP) are now subject to the centralized marketing authorization procedure. This also applies to most medicinal products in regenerative medicine. ATMP that have been marketed in a member state by the end of 2008 must be centrally authorized by the end of 2012 at the latest. In exceptional cases, a national authorization is acceptable. Developers of these medicinal products are usually academic institutions or small- and medium-sized enterprises (SME). They focus on scientific aspects and usually have little experience with pharmaceutical law. The Innovation Office of the Paul-Ehrlich-Institut (PEI) is designed to support developers of medicinal products in the areas between research and development, on the one hand, and regulatory requirements, on the other. Its main role is supportive advice in the regulatory field with an emphasis on ATMP. For this purpose, the Innovation Office makes use of core competences from various experts at the PEI in order to provide a quality consulting service to those companies who are seeking advice as early as possible and hand in hand with the development process. The aim is to support the developer to identify the appropriate regulatory pathway and to provide advice for each individual medicinal product at its corresponding stage of development in order to develop a high-quality ATMP manufactured on the basis of positive nonclinical results and appropriate clinical studies that meet all the necessary requirements for the application of a marketing authorization.

  14. Prospecting Anticancer Compounds in Actinomycetes Recovered from the Sediments of Saint Peter and Saint Paul's Archipelago, Brazil.

    PubMed

    Ferreira, Elthon G; Torres, Maria da Conceição M; da Silva, Alison B; Colares, Larissa L F; Pires, Karine; Lotufo, Tito M C; Silveira, Edilberto R; Pessoa, Otília D L; Costa-Lotufo, Leticia V; Jimenez, Paula C

    2016-09-01

    Saint Peter and Saint Paul's Archipelago is a collection of 15 islets and rocks remotely located in the equatorial Atlantic Ocean. In this particular site, the present project intended to assess the biodiversity and biotechnological potential of bacteria from the actinomycete group. This study presents the first results of this assessment. From 21 sediment samples, 268 strains were isolated and codified as BRA followed by three numbers. Of those, 94 strains were grown in liquid media and submitted to chemical extractions with AcOEt (A), BuOH (B), and MeOH (M). A total of 224 extracts were screened for their cytotoxic activity and 41 were significantly active against HCT-116 cancer cells. The obtained IC 50 values ranged from 0.04 to 31.55 μg/ml. The HR-LC/MS dereplication analysis of the active extracts showed the occurrence of several known anticancer compounds. Individual compounds, identified using HR-MS combined with analysis of the AntiMarin database, included saliniketals A and B, piericidins A and C and glucopiericidin A, staurosporine, N-methylstaurosporine, hydroxydimethyl-staurosporine and N-carbamoylstaurosporine, salinisporamycin A, and rifamycins S and B. BRA-199, identified as Streptomyces sp., was submitted to bioassay-guided fractionation, leading to isolation of the bioactive piericidins A and C, glucopiericidin, and three known diketopiperazines, cyclo(l-Phe-trans-4-OH-l-Pro), cyclo(l-Phe-l-Pro), and cyclo(l-Trp-l-Pro). © 2016 Wiley-VHCA AG, Zürich.

  15. A scale of metal ion binding strengths correlating with ionic charge, Pauling electronegativity, toxicity, and other physiological effects.

    PubMed

    Kinraide, Thomas B; Yermiyahu, Uri

    2007-09-01

    Equilibrium constants for binding to plant plasma membranes have been reported for several metal ions, based upon adsorption studies and zeta-potential measurements. LogK values for the ions are these: Al(3+), 4.30; La(3+), 3.34; Cu(2+), 2.60; Ca(2+) and Mg(2+), 1.48; Na(+) and K(+), 0 M(-1). These values correlate well with logK values for ion binding to many organic and inorganic ligands. LogK values for metal ion binding to 12 ligands were normalized and averaged to produce a scale for the binding of 49 ions. The scale correlates well with the values presented above (R(2)=0.998) and with ion binding to cell walls and other biomass. The scale is closely related to the charge (Z) and Pauling electronegativity (PE) of 48 ions (all but Hg(2+)); R(2)=0.969 for the equation (Scale values)=-1.68+Z(1.22+0.444PE). Minimum rhizotoxicity of metal ions appears to be determined by binding strengths: log a(PM,M)=1.60-2.41exp[0.238(Scale values)] determines the value of ion activities at the plasma membrane surface (a(PM,M)) that will ensure inhibition of root elongation. Additional toxicity appears to be related to softness, accounting for the great toxicity of Ag(+), for example. These binding-strength values correlate with additional physiological effects and are suitable for the computation of cell-surface electrical potentials.

  16. Akamai Internship Program

    DTIC Science & Technology

    2015-04-17

    AFRL-OSR-VA-TR-2015-0094 AKAMAI INTERNSHIP PROGRAM Lisa Hunter UNIVERSITY OF HAWAII SYSTEMS Final Report 04/17/2015 DISTRIBUTION A: Distribution...NUMBER n/a 5f. WORK UNIT NUMBER n/a 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of Hawaii Systems 2530 Dole St. SAK D-200...Honolulu, HI 96822-2309 8. PERFORMING ORGANIZATION REPORT NUMBER n/a 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) University of

  17. [Narratives in the study of mental health care practices: contributions of the perspectives of Paul Ricoeur, Walter Benjamin and of medical anthropology].

    PubMed

    Onocko-Campos, Rosana Teresa; Palombini, Analice de Lima; Leal, Erotildes; de Serpa, Octavio Domont; Baccari, Ivana Oliveira Preto; Ferrer, Ana Luiza; Diaz, Alberto Giovanello; Xavier, Maria Angélica Zamora

    2013-10-01

    Narratives are ever more frequent in qualitative studies seeking to interpret experiences and the different viewpoints of individuals in a given context. Starting from this concept, the tradition that addresses narrative is reexamined, including the philosophy of Paul Ricoeur, the historical perspective of Walter Benjamin and the field of medical anthropology grounded in phenomenology. In Ricoeur, with hermeneutics as a variation derived from phenomenology, narrative is linked to temporality. In Benjamin, narrative comprised of bits and pieces, always inconclusive, emerges in spite of the official stories. If Ricoeur retrieves tradition from Gadamer as a fundamental component for the construction of the world of a text that makes imitation of life possible, Benjamin, faced with the collapse of tradition, suggests the invention of narrative forms outside the traditional canons, making it possible to hark to the past in order to change the present. Assumptions of medical anthropology are also presented, as they consider narrative a dimension of life and not its abstraction, namely an embodied and situated narrative. Lastly, three distinct research projects in mental health that use narrative linked to the theoretical concepts cited with their differences and similarities are presented.

  18. Geophysical evidence for the intersection of the St Paul, Cape Palmas and Grand Cess fracture zones with the continental margin of Liberia, West Africa

    USGS Publications Warehouse

    Behrendt, John C.; Schlee, J.; Robb, James M.

    1974-01-01

    PUBLISHED reconstructions of Gondwana continent1 (Fig. la) show a gap in fit near the junction of the Americas and Africa. To study this critical area, the Unitedgeo I made geophysical measurements and collected rock samples across the continental margin of Liberia (USGS-IDOE cruise leg 5) in November 1971. Figure Ib indicates the location of the 5,400 km of ship track on a generalised bathymetric map2. We shall discuss the data in detail elsewhere. Here we present the evidence for the existence of three fracture zones, two of which have not been reported previously, intersecting the continental margin at the north end of the South Atlantic, which remained closed probably until Cretaceous time. We suggest that Precambrian structures on the African continent controlled the location of these fracture zones. Figure Ic compares gravity and magnetic profiles and interpretations of the seismic profiles for three selected lines (27, 30 and 34) crossing the Grand Cess, Cape Palmas and St Paul fracture zones, respectively. ?? 1974 Nature Publishing Group.

  19. Continuity and change in subsistence harvests in five Bering Sea communities: Akutan, Emmonak, Savoonga, St. Paul, and Togiak

    NASA Astrophysics Data System (ADS)

    Fall, James A.; Braem, Nicole S.; Brown, Caroline L.; Hutchinson-Scarbrough, Lisa B.; Koster, David S.; Krieg, Theodore M.

    2013-10-01

    To document and quantify subsistence harvests of fish and wildlife resources, and provide topics for subsequent key respondent interviews to collect local and traditional knowledge (LTK) about the Bering Sea ecosystem, comprehensive household harvest surveys were conducted in four Bering Sea Alaska Native communities: Akutan, Emmonak, Savoonga, and Togiak. In a fifth community, St. Paul, annual programs to document two key subsistence resources, fur seals and sea lions, continued. Surveys documented relatively high and diverse subsistence harvests, consistent with earlier research that demonstrated the continuing economic, social, and cultural importance of subsistence uses of wild resources. The research also found differences in subsistence use patterns compared to previous years' studies, such as harvest levels, harvest composition, and diversity of resources used, although differences between study years were not uniform across communities. Survey respondents, as well as key respondents in subsequent interviews, identified a complex range of personal, economic, and environmental factors when comparing subsistence uses in the study year with other years, such as increasing costs of fuel and purchased food, commercial fisheries harvests and bycatch, more persistent storms and less predictable winds, and reduced sea ice. Such conditions affect resource abundance and locations as well as access to fish and wildlife populations, and may shape long-term trends. So far, as in the past, families and communities have adapted to changing economic, social, and environmental conditions, but the future is less clear if such changes intensify or accelerate. Local community residents should be essential partners in future efforts to understand these complex processes that affect the natural resources of the Bering Sea.

  20. Receptors and aging: dedicated to the memory of Paul Ehrlich for the 100th anniversary of his Nobel Prize.

    PubMed

    Robert, L; Labat-Robert, J; Robert, A M

    2010-01-01

    The initiation and evolution of the receptor concept and its application in pharmacology can be traced back to Paul Ehrlich's original experiments. Since several decades the receptor concept is in the foreground of cell biology and pharmacology. We present here a short reminder of Ehrlich's concepts on receptor action, its evolution and modifications as a result of increasing life expectancy of human societies. Results obtained by several teams on the age-dependent modifications of receptor function are reviewed with special emphasis on the age-dependent loss of receptors and of uncoupling of receptors from their intracellular transmission pathway. As a special example we summarize our results on the elastin receptor and its age-dependent modifications. These modifications result in the loss of the physiologically helpful functions mediated by this receptor, such as vasodilation by coupling with the inducible nitric oxide synthase (iNOS)-inhibition of cellular cholesterol synthesis and modulation of free radical production by inhibition of the guanine nucleotide binding protein (Gi protein)-mediated transmission pathway. Only the harmful effects such as free radical release and up-regulation of elastase production remain in "old" cells. The age-dependent modifications of receptor function play an important role in the increasing frequency and severity of age-related diseases such as athero-arteriosclerosis and emphysema as well as the loss of hormone- and drug actions. These processes and their inhibition or correction represent a new challenge for cellular pharmacology. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

  1. Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection

    PubMed Central

    Burlak, Christopher; Hammer, Carl H; Robinson, Mary-Ann; Whitney, Adeline R; McGavin, Martin J; Kreiswirth, Barry N; DeLeo, Frank R

    2007-01-01

    Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a threat to human health worldwide. Although progress has been made, mechanisms of CA-MRSA pathogenesis are poorly understood and a comprehensive analysis of CA-MRSA exoproteins has not been conducted. To address that deficiency, we used proteomics to identify exoproteins made by MW2 (USA400) and LAC (USA300) during growth in vitro. Two hundred and fifty unique exoproteins were identified by 2-dimensional gel electrophoresis coupled with automated direct infusion-tandem mass spectrometry (ADI-MS/MS) analysis. Eleven known virulence-related exoproteins differed in abundance between the strains, including alpha-haemolysin (Hla), collagen adhesin (Cna), staphylokinase (Sak), coagulase (Coa), lipase (Lip), enterotoxin C3 (Sec3), enterotoxin Q (Seq), V8 protease (SspA) and cysteine protease (SspB). Mice infected with MW2 or LAC produced antibodies specific for known or putative virulence factors, such as autolysin (Atl), Cna, Ear, ferritin (Ftn), Lip, 1-phosphatidylinositol phosphodiesterase (Plc), Sak, Sec3 and SspB, indicating the exoproteins are made during infection in vivo. We used confocal microscopy to demonstrate aureolysin (Aur), Hla, SspA and SspB are produced following phagocytosis by human neutrophils, thereby linking exoprotein production in vitro with that during host–pathogen interaction. We conclude that the exoproteins identified herein likely account in part for the success of CA-MRSA as a human pathogen. PMID:17217429

  2. Ciprofloxacin and Trimethoprim Cause Phage Induction and Virulence Modulation in Staphylococcus aureus

    PubMed Central

    Goerke, Christiane; Köller, Johanna; Wolz, Christiane

    2006-01-01

    In Staphylococcus aureus strains of human origin, phages which integrate into the chromosomal gene coding for β-hemolysin (hlb) are widely distributed. Most of them encode accessory virulence determinants such as staphylokinase (sak) or enterotoxins. Here, we analyzed the effects of ciprofloxacin and trimethoprim on phage induction and expression of phage-encoded virulence factors by using isolates from patients with cystic fibrosis for which the induction of hlb-converting phages was demonstrated in vivo (C. Goerke, S. Matias y Papenberg, S. Dasbach, K. Dietz, R. Ziebach, B. C. Kahl, and C. Wolz, J. Infect. Dis. 189:724-734, 2004) as well as a φ13 lysogen of phage-cured strain 8325-4. Treatment of lysogens with subinhibitory concentrations of either antibiotic resulted in (i) delysogenization of strains resembling the isolates picked up after chronic lung infection and (ii) replication of phages in the bacterial host in a dose-dependent manner. Ciprofloxacin treatment resulted in enhanced recA transcription, indicating involvement of the SOS response in phage mobilization. Induction of φ13 was linked to elevated expression of the phage-encoded virulence gene sak, chiefly due to the activation of latent phage promoters. In summary, we could show the induction of hlb-converting phages and a subsequent virulence modulation of the host bacterium by ciprofloxacin and trimethoprim. PMID:16377683

  3. 76 FR 37194 - Surety Companies Acceptable on Federal Bonds; Change in State of Incorportation, Business Address...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... State of Incorportation, Business Address and Phone; St. Paul Fire and Marine Insurance Company; St. Paul Guardian Insurance Company; St. Paul Mercury Insurance Company AGENCY: Financial Management... that St. Paul Fire and Marine Insurance Company (24767), St. Paul Guardian Insurance Company (24775...

  4. Spot-scanning proton therapy for malignant soft tissue tumors in childhood: First experiences at the Paul Scherrer Institute

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Timmermann, Beate; Schuck, Andreas; Niggli, Felix

    2007-02-01

    Purpose: Radiotherapy plays a major role in the treatment strategy of childhood sarcomas. Consequences of treatment are likely to affect the survivor's quality of life significantly. We investigated the feasibility of spot-scanning proton therapy (PT) for soft tissue tumors in childhood. Methods and Materials: Sixteen children with soft tissue sarcomas were included. Median age at PT was 3.3 years. In 10 children the tumor histology was embryonal rhabdomyosarcoma. All tumors were located in the head or neck, parameningeal, or paraspinal, or pelvic region. In the majority of children, the tumor was initially unresectable (Intergroup Rhabdomyosarcoma Study [IRS] Group III inmore » 75%). In 50% of children the tumors exceeded 5 cm. Fourteen children had chemotherapy before and during PT. Median total dose of radiotherapy was 50 cobalt Gray equivalent (CGE). All 16 children were treated with spot-scanning proton therapy at the Paul Scherrer Institute, and in 3 children the PT was intensity-modulated (IMPT). Results: After median follow-up of 1.5 years, local control was achieved in 12 children. Four children failed locally, 1 at the border of the radiation field and 3 within the field. All 4 children died of tumor recurrence. All 4 showed unfavorable characteristic either of site or histopathology of the tumor. Acute toxicity was low, with Grade 3 or 4 side effects according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria occurring in the bone marrow only. Conclusions: Proton therapy was feasible and well tolerated. Early local control rates are comparable to those being achieved after conventional radiotherapy. For investigations on late effect, longer follow-up is needed.« less

  5. Spot-Scanning Proton Radiation Therapy for Pediatric Chordoma and Chondrosarcoma: Clinical Outcome of 26 Patients Treated at Paul Scherrer Institute

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rombi, Barbara; ATreP; Ares, Carmen, E-mail: carmen.ares@psi.ch

    Purpose: To evaluate the clinical results of fractionated spot-scanning proton radiation therapy (PT) in 26 pediatric patients treated at Paul Scherrer Institute for chordoma (CH) or chondrosarcoma (CS) of the skull base or axial skeleton. Methods and Materials: Between June 2000 and June 2010, 19 CH and 7 CS patients with tumors originating from the skull base (17) and the axial skeleton (9) were treated with PT. Mean age at the time of PT was 13.2 years. The mean prescribed dose was 74 Gy (relative biological effectiveness [RBE]) for CH and 66 Gy (RBE) for CS, at a dose ofmore » 1.8-2.0 Gy (RBE) per fraction. Results: Mean follow-up was 46 months. Actuarial 5-year local control (LC) rates were 81% for CH and 80% for CS. Actuarial 5-year overall survival (OS) was 89% for CH and 75% for CS. Two CH patients had local failures: one is alive with evidence of disease, while the other patient succumbed to local recurrence in the surgical pathway. One CS patient died of local progression of the disease. No high-grade late toxicities were observed. Conclusions: Spot-scanning PT for pediatric CH and CS patients resulted in excellent clinical outcomes with acceptable rates of late toxicity. Longer follow-up time and larger cohort are needed to fully assess tumor control and late effects of treatment.« less

  6. Planning and Problem Solving

    DTIC Science & Technology

    1982-10-01

    Artificial Intelig ~ence (Vol. III, edited by Paul R. Cohen and’ Edward A.. Feigenbaum)’, The chapter was written B’ Paul Cohen, with contributions... Artificial Intelligence (Vol. III, edited by Paul R. Cohen and EdWard A. Feigenbaum). The chapter was written by Paul R. Cohen, with contributions by Stephen...Wheevoats"EntermdI’ Planning and Problem ’Solving by Paul R. Cohen Chaptb-rXV-of Volumec III’of the Handbook of Artificial Intelligence edited by Paul R

  7. Historic importance of some aspects of research by O. Wilford Olsen on hookworms (Uncinaria lucasi) in northern fur seals (Callorhinus ursinus) and Steller sea lions (Eumatopias jubatus) in 1951 on St. Paul Island, Alaska.

    PubMed

    Lyons, E T

    2005-03-01

    The purpose of this paper is to disseminate, more widely, certain historically important aspects of research by O. Wilford Olsen on hookworms (Uncinaria lucasi) in northern fur seals (Callorhinus ursinus) and Steller sea lions (Eumatopias jubatus) in 1951 on St. Paul Island, Alaska. Highly meaningful facets of the research were recorded only in a report with limited availability by Olsen in 1952. Portions of his research presented here include measurements of hookworm free-living infective third-stage larvae (L3) and adults, photographs of bursae, and the conclusion that the species of hookworms (U. lucasi) is probably the same in both pinniped hosts. This information is especially important because very little has been published on taxonomy of hookworms in E. jubatus.

  8. Intrinsic anharmonic effects on the phonon frequencies and effective spin-spin interactions in a quantum simulator made from trapped ions in a linear Paul trap

    NASA Astrophysics Data System (ADS)

    McAneny, M.; Freericks, J. K.

    2014-11-01

    The Coulomb repulsion between ions in a linear Paul trap gives rise to anharmonic terms in the potential energy when expanded about the equilibrium positions. We examine the effect of these anharmonic terms on the accuracy of a quantum simulator made from trapped ions. To be concrete, we consider a linear chain of Yb171+ ions stabilized close to the zigzag transition. We find that for typical experimental temperatures, frequencies change by no more than a factor of 0.01 % due to the anharmonic couplings. Furthermore, shifts in the effective spin-spin interactions (driven by a spin-dependent optical dipole force) are also, in general, less than 0.01 % for detunings to the blue of the transverse center-of-mass frequency. However, detuning the spin interactions near other frequencies can lead to non-negligible anharmonic contributions to the effective spin-spin interactions. We also examine an odd behavior exhibited by the harmonic spin-spin interactions for a range of intermediate detunings, where nearest-neighbor spins with a larger spatial separation on the ion chain interact more strongly than nearest neighbors with a smaller spatial separation.

  9. Studies of emittance growth and halo particle production in intense charged particle beams using the Paul Trap Simulator Experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gilson, Erik P.; Davidson, Ronald C.; Dorf, Mikhail

    2010-05-15

    The Paul Trap Simulator Experiment (PTSX) is a compact laboratory experiment that places the physicist in the frame-of-reference of a long, charged-particle bunch coasting through a kilometers-long magnetic alternating-gradient (AG) transport system. The transverse dynamics of particles in both systems are described by the same set of equations, including nonlinear space-charge effects. The time-dependent voltages applied to the PTSX quadrupole electrodes in the laboratory frame are equivalent to the spatially periodic magnetic fields applied in the AG system. The transverse emittance of the charge bunch, which is a measure of the area in the transverse phase space that the beammore » distribution occupies, is an important metric of beam quality. Maintaining low emittance is an important goal when defining AG system tolerances and when designing AG systems to perform beam manipulations such as transverse beam compression. Results are reviewed from experiments in which white noise and colored noise of various amplitudes and durations have been applied to the PTSX electrodes. This noise is observed to drive continuous emittance growth and increase in root-mean-square beam radius over hundreds of lattice periods. Additional results are reviewed from experiments that determine the conditions necessary to adiabatically reduce the charge bunch's transverse size and simultaneously maintain high beam quality. During adiabatic transitions, there is no change in the transverse emittance. The transverse compression can be achieved either by a gradual change in the PTSX voltage waveform amplitude or frequency. Results are presented from experiments in which low emittance is achieved by using focusing-off-defocusing-off waveforms.« less

  10. [Knowledge of German neurologists on migraine around 1890. Paul Julius Möbius and his 1894 monograph Die Migräne].

    PubMed

    Schobeß, C; Steinberg, H

    2013-08-01

    Paul Julius Möbius (1853-1907), a Leipzig-based author and editor on a vast majority of subjects, has often been acknowledged as a leading 19th-century German neurologist. His impact on the development of knowledge on migraine has likewise been pointed to. This study compares the monograph published by Möbius on the illness in 1894 with contemporary publications and with present day best practice to establish if the author really made an essential contribution to the problem of migraine. As a representative of the central theory Möbius assumed that migraine was caused by aberrations in the brain. At the same time he made it clear that due to very limited diagnostic options this was only a hypothesis. Apart from a genetic factor and these cerebral changes, for Möbius the general state of health was a decisive factor and prevention and change in lifestyle therefore played a crucial role in his therapeutic recommendations. Basically there were only few differences between the views of Möbius and his colleagues, the major dissimilarity being that Möbius postulated a merely suggestive impact but no physical effect of electrotherapy. Although Möbius's monograph on migraine lacks originality, it provides a concise, easy to understand and stylistically impressive overview on the state of knowledge at that time. Therefore, the book can be considered as a benchmark publication of German speaking neurology around 1890 on migraine and it is highly recommended to present day headache and migraine researchers as well as historians of psychiatry and neurology.

  11. CO2 exchange following peat extraction - a comparison of two paired restored/unrestored peatlands

    NASA Astrophysics Data System (ADS)

    Strachan, Ian; Strack, Maria; Pelletier, Luc; Nugent, Kelly; Rankin, Tracy

    2016-04-01

    Peat extraction is an important industry in parts of Canada and elsewhere globally. The resulting disturbance from drainage and vacuum-harvesting is mitigated through best practices which now incorporate restoration intended to return the peatland's biodiversity and greenhouse gas (GHG) exchange to that resembling the pre-disturbance state. We examine the net ecosystem exchange of CO2 (NEE) in two sets of paired peatlands. Within each pair, the extraction year was the same and the sites were treated identically post-extraction in terms of management (blocking drains or leveling as applicable). The first pair is located in the vicinity of Rivière-du-Loup, Québec, Canada and were harvested in 1980. The Bois-des-Bel (BDB) site was restored in 1999 following the methods of Quinty and Rochefort (2003). GHG fluxes have been studied at various points since restoration (e.g. Strack and Zuback, 2013) largely using chamber measurements. The site now hosts a thriving bog ecosystem with Sphagnum, Eriophorum and shrub communities. A site 30 km away near Saint-Alexandre de Kamouraska (SAK) was managed post-harvest as BDB with drains blocked but was left unrestored and now has only sparse Eriophorum with invasive species. The second pair of peatlands represents a newly extracted site near Seba Beach, Alberta, Canada. One field was restored (SBR) in autumn 2012 as per the Québec sites but with ditches infilled when the fields were levelled while the other (SBU) was left unrestored. In the summer of 2013, eddy covariance towers were installed at each location and measured NEE continuously at 10Hz throughout the subsequent periods. BDB and SBR remain operational today while SBU was removed in fall 2014 and SAK in fall 2015. In this presentation, we will focus on the coincident years of operation. After 15 years, BDB has measured NEE in the range of that observed at natural peatlands. A summer sink and winter release lead to annual uptake of CO2. At SAK, the lack of establishment

  12. Nest survival of piping plovers at a dynamic reservoir indicates an ecological trap for a threatened population

    USGS Publications Warehouse

    Anteau, Michael J.; Shaffer, Terry L.; Sherfy, Mark H.; Sovada, Marsha A.; Stucker, Jennifer H.; Wiltermuth, Mark T.

    2012-01-01

    In the past 60 years, reservoirs have reshaped riverine ecosystems and transformed breeding habitats used by the threatened piping plover (Charadrius melodus; hereafter plover). Currently, 29% of the Northern Great Plains plover population nests at reservoirs that might function as ecological traps because reservoirs have more diverse habitat features and greater dynamics in water levels than habitats historically used by breeding plovers. We examined factors influencing daily survival rates (DSR) of 346 plover nests at Lake Sakakawea (SAK; reservoir) during 2006–2009 by evaluating multiple a priori models, and we used our best model to hindcast nest success of plovers during 1985–2009. Our observed and hindcast estimates of nest success were low compared to published estimates. Previous findings indicate that plovers prefer nest sites that are low relative to water level. We found that elevation of nests above the water level had a strong positive correlation with DSR because water levels of SAK typically increased throughout the nesting period. Habitat characteristics on the reservoir differ from those that shaped nest-site selection for plovers. Accordingly, extraordinary nest loss occurs there in many years, largely due to inundation of nests, and based on low fledging rates those losses were not compensated by potential changes in chick survival. Therefore, our example supports the concept of ecological traps in birds because it addresses quantitative assessments of habitat preference and productivity over 25 years (since species listing) and affects a large portion of the population.

  13. 76 FR 43958 - Safety Zone; Rotary Club of Fort Lauderdale New River Raft Race, New River, Fort Lauderdale, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... have questions on this proposed rule, call or e-mail Lieutenant Paul A. Steiner, Sector Miami Prevention Department, Coast Guard; telephone 305-535-8724, e-mail Paul.A.Steiner@uscg.mil . If you have... Paul A. Steiner, Sector Miami Prevention Department, Coast Guard; telephone 305-535-8724, e-mail Paul.A...

  14. Paroxysmal nocturnal hemoglobinuria first described in 1882 by Paul Strübing: an example of cooperation between clinical and basic research.

    PubMed

    Wilmanns, J C

    1982-12-01

    The 100th anniversary of the first description of paroxysmal nocturnal hemoglobinuria by Paul Strübing presents an opportunity to analyze the premises valid for the description of this disease in addition to an attempt at an extensive pathophysiological analysis. Strübing's two papers of 1882 were way ahead of his time, when pathophysiology was just at its beginning, particularly considering the fact that neither Marchiafava, who is still commonly credited wit the first description of this disease (1911) and its recognition as a clinical entity (1928), nor his student Micheli analyzed the PNH syndrome in pathophysiological terms as carefully as Strübing. Both of the former names were given to the disease, which is generally referred to as the Marchiafava-Micheli Anemia. William Crosby, who in 1951 in a historical review of PHN first pointed out the pioneering achievement of Strübing, suggested that it was mainly due to the lack of the right "intellectual climate" at the time that so little attention was paid to his work. Still another important aspect of the early history of PNH will be described in the present paper. The analysis of Strübing's publications leads to the conclusion that he was only able to make his important contribution to medical science because he not only had the appropriate clinical setting but also the scientific backup of the famous physiologist Leonhard Landois and his institute at the University of Greifswald, which is an excellent example of scientific progress through cooperation between a clinician and a research scientist.

  15. Inter-rater reliability of data elements from a prototype of the Paul Coverdell National Acute Stroke Registry

    PubMed Central

    Reeves, Mathew J; Mullard, Andrew J; Wehner, Susan

    2008-01-01

    Background The Paul Coverdell National Acute Stroke Registry (PCNASR) is a U.S. based national registry designed to monitor and improve the quality of acute stroke care delivered by hospitals. The registry monitors care through specific performance measures, the accuracy of which depends in part on the reliability of the individual data elements used to construct them. This study describes the inter-rater reliability of data elements collected in Michigan's state-based prototype of the PCNASR. Methods Over a 6-month period, 15 hospitals participating in the Michigan PCNASR prototype submitted data on 2566 acute stroke admissions. Trained hospital staff prospectively identified acute stroke admissions, abstracted chart information, and submitted data to the registry. At each hospital 8 randomly selected cases were re-abstracted by an experienced research nurse. Inter-rater reliability was estimated by the kappa statistic for nominal variables, and intraclass correlation coefficient (ICC) for ordinal and continuous variables. Factors that can negatively impact the kappa statistic (i.e., trait prevalence and rater bias) were also evaluated. Results A total of 104 charts were available for re-abstraction. Excellent reliability (kappa or ICC > 0.75) was observed for many registry variables including age, gender, black race, hemorrhagic stroke, discharge medications, and modified Rankin Score. Agreement was at least moderate (i.e., 0.75 > kappa ≥; 0.40) for ischemic stroke, TIA, white race, non-ambulance arrival, hospital transfer and direct admit. However, several variables had poor reliability (kappa < 0.40) including stroke onset time, stroke team consultation, time of initial brain imaging, and discharge destination. There were marked systematic differences between hospital abstractors and the audit abstractor (i.e., rater bias) for many of the data elements recorded in the emergency department. Conclusion The excellent reliability of many of the data elements

  16. Mechanical Mixing and Metamorphism of Mafic and Ultramafic Lithologies during Mylonisis at the ST. Paul Transform System, Mid-Atlantic Ridge

    NASA Astrophysics Data System (ADS)

    Adrião, Á.; Maia, M.; Hemond, C.; Kaczmarek, M. A.; Briais, A.; Vincent, C.; Brunelli, D.

    2017-12-01

    The St. Paul Transform System offsets by 630 km the Equatorial Mid Atlantic Ridge at 1° N. It consists of four major faults separating three intra transform ridge axes. This region shows a transition from a transpressive, hot spot affected, regional-scale shear zone to the North to a region dominated by a particular oceanic core complex spreading to the South (Vincent et al., this congress). Samples collected in the region during the COLMEIA cruise (Maia et al., 2016) were studied for textures and whole-rock major and trace element contents. All samples experienced pervasive deformation at ductile to brittle conditions overprinted by late low-T alteration. Mylonitic and ultramylonitic rocks can be grouped in three main types: peridotitic, gabbroic and talc-chlorite schist. Peridotitic ultramylonites preserve few opx, cpx and sp porphyroclasts; they have homogeneous nano-micro grain size groundmass, banded foliation and late amphibole and sulfide crystallization. Locally S-C fabric overprints the mylonitic texture. Micro cracks, filled with serpentine, chlorite and oxides are common, as well fluid inclusions trails in olivine and plagioclase crystals of peridotite and gabbros respectively. Major and trace element content of the peridotitic mylonites plot in the depleted field of the abyssal peridotites; however, they present marked LREE enrichment and Eu positive anomaly. Gabbroic and talc-chlorite mylonites display REE-enriched patterns (up to 100x CI) and variable Eu anomalies. Major elements show a remarkable linear trend in the talc-chlorite group suggesting mixing of pure talc and chlorite end-members. These compositional characteristics suggest variable assimilation of MORB and E-MORB during mylonisis or early melt-rock interaction and hydrothermal evolution at variable metamorphic conditions. Vincent et al., 2017. Particular Oceanic Core Complex evolution …; this congress Maia et al., 2016. Extreme mantle uplift and exhumation ... Nat. Geo. doi:10

  17. A. Paul Alivisatos

    Science.gov Websites

    Chancellor for Research Professor & Samsung Distinguished Chair in Nanoscience and Nanotechnology Research Department of Chemistry and Materials Science and Engineering University of California, Berkeley

  18. Paul Schwabe | NREL

    Science.gov Websites

    modeling and data analysis Education M.S. in applied economics and finance, University of California at . Arent, 2012. Mobilizing Public Markets to Finance Renewable Energy Projects: Insights from Expert

  19. Pauls Stradins | NREL

    Science.gov Websites

    Materials Photovoltaics group. In addition, it involves theory, analytical microscopy, and atomic layer and Technology, his Ph.D. from the Latvian Institute of Physics, then spent five years in Professor Fritzche's group at the University of Chicago followed by another five years in the Thin-Film Si Solar Cells

  20. The Modern Catholic Just War Tradition

    DTIC Science & Technology

    2012-04-15

    offered a positive solution to the problems facing humanity. In fact in an address to the Vatican Diplomatic Corps, January 13, 2003, Pope John Paul II...cii Pope John Paul II. “Address of His Holiness Pope John Paul II to the Diplomatice Corps.” Speech to the Vatican Diplomatic Corps Libreria...the Vatican Diplomatic Corps Libreria Editrice Vaticana, January 2003. 4 http://www.vatican.va/holy_father/john_paul_ii/speeches/2003/january

  1. Proceedings of the 2009 Antenna Applications Symposium held in Monticello, Illinois on 22-24 September 2009. Volume 1

    DTIC Science & Technology

    2009-12-12

    Circuit Design, Theory and Applications. Prentice-Hall, 1 ed., 2000. 39 MEASUREMENT OF ELECTRICALLY SMALL ANTENNAS Suhail Barot, Paul E. Mayes, Paul ...2] “Ansoft HFSS, Version 9.2.1,” Ansoft Corporation, Pittsburgh, PA. 50 REDUCED-SIZE LINEAR ANTENNA ELEMENTS Paul E. Mayes, Paul W. Klock and...structures," IRE Internation convention, vol. 5, pp. 119-129, Mar 1957. [2] K. M. P. Aghdam, R. Faraji- Dana , and J. Rashed-Mohassel, "Compact dual

  2. [Surgical approach of traumatic urethral injury in children. Experience at San Vicente of Paul Universitary Hospital. Medellín 1987-2007].

    PubMed

    Martínez Montoya, Jorge A; Tascón Acevedo, Natalia M

    2009-04-01

    In order to evaluate the efficacy of different surgical techniques for the correction of traumatic lesions of the urethra, we performed a retrospective study in those patients, and evaluated different complications such as postsurgical stenosis of the urethra, incontinence and impotence (erectile dysfunction). A retrospective study was conducted, reviewing the clinical charts of 43 patients admitted to the San Vicente of Paul Hospital, with diagnosis of traumatic rupture of the posterior urethra from 1987 to 2007. We analyzed different demographic data, type of surgical correction, early and late complications. The average age of the patients was 7.7 years, the average follow up was 30.6 months, and all the patients were male with a posterior urethral rupture. 27 Patients underwent a primary urethral repair (63%), 13 patients underwent a cistostomy with later urologic reconstruction (30%), in 3 patients (7%) other surgical procedures were made. Overall complication rate was 39.5%. These complications were: Urethral stenosis, 26 patients (60.5%), urinary retention secondary to obstruction, 10 patients (23.3%), incontinence 10 patients (23.3%) and impotence 7 patients (16.3%). Patients treated with a primary urethral repair presented a significantly less development of infection, obstruction and stenosis, (p<0.05). Patients with pelvis fracture associated to urethral trauma had a significant higher risk of developing stenosis and impotence. (p<0.05). Both different surgical techniques compared showed a similar complication and morbidity rates in middle follow up. Each procedure should be selected according to clinical condition of the patient, the extension of the urethral damage, the associated traumatic lesions and the surgeon's expertise. In our searched patients, treated with a primary urethral repair we found a significantly less development of infection, obstruction and stenosis.

  3. A Perspective on Research Challenges in Information Security

    DTIC Science & Technology

    2011-11-01

    UNCLASSIFIED A Perspective on Research Challenges in Information Security Tamas Abraham, David Adie, Angela Billard, Paul Buckland, Michael Frangos ...Abstract (U) 4. AUTHORS Tamas Abraham, David Adie, Angela Billard, Paul Buckland, Michael Frangos , Ben Long, Mar- tin Lucas, Paul Montague, Dean Philp

  4. 63. Photocopy of photograph (original print in the Minnesota Historical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. Photocopy of photograph (original print in the Minnesota Historical Society, St. Paul, Minnesota, 1958. #31008. Photographer: St. Paul Dispatch-Pioneer Press.) AERIAL VIEW OF HIGH BRIDGE, LOOKING SOUTHWEST, 1958 - Smith Avenue High Bridge, Smith Avenue between Cherokee Avenue & Cliff Street, Saint Paul, Ramsey County, MN

  5. 68. Photocopy of photograph (original print in the Minnesota Historical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    68. Photocopy of photograph (original print in the Minnesota Historical Society, St. Paul, Minnesota, 1924. #35108. Photographer: St. Paul Daily News.) VIEW TO EAST, SHOWING SPAN NOS. 10-20, 1924 - Smith Avenue High Bridge, Smith Avenue between Cherokee Avenue & Cliff Street, Saint Paul, Ramsey County, MN

  6. 78 FR 59317 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Revision to Emission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... for R. Paul Smith Power Station; Withdrawal of Proposed Rule AGENCY: Environmental Protection Agency... revision pertains to revised emission limitations for the R. Paul Smith Power Station located in Washington... action to approve the revised emission limitations for the R. Paul Smith Power Station contained in the...

  7. 75 FR 34670 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Revision to Emission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... Promulgation of Air Quality Implementation Plans; Maryland; Revision to Emission Limitations for R. Paul Smith... revision pertains to revised emission limitations for the R. Paul Smith Power Station located in Washington... R. Paul Smith Power Station in Washington County. This facility had annual nitrogen oxides (NOx...

  8. [The impartiality of ignorance? - A controversy between Paul Julius Möbius and Julius Wagner-Jauregg on the symptoms of reanimated persons after a suicide attempt through self-hanging].

    PubMed

    Engmann, B; Steinberg, H

    2014-05-01

    Between 1891 and 1893 the famous Austrian and German neuropsychiatrists Julius Wagner-Jauregg and Paul Julius Möbius disputed in leading German and Austrian medical journals about mental and physiological changes and symptoms in people who after strangulation could be revived in time to survive. Their dispute even touched personal issues. For the study, the original sources were studied and contrasted with relevant secondary sources. The dispute was mainly about two opposing concepts: On the one hand, Wagner-Jauregg supported an organic, neurological concept; on the other hand a psychoreactive-symptoms concept represented by Möbius and elaborated by him first in his concept of hysteria. The study elaborates these factual differences in completely different approaches to psychiatry and - at least in the case of Möbius - how a medical theory was embedded into a pre-existing philosophical system. The dispute studied discusses a philosophical problem which has remained incompletely understood until the present day - the relationship of body and mind. Hence the study on this dispute is more than just an interesting aspect in the history of sciences, but rather the illustration of a meeting of two opponents in a still relevant discussion. © Georg Thieme Verlag KG Stuttgart · New York.

  9. 67. Photocopy of photograph (original print in the Minnesota Historical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    67. Photocopy of photograph (original print in the Minnesota Historical Society, St. Paul Minnesota, ca. 1925. #35109. Photographer: St. Paul Daily News.) VIEW TO NORTHEAST, SHOWING SPAN NOS. 9-19, ca. 1925 - Smith Avenue High Bridge, Smith Avenue between Cherokee Avenue & Cliff Street, Saint Paul, Ramsey County, MN

  10. Partnering for Environmental Security Cooperation in Central Asia and the Caspian Basin

    DTIC Science & Technology

    2002-04-01

    Organizations.......................................................................................98 Mr. Paul Giannone Disaster Response Planning Processes...Paul Giannone of CARE USA who discussed key points of Non-governmental Organizations’ relationships with the military and provided suggestions on...Relationships between Military and Civilian Organizations Mr. Paul Giannone Disaster Response Planning Processes and Procedures Mr. Wolfgang G

  11. 31. Photocopy of line illustration; originally published in William N. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Photocopy of line illustration; originally published in William N. Carey, 'St. Paul Builds an Airport One Mile From Post Office,' Engineering News-Record, (August 21, 1930), figure 6, page 294; SHOWS CANTILEVERED ROOF-TRUSS SYSTEM OF MUNICIPAL HANGAR COMPLETED AT ST. PAUL MUNICIPAL AIRPORT IN 1930; THE STRUCTURAL DESIGN WAS BASED ON THAT OF THE NORTHWEST AIRWAYS HANGAR, EXCEPT FOR THE SUBSTITUTION OF BOWSTRING TRUSSES FOR TRAPEZOIDAL TRUSSES - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

  12. 72. Photocopy of photograph (original print in the Minnesota Historical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. Photocopy of photograph (original print in the Minnesota Historical Society, St. Paul, Minnesota, June 25, 1958. #31024. Photographer: St. Paul Dispatch-Pioneer Press. VIEW TO SOUTH, SHOWING THE RESURFACING OF THE BRIDGE IN 1958 - Smith Avenue High Bridge, Smith Avenue between Cherokee Avenue & Cliff Street, Saint Paul, Ramsey County, MN

  13. 64. Photocopy of photograph (original print in the Minnesota Historical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    64. Photocopy of photograph (original print in the Minnesota Historical Society, St. Paul Minnesota, ca. 1891. #35805. Photographer: Haynes and Bros., St. Paul.) VIEW TO SOUTH, SHOWING FOUR PERCENT GRADE OF HIGH BRIDGE, ca. 1981 - Smith Avenue High Bridge, Smith Avenue between Cherokee Avenue & Cliff Street, Saint Paul, Ramsey County, MN

  14. 76 FR 18725 - Marine Mammals; File Nos. 14330 and 14335

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... (Phoca vitulina) on St. Paul, St. George, Otter, and Walrus Islands, and Sea Lion Rock, all of the... marine mammals in Alaska: (File No. 14330) the Aleut Community of St. Paul Island, Tribal Government, Ecosystem Conservation Office, St. Paul Island, AK; and (File No. 14335) the Alaska SeaLife Center, Seward...

  15. 76 FR 24840 - Safety Zone; 2011 Rohto Ironman 70.3 Miami, Biscayne Bay, Miami, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... Lieutenant Paul A. Steiner, Sector Miami Prevention Department, Coast Guard; telephone 305-535-8724, e-mail Paul.A.Steiner@uscg.mil . If you have questions on viewing or submitting material to the docket, call... Lieutenant Paul A. Steiner, Sector Miami Prevention Department, Coast Guard; telephone 305-535-8724, e-mail...

  16. 76 FR 9278 - Safety Zone; Fourth Annual Offshore Challenge, Sunny Isles Beach, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... Lieutenant Paul A. Steiner, Sector Miami Prevention Department, Coast Guard; telephone 305-535-8724, e-mail Paul.A.Steiner@uscg.mil . If you have questions on viewing or submitting material to the docket, call.... Steiner, Sector Miami Prevention Department, Coast Guard; telephone 305-535- 8724, e-mail Paul.A.Steiner...

  17. 78 FR 28633 - Prometric, Inc., a Subsidiary of Educational Testing Service, Including On-Site Leased Workers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... Subsidiary of Educational Testing Service, Including On-Site Leased Workers From Office Team St. Paul... Office Team were employed on-site at the St. Paul, Minnesota location of the subject firm. The Department... workers leased from Office Team working on- site at the St. Paul, Minnesota location of Prometric, Inc., a...

  18. Lack of Healthy Food in Small-Size to Mid-Size Retailers Participating in the Supplemental Nutrition Assistance Program, Minneapolis-St. Paul, Minnesota, 2014.

    PubMed

    Laska, Melissa N; Caspi, Caitlin E; Pelletier, Jennifer E; Friebur, Robin; Harnack, Lisa J

    2015-08-27

    The US Department of Agriculture has stocking criteria for healthy foods among Supplemental Nutrition Assistant Program (SNAP)-authorized retailers. Increased access to healthy food could improve diet quality among SNAP participants, which has implications for chronic disease prevention. The objective of this study was to quantify healthy foods stocked in small-size to mid-size retailers who are authorized under SNAP but not under the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). We used formative, cross-sectional data from a large policy evaluation to conduct secondary analyses. Store audits were conducted in 2014 in 91 randomly selected, licensed food stores in Minneapolis and St. Paul, Minnesota. Supermarkets and retailers participating in WIC, which are required to stock healthy foods, were excluded as were other stores not reasonably expected to stock staple foods, such as specialty stores or produce stands. Availability of milk, fruits, vegetables, and whole-grain-rich foods was assessed. The 91 stores studied were corner stores, food-gas marts, dollar stores, and pharmacies. More than half carried 1 or more varieties of fat-free or low-fat milk, fresh or canned fruit, and whole-grain-rich cereal. However, only one-third stocked 1 or more varieties of fresh vegetables and only one-quarter stocked whole-grain-rich products, such as whole-grain-rich bread (26%) or tortillas (21%) or brown rice (25%). Few stores stocked at least 2 varieties of each product. Many stores did not stock a variety of healthy foods. The US Department of Agriculture should change policies to improve minimum stocking requirements for SNAP-authorized retailers.

  19. Lack of Healthy Food in Small-Size to Mid-Size Retailers Participating in the Supplemental Nutrition Assistance Program, Minneapolis–St. Paul, Minnesota, 2014

    PubMed Central

    Caspi, Caitlin E.; Pelletier, Jennifer E.; Friebur, Robin; Harnack, Lisa J.

    2015-01-01

    Introduction The US Department of Agriculture has stocking criteria for healthy foods among Supplemental Nutrition Assistant Program (SNAP)-authorized retailers. Increased access to healthy food could improve diet quality among SNAP participants, which has implications for chronic disease prevention. The objective of this study was to quantify healthy foods stocked in small-size to mid-size retailers who are authorized under SNAP but not under the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Methods We used formative, cross-sectional data from a large policy evaluation to conduct secondary analyses. Store audits were conducted in 2014 in 91 randomly selected, licensed food stores in Minneapolis and St. Paul, Minnesota. Supermarkets and retailers participating in WIC, which are required to stock healthy foods, were excluded as were other stores not reasonably expected to stock staple foods, such as specialty stores or produce stands. Availability of milk, fruits, vegetables, and whole-grain–rich foods was assessed. Results The 91 stores studied were corner stores, food–gas marts, dollar stores, and pharmacies. More than half carried 1 or more varieties of fat-free or low-fat milk, fresh or canned fruit, and whole-grain–rich cereal. However, only one-third stocked 1 or more varieties of fresh vegetables and only one-quarter stocked whole-grain–rich products, such as whole-grain-rich bread (26%) or tortillas (21%) or brown rice (25%). Few stores stocked at least 2 varieties of each product. Conclusions Many stores did not stock a variety of healthy foods. The US Department of Agriculture should change policies to improve minimum stocking requirements for SNAP-authorized retailers. PMID:26312380

  20. Cancer, viruses, and mass migration: Paul Berg's venture into eukaryotic biology and the advent of recombinant DNA research and technology, 1967-1980.

    PubMed

    Yi, Doogab

    2008-01-01

    The existing literature on the development of recombinant DNA technology and genetic engineering tends to focus on Stanley Cohen and Herbert Boyer's recombinant DNA cloning technology and its commercialization starting in the mid-1970s. Historians of science, however, have pointedly noted that experimental procedures for making recombinant DNA molecules were initially developed by Stanford biochemist Paul Berg and his colleagues, Peter Lobban and A. Dale Kaiser in the early 1970s. This paper, recognizing the uneasy disjuncture between scientific authorship and legal invention in the history of recombinant DNA technology, investigates the development of recombinant DNA technology in its full scientific context. I do so by focusing on Stanford biochemist Berg's research on the genetic regulation of higher organisms. As I hope to demonstrate, Berg's new venture reflected a mass migration of biomedical researchers as they shifted from studying prokaryotic organisms like bacteria to studying eukaryotic organisms like mammalian and human cells. It was out of this boundary crossing from prokaryotic to eukaryotic systems through virus model systems that recombinant DNA technology and other significant new research techniques and agendas emerged. Indeed, in their attempt to reconstitute 'life' as a research technology, Stanford biochemists' recombinant DNA research recast genes as a sequence that could be rewritten thorough biochemical operations. The last part of this paper shifts focus from recombinant DNA technology's academic origins to its transformation into a genetic engineering technology by examining the wide range of experimental hybridizations which occurred as techniques and knowledge circulated between Stanford biochemists and the Bay Area's experimentalists. Situating their interchange in a dense research network based at Stanford's biochemistry department, this paper helps to revise the canonized history of genetic engineering's origins that emerged during

  1. 28. Photocopy of photograph dated ca. 1940; photographer unknown; original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Photocopy of photograph dated ca. 1940; photographer unknown; original filed as MR2.9/SP8/r373 in Audio-Visual Collection of Minnesota Historical Society, St. Paul; WEST SIDE AFTER SECOND-STORY ADDITION; LOOKING EAST - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

  2. 16TH Annual Review of Progress in Applied Computational Electromagnetics of the Naval Postgraduate School, Monterey, CA. Volume I

    DTIC Science & Technology

    2000-03-24

    Element Method for Designing Plasma Reactors" Leo Kempel, Paul Rummel, Tim Grotjohn and John Amrhein ............................................ 28...34Finite Element Method for Designing Plasma Reactors" Leo Kempel, Paul Rummel, Tim Grotjohn and John Amrhein...548 "lime-Domain Simulation of Electromagnetic Wave Propagation in a Magnetized Plasma" J. Paul , C. Christopoulos, and

  3. The Incalculable Benefits of Revitalizing Your Board

    ERIC Educational Resources Information Center

    Holtschneider, Dennis H.

    2013-01-01

    DePaul University has grown in size and stature in the last decade. Chicago's "little school under the El," as DePaul was once known, is now the nation's largest Catholic university and the largest private, nonprofit university in the Midwest. DePaul University restructured its board, enabling it to play an important role in the…

  4. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-221) Project #: V-O-04/10 - Paul-Allston No 1 and 2 - 500 kV Transmission Line Corridor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stratton, Elaine S.

    2004-07-26

    The project activities will be conducted along the Right-of-Way (ROW) of the Paul-Allston No 1 and 2 - 500 kV transmission line corridor between towers 45/4 and the Allston substation. This corridor includes portions of the Longview-Allston No 1 and 2 and the Longview-Allston No 3 and 4 - 230 kV transmission lines. The corridor along this section of the proposed project varies between 125 and 150 feet in width and crosses approximately 4 miles of terrain from Longview, Washington crossing the Columbia River and passing through rural forestland and pasture lands to the Allston Substation in Oregon. BPA proposesmore » to remove unwanted vegetation along the right-of-way, along access roads and around tower structures along the subject transmission line corridor that may impede the operation and maintenance of the identified transmission lines. BPA plans to conduct vegetation control with the goal of removing tall growing vegetation that is currently or will soon be a hazard to the transmission line. BPA’s overall goal is to have low-growing plant communities along the rights-of-way to control the development of potentially threatening vegetation.« less

  5. 26. Photocopy of photograph dated 1930; photographer unknown; original filed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Photocopy of photograph dated 1930; photographer unknown; original filed as MR2.9/SP8/p343 in Audio-Visual Collection of Minnesota Historical Society, St. Paul; THREE-QUARTER VIEW SHOWING WEST SIDE AND SOUTH FRONT SHORTLY AFTER COMPLETION; LOOKING NORTHEAST - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

  6. 27. Photocopy of photograph dated ca. 1940; photographer unknown; original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Photocopy of photograph dated ca. 1940; photographer unknown; original filed as MR2.9/SP8/r374 in Audio-Visual Collection Minnesota Historical Society, St. Paul; THREE-QUARTER VIEW SHOWING WEST SIDE AND SOUTH FRONT AFTER SECOND-STORY ADDITION; LOOKING NORTHEAST - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

  7. 29. Photocopy of photograph dated 1930; photographer unknown; original filed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Photocopy of photograph dated 1930; photographer unknown; original filed as HE17/p7 in Audio-Visual Collection of Minnesota Historical Society, St. Paul; HANGAR AREA, INTERIOR, SHOWING LONGITUDINAL 'CARRYING' TRUSS AND CANTILEVERED SECTION OF ROOF TRUSSES; LOOKING NORTHWEST FROM SOUTHEAST FRONT CORNER - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

  8. Religion in the Locker Room

    ERIC Educational Resources Information Center

    Price, Sean

    2013-01-01

    In September 2011, Paul Phillips stepped out of his football team's field house and into a struggle over the separation of church and state. Like most teams, Paul's practiced after school. But one day he found that the coach had called in a local minister to conduct a weekly half-hour "team chapel" before practice. Paul, who does not believe in…

  9. Ultrasonically Activated Diffusion Bonding for Fluidic Control Assembly

    DTIC Science & Technology

    1979-02-01

    CONTROL ASSEMBLY SONOBOND CORPORATION SUBSIDIARY OF CHRISTIAN METALS CORPORATION WEST CHESTER, PENNSYLVANIA HOWARD A. SCHEETZ PAUL L. COPPA JANET...FLUIDIC CONTROL ASSEMBLY Howard A. Scheetz Paul L. Coppa Janet Devine Sonobond Corporation Subsidiary of Christiana Metals Corporation West... Paul L. Coppa Janet Devine fl. CONTRACT OR GRANT NUMBERS.) Contract No. DAAA21-76-C-0136 ». PERFORMING ORGANIZATION N AM t AND ADDRESS

  10. Proceedings of the Conference on the Design of Experiments in Army Research Development and Testing (34th) Held in Las Cruces, New Mexico on 19-21 October 1988

    DTIC Science & Technology

    1989-07-01

    Webb and Linda L.C. Moss.............,,...,....., 27 COMPARISON OF RELIABILITY CONFIDENCE INTERVALS Paul H . Thrasher. ......... . 0 1...Webb and Linda L.C. Moss, U.S. Army Ballistic Research Laboratory COMPARISON OF RELIABILITY CONFIDENCE INTERVALS Paul H. Thrasher, White Sands Missile...RELEVANT Paul H. Thrasher, White Sands Missile Range 0930 - 1000 BREAK 1000 - 1130 GENERAL SESSION III Chairperson: Douglas B. Tang, Valter Reed Army

  11. Development of a Robust Static Punch Experiment for Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material

    DTIC Science & Technology

    2014-09-01

    Cross-Ply Material by David Gray, Robert Kaste , and Paul Moy ARL-TR-7090 September 2014...Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material David Gray, Robert Kaste , and Paul...ELEMENT NUMBER 6. AUTHOR(S) David Gray, Robert Kaste , and Paul Moy 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7

  12. From powerful research platform for industrial EUV photoresist development, to world record resolution by photolithography: EUV interference lithography at the Paul Scherrer Institute

    NASA Astrophysics Data System (ADS)

    Buitrago, Elizabeth; Fallica, Roberto; Fan, Daniel; Karim, Waiz; Vockenhuber, Michaela; van Bokhoven, Jeroen A.; Ekinci, Yasin

    2016-09-01

    Extreme ultraviolet interference lithography (EUV-IL, λ = 13.5 nm) has been shown to be a powerful technique not only for academic, but also for industrial research and development of EUV materials due to its relative simplicity yet record high-resolution patterning capabilities. With EUV-IL, it is possible to pattern high-resolution periodic images to create highly ordered nanostructures that are difficult or time consuming to pattern by electron beam lithography (EBL) yet interesting for a wide range of applications such as catalysis, electronic and photonic devices, and fundamental materials analysis, among others. Here, we will show state-of the-art research performed using the EUV-IL tool at the Swiss Light Source (SLS) synchrotron facility in the Paul Scherrer Institute (PSI). For example, using a grating period doubling method, a diffraction mask capable of patterning a world record in photolithography of 6 nm half-pitch (HP), was produced. In addition to the description of the method, we will give a few examples of applications of the technique. Well-ordered arrays of suspended silicon nanowires down to 6.5 nm linewidths have been fabricated and are to be studied as field effect transistors (FETs) or biosensors, for instance. EUV achromatic Talbot lithography (ATL), another interference scheme that utilizes a single grating, was shown to yield well-defined nanoparticles over large-areas with high uniformity presenting great opportunities in the field of nanocatalysis. EUV-IL is in addition, playing a key role in the future introduction of EUV lithography into high volume manufacturing (HVM) of semiconductor devices for the 7 and 5 nm logic node (16 nm and 13 nm HP, respectively) and beyond while the availability of commercial EUV-tools is still very much limited for research.

  13. Paul Coverdell National Acute Stroke Registry Surveillance - four states, 2005-2007.

    PubMed

    George, Mary G; Tong, Xin; McGruder, Henraya; Yoon, Paula; Rosamond, Wayne; Winquist, Andrea; Hinchey, Judith; Wall, Hilary K; Pandey, Dilip K

    2009-11-06

    Each year, approximately 795,000 persons in the United States experience a new or recurrent stroke. Data from the prototype phase (2001-2004) of the Paul Coverdell National Acute Stroke Registry (PCNASR) suggested that numerous acute stroke patients did not receive treatment according to established guidelines. This report summarizes PCNASR data collected during 2005-2007 from Georgia, Illinois, Massachusetts, and North Carolina, the first states to have PCNASRs implemented in and led by state health departments. PCNASR was established by CDC in 2001 to track and improve the quality of hospital-based acute stroke care. The prototype phase (2001-2004) registries were led by CDC-funded clinical investigators in academic and medical institutions, whereas the full implementation of the 2005-2007 statewide registries was led by CDC-funded state health departments. Health departments in each state recruit hospitals to collect data. To be included in PCNASR, patients must be aged >or=18 years and have a clinical diagnosis of acute ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, or transient ischemic attack (TIA) or an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code indicative of a stroke or TIA. Data for patients who are already hospitalized at the time of stroke are not included. The following 10 performance measures of care, based on established guidelines for care of acute stroke patients, were developed by CDC in partnership with neurologists who specialize in stroke care: 1) received deep venous thrombosis prophylaxis, 2) received antithrombotic therapy at discharge, 3) received anticoagulation therapy for atrial fibrillation, 4) received tissue plasminogen activator (among eligible patients), 5) received antithrombotic therapy within 48 hours of admission or by the end of the second hospital day, 6) received lipid level testing, 7) received dysphagia screening, 8) received stroke education, 9

  14. Asterless Licenses Daughter Centrioles to Duplicate for the First Time in Drosophila Embryos

    PubMed Central

    Novak, Zsofia A.; Conduit, Paul T.; Wainman, Alan; Raff, Jordan W.

    2014-01-01

    Summary Centrioles form centrosomes and cilia, and defects in any of these three organelles are associated with human disease [1]. Centrioles duplicate once per cell cycle, when a mother centriole assembles an adjacent daughter during S phase. Daughter centrioles cannot support the assembly of another daughter until they mature into mothers during the next cell cycle [2–5]. The molecular nature of this daughter-to-mother transition remains mysterious. Pioneering studies in C. elegans identified a set of core proteins essential for centriole duplication [6–12], and a similar set have now been identified in other species [10, 13–18]. The protein kinase ZYG-1/Sak/Plk4 recruits the inner centriole cartwheel components SAS-6 and SAS-5/Ana2/STIL, which then recruit SAS-4/CPAP, which in turn helps assemble the outer centriole microtubules [19, 20]. In flies and humans, the Asterless/Cep152 protein interacts with Sak/Plk4 and Sas-4/CPAP and is required for centriole duplication, although its precise role in the assembly pathway is unclear [21–24]. Here, we show that Asl is not incorporated into daughter centrioles as they assemble during S phase but is only incorporated once mother and daughter separate at the end of mitosis. The initial incorporation of Asterless (Asl) is irreversible, requires DSas-4, and, crucially, is essential for daughter centrioles to mature into mothers that can support centriole duplication. We therefore propose a “dual-licensing” model of centriole duplication, in which Asl incorporation provides a permanent primary license to allow new centrioles to duplicate for the first time, while centriole disengagement provides a reduplication license to allow mother centrioles to duplicate again. PMID:24835456

  15. Asterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos.

    PubMed

    Novak, Zsofia A; Conduit, Paul T; Wainman, Alan; Raff, Jordan W

    2014-06-02

    Centrioles form centrosomes and cilia, and defects in any of these three organelles are associated with human disease [1]. Centrioles duplicate once per cell cycle, when a mother centriole assembles an adjacent daughter during S phase. Daughter centrioles cannot support the assembly of another daughter until they mature into mothers during the next cell cycle [2-5]. The molecular nature of this daughter-to-mother transition remains mysterious. Pioneering studies in C. elegans identified a set of core proteins essential for centriole duplication [6-12], and a similar set have now been identified in other species [10, 13-18]. The protein kinase ZYG-1/Sak/Plk4 recruits the inner centriole cartwheel components SAS-6 and SAS-5/Ana2/STIL, which then recruit SAS-4/CPAP, which in turn helps assemble the outer centriole microtubules [19, 20]. In flies and humans, the Asterless/Cep152 protein interacts with Sak/Plk4 and Sas-4/CPAP and is required for centriole duplication, although its precise role in the assembly pathway is unclear [21-24]. Here, we show that Asl is not incorporated into daughter centrioles as they assemble during S phase but is only incorporated once mother and daughter separate at the end of mitosis. The initial incorporation of Asterless (Asl) is irreversible, requires DSas-4, and, crucially, is essential for daughter centrioles to mature into mothers that can support centriole duplication. We therefore propose a "dual-licensing" model of centriole duplication, in which Asl incorporation provides a permanent primary license to allow new centrioles to duplicate for the first time, while centriole disengagement provides a reduplication license to allow mother centrioles to duplicate again. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  16. Identification of AUXIN RESPONSE FACTOR gene family from Prunus sibirica and its expression analysis during mesocarp and kernel development.

    PubMed

    Niu, Jun; Bi, Quanxin; Deng, Shuya; Chen, Huiping; Yu, Haiyan; Wang, Libing; Lin, Shanzhi

    2018-01-24

    Auxin response factors (ARFs) in auxin signaling pathway are an important component that can regulate the transcription of auxin-responsive genes involved in almost all aspects of plant growth and development. To our knowledge, the comprehensive and systematic characterization of ARF genes has never been reported in Prunus sibirica, a novel woody biodiesel feedstock in China. In this study, we identified 14 PsARF genes with a perfect open reading frame (ORF) in P. sibirica by using its previous transcriptomic data. Conserved motif analysis showed that all identified PsARF proteins had typical DNA-binding and ARF domain, but 5 members (PsARF3, 8 10, 16 and 17) lacked the dimerization domain. Phylogenetic analysis of the ARF proteins generated from various plant species indicated that ARFs could be categorized into 4 major groups (Class I, II, III and IV), in which all identified ARFs from P. sibirica showed a closest relationship with those from P. mume. Comparison of the expression profiles of 14 PsARF genes in different developmental stages of Siberian apricot mesocarp (SAM) and kernel (SAK) reflected distinct temporal or spatial expression patterns for PsARF genes. Additionally, based on the expressed data from fruit and seed development of multiple plant species, we identified 1514 ARF-correlated genes using weighted gene co-expression network analysis (WGCNA). And the major portion of ARF-correlated gene was characterized to be involved in protein, nucleic acid and carbohydrate metabolic, transport and regulatory processes. In summary, we systematically and comprehensively analyzed the structure, expression pattern and co-expression network of ARF gene family in P. sibirica. All our findings provide theoretical foundation for the PsARF gene family and will pave the way for elucidating the precise role of PsARF genes in SAM and SAK development.

  17. Selection indicates preference in diverse habitats: A Ground-Nesting bird (charadrius melodus) using reservoir shoreline

    USGS Publications Warehouse

    Anteau, M.J.; Sherfy, M.H.; Wiltermuth, M.T.

    2012-01-01

    Animals use proximate cues to select resources that maximize individual fitness. When animals have a diverse array of available habitats, those selected could give insights into true habitat preferences. Since the construction of the Garrison Dam on the Missouri River in North Dakota, Lake Sakakawea (SAK) has become an important breeding area for federally threatened piping plovers (Charadrius melodus; hereafter plovers). We used conditional logistic regression to examine nest-site selection at fine scales (1, 3, and 10 m) during summers 2006-2009 by comparing characteristics at 351 nests to those of 668 random sites within nesting territories. Plovers selected sites (1 m 2) that were lower than unused random sites, increasing the risk of nest inundation. Plovers selected nest sites that were flat, had little silt, and at least 1 cobble; they also selected for 3-m radius nest areas that were relatively flat and devoid of vegetation and litter. Ninety percent of nests had <38% coverage of silt and <10% slope at the site, and <15% coverage of vegetation or litter and <31% slope within the 3-m radius. Gravel was selected for at nest sites (11% median), but against in the area 10-m from the nest, suggesting plovers select for patches or strips of gravel. Although elevation is rarely evaluated in studies of ground-nesting birds, our results underscore its importance in habitat-selection studies. Relative to where plovers historically nested, habitat at SAK has more diverse topography, substrate composition, vegetation communities, and greater water-level fluctuations. Accordingly, our results provide an example of how habitat-selection results can be interpreted as habitat preferences because they are not influenced by desired habitats being scarce or absent. Further, our results will be useful for directing habitat conservation for plovers and interpreting other habitat-selection studies.

  18. Selection indicates preference in diverse habitats: A ground-nesting bird (Charadrius melodus) using reservoir shoreline

    USGS Publications Warehouse

    Anteau, Michael J.; Sherfy, Mark H.; Wiltermuth, Mark T.

    2012-01-01

    Animals use proximate cues to select resources that maximize individual fitness. When animals have a diverse array of available habitats, those selected could give insights into true habitat preferences. Since the construction of the Garrison Dam on the Missouri River in North Dakota, Lake Sakakawea (SAK) has become an important breeding area for federally threatened piping plovers (Charadrius melodus; hereafter plovers). We used conditional logistic regression to examine nest-site selection at fine scales (1, 3, and 10 m) during summers 2006–2009 by comparing characteristics at 351 nests to those of 668 random sites within nesting territories. Plovers selected sites (1 m2) that were lower than unused random sites, increasing the risk of nest inundation. Plovers selected nest sites that were flat, had little silt, and at least 1 cobble; they also selected for 3-m radius nest areas that were relatively flat and devoid of vegetation and litter. Ninety percent of nests had <38% coverage of silt and <10% slope at the site, and <15% coverage of vegetation or litter and <31% slope within the 3-m radius. Gravel was selected for at nest sites (11% median), but against in the area 10-m from the nest, suggesting plovers select for patches or strips of gravel. Although elevation is rarely evaluated in studies of ground-nesting birds, our results underscore its importance in habitat-selection studies. Relative to where plovers historically nested, habitat at SAK has more diverse topography, substrate composition, vegetation communities, and greater water-level fluctuations. Accordingly, our results provide an example of how habitat-selection results can be interpreted as habitat preferences because they are not influenced by desired habitats being scarce or absent. Further, our results will be useful for directing habitat conservation for plovers and interpreting other habitat-selection studies.

  19. Methane and carbon dioxide exchange in a post-extraction, unrestored peatland in Eastern Quebec, Canada

    NASA Astrophysics Data System (ADS)

    Rankin, Tracy; Strachan, Ian; Strack, Maria

    2017-04-01

    Peatlands, in their pristine state, are important long-term sinks of carbon. The extraction of peat for agricultural purposes or for biofuel leads to a shift in the carbon dynamics. Changes in environmental conditions post extraction may also allow for invasive species to establish and spread across the peatland. Many studies have shown the benefits and advantages of various restoration management practices, but few studies have explored the carbon exchange from unrestored peatlands. Our study reports the methane (CH4) and carbon dioxide (CO2) fluxes from a post-extraction, unrestored peatland in Eastern Québec at both the plant community scale using static chambers, and at the ecosystem scale using an eddy covariance flux tower, over two complete years. Extraction of the Saint-Alexandre-de-Kamouraska peatland (SAK) started in the early 1970's and was halted in 1999. No restoration efforts have been implemented and the remnant ditches remain unblocked. The site consists of sparse patches of Eriophorum and a vast area of bare peat. Consequently, SAK is an overall source of carbon to the atmosphere, releasing an annual total of 153 g C m-2 and 241 g C m-2 in CO2 emissions for 2014 and 2015, respectively, and an average annual total of 1 g C m-2yr-1 in CH4 emissions. Phragmites and Typha, both invasive species, have established themselves in the ditches and are sources of methane; partly explaining the increased emissions in carbon fluxes to the atmosphere post extraction. Results from this study will help managers assess the importance of post-extraction peatland restoration, by comparing the differences in CO2 and CH4 exchange between restored and unrestored peatlands.

  20. Selection indicates preference in diverse habitats: a ground-nesting bird (Charadrius melodus) using reservoir shoreline.

    PubMed

    Anteau, Michael J; Sherfy, Mark H; Wiltermuth, Mark T

    2012-01-01

    Animals use proximate cues to select resources that maximize individual fitness. When animals have a diverse array of available habitats, those selected could give insights into true habitat preferences. Since the construction of the Garrison Dam on the Missouri River in North Dakota, Lake Sakakawea (SAK) has become an important breeding area for federally threatened piping plovers (Charadrius melodus; hereafter plovers). We used conditional logistic regression to examine nest-site selection at fine scales (1, 3, and 10 m) during summers 2006-2009 by comparing characteristics at 351 nests to those of 668 random sites within nesting territories. Plovers selected sites (1 m(2)) that were lower than unused random sites, increasing the risk of nest inundation. Plovers selected nest sites that were flat, had little silt, and at least 1 cobble; they also selected for 3-m radius nest areas that were relatively flat and devoid of vegetation and litter. Ninety percent of nests had <38% coverage of silt and <10% slope at the site, and <15% coverage of vegetation or litter and <31% slope within the 3-m radius. Gravel was selected for at nest sites (11% median), but against in the area 10-m from the nest, suggesting plovers select for patches or strips of gravel. Although elevation is rarely evaluated in studies of ground-nesting birds, our results underscore its importance in habitat-selection studies. Relative to where plovers historically nested, habitat at SAK has more diverse topography, substrate composition, vegetation communities, and greater water-level fluctuations. Accordingly, our results provide an example of how habitat-selection results can be interpreted as habitat preferences because they are not influenced by desired habitats being scarce or absent. Further, our results will be useful for directing habitat conservation for plovers and interpreting other habitat-selection studies.