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Sample records for jen-kun lin editor

  1. New Editor

    NASA Astrophysics Data System (ADS)

    2007-03-01

    It is an honour and a challenge to take up the editorship of the Messenger at this time of ESO's expanding role in European and worldwide astronomy. In order to mark the change, we have made a few adjustments to the appearance without departing from the overall style that Peter Shaver had evolved during his term as editor. I would like to thank Peter for gen-tly coaching me into the position and Jutta Boxheimer, the technical editor, for the high quality of the layout.

  2. TOAD Editor

    NASA Technical Reports Server (NTRS)

    Bingle, Bradford D.; Shea, Anne L.; Hofler, Alicia S.

    1993-01-01

    Transferable Output ASCII Data (TOAD) computer program (LAR-13755), implements format designed to facilitate transfer of data across communication networks and dissimilar host computer systems. Any data file conforming to TOAD format standard called TOAD file. TOAD Editor is interactive software tool for manipulating contents of TOAD files. Commonly used to extract filtered subsets of data for visualization of results of computation. Also offers such user-oriented features as on-line help, clear English error messages, startup file, macroinstructions defined by user, command history, user variables, UNDO features, and full complement of mathematical statistical, and conversion functions. Companion program, TOAD Gateway (LAR-14484), converts data files from variety of other file formats to that of TOAD. TOAD Editor written in FORTRAN 77.

  3. MPS Editor

    NASA Technical Reports Server (NTRS)

    Mathews, William S.; Liu, Ning; Francis, Laurie K.; OReilly, Taifun L.; Schrock, Mitchell; Page, Dennis N.; Morris, John R.; Joswig, Joseph C.; Crockett, Thomas M.; Shams, Khawaja S.

    2011-01-01

    Previously, it was time-consuming to hand-edit data and then set up simulation runs to find the effect and impact of the input data on a spacecraft. MPS Editor provides the user the capability to create/edit/update models and sequences, and immediately try them out using what appears to the user as one piece of software. MPS Editor provides an integrated sequencing environment for users. It provides them with software that can be utilized during development as well as actual operations. In addition, it provides them with a single, consistent, user friendly interface. MPS Editor uses the Eclipse Rich Client Platform to provide an environment that can be tailored to specific missions. It provides the capability to create and edit, and includes an Activity Dictionary to build the simulation spacecraft models, build and edit sequences of commands, and model the effects of those commands on the spacecraft. MPS Editor is written in Java using the Eclipse Rich Client Platform. It is currently built with four perspectives: the Activity Dictionary Perspective, the Project Adaptation Perspective, the Sequence Building Perspective, and the Sequence Modeling Perspective. Each perspective performs a given task. If a mission doesn't require that task, the unneeded perspective is not added to that project's delivery. In the Activity Dictionary Perspective, the user builds the project-specific activities, observations, calibrations, etc. Typically, this is used during the development phases of the mission, although it can be used later to make changes and updates to the Project Activity Dictionary. In the Adaptation Perspective, the user creates the spacecraft models such as power, data store, etc. Again, this is typically used during development, but will be used to update or add models of the spacecraft. The Sequence Building Perspective allows the user to create a sequence of activities or commands that go to the spacecraft. It provides a simulation of the activities and

  4. Journal Editors Celebrated at Editors' Evening

    NASA Astrophysics Data System (ADS)

    Panning, Jeanette

    2014-02-01

    At the Fall Meeting, the premiere social event for AGU's many journal editors is the annual Editors' Evening, an opportunity for members to celebrate and to recognize the efforts of retiring editors. At the event, AGU president Carol Finn welcomed all those in attendance and thanked them for volunteering their time for the benefit of AGU and the wider research community.

  5. DNAAlignEditor: DNA alignment editor tool

    PubMed Central

    Sanchez-Villeda, Hector; Schroeder, Steven; Flint-Garcia, Sherry; Guill, Katherine E; Yamasaki, Masanori; McMullen, Michael D

    2008-01-01

    Background With advances in DNA re-sequencing methods and Next-Generation parallel sequencing approaches, there has been a large increase in genomic efforts to define and analyze the sequence variability present among individuals within a species. For very polymorphic species such as maize, this has lead to a need for intuitive, user-friendly software that aids the biologist, often with naïve programming capability, in tracking, editing, displaying, and exporting multiple individual sequence alignments. To fill this need we have developed a novel DNA alignment editor. Results We have generated a nucleotide sequence alignment editor (DNAAlignEditor) that provides an intuitive, user-friendly interface for manual editing of multiple sequence alignments with functions for input, editing, and output of sequence alignments. The color-coding of nucleotide identity and the display of associated quality score aids in the manual alignment editing process. DNAAlignEditor works as a client/server tool having two main components: a relational database that collects the processed alignments and a user interface connected to database through universal data access connectivity drivers. DNAAlignEditor can be used either as a stand-alone application or as a network application with multiple users concurrently connected. Conclusion We anticipate that this software will be of general interest to biologists and population genetics in editing DNA sequence alignments and analyzing natural sequence variation regardless of species, and will be particularly useful for manual alignment editing of sequences in species with high levels of polymorphism. PMID:18366684

  6. From the Incoming Editors.

    ERIC Educational Resources Information Center

    Reed, W. Michael; Ayersman, David J.

    1999-01-01

    This note from the new editors of the "Journal of Research on Computing in Education" (JRCE) outlines their plans for JRCE during the next three years. Discussion includes the following: review board and associate editors, book reviews, early review, format templates on the JRCE Web site, and special topics and thematic issues. (AEF)

  7. Editors' Fall Picks

    ERIC Educational Resources Information Center

    Hoffert, Barbara; Heilbrun, Margaret; Kuzyk, Raya; Kim, Ann; McCormack, Heather; Katterjohn, Anna; Burns, Ann; Williams, Wilda

    2008-01-01

    From the fall's cascade of great new books, "Library Journal's" editors select their favorites--a dark rendition of Afghan life, a look at the "self-esteem trap," a celebration of Brooklyn activism, and much more.

  8. ISTP CDF Skeleton Editor

    NASA Technical Reports Server (NTRS)

    Chimiak, Reine; Harris, Bernard; Williams, Phillip

    2013-01-01

    Basic Common Data Format (CDF) tools (e.g., cdfedit) provide no specific support for creating International Solar-Terrestrial Physics/Space Physics Data Facility (ISTP/SPDF) standard files. While it is possible for someone who is familiar with the ISTP/SPDF metadata guidelines to create compliant files using just the basic tools, the process is error-prone and unreasonable for someone without ISTP/SPDF expertise. The key problem is the lack of a tool with specific support for creating files that comply with the ISTP/SPDF guidelines. There are basic CDF tools such as cdfedit and skeletoncdf for creating CDF files, but these have no specific support for creating ISTP/ SPDF compliant files. The SPDF ISTP CDF skeleton editor is a cross-platform, Java-based GUI editor program that allows someone with only a basic understanding of the ISTP/SPDF guidelines to easily create compliant files. The editor is a simple graphical user interface (GUI) application for creating and editing ISTP/SPDF guideline-compliant skeleton CDF files. The SPDF ISTP CDF skeleton editor consists of the following components: A swing-based Java GUI program, JavaHelp-based manual/ tutorial, Image/Icon files, and HTML Web page for distribution. The editor is available as a traditional Java desktop application as well as a Java Network Launching Protocol (JNLP) application. Once started, it functions like a typical Java GUI file editor application for creating/editing application-unique files.

  9. A century of editors.

    PubMed

    Riley, R W

    1983-07-01

    They are unalike and far apart, these 13 past editors of The Journal. Between Nathan S. Davis's first issue and William R. Barclay's retirement, there was almost a century of change in medicine, society, the American Medical Association, prose style, and editorial needs. During these years, the editors ranged from the brilliant organizers John B. Hamilton and George H. Simmons to the diligent John H. Hollister and the devoted Johnson F. Hammond. There were editors with the hot determination of James C. Culbertson, John H. Talbott, and Robert H. Moser, and there were those with the cool precision of Austin Smith and Hugh H. Hussey. They varied from Morris Fishbein, who wrote and spoke "with the grade of an eagle in its unhindered soar," to Truman W. Miller, who wrote scarcely a word. Here, briefly, they are together.

  10. PANEL LIBRARY AND EDITOR

    NASA Technical Reports Server (NTRS)

    Raible, E.

    1994-01-01

    The Panel Library and Editor is a graphical user interface (GUI) builder for the Silicon Graphics IRIS workstation family. The toolkit creates "widgets" which can be manipulated by the user. Its appearance is similar to that of the X-Windows System. The Panel Library is written in C and is used by programmers writing user-friendly mouse-driven applications for the IRIS. GUIs built using the Panel Library consist of "actuators" and "panels." Actuators are buttons, dials, sliders, or other mouse-driven symbols. Panels are groups of actuators that occupy separate windows on the IRIS workstation. The application user can alter variables in the graphics program, or fire off functions with a click on a button. The evolution of data values can be tracked with meters and strip charts, and dialog boxes with text processing can be built. Panels can be stored as icons when not in use. The Panel Editor is a program used to interactively create and test panel library interfaces in a simple and efficient way. The Panel Editor itself uses a panel library interface, so all actions are mouse driven. Extensive context-sensitive on-line help is provided. Programmers can graphically create and test the user interface without writing a single line of code. Once an interface is judged satisfactory, the Panel Editor will dump it out as a file of C code that can be used in an application. The Panel Library (v9.8) and Editor (v1.1) are written in C-Language (63%) and Scheme, a dialect of LISP, (37%) for Silicon Graphics 4D series workstations running IRIX 3.2 or higher. Approximately 10Mb of disk space is required once compiled. 1.5Mb of main memory is required to execute the panel editor. This program is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format for an IRIS, and includes a copy of XScheme, the public-domain Scheme interpreter used by the Panel Editor. The Panel Library Programmer's Manual is included on the distribution media. The Panel Library and

  11. Editors' Spring Picks

    ERIC Educational Resources Information Center

    Library Journal, 2011

    2011-01-01

    While they do not represent the rainbow of reading tastes American public libraries accommodate, Book Review editors are a wildly eclectic bunch. One look at their bedside tables and ereaders would reveal very little crossover. This article highlights an eclectic array of spring offerings ranging from print books to an audiobook to ebook apps. It…

  12. LDAP Browser/Editor

    SciTech Connect

    Gawor, Jarek; Laszewski, Gregor von

    2000-07-18

    The LDAP Browser/Editor provides a user-friendly Java-based interface to LDAP databases with tightly integrated browsing and editing capabilities. Entirely written in Java with help of the JFC (Swingset) and JNDI class libraries. It connects to any X.500, LDAP v2 and v3 servers and supports editing of multiple-value attributes.

  13. WRR editor Ronald Cummings

    NASA Astrophysics Data System (ADS)

    1984-04-01

    It has been nearly a year since Ronald Cummings took over as policy sciences editor of Water Resources Research (WRR), and in that time he has worked to make the journal live up to its role as “an interdisciplinary journal integrating research in the social and natural sciences of water.” Cummings takes the “interdisciplinary” part seriously. “I'd like to see a much broader range of policy issues presented to readers,” he says. “I would hope it would then stimulate interchange between our colleagues concerning evolving issues of the '80s and '90s.”Cummings brings a solid background as a resource economist to his 4-year term as editor, which began last January and runs until December 1987. Cummings succeeds Jared Cohon as policy sciences editor. Stephen J. Burges is the WRR editor for hydrological, physical, chemical, and biological sciences. Now a Professor of Economics and Director of the Program in Natural Resources Economics at the University of New Mexico, Cummings is a past president of the Association of Environmental and Resource Economists. He has been a consultant in matters of water resources management, forestry management, and energy policy for more than a decade, working on projects in both the United States and Latin America. Since joining the faculty at New Mexico in 1975, he has, among other things, worked with engineers at the Los Alamos National Laboratory in developing operation'management models for hot, dry rock geothermal systems.

  14. Editors' Fall Picks

    ERIC Educational Resources Information Center

    Heilbrun, Margaret; McCormack, Heather; Katterjohn, Anna; Kuzyk, Raya; Roncevic, Mirela; Fox, Bette-Lee; Hoffert, Barbara

    2009-01-01

    "Library Journal's" review editors select fall titles readers won't want to miss--"Waiting on a Train: The Embattled Future of Passenger Rail Service" (James McCommons); "Happy" (Alex Lemon); "Free for All: Joe Papp, the Public, and the Greatest Theater Story Ever Told" (Kenneth Turan & Joseph Papp); "In My Father's Shadow: A Daughter Remembers…

  15. Meet the APS Journal Editors

    NASA Astrophysics Data System (ADS)

    2016-05-01

    The Editors of the APS journals invite you to join them for conversation. The Editors will be available to answer questions, hear your ideas, and discuss any comments about the journals. All are welcome. Light refreshments will be served.

  16. The Solid Gold Copy Editor.

    ERIC Educational Resources Information Center

    Riblet, Carl, Jr.

    This book discusses the role of the newspaper copy editor on a daily newspaper and contains lessons instructing editors on how to prepare copy for print. The book is specifically designed to polish the skills of the already experienced newspaper copy editor, although a beginner will find the lessons useful and instructive. Contained in the lessons…

  17. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    2000-11-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents The equivalence of mass and energy Peter Stansbury Head of Physics, Christ Church Grammar School, Claremont, Western Australia 6010 Comment on `A simple experiment to study parabolic surfaces' N Gauthier Department of Physics, The Royal Military College of Canada, Kingston, Ontario K7K 7B4, Canada

  18. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1997-03-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Criticisms of hands-on pseudoscience David J Fisher 27 Elderberry Road, Cardiff CF5 3RG, UK Measuring varying fields Don Koks Adelaide University, Australia Relativity at A-level: a comment David Sang 3 Ellasdale Road, Bognor Regis, PO21 2SG, UK

  19. ION Configuration Editor

    NASA Technical Reports Server (NTRS)

    Borgen, Richard L.

    2013-01-01

    The configuration of ION (Inter - planetary Overlay Network) network nodes is a manual task that is complex, time-consuming, and error-prone. This program seeks to accelerate this job and produce reliable configurations. The ION Configuration Editor is a model-based smart editor based on Eclipse Modeling Framework technology. An ION network designer uses this Eclipse-based GUI to construct a data model of the complete target network and then generate configurations. The data model is captured in an XML file. Intrinsic editor features aid in achieving model correctness, such as field fill-in, type-checking, lists of valid values, and suitable default values. Additionally, an explicit "validation" feature executes custom rules to catch more subtle model errors. A "survey" feature provides a set of reports providing an overview of the entire network, enabling a quick assessment of the model s completeness and correctness. The "configuration" feature produces the main final result, a complete set of ION configuration files (eight distinct file types) for each ION node in the network.

  20. EDITORIAL: Editor's Farewell

    NASA Astrophysics Data System (ADS)

    Hudson, R. P.

    1989-01-01

    The completion of Volume 26, 1989, marked the end of my tenure as Editor of Metrologia. My association with the journal, its parent body the Comité International des Poids et Mesures, its host organization the Bureau International des Poids et Mesures, the publishers Springer-Verlag and last (but by no means least) the Editorial Board, has been a pleasant one and I trust that the subscribers will have found the product to be generally satisfactory. There have been, it is true, some disappointments along the way and I shall mention two of these while expressing the hope that the new Editor will enjoy a greater success in their regard. First is the question of circulation, which has stayed dangerously low, although the shrinkage has tapered off in the most recent years. Because of the narrow public support, the costs of production are relatively high and this, through a consequently high subscription rate, tends to enshrine the unsatisfactory state of affairs. Modest schemes to broaden the journal's appeal and bring in a wider readership have foundered upon the first step, namely, that of procuring from staff members of the national standards laboratories the hoped-for articles which would discuss the state of the art in delivering the highest-quality measurement services to the public. However, some very interesting and bolder schemes are presently under discussion. I had also hoped to leaven the journal's content a little by regularly appearing articles on the latest developments within the great national laboratories. But, as with technical review articles, it has proven very difficult to find the right authors who can also spare the time, and only a few laboratories have found it possible to collaborate. In taking my leave, it remains for me to thank all the contributors, referees and readers for their support, to express the hope of an ever brighter future for Metrologia and to wish to the new Editor, Dr D A Blackburn, a happy and successful tenure.

  1. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1997-01-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Software teaching of modular physics: SToMP Stephen Hearn Head of Science, Charterhouse, Godalming, Surrey GU7 2DX Bridging the gap or avoiding a chasm? R W West York Strengths and weaknesses of science John Bausor Christians in Science Education, Edgware, London HA8 6RR Addressing the issues Philip Britton Head of Physics, Leeds Grammar School Modern syllabuses and old textbooks: a useful synthesis Richard Barrass St Mary's College, Doncaster DN1 2ES

  2. The Meta Sketch Editor

    NASA Astrophysics Data System (ADS)

    Nóbrega, Leonel; Nunes, Nuno Jardim; Coelho, Helder

    The Model Driven Development has its foundations on metamodeling and new tools are required in order to support users on the definition and customization of their modeling languages. The MetaSketch Editor takes advantage of the current OMG technology to provide the metamodeling mechanisms required to support the integration of some widely used human-computer interaction (HCI) notation into the UML, through precise and semantically sound metamodeling extensions. With this integration, HCI field could contribute to leverage the model-driven development paradigm and support automatic generation of interactive applications

  3. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1998-03-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Comment on `Magnetic and electric field strengths of high voltage power lines and household appliances' José Luis Giordano Dept. de Ciencia y Tecnología de Materiales y Fluidos, CPSI, Universidad de Zaragoza, Spain Twins paradox S R Carson Norton College, Malton, North Yorkshire, UK On alternative ways of finding the ratio of specific heats of gases Tomas Ficker Physics Department, Technical University of Brno, Czech Republic

  4. Microbial Properties Database Editor Tutorial

    EPA Science Inventory

    A Microbial Properties Database Editor (MPDBE) has been developed to help consolidate microbial-relevant data to populate a microbial database and support a database editor by which an authorized user can modify physico-microbial properties related to microbial indicators and pat...

  5. Editors in the Electronic Age.

    ERIC Educational Resources Information Center

    Dye, Robert M., Ed.

    Intended for newspaper writers and editors, this collection of articles includes the following titles and authors: "VDTs, TV Haven't Shocked Editors" by Jay Rogers; "Opinions Vary on Electronics' Effect" by Bob Nordyke; "A Few Kind Words for the Censors" by Hugh A. Mulligan; "Those Awards Have Their Limitations" by Larry Fortner; "Obituaries Are…

  6. Message from the Editor

    NASA Astrophysics Data System (ADS)

    Stambaugh, Ronald D.

    2014-01-01

    This last year being an odd numbered year, the pages of Nuclear Fusion saw a large influx of expanded papers from the 2012 Fusion Energy Conference in San Diego. Many papers have focused on the scientific and technical challenges posed by ITER. Contributions are steadily increasing from the new superconducting tokamaks in Asia. The ITER Project continues to move ahead. Construction at the Cadarache site is quite remarkable. Buildings completed include the huge Poloidal Field Coils Winding Facility and the Headquarters building, which has been occupied by the ITER staff. Work is progressing on the Assembly building and the Cryostat Workshop. The base of the tokamak complex is being laid. Besides the construction that is taking place and will take place at the site, components from around the world have to navigate the complex route from Marseilles to the site. A test convoy replicating the dimensions and weights of the most exceptional ITER loads successfully traversed that route in 2013. We are pleased to report that the IAEA and ITER have finalized the agreement for ITER authors to publish papers in Nuclear Fusion . Nuclear Fusion is proud to continue its key role in providing the leading forum for the documentation of scientific progress and exchange of research results internationally toward fusion energy. Refereeing The Nuclear Fusion editorial office appreciates greatly the effort made by our referees to sustain the high quality of the journal. Since January 2005, we have been offering the most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in previous years. The following people have been selected: J.M. Canik, Oak Ridge National Laboratory, USA I.T. Chapman, Culham Centre for Fusion Energy, UK L.-G. Eriksson, Commission of the European Communities, Belgium T. Evans

  7. EDITORIAL: Editor's Introduction

    NASA Astrophysics Data System (ADS)

    Blackburn, D. A.

    1990-01-01

    Since its first issue in 1965 Metrologia has had just three editors, a history of tenure which suggests that those who hold the post find in it sufficient to interest, occupy, challenge and amuse them. I see no reason to doubt that this happy circumstance will continue and look forward to my own period as editor with the intention of retaining, insofar as I am able to interpret them, the best traditions the journal has established so far. As I take up my editorial duties I have become aware that surrounding Metrologia there is a small community of authors, reviewers and readers on whose support the success of the journal entirely depends. It is a community in which the roles change daily with some of its members engaged, even simultaneously, as reader, reviewer and author. I am well aware that the goodwill extended to me as I enter this community is in no small part due the efforts of the outgoing editor, Dr Ralph Hudson, whose easy, engaging and courteous, yet firm, relationship with authors and reviewers emerges clearly from editorial correspondence. I thank him for that he has done and wish him an active and happy retirement. A short foray into the records of Metrologia shows - in the first editorial - that four main kinds of article were originally envisaged: research articles likely to contribute to progress in fundamental scientific measurements, reports of experiments or techniques of particular importance or originality in the area of secondary measurement, articles concerning the decisions of the Comité International des Poids et Mesures, and review articles. No balance was specified but a priority was assigned to articles dealing with fundamental metrology. Of the four categories, the first two represent the core of Metrologia's activity and largely determine its reputation as a publication. For this reason, editorial implementation of the policy set by the CIPM is mainly exercised through the operation of a reviewing system which is intentionally strict

  8. GUEST EDITORS' INTRODUCTION: Guest Editors' introduction

    NASA Astrophysics Data System (ADS)

    Coulson, Geoff; de Meer, Jan B.

    1997-03-01

    . Their scheme is embedded in an experimental ATM network with the potential for guaranteed QoS. The system features QoS support mechanisms in both the network and the end systems. Of particular interest is reported experience with a dynamic QoS adaptation protocol implemented in the network and based on video scaling techniques and filtering. In summary, this special issue provides an up to date review of approaches to QoS management and their practical realization. Of course, no claim is made as to comprehensiveness, but the chosen papers do serve as a highly representative sample of current directions in QoS research. The editors are very much obliged to all authors, reviewers and publishers. Without their excellent work, and the contribution of their valuable time this special issue would not have been possible.

  9. Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Strassmeier, Klaus G.

    2009-01-01

    As of 2007, Astronomische Nachrichten -- Astronomical Notes has reached its all-time high regarding the ISI journal impact factor, with an impressive increase of 60% compared to 2005. We now rank at 1,461, as shown in the statistics below. This is solely due to the increased quality of the published articles: In 2006, Astronomische Nachrichten -- Astronomical Notes published 208 research papers and received 1,033 citations -- five citations per paper on average. In 2007, we have published 177 research papers with roughly the same number of citations. In co-operation with Wiley InterScience we have achieved an average online publication time of just 4.5 months. We hope that the year 2008 will be comparably prosperous. As in the past, publication in Astronomische Nachrichten -- Astronomical Notes continues to be free of charge. Also, all articles of the first issue of each volume can be downloaded free of charge, as can all articles labelled ``Editor's Choice'', which are additionally featured with a color image on the front cover.

  10. Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Strassmeier, Klaus G.

    2008-01-01

    As of 2006, Astronomische Nachrichten -- Astronomical Notes has reached its all-time high regarding the ISI journal impact factor, with an impressive increase of 60% compared to 2005. We now rank at position 1,399, as shown in the statistics below. This is solely due to the increased number and quality of published articles: In 2006, Astronomische Nachrichten -- Astronomical Notes published 208 research papers and received 1,033 citations -- five citations per paper on average. In 2007, we have published 177 research papers, and one may be curious to see how their factor will develop. In co-operation with Wiley InterScience we have achieved an average o nline publication time of just 4.5 months. As in the past, publication in Astronomische Nachrichten -- Astronomical Notes} continues to be free of charge. Also, all articles of the first issue of each volume can be downloaded free of charge, as can all articles labelled ``Editor's Choice'', which are additionally featured with a color image on the front cover.

  11. Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice.

    PubMed

    Grieco, Anthony; Rzeczkowska, Paulina; Alm, Christina; Palmert, Mark R

    2013-01-30

    Genome-wide association studies recently identified 32 loci that associate with the age at menarche (AAM) in humans. Because the locus most robustly associated with AAM is in/near LIN28B, the goal of this study was to investigate how the Lin28 pathway might modulate pubertal timing by examining expression of Lin28b, and its homologue, Lin28a, across the pubertal transition in female mice. Quantitative reverse-transcriptase PCR data indicate that, prior to the onset of puberty, expression of both Lin28b and Lin28a decreases in the ovary, while expression of only Lin28a decreases in the hypothalamus; the expression of Lin28a increases after the onset of puberty in the pituitary. Immunohistochemistry in ovarian tissue verified that Lin28a protein levels decreased in parallel with gene expression. Although these data do not demonstrate cause and effect, they do suggest that decreased expression of Lin28a/Lin28b may facilitate the transition into puberty, consistent with previous data showing that overexpression of Lin28a in transgenic mice leads to delayed puberty. In addition, although Lin28b and/or Lin28a expression significantly decreased prior to puberty, neither Let-7a nor Let-7g miRNA levels changed significantly, raising the possibility that some effects of Lin28b and Lin28a within the hypothalamic-pituitary-gonadal (HPG) axis may be Let-7 miRNA independent. Subsequent studies, such as tissue and age specific modulation of Lin28b and Lin28a expression, could determine whether the expression patterns observed are responsible for modulating the onset of puberty and delineate further the role of this pathway in the HPG axis.

  12. Novel LinA type 3 δ-hexachlorocyclohexane dehydrochlorinase.

    PubMed

    Shrivastava, Nidhi; Prokop, Zbynek; Kumar, Ashwani

    2015-11-01

    LinA is the first enzyme of the microbial degradation pathway of a chlorinated insecticide, hexachlorocyclohexane (HCH), and mediates the dehydrochlorination of α-, γ-, and δ-HCH. Its two variants, LinA type 1 and LinA type 2, which differ at 10 out of 156 amino acid residues, have been described. Their activities for the metabolism of different HCH isomers differ considerably but overall are high for γ-HCH, moderate for α-HCH, low for δ-HCH, and lacking for β-HCH. Here, we describe the characterization of a new variant of this enzyme, LinA type 3, whose gene was identified from the metagenome of an HCH-contaminated soil sample. Its deduced primary structure in the region spanning amino acid residues 1 to 147 of the protein exhibits 17 and 12 differences from LinA type 1 and LinA type 2, respectively. In addition, the residues GIHFAPS, present at the region spanning residues 148 to 154 in both LinA type 1 and LinA type 2, are deleted in LinA type 3.The activity of LinA type 3 for the metabolism of δ-HCH is several orders of magnitude higher than that of LinA type 1 or LinA type 2 and can be useful for improvement of the metabolism of δ-HCH.

  13. Novel LinA Type 3 δ-Hexachlorocyclohexane Dehydrochlorinase

    PubMed Central

    Shrivastava, Nidhi; Prokop, Zbynek

    2015-01-01

    LinA is the first enzyme of the microbial degradation pathway of a chlorinated insecticide, hexachlorocyclohexane (HCH), and mediates the dehydrochlorination of α-, γ-, and δ-HCH. Its two variants, LinA type 1 and LinA type 2, which differ at 10 out of 156 amino acid residues, have been described. Their activities for the metabolism of different HCH isomers differ considerably but overall are high for γ-HCH, moderate for α-HCH, low for δ-HCH, and lacking for β-HCH. Here, we describe the characterization of a new variant of this enzyme, LinA type 3, whose gene was identified from the metagenome of an HCH-contaminated soil sample. Its deduced primary structure in the region spanning amino acid residues 1 to 147 of the protein exhibits 17 and 12 differences from LinA type 1 and LinA type 2, respectively. In addition, the residues GIHFAPS, present at the region spanning residues 148 to 154 in both LinA type 1 and LinA type 2, are deleted in LinA type 3.The activity of LinA type 3 for the metabolism of δ-HCH is several orders of magnitude higher than that of LinA type 1 or LinA type 2 and can be useful for improvement of the metabolism of δ-HCH. PMID:26296732

  14. Guest Editor's introduction

    NASA Astrophysics Data System (ADS)

    1996-03-01

    pleasure to be Guest Editor and I look forward to future developments in this growing research area and expositions in Distributed Systems Engineering. Peter G Harrison Imperial College, London

  15. Message from the Editor

    NASA Astrophysics Data System (ADS)

    Stambaugh, Ronald D.

    2013-01-01

    reviewed five manuscripts in the period November 2011 to December 2012 and provided excellent advice to the authors. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in recent years. The following people have been selected: Marina Becoulet, CEA-Cadarache, France Jiaqui Dong, Southwestern Institute of Physics, China Emiliano Fable, Max-Planck-Institut für Plasmaphysik, Germany Ambrogio Fasoli, Ecole Polytechnique Federale de Lausanne, Switzerland Eric Fredrickson, Princeton Plasma Physics Laboratory, USA Manuel Garcia-Munoz, Max-Planck-Institut fuer Plasmaphysik, Germany William Heidbrink, California University, USA Katsumi Ida, National Inst. For Fusion Science, Japan Peter Stangeby, Toronto University, Canada James Strachan, Princeton Plasma Physics Laboratory, USA Victor Yavorskij, Ukraine National Academy of Sciences, Ukraine In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2012. Our thanks to them!

  16. New Editors for AGU Journals

    NASA Astrophysics Data System (ADS)

    Panning, Jeanette

    2014-10-01

    John Orcutt, the editor in chief of Earth and Space Science, has filled in his editorial board with Andrea Donnellan (University of Southern California), Jonathan H. Jiang (NASA Jet Propulsion Laboratory, California Institute of Technology), Benoît Pirenne (University of Victoria, BC, Canada), and Frank Vernon (University of California, San Diego).

  17. SIERRA Editor v. 1.2.1

    SciTech Connect

    Hoffman, Edward; Friedman-Hill, Ernest; Gibson, Marcus; Heinstein, Martin; & Whittford, Greg

    2010-03-24

    The SIERRA Editor is a syntax editor for text-based input decks for the SIERRA modeling and simulations codes. The SIERRA Editor provides color coded syntax, error checking, hyperlink navigation to referenced entities (e.g. functions and materials), and visual verification of mesh entity references (blocks, sidesets, and nodesets). The SIERRA Editor helps modeling and simulation analysts who use the SIERRA codes to produce syntactically correct input decks.

  18. New Editors, Editorial Advisory Board for Eos

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    2010-11-01

    Eos has two new editors and, with this issue, a revitalized Editorial Advisory Board. Christina M. S. Cohen, of the California Institute of Technology, is the new editor for space sciences. She succeeds Manuel Grande, who had served since 2006. Carol A. Stein, of the University of Illinois at Chicago, is the new editor for solid Earth. She succeeds John W. Geissman, who has been solid Earth editor since 2001; he will continue through the end of 2010.

  19. Line-Editor Computer Program

    NASA Technical Reports Server (NTRS)

    Scott, Peter J.

    1989-01-01

    ZED editing program for DEC VAX computer simple, powerful line editor for text, program source code, and nonbinary data. Excels in processing of text by use of procedure files. Also features versatile search qualifiers, global changes, conditionals, online help, hexadecimal mode, space compression, looping, logical combinations of search strings, journaling, visible control characters, and automatic detabbing. Users of Cambridge implementation devised such ZED procedures as chess games, calculators, and programs for evaluating pi. Written entirely in C.

  20. EDITORIAL: Message from the Editor Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2010-02-01

    November 2009 and provided particularly detailed advice to the authors. The other three have been very helpful in 'minority fields'. We have excluded our Board members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their Special Issues is also excluded from consideration. The following people have been selected: Tomonori Takizuka, JAEA-Naka Fusion Institute, Japan Rudolf Neu, Max-Planck-Institut für Plasmaphysik, Germany Sibylle Guenter, Max-Planck-Institut für Plasmaphysik, Germany Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States David R. Mikkelsen, Princeton Plasma Physics Laboratory, United States Peter C. de Vries, EURATOM/UKAEA Fusion Association, United Kingdom Yasuhiro Suzuki, National Institute for Fusion Science, Japan Jerzy Wolowski, Institute of Plasma Physics and Laser Microfusion, Poland Tetsuo Tanabe, Kyushu University, Japan Yasuyuki Yagi, National Institute of Advanced Industrial Science and Technology, Japan Congratulations and many, many thanks! The Guest Editors of special editions deserve a special mention for the excellent help that they have given us. They are: Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States, Special Issue on H-Mode Physics and Transport Barriers Yaroslav Kolesnichenko, Institute for Nuclear Research, Ukraine, Special Issue on Energetic Particles in Magnetic Confinement Systems Kimitaka Itoh, National Institute for Fusion Science, Japan and Howard R. Wilson, University of York, UK, Special Issue on Plasma Instabilities Bernhard Unterberg, Forschungszentrum Juelich, Germany, Special Issue on Stochastic Fusion Plasma In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2009. Our thanks to them! Authors The winner of the 2009 Nuclear Fusion

  1. Lin28 enhances tissue repair by reprogramming cellular metabolism

    PubMed Central

    Shyh-Chang, Ng; Zhu, Hao; de Soysa, T. Yvanka; Shinoda, Gen; Seligson, Marc T.; Tsanov, Kaloyan M.; Nguyen, Liem; Asara, John M.; Cantley, Lewis C.; Daley, George Q.

    2014-01-01

    SUMMARY Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue repair remains unexplained. Lin28a, a highly-conserved RNA binding protein expressed during embryogenesis, plays roles in development, pluripotency and metabolism. To determine if Lin28a might influence tissue repair in adults, we engineered the reactivation of Lin28a expression in several models of tissue injury. Lin28a reactivation improved hair regrowth by promoting anagen in hair follicles, and accelerated regrowth of cartilage, bone and mesenchyme after ear and digit injuries. Lin28a inhibits let-7 microRNA biogenesis; however let-7 repression was necessary but insufficient to enhance repair. Lin28a bound to and enhanced the translation of mRNAs for several metabolic enzymes, thereby increasing glycolysis and oxidative phosphorylation (OxPhos). Lin28a-mediated enhancement of tissue repair was negated by OxPhos inhibition, whereas a pharmacologically-induced increase in OxPhos enhanced repair. Thus, Lin28a enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics. PMID:24209617

  2. EDITORIAL: Message from the Editor Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2011-01-01

    As usual, being an even year, the 23rd IAEA Fusion Energy Conference took place at Daejeon, Korea. The event was notable not just for the quality of the presentations but also for the spectacular opening ceremony, in the presence of the Prime Minister, Kim Hwang-sik. The Prime Minister affirmed the importance of research into fusion energy research and pledged support for ITER. Such political visibility is good news, of course, but it brings with it the obligation to perform. Fortunately, good performance was much in evidence in the papers presented at the conference, of which a significant proportion contain 'ITER' in the title. Given this importance of ITER and the undertaking by the Nuclear Fusion journal to publish papers associated with Fusion Energy Conference presentations, the Nuclear Fusion Editorial Board has decided to adopt a simplified journal scope that encompasses technology papers more naturally. The scope is available from http://iopscience.iop.org/0029-5515/page/Journal%20information but is reproduced here for clarity: Nuclear Fusion publishes articles making significant advances to the field of controlled thermonuclear fusion. The journal scope includes: the production, heating and confinement of high temperature plasmas; the physical properties of such plasmas; the experimental or theoretical methods of exploring or explaining them; fusion reactor physics; reactor concepts; fusion technologies. The key to scope acceptability is now '....significant advances....' rather than any particular area of controlled thermonuclear fusion research. It is hoped that this will make scope decisions easier for the Nuclear Fusion office, the referees and the Editor.The Nuclear Fusion journal has continued to make an important contribution to the research programme and has maintained its position as the leading journal in the field. This is underlined by the fact that Nuclear Fusion has received an impact factor of 4.270, as listed in ISI's 2009 Science Citation

  3. Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

    ERIC Educational Resources Information Center

    Amare, Nicole; Manning, Alan

    2009-01-01

    Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

  4. The Lin28/let-7 axis regulates glucose metabolism.

    PubMed

    Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V; Shinoda, Gen; Shah, Samar P; Einhorn, William S; Takeuchi, Ayumu; Engreitz, Jesse M; Hagan, John P; Kharas, Michael G; Urbach, Achia; Thornton, James E; Triboulet, Robinson; Gregory, Richard I; Altshuler, David; Daley, George Q

    2011-09-30

    The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promote an insulin-sensitized state that resists high-fat-diet induced diabetes. Conversely, muscle-specific loss of Lin28a or overexpression of let-7 results in insulin resistance and impaired glucose tolerance. These phenomena occur, in part, through the let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. In addition, the mTOR inhibitor, rapamycin, abrogates Lin28a-mediated insulin sensitivity and enhanced glucose uptake. Moreover, let-7 targets are enriched for genes containing SNPs associated with type 2 diabetes and control of fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

  5. ESO Vacancy - Editor (EDG 604)

    NASA Astrophysics Data System (ADS)

    2002-09-01

    Assignment: Within the ESO Education and Public Relations Department team, your main tasks and responsibilities will comprise: • Development, update and maintenance of the comprehensive ESO Outreach website in its new look, including preparation of related material (texts, images, etc.) to be displayed; • Design, layout and production of the ESO quarterly journal “The Messenger” (e.g. image selection and processing, technical editing, etc.), in close collaboration with the Messenger editor; • Conception and production of promotional brochures, posters and other EPR products, in close collaboration with the Head of the Education and Public Relations Dept. of ESO Press Releases and various high-level publications, including the ESO Annual Report.

  6. On the low regularity of the Benney-Lin equation

    NASA Astrophysics Data System (ADS)

    Chen, Wengu; Li, Junfeng

    2008-03-01

    We consider the low regularity of the Benney-Lin equation ut+uux+uxxx+[beta](uxx+uxxxx)+[eta]uxxxxx=0. We established the global well posedness for the initial value problem of Benney-Lin equation in the Sobolev spaces for 0[greater-or-equal, slanted]s>-2, improving the well-posedness result of Biagioni and Linares [H.A. Biaginoi, F. Linares, On the Benney-Lin and Kawahara equation, J. Math. Anal. Appl. 211 (1997) 131-152]. For s<-2 we also prove some ill-posedness issues.

  7. Letter to Editor - "Reply to RP Heaney"

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A letter to the editor was submitted in reply to a letter written to the editor of the American Journal of Clinical Nutrition regarding a recent publication (Hunt, CD. and Johnson, LK. Calcium requirements: new estimations for men and women by cross-sectional statistical analyses of calcium balance...

  8. Good editorial practice: editors as educators.

    PubMed

    Marusić, M; Marusić, A

    2001-04-01

    There may be valuable research going on in the developing and financially less-privileged countries, but it usually does not reach international visibility, in spite of a large number of scientific journals in these countries. Such journals are not only invisible but, by perpetuating a vicious circle of inadequacy, may be directly damaging to the local science and research culture. We call for an international action to help journal editors in less privileged countries. International associations of editors may be leaders of these activities by defining, promoting, and perhaps controlling good editorial practice, as a main criterion for international recognition of a journal. However, the editors of small journals have the power and moral obligation to become a stronghold of quality and advancement in their scientific community. Their educational "tools" are editorial integrity and author-friendly policy. Editors can teach the authors study design, statistical analysis, precision, punctuality, research integrity, style and format of writing, and other aspects of scientific communication. The editors of "big", mainstream scientific journals can act as global educators, teaching and providing guidance to editors of small journals. The editors from developed countries as leaders, and editors from less advantageous environments as teachers are the key figures in shaping research communication in less privileged scientific communities.

  9. Linguistic Prescriptivism in Letters to the Editor

    ERIC Educational Resources Information Center

    Lukac, Morana

    2016-01-01

    The public's concern with the fate of the standard language has been well documented in the history of the complaint tradition. The print media have for centuries featured letters to the editor on questions of language use. This study examines a corpus of 258 language-related letters to the editor published in the English-speaking print media. By…

  10. A Synonym for Editor Must Be Leader.

    ERIC Educational Resources Information Center

    Konkle, Bruce E.

    2003-01-01

    Contends that in scholastic journalism, the editor might not be the best writer, designer, or photographer, but he or she must have a vision of what the final publication should be. Lists the following desirable traits of an editor: strong work ethic; motivation; organization; background knowledge; and responsibility. (PM)

  11. Technical Editor Looks at Technical Writing.

    ERIC Educational Resources Information Center

    Smith, Howard (Bud)

    1982-01-01

    The author explores problems in technical writing, the editor's role, and the author-editor relationship. He presents a list of basic writing rules to help the technical writer achieve success. These involve subject matter, deadlines, purpose, topic sentences, arrangement, clarity, idea development, examples, vocabulary, reading level, and…

  12. EDITORIAL: Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2009-01-01

    Plasmaphysik, Germany) V. Philipps (Forschungszentrum Juelich, Germany) S. Zweben (Princeton Plasma Physics Laboratory, USA) Y. Hirano (National Institute of Advanced Industrial Science and Technology, Japan) Y. Takase (Tokyo University, Japan) In addition there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2008. Our thanks to them! Authors The winner of the 2007 award was Clemente Angioni for the paper entitled `Density response to central electron heating: theoretical investigations and experimental observations in ASDEX Upgrade' (Nucl. Fusion 44 8277-845). The winner of the 2008 Nuclear Fusion award is Todd Evans et al for the paper `Suppression of large edge localized modes with edge resonant magnetic fields in high confinement DIII-D plasmas' (Nucl. Fusion 45 595-607). The awards were presented by the IAEA Deputy Director General, Werner Burkart, and the Chairman of the Board of Editors, Mitsuru Kikuchi, on 16 October 2008 at the 22nd IAEA Fusion Energy Conference in Geneva, Switzerland. Given the topicality of these papers for the ITER design, it is a matter of pride to the journal that the work should be published in Nuclear Fusion. Reviews Like many who have worked for a long time in the field, I still make use of Nuclear Fusion Reviews that go back 20 or 30 years. It is particularly useful, therefore, that the Board of Editors has been working to re-activate the review programme. The first fruits will appear in this issue, in the form of `A review of zonal flow experiments', by Akihide Fujisawa. The special procedures for Reviews should be noted: most specifically that they should normally be commissioned by the Board of Editors. However, not only is the Board of Editors working on a programme but I am sure that they would be pleased to consider suggestions for review subjects. Letters The reputation of Nuclear

  13. In vitro expansion of Lin{sup +} and Lin{sup −} mononuclear cells from human peripheral blood

    SciTech Connect

    Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul; Rohaya, M. A. W.

    2013-11-27

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin{sup −}) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin{sup +}) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin{sup −} cell population. The ability of Lin{sup +} and Lin{sup −} to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin{sup +} and Lin{sup −} were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin{sup +} mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin{sup −} stem cells were not able to survive in proliferation medium however

  14. Enantioselective transformation of alpha-hexachlorocyclohexane by the dehydrochlorinases LinA1 and LinA2 from the soil bacterium Sphingomonas paucimobilis B90A.

    PubMed

    Suar, Mrutyunjay; Hauser, Andrea; Poiger, Thomas; Buser, Hans-Rudolf; Müller, Markus D; Dogra, Charu; Raina, Vishakha; Holliger, Christof; van der Meer, Jan Roelof; Lal, Rup; Kohler, Hans-Peter E

    2005-12-01

    Sphingomonas paucimobilis B90A contains two variants, LinA1 and LinA2, of a dehydrochlorinase that catalyzes the first and second steps in the metabolism of hexachlorocyclohexanes (R. Kumari, S. Subudhi, M. Suar, G. Dhingra, V. Raina, C. Dogra, S. Lal, J. R. van der Meer, C. Holliger, and R. Lal, Appl. Environ. Microbiol. 68:6021-6028, 2002). On the amino acid level, LinA1 and LinA2 were 88% identical to each other, and LinA2 was 100% identical to LinA of S. paucimobilis UT26. Incubation of chiral alpha-hexachlorocyclohexane (alpha-HCH) with Escherichia coli BL21 expressing functional LinA1 and LinA2 S-glutathione transferase fusion proteins showed that LinA1 preferentially converted the (+) enantiomer, whereas LinA2 preferred the (-) enantiomer. Concurrent formation and subsequent dissipation of beta-pentachlorocyclohexene enantiomers was also observed in these experiments, indicating that there was enantioselective formation and/or dissipation of these enantiomers. LinA1 preferentially formed (3S,4S,5R,6R)-1,3,4,5,6-pentachlorocyclohexene, and LinA2 preferentially formed (3R,4R,5S,6S)-1,3,4,5,6-pentachlorocyclohexene. Because enantioselectivity was not observed in incubations with whole cells of S. paucimobilis B90A, we concluded that LinA1 and LinA2 are equally active in this organism. The enantioselective transformation of chiral alpha-HCH by LinA1 and LinA2 provides the first evidence of the molecular basis for the changed enantiomer composition of alpha-HCH in many natural environments. Enantioselective degradation may be one of the key processes determining enantiomer composition, especially when strains that contain only one of the linA genes, such as S. paucimobilis UT26, prevail.

  15. LIN28A Expression Reduces Sickling of Cultured Human Erythrocytes

    PubMed Central

    de Vasconcellos, Jaira F.; Fasano, Ross M.; Lee, Y. Terry; Kaushal, Megha; Byrnes, Colleen; Meier, Emily R.; Anderson, Molly; Rabel, Antoinette; Braylan, Raul; Stroncek, David F.; Miller, Jeffery L.

    2014-01-01

    Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with sickle cell disease (SCD) and the beta-thalassemias. It was recently reported that increased expression of LIN28 proteins or decreased expression of its target let-7 miRNAs enhances HbF levels in cultured primary human erythroblasts from adult healthy donors. Here LIN28A effects were studied further using erythrocytes cultured from peripheral blood progenitor cells of pediatric subjects with SCD. Transgenic expression of LIN28A was accomplished by lentiviral transduction in CD34(+) sickle cells cultivated ex vivo in serum-free medium. LIN28A over-expression (LIN28A-OE) increased HbF, reduced beta (sickle)-globin, and strongly suppressed all members of the let-7 family of miRNAs. LIN28A-OE did not affect erythroblast differentiation or prevent enucleation, but it significantly reduced or ameliorated the sickling morphologies of the enucleated erythrocytes. PMID:25188417

  16. EDITORIAL: Letter from the Editor Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Pashinin, Pavel P.

    2013-01-01

    Dear readers, contributors, and members of the world laser physics community. It is a great honour for us to introduce to you our new publishing partner, IOP Publishing, a subsidiary of the Institute of Physics, United Kingdom. IOP Publishing is a world renowned authority in producing journals, magazines, websites and services that enable researchers and research organizations to present their work to a world-wide audience. Laser Physics, the first English-language scientific journal in Russia, was founded in 1990 on the initiative of Alexander M Prokhorov, a pioneer and leader in laser physics research. Professor Prokhorov served as the first Editor-in-Chief of the journal until 2002. We are proud that it is our 23rd year of publishing Laser Physics and our 10th year of publishing Laser Physics Letters. We would like to honour the memory of our friend, late Professor Igor Yevseyev, whose enthusiasm and unwavering dedication to our journals contributed most significantly to their success. It was initially his idea in 2011 to approach IOP with a partnership proposal. We deeply regret that he is no longer with us as we enter this productive alliance. Now, in partnership with IOP, we are turning a new page in providing world-wide access to the cutting-edge research results in our journals, serving our well established global audience. We see new horizons opening for our journals for years to come and hope that our readers share our enthusiasm and aspirations. Please accept our best wishes for all your new scientific endeavors in the exciting field of laser physics.

  17. Richard Gilbert, Reporter and Assistant City Editor.

    ERIC Educational Resources Information Center

    Bender, Larry

    1988-01-01

    Looks at the experiences of Richard Gilbert, reporter and assistant editor for "The Herald Telephone," a daily newspaper in Bloomington, Indiana, and discusses Gilbert's suggested guidelines for high school journalism advisers. (MS)

  18. Fax etiquette for nurse authors and editors.

    PubMed

    Johnson, S H

    1997-01-01

    Is the facsimile (fax) machine really as great as it seems? Yes, but there is a potential for its misuse. Like all equipment, the fax machine is a tool that needs to be used wisely. This article describes the Do's and Don'ts of using the fax machine to communicate between authors and editors. Tips in this article will help authors and editors to correspond smoothly by fax and use new fax equipment options.

  19. Report of the editors, 2014.

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2015-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) Objectives and attainments in 2014, (b) Editorial activity, 2014, and (c) 2013 impact factor. In 2014 we achieved the 5 planned objectives. We have published the 9 programmed issues and 103% of the planned papers according to the usual fixed sections. We emphasize the publication of 29 editorials, 21 of which are signed by prestigious foreign authors. From the first January to the 30th September 2014 we received 421 manuscripts (46.8 manuscripts per month), a slight lower figure to that obtained in 2013 (50.9 manuscripts per month). The acceptance rate of the 404 manuscripts whose editorial process has been concluded was 32.3% (originals, 22.4%). We asked for 315 revisions to 240 reviewers and we received 53.3% revisions in less than two weeks (10.4 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 18,3 (less than half than in 2009). For «originals» this figure has dropped from 56,6 days in 2009 to 26.6 days in 2014. The mean time elapsed from manuscript reception to its on-line publication was 103 days. In 2014 the collaboration with the working groups from the Internal Medicine Spanish Foundation (FEMI) has reported 11 published manuscripts. In July 2014 we were informed that the Journal Citation Reports gave Rev Clin Esp an Impact Factor of 1,314 (year 2013). This Impact Factor without self-citations would have been 0.705 (in 2009 the global impact factor was 0,584). With the Editorial Committee farewell we welcome the new editorial team and we sincerely thank the SEMI Steering Committee, our colleagues, journal officers, reviewers, readers and authors that since 2009 have trusted on our editorial work.

  20. Stepwise enhancement of catalytic performance of haloalkane dehalogenase LinB towards β-hexachlorocyclohexane

    PubMed Central

    2014-01-01

    Two haloalkane dehalogenases, LinBUT and LinBMI, each with 296 amino acid residues, exhibit only seven amino acid residue differences between them, but LinBMI’s catalytic performance towards β-hexachlorocyclohexane (β-HCH) is considerably higher than LinBUT’s. To elucidate the molecular basis governing this difference, intermediate mutants between LinBUT and LinBMI were constructed and kinetically characterized. The activities of LinBUT-based mutants gradually increased by cumulative mutations into LinBUT, and the effects of the individual amino acid substitutions depended on combination with other mutations. These results indicated that LinBUT’s β-HCH degradation activity can be enhanced in a stepwise manner by the accumulation of point mutations. PMID:25401073

  1. EDITORIAL: Message from the Editor Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2012-01-01

    Board Members, Guest Editors of special editions and those referees who were already listed in the last years. The following people have been selected: Marina Becoulet, CEA Cadarache, France Russell Doerner, University of California - San Diego, USA Emiliano Fable, Max-Planck-Institut fuer Plasmaphysik, Germany Akihide Fujisawa, Kyushi University, Japan Gerardo Giruzzi, CEA Cadarache, France Grigory Kagan, LANL, USA Morten Lennholm, CCFE, UK Akinobu Matsuyama, NIFS, Japan Peter Stangeby, University of Toronto, Canada Leonid Zakharov, PPPL, USA In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2011. Our thanks to them! Authors The winner of the 2011 Nuclear Fusion Award is H. Urano, for the paper 'Dimensionless parameter dependence of H-mode pedestal width using hydrogen and deuterium plasmas in JT-60U' (Nucl. Fusion 48 045008). The award was presented at the Plasma Conference 2011 (Joint meeting of 28th JSPF Annual Meeting, The 29th Symposium on Plasma Processing, and Division of Plasma Physics, 2011 Autumn Meeting of The Physical Society of Japan). This is the sixth year that the International Atomic Energy Agency (IAEA) has awarded an annual prize to honour exceptional work published in Nuclear Fusion. IOP Publishing has generously made a contribution of $2500 to the award. The Nuclear Fusion Electronic Archive The journal's electronic archive has been online since the beginning of the year. The archive has been a roaring success and has contributed to the nearly 300 000 downloads of journal papers in 2011. The archive can be accessed via http://iopscience.iop.org/0029-5515/page/Archive. It has direct links to 16 landmark papers, from authors such as Artsimovich and Mercier. The Nuclear Fusion office and IOP Publishing Just as the journal depends on the authors and referees, so its success is also

  2. [Report of the editors, 2013].

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2014-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 20,3 (half than in 2009). For «originals» this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day

  3. [Report of the editors, 2013].

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2014-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 20,3 (half than in 2009). For «originals» this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day

  4. Report of the editors, 2014.

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2015-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) Objectives and attainments in 2014, (b) Editorial activity, 2014, and (c) 2013 impact factor. In 2014 we achieved the 5 planned objectives. We have published the 9 programmed issues and 103% of the planned papers according to the usual fixed sections. We emphasize the publication of 29 editorials, 21 of which are signed by prestigious foreign authors. From the first January to the 30th September 2014 we received 421 manuscripts (46.8 manuscripts per month), a slight lower figure to that obtained in 2013 (50.9 manuscripts per month). The acceptance rate of the 404 manuscripts whose editorial process has been concluded was 32.3% (originals, 22.4%). We asked for 315 revisions to 240 reviewers and we received 53.3% revisions in less than two weeks (10.4 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 18,3 (less than half than in 2009). For «originals» this figure has dropped from 56,6 days in 2009 to 26.6 days in 2014. The mean time elapsed from manuscript reception to its on-line publication was 103 days. In 2014 the collaboration with the working groups from the Internal Medicine Spanish Foundation (FEMI) has reported 11 published manuscripts. In July 2014 we were informed that the Journal Citation Reports gave Rev Clin Esp an Impact Factor of 1,314 (year 2013). This Impact Factor without self-citations would have been 0.705 (in 2009 the global impact factor was 0,584). With the Editorial Committee farewell we welcome the new editorial team and we sincerely thank the SEMI Steering Committee, our colleagues, journal officers, reviewers, readers and authors that since 2009 have trusted on our editorial work. PMID:25441406

  5. EDITORIAL: Letter from the Editor Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2011-01-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2010, and special thanks go to those of you who have kindly reviewed articles for the journal. I would also like to take this opportunity to update you on some of the developments on the journal and look ahead to 2011. As many of you are no doubt aware, our impact factor (a measure of the average number of times recent papers are referred to by others) is currently 1.317. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization (Thomson ISI) agreeing with my own assessment. Measurement Science and Technology is a journal with a broad scope covering new measurement techniques in all fields of science and engineering. I therefore find it particularly enjoyable to read summaries of recent research in our strong topical review programme as these cover many varied topics of interest. In 2010 several interesting articles by international leaders in their field were published, for example: Single-photon generation and detection, by G S Buller and R J Collins of Heriot-Watt University [1]. Fluorescence lifetime imaging microscopy in life sciences, by Jan Willem Borst and Antonie J W G Visser, from the Microspectroscopy Centre of Wageningen University [2]. Biological and chemical sensors for cancer diagnosis, by Elfriede Simon of Siemens AG [3]. I hope that these articles, and the others published in 2010 and now in 2011, will provide a useful overview for our readers, and be helpful to new researchers. When speaking to young researchers I am particularly aware that having their articles published in a timely fashion is important, and I am pleased that our publication times are highly competitive, with most authors receiving a

  6. AGU Publications Volunteers Feted At Elegant Editors' Evening

    NASA Astrophysics Data System (ADS)

    Panning, Jeanette

    2013-01-01

    The 2012 Fall Meeting Editors' Evening, held at the City Club of San Francisco, was hosted by the Publications Committee and is the premier social event for editors and associate editors attending the Fall Meeting. The evening commenced with a welcome from Carol Finn, incoming AGU president, in which she expressed her thanks to the editors and associate editors for volunteering their time to benefit AGU.

  7. [The Chilean Association of Biomedical Journal Editors].

    PubMed

    Reyes, H

    2001-01-01

    On September 29th, 2000, The Chilean Association of Biomedical Journal Editors was founded, sponsored by the "Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)" (the Governmental Agency promoting and funding scientific research and technological development in Chile) and the "Sociedad Médica de Santiago" (Chilean Society of Internal Medicine). The Association adopted the goals of the World Association of Medical Editors (WAME) and therefore it will foster "cooperation and communication among Editors of Chilean biomedical journals; to improve editorial standards, to promote professionalism in medical editing through education, self-criticism and self-regulation; and to encourage research on the principles and practice of medical editing". Twenty nine journals covering a closely similar number of different biomedical sciences, medical specialties, veterinary, dentistry and nursing, became Founding Members of the Association. A Governing Board was elected: President: Humberto Reyes, M.D. (Editor, Revista Médica de Chile); Vice-President: Mariano del Sol, M.D. (Editor, Revista Chilena de Anatomía); Secretary: Anna María Prat (CONICYT); Councilors: Manuel Krauskopff, Ph.D. (Editor, Biological Research) and Maritza Rahal, M.D. (Editor, Revista de Otorrinolaringología y Cirugía de Cabeza y Cuello). The Association will organize a Symposium on Biomedical Journal Editing and will spread information stimulating Chilean biomedical journals to become indexed in international databases and in SciELO-Chile, the main Chilean scientific website (www.scielo.cl).

  8. EDITORIAL: Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2008-01-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2007, and special thanks go to those of you who have kindly reviewed articles for the journal this year. I would also like to take this opportunity to update you on some of the developments on the journal. As many of you are no doubt aware, our latest impact factor (a measure of the average number of times recent papers are referred to by others) has risen to 1.228. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization agreeing with my own assessment. The popularity of the journal amongst authors and readers has prompted us to introduce a new subject classification for articles, to make it easier for readers to find articles of interest. The eight subject categories are: Measurement theory and practical developments (e.g. precision measurements, metrology, new measurement principles, signal processing techniques, theory of measurement, calibration); Sensors and sensing systems (based on physical, chemical or biological principles; micro- and nano-scale systems; sensors for physical, chemical and biological quantities); Optical and laser based techniques (e.g. fibre optics, interferometry, etc); Fluid mechanics measurements (e.g. fluid flow, velocimetry, particle sizing, etc); Imaging techniques (e.g. tomography, microscopy, holography, THz, etc); Spectroscopy (e.g. optical, acoustic, dielectric, MS, NMR, ESR, IR, UV-VIS, fluorescence, PCS, x-ray, etc); New and improved techniques for materials evaluation (e.g. non-destructive testing and evaluation, structural measurements); Novel instrumentation. We kindly ask you to assign your paper to a category when you send it to the journal. In order to maintain our rapid

  9. EDITORIAL: Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2008-01-01

    To begin, I would like to wish our readers, authors, referees and Board of Editors a successful and happy 2008 and thank them for their contributions to Nuclear Fusion in 2007. I took over the editorship of Nuclear Fusion in January, and the year has been one in which the community as a whole has been busier than ever with a variety of duties associated with the ITER project. It was with pride that we published the Progress in the ITER Physics Basis in the June issue of the journal (stacks.iop.org/NF/47/i=6). The task undertaken by the coordinators, authors and referees was a daunting one but one which led to an outstandingly successful issue. The response from readers has been phenomenal and there were in the region of 10 000 downloads of papers in the first month following publication. Looking to 2008 and beyond, the journal will endeavour to continue to support the work of the fusion community. Refereeing As we have done since January 2005, we would like to thank our top ten most loyal referees who have helped the journal with its double-referee peer-review procedure in the past year. At the Nuclear Fusion Editorial Office we are fully aware of the load we put on the shoulders of our referees. At the end of 2004 the Editorial Board decided that a gesture of gratitude should be made to our most loyal referees. We offer them a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. To select the top referees we have adopted the criterion that a researcher should have acted as a referee or adjudicator for at least three different manuscripts during the period from summer 2006 to the end of 2007. We have excluded our Board members and those referees who were already listed in the top ten in the last two years. According to our records the following people met this criterion. Congratulations and many, many thanks! H.L. Berk (Texas University, USA) J.S. DeGrassie (GAT, USA) C. Deutsch (Paris University, France) N. Hayashi (JAEA

  10. EDITORIAL: Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2009-01-01

    Marella de Angelis and her colleagues on precision gravimetry using atomic sensors and from Dr Peter Becker on determination of the Avogadro constant via enriched silicon-28. I recommend setting up a free e-mail alert so that you can read them as soon as they are published! As many of you are already aware, our impact factor (a measure of the average number of times recent papers are referred to by others) has risen again to 1.297. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization (Thomson ISI) agreeing with my own assessment. Of course the publication of high quality articles in the journal is dependent both on you the authors who trust us with the publication of your best work and on our referees and Editorial Board Members who we depend on to maintain the high standards you have grown to expect. I must also thank our referees for their rapid response when asked to review papers for Measurement Science and Technology. On average, authors receive a decision on their article in 45 days. Therefore I would like to end this message by saying thank you again to all those who have contributed to our success in the past year, and wish you all the best for a successful 2009!

  11. LIN28B suppresses microRNA let-7b expression to promote CD44+/LIN28B+ human pancreatic cancer stem cell proliferation and invasion

    PubMed Central

    Shao, Yebo; Zhang, Lei; Cui, Lei; Lou, Wenhui; Wang, Dansong; Lu, Weiqi; Jin, Dayong; Liu, Te

    2015-01-01

    Although the highly proliferative, migratory, and multi-drug resistant phenotype of human pancreatic cancer stem cells (PCSCs) is well characterized, knowledge of their biological mechanisms is limited. We used CD44 and LIN28B as markers to screen, isolate, and enrich CSCs from human primary pancreatic cancer. Using flow cytometry, we identified a human primary pancreatic cancer cell (PCC) subpopulation expressing high levels of both CD44 and LIN28B. CD44+/LIN28B+ PCSCs expressed high levels of stemness marker genes and possessed higher migratory and invasive ability than CD44-/LIN28B- PCCs. CD44+/LIN28B+ PCSCs were more resistant to growth inhibition induced by the chemotherapeutic drugs cisplatin and gemcitabine hydrochloride, and readily established tumors in vivo in a relatively short time. Moreover, microarray analysis revealed significant differences between the cDNA expression patterns of CD44+/LIN28B+ PCSCs and CD44-/LIN28B- PCCs. Following siRNA interference of endogenous LIN28B gene expression in CD44+/LIN28B+ PCSCs, not only was their proliferation decreased, there was also cell cycle arrest due to suppression of cyclin D1 expression following the stimulation of miRNA let-7b expression. In conclusion, CD44+/LIN28B+ cells, which possess CSC characteristics, can be reliably sorted from human primary PCCs and represent a valuable model for studying cancer cell physiology and multi-drug resistance. PMID:26609473

  12. EDITORIAL: Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2006-12-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2006, and special thanks go to those of you who have kindly reviewed articles for the journal this year. I would also like to take this opportunity to update you on some of the developments on the journal this year. As many of you are no doubt aware our impact factor (a measure of the average number of times recent papers are referred to by others) has remained above 1 for the second year in a row. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization agreeing with my own assessment. This year we have welcomed several new faces to our Editorial Board and International Advisory Board. We are delighted to welcome Professor Hirofumi Yamada of the University of Kyoto as a representative from Japan. From China we have been joined by Professor Xuzong Chen of Peking University and Professor Zhiyi Wei of Chinese Academy of Sciences, Beijing. Professor Ivan Marusic from University of Minnesota and Dr Paul Williams of the National Institute of Standards and Technology in Boulder have joined as North American representatives. As usual you will be able to submit your articles through them or direct to the Editorial Office in Bristol, UK. As part of our ongoing initiative to give our authors' work the highest visibility, all articles are freely available online for 30 days from the date of publication, allowing all researchers to read and view the latest research as soon as it is published, and this year there have been many interesting articles to read! As regular readers are aware, Measurement Science and Technology publishes special issues and features, which highlight an area of current interest. This year's topics included

  13. The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

    PubMed Central

    Huang, L S; Tzou, P; Sternberg, P W

    1994-01-01

    During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval epidermal fates. Genes necessary for this induction include the lin-3 growth factor, the let-23 receptor tyrosine kinase, and let-60 ras. lin-15 is a negative regulator of this inductive pathway. In lin-15 mutant animals, all six VPCs adopt vulval fates, even in the absence of inductive signal. Previous genetic studies suggested that lin-15 is a complex locus with two independently mutable activities, A and B. We have cloned the lin-15 locus by germline transformation and find that it encodes two nonoverlapping transcripts that are transcribed in the same direction. The downstream transcript encodes the lin-15A function; the upstream transcript encodes the lin-15B function. The predicted lin-15A and lin-15B proteins are novel and hydrophilic. We have identified a molecular null allele of lin-15 and have used it to analyze the role of lin-15 in the signaling pathway. We find that lin-15 acts upstream of let-23 and in parallel to the inductive signal. Images PMID:8054684

  14. Open Simulation Laboratories [Guest editors' introduction

    SciTech Connect

    Alexander, Francis J.; Meneveau, Charles

    2015-09-01

    The introduction for the special issue on open simulation laboratories, the guest editors describe how OSLs will become more common as their potential is better understood and they begin providing access to valuable datasets to much larger segments of the scientific community. Moreover, new analysis tools and ways to do science will inevitably develop as a result.

  15. A Visual Editor in Java for View

    NASA Technical Reports Server (NTRS)

    Stansifer, Ryan

    2000-01-01

    In this project we continued the development of a visual editor in the Java programming language to create screens on which to display real-time data. The data comes from the numerous systems monitoring the operation of the space shuttle while on the ground and in space, and from the many tests of subsystems. The data can be displayed on any computer platform running a Java-enabled World Wide Web (WWW) browser and connected to the Internet. Previously a special-purpose program bad been written to display data on emulations of character-based display screens used for many years at NASA. The goal now is to display bit-mapped screens created by a visual editor. We report here on the visual editor that creates the display screens. This project continues the work we bad done previously. Previously we had followed the design of the 'beanbox,' a prototype visual editor created by Sun Microsystems. We abandoned this approach and implemented a prototype using a more direct approach. In addition, our prototype is based on newly released Java 2 graphical user interface (GUI) libraries. The result has been a visually more appealing appearance and a more robust application.

  16. Are Editors Out of the Tenure Process?

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    University presses have complained for years that tenure committees unfairly expect their editors to be arbiters of what counts as tenure-worthy work. At the same time, the presses have been caught in a business-side squeeze between dwindling sales (and shrinking subsidies) and the ever-greater pressure on scholars to publish. In this article, the…

  17. Performance of a prototype atomic clock based on lin parallel lin coherent population trapping resonances in Rb atomic vapor

    SciTech Connect

    Mikhailov, Eugeniy E.; Horrom, Travis; Belcher, Nathan; Novikova, Irina

    2010-03-15

    We report on the performance of the first table-top prototype atomic clock based on coherent population trapping (CPT) resonances with parallel linearly polarized optical fields (lin parallel lin configuration). Our apparatus uses a vertical-cavity surface-emitting laser (VCSEL) tuned to the D{sub 1} line of {sup 87}Rb with the current modulation at the {sup 87}Rb hyperfine frequency. We demonstrate cancellation of the first-order light shift by the proper choice of rf modulation power and further improve our prototype clock stability by optimizing the parameters of the microwave lock loop. Operating in these optimal conditions, we measured a short-term fractional frequency stability (Allan deviation) 2x10{sup -11}{tau}{sup -1/2} for observation times 1 s{<=}{tau}{<=}20 s. This value is limited by large VCSEL phase noise and environmental temperature fluctuation. Further improvements in frequency stability should be possible with an apparatus designed as a dedicated lin parallel lin CPT resonance clock with environmental impacts minimized.

  18. OPM Scheme Editor 2: A graphical editor for specifying object-protocol structures

    SciTech Connect

    Chen, I-Min A.; Markowitz, V.M.; Pang, F.; Ben-Shachar, O.

    1993-07-01

    This document describes an X-window based Schema Editor for the Object-Protocol Model (OPM). OPM is a data model that supports the specification of complex object and protocol classes. objects and protocols are qualified in OPM by attributes that are defined over (associated with) value classes. Connections of object and protocol classes are expressed in OPM via attributes. OPM supports the specification (expansion) of protocols in terms of alternative and sequences of component (sub) protocols. The OPM Schema Editor allows specifying, displaying, modifying, and browsing through OPM schemas. The OPM Schema Editor generates an output file that can be used as input to an OPM schema translation tool that maps OPM schemas into definitions for relational database management systems. The OPM Schema Editor was implemented using C++ and the X11 based Motif toolkit, on Sun SPARCstation under Sun Unix OS 4.1. This document consists of the following parts: (1) A tutorial consisting of seven introductory lessons for the OPM Schema Editor. (2) A reference manual describing all the windows and functions of the OPM Schema Editor. (3) An appendix with an overview of OPM.

  19. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-04-01

    From the Board of Editors: on Plagiarism

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur

  20. Editor and Student Views on the Censorship Game.

    ERIC Educational Resources Information Center

    Raburn, Josephine

    Out of 200 newspaper editors randomly selected from a directory, 64 responded to a questionnaire eliciting their opinions on the subject materials most often censored by groups in the United States. The editors' responses were compared to those of 121 freshmen at Cameron University (Oklahoma). A majority of the editors supported the First…

  1. Editors' Attitudes toward Functions of the Community Press.

    ERIC Educational Resources Information Center

    Flocke, Elizabeth Lynne

    A study focused on isolating the differences in perceptions community newspaper editors have about the functions of their newspapers, and determining how those attitudes affect the editors' definition of news and, ultimately, the content of the newspapers. The study hypothesized (1) that the perceptions community newspaper editors have toward the…

  2. A Dynamic Attitude Measurement System Based on LINS

    PubMed Central

    Li, Hanzhou; Pan, Quan; Wang, Xiaoxu; Zhang, Juanni; Li, Jiang; Jiang, Xiangjun

    2014-01-01

    A dynamic attitude measurement system (DAMS) is developed based on a laser inertial navigation system (LINS). Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR) filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG). The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ) and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min. PMID:25177802

  3. A dynamic attitude measurement system based on LINS.

    PubMed

    Li, Hanzhou; Pan, Quan; Wang, Xiaoxu; Zhang, Juanni; Li, Jiang; Jiang, Xiangjun

    2014-01-01

    A dynamic attitude measurement system (DAMS) is developed based on a laser inertial navigation system (LINS). Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR) filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG). The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ) and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min. PMID:25177802

  4. Evolutionary theory in letters to the editor.

    PubMed

    Silva, Eric Orion; Lowe, Clayton Cory

    2015-05-01

    This research note presents the results of a content analysis of 234 letters to the editors that discuss evolutionary theory and were published in American newspapers. We find that letters to the editor both support and hinder the cause of teaching evolutionary theory in American secondary schools. On the one hand, anti-evolutionary theory messages are marginalized in the letters section. This marginalization signals a low level of legitimacy for creationism. It might also contribute to the sense of tension that sustains creationist identities. On the other hand, relatively few letters explicitly note the fact that scientists or the scientific community accept evolution. Interestingly, the obscuration of the scientific community's support for evolutionary theory occurs both in letters supporting and opposing evolutionary theory.

  5. Evolutionary theory in letters to the editor.

    PubMed

    Silva, Eric Orion; Lowe, Clayton Cory

    2015-05-01

    This research note presents the results of a content analysis of 234 letters to the editors that discuss evolutionary theory and were published in American newspapers. We find that letters to the editor both support and hinder the cause of teaching evolutionary theory in American secondary schools. On the one hand, anti-evolutionary theory messages are marginalized in the letters section. This marginalization signals a low level of legitimacy for creationism. It might also contribute to the sense of tension that sustains creationist identities. On the other hand, relatively few letters explicitly note the fact that scientists or the scientific community accept evolution. Interestingly, the obscuration of the scientific community's support for evolutionary theory occurs both in letters supporting and opposing evolutionary theory. PMID:25540333

  6. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-05-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially

  7. Meet the Editors: Water Resources Research

    NASA Astrophysics Data System (ADS)

    Kumar, Mohi

    2006-02-01

    On 1 January 2005, a five-member team assumed editorial responsibility for Water Resources Research (WRR). A year later the team of Brian Berkowitz, Amilcare Porporato, Thomas Torgersen, Scott Tyler, and Editor-in-Chief Marc Parlange are pleased with the successes of several changes to the journal. ``WRR is the international stage where new and emerging ideas are discussed and where the directions for scientific research in all aspects of hydrology are charted,'' explained Porporato. ``This is the reason why we have worked hard with our associate editors to attract `opinion papers,' `inspired reviews,' and, more recently, `rapid communications.''' The aim of these new paper types is to encourage discussion of water resource issues relevant to society and to quickly present new results that advance theoretical, mathematical, technological, and experimental observations, Porporato said.

  8. New Editors Appointed for Sections of Journal of Geophysical Research

    NASA Astrophysics Data System (ADS)

    2009-04-01

    New editors have been appointed for the Atmospheres, Biogeosciences, and Oceans sections of the Journal of Geophysical Research (JGR). Joost de Gouw (NOAA, Boulder, Colo.) and Renyi Zhang (Texas A&M, College Station) are filling the vacancies of retiring Atmospheres section editors John Austin and Jose Fuentes. De Gouw and Zhang join the continuing editors Steven Ghan and Yinon Rudich. Sara Pryor (Indiana University, Bloomington) is joining the Atmospheres section editorial board as an associate editor now; she will transition to editor in January 2010.

  9. Ethical responsibilities of editors, reviewers, and authors.

    PubMed

    Cowell, H R

    2000-09-01

    Scientific misconduct, which is neither new nor unique, is prevalent in the medical literature. Although fabrication of data obviously is unethical, and although ethical rules of conduct for certain aspects of medical studies, such as informed consent, are theoretically accepted worldwide, numerous authors do not adhere to ethical rules of conduct. Ethically, the editor is responsible, as a gatekeeper, for ensuring that material to be published is accurate and valid. Thus, the editor's main responsibility is to the reader. Nonetheless, the editor also must serve the author by selecting unbiased reviewers and by providing the assurance that material will be selected for publication based solely on the scientific quality of the material. Peer reviewers are obligated to maintain a posture of confidentiality throughout the review process. Authors are responsible for adequate planning before undertaking a study, and for safeguarding patients' rights during the study. The author must read all cited references completely, strive for accuracy, and be certain that the material reported is valid, because it will be used in the treatment of patients. Hopefully, awareness of the ethical problems related to medical writing will provide a clearer understanding of the ethical aspects of medical writing.

  10. Lin-28 promotes symmetric stem cell division and drives adaptive growth in the adult Drosophila intestine.

    PubMed

    Chen, Ching-Huan; Luhur, Arthur; Sokol, Nicholas

    2015-10-15

    Stem cells switch between asymmetric and symmetric division to expand in number as tissues grow during development and in response to environmental changes. The stem cell intrinsic proteins controlling this switch are largely unknown, but one candidate is the Lin-28 pluripotency factor. A conserved RNA-binding protein that is downregulated in most animals as they develop from embryos to adults, Lin-28 persists in populations of adult stem cells. Its function in these cells has not been previously characterized. Here, we report that Lin-28 is highly enriched in adult intestinal stem cells in the Drosophila intestine. lin-28 null mutants are homozygous viable but display defects in this population of cells, which fail to undergo a characteristic food-triggered expansion in number and have reduced rates of symmetric division as well as reduced insulin signaling. Immunoprecipitation of Lin-28-bound mRNAs identified Insulin-like Receptor (InR), forced expression of which completely rescues lin-28-associated defects in intestinal stem cell number and division pattern. Furthermore, this stem cell activity of lin-28 is independent of one well-known lin-28 target, the microRNA let-7, which has limited expression in the intestinal epithelium. These results identify Lin-28 as a stem cell intrinsic factor that boosts insulin signaling in intestinal progenitor cells and promotes their symmetric division in response to nutrients, defining a mechanism through which Lin-28 controls the adult stem cell division patterns that underlie tissue homeostasis and regeneration.

  11. Lin-28 promotes symmetric stem cell division and drives adaptive growth in the adult Drosophila intestine

    PubMed Central

    Chen, Ching-Huan; Luhur, Arthur; Sokol, Nicholas

    2015-01-01

    Stem cells switch between asymmetric and symmetric division to expand in number as tissues grow during development and in response to environmental changes. The stem cell intrinsic proteins controlling this switch are largely unknown, but one candidate is the Lin-28 pluripotency factor. A conserved RNA-binding protein that is downregulated in most animals as they develop from embryos to adults, Lin-28 persists in populations of adult stem cells. Its function in these cells has not been previously characterized. Here, we report that Lin-28 is highly enriched in adult intestinal stem cells in the Drosophila intestine. lin-28 null mutants are homozygous viable but display defects in this population of cells, which fail to undergo a characteristic food-triggered expansion in number and have reduced rates of symmetric division as well as reduced insulin signaling. Immunoprecipitation of Lin-28-bound mRNAs identified Insulin-like Receptor (InR), forced expression of which completely rescues lin-28-associated defects in intestinal stem cell number and division pattern. Furthermore, this stem cell activity of lin-28 is independent of one well-known lin-28 target, the microRNA let-7, which has limited expression in the intestinal epithelium. These results identify Lin-28 as a stem cell intrinsic factor that boosts insulin signaling in intestinal progenitor cells and promotes their symmetric division in response to nutrients, defining a mechanism through which Lin-28 controls the adult stem cell division patterns that underlie tissue homeostasis and regeneration. PMID:26487778

  12. MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

    PubMed Central

    Beckers, Anneleen; Van Peer, Gert; Carter, Daniel R.; Gartlgruber, Moritz; Herrmann, Carl; Agarwal, Saurabh; Helsmoortel, Hetty H.; Althoff, Kristina; Molenaar, Jan J.; Cheung, Belamy B.; Schulte, Johannes H.; Benoit, Yves; Shohet, Jason M.; Westermann, Frank; Marshall, Glenn M.; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank

    2016-01-01

    LIN28B has been identified as an oncogene in various tumor entities, including neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is characterized by amplification of the MYCN oncogene. Recently, elevated LIN28B expression levels were shown to contribute to neuroblastoma tumorigenesis via let-7 dependent de-repression of MYCN. However, additional insight in the regulation of LIN28B in neuroblastoma is lacking. Therefore, we have performed a comprehensive analysis of the regulation of LIN28B in neuroblastoma, with a specific focus on the contribution of miRNAs. We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. First, through an unbiased LIN28B-3′UTR reporter screen, we found that miR-26a-5p and miR-26b-5p regulate LIN28B expression. Next, we demonstrated that MYCN indirectly affects the expression of miR-26a-5p, and hence regulates LIN28B, therefor establishing a MYCN-miR-26a-5p-LIN28B regulatory axis. Second, we provide evidence that MYCN regulates LIN28B expression via interaction with the LIN28B promotor, establishing a direct MYCN-LIN28B regulatory axis. We believe that these findings mark LIN28B as an important effector of the MYCN oncogenic phenotype and underlines the importance of MYCN-regulated miRNAs in establishing the MYCN-driven oncogenic process. PMID:26123663

  13. The editor-referee system and publication an editor's view of the process

    NASA Astrophysics Data System (ADS)

    Shore, S. N.

    2011-07-01

    This chapter explains the functioning of scientific journals from the editorial side of the process. Both the history and current functioning of scientific journals are reviewed with a particular emphasis on the evolution of the referee's role. In its current form, the evaluation of a submission is interactive between the three parties - the author(s), editors, and reviewers. The editors serve as the mediators and final evaluators, seeking advice from one or more contacted experts who are in the special position of evaluating the science, presentation, and significance of the work. The chapter explains how this proceeds, and its advantages, pitfalls, and criteria - scientific, archival, and ethical - and how these have evolved historically and consensually. Since referees and editors are also authors, the symbiosis of the process is one of its strengths, since all participants exchange roles.

  14. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-04-01

    From the Board of Editors: on Plagiarism

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur

  15. A Network of Genes Antagonistic to the LIN-35 Retinoblastoma Protein of Caenorhabditis elegans

    PubMed Central

    Polley, Stanley R. G.; Fay, David S.

    2012-01-01

    The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified in genetic screens for mutations that display synthetic phenotypes in conjunction with loss of lin-35. To explore the intestinal role of LIN-35, we conducted a genome-wide RNA-interference-feeding screen for suppressors of lin-35; slr-2 early larval arrest. Of the 26 suppressors identified, 17 fall into three functional classes: (1) ribosome biogenesis genes, (2) mitochondrial prohibitins, and (3) chromatin regulators. Further characterization indicates that different categories of suppressors act through distinct molecular mechanisms. We also tested lin-35; slr-2 suppressors, as well as suppressors of the synthetic multivulval phenotype, to determine the spectrum of lin-35-synthetic phenotypes that could be suppressed following inhibition of these genes. We identified 19 genes, most of which are evolutionarily conserved, that can suppress multiple unrelated lin-35-synthetic phenotypes. Our study reveals a network of genes broadly antagonistic to LIN-35 as well as genes specific to the role of LIN-35 in intestinal and vulval development. Suppressors of multiple lin-35 phenotypes may be candidate targets for anticancer therapies. Moreover, screening for suppressors of phenotypically distinct synthetic interactions, which share a common altered gene, may prove to be a novel and effective approach for identifying genes whose activities are most directly relevant to the core functions of the shared gene. PMID:22542970

  16. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-03-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially similar scientific content

  17. MPS Editor - An Integrated Sequencing Environment

    NASA Technical Reports Server (NTRS)

    Streiffert, Barbara A.; O'Reilly, Taifun; Schrock, Mitchell; Catchen, Jaime

    2010-01-01

    In today's operations environment, the teams are smaller and need to be more efficient while still ensuring the safety and success of the mission. In addition, teams often begin working on a mission in its early development phases and continue on the team through actual operations. For these reasons the operations teams want to be presented with a software environment that integrates multiple needed software applications as well as providing them with context sensitive editing support for entering commands and sequences of commands. At Jet Propulsion Laboratory, the Multi-Mission Planning and Sequencing (MPS) Editor provided by the Multi-Mission Ground Systems and Services (MGSS) supports those operational needs.

  18. LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans

    PubMed Central

    Tu, Ho-Chou; Schwitalla, Sarah; Qian, Zhirong; LaPier, Grace S.; Yermalovich, Alena; Ku, Yuan-Chieh; Chen, Shann-Ching; Viswanathan, Srinivas R.; Zhu, Hao; Nishihara, Reiko; Inamura, Kentaro; Kim, Sun A.; Morikawa, Teppei; Mima, Kosuke; Sukawa, Yasutaka; Yang, Juhong; Meredith, Gavin; Fuchs, Charles S.; Ogino, Shuji

    2015-01-01

    Colorectal cancer (CRC) remains a major contributor to cancer-related mortality. LIN28A and LIN28B are highly related RNA-binding protein paralogs that regulate biogenesis of let-7 microRNAs and influence development, metabolism, tissue regeneration, and oncogenesis. Here we demonstrate that overexpression of either LIN28 paralog cooperates with the Wnt pathway to promote invasive intestinal adenocarcinoma in murine models. When LIN28 alone is induced genetically, half of the resulting tumors harbor Ctnnb1 (β-catenin) mutation. When overexpressed in ApcMin/+ mice, LIN28 accelerates tumor formation and enhances proliferation and invasiveness. In conditional genetic models, enforced expression of a LIN28-resistant form of the let-7 microRNA reduces LIN28-induced tumor burden, while silencing of LIN28 expression reduces tumor volume and increases tumor differentiation, indicating that LIN28 contributes to tumor maintenance. We detected aberrant expression of LIN28A and/or LIN28B in 38% of a large series of human CRC samples (n = 595), where LIN28 expression levels were associated with invasive tumor growth. Our late-stage CRC murine models and analysis of primary human tumors demonstrate prominent roles for both LIN28 paralogs in promoting CRC growth and progression and implicate the LIN28/let-7 pathway as a therapeutic target. PMID:25956904

  19. The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity.

    PubMed

    Kidd, Ambrose R; Muñiz-Medina, Vanessa; Der, Channing J; Cox, Adrienne D; Reiner, David J

    2015-01-01

    Wnt signaling controls various aspects of developmental and cell biology, as well as contributing to certain cancers. Expression of the human Rho family small GTPase Wrch/RhoU is regulated by Wnt signaling, and Wrch and its paralog Chp/RhoV are both implicated in oncogenic transformation and regulation of cytoskeletal dynamics. We performed developmental genetic analysis of the single Caenorhabditis elegans ortholog of Chp and Wrch, CHW-1. Using a transgenic assay of the distal tip cell migration, we found that wild-type CHW-1 is likely to be partially constitutively active and that we can alter ectopic CHW-1-dependent migration phenotypes with mutations predicted to increase or decrease intrinsic GTP hydrolysis rate. The vulval P7.p polarity decision balances multiple antagonistic Wnt signals, and also uses different types of Wnt signaling. Previously described cooperative Wnt receptors LIN-17/Frizzled and LIN-18/Ryk orient P7.p posteriorly, with LIN-17/Fz contributing approximately two-thirds of polarizing activity. CHW-1 deletion appears to equalize the contributions of these two receptors. We hypothesize that CHW-1 increases LIN-17/Fz activity at the expense of LIN-18/Ryk, thus making the contribution of these signals unequal. For P7.p to polarize correctly and form a proper vulva, LIN-17/Fz and LIN-18/Ryk antagonize other Wnt transmembrane systems VANG-1/VanGogh and CAM-1/Ror. Our genetic data suggest that LIN-17/Fz represses both VANG-1/VanGogh and CAM-1/Ror, while LIN-18/Ryk represses only VANG-1. These data expand our knowledge of a sophisticated signaling network to control P7.p polarity, and suggests that CHW-1 can alter ligand gradients or receptor priorities in the system. PMID:26208319

  20. The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity

    PubMed Central

    Kidd, Ambrose R.; Muñiz-Medina, Vanessa; Der, Channing J.; Cox, Adrienne D.; Reiner, David J.

    2015-01-01

    Wnt signaling controls various aspects of developmental and cell biology, as well as contributing to certain cancers. Expression of the human Rho family small GTPase Wrch/RhoU is regulated by Wnt signaling, and Wrch and its paralog Chp/RhoV are both implicated in oncogenic transformation and regulation of cytoskeletal dynamics. We performed developmental genetic analysis of the single Caenorhabditis elegans ortholog of Chp and Wrch, CHW-1. Using a transgenic assay of the distal tip cell migration, we found that wild-type CHW-1 is likely to be partially constitutively active and that we can alter ectopic CHW-1-dependent migration phenotypes with mutations predicted to increase or decrease intrinsic GTP hydrolysis rate. The vulval P7.p polarity decision balances multiple antagonistic Wnt signals, and also uses different types of Wnt signaling. Previously described cooperative Wnt receptors LIN-17/Frizzled and LIN-18/Ryk orient P7.p posteriorly, with LIN-17/Fz contributing approximately two-thirds of polarizing activity. CHW-1 deletion appears to equalize the contributions of these two receptors. We hypothesize that CHW-1 increases LIN-17/Fz activity at the expense of LIN-18/Ryk, thus making the contribution of these signals unequal. For P7.p to polarize correctly and form a proper vulva, LIN-17/Fz and LIN-18/Ryk antagonize other Wnt transmembrane systems VANG-1/VanGogh and CAM-1/Ror. Our genetic data suggest that LIN-17/Fz represses both VANG-1/VanGogh and CAM-1/Ror, while LIN-18/Ryk represses only VANG-1. These data expand our knowledge of a sophisticated signaling network to control P7.p polarity, and suggests that CHW-1 can alter ligand gradients or receptor priorities in the system. PMID:26208319

  1. TsLIN-3/3500 electromagnetic pump

    SciTech Connect

    Andreev, A.M.; Bezgachev, E.A.; Karasev, B.G.; Kirillov, I.R.; Ogorodnikov, A.P.; Preslitskii, G.V.; Chvartatskii, R.V.

    1988-07-01

    Test results for the TsLIN-3/3500 electromagnetic pump, built for experimental use in one of the secondary loops in the BN-350 reactor, are considered. Design and operating parameters are also given. The tests consisted of thermal, mechanical, hydraulic, and vibration and noise regimes. The scope for starting the pump with a gas bubble in the upper part of the channel was also examined. Measurements were also made on the transient state, supply disconnection, and simulation of the changes due to shift in supply voltage.

  2. Dynamics of multiple lin gene expression in Sphingomonas paucimobilis B90A in response to different hexachlorocyclohexane isomers.

    PubMed

    Suar, Mrutyunjay; van der Meer, Jan Roelof; Lawlor, Kirsten; Holliger, Christof; Lal, Rup

    2004-11-01

    Sphingomonas paucimobilis B90A is able to degrade the alpha-, beta-, gamma-, and delta-isomers of hexachlorocyclohexane (HCH). It contains the genes linA, linB, linC, linD, linE, and linR, which have been implicated in HCH degradation. In this study, dynamic expression of the lin genes was measured in chemostat-grown S. paucimobilis B90A by RNA dot blot hybridization and real-time reverse transcriptase PCR upon exposure to a pulse of different HCH isomers. Irrespective of the addition of HCH, linA, linB, and linC were all expressed constitutively. In contrast, linD and linE were induced with alpha-HCH (2 mg/liter) and gamma-HCH (7 mg/liter). A sharp increase in mRNA levels for linD and linE was observed from 10 to 45 min after the addition of alpha- or gamma-HCH. Induction of linD and linE was not detectable upon the addition of 0.7 mg of gamma-HCH per liter, although the compound was degraded by the cells. The addition of beta-HCH (5 mg/liter) or delta-HCH (20 mg/liter) did not lead to linE and linD induction, despite the fact that 50% of the compounds were degraded. This suggests that degradation of beta- and delta-HCH proceeds by a different pathway than that of alpha- and gamma-HCH.

  3. A Tisket, A Tasket--Out of the Editor's Basket

    NASA Astrophysics Data System (ADS)

    Williams, Kathryn R.

    2001-05-01

    In September 1940, the Journal introduced Out of the Editor's Basket for short items of interest: excerpts from letters, pamphlets, newspapers, and periodicals. By 1950, however, the Editor's Basket had evolved into a bulletin board for descriptions of new products and services, and it now contains almost exclusively press releases about recently marketed items. Now over 60 years old, the Editor's Basket still provides interesting tidbits for the Journal's broad readership.

  4. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-05-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially

  5. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-04-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially

  6. EDITORIAL: Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Lidström, Suzanne

    2012-04-01

    When Professor Anders Bárány took over as the Executive Editor of Physica Scripta, in 1986, he talked of his trepidation at having to 'dress himself' in his predecessor's 'editorial coveralls'. At that time, they had been worn by Professor Nils Robert Nilsson, a major figure in the physics community, for almost 20 years. Just one year prior to this, Professor Roger Wäppling had been recruited to the position of Subeditor in conjunction with a decision to expand the number of contributions in the field of condensed matter physics, to turn it into one of the dominant subjects in the broad-based journal. Physica Scripta had already gained a reputation for being a high quality journal with wide coverage of both experimental and theoretical physics. Interestingly, in the mid 1980s, the number of papers submitted had been growing and an impressive 250 submissions per year had been attained, with all of the manuscripts being handled in-house. Not many miles away in the town of Uppsala, a group of English students was stepping off a train on a magnificent snowy day in January to embark on their final year projects. A couple of us enjoyed ourselves so much that we stayed on afterwards as PhD students, thereby encountering the mixed pleasure of studying physics in a second language for the first time. I used to copy the notes down meticulously in Swedish, then try to work backwards with a textbook to improve my language skills. One day, returning from a particularly incomprehensible lecture on solid state physics, I showed my roommates my notes and asked if they could please explain what the lecture had been about: 'I don't know', they replied, 'but this bit is about sheep!' Meanwhile, back at Physica Scripta, the journal continued to flourish: 400 submissions were received in 1996, and the march of progress was well underway. Manuscripts could now be sent in on disks and Physica Scripta was available on the World Wide Web. Roger was appointed to manage the journal and

  7. Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development

    PubMed Central

    Vogt, Edgar J.; Meglicki, Maciej; Hartung, Kristina Ilka; Borsuk, Ewa; Behr, Rüdiger

    2012-01-01

    The maternal nucleolus is required for proper activation of the embryonic genome (EGA) and early embryonic development. Nucleologenesis is characterized by the transformation of a nucleolar precursor body (NPB) to a mature nucleolus during preimplantation development. However, the function of NPBs and the involved molecular factors are unknown. We uncover a novel role for the pluripotency factor LIN28, the biological significance of which was previously demonstrated in the reprogramming of human somatic cells to induced pluripotent stem (iPS) cells. Here, we show that LIN28 accumulates at the NPB and the mature nucleolus in mouse preimplantation embryos and embryonic stem cells (ESCs), where it colocalizes with the nucleolar marker B23 (nucleophosmin 1). LIN28 has nucleolar localization in non-human primate (NHP) preimplantation embryos, but is cytoplasmic in NHP ESCs. Lin28 transcripts show a striking decline before mouse EGA, whereas LIN28 protein localizes to NPBs at the time of EGA. Following knockdown with a Lin28 morpholino, the majority of embryos arrest between the 2- and 4-cell stages and never develop to morula or blastocyst. Lin28 morpholino-injected embryos arrested at the 2-cell stage were not enriched with nucleophosmin at presumptive NPB sites, indicating that functional NPBs were not assembled. Based on these results, we propose that LIN28 is an essential factor of nucleologenesis during early embryonic development. PMID:23172912

  8. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.

    PubMed

    Shinoda, Gen; Shyh-Chang, Ng; Soysa, T Yvanka de; Zhu, Hao; Seligson, Marc T; Shah, Samar P; Abo-Sido, Nora; Yabuuchi, Akiko; Hagan, John P; Gregory, Richard I; Asara, John M; Cantley, Lewis C; Moss, Eric G; Daley, George Q

    2013-08-01

    LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over-expression of Lin28a have shown related phenotypes. Here, we describe the first comprehensive analysis of the physiologic consequences of Lin28a and Lin28b deficiency in knockout (KO) mice. Lin28a/b-deficiency led to dwarfism starting at different ages, and compound gene deletions showed a cumulative dosage effect on organismal growth. Conditional gene deletion at specific developmental stages revealed that fetal but neither neonatal nor adult deficiency resulted in growth defects and aberrations in glucose metabolism. Tissue-specific KO mice implicated skeletal muscle-deficiency in the abnormal programming of adult growth and metabolism. The effects of Lin28b KO could be rescued by Tsc1 haplo-insufficiency in skeletal muscles. Our data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth, and demonstrate that fetal Lin28b acts at least in part via mTORC1 signaling.

  9. Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development.

    PubMed

    Vogt, Edgar J; Meglicki, Maciej; Hartung, Kristina Ilka; Borsuk, Ewa; Behr, Rüdiger

    2012-12-01

    The maternal nucleolus is required for proper activation of the embryonic genome (EGA) and early embryonic development. Nucleologenesis is characterized by the transformation of a nucleolar precursor body (NPB) to a mature nucleolus during preimplantation development. However, the function of NPBs and the involved molecular factors are unknown. We uncover a novel role for the pluripotency factor LIN28, the biological significance of which was previously demonstrated in the reprogramming of human somatic cells to induced pluripotent stem (iPS) cells. Here, we show that LIN28 accumulates at the NPB and the mature nucleolus in mouse preimplantation embryos and embryonic stem cells (ESCs), where it colocalizes with the nucleolar marker B23 (nucleophosmin 1). LIN28 has nucleolar localization in non-human primate (NHP) preimplantation embryos, but is cytoplasmic in NHP ESCs. Lin28 transcripts show a striking decline before mouse EGA, whereas LIN28 protein localizes to NPBs at the time of EGA. Following knockdown with a Lin28 morpholino, the majority of embryos arrest between the 2- and 4-cell stages and never develop to morula or blastocyst. Lin28 morpholino-injected embryos arrested at the 2-cell stage were not enriched with nucleophosmin at presumptive NPB sites, indicating that functional NPBs were not assembled. Based on these results, we propose that LIN28 is an essential factor of nucleologenesis during early embryonic development.

  10. LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.

    PubMed

    Shaye, Daniel D; Greenwald, Iva

    2005-11-01

    A novel mode of crosstalk between the EGFR-Ras-MAPK and LIN-12/Notch pathways occurs during the patterning of a row of vulval precursor cells (VPCs) in Caenorhabditis elegans: activation of the EGFR-Ras-MAPK pathway in the central VPC promotes endocytosis and degradation of LIN-12 protein. LIN-12 downregulation in the central VPC is a prerequisite for the activity of the lateral signal, which activates LIN-12 in neighboring VPCs. Here we characterize cis-acting targeting sequences in the LIN-12 intracellular domain and find that in addition to a di-leucine motif, serine/threonine residues are important for internalization and lysine residues are important for post-internalization trafficking and degradation. We also identify two trans-acting factors that are required for post-internalization trafficking and degradation: ALX-1, a homolog of yeast Bro1p and mammalian Alix and the WWP-1/Su(dx)/Itch ubiquitin ligase. By examining the effects of mutated forms of LIN-12 and reduced wwp-1 or alx-1 activity on subcellular localization and activity of LIN-12, we provide evidence that the lateral signal-inhibiting activity of LIN-12 resides in the extracellular domain and occurs at the apical surface of the VPCs.

  11. Clinicopathological Characteristics of Patients with Gastric Cancer according to the Expression of LIN28A

    PubMed Central

    Park, Chan Hyuk; Lee, Jung Hwa; Lee, Na Keum; Lee, Yong Chan; Lee, Sang Kil

    2016-01-01

    Background/Aims Although LIN28A is known to potentially play a role in the oncogenesis of various cancers, whether LIN28A expression is a predictor of poor prognosis in patients with gastric cancer has not been fully explored. We sought to evaluate clinicopathological characteristics according to the expression of LIN28A in numerous gastric cancer tissue samples. Methods LIN28A expression was evaluated by immunohistochemical (IHC) analysis of a tissue microarray comprising 288 gastric cancer tissues and 288 adjacent normal tissues. Clinicopathological characteristics, including overall survival, were compared according to LIN28A expression. Results The IHC staining score was lower for the cancer tissues than the normal tissues (p<0.001). However, no significant differences were observed in the clinicopathological characteristics between the low and high LIN28A expression groups. In addition, the 5-year overall survival rate did not differ between the two groups: 75.3% (95% confidence interval [CI], 69.3% to 81.7%) versus 71.6% (95% CI, 63.3% to 80.9%) for low versus high expression, respectively. Conclusions The expression of LIN28A did not appear to play a distinct role in predicting the clinicopathological characteristics of patients with gastric cancer. In addition, LIN28A expression was not an independently associated factor for overall survival in patients with gastric cancer. PMID:26893371

  12. John F. Dewey—Tectonics Editor

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    ‘I want the journal to acquire a reputation for very rapid, fair, and accurate reviewing,’ asserted John F. Dewey, editor-in-chief of AGU's newest journal, Tectonics. Dewey said that he will rule the bimonthly, which will begin publication in February, ‘with a bit of a rod of iron’ to ensure that Tectonics is ‘where only original and important papers are published.’‘I'm going to be very strict with reviewers,’ Dewey explained in his quick British clip. ‘If the review does not come back to me within 10 days to 2 weeks, I'll review the paper myself. I'm also going to have a system whereby, if a paper needs major surgery after being refereed, it will be rejected. Papers will have to be in virtually publishable condition before they are first submitted,’ he said.

  13. Advisers, Editors and Principals Judge First Amendment Cases.

    ERIC Educational Resources Information Center

    Broussard, E. Joseph; Blackmon, C. Robert

    1978-01-01

    A test of the knowledge of 378 high school publications advisers, editors, and principals regarding First Amendment rights revealed that advisers had the most knowledge, followed by editors and then by principals. Characteristics of the most knowledgeable advisers were then identified. (GT)

  14. Peer reviews and the role of a journal editor

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Obtaining peer reviews for manuscripts submitted to scientific journals is becoming increasingly difficult. Changes to the system are necessary, and editors must cultivate and maintain a solid base of reviewers to help evaluate journal submissions. This article outlines some steps editors can and sh...

  15. Journal Editor Perceptions of Universities: Some Empirical Evidence

    ERIC Educational Resources Information Center

    Mainardes, Emerson Wagner; Raposo, Mario; Alves, Helena

    2012-01-01

    Out of considerations as to the importance of university relationships with their various stakeholders, the primary objective of this research project was to identify the perceptions of academic journal editors regarding universities. Editors were asked to provide their perceptions on: (a) the relevance of universities to academic publications;…

  16. Newspaper Ethics and Managing Editors: The Evolution of APME's Code.

    ERIC Educational Resources Information Center

    De Mott, John

    A review of the 42-year development of the professional code of ethics of the Associated Press Managing Editors (APME) demonstrates an effort to elevate newspaper ethical standards around the country. Following the example of the American Society of Newspaper Editors in establishing its "Canons of Journalism" in 1923, the APME formed a criteria…

  17. How Managing Editors View and Deal with Newspaper Ethical Issues.

    ERIC Educational Resources Information Center

    Anderson, Douglas

    1987-01-01

    Claims there is awareness and concern about journalism ethics among daily newspaper managing editors. Asserts that although ethical issues are being addressed to some degree, greater efforts could be made to see that reporters and editors are apprised of codes of ethics. (MM)

  18. Editors and author resource centers actively used by attendees

    NASA Astrophysics Data System (ADS)

    Major, Barbara

    2012-02-01

    At the 2011 Fall Meeting, as in previous years, the Editors Resource Center located on the second floor of Moscone West was buzzing with activity: editors talking with other editors, collaborating with associate editors, speaking with authors, and meeting with students. In addition, several editors took part in "Meet the Editor" informal sessions, a new feature introduced for the 2011 meeting to strengthen the partnership between authors and editors. The map "Where are you from?" (see photo), outside the Editors Resource Center, drew the attention of many attendees who were eager to place their colored dots on the map. The Author Resource Center, located in the AGU Marketplace, became a hub for AGU veteran authors and potential authors alike. Staff were there to answer both editorial and technical questions, especially the most frequent one: What happens after my paper is accepted? The running slideshow that described all aspects of the AGU publications program sparked a myriad of questions, which AGU staff were happy to answer.

  19. COBrA: a bio-ontology editor.

    PubMed

    Aitken, Stuart; Korf, Roman; Webber, Bonnie; Bard, Jonathan

    2005-03-01

    COBrA is a Java-based ontology editor for bio-ontologies that distinguishes itself from other editors by supporting the linking of concepts between two ontologies, and providing sophisticated analysis and verification functions. In addition to the Gene Ontology and Open Biology Ontologies formats, COBrA can import and export ontologies in the Semantic Web formats RDF, RDFS and OWL.

  20. Cloning and characterization of lin genes responsible for the degradation of Hexachlorocyclohexane isomers by Sphingomonas paucimobilis strain B90.

    PubMed

    Kumari, Rekha; Subudhi, Sanjukta; Suar, Mrutyunjay; Dhingra, Gauri; Raina, Vishakha; Dogra, Charu; Lal, Sukanya; van der Meer, Jan Roelof; Holliger, Christof; Lal, Rup

    2002-12-01

    Hexachlorocyclohexane (HCH) has been used extensively against agricultural pests and in public health programs for the control of mosquitoes. Commercial formulations of HCH consist of a mixture of four isomers, alpha, beta, gamma, and delta. While all these isomers pose serious environmental problems, beta-HCH is more problematic due to its longer persistence in the environment. We have studied the degradation of HCH isomers by Sphingomonas paucimobilis strain B90 and characterized the lin genes encoding enzymes from strain B90 responsible for the degradation of HCH isomers. Two nonidentical copies of the linA gene encoding HCH dehydrochlorinase, which were designated linA1 and linA2, were found in S. paucimobilis B90. The linA1 and linA2 genes could be expressed in Escherichia coli, leading to dehydrochlorination of alpha-, gamma-, and delta-HCH but not of beta-HCH, suggesting that S. paucimobilis B90 contains another pathway for the initial steps of beta-HCH degradation. The cloning and characterization of the halidohydrolase (linB), dehydrogenase (linC and linX), and reductive dechlorinase (linD) genes from S. paucimobilis B90 revealed that they share approximately 96 to 99% identical nucleotides with the corresponding genes of S. paucimobilis UT26. No evidence was found for the presence of a linE-like gene, coding for a ring cleavage dioxygenase, in strain B90. The gene structures around the linA1 and linA2 genes of strain B90, compared to those in strain UT26, are suggestive of a recombination between linA1 and linA2, which formed linA of strain UT26.

  1. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    NASA Astrophysics Data System (ADS)

    Cardona, Manuel

    2005-03-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  2. EDITORIAL: Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Lidström, Suzanne

    2012-04-01

    When Professor Anders Bárány took over as the Executive Editor of Physica Scripta, in 1986, he talked of his trepidation at having to 'dress himself' in his predecessor's 'editorial coveralls'. At that time, they had been worn by Professor Nils Robert Nilsson, a major figure in the physics community, for almost 20 years. Just one year prior to this, Professor Roger Wäppling had been recruited to the position of Subeditor in conjunction with a decision to expand the number of contributions in the field of condensed matter physics, to turn it into one of the dominant subjects in the broad-based journal. Physica Scripta had already gained a reputation for being a high quality journal with wide coverage of both experimental and theoretical physics. Interestingly, in the mid 1980s, the number of papers submitted had been growing and an impressive 250 submissions per year had been attained, with all of the manuscripts being handled in-house. Not many miles away in the town of Uppsala, a group of English students was stepping off a train on a magnificent snowy day in January to embark on their final year projects. A couple of us enjoyed ourselves so much that we stayed on afterwards as PhD students, thereby encountering the mixed pleasure of studying physics in a second language for the first time. I used to copy the notes down meticulously in Swedish, then try to work backwards with a textbook to improve my language skills. One day, returning from a particularly incomprehensible lecture on solid state physics, I showed my roommates my notes and asked if they could please explain what the lecture had been about: 'I don't know', they replied, 'but this bit is about sheep!' Meanwhile, back at Physica Scripta, the journal continued to flourish: 400 submissions were received in 1996, and the march of progress was well underway. Manuscripts could now be sent in on disks and Physica Scripta was available on the World Wide Web. Roger was appointed to manage the journal and

  3. Bacterial diversity and real-time PCR based assessment of linA and linB gene distribution at hexachlorocyclohexane contaminated sites.

    PubMed

    Lal, Devi; Jindal, Swati; Kumari, Hansi; Jit, Simran; Nigam, Aeshna; Sharma, Pooja; Kumari, Kirti; Lal, Rup

    2015-03-01

    The disposal of hexachlorocyclohexane (HCH) muck has created large number of HCH dumpsites all over the world from where the harmful HCH isomers are leaking into the environment. Bacteria have evolved at such contaminated sites that have the ability to degrade HCH. Degradation of various HCH isomers in bacterial strains is mediated primarily by two genes: linA and linB which encode dehydrochlorinase and haloalkane dehalogenase respectively. In this study we explored one such highly contaminated HCH dumpsite located in Lucknow, Uttar Pradesh, India. To assess the biostimulation potential of the contaminated site, microbial diversity study and real-time PCR based quantification of lin genes was carried out. The soil samples from dumpsite and surrounding areas were found to be highly contaminated with HCH residue levels as high as 1.8 × 10(5)  mg kg(-1). The residues were detected in areas upto 13 km from the dumpsite. Sphingomonads, Chromohalobacter, and Marinobacter were the dominant genera present at the dump-site. Role of Sphingomonads in HCH degradation has been well documented. The highest copy numbers of linA and linB genes as determined using real-time PCR were 6.2 × 10(4) and 5.3 × 10(5), respectively, were found in sample from the dump site. The presence of Sphingomonads, linA, and linB genes from HCH contaminated soil indicates the presence of indigenous bacterial communities capable of HCH degradation.

  4. The C. elegans hox gene lin-39 controls cell cycle progression during vulval development.

    PubMed

    Roiz, Daniel; Escobar-Restrepo, Juan Miguel; Leu, Philipp; Hajnal, Alex

    2016-10-01

    Cell fate specification during organogenesis is usually followed by a phase of cell proliferation to produce the required number of differentiated cells. The Caenorhabditis elegans vulva is an excellent model to study how cell fate specification and cell proliferation are coordinated. The six vulval precursor cells (VPCs) are born at the first larval stage, but they arrest in the G1 phase of the cell cycle until the beginning of the third larval stage, when their fates are specified and the three proximal VPCs proliferate to generate 22 vulval cells. An epidermal growth factor (EGF) signal from the gonadal anchor cell combined with lateral DELTA/NOTCH signaling between the VPCs determine the primary (1°) and secondary (2°) fates, respectively. The hox gene lin-39 plays a key role in integrating these spatial patterning signals and in maintaining the VPCs as polarized epithelial cells. Using a fusion-defective eff-1(lf) mutation to keep the VPCs polarized, we find that VPCs lacking lin-39 can neither activate lateral NOTCH signaling nor proliferate. LIN-39 promotes cell cycle progression through two distinct mechanisms. First, LIN-39 maintains the VPCs competent to proliferate by inducing cdk-4 cdk and cye-1 cyclinE expression via a non-canonical HOX binding motif. Second, LIN-39 activates in the adjacent VPCs the NOTCH signaling pathway, which promotes VPC proliferation independently of LIN-39. The hox gene lin-39 is therefore a central node in a regulatory network coordinating VPC differentiation and proliferation.

  5. Starving for more: Nutrient sensing by LIN-28 in adult intestinal progenitor cells.

    PubMed

    Luhur, Arthur; Sokol, Nicholas

    2015-01-01

    In this Extra View, we extend our recent work on the protein LIN-28 and its role in adult stem cell divisions. LIN-28 is an mRNA- and microRNA-binding protein that is conserved from worms to humans. When expressed ectopically, it promotes the reprogramming of differentiated vertebrate cells into pluripotent stem cells as well as the regeneration of vertebrate tissues after injury. However, its endogenous function in stem cell populations is less clear. We recently reported that LIN-28 is specifically expressed in progenitor cells in the adult Drosophila intestine and enhances insulin signaling within this population. Loss of lin-28 alters the division patterns of these progenitor cells, limiting the growth of the intestinal epithelium that is ordinarily caused by feeding. Thus, LIN-28 is part of an uncharacterized circuit used to remodel a tissue in response to environmental cues like nutrition. Here, we extend this analysis by reporting that the levels of LIN-28 in progenitor cells are sensitive to nutrient availability. In addition, we speculate about the role of LIN-28 in the translational control of target mRNAs such as Insulin Receptor (InR) and how such translational control may be an important mechanism that underlies the stem cell dynamics needed for tissue homeostasis and growth.

  6. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea

    PubMed Central

    Golden, Erin J.; Benito-Gonzalez, Ana; Doetzlhofer, Angelika

    2015-01-01

    Proper tissue development requires strict coordination of proliferation, growth, and differentiation. Strict coordination is particularly important for the auditory sensory epithelium, where deviations from the normal spatial and temporal pattern of auditory progenitor cell (prosensory cell) proliferation and differentiation result in abnormal cellular organization and, thus, auditory dysfunction. The molecular mechanisms involved in the timing and coordination of auditory prosensory proliferation and differentiation are poorly understood. Here we identify the RNA-binding protein LIN28B as a critical regulator of developmental timing in the murine cochlea. We show that Lin28b and its opposing let-7 miRNAs are differentially expressed in the auditory sensory lineage, with Lin28b being highly expressed in undifferentiated prosensory cells and let-7 miRNAs being highly expressed in their progeny—hair cells (HCs) and supporting cells (SCs). Using recently developed transgenic mouse models for LIN28B and let-7g, we demonstrate that prolonged LIN28B expression delays prosensory cell cycle withdrawal and differentiation, resulting in HC and SC patterning and maturation defects. Surprisingly, let-7g overexpression, although capable of inducing premature prosensory cell cycle exit, failed to induce premature HC differentiation, suggesting that LIN28B’s functional role in the timing of differentiation uses let-7 independent mechanisms. Finally, we demonstrate that overexpression of LIN28B or let-7g can significantly alter the postnatal production of HCs in response to Notch inhibition; LIN28B has a positive effect on HC production, whereas let-7 antagonizes this process. Together, these results implicate a key role for the LIN28B/let-7 axis in regulating postnatal SC plasticity. PMID:26139524

  7. Crystallization and preliminary X-ray diffraction analysis of Lin1840, a putative β-glucosidase from Listeria innocua.

    PubMed

    Nakajima, Masahiro; Yoshida, Ryuta; Miyanaga, Akimasa; Taguchi, Hayao

    2014-10-01

    Lin1840 is a putative β-glucosidase that is predicted to be involved in 1,2-β-glucan metabolism since the lin1839 gene encoding a 1,2-β-oligoglucan phosphorylase and the lin1840 gene are located in the same gene cluster. Here, Lin1840 was crystallized. The crystals of Lin1840 diffracted to beyond 1.8 Å resolution. The crystal belonged to space group I121, with unit-cell parameters a = 89.75, b = 95.10, c = 215.00 Å, α = 90.00, β = 96.34, γ = 90.00°.

  8. Team of three JGR-Space Physics editors appointed

    NASA Astrophysics Data System (ADS)

    Three editors from the United States, Europe, and Asia have been appointed to lead JGR-Space Physics into the new millennium. This new team will recognize and foster the substantial contributions that scientists from the international community make to the journal. Janet Luhmann, a Senior Fellow at the Space Sciences Laboratory, University of California, Berkeley, will serve as Senior Editor. Luhmann will play a coordinating role for the regional editors, which will be especially important as the Union moves into electronic publishing and adopts new ways of using the technology to publish research findings.

  9. Retirement of J. Gary Eden as Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Jagadish, Chennupati; Jelinkova, Helena; Fainman, Yeshaiahu; Dawson, Martin; Ermers, Ysabel

    2016-01-01

    After nine years of dedicated service as Editor-in-Chief of Progress in Quantum Electronics (PQE), J. Gary Eden has retired at the end of December 2015. During his term as the Editor-in-Chief, PQE has grown significantly in size and quality and he has given generously of his time in advising authors, referees, editors, and the journal staff. Gary is an exceptional scientist and a generous individual who has given so much to the community. He is always very positive in every situation, and has created positive environment and supported people with utmost enthusiasm.

  10. ESDAPT - APT PROGRAMMING EDITOR AND INTERPRETER

    NASA Technical Reports Server (NTRS)

    Premack, T.

    1994-01-01

    ESDAPT is a graphical programming environment for developing APT (Automatically Programmed Tool) programs for controlling numerically controlled machine tools. ESDAPT has a graphical user interface that provides the user with an APT syntax sensitive text editor and windows for displaying geometry and tool paths. APT geometry statement can also be created using menus and screen picks. ESDAPT interprets APT geometry statements and displays the results in its view windows. Tool paths are generated by batching the APT source to an APT processor (COSMIC P-APT recommended). The tool paths are then displayed in the view windows. Hardcopy output of the view windows is in color PostScript format. ESDAPT is written in C-language, yacc, lex, and XView for use on Sun4 series computers running SunOS. ESDAPT requires 4Mb of disk space, 7Mb of RAM, and MIT's X Window System, Version 11 Release 4, or OpenWindows version 3 for execution. Program documentation in PostScript format and an executable for OpenWindows version 3 are provided on the distribution media. The standard distribution medium for ESDAPT is a .25 inch streaming magnetic tape cartridge (Sun QIC-24) in UNIX tar format. This program was developed in 1992.

  11. EDITORIAL: Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Webb, Steve

    2006-01-01

    Physics in Medicine and Biology (PMB) is a journal that originated in the UK but is now rightly regarded as one of the pre-eminent international journals for the publication of material coming within its remit. It is 50 years old and its maturity is an outcome of the consistent support of high performing authors, a supportive and professional publishing house, dedicated referees, many vigorous and conscientious editorial boards and the collective input of the 10 previous Editors as listed in his incoming editorial (January 2000 issue) by the retiring Editor, Professor Alun Beddoe. The scientific climate and it associated publication modus operandi in the 1950s was very different from that at the current time and the journal has evolved to reflect this. Hence today the scope of content is somewhat broader, the size of the journal is vastly greater, the whole publication process is slicker and more efficient and a paper in PMB is highly prized by its authors and those who look to quality factors and impact. The quality of the journal still relies on the voluntary labour and expertise of its busy international referees and Board members. For many years I have tried to place my own research material in PMB and encourage my teams to do likewise, not only acknowledging the prestige of the journal but also because of the extraordinarily fast turnaround time of all the processes without any loss of quality. This serves us very well and the publishing team are to be congratulated. Some things seem to change more slowly or not at all, however. The prediction, when I started my research career, that books and journals would be dinosaurs by now has manifestly not come true and, whilst most of us are addicted (and why not?) to the electronic ways of doing things that can be done by more traditional ways, PMB and a packet of reprints from time to time arriving by post still has a reassuring feel despite the fact that the papers have been `on-line' for a while before. An incoming

  12. EDITORIAL: Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Webb, Steve

    2006-01-01

    Physics in Medicine and Biology (PMB) is a journal that originated in the UK but is now rightly regarded as one of the pre-eminent international journals for the publication of material coming within its remit. It is 50 years old and its maturity is an outcome of the consistent support of high performing authors, a supportive and professional publishing house, dedicated referees, many vigorous and conscientious editorial boards and the collective input of the 10 previous Editors as listed in his incoming editorial (January 2000 issue) by the retiring Editor, Professor Alun Beddoe. The scientific climate and it associated publication modus operandi in the 1950s was very different from that at the current time and the journal has evolved to reflect this. Hence today the scope of content is somewhat broader, the size of the journal is vastly greater, the whole publication process is slicker and more efficient and a paper in PMB is highly prized by its authors and those who look to quality factors and impact. The quality of the journal still relies on the voluntary labour and expertise of its busy international referees and Board members. For many years I have tried to place my own research material in PMB and encourage my teams to do likewise, not only acknowledging the prestige of the journal but also because of the extraordinarily fast turnaround time of all the processes without any loss of quality. This serves us very well and the publishing team are to be congratulated. Some things seem to change more slowly or not at all, however. The prediction, when I started my research career, that books and journals would be dinosaurs by now has manifestly not come true and, whilst most of us are addicted (and why not?) to the electronic ways of doing things that can be done by more traditional ways, PMB and a packet of reprints from time to time arriving by post still has a reassuring feel despite the fact that the papers have been `on-line' for a while before. An incoming

  13. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    NASA Astrophysics Data System (ADS)

    Cardona, Manuel

    2005-02-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  14. Editorial independence and the editor-owner relationship: good editors never die, they just cross the line.

    PubMed

    Lapeña, J F

    2009-12-01

    The concept of editorial freedom or independence is examined in the light of the editor-owner relationship. Like individual and national freedom or independence, it is a rhetorical concept whose realisation flows from internal achievement as much as it depends on external validation. This freedom entails roles and responsibilities embodied in specific codes of practice for editors, such as the guidelines espoused by the International Committee of Medical Journal Editors and the World Association of Medical Editors. The calling to embody these guidelines makes editing a vocation that demands isolation and distancing, separation and solitude. It involves bracketing one's biases, prejudgments and preconceptions. With such detachment comes real freedom; one that requires a moral fibre and trustworthiness that uphold truth and right, whether in full view of public scrutiny, or in the aloneness of private secrecy. The stereotypical tension between academic and commercial concerns highlights the editor-owner relationship, and bears directly on editorial independence. In practice, journal owners overstep their prerogatives. The absence of clear contracts defining editorial independence and the lack of established mechanisms governing the editor-owner relationship affect many small- to medium-sized journals in developing countries. Even large journals in developed and democratic nations or totalitarian states and societies are not spared. At the end of the day, editorial freedom exists only insofar as it is tolerated, or until editors cross the line. PMID:20087545

  15. Bibliography or Bust: The "Angst" of Scholarly Editors.

    ERIC Educational Resources Information Center

    Costa, Richard Hauer

    1980-01-01

    Provides evidence indicating not only that the market for articles on literature and language is saturated with submissions, but that the glut creates burgeoning problems for editors, including the problem of rejecting publishable items. (RL)

  16. Developing Taste and Judgment: Correctness and the Technical Editor.

    ERIC Educational Resources Information Center

    Amsden, Dorothy Corner; Sanders, Scott P.

    1985-01-01

    Provides a practical discussion for an editing course of the manner in which editors and writers routinely consult reference tools as they work and use what they find as the basis for editorial judgment and creativity. (HTH)

  17. Adapting a thesis to publication style: meeting editors' expectations.

    PubMed

    Johnson, S H

    1996-01-01

    Every year hundreds of thesis reports are completed by graduate students. Many of these end up on nursing journal editors' desks, only to be rejected. What characteristics of a thesis lead to rejection? How can authors develop quality research manuscripts? How can faculty teach graduate students the difference between a thesis and manuscript. This article answers these questions by providing advice from 15 critical care and research journal editors.

  18. ANNOUNCEMENT: Greetings from the Editor and Publisher

    NASA Astrophysics Data System (ADS)

    Wäppling, Roger; Williams, Sarah

    2006-01-01

    Physica Scripta is an international physics journal published for the Royal Swedish Academy of Sciences on behalf of the Nordic Science Academies and Physical Societies. This issue marks the beginning of the partnership between the Royal Swedish Academy of Sciences and Institute of Physics Publishing (IOP). We look forward to a fruitful relationship in which Physica Scripta can profit from the international reach of IOP. Authors and readers will benefit from advance publication of articles on the web prior to receiving each month's journal issue. The peer-review system will continue to be managed by Professor Roger Wäppling who will assess each paper before assigning it to an external editor or sending it for refereeing. IOP will receive new article submissions and generate electronic documents suitable for use in the refereeing process. The editorial office in Sweden will then be responsible for these manuscripts up to the final publication decision. Accepted articles will be sent to IOP for copy-editing, typesetting, production and distribution. We aim to provide our authors, referees and readers with an enhanced service for this well-established journal. IOP will maintain and augment Physica Scripta's record in publishing a broad range of high-quality research papers and we will continue to publish Topical Issues as supplements to the regular 12 issues. The popular Comments articles will continue to be published in conjunction with regular papers under this new partnership. We hope that our subscribers will continue to enjoy reading Physica Scripta as a valuable resource for general physics research.

  19. p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans.

    PubMed

    Wen, C; Greenwald, I

    1999-06-14

    Mutations in the Caenorhabditis elegans sel-9 gene elevate the activity of lin-12 and glp-1, which encode members of the LIN-12/NOTCH family of receptors. Sequence analysis indicates SEL-9 is one of several C. elegans p24 proteins. Allele-specific genetic interactions suggest that reducing sel-9 activity increases the activity of mutations altering the extracellular domains of LIN-12 or GLP-1. Reducing sel-9 activity restores the trafficking to the plasma membrane of a mutant GLP-1 protein that would otherwise accumulate within the cell. Our results suggest a role for SEL-9 and other p24 proteins in the negative regulation of transport of LIN-12 and GLP-1 to the cell surface, and favor a role for p24 proteins in a quality control mechanism for endoplasmic reticulum-Golgi transport. PMID:10366590

  20. CancerLinQ and the future of cancer care.

    PubMed

    Sledge, George W; Miller, Robert S; Hauser, Robert

    2013-01-01

    Patients, health care providers, and payers all have a similar interest in a health care system that is both efficient and intelligent. The attributes of such a system are widely recognized: we want a system that provides widespread access to consistently high-quality, science-based medical care; we want that system to be efficient, avoiding unnecessary waste, while delivering the right treatments to the right patients in a timely fashion; we want a system that allows us to both learn from our experience and generate new knowledge that will inform future treatment options; and we want a system that is compassionate and caring. What we want from a health care system often runs up against real-life obstacles and challenges: a fragmented delivery system, varying levels (or lack of) insurance, a growing burden of regulation and paperwork, and an increasingly complex understanding of tumor biology and the therapeutic approaches derived from this biology. New challenges are on the horizon-emerging genomic and imaging technology, with their enormous cognitive and data burdens, and a looming demographic challenge, where inadequate personnel resources face an aging population and an explosion of new treatments. Not all problems have technologic solutions, but many of the issues described above have potential solutions related to information technology. ASCO's CancerLinQ, described in this article, is an evolving attempt by the Society to improve the quality and efficiency of cancer care, while supporting education and research in the cancer field.

  1. CancerLinQ and the future of cancer care.

    PubMed

    Sledge, George W; Miller, Robert S; Hauser, Robert

    2013-01-01

    Patients, health care providers, and payers all have a similar interest in a health care system that is both efficient and intelligent. The attributes of such a system are widely recognized: we want a system that provides widespread access to consistently high-quality, science-based medical care; we want that system to be efficient, avoiding unnecessary waste, while delivering the right treatments to the right patients in a timely fashion; we want a system that allows us to both learn from our experience and generate new knowledge that will inform future treatment options; and we want a system that is compassionate and caring. What we want from a health care system often runs up against real-life obstacles and challenges: a fragmented delivery system, varying levels (or lack of) insurance, a growing burden of regulation and paperwork, and an increasingly complex understanding of tumor biology and the therapeutic approaches derived from this biology. New challenges are on the horizon-emerging genomic and imaging technology, with their enormous cognitive and data burdens, and a looming demographic challenge, where inadequate personnel resources face an aging population and an explosion of new treatments. Not all problems have technologic solutions, but many of the issues described above have potential solutions related to information technology. ASCO's CancerLinQ, described in this article, is an evolving attempt by the Society to improve the quality and efficiency of cancer care, while supporting education and research in the cancer field. PMID:23714566

  2. Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans

    PubMed Central

    Portegijs, Vincent; van Mourik, Tim; Akhmanova, Anna; Heck, Albert J. R.; van den Heuvel, Sander

    2016-01-01

    During cell division, the mitotic spindle segregates replicated chromosomes to opposite poles of the cell, while the position of the spindle determines the plane of cleavage. Spindle positioning and chromosome segregation depend on pulling forces on microtubules extending from the centrosomes to the cell cortex. Critical in pulling force generation is the cortical anchoring of cytoplasmic dynein by a conserved ternary complex of Gα, GPR-1/2, and LIN-5 proteins in C. elegans (Gα–LGN–NuMA in mammals). Previously, we showed that the polarity kinase PKC-3 phosphorylates LIN-5 to control spindle positioning in early C. elegans embryos. Here, we investigate whether additional LIN-5 phosphorylations regulate cortical pulling forces, making use of targeted alteration of in vivo phosphorylated residues by CRISPR/Cas9-mediated genetic engineering. Four distinct in vivo phosphorylated LIN-5 residues were found to have critical functions in spindle positioning. Two of these residues form part of a 30 amino acid binding site for GPR-1, which we identified by reverse two-hybrid screening. We provide evidence for a dual-kinase mechanism, involving GSK3 phosphorylation of S659 followed by phosphorylation of S662 by casein kinase 1. These LIN-5 phosphorylations promote LIN-5–GPR-1/2 interaction and contribute to cortical pulling forces. The other two critical residues, T168 and T181, form part of a cyclin-dependent kinase consensus site and are phosphorylated by CDK1-cyclin B in vitro. We applied a novel strategy to characterize early embryonic defects in lethal T168,T181 knockin substitution mutants, and provide evidence for sequential LIN-5 N-terminal phosphorylation and dephosphorylation in dynein recruitment. Our data support that phosphorylation of multiple LIN-5 domains by different kinases contributes to a mechanism for spatiotemporal control of spindle positioning and chromosome segregation. PMID:27711157

  3. LinA2, a HCH-converting bacterial enzyme that dehydrohalogenates HBCDs.

    PubMed

    Heeb, Norbert V; Wyss, Simon A; Geueke, Birgit; Fleischmann, Thomas; Kohler, Hans-Peter E; Lienemann, Peter

    2014-07-01

    Hexabromocyclododecanes (HBCDs) and hexachlorocyclohexanes (HCHs) are lipophilic, polyhalogenated hydrocarbons with comparable stereochemistry. Bacterial evolution in HCH-contaminated soils resulted in the development of several Spingomonadaceae which express a series of HCH-converting enzymes. We showed that LinB, a haloalkane dehalogenase from Sphingobium indicum B90A, also transforms various HBCDs besides HCHs. Here we present evidence that LinA2, another dehalogenase from S. indicum also converts certain HBCDs to pentabromocyclododecenes (PBCDEs). Racemic mixtures of α-, β-, γ-HBCDs, a mixture of them, and δ-HBCD, a meso form, were exposed to LinA2. Substantial conversion of (-)β-HBCD was observed, but all other stereoisomers were not transformed significantly. The enantiomeric excess (EE) of β-HBCDs increased up to 60% in 32 h, whereas EE values of α- and γ-HBCDs were not affected. Substrate conversion and product formation were described with second-order kinetic models. One major (P1β) and possibly two minor (P2β, P3β) metabolites were detected. Respective mass spectra showed the characteristic isotope pattern of PBCDEs, the HBr elimination products of HBCDs. Michaelis-Menten parameters KM=0.47 ± 0.07 μM and vmax=0.17 ± 0.01 μmoll(-1)h(-1) were deduced from exposure data with varying enzyme/substrate ratios. LinA2 is more substrate specific than LinB, the latter converted all tested HBCDs, LinA2 only one. The widespread HCH pollution favored the selection and evolution of bacteria converting these compounds. We found that LinA2 and LinB, two of these HCH-converting enzymes expressed in S. indicum B90A, also dehalogenate HBCDs to lower brominated compounds, indicating that structural similarities of both classes of compounds are recognized at the level of substrate-protein interactions. PMID:24444415

  4. Diabetes impairs mobilization of mouse bone marrow-derived Lin(-)/VEGF-R2(+) progenitor cells.

    PubMed

    Barthelmes, D; Irhimeh, M R; Gillies, M C; Karimipour, M; Zhou, M; Zhu, L; Shen, W Y

    2013-10-01

    Endothelial progenitor cells circulating in the peripheral blood (PB) contribute to vascular repair. This study aimed to evaluate the potential of a 'cocktail' consisting of erythropoietin, granulocyte colony-stimulating factor and tetrahydrobiopterin to mobilize hematopoietic lineage negative/vascular endothelial growth factor receptor 2 positive (Lin(-)/VEGF-R2(+)) cells from the bone marrow (BM) to PB in non-diabetic and diabetic mice. Diabetes was induced in mice by intraperitoneal injection of streptozotocin. Diabetic mice were studied after 16weeks of hyperglycemia. Half the mice in each group (non-diabetic and diabetic) received daily intraperitoneal injections of the cocktail for 6 consecutive days while the other half received vehicle buffer. Mobilization of Lin(-)/VEGF-R2(+) cells, which were expanded in MCP301 medium, was evaluated after isolating them from BM and PB and their phenotypic and morphological properties were studied. We found that 16weeks of diabetes affected neither the total number of BM mononucleated cells nor the number of Lin(-)/VEGF-R2(+) cells in BM compared with non-diabetic controls. In non-diabetic mice, cocktail treatment resulted in a significant decrease in BM Lin(-)/VEGF-R2(+) cells, paralleled by a significant increase of these cells in PB. Such changes in the number of Lin(-)/VEGF-R2(+) cells in BM and PB after the cocktail treatment were less marked in diabetic mice. In vitro studies of BM Lin(-)/VEGF-R2(+) cells from diabetic and non-diabetic mice did not reveal any differences in either phenotypes or colony forming potential. These findings indicate that diabetes impairs the mobilization of Lin(-)/VEGF-R2(+) cells from BM to PB. Impaired mobilization of BM Lin(-)/VEGF-R2(+) cells soon after the onset of diabetes may contribute to complications such as diabetic retinopathy.

  5. Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation.

    PubMed

    Tan, Shen Mynn; Altschuler, Gabriel; Zhao, Tian Yun; Ang, Haw Siang; Yang, Henry; Lim, Bing; Vardy, Leah; Hide, Winston; Thomson, Andrew M; Lareu, Ricky R

    2014-07-01

    LIN28 function is fundamental to the activity and behavior of human embryonic stem cells (hESCs) and induced pluripotent stem cells. Its main roles in these cell types are the regulation of translational efficiency and let-7 miRNA maturation. However, LIN28-associated mRNA cargo shifting and resultant regulation of translational efficiency upon the initiation of differentiation remain unknown. An RNA-immunoprecipitation and microarray analysis protocol, eRIP, that has high specificity and sensitivity was developed to test endogenous LIN28-associated mRNA cargo shifting. A combined eRIP and polysome analysis of early stage differentiation of hESCs with two distinct differentiation cues revealed close similarities between the dynamics of LIN28 association and translational modulation of genes involved in the Wnt signaling, cell cycle, RNA metabolism and proteasomal pathways. Our data demonstrate that change in translational efficiency is a major contributor to early stages of differentiation of hESCs, in which LIN28 plays a central role. This implies that eRIP analysis of LIN28-associated RNA cargoes may be used for rapid functional quality control of pluripotent stem cells under manufacture for therapeutic applications.

  6. Structure and Mechanism of the Lincosamide Antibiotic adenylyltransferase LinB

    SciTech Connect

    Morar, M.; Buhllar, K; Hughes, D; Junop, M; Wright, G

    2009-01-01

    Lincosamides make up an important class of antibiotics used against a wide range of pathogens, including methicillin-resistant Staphylococcus aureus. Predictably, lincosamide-resistant microorganisms have emerged with antibiotic modification as one of their major resistance strategies. Inactivating enzymes LinB/A catalyze adenylylation of the drug; however, little is known about their mechanistic and structural properties. We determined two X-ray structures of LinB: ternary substrate and binary productbound complexes. Structural and kinetic characterization of LinB, mutagenesis, solvent isotope effect, and product inhibition studies are consistent with a mechanism involving direct in-line nucleotidyl transfer. The characterization of LinB enabled its classification as a member of a nucleotidyltransferase superfamily, along with nucleotide polymerases and aminoglycoside nucleotidyltransferases, and this relationship offers further support for the LinB mechanism. The LinB structure provides an evolutionary link to ancient nucleotide polymerases and suggests that, like protein kinases and acetyltransferases, these are proto-resistance elements from which drug resistance can evolve.

  7. Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain

    PubMed Central

    Cuevas, Elisa; Rybak-Wolf, Agnieszka; Rohde, Anna M.; Nguyen, Duong T. T.; Wulczyn, F. Gregory

    2015-01-01

    Lin41/Trim71 is a heterochronic gene encoding a member of the Trim-NHL protein family, and is the original, genetically defined target of the microRNA let-7 in C. elegans. Both the LIN41 protein and multiple regulatory microRNA binding sites in the 3′ UTR of the mRNA are highly conserved from nematodes to humans. Functional studies have described essential roles for mouse LIN41 in embryonic stem cells, cellular reprogramming and the timing of embryonic neurogenesis. We have used a new gene trap mouse line deficient in Lin41 to characterize Lin41 expression during embryonic development and in the postnatal central nervous system (CNS). In the embryo, Lin41 is required for embryonic viability and neural tube closure. Nevertheless, neurosphere assays suggest that Lin41 is not required for adult neurogenesis. Instead, we show that Lin41 promoter activity and protein expression in the postnatal CNS is restricted to ependymal cells lining the walls of the four ventricles. We use ependymal cell culture to confirm reestablishment of Lin41 expression during differentiation of ependymal progenitors to post-mitotic cells possessing motile cilia. Our results reveal that terminally differentiated ependymal cells express Lin41, a gene to date associated with self-renewing stem cells. PMID:25883935

  8. EDITORIAL: Incoming Editor-in-Chief Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Birch, David

    2012-01-01

    It is a pleasure and an honour for me to be taking over as Editor-in-Chief of Measurement Science and Technology. MST is well known across research communities worldwide as a leading journal in which to publish new techniques and instrumentation. It has gained this enviable position largely because of the excellent guidance of its Editorial Board and dedicated staff at Institute of Physics Publishing over many years. I want to highlight in particular the contribution of the outgoing Editor Peter Hauptmann, and other Editors before him, in making the journal truly international. We thank Peter immensely for all his hard work in leading the journal, having exceptionally served two terms, each of five years. I come into the post of Editor at a very interesting and challenging time for research. The global recession is leading to cuts in research funding in many countries, researchers and their outputs are coming under closer scrutiny than ever before, and more is being expected of them. Journals play a critical role in monitoring and maintaining research standards, but we should be careful not to assume that journal Impact Factor is the sole measure of research quality. Although expediency may sometimes demand it, Impact Factor, as practitioners know, is subject dependent. One of the great things about science and technology for me is its level playing field. The key point is still innovation no matter where the work is done or where it is published. MST has a long pedigree of being the natural home of the highest quality papers from leading researchers wishing to report novel instrumentation and techniques. 2013 will mark the 90th anniversary of MST and we look forward to celebrating in style its sustained success. I recall with pride the first paper I published in Journal of Physics E: Scientific Instruments (as MST was previously titled) back in 1977. The paper reported the design and application of an early fluorescence lifetime spectrometer that I had constructed

  9. An Update: 1976 and 1987 Editors' Predictions of Audience Reactions to Videotex and A Comparison: 1987 Audience Reactions and 1976 and 1987 Editors' Predictions.

    ERIC Educational Resources Information Center

    Davenport, Lucinda D.

    To discover if editors' perceptions of audience opinions had changed and to determine the accuracy of editors' predictions regarding readers' reactions to using videotex, a 1987 study repeated a 1976 survey of Associated Press managing editors, and compared the responses with the original survey results. Surveys were sent to 302 Associated Press…

  10. Writing filter processes for the SAGA editor, appendix G

    NASA Technical Reports Server (NTRS)

    Kirslis, Peter A.

    1985-01-01

    The SAGA editor provides a mechanism by which separate processes can be invoked during an editing session to traverse portions of the parse tree being edited. These processes, termed filter processes, read, analyze, and possibly transform the parse tree, returning the result to the editor. By defining new commands with the editor's user defined command facility, which invoke filter processes, authors of filter can provide complex operations as simple commands. A tree plotter, pretty printer, and Pascal tree transformation program were already written using this facility. The filter processes are introduced, parse tree structure is described and the library interface made available to the programmer. Also discussed is how to compile and run filter processes. Examples are presented to illustrate aspect of each of these areas.

  11. SIRE: A Simple Interactive Rule Editor for NICBES

    NASA Technical Reports Server (NTRS)

    Bykat, Alex

    1988-01-01

    To support evolution of domain expertise, and its representation in an expert system knowledge base, a user-friendly rule base editor is mandatory. The Nickel Cadmium Battery Expert System (NICBES), a prototype of an expert system for the Hubble Space Telescope power storage management system, does not provide such an editor. In the following, a description of a Simple Interactive Rule Base Editor (SIRE) for NICBES is described. The SIRE provides a consistent internal representation of the NICBES knowledge base. It supports knowledge presentation and provides a user-friendly and code language independent medium for rule addition and modification. The SIRE is integrated with NICBES via an interface module. This module provides translation of the internal representation to Prolog-type rules (Horn clauses), latter rule assertion, and a simple mechanism for rule selection for its Prolog inference engine.

  12. νLIN6: An Integrated Mobility Protocol in IPv6

    NASA Astrophysics Data System (ADS)

    Banno, Ayumi; Teraoka, Fumio

    This paper proposes a protocol called νLIN6 which supports both network mobility and host mobility in IPv6. There are several proposals to support network mobility and host mobility. Network Mobility (NEMO) Basic Support Protocol has several problems such as pinball routing, large header overhead due to multiple levels of tunneling, and a single point of failure. Optimized NEMO (ONEMO) and Mobile IP with Address Translation (MAT) are solutions to provide route optimization, but they generate a lot of signaling messages at a handover. In νLIN6, packet relay is required only once regardless of the nested level in network mobility while optimal routing is always provided in host mobility. A fixedsized extension header is used in network mobility while there is no header overhead in host mobility. νLIN6 is more tolerant of network failure and mobility agent failure than NEMO Basic Support Protocol. It also allows ordinary IPv6 nodes to communicate with mobile nodes and nodes in the mobile network. We implemented νLIN6 on NetBSD 2.0 Release. Our measurement results showed νLIN6 can provide host mobility and network mobility with low overhead.

  13. Lin28-let7 Modulates Radiosensitivity of Human Cancer Cells With Activation of K-Ras

    SciTech Connect

    Oh, Jee-Sun.; Kim, Jae-Jin; Byun, Ju-Yeon; Kim, In-Ah

    2010-01-15

    Purpose: To evaluate the potential of targeting Lin28-let7 microRNA regulatory network for overcoming the radioresistance of cancer cells having activated K-Ras signaling. Methods and Materials: A549 lung carcinoma cells and ASPC1 pancreatic cancer cells possessing K-RAS mutation were transfected with pre-let7a microRNA or Lin28 siRNA, respectively. Clonogenic assay, quantitative reverse transcription polymerase chain reaction, and Western analysis were performed. The effects of Lin28 on SQ20B cells having wild-type K-RAS, and a normal fibroblast were also assessed. Results: The overexpression of let-7a decreased expression of K-Ras and radiosensitized A549 cells. Inhibition of Lin28, a repressor of let-7, attenuated K-Ras expression and radiosensitized A549 and ASPC1 cells. Neither SQ20B cells expressing wild-type K-RAS nor HDF, the normal human fibroblasts, were radiosensitized by this approach. Conclusions: The Lin28-let7 regulatory network may be a potentially useful therapeutic target for overcoming the radioresistance of human cancers having activated K-Ras signaling.

  14. Molecular basis for interaction of let-7 microRNAs with Lin28

    PubMed Central

    Nam, Yunsun; Chen, Casandra; Gregory, Richard I; Chou, James J; Sliz, Piotr

    2011-01-01

    SUMMARY MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. Among these, members of the let-7 miRNA family control many cell fate determination genes to influence pluripotency, differentiation, and transformation. Lin28 is a specific, post-transcriptional inhibitor of let-7 biogenesis. We report crystal structures of mouse Lin28 in complex with sequences from let-7d, let-7-f1, and let-7g precursors. The two folded domains of Lin28 recognize two distinct regions of the RNA and are sufficient for inhibition of let-7 in vivo. We also show by NMR spectroscopy that the linker connecting the two folded domains is flexible, accommodating Lin28 binding to diverse let-7 family members. Protein-RNA complex formation imposes specific conformations on both components that could affect downstream recognition by other processing factors. Our data provide a molecular explanation for Lin28 specificity and a model for how it regulates let-7. PMID:22078496

  15. EDITORIAL: New Editor-in-Chief for Nanotechnology New Editor-in-Chief for Nanotechnology

    NASA Astrophysics Data System (ADS)

    Couzin, Nina

    2009-01-01

    Nanotechnology is proud to announce the appointment of Professor Mark Reed, Yale University, as the new Editor-in-Chief from January 2009. Mark Reed holds the Harold Hodgkinson Chair of Engineering and Applied Science at Yale University. He has made significant contributions in the areas of quantum dots, electronic transport in nanoscale and mesoscopic systems, artificially structured materials and devices, and molecular electronics. Professor Reed has been associated with the journal as an Editorial Board member for a number of years and we are delighted that he has agreed to take on the scientific leadership of the journal in its 20th year. We also take the opportunity to thank Professor Mark Welland, Cambridge University, for his work as Editor-in-Chief since 2001, and for presiding over the re-launch and remarkable growth of the journal since then. Nanotechnology is unique in that it was the first peer-reviewed journal in the area of nanoscience, the first issue appearing in 1990. Since then it has established a distinguished publication record and has become a leading journal covering all aspects of nanoscale science and technology, as well as specializing in in-depth, comprehensive articles not seen in letter format journals. Published weekly and featuring subject sections, the journal is truly multidisciplinary in nature and is an excellent medium to quickly deliver your research results to readers worldwide. Nanotechnology is proud to be offering some of the fastest publication times around (less than three months on average from receipt to online publication). We offer free online access to all published papers for 30 days, ensuring that anyone with access to the internet will be able to read your paper. We were also the first journal to give our authors the opportunity to communicate their research to a wider audience through nanotechweb.org and other IOP websites. See the journal's homepage at www.iop.org/Journals/nano for more details. We are looking

  16. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    NASA Astrophysics Data System (ADS)

    Cardona, Manuel

    2005-02-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  17. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    NASA Astrophysics Data System (ADS)

    Cardona, Manuel

    2005-03-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  18. Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors

    PubMed Central

    Desjardins, Alexandre; Bouvette, Jonathan; Legault, Pascale

    2014-01-01

    Lin28 inhibits the biogenesis of let-7 miRNAs through direct interactions with let-7 precursors. Previous studies have described seemingly inconsistent Lin28 binding sites on pre-let-7 RNAs. Here, we reconcile these data by examining the binding mechanism of Lin28 to the terminal loop of pre-let-7g (TL-let-7g) using biochemical and biophysical methods. First, we investigate Lin28 binding to TL-let-7g variants and short RNA fragments and identify three independent binding sites for Lin28 on TL-let-7g. We then determine that Lin28 assembles in a stepwise manner on TL-let-7g to form a stable 1:3 complex. We show that the cold-shock domain (CSD) of Lin28 is responsible for remodelling the terminal loop of TL-let-7g, whereas the NCp7-like domain facilitates the initial binding of Lin28 to TL-let-7g. This stable binding of multiple Lin28 molecules to the terminal loop of pre-let-7g extends to other precursors of the let-7 family, but not to other pre-miRNAs tested. We propose a model for stepwise assembly of the 1:1, 1:2 and 1:3 pre-let-7g/Lin28 complexes. Stepwise multimerization of Lin28 on pre-let-7 is required for maximum inhibition of Dicer cleavage for a least one member of the let-7 family and may be important for orchestrating the activity of the several factors that regulate let-7 biogenesis. PMID:24452802

  19. Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway

    PubMed Central

    Joshua-Tor, Leemor

    2014-01-01

    Summary paragraph The pluripotency factor Lin28 inhibits the biogenesis of the let-7 family of mammalian microRNAs1–4. Lin28 is highly expressed in embryonic stem cells and has a fundamental role in regulation of development5, glucose metabolism6 and tissue regeneration7. Alternatively, Lin28 overexpression is correlated with the onset of numerous cancers8, while let-7, a tumor suppressor, silences several human oncogenes5. Lin28 binds to precursor let-7 (pre-let-7) hairpins9, triggering the 3' oligo-uridylation activity of TUT4/710–12. The oligoU tail added to pre-let-7 serves as a decay signal, as it is rapidly degraded by Dis3L213,14, a homolog of the catalytic subunit of the RNA exosome. The molecular basis of Lin28 mediated recruitment of TUT4/7 to pre-let-7 and its subsequent degradation by Dis3L2 is largely unknown. To examine the mechanism of Dis3L2 substrate recognition we determined the structure of mouse Dis3L2 in complex with an oligoU RNA to mimic the uridylated tail of pre-let-7. Three RNA binding domains form an open funnel on one face of the catalytic domain that allows RNA to navigate a path to the active site different from its exosome counterpart. The resulting path reveals an extensive network of uracil-specific interactions spanning the first twelve nucleotides of an oligoU-tailed RNA. We identify three U-specificity zones that explain how Dis3L2 recognizes, binds and processes uridylated pre-let-7 in the final step of the Lin28/let-7 pathway. PMID:25119025

  20. Most Business Editors Find Journalism Graduates Still Unprepared

    ERIC Educational Resources Information Center

    Pardue, Mary Jane

    2014-01-01

    In 2002, a study was published in "Newspaper Research Journal" that explored the preparedness of graduating journalism students to cover business news. In 2012, a follow-up survey of business editors at the nation's daily newspapers was done to see whether progress had been made in the training of journalism students for the…

  1. Developing and Presenting Auditory Demonstrations: Two Sound Editor Programs

    ERIC Educational Resources Information Center

    Firment, Michael J.

    2006-01-01

    Experiencing examples of auditory phenomena can clarify textbook and lecture explanations. The addition of visual displays to auditory demonstrations can make them more understandable. Two sound editor programs, Audacity[R] and Adobe Audition Pro 2.0[R], provide excellent capabilities for the display and authoring of auditory demonstrations.…

  2. Publishing in Educational Psychology Journals: Comments from Editors

    ERIC Educational Resources Information Center

    Nihalani, Priya K.; Mayrath, Michael C.

    2008-01-01

    The following paper emphasizes the importance of publishing and learning how to publish in educational psychology journals. We have compiled a set of recommendations based on advice from editors in the field and several other sources on how to publish. Additionally, this paper provides a step-by-step guide that graduate students and junior faculty…

  3. Particle size fraction -Response: Letter to the Editors

    EPA Science Inventory

    To the Editors: We, the undersigned, would like to comment on the article by Cho et al. (Cho et al. 2009), which was published in the November 2009 issue (volume 11, number 11, page 1682-1689) of Environmental Health Perspectives. We read the paper with great interest as the dis...

  4. The Editor and the Fund Raiser: Partners or Adversaries?

    ERIC Educational Resources Information Center

    Collins, Walt; Hincker, Lawrence; Yoe, Mary Ruth; Loyless, Darrell

    1999-01-01

    In a panel format, experienced college publications editors and development professionals discussed their responses to three scenarios describing clashes between alumni magazine staff and development officers: writing donor profiles; reporting negative campus news; and publishing campaign materials in the alumni magazine. Excerpts of the…

  5. Help Students to Be Skillful Editors. Ready to Write.

    ERIC Educational Resources Information Center

    Avery, Carol

    1993-01-01

    Elementary students can become good editors by using editing skills during the writing process. Teachers must present and repeat editing topics in minilessons, provide reminders of particular skills that were addressed, teach students to use editing resources, and expect students to develop proper usage gradually. (SM)

  6. Advice for a young editor: my journey in dental journalism.

    PubMed

    Curtis, Eric K

    2005-01-01

    Editing is sometimes a good route to writing; it may certainly be useful for an editor to understand the writer's point of view. Tips are offered regarding building writing skills, developing personal discipline, and generating story ideas. Writing and editing can be a way of finding out who one is.

  7. LETTER TO EDITOR ON ARTICLE "ARSENIC MEANS BUSINESS"

    EPA Science Inventory

    The letter to the editor was written to point out that different forms of arsenic are found in source waters and that the technologies listed in the article such as POU RO will not necessarily be effective on all waters. The letter pointed out that most technologies are more eff...

  8. Using a Computerized Text-Editor in Freshman Composition.

    ERIC Educational Resources Information Center

    Gerrard, Lisa

    To determine how useful a computerized text editor would be in helping students to revise their papers, an interactive text manipulation system (Wylbur) was made available to two classes of freshman composition students at the University of California, Los Angeles. Since the course received no advance publicity, students did not know when they…

  9. IN DEFENSE OF ECORISK ASSESSMENT (LETTER TO EDITOR)

    EPA Science Inventory

    Dear Editor: We are writing to convey a more accurate portrayal of the status of ecological ("environmental" in Europe) risk assessment that was presented in the recent article by M. Power and L.S. McCarty (Fallacies in Ecological Risk Assessment Practices," August 1997, pp 370A-...

  10. September 2016 Letter to the Editor-in-Chief.

    PubMed

    2016-09-01

    Letter to the Editor-in-Chief of JOSPT as follows: "One More Cause of Failure to Validate a CPR: Overfitting" with Author's Response J Orthop Sports Phys Ther 2016;46(9):811-812. doi:10.2519/jospt.2016.0202. PMID:27581182

  11. An Editor's View of the State of Applied Developmental Psychology.

    ERIC Educational Resources Information Center

    Cocking, Rodney R.

    Addressed are issues and problems of definition that arose in establishing a new scientific journal. Specifically, the problems considered are those confronting the "Journal of Applied Developmental Psychology" (JADP) in its first 5 years of existence. The first matter of definition discussed is the editor's role. Ways in which editorial power was…

  12. Cytogenetically aberrant cells in the stem cell compartment (CD34+lin-) in acute myeloid leukemia.

    PubMed

    Mehrotra, B; George, T I; Kavanau, K; Avet-Loiseau, H; Moore, D; Willman, C L; Slovak, M L; Atwater, S; Head, D R; Pallavicini, M G

    1995-08-01

    Leukemia may be viewed as a clonal expansion of blast cells; however, the role of primitive cells and/or stem cells in disease etiology and progression is unclear. We investigated stem cell involvement in leukemia using fluorescence in situ hybridization (FISH), immunofluorescence labeling of hematopoietic subpopulations, and flow cytometric analysis/sorting to discriminate and quantify cytogenetically aberrant stem cells in 12 acute myeloid leukemia (AML) and three myelodysplastic (MDS) specimens. Flow cytometric analysis and sorting were used to discriminate and collect a primitive subpopulation enriched in stem cells expressing CD34+ and lacking CD33 and CD38 (CD34+lin-). A subpopulation containing progenitors and differentiating myeloid cells expressed CD34, CD33, and CD38 (CD34+lin+). Nine specimens contained less than 10% CD34+ cells and, thus, were considered to be CD34- leukemias. Mature lymphoid, myeloid, and erythroid subpopulations were sorted on the basis of antigen-linked immunofluorescence. Cytogenetically aberrant cells in sorted subpopulations were identified using FISH with enumerator probes selected on the basis of diagnosis karyotype. Cytogenetically aberrant CD34+lin- cells were present at frequencies between 9% and 99% in all specimens. CD34+lin- cytogenetically aberrant cells comprised between 0.05% and 11.9% of the marrow/blood specimens. Cytogenetically aberrant CD34+lin+ cells constituted 0.01% tp 56% of the marrow/blood population. These data demonstrate that aberrant cells are present in primitive CD34+ stem cell compartments, even in CD34- leukemias. Stem cell involvement was confirmed further by sorting lymphoid and erythroid subpopulations from eight specimens in which the predominant leukemic population lacked lymphoid/erythroid differentiation markers. In these specimens, as well as in multiple lineages, suggests involvement of a cell(s) with multilineage capabilities. The ability of aberrant CD34+lin- stem cells to contribute to

  13. Decreased Lin7b Expression in Layer 5 Pyramidal Neurons May Contribute to Impaired Corticostriatal Connectivity in Huntington Disease

    PubMed Central

    Zucker, Birgit; Kama, Jibrin A.; Kuhn, Alexandre; Thu, Doris; Orlando, Lianna R.; Dunah, Anthone W.; Gokce, Ozgun; Taylor, David M.; Lambeck, Johann; Friedrich, Bernd; Lindenberg, Katrin S.; Faull, Richard L.M.; Weiller, Cornelius; Young, Anne B.; Luthi-Carter, Ruth

    2010-01-01

    Motor dysfunction, cognitive impairment and regional cortical atrophy indicate cerebral cortical involvement in Huntington disease (HD). To address the hypothesis that abnormal corticostriatal connectivity arises from polyglutamine-related alterations in cortical gene expression, we isolated layer 5 cortical neurons by laser-capture microdissection and analyzed transcriptome-wide mRNA changes in them. Enrichment of transcription factor mRNAs including foxp2, tbr1, and neuroD6, and neurotransmission- and plasticity-related RNAs including sema5A, pclo, ntrk2, cntn1 and lin7b were observed. Layer 5 motor cortex neurons of transgenic R6/2 HD mice also demonstrated numerous transcriptomic changes, including decreased expression of mRNAs encoding the lin7 homolog b, (lin7b, also known as veli-2 and mals2). Decreases in LIN7B and CNTN1 RNAs were also detected in human HD layer 5 motor cortex neurons. lin7b, a scaffold protein implicated in synaptic plasticity, neurite outgrowth and cellular polarity, was decreased at the protein level in layer 5 cortical neurons in R6/2 mice and human HD brains. Decreases in Lin7b and Lin7a mRNAs were detected in R6/2 cortex as early as 6 weeks of age, suggesting that this is an early pathogenetic event. Thus, decreased cortical LIN7 expression may contribute to abnormal corticostriatal connectivity in HD. PMID:20720508

  14. Kinetic and Sequence-Structure-Function Analysis of Known LinA Variants with Different Hexachlorocyclohexane Isomers

    PubMed Central

    Kumari, Kirti; Pandey, Gunjan; Jackson, Colin J.; Russell, Robyn J.; Oakeshott, John G.; Lal, Rup

    2011-01-01

    Background Here we report specific activities of all seven naturally occurring LinA variants towards three different isomers, α, γ and δ, of a priority persistent pollutant, hexachlorocyclohexane (HCH). Sequence-structure-function differences contributing to the differences in their stereospecificity for α-, γ-, and δ-HCH and enantiospecificity for (+)- and (−)-α -HCH are also discussed. Methodology/Principal Findings Enzyme kinetic studies were performed with purified LinA variants. Models of LinA2B90A A110T, A111C, A110T/A111C and LinA1B90A were constructed using the FoldX computer algorithm. Turnover rates (min−1) showed that the LinAs exhibited differential substrate affinity amongst the four HCH isomers tested. α-HCH was found to be the most preferred substrate by all LinA's, followed by the γ and then δ isomer. Conclusions/Significance The kinetic observations suggest that LinA-γ1-7 is the best variant for developing an enzyme-based bioremediation technology for HCH. The majority of the sequence variation in the various linA genes that have been isolated is not neutral, but alters the enantio- and stereoselectivity of the encoded proteins. PMID:21949868

  15. Editor and authors' psychology and the chance of teaching.

    PubMed

    Grammaticos, Philip C

    2006-01-01

    It is the duty of the editor to communicate with the authors who submit their scientific work for publication. The question arises as to the best way to perform this communication. The goal is to publish papers that would make their authors proud and the readers of the journal, satisfied. This goal is expressed with honesty, kindness, politeness, diplomacy and when the editor communicated with authors from other Countries, the advice of a person familiar with the traditions of these Countries may be welcome. The unpleasant editor's duty to inform the authors of their paper being rejected, can be expressed either by writing a brief straight forward letter or by giving a more detailed answer or finally, by explaining to the authors their errors in a detailed manner, in other words, by giving them advice and consultation. In his reply to the authors whose paper has been rejected, the editor may touch a sensitive part of their behavior. Authors may consider their paper as "their intellectual child". Some times authors make unacceptable mistakes that may or may not be revealed by the reviewers. Explaining in detail errors and thus counseling the authors, is hard work for the editor but not always appreciated by the authors. The value of counseling and teaching has been emphasized even by ancient philosophers but nowadays enthusiasm in learning is sometimes lacking. Is there a solution to the above? Perhaps if "the instructions to authors" of a journal specified clearly the "submission terms" for accepting a paper for publication, then the authors could be self-evaluated and perhaps all parties concerned would be happier.

  16. EDITORIAL: Outgoing Editor-in-Chief Outgoing Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2012-01-01

    I started in 2002 as Editor-in-Chief of a well established journal—MST (Measurement Science and Technology). It was a time when modern means of communication offered new opportunities for the scientific community—for all scientists and engineers whether at universities, in industry or at other institutions—to access better quality information in a shorter time. This development helped us to be more efficient in our daily scientific work and to anticipate new trends faster than before. A flood of information was created by different search engines. A few online journals or journals published in emerging countries with a similar profile to MST appeared on the market. MST had to provide new answers in response to these developments. In 2002 I postulated two requirements to the journal. Firstly, the publisher has to be up to date. My impression over the years has been that IOPP is excellently organized. That has made it easier for the board members and all our reviewers to concentrate on the scientific aspects of our input to the journal. During all my visits to Bristol or my contacts with the IOPP staff I always met very professional and enthusiastic staff members. They have not only supported and encouraged the ideas and initiatives of the Editorial Board members, but they have also worked hard on establishing one of the most effective journal operations in the field of measurement science and technology. Many authors are well aware of this. Thus I am able to declare that the first requirement for a successful journal has been met. Secondly, the scientific level has to be high and the journal should attract readers from all over the world. This task was the responsibility of the Editorial Board members and of myself. Our strategy was on the one hand to ensure continuity in MST but on the other hand to be open to new trends and developments. Examples of these new aspects of the journal are fields like micro- and nanometrology, measurement techniques for

  17. Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator.

    PubMed

    Leight, Elizabeth R; Murphy, John T; Fantz, Douglas A; Pepin, Danielle; Schneider, Daniel L; Ratliff, Thomas M; Mohammad, Duaa H; Herman, Michael A; Kornfeld, Kerry

    2015-03-01

    The LIN-1 ETS transcription factor plays a pivotal role in controlling cell fate decisions during development of the Caenorhabditis elegans vulva. Prior to activation of the RTK/Ras/ERK-signaling pathway, LIN-1 functions as a SUMOylated transcriptional repressor that inhibits vulval cell fate. Here we demonstrate using the yeast two-hybrid system that SUMOylation of LIN-1 mediates interactions with a protein predicted to be involved in transcriptional repression: the RAD-26 Mi-2β/CHD4 component of the nucleosome remodeling and histone deacetylation (NuRD) transcriptional repression complex. Genetic studies indicated that rad-26 functions to inhibit vulval cell fates in worms. Using the yeast two-hybrid system, we showed that the EGL-27/MTA1 component of the NuRD complex binds the carboxy-terminus of LIN-1 independently of LIN-1 SUMOylation. EGL-27 also binds UBC-9, an enzyme involved in SUMOylation, and MEP-1, a zinc-finger protein previously shown to bind LIN-1. Genetic studies indicate that egl-27 inhibits vulval cell fates in worms. These results suggest that LIN-1 recruits multiple proteins that repress transcription via both the SUMOylated amino-terminus and the unSUMOylated carboxy-terminus. Assays in cultured cells showed that the carboxy-terminus of LIN-1 was converted to a potent transcriptional activator in response to active ERK. We propose a model in which LIN-1 recruits multiple transcriptional repressors to inhibit the 1° vulval cell fate, and phosphorylation by ERK converts LIN-1 to a transcriptional activator that promotes the 1° vulval cell fate.

  18. How Do Washington's Newspaper Editors Evaluate Their Sources of Agricultural News?--A Survey.

    ERIC Educational Resources Information Center

    Sampson, M. W.

    This report presents the results of a questionnaire sent to the daily and weekly newspaper editors in Washington to evaluate their sources of agricultural news. Responses were obtained from 16 of 21 daily newspaper editors queried and 63 of 140 weekly editors. The questionnaire was designed to check the accuracy of newspapers' mailing addresses,…

  19. FLAn: A Free Hypermedia Editor to Create Foreign Language Learning Units

    ERIC Educational Resources Information Center

    Kilickaya, Ferit, Ed.

    2011-01-01

    Glossing words is done via special software called multimedia editors. Foreign Language Annotator (FLAn), created by Thibeault (2011), is one of these multimedia editors. FLAn (Foreign Language Annotator), a free hypermedia editor that works on both Macs and PCs, allows instructors to turn static texts into dynamic learning units by attaching…

  20. Extension of Lin empirical formula for the prediction of rain attenuation

    NASA Astrophysics Data System (ADS)

    Kanellopoulos, J. D.

    1983-04-01

    Lin's empirical expression for calculating rain attenuation is applicable to 5-min point rain rate distributions. A modification of this empirical formula is presented, for application to rain rate with arbitrary integration time. The applicability of this technique is tested against experimental data taken from several locations in the United States and western Europe.

  1. LinAir: A multi-element discrete vortex Weissinger aerodynamic prediction method

    NASA Technical Reports Server (NTRS)

    Durston, Donald A.

    1993-01-01

    LinAir is a vortex lattice aerodynamic prediction method similar to Weissinger's extended lifting-line theory, except that the circulation around a wing is represented by discrete horseshoe vortices, not a continuous distribution of vorticity. The program calculates subsonic longitudinal and lateral/directional aerodynamic forces and moments for arbitrary aircraft geometries. It was originally written by Dr. Ilan Kroo of Stanford University, and subsequently modified by the author to simplify modeling of complex configurations. The Polhamus leading-edge suction analogy was added by the author to extend the range of applicability of LinAir to low aspect ratio (i.e., fighter-type) configurations. A brief discussion of the theory of LinAir is presented, and details on how to run the program are given along with some comparisons with experimental data to validate the code. Example input and output files are given in the appendices to aid in understanding the program and its use. This version of LinAir runs in the VAX/VMS, Cray UNICOS, and Silicon Graphics Iris workstation environments at the time of this writing.

  2. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion

    PubMed Central

    Chakraborty, P; Buaas, F.W.; Sharma, M; Snyder, E; de Rooij, D.G.; Braun, R.E.

    2014-01-01

    One of the hallmarks of highly proliferative adult tissues is the presence of a stem cell population that produces progenitor cells bound for differentiation. Progenitor cells undergo multiple transit amplifying (TA) divisions before initiating terminal differentiation. In the adult male germline, daughter cells arising from the spermatogonial stem cells (SSCs) undergo multiple rounds of TA divisions to produce undifferentiated clones of interconnected 2, 4, 8 and 16 cells, collectively termed Aundifferentiated (Aundiff) spermatogonia, before entering a stereotypic differentiation cascade. Although the number of TA divisions markedly affects the tissue output both at steady state and during regeneration, mechanisms regulating the expansion of the TA cell population are poorly understood in mammals. Here, we show that mice with a conditional deletion of Lin28a in the adult male germline, display impaired clonal expansion of the progenitor transit amplifying Aundiff spermatogonia. The in vivo proliferative activity of Aundiff spermatogonial cells as indicated by BrdU incorporation during S phase was reduced in the absence of LIN28A. Thus contrary to the role of LIN28A as a key determinant of cell fate signals in multiple stem cell lineages, in the adult male germline it functions as an intrinsic regulator of proliferation in the population of Aundiff TA spermatogonia. In addition, neither precocious differentiation nor diminished capacity for self-renewal potential as assessed by transplantation was observed, suggesting that neither LIN28A itself, nor the pool of Aal progenitor cells, substantially contribute to the functional stem cell compartment. PMID:24715688

  3. The Value of SCMC in SLA: Comments on Lin, Huang & Liou (2013)

    ERIC Educational Resources Information Center

    Taylor, Alan M.

    2014-01-01

    Meta-analytic methods are often used to determine the effectiveness of certain treatments across studies. However, we are often unaware of how a meta-analysis can provide value to researchers and practitioners. This paper offers a brief commentary on a meta-analysis conducted by Lin, Huang and Liou (2013) in LLT, providing further statistical…

  4. The Lin28/let-7 axis is critical for myelination in the peripheral nervous system

    PubMed Central

    Gökbuget, Deniz; Pereira, Jorge A.; Bachofner, Sven; Marchais, Antonin; Ciaudo, Constance; Stoffel, Markus; Schulte, Johannes H.; Suter, Ueli

    2015-01-01

    MicroRNAs (miRNAs) are crucial regulators of myelination in the peripheral nervous system (PNS). However, the miRNAs species involved and the underlying mechanisms are largely unknown. We found that let-7 miRNAs are highly abundant during PNS myelination and that their levels are inversely correlated to the expression of lin28 homolog B (Lin28B), an antagonist of let-7 accumulation. Sustained expression of Lin28B and consequently reduced levels of let-7 miRNAs results in a failure of Schwann cell myelination in transgenic mouse models and in cell culture. Subsequent analyses revealed that let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20 (also known as Egr2) through suppression of myelination inhibitory Notch signalling. We conclude that the Lin28B/let-7 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases. PMID:26466203

  5. The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.

    PubMed

    Gökbuget, Deniz; Pereira, Jorge A; Bachofner, Sven; Marchais, Antonin; Ciaudo, Constance; Stoffel, Markus; Schulte, Johannes H; Suter, Ueli

    2015-10-14

    MicroRNAs (miRNAs) are crucial regulators of myelination in the peripheral nervous system (PNS). However, the miRNAs species involved and the underlying mechanisms are largely unknown. We found that let-7 miRNAs are highly abundant during PNS myelination and that their levels are inversely correlated to the expression of lin28 homolog B (Lin28B), an antagonist of let-7 accumulation. Sustained expression of Lin28B and consequently reduced levels of let-7 miRNAs results in a failure of Schwann cell myelination in transgenic mouse models and in cell culture. Subsequent analyses revealed that let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20 (also known as Egr2) through suppression of myelination inhibitory Notch signalling. We conclude that the Lin28B/let-7 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases.

  6. PREFACE: Introductory remarks from the Editors Introductory remarks from the Editors

    NASA Astrophysics Data System (ADS)

    Knobloch, E.; Meseguer, A.; Marques, F.

    2012-06-01

    The local organizers of the 4th BIFD (Bifurcations and Instabilities in Fluid Dynamics) Symposium held in Barcelona on 18-21 July 2011 would like to thank the editors of Fluid Dynamics Research for offering us the opportunity of publishing a peer-reviewed special issue of the journal with a selection of the contributions presented at this conference. We thank both the authors and the referees for working with us on the rather tight schedule necessary to release the issue within one year of the date of the conference. We also thank the invited speakers, B Eckhardt, L Tuckerman, and J M Vega, for contributing keynote papers to this special issue. The series of BIFD symposia started as a small workshop in Madeira, Portugal, in 2004 with no more than 20 participants. This number increased rapidly during the second and third symposia held in 2006 (Denmark) and 2009 (United Kingdom), with 40 and 110 participants, respectively. The 4th BIFD symposium has consolidated this event as one of the leading conferences in hydrodynamic stability, with nearly 200 participants from around the world. The main goal of this conference is to bring together scientists and engineers from different disciplines directly or indirectly related to fluid dynamics, bifurcation theory and hydrodynamic stability theory. The conference covered many research areas within the aforementioned fields, ranging from thermal, shear and centrifugal flows to biofluids, films, drops, viscoelastic flows and magnetohydrodynamics. The structure of the conference, with invited plenary talks and focused sessions, helped the participants find their home in the conference and share state-of-the-art knowledge within the field of hydrodynamic instabilities. The financial support from MICINN (Spanish Ministry of Science and Innovation, Grant no FIS2009-08065-E) and UPC (Universitat Politècnica de Catalunya) is greatly appreciated. The local organizers would also like to thank ETSAB (Barcelona School of Architecture

  7. Aire promotes the self-renewal of embryonic stem cells through Lin28.

    PubMed

    Bin, Gu; Jiarong, Zhang; Shihao, Wang; Xiuli, Song; Cheng, Xu; Liangbiao, Chen; Ming, Zhang

    2012-10-10

    Abstract Autoimmune regulator (Aire) is one of the most well-characterized molecules in autoimmunity, but its function outside the immune system is largely unknown. The recent discovery of Aire expression in stem cells and early embryonic cells and its function in the self-renewal of embryonic stem (ES) cells highlight the importance of Aire in these cells. In this study, we present evidence that Aire promotes the expression of the pluripotent factor Lin28 and the self-renewal of ES cells. We presented the first evidence that the let-7 microRNA family contributed to the self-renewal promoting effect of Aire on ES cells. Moreover, we showed that Aire and Lin28 are co-expressed in the genital ridge, oocytes, and cleavage-stage embryos, and the expression level of Lin28 is correlated with the expression level of Aire. Although it is widely considered to be a promiscuous gene expression activator, these results indicated that Aire promotes the self-renewal of ES cells through a specific pathway (i.e., the activation of Lin28 and the inhibition of the let-7 microRNA family). The correlation between Aire and Lin28 expression in germ cells and early embryos indicated an in vivo function for Aire in toti- and pluripotent stem cells. This study presents the first molecular pathway that incorporates Aire into the pluripotency network. Moreover, it presents the first evidence that microRNAs contribute to the regulatory function of Aire and highlights a novel function of Aire in stem cell biology and reproduction. These functions reveal novel perspectives for studying the molecular mechanisms behind the establishment and sustenance of pluripotent identity.

  8. LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia.

    PubMed

    Helsmoortel, Hetty H; Bresolin, Silvia; Lammens, Tim; Cavé, Hélène; Noellke, Peter; Caye, Aurélie; Ghazavi, Farzaneh; de Vries, Andrica; Hasle, Henrik; Labarque, Veerle; Masetti, Riccardo; Stary, Jan; van den Heuvel-Eibrink, Marry M; Philippé, Jan; Van Roy, Nadine; Benoit, Yves; Speleman, Frank; Niemeyer, Charlotte; Flotho, Christian; Basso, Giuseppe; Te Kronnie, Geertruy; Van Vlierberghe, Pieter; De Moerloose, Barbara

    2016-03-01

    Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive stem cell disease of early childhood. RAS activation constitutes the core component of oncogenic signaling. In addition, leukemic blasts in one-fourth of JMML patients present with monosomy 7, and more than half of patients show elevated age-adjusted fetal hemoglobin (HbF) levels. Hematopoietic stem cell transplantation is the current standard of care and results in an event-free survival rate of 50% to 60%, indicating that novel molecular-driven therapeutic options are urgently needed. Using gene expression profiling in a series of 82 patient samples, we aimed at understanding the molecular biology behind JMML and identified a previously unrecognized molecular subgroup characterized by high LIN28B expression. LIN28B overexpression was significantly correlated with higher HbF levels, whereas patients with monosomy 7 seldom showed enhanced LIN28B expression. This finding gives a biological explanation of why patients with monosomy 7 are rarely diagnosed with high age-adjusted HbF levels. In addition, this new fetal-like JMML subgroup presented with reduced levels of most members of the let-7 microRNA family and showed characteristic overexpression of genes involved in fetal hematopoiesis and stem cell self-renewal. Lastly, high LIN28B expression was associated with poor clinical outcome in our JMML patient series but was not independent from other prognostic factors such as age and age-adjusted HbF levels. In conclusion, we identified elevated LIN28B expression as a hallmark of a novel fetal-like subgroup in JMML. PMID:26712910

  9. From the desk of the Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Hei, Tom K.

    2015-07-01

    Life Sciences in Space Research had a prominent presence at the International Congress of Radiation Research (ICRR) meeting held in Kyoto, Japan from May 25th-29th, with seven of the eleven editors attending the meeting. A journal booth was also put up at the pre-ICRR satellite meeting on Space Radiation and Heavy Ions in Therapy (SRHITS) held a few days earlier in Osaka. Since the inception of LSSR last year, the editors and publisher have promoted the journal at a number of major conferences including COSPAR 2014 in Moscow, the annual meeting of the Radiation Research Society and the NASA Space Radiation Investigators Meeting. These efforts have increased awareness of the journal among investigators in space life sciences and related fields. The number of monthly downloads of articles from the journal website averages 2000, a respectable number for a brand new journal.

  10. The Digital Audio Editor as a Teaching and Laboratory Tool

    NASA Astrophysics Data System (ADS)

    Latta, Gregory

    2001-10-01

    Digital audio editors such as Software Audio Workshop and Cool Edit Pro are powerful tools used in the radio and audio recording fields for editing digital audio. However, they are also powerful tools in the physics classroom and laboratory. During this presentation the author will show how a digital audio editor, combined with a library of audio .wav files produced by the author as part of sabbatical work, can be used to: 1. demonstrate quantitatively and qualitatively the relationship between the decibel, sound intensity, and loudness perception, 2. demonstrate quantitatively and qualitatively the relationship between frequency and pitch perception, 3. perform additive and subtractive sound synthesis, 4. demonstrate comb filtering, 5. demonstrate constructive and destructive interference, and 6. turn the computer into an accurate signal generator (sine wave, square wave, etc.) with a frequency resolution of 1Hz. Availability of the required software and .wav file library will also be discussed.

  11. William E. Edmonston, Jr.: Editor, 1968-1976.

    PubMed

    Kihlstrom, John F; Frischholz, Edward J

    2010-10-01

    This article is part of an occasional series profiling editors of the American Journal of Clinical Hypnosis (AJCH). William E. Edmonston was the second editor, succeeding Milton H. Erickson. His research focused on the use of conditioning paradigms and psychophysiological measures to explore a wide variety of hypnotic phenomena, leading to a "neo-Pavlovian" theory of neutral hypnosis as physiological relaxation (anesis). A longtime professor of psychology at Colgate University, he created an interdisciplinary undergraduate major in neuroscience, and was named New York State College Professor of the Year in 1988. He gave the Journal a new look, and a greater balance of clinical and experimental papers. The article also provides background on George Barton Cutten, George H. Estabrooks, and Frank A. Pattie, pioneers of hypnosis who were linked to Edmonston.

  12. Reference Accuracy: Authors', Reviewers', Editors', and Publishers' Contributions

    PubMed Central

    2014-01-01

    Scientific authors are responsible for the accuracy of their writings and references to others' works. However, relying on authors is not enough when it comes to processing their manuscripts. Joint efforts of authors, peer reviewers, editors, and publishers throughout the publishing process may prevent most reference errors. This article analyzes essential aspects of bibliographic management and focuses on the importance of validating references by all stakeholders of scholarly publishing. PMID:25469055

  13. Towards a document structure editor for software requirements analysis

    NASA Technical Reports Server (NTRS)

    Kowalski, Vincent J.; Lekkos, Anthony A.

    1986-01-01

    Of the six or seven phases of the software engineering life cycle, requirements analysis tends to be the least understood and the least formalized. Correspondingly, a scarcity of useful software tools exist which aid in the development of user and system requirements. It is proposed that requirements analysis should culminate in a set of documents similar to those that usually accompany a delivered Software product. The design of a software tool, the Document Structure Editor, which facilitates the development of such documentation.

  14. Authors, editors, and the signs, symptoms and causes of plagiarism

    PubMed Central

    Shashok, Karen

    2011-01-01

    Plagiarism and inadequate citing appear to have reached epidemic proportions in research publication. This article discusses how plagiarism is defined and suggests some possible causes for the increase in the plagiarism disease. Most editors do not have much tolerance for text re-use with inadequate citation regardless of reasons why words are copied from other sources without correct attribution. However, there is now some awareness that re-use of words in research articles to improve the writing or “the English” (which has become a common practice) should be distinguished from intentional deceit for the purpose of stealing other authors’ ideas (which appears to remain a very rare practice). Although it has become almost as easy for editors to detect duplicate text as it is for authors to re-use text from other sources, editors often fail to consider the reasons why researchers resort to this strategy, and tend to consider any text duplication as a symptom of serious misconduct. As a result, some authors may be stigmatized unfairly by being labeled as plagiarists. The article concludes with practical advice for researchers on how to improve their writing and citing skills and thus avoid accusations of plagiarism. PMID:21957412

  15. Authors, editors, and the signs, symptoms and causes of plagiarism.

    PubMed

    Shashok, Karen

    2011-07-01

    Plagiarism and inadequate citing appear to have reached epidemic proportions in research publication. This article discusses how plagiarism is defined and suggests some possible causes for the increase in the plagiarism disease. Most editors do not have much tolerance for text re-use with inadequate citation regardless of reasons why words are copied from other sources without correct attribution. However, there is now some awareness that re-use of words in research articles to improve the writing or "the English" (which has become a common practice) should be distinguished from intentional deceit for the purpose of stealing other authors' ideas (which appears to remain a very rare practice). Although it has become almost as easy for editors to detect duplicate text as it is for authors to re-use text from other sources, editors often fail to consider the reasons why researchers resort to this strategy, and tend to consider any text duplication as a symptom of serious misconduct. As a result, some authors may be stigmatized unfairly by being labeled as plagiarists. The article concludes with practical advice for researchers on how to improve their writing and citing skills and thus avoid accusations of plagiarism. PMID:21957412

  16. Statement on Publication Ethics for Editors and Publishers.

    PubMed

    Gasparyan, Armen Yuri; Yessirkepov, Marlen; Voronov, Alexander A; Gorin, Sergey V; Koroleva, Anna M; Kitas, George D

    2016-09-01

    The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the literature by correcting or retracting related articles. Indexers are advised to implement measures for accepting truly influential and ethical journals and delisting sources with predatory publishing practices. Updating knowledge and skills of authors, editors and publishers, developing and endorsing recommendations of global editorial associations, and (re)drafting journal instructions can be viewed as potential tools for improving ethics of academic journals. The aim of this Statement is to increase awareness of all stakeholders of science communication of the emerging ethical issues in journal editing and publishing and initiate a campaign of upgrading and enforcing related journal instructions. PMID:27510376

  17. An editor's considerations in publishing industry-sponsored studies.

    PubMed

    Droller, Michael J

    2015-03-01

    The fundamental responsibility of a journal editor is to assure that studies accepted for publication provide rigorous original scientific information and reviews that are considered important to the readership. The fundamental requirements of such reports from an editor's perspective include objectivity and transparency in each of the study design, implementation of investigation methods, acquisition of data, inclusive analysis and interpretation of results, appropriate application of statistical methods, presentation of outcomes in the context of a balanced and comprehensive review of relevant literature, and meaningful conclusions. In proceeding on these presumptions, editors then have the responsibility of obtaining rigorous, objective, and constructive reviews of these reports so that they can make an unbiased decision regarding their disposition. The fundamental objective in this is to enhance the ultimate scientific validity and value of the work if and when it is accepted for publication. Guidelines have been advanced by several organizations to identify how such editorial responsibilities can be fulfilled. These guidelines also pertain to investigators, authors, and sponsors of the studies, which the various reports and reviews describe. The present article reviews these guidelines as they relate to both industry-sponsored and investigator-initiated investigations and as relevant to the variety of reports that a scientific/medical journal such as Urologic Oncology: Seminars and Original Investigations receives for publication.

  18. CMS Configuration Editor: GUI based application for user analysis job

    NASA Astrophysics Data System (ADS)

    de Cosa, A.

    2011-12-01

    We present the user interface and the software architecture of the Configuration Editor for the CMS experiment. The analysis workflow is organized in a modular way integrated within the CMS framework that organizes in a flexible way user analysis code. The Python scripting language is adopted to define the job configuration that drives the analysis workflow. It could be a challenging task for users, especially for newcomers, to develop analysis jobs managing the configuration of many required modules. For this reason a graphical tool has been conceived in order to edit and inspect configuration files. A set of common analysis tools defined in the CMS Physics Analysis Toolkit (PAT) can be steered and configured using the Config Editor. A user-defined analysis workflow can be produced starting from a standard configuration file, applying and configuring PAT tools according to the specific user requirements. CMS users can adopt this tool, the Config Editor, to create their analysis visualizing in real time which are the effects of their actions. They can visualize the structure of their configuration, look at the modules included in the workflow, inspect the dependences existing among the modules and check the data flow. They can visualize at which values parameters are set and change them according to what is required by their analysis task. The integration of common tools in the GUI needed to adopt an object-oriented structure in the Python definition of the PAT tools and the definition of a layer of abstraction from which all PAT tools inherit.

  19. A perspective on computer documentation: System developer vs. technical editor

    SciTech Connect

    Carnes, E.T.; Truett, L.F.

    1995-12-31

    Between the computer-knowledgeable {open_quotes}techie{close_quotes} and the technical writer is a chasm created by differences in knowledge bases and skills. Although this gap is widened by misunderstandings and misconceptions of system development roles, it is bridged by mutual need and dual appreciation. Often the editor/writer is {open_quotes}behind{close_quotes} from beginning to end. The writer normally joins the team after the programmers are well into system development and do not want to {open_quotes}waste time{close_quotes} discussing fundamentals. The writer is usually excluded from technical discussions because it is assumed that he/she would not understand anyway. Later in the system development cycle, the writer has no time to polish the documentation before a new version of the software is issued which implies that the documentation must be revised. Nevertheless, the editor/writer`s product is critical for the end-user`s appreciation of the software, a fact which promotes unity to complete the comprehensive package of software and documentation. This paper explores the planks in the bridge that spans the chasm between developers and their fundamental PR agents, the technical editors/writers. This paper defines approaches (e.g., The Circling Theory) and techniques (Bold Thrust!) employed for effective communication -- between software developer and technical writer as well as between the software and the end-user.

  20. Statement on Publication Ethics for Editors and Publishers.

    PubMed

    Gasparyan, Armen Yuri; Yessirkepov, Marlen; Voronov, Alexander A; Gorin, Sergey V; Koroleva, Anna M; Kitas, George D

    2016-09-01

    The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the literature by correcting or retracting related articles. Indexers are advised to implement measures for accepting truly influential and ethical journals and delisting sources with predatory publishing practices. Updating knowledge and skills of authors, editors and publishers, developing and endorsing recommendations of global editorial associations, and (re)drafting journal instructions can be viewed as potential tools for improving ethics of academic journals. The aim of this Statement is to increase awareness of all stakeholders of science communication of the emerging ethical issues in journal editing and publishing and initiate a campaign of upgrading and enforcing related journal instructions.

  1. Statement on Publication Ethics for Editors and Publishers

    PubMed Central

    2016-01-01

    The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the literature by correcting or retracting related articles. Indexers are advised to implement measures for accepting truly influential and ethical journals and delisting sources with predatory publishing practices. Updating knowledge and skills of authors, editors and publishers, developing and endorsing recommendations of global editorial associations, and (re)drafting journal instructions can be viewed as potential tools for improving ethics of academic journals. The aim of this Statement is to increase awareness of all stakeholders of science communication of the emerging ethical issues in journal editing and publishing and initiate a campaign of upgrading and enforcing related journal instructions. PMID:27510376

  2. The lin genes for γ-hexachlorocyclohexane degradation in Sphingomonas sp. MM-1 proved to be dispersed across multiple plasmids.

    PubMed

    Tabata, Michiro; Endo, Ryo; Ito, Michihiro; Ohtsubo, Yoshiyuki; Kumar, Ashwani; Tsuda, Masataka; Nagata, Yuji

    2011-01-01

    A γ-hexachlorocyclohexane (HCH)-degrading bacterium, Sphingomonas sp. MM-1, was isolated from soil contaminated with HCH isomers. Cultivation of MM-1 in the presence of γ-HCH led to the detection of five γ-HCH metabolites, γ-pentachlorocyclohexene, 2,5-dichloro-2,5-cyclohexadiene-1,4-diol, 2,5-dichlorohydroquinone, 1,2,4-trichlorobenzene, and 2,5-dichlorophenol, strongly suggesting that MM-1 has the lin genes for γ-HCH degradation originally identified in the well-studied γ-HCH-degrading strain Sphingobium japonicum UT26. Southern blot, PCR amplification, and sequencing analyses indicated that MM-1 has seven lin genes for the conversion of γ-HCH to β-ketoadipate (six structural genes, linA to linF, and one regulatory gene, linR). MM-1 carried four plasmids, of 200, 50, 40, and 30 kb. Southern blot analysis revealed that all seven lin genes were dispersed across three of the four plasmids, and that IS6100, often found close to the lin genes, was present on all four plasmids. PMID:21389627

  3. Testicular expression of the Lin28/let-7 system: Hormonal regulation and changes during postnatal maturation and after manipulations of puberty

    PubMed Central

    Sangiao-Alvarellos, S.; Manfredi-Lozano, M.; Ruiz-Pino, F.; León, S.; Morales, C.; Cordido, F.; Gaytán, F.; Pinilla, L.; Tena-Sempere, M.

    2015-01-01

    The Lin28/let-7 system, which includes the RNA-binding proteins, Lin28a/Lin28b, and let-7 miRNAs, has emerged as putative regulator of puberty and male gametogenesis; yet, its expression pattern and regulation in postnatal testis remain ill defined. We report herein expression profiles of Lin28 and let-7 members, and related mir-145 and mir-132, in rat testis during postnatal maturation and in models of altered puberty and hormonal deregulation. Neonatal expression of Lin28a and Lin28b was low and rose markedly during the infantile period; yet, expression patterns diverged thereafter, with persistently elevated levels only for Lin28b, which peaked at puberty. Let-7a, let-7b, mir-132 and mir-145 showed profiles opposite to Lin28b. In fact, let-7b and mir-145 were abundant in pachytene spermatocytes, but absent in elongating spermatids, where high expression of Lin28b was previously reported. Perturbation of puberty by neonatal estrogenization reverted the Lin28/let-7 expression ratio; expression changes were also detected in other models of delayed puberty, due to early photoperiod or nutritional manipulations. In addition, hypophysectomy or growth hormone (GH) deficiency revealed regulation of this system by gonadotropins and GH. Our data document the expression profiles of the Lin28/let-7 system in rat testis along postnatal/pubertal maturation, and their perturbation in models of pubertal and hormonal manipulation. PMID:26494358

  4. Greetings from the new Editor-in-Chief, Ronald Stambaugh Greetings from the new Editor-in-Chief, Ronald Stambaugh

    NASA Astrophysics Data System (ADS)

    Stambaugh, Ronald

    2012-04-01

    I am very pleased to join the outstanding leadership team for the journal Nuclear Fusion as Scientific Editor. The journal's high position in the field of fusion energy research derives in no small measure from the efforts of the IAEA team in Vienna, the production and marketing of IOP Publishing, the Board of Editors led by its chairman Mitsuru Kikuchi, the Associate Editor for Inertial Confinement Max Tabak and the outgoing Scientific Editor, Paul Thomas. During Paul's five year tenure submissions have grown by over 40%. The usage of the electronic journal has grown year by year with about 300 000 full text downloads of Nuclear Fusion articles in 2011, an impressive figure due in part to the launch of the full 50 year archive. High quality has been maintained while times for peer review and publishing have been reduced and the journal achieved some of the highest impact factors ever (as high as 4.27). The journal has contributed greatly to building the international scientific basis for fusion. I was privileged to serve from 2003 to 2010 as chairman of the Coordinating Committee for the International Tokamak Physics Activity (ITPA) which published in Nuclear Fusion the first ITER Physics Basis (1999) and its later update (2007). The scientific basis that has been developed to date for fusion has led to the construction of major facilities to demonstrate the production of power-plant relevant levels of fusion reactions. We look forward to the journal continuing to play a key role in the international effort toward fusion energy as these exciting major facilities and the various approaches to fusion continue to be developed. It is clear that Nuclear Fusion maintains its position in the field because of the perceived high quality of the submissions, the refereeing and the editorial processes, and the availability and utility of the online journal. The creation of the Nuclear Fusion Prize, led by the Board of Editors chairman Mitsuru Kikuchi, for the most outstanding

  5. Influence of laser sources with different spectral properties on the performance of vapor cell atomic clocks based on lin||lin CPT.

    PubMed

    Breschi, Evelina; Kazakov, George; Lammegger, Roland; Matisov, Boris; Windholz, Laurentius; Mileti, Gaetano

    2009-05-01

    We evaluate the influence of 2 types of laser sources with different spectral profiles on the performance of vapor cell atomic clocks based on lin||lin coherent population trapping (CPT) resonances. We show that a short-term stability of 1-2 x 10(-11) tau(-1/2) may be reached in a compact system using a modulated vertical cavity surface-emitting laser. Here the stability is limited by the detection noise level and can be improved up to a factor of 4 by increasing the lock-in detection frequency to several tens of kilohertz, which is not possible in standard double resonance atomic clocks. We compare these results with CPT prepared under the same experimental conditions, using 2 phase-locked extended cavity diode lasers, with which we predict a challenging short-term stability of 1-3 x 10(-13) tau(-1/2), comparable to the state-of-the-art laser-pumped Rb-clocks.

  6. Manipulation quantique de la lumière par un amplificateur non linéaire

    NASA Astrophysics Data System (ADS)

    Symul, T.; Bencheikh, K.; Levenson, J. A.

    2002-06-01

    Nous proposons un dispositif original, appelé Amplificateur Non Linéaire (ANL), permettant la génération et la manipulation d'états quantiques de la lumière. Ce dispositif permet une compression du bruit quantique de la lumière en dessous de la limite quantique standard plus efficace que celle obtenue par interactions non linéaires du second ordre ou du troisième ordre. Il permet également d'inverser les fluctuations quantiques en intensité de la lumière, et de produire des photons jumeaux ayant des corrélations quantiques plus élevées et plus robustes que ceux produits par un amplificateur paramétrique seul.

  7. [A new substituted benzamide with neuroleptic effects: lin 14 18 or sultopride].

    PubMed

    Dufour, H; Castelli, J; Luccioni, H; Scotto, J C; Sutter, J M

    1975-01-01

    After the research about Sulpiride, a new substituted benzamide has been studied. Although it was characterized by modest pharmacological effects in the neuroleptic identification tests, LIN 1418 turned out to have very interesting therapeutic properties. A study conducted with 50 cases, 30 of which were submitted a systematic pluridisciplinary control, leads to provisory conclusions as follows: 1) its psychotropic effects are powerful and constant; 2) its prevailing action is antipsychotic and desinhibiting altogether; 3) while LIN 1418 appears as successful with all psychoses, whether acute or chronic, up to now, the quality of its results in many chronic psychoses seems to be particularly remarkable; 4) its side-effects are those of most neuroleptics: its extrapyramidal symptoms being all the more obvious as the patient's "passivity" is less important.

  8. Structural and electronic properties of stable Lin (n=2-10) clusters: A density functional study

    NASA Astrophysics Data System (ADS)

    Chetri, Pawan; Deka, Ramesh Ch.; Choudhury, Amarjyoti

    2013-12-01

    Structure and relative stability of Lin clusters for n=1-10 were investigated using density functional methods based DMol3 program. The structures of Li clusters were determined in terms of Li-Li bond length and the results are in very good agreement with experimental values. Stability of the clusters was determined from their relative energy values binding energies and second difference energy. We also determined fragmentation energy of each size of cluster. We arrived at some interesting result like the transition of Lin from 2-dimension to 3-dimension for a particular value of n and also the variation of HOMO-LUMO gap with cluster size. Many structures are characterized for the first time in this work.

  9. Response to Niklasson's comment on Lin, et al. (2012) : "the relation between postural movement and bilateral motor integration".

    PubMed

    Lin, Chin-Kai; Kuo, Bor-Chen; Wu, Huey-Min

    2014-10-01

    In the study of Lin, Wu, Lin, Wu, Wu, Kuo, and Yeung (2012 ), the relationship between the validity of postural movement and bilateral motor integration in terms of sensory integration theory was examined. Postural movement is the ability to use the antigravity postures required for stabilization of the neck, trunk and upper extremities via muscle co-contractions in the neck and upper extremities, and balance. Niklasson's (2013 ) comment argued that postural movement should include primitive reflexes in terms of the general abilities approach. Niklasson (2013 ) focused on the efficacy of the treatment rather than the theoretical frameworks implied in the therapeutic activities. For that purpose Lin, et al. (2012 ) used sensory integration as the theoretical foundation, and the relationship between postural movement and bilateral motor integration was assessed via empirical data. The result of Lin, et al. (2012 ) was offered as a theoretical reference for therapeutic activities.

  10. Purified CD34+ Lin- Thy+ stem cells do not contain clonal myeloma cells.

    PubMed

    Gazitt, Y; Reading, C C; Hoffman, R; Wickrema, A; Vesole, D H; Jagannath, S; Condino, J; Lee, B; Barlogie, B; Tricot, G

    1995-07-01

    High-dose therapy with autologous marrow or peripheral blood stem cell (PBSC) rescue has been extensively applied in the treatment of multiple myeloma (MM) patients during the past 10 years resulting in improved event-free and overall survival when compared with standard chemotherapy. However, relapses are common and cure is unlikely in the majority of patients. Because both bone marrow and PBSCs are contaminated with myeloma cells it is conceivable that relapse after autotransplantation originates at least in part from autografted tumor cells. In this study, mobilized PBSCs were examined for the presence of myeloma cells based on immunophenotyping and sensitive polymerase chain reaction (PCR)-based techniques. In addition, CD34+ Lin- Thy+ stem cells were purified from mobilized PBSC harvests of 10 MM patients by sequentially using counterflow elutriation centrifugation, treatment with phenylalanine methylester, and flow sorting, using 5-parameter gating (propidium iodide, forward scatter, side scatter, CD34+ v Lin- and CD34+ v Thy+). Virtually all mobilized unsorted PBSC preparations contained myeloma cells in sufficient quantities (range, < 0.01 to > 10%) potentially causing a disease relapse. Stem cell purification led to an overall enrichment by about 50-fold in all 10 patients; approximately 90% of the final cell population expressed CD34+ Lin- Thy+ with no evidence of myeloma cell contamination based on flow cytometric analysis of CD38bright cells (< 0.1%). Quantitative PCR amplification of patient-specific complementarity determining region III (CDRIII) DNA sequences showed depletion of clonal B cells by 2.7 to 7.3 logs, with the highest log reduction noted in the samples initially containing the most tumor cells. Our results show that purification of CD34+ Lin- Thy+ cells depletes myeloma cells to undetectable levels from up to 10% present in unsorted PBSCs, thus offering a tool to investigate whether MM relapse after autotransplantation can be reduced

  11. Degradation of beta-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26.

    PubMed

    Nagata, Yuji; Prokop, Zbynek; Sato, Yukari; Jerabek, Petr; Kumar, Ashwani; Ohtsubo, Yoshiyuki; Tsuda, Masataka; Damborsky, Jirí

    2005-04-01

    Beta-Hexachlorocyclohexane (beta-HCH) is the most recalcitrant among the alpha-, beta-, gamma-, and delta-isomers of HCH and causes serious environmental pollution problems. We demonstrate here that the haloalkane dehalogenase LinB, reported earlier to mediate the second step in the degradation of gamma-HCH in Sphingomonas paucimobilis UT26, metabolizes beta-HCH to produce 2,3,4,5,6-pentachlorocyclohexanol.

  12. EDITORIAL: Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Bhattacharya, P.

    2004-04-01

    On 1 January, 2004, I assumed the position of Editor-in-Chief of Journal of Physics D: Applied Physics. I will start by saying that I will do my best to justify the confidence of the journal management and publishing staff in my abilities. I was fortunate to have been able to work, as an Editorial Board member, with my predecessor, the previous Editor-in-Chief, Professor Allister Ferguson. Allister has provided a high degree of intellectual stewardship for the journal in the last five years. He has made the job appear a worthy challenge for me. I therefore take this opportunity to thank Allister on behalf of the Editorial Board and publishing staff of the journal. Several other factors contributed to my decision to accept this position. The first is the group of people who actually go about the business of publishing. The Senior Publisher, Nicola Gulley (and her predecessor Sophy Le Masurier); the Managing Editor, Jill Membrey; the Publishing Administrators, Nina Blakesley and Sarah Towell; the Production Editor, Katie Gerrard and their office staff form an amazing group and have managed to make the operation of the journal incredibly efficient. An index of this is the speed with which incoming manuscripts are processed. The average time between the receipt of a manuscript and its web publication, if accepted, is 130 days. This is three to five times shorter than for most other journals. A factor that contributes to this success is a responsive pool of referees that the publishing staff have as a valuable resource. Ultimately, the standard bearers of any journal are the referees. Therefore, a grateful `thank you' is due from all of us at J. Phys. D to all our referees, who diligently perform this honourable task. The Associate Editors of the journal, Professors Lawler, Margaritondo and O'Grady, also provide immense scientific leadership. They help in defining new directions for the journal and in the publishing process. Last, but not least, a remarkable asset of

  13. Problems faced by editors of peer reviewed medical journals.

    PubMed

    Jawaid, Shaukat A

    2004-01-01

    Forty-six medical and dental journals are published from Pakistan of which only 29 are currently recognized by the Pakistan Medical and Dental Council. Only a few are peer reviewed. Six are indexed in Medline while EMBASE Excerpta Medica and World Health Organization Index Medicus for Eastern Mediterranean Region cover others. Editors of the peer reviewed medical journals are faced with numerous problems, which relate to the authors. Some of these are: shortage of quality of manuscripts, poor quality of reviewers, problems with indexation in international indexing services particularly Medline, duplicate submission and authorship and lastly, financial problems. Patronage from the Pharma industry is the major source of revenue which itself has serious implications. Editing a medical journal is a very stressful job and the editors have to work under too many pressures. A lot of useful data is presented at medical conferences, but a vast majority of it remains unpublished for various reasons, which adversely affects the citation rate from scientists from the developing third world countries in the world of medical literature. A few lectures on medical writing and research methodology to final year medical students will expose them to the art of medical writing. Specialty organizations can be persuaded to have a session on medical writing at their conferences, which will be extremely helpful not only to the potential new authors but also others, thereby improving the quality of their manuscripts. In addition to regular seminars, workshops for authors, reviewers and training courses for editors, subscribing to local medical journals by healthcare professionals and libraries are some of the measures that will help improve the situation to a great extent.

  14. Evaluation of arsenic contamination potential using indicator kriging in the Yun-Lin aquifer (Taiwan).

    PubMed

    Liu, Chen-Wuing; Jang, Cheng-Shin; Liao, Chung-Min

    2004-04-01

    Data on the quality of groundwater obtained from several multi-level monitoring wells indicated that arsenic (As) concentration far exceeds the drinking water supply standard in the coastal aquifer of the Yun-Lin, Taiwan. In this study, an estimated As probability risk was computed using indicator kriging to assess the As contamination potential of exceeding the drinking water supply standard in the Yun-Lin county. A three-dimensional (3D) spatial variability model was presented to analyze anisotropically the variation of As concentration using a multi-level threshold indicator variable. This 3D estimator overcomes the scarcity of the data and establishes a vertical correlation of measured As data. The results indicate high As pollution probability in the coastal area and in the Pei-Kang river basin. The highest probability, 0.92, of the As pollution is in the shallow aquifer of the Kou-Hu. The contamination potential of As is primarily within an aquifer depth of 180 m. The contaminated aquifer (<180 m) is not suitable for supplying drinking water. The contamination potential of As is low at the depths of more than 190 m. However, the probabilities associated with the As pollution still exceed 0.2 in the deep aquifer of four coastal townships of the Yun-Lin, and may pose risks to human health if the groundwater is used for drinking.

  15. Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters.

    PubMed

    Marceau, Aimee H; Felthousen, Jessica G; Goetsch, Paul D; Iness, Audra N; Lee, Hsiau-Wei; Tripathi, Sarvind M; Strome, Susan; Litovchick, Larisa; Rubin, Seth M

    2016-01-01

    The MuvB complex recruits transcription factors to activate or repress genes with cell cycle-dependent expression patterns. MuvB contains the DNA-binding protein LIN54, which directs the complex to promoter cell cycle genes homology region (CHR) elements. Here we characterize the DNA-binding properties of LIN54 and describe the structural basis for recognition of a CHR sequence. We biochemically define the CHR consensus as TTYRAA and determine that two tandem cysteine rich regions are required for high-affinity DNA association. A crystal structure of the LIN54 DNA-binding domain in complex with a CHR sequence reveals that sequence specificity is conferred by two tyrosine residues, which insert into the minor groove of the DNA duplex. We demonstrate that this unique tyrosine-mediated DNA binding is necessary for MuvB recruitment to target promoters. Our results suggest a model in which MuvB binds near transcription start sites and plays a role in positioning downstream nucleosomes.

  16. Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters

    PubMed Central

    Marceau, Aimee H.; Felthousen, Jessica G.; Goetsch, Paul D.; Iness, Audra N.; Lee, Hsiau-Wei; Tripathi, Sarvind M.; Strome, Susan; Litovchick, Larisa; Rubin, Seth M.

    2016-01-01

    The MuvB complex recruits transcription factors to activate or repress genes with cell cycle-dependent expression patterns. MuvB contains the DNA-binding protein LIN54, which directs the complex to promoter cell cycle genes homology region (CHR) elements. Here we characterize the DNA-binding properties of LIN54 and describe the structural basis for recognition of a CHR sequence. We biochemically define the CHR consensus as TTYRAA and determine that two tandem cysteine rich regions are required for high-affinity DNA association. A crystal structure of the LIN54 DNA-binding domain in complex with a CHR sequence reveals that sequence specificity is conferred by two tyrosine residues, which insert into the minor groove of the DNA duplex. We demonstrate that this unique tyrosine-mediated DNA binding is necessary for MuvB recruitment to target promoters. Our results suggest a model in which MuvB binds near transcription start sites and plays a role in positioning downstream nucleosomes. PMID:27465258

  17. Lin28 and let-7: ancient milestones on the road from pluripotency to neurogenesis.

    PubMed

    Rehfeld, Frederick; Rohde, Anna Maria; Nguyen, Duong Thi Thuy; Wulczyn, F Gregory

    2015-01-01

    Beginning with their discovery in the context of stem cell fate choice in Caenorhabditis elegans, the microRNA (miRNA) let-7 and the RNA-binding protein Lin28 have been recognized as a regulatory pair with far-reaching impact on stem cell behavior in a wide range of organisms and tissues, including the mammalian brain. In this review, we describe molecular interactions between Lin28 and let-7 and the biological role that each plays in implementing stem cell programs that either maintain stem cell self-renewal and plasticity or drive lineage commitment and differentiation. For Lin28, considerable progress has been made in defining let-7-dependent and let-7-independent functions in the maintenance of pluripotency, somatic cell reprogramming, tissue regeneration, and neural stem cell plasticity. For the pro-differentiation activity of let-7, we focus on emerging roles in mammalian neurogenesis and neuronal function. Specific targets and pathways for let-7 have been identified in embryonic and adult neurogenesis, including corticogenesis, retinal specification, and adult neurogenic niches. Special emphasis is given to examples of feedback and feedforward regulation, in particular within the miRNA biogenesis pathway.

  18. Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia

    PubMed Central

    Chen, Lili; Sun, Yuqing; Wang, Jingya; Jiang, Hui; Muntean, Andrew G.

    2016-01-01

    MLL rearrangements occur in myeloid and lymphoid leukemias and are generally associated with a poor prognosis, however this varies depending on the fusion partner. We modeled acute myeloid leukemia (AML) in mice using various MLL fusion proteins (MLL-FPs) and observed significantly different survival outcomes. To better understand the differences between these leukemias, we examined the genome wide expression profiles of leukemic cells transformed with different MLL-FPs. RNA-sequencing and pathway analysis identified the c-Myc transcriptional program as one of the top distinguishing features. c-Myc protein levels were highly correlative with AML disease latency in mice. Functionally, overexpression of c-Myc resulted in a more aggressive proliferation rate in MLL-FP cell lines. While all MLL-FP transformed cells displayed sensitivity to BET inhibitors, high c-Myc expressing cells showed greater resistance to Brd4 inhibition. The Myc target Lin28B was also differentially expressed in MLL-FP cell lines in agreement with c-Myc expression. Examination of Lin28B miRNAs targets revealed that let-7g was significantly increased in leukemic cells associated with the longest disease latency and forced let-7g expression induced differentiation of leukemic blasts. Thus, differential regulation of the c-Myc/Lin28/let-7g program by different MLL-FPs is functionally related to disease latency and BET inhibitor resistance in MLL leukemias. PMID:27007052

  19. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Nielsch, Kornelius

    2012-01-01

    On 1 January 2012 I will be assuming the position of Editor-in-Chief of the journal Semiconductor Science and Technology (SST). I am flattered by the confidence expressed in my ability to carry out this challenging job and I will try hard to justify this confidence. The previous Editor-in-Chief, Laurens Molenkamp, University of Würzburg, Germany, has worked tirelessly for the last ten years and has done an excellent job for the journal. Everyone at the journal is profoundly grateful for his leadership and for his achievements In 2012 several new members will join the Editorial Board: Professor Deli Wang (University of California, San Diego) with considerable expertise in semiconductor nanowires, Professor Saskia Fischer (Humboldt University, Berlin, Germany) with a background in semiconductor quantum devices, and Professor Erwin Kessels (Eindhoven University of Technology, Netherlands) with extensive experience in plasma processing of thin films and gate oxides. In particular, I want to express my gratitude to Professor Israel Bar-Joseph (Weizmann Institute of Science, Israel) and Professor Maria Tamargo (The City College of New York, USA), who will leave next year and who have vigorously served the Editorial Board for years. The journal has recently introduced a fast-track option for manuscripts. This option is a high-quality, high-profile outlet for new and important research across all areas of semiconductor research. Authors can expect to receive referee reports in less than 20 days from submission. Once accepted, you can expect the articles to be online within two or three weeks from acceptance and to be published in print in less than a month. Furthermore, all fast-track communications published in 2011 will be free to read for ten years. More detailed information on fast-track publication can be found on the following webpage: http://iopscience.iop.org/0268-1242/page/Fast track communications It is encouraging to see that since the journal introduced pre

  20. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Nielsch, Kornelius

    2012-01-01

    On 1 January 2012 I will be assuming the position of Editor-in-Chief of the journal Semiconductor Science and Technology (SST). I am flattered by the confidence expressed in my ability to carry out this challenging job and I will try hard to justify this confidence. The previous Editor-in-Chief, Laurens Molenkamp, University of Würzburg, Germany, has worked tirelessly for the last ten years and has done an excellent job for the journal. Everyone at the journal is profoundly grateful for his leadership and for his achievements In 2012 several new members will join the Editorial Board: Professor Deli Wang (University of California, San Diego) with considerable expertise in semiconductor nanowires, Professor Saskia Fischer (Humboldt University, Berlin, Germany) with a background in semiconductor quantum devices, and Professor Erwin Kessels (Eindhoven University of Technology, Netherlands) with extensive experience in plasma processing of thin films and gate oxides. In particular, I want to express my gratitude to Professor Israel Bar-Joseph (Weizmann Institute of Science, Israel) and Professor Maria Tamargo (The City College of New York, USA), who will leave next year and who have vigorously served the Editorial Board for years. The journal has recently introduced a fast-track option for manuscripts. This option is a high-quality, high-profile outlet for new and important research across all areas of semiconductor research. Authors can expect to receive referee reports in less than 20 days from submission. Once accepted, you can expect the articles to be online within two or three weeks from acceptance and to be published in print in less than a month. Furthermore, all fast-track communications published in 2011 will be free to read for ten years. More detailed information on fast-track publication can be found on the following webpage: http://iopscience.iop.org/0268-1242/page/Fast track communications It is encouraging to see that since the journal introduced pre

  1. EDITORIAL: Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Garcia, Ephrahim

    2008-02-01

    I am Professor Ephrahim Garcia, an Associate Professor at Sibley School of Mechanical and Aerospace Engineering at Cornell University in Ithaca, New York. I have been at Cornell University since 2002, spent four years as a Program Manager at the Defense Advanced Research Project Agency from 1998-2002, and before that seven years at the Department of Mechanical Engineering at Vanderbilt University in Nashville, Tennessee. I have served on the Editorial Advisory Board of Smart Materials and Structures (SMS) for the last six years. It is a humbling thing to be asked to take up the post of Editor-in-Chief in a field with so many talented researchers. I would like to say a heartfelt thanks to the members of the Editorial Board and IOP Publishing for their confidence in me. Most importantly, I would like to thank Professor Vijay Varadan of the University of Arkansas and Professor Richard Claus of Virginia Polytechnic Institute and State University for their efforts in launching the journal 16 years ago. They have been stewards, promoters and, especially Vijay, key to the operation and function of SMS for all these years, and our research community is indebted to them. Professors Varadan and Claus have dedicated their careers to the area of smart materials and structures and we are very grateful for their leadership, mentoring and contribution. SMS is a thriving journal offering papers on all technical areas concerned with smart materials, systems and structures from the micro- and nanoscale to the macroscale. The journal is undergoing some major changes, including the recent transferal of papers to IOP Publishing's peer-review management system. With this new system authors can expect fast publication times of around 4 or 5 months from submission, and excellent author service. In this world of ever changing technology, the Editorial Board and I aim to reduce the time to publication for researchers in this exciting area of science and engineering. I am in the process of

  2. The Matrix Editor for symbolic Jacobians in ALPAL

    SciTech Connect

    Painter, J.F.

    1991-12-01

    ALPAL is a Macsyma-based tool that automatically generates code to solve nonlinear integro-differential equations, given a very high-level specification of the equations to be solved and the numerical methods to be used. The Matrix Editor is a graphical, interactive tool for specifying the handling of Jacobian matrices and linear solvers. It automates such routine but difficult tasks as correctly converting from the data structures used for computing the Jacobian to data structures used by a linear solver. The user specifies what to do only at a high, natural level of abstraction.

  3. Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.

    PubMed

    Herrera, R Antonio; Kiontke, Karin; Fitch, David H A

    2016-03-01

    The heterochronic genes lin-28, let-7 and lin-41 regulate fundamental developmental transitions in animals, such as stemness versus differentiation and juvenile versus adult states. We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans. Mutations in lep-2 cause a delay in the juvenile-to-adult transition, with adult males retaining pointed, juvenile tail tips, and displaying defective sexual behaviors. In both sexes, lep-2 mutants fail to cease molting or produce an adult cuticle. We find that LEP-2 post-translationally regulates LIN-28 by promoting LIN-28 protein degradation. lep-2 encodes the sole C. elegans ortholog of the Makorin (Mkrn) family of proteins. Like lin-28 and other heterochronic pathway members, vertebrate Mkrns are involved in developmental switches, including the timing of pubertal onset in humans. Based on shared roles, conservation and the interaction between lep-2 and lin-28 shown here, we propose that Mkrns, together with other heterochronic genes, constitute an evolutionarily ancient conserved module regulating switches in development.

  4. High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells.

    PubMed

    Enriquez, Vanessa A; Cleys, Ellane R; Da Silveira, Juliano C; Spillman, Monique A; Winger, Quinton A; Bouma, Gerrit J

    2015-01-01

    Epithelial ovarian cancer is the most aggressive and deadly form of ovarian cancer and is the most lethal gynecological malignancy worldwide; therefore, efforts to elucidate the molecular factors that lead to epithelial ovarian cancer are essential to better understand this disease. Recent studies reveal that tumor cells release cell-secreted vesicles called exosomes and these exosomes can transfer RNAs and miRNAs to distant sites, leading to cell transformation and tumor development. The RNA-binding protein LIN28 is a known marker of stem cells and when expressed in cancer, it is associated with poor tumor outcome. We hypothesized that high LIN28 expressing ovarian cancer cells secrete exosomes that can be taken up by nontumor cells and cause changes in gene expression and cell behavior associated with tumor development. IGROV1 cells were found to contain high LIN28A and secrete exosomes that were taken up by HEK293 cells. Moreover, exposure to these IGROV1 secreted exosomes led to significant increases in genes involved in Epithelial-to-Mesenchymal Transition (EMT), induced HEK293 cell invasion and migration. These changes were not observed with exosomes secreted by OV420 cells, which contain no detectable amounts of LIN28A or LIN28B. No evidence was found of LIN28A transfer from IGROV1 exosomes to HEK293 cells.

  5. Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase.

    PubMed Central

    Jacobs, D; Beitel, G J; Clark, S G; Horvitz, H R; Kornfeld, K

    1998-01-01

    Genetic analysis of lin-1 loss-of-function mutations suggests that lin-1 controls multiple cell-fate decisions during Caenorhabditis elegans development and is negatively regulated by a conserved receptor tyrosine kinase-Ras-ERK mitogen-activated protein (MAP) kinase signal transduction pathway. LIN-1 protein contains an ETS domain and presumably regulates transcription. We identified and characterized six gain-of-function mutations that define a new class of lin-1 allele. These lin-1 alleles appeared to be constitutively active and unresponsive to negative regulation. Each allele has a single-base change that affects the predicted C terminus of LIN-1, suggesting this region is required for negative regulation. The C terminus of LIN-1 was a high-affinity substrate for Erk2 in vitro, suggesting that LIN-1 is directly regulated by ERK MAP kinase. Because mpk-1 ERK MAP kinase controls at least one cell-fate decision that does not require lin-1, our results suggest that MPK-1 contributes to the specificity of this receptor tyrosine kinase-Ras-MAP kinase signal transduction pathway by phosphorylating different proteins in different developmental contexts. These lin-1 mutations all affect a four-amino-acid motif, FQFP, that is conserved in vertebrate and Drosophila ETS proteins that are also phosphorylated by ERK MAP kinase. This sequence may be a substrate recognition motif for the ERK subfamily of MAP kinases. PMID:9691039

  6. 29 CFR 793.8 - “News editor.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee...

  7. 29 CFR 793.8 - “News editor.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee...

  8. Gene targeting, genome editing: from Dolly to editors.

    PubMed

    Tan, Wenfang; Proudfoot, Chris; Lillico, Simon G; Whitelaw, C Bruce A

    2016-06-01

    One of the most powerful strategies to investigate biology we have as scientists, is the ability to transfer genetic material in a controlled and deliberate manner between organisms. When applied to livestock, applications worthy of commercial venture can be devised. Although initial methods used to generate transgenic livestock resulted in random transgene insertion, the development of SCNT technology enabled homologous recombination gene targeting strategies to be used in livestock. Much has been accomplished using this approach. However, now we have the ability to change a specific base in the genome without leaving any other DNA mark, with no need for a transgene. With the advent of the genome editors this is now possible and like other significant technological leaps, the result is an even greater diversity of possible applications. Indeed, in merely 5 years, these 'molecular scissors' have enabled the production of more than 300 differently edited pigs, cattle, sheep and goats. The advent of genome editors has brought genetic engineering of livestock to a position where industry, the public and politicians are all eager to see real use of genetically engineered livestock to address societal needs. Since the first transgenic livestock reported just over three decades ago the field of livestock biotechnology has come a long way-but the most exciting period is just starting.

  9. Gene targeting, genome editing: from Dolly to editors.

    PubMed

    Tan, Wenfang; Proudfoot, Chris; Lillico, Simon G; Whitelaw, C Bruce A

    2016-06-01

    One of the most powerful strategies to investigate biology we have as scientists, is the ability to transfer genetic material in a controlled and deliberate manner between organisms. When applied to livestock, applications worthy of commercial venture can be devised. Although initial methods used to generate transgenic livestock resulted in random transgene insertion, the development of SCNT technology enabled homologous recombination gene targeting strategies to be used in livestock. Much has been accomplished using this approach. However, now we have the ability to change a specific base in the genome without leaving any other DNA mark, with no need for a transgene. With the advent of the genome editors this is now possible and like other significant technological leaps, the result is an even greater diversity of possible applications. Indeed, in merely 5 years, these 'molecular scissors' have enabled the production of more than 300 differently edited pigs, cattle, sheep and goats. The advent of genome editors has brought genetic engineering of livestock to a position where industry, the public and politicians are all eager to see real use of genetically engineered livestock to address societal needs. Since the first transgenic livestock reported just over three decades ago the field of livestock biotechnology has come a long way-but the most exciting period is just starting. PMID:26847670

  10. Reconstruct: a free editor for serial section microscopy.

    PubMed

    Fiala, J C

    2005-04-01

    Many microscopy studies require reconstruction from serial sections, a method of analysis that is sometimes difficult and time-consuming. When each section is cut, mounted and imaged separately, section images must be montaged and realigned to accurately analyse and visualize the three-dimensional (3D) structure. Reconstruct is a free editor designed to facilitate montaging, alignment, analysis and visualization of serial sections. The methods used by Reconstruct for organizing, transforming and displaying data enable the analysis of series with large numbers of sections and images over a large range of magnifications by making efficient use of computer memory. Alignments can correct for some types of non-linear deformations, including cracks and folds, as often encountered in serial electron microscopy. A large number of different structures can be easily traced and placed together in a single 3D scene that can be animated or saved. As a flexible editor, Reconstruct can reduce the time and resources expended for serial section studies and allows a larger tissue volume to be analysed more quickly.

  11. Letters to the editor: definitely not children of a lesser god.

    PubMed

    Papanas, N; Georgiadis, G S; Maltezos, E; Lazarides, M K

    2009-10-01

    Letters to the editor are brief texts that are published in a special section of medical journals. There are two types of letters to the editor: the observation and the comment. The former presents original work, while the latter constitutes criticism on work already published in the same journal. Although short, letters to the editor require as much effort and discipline in writing as, indeed, any other manuscript. Clarity and brevity should be their principal values. It is also important to comply with the journals' instructions for correspondence. Thus, eloquent letters to the editor may promote knowledge and enable fruitful exchange of ideas.

  12. A Generic Metadata Editor Supporting System Using Drupal CMS

    NASA Astrophysics Data System (ADS)

    Pan, J.; Banks, N. G.; Leggott, M.

    2011-12-01

    Metadata handling is a key factor in preserving and reusing scientific data. In recent years, standardized structural metadata has become widely used in Geoscience communities. However, there exist many different standards in Geosciences, such as the current version of the Federal Geographic Data Committee's Content Standard for Digital Geospatial Metadata (FGDC CSDGM), the Ecological Markup Language (EML), the Geography Markup Language (GML), and the emerging ISO 19115 and related standards. In addition, there are many different subsets within the Geoscience subdomain such as the Biological Profile of the FGDC (CSDGM), or for geopolitical regions, such as the European Profile or the North American Profile in the ISO standards. It is therefore desirable to have a software foundation to support metadata creation and editing for multiple standards and profiles, without re-inventing the wheels. We have developed a software module as a generic, flexible software system to do just that: to facilitate the support for multiple metadata standards and profiles. The software consists of a set of modules for the Drupal Content Management System (CMS), with minimal inter-dependencies to other Drupal modules. There are two steps in using the system's metadata functions. First, an administrator can use the system to design a user form, based on an XML schema and its instances. The form definition is named and stored in the Drupal database as a XML blob content. Second, users in an editor role can then use the persisted XML definition to render an actual metadata entry form, for creating or editing a metadata record. Behind the scenes, the form definition XML is transformed into a PHP array, which is then rendered via Drupal Form API. When the form is submitted the posted values are used to modify a metadata record. Drupal hooks can be used to perform custom processing on metadata record before and after submission. It is trivial to store the metadata record as an actual XML file

  13. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.

    PubMed

    Bohl, Joanna; Brimer, Nicole; Lyons, Charles; Vande Pol, Scott B

    2007-03-30

    MPP7, a previously uncharacterized member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, was found in a tripartite complex with DLG1 and LIN7A or LIN7C. MPP7 dimerizes with all three LIN7 family members (LIN7A, -B, and -C) through interaction of the single L27 domain of LIN7 with the carboxyl-terminal L27 domain of MPP7, thereby stabilizing both proteins. The dimer of MPP7 with LIN7A or LIN7C associates with DLG1 through an interaction requiring the amino-terminal L27 domain of MPP7. The amino-terminal L27 domain of MPP7 is not sufficient for interaction with DLG1 but interacts efficiently only if MPP7 is in a complex with LIN7A or -C. Thus the specificity of interaction of DLG1 with the LIN7-MPP7 complex is determined by L27 interactions with both MPP7 and LIN7. The tripartite complex forms in a ratio of 1:1:1 and localizes to epithelial adherens junctions in a manner dependent upon MPP7. Expression of MPP7 stabilizes DLG1 in an insoluble compartment. Expression of MPP7 deleted of the PDZ or Src homology 3 domain redistributes MPP7, DLG1, and LIN7 out of adherens junctions and into the soluble cytoplasmic fraction without changing the localization of E-cadherin. Thus, the stability and localization of DLG1 to cell-cell junctions are complex functions determined by the expression and association of particular Stardust family members together with particular LIN7 family members.

  14. Overexpression of Lin28 Decreases the Chemosensitivity of Gastric Cancer Cells to Oxaliplatin, Paclitaxel, Doxorubicin, and Fluorouracil in Part via microRNA-107

    PubMed Central

    Teng, Rongyue; Hu, Yan; Zhou, Jichun; Seifer, Benjamin; Chen, Yongxia

    2015-01-01

    Higher Lin28 expression is associated with worse pathologic tumor responses in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy. However, the characteristics of Lin28 and its mechanism of action in chemotherapy resistance is still unclear. In this study, we found that transfection of Lin28 into gastric cancer cells (MKN45 and MKN28) increased their resistance to the chemo-drugs oxaliplatin (OXA), paclitaxel (PTX), doxorubicin (ADM), and fluorouracil (5-Fu) compared with gastric cancer cells transfected with a control vector. When knockdown Lin28 expression by Lin28 small interfering RNA (siRNA) was evaluated in vitro, we found that the resistance to chemo-drugs was reduced. Furthermore, we found that Lin28 up-regulates C-myc and P-gp and down-regulates Cylin D1. Finally, we found that miR-107 is a target microRNA of Lin28 and that it participates in the mechanism of chemotherapy resistance. Our results suggest that the Lin28/miR-107 pathway could be one of many signaling pathways regulated by Lin28 and associated with gastric cancer chemo-resistance. PMID:26636340

  15. Organization of lin genes and IS6100 among different strains of hexachlorocyclohexane-degrading Sphingomonas paucimobilis: evidence for horizontal gene transfer.

    PubMed

    Dogra, Charu; Raina, Vishakha; Pal, Rinku; Suar, Mrutyunjay; Lal, Sukanya; Gartemann, Karl-Heinz; Holliger, Christof; van der Meer, Jan Roelof; Lal, Rup

    2004-04-01

    The organization of lin genes and IS6100 was studied in three strains of Sphingomonas paucimobilis (B90A, Sp+, and UT26) which degraded hexachlorocyclohexane (HCH) isomers but which had been isolated at different geographical locations. DNA-DNA hybridization data revealed that most of the lin genes in these strains were associated with IS6100, an insertion sequence classified in the IS6 family and initially found in Mycobacterium fortuitum. Eleven, six, and five copies of IS6100 were detected in B90A, Sp+, and UT26, respectively. IS6100 elements in B90A were sequenced from five, one, and one regions of the genomes of B90A, Sp+, and UT26, respectively, and were found to be identical. DNA-DNA hybridization and DNA sequencing of cosmid clones also revealed that S. paucimobilis B90A contains three and two copies of linX and linA, respectively, compared to only one copy of these genes in strains Sp+ and UT26. Although the copy number and the sequence of the remaining genes of the HCH degradative pathway (linB, linC, linD, and linE) were nearly the same in all strains, there were striking differences in the organization of the linA genes as a result of replacement of portions of DNA sequences by IS6100, which gave them a strange mosaic configuration. Spontaneous deletion of linD and linE from B90A and of linA from Sp+ occurred and was associated either with deletion of a copy of IS6100 or changes in IS6100 profiles. The evidence gathered in this study, coupled with the observation that the G+C contents of the linA genes are lower than that of the remaining DNA sequence of S. paucimobilis, strongly suggests that all these strains acquired the linA gene through horizontal gene transfer mediated by IS6100. The association of IS6100 with the rest of the lin genes further suggests that IS6100 played a role in shaping the current lin gene organization.

  16. Portable EDITOR (PEDITOR): A portable image processing system. [satellite images

    NASA Technical Reports Server (NTRS)

    Angelici, G.; Slye, R.; Ozga, M.; Ritter, P.

    1986-01-01

    The PEDITOR image processing system was created to be readily transferable from one type of computer system to another. While nearly identical in function and operation to its predecessor, EDITOR, PEDITOR employs additional techniques which greatly enhance its portability. These cover system structure and processing. In order to confirm the portability of the software system, two different types of computer systems running greatly differing operating systems were used as target machines. A DEC-20 computer running the TOPS-20 operating system and using a Pascal Compiler was utilized for initial code development. The remaining programmers used a Motorola Corporation 68000-based Forward Technology FT-3000 supermicrocomputer running the UNIX-based XENIX operating system and using the Silicon Valley Software Pascal compiler and the XENIX C compiler for their initial code development.

  17. Educating science editors: is there a comprehensive strategy?

    PubMed Central

    Gasparyan, Armen Yuri; Yessirkepov, Marlen; Gorin, Sergey V.; Kitas, George D.

    2014-01-01

    The article considers available options to educate science editors in the fast-transforming digital environment. There is no single course or resource that can cover their constantly changing and diversifying educational needs. The involvement in research, writing, and reviewing is important for gaining editing skills, but that is not all. Membership in editorial associations and access to updated scholarly information in the field are mandatory for maintaining editorial credentials. Learned associations offer access to a few widely-recognized periodicals. There are also formal training courses covering issues in science writing and ethical editing, but no high-level evidence data exist to promote any of these. Networking with like-minded specialists within the global and regional editorial associations seems a useful strategy to upgrade editorial skills and resolve problems with the quality control and digitization of scholarly periodicals. PMID:25559840

  18. A Diagram Editor for Efficient Biomedical Knowledge Capture and Integration

    PubMed Central

    Yu, Bohua; Jakupovic, Elvis; Wilson, Justin; Dai, Manhong; Xuan, Weijian; Mirel, Barbara; Athey, Brian; Watson, Stanley; Meng, Fan

    2008-01-01

    Understanding the molecular mechanisms underlying complex disorders requires the integration of data and knowledge from different sources including free text literature and various biomedical databases. To facilitate this process, we created the Biomedical Concept Diagram Editor (BCDE) to help researchers distill knowledge from data and literature and aid the process of hypothesis development. A key feature of BCDE is the ability to capture information with a simple drag-and-drop. This is a vast improvement over manual methods of knowledge and data recording and greatly increases the efficiency of the biomedical researcher. BCDE also provides a unique concept matching function to enforce consistent terminology, which enables conceptual relationships deposited by different researchers in the BCDE database to be mined and integrated for intelligible and useful results. We hope BCDE will promote the sharing and integration of knowledge from different researchers for effective hypothesis development. PMID:21347131

  19. The X-windows interactive navigation data editor

    NASA Technical Reports Server (NTRS)

    Rinker, G. C.

    1992-01-01

    A new computer program called the X-Windows Interactive Data Editor (XIDE) was developed and demonstrated as a prototype application for editing radio metric data in the orbit-determination process. The program runs on a variety of workstations and employs pull-down menus and graphical displays, which allow users to easily inspect and edit radio metric data in the orbit data files received from the Deep Space Network (DSN). The XIDE program is based on the Open Software Foundation OSF/Motif Graphical User Interface (GUI) and has proven to be an efficient tool for editing radio metric data in the navigation operations environment. It was adopted by the Magellan Navigation Team as their primary data-editing tool. Because the software was designed from the beginning to be portable, the prototype was successfully moved to new workstation environments. It was also itegrated into the design of the next-generation software tool for DSN multimission navigation interactive launch support.

  20. Educating science editors: is there a comprehensive strategy?

    PubMed

    Gasparyan, Armen Yuri; Yessirkepov, Marlen; Gorin, Sergey V; Kitas, George D

    2014-12-01

    The article considers available options to educate science editors in the fast-transforming digital environment. There is no single course or resource that can cover their constantly changing and diversifying educational needs. The involvement in research, writing, and reviewing is important for gaining editing skills, but that is not all. Membership in editorial associations and access to updated scholarly information in the field are mandatory for maintaining editorial credentials. Learned associations offer access to a few widely-recognized periodicals. There are also formal training courses covering issues in science writing and ethical editing, but no high-level evidence data exist to promote any of these. Networking with like-minded specialists within the global and regional editorial associations seems a useful strategy to upgrade editorial skills and resolve problems with the quality control and digitization of scholarly periodicals.

  1. Advanced software development workstation project: Engineering scripting language. Graphical editor

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Software development is widely considered to be a bottleneck in the development of complex systems, both in terms of development and in terms of maintenance of deployed systems. Cost of software development and maintenance can also be very high. One approach to reducing costs and relieving this bottleneck is increasing the reuse of software designs and software components. A method for achieving such reuse is a software parts composition system. Such a system consists of a language for modeling software parts and their interfaces, a catalog of existing parts, an editor for combining parts, and a code generator that takes a specification and generates code for that application in the target language. The Advanced Software Development Workstation is intended to be an expert system shell designed to provide the capabilities of a software part composition system.

  2. An Internet-based ontology editor for medical appropriateness criteria.

    PubMed

    Kahn, C E

    1998-04-01

    Appropriateness criteria and practice guidelines seek to promote the cost-effectiveness use of medical interventions, and can be most useful when integrated with computer-based patient records and order-entry systems. Building an abstract model (ontology) of appropriateness criteria can require considerable effort among investigators at geographically dispersed institutions. To facilitate the construction and maintenance of ontologies for clinical appropriateness criteria, the author developed an Internet-based system for viewing and editing the knowledge model. The system, called NEON (Network-based Editor for ONtologies), uses the World Wide Web as a platform-independent user interface. NEON allows users to edit the indexing terms and the semantic network that form the ontology for a set of appropriateness criteria. Ontologies built using the system can be imported and exported using an open, internationally standardized format based on the Standard Generalized Markup Language (SGML).

  3. The Murine Bladder Supports a Population of Stromal Sca-1+/CD34+/lin- Mesenchymal Stem Cells

    PubMed Central

    Lilly, Meredith A.; Kulkulka, Natalie A.; Firmiss, Paula R.; Ross, Michael J.; Flum, Andrew S.; Santos, Grace B. Delos; Bowen, Diana K.; Dettman, Robert W.; Gong, Edward M.

    2015-01-01

    Bladder fibrosis is an undesired end point of injury of obstruction and often renders the smooth muscle layer noncompliant. In many cases, the long-term effect of bladder fibrosis is renal failure. Despite our understanding of the progression of this disease, little is known about the cellular mechanisms that lead to a remodeled bladder wall. Resident stem (progenitor) cells have been identified in various organs such as the brain, heart and lung. These cells function normally during organ homeostasis, but become dysregulated after organ injury. Here, we aimed to characterize a mesenchymal progenitor cell population as a first step in understanding its role in bladder fibrosis. Using fluorescence activated cell sorting (FACS), we identified a Sca-1+/ CD34+/ lin- (PECAM-: CD45-: Ter119-) population in the adult murine bladder. These cells were localized to the stromal layer of the adult bladder and appeared by postnatal day 1. Cultured Sca-1+/ CD34+/ lin- bladder cells self-renewed, formed colonies and spontaneously differentiated into cells expressing smooth muscle genes. These cells differentiated into other mesenchymal lineages (chondrocytes, adipocytes and osteocytes) upon culture in induction medium. Both acute and partial obstruction of the bladder reduced expression of CD34 and changed localization of Sca-1 to the urothelium. Partial obstruction resulted in upregulation of fibrosis genes within the Sca-1+/CD34+/lin- population. Our data indicate a resident, mesenchymal stem cell population in the bladder that is altered by bladder obstruction. These findings provide new information about the cellular changes in the bladder that may be associated with bladder fibrosis. PMID:26540309

  4. The Murine Bladder Supports a Population of Stromal Sca-1+/CD34+/lin- Mesenchymal Stem Cells.

    PubMed

    Lilly, Meredith A; Kulkulka, Natalie A; Firmiss, Paula R; Ross, Michael J; Flum, Andrew S; Santos, Grace B Delos; Bowen, Diana K; Dettman, Robert W; Gong, Edward M

    2015-01-01

    Bladder fibrosis is an undesired end point of injury of obstruction and often renders the smooth muscle layer noncompliant. In many cases, the long-term effect of bladder fibrosis is renal failure. Despite our understanding of the progression of this disease, little is known about the cellular mechanisms that lead to a remodeled bladder wall. Resident stem (progenitor) cells have been identified in various organs such as the brain, heart and lung. These cells function normally during organ homeostasis, but become dysregulated after organ injury. Here, we aimed to characterize a mesenchymal progenitor cell population as a first step in understanding its role in bladder fibrosis. Using fluorescence activated cell sorting (FACS), we identified a Sca-1+/ CD34+/ lin- (PECAM-: CD45-: Ter119-) population in the adult murine bladder. These cells were localized to the stromal layer of the adult bladder and appeared by postnatal day 1. Cultured Sca-1+/ CD34+/ lin- bladder cells self-renewed, formed colonies and spontaneously differentiated into cells expressing smooth muscle genes. These cells differentiated into other mesenchymal lineages (chondrocytes, adipocytes and osteocytes) upon culture in induction medium. Both acute and partial obstruction of the bladder reduced expression of CD34 and changed localization of Sca-1 to the urothelium. Partial obstruction resulted in upregulation of fibrosis genes within the Sca-1+/CD34+/lin- population. Our data indicate a resident, mesenchymal stem cell population in the bladder that is altered by bladder obstruction. These findings provide new information about the cellular changes in the bladder that may be associated with bladder fibrosis. PMID:26540309

  5. The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.

    PubMed

    Aster, J C; Simms, W B; Zavala-Ruiz, Z; Patriub, V; North, C L; Blacklow, S C

    1999-04-13

    Notch1 is a member of a conserved family of large modular type 1 transmembrane receptors that control differentiation in multicellular animals. Notch function is mediated through a novel signal transduction pathway involving successive ligand-induced proteolytic cleavages that serve to release the intracellular domain of Notch, which then translocates to the nucleus and activates downstream transcription factors. The extracellular domain of all Notch receptors have three iterated LIN-12 modules that appear to act as negative regulatory domains, possibly by limiting proteolysis. Each LIN-12 module contains three disulfide bonds and three conserved aspartate (D) or asparagine (N) residues. To begin to understand the structural basis for LIN-12 function, the first LIN-12 module of human Notch1 (rLIN-12.1) has been expressed recombinantly in Escherichia coli and purified in a reduced form. In redox buffers, rLIN-12.1 forms only one disulfide isomer in the presence of millimolar Ca2+ concentrations, whereas multiple disulfide isomers are observed in the presence of Mg2+ and EDTA. Further, mutation of conserved residues N1460, D1475, and D1478 to alanine abolishes Ca2+-dependent folding of this module. Mass spectrometric analysis of partially reduced rLIN-12.1 has been used to deduce that disulfide bonds are formed between the first and fifth (C1449-C1472), second and fourth (C1454-C1467), and third and sixth (C1463-C1479) cysteines of this prototype module. This arrangement is distinct from that observed in other modules, such as EGF and LDL-A, that also contain three disulfide bonds. One-dimensional proton nuclear magnetic resonance shows that Ca2+ induces a dramatic increase in the extent of chemical shift dispersion of the native rLIN-12.1 amide protons, as seen for the Ca2+-binding LDL-A modules. We conclude that Ca2+ is required both for proper folding and for the maintenance of the structural integrity of Notch/LIN-12 modules.

  6. Letter to the editor of TAAP, in response to letter from Anders et al.

    EPA Science Inventory

    To the Editor, Toxicology and Applied Pharmacology: We would like to address the letter to the editor submitted by Anders et al. regarding the substantive issues raised regarding our paper "Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physi...

  7. Letters to the Editor: Public Writing as a Response to Reading.

    ERIC Educational Resources Information Center

    Rinehammer, Nora

    A study conducted by the copy editor of a small daily newspaper in Porter County, Indiana examines readers' motivations for writing letters to the editor. Analysis was based on letters that appeared in "The Vidette Messenger" September 16-30, 1992. Of 75 letters, 32 were responses to information published in the paper during the last 2 weeks. All…

  8. Magazine Article Placement: How Editors, Regular Contributors, and Novice Writers Rate Query Letters.

    ERIC Educational Resources Information Center

    Jolliffe, Lee

    About 350,000 freelance magazine articles were purchased by magazine editors last year from the 22,000 freelancers and 225,000 would-be freelancers in the United States. A study examined the factors editors judge most important in selecting freelance magazine article proposals, using factor analysis and qualitative examination of persuasive…

  9. Debunking the Mutilated Boy: A Study of Newspaper Editors and an Inflammatory Rumor.

    ERIC Educational Resources Information Center

    Brown, Lee

    A study examined how newspaper editors resolve issues relating to rumors--that is whether to cover stories which may turn out to be false. The "mutilated boy" rumor was chosen for its antiquity and endurance, its powerful theme, and its ability to create intense anxiety in a community. Thirty-three of the 86 editors who responded to the…

  10. New Technology and the Writer/Editor Relationship: Shifting Electronic Realities.

    ERIC Educational Resources Information Center

    Endres, Kathleen L.; Schierhorn, Ann B.

    1995-01-01

    Examines the role new technology is playing in the magazine writer/editor relationship. Finds that editors report the new technology is affecting their relationship with writers, and that free-lancers are less apt to use expensive new technology than staff writers. (SR)

  11. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Combination announcer, news editor and chief engineer. 793.11 Section 793.11 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT... editor and chief engineer. The 13(b)(9) exemption, as was made clear during the debate on the...

  12. "Clones," Codes, and Conflicts of Interest in Cartooning: Cartoonists and Editors Look at Ethics.

    ERIC Educational Resources Information Center

    Riffe, Daniel; And Others

    A study examined differences between political cartoonists and op-ed page editors on both traditional ethical issues (such as conflicts of interest) and the special, style-related concerns of editorial cartoonists. Hypotheses proposed were that editors and cartoonists (1) would condemn "cloning" or copying, reflecting an ethical principle…

  13. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9)...

  14. Adolescent Sexual Initiation through the Lens of Letters to the Editor Published in Polish Teenage Magazines

    ERIC Educational Resources Information Center

    Kopacz, Marek S.; Bajka-Kopacz, Aleksandra

    2012-01-01

    Almost all teenage magazines invite readers to submit questions concerning relationships, published as letters to the editor, popularly called "advice columns," often containing explicit questions about sexuality. This study aims to examine, firstly, how themes related to sexual initiation are presented in letters to the editor published in Polish…

  15. A "Situational" and "Coorientational" Measure of Specialized Magazine Editors' Perceptions of Readers.

    ERIC Educational Resources Information Center

    Jeffers, Dennis W.

    A study was undertaken of specialized magazine editors' perceptions of audience characteristics as well as the perceived role of their publications. Specifically, the study examines the relationship between the editors' perceptions of reader problem recognition, level of involvement, constraint recognition, and possession of reference criteria and…

  16. The Editor and Publisher as Public Official: The Ultimate Conflict of Interest.

    ERIC Educational Resources Information Center

    Sneed, Don

    A fifteen-item Likert scale and indepth personal interviews were used to collect data in a study that examined whether five individuals who held both the role of editor and public official were perceived as able to perform in a socially responsible manner as editors of their community newspapers in their estimation and in the estimation of a…

  17. The ceilometer inter-comparison campaign CeiLinEx2015

    NASA Astrophysics Data System (ADS)

    Mattis, Ina; Begbie, Robert; Boyouk, Neda; Bravo-Aranda, Juan Antonio; Brettle, Mike; Cermak, Jan; Drouin, Marc-Antoine; Geiß, Alexander; Görsdorf, Ulrich; Haefele, Alexander; Haeffelin, Martial; Hervo, Maxime; Komínková, Kateřina; Leinweber, Ronny; Müller, Gerhard; Münkel, Christoph; Pattantyús-Ábrahám, Margit; Pönitz, Kornelia; Wagner, Frank; Wiegner, Matthias

    2016-04-01

    Ceilometers are well established instruments for the detection of cloud base heights. Since about 2000, modern ceilometer types (mainly CHM15k, CL51, and CL31) are used also for investigations of the top height of the planetary boundary layer and for quantitative retrievals of vertical profiles of backscatter coefficients. In the framework of the European projects E-PROFILE and TOPROF, tools for the exchange of ceilometer data among European meteorological services, as well as calibration and visualization procedures are developed and established. Unfortunately, the national networks are equipped with instruments of different generations and different manufacturers. In order to quantify and reduce those inhomogeneities, the ceilometer inter-comparison experiment CeiLinEx2015 was performed between June and September 2015 at the Meteorological Observatory Lindenberg, Germany. We tested six different instrument types: LD40, CL31, CL51, CHM15k, CHM15kx, and CS135. Each instrument type was represented by two instruments to estimate the instrument-to-instrument variability and the influence of different firmware versions. Two Raman lidars (RAMSES and RALPH), operated by German Meteorological Service (DWD) are used as reference instruments. Further ancillary data are available, e.g., hourly eye observations, four radio soundings per day, and AERONET sun photometer observations. Beside the typical vertically pointing measurement scheme, we performed special measurements with horizontal pointing direction or blocked receiver telescope. During the experiment, we could collect measurements under very different meteorological situations: Several clear nights allow for Rayleigh-Calibration (see Hervo and CeiLinEx2015 team [EGU2016-4785]), a strong event of Sahara dust intrusion can be used to study the behaviour of the instruments in presence of large, non-spherical particles (like volcanic ash). Further investigations focus, e.g., on the detection of very low cloud base

  18. Quantitative analysis of substrate specificity of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26.

    PubMed

    Kmunícek, Jan; Hynková, Kamila; Jedlicka, Tomás; Nagata, Yuji; Negri, Ana; Gago, Federico; Wade, Rebecca C; Damborský, Jirí

    2005-03-01

    Haloalkane dehalogenases are microbial enzymes that cleave a carbon-halogen bond in halogenated compounds. The haloalkane dehalogenase LinB, isolated from Sphingomonas paucimobilis UT26, is a broad-specificity enzyme. Fifty-five halogenated aliphatic and cyclic hydrocarbons were tested for dehalogenation with the LinB enzyme. The compounds for testing were systematically selected using a statistical experimental design. Steady-state kinetic constants K(m) and k(cat) were determined for 25 substrates that showed detectable cleavage by the enzyme and low abiotic hydrolysis. Classical quantitative structure-activity relationships (QSARs) were used to correlate the kinetic constants with molecular descriptors and resulted in a model that explained 94% of the experimental data variability. The binding affinity of the tested substrates for this haloalkane dehalogenase correlated with hydrophobicity, molecular surface, dipole moment, and volume:surface ratio. Binding of the substrate molecules in the active site pocket of LinB depends nonlinearly on the size of the molecules. Binding affinity increases with increasing substrate size up to a chain length of six carbon atoms and then decreases. Comparative binding energy (COMBINE) analysis was then used to identify amino acid residues in LinB that modulate its substrate specificity. A model with three statistically significant principal components explained 95% of the experimental data variability. van der Waals interactions between substrate molecules and the enzyme dominated the COMBINE model, in agreement with the importance of substrate size in the classical QSAR model. Only a limited number of protein residues (6-8%) contribute significantly to the explanation of variability in binding affinities. The amino acid residues important for explaining variability in binding affinities are as follows: (i) first-shell residues Asn38, Asp108, Trp109, Glu132, Ile134, Phe143, Phe151, Phe169, Val173, Trp207, Pro208, Ile211, Leu248

  19. Molecular cloning and characterization of human WINS1 and mouse Wins2, homologous to Drosophila segment polarity gene Lines (Lin).

    PubMed

    Katoh, Masaru

    2002-08-01

    WNT signaling molecules play key roles in carcinogenesis and embryogenesis. Drosophila segment polarity gene Lines (Lin) is essential for Wnt/Wingless-dependent patterning in dorsal epidermis and also for hindgut development. With Wnt signaling, Lin accumulates in the nucleus to modulate transcription of Wnt target genes through association with beta-catenin/Armadillo and TCF/Pangolin. Here, human WINS1 and mouse Wins2, encoding proteins with Drosophila Lin homologous domain, were isolated using bioinformatics and cDNA-PCR. Human WINS1 encoded 757-amino-acid protein, and mouse Wins2 encoded 498-amino-acid protein. Human WINS1 and mouse Wins2 showed 60.0% total-amino-acid identity. Lin homologous domain of WINS1 and Wins2 showed 29.4% and 27.2% amino-acid identity with that of Drosphila Lin, respectively. In the human chromosome 15q26 region, WINS1 gene was clustered with ASB7 gene encoding ankyrin repeat and SOCS box-containing protein 7. Human WINS1 mRNA of 2.8-kb in size was expressed in adult testis, prostate, spleen, thymus, skeletal muscle, fetal kidney and brain. This is the first report on molecular cloning and initial characterization of human WINS1 and mouse Wins2 PMID:12119551

  20. Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

    SciTech Connect

    Sokolova, O.S.; Shaburova, O.V.; Pechnikova, E.V.; Shaytan, A.K.; Krylov, S.V.; Kiselev, N.A.; Krylov, V.N.

    2014-11-15

    A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body.

  1. Kinetic and Sequence-Structure-Function Analysis of LinB Enzyme Variants with β- and δ-Hexachlorocyclohexane

    PubMed Central

    Kumari, Kirti; Sharma, Pooja; Lal, Rup; Oakeshott, John G.; Pandey, Gunjan

    2014-01-01

    Organochlorine insecticide hexachlorocyclohexane (HCH) has recently been classified as a ‘Persistent Organic pollutant’ by the Stockholm Convention. The LinB haloalkane dehalogenase is a key upstream enzyme in the recently evolved Lin pathway for the catabolism of HCH in bacteria. Here we report a sequence-structure-function analysis of ten naturally occurring and thirteen synthetic mutants of LinB. One of the synthetic mutants was found to have ∼80 fold more activity for β- and δ-hexachlorocyclohexane. Based on detailed biophysical calculations, molecular dynamics and ensemble docking calculations, we propose that the latter variant is more active because of alterations to the shape of its active site and increased conformational plasticity. PMID:25076214

  2. New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.

    PubMed Central

    Thomas, Jeffrey H; Ceol, Craig J; Schwartz, Hillel T; Horvitz, H Robert

    2003-01-01

    Previous studies have shown that a synthetic multivulva phenotype results from mutations in genes that antagonize the ras-mediated intercellular signaling system responsible for vulval induction in Caenorhabditis elegans. Synthetic multivulva mutations define two classes of genes, A and B, and a mutation in a gene of each class is required to produce the multivulva phenotype. The ectopic vulval tissue in multivulva animals is generated by vulval precursor cells that in the wild type do not generate vulval tissue. One of the class B synthetic multivulva genes, lin-35, encodes a protein similar to the retinoblastoma (Rb) protein. In this article, we describe the isolation and characterization of 50 synthetic multivulva mutations, the identification of new components of both the class A and class B lin-35 Rb pathways, and the cloning of lin-52, a class B gene that may have a conserved role in Rb-mediated signaling. PMID:12750327

  3. THE NEW ONLINE METADATA EDITOR FOR GENERATING STRUCTURED METADATA

    SciTech Connect

    Devarakonda, Ranjeet; Shrestha, Biva; Palanisamy, Giri; Hook, Leslie A; Killeffer, Terri S; Boden, Thomas A; Cook, Robert B; Zolly, Lisa; Hutchison, Viv; Frame, Mike; Cialella, Alice; Lazer, Kathy

    2014-01-01

    Nobody is better suited to describe data than the scientist who created it. This description about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset [1]. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, and locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [2][4]. OME is part of ORNL s Mercury software fleet [2][3]. It was jointly developed to support projects funded by the United States Geological Survey (USGS), U.S. Department of Energy (DOE), National Aeronautics and Space Administration (NASA) and National Oceanic and Atmospheric Administration (NOAA). OME s architecture provides a customizable interface to support project-specific requirements. Using this new architecture, the ORNL team developed OME instances for USGS s Core Science Analytics, Synthesis, and Libraries (CSAS&L), DOE s Next Generation Ecosystem Experiments (NGEE) and Atmospheric Radiation Measurement (ARM) Program, and the international Surface Ocean Carbon Dioxide ATlas (SOCAT). Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. From the information on the form, the Metadata Editor can create an XML file on the server that the editor is installed or to the user s personal computer. Researchers can also use the ORNL Metadata Editor to modify existing XML metadata files. As an example, an NGEE Arctic scientist use OME to register

  4. The Best Stylists: A Survey of Editors, and Implications for the Teaching of Style in Freshman Composition Courses.

    ERIC Educational Resources Information Center

    Spigelmire, Lynne

    A survey of 112 editors from magazines, newspapers, and publishing houses was conducted to obtain their judgments about prose style, the best prose stylists, and representative works by those stylists. Of the 112 editors surveyed, only 22 responded with useful data. The results indicated very little consensus among editors, and almost no…

  5. The New Online Metadata Editor for Generating Structured Metadata

    NASA Astrophysics Data System (ADS)

    Devarakonda, R.; Shrestha, B.; Palanisamy, G.; Hook, L.; Killeffer, T.; Boden, T.; Cook, R. B.; Zolly, L.; Hutchison, V.; Frame, M. T.; Cialella, A. T.; Lazer, K.

    2014-12-01

    Nobody is better suited to "describe" data than the scientist who created it. This "description" about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, and locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [1] [2]. Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. How is OME helping Big Data Centers like ORNL DAAC? The ORNL DAAC is one of NASA's Earth Observing System Data and Information System (EOSDIS) data centers managed by the ESDIS Project. The ORNL DAAC archives data produced by NASA's Terrestrial Ecology Program. The DAAC provides data and information relevant to biogeochemical dynamics, ecological data, and environmental processes, critical for understanding the dynamics relating to the biological components of the Earth's environment. Typically data produced, archived and analyzed is at a scale of multiple petabytes, which makes the discoverability of the data very challenging. Without proper metadata associated with the data, it is difficult to find the data you are looking for and equally difficult to use and understand the data. OME will allow data centers like the ORNL DAAC to produce meaningful, high quality, standards-based, descriptive information about their data products in-turn helping with the data discoverability and

  6. COMBINED ENDOCRINE EFFECTS OF IN UTERO EXPOSURE TO THE ANTIANDROGENS BUTYLBENZYL PHTHALATE (BBP) AND LINURON (LIN) ON FETAL TESTOSTERONE (T) SYNTHESIS AND REPRODUCTIVE TRACT DEVELOPMENT

    EPA Science Inventory

    COMBINED ENDOCRINE EFFECTS OF IN UTERO EXPOSURE TO THE ANTIANDROGENS BUTYLBENZYL PHTHALATE (BBP) AND LINURON (Lin) ON FETAL TESTOSTERONE (T) SYNTHESIS AND REPRODUCTIVE TRACT DEVELOPMENT
    Parks LG , Hotchkiss AK, Ostby J, Lambright C and Gray LE, Jr.

    Lin and BBP are toxic...

  7. Training the unseasoned technical writer-editor: From the trainee's perspective

    SciTech Connect

    Gibbs, B.R.

    1991-01-01

    Many unseasoned technical writer-editors who are not adequately trained may become seasoned inadequately trained technical writer-editors. This problem can occur when a trainee is involved in an ineffective training program, but it can be alleviated by the trainer's assessing the unseasoned writer's talents, becoming involved with the trainee's growth in writing and editing skills, and helping him to visualize his potential as a technical writer-editor. Assessment, support, mentoring, and nurturing are important elements in the trainee's growth process and in any good training or internship program. 1 ref.

  8. [Zheng Yu-lin, a founder of the acupuncture and moxibustion cause of new China].

    PubMed

    Tian, Da-zhe; Liu, Jun-chi; Zhao, Juan; Zheng, Jun-jiang

    2007-07-01

    Mr. ZHENG Yu-lin is one of the most outstanding acupuncture scientists in the modern times in our country. He inherits the learning handed down in a family and is bold in making innovations, successfully combines the exercises to benefit the internal organs with Chinese traditional acupuncture needling methods, forming a set of unique Zheng's needling methods, which is used for treatment of severe ophthalmopathy with excellent therapeutic effects, and is famed the world over. Main achievements: took on scientific researches of acupuncture and moxibustion, teaching and clinical works in the first stage of establishment of China Academy of Traditional Chinese Medicinel trains a large number of famous specificities of acupuncture and moxibustion for new China; advocates study on channel essence; cures stubborn diseases for leaders of friend countries undertaking the great trust of the central leaders for many times, becoming an important ties of Chinese political foreign affairs. PMID:17722840

  9. Science publishing: A day in the life of an APS editor

    NASA Astrophysics Data System (ADS)

    Thomas, Katherine

    2015-03-01

    I will share my experience in working as an editor for a scholarly journal. The talk will include information on my career path, the skills and qualifications needed, and give insight into my day-to-day activities

  10. Quantitative Silencing of EGFP Reporter Gene by Self-Assembled siRNA Lipoplexes of LinOS and Cholesterol

    PubMed Central

    2012-01-01

    Nonviral siRNA vectors prepared by the direct mixing of siRNA and mixtures of an asymmetric N4,N9-diacyl spermine conjugate, N4-linoleoyl-N9-oleoyl-1,12-diamino-4,9-diazadodecane (LinOS), with either cholesterol or DOPE, at various molar ratios of the neutral lipids, are reported. The effects of varying the lipid formulation and changing the N/P charge ratio on the intracellular delivery of siRNA to HeLa cells and on the siRNA-mediated gene silencing of a stably expressed reporter gene (EGFP) were evaluated. The presence of either cholesterol or DOPE in the mixture resulted in a marked increase in the delivery of the siRNA as well as enhanced EGFP silencing as evaluated by FACS. A LinOS/Chol 1:2 mixture resulted in the highest siRNA delivery and the most efficient EGFP silencing (reduced to 20%) at N/P = 3.0. Lowering the amount of siRNA from 15 pmol to 3.75 pmol, thus increasing the N/P charge ratio to 11.9, resulted in decreasing the amount of delivered siRNA, while the efficiency of gene silencing was comparable to that obtained with 15 pmol (N/P = 3.0) of siRNA. Mixtures of symmetrical N4,N9-dioleoyl spermine (DOS) with cholesterol at 1:2 molar ratio showed less siRNA delivery than with LinOS/Chol at N/P = 3.0 (15 pmol of siRNA), and comparable delivery at N/P = 11.9 (3.75 pmol of siRNA). The EGFP silencing was comparable with LinOS and with DOS when mixed with cholesterol 1:2 (lipoplexes prepared with 15 pmol of siRNA), but LinOS mixtures showed better EGFP silencing when the siRNA was reduced to 3.75 pmol. Lipoplex particle size determination by DLS of cholesterol mixtures was 106–118 nm, compared to 194–356 nm for lipoplexes prepared with the spermine conjugates only, and to 685 nm for the LinOS/DOPE 1:1 mixture. Confocal microscopy showed successful siRNA delivery of red tagged siRNA and quantitative EGFP knockdown in HeLa EGFP cells; Z-stack photomicrographs showed that the delivered siRNA is distributed intracellularly. Cryo-TEM of siRNA LinOS/Chol 1

  11. Alternatives for improved safety in storage and handling of LOX and LIN

    NASA Astrophysics Data System (ADS)

    Schmauch, G. E.; Peters, G. A.

    The industrial gas industry has experienced favourable safety performance in the storage and handling of cryogenic liquids. In recent years, however, there have been increasing challenges to further reduce the risk to employees, customers and the public from inadvertent spills and releases of LOX and LIN. With large flat-bottom storage tanks, serious spills or releases can result from external liquid piping damage or valve failure, tank overpressurization to the point of failure and overfill beyond the maximum safe liquid levels. This paper demonstrates by fault tree analysis the benefits of internal shut-off valves for spill prevention. It describes the risk reduction obtained by multiple pressure relief devices for prevention of overpressure failure of the tank. Overfill hazards are also described and quantified. With over-the-road LOX and LIN tanker loading, serious spills and releases can result from tanker pull-away during loading and from tanker overfill. Pull-away prevention/protection systems are discussed. A precision loading system to regulate the maximum load in tankers at or slightly below the road weight limit is described and its benefits as a hazardous overfill and spill protection system are quantified. Malfunction of cryogenic liquid vaporizer systems can lead to effluent temperatures that challenge the low temperature integrity of non-cryogenic downstream piping. The benefits of redundant low temperature monitors and flow shut-off systems as protection against piping failure and uncontrolled releases are demonstrated by fault tree analysis. While these systems focus on spill and release prevention or frequency reduction, the use of liquid retention systems such as curbs, gutters, sumps and dikes are briefly discussed, along with vapour barriers for vapour retention, as techniques for consequence reduction.

  12. XSHOOTER spectroscopy of the enigmatic planetary nebula Lin49 in the Small Magellanic Cloud

    NASA Astrophysics Data System (ADS)

    Otsuka, Masaaki; Kemper, F.; Leal-Ferreira, M. L.; Aleman, I.; Bernard-Salas, J.; Cami, J.; Ochsendorf, B. B.; Peeters, E.; Scicluna, P.

    2016-10-01

    We performed a detailed spectroscopic analysis of the fullerene C60-containing planetary nebula (PN) Lin49 in the Small Magellanic Cloud (SMC) using XSHOOTER at the European Southern Observatory Very Large Telescope and the Spitzer/Infrared Spectrograph instruments. We derived nebular abundances for nine elements. We used TLUSTY to derive photospheric parameters for the central star. Lin49 is C-rich and metal-deficient PN (Z ˜ 0.0006). The nebular abundances are in good agreement with asymptotic giant branch nucleosynthesis models for stars with initial mass 1.25 M⊙ and metallicity Z = 0.001. Using the TLUSTY synthetic spectrum of the central star to define the heating and ionizing source, we constructed the photoionization model with CLOUDY that matches the observed spectral energy distribution (SED) and the line fluxes in the UV to far-IR wavelength ranges simultaneously. We could not fit the ˜1-5 μm SED using a model with 0.005-0.1-μm-sized graphite grains and a constant hydrogen density shell owing to the prominent near-IR excess, while at other wavelengths the model fits the observed values reasonably well. We argue that the near-IR excess might indicate either (1) the presence of very small particles in the form of small carbon clusters, small graphite sheets, or fullerene precursors, or (2) the presence of a high-density structure surrounding the central star. We found that SMC C60 PNe show a near-IR excess component to lesser or greater degree. This suggests that these C60 PNe might maintain a structure nearby their central star.

  13. Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.

    PubMed Central

    1994-01-01

    In the 13 years since it was first published the "Uniform requirements for manuscripts submitted to biomedical journals" (the Vancouver style), developed by the International Committee of Medical Journal Editors, has been widely accepted by both authors and editors; over 400 journals have stated that they will consider manuscripts that conform to its requirements. This is the fourth edition of the "Uniform requirements." PMID:8287338

  14. [Analysis of acid rain characteristics of Lin'an Regional Background Station using long-term observation data].

    PubMed

    Li, Zheng-Quan; Ma, Hao; Mao, Yu-Ding; Feng, Tao

    2014-02-01

    Using long-term observation data of acid rain at Lin'an Regional Background Station (Lin'an RBS), this paper studied the interannual and monthly variations of acid rain, the reasons for the variations, and the relationships between acid rain and meteorological factors. The results showed that interannual variation of acid rain at Lin'an RBS had a general increasing trend in which there were two obvious intensifying processes and two distinct weakening processes, during the period ranging from 1985 to 2012. In last two decades, the monthly variation of acid rain at Lin'an RBS indicated that rain acidity and frequency of severe acid rain were increasing but the frequency of weak acid rain was decreasing when moving towards bilateral side months of July. Acid rain occurrence was affected by rainfall intensity, wind speed and wind direction. High frequency of severe acid rain and low frequency of weak acid rain were on days with drizzle, but high frequency of weak acid rain and low frequency of severe acid rain occurred on rainstorm days. With wind speed upgrading, the frequency of acid rain and the proportion of severe acid rain were declining, the pH value of precipitation was reducing too. Another character is that daily dominant wind direction of weak acid rain majorly converged in S-W section ,however that of severe acid rain was more likely distributed in N-E section. The monthly variation of acid rain at Lin'an RBS was mainly attributed to precipitation variation, the increasing and decreasing of monthly incoming wind from SSE-WSW and NWN-ENE sections of wind direction. The interannual variation of acid rain could be due to the effects of energy consumption raising and significant green policies conducted in Zhejiang, Jiangsu and Shanghai.

  15. [Analysis of acid rain characteristics of Lin'an Regional Background Station using long-term observation data].

    PubMed

    Li, Zheng-Quan; Ma, Hao; Mao, Yu-Ding; Feng, Tao

    2014-02-01

    Using long-term observation data of acid rain at Lin'an Regional Background Station (Lin'an RBS), this paper studied the interannual and monthly variations of acid rain, the reasons for the variations, and the relationships between acid rain and meteorological factors. The results showed that interannual variation of acid rain at Lin'an RBS had a general increasing trend in which there were two obvious intensifying processes and two distinct weakening processes, during the period ranging from 1985 to 2012. In last two decades, the monthly variation of acid rain at Lin'an RBS indicated that rain acidity and frequency of severe acid rain were increasing but the frequency of weak acid rain was decreasing when moving towards bilateral side months of July. Acid rain occurrence was affected by rainfall intensity, wind speed and wind direction. High frequency of severe acid rain and low frequency of weak acid rain were on days with drizzle, but high frequency of weak acid rain and low frequency of severe acid rain occurred on rainstorm days. With wind speed upgrading, the frequency of acid rain and the proportion of severe acid rain were declining, the pH value of precipitation was reducing too. Another character is that daily dominant wind direction of weak acid rain majorly converged in S-W section ,however that of severe acid rain was more likely distributed in N-E section. The monthly variation of acid rain at Lin'an RBS was mainly attributed to precipitation variation, the increasing and decreasing of monthly incoming wind from SSE-WSW and NWN-ENE sections of wind direction. The interannual variation of acid rain could be due to the effects of energy consumption raising and significant green policies conducted in Zhejiang, Jiangsu and Shanghai. PMID:24812937

  16. EDITORIAL: Message from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Dendy, R.

    2005-01-01

    On 1 January 2005 I become Editor-in-Chief of Plasma Physics and Controlled Fusion. I look forward to assisting contributors, referees and the Board in maintaining the high standards of this international journal, whose bibliometric impact factor has consistently matched or exceeded that of other journals in the field. The robust, good health of Plasma Physics and Controlled Fusion reflects that of its user communities. With a decision to proceed to the construction of ITER apparently imminent, magnetic confinement fusion research is preparing to take a major step forwards. A new generation of laser-plasma interaction facilities for inertial fusion research is also rising at key sites around the world. Technical progress in our field is underpinned by scientific excellence, and the publication of results in Plasma Physics and Controlled Fusion will, I hope, continue to play its part. The journal will continue to offer the benefits of refereeing by two experts, combined with the rapid turnaround achieved by the highly efficient editorial office at the Institute of Physics Publishing in Bristol. Looking elsewhere, there may be opportunities for gentle incremental broadening of the scientific scope of the journal, in the medium term. One looks in particular to those branches of plasma physics that, in recent years, have become more strongly represented in the series of conferences organized by the Plasma Physics Division of the European Physical Society. The recent special issue of Plasma Physics and Controlled Fusion (Plasma Phys. Control. Fusion 46 (2004) B1--592) provides an indication. Finally, it is a pleasure to thank my predecessor, Professor Ian Hutchinson of the Massachusetts Institute of Technology, for handing on his role with the journal in such promising condition.

  17. Report of the world association of medical editors: agenda for the future.

    PubMed

    2001-04-01

    During a 3-day meeting at Bellagio in January 2001, a group of 20 editors from 12 countries in 5 continents met to map out a strategy for the World Association of Medical Editors (WAME)'s continued development in the service of medical editors over the next several years. The group: 1) Developed a statement of principles on the standards of professionalism and responsibilities of editors (this statement will be posted on the Web site after electronic consultation with and comment by WAME editors); 2) Agreed to assess the extent to which these principles are reflected in practice and to explore barriers to their adoption, using data from a survey and focus groups; 3) Developed and outlined an on-line program for distance learning, targeted at new editors; 4) Planned for formal evaluation of the educational outreach program; and 5) Agreed to support regional initiatives to strengthen local editorial capacity. Underpinning all past and proposed future activities is the WAME Web site. The ambitious plans outlined above will require extensive development of the site, plans for which were made at the Bellagio meeting.

  18. A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans.

    PubMed

    Stefani, Giovanni; Chen, Xiaowei; Zhao, Hongyu; Slack, Frank J

    2015-05-01

    The evolutionarily conserved gene lin-28 encodes an RNA-binding protein and is an important regulator of the proper temporal succession of several developmental events in both invertebrates and vertebrates. At the cellular level, LIN-28 promotes stemness and proliferation, and inhibits differentiation, a feature best illustrated by its ability to induce pluripotency when ectopically expressed in human fibroblasts in combination with NANOG, OCT4, and SOX2. Mammalian LIN28 functions in part by regulating processing of the let-7 microRNA through a GGAG binding site in the pre-let-7's distal loop region. However, many human and animal let-7 precursors lack the GGAG binding motif. In order to dissect the molecular mechanisms underlying its biological functions in a living animal, we identified a map of LIN-28 interactions with the transcriptome by in vivo HITS-CLIP in Caenorhabditis elegans. LIN-28 binds a large pool of messenger RNAs, and a substantial fraction of the bona fide LIN-28 targets are involved in aspects of animal development. Furthermore, our data show that LIN-28 regulates the expression of the let-7 microRNA by binding its primary transcript in a previously unknown region, revealing a novel regulatory mechanism.

  19. Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts

    PubMed Central

    Byrnes, Colleen; Kaushal, Megha; Rabel, Antoinette; Tumburu, Laxminath; Allwardt, Joshua M.; Miller, Jeffery L.

    2015-01-01

    Increasing fetal hemoglobin (HbF) levels in adult humans remains an active area in hematologic research. Here we explored erythroid-specific LIN28A expression for its effect in regulating gamma-globin gene expression and HbF levels in cultured adult erythroblasts. For this purpose, lentiviral transduction vectors were produced with LIN28A expression driven by erythroid-specific gene promoter regions of the human KLF1 or SPTA1 genes. Transgene expression of LIN28A with a linked puromycin resistance marker was restricted to the erythroid lineage as demonstrated by selective survival of erythroid colonies (greater than 95% of all colonies). Erythroblast LIN28A over-expression (LIN28A-OE) did not significantly affect proliferation or inhibit differentiation. Greater than 70% suppression of total let-7 microRNA levels was confirmed in LIN28A-OE cells. Increases in gamma-globin mRNA and protein expression with HbF levels reaching 30–40% were achieved. These data suggest that erythroblast targeting of LIN28A expression is sufficient for increasing fetal hemoglobin expression in adult human erythroblasts. PMID:26675483

  20. A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans

    PubMed Central

    Stefani, Giovanni; Chen, Xiaowei; Zhao, Hongyu; Slack, Frank J.

    2015-01-01

    The evolutionarily conserved gene lin-28 encodes an RNA-binding protein and is an important regulator of the proper temporal succession of several developmental events in both invertebrates and vertebrates. At the cellular level, LIN-28 promotes stemness and proliferation, and inhibits differentiation, a feature best illustrated by its ability to induce pluripotency when ectopically expressed in human fibroblasts in combination with NANOG, OCT4, and SOX2. Mammalian LIN28 functions in part by regulating processing of the let-7 microRNA through a GGAG binding site in the pre-let-7’s distal loop region. However, many human and animal let-7 precursors lack the GGAG binding motif. In order to dissect the molecular mechanisms underlying its biological functions in a living animal, we identified a map of LIN-28 interactions with the transcriptome by in vivo HITS-CLIP in Caenorhabditis elegans. LIN-28 binds a large pool of messenger RNAs, and a substantial fraction of the bona fide LIN-28 targets are involved in aspects of animal development. Furthermore, our data show that LIN-28 regulates the expression of the let-7 microRNA by binding its primary transcript in a previously unknown region, revealing a novel regulatory mechanism. PMID:25805859

  1. LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo

    PubMed Central

    Lee, Y. Terry; de Vasconcellos, Jaira F.; Yuan, Joan; Byrnes, Colleen; Noh, Seung-Jae; Meier, Emily R.; Kim, Ki Soon; Rabel, Antoinette; Kaushal, Megha; Muljo, Stefan A.

    2013-01-01

    Reactivation of fetal hemoglobin (HbF) holds therapeutic potential for sickle cell disease and β-thalassemias. In human erythroid cells and hematopoietic organs, LIN28B and its targeted let-7 microRNA family, demonstrate regulated expression during the fetal-to-adult developmental transition. To explore the effects of LIN28B in human erythroid cell development, lentiviral transduction was used to knockdown LIN28B expression in erythroblasts cultured from human umbilical cord CD34+ cells. The subsequent reduction in LIN28B expression caused increased expression of let-7 and significantly reduced HbF expression. Conversely, LIN28B overexpression in cultured adult erythroblasts reduced the expression of let-7 and significantly increased HbF expression. Cellular maturation was maintained including enucleation. LIN28B expression in adult erythroblasts increased the expression of γ-globin, and the HbF content of the cells rose to levels >30% of their hemoglobin. Expression of carbonic anhydrase I, glucosaminyl (N-acetyl) transferase 2, and miR-96 (three additional genes marking the transition from fetal-to-adult erythropoiesis) were reduced by LIN28B expression. The transcription factor BCL11A, a well-characterized repressor of γ-globin expression, was significantly down-regulated. Independent of LIN28B, experimental suppression of let-7 also reduced BCL11A expression and significantly increased HbF expression. LIN28B expression regulates HbF levels and causes adult human erythroblasts to differentiate with a more fetal-like phenotype. PMID:23798711

  2. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Gardner, Jason S.

    2012-01-01

    As I begin my tenure as Editor-in-Chief of Journal of Physics: Condensed Matter (JPCM), I look upon this opportunity as both an honour and a real challenge. The journal is in great shape thanks to the work of my predecessors, Marshall Stoneham and David Ferry. The journal's solid reputation is based largely on the work these gentlemen have done over the past decade. The other main reason for the success of JPCM is the amazing staff in Bristol; keep up the good work, please. When discussing the journal with scientists from all corners of the globe, one thing is always mentioned—JPCM is a very reliable journal with well-written, high-quality papers, and a fast but rigorous peer-review process that provides fair, detailed and constructive referee reports for the benefit of authors. This is due almost entirely to our great authors and referees; we rely on them every day—thank you. As the new Editor-in-Chief I hope to continue to improve still further the journal's status in condensed matter science. As mentioned above, our reputation is excellent, but the reality is that we live in a world of bibliometrics and rankings. Over the past few years JPCM has been repositioned as a journal at the forefront of condensed matter physics, and the impact of the journal should increase further as a result of continued emphasis on commissioning in cutting-edge areas identified by the Editorial Board and the journal team. In addition to regular papers, JPCM has a number of other content streams that authors and readers can benefit from. Fast track communications (FTCs) offer exceptionally fast publication for work of the highest impact and urgency. By their select nature, FTCs benefit from personal treatment by the Editorial Board and the average receipt-to-first-decision time is just 11 days (the average receipt-to-publication time is just 45 days). Topical reviews in JPCM make the journal one of the most authoritative sources of review content for condensed matter physics

  3. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Corkum, Paul

    2011-01-01

    As a journal that reports advances in atomic, molecular and optical science (AMO), Journal of Physics B: Atomic, Molecular and Optical Physics (J. Phys. B) provides the AMO research community with three unique fora: topical reviews, tutorials and special issues. Developed under the leadership of editor Jan Michael Rost and his Editorial Board, these sections have cemented J. Phys. B's reputation as a major journal showcasing the AMO community's advances. For me, an AMO scientist, it is therefore a special pleasure to be entrusted with continuing the tradition of excellence established by Jan Michael and the Editorial Board. I intend to build on this foundation by ensuring that the journal makes full use of these tools. Topical reviews: a unique focus When J. Phys. B becomes the first journal you turn to for initial reviews about important emerging areas in your field, we as an Editorial Board will have succeeded. To us, a topical review is different from a traditional review—a topical review focuses on emerging sub-fields of AMO physics. Its function is to alert and educate our readers about emerging opportunities. Topical reviews can also serve a closely related function for readers: keeping us up-to-date with critical technologies that lie slightly outside our own fields, such as advances in free-electron lasers science, (which will surely affect our field). Our overall goal is to make your research more productive because of the topical reviews you read within the journal. Tutorials J. Phys. B tutorials are aimed at graduate students or researchers venturing into a new field. Just as in my own research group I encourage all graduate students to write their theses in a way that will be useful to both future graduate students and the larger community beyond my group, J. Phys. B has designed tutorials to fill this function on the journal scale. Thus, tutorial authors are able to write in greater depth than can be included in a paper in nature, science or in the

  4. Lin28a Protects against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis by Alleviating Mitochondrial Dysfunction under High Glucose/High Fat Conditions

    PubMed Central

    Hu, Jianqiang; Yuan, Yuan; Sun, Shuhong; Wang, Jiaxing; Yu, Wenjun; Wang, Chen; Sun, Dongdong; Wang, Haichang

    2014-01-01

    Aim The aim of the present study was to investigate the role of Lin28a in protecting against hypoxia/reoxygenation (H/R)-induced cardiomyocytes apoptosis under high glucose/high fat (HG/HF) conditions. Methods Primary cardiomyocytes which were isolated from neonatal mouse were randomized to be treated with lentivirus carrying Lin28a siRNA, Lin28acDNA 72 h before H/R (9 h/2 h). Cardiomyocytes biomarkers release (LDH and CK), cardiomyocytes apoptosis, mitochondria biogenesis and morphology, intracellular reactive oxygen species (ROS) production, ATP content and inflammatory cytokines levels after H/R injury in high glucose/high fat conditions were compared between groups. The target proteins of Lin28a were examined by western blot analysis. Results Our results revealed that Lin28a cDNA transfection (overexpression) significantly inhibited cardiomyocyte apoptotic index, improved mitochondria biogenesis, increased ATP production and reduced ROS production as compared with the H/R group in HG/HF conditions. Lin28a siRNA transfection (knockdown) rendered the cardiomyocytes more susceptible to H/R injury as evidenced by increased apoptotic index, impaired mitochondrial biogenesis, decreased ATP production and increased ROS level. Interestingly, these effects of Lin28a were blocked by pretreatment with the PI3K inhibitor wortmannin. Lin28a overexpression increased, while Lin28a knockdown inhibited IGF1R, Nrf-1, Tfam, p-IRS-1, p-Akt, p-mTOR, p-p70s6k, p-AMPK expression levels after H/R injury in HG/HF conditions. Moreover, pretreatment with wortmannin abolished the effects of Lin28a on the expression levels of p-AKT, p-mTOR, p-p70s6k, p-AMPK. Conclusions The present results suggest that Lin28a inhibits cardiomyocytes apoptosis by enhancing mitochondrial biogenesis and function under high glucose/high fat conditions. The mechanism responsible for the effects of Lin28a is associated with the PI3K/Akt dependent pathway. PMID:25313561

  5. EDITORIAL: Thank you and farewell from the Founding Editor

    NASA Astrophysics Data System (ADS)

    Baskes, Mike

    2005-07-01

    I have been involved with Modelling and Simulation in Materials Science and Engineering (MSMSE) from the very beginning when it was merely an idea, over 14 years ago, to the current journal that is well supported by the community. During my time as Editor there have been many changes in the journal, including the introduction of electronic submissions, web-based services and free printed colour where it is essential to the article, as well as completely free colour online. The journal has seen excellent growth in the number and quality of submissions and the number of articles published continues to rise, enabling us to expand the journal to eight issues in 2005. Web accesses and downloads have greatly surpassed even my wildest dreams. In my opinion, the emergence of MSMSE as a top materials modelling journal has confirmed the vision of Institute of Physics Publishing (IOPP) and the Executive Board that this area of science and engineering was ripe for a specialized journal. I feel that, having seen the journal through the early years and watched it grow into a successful arena for multidisciplinary materials research, it is now an appropriate time for me to hand over the reins. The journal has a great foundation for future growth and development and is supported by an excellent Editorial Board, who have given me a great deal of help and advice over the years. I feel sure that they will continue to support the journal when Bill Curtin, Brown University, takes over on 1 July 2005. Bill has the diverse experience in modelling at the atomic, dislocation, and continuum levels to lead the journal to new heights. Finally I would like to thank all of the readers, authors and referees who have greatly contributed to MSMSE over the years. Thank you for your support and help, and I hope you will continue to support the journal. Last, but not least, I would like to thank the staff at IOPP. Without their expert assistance, the journal could not have been as successful as it is

  6. CHAIRMEN'S PREFACE AND EDITORS' NOTE: Unification of Fundamental Interactions

    NASA Astrophysics Data System (ADS)

    Brink, Lars; Nilsson, Jan S.; Salomonson, Per; Skagerstam, Bo-Sture

    1987-01-01

    Vainshtein. We had hoped that the Nobel Symposium should be a signal for improved relations between East and West, but in this respect we failed. The Symposium was held in the small town of Marstrand, a summer resort on an island outside Göteborg. The idea was to have it relatively close to home and to show the participants perhaps the best part of the local nature. Another motive was to keep the participants semi-isolated to provide ample time for discussions. With the somewhat heavy programme we found that even so, the days were not long enough. This Symposium was the second Nobel Symposium on elementary particle physics. The first one, also organized by our group, was held in 1968. We hope and believe that the next one need not be awaited another 18 years! The Symposium was made possible by a generous grant from the Nobel Foundation. An additional grant from the Royal Swedish Academy of Sciences was also essential. A grant from Nordita made it possible to invite some ten Nordic observers. We also gratefully acknowledge help with the organization of the Symposium from the city of Goteborg, the city of Kungälv, Volvo, Skandinaviska Enskilda banken, Ericsson AB and IBM Sweden. We thank all the participants for all their efforts, to come to our remote part of the world, to give excellent talks, to write up their talks astonishingly quickly and to share with us so much of their knowledge and expertise. Last but not least we are indebted to the members of the organizing committee, members of the group and the secretarial staff. Goteborg, August 1986 Editors' NoteIn these Proceedings the lectures are given in the order of their oral presentation at the Symposium. Regrettably, a few contributors could not participate (V. Gribov, A. Linde, V. Ogievetsky, M. Shifman and A. M. Polyakov). Their contributions have been placed close to the end of the Proceedings. As these authors did not have the opportunity of correcting the proofs, responsibility for printing errors must rest with

  7. The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.

    PubMed

    Chen, Ning; Greenwald, Iva

    2004-02-01

    The vulval precursor cells (VPCs) are spatially patterned by a LET-23/EGF receptor-mediated inductive signal and a LIN-12/Notch-mediated lateral signal. The lateral signal has eluded identification, so the mechanism by which lateral signaling is activated has not been known. Here, we computationally identify ten genes that encode potential ligands for LIN-12, and show that three of these genes, apx-1, dsl-1, and lag-2, are functionally redundant components of the lateral signal. We also show that transcription of all three genes is initiated or upregulated in VPCs in response to inductive signaling, suggesting that direct transcriptional control of the lateral signal by the inductive signal is part of the mechanism by which these cell signaling events are coordinated. In addition, we show that DSL-1, which lacks a predicted transmembrane domain, is a natural secreted ligand and can substitute for the transmembrane ligand LAG-2 in different functional assays.

  8. US health journal editors' opinions and policies on research in race, ethnicity, and health.

    PubMed

    Bennett, T; Bhopal, R

    1998-07-01

    Health research on race and ethnicity has been criticized for lacking rigor in conceptualization, terminology, and analysis. Scientific journals' editorial processes help determine research quality. This survey assessed editors' awareness of current debates, attitudes toward recent recommendations, and involvement in developing editorial policies. Twenty-nine editors of health journals with impact factors of > or = 1 (based on citation ratings) were sent a questionnaire including four key problems identified in research literature and recommendations from federal agencies; 23 (79%) responded. Seven editors relevant policies. Two had read the federal directive on racial and ethnic classification; one was aware of its current review. Most perceived the four key problems as uncommon. The majority agreed with Public Health Service recommendations on race and ethnicity research, except for analyzing effects of racism. Approximately 20% had discussed issues with co-editors, editorial boards, or reviewers. About 40% saw further discussion as beneficial; four planned to draft guidelines. Editors' potential for helping resolve problems in race/ethnicity research is not being realized. Greater participation would be beneficial to public health research and practice.

  9. [The relevance of the International Committee of Medical Journal Editors (ICMJE) for medical publishing and research].

    PubMed

    Reyes, Humberto B

    2014-01-01

    The International Committee of Medical Journal Editors is a leading independent institution providing guidance for the report of biomedical research and health related topics in medical journals. Established in 1978, it is currently constituted by editors of fourteen general medical journals from different countries, plus one representative for the US National Library of Medicine and one representative for the World Association of Biomedical Journal Editors. Since 1978 the Committee provides a document, originally named "Uniform Requirements…", "to help authors, editors, and others involved in peer review and biomedical publishing create and distribute accurate, clear, unbiased medical journal articles". This document has been updated several times and the last version was released in August 2013, now renamed "Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals", available in www.icmje.org and citable as "ICMJE Recommendations". A vast proportion of medical journals, worldwide, have adopted these recommendations as rules. The ICMJE discusses and provides guidance on several relevant aspects including criteria on authorship, peer review, scientific misconduct, conflicts of interest, clinical trials registration, good editorial practices, the relations between editors and journal owners, the protection of individuals subject to medical research, the solvency of electronic publications, among others. The 2013 ICMJE Annual Meeting took place in Santiago, Chile, in November 4 and 5. The photograph shows attendants to the final session.

  10. US health journal editors' opinions and policies on research in race, ethnicity, and health.

    PubMed Central

    Bennett, T.; Bhopal, R.

    1998-01-01

    Health research on race and ethnicity has been criticized for lacking rigor in conceptualization, terminology, and analysis. Scientific journals' editorial processes help determine research quality. This survey assessed editors' awareness of current debates, attitudes toward recent recommendations, and involvement in developing editorial policies. Twenty-nine editors of health journals with impact factors of > or = 1 (based on citation ratings) were sent a questionnaire including four key problems identified in research literature and recommendations from federal agencies; 23 (79%) responded. Seven editors relevant policies. Two had read the federal directive on racial and ethnic classification; one was aware of its current review. Most perceived the four key problems as uncommon. The majority agreed with Public Health Service recommendations on race and ethnicity research, except for analyzing effects of racism. Approximately 20% had discussed issues with co-editors, editorial boards, or reviewers. About 40% saw further discussion as beneficial; four planned to draft guidelines. Editors' potential for helping resolve problems in race/ethnicity research is not being realized. Greater participation would be beneficial to public health research and practice. PMID:9685775

  11. A mutant allele of BARA/LIN-9 rescues the cdk4 {sup -/-} phenotype by releasing the repression on E2F-regulated genes

    SciTech Connect

    Sandoval, Raudel; Xue Jiaping; Tian Xinyong; Barrett, Kelly; Pilkinton, Mark; Ucker, David S.; Raychaudhuri, Pradip; Kineman, Rhonda D.; Luque, Raul M.; Baida, Gleb; Zou, Xianghong; Kiyokawa, Hiroaki; Valli, V.E.; Cook, James L.; Colamonici, Oscar R. . E-mail: ocolamon@uic.edu

    2006-08-01

    It has been proposed that C. elegans LIN-9 functions downstream of CDK4 in a pathway that regulates cell proliferation. Here, we report that mammalian BARA/LIN-9 is a predominantly nuclear protein that inhibits cell proliferation. More importantly, we demonstrate that BARA/LIN-9 also acts downstream of cyclin D/CDK4 in mammalian cells since (i) its antiproliferative effect is partially blocked by coexpression of cyclin D1, and (ii) a mutant form that lacks the first 84 amino acids rescues several phenotypic alterations observed in mice null for cdk4. Interestingly, mutation of BARA/LIN-9 restores the expression of E2F target genes in CDK4 null MEFs, indicating that the wild-type protein plays a role in the expression of genes required for the G1/S transition.

  12. STK Integrated Message Production List Editor (SIMPLE) for CEO Operations

    NASA Technical Reports Server (NTRS)

    Trenchard, Mike; Heydorn, James

    2014-01-01

    Late in fiscal year 2011, the Crew Earth Observations (CEO) team was tasked to upgrade and replace its mission planning and mission operations software systems, which were developed in the Space Shuttle era of the 1980s and 1990s. The impetuses for this change were the planned transition of all workstations to the Windows 7 64-bit operating system and the desire for more efficient and effective use of Satellite Tool Kit (STK) software required for reliable International Space Station (ISS) Earth location tracking. An additional requirement of this new system was the use of the same SQL database of CEO science sites from the SMMS, which was also being developed. STK Integrated Message Production List Editor (SIMPLE) is the essential, all-in-one tool now used by CEO staff to perform daily ISS mission planning to meet its requirement to acquire astronaut photography of specific sites on Earth. The sites are part of a managed, long-term database that has been defined and developed for scientific, educational, and public interest. SIMPLE's end product is a set of basic time and location data computed for an operator-selected set of targets that the ISS crew will be asked to photograph (photography is typically planned 12 to 36 hours out). The CEO operator uses SIMPLE to (a) specify a payload operations planning period; (b) acquire and validate the best available ephemeris data (vectors) for the ISS during the planning period; (c) ingest and display mission-specific site information from the CEO database; (d) identify and display potential current dynamic event targets as map features; (e) compute and display time and location information for each target; (f) screen and select targets based on known crew availability constraints, obliquity constraints, and real-time evaluated constraints to target visibility due to illumination (sun elevation) and atmospheric conditions (weather); and finally (g) incorporate basic, computed time and location information for each selected

  13. Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway

    PubMed Central

    Pérez, Laura M.; Bernal, Aurora; San Martín, Nuria; Lorenzo, Margarita; Fernández-Veledo, Sonia; Gálvez, Beatriz G.

    2013-01-01

    Adipose-derived stem cells (ASCs) are promising candidates for autologous cell-based regeneration therapies by virtue of their multilineage differentiation potential and immunogenicity; however, relatively little is known about their role in adipose tissue physiology and dysfunction. Here we evaluated whether ASCs isolated from nonobese and obese tissue differed in their metabolic characteristics and differentiation potential. During differentiation to mature adipocytes, mouse and human ASCs derived from nonobese tissues both increased their insulin sensitivity and inhibition of lipolysis, whereas obese-derived ASCs were insulin-resistant, showing impaired insulin-stimulated glucose uptake and resistance to the antilipolytic effect of insulin. Furthermore, obese-derived ASCs showed enhanced release of proinflammatory cytokines and impaired production of adiponectin. Interestingly, the delivery of cytosol from control ASCs into obese-derived ASCs using a lipid-based, protein-capture methodology restored insulin sensitivity on glucose and lipid metabolism and reversed the proinflammatory cytokine profile, in part due to the restoration of Lin28 protein levels. In conclusion, glucose and lipid metabolism as well as maturation of ASCs is truncated in an obese environment. The reversal of the altered pathways in obese cells by delivery of normal subcellular fractions offers a potential new tool for cell therapy. PMID:23423565

  14. Minerals detection for hyperspectral images using adapted linear unmixing: LinMin

    NASA Astrophysics Data System (ADS)

    Schmidt, Frédéric; Legendre, Maxime; Le Mouëlic, Stéphane

    2014-07-01

    Minerals detection over large volume of spectra is the challenge addressed by current hyperspectral imaging spectrometer in Planetary Science. Instruments such OMEGA (Mars Express), CRISM (Mars Reconnaissance Orbiter), M3 (Chandrayaan-1), VIRTIS (Rosetta) and many more, have been producing very large datasets since one decade. We propose here a fast supervised detection algorithm called LinMin, in the framework of linear unmixing, with innovative arrangement in order to treat non-linear cases due to radiative transfer in both atmosphere and surface. We use reference laboratory and synthetic spectral library. Additional spectra are used in order to mimic the effect of Martian aerosols, grain size, and observation geometry discrepancies between reference and observed spectra. The proposed algorithm estimates the uncertainty on “mixing coefficient” from the uncertainty of observed spectra. Both numerical and observational tests validate the approach. Fast parallel implementation of the best algorithm (IPLS) on Graphics Processing Units (GPU) allows to significantly reduce the computation cost by a factor of ∼40.

  15. Antimicrobial activity of Blumea balsamifera (Lin.) DC. extracts and essential oil.

    PubMed

    Sakee, Uthai; Maneerat, Sujira; Cushnie, T P Tim; De-Eknamkul, Wanchai

    2011-11-01

    Leaves of Blumea balsamifera (Lin.) DC. are used in traditional Thai and Chinese medicine for the treatment of septic wounds and other infections. In this study, the essential oil, hexane, dichloromethane and methanol extracts of these leaves were evaluated for antibacterial and antifungal activities using the disc diffusion assay and agar microdilution method. The essential oil was the most potent, with a minimum inhibitory concentration (MIC) of 150 µg mL⁻¹ against Bacillus cereus and an MIC of 1.2 mg mL⁻¹ against Staphylococcus aureus and Candida albicans. Activity was also detected from the hexane extract against Enterobacter cloacae and S. aureus. Minimum bactericidal and fungicidal concentrations were typically equal to or two-fold higher than the MICs for both extracts, indicating microbicidal activity. The present data show that B. balsamifera extracts have activity against various infectious and toxin-producing microorganisms. This plant's active constituents could potentially be developed for use in the treatment and/or prevention of microbial disease. PMID:21500092

  16. Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication.

    PubMed

    Sahin, Umut; Ferhi, Omar; Carnec, Xavier; Zamborlini, Alessia; Peres, Laurent; Jollivet, Florence; Vitaliano-Prunier, Adeline; de Thé, Hugues; Lallemand-Breitenbach, Valérie

    2014-01-01

    Small ubiquitin-related modifier (SUMO) protein conjugation onto target proteins regulates multiple cellular functions, including defence against pathogens, stemness and senescence. SUMO1 peptides are limiting in quantity and are thus mainly conjugated to high-affinity targets. Conjugation of SUMO2/3 paralogues is primarily stress inducible and may initiate target degradation. Here we demonstrate that the expression of SUMO1/2/3 is dramatically enhanced by interferons through an miRNA-based mechanism involving the Lin28/let-7 axis, a master regulator of stemness. Normal haematopoietic progenitors indeed display much higher SUMO contents than their differentiated progeny. Critically, SUMOs contribute to the antiviral effects of interferons against HSV1 or HIV. Promyelocytic leukemia (PML) nuclear bodies are interferon-induced domains, which facilitate sumoylation of a subset of targets. Our findings thus identify an integrated interferon-responsive PML/SUMO pathway that impedes viral replication by enhancing SUMO conjugation and possibly also modifying the repertoire of targets. Interferon-enhanced post-translational modifications may be essential for senescence or stem cell self-renewal, and initiate SUMO-dependent proteolysis.

  17. Properties of the fullerene C60-containing PN Lin49 in the SMC; Explanations of strong near-IR excess

    NASA Astrophysics Data System (ADS)

    Otsuka, Masaaki; Kemper, Francisca; Leal-Ferreira, Marcelo L.; Aleman, Isabel; Bernard-Salas, Jeronimo; Cami, Jan; Ochsendorf, Bram; Peeters, Els

    2016-07-01

    We performed a detailed spectroscopic analysis of the fullerene C6o-containing planetary nebula (PN) Lin49 in the Small Magellanic Cloud (SMC). Lin49 is a C-rich and metal- deficient PN (Z∼⃒0.0006) and its nebular abundances are in agreement with the AGB model for the initially 1.25Mʘ stars with the metallicity Z = 0.001 of Fishlock et al. (2014, [1]). By stellar absorption fitting with TLUSTY, we derived stellar abundances, effective temperature, and surface gravity. We constructed the photo-ionization model with CLOUDY in order to investigate physical conditions of Lin49. The model with the 0.005-0.1 μm radius graphite and a constant hydrogen density shell could not fit the ∼⃒1-5 μm SED owing to the strong near-IR excess. We propose that the near-IR excess indicates (1) the presence of extremely small carbon molecules or (2) the presence of high-density structure surrounding the central star.

  18. [Characteristics of atmospheric CO2 concentration and variation of carbon source & sink at Lin'an regional background station].

    PubMed

    Pu, Jing-Jiao; Xu, Hong-Hui; Kang, Li-Li; Ma, Qian-Li

    2011-08-01

    Characteristics of Atmospheric CO2 concentration obtained by Flask measurements were analyzed at Lin'an regional background station from August 2006 to July 2009. According to the simulation results of carbon tracking model, the impact of carbon sources and sinks on CO2 concentration was evaluated in Yangtze River Delta. The results revealed that atmospheric CO2 concentrations at Lin'an regional background station were between 368.3 x 10(-6) and 414.8 x 10(-6). The CO2 concentration varied as seasons change, with maximum in winter and minimum in summer; the annual difference was about 20.5 x 10(-6). The long-term trend of CO2 concentration showed rapid growth year by year; the average growth rate was about 3.2 x 10(-6)/a. CO2 flux of Yangtze River Delta was mainly contributed by fossil fuel burning, terrestrial biosphere exchange and ocean exchange, while the contribution of fire emission was small. CO2 flux from fossil fuel burning played an important role in carbon source; terrestrial biosphere and ocean were important carbon sinks in this area. Seasonal variations of CO2 concentration at Lin'an regional background station were consistent with CO2 fluxes from fossil fuel burning and terrestrial biosphere exchange.

  19. LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans.

    PubMed

    Li, Pengpeng; Collins, Kevin M; Koelle, Michael R; Shen, Kang

    2013-03-19

    The diverse cell types and the precise synaptic connectivity between them are the cardinal features of the nervous system. Little is known about how cell fate diversification is linked to synaptic target choices. Here we investigate how presynaptic neurons select one type of muscles, vm2, as a synaptic target and form synapses on its dendritic spine-like muscle arms. We found that the Notch-Delta pathway was required to distinguish target from non-target muscles. APX-1/Delta acts in surrounding cells including the non-target vm1 to activate LIN-12/Notch in the target vm2. LIN-12 functions cell-autonomously to up-regulate the expression of UNC-40/DCC and MADD-2 in vm2, which in turn function together to promote muscle arm formation and guidance. Ectopic expression of UNC-40/DCC in non-target vm1 muscle is sufficient to induce muscle arm extension from these cells. Therefore, the LIN-12/Notch signaling specifies target selection by selectively up-regulating guidance molecules and forming muscle arms in target cells. DOI:http://dx.doi.org/10.7554/eLife.00378.001.

  20. Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB).

    PubMed

    Chi, Woo; Reinke, Valerie

    2006-08-01

    In Caenorhabditis elegans, EFL-1 (E2F), DPL-1 (DP) and LIN-35 (pRb) act coordinately in somatic tissues to inhibit ectopic cell division, probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act together. Strong loss-of-function mutations in either efl-1 or dpl-1 cause defects in oogenesis that result in sterility, while lin-35 mutants are fertile with reduced broods. Microarray-based expression profiling of dissected gonads from efl-1, dpl-1 and lin-35 mutants reveals that EFL-1 and DPL-1 promote expression of an extensively overlapping set of target genes, consistent with the expectation that these two proteins function as a heterodimer. Regulatory regions upstream of many of these target genes have a canonical E2F-binding site, suggesting that their regulation by EFL-1/DPL-1 is direct. Many EFL-1/DPL-1 responsive genes encode proteins required for oogenesis and early embryogenesis, rather than cell cycle components. By contrast, LIN-35 appears to function primarily as a repressor of gene expression in the germline, and the genes that it acts on are for the most part distinct from those regulated by EFL-1 and/or DPL-1. Thus, in vivo, C. elegans E2F directly promotes oogenesis and embryogenesis through the activation of a tissue-specific transcriptional program that does not require LIN-35.

  1. Human Lin28 Forms a High-Affinity 1:1 Complex with the 106~363 Cluster miRNA miR-363.

    PubMed

    Peters, Daniel T; Fung, Herman K H; Levdikov, Vladimir M; Irmscher, Tobias; Warrander, Fiona C; Greive, Sandra J; Kovalevskiy, Oleg; Isaacs, Harry V; Coles, Mark; Antson, Alfred A

    2016-09-13

    Lin28A is a post-transcriptional regulator of gene expression that interacts with and negatively regulates the biogenesis of let-7 family miRNAs. Recent data suggested that Lin28A also binds the putative tumor suppressor miR-363, a member of the 106~363 cluster of miRNAs. Affinity for this miRNA and the stoichiometry of the protein-RNA complex are unknown. Characterization of human Lin28's interaction with RNA has been complicated by difficulties in producing stable RNA-free protein. We have engineered a maltose binding protein fusion with Lin28, which binds let-7 miRNA with a Kd of 54.1 ± 4.2 nM, in agreement with previous data on a murine homologue. We show that human Lin28A binds miR-363 with a 1:1 stoichiometry and with a similar, if not higher, affinity (Kd = 16.6 ± 1.9 nM). Further analysis suggests that the interaction of the N-terminal cold shock domain of Lin28A with RNA is salt-dependent, supporting a model in which the cold shock domain allows the protein to sample RNA substrates through transient electrostatic interactions. PMID:27559824

  2. Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28.

    PubMed

    Desjardins, Alexandre; Yang, Ao; Bouvette, Jonathan; Omichinski, James G; Legault, Pascale

    2012-02-01

    The pluripotency factor Lin28 is a highly conserved protein comprising a unique combination of RNA-binding motifs, an N-terminal cold-shock domain and a C-terminal region containing two retroviral-type CCHC zinc-binding domains. An important function of Lin28 is to inhibit the biogenesis of the let-7 family of microRNAs through a direct interaction with let-7 precursors. Here, we systematically characterize the determinants of the interaction between Lin28 and pre-let-7 g by investigating the effect of protein and RNA mutations on in vitro binding. We determine that Lin28 binds with high affinity to the extended loop of pre-let-7 g and that its C-terminal domain contributes predominantly to the affinity of this interaction. We uncover remarkable similarities between this C-terminal domain and the NCp7 protein of HIV-1, not only in terms of primary structure but also in their modes of RNA binding. This NCp7-like domain of Lin28 recognizes a G-rich bulge within pre-let-7 g, which is adjacent to one of the Dicer cleavage sites. We hypothesize that the NCp7-like domain initiates RNA binding and partially unfolds the RNA. This partial unfolding would then enable multiple copies of Lin28 to bind the extended loop of pre-let-7 g and protect the RNA from cleavage by the pre-microRNA processing enzyme Dicer. PMID:22013165

  3. Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28

    PubMed Central

    Desjardins, Alexandre; Yang, Ao; Bouvette, Jonathan; Omichinski, James G.; Legault, Pascale

    2012-01-01

    The pluripotency factor Lin28 is a highly conserved protein comprising a unique combination of RNA-binding motifs, an N-terminal cold-shock domain and a C-terminal region containing two retroviral-type CCHC zinc-binding domains. An important function of Lin28 is to inhibit the biogenesis of the let-7 family of microRNAs through a direct interaction with let-7 precursors. Here, we systematically characterize the determinants of the interaction between Lin28 and pre-let-7g by investigating the effect of protein and RNA mutations on in vitro binding. We determine that Lin28 binds with high affinity to the extended loop of pre-let-7g and that its C-terminal domain contributes predominantly to the affinity of this interaction. We uncover remarkable similarities between this C-terminal domain and the NCp7 protein of HIV-1, not only in terms of primary structure but also in their modes of RNA binding. This NCp7-like domain of Lin28 recognizes a G-rich bulge within pre-let-7g, which is adjacent to one of the Dicer cleavage sites. We hypothesize that the NCp7-like domain initiates RNA binding and partially unfolds the RNA. This partial unfolding would then enable multiple copies of Lin28 to bind the extended loop of pre-let-7g and protect the RNA from cleavage by the pre-microRNA processing enzyme Dicer. PMID:22013165

  4. Role of editors and journals in detecting and preventing scientific misconduct: strengths, weaknesses, opportunities, and threats.

    PubMed

    Marusic, Ana; Katavic, Vedran; Marusic, Matko

    2007-09-01

    Scientific journals have a central place in protecting research integrity because published articles are the most visible documentation of research. We used SWOT analysis to audit (S)trengths and (W)eaknesses as internal and (O)pportunities and (T)hreats as external factors affecting journals' responsibility in addressing research integrity issues. Strengths include editorial independence, authority and expertise, power to formulate editorial policies, and responsibility for the integrity of published records. Weaknesses stem from having no mandate for legal action, reluctance to get involved, and lack of training. Opportunities for editors are new technologies for detecting misconduct, policies by editorial organization or national institutions, and greater transparency of published research. Editors face threats from the lack of legal regulation and culture of research integrity in academic communities, lack of support from stakeholders in scientific publishing, and different pressures. Journal editors cannot be the policing force of the scientific community but they should actively ensure the integrity of the scientific record.

  5. Transferable Output ASCII Data (TOAD) editor version 1.0 user's guide

    NASA Technical Reports Server (NTRS)

    Bingel, Bradford D.; Shea, Anne L.; Hofler, Alicia S.

    1991-01-01

    The Transferable Output ASCII Data (TOAD) editor is an interactive software tool for manipulating the contents of TOAD files. The TOAD editor is specifically designed to work with tabular data. Selected subsets of data may be displayed to the user's screen, sorted, exchanged, duplicated, removed, replaced, inserted, or transferred to and from external files. It also offers a number of useful features including on-line help, macros, a command history, an 'undo' option, variables, and a full compliment of mathematical functions and conversion factors. Written in ANSI FORTRAN 77 and completely self-contained, the TOAD editor is very portable and has already been installed on SUN, SGI/IRIS, and CONVEX hosts.

  6. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

    PubMed

    Reddien, Peter W; Andersen, Erik C; Huang, Michael C; Horvitz, H Robert

    2007-04-01

    The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.

  7. lir-2, lir-1 and lin-26 encode a new class of zinc-finger proteins and are organized in two overlapping operons both in Caenorhabditis elegans and in Caenorhabditis briggsae.

    PubMed Central

    Dufourcq, P; Chanal, P; Vicaire, S; Camut, E; Quintin, S; den Boer, B G; Bosher, J M; Labouesse, M

    1999-01-01

    lin-26, which encodes a unique Zn-finger protein, is required for differentiation of nonneuronal ectodermal cells in Caenorhabditis elegans. Here, we show that the two genes located immediately upstream of lin-26 encode LIN-26-like Zn-finger proteins; hence their names are lir-1 and lir-2 (lin-26 related). lir-2, lir-1, and lin-26 generate several isoforms by alternative splicing and/or trans-splicing at different positions. On the basis of their trans-splicing pattern, their intergenic distances, and their expression, we suggest that lir-2, lir-1, and lin-26 form two overlapping transcriptional operons. The first operon, which is expressed in virtually all cells, includes lir-2 and long lir-1 isoforms. The second operon, which is expressed in the nonneuronal ectoderm, includes short lir-1 isoforms, starting at exon 2 and lin-26. This unusual genomic organization has been conserved in C. briggsae, as shown by cloning the C. briggsae lir-2, lir-1, and lin-26 homologs. Particularly striking is the sequence conservation throughout the first lir-1 intron, which is very long in both species. Structural conservation is functionally meaningful as C. briggsae lin-26 is also expressed in the nonneuronal ectoderm and can complement a C. elegans lin-26 null mutation. PMID:10224256

  8. An interactive editor for definition of touch-sensitive zones for a graphic display

    NASA Technical Reports Server (NTRS)

    Monroe, Burt L., III; Jones, Denise R.

    1987-01-01

    In the continuing effort to develop more efficient man-machine communications methods, touch displays have shown potential as straightforward input systems. The development of software necessary to handle such systems, however, can become tedious. In order to reduce the need for redundant programming, a touch editor has been developed which allows a programmer to interactively define touch-sensitive areas for a graphic display. The information produced during the editing process is written to a data file, which can be accessed easily when needed by an application program. This paper outlines the structure, logic, and use of the editor, as well as the hardware with which it is presently compatible.

  9. Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans.

    PubMed

    Kim, Sunhong; Johnson, Wade; Chen, Changchun; Sewell, Aileen K; Byström, Anders S; Han, Min

    2010-08-01

    The elongator (ELP) complex consisting of Elp1-6p has been indicated to play roles in multiple cellular processes. In yeast, the ELP complex has been shown to genetically interact with Uba4p/Urm1p and Kti11-13p for a function in tRNA modification. Through a Caenorhabditis elegans genetic suppressor screen and positional cloning, we discovered that loss-of-function mutations of moc-3 and dph-3, orthologs of the yeast UBA4 and KTI11, respectively, effectively suppress the Multivulva (Muv) phenotype of the lin-1(e1275, R175Opal) mutation. These mutations do not suppress the Muv phenotype caused by other lin-1 alleles or by gain-of-function alleles of ras or raf that act upstream of lin-1. The suppression can also be reverted by RNA interference of lin-1. Furthermore, we showed that dph-3(lf) also suppressed the defect of lin-1(e1275) in promoting the expression of a downstream target (egl-17). These results indicate that suppression by the moc-3 and dph-3 mutations is due to the elevated activity of lin-1(e1275) itself rather than the altered activity of a factor downstream of lin-1. We further showed that loss-of-function mutations of urm-1 and elpc-1-4, the worm counterparts of URM1 and ELP complex components in yeast, also suppressed lin-1(e1275). We also confirmed that moc-3(lf) and dph-3(lf) have defects in tRNA modifications as do the mutants of their yeast orthologs. These results, together with the observation of a likely readthrough product from a lin-1(e1275)::gfp fusion transgene indicate that the aberrant tRNA modification led to failed recognition of a premature stop codon in lin-1(e1275). Our genetic data suggest that the functional interaction of moc-3/urm-1 and dph-3 with the ELP complex is an evolutionarily conserved mechanism involved in tRNA functions that are important for accurate translation. PMID:20479142

  10. Improving the quality of papers submitted to dental journals: Transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Cape Town on Wednesday, 25 June 2014.

    PubMed

    Eaton, Kenneth A; Giannobile, William V; Sourgen, Deborah L; Balaji, S M; Honkala, Eino; Lynch, Christopher D

    2015-08-01

    This satellite symposium was the fourth in a series for editors, publishers, reviewers and all those with an interest in scientific publishing. It was held on Wednesday 25th June 2014 at the IADR International meeting in Cape Town, South Africa. The symposium attracted more than 180 attendees. This symposium placed an emphasis on how the quality of papers submitted to dental journals could be improved. The panel included representation from editors, researchers and publishers from North America, India and the Gulf States. The symposium identified a number of challenges for editors and publishers, including the poor quality of many papers submitted to dental and other scientific journals, plagiarism, attempted duplicate publication and sometimes fraudulent results. Where possible speakers are identified by name. A subsequent symposium was held during the IADR meeting in Boston on March 11th 2015. Involvement open to editors, associate editors, publishers and others with an interest in scientific publishing.

  11. Improving the quality of papers submitted to dental journals: Transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Cape Town on Wednesday, 25 June 2014.

    PubMed

    Eaton, Kenneth A; Giannobile, William V; Sourgen, Deborah L; Balaji, S M; Honkala, Eino; Lynch, Christopher D

    2015-08-01

    This satellite symposium was the fourth in a series for editors, publishers, reviewers and all those with an interest in scientific publishing. It was held on Wednesday 25th June 2014 at the IADR International meeting in Cape Town, South Africa. The symposium attracted more than 180 attendees. This symposium placed an emphasis on how the quality of papers submitted to dental journals could be improved. The panel included representation from editors, researchers and publishers from North America, India and the Gulf States. The symposium identified a number of challenges for editors and publishers, including the poor quality of many papers submitted to dental and other scientific journals, plagiarism, attempted duplicate publication and sometimes fraudulent results. Where possible speakers are identified by name. A subsequent symposium was held during the IADR meeting in Boston on March 11th 2015. Involvement open to editors, associate editors, publishers and others with an interest in scientific publishing. PMID:25748020

  12. EDITORIAL: Editorial from the new Editor-in-Chief for 2014 Editorial from the new Editor-in-Chief for 2014

    NASA Astrophysics Data System (ADS)

    Graham, W. G.

    2014-02-01

    I am honoured to take on the leadership of Plasma Sources Science and Technology (PSST) as the successor to Professor Mark J Kushner, with whom I have had the pleasure to work on the journal for many years. Under Mark's insightful and energetic leadership over the last six years, PSST has cemented its position as the journal of choice within its subject area and is now one of the most successful journals in the field. In this first issue of 2014, I would like to reflect on some of the events and achievements of 2013. At the start of the year the PSST Editorial Board, recognizing the vital importance of atomic, molecular and optical (AMO) data to low-temperature plasma physics, agreed that PSST would accept papers reporting such new data, generated through both experiment and theory. Jonathan Tennyson joined the Editorial Board to represent this area. In March Anne Bourdon joined the Associate Editor team and has since then played a key part in the journal's review process alongside our other Editors. During the autumn, PSST moved to a new editorial management system. In December Deborah O'Connell was awarded the 2013 Hershkowitz Early Career Award and Review and joins the Editorial Board as of 2014. I would also like to thank Miles Turner for his work in leading the drafting of a guide on the details necessary in the reporting of the results of computer simulations; the main conclusions of this report have been incorporated into the journal policy. Overall 2013 has been another successful year for PSST; paper submissions were up by 8% on the previous year and there was the highest ever number of downloads of PSST papers in one year. Another noteworthy feature of 2013 was the continuing improvement in publication times while maintaining our high standards for acceptance and providing expert feedback coupled with encouragement particularly to younger researchers and groups. Largely as a result of the hard work of our referees and Associate Editors, the average time

  13. What Editors and Journalism Educators Expect from Journalism Education; An ANPA News Research Center Survey. News Research Bulletin No. 12.

    ERIC Educational Resources Information Center

    Hulteng, John L.

    The purpose of this survey was to assemble data about the expectations of editors and journalism educators as to journalism education, with the objective of providing a basis for an informed dialogue about ways to advance and support education for journalism. Some of the findings were: editors much less than educators perceived newly-hired…

  14. A Study of the Coorientation of High School Principals, Journalism Teachers, and Local Newspaper Editors in Selected Iowa Communities.

    ERIC Educational Resources Information Center

    Peterson, Jane W.

    A study investigated the extent to which high school journalism teachers, principals, and local newspaper editors in selected Iowa communities have a common understanding of each other and the issues of high school journalism. A questionnaire sent to 187 newspaper editors, high school principals, and journalism teachers was returned by 118…

  15. Advancing the Profession through Journals: The Editor-Author-Profession Partnership [in HRD].

    ERIC Educational Resources Information Center

    1995

    These three papers are from a symposium on professional journals that was facilitated by Wim J. Nijhoff at the 1995 Academy of Human Resource Development (HRD) conference. "Advancing the Profession through Journals: The Editor-Author-Profession Partnership" (Gary N. McLean) describes the purpose and operation of the "Human Resource Development…

  16. Editorial: Conflict of interest policy for Editors of The American Journal of Clinical Nutrition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Integrity in the publication process requires impartiality at all levels of review. The American Journal of Clinical Nutrition (AJCN) adheres to the policy of the International Committee of Medical Journal Editors (ICMJE), Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writin...

  17. The Newspaper Editor As Graphic Strategist. ANPA News Research Report No. 27.

    ERIC Educational Resources Information Center

    Garcia, Mario R.

    This report discusses the graphic strategies available to editors for positioning the day's news. The purposes of the report are: (1) to introduce those in charge of designing the newspaper page to the structural approach to design (the structural approach is defined as incorporating horizontal and vertical structures in the available spaces,…

  18. Professional Wisdom and Writing for Publication: Qualitative Interviews with Editors and Authors in Early Childhood Education

    ERIC Educational Resources Information Center

    Jalongo, Mary Renck

    2013-01-01

    College and university faculty members specializing in early childhood education face some unique challenges in scholarly writing. The purpose of this research was to use open-ended interviews as a way to gather the collective wisdom of a group of key informants about academic writing and publishing in the field. Twenty-two editors and/or authors,…

  19. An International Call for Democratizing the Academic Journal Culture from a Community of Editors

    ERIC Educational Resources Information Center

    Mullen, Carol A.; Pryor, Caroline R.; Browne-Ferrigno, Tricia; Harris, Sandra L.

    2013-01-01

    In our reflective essay from our multiple perspectives as journal editors, peer reviewers, and published authors, we present ideas about editorial support, democracy, and innovation in the publishing process. As four tenured professors who work in universities in the states of Illinois, Virginia, Texas, and Kentucky, we are a community of editors…

  20. Light chain editors of anti-DNA receptors in human B cells.

    PubMed

    Kalinina, Olga; Wang, Yue; Sia, Kevin; Radic, Marko; Cazenave, Pierre-André; Weigert, Martin

    2014-02-10

    Receptor editing is a mechanism of self-tolerance used in newly generated B cells. The expressed heavy (H) or light (L) chain of an autoreactive receptor is replaced by upstream V genes which eliminate or modify autoreactivity. Editing of anti-DNA receptors has been characterized in anti-DNA transgenic mouse models including 3H9, 3H9/56R, and their revertant 3H9GL. Certain L chains, termed editors, rescue anti-DNA B cells by neutralizing or modifying DNA binding of the H chain. This editing mechanism acts on the natural H chain repertoire; endogenous H chains with anti-DNA features are expressed primarily in combination with editor L chains. We ask whether a similar set of L chains exists in the human repertoire, and if so, do they edit H chains with anti-DNA signatures? We compared the protein sequences of mouse editors to all human L chains and found several human L chains similar to mouse editors. These L chains diminish or veto anti-DNA binding when expressed with anti-DNA H chains. The human H chains expressed with these L chains also have relatively high arginine (Arg) content in the H chain complementarity determining region (H3), suggesting that receptor editing plays a role in establishing tolerance to DNA in humans.

  1. Persnickety editor, Founding Father, Mentor and Friend: The Legacy of Fred Mumpton

    NASA Technical Reports Server (NTRS)

    Ming, Douglas W.

    2006-01-01

    This paper is a tribute to Dr Fred Munpton, the founder of the International Committee on Natural Zeolites (ICNZ), by one of his students, who later succeed him as president of the ICNZ. The tribute reflects on Dr. Mumpton's skills as an editor and his zeal for the study of natural zeolites.

  2. Using letters to the editor to try to bring science to the public

    NASA Astrophysics Data System (ADS)

    Aubrecht, Gordon

    2009-10-01

    The local paper here, the Delaware Gazette, publishes many letters from global warming skeptics and people ignorant of energy policy. I explain how I attempt to bring some sense to the situation through reply letters to the editor. Scientists need to express scientific views in public as our duty to fellow citizens.

  3. Learning the Attachment Theory with the CM-ED Concept Map Editor

    ERIC Educational Resources Information Center

    Rueda, U.; Arruarte, A.; Elorriaga, J. A.; Herran, E.

    2009-01-01

    This paper presents a study carried out at the University of the Basque Country UPV/EHU with the aim of evaluating the CM-ED (concept map editor) with social education students. Concept mapping is a widely accepted technique that promotes meaningful learning. Graphically representing concepts of the learning domain and relationships between them…

  4. Guidelines for Reviewers and the Editor at the Nuclear Safety Information Center.

    ERIC Educational Resources Information Center

    Whetsel, H. B.

    The main purpose of this report is to help novice reviewers accelerate their apprenticeship at the Nuclear Safety Information Center, a computerized information service sponsored by the U.S. Atomic Energy Commission. Guidelines for reviewers are presented in Part 1; Part 2 contains guidelines for the novice editor. The goal of the reviewers and…

  5. University-government relationships in the training of technical writers-editors

    NASA Technical Reports Server (NTRS)

    Stohrer, Freda F.; Pinelli, Thomas E.

    1979-01-01

    Traditional and nontraditional methods of training technical writers-editors are reviewed. Combining work experience with classroom instruction in the form of cooperative education provides a method of strengthening the Federal career service in professional occupations. The NASA Langley experience that successfully introduced students to the special demands of technical writing and editing is described.

  6. Improving the Yield of Rural Education Research: An Editor's Swan Song

    ERIC Educational Resources Information Center

    Coladarci, Theodore

    2007-01-01

    In my 15th and final year as JRRE editor, I identify methodological and substantive shortcomings in the rural education research literature and, in turn, suggest strategies for improvement. I structure my observations around the following considerations: describing the rural context of research, making the rural argument, framing the research…

  7. Evolution of Novice Programming Environments: The Structure Editors of Carnegie Mellon University.

    ERIC Educational Resources Information Center

    Miller, Philip; And Others

    1994-01-01

    Describes three projects at Carnegie Mellon University (Pennsylvania) that developed novice programming environments based on structure editors: GNOME, MacGNOME and ACSE (Advanced Computing for Science Education). Tracks the evolution of the programming environments and courses, documenting important lessons and discoveries about novice…

  8. SPADE: A Grammar Based Editor for Planning and Debugging Programs. AI Memo 386.

    ERIC Educational Resources Information Center

    Miller, Mark L.; Goldstein, Ira P.

    The Structured Planning and Debugging Editor (SPADE) is a new kind of interactive programming environment in which computer programs are generated by explicitly articulating planning decisions. The design of SPADE is based upon the development of a grammar of plans from a taxonomy of basic planning techniques. The utility of this approach to…

  9. MUC1-C INDUCES THE LIN28B→LET-7→HMGA2 AXIS TO REGULATE SELF-RENEWAL IN NSCLC

    PubMed Central

    Alam, Maroof; Ahmad, Rehan; Rajabi, Hasan; Kufe, Donald

    2014-01-01

    The LIN28B→let-7 pathway contributes to regulation of the epithelial-mesenchymal transition (EMT) and stem cell self-renewal. The oncogenic MUC1-C transmembrane protein is aberrantly overexpressed in lung and other carcinomas; however, there is no known association between MUC1-C and the LIN28B→let-7 pathway. Here in non-small cell lung cancer (NSCLC), silencing MUC1-C downregulates the RNA binding protein LIN28B and coordinately increases the miRNA let-7. Targeting MUC1-C function with a dominant-negative mutant or a peptide inhibitor provided confirming evidence that MUC1-C induces LIN28B→let-7 signaling. Mechanistically, MUC1-C promotes NF-κB p65 chromatin occupancy of the LIN28B first intron and activates LIN28B transcription, which is associated with suppression of let-7. Consistent with let-7-mediated inhibition of HMGA2 transcripts, targeting of MUC1-C also decreases HMGA2 expression. HMGA2 has been linked to stemness, and functions as a competing endogenous RNA (ceRNA) of let-7-mediated regulation of the TGFβ co-receptor TGFBR3. Accordingly, targeting MUC1-C suppresses HMGA2 mRNA and protein, which is associated with decreases in TGFBR3, reversal of the EMT phenotype and inhibition of self-renewal capacity. These findings support a model in which MUC1-C activates the ⇑LIN28B→⇓let-7→⇑HMGA2 axis in NSCLC and thereby promotes EMT traits and stemness. PMID:25368430

  10. Guidelines, editors, pharma and the biological paradigm shift.

    PubMed

    Singh, Ajai R; Singh, Shakuntala A

    2007-01-01

    relatively recent survey of 2002, it was found that about 60% of 192 authors of clinical practice guidelines reported they had financial connections with the companies whose drugs were under consideration. There is a strong case for making CPGs based not just on effectivity but cost effectivity. The various ramifications of this need to be spelt out. Work of bodies like the Appraisal of Guidelines Research and Evaluation (AGREE) Collaboration and Guidelines Advisory Committee (GAC) are also worth a close look.Even the actions of Foundations that work for disease amelioration have come under scrutiny. The process of setting up 'Best Practices' Guidelines for interactions between the pharmaceutical industry and clinicians has already begun and can have important consequences for patient care. Similarly, Good Publication Practice (GPP) for pharmaceutical companies have also been set up aimed at improving the behaviour of drug companies while reporting drug trialsThe rapidly increasing trend toward influence and control by industry has become a concern for many. It is of such importance that the Association of American Medical Colleges has issued two relatively new documents - one, in 2001, on how to deal with individual conflicts of interest; and the other, in 2002, on how to deal with institutional conflicts of interest in the conduct of clinical research. Academic Medical Centers (AMCs), as also medical education and research institutions at other places, have to adopt means that minimize their conflicts of interest.Both medical associations and research journal editors are getting concerned with individual and institutional conflicts of interest in the conduct of clinical research and documents are now available which address these issues. The 2001 ICMJE revision calls for full disclosure of the sponsor's role in research, as well as assurance that the investigators are independent of the sponsor, are fully accountable for the design and conduct of the trial, have

  11. Guidelines, editors, pharma and the biological paradigm shift.

    PubMed

    Singh, Ajai R; Singh, Shakuntala A

    2007-01-01

    relatively recent survey of 2002, it was found that about 60% of 192 authors of clinical practice guidelines reported they had financial connections with the companies whose drugs were under consideration. There is a strong case for making CPGs based not just on effectivity but cost effectivity. The various ramifications of this need to be spelt out. Work of bodies like the Appraisal of Guidelines Research and Evaluation (AGREE) Collaboration and Guidelines Advisory Committee (GAC) are also worth a close look.Even the actions of Foundations that work for disease amelioration have come under scrutiny. The process of setting up 'Best Practices' Guidelines for interactions between the pharmaceutical industry and clinicians has already begun and can have important consequences for patient care. Similarly, Good Publication Practice (GPP) for pharmaceutical companies have also been set up aimed at improving the behaviour of drug companies while reporting drug trialsThe rapidly increasing trend toward influence and control by industry has become a concern for many. It is of such importance that the Association of American Medical Colleges has issued two relatively new documents - one, in 2001, on how to deal with individual conflicts of interest; and the other, in 2002, on how to deal with institutional conflicts of interest in the conduct of clinical research. Academic Medical Centers (AMCs), as also medical education and research institutions at other places, have to adopt means that minimize their conflicts of interest.Both medical associations and research journal editors are getting concerned with individual and institutional conflicts of interest in the conduct of clinical research and documents are now available which address these issues. The 2001 ICMJE revision calls for full disclosure of the sponsor's role in research, as well as assurance that the investigators are independent of the sponsor, are fully accountable for the design and conduct of the trial, have

  12. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas.

    PubMed

    Yao, Kai; Qiu, Suo; Tian, Lin; Snider, William D; Flannery, John G; Schaffer, David V; Chen, Bo

    2016-09-27

    In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to replenish lost retinal neurons. In mammals, however, MGs lack regenerative capability as they do not spontaneously re-enter the cell cycle unless the retina is injured. Here, we show that gene transfer of β-catenin in adult mouse retinas activates Wnt signaling and MG proliferation without retinal injury. Upstream of Wnt, deletion of GSK3β stabilizes β-catenin and activates MG proliferation. Downstream of Wnt, β-catenin binds to the Lin28 promoter and activates transcription. Deletion of Lin28 abolishes β-catenin-mediated effects on MG proliferation, and Lin28 gene transfer stimulates MG proliferation. We further demonstrate that let-7 miRNAs are critically involved in Wnt/Lin28-regulated MG proliferation. Intriguingly, a subset of cell-cycle-reactivated MGs express markers for amacrine cells. Together, these results reveal a key role of Wnt-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of MGs in the adult mammalian retina. PMID:27681429

  13. A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23.

    PubMed Central

    Mehta, Nehal; Loria, Paula M; Hobert, Oliver

    2004-01-01

    Axon pathfinding and target recognition are highly dynamic and tightly regulated cellular processes. One of the mechanisms involved in regulating protein activity levels during axonal and synaptic development is protein ubiquitination. We describe here the isolation of several Caenorhabditis elegans mutants, termed eno (ectopic/erratic neurite outgrowth) mutants, that display defects in axon outgrowth of specific neuron classes. One retrieved mutant is characterized by abnormal termination of axon outgrowth in a subset of several distinct neuron classes, including ventral nerve cord motor neurons, head motor neurons, and mechanosensory neurons. This mutant is allelic to lin-23, which codes for an F-box-containing component of an SCF E3 ubiquitin ligase complex that was previously shown to negatively regulate postembryonic cell divisions. We demonstrate that LIN-23 is a broadly expressed cytoplasmically localized protein that is required autonomously in neurons to affect axon outgrowth. Our newly isolated allele of lin-23, a point mutation in the C-terminal tail of the protein, displays axonal outgrowth defects similar to those observed in null alleles of this gene, but does not display defects in cell cycle regulation. We have thus defined separable activities of LIN-23 in two distinct processes, cell cycle control and axon patterning. We propose that LIN-23 targets distinct substrates for ubiquitination within each process. PMID:15082545

  14. Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

    SciTech Connect

    Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K.

    2013-05-01

    Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities.

  15. Relevance of the Lin's and Host hydropedological models to predict grape yield and wine quality

    NASA Astrophysics Data System (ADS)

    Costantini, E. A. C.; Pellegrini, S.; Bucelli, P.; Storchi, P.; Vignozzi, N.; Barbetti, R.; Campagnolo, S.

    2009-09-01

    The adoption of precision agriculture in viticulture could be greatly enhanced by the diffusion of straightforward and easy to be applied hydropedological models, able to predict the spatial variability of available soil water. The Lin's and Host hydropedological models were applied to standard soil series descriptions and hillslope position, to predict the distribution of hydrological functional units in two vineyard and their relevance for grape yield and wine quality. A three-years trial was carried out in Chianti (Central Italy) on Sangiovese. The soils of the vineyards differentiated in structure, porosity and related hydropedological characteristics, as well as in salinity. Soil spatial variability was deeply affected by earth movement carried out before vine plantation. Six plots were selected in the different hydrological functional units of the two vineyards, that is, at summit, backslope and footslope morphological positions, to monitor soil hydrology, grape production and wine quality. Plot selection was based upon a cluster analysis of local slope, topographic wetness index (TWI), and cumulative moisture up to the root limiting layer, appreciated by means of a detailed combined geophysical survey. Water content, redox processes and temperature were monitored, as well as yield, phenological phases, and chemical analysis of grapes. The isotopic ratio δ13C was measured in the wine ethanol upon harvesting to evaluate the degree of stress suffered by vines. The grapes in each plot were collected for wine making in small barrels. The wines obtained were analysed and submitted to a blind organoleptic testing. The results demonstrated that the combined application of the two hydropedological models can be used for the prevision of the moisture status of soils cultivated with grape during summertime in Mediterranean climate. As correctly foreseen by the models, the amount of mean daily transpirable soil water (TSW) during the growing season differed

  16. [Co-editors and editors with Jewish origins of the first German journals for anaesthesia. Their fate under National Socialism and an attempt at a biographical appreciation].

    PubMed

    Goerig, M; Goetz, A E

    2010-09-01

    The decision to publish the journals Der Schmerz and Narkose und Anaesthesie in 1928 was an important step towards the professionalization of anaesthesiology in Germany. The appearance of both journals, which for economic reasons merged into Schmerz - Narkose - Anaesthesie 1 year later, was initiated and vehemently supported by Jewish physicians. As editors and co-editors they were deeply involved with the editorial tasks of the journals for years from the early beginnings. When the National Socialistic Party took over the government in Germany many of the Jewish colleagues were forced to quit their editorial tasks, were eliminated and replaced by "Arians", they were persecuted and often arrested, forced to emigrate or decided to commit suicide due to inhumane personal circumstances. It is our intention to recall the biography and the terrible fate of the nearly unknown Jewish members of the editorial board of the first German anaesthesia journals. Moreover the biographic sketches promote a continuous discussion about the victims of an inhumane and barbarous ideology. PMID:20842476

  17. LIN-41 inactivation leads to delayed centrosome elimination and abnormal chromosome behavior during female meiosis in Caenorhabditis elegans.

    PubMed

    Matsuura, Rieko; Ashikawa, Tomoko; Nozaki, Yuka; Kitagawa, Daiju

    2016-03-01

    During oogenesis, two successive meiotic cell divisions occur without functional centrosomes because of the inactivation and subsequent elimination of maternal centrosomes during the diplotene stage of meiosis I. Despite being a conserved phenomenon in most metazoans, the means by which this centrosome behavior is controlled during female meiosis remain elusive. Here, we conducted a targeted RNAi screening in the Caenorhabditis elegans gonad to identify novel regulators of centrosome behavior during oogenesis. We screened 513 genes known to be essential for embryo production and directly visualized GFP-γ-tubulin to monitor centrosome behavior at all stages of oogenesis. In the screening, we found that RNAi-mediated inactivation of 33 genes delayed the elimination of GFP-γ-tubulin at centrosomes during oogenesis, whereas inactivation of nine genes accelerated the process. Depletion of the TRIM-NHL protein LIN-41 led to a significant delay in centrosome elimination and to the separation and reactivation of centrosomes during oogenesis. Upon LIN-41 depletion, meiotic chromosomes were abnormally condensed and pulled toward one of the two spindle poles around late pachytene even though the spindle microtubules emanated from both centrosomes. Overall, our work provides new insights into the regulation of centrosome behavior to ensure critical meiotic events and the generation of intact oocytes.

  18. LIN-41 inactivation leads to delayed centrosome elimination and abnormal chromosome behavior during female meiosis in Caenorhabditis elegans

    PubMed Central

    Matsuura, Rieko; Ashikawa, Tomoko; Nozaki, Yuka; Kitagawa, Daiju

    2016-01-01

    During oogenesis, two successive meiotic cell divisions occur without functional centrosomes because of the inactivation and subsequent elimination of maternal centrosomes during the diplotene stage of meiosis I. Despite being a conserved phenomenon in most metazoans, the means by which this centrosome behavior is controlled during female meiosis remain elusive. Here, we conducted a targeted RNAi screening in the Caenorhabditis elegans gonad to identify novel regulators of centrosome behavior during oogenesis. We screened 513 genes known to be essential for embryo production and directly visualized GFP–γ-tubulin to monitor centrosome behavior at all stages of oogenesis. In the screening, we found that RNAi-mediated inactivation of 33 genes delayed the elimination of GFP–γ-tubulin at centrosomes during oogenesis, whereas inactivation of nine genes accelerated the process. Depletion of the TRIM-NHL protein LIN-41 led to a significant delay in centrosome elimination and to the separation and reactivation of centrosomes during oogenesis. Upon LIN-41 depletion, meiotic chromosomes were abnormally condensed and pulled toward one of the two spindle poles around late pachytene even though the spindle microtubules emanated from both centrosomes. Overall, our work provides new insights into the regulation of centrosome behavior to ensure critical meiotic events and the generation of intact oocytes. PMID:26764090

  19. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.

    PubMed

    Begley, Ulrike; Sosa, Maria Soledad; Avivar-Valderas, Alvaro; Patil, Ashish; Endres, Lauren; Estrada, Yeriel; Chan, Clement T Y; Su, Dan; Dedon, Peter C; Aguirre-Ghiso, Julio A; Begley, Thomas

    2013-03-01

    Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression. Here, we show that a tRNA methyltransferase 9-like (hTRM9L/KIAA1456) mRNA is down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas. In the aggressive SW620 and HCT116 colon carcinoma cell lines, hTRM9L is silenced and its re-expression and methyltransferase activity dramatically suppressed tumour growth in vivo. This growth inhibition was linked to decreased proliferation, senescence-like G0/G1-arrest and up-regulation of the RB interacting protein LIN9. Additionally, SW620 cells re-expressing hTRM9L did not respond to hypoxia via HIF1-α-dependent induction of GLUT1. Importantly, hTRM9L-negative tumours were highly sensitive to aminoglycoside antibiotics and this was associated with altered tRNA modification levels compared to antibiotic resistant hTRM9L-expressing SW620 cells. Our study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-α-dependent mechanisms. It also suggests that aminoglycoside antibiotics may be useful to treat hTRM9L-deficient tumours. PMID:23381944

  20. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway

    PubMed Central

    Chang, Hao-Ming; Triboulet, Robinson; Thornton, James E.; Gregory, Richard I.

    2013-01-01

    The pluripotency factor Lin28 blocks the expression of let-7 microRNAs (miRNAs) in undifferentiated cells during development and functions as an oncogene in a subset of cancers1. Lin28 binds to let-7 precursor RNAs and recruits 3′ terminal uridylyl transferases (TUTases) to selectively inhibit let-7 biogenesis2–4. Uridylated pre-let-7 is refractory to processing by Dicer and is rapidly degraded by an unknown ribonuclease5. Here we identify Dis3l2 as the 3′-5′ exonuclease responsible for the decay of uridylated pre-let-7. Biochemical reconstitution assays reveal that 3′ oligouridylation stimulates Dis3l2 activity in vitro, and knockdown of Dis3l2 in mouse embryonic stem cells leads to the stabilization of pre-let-7. Our study establishes 3′ oligouridylation as an RNA decay signal for Dis3l2 and identifies the first physiological RNA substrate of this novel exonuclease that is mutated in the Perlman syndrome of fetal overgrowth and predisposition to Wilms’ tumor6. PMID:23594738

  1. Programming the Navier-Stokes computer: An abstract machine model and a visual editor

    NASA Technical Reports Server (NTRS)

    Middleton, David; Crockett, Tom; Tomboulian, Sherry

    1988-01-01

    The Navier-Stokes computer is a parallel computer designed to solve Computational Fluid Dynamics problems. Each processor contains several floating point units which can be configured under program control to implement a vector pipeline with several inputs and outputs. Since the development of an effective compiler for this computer appears to be very difficult, machine level programming seems necessary and support tools for this process have been studied. These support tools are organized into a graphical program editor. A programming process is described by which appropriate computations may be efficiently implemented on the Navier-Stokes computer. The graphical editor would support this programming process, verifying various programmer choices for correctness and deducing values such as pipeline delays and network configurations. Step by step details are provided and demonstrated with two example programs.

  2. Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors.

    PubMed

    Gasparyan, Armen Yuri; Ayvazyan, Lilit; Blackmore, Heather; Kitas, George D

    2011-11-01

    Review articles comprehensively covering a specific topic are crucial for successful research and academic projects. Most editors consider review articles for special and regular issues of journals. Writing a review requires deep knowledge and understanding of a field. The aim of this review is to analyze the main steps in writing a narrative biomedical review and to consider points that may increase the chances of success. We performed a comprehensive search through MEDLINE, EMBASE, Scopus, and Web of Science using the following keywords: review of the literature, narrative review, title, abstract, authorship, ethics, peer review, research methods, medical writing, scientific writing, and writing standards. Opinions expressed in the review are also based on personal experience as authors, peer reviewers, and editors.

  3. How is research publishing going to progress in the next 20 years?: transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Seattle on Wednesday, 20 March 2013.

    PubMed

    Eaton, Kenneth A; Rex Holland, G; Giannobile, William V; Hancocks, Stephen; Robinson, Peter G; Lynch, Christopher D

    2014-03-01

    On March 20th 2013, a one-hour session for Editors, Associate Editors, Publishers and others with an interest in scientific publishing was held at the IADR International Session in Seattle. Organised by Kenneth Eaton and Christopher Lynch (Chair and Secretary, respectively, of the British Dental Editors Forum), the meeting sought to bring together leading international experts in dental publishing, as well as authors, reviewers and students engaged in research. The meeting was an overwhelming success, with more than 100 attendees. A panel involving four leading dental editors led a discussion on anticipated developments in publishing dental research with much involvement and contribution from audience members. This was the third such meeting held at the IADR for Editors, Associate Editors, Publishers and others with an interest in scientific publishing. A follow-up session will take place in Cape Town on 25 June 2014 as part of the annual IADR meeting. The transcript of the Seattle meeting is reproduced in this article. Where possible speakers are identified by name. At the first time of mention their role/position is also stated, thereafter only their name appears. We are grateful to Stephen Hancocks Ltd. for their generous sponsorship of this event. For those who were not able to attend the authors hope this article gives a flavour of the discussions and will encourage colleagues to attend future events. Involvement is open to Editors, Associate Editors, Publishers and others with an interest in scientific publishing. It is a very open group and all those with an interest will be welcome to join in.

  4. How is research publishing going to progress in the next 20 years? Transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Seattle on Wednesday, 20 March 2013.

    PubMed

    Eaton, K A; Holland, G R; Giannobile, W V; Hancocks, S; Robinson, P G; Lynch, C D

    2014-05-01

    On March 20th 2013, a one-hour session for Editors, Associate Editors, Publishers and others with an interest in scientific publishing was held at the IADR International Session in Seattle. Organised by Kenneth Eaton and Chris Lynch (Chair and Secretary, respectively, of the British Dental Editors Forum), the meeting sought to bring together leading international experts in dental publishing, as well as authors, reviewers and students engaged in research. The meeting was an overwhelming success, with more than 100 attendees. A panel involving four leading dental editors led a discussion on anticipated developments in publishing dental research with much involvement and contribution from audience members. This was the third such meeting held at the IADR for Editors, Associate Editors, Publishers and others with an interest in scientific publishing. A follow up session will take place in Cape Town on 25 June 2014 as part of the annual IADR meeting. The transcript of the meeting is reproduced in this article. Where possible speakers are identified by name. At the first time of mention their role/ position is also stated, thereafter only their name appears. We are grateful to Stephen Hancocks Ltd for their generous sponsorship of this event. For those who were not able to attend the authors hope this article gives a flavour of the discussions and will encourage colleagues to attend future events. Involvement is open to Editors, Associate Editors, Publishers and others with an interest in scientific publishing. It is a very open group and all those with an interest will be welcome to join in.

  5. Conflicts of interest in biomedical publications: considerations for authors, peer reviewers, and editors.

    PubMed

    Gasparyan, Armen Yuri; Ayvazyan, Lilit; Akazhanov, Nurbek A; Kitas, George D

    2013-12-01

    This article overviews evidence on common instances of conflict of interest (COI) in research publications from general and specialized fields of biomedicine. Financial COIs are viewed as the most powerful source of bias, which may even distort citation outcomes of sponsored publications. The urge to boost journal citation indicators by stakeholders of science communication is viewed as a new secondary interest, which may compromize the interaction between authors, peer reviewers and editors. Comprehensive policies on disclosure of financial and non-financial COIs in scholarly journals are presented as proxies of their indexing in evidence-based databases, and examples of successful medical journals are discussed in detail. Reports on clinical trials, systematic reviews, meta-analyses and clinical practice guidelines may be unduly influenced by author-pharmaceutical industry relations, but these publications do not always contain explicit disclosures to allow the readers to judge the reliability of the published conclusions and practice-changing recommendations. The article emphasizes the importance of adhering to the guidance on COI from learned associations such as the International Committee of Medical Journal Editors (ICMJE). It also considers joint efforts of authors, peer reviewers and editors as a foundation for appropriately defining and disclosing potential COIs.

  6. Improving rural newspaper coverage of nutrition stories: an educational assessment of editors' attitudes and learning needs.

    PubMed

    Nothwehr, Faryle; Chrisman, Matthew; Andsager, Julie L

    2014-11-01

    Local newspapers are an important source of information for rural residents but often lack accurate or helpful nutrition-related information. To improve the quantity and quality of nutrition stories in rural, local newspapers, it is important to understand the perspective of editors. An online survey of 51 rural Midwest editors was conducted to assess attitudes toward writing nutrition stories, sources of information, perceived challenges, and interest in learning more about writing such stories. Of respondents, 49% were female, and 63% had at least a 4-year college degree. Through a mix of closed- and open-ended questions, the majority indicated positive attitudes toward nutrition stories, were confident in their abilities to write them, and expressed interest in learning more. Challenges cited include lack of print space, small staff, lack of specific requests from readers for nutrition stories, and the need to avoid offending local agricultural businesses. Results should be useful in planning an educational intervention for editors. Meanwhile, public health practitioners should provide concise press releases to their local newspapers about their activities. Also, greater expressions of appreciation from public health professionals and other readers may lead to higher prioritization of nutrition-related stories, and ultimately to an environment more supportive of healthy eating.

  7. Reply to B. Meunier's Letter to the Editor Re: Brewer G. J.; Nutrients 2015, 7, 10053-10064.

    PubMed

    Brewer, George J

    2016-01-01

    In a letter to the editor, Meunier [1] apparently attempts to discredit the copper-2 hypothesis for causation of the Alzheimer's disease (AD) epidemic in developed countries proposed by myself in a review in this journal [2].[...]. PMID:27556487

  8. [Heavy metal pollution characteristics and ecological risk analysis for soil in Phyllostachys praecox stands of Lin'an].

    PubMed

    Fang, Xiao-bo; Shi, Han; Liao, Xin-feng; Lou, Zhong; Zhou, Lyu-yan; Yu, Hai-xia; Yao, Lin; Sun, Li-ping

    2015-06-01

    An investigation was carried out in an attempt to reveal the characteristics of heavy metals contamination in the soils of Phyllostachys praecox forest in Lin' an. Based on the concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in 160 topsoil samples, the pollution status and ecological risks of heavy metals in the soils were assessed by single factor pollution index, Nemerow integrated pollution index and Hankanson potential ecological risk index. The spatial variability of heavy metal concentrations in the soils closely related to the distribution of traffic, industrial and livestock pollution sources. The average concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in the soils were 0.16, 7.41, 34.36, 87.98, 103.98, 0.26, 59.12, 29.56, 11.44 and 350.26 mg · kg(-1), respectively. Pb, Cd, Zn and Cu concentrations were as 2.89, 1.70, 1.12 and 1.12 times as the background values of soil in Zhejiang Province, respectively. But their concentrations were all lower than the threshold values of the National Environmental Quality Standard for Soil (GB 15618-1995). The average single factor pollution index revealed that the level of heavy metal pollution in the soils was in order of Pb>Cd>Cu= Zn>Hg>As>Ni>Co>Cr>Mn. Pb pollution was of moderate level while Cd, Cu and Zn pollutions were slight. There was no soil pollution caused by the other heavy metals. However, the Nemerow integrated pollution index showed that all the 160 soil samples were contaminated by heavy metals to a certain extent. Among total 160 soil samples, slight pollution level, moderate pollution level and heavy pollution level accounted for 55.6%, 29.4% and 15.0%, respectively. The average single factor potential ecological risk index (Er(i)) implied that the potential ecological risk related to Cd reached moderate level, while the others were of slight level. Furthermore, Cd and Hg showed higher potential ecological risk indices which reached up to 256.82 and 187.33 respectively

  9. dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.

    PubMed

    Ceol, C J; Horvitz, H R

    2001-03-01

    The synthetic multivulva (synMuv) genes define two functionally redundant pathways that antagonize RTK/Ras signaling during Caenorhabditis elegans vulval induction. The synMuv gene lin-35 encodes a protein similar to the mammalian tumor suppressor pRB and has been proposed to act as a transcriptional repressor. Studies using mammalian cells have shown that pRB can prevent cell cycle progression by inhibiting DP/E2F-mediated transcriptional activation. We identified C. elegans genes that encode proteins similar to DP or E2F. Loss-of-function mutations in two of these genes, dpl-1 DP and efl-1 E2F, caused the same vulval abnormalities as do lin-35 Rb loss-of-function mutations. We propose that rather than being inhibited by lin-35 Rb, dpl-1 DP and efl-1 E2F act with lin-35 Rb in transcriptional repression to antagonize RTK/Ras signaling during vulval development.

  10. Influences of LIN-12/Notch and POP-1/TCF on the Robustness of Ventral Uterine Cell Fate Specification in Caenorhabditis elegans Gonadogenesis.

    PubMed

    Sallee, Maria D; Aydin, Taner; Greenwald, Iva

    2015-10-19

    The prospective ventral uterus of the hermaphrodite gonad primordium consists of two pairs of sister cells, with each pair consisting of a proximal "α" cell and a distal "β" cell. All four cells initially are competent to become the anchor cell (AC), a unique cell type that acts as the organizer of subsequent uterine and vulval development. However, the β cells soon lose this competence and always become ventral uterine precursor cells (VUs), whereas the α cells maintain their AC competence longer, until lin-12/Notch-mediated interactions between them specify one as the AC and the other as a VU. Here, we investigate this asymmetry in developmental potential and VU fate specification between the α and β sister cells. We find evidence that lin-12 activity contributes to the robustness of βVU fate at elevated temperature, that the Caenorhabditis elegans Notch paralog glp-1 is not functionally redundant with lin-12 in specifying βVU fate, and that the activity of POP-1, the sole C. elegans TCF ortholog, influences βVU fate. We propose a model for how Wnt and LIN-12/Notch signaling together lead to robust specification of the βVU fate.

  11. Editor's note

    NASA Astrophysics Data System (ADS)

    2016-06-01

    In this issue, Scott F. Jones and colleagues at the University of Louisiana and USGS provide insight into the potential future changes in the structure of the tidal saline wetlands along the Northern Gulf of Mexico in their Invited Feature Article "Tidal Saline Wetland Regeneration of Sentinel Vegetation Types in the Northern Gulf of Mexico: An Overview". They analysed the ability, and the limits to this ability, of the dominant macrophytes to continuously recolonize and establish after disturbance due to natural and anthropogenic alterations of the hydrology. This analysis leads them to identify important knowledge gaps in the scientific literature on the topics most relevant to land managers.

  12. Editors' Note.

    PubMed

    Cohn, Ellen R; Cason, Jana

    2015-01-01

    The Fall 2015 issue of the International Journal of Telerehabilitation (IJT) presents original articles in the areas of Research; Privacy and Security; and Technology Review. As of May 2015, the International Journal of Telerehabilitation (IJT) is live on PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/journals/2411/. Articles from all past issues are indexed, as will be the current and future issues. PMID:27563381

  13. Editor's note

    NASA Astrophysics Data System (ADS)

    2005-11-01

    Nordita, the Nordic Institute for Theoretical Physics, was founded in 1957 by Niels Bohr and Torsten Gustafsson at Blegdamsvej in Copenhagen, joint to Bohr's legendary Institute. Today, memories of Bohr and his famous visitors -- Albert Einstein, Werner Heisenberg, Lev Landau and many others -- strongly contribute to Nordita's genius loci and inspire next generations of her visitors. Nordita awards ``Nordic Project'' grants to individual Nordic physicists to help conduct a world-class research in Nordic countries (Denmark, Finland, Island, Norway, and Sweden). Research reported here was generously supported by the Nordic Project "Quasi Periodic Oscillations in Black Hole and Neutron Star sources" awarded in 2005 to Marek Abramowicz. The Project supported the ``Nordita Workdays on QPO" (March 25 -- April 1, 2005) organized by Marek Abramowicz, Axel Brandenburg and Juri Poutanen with help of Hanne Bergen, Helle http://www.nordita.dk/positions/norproject.html

  14. Editors' Note.

    PubMed

    Cohn, Ellen R; Cason, Jana

    2016-01-01

    The Spring 2016 issue of the International Journal of Telerehabilitation (IJT) presents original and innovative work in three diverse sections: usability, intervention, and pedagogy, followed by a book review on teleaudiology. The contributors to this issue are notably multi-disciplinary and include an audiologist, computer scientists, engineers, an epidemiologist, occupational therapists, a rehabilitation counselor, a physician (physical medicine and rehabilitation), and speechlanguage pathologists. The common thread linking the Journal's authors and their manuscripts, is excellence in telerehabilitation related innovation. PMID:27563385

  15. Editor's Note

    NASA Astrophysics Data System (ADS)

    2016-10-01

    In the article "Indian summer monsoon rainfall: Dancing with the tunes of the sun", published in New Astronomy 35 (2015) 8, it was omitted to state that at the time this article was submitted the author Dr. Willie Soon received funding from the Southern Company Services under agreement for SAO Proposal PS0182-9-11. We have no indication that this funding has influenced the results presented in the article.

  16. Becoming Editors.

    ERIC Educational Resources Information Center

    MacDonald, Susan

    1993-01-01

    Shows how writing instructors can enhance the peer editing skills of their students and thereby improve the students' own writing and self-editing skills. Outlines a collaborative project used in a ninth-grade writing class that fostered the editing skills of students. (HB)

  17. Editors' note

    NASA Astrophysics Data System (ADS)

    2014-12-01

    The widespread eutrophication of coastal waters has been the subject to much scientific and management effort, yet we have too few examples where there is a substantive scientific record, and sustained tracking of management actions. In this issue Greening and colleagues review the time courses of ambient conditions, describe what was done to remediate severely eutrophic water quality, and demonstrate the recovery trajectory of a number of variables useful to track ecosystem responses. In addition, a compelling aspect of the paper is that it also describes the social side of the recovery, i.e., what was needed to bring the community and political action to perceive and act upon the issues, and develop a plan to address the problems. The improvement in water quality and environmental conditions currently taking place in Tampa Bay is an excellent example of what can be achieved with the combination of basic understanding of the scientific issues, application of reasonable technological advances, and the marshaling of popular support for action.

  18. Editor's note

    NASA Astrophysics Data System (ADS)

    2016-05-01

    In this issue Fabricius, Logan, Weeks, Lewis, and Brodie report a sophisticated synthesis of remotely sensed data that reveals important features of turbidity affecting the Great Barrier Reef region. This study details sources, geographic distributions, and transport, as well as highlights some processes leading to changing turbidity regimes. It is an excellent example of incisive processing and analysis of large, existing data sets, aiming at novel discovery of important aspects of coastal conditions. The results of course beg for efforts at obtaining and examining further information, on associated nutrient deliveries, particularly of nitrogen, detailing biological effects on food webs and corals, and more on the changing baselines that appear imminent. The results of this study therefore are an impressive basis for further work on important aspects of the largest coral region in the world, and could be an example to emulate elsewhere.

  19. Editors' Note.

    PubMed

    Cohn, Ellen R; Cason, Jana

    2015-01-01

    The Fall 2015 issue of the International Journal of Telerehabilitation (IJT) presents original articles in the areas of Research; Privacy and Security; and Technology Review. As of May 2015, the International Journal of Telerehabilitation (IJT) is live on PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/journals/2411/. Articles from all past issues are indexed, as will be the current and future issues.

  20. Editor's note

    NASA Astrophysics Data System (ADS)

    2016-02-01

    In the Invited Feature Article in this issue of Estuarine, Coastal and Shelf Science, Ruben Kosyan and Violeta Velikova describe the disastrous anthropogenic impact on the Black Sea coast of Bulgaria, Georgia, Romania, Russian Federation, Turkey, and Ukraine over the last 100 years and its inverse correlation with economic development as exemplified by improving water quality during a downturn in the economy. This degradation is now accelerating from the renovation and construction of ports and terminals, the development of resorts, hazardous industrial development, oil and gas exploration, and unsustainable agricultural and fishing practices. There appears to be no enforcement of protected areas. In the absence of scientific research on these issues, coastal zone management appears to be based on 'learning after seeing disastrous effects'. Without recognition of the need for Integrated Coastal Zone Management, the Black Sea coast and the coastal waters will deteriorate, as was observed between the 1970s and the 1990s.

  1. Editor's note

    NASA Astrophysics Data System (ADS)

    Courtillot, Vincent

    2015-01-01

    We wish to draw the attention of the readers of Comptes rendus Geoscience to two thematic issues of our companion journals Comptes rendus Physique (volume 16, issue No. 1, 2015, pp. 1-138) and Comptes rendus Mecanique (volume 343, issue No. 2, 2015, pp. 75-178), respectively devoted to "Granular Physics" and to "Mechanics of granular and polycrystalline solids". In particular, the issue of snow avalanches, which is of interest to the community of geoscientists, is widely discussed in these two dossiers.

  2. SMILE'': A Self Magnetically Insulated Transmission LinE adder for the 8-stage RADLAC II accelerator

    SciTech Connect

    Mazarakis, M.G.; Poukey, J.W.; Shope, S.L.; Frost, C.A.; Turman, B.N.; Ramirez, J.J.; Prestwich, K.R. ); Pankuch, P.J. . Special Projects)

    1991-01-01

    The RADLAC II Self Magnetically Insulated Transmission LinE SMILE'' is a coaxial wave guide structure that is composed of two regions: (a) a 9.5-m voltage adder and (b) a 3-m long extension section. The adder section provides for the addition of the input voltages from the individual water-dielectric pulse forming line feeds. The extension section isolates the adder from the magnetically immersed foilless diode electron source load and efficiently transports the pulsed power out from the deionized water tank of the device. The SMILE modification of the RADLAC II accelerator enabled us to produce high quality beams of up to 14 MV, 100 kA. The design and the experimental evaluation of SMILE will be presented and compared with numerical simulation predictions. 12 refs., 9 figs., 1 tab.

  3. Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans.

    PubMed Central

    Henderson, S T; Gao, D; Christensen, S; Kimble, J

    1997-01-01

    The LAG-2 membrane protein is a putative signaling ligand for the LIN-12 and GLP-1 receptors of Caenorhabditis elegans. LAG-2, like its Drosophila homologues Delta and Serrate, acts in a conserved signal transduction pathway to regulate cell fates during development. In this article, we investigate the functional domains of LAG-2. For the most part, mutants were constructed in vitro and assayed for activity in transgenic animals. We find a functional role for all major regions except one. Within the extracellular domain, the N-terminal region, which bears no known motif, and the DSL domain are both required. By contrast, the region bearing epidermal growth factor-like repeats can be deleted with no apparent reduction in rescuing activity. The intracellular region is not required for activity but instead plays a role in down-regulating LAG-2 function. Finally, membrane association is critical for mutant rescue. Images PMID:9307971

  4. Iodine Anions beyond -1: Formation of LinI (n = 2-5) and Its Interaction with Quasiatoms.

    PubMed

    Botana, Jorge; Brgoch, Jakoah; Hou, Chunju; Miao, Maosheng

    2016-09-19

    Novel phases of LinI (n = 2, 3, 4, 5) compounds are predicted to form under high pressure using first-principles density functional theory and an unbiased crystal structure search algorithm. All of the phases identified are thermodynamically stable with respect to decomposition into elemental Li and the binary LiI at a relatively low pressure (≈20 GPa). Increasing the pressure to 100 GPa yields the formation of a high pressure electride where electrons occupy interstitial quasiatom (ISQ) orbitals. Under these extreme pressures, the calculated charge on iodine suggests the oxidation state goes beyond the conventional and expected -1 charge for the halogens. This strange oxidative behavior stems from an electron transfer going from the ISQ to I(-) and Li(+) ions as high pressure collapses the void space. The resulting interplay between chemical bonding and the quantum chemical nature of enclosed interstitial space allows this first report of a halogen anion beyond a -1 oxidation state. PMID:27602431

  5. The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family

    PubMed Central

    Busch, Bianca; Bley, Nadine; Müller, Simon; Glaß, Markus; Misiak, Danny; Lederer, Marcell; Vetter, Martina; Strauß, Hans-Georg; Thomssen, Christoph; Hüttelmaier, Stefan

    2016-01-01

    The tumor-suppressive let-7 microRNA family targets various oncogene-encoding mRNAs. We identify the let-7 targets HMGA2, LIN28B and IGF2BP1 to form a let-7 antagonizing self-promoting oncogenic triangle. Surprisingly, 3′-end processing of IGF2BP1 mRNAs is unaltered in aggressive cancers and tumor-derived cells although IGF2BP1 synthesis was proposed to escape let-7 attack by APA-dependent (alternative polyadenylation) 3′ UTR shortening. However, the expression of the triangle factors is inversely correlated with let-7 levels and promoted by LIN28B impairing let-7 biogenesis. Moreover, IGF2BP1 enhances the expression of all triangle factors by recruiting the respective mRNAs in mRNPs lacking AGO proteins and let-7 miRNAs. This indicates that the downregulation of let-7, largely facilitated by LIN28B upregulation, and the protection of let-7 target mRNAs by IGF2BP1-directed shielding in mRNPs synergize in enhancing the expression of triangle factors. The oncogenic potential of this triangle was confirmed in ovarian cancer (OC)-derived ES-2 cells transduced with let-7 targeting decoys. In these, the depletion of HMGA2 only diminishes tumor cell growth under permissive conditions. The depletion of LIN28B and more prominently IGF2BP1 severely impairs tumor cell viability, self-renewal and 2D as well as 3D migration. In conclusion, this suggests the targeting of the HMGA2-LIN28B-IGF2BP1 triangle as a promising strategy in cancer treatment. PMID:26917013

  6. The TRIM-NHL Protein LIN-41 and the OMA RNA-Binding Proteins Antagonistically Control the Prophase-to-Metaphase Transition and Growth of Caenorhabditis elegans Oocytes

    PubMed Central

    Spike, Caroline A.; Coetzee, Donna; Eichten, Carly; Wang, Xin; Hansen, Dave; Greenstein, David

    2014-01-01

    In many animals, oocytes enter meiosis early in their development but arrest in meiotic prophase I. Oocyte growth, which occurs during this arrest period, enables the acquisition of meiotic competence and the capacity to produce healthy progeny. Meiotic resumption, or meiotic maturation, involves the transition to metaphase I (M phase) and is regulated by intercellular signaling and cyclin-dependent kinase activation. Premature meiotic maturation would be predicted to diminish fertility as the timing of this event, which normally occurs after oocyte growth is complete, is crucial. In the accompanying article in this issue, we identify the highly conserved TRIM-NHL protein LIN-41 as a translational repressor that copurifies with OMA-1 and OMA-2, RNA-binding proteins redundantly required for normal oocyte growth and meiotic maturation. In this article, we show that LIN-41 enables the production of high-quality oocytes and plays an essential role in controlling and coordinating oocyte growth and meiotic maturation. lin-41 null mutants display a striking defect that is specific to oogenesis: pachytene-stage cells cellularize prematurely and fail to progress to diplotene. Instead, these cells activate CDK-1, enter M phase, assemble spindles, and attempt to segregate chromosomes. Translational derepression of the CDK-1 activator CDC-25.3 appears to contribute to premature M-phase entry in lin-41 mutant oocytes. Genetic and phenotypic analyses indicate that LIN-41 and OMA-1/2 exhibit an antagonistic relationship, and we suggest that translational regulation by these proteins could be important for controlling and coordinating oocyte growth and meiotic maturation. PMID:25261698

  7. Stereochemistry of enzymatic transformations of (+)β- and (-)β-HBCD with LinA2--a HCH-degrading bacterial enzyme of Sphingobium indicum B90A.

    PubMed

    Heeb, Norbert V; Wyss, Simon A; Geueke, Birgit; Fleischmann, Thomas; Kohler, Hans-Peter E; Bernd Schweizer, W; Moor, Heidi; Lienemann, Peter

    2015-03-01

    LinA2, a bacterial enzyme expressed in various Sphingomonadaceae, catalyzes the elimination of HCl from hexachlorocyclohexanes (HCHs) and, as discussed here, the release of HBr from certain hexabromocyclododecanes (HBCDs). Both classes of compounds are persistent organic pollutants now regulated under the Stockholm Convention. LinA2 selectively catalyzes the transformation of β-HBCDs; other stereoisomers like α-, γ-, and δ-HBCDs are not converted. The transformation of (-)β-HBCD is considerably faster than that of its enantiomer. Here, we present the XRD crystal structure of 1E,5S,6S,9R,10S-pentabromocyclododecene (PBCDE) and demonstrate that its enantiomer with the 1E,5R,6R,9S,10R-configuration is the only metabolite formed during LinA2-catalyzed dehydrobromination of (-)β-HBCD. Formation of this product can be rationalized by HBr elimination at C5 and C6. A reasonable enzyme-substrate complex with the catalytic dyad His-73 and Asp-25 approaching the hydrogen at C6 and a cationic pocket of Lys-20, Try-42 and Arg-129 binding the leaving bromine at C5 was found from in silico docking experiments. A second PBCDE of yet unknown configuration was obtained from (+)β-HBCD. We predicted its stereochemistry to be 1E,5S,6S,9S,10R-PBCDE from docking experiments. The enzyme-substrate complex obtained from LinA2 and an activated conformation of (+)β-HBCD allows the HBr elimination at C9 and C10 leading to the predicted product. Both modeled enzyme-substrate complexes are in line with 1,2-diaxial HBr eliminations. In conclusion, LinA2, a bacterial enzyme of the HCH-degrading strain Sphingobium indicum B90A was able to stereoselectively convert β-HBCDs. Configurations of both PBCDE metabolites were predicted by molecular docking experiments and confirmed in one case by XRD data.

  8. The TRIM-NHL protein LIN-41 and the OMA RNA-binding proteins antagonistically control the prophase-to-metaphase transition and growth of Caenorhabditis elegans oocytes.

    PubMed

    Spike, Caroline A; Coetzee, Donna; Eichten, Carly; Wang, Xin; Hansen, Dave; Greenstein, David

    2014-12-01

    In many animals, oocytes enter meiosis early in their development but arrest in meiotic prophase I. Oocyte growth, which occurs during this arrest period, enables the acquisition of meiotic competence and the capacity to produce healthy progeny. Meiotic resumption, or meiotic maturation, involves the transition to metaphase I (M phase) and is regulated by intercellular signaling and cyclin-dependent kinase activation. Premature meiotic maturation would be predicted to diminish fertility as the timing of this event, which normally occurs after oocyte growth is complete, is crucial. In the accompanying article in this issue, we identify the highly conserved TRIM-NHL protein LIN-41 as a translational repressor that copurifies with OMA-1 and OMA-2, RNA-binding proteins redundantly required for normal oocyte growth and meiotic maturation. In this article, we show that LIN-41 enables the production of high-quality oocytes and plays an essential role in controlling and coordinating oocyte growth and meiotic maturation. lin-41 null mutants display a striking defect that is specific to oogenesis: pachytene-stage cells cellularize prematurely and fail to progress to diplotene. Instead, these cells activate CDK-1, enter M phase, assemble spindles, and attempt to segregate chromosomes. Translational derepression of the CDK-1 activator CDC-25.3 appears to contribute to premature M-phase entry in lin-41 mutant oocytes. Genetic and phenotypic analyses indicate that LIN-41 and OMA-1/2 exhibit an antagonistic relationship, and we suggest that translational regulation by these proteins could be important for controlling and coordinating oocyte growth and meiotic maturation.

  9. The TRIM-NHL protein LIN-41 and the OMA RNA-binding proteins antagonistically control the prophase-to-metaphase transition and growth of Caenorhabditis elegans oocytes.

    PubMed

    Spike, Caroline A; Coetzee, Donna; Eichten, Carly; Wang, Xin; Hansen, Dave; Greenstein, David

    2014-12-01

    In many animals, oocytes enter meiosis early in their development but arrest in meiotic prophase I. Oocyte growth, which occurs during this arrest period, enables the acquisition of meiotic competence and the capacity to produce healthy progeny. Meiotic resumption, or meiotic maturation, involves the transition to metaphase I (M phase) and is regulated by intercellular signaling and cyclin-dependent kinase activation. Premature meiotic maturation would be predicted to diminish fertility as the timing of this event, which normally occurs after oocyte growth is complete, is crucial. In the accompanying article in this issue, we identify the highly conserved TRIM-NHL protein LIN-41 as a translational repressor that copurifies with OMA-1 and OMA-2, RNA-binding proteins redundantly required for normal oocyte growth and meiotic maturation. In this article, we show that LIN-41 enables the production of high-quality oocytes and plays an essential role in controlling and coordinating oocyte growth and meiotic maturation. lin-41 null mutants display a striking defect that is specific to oogenesis: pachytene-stage cells cellularize prematurely and fail to progress to diplotene. Instead, these cells activate CDK-1, enter M phase, assemble spindles, and attempt to segregate chromosomes. Translational derepression of the CDK-1 activator CDC-25.3 appears to contribute to premature M-phase entry in lin-41 mutant oocytes. Genetic and phenotypic analyses indicate that LIN-41 and OMA-1/2 exhibit an antagonistic relationship, and we suggest that translational regulation by these proteins could be important for controlling and coordinating oocyte growth and meiotic maturation. PMID:25261698

  10. Creating OGC Web Processing Service workflows using a web-based editor

    NASA Astrophysics Data System (ADS)

    de Jesus, J.; Walker, P.; Grant, M.

    2012-04-01

    The OGC WPS (Web Processing Service) specifies how geospatial algorithms may be accessed in an SOA (Service Oriented Architecture). Service providers can encode both simple and sophisticated algorithms as WPS processes and publish them as web services. These services are not only useful individually but may be built into complex processing chains (workflows) that can solve complex data analysis and/or scientific problems. The NETMAR project has extended the Web Processing Service (WPS) framework to provide transparent integration between it and the commonly used WSDL (Web Service Description Language) that describes the web services and its default SOAP (Simple Object Access Protocol) binding. The extensions allow WPS services to be orchestrated using commonly used tools (in this case Taverna Workbench, but BPEL based systems would also be an option). We have also developed a WebGUI service editor, based on HTML5 and the WireIt! Javascript API, that allows users to create these workflows using only a web browser. The editor is coded entirely in Javascript and performs all XSLT transformations needed to produce a Taverna compatible (T2FLOW) workflow description which can be exported and run on a local Taverna Workbench or uploaded to a web-based orchestration server and run there. Here we present the NETMAR WebGUI service chain editor and discuss the problems associated with the development of a WebGUI for scientific workflow editing; content transformation into the Taverna orchestration language (T2FLOW/SCUFL); final orchestration in the Taverna engine and how to deal with the large volumes of data being transferred between different WPS services (possibly running on different servers) during workflow orchestration. We will also demonstrate using the WebGUI for creating a simple workflow making use of published web processing services, showing how simple services may be chained together to produce outputs that would previously have required a GIS (Geographic

  11. News from the editors of Fluids and Barriers of the CNS

    PubMed Central

    2014-01-01

    This editorial announces a new affiliation between Fluids and Barriers of the CNS (FBCNS) and the International Brain Barriers Society (IBBS) with mutual benefits to the journal and to society members. This is a natural progression from the appointment of two new Co-Editors in Chief: Professor Lester Drewes and Professor Richard Keep in 2013. FBCNS provides a unique and specialist platform for the publication of research in the expanding fields of brain barriers and brain fluid systems in both health and disease. PMID:24940481

  12. Quality and peer review of research: an adjudicating role for editors.

    PubMed

    Newton, Douglas P

    2010-05-01

    Peer review gives research a stamp of approval, but the reviews themselves can be flawed. This is potentially serious for the writer, the journal, and journal user. This study describes shortcomings of the peer review process and condenses them into an explanatory framework involving situational, personal, social, and ethical factors. Some proposals to improve matters are impractical and may make them worse. Some data is offered which illustrates the problem and suggests a potential solution. Informed editors who avoid mechanical approaches engage cautiously and critically with reviews and guard against bias, even in themselves, could make a significant difference.

  13. Letters to the editor of the local paper: A scientific responsibility

    NASA Astrophysics Data System (ADS)

    Aubrecht, Gordon

    2011-04-01

    Our local papers often contain, from the point of view of the scientist, strange letters to the editor. As part of our duty to fellow citizens, we need to take the opportunity the bad science in the letters proffers to try to explain the scientific view to readers. In many cases, the letter writers minds are already made up; however, other readers whose heads may nod in agreement to the original letter may become more informed and change their ideas in response. I will describe some of my experiences in trying to meet this responsibility.

  14. Advanced software development workstation. Engineering scripting language graphical editor: DRAFT design document

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Engineering Scripting Language (ESL) is a language designed to allow nonprogramming users to write Higher Order Language (HOL) programs by drawing directed graphs to represent the program and having the system generate the corresponding program in HOL. The ESL system supports user generation of HOL programs through the manipulation of directed graphs. The components of this graphs (nodes, ports, and connectors) are objects each of which has its own properties and property values. The purpose of the ESL graphical editor is to allow the user to create or edit graph objects which represent programs.

  15. Characteristics of highly successful orthopedic surgeons: a survey of orthopedic chairs and editors

    PubMed Central

    Klein, Guy; Hussain, Nasir; Sprague, Sheila; Mehlman, Charles T.; Dogbey, Godwin; Bhandari, Mohit

    2013-01-01

    Background Highly successful orthopedic surgeons are a small group of individuals who exert a large influence on the orthopedic field. However, the characteristics of these leaders have not been well-described or studied. Methods Orthopedic surgeons who are departmental chairs, journal editors, editorial board members of the Journal of Bone and Joint Surgery (British edition), or current or past presidents of major orthopedic associations were invited to complete a survey designed to provide insight into their motivations, academic backgrounds and accomplishments, emotional and physical health, and job satisfaction. Results In all, 152 surgeons completed the questionnaire. We identified several characteristics of highly successful surgeons. Many have contributed prolific numbers of publications and book chapters and obtained considerable funding for research. They were often motivated by a “desire for personal development (interesting challenge, new opportunities),” whereas “relocating to a new institution, financial gain, or lack of alternative candidates” played little to no role in their decisions to take positions of leadership. Most respondents were happy with their specialty choice despite long hours and high levels of stress. Despite challenges to their time, successful orthopedic surgeons made a strong effort to maintain their health; compared with other physicians, they exercise more, are more likely to have a primary care physician and feel better physically. Conclusion Departmental chairs, journal editors and presidents of orthopedic associations cope with considerable demands of clinical, administrative, educational and research duties while maintaining a high level of health, happiness and job satisfaction. PMID:23706848

  16. Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.

    PubMed

    1997-03-19

    A small group of editors of general medical journals met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the US National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually; gradually it has broadened its concerns. The Committee has produced 5 editions of the Uniform Requirements for Manuscripts Submitted to Biomedical Journals. Over the years, issues have arisen that go beyond manuscript preparation. Some of these issues are now covered in the Uniform Requirements; others are addressed in separate statements. Each statement has been published in a scientific journal. The fifth edition (1997) is an effort to reorganize and reword the fourth edition to increase clarity and address concerns about rights, privacy, descriptions of methods, and other matters. The total content of the Uniform Requirements may be reproduced for educational, not-for-profit purposes without regard for copyright; ICMJE encourages distribution of the material. Journals that agree to use the Uniform Requirements (over 500 do so) are asked to cite the 1997 document in their instructions to authors.

  17. Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold

    SciTech Connect

    Kozbial, Piotr; Xu, Qingping; Chiu, Hsiu-Ju; McMullan, Daniel; Krishna, S. Sri; Miller, Mitchell D.; Abdubek, Polat; Acosta, Claire; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Clayton, Thomas; Deller, Marc; Duan, Lian; Elias, Ylva; Elsliger, Marc-André; Feuerhelm, Julie; Grzechnik, Slawomir K.; Hale, Joanna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kumar, Abhinav; Marciano, David; Morse, Andrew T.; Murphy, Kevin D.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Reyes, Ron; Rife, Christopher L.; Spraggon, Glen; Trout, Christina V.; ban den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Wolf, Guenter; Zubieta, Chloe; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2009-08-28

    To extend the structural coverage of proteins with unknown functions, we targeted a novel protein family (Pfam accession number PF08807, DUF1798) for which we proposed and determined the structures of two representative members. The MW1337R gene of Staphylococcus aureus subsp. aureus Rosenbach (Wood 46) encodes a protein with a molecular weight of 13.8 kDa (residues 1-116) and a calculated isoelectric point of 5.15. The lin2004 gene of the nonspore-forming bacterium Listeria innocua Clip11262 encodes a protein with a molecular weight of 14.6 kDa (residues 1-121) and a calculated isoelectric point of 5.45. MW1337R and lin2004, as well as their homologs, which, so far, have been found only in Bacillus, Staphylococcus, Listeria, and related genera (Geobacillus, Exiguobacterium, and Oceanobacillus), have unknown functions and are annotated as hypothetical proteins. The genomic contexts of MW1337R and lin2004 are similar and conserved in related species. In prokaryotic genomes, most often, functionally interacting proteins are coded by genes, which are colocated in conserved operons. Proteins from the same operon as MW1337R and lin2004 either have unknown functions (i.e., belong to DUF1273, Pfam accession number PF06908) or are similar to ypsB from Bacillus subtilis. The function of ypsB is unclear, although it has a strong similarity to the N-terminal region of DivIVA, which was characterized as a bifunctional protein with distinct roles during vegetative growth and sporulation. In addition, members of the DUF1273 family display distant sequence similarity with the DprA/Smf protein, which acts downstream of the DNA uptake machinery, possibly in conjunction with RecA. The RecA activities in Bacillus subtilis are modulated by RecU Holliday-junction resolvase. In all analyzed cases, the gene coding for RecU is in the vicinity of MW1337R, lin2004, or their orthologs, but on a different operon located in the complementary DNA strand. Here, we report the crystal structures

  18. Korean association of medical journal editors at the forefront of improving the quality and indexing chances of its member journals.

    PubMed

    Suh, Chang-Ok; Oh, Se Jeong; Hong, Sung-Tae

    2013-05-01

    The article overviews some achievements and problems of Korean medical journals published in the highly competitive journal environment. Activities of Korean Association of Medical Journal Editors (KAMJE) are viewed as instrumental for improving the quality of Korean articles, indexing large number of local journals in prestigious bibliographic databases and launching new abstract and citation tracking databases or platforms (eg KoreaMed, KoreaMed Synapse, the Western Pacific Regional Index Medicus [WPRIM]). KAMJE encourages its member journals to upgrade science editing standards and to legitimately increase citation rates, primarily by publishing more great articles with global influence. Experience gained by KAMJE and problems faced by Korean editors may have global implications.

  19. Wikipedia and Medicine: Quantifying Readership, Editors, and the Significance of Natural Language

    PubMed Central

    West, Andrew G

    2015-01-01

    Background Wikipedia is a collaboratively edited encyclopedia. One of the most popular websites on the Internet, it is known to be a frequently used source of health care information by both professionals and the lay public. Objective This paper quantifies the production and consumption of Wikipedia’s medical content along 4 dimensions. First, we measured the amount of medical content in both articles and bytes and, second, the citations that supported that content. Third, we analyzed the medical readership against that of other health care websites between Wikipedia’s natural language editions and its relationship with disease prevalence. Fourth, we surveyed the quantity/characteristics of Wikipedia’s medical contributors, including year-over-year participation trends and editor demographics. Methods Using a well-defined categorization infrastructure, we identified medically pertinent English-language Wikipedia articles and links to their foreign language equivalents. With these, Wikipedia can be queried to produce metadata and full texts for entire article histories. Wikipedia also makes available hourly reports that aggregate reader traffic at per-article granularity. An online survey was used to determine the background of contributors. Standard mining and visualization techniques (eg, aggregation queries, cumulative distribution functions, and/or correlation metrics) were applied to each of these datasets. Analysis focused on year-end 2013, but historical data permitted some longitudinal analysis. Results Wikipedia’s medical content (at the end of 2013) was made up of more than 155,000 articles and 1 billion bytes of text across more than 255 languages. This content was supported by more than 950,000 references. Content was viewed more than 4.88 billion times in 2013. This makes it one of if not the most viewed medical resource(s) globally. The core editor community numbered less than 300 and declined over the past 5 years. The members of this

  20. Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

    PubMed

    Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

    2016-01-28

    Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function.

  1. Origin of the Galactic Center S-Stars: Gravitational Torques from Lin-Shu-Type Spiral Density Waves

    NASA Astrophysics Data System (ADS)

    Griv, Evgeny

    2010-02-01

    The supermassive ~4 × 106 M sun black hole at the Galactic center is surrounded by a parsec-scale star disk, with several thousands of dynamically relaxed, evolved, late-type CO absorption line stars and a small ~100 population of luminous O and Wolf-Rayet stars which move in approximately circular Keplerian orbits. These bluish in color massive O and Wolf-Rayet stars are very young with an estimated age of 6 ± 2 Myr. Another small group of roughly 20 young (<10 Myr) blue B stars with the orbital periods as short as 15 years ("S-stars") follow eccentric, randomly oriented orbits well inside the disk stars. A model is proposed to explain the S-stars. Accordingly, the stars formed originally in the parsec-scale disk through Jeans' gravitational fragmentation of gas. The newly formed S-stars then migrated inward to the Galactic center via the torques exerted by Lin-Shu-type spiral density waves on the stars at an inner Lindblad resonance. The model explains both the number of observed S-stars orbiting the Galactic black hole within the nuclear (<0.05 pc) star cluster and the key property of the S-star orbits, namely, their high eccentricities.

  2. Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration.

    PubMed

    Bachmann, André; Grawe, Ferdi; Johnson, Kevin; Knust, Elisabeth

    2008-03-01

    The Drosophila Crumbs protein complex is required to maintain epithelial cell polarity in the embryo, to ensure proper morphogenesis of photoreceptor cells and to prevent light-dependent retinal degeneration. In Drosophila, the core components of the complex are the transmembrane protein Crumbs, the membrane-associated guanylate kinase (MAGUK) Stardust and the scaffolding protein DPATJ. The composition of the complex and some of its functions are conserved in mammalian epithelial and photoreceptor cells. Here, we report that Drosophila Lin-7, a scaffolding protein with one Lin-2/Lin-7 (L27) domain and one PSD-95/Dlg/ZO-1 (PDZ) domain, is associated with the Crumbs complex in the subapical region of embryonic and follicle epithelia and at the stalk membrane of adult photoreceptor cells. DLin-7 loss-of-function mutants are viable and fertile. While DLin-7 localization depends on Crumbs, neither Crumbs, Stardust nor DPATJ require DLin-7 for proper accumulation in the subapical region. Unlike other components of the Crumbs complex, DLin-7 is also enriched in the first optic ganglion, the lamina, where it co-localizes with Discs large, another member of the MAGUK family. In contrast to crumbs mutant photoreceptor cells, those mutant for DLin-7 do not display any morphogenetic abnormalities. Similar to crumbs mutant eyes, however, DLin-7 mutant photoreceptors undergo progressive, light-dependent degeneration. These results support the previous conclusions that the function of the Crumbs complex in cell survival is independent from its function in photoreceptor morphogenesis.

  3. A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.

    PubMed Central

    Rocheleau, Christian E; Howard, Robyn M; Goldman, Alissa P; Volk, Mandy L; Girard, Laura J; Sundaram, Meera V

    2002-01-01

    In Caenorhabditis elegans, the Ras/Raf/MEK/ERK signal transduction pathway controls multiple processes including excretory system development, P12 fate specification, and vulval cell fate specification. To identify positive regulators of Ras signaling, we conducted a genetic screen for mutations that enhance the excretory system and egg-laying defects of hypomorphic lin-45 raf mutants. This screen identified unusual alleles of several known Ras pathway genes, including a mutation removing the second SH3 domain of the sem-5/Grb2 adaptor, a temperature-sensitive mutation in the helical hairpin of let-341/Sos, a gain-of-function mutation affecting a potential phosphorylation site of the lin-1 Ets domain transcription factor, a dominant-negative allele of ksr-1, and hypomorphic alleles of sur-6/PP2A-B, sur-2/Mediator, and lin-25. In addition, this screen identified multiple alleles of two newly identified genes, eor-1 and eor-2, that play a relatively weak role in vulval fate specification but positively regulate Ras signaling during excretory system development and P12 fate specification. The spectrum of identified mutations argues strongly for the specificity of the enhancer screen and for a close involvement of eor-1 and eor-2 in Ras signaling. PMID:12019228

  4. Synthesis and structural characterization of novel amidinolithium compounds by the insertion reaction of CO2 into the Li-N bond

    NASA Astrophysics Data System (ADS)

    Qin, Qi; Guo, Zhiqiang; Wei, Xuehong

    2016-06-01

    Insertion of CO2 into the Li-N bond of two amidinolithium compounds [{LiN(2,6-Me2C6H3)C(H)N(2,6- Me2C6H3)}2(THF)3] and [{LiN(4-CH3C6H4)C(H)N(4-CH3C6H4)}2(THF)3] have been studied, and two lithium carbamate compounds [Li{O2C(N(2,6-Me2C6H3)C(H)N(2,6-Me2C6H3))}·THF]4 (1) and [Li{O2C(N(4-CH3C6H4)C(H)N(4-CH3C6H4))}·THF]6 (2) were obtained. The molecular structure of 1 shows a novel cage structure containing four eight-membered (LiOCOLiOCO) rings and two four-membered (LiOLiO) rings with the [Li4(CO2)4]4+ cluster in central. And an unusual and novel structure of 2 was obtained with a "wheel" cage structure including six six-membered (LiOLiOCO) rings surrounding the [Li6(CO2)6]6+ cluster. Both of 1 and 2 were fully characterized by elemental analysis, NMR spectroscopy, and X-ray structural determinations.

  5. EDITORIAL: A few words from the new Editor-in-Chief A few words from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Margaritondo, Giorgio

    2011-04-01

    As I begin my mandate as Editor-in-Chief of Journal of Physics D: Applied Physics, I can look back with great pleasure at many years of service, as a member of the Editorial Board, to this outstanding instrument of scientific dissemination. Having witnessed the exceptional quantitative and qualitative growth of the journal, I must consider this appointment both an honour and a real challenge. The success of the journal is primarily based on three assets: the authors' talent of course, but also the illuminated leadership of my predecessors at the journal helm and the highly competent, dedicated and responsive staff. I would like to praise, in particular, the leadership of my immediate predecessor and good friend, Pallab Battacharya, the pilot of the years of major qualitative growth. Being Pallab's successor makes my new responsibility even more challenging! The IOP personnel is a key asset for the journal: in my rather broad experience in scientific publishing, I have never seen such a combination of professional experience, commitment and willingness to innovate—a traditional strength of JPD. Regrettably, I cannot acknowledge here all the women and men who contributed to the success of the journal; however, I would like to explicitly acknowledge the outstanding work of Sarah Quin over the past decade. In my new duty, I can fortunately count on her successor, Olivia Roche, whose excellent professional and managerial qualities we can already appreciate. How should we view the future of the journal? In my view, with reasonable optimism. Notwithstanding the tough competition, our journal has a solid reputation and increasing visibility. It has consistently belonged to the small elite group of top journals preferred by applied physics authors worldwide. My program as Editor-in-Chief is both simple and very testing: to continue to enhance this elite status. The challenge comes from a variety of factors: first, 'applied physics' is a continuously evolving notion, even

  6. ESCHER: An interactive mesh-generating editor for preparing finite-element input

    NASA Technical Reports Server (NTRS)

    Oakes, W. R., Jr.

    1984-01-01

    ESCHER is an interactive mesh generation and editing program designed to help the user create a finite-element mesh, create additional input for finite-element analysis, including initial conditions, boundary conditions, and slidelines, and generate a NEUTRAL FILE that can be postprocessed for input into several finite-element codes, including ADINA, ADINAT, DYNA, NIKE, TSAAS, and ABUQUS. Two important ESCHER capabilities, interactive geometry creation and mesh archival storge are described in detail. Also described is the interactive command language and the use of interactive graphics. The archival storage and restart file is a modular, entity-based mesh data file. Modules of this file correspond to separate editing modes in the mesh editor, with data definition syntax preserved between the interactive commands and the archival storage file. Because ESCHER was expected to be highly interactive, extensive user documentation was provided in the form of an interactive HELP package.

  7. JOSPT Experiences Tremendous Growth, Change in 14 Years With Editor-in-Chief Simoneau in Charge.

    PubMed

    Nyland, John A

    2015-12-01

    As Editor-in-Chief, Dr Guy G. Simoneau and his editorial board have taken JOSPT from an acceptable US-based journal to a highly influential worldwide force behind contemporary orthopaedic and sports physical therapy research and practice. Today, the bridge Dr Simoneau constructed spans the orthopaedic and sports physical therapy globe for the betterment of clinical practice and research. His work fully supports JOSPT's latest strategic plan to provide value-added knowledge translation, develop a broader authorship and readership, increase global marketing of the JOSPT brand, and expand current relationships to new partners and stakeholders. The bridge places JOSPT on very firm footing, tying its rich history to the promise of an exciting and successful future. PMID:26620640

  8. Clinical trial registration in physiotherapy journals: recommendations from the International Society of Physiotherapy Journal Editors.

    PubMed

    Costa, Leonardo O P; Lin, Chung-Wei Christine; Grossi, Debora Bevilaqua; Mancini, Marisa Cota; Swisher, Anne K; Cook, Chad E; Vaughn, Daniel W; Elkins, Mark R; Sheikh, Umer; Moore, Ann; Jull, Gwendolen A; Craik, Rebecca L; Maher, Christopher G; Guirro, Rinaldo Roberto de Jesus; Marques, Amélia Pasqual; Harms, Michele; Brooks, Dina; Simoneau, Guy G; Strupstad, John Henry

    2012-12-01

    Clinical trial registration involves placing the protocol for a clinical trial on a free, publicly available, and electronically searchable register. Registration is considered to be prospective if the protocol is registered before the trial commences (ie, before the first participant is enrolled). Prospective registration has several potential advantages. It could help avoid trials being duplicated unnecessarily and it could allow people with health problems to identify trials in which they might participate. Perhaps more importantly, however, it tackles 2 big problems in clinical research: selective reporting and publication bias. Prospective clinical trial registration is of great potential value to the clinicians, consumers, and researchers who rely on clinical trial data, and that is why the International Society of Physiotherapy Journal Editors (ISPJE) is recommending that members enact a policy for prospective trial registration.

  9. MrEnt: an editor for publication-quality phylogenetic tree illustrations.

    PubMed

    Zuccon, Alessandro; Zuccon, Dario

    2014-09-01

    We developed MrEnt, a Windows-based, user-friendly software that allows the production of complex, high-resolution, publication-quality phylogenetic trees in few steps, directly from the analysis output. The program recognizes the standard Nexus tree format and the annotated tree files produced by BEAST and MrBayes. MrEnt combines in a single software a large suite of tree manipulation functions (e.g. handling of multiple trees, tree rotation, character mapping, node collapsing, compression of large clades, handling of time scale and error bars for chronograms) with drawing tools typical of standard graphic editors, including handling of graphic elements and images. The tree illustration can be printed or exported in several standard formats suitable for journal publication, PowerPoint presentation or Web publication.

  10. Publishing bioethics and bioethics--reflections on academic publishing by a journal editor.

    PubMed

    Schüklenk, Udo

    2011-02-01

    This article by one of the Editors of Bioethics, published in the 25th anniversary issue of the journal, describes some of the revolutionary changes academic publishing has undergone during the last decades. Many humanities journals went from typically small print-runs, counting by the hundreds, to on-line availability in thousands of university libraries worldwide. Article up-take by our subscribers can be measured efficiently. The implications of this and other changes to academic publishing are discussed. Important ethical challenges need to be addressed in areas such as the enforcement of plagiarism-related policies, the so-called 'impact factor' and its impact on academic integrity, and the question of whether on-line only publishing can currently guarantee the integrity of academic publishing histories.

  11. Grammar, Punctuation, and Capitalization: a Handbook for Technical Writers and Editors

    NASA Technical Reports Server (NTRS)

    Mccaskill, Mary K.

    1990-01-01

    Writing problems are addressed which are often encountered in technical documents and preferences are indicated (Langley's) when authorities do not agree. It is directed toward professional writers, editors, and proofreaders. Those whose profession lies in other areas (for example, research or management), but who have occasion to write or review others' writing will also find this information useful. A functional attitude toward grammar and punctuation is presented. Chapter 1 on grammar presents grammatical problems related to each part of speech. Chapter 2 on sentence structure concerns syntax, that is, effective arrangement of words, with emphasis on methods of revision to improve writing effectiveness. Chapter 3 addresses punctuation marks, presenting their function, situations when they are required or incorrect, and situations when they are appropriate but optional. Chapter 4 presents capitalization, which is mostly a matter of editorial style and preference rather than a matter of generally accepted rules. An index and glossary are included.

  12. Prior Publication and Redundancy in Contemporary Science: Are Authors and Editors at the Crossroads?

    PubMed

    de Vasconcelos, Sonia Maria Ramos; Roig, Miguel

    2015-10-01

    We discuss prior publication and redundancy in contemporary science in the context of changing perceptions of originality in the communication of research results. These perceptions have been changing in the publication realm, particularly in the last 15 years. Presenting a brief overview of the literature, we address some of the conflicts that are likely to arise between authors and editors. We illustrate our approach with conference presentations that are later published as journal articles and focus on a recent retraction of an article that had been previously published as a conference proceedings. Although we do not make definitive pronouncements on the matter-as many concepts are evolving-we do argue that conference papers that contain sufficient details for others to attempt a replication and are indexed in scientific databases such as PubMed, challenge some currently held assumptions of prior publication and originality in the sciences. Our view is that these important issues are in need of further clarification and harmonization within the science publishing community. This need is more evident when we consider current notions of research integrity when it comes to communication to peers. Revisiting long-standing views about what constitutes prior publication and developing a clearer set of guidelines for authors and editors to follow should reduce conflicts in the research environment, which already exerts considerable pressure, especially on newcomers in academia. However, while clearer guidelines are timely, developing them is only part of the challenge. The present times seem to call for deeper changes in the research and publication systems. PMID:25341850

  13. Prior Publication and Redundancy in Contemporary Science: Are Authors and Editors at the Crossroads?

    PubMed

    de Vasconcelos, Sonia Maria Ramos; Roig, Miguel

    2015-10-01

    We discuss prior publication and redundancy in contemporary science in the context of changing perceptions of originality in the communication of research results. These perceptions have been changing in the publication realm, particularly in the last 15 years. Presenting a brief overview of the literature, we address some of the conflicts that are likely to arise between authors and editors. We illustrate our approach with conference presentations that are later published as journal articles and focus on a recent retraction of an article that had been previously published as a conference proceedings. Although we do not make definitive pronouncements on the matter-as many concepts are evolving-we do argue that conference papers that contain sufficient details for others to attempt a replication and are indexed in scientific databases such as PubMed, challenge some currently held assumptions of prior publication and originality in the sciences. Our view is that these important issues are in need of further clarification and harmonization within the science publishing community. This need is more evident when we consider current notions of research integrity when it comes to communication to peers. Revisiting long-standing views about what constitutes prior publication and developing a clearer set of guidelines for authors and editors to follow should reduce conflicts in the research environment, which already exerts considerable pressure, especially on newcomers in academia. However, while clearer guidelines are timely, developing them is only part of the challenge. The present times seem to call for deeper changes in the research and publication systems.

  14. Publication Criteria and Recommended Areas of Improvement within School Psychology Journals as Reported by Editors, Journal Board Members, and Manuscript Authors

    ERIC Educational Resources Information Center

    Albers, Craig A.; Floyd, Randy G.; Fuhrmann, Melanie J.; Martinez, Rebecca S.

    2011-01-01

    Two online surveys were completed by editors, associate editors, editorial board members, and members or fellows of the Division 16 of the American Psychological Association. These surveys targeted (a) the criteria for a manuscript to be published in school psychology journals, and (b) the components of the peer-review process that should be…

  15. A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans.

    PubMed

    Hale, Jared J; Amin, Nirav M; George, Carolyn; Via, Zachary; Shi, Herong; Liu, Jun

    2014-05-15

    The proper formation and function of an organ is dependent on the specification and integration of multiple cell types and tissues. An example of this is the Caenorhabditis elegans hermaphrodite egg-laying system, which requires coordination between the vulva, uterus, neurons, and musculature. While the genetic constituents of the first three components have been well studied, little is known about the molecular mechanisms underlying the specification of the egg-laying musculature. The egg-laying muscles are non-striated in nature and consist of sixteen cells, four each of type I and type II vulval muscles and uterine muscles. These 16 non-striated muscles exhibit distinct morphology, location, synaptic connectivity and function. Using an RNAi screen targeting the putative transcription factors in the C. elegans genome, we identified a number of novel factors important for the diversification of these different types of egg-laying muscles. In particular, we found that RNAi knockdown of lag-1, which encodes the sole C. elegans ortholog of the transcription factor CSL (CBF1, Suppressor of Hairless, LAG-1), an effector of the LIN-12/Notch pathway, led to the production of extra type I vulval muscles. Similar phenotypes were also observed in animals with down-regulation of the Notch receptor LIN-12 and its DSL (Delta, Serrate, LAG-2) ligand LAG-2. The extra type I vulval muscles in animals with reduced LIN-12/Notch signaling resulted from a cell fate transformation of type II vulval muscles to type I vulval muscles. We showed that LIN-12/Notch was activated in the undifferentiated type II vulval muscle cells by LAG-2/DSL that is likely produced by the anchor cell (AC). Our findings provide additional evidence highlighting the roles of LIN-12/Notch signaling in coordinating the formation of various components of the functional C. elegans egg-laying system. We also identify multiple new factors that play critical roles in the proper specification of the different types

  16. On-Line Student Publications: Do Student Editors at Public Universities Shed Their First Amendment Rights in Cyberspace?

    ERIC Educational Resources Information Center

    Senat, Joey

    The First Amendment rights of students at public universities and colleges are well established by federal and state courts. Where a publication has been created as a forum for student expression, college authorities may not exercise anything but advisory control over editorial decisions of student editors. On-line student newspapers and literary…

  17. [P. I. Shatilov--original domestic clinician, scientist and teacher, one of the first editors of medical journal "Vrachebnoe Delo"].

    PubMed

    Lesovoĭ, V N; Pertseva, Zh N

    2009-01-01

    The article tells about life and activity of original domestic clinician, scientist and teacher, one of the first managing editors of medical journal "Vrachebnoe Delo". P. I. Shatilov was presented as individuality, who united in himself such moral values as humanism, disinterestedness, faithfulness to physician duty, selflessness, understanding of participation in public activity. PMID:20455462

  18. 77 FR 74175 - Solicitation of Review Editors for the Draft Report of the National Climate Assessment and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ... Report of the National Climate Assessment and Development Advisory Committee (NCADAC). AGENCY: Office of... editors of the National Climate Assessment and Development Advisory Committee (NCADAC) National Climate... Research Program at email@usgcrp.gov . More information on the National Climate Assessment can be found...

  19. Embracing the Outsider, and Suffering Change: Charles A. Martin, Former Editor-in Chief, "The Journal of Negro Education"

    ERIC Educational Resources Information Center

    Martin, Charles A.

    2007-01-01

    This article highlights the accomplishments and challenges of former Editor-in-Chief of "The Journal of Negro Education", Charles A. Martin. He documents the changes he made to the JNE as well as the resistance he faced, which made the process more complicated. There is also a discussion of the impact of "No Child Left Behind Act" on factors…

  20. Serials Management in the Electronic Era: Papers in Honor of Peter Gellatly, Founding Editor of "The Serials Librarian."

    ERIC Educational Resources Information Center

    Cole, Jim, Ed.; Williams, James W., Ed.

    This book assesses progress and technical changes in the field of serials management and anticipates future directions and challenges for librarians. The book consists of 18 chapters: (1) "Introduction" (Jim Cole and James W. Williams); (2) "Peter Gellatly--Editor with a Deft Touch" (Ruth C. Carter); (3) "The "Deseret News" Web Edition" (Stewart…

  1. [P. I. Shatilov--original domestic clinician, scientist and teacher, one of the first editors of medical journal "Vrachebnoe Delo"].

    PubMed

    Lesovoĭ, V N; Pertseva, Zh N

    2009-01-01

    The article tells about life and activity of original domestic clinician, scientist and teacher, one of the first managing editors of medical journal "Vrachebnoe Delo". P. I. Shatilov was presented as individuality, who united in himself such moral values as humanism, disinterestedness, faithfulness to physician duty, selflessness, understanding of participation in public activity.

  2. New Editor-in-Chief for Journal of Physics D: Applied Physics New Editor-in-Chief for Journal of Physics D: Applied Physics

    NASA Astrophysics Data System (ADS)

    2011-04-01

    The Institute of Physics is delighted to announce that the new Editor-in-Chief for Journal of Physics D: Applied Physics will be Professor Giorgio Margaritondo of École Polytechnique Fédérale de Lausanne, Switzerland. Giorgio will, with the help of his world-class Editorial Board, maintain standards of scientific rigour whilst ensuring that research published is of the highest quality. 'I would like to praise, in particular, the leadership of my immediate predecessor and good friend, Pallab Battacharya, the pilot of the years of major qualitative growth.' said Professor Margaritondo. 'Being Pallab's successor makes my new responsibility even more challenging!' Professor Margaritondo received the Laurea Summa cum Laude from the University of Rome in 1969. He has been a full professor of Applied Physics at the EPFL since 1990. In 2001, he became Dean of the EPFL Faculty of Basic Sciences. In 2004, he was nominated Provost and he served until 2010, when he became Dean of Continuing Education. He previously worked at the Italian National Research Council, at Bell Laboratories and at the University of Wisconsin-Madison. His research activity concerns the physics of semiconductors and superconductors (electronic states, surfaces and interfaces) and of biological systems; his main experimental techniques are electron spectroscopy and spectromicroscopy, x-ray imaging and scanning near-field microscopy, including experiments with synchrotron light and with free electron lasers. Author of more than 650 scientific publications and 9 books, he was also coordinator in 1995-98 of the scientific division of the Elettra synchrotron in Trieste. In 1997-2003 he was coordinator of the European Commission Round Table on synchrotron radiation. He is the president of the Council of the European Commission Integrated Initiative on Synchrotron and Free Electron Laser Science (IA-SFS and then ELISA), the largest network in the world in this domain. He is Fellow of the American Physical

  3. Gene expression profile and functionality of ESC-derived Lin-ckit+Sca-1+ cells are distinct from Lin-ckit+Sca-1+ cells isolated from fetal liver or bone marrow.

    PubMed

    Fernandez, Irina; Fridley, Krista M; Arasappan, Dhivya; Ambler, Rosalind V; Tucker, Philip W; Roy, Krishnendu

    2012-01-01

    In vitro bioreactor-based cultures are being extensively investigated for large-scale production of differentiated cells from embryonic stem cells (ESCs). However, it is unclear whether in vitro ESC-derived progenitors have similar gene expression profiles and functionalities as their in vivo counterparts. This is crucial in establishing the validity of ESC-derived cells as replacements for adult-isolated cells for clinical therapies. In this study, we compared the gene expression profiles of Lin-ckit+Sca-1+ (LKS) cells generated in vitro from mouse ESCs using either static or bioreactor-based cultures, with that of native LKS cells isolated from mouse fetal liver (FL) or bone marrow (BM). We found that in vitro-generated LKS cells were more similar to FL- than to BM LKS cells in gene expression. Further, when compared to cells derived from bioreactor cultures, static culture-derived LKS cells showed fewer differentially expressed genes relative to both in vivo LKS populations. Overall, the expression of hematopoietic genes was lower in ESC-derived LKS cells compared to cells from BM and FL, while the levels of non-hematopoietic genes were up-regulated. In order to determine if these molecular profiles correlated with functionality, we evaluated ESC-derived LKS cells for in vitro hematopoietic-differentiation and colony formation (CFU assay). Although static culture-generated cells failed to form any colonies, they did differentiate into CD11c+ and B220+ cells indicating some hematopoietic potential. In contrast, bioreactor-derived LKS cells, when differentiated under the same conditions failed to produce any B220+ or CD11c+ cells and did not form colonies, indicating that these cells are not hematopoietic progenitors. We conclude that in vitro culture conditions significantly affect the transcriptome and functionality of ESC-derived LKS cells and although in vitro differentiated LKS cells were lineage negative and expressed both ckit and Sca-1, these cells

  4. Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.

    PubMed

    Garbe, David; Doto, Jeffrey B; Sundaram, Meera V

    2004-06-01

    Retinoblastoma (Rb)/E2F complexes repress expression of many genes important for G(1)-to-S transition, but also appear to regulate gene expression at other stages of the cell cycle. In C. elegans, lin-35/Rb and other synthetic Multivulva (SynMuv) group B genes function redundantly with other sets of genes to regulate G(1)/S progression, vulval and pharyngeal differentiation, and other unknown processes required for viability. Here we show that lin-35/Rb, efl-1/E2F, and other SynMuv B genes negatively regulate a component of the anaphase-promoting complex or cyclosome (APC/C). The APC/C is a multisubunit complex that promotes metaphase-to-anaphase progression and G(1) arrest by targeting different substrates for ubiquitination and proteasome-mediated destruction. The C. elegans APC/C gene mat-3/APC8 has been defined by temperature-sensitive embryonic lethal alleles that strongly affect germline meiosis and mitosis but only weakly affect somatic development. We describe severe nonconditional mat-3 alleles and a hypomorphic viable allele (ku233), all of which affect postembryonic cell divisions including those of the vulval lineage. The ku233 lesion is located outside of the mat-3 coding region and reduces mat-3 mRNA expression. Loss-of-function alleles of lin-35/Rb and other SynMuv B genes suppress mat-3(ku233) defects by restoring mat-3 mRNA to wild-type levels. Therefore, Rb/E2F complexes appear to repress mat-3 expression.

  5. Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.

    PubMed Central

    Garbe, David; Doto, Jeffrey B; Sundaram, Meera V

    2004-01-01

    Retinoblastoma (Rb)/E2F complexes repress expression of many genes important for G(1)-to-S transition, but also appear to regulate gene expression at other stages of the cell cycle. In C. elegans, lin-35/Rb and other synthetic Multivulva (SynMuv) group B genes function redundantly with other sets of genes to regulate G(1)/S progression, vulval and pharyngeal differentiation, and other unknown processes required for viability. Here we show that lin-35/Rb, efl-1/E2F, and other SynMuv B genes negatively regulate a component of the anaphase-promoting complex or cyclosome (APC/C). The APC/C is a multisubunit complex that promotes metaphase-to-anaphase progression and G(1) arrest by targeting different substrates for ubiquitination and proteasome-mediated destruction. The C. elegans APC/C gene mat-3/APC8 has been defined by temperature-sensitive embryonic lethal alleles that strongly affect germline meiosis and mitosis but only weakly affect somatic development. We describe severe nonconditional mat-3 alleles and a hypomorphic viable allele (ku233), all of which affect postembryonic cell divisions including those of the vulval lineage. The ku233 lesion is located outside of the mat-3 coding region and reduces mat-3 mRNA expression. Loss-of-function alleles of lin-35/Rb and other SynMuv B genes suppress mat-3(ku233) defects by restoring mat-3 mRNA to wild-type levels. Therefore, Rb/E2F complexes appear to repress mat-3 expression. PMID:15238519

  6. Getting published well requires fulfilling editors' and reviewers' needs and desires.

    PubMed

    Schoenwolf, Gary C

    2013-12-01

    Publication in international scientific journals provides an unparalleled opportunity for authors to showcase their work. Where authors publish affects how the community values the work. This value directly determines the impact of the work on the field-papers must be read and cited to advance the field, and because the scientific literature is vast, only a subset of the literature is widely read and cited. Moreover, the value placed on the work also affects the authors' scientific reputation and career advancement. Consequently, it is essential that manuscripts receive the recognition they deserve by being published in one of the "best" journals that the scientific findings allow. Several factors determine where a paper is published: how well the topic of the paper fits the scope of the journal, the quality of the study and the manuscript describing it, the advance the paper makes in its field, the importance of the advance, and the extent to which the paper impacts the broader community of science. As scientists, we assume that our papers will be assessed objectively using only well defined scientific standards, but editors and reviewers also view papers subjectively, having biases of what defines a high-quality publication based on Western standards. Therefore, scientists trained in other parts of the world can be significantly disadvantaged in getting their papers published in the best journals. Here, I present concrete suggestions for improving the perception of a paper in the reader's minds, increasing the likelihood that it will get published well.

  7. Macedonian journal of chemistry and chemical engineering: open journal systems--editor's perspective.

    PubMed

    Zdravkovski, Zoran

    2014-01-01

    The development and availability of personal computers and software as well as printing techniques in the last twenty years have made a profound change in the publication of scientific journals. Additionally, the Internet in the last decade has revolutionized the publication process to the point of changing the basic paradigm of printed journals. The Macedonian Journal of Chemistry and Chemical Engineering in its 40-year history has adopted and adapted to all these transformations. In order to keep up with the inevitable changes, as editor-in-chief I felt my responsibility was to introduce an electronic editorial managing of the journal. The choice was between commercial and open source platforms, and because of the limited funding of the journal we chose the latter. We decided on Open Journal Systems, which provided online submission and management of all content, had flexible configuration--requirements, sections, review process, etc., had options for comprehensive indexing, offered various reading tools, had email notification and commenting ability for readers, had an option for thesis abstracts and was installed locally. However, since there is limited support it requires a moderate computer knowledge/skills and effort in order to set up. Overall, it is an excellent editorial platform and a convenient solution for journals with a low budget or journals that do not want to spend their resources on commercial platforms or simply support the idea of open source software.

  8. [Bogdan Suchodolski--initiator and editor-in-chief of the publication History of Polish Science].

    PubMed

    Kuźnicka, Barbara; Kuźnicki, Leszek

    2011-01-01

    Among numerous and distinguished author's and editorial works of Bogdan Suchodolski a particular value presents a publication in eight volumes entitled 'History of Polish Science' (including two biographical and bibliographic volumes), which was published in the years 1970-1992 on Professor's own initiative and edited by himself. This is the first synthesis of the history of science in Poland, from the beginning of the Middle Ages till the present time (to 1952). In the conception of the initiator and editor the work presents the development of scientific thought and achievements of the scholars in relation to national culture and in connexions with the trends in science in the world. 'History of Polish Science' is the work written by several dozen authors, representing different domains of the knowledge. Scientific, organizational and editorial patronate was possible by dint of History of Science and Technology Establishment of Polish Academy of Sciences (presently the Institute for the History of Science of Polish Academy of Sciences), which was managed by Bogdan Suchodolski.

  9. Scheduling and programming of rapid finger sequences: tests and elaborations of the hierarchical editor model.

    PubMed

    Rosenbaum, D A; Hindorff, V; Munro, E M

    1987-05-01

    Is a response sequence executed only after the sequence has been fully programmed, as discrete processing models predict, or does execution begin before programming has been completed, as continuous processing models predict? To address this issue, we tested a discrete processing model of human motor performance, the hierarchical editor model of Rosenbaum, Inhoff, and Gordon (1984). This model was developed to account for data from experiments in which people perform one of two possible finger sequences, depending on the identity of a choice signal. The model assumes a hierarchically organized motor program that is first "edited" to resolve any uncertainties and is then "executed" to produce the desired responses. Three experiments reported here show that, contrary to the model's predictions and some well-known motor programming results (Sternberg, Monsell, Knoll, & Wright, 1978), the reaction time to begin a response sequence actually decreases with the length of the sequence under some choice conditions. We account for these results with a model that allows execution to begin while editing is still in progress. A key assumption in the model is that subjects schedule execution so that means and variances of interresponse times are minimized.

  10. Getting published well requires fulfilling editors' and reviewers' needs and desires.

    PubMed

    Schoenwolf, Gary C

    2013-12-01

    Publication in international scientific journals provides an unparalleled opportunity for authors to showcase their work. Where authors publish affects how the community values the work. This value directly determines the impact of the work on the field-papers must be read and cited to advance the field, and because the scientific literature is vast, only a subset of the literature is widely read and cited. Moreover, the value placed on the work also affects the authors' scientific reputation and career advancement. Consequently, it is essential that manuscripts receive the recognition they deserve by being published in one of the "best" journals that the scientific findings allow. Several factors determine where a paper is published: how well the topic of the paper fits the scope of the journal, the quality of the study and the manuscript describing it, the advance the paper makes in its field, the importance of the advance, and the extent to which the paper impacts the broader community of science. As scientists, we assume that our papers will be assessed objectively using only well defined scientific standards, but editors and reviewers also view papers subjectively, having biases of what defines a high-quality publication based on Western standards. Therefore, scientists trained in other parts of the world can be significantly disadvantaged in getting their papers published in the best journals. Here, I present concrete suggestions for improving the perception of a paper in the reader's minds, increasing the likelihood that it will get published well. PMID:24131034

  11. Representing Nature of Science in a Science Textbook: Exploring author-editor-publisher interactions

    NASA Astrophysics Data System (ADS)

    DiGiuseppe, Maurice

    2014-05-01

    Current reforms in elementary and secondary science education call for students and teachers to develop more informed views of the nature of science (NOS)-a process in which science textbooks play a significant role. This paper reports on a case study of the development of representations of the NOS in a senior high school chemistry textbook by the book's author, editor, and publisher. The study examines the multiple discourses that arose as the developers reflected on their personal and shared understandings of NOS; squared these with mandated curricula, the educational needs of chemistry students and teachers, and the exigencies of large-scale commercial textbook publishing. As a result, the team developed and incorporated, in the textbook, representations of NOS they believed were the most pedagogically suitable. Analysis of the data in this study indicates that a number of factors significantly influenced the development of representations of NOS, including representational accuracy (the degree to which representations of NOS conformed to informed views of the NOS), representational consistency (the degree to which representations of NOS in different parts of the book conveyed the same meaning), representational appropriateness (the age-, grade-, and reading-level appropriateness of the NOS representations), representational alignment (the degree to which NOS representations aligned with mandated curriculum), representational marketability (the degree to which NOS representations would affect sales of the textbook), and 'Workplace Resources' factors including availability of time, relevant expertise, and opportunities for professional development.

  12. Seven decades of history of science: I. Bernard Cohen (1914-2003), second editor of Isis.

    PubMed

    Dauben, Joseph W; Gleason, Mary Louise; Smith, George E

    2009-03-01

    I. Bernard Cohen (1914-2003), the first American to receive a Ph.D. in history of science, was a Harvard undergraduate ('37) and then a Ph.D. student and protégé of George Sarton, founder of Isis and the History of Science Society. He went on to succeed Sarton as editor of Isis (1952-1958) and, later, president of the Society (1961-1962); he was also a president of the International Union of the History and Philosophy of Science. Cohen was an internationally recognized Newton scholar; his interests were encyclopedic, ranging from science and public policy to the history of computers, with several decades as a special consultant for history of computing with IBM. Among his hundreds of publications were such major books as Franklin and Newton (1956), The Birth of a New Physics (1959; rpt., 1985), The Newtonian Revolution (1980), Revolution in Science (1985), Science and the Founding Fathers (1995), Howard Aiken: Portrait of a Computer Pioneer (1999), and his last book, The Triumph of Numbers (2005), not to mention two jointly authored contributions, the variorum edition and new English translation of Newton's Principia, which will surely still be read a century from now.

  13. IntellEditS: intelligent learning-based editor of segmentations.

    PubMed

    Harrison, Adam P; Birkbeck, Neil; Sofka, Michal

    2013-01-01

    Automatic segmentation techniques, despite demonstrating excellent overall accuracy, can often produce inaccuracies in local regions. As a result, correcting segmentations remains an important task that is often laborious, especially when done manually for 3D datasets. This work presents a powerful tool called Intelligent Learning-Based Editor of Segmentations (IntellEditS) that minimizes user effort and further improves segmentation accuracy. The tool partners interactive learning with an energy-minimization approach to editing. Based on interactive user input, a discriminative classifier is trained and applied to the edited 3D region to produce soft voxel labeling. The labels are integrated into a novel energy functional along with the existing segmentation and image data. Unlike the state of the art, IntellEditS is designed to correct segmentation results represented not only as masks but also as meshes. In addition, IntellEditS accepts intuitive boundary-based user interactions. The versatility and performance of IntellEditS are demonstrated on both MRI and CT datasets consisting of varied anatomical structures and resolutions. PMID:24505766

  14. Late Quaternary landscape evolution and genesis of the 2009 catastrophic landslide in the Hsiao-lin area, southwestern Taiwan

    NASA Astrophysics Data System (ADS)

    Hsieh, Meng-Long; Lai, Larry Syu-Heng; Lin, Chris Ding-Jyun; Shyu, J. Bruce H.

    2012-12-01

    With cumulative rainfall of 1700 mm, Typhoon Morakot triggered a catastrophic landslide at Hsiao-lin (9 August, 2009), which dammed the river, buried the village and killed > 400 people. We conducted a geomorphic study to understand the origin of this landslide in the context of the long-term evolution of the hillslope. The landslide originated from a broad, poorly drained slope (21°-23°) and ran down along two first-order channels. The erosion, up to 80 m thick, has created a concave-shape slope and exposed mostly loose debris, which implies that the landslide was mainly the reworking of ancient colluviums. The genesis of the concave-shape slope where the source sediments of the landslide resided reflects the weakness of the mudstone/shale bedrock underlying this slope, in contrast to the sandstone-based transport area. The two channels in the transport area also follow old faults or joints. Given that the source area has been subject to erosion during large landslides, the subsequent deposition here was likely achieved by minor colluvial processes. This deposition continued until the catastrophic failure in 2009, which could be controlled by (1) the amount of sediments deposited, which determined the slope angle, and (2) the headward expansion of the channels from the transport area, which enhanced groundwater convergence and later provided routes for the landslide materials to run downslope. Extensive mass-wasting motions had occurred in the area, as shown by the prevalence of > 20 m thick landslide/debris-flow sequences on the lower part of the hillslope, which are dated 21, 14.9, 13.7 and 12.0 ka by the radiocarbon method. These mass-wasting events had hindered the long-term incision of the trunk river in response to the rapid tectonic uplift. At least the 12.0 ka event, which caused extensive mud-flow deposition, had dammed the river. Overall, this study shows how bedrock lithology and structures controlled the shape of a hillslope and caused extremely

  15. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b.

    PubMed

    Cotterman, Rebecca; Knoepfler, Paul S

    2009-01-01

    myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells. For example, N-myc is associated with a number of tumors including neuroblastoma, but also plays a central role in the function of normal neural stem and precursor cells (NSC). Both c- and N-myc also enhance the production of induced pluripotent stem cells (iPSC) and are linked to neural tumor stem cells. The mechanisms by which myc regulates normal and neoplastic stem-related functions remain largely open questions. Here from a global, unbiased search for N-Myc bound genes using ChIP-chip assays in neuroblastoma, we found lif as a putative N-Myc bound gene with a number of strong N-Myc binding peaks in the promoter region enriched for E-boxes. Amongst putative N-Myc target genes in expression microarray studies in neuroblastoma we also found lif and three additional important embryonic stem cell (ESC)-related factors that are linked to production of iPSC: klf2, klf4, and lin28b. To examine the regulation of these genes by N-Myc, we measured their expression using neuroblastoma cells that contain a Tet-regulatable N-myc transgene (TET21N) as well as NSC with a nestin-cre driven N-myc knockout. N-myc levels closely correlated with the expression of all of these genes in neuroblastoma and all but lif in NSC. Direct ChIP assays also indicate that N-Myc directly binds the lif promoter. N-Myc regulates trimethylation of lysine 4 of histone H3 in the promoter of lif and possibly in the promoters of several other stem-related genes. Together these findings indicate that N-Myc regulates overlapping stem-related gene expression programs in neuroblastoma and NSC, supporting a novel model by which amplification of the N-myc gene may drive formation of neuroblastoma. They also suggest mechanisms by which Myc proteins more generally contribute to maintenance of pluripotency and self-renewal of ESC as well as to i

  16. Korean Association of Medical Journal Editors at the Forefront of Improving the Quality and Indexing Chances of its Member Journals

    PubMed Central

    Suh, Chang-Ok; Oh, Se Jeong

    2013-01-01

    The article overviews some achievements and problems of Korean medical journals published in the highly competitive journal environment. Activities of Korean Association of Medical Journal Editors (KAMJE) are viewed as instrumental for improving the quality of Korean articles, indexing large number of local journals in prestigious bibliographic databases and launching new abstract and citation tracking databases or platforms (eg KoreaMed, KoreaMed Synapse, the Western Pacific Regional Index Medicus [WPRIM]). KAMJE encourages its member journals to upgrade science editing standards and to legitimately increase citation rates, primarily by publishing more great articles with global influence. Experience gained by KAMJE and problems faced by Korean editors may have global implications. PMID:23678253

  17. [Letters to the editor published in Peruvian biomedical journals indexed in SciELO-Peru 2006-2013].

    PubMed

    Montenegro-Idrogo, Juan José; Mejía-Dolores, Jhon William; Chalco-Huamán, Joel L

    2015-01-01

    This bibliometric study describes the characteristics of letters to the editor published between 2006-2013 in biomedical journals indexed in SciELO-Peru.253 letters (10.3% of total publications) were collected. Most letters (139) were in the Peruvian Journal of Experimental Medicine and Public Health, with marked increase throughout those years. 25% of letters submitted included medical student participation. 14% of authors presented with international affiliations and 27% with endogenous affiliation - common in university journals (Anales de la Facultad de Medicina, Revista Médica Herediana).The usual criteria justifying the publication of letters were: opinion of medical fact or public domain (35.6%) and discussion of results, methodological flaws or interpretation (22.9%). In biomedical journals indexed in SciELO Peru the letters to the editor comprise a percentage of publications that has increased in recent years, with low publication of letters of findings or primary data, compared with opinion or criticism.

  18. [Luis Hidalgo y Carpio, Editor of Gaceta Médica de México (1818-1879)].

    PubMed

    Rodríguez-Pérez, Martha Eugenia

    2009-01-01

    Luis Hidalgo y Carpio (1818-1879) was a notable physician who made important contributions to the field of medicine during his time. Nevertheless, reference sources on the aspect from Hidalgo y Carpio that we would like to emphasize (i.e. as an editor of a medical journal) are scarce since precisely when Hidalgo y Carpio was named President of the Medical Society (later the Academia Nacional de Medicina), in 1987, the publication of the Gaceta Médica de México was temporarily interrupted. Hidalgo y Carpio played a key role as an editor at a time when the medical community of Mexico required a means whereby the scientific achievements could be published and discussed among peers and colleagues. Under Hidalgo y Carpio, the Gaceta Médica de México soon reached a wide audience, not only as a periodical publication but also for the prestige of the Academy that represented.

  19. The effects of an editor serving as one of the reviewers during the peer-review process

    PubMed Central

    Giordan, Marco; Csikasz-Nagy, Attila; Collings, Andrew M.; Vaggi, Federico

    2016-01-01

    Background Publishing in scientific journals is one of the most important ways in which scientists disseminate research to their peers and to the wider public. Pre-publication peer review underpins this process, but peer review is subject to various criticisms and is under pressure from growth in the number of scientific publications. Methods Here we examine an element of the editorial process at eLife, in which the Reviewing Editor usually serves as one of the referees, to see what effect this has on decision times, decision type, and the number of citations. We analysed a dataset of 8,905 research submissions to eLife since June 2012, of which 2,750 were sent for peer review, using R and Python to perform the statistical analysis. Results The Reviewing Editor serving as one of the peer reviewers results in faster decision times on average, with the time to final decision ten days faster for accepted submissions (n=1,405) and 5 days faster for papers that were rejected after peer review (n=1,099). There was no effect on whether submissions were accepted or rejected, and a very small (but significant) effect on citation rates for published articles where the Reviewing Editor served as one of the peer reviewers. Conclusions An important aspect of eLife’s peer-review process is shown to be effective, given that decision times are faster when the Reviewing Editor serves as a reviewer. Other journals hoping to improve decision times could consider adopting a similar approach. PMID:27508056

  20. The effects of an editor serving as one of the reviewers during the peer-review process.

    PubMed

    Giordan, Marco; Csikasz-Nagy, Attila; Collings, Andrew M; Vaggi, Federico

    2016-01-01

    Background Publishing in scientific journals is one of the most important ways in which scientists disseminate research to their peers and to the wider public. Pre-publication peer review underpins this process, but peer review is subject to various criticisms and is under pressure from growth in the number of scientific publications. Methods Here we examine an element of the editorial process at eLife, in which the Reviewing Editor usually serves as one of the referees, to see what effect this has on decision times, decision type, and the number of citations. We analysed a dataset of 8,905 research submissions to eLife since June 2012, of which 2,750 were sent for peer review, using R and Python to perform the statistical analysis. Results The Reviewing Editor serving as one of the peer reviewers results in faster decision times on average, with the time to final decision ten days faster for accepted submissions (n=1,405) and 5 days faster for papers that were rejected after peer review (n=1,099). There was no effect on whether submissions were accepted or rejected, and a very small (but significant) effect on citation rates for published articles where the Reviewing Editor served as one of the peer reviewers. Conclusions An important aspect of eLife's peer-review process is shown to be effective, given that decision times are faster when the Reviewing Editor serves as a reviewer. Other journals hoping to improve decision times could consider adopting a similar approach. PMID:27508056

  1. Representing the nature of science in a science textbook: Exploring author-editor-publisher interactions

    NASA Astrophysics Data System (ADS)

    Digiuseppe, Maurizio

    Current reforms in elementary and secondary science education call for students and teachers to develop more informed views of the nature of science---a process in which learning materials like science textbooks play a significant role. This dissertation reports on a case study of the development of representations of the nature of science in one unit of a senior high school chemistry textbook by the book's author, editor, and publisher. The study examines the multiple discourses that arose as the developers reflected on their personal and shared understandings of the nature of science; squared these understandings with mandated curricula, the educational needs of chemistry students and teachers, and the exigencies of large-scale commercial textbook publishing; and developed and incorporated into the textbook representations of the nature of science they believed were the most suitable. Analyses of the data in this study indicate that a number of factors significantly influenced the development of representations of the nature of science, including representational accuracy (the degree to which suggested representations of the nature of science conformed to what the developers believed were contemporary understandings of the nature of science), representational consistency (the degree to which similar representations of the nature of science in different parts of the textbook conveyed the same meaning), representational appropriateness (the age-, grade-, and reading-level suitability of the suggested nature of science representations), representational alignment (the degree to which suggested representations of the nature of science addressed the requirements of mandated curricula), representational marketability (the degree to which textbook developers believed suggested representations of the nature of science would affect sales of the textbook in the marketplace), and a number of "Workplace Resources" factors such as the availability of time, relevant expertise

  2. DINAMO: a coupled sequence alignment editor/molecular graphics tool for interactive homology modeling of proteins.

    PubMed

    Hansen, M; Bentz, J; Baucom, A; Gregoret, L

    1998-01-01

    Gaining functional information about a novel protein is a universal problem in biomedical research. With the explosive growth of the protein sequence and structural databases, it is becoming increasingly common for researchers to attempt to build a three-dimensional model of their protein of interest in order to gain information about its structure and interactions with other molecules. The two most reliable methods for predicting the structure of a protein are homology modeling, in which the novel sequence is modeled on the known three-dimensional structure of a related protein, and fold recognition (threading), where the sequence is scored against a library of fold models, and the highest scoring model is selected. The sequence alignment to a known structure can be ambiguous, and human intervention is often required to optimize the model. We describe an interactive model building and assessment tool in which a sequence alignment editor is dynamically coupled to a molecular graphics display. By means of a set of assessment tools, the user may optimize his or her alignment to satisfy the known heuristics of protein structure. Adjustments to the sequence alignment made by the user are reflected in the displayed model by color and other visual cues. For instance, residues are colored by hydrophobicity in both the three-dimensional model and in the sequence alignment. This aids the user in identifying undesirable buried polar residues. Several different evaluation metrics may be selected including residue conservation, residue properties, and visualization of predicted secondary structure. These characteristics may be mapped to the model both singly and in combination. DINAMO is a Java-based tool that may be run either over the web or installed locally. Its modular architecture also allows Java-literate users to add plug-ins of their own design.

  3. Crystal Structure of Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 Å Resolution: Dynamics of Catalytic Residues

    SciTech Connect

    Oakley, Aaron J.; Klvana, Martin; Otyepka, Michal; Nagata, Yuji; Wilce, Matthew C.J.; Damborsky, Jiri

    2010-11-16

    We present the structure of LinB, a 33-kDa haloalkane dehalogenase from Sphingomonas paucimobilis UT26, at 0.95 {angstrom} resolution. The data have allowed us to directly observe the anisotropic motions of the catalytic residues. In particular, the side-chain of the catalytic nucleophile, Asp108, displays a high degree of disorder. It has been modeled in two conformations, one similar to that observed previously (conformation A) and one strained (conformation B) that approached the catalytic base (His272). The strain in conformation B was mainly in the C{sub {alpha}}-C{sub {beta}}-C{sub {gamma}} angle (126{sup o}) that deviated by 13.4{sup o} from the 'ideal' bond angle of 112.6{sup o}. On the basis of these observations, we propose a role for the charge state of the catalytic histidine in determining the geometry of the catalytic residues. We hypothesized that double-protonation of the catalytic base (His272) reduces the distance between the side-chain of this residue and that of the Asp108. The results of molecular dynamics simulations were consistent with the structural data showing that protonation of the His272 side-chain nitrogen atoms does indeed reduce the distance between the side-chains of the residues in question, although the simulations failed to demonstrate the same degree of strain in the Asp108 C{sub {alpha}}-C{sub {beta}}-C{sub {gamma}} angle. Instead, the changes in the molecular dynamics structures were distributed over several bond and dihedral angles. Quantum mechanics calculations on LinB with 1-chloro-2,2-dimethylpropane as a substrate were performed to determine which active site conformations and protonation states were most likely to result in catalysis. It was shown that His272 singly protonated at N{sub {delta}1} and Asp108 in conformation A gave the most exothermic reaction ({Delta}H = -22 kcal/mol). With His272 doubly protonated at N{sub {delta}1} and N{sub {epsilon}2}, the reactions were only slightly exothermic or were endothermic

  4. A survey of the awareness, knowledge, policies and views of veterinary journal Editors-in-Chief on reporting guidelines for publication of research

    PubMed Central

    2014-01-01

    Background Wider adoption of reporting guidelines by veterinary journals could improve the quality of published veterinary research. The aims of this study were to assess the knowledge and views of veterinary Editors-in-Chief on reporting guidelines, identify the policies of their journals, and determine their information needs. Editors-in-Chief of 185 journals on the contact list for the International Association of Veterinary Editors (IAVE) were surveyed in April 2012 using an online questionnaire which contained both closed and open questions. Results The response rate was 36.8% (68/185). Thirty-six of 68 editors (52.9%) stated they knew what a reporting guideline was before receiving the questionnaire. Editors said they had found out about reporting guidelines primarily through articles in other journals, via the Internet and through their own journal. Twenty of 57 respondents (35.1%) said their journal referred to reporting guidelines in its instructions to authors. CONSORT, REFLECT, and ARRIVE were the most frequently cited. Forty-four of 68 respondents (68.2%) believed that reporting guidelines should be adopted by all refereed veterinary journals. Qualitative analysis of the open questions revealed that lack of knowledge, fear, resistance to change, and difficulty in implementation were perceived as barriers to the adoption of reporting guidelines by journals. Editors suggested that reporting guidelines be promoted through communication and education of the veterinary community, with roles for the IAVE and universities. Many respondents believed a consensus policy on guideline implementation was needed for veterinary journals. Conclusions Further communication and education about reporting guidelines for editors, authors and reviewers has the potential to increase their adoption by veterinary journals in the future. PMID:24410882

  5. The editor, the publisher, and his mother: the representation of lesbians and gays in the New York Times.

    PubMed

    Chomsky, Daniel; Barclay, Scott

    2013-01-01

    The attention and prominence given to issues in media outlets may affect the importance citizens attribute to them, so the actors who influence mass media coverage decisions may have political power in society generally. This article seeks to measure the relative influence of journalists, social trends, events, government officials, editors, and owners on the New York Times coverage of lesbians and gays from 1960 to 1995. Although many factors affected the nature and frequency of such coverage, the findings of this article show that the owners of the Times exerted decisive influence. Documentary evidence reveals that the Times' owners actively intervened to suppress coverage of lesbians and gays until 1987, even as reporters and editors recognized that increased social visibility made them newsworthy. Statistical analysis confirms that, although some actual events and statements of officials attracted attention from the newspaper throughout the period, they were more likely to generate prominent coverage after 1987 when the stories were consistent with the enthusiasms of the owners.

  6. "Anti-smoking data are exaggerated" versus "the data are clear and indisputable": examining letters to the editor about tobacco.

    PubMed

    Moreland-Russell, Sarah; Harris, Jenine K; Israel, Kendre; Schell, Sarah; Mohr, Anneke

    2012-01-01

    Media advocacy plays a unique role in tobacco control policy development. Letters to the editor in particular are an interesting form of media advocacy because they reflect community sentiment regarding the policy agenda and provide insight into the public debate. The authors used ethnographic context analysis to examine the techniques used by writers of 262 tobacco-related letters to the editor published in 61 newspapers across Missouri over a 2-year period when tobacco tax and smoke-free indoor air initiatives were occurring across the state. The authors found that pro-tobacco control letter writers often used didactic strategies, citing numbers and reports, to convey information and presented their training or experience as a health professional (e.g., M.D., Ph.D.) to add legitimacy to their arguments. Anti-tobacco control letter writers, in contrast, used narrative strategies to support their stance, claimed authority as a smoker or small business owner to legitimize their claims by relating to the audience, and used collectivity to capture the attention of policymakers. These results present the importance of strategic media advocacy in tobacco control. Tobacco control advocates should increase their use of narrative strategies and collectivity in order to better connect with the public and policymakers. PMID:22376195

  7. The editor, the publisher, and his mother: the representation of lesbians and gays in the New York Times.

    PubMed

    Chomsky, Daniel; Barclay, Scott

    2013-01-01

    The attention and prominence given to issues in media outlets may affect the importance citizens attribute to them, so the actors who influence mass media coverage decisions may have political power in society generally. This article seeks to measure the relative influence of journalists, social trends, events, government officials, editors, and owners on the New York Times coverage of lesbians and gays from 1960 to 1995. Although many factors affected the nature and frequency of such coverage, the findings of this article show that the owners of the Times exerted decisive influence. Documentary evidence reveals that the Times' owners actively intervened to suppress coverage of lesbians and gays until 1987, even as reporters and editors recognized that increased social visibility made them newsworthy. Statistical analysis confirms that, although some actual events and statements of officials attracted attention from the newspaper throughout the period, they were more likely to generate prominent coverage after 1987 when the stories were consistent with the enthusiasms of the owners. PMID:24059965

  8. Safer Vehicles for People and the Planet: Letter to the Editor

    SciTech Connect

    Wenzel, Thomas P; Wenzel, Thomas P; Ross, Marc

    2008-05-01

    Letter to the Editors from Leonard Evans, Bloomfield Hills, MI: Single-vehicle crashes, which account for half of occupant fatalities, are not mentioned in 'Safer Vehicles for People and the Planet', by Thomas P. Wenzel and Marc Ross (March-April). Simple physics shows that in such crashes risk declines as vehicle mass increases. The authors write 'driving imported luxury cars carries extremely low risk, for reasons that are not obvious'. The reasons are obvious--the cars are purchased by low-risk drivers. If they swapped vehicles with drivers of sports cars (which have high risk), the risks would stick with the drivers, not the vehicles. The article reflects the American belief that death on our roads can be substantially reduced by making vehicles in which it is safer to crash. From 1979 through 2002, Great Britain, Canada and Australia reduced fatalities by an average of 49 percent, compared with 16 percent in the U.S. Accumulating the differences over this time shows that by merely matching the safety performance of these other countries, about 200,000 fewer Americans would have died. These trends continue. In 2006 the U.S. recorded 42,642 traffic deaths, a modest 22 percent decline from our all-time high. Sweden recorded 445, a reduction of 66 percent from their all-time high. The obsessive focus on vehicles rather than on countermeasures that scientific research shows substantially reduce risk is at the core of our dramatic safety failure. The only way to substantially reduce deaths is to reduce the risk of crashing, not to make it safer to crash. The response from Drs. Wenzel and Ross: Of course Dr. Evans is correct in stating that driver behavior influences crash risk. In our article we made clear that our estimates of risk include how well a vehicle/driver combination avoids a crash, as well as how crash-worthy a vehicle (and robust a driver) is once a crash occurs. We also analyzed two variables that can account for driver behavior: the fraction of all

  9. Survey of editors and reviewers of high-impact psychology journals: statistical and research design problems in submitted manuscripts.

    PubMed

    Harris, Alex; Reeder, Rachelle; Hyun, Jenny

    2011-01-01

    The authors surveyed 21 editors and reviewers from major psychology journals to identify and describe the statistical and design errors they encounter most often and to get their advice regarding prevention of these problems. Content analysis of the text responses revealed themes in 3 major areas: (a) problems with research design and reporting (e.g., lack of an a priori power analysis, lack of congruence between research questions and study design/analysis, failure to adequately describe statistical procedures); (b) inappropriate data analysis (e.g., improper use of analysis of variance, too many statistical tests without adjustments, inadequate strategy for addressing missing data); and (c) misinterpretation of results. If researchers attended to these common methodological and analytic issues, the scientific quality of manuscripts submitted to high-impact psychology journals might be significantly improved.

  10. [Book review] Ecological Scale - Theory and Applications by D.L. Peterson and V. Thomas Parker, editors

    USGS Publications Warehouse

    O'Connell, A.F.

    2000-01-01

    Covering the complexity of the scale topic, this volume represents an important compilation of information on a topic that is often misunderstood, and one for which little attention is paid (although, thankfully, this seems to be on the decline). Although technical, this book provides full exposure to the scale issue in ecology and is an important reference for researchers and resource managers who are working to understand and preserve ecological function in parks. The authors and editors have combined to provide a needed examination of a very important topic. In summary, why purchase all those books on scale when just one will do? The mountain of information alone stuffed into this one book should prompt all parks to get a copy and have it on hand as a quick and ready reference.

  11. Rika-Shoshi, the First Physics Experiment Textbook Published in Japanese and its Editor, Jun'ichi Udagawa

    NASA Astrophysics Data System (ADS)

    Takahashi, Hiroshi; Akabane, Akira; Shozawa, Jun; Tamaki, Toyomi

    The aim of this study is to examine the teaching of physics experiment at elementary and secondary school levels at the time when Japanese science education commenced. In this report, we focused on the first Japanese textbook of physics experiment, Rika-Shoshi, published in 1882 and the editor of the book, Udagawa Jun'ichi. Many experiments in Rika-Shoshi can be performed using low-cost everyday materials. We compare Rika-Shoshi with the original English textbooks and describe Udagawa's physics teaching in the Gunma Normal School based on the documents in the Gunma University archives. We discuss how we can learn from physics education as taught about 130 years ago.

  12. Problems of Journalism; Proceedings of the 1975 Annual Convention of the American Society of Newspaper Editors (Washington, D.C., April 16-18, 1975).

    ERIC Educational Resources Information Center

    American Society of Newspaper Editors, Easton, PA.

    This document reports the 1975 proceedings of the American Society of Newspaper Editors (ASNE) convention held in Washington, D.C., April 16-18. The contents include a list of officers and directors, past presidents of the society, and a copy of the ASNE Code of Ethics. Also contained in the document are reports on such individual sessions as…

  13. Erratum: Letter to the Editor: Exclusion of primary congenital glaucoma (buphthalmos) from two candidate regions of chromosome arm 6p and chromosome 11

    SciTech Connect

    1996-03-01

    This {open_quotes}Letter to the Editor{close_quotes} is the reprint of a corrected table from a previous paper about the exclusion of primary congenital glaucoma from two candidate regions of chromosome arm 6p and chromosome 11.

  14. Letter to the editor for the article "Auto-injector needle length may be inadequate to deliver epinephrine intramuscularly in women with confirmed food allergy".

    PubMed

    Song, T Ted

    2014-01-01

    Letter to the Editor for "Auto-injector needle length may be inadequate to deliver epinephrine intramuscularly in women with confirmed food allergy" by Tsai et al. There are limitations of this study note mentioning such as method of compression, role of propulsion, defining those patients who are at risk of prophylaxis and future studies.

  15. Sylvia Taylor Johnson, PhD, Editor-in-Chief of "The Journal of Negro Education" (1994-2001): A World-Class Champion Runner

    ERIC Educational Resources Information Center

    Hughes, Gerunda B.; Wallace, Michael B.

    2007-01-01

    With characteristic crystal clarity and advanced, sharply honed research skills, Dr. Sylvia T. Johnson was able to take full advantage of holding the position of Editor-in-Chief of "The Journal of Negro Education" from 1994 to 2001. This article summarizes her accomplishments through the many hats she wore.

  16. Response to the Letter to the Editor of Crop Science from Donald R. Davis regarding our research article published in Crop Science (2011: 51:2721-2727)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This letter serves as a response to the Letter to the Editor submitted by Donald R. Davis regarding our research article entitled “Mineral Concentration of Broccoli Florets in Relation to Year of Cultivar Release” published in Crop Science (2011, 51:2721-2727). In our manuscript, we clearly stated ...

  17. GUEST EDITOR'S INTRODUCTION: Guest Editor's introduction

    NASA Astrophysics Data System (ADS)

    Chrysanthis, Panos K.

    1996-12-01

    Computer Science Department, University of Pittsburgh, Pittsburgh, PA 15260, USA This special issue focuses on current efforts to represent and support workflows that integrate information systems and human resources within a business or manufacturing enterprise. Workflows may also be viewed as an emerging computational paradigm for effective structuring of cooperative applications involving human users and access to diverse data types not necessarily maintained by traditional database management systems. A workflow is an automated organizational process (also called business process) which consists of a set of activities or tasks that need to be executed in a particular controlled order over a combination of heterogeneous database systems and legacy systems. Within workflows, tasks are performed cooperatively by either human or computational agents in accordance with their roles in the organizational hierarchy. The challenge in facilitating the implementation of workflows lies in developing efficient workflow management systems. A workflow management system (also called workflow server, workflow engine or workflow enactment system) provides the necessary interfaces for coordination and communication among human and computational agents to execute the tasks involved in a workflow and controls the execution orderings of tasks as well as the flow of data that these tasks manipulate. That is, the workflow management system is responsible for correctly and reliably supporting the specification, execution, and monitoring of workflows. The six papers selected (out of the twenty-seven submitted for this special issue of Distributed Systems Engineering) address different aspects of these three functional components of a workflow management system. In the first paper, `Correctness issues in workflow management', Kamath and Ramamritham discuss the important issue of correctness in workflow management that constitutes a prerequisite for the use of workflows in the automation of the critical organizational/business processes. In particular, this paper examines the issues of execution atomicity and failure atomicity, differentiating between correctness requirements of system failures and logical failures, and surveys techniques that can be used to ensure data consistency in workflow management systems. While the first paper is concerned with correctness assuming transactional workflows in which selective transactional properties are associated with individual tasks or the entire workflow, the second paper, `Scheduling workflows by enforcing intertask dependencies' by Attie et al, assumes that the tasks can be either transactions or other activities involving legacy systems. This second paper describes the modelling and specification of conditions involving events and dependencies among tasks within a workflow using temporal logic and finite state automata. It also presents a scheduling algorithm that enforces all stated dependencies by executing at any given time only those events that are allowed by all the dependency automata and in an order as specified by the dependencies. In any system with decentralized control, there is a need to effectively cope with the tension that exists between autonomy and consistency requirements. In `A three-level atomicity model for decentralized workflow management systems', Ben-Shaul and Heineman focus on the specific requirement of enforcing failure atomicity in decentralized, autonomous and interacting workflow management systems. Their paper describes a model in which each workflow manager must be able to specify the sequence of tasks that comprise an atomic unit for the purposes of correctness, and the degrees of local and global atomicity for the purpose of cooperation with other workflow managers. The paper also discusses a realization of this model in which treaties and summits provide an agreement mechanism, while underlying transaction managers are responsible for maintaining failure atomicity. The fourth and fifth papers are experience papers describing a workflow management system and a l

  18. GUEST EDITORS' INTRODUCTION: Guest Editors' introduction

    NASA Astrophysics Data System (ADS)

    Guerraoui, Rachid; Vinoski, Steve

    1997-09-01

    The organization of a distributed system can have a tremendous impact on its capabilities, its performance, and its ability to evolve to meet changing requirements. For example, the client - server organization model has proven to be adequate for organizing a distributed system as a number of distributed servers that offer various functions to client processes across the network. However, it lacks peer-to-peer capabilities, and experience with the model has been predominantly in the context of local networks. To achieve peer-to-peer cooperation in a more global context, systems issues of scale, heterogeneity, configuration management, accounting and sharing are crucial, and the complexity of migrating from locally distributed to more global systems demands new tools and techniques. An emphasis on interfaces and modules leads to the modelling of a complex distributed system as a collection of interacting objects that communicate with each other only using requests sent to well defined interfaces. Although object granularity typically varies at different levels of a system architecture, the same object abstraction can be applied to various levels of a computing architecture. Since 1989, the Object Management Group (OMG), an international software consortium, has been defining an architecture for distributed object systems called the Object Management Architecture (OMA). At the core of the OMA is a `software bus' called an Object Request Broker (ORB), which is specified by the OMG Common Object Request Broker Architecture (CORBA) specification. The OMA distributed object model fits the structure of heterogeneous distributed applications, and is applied in all layers of the OMA. For example, each of the OMG Object Services, such as the OMG Naming Service, is structured as a set of distributed objects that communicate using the ORB. Similarly, higher-level OMA components such as Common Facilities and Domain Interfaces are also organized as distributed objects that can be layered over both Object Services and the ORB. The OMG creates specifications, not code, but the interfaces it standardizes are always derived from demonstrated technology submitted by member companies. The specified interfaces are written in a neutral Interface Definition Language (IDL) that defines contractual interfaces with potential clients. Interfaces written in IDL can be translated to a number of programming languages via OMG standard language mappings so that they can be used to develop components. The resulting components can transparently communicate with other components written in different languages and running on different operating systems and machine types. The ORB is responsible for providing the illusion of `virtual homogeneity' regardless of the programming languages, tools, operating systems and networks used to realize and support these components. With the adoption of the CORBA 2.0 specification in 1995, these components are able to interoperate across multi-vendor CORBA-based products. More than 700 member companies have joined the OMG, including Hewlett-Packard, Digital, Siemens, IONA Technologies, Netscape, Sun Microsystems, Microsoft and IBM, which makes it the largest standards body in existence. These companies continue to work together within the OMG to refine and enhance the OMA and its components. This special issue of Distributed Systems Engineering publishes five papers that were originally presented at the `Distributed Object-Based Platforms' track of the 30th Hawaii International Conference on System Sciences (HICSS), which was held in Wailea on Maui on 6 - 10 January 1997. The papers, which were selected based on their quality and the range of topics they cover, address different aspects of CORBA, including advanced aspects such as fault tolerance and transactions. These papers discuss the use of CORBA and evaluate CORBA-based development for different types of distributed object systems and architectures. The first paper, by S Rahkila and S Stenberg, discusses the application of CORBA to telecommunication management networks. In the second paper, P Narasimhan, L E Moser and P M Melliar-Smith present a fault-tolerant extension of an ORB. The third paper, by J Liang, S Sédillot and B Traverson, provides an overview of the CORBA Transaction Service and its integration with the ISO Distributed Transaction Processing protocol. In the fourth paper, D Sherer, T Murer and A Würtz discuss the evolution of a cooperative software engineering infrastructure to a CORBA-based framework. The fifth paper, by R Fatoohi, evaluates the communication performance of a commercially-available Object Request Broker (Orbix from IONA Technologies) on several networks, and compares the performance with that of more traditional communication primitives (e.g., BSD UNIX sockets and PVM). We wish to thank both the referees and the authors of these papers, as their cooperation was fundamental in ensuring timely publication.

  19. GUEST EDITOR'S INTRODUCTION: Guest Editor's introduction

    NASA Astrophysics Data System (ADS)

    Chrysanthis, Panos K.

    1996-12-01

    Computer Science Department, University of Pittsburgh, Pittsburgh, PA 15260, USA This special issue focuses on current efforts to represent and support workflows that integrate information systems and human resources within a business or manufacturing enterprise. Workflows may also be viewed as an emerging computational paradigm for effective structuring of cooperative applications involving human users and access to diverse data types not necessarily maintained by traditional database management systems. A workflow is an automated organizational process (also called business process) which consists of a set of activities or tasks that need to be executed in a particular controlled order over a combination of heterogeneous database systems and legacy systems. Within workflows, tasks are performed cooperatively by either human or computational agents in accordance with their roles in the organizational hierarchy. The challenge in facilitating the implementation of workflows lies in developing efficient workflow management systems. A workflow management system (also called workflow server, workflow engine or workflow enactment system) provides the necessary interfaces for coordination and communication among human and computational agents to execute the tasks involved in a workflow and controls the execution orderings of tasks as well as the flow of data that these tasks manipulate. That is, the workflow management system is responsible for correctly and reliably supporting the specification, execution, and monitoring of workflows. The six papers selected (out of the twenty-seven submitted for this special issue of Distributed Systems Engineering) address different aspects of these three functional components of a workflow management system. In the first paper, `Correctness issues in workflow management', Kamath and Ramamritham discuss the important issue of correctness in workflow management that constitutes a prerequisite for the use of workflows in the automation of the critical organizational/business processes. In particular, this paper examines the issues of execution atomicity and failure atomicity, differentiating between correctness requirements of system failures and logical failures, and surveys techniques that can be used to ensure data consistency in workflow management systems. While the first paper is concerned with correctness assuming transactional workflows in which selective transactional properties are associated with individual tasks or the entire workflow, the second paper, `Scheduling workflows by enforcing intertask dependencies' by Attie et al, assumes that the tasks can be either transactions or other activities involving legacy systems. This second paper describes the modelling and specification of conditions involving events and dependencies among tasks within a workflow using temporal logic and finite state automata. It also presents a scheduling algorithm that enforces all stated dependencies by executing at any given time only those events that are allowed by all the dependency automata and in an order as specified by the dependencies. In any system with decentralized control, there is a need to effectively cope with the tension that exists between autonomy and consistency requirements. In `A three-level atomicity model for decentralized workflow management systems', Ben-Shaul and Heineman focus on the specific requirement of enforcing failure atomicity in decentralized, autonomous and interacting workflow management systems. Their paper describes a model in which each workflow manager must be able to specify the sequence of tasks that comprise an atomic unit for the purposes of correctness, and the degrees of local and global atomicity for the purpose of cooperation with other workflow managers. The paper also discusses a realization of this model in which treaties and summits provide an agreement mechanism, while underlying transaction managers are responsible for maintaining failure atomicity. The fourth and fifth papers are experience papers describing a workflow management system and a large scale workflow application, respectively. Schill and Mittasch, in `Workflow management systems on top of OSF DCE and OMG CORBA', describe a decentralized workflow management system and discuss its implementation using two standardized middleware platforms, namely, OSF DCE and OMG CORBA. The system supports a new approach to workflow management, introducing several new concepts such as data type management for integrating various types of data and quality of service for various services provided by servers. A problem common to both database applications and workflows is the handling of missing and incomplete information. This is particularly pervasive in an `electronic market' with a huge number of retail outlets producing and exchanging volumes of data, the application discussed in `Information flow in the DAMA project beyond database managers: information flow managers'. Motivated by the need for a method that allows a task to proceed in a timely manner if not all data produced by other tasks are available by its deadline, Russell et al propose an architectural framework and a language that can be used to detect, approximate and, later on, to adjust missing data if necessary. The final paper, `The evolution towards flexible workflow systems' by Nutt, is complementary to the other papers and is a survey of issues and of work related to both workflow and computer supported collaborative work (CSCW) areas. In particular, the paper provides a model and a categorization of the dimensions which workflow management and CSCW systems share. Besides summarizing the recent advancements towards efficient workflow management, the papers in this special issue suggest areas open to investigation and it is our hope that they will also provide the stimulus for further research and development in the area of workflow management systems.

  20. GUEST EDITORS' INTRODUCTION: Guest Editors' introduction

    NASA Astrophysics Data System (ADS)

    Coulson, Geoff; de Meer, Jan B.

    1997-03-01

    Quality of Service (QoS) has emerged in the last few years as a topical and challenging research area in distributed systems. For a broad definition of QoS we refer to the ISO's Reference Model for Open Distributed Processing (ISO/IEC IS 10746-2): `The notion of QoS is a system or object property, and consists of a set of quality requirements on the collective behaviour of one or more objects . . .'. In the context of this special issue, QoS is primarily associated with systems such as distributed multimedia application platforms or distributed simulations. The QoS requirements of such systems typically relate to measures of rate and latency of information transfer, probability of a communication being disrupted, probability of system failure, probability of storage failure, etc. The role of QoS management is thus to ensure that applications are able to specify and obtain the quality of service that they require for their correct execution. In general, the functions of QoS management may be subsumed under the following headings: (i) QoS specification and mapping, (ii) QoS negotiation, resource allocation and admission control and (iii) QoS monitoring, adaptation and renegotiation. QoS specification defines the QoS required by an application in terms of both timeliness constraints and guarantees. QoS mapping then translates between QoS representations at different system levels, relieving the user of the necessity of thinking in terms of low-level QoS representations. For example, a user may express a jitter requirement by manipulating a slider in a GUI, and this could be mapped at the lower layers into a requirement for an absolute bound on ATM cell jitter and a jitter smoothing buffer of a certain size. QoS negotiation, resource allocation and admission control are collectively responsible for configuring a system in preparation for the execution of a QoS requiring application. QoS negotiation provides a framework in which the QoS levels supported by individual system components (e.g. file server, operating system and network) are composed to build the required end-to-end service. Providing such a service may well require explicit resource allocation (e.g. of network bandwidth or CPU cycles); admission control may also be required to ensure that requested QoS levels can be met. QoS monitoring, adaptation and renegotiation are concerned with supporting QoS during the run time of an application. QoS monitoring and QoS adaptation are conceptually related in a feedback loop in which current QoS levels are observed and fine grained reconfiguration is triggered as necessary to ensure that the required levels are maintained. An example of such a loop is to be found in Internet tools such as vic or vat which monitor network delay and adapt by adjusting the size of an elastic playout buffer. QoS renegotiation is a coarser grained adaptation, often explicitly initiated by the user, in which required QoS levels are revised at run time. An example could be a user scaling a video display from colour to monochrome so that sufficient resources can be freed to support an additional connection. The papers in this special issue were selected from the fourth QoS Workshop held in Paris in March 1996. To understand the overall evolution of QoS research it is useful to know some background on the series of workshops of which the Paris workshop was a part. The first workshop to be dedicated exclusively to QoS issues was organized in Canada by the European RACE project R2088 (TOPIC) in cooperation with the University of Montreal in June 1994. A European counterpart of this initiating event occurred in the same year in September 1994 in Aachen, Germany. This latter event was held in cooperation with the European Conference on Intelligence in Broadband Services and Networks (IS&N94). A third workshop was then held in conjunction with the IFIP conference on Open Distributed Processing (ICODP95) in Brisbane, Australia in March 1995. By 1996 more independence, and also more recognition of QoS as an independent research area, was achieved in the

  1. Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality*

    PubMed Central

    Francisco, Adam B.; Singh, Rajni; Li, Shuai; Vani, Anish K.; Yang, Liu; Munroe, Robert J.; Diaferia, Giuseppe; Cardano, Marina; Biunno, Ida; Qi, Ling; Schimenti, John C.; Long, Qiaoming

    2010-01-01

    Stress in the endoplasmic reticulum (ER) plays an important causal role in the pathogenesis of several chronic diseases such as Alzheimer, Parkinson, and diabetes mellitus. Insight into the genetic determinants responsible for ER homeostasis will greatly facilitate the development of therapeutic strategies for the treatment of these debilitating diseases. Suppressor enhancer Lin12 1 like (SEL1L) is an ER membrane protein and was thought to be involved in the quality control of secreted proteins. Here we show that the mice homozygous mutant for SEL1L were embryonic lethal. Electron microscopy studies revealed a severely dilated ER in the fetal liver of mutant embryos, indicative of alteration in ER homeostasis. Consistent with this, several ER stress responsive genes were significantly up-regulated in the mutant embryos. Mouse embryonic fibroblast cells deficient in SEL1L exhibited activated unfolded protein response at the basal state, impaired ER-associated protein degradation, and reduced protein secretion. Furthermore, markedly increased apoptosis was observed in the forebrain and dorsal root ganglions of mutant embryos. Taken together, our results demonstrate an essential role for SEL1L in protein quality control during mouse embryonic development. PMID:20197277

  2. Cloning of a CACTA transposon-like insertion in intron I of tomato invertase Lin5 gene and identification of transposase-like sequences of Solanaceae species.

    PubMed

    Proels, Reinhard K; Roitsch, Thomas

    2006-03-01

    Very few CACTA transposon-like sequences have been described in Solanaceae species. Sequence information has been restricted to partial transposase (TPase)-like fragments, and no target gene of CACTA-like transposon insertion has been described in tomato to date. In this manuscript, we report on a CACTA transposon-like insertion in intron I of tomato (Lycopersicon esculentum) invertase gene Lin5 and TPase-like sequences of several Solanaceae species. Consensus primers deduced from the TPase region of the tomato CACTA transposon-like element allowed the amplification of similar sequences from various Solanaceae species of different subfamilies including Solaneae (Solanum tuberosum), Cestreae (Nicotiana tabacum) and Datureae (Datura stramonium). This demonstrates the ubiquitous presence of CACTA-like elements in Solanaceae genomes. The obtained partial sequences are highly conserved, and allow further detection and detailed analysis of CACTA-like transposons throughout Solanaceae species. CACTA-like transposon sequences make possible the evaluation of their use for genome analysis, functional studies of genes and the evolutionary relationships between plant species.

  3. Release of halide ions from the buried active site of the haloalkane dehalogenase LinB revealed by stopped-flow fluorescence analysis and free energy calculations.

    PubMed

    Hladilkova, Jana; Prokop, Zbynek; Chaloupkova, Radka; Damborsky, Jiri; Jungwirth, Pavel

    2013-11-21

    Release of halide ions is an essential step of the catalytic cycle of haloalkane dehalogenases. Here we describe experimentally and computationally the process of release of a halide anion from the buried active site of the haloalkane dehalogenase LinB. Using stopped-flow fluorescence analysis and umbrella sampling free energy calculations, we show that the anion binding is ion-specific and follows the ordering I(-) > Br(-) > Cl(-). We also address the issue of the protonation state of the catalytic His272 residue and its effect on the process of halide release. While deprotonation of His272 increases binding of anions in the access tunnel, we show that the anionic ordering does not change with the switch of the protonation state. We also demonstrate that a sodium cation could relatively easily enter the active site, provided the His272 residue is singly protonated, and replace thus the missing proton. In contrast, Na(+) is strongly repelled from the active site containing the doubly protonated His272 residue. Our study contributes toward understanding of the reaction mechanism of haloalkane dehalogenase enzyme family. Determination of the protonation state of the catalytic histidine throughout the catalytic cycle remains a challenge for future studies.

  4. Tuber melanosporum fermentation medium optimization by Plackett-Burman design coupled with Draper-Lin small composite design and desirability function.

    PubMed

    Liu, Rui-Sang; Tang, Ya-Jie

    2010-05-01

    A novel method using Plackett-Burman design (PBD) coupled with Draper-Lin small composite design (SCD) and desirability function (DF) was developed to optimize Tuber melanosporum fermentation medium. Firstly, sucrose, yeast extract, peptone and Mg(2+) were identified to be key medium components by PBD. Secondly, in order to evaluate the relationships between responses and the identified key components, mathematical models were developed by SCD. Finally, by using DF, the responses were optimized simultaneously and the optimal concentration was located to be 73 g/L sucrose, 11 g/L yeast extract, 8 g/L peptone, and 46 mM Mg(2+). Under the identified optimal conditions, the maximal biomass, the production of extracellular (EPS) and intracellular (IPS) polysaccharides was 25.10 + or - 0.12 g/L, 3.88 + or - 0.23 g/L and 2.87 + or - 0.32 g/L, respectively, which agreed with the predicted values well. Compared with the basic medium, the biomass, the production of EPS and IPS was enhanced by 54.4%, 71.7% and 124.2%, respectively.

  5. FORMATION OF MOONLETS IN SATURN'S RINGS: THE ROLE OF THE CONSTRUCTIVE INTERFERENCE OF LIN-SHU-TYPE CIRCULAR AND SPIRAL DENSITY WAVES

    SciTech Connect

    Griv, Evgeny

    2011-05-20

    Localized kilometer-sized propeller features, recently detected in CASSINI images of Saturn's A ring, may be interpreted as signatures of small hundred-meter-sized moonlets embedded within the broad ring. We propose that these moonlets are formed due to the constructive interference of the gravitationally unstable axisymmetric and nonaxisymmetric perturbations of the self-gravitating Saturnian ring disk. The hydrodynamical slab model of the disk is studied to determine its instability against low-frequency compression-type, or Lin-Shu-type, oscillations whose propagation vector is perpendicular to the axis of the disk's rotation. The linear instability analysis is performed in the following way. First, we derive the general dispersion relation for the gravity perturbations inside the slab within the standard local short-wavelength approach. Next, we match the solutions to the solutions of the Poisson equation outside the slab to arrive at the particular dispersion relation. The particular dispersion relation describes the development of symmetric Jeans' perturbations which cause density enhancements. From this dispersion relation, the growth rate of Jeans-unstable oscillations developing in the spatially homogeneous slab model is obtained. The dispersion relation shows that perturbations of both types, axisymmetric and nonaxisymmetric, are excited simultaneously due to the Jeans' gravitational instability. As a result, circular and spiral patterns develop. We suggest that clumping occurs due to the enhanced density increase at the intersections of the patterns. We also speculate that these clumps further develop into propeller moonlets.

  6. Caenorhabditis elegans Histone Deacetylase hda-1 Is Required for Morphogenesis of the Vulva and LIN-12/Notch-Mediated Specification of Uterine Cell Fates

    PubMed Central

    Ranawade, Ayush Vasant; Cumbo, Philip; Gupta, Bhagwati P.

    2013-01-01

    Chromatin modification genes play crucial roles in development and disease. In Caenorhabditis elegans, the class I histone deacetylase family member hda-1, a component of the nucleosome remodeling and deacetylation complex, has been shown to control cell proliferation. We recovered hda-1 in an RNA interference screen for genes involved in the morphogenesis of the egg-laying system. We found that hda-1 mutants have abnormal vulva morphology and vulval-uterine connections (i.e., no uterine-seam cell). We characterized the vulval defects by using cell fate-specific markers and found that hda-1 is necessary for the specification of all seven vulval cell types. The analysis of the vulval-uterine connection defect revealed that hda-1 is required for the differentiation of the gonadal anchor cell (AC), which in turn induces ventral uterine granddaughters to adopt π fates, leading to the formation of the uterine-seam cell. Consistent with these results, hda-1 is expressed in the vulva and AC. A search for hda-1 target genes revealed that fos-1 (fos proto-oncogene family) acts downstream of hda-1 in vulval cells, whereas egl-43 (evi1 proto-oncogene family) and nhr-67 (tailless homolog, NHR family) mediate hda-1 function in the AC. Furthermore, we showed that AC expression of hda-1 plays a crucial role in the regulation of the lin-12/Notch ligand lag-2 to specify π cell fates. These results demonstrate the pivotal role of hda-1 in the formation of the vulva and the vulval-uterine connection. Given that hda-1 homologs are conserved across the phyla, our findings are likely to provide a better understanding of HDAC1 function in development and disease. PMID:23797102

  7. Atmospheric CO2 and its δ13C measurements from flask sampling at Lin'an regional background station in China

    NASA Astrophysics Data System (ADS)

    Xia, Lingjun; Zhou, Lingxi; Tans, Pieter P.; Liu, Lixin; Zhang, Gen; Wang, Hongyang; Luan, Tian

    2015-09-01

    This study presents CO2 concentrations of air flask samples obtained at a regional background station Lin'an (LAN) in China from January 2009 to December 2013, as well as their stable isotope ratios (δ13C) from January 2011 to December 2013. Background data is selected to represent background characteristics of atmospheric CO2 and δ13C over Yangzte River Delta. The annual mean background CO2 concentrations vary from 395.0 ppm in 2009 to 407.6 ppm in 2013, with a growth rate of 2.8 ± 0.1 ppm yr-1 over the study period, which is higher than the global average level. The annual mean values of δ13C vary from -8.55‰ in 2011 to -8.73‰ in 2013, with a growth rate of -0.029 ± 0.010‰ yr-1. Seasonal cycles of CO2 concentrations and δ13C are observed to be obvious at LAN. The minimum and maximum values of mean seasonal CO2 cycle appear in August and January, respectively, with the peak-to-peak amplitude of 19.4 ppm. The sign of δ13C seasonal cycle is opposite to that of CO2, and the peak-to-peak amplitude is 0.85‰. The isotopic signature of CO2 sources/sinks (δs) is also discussed in this paper. The estimated δs values for heating season (December-February) is -25.4‰ and for vegetative season is -21.3‰ (March-November) suggest the significant impact of fossil fuel combustions during winter heating season and biological activities during vegetative season.

  8. Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors' Expert Forum.

    PubMed

    Cefalu, William T; Bray, George A; Home, Philip D; Garvey, W Timothy; Klein, Samuel; Pi-Sunyer, F Xavier; Hu, Frank B; Raz, Itamar; Van Gaal, Luc; Wolfe, Bruce M; Ryan, Donna H

    2015-08-01

    As obesity rates increase, so too do the risks of type 2 diabetes, cardiovascular disease, and numerous other detrimental conditions. The prevalence of obesity in U.S. adults more than doubled between 1980 and 2010, from 15.0 to 36.1%. Although this trend may be leveling off, obesity and its individual, societal, and economic costs remain of grave concern. In June 2014, a Diabetes Care Editors' Expert Forum convened to review the state of obesity research and discuss the latest prevention initiatives and behavioral, medical, and surgical therapies. This article, an outgrowth of the forum, offers an expansive view of the obesity epidemic, beginning with a discussion of its root causes. Recent insights into the genetic and physiological factors that influence body weight are reviewed, as are the pathophysiology of obesity-related metabolic dysfunction and the concept of metabolically healthy obesity. The authors address the crucial question of how much weight loss is necessary to yield meaningful benefits. They describe the challenges of behavioral modification and predictors of its success. The effects of diabetes pharmacotherapies on body weight are reviewed, including potential weight-neutral combination therapies. The authors also summarize the evidence for safety and efficacy of pharmacotherapeutic and surgical obesity treatments. The article concludes with an impassioned call for researchers, clinicians, governmental agencies, health policymakers, and health-related industries to collectively embrace the urgent mandate to improve prevention and treatment and for society at large to acknowledge and manage obesity as a serious disease. PMID:26421334

  9. [52th Commemoration of French Journal of Plastic Aesthetic Surgery (1956-2007). Fifty-four years of editorial; five Editors-in-chief].

    PubMed

    Cariou, J-L

    2007-08-01

    The french Society of Plastic Reconstructive and Aesthetic Surgery (SOF.CPRE) is born December 3th 1952. Initially without "aesthetic", this "key-word" is agreed in 1983 and the symbols are advanced since: SFCPR, SFCPRE, SOF.CPRE. Its official organ, formerly included in Annales de chirurgie (1954-1955), become Annales de chirurgie plastique in 1956, Annales de chirurgie plastique et esthétique in 1983 and finally Annales de chirurgie plastique esthétique (ACPE) in 1992. Since the origin, five Editors-in-chief succeded: Claude Dufourmentel, Raymond Vilain, Jean-Pierre Lalardrie, Claude Lê-Quang, Jean-Luc Cariou. Four of them are alive, Raymond Vilain is dead. The author relate here the natural story of these five editors who had all a triple route: personnal, surgical and editorial.

  10. One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies.

    PubMed

    Yuan, Shuai; Johnston, H Richard; Zhang, Guosheng; Li, Yun; Hu, Yi-Juan; Qin, Zhaohui S

    2015-08-01

    With rapid decline of the sequencing cost, researchers today rush to embrace whole genome sequencing (WGS), or whole exome sequencing (WES) approach as the next powerful tool for relating genetic variants to human diseases and phenotypes. A fundamental step in analyzing WGS and WES data is mapping short sequencing reads back to the reference genome. This is an important issue because incorrectly mapped reads affect the downstream variant discovery, genotype calling and association analysis. Although many read mapping algorithms have been developed, the majority of them uses the universal reference genome and do not take sequence variants into consideration. Given that genetic variants are ubiquitous, it is highly desirable if they can be factored into the read mapping procedure. In this work, we developed a novel strategy that utilizes genotypes obtained a priori to customize the universal haploid reference genome into a personalized diploid reference genome. The new strategy is implemented in a program named RefEditor. When applying RefEditor to real data, we achieved encouraging improvements in read mapping, variant discovery and genotype calling. Compared to standard approaches, RefEditor can significantly increase genotype calling consistency (from 43% to 61% at 4X coverage; from 82% to 92% at 20X coverage) and reduce Mendelian inconsistency across various sequencing depths. Because many WGS and WES studies are conducted on cohorts that have been genotyped using array-based genotyping platforms previously or concurrently, we believe the proposed strategy will be of high value in practice, which can also be applied to the scenario where multiple NGS experiments are conducted on the same cohort. The RefEditor sources are available at https://github.com/superyuan/refeditor.

  11. Why Japanese publishers are behind in making journals online? : Library needs assesment may bring up new business models : Interview with Wataru Hoshino, director at The Japan Society of Publishing Studies and director editor in chief at The Bunka Tushin

    NASA Astrophysics Data System (ADS)

    Morita, Utako

    Why Japanese publishers are behind in making journals online? : Library needs assesment may bring up new business models : Interview with Wataru Hoshino, director at The Japan Society of Publishing Studies and director editor in chief at The Bunka Tushin

  12. WebProtégé: A Collaborative Ontology Editor and Knowledge Acquisition Tool for the Web.

    PubMed

    Tudorache, Tania; Nyulas, Csongor; Noy, Natalya F; Musen, Mark A

    2013-01-01

    In this paper, we present WebProtégé-a lightweight ontology editor and knowledge acquisition tool for the Web. With the wide adoption of Web 2.0 platforms and the gradual adoption of ontologies and Semantic Web technologies in the real world, we need ontology-development tools that are better suited for the novel ways of interacting, constructing and consuming knowledge. Users today take Web-based content creation and online collaboration for granted. WebProtégé integrates these features as part of the ontology development process itself. We tried to lower the entry barrier to ontology development by providing a tool that is accessible from any Web browser, has extensive support for collaboration, and a highly customizable and pluggable user interface that can be adapted to any level of user expertise. The declarative user interface enabled us to create custom knowledge-acquisition forms tailored for domain experts. We built WebProtégé using the existing Protégé infrastructure, which supports collaboration on the back end side, and the Google Web Toolkit for the front end. The generic and extensible infrastructure allowed us to easily deploy WebProtégé in production settings for several projects. We present the main features of WebProtégé and its architecture and describe briefly some of its uses for real-world projects. WebProtégé is free and open source. An online demo is available at http://webprotege.stanford.edu.

  13. WebProtégé: A Collaborative Ontology Editor and Knowledge Acquisition Tool for the Web

    PubMed Central

    Tudorache, Tania; Nyulas, Csongor; Noy, Natalya F.; Musen, Mark A.

    2012-01-01

    In this paper, we present WebProtégé—a lightweight ontology editor and knowledge acquisition tool for the Web. With the wide adoption of Web 2.0 platforms and the gradual adoption of ontologies and Semantic Web technologies in the real world, we need ontology-development tools that are better suited for the novel ways of interacting, constructing and consuming knowledge. Users today take Web-based content creation and online collaboration for granted. WebProtégé integrates these features as part of the ontology development process itself. We tried to lower the entry barrier to ontology development by providing a tool that is accessible from any Web browser, has extensive support for collaboration, and a highly customizable and pluggable user interface that can be adapted to any level of user expertise. The declarative user interface enabled us to create custom knowledge-acquisition forms tailored for domain experts. We built WebProtégé using the existing Protégé infrastructure, which supports collaboration on the back end side, and the Google Web Toolkit for the front end. The generic and extensible infrastructure allowed us to easily deploy WebProtégé in production settings for several projects. We present the main features of WebProtégé and its architecture and describe briefly some of its uses for real-world projects. WebProtégé is free and open source. An online demo is available at http://webprotege.stanford.edu. PMID:23807872

  14. Cyclohexane-1,2-dione hydrolase from denitrifying Azoarcus sp. strain 22Lin, a novel member of the thiamine diphosphate enzyme family.

    PubMed

    Steinbach, Alma K; Fraas, Sonja; Harder, Jens; Tabbert, Anja; Brinkmann, Henner; Meyer, Axel; Ermler, Ulrich; Kroneck, Peter M H

    2011-12-01

    Alicyclic compounds with hydroxyl groups represent common structures in numerous natural compounds, such as terpenes and steroids. Their degradation by microorganisms in the absence of dioxygen may involve a C-C bond ring cleavage to form an aliphatic intermediate that can be further oxidized. The cyclohexane-1,2-dione hydrolase (CDH) (EC 3.7.1.11) from denitrifying Azoarcus sp. strain 22Lin, grown on cyclohexane-1,2-diol as a sole electron donor and carbon source, is the first thiamine diphosphate (ThDP)-dependent enzyme characterized to date that cleaves a cyclic aliphatic compound. The degradation of cyclohexane-1,2-dione (CDO) to 6-oxohexanoate comprises the cleavage of a C-C bond adjacent to a carbonyl group, a typical feature of reactions catalyzed by ThDP-dependent enzymes. In the subsequent NAD(+)-dependent reaction, 6-oxohexanoate is oxidized to adipate. CDH has been purified to homogeneity by the criteria of gel electrophoresis (a single band at ∼59 kDa; calculated molecular mass, 64.5 kDa); in solution, the enzyme is a homodimer (∼105 kDa; gel filtration). As isolated, CDH contains 0.8 ± 0.05 ThDP, 1.0 ± 0.02 Mg(2+), and 1.0 ± 0.015 flavin adenine dinucleotide (FAD) per monomer as a second organic cofactor, the role of which remains unclear. Strong reductants, Ti(III)-citrate, Na(+)-dithionite, and the photochemical 5-deazaflavin/oxalate system, led to a partial reduction of the FAD chromophore. The cleavage product of CDO, 6-oxohexanoate, was also a substrate; the corresponding cyclic 1,3- and 1,4-diones did not react with CDH, nor did the cis- and trans-cyclohexane diols. The enzymes acetohydroxyacid synthase (AHAS) from Saccharomyces cerevisiae, pyruvate oxidase (POX) from Lactobacillus plantarum, benzoylformate decarboxylase from Pseudomonas putida, and pyruvate decarboxylase from Zymomonas mobilis were identified as the closest relatives of CDH by comparative amino acid sequence analysis, and a ThDP binding motif and a 2-fold Rossmann fold

  15. Cyclohexane-1,2-Dione Hydrolase from Denitrifying Azoarcus sp. Strain 22Lin, a Novel Member of the Thiamine Diphosphate Enzyme Family▿†

    PubMed Central

    Steinbach, Alma K.; Fraas, Sonja; Harder, Jens; Tabbert, Anja; Brinkmann, Henner; Meyer, Axel; Ermler, Ulrich; Kroneck, Peter M. H.

    2011-01-01

    Alicyclic compounds with hydroxyl groups represent common structures in numerous natural compounds, such as terpenes and steroids. Their degradation by microorganisms in the absence of dioxygen may involve a C—C bond ring cleavage to form an aliphatic intermediate that can be further oxidized. The cyclohexane-1,2-dione hydrolase (CDH) (EC 3.7.1.11) from denitrifying Azoarcus sp. strain 22Lin, grown on cyclohexane-1,2-diol as a sole electron donor and carbon source, is the first thiamine diphosphate (ThDP)-dependent enzyme characterized to date that cleaves a cyclic aliphatic compound. The degradation of cyclohexane-1,2-dione (CDO) to 6-oxohexanoate comprises the cleavage of a C—C bond adjacent to a carbonyl group, a typical feature of reactions catalyzed by ThDP-dependent enzymes. In the subsequent NAD+-dependent reaction, 6-oxohexanoate is oxidized to adipate. CDH has been purified to homogeneity by the criteria of gel electrophoresis (a single band at ∼59 kDa; calculated molecular mass, 64.5 kDa); in solution, the enzyme is a homodimer (∼105 kDa; gel filtration). As isolated, CDH contains 0.8 ± 0.05 ThDP, 1.0 ± 0.02 Mg2+, and 1.0 ± 0.015 flavin adenine dinucleotide (FAD) per monomer as a second organic cofactor, the role of which remains unclear. Strong reductants, Ti(III)-citrate, Na+-dithionite, and the photochemical 5-deazaflavin/oxalate system, led to a partial reduction of the FAD chromophore. The cleavage product of CDO, 6-oxohexanoate, was also a substrate; the corresponding cyclic 1,3- and 1,4-diones did not react with CDH, nor did the cis- and trans-cyclohexane diols. The enzymes acetohydroxyacid synthase (AHAS) from Saccharomyces cerevisiae, pyruvate oxidase (POX) from Lactobacillus plantarum, benzoylformate decarboxylase from Pseudomonas putida, and pyruvate decarboxylase from Zymomonas mobilis were identified as the closest relatives of CDH by comparative amino acid sequence analysis, and a ThDP binding motif and a 2-fold Rossmann fold for

  16. Letter to the Editor

    PubMed Central

    Tuchin, Peter; Perle, Stephen

    2016-01-01

    In reviewing Melikyan et al., we discuss what we think are weaknesses in the case report. The authors did not report on known risk factors for cerebrovascular accident and vertebral artery dissection. Known symptoms that appear early in vertebral artery dissection were not reported or denied, specifically related to changes in the patient's pattern of neck pain. Causality was assumed when only a weak temporal relation was involved. Finally, the case report makes it appear that the manipulation was performed by someone other than a chiropractor but therefore erroneously uses chiropractic in the title. PMID:27413722

  17. FOREWORD: EDITORS' INTRODUCTION.

    PubMed

    Pinto, Ângelo Parise; Monné, Marcela L; Paulson, Dennis R; Takiya, Daniela M; Calor, Adolfo R; Duarte, Marcelo; Salles, Frederico F; Nihei, Silvio S

    2016-01-01

    Since its establishment ZOOTAXA has become not only a rapid journal for zoological systematics but also a respected forum for discussions of all taxonomic matters, and it has gradually attained a distinguished position among other zoological journals by its special issues. These collections of papers treat varied themes such as the Carl Linnaeus legacy (Zhang & Shear 2007, Minelli et al. 2008), cataloguing metazoan life (Zhang 2011, 2013), and promoting and discussing the future of taxonomic sciences, for example modification of the International Code of Zoological Nomenclature (ICZN 2008). For these reasons we offer this special issue to celebrate the fruitful career of the eminent Brazilian researcher Dr. Angelo Barbosa Monteiro Machado ("Professor Angelo" to his friends and colleagues).

  18. FOREWORD: EDITORS' INTRODUCTION.

    PubMed

    Pinto, Ângelo Parise; Monné, Marcela L; Paulson, Dennis R; Takiya, Daniela M; Calor, Adolfo R; Duarte, Marcelo; Salles, Frederico F; Nihei, Silvio S

    2016-01-01

    Since its establishment ZOOTAXA has become not only a rapid journal for zoological systematics but also a respected forum for discussions of all taxonomic matters, and it has gradually attained a distinguished position among other zoological journals by its special issues. These collections of papers treat varied themes such as the Carl Linnaeus legacy (Zhang & Shear 2007, Minelli et al. 2008), cataloguing metazoan life (Zhang 2011, 2013), and promoting and discussing the future of taxonomic sciences, for example modification of the International Code of Zoological Nomenclature (ICZN 2008). For these reasons we offer this special issue to celebrate the fruitful career of the eminent Brazilian researcher Dr. Angelo Barbosa Monteiro Machado ("Professor Angelo" to his friends and colleagues). PMID:27395959

  19. Guest editor's note

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sediment transport processes in rivers are of great concern in many practical studies ranging from large-scale problems such as reservoir management, dam removal, and design of restoration works to small-scale problems such as local bed scour around intakes, outfalls and piers. Within the discipline...

  20. Guest Editors' introduction

    NASA Astrophysics Data System (ADS)

    Magee, Jeff; Moffett, Jonathan

    1996-06-01

    Special Issue on Management This special issue contains seven papers originally presented at an International Workshop on Services for Managing Distributed Systems (SMDS'95), held in September 1995 in Karslruhe, Germany. The workshop was organized to present the results of two ESPRIT III funded projects, Sysman and IDSM, and more generally to bring together work in the area of distributed systems management. The workshop focused on the tools and techniques necessary for managing future large-scale, multi-organizational distributed systems. The open call for papers attracted a large number of submissions and the subsequent attendance at the workshop, which was larger than expected, clearly indicated that the topics addressed by the workshop were of considerable interest both to industry and academia. The papers selected for this special issue represent an excellent coverage of the issues addressed by the workshop. A particular focus of the workshop was the need to help managers deal with the size and complexity of modern distributed systems by the provision of automated support. This automation must have two prime characteristics: it must provide a flexible management system which responds rapidly to changing organizational needs, and it must provide both human managers and automated management components with the information that they need, in a form which can be used for decision-making. These two characteristics define the two main themes of this special issue. To satisfy the requirement for a flexible management system, workers in both industry and universities have turned to architectures which support policy directed management. In these architectures policy is explicitly represented and can be readily modified to meet changing requirements. The paper `Towards implementing policy-based systems management' by Meyer, Anstötz and Popien describes an approach whereby policy is enforced by event-triggered rules. Krause and Zimmermann in their paper `Implementing configuration management policies for distributed applications' present a system in which the configuration of the system in terms of its constituent components and their interconnections can be controlled by reconfiguration rules. Neumair and Wies in the paper `Case study: applying management policies to manage distributed queuing systems' examine how high-level policies can be transformed into practical and efficient implementations for the case of distributed job queuing systems. Koch and Krämer in `Rules and agents for automated management of distributed systems' describe the results of an experiment in using the software development environment Marvel to provide a rule based implementation of management policy. The paper by Jardin, `Supporting scalability and flexibility in a distributed management platform' reports on the experience of using a policy directed approach in the industrial strength TeMIP management platform. Both human managers and automated management components rely on a comprehensive monitoring system to provide accurate and timely information on which decisions are made to modify the operation of a system. The monitoring service must deal with condensing and summarizing the vast amount of data available to produce the events of interest to the controlling components of the overall management system. The paper `Distributed intelligent monitoring and reporting facilities' by Pavlou, Mykoniatis and Sanchez describes a flexible monitoring system in which the monitoring agents themselves are policy directed. Their monitoring system has been implemented in the context of the OSIMIS management platform. Debski and Janas in `The SysMan monitoring service and its management environment' describe the overall SysMan management system architecture and then concentrate on how event processing and distribution is supported in that architecture. The collection of papers gives a good overview of the current state of the art in distributed system management. It has reached a point at which a first generation of systems, based on policy representation within systems and automated monitoring systems, are coming into practical use. The papers also serve to identify many of the issues which are open research questions. In particular, as management systems increase in complexity, how far can we automate the refinement of high-level policies into implementations? How can we detect and resolve conflicts between policies? And how can monitoring services deal efficiently with ever-growing complexity and volume? We wish to acknowledge the many contributors, besides the authors, who have made this issue possible: the anonymous reviewers who have done much to assure the quality of these papers, Morris Sloman and his Programme Committee who convened the Workshop, and Thomas Usländer and his team at the Fraunhofer Institute in Karlsruhe who acted as hosts.

  1. Editor's Shelf: Paperbacks.

    ERIC Educational Resources Information Center

    Mitchell-Powell, Brenda, Comp.

    1993-01-01

    Lists new paperbacks releases of work previously published in the field of multicultural education. Eighty-nine titles are listed, with titles previously reviewed marked. Editorial notes flag items that will be reviewed or that are distinguished by an award. (SLD)

  2. [From the editor].

    PubMed

    Dudek, Dominika; Sobański, Jerzy A; Klasa, Katarzyna

    2015-01-01

    Dear Readers We are happy and proud to announce that we managed to achieve intention announced in the last issue: for the first time in PubMed there is a possibility of direct and free access to the full texts published in Polish Psychiatry (Polish and English language versions are available)!!! For the issue 6/2014 they have been downloaded by Medline users already 500 times. Owing to this, papers by Polish scientists-psychiatrists are more readily available to colleagues from around the world interested in them, and Polish Psychiatry actually becomes journal of international scope. We hope that it will result in a marked improvement in the bibliometric indicators (which, however, is unrealistic to expect in the current or next year) in the following years. Spring issue of Polish Psychiatry touches several important problems. We pay attention to the texts on addiction - behavioural (Internet addiction) and alcohol. Two papers by prof. M. Wojnar's team summarize the issues related to the coexistence of alcohol dependence with other psychiatric disorders. The issue of dual diagnosis has already appeared in our magazine (for example [1]). This is an extremely difficult problem, and patients are a real challenge, both therapeutic and diagnostic. They often require a comprehensive approach: pharmacotherapy of comorbid mental illness, psychoeducation, addiction treatment programmes. For these patients the maintenance of abstinence is particularly difficult, especially in a situation of exacerbation of psychopathological symptoms. An important direction is searching for additional pharmacotherapeutic methods which help to reduce the degree of alcohol abuse and the resulting damage. These include: acamprosate, drugs which are opioid receptor antagonists [2], and in the current issue the authors from the University of Cagliari focused on baclofen. (...). PMID:26093586

  3. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1993-11-01

    First law of thermodynamics . . .Guy S M Moore36 Oakridge Avenue, Radlett, Hertfordshire WD7 8ER, UK The First law of thermodynamicsH AspdenAcres High, Hadrian Way, Chilworth, Southampton SO1 7HZ, UK Starting from basicsD G C JonesSchool of Mathematical and Physical Sciences, University of Sussex, Brighton, UK Geothermal energyJ Dunning-DaviesSchool of Mathematics, University of Hull, UK Amplitude dependence of the period for non-linear oscillatorsP GlaisterDepartment of Mathematics, University of Reading, UK The physics of a falling leafLaurence BettanyD'Youville College, 320 Porter Avenue, Buffalo, NY 14201, USA Option JGren Ireson61 Bankfield Drive, Bramcote, Nottingham NG9 3EH, UK Physics teaching in Germany: a second lookGottfried MerzynGeorg-August-Universität Göttingen, Germany Teaching relativityJames D Edmonds JrPhysics Department, McNeese State University, Lake Charles, LA 70605, USA New element discoveredNeil McKenzieDirector, Administratium Abolition Society (c/o Department of Chemistry and Physics, The Nottingham Trent University, UK)

  4. From the Editors

    NASA Astrophysics Data System (ADS)

    Pashinin, Pavel P.; Yermachenko, Valery M.; Yevseyev, Igor V.

    2010-01-01

    Dear readers and authors, This preface opens the seventh volume of the journal Laser Physics Letters. We are happy to inform you that the first six years have been quite successful for the journal. In the years 2004-2009, Laser Physics Letters published around 700 original articles written by scientists from 55 countries. During these years, in addition to original articles, Laser Physics Letters published about 40 brief review invited articles written by top scientists from different countries. These review articles provide readers a unique possibility of being timely informed on the current research in different fields of laser physics and on the most fresh and important results in these fields. The brief review articles, published in Laser Physics Letters, have attracted high attention of readers and are extensively cited. Some of these review articles have been cited more than 60 times in the main journals covered by ISI Web of Science. This shows the great importance and attractiveness of the published brief review invited articles for the laser physics community. We certainly understand that such a success is due to the following reasons. First of all, the authors of Laser Physics Letters are the top scientists in the field of laser physics from all over the world. And, second, all 28 members of the Editorial Board, representing 13 countries, are strongly committed to do all their best for making the journal an excellent forum for the laser physics community. Laser Physics Letters publishes pioneering articles in different fields of laser physics. In order to be accessible to a wide auditorium, the papers should clearly point out the main contributions of the article to the field of research and their relation to other articles treating the topic. A well-written introduction is a prerequisite for a good paper. This allows the readers to better judge on the contribution of the article and to objectively evaluate the presented results. We are proud to announce that the 2008 impact factor of Laser Physics Letters reached 3.779. This is a rather good achievement for a journal published only six years. It is important to stress that each year Laser Physics Letters publishes about 150 articles. Therefore, the high impact factor is due not to the meager amount of published papers but really to the high quality of them. It is also very important that the accepted articles are displayed on the website in the section Early View just in two weeks after their acceptance. The early-view articles are already given their publication date and DOI. It makes them immediately accessible for readers and, respectively, for citation. The procedure of refereeing the submitted manuscripts is known to be of paramount importance for any journal. The refereeing process on Laser Physics Letters is unique in two points. First, it is very fast, with the standard time of reviewing about one week after the manuscript submission. Second, the refereeing is done exclusively by the top scientists in the respective fields of laser physics. Therefore, we hope that Laser Physics Letters has produced no biased or unjustified referee reports, which are so common for many journals. The Laser Physics Letters Editorial Board expresses deep gratitude to all referees of the journal. A well-organized and qualified work of the technical department of the journal is also of great importance. We are happy that this department always guarantees the highest quality of the manuscripts camera-ready copies and their figures, which has been noticed by many authors. It is worth mentioning the close collaboration of Laser Physics Letters with the annual International Laser Physics Workshop (LPHYS). The sequel of these Workshops was launched in 1992 by the Nobel Prize winner A.M. Prokhorov. There have already been 18 of these Workshops, whose history can be traced on the website www.lasphys.com. The eighteenth Workshop was held from July 13 to July 17 in Barcelona, Spain. About 580 participants from 37 countries took part in the Workshop. We hope that the next Workshop LPH

  5. Letter to the Editor

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Elementary chemistry errors are contained in: Adsorption sequence of toxic inorganic anions on a soil by S. Saeki published in the Bulletin of Environmental Contamination and Toxicology (2008) 81:508-512. In the article, the author asserts emphatically that he is studying As(V) not As(III) adsorpt...

  6. Guest Editor's Introduction.

    ERIC Educational Resources Information Center

    Danaher, Patrick Alan

    2000-01-01

    Examines the field of international traveler and nomadic education research and argues for the need to extend the boundaries of this "field" significantly. Research on the education of travelers and nomads is mobile and fluid, but the approach used in this collection, the mapping and celebration of international diversity, is needed to expand…

  7. From the guest editors.

    PubMed

    Chowell, Gerardo; Feng, Zhilan; Song, Baojun

    2013-01-01

    Carlos Castilo-Chavez is a Regents Professor, a Joaquin Bustoz Jr. Professor of Mathematical Biology, and a Distinguished Sustainability Scientist at Arizona State University. His research program is at the interface of the mathematical and natural and social sciences with emphasis on (i) the role of dynamic social landscapes on disease dispersal; (ii) the role of environmental and social structures on the dynamics of addiction and disease evolution, and (iii) Dynamics of complex systems at the interphase of ecology, epidemiology and the social sciences. Castillo-Chavez has co-authored over two hundred publications (see goggle scholar citations) that include journal articles and edited research volumes. Specifically, he co-authored a textbook in Mathematical Biology in 2001 (second edition in 2012); a volume (with Harvey Thomas Banks) on the use of mathematical models in homeland security published in SIAM's Frontiers in Applied Mathematics Series (2003); and co-edited volumes in the Series Contemporary Mathematics entitled '' Mathematical Studies on Human Disease Dynamics: Emerging Paradigms and Challenges'' (American Mathematical Society, 2006) and Mathematical and Statistical Estimation Approaches in Epidemiology (Springer-Verlag, 2009) highlighting his interests in the applications of mathematics in emerging and re-emerging diseases. Castillo-Chavez is a member of the Santa Fe Institute's external faculty, adjunct professor at Cornell University, and contributor, as a member of the Steering Committee of the '' Committee for the Review of the Evaluation Data on the Effectiveness of NSF-Supported and Commercially Generated Mathematics Curriculum Materials,'' to a 2004 NRC report. The CBMS workshop '' Mathematical Epidemiology with Applications'' lectures delivered by C. Castillo-Chavez and F. Brauer in 2011 have been published by SIAM in 2013.

  8. From the guest editors.

    PubMed

    Chowell, Gerardo; Feng, Zhilan; Song, Baojun

    2013-01-01

    Carlos Castilo-Chavez is a Regents Professor, a Joaquin Bustoz Jr. Professor of Mathematical Biology, and a Distinguished Sustainability Scientist at Arizona State University. His research program is at the interface of the mathematical and natural and social sciences with emphasis on (i) the role of dynamic social landscapes on disease dispersal; (ii) the role of environmental and social structures on the dynamics of addiction and disease evolution, and (iii) Dynamics of complex systems at the interphase of ecology, epidemiology and the social sciences. Castillo-Chavez has co-authored over two hundred publications (see goggle scholar citations) that include journal articles and edited research volumes. Specifically, he co-authored a textbook in Mathematical Biology in 2001 (second edition in 2012); a volume (with Harvey Thomas Banks) on the use of mathematical models in homeland security published in SIAM's Frontiers in Applied Mathematics Series (2003); and co-edited volumes in the Series Contemporary Mathematics entitled '' Mathematical Studies on Human Disease Dynamics: Emerging Paradigms and Challenges'' (American Mathematical Society, 2006) and Mathematical and Statistical Estimation Approaches in Epidemiology (Springer-Verlag, 2009) highlighting his interests in the applications of mathematics in emerging and re-emerging diseases. Castillo-Chavez is a member of the Santa Fe Institute's external faculty, adjunct professor at Cornell University, and contributor, as a member of the Steering Committee of the '' Committee for the Review of the Evaluation Data on the Effectiveness of NSF-Supported and Commercially Generated Mathematics Curriculum Materials,'' to a 2004 NRC report. The CBMS workshop '' Mathematical Epidemiology with Applications'' lectures delivered by C. Castillo-Chavez and F. Brauer in 2011 have been published by SIAM in 2013. PMID:24245643

  9. From the Editors

    NASA Astrophysics Data System (ADS)

    Pashinin, Pavel P.; Yermachenko, Valery M.; Yevseyev, Igor V.

    2011-01-01

    Dear readers and authors, First of all, we would like to inform you on our main achievement over the past year: The impact factor of Laser Physics Letters reached 5.502 in 2009. This has promoted the journal to one of the leading journals in the world in the field of laser physics. We are very grateful to all friends of the journal who have sent us their congratulations with this success. Of course, we understand that this success is caused by several reasons. One of them is a high quality of papers submitted by our authors. Thanks are due to all of the authors for their contributions to this success of the journal. The second reason is the hard work of our referees who have the highest qualification, and, moreover, who are capable of providing their reports within just a few days. We acknowledge the important role of the annual International Laser Physics Workshop (LPHYS) attracting the authors for writing articles for LPL. The last, though not the least, we are very grateful to our distinguished publisher Wiley for its valuable contribution and endless efforts to make things better and, especially, to Wiley's V-P Steven Miron for his useful counsels. The location of the annual Workshop LPHYS varies each year, which makes it possible to attract scientists from different countries. In 2010, the annual international Laser Physics Workshop (LPHYS'10) was held in Brazil. Using the occasion, we stress the great work done by Prof. Bagnato for organizing this conference. In 2011, the conference LPHYS'11 will be held from July 11 to July 15 in the city of Sarajevo, Bosnia and Herzegovina, in the Congress Center of the Hotel Hollywood. We plan the participation of about 600 scientists from more than 30 countries. Concluding, we hope that Laser Physics Letters, with the help of our authors, will support and further strengthen the status of a leading journal in the field of laser physics. Sincerely Yours,

  10. [Deciphering the argots of the names of materia medica and its dosage in the Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals)].

    PubMed

    Zhou, Jian; Lin, Shiyi; Liu, Shijue

    2014-11-01

    Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals) was additionally compiled, supplemented and annotated by Zhou Sheng, a famous doctor of the Qing Dynasty, based on Yi lin kou pu (Rhymes of Medical Professionals) which was composed by Lu Qi. The book contains four volumes in total, dealing mainly with the miscellaneous diseases of internal medicine, as well as external medicine, gynecology, and pediatrics etc. The syndrome differentiation and treatment, prescriptions and medications in this book has its own characteristic with rather high academic value and practical significance. There were 20 drug names were deciphered by the argots, for instance, "you che" was the argot of golden thread, and "wu yue (May)" was the argot of medicinal evodia fruit, etc. In addition, the argots were often used to decipher numerals and quantifiers, for example, "su, qi, zi, qi, man" referring to 1, 2, 3, 4, 5 respectively, and "huo, pu, xiang, feng, lai" referring to 6, 7, 8, 9, 10 respectively, and "qing","zhong","xi" referring to qian, liang and fen respectively. Hence, deciphering of these argots could help to understand and apply these prescriptions correctly.

  11. [Deciphering the argots of the names of materia medica and its dosage in the Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals)].

    PubMed

    Zhou, Jian; Lin, Shiyi; Liu, Shijue

    2014-11-01

    Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals) was additionally compiled, supplemented and annotated by Zhou Sheng, a famous doctor of the Qing Dynasty, based on Yi lin kou pu (Rhymes of Medical Professionals) which was composed by Lu Qi. The book contains four volumes in total, dealing mainly with the miscellaneous diseases of internal medicine, as well as external medicine, gynecology, and pediatrics etc. The syndrome differentiation and treatment, prescriptions and medications in this book has its own characteristic with rather high academic value and practical significance. There were 20 drug names were deciphered by the argots, for instance, "you che" was the argot of golden thread, and "wu yue (May)" was the argot of medicinal evodia fruit, etc. In addition, the argots were often used to decipher numerals and quantifiers, for example, "su, qi, zi, qi, man" referring to 1, 2, 3, 4, 5 respectively, and "huo, pu, xiang, feng, lai" referring to 6, 7, 8, 9, 10 respectively, and "qing","zhong","xi" referring to qian, liang and fen respectively. Hence, deciphering of these argots could help to understand and apply these prescriptions correctly. PMID:25620357

  12. NASA Chandra X-ray Observatory Selected as Editor's Choice in 2000 Discover Magazine Awards for Technological Innovation

    NASA Astrophysics Data System (ADS)

    2000-06-01

    The Chandra X-ray Observatory, NASA's newest and most powerful X-ray space telescope, has been selected as the winner of the Editor's Choice category of the 2000 Discover Magazine Awards for Technological Innovation. The team of government, industry, university and research institutions that designed, built and deployed Chandra for NASA's Marshall Space Flight Center, Huntsville, Ala, will be formally recognized June 24 at a gala awards celebration at Epcot at the Walt Disney World Resort in Orlando, Fl. Dr. Harvey Tananbaum, director of the Smithsonian Astrophysical Observatory's Chandra X-ray Science Center, Cambridge, Mass., which conducts the Chandra science mission for NASA, will receive the award on behalf of the team. "Chandra has opened a new window for astronomers into the universe of high-energy cosmic events such as pulsars, supernova remnants and black holes," said Tananbaum. "We're now able to create spectacularly detailed images of celestial phenomena whose mere existence we could only hypothesize before." Among Chandra's most significant discoveries to date, he lists the detection of a giant ring around the heart of the Crab Nebula, details of the shock wave created by an exploding star and resolution of the high-energy X-ray "glow" in the universe into millions of specific light sources. "The successful launch, deployment and on-orbit operations of NASA's Chandra X-ray Observatory is a testament to the solid partnership between TRW, NASA and the science community that has been enabling NASA's most important space science missions for the past 40 years," said Timothy W. Hannemann, executive vice president and general manager, TRW Space & Electronics Group. "The extraordinary images that Chandra is delivering daily speaks loudly not only to the quality of the science instruments on board, but also to the engineering talents and dedication to mission success exhibited by every member of NASA's Chandra mission team." Chandra, named in honor of Nobel

  13. Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors.

    PubMed

    Bergman, Åke; Andersson, Anna-Maria; Becher, Georg; van den Berg, Martin; Blumberg, Bruce; Bjerregaard, Poul; Bornehag, Carl-Gustaf; Bornman, Riana; Brandt, Ingvar; Brian, Jayne V; Casey, Stephanie C; Fowler, Paul A; Frouin, Heloise; Giudice, Linda C; Iguchi, Taisen; Hass, Ulla; Jobling, Susan; Juul, Anders; Kidd, Karen A; Kortenkamp, Andreas; Lind, Monica; Martin, Olwenn V; Muir, Derek; Ochieng, Roseline; Olea, Nicolas; Norrgren, Leif; Ropstad, Erik; Ross, Peter S; Rudén, Christina; Scheringer, Martin; Skakkebaek, Niels Erik; Söder, Olle; Sonnenschein, Carlos; Soto, Ana; Swan, Shanna; Toppari, Jorma; Tyler, Charles R; Vandenberg, Laura N; Vinggaard, Anne Marie; Wiberg, Karin; Zoeller, R Thomas

    2013-08-27

    The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.

  14. Personalized Medicine Across Disciplines and without Borders. Vural Özdemir speaks to Hannah Wilson, Commissioning Editor

    PubMed Central

    Özdemir, Vural

    2015-01-01

    . He is also a Visiting Professor (Global Health & Technology Foresight) at Amrita University in Kerala, India, and cofounder of the Data-Enabled Life Sciences Alliance (DELSA Global), an open innovation and knowledge translation platform in Seattle (WA, USA). Özdemir was named as coinventor of 12 World Intellectual Property Organization (WIPO) indexed patents in personalized medicine and has authored more than 130 peer reviewed articles and chapters on the translation of omics technologies into public health action, global technology governance, diagnostics innovation strategy, history of bioethics and the ethics-of-bioethics. ‘Science Peace Corps’ and ‘Microgrants for Big Data’ are two new knowledge translation and science communication concepts developed by Özdemir for the global governance of biotechnology. He is Editor-in-Chief of OMICS: A Journal of Integrative Biology, published by Mary Ann Liebert, Inc. (NY, USA). PMID:26120345

  15. Systems analysis programs for hands-on integrated reliability evaluations (SAPHIRE) Version 5.0. Fault tree, event tree, and piping & instrumentation diagram (FEP) editors reference manual: Volume 7

    SciTech Connect

    McKay, M.K.; Skinner, N.L.; Wood, S.T.

    1994-07-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) refers to a set of several microcomputer programs that were developed to create and analyze probabilistic risk assessments (PRAs), primarily for nuclear power plants. The Fault Tree, Event Tree, and Piping and Instrumentation Diagram (FEP) editors allow the user to graphically build and edit fault trees, and event trees, and piping and instrumentation diagrams (P and IDs). The software is designed to enable the independent use of the graphical-based editors found in the Integrated Reliability and Risk Assessment System (IRRAS). FEP is comprised of three separate editors (Fault Tree, Event Tree, and Piping and Instrumentation Diagram) and a utility module. This reference manual provides a screen-by-screen guide of the entire FEP System.

  16. Guest Editor's introduction: Selected papers from the 4th USENIX Conference on Object-Oriented Technologies and Systems

    NASA Astrophysics Data System (ADS)

    Sventek, Joe

    1998-12-01

    -of-Service (QoS) features in distributed, object-oriented systems. They present a general QoS language, QML, that can be used to capture QoS properties as part of a design. They also show how to extend UML to support QML concepts. The paper by Szymaszek, Uszok and Zielinski discusses the important issue of efficient implementation and usage of fine-grained objects in CORBA-based applications. Fine-grained objects can have serious ramifications on overall application performance and scalability, and the paper suggests that such objects should not be treated as first-class CORBA objects, proposing instead the use of collections and smart proxies for efficient implementation. The paper by Milojicic, LaForge and Chauhan describes a mobile objects and agents infrastructure. Their particular research has focused on communication support across agent migration and extensive resource control. The paper also discusses issues regarding interoperation between agent systems. Acknowledgments The editor wishes to thank all of the authors, reviewers and publishers. Without their excellent work, and the contribution of their valuable time, this special issue would not have been possible.

  17. Letter to the Editor in response to "publication performance of women compared to men in German cardiology" by Boehm et al. (2014).

    PubMed

    Weismann, Constance G; Colson, Eve R; Shapiro, Eugene D

    2015-03-01

    Based on their review of abstracts submitted to the German Cardiac Society, Boehm et al. (2014) report better success of female vs male cardiologists publishing in journals with an impact factor ≥5. However, only 25% of conference abstracts were submitted by women, perhaps suggesting a paucity of women in academic cardiology. In this 'letter to the editor' we review gender statistics in the medical field using Germany and the US as examples. While women are well represented in early career stages, only fewfull professors are women. This reflects a wasted opportunity to benefit from the best of both genders. Recent gender research has shown that subtle gender bias may play a role. To change the gender statistics in academic medicine a multifaceted approach is necessary. This will ultimately lead to a more equal representation of women in senior roles, and bring science, medical care, and leadership to a new level.

  18. Letter to the Editor in response to "publication performance of women compared to men in German cardiology" by Boehm et al. (2014).

    PubMed

    Weismann, Constance G; Colson, Eve R; Shapiro, Eugene D

    2015-03-01

    Based on their review of abstracts submitted to the German Cardiac Society, Boehm et al. (2014) report better success of female vs male cardiologists publishing in journals with an impact factor ≥5. However, only 25% of conference abstracts were submitted by women, perhaps suggesting a paucity of women in academic cardiology. In this 'letter to the editor' we review gender statistics in the medical field using Germany and the US as examples. While women are well represented in early career stages, only fewfull professors are women. This reflects a wasted opportunity to benefit from the best of both genders. Recent gender research has shown that subtle gender bias may play a role. To change the gender statistics in academic medicine a multifaceted approach is necessary. This will ultimately lead to a more equal representation of women in senior roles, and bring science, medical care, and leadership to a new level. PMID:25617604

  19. A Study of How Letters to the Editor Published in "The Stars and Stripes" Newspaper between March 1, 1918, and November 15, 1918, Reflected the Morale of the Troops during World War I

    ERIC Educational Resources Information Center

    Hatch, Vicky Ann

    2009-01-01

    This dissertation is a qualitative historical study that examines the state of morale of World War I soldiers as reflected in letters to the editor published in "The Stars and Stripes" newspaper between March 1, 1918, and November 15, 1918. The narrative includes extensive use of the actual words published in the soldiers' letters in order to…

  20. In memoriam: Janis Huston Audin, MSc, DVM, 1950-2009. Dynamic editor-in-chief of the Journal of the American Veterinary Medical Association and strong One Health advocate dies.

    PubMed

    Kaplan, Bruce

    2009-01-01

    Dr Janis H. Audin (MSc Illinois 1975, DVM Illinois 1979), a champion of progressive veterinary medical journalism and 'One Health' died on 22 April 2009 following a long, courageous and difficult battle with pancreatic cancer. The world has lost a truly significant One Health leader and advocate. Under her guidance, the Journal of the American Veterinary Medical Association (JAVMA) implemented a 'one-health wonders' column that recognised and highlighted prominent One Health individuals among the medical and veterinary medical professions in the United States. The American Veterinary Medical Association (AVMA) has lost a dedicated and gifted editor-in-chief. Dr Audin joined the editorial staff of the AVMA in 1985, as an assistant editor and was promoted to associate editor in 1989 and editor in 1994. She became the editor-in-chief of both the JAVMA and the American Journal of Veterinary Research in 1995. Prior to that, Dr Audin practised as an associate veterinarian in Calumet City, Illinois, for four years. During her tenure, Dr Audin was noted for implementing procedural and technological changes in the journal to reduce costs, improve timeliness of publications and promote readership interest and awareness. New features in the News section introduced under her leadership have made the journals more practical and public health-relevant. For instance, Dr Audin fostered the United States Department of Agriculture's Food Safety and Inspection Service (USDA-FSIS) 'Inspection Insights' - a public health-oriented food safety monthly column related to meat, poultry and egg products - from 1996 through 1998. She also increased international manuscript submissions. On 23 March 2009 AVMA Executive Vice President Dr W. Ron DeHaven named Dr Audin as editor-in-chief emeritus of the Publications Division. Wisely, it also meant that Dr Audin could continue contributing to the staff effort to ensure the high quality of the AVMA scientific journals while the Association began a

  1. Characterization of two urostylid ciliates, Metaurostylopsis flavicana spec. nov. and Tunicothrix wilberti (Lin & Song, 2004) Xu et al., 2006 (Ciliophora, Stichotrichia), from a mangrove nature protection area in China.

    PubMed

    Wang, Yangang; Hu, Xiaozhong; Huang, Jie; Al-Rasheid, Khaled A S; Warren, Alan

    2011-07-01

    Two marine stichotrich ciliates, Metaurostylopsis flavicana spec. nov. and Tunicothrix wilberti (Lin & Song, 2004) Xu et al., 2006, isolated from the Shenzhen Mangrove Protection Area on the coast of the South China Sea, were investigated using live observation and protargol impregnation techniques. Metaurostylopsis flavicana is characterized by its elongate body shape, yellowish body colour and bright-yellow cortical granules that are either grouped around the cirri and the dorsal cilia or aligned between the rows of cirri and dorsal cilia. It has four to eight frontal, two frontoterminal, one buccal and seven to ten transverse cirri, a mid-ventral complex comprising 13-17 midventral cirral pairs in a row that extends about three-fifths of the body length, four left and three right marginal rows and three complete dorsal kineties. The small subunit rRNA gene of this species was sequenced and phylogenetic trees were constructed in which M. flavicana does not group with its congeners, suggesting that the genus Metaurostylopsis is paraphyletic. Some supplementary morphological and morphogenetic traits for Tunicothrix wilberti are also documented.

  2. Martin Gibbs (1922-2006): Pioneer of (14)C research, sugar metabolism & photosynthesis; vigilant Editor-in-Chief of Plant Physiology; sage Educator; and humanistic Mentor.

    PubMed

    Black, Clanton C

    2008-01-01

    The very personal touch of Professor Martin Gibbs as a worldwide advocate for photosynthesis and plant physiology was lost with his death in July 2006. Widely known for his engaging humorous personality and his humanitarian lifestyle, Martin Gibbs excelled as a strong international science diplomat; like a personal science family patriarch encouraging science and plant scientists around the world. Immediately after World War II he was a pioneer at the Brookhaven National Laboratory in the use of (14)C to elucidate carbon flow in metabolism and particularly carbon pathways in photosynthesis. His leadership on carbon metabolism and photosynthesis extended for four decades of working in collaboration with a host of students and colleagues. In 1962, he was selected as the Editor-in-Chief of Plant Physiology. That appointment initiated 3 decades of strong directional influences by Gibbs on plant research and photosynthesis. Plant Physiology became and remains a premier source of new knowledge about the vital and primary roles of plants in earth's environmental history and the energetics of our green-blue planet. His leadership and charismatic humanitarian character became the quintessence of excellence worldwide. Martin Gibbs was in every sense the personification of a model mentor not only for scientists but also shown in devotion to family. Here we pay tribute and honor to an exemplary humanistic mentor, Martin Gibbs.

  3. Letter to the editor concerning the article "Performance of gymnastics skill benefits from an external focus of attention" by Abdollahipour, Wulf, Psotta & Nieto (2015).

    PubMed

    Collins, Dave; Carson, Howie J; Toner, John

    2016-01-01

    Abdollahipour, Wulf, Psotta, and Nieto (2015) recently published data in the Journal of Sports Sciences to show that an external focus of attention promotes superior performance effects (gymnastics jump height and judged movement form score) when compared to internal or control foci during skill execution without an implement involved. While we do not contest the veracity of findings reported, nor others that have been used to support beneficial effects of an external focus of attention, in this Letter to the Editor we comment on considerable methodological limitations associated with this and previous studies that, we suggest, have resulted in serious theoretical oversights regarding the control of movement and, most crucially from our practitioner perspective, suboptimal recommendations for applied coaching practice. Specifically, we discuss the lack of consideration towards translational research in this area, the problematic nature of attentional focus cues employed, interpretation of findings in relation to other applied recommendations and coherence with mechanistic underpinning and, finally, the representative nature of task involved. In summary, while (laboratory) research evidence may appear to be conclusive, we suggest that the focus of attention effects are in need of more ecologically valid and rigorous testing as well as consideration of current coaching practices if it is to optimally serve the applied sporting domain that it purportedly aims to. PMID:26824823

  4. Big-Bang-Gate Cosmic Titanic: Why Aren't Physics Journal's Editors Bringing It To The Center of Scientific Attention

    NASA Astrophysics Data System (ADS)

    Gentry, Robert

    2010-02-01

    Until now science's greatest debacle occurred when Copernicus exposed Ptolemaic cosmologists' 1300 hundred year-long fraud that it must be true because observations fit theory so well, while they ignored the untested state of its central assumption of Earth centered planetary motion. With much hubris modern physicists are confident this could never happen again, that the integrity of physics journals editors suffices to guarantee that a challenge to the reigning cosmological theory -- big bang cosmology -- would immediately be brought to the center of scientific attention for analysis and discussion. In fact a decade ago it was reported [MPLA 2619 (1997); arXiv:gr-gc/9806061] that, like Ptolemaic cosmology before it, big bang's central assumption that GR expansion effects cause in-flight expansion had never been tested and, further, that experimental testing of it using GR operation of the GPS showed it to be false. This result proves it is impossible for the 2.73 K CBR to be fireball relic radiation. These results were expanded in CERN reports EXT-2003-021;022, but have been uniformly rejected by physics journals, one of which accepted a paper similar to CERN EXT-2003-022, only to reject it a few days later with the admission not to publish it because of fearing reaction of the worldwide physics community. For update on my PRL submission see http://www.alphacosmos.net. )

  5. Authors' response to the letter to the editor: "Effects of acoustic feedback training in elite-standard Para-Rowing" by Schaffert and Mattes (2015).

    PubMed

    Schaffert, Nina; Mattes, Klaus

    2015-01-01

    Our article in the Journal of Sports Sciences was designed to examine effects of auditory feedback on mean boat speed during on-water training of visually impaired athletes in elite-standard Para-Rowing. This aim is stated explicitly in the title, abstract, introduction and discussion section. The effects were analysed on the basis of a conservative approach to using inferential statistics by emphasising measures that communicate meaningful differences and effect sizes to help interpret the data's practical importance for sport competition. Biomechanical measurements have been combined with standardised questionnaires to assess the athletes' perceived experience during rowing with acoustic feedback. An application for high-performance rowing has already been used to successfully investigate the effects of acoustic feedback on the time structure of the rowing cycle during the recovery phase. In this response, we provide our comments to the concerns presented in the 'Letter to the Editor' along with a brief description of the issues that relate to research in high-performance sport. PMID:25599408

  6. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors' Expert Forum.

    PubMed

    Cefalu, William T; Buse, John B; Tuomilehto, Jaakko; Fleming, G Alexander; Ferrannini, Ele; Gerstein, Hertzel C; Bennett, Peter H; Ramachandran, Ambady; Raz, Itamar; Rosenstock, Julio; Kahn, Steven E

    2016-07-01

    The International Diabetes Federation estimates that 415 million adults worldwide now have diabetes and 318 million have impaired glucose tolerance. These numbers are expected to increase to 642 million and 482 million, respectively, by 2040. This burgeoning pandemic places an enormous burden on countries worldwide, particularly resource-poor regions. Numerous landmark trials evaluating both intensive lifestyle modification and pharmacological interventions have persuasively demonstrated that type 2 diabetes can be prevented or its onset can be delayed in high-risk individuals with impaired glucose tolerance. However, key challenges remain, including how to scale up such approaches for widespread translation and implementation, how to select appropriately from various interventions and tailor them for different populations and settings, and how to ensure that preventive interventions yield clinically meaningful, cost-effective outcomes. In June 2015, a Diabetes Care Editors' Expert Forum convened to discuss these issues. This article, an outgrowth of the forum, begins with a summary of seminal prevention trials, followed by a discussion of considerations for selecting appropriate populations for intervention and the clinical implications of the various diagnostic criteria for prediabetes. The authors outline knowledge gaps in need of elucidation and explore a possible new avenue for securing regulatory approval of a prevention-related indication for metformin, as well as specific considerations for future pharmacological interventions to delay the onset of type 2 diabetes. They conclude with descriptions of some innovative, pragmatic translational initiatives already under way around the world. PMID:27631469

  7. Martin Gibbs (1922-2006): Pioneer of (14)C research, sugar metabolism & photosynthesis; vigilant Editor-in-Chief of Plant Physiology; sage Educator; and humanistic Mentor.

    PubMed

    Black, Clanton C

    2008-01-01

    The very personal touch of Professor Martin Gibbs as a worldwide advocate for photosynthesis and plant physiology was lost with his death in July 2006. Widely known for his engaging humorous personality and his humanitarian lifestyle, Martin Gibbs excelled as a strong international science diplomat; like a personal science family patriarch encouraging science and plant scientists around the world. Immediately after World War II he was a pioneer at the Brookhaven National Laboratory in the use of (14)C to elucidate carbon flow in metabolism and particularly carbon pathways in photosynthesis. His leadership on carbon metabolism and photosynthesis extended for four decades of working in collaboration with a host of students and colleagues. In 1962, he was selected as the Editor-in-Chief of Plant Physiology. That appointment initiated 3 decades of strong directional influences by Gibbs on plant research and photosynthesis. Plant Physiology became and remains a premier source of new knowledge about the vital and primary roles of plants in earth's environmental history and the energetics of our green-blue planet. His leadership and charismatic humanitarian character became the quintessence of excellence worldwide. Martin Gibbs was in every sense the personification of a model mentor not only for scientists but also shown in devotion to family. Here we pay tribute and honor to an exemplary humanistic mentor, Martin Gibbs. PMID:17828443

  8. Letter to the editor concerning the article "Performance of gymnastics skill benefits from an external focus of attention" by Abdollahipour, Wulf, Psotta & Nieto (2015).

    PubMed

    Collins, Dave; Carson, Howie J; Toner, John

    2016-01-01

    Abdollahipour, Wulf, Psotta, and Nieto (2015) recently published data in the Journal of Sports Sciences to show that an external focus of attention promotes superior performance effects (gymnastics jump height and judged movement form score) when compared to internal or control foci during skill execution without an implement involved. While we do not contest the veracity of findings reported, nor others that have been used to support beneficial effects of an external focus of attention, in this Letter to the Editor we comment on considerable methodological limitations associated with this and previous studies that, we suggest, have resulted in serious theoretical oversights regarding the control of movement and, most crucially from our practitioner perspective, suboptimal recommendations for applied coaching practice. Specifically, we discuss the lack of consideration towards translational research in this area, the problematic nature of attentional focus cues employed, interpretation of findings in relation to other applied recommendations and coherence with mechanistic underpinning and, finally, the representative nature of task involved. In summary, while (laboratory) research evidence may appear to be conclusive, we suggest that the focus of attention effects are in need of more ecologically valid and rigorous testing as well as consideration of current coaching practices if it is to optimally serve the applied sporting domain that it purportedly aims to.

  9. The 5/95 Gap on the dissemination of mental health research: The World Psychiatric Association (WPA) task force report on project with editors of low and middle income (LAMI) countries.

    PubMed

    de Jesus Mari, J; Patel, V; Kieling, C; Anders, M; Jakovljevi, M; Lam, L C; Lotaief, F; Mendlowicz, M V; Okulat, G; Sathyanarayana Rao, T S; Tamam, L; Tyrer, P; Herrman, H

    2009-02-01

    The World Psychiatric Association (WPA) Task Force and a small group previously convened by the WPA publications committee initiated three activities between 2006-2008 that aimed to respond to the need for greater support for psychiatry journals in LAMI countries. In a joint venture with participants from the Global Mental Health Movement the Task Force editors from LAMI countries in Africa, Asia, Eastern Europe and Latin America were contacted to identify potential journals to target for indexation (Medline and ISI). The committee analyzed the editors' applications on the following criteria: a) geographical representativeness; b) affiliation to a professional mental health society; c) regular publication of at least 4 issues per year over the past few years; d) comprehensive national and international editorial boards; e) publication of original articles, or at least abstracts, in English; f) some level of current indexation; g) evidence of a good balance between original and review articles in publications; and h) a friendly access website. The committee received 26 applications (11 from Latin America, 7 from Central Europe, 4 from Asia and 4 from Africa), and selected 8 journals, 2 from each geographical area, on the basis of the overall scores obtained for the items mentioned, to participate in an editors meeting held in Prague in September 2008. The aims of the committee are twofold: a) to concentrate support for those selected journals; and b) to assist all LAMI mental health editors in improving the quality of their journals and fulfilling the requirements for full indexation. This report summarizes the procedures conducted by the committee, the assessment of the current non-indexed journals, and offers suggestions for further action.

  10. Antecedents to agenda setting and framing in health news: an examination of priority, angle, source, and resource usage from a national survey of U.S. health reporters and editors.

    PubMed

    Wallington, Sherrie Flynt; Blake, Kelly; Taylor-Clark, Kalahn; Viswanath, K

    2010-01-01

    The influence of news media on audience cognitions, attitudes, and behaviors in the realm of politics, race relations, science, and health has been extensively documented.Agenda setting and framing studies show that news media influence how people develop schema and place priorities on issues, with media stories serving as a major source of issue frames. Although news media are an important intermediary in the translation of scientific knowledge to different publics, little has been documented about the production of health news and factors that may predict media agenda setting and framing in health journalism. We used data from a 2005 national survey of U.S. health reporters and editors to examine predictors of source, resource, story angle, and frame usage among reporters and editors by variables such as organizational structure, individual characteristics of respondents (such as education and years working as a journalist),and perceptions of occupational autonomy. Multivariable logistic regression models revealed several differences among U.S. health reports and editors in the likelihood of using a variety of news sources, resources, priorities, and angles in reporting. Media agenda setting and framing theories suggest that practitioners familiar with media processes can work with journalists to frame messages, thereby increasing the probability of accurate and effective reporting. Results from this study may help to inform interactions between public health and medical practitioners and the press [corrected]. PMID:20390978

  11. Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.

    PubMed

    Leroux, Louis-Philippe; Nishi, Manami; El-Hage, Sandy; Fox, Barbara A; Bzik, David J; Dzierszinski, Florence S

    2015-10-01

    Toxoplasma gondii is an obligate intracellular protozoan parasite. This apicomplexan is the causative agent of toxoplasmosis, a leading cause of central nervous system disease in AIDS. It has long been known that T. gondii interferes with major histocompatibility complex class II (MHC-II) antigen presentation to attenuate CD4(+) T cell responses and establish persisting infections. Transcriptional downregulation of MHC-II genes by T. gondii was previously established, but the precise mechanisms inhibiting MHC-II function are currently unknown. Here, we show that, in addition to transcriptional regulation of MHC-II, the parasite modulates the expression of key components of the MHC-II antigen presentation pathway, namely, the MHC-II-associated invariant chain (Ii or CD74) and the peptide editor H2-DM, in professional antigen-presenting cells (pAPCs). Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II in vitro. CD74 mRNA and protein levels were, surprisingly, elevated in infected cells, whereas MHC-II and H2-DM expression was inhibited. CD74 accumulated mainly in the endoplasmic reticulum (ER), and this phenotype required live parasites, but not active replication. Finally, we compared the impacts of genetic deletion of CD74 and H2-DM genes on parasite dissemination toward lymphoid organs in mice, as well as activation of CD4(+) T cells and interferon gamma (IFN-γ) levels during acute infection. Cyst burdens and survival during the chronic phase of infection were also evaluated in wild-type and knockout mice. These results highlight the fact that the infection is influenced by multiple levels of parasite manipulation of the MHC-II antigen presentation pathway. PMID:26195549

  12. A Visually Oriented Text Editor

    NASA Technical Reports Server (NTRS)

    Gomez, J. E.

    1985-01-01

    HERMAN employs Evans & Sutherland Picture System 2 to provide screenoriented editing capability for DEC PDP-11 series computer. Text altered by visual indication of characters changed. Group of HERMAN commands provides for higher level operations. HERMAN provides special features for editing FORTRAN source programs.

  13. Intelligent editor/printer enhancements

    NASA Technical Reports Server (NTRS)

    Woodfill, M. C.; Pheanis, D. C.

    1983-01-01

    Microprocessor support hardware, software, and cross assemblers relating to the Motorola 6800 and 6809 process systems were developed. Pinter controller and intelligent CRT development are discussed. The user's manual, design specifications for the MC6809 version of the intelligent printer controller card, and a 132-character by 64-line intelligent CRT display system using a Motorola 6809 MPU, and a one-line assembler and disassembler are provided.

  14. Editor's Shelf: International Juvenile Titles.

    ERIC Educational Resources Information Center

    Mitchell-Powell, Brenda

    1994-01-01

    Provides an annotated list of international juvenile picture books and notes those that emphasize text over pictures. The 49 titles present international perspectives for educators, librarians, and parents seeking materials with alternative cultural content. The majority are folk tales. (SLD)

  15. Editorial - Energy & Fuels editor search.

    SciTech Connect

    Winans, R. E.; Chemistry

    2001-05-01

    The catalytic activity and selectivity for hydrodesulfurization (HDS) and olefin hydrogenation of FCC naphtha have been determined for MoS2 (no Co) catalysts on different supports and for a commercial CoMo/alumina HDS catalyst both with and without the addition of alkali. For MoS2 catalysts, the specific HDS activity is higher on silica than alumina, while addition of Cs resulted in no change in the activity. The differences in activity, however, are relatively small, a factor of less than two. EXAFS and XRD structural analysis indicate that small MoS2 particles are present on all catalysts. The differences in rate are not due to differences in particle size, dispersion, or support physical properties, but are likely due to the modification of catalytic properties by an interaction with the support. While there is a small influence on the rate, the composition of the support, or modification by Cs, has no effect on the HDSlolefin hydrogenation selectivity. The olefin hydrogenation conversion increases linearly with HDS conversion, and at high HDS conversion, few olefins remain in the FCC naphtha. Similar to the effect for Cs promotion of MoS2 on alumina, the addition of K to sulfided CoMo/alumina had little affect on the activity or selectivity for HDS and olefin hydrogenation. Unlike MoS2 catalysts, however, with sulfided CoMo at less than about 85% HDS conversion, the rate of olefin hydrogenation is low, but it increases rapidly as the sulfur in the naphtha drops below about 300 ppm. Selective HDS of FCC naphtha appears to correlate primarily to the formation of the CoMoS phase, rather than to the basic nature of the support. It is proposed that the enhanced olefin hydrogenation selectivity of CoMo catalysts is due to the competitive adsorption of sulfur compounds, which inhibit adsorption and saturation of olefins in the naphtha.

  16. Notes from the guest editor.

    PubMed

    Dewa, Carolyn S

    2011-01-01

    In 2009, four institutes of the Canadian Institutes of Health Research (Gender and Health; Health Services and Policy Research; Neurosciences, Mental Health and Addiction; and Population and Public Health) sponsored the Fourth Annual Canadian Research Congress on Mental Health and Addictions in the Workplace, in Toronto, Ontario. Hosted by the Work and Well-Being Research and Evaluation Program at the Centre for Addiction and Mental Health, the theme of the congress was We Can Do It! Evidence and Interventions for Transforming Mental Health in the Workplace (see http://www.kewa.camh.net/researchers/areas/work_wellbeing/Pages/default.aspx for more details). Coincidentally, in the same year, an idealistic presidential hopeful named Barack Obama adopted a similar slogan for his White House run. Obama recognized that change that challenges established barriers can only come about through co-operation and a collective investment. PMID:24917252

  17. [Interview with the editor-in-chief of Nature--a decade for psychiatrie disorders. Interview by Shinsuke Koike, Atsushi Nishida, Syudo Yamasaki and Shuntaro Ando].

    PubMed

    Campbell, Philip

    2012-01-01

    Nature is the most frequently cited interdisciplinary science journal globally; however, it has recently begun publishing impressive reviews and special topics in the fields of mental health and psychiatric disorders. An editorial entitled, "A decade for psychiatric disorders" was published on the first page of the first 2010 issue of Nature. This editorial was a significantly symbolic publication; not only did it have an impressive title, but also consisted of precise and appropriate content in accordance with the present conditions and future perspectives of psychiatric disorders. This was of further significance as it was published on the first page of the first 2010 issue. In this report, we review an interview with the author of the editorial and the editor-in-chief of Nature, Dr. Philip Campbell. He explained to us the reason for Nature increasingly publishing articles in the fields of mental health and psychiatric disorders, and the reason for this editorial being published in this impressive space. He opined that, although the pathophysiology of psychiatric disorders has been gradually revealed through scientific progress in most research fields, a big gap remains between cancer and psychiatric disorders with regard to health policy and research conditions. The entire editorial team of Nature believed that they could contribute in some way to bridge this gap. He was of the opinion that the media should be apprised with appropriate information on psychiatric disorders by mental health researchers in order to dispel the stigma associated with these disorders and create awareness of the importance of mental health among the public. He drew our attention to the recent brilliant progress in neuroscience research and the future perspectives of mental health research; this trend was notably observed in recent articles in Nature. The concluding sentence in "A decade for psychiatric disorders" is, "Yet the exposure of many psychiatrists to contemporary biology is

  18. Plant Type Selection for Reclamation of Sarcheshmeh Copper Mine Using Fuzzy-Topsis Approach / Wybór Gatunków Roślin Do Wykorzystania W Projekcie Rekultywacji Terenów Kopalni Miedzi Sarcheshmeh Z Wykorzystaniem Metod Logiki Rozmytej Topsis

    NASA Astrophysics Data System (ADS)

    Ebrahimabadi, Arash; Alavi, Iraj

    2013-09-01

    Plant species selection is a multi-criteria evaluation decision and has a strategic importance for many companies. The conventional methods for plant species selection are inadequate for dealing with the imprecise or vague nature of linguistic assessment. To overcome this difficulty, fuzzy multi-criteria decision-making methods are proposed. The aim of this study is to use the fuzzy technique for order preference by similarity to ideal solution (F.TOPSIS) methods for the selection of plant species in mine reclamation plan. Plant type selection and planting to protect the environment and the reclamation of the mine are some of the most important solutions. Therefore, the objective of the current research study is to choose the proper plant types for reclamation of Sarcheshmeh Copper Mine using Fuzzy-topsis method. In this regard, primarily, surrounding area of Sarcheshmeh copper mine, one of the world's 10 biggest copper mine which is located near Kerman city of Iran, are surveyed, to choose the best plant type for reclamation of disturbance area. With this respect, based on reclamation plan, primary criteria were consisted of kinds of post mining land use, climate, and nature of soil. Comparison matrixes were then obtained based on experts' opinion and plant types were subsequently prioritized using the Fuzzy Topsis method. Secondary factors considered through the analysis were as follows: perspective of the region, resistance against disease and insects, strength and method of growth, availability to plant type, economic efficiency, protection of soil, storing water, and prevention of pollution. Finally, suitable plant types in the mining perimeter were prioritized as: Amygdalus scoparia, Tamarix, Pistachio Wild, Ephedra, Astragalus, Salsola, respectively. Wybór gatunków roślin jest decyzją podejmowaną w oparciu o wiele kryteriów i stanowi poważne wyzwanie strategiczne dla wielu firm. Konwencjonalne metody wyboru gatunków roślin okazują si

  19. Transient Non Lin Deformation in Fractured Rock

    1998-10-14

    MATLOC is a nonlinear, transient, two-dimensional (planer and axisymmetric), thermal stress, finite-element code designed to determine the deformation within a fractured rock mass. The mass is modeled as a nonlinear anistropic elastic material which can exhibit stress-dependent bi-linear locking behavior.

  20. Letter to the Editor: Appropriate selection of dose coefficients in radiological assessments: C-14 and Cl-36: response to the letter of G Smith and M Thorne (2015 J. Radiol. Prot. 35 737-40)

    SciTech Connect

    Harrison, John D.; Leggett, Richard Wayne

    2016-01-01

    This letter to the editor of Journal of Radiological Protection is in response to a letter to the editor from G. M. Smith and M. C. Thorne of Great Britain concerning the appropriate selection of dose coefficients for ingested carbon-14 and chlorine-36, two of the most important long-lived components of radioactive wastes. Smith and Thorne argue that current biokinetic models of the International Commission on Radiological Protection (ICRP) for carbon and chlorine are overly cautious models from the standpoint of radiation dose estimates for C-14 and Cl-36, and that more realistic models are needed for evaluation of the hazards of these radionuclides in nuclear wastes. We (Harrison and Leggett) point out that new biokinetic models for these and other elements (developed at ORNL) will soon appear in ICRP Publications. These new models generally are considerably more realistic than current ICRP models. Here, examples are given for C-14 inhaled as carbon dioxide or ingested in water as bicarbonate, carbonate, or carbon dioxide.