Interventions for preventing injuries caused by impaired alertness in individuals with jet lag and shift work disorder

PubMed Central

Ker, Katharine; Edwards, Philip James; Roberts, Ian; Blackhall, Karen; Felix, Lambert M

2014-01-01

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of interventions for preventing injuries caused by impaired alertness in persons with jet lag or shift work disorder. PMID:25267894

Nutritional strategies for football: counteracting heat, cold, high altitude, and jet lag.

PubMed

Armstrong, Lawrence E

2006-07-01

Environmental factors often influence the physical and mental performance of football players. Heat, cold, high altitude, and travel across time zones (i.e. leading to jet lag) act as stressors that alter normal physiological function, homeostasis, metabolism, and whole-body nutrient balance. Rather than accepting performance decrements as inevitable, well-informed coaches and players should plan strategies for training and competition that offset environmental challenges. Considering the strength of scientific evidence, this paper reviews recommendations regarding nutritional interventions that purportedly counterbalance dehydration, hyperthermia, hypothermia, hypoxia, acute or chronic substrate deficiencies, sleep loss, and desynchronization of internal biological clocks.

Social jet-lag potentiates obesity and metabolic syndrome when combined with cafeteria diet in rats.

PubMed

Espitia-Bautista, Estefania; Velasco-Ramos, Mario; Osnaya-Ramírez, Iván; Ángeles-Castellanos, Manuel; Buijs, Ruud M; Escobar, Carolina

2017-07-01

Modern lifestyle promotes shifted sleep onset and shifted wake up time between weekdays and weekends, producing a condition termed "social-jet lag." Disrupted sleep promotes increased appetite for carbohydrate and fat-rich food, which in long term leads to overweight, obesity and metabolic syndrome. In order to mimic the human situation we produced an experimental model of social-jet lag (Sj-l). With this model, we explored the link between shifted sleep time with consumption of a cafeteria diet (CafD) and the development of obesity and metabolic syndrome. The first experiment was designed to create and confirm the model of Sj-l. Rats (n=8-10/group) were exposed to a shifted sleep time protocol achieved by placing the rats in slow rotating wheels from Monday to Friday during the first 4h of the light period, while on weekends they were left undisturbed. The second experiment (n=8-12/group) explored the combined effect of Sj-l with the opportunity to ingest CafD. All protocols lasted 12weeks. We evaluated the development of overweight and indicators of metabolic syndrome. The statistical significance for all variables was set at P<0.05. Sj-l alone did not affect body weight gain but induced significant changes in cholesterol in metabolic variables representing a risk factor for metabolic syndrome. Daily restricted access to CafD in the day or night induced glucose intolerance and only CafD during the day led to overweight. Sj-l combined with CafD induced overconsumption of the diet, potentiated body weight gain (16%) and promoted 5 of the criteria for metabolic syndrome including high insulin and dislipidemia. Present data provide an experimental model of social-jet lag that combined with overconsumption of CafD, and maximized the development of obesity and metabolic syndrome. Importantly, access to CafD during the night did not lead to overweight nor metabolic syndrome. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of northbound long-haul international air travel on sleep quantity and subjective jet lag and wellness in professional Australian soccer players.

PubMed

Fowler, Peter; Duffield, Rob; Howle, Kieran; Waterson, Adam; Vaile, Joanna

2015-07-01

The current study examined the effects of 10-h northbound air travel across 1 time zone on sleep quantity, together with subjective jet lag and wellness ratings, in 16 male professional Australian football (soccer) players. Player wellness was measured throughout the week before (home training week) and the week of (away travel week) travel from Australia to Japan for a preseason tour. Sleep quantity and subjective jet lag were measured 2 d before (Pre 1 and 2), the day of, and for 5 d after travel (Post 1-5). Sleep duration was significantly reduced during the night before travel (Pre 1; 4.9 [4.2-5.6] h) and night of competition (Post 2; 4.2 [3.7-4.7] h) compared with every other night (P<.01, d>0.90). Moreover, compared with the day before travel, subjective jet lag was significantly greater for the 5 d after travel (P<.05, d>0.90), and player wellness was significantly lower 1 d post-match (Post 3) than at all other time points (P<.05, d>0.90). Results from the current study suggest that sleep disruption, as a result of an early travel departure time (8 PM) and evening match (7:30 PM), and fatigue induced by competition had a greater effect on wellness ratings than long-haul air travel with a minimal time-zone change. Furthermore, subjective jet lag may have been misinterpreted as fatigue from sleep disruption and competition, especially by the less experienced players. Therefore, northbound air travel across 1 time zone from Australia to Asia appears to have negligible effects on player preparedness for subsequent training and competition.

Modelling blazar flaring using a time-dependent fluid jet emission model - an explanation for orphan flares and radio lags

NASA Astrophysics Data System (ADS)

Potter, William J.

2018-01-01

Blazar jets are renowned for their rapid violent variability and multiwavelength flares, however, the physical processes responsible for these flares are not well understood. In this paper, we develop a time-dependent inhomogeneous fluid jet emission model for blazars. We model optically thick radio flares for the first time and show that they are delayed with respect to the prompt optically thin emission by ∼months to decades, with a lag that increases with the jet power and observed wavelength. This lag is caused by a combination of the travel time of the flaring plasma to the optically thin radio emitting sections of the jet and the slow rise time of the radio flare. We predict two types of flares: symmetric flares - with the same rise and decay time, which occur for flares whose duration is shorter than both the radiative lifetime and the geometric path-length delay time-scale; extended flares - whose luminosity tracks the power of particle acceleration in the flare, which occur for flares with a duration longer than both the radiative lifetime and geometric delay. Our model naturally produces orphan X-ray and γ-ray flares. These are caused by flares that are only observable above the quiescent jet emission in a narrow band of frequencies. Our model is able to successfully fit to the observed multiwavelength flaring spectra and light curves of PKS1502+106 across all wavelengths, using a transient flaring front located within the broad-line region.

Experimental 'jet lag' inhibits adult neurogenesis and produces long-term cognitive deficits in female hamsters.

PubMed

Gibson, Erin M; Wang, Connie; Tjho, Stephanie; Khattar, Neera; Kriegsfeld, Lance J

2010-12-01

Circadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including marked deficits in human cognitive function. Despite anecdotal and correlational reports suggesting a negative impact of circadian disruptions on brain function, this possibility has not been experimentally examined. In the present study, we investigated whether experimental 'jet lag' (i.e., phase advances of the light:dark cycle) negatively impacts learning and memory and whether any deficits observed are associated with reductions in hippocampal cell proliferation and neurogenesis. Because insults to circadian timing alter circulating glucocorticoid and sex steroid concentrations, both of which influence neurogenesis and learning/memory, we assessed the contribution of these endocrine factors to any observed alterations. Circadian disruption resulted in pronounced deficits in learning and memory paralleled by marked reductions in hippocampal cell proliferation and neurogenesis. Significantly, deficits in hippocampal-dependent learning and memory were not only seen during the period of the circadian disruption, but also persisted well after the cessation of jet lag, suggesting long-lasting negative consequences on brain function. Together, these findings support the view that circadian disruptions suppress hippocampal neurogenesis via a glucocorticoid-independent mechanism, imposing pronounced and persistent impairments on learning and memory.

Characteristics associated with Sleep Duration, Chronotype, and Social jet lag in Adolescents

PubMed Central

Malone, Susan Kohl; Zemel, Babette S.; Compher, Charlene; Souders, Margaret; Chittams, Jesse; Thompson, Aleda Leis; Lipman, Terri H.

2015-01-01

Sleep is a complex behavior with numerous health implications. Identifying socio-demographic and behavioral characteristics of sleep are important for determining those at greatest risk for sleep-related health disparities. In this cross-sectional study, general linear models were used to examine socio-demographic and behavioral characteristics associated with sleep duration, chronotype, and social jet lag in adolescents. One hundred fifteen participants completed Phase I (self-reported sleep measures); 69 of these participants completed Phase II (actigraphy-estimated sleep measures). Black adolescents had shorter free night sleep than Hispanics. Youth with later chronotypes ate fewer fruits and vegetables, drank more soda, were less physically active, and took more daytime naps. Based on these findings, recommendations for individual support and school policies are provided. PMID:26376832

Resynchronization of circadian oscillators and the east-west asymmetry of jet-lag

NASA Astrophysics Data System (ADS)

Lu, Zhixin; Klein-Cardeña, Kevin; Lee, Steven; Antonsen, Thomas M.; Girvan, Michelle; Ott, Edward

2016-09-01

Cells in the brain's Suprachiasmatic Nucleus (SCN) are known to regulate circadian rhythms in mammals. We model synchronization of SCN cells using the forced Kuramoto model, which consists of a large population of coupled phase oscillators (modeling individual SCN cells) with heterogeneous intrinsic frequencies and external periodic forcing. Here, the periodic forcing models diurnally varying external inputs such as sunrise, sunset, and alarm clocks. We reduce the dimensionality of the system using the ansatz of Ott and Antonsen and then study the effect of a sudden change of clock phase to simulate cross-time-zone travel. We estimate model parameters from previous biological experiments. By examining the phase space dynamics of the model, we study the mechanism leading to the difference typically experienced in the severity of jet-lag resulting from eastward and westward travel.

Taking the Lag out of Jet Lag through Model-Based Schedule Design

PubMed Central

Dean, Dennis A.; Forger, Daniel B.; Klerman, Elizabeth B.

2009-01-01

Travel across multiple time zones results in desynchronization of environmental time cues and the sleep–wake schedule from their normal phase relationships with the endogenous circadian system. Circadian misalignment can result in poor neurobehavioral performance, decreased sleep efficiency, and inappropriately timed physiological signals including gastrointestinal activity and hormone release. Frequent and repeated transmeridian travel is associated with long-term cognitive deficits, and rodents experimentally exposed to repeated schedule shifts have increased death rates. One approach to reduce the short-term circadian, sleep–wake, and performance problems is to use mathematical models of the circadian pacemaker to design countermeasures that rapidly shift the circadian pacemaker to align with the new schedule. In this paper, the use of mathematical models to design sleep–wake and countermeasure schedules for improved performance is demonstrated. We present an approach to designing interventions that combines an algorithm for optimal placement of countermeasures with a novel mode of schedule representation. With these methods, rapid circadian resynchrony and the resulting improvement in neurobehavioral performance can be quickly achieved even after moderate to large shifts in the sleep–wake schedule. The key schedule design inputs are endogenous circadian period length, desired sleep–wake schedule, length of intervention, background light level, and countermeasure strength. The new schedule representation facilitates schedule design, simulation studies, and experiment design and significantly decreases the amount of time to design an appropriate intervention. The method presented in this paper has direct implications for designing jet lag, shift-work, and non-24-hour schedules, including scheduling for extreme environments, such as in space, undersea, or in polar regions. PMID:19543382

Adaptation to Experimental Jet-Lag in R6/2 Mice despite Circadian Dysrhythmia

PubMed Central

Wood, Nigel I.; McAllister, Catherine J.; Cuesta, Marc; Aungier, Juliet; Fraenkel, Eloise; Morton, A. Jennifer

2013-01-01

The R6/2 transgenic mouse model of Huntington’s disease (HD) shows a disintegration of circadian rhythms that can be delayed by pharmacological and non-pharmacological means. Since the molecular machinery underlying the circadian clocks is intact, albeit progressively dysfunctional, we wondered if light phase shifts could modulate the deterioration in daily rhythms in R6/2 mice. Mice were subjected to four x 4 hour advances in light onset. R6/2 mice adapted to phase advances, although angles of entrainment increased with age. A second cohort was subjected to a jet-lag paradigm (6 hour delay or advance in light onset, then reversal after 2 weeks). R6/2 mice adapted to the original shift, but could not adjust accurately to the reversal. Interestingly, phase shifts ameliorated the circadian rhythm breakdown seen in R6/2 mice under normal LD conditions. Our previous finding that the circadian period (tau) of 16 week old R6/2 mice shortens to approximately 23 hours may explain how they adapt to phase advances and maintain regular circadian rhythms. We tested this using a 23 hour period light/dark cycle. R6/2 mice entrained to this cycle, but onsets of activity continued to advance, and circadian rhythms still disintegrated. Therefore, the beneficial effects of phase-shifting are not due solely to the light cycle being closer to the tau of the mice. Our data show that R6/2 mice can adapt to changes in the LD schedule, even beyond the age when their circadian rhythms would normally disintegrate. Nevertheless, they show abnormal responses to changes in light cycles. These might be caused by a shortened tau, impaired photic re-synchronization, impaired light detection and/or reduced masking by evening light. If similar abnormalities are present in HD patients, they may suffer exaggerated jet-lag. Since the underlying molecular clock mechanism remains intact, light may be a useful treatment for circadian dysfunction in HD. PMID:23390510

Advancing circadian rhythms before eastward flight: a strategy to prevent or reduce jet lag.

PubMed

Eastman, Charmane I; Gazda, Clifford J; Burgess, Helen J; Crowley, Stephanie J; Fogg, Louis F

2005-01-01

To develop a practical pre-eastward flight treatment to advance circadian rhythms as much as possible but not misalign them with sleep. One group had their sleep schedule advanced by 1 hour per day and another by 2 hours per day. Baseline at home, treatment in lab. Young healthy adults (11 men, 15 women) between the ages of 22 and 36 years. Three days of a gradually advancing sleep schedule (1 or 2 hours per day) plus intermittent morning bright light (one-half hour approximately 5000 lux, one-half hour of <60 lux) for 3.5 hours. The dim light melatonin onset was assessed before and after the 3-day treatment. Subjects completed daily sleep logs and symptom questionnaires and wore wrist activity monitors. The dim light melatonin onset advanced more in the 2-hours-per-day group than in the 1-hour-per-day group (median phase advances of 1.9 and 1.4 hours), but the difference between the means (1.8 and 1.5 hours) was not statistically significant. By the third treatment day, circadian rhythms were misaligned relative to the sleep schedule, and subjects had difficulty falling asleep in the 2-hours-per-day group, but this was not the case in the 1-hour-per-day group. Nevertheless, the 2-hours-per-day group did slightly better on the symptom questionnaires. In general, sleep disturbance and other side effects were small. A gradually advancing sleep schedule with intermittent morning bright light can be used to advance circadian rhythms before eastward flight and, thus, theoretically, prevent or reduce subsequent jet lag. Given the morning light treatment used here, advancing the sleep schedule 2 hours per day is not better than advancing it 1 hour per day because it was too fast for the advance in circadian rhythms. A diagram is provided to help the traveler plan a preflight schedule.

Burst Statistics Using the Lag-Luminosity Relationship

NASA Technical Reports Server (NTRS)

Band, D. L.; Norris, J. P.; Bonnell, J. T.

2003-01-01

Using the lag-luminosity relation and various BATSE catalogs we create a large catalog of burst redshifts, peak luminosities and emitted energies. These catalogs permit us to evaluate the lag-luminosity relation, and to study the burst energy distribution. We find that this distribution can be described as a power law with an index of alpha = 1.76 +/- 0.05 (95% confidence), close to the alpha = 2 predicted by the original quasi-universal jet model.

Long-Lag, Wide-pulse Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Norris, J. P.; Bonnell, J. T.; Kazanas, D.; Scargie, J. D.; Hakkila, J.; Giblin, T. W.

2005-01-01

The best available probe of the early phase of gamma-ray burst (GRB) jet attributes is the prompt gamma-ray emission, in which several intrinsic and extrinsic variables determine observed GRB pulse evolution, including at least: jet opening angle, profiles of Lorentz factor and matter/field density, distance of emission region from central source, and viewing angle. Bright, usually complex bursts have many narrow pulses that are difficult to model due to overlap. However, the relatively simple, long spectral lag, wide-pulse bursts may have simpler physics and are easier to model. We have analyzed the temporal and spectral behavior of wide pulses in 24 long-lag bursts from the BATSE sample, using a pulse model with two shape parameters - width and asymmetry - and the Band spectral model with three shape parameters. We find that pulses in long-lag bursts are distinguished both temporally and spectrally from those in bright bursts: the pulses in long spectral lag bursts are few in number, and approximately 100 times wider (10s of seconds), have systemtically lower peaks in nu*F(nu), harder low-energy spectra and softer high-energy spectra. These five pulse descriptors are essentially uncorrelated for our long-lag sample, suggesting that at least approximately 5 parameters are needed to model burst temporal and spectral behavior, roughly commensurate with the theoretical phase space. However, we do find that pulse width is strongly correlated with spectral lag; hence these two parameters may be viewed as mutual surrogates. The prevalence of long-lag bursts near the BATSE trigger threshold, their predominantly low nu*F(nu) spectral peaks, and relatively steep upper power-law spectral indices indicate that Swiift will detect many such bursts.

Implications of Lag-Luminosity Relationship for Unified GRB Paradigms

NASA Technical Reports Server (NTRS)

Norris, J. P.; White, Nicholas E. (Technical Monitor)

2002-01-01

Spectral lags (tau(sub lag)) are deduced for 1437 long (T(sub 90) greater than 2 s) BATSE gamma-ray bursts (GRBs) with peak flux F(sub p) greater than 0.25 photons cm(sup -2)/s, near to the BATSE trigger threshold. The lags are modeled to approximate the observed distribution in the F(sub p)-T(sub lag) plane, realizing a noise-free representation. Assuming a two-branch lag-luminosity relationship, the lags are self-consistently corrected for cosmological effects to yield distributions in luminosity, distance, and redshift. The results have several consequences for GRB populations and for unified gamma-ray/afterglow scenarios which would account for afterglow break times and gamma-ray spectral evolution in terms of jet opening angle, viewing angle, or a profiled jet with variable Lorentz factor: A component of the burst sample is identified - those with few, wide pulses, lags of a few tenths to several seconds, and soft spectra - whose Log[N]-Log[F(sub p)] distribution approximates a -3/2 power-law, suggesting homogeneity and thus relatively nearby sources. The proportion of these long-lag bursts increases from negligible among bright BATSE bursts to approx. 50% at trigger threshold. Bursts with very long lags, approx. 1-2 less than tau(sub lag) (S) less than 10, show a tendency to concentrate near the Supergalactic Plane with a quadrupole moment of approx. -0.10 +/- 0.04. GRB 980425 (SN 1998bw) is a member of this subsample of approx. 90 bursts with estimated distances less than 100 Mpc. The frequency of the observed ultra-low luminosity bursts is approx. 1/4 that of SNe Ib/c within the same volume. If truly nearby, the core-collapse events associated with these GRBs might produce gravitational radiation detectable by LIGO-II. Such nearby bursts might also help explain flattening of the cosmic ray spectrum at ultra-high energies, as observed by AGASA.

ON THE ORIGIN OF THE {gamma}-RAY/OPTICAL LAGS IN LUMINOUS BLAZARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Janiak, Mateusz; Sikora, Marek; Moderski, Rafal

2012-12-01

Blazars are strongly variable sources that occasionally show spectacular flares visible in various energy bands. These flares are often, but not always, correlated. In a number of cases, the peaks of optical flares are found to be somewhat delayed with respect to the {gamma}-ray peaks. One notable example of such a delay was found in 3C 279 by Hayashida et al. and interpreted as a result of steeper drop with a distance of the energy density of an external radiation field than of the magnetic energy density. In this paper, we demonstrate that, in general, depending on the respective energymore » density profile along the jet, such lags can have both signs and that they can take place for any ratio of these energy densities. We study the dependence of such lags on the ratio of these energy densities at a distance of a maximal energy dissipation in a jet, on their gradients, as well as on the time profile of the relativistic electron injection within the moving source. We show how prominent such lags can be, and their expected timescales. We suggest that studies of such lags can provide a powerful tool to resolve the structure of relativistic jets and their radiative environment. As an example we model the lag observed in 3C 279, showing that in this object the flare is produced at a distance of a few parsecs from the central black hole, consistent with our previous inferences based on the spectra and optical polarization properties.« less

Effectiveness of Circadian countermeasures in simulated transmeridian flight schedules

NASA Technical Reports Server (NTRS)

Moline, Margaret L.; Monk, Timothy H.

1989-01-01

The symptoms of jet-lag commonly afflict travelers who cross time zones. Insomnia during the new night, daytime fatigue, malaise, sleepiness, and gastrointestinal disturbances can occur for as long as 3 weeks after jet travel across even a few time zones. These symptoms are largely due to the slow rate of adjustment of the internal circadian timing system to the new time zone. Since business (or pleasure) can be seriously interrupted by such symptoms, it is important to determine ways to speed up the adjustment process to ameliorate the symptoms. Airline pilots have reported that they frequently nap to counter jet lag symptoms, and that they view this as a useful technique. Napping as a countermeasure would be attractive since it is practical and would take advantage of a naturally occurring phase of sleepiness after lunch. Napping also makes sense since insomnia is a common jet lag symptom. Thus, a laboratory simulation of jet lag was designed to test the ability of napping to increase the rate of adjustment following a time zone shift in a population of middle-aged men.

Longitudinal cross-lagged relationships between mindfulness, posttraumatic stress symptoms, and posttraumatic growth in adolescents following the Yancheng tornado in China.

PubMed

An, Yuanyuan; Yuan, Guangzhe; Zhang, Na; Xu, Wei; Liu, Zhen; Zhou, Feng

2018-08-01

Treatment of posttraumatic stress symptoms and facilitation of posttraumatic growth are two encouraging areas of research, yet little is understood about the relationships between trait mindfulness, posttraumatic stress symptoms, and posttraumatic growth. Previous work suggests the linkages among these variables, but most studies have been conducted in adult samples. The aim of this study was to examine longitudinal cross-lagged relationships between mindfulness, posttraumatic stress symptoms, and posttraumatic growth among adolescent survivors of the 2016 Jiangsu tornado in China. Data was collected at two secondary schools located in Yancheng city, where the severe catastrophic damage occurred during the tornado. The sample included 247 adolescent survivors (59.5% girls) aged 12-14 years who were directly affected by the tornado. Participants self-reported their trait mindfulness, posttraumatic stress symptoms, and posttraumatic growth at two time points: 6-month (T1) and 9-month post-tornado (T2; attrition rate 17.4%). Cross-lagged structural equation modelling analyses were conducted. Results showed that posttraumatic stress symptoms at T1 significantly predicted reduced trait mindfulness at T2 but not posttraumatic growth; trait mindfulness at T1 did not significantly predict posttraumatic stress symptoms nor posttraumatic growth at T2; and posttraumatic growth at T1 did not predict trait mindfulness nor posttraumatic stress symptoms at T2. These findings suggested that posttraumatic stress symptoms may negatively influence the development of trait mindfulness in disaster-affected adolescents in China, and that posttraumatic growth may have unique implications for this young population which was not associated with posttraumatic stress symptoms or trait mindfulness. Copyright © 2018 Elsevier B.V. All rights reserved.

Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag DisordersAn American Academy of Sleep Medicine Review

PubMed Central

Sack, Robert L; Auckley, Dennis; Auger, R. Robert; Carskadon, Mary A.; Wright, Kenneth P.; Vitiello, Michael V.; Zhdanova, Irina V.

2007-01-01

Objective: This the first of two articles reviewing the scientific literature on the evaluation and treatment of circadian rhythm sleep disorders (CRSDs), employing the methodology of evidence-based medicine. In this first part of this paper, the general principles of circadian biology that underlie clinical evaluation and treatment are reviewed. We then report on the accumulated evidence regarding the evaluation and treatment of shift work disorder (SWD) and jet lag disorder (JLD). Methods: A set of specific questions relevant to clinical practice were formulated, a systematic literature search was performed, and relevant articles were abstracted and graded. Results: A substantial body of literature has accumulated that provides a rational basis the evaluation and treatment of SWD and JLD. Physiological assessment has involved determination of circadian phase using core body temperature and the timing of melatonin secretion. Behavioral assessment has involved sleep logs, actigraphy and the Morningness-Eveningness Questionnaire (MEQ). Treatment interventions fall into three broad categories: 1) prescribed sleep scheduling, 2) circadian phase shifting (“resetting the clock”), and 3) symptomatic treatment using hypnotic and stimulant medications. Conclusion: Circadian rhythm science has also pointed the way to rational interventions for the SWD and JLD, and these treatments have been introduced into the practice of sleep medicine with varying degrees of success. More translational research is needed using subjects who meet current diagnostic criteria. Citation: Sack RL; Auckley D; Auger RR; Carskadon MA; Wright KP; Vitiello MV; Zhdanova IV. Circadian rhythm sleep disorders: Part I, basic principles, shift work and jet lag disorders. SLEEP 2007;30(11):1460-1483. PMID:18041480

Cross-Lagged Associations Between Adolescents' Depressive Symptoms and Negative Cognitive Style: The Role of Negative Life Events.

PubMed

Kindt, Karlijn C M; Kleinjan, Marloes; Janssens, Jan M A M; Scholte, Ron H J

2015-11-01

Previous research has established that cognitive theory-based depression prevention programs aiming change in negative cognitive style in early adolescents do not have strong effects in universal settings. Although theories suggest that a negative cognitive style precedes depressive symptoms, empirical findings are mixed. We hypothesized that negative cognitive style may not predict depressive symptoms in adolescents with normative depressive symptoms. Depressive symptoms, negative cognitive style and dependent negative life events were assessed in young adolescents (N = 1343; mean age = 13.4 years, SD = 0.77; 52.3 % girls) at four time points over an 18-month period. Using a cross-lagged panel design, results revealed that depressive symptoms predicted a negative cognitive style but not vice versa. However, when including dependent negative life events as a variable, depressive symptoms did not prospect a negative cognitive style consistently. When dependent negative life events were used as a time-varying covariate, depressive symptoms and a negative cognitive style were not related. We concluded that negative cognitive style is not predictive of depressive symptoms in a community sample of young adolescents. Moreover, the findings suggest that longitudinal relationships between depressive symptoms and a negative cognitive style are not meaningful when dependent negative life events are not considered.

Long-Lag, Wide-pulse Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Norris, J. P.; Bonnell, J. T.; Kazanas, D.; Scargle, . D.; Hakkila, J.; Giblin, T. W.

2004-01-01

Currently, the best available probe of the early phase of gamma-ray burst (GRB) jet attributes is the prompt gamma-ray emission, in which several intrinsic and extrinsic variables determine GRB pulse evolution. Bright, usually complex bursts have many narrow pulses that are difficult to model due to overlap. However, the relatively simple, long spectral lag, wide-pulse bursts may have simpler physics and are easier to model. In this work we analyze the temporal and spectral behavior of wide pulses in 24 long-lag bursts, using a pulse model with two shape parameters - width and asymmetry - and the Band spectral model with three shape parameters. We find that pulses in long-lag bursts are distinguished both temporally and spectrally from those in bright bursts: the pulses in long spectral lag bursts are few in number, and approximately 100 times wider (10s of seconds), have systematically lower peaks in vF(v), harder low-energy spectra and softer high-energy spectra. We find that these five pulse descriptors are essentially uncorrelated for our long-lag sample, suggesting that at least approximately 5 parameters are needed to model burst temporal and spectral behavior. However, pulse width is strongly correlated with spectral lag; hence these two parameters may be viewed as mutual surrogates. We infer that accurate formulations for estimating GRB luminosity and total energy will depend on several gamma-ray attributes, at least for long-lag bursts. The prevalence of long-lag bursts near the BATSE trigger threshold, their predominantly low vF(v) spectral peaks, and relatively steep upper power-law spectral indices indicate that Swift will detect many such bursts.

Time-dependent Electron Acceleration in Blazar Transients: X-Ray Time Lags and Spectral Formation

NASA Astrophysics Data System (ADS)

Lewis, Tiffany R.; Becker, Peter A.; Finke, Justin D.

2016-06-01

Electromagnetic radiation from blazar jets often displays strong variability, extending from radio to γ-ray frequencies. In a few cases, this variability has been characterized using Fourier time lags, such as those detected in the X-rays from Mrk 421 using BeppoSAX. The lack of a theoretical framework to interpret the data has motivated us to develop a new model for the formation of the X-ray spectrum and the time lags in blazar jets based on a transport equation including terms describing stochastic Fermi acceleration, synchrotron losses, shock acceleration, adiabatic expansion, and spatial diffusion. We derive the exact solution for the Fourier transform of the electron distribution and use it to compute the Fourier transform of the synchrotron radiation spectrum and the associated X-ray time lags. The same theoretical framework is also used to compute the peak flare X-ray spectrum, assuming that a steady-state electron distribution is achieved during the peak of the flare. The model parameters are constrained by comparing the theoretical predictions with the observational data for Mrk 421. The resulting integrated model yields, for the first time, a complete first-principles physical explanation for both the formation of the observed time lags and the shape of the peak flare X-ray spectrum. It also yields direct estimates of the strength of the shock and the stochastic magnetohydrodynamical wave acceleration components in the Mrk 421 jet.

TIME-DEPENDENT ELECTRON ACCELERATION IN BLAZAR TRANSIENTS: X-RAY TIME LAGS AND SPECTRAL FORMATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, Tiffany R.; Becker, Peter A.; Finke, Justin D., E-mail: pbecker@gmu.edu, E-mail: tlewis13@gmu.edu, E-mail: justin.finke@nrl.navy.mil

2016-06-20

Electromagnetic radiation from blazar jets often displays strong variability, extending from radio to γ -ray frequencies. In a few cases, this variability has been characterized using Fourier time lags, such as those detected in the X-rays from Mrk 421 using Beppo SAX. The lack of a theoretical framework to interpret the data has motivated us to develop a new model for the formation of the X-ray spectrum and the time lags in blazar jets based on a transport equation including terms describing stochastic Fermi acceleration, synchrotron losses, shock acceleration, adiabatic expansion, and spatial diffusion. We derive the exact solution formore » the Fourier transform of the electron distribution and use it to compute the Fourier transform of the synchrotron radiation spectrum and the associated X-ray time lags. The same theoretical framework is also used to compute the peak flare X-ray spectrum, assuming that a steady-state electron distribution is achieved during the peak of the flare. The model parameters are constrained by comparing the theoretical predictions with the observational data for Mrk 421. The resulting integrated model yields, for the first time, a complete first-principles physical explanation for both the formation of the observed time lags and the shape of the peak flare X-ray spectrum. It also yields direct estimates of the strength of the shock and the stochastic magnetohydrodynamical wave acceleration components in the Mrk 421 jet.« less

Work gets unfair for the depressed: cross-lagged relations between organizational justice perceptions and depressive symptoms.

PubMed

Lang, Jessica; Bliese, Paul D; Lang, Jonas W B; Adler, Amy B

2011-05-01

The organizational justice literature has consistently documented substantial correlations between organizational justice and employee depression. Existing theoretical literature suggests this relationship occurs because perceptions of organizational (in)justice lead to subsequent psychological health problems. Building on recent research on the affective nature of justice perceptions, in the present research we broaden this perspective by arguing there are also theoretical arguments for a reverse effect whereby psychological health problems influence perceptions of organizational justice. To contrast both theoretical perspectives, we test longitudinal lagged effects between organizational justice perceptions (i.e., distributive justice, interactional justice, interpersonal justice, informational justice, and procedural justice) and employee depressive symptoms using structural equation modeling. Analyses of 3 samples from different military contexts (N₁ = 625, N₂ = 134, N₃ = 550) revealed evidence of depressive symptoms leading to subsequent organizational justice perceptions. In contrast, the opposite effects of organizational justice perceptions on depressive symptoms were not significant for any of the justice dimensions. The findings have broad implications for theoretical perspectives on psychological health and organizational justice perceptions.

Ready for takeoff? A critical review of armodafinil and modafinil for the treatment of sleepiness associated with jet lag

PubMed Central

McCarty, David E

2010-01-01

Jet lag syndrome (JLS) is a clinical syndrome of disrupted nocturnal sleep and daytime neurocognitive impairment which occurs in the context of rapid transmeridian travel. Many strategies for treatment of JLS exist, and include hypnotics to enhance nocturnal sleep, chronotherapeutic approaches (eg, light therapy, melatonin, or gradual schedule shifting), and alerting agents to counter daytime sleepiness. Safety concerns have prompted renewed interest in managing JLS-associated excessive daytime sleepiness (JLSAEDS). Off-label use of the newer alerting agents modafinil and armodafinil is increasing for this indication, often at the specific request of patients. In order to better evaluate the potential risks and benefits of these medications for the management of JLSAEDS, clinicians must be aware of what is known – and still not known. In this article, the pharmacology and pharmacokinetics of modafinil and armodafinil are reviewed, along with evidence for their efficacy in treating sleepiness associated with narcolepsy, obstructive sleep apnea and shift work sleep disorder. Clinical trial data for use of alerting agents in the management of JLSAEDS are limited to one three-day trial involving armodafinil, dosed in the morning to treat JLSAEDS in the setting of eastbound transmeridian travel. This study showed improvement in objective measures of daytime sleepiness at doses of 50 and 150 mg per day. However, global impression of clinical severity of symptom scores only improved on day 1 for those patients receiving 150 mg, and were otherwise not superior to placebo. Consideration for the use of modafinil or armodafinil for the treatment of sleepiness associated with JLS involves careful integration of patient-reported goals, a review of medical contraindications, and an awareness of rare adverse events. More research is needed in order to identify those who are most likely to benefit from this intervention and better define the risk-benefit ratio for this

Sleep Disorders and Complementary Health Approaches : What the Science Says

MedlinePlus

... symptoms of jet lag and improve sleep following travel across multiple time zones. A 2009 Cochrane review supporting this recommendation ... oral melatonin for alleviating jet lag after air travel across several time zones, and concluded that melatonin is remarkably effective ...

Longitudinal Relationship between Self-efficacy and Posttraumatic Stress Symptoms 8 Years after a Violent Assault: An Autoregressive Cross-Lagged Model.

PubMed

Nygaard, Egil; Johansen, Venke A; Siqveland, Johan; Hussain, Ajmal; Heir, Trond

2017-01-01

Self-efficacy is assumed to promote posttraumatic adaption, and several cross-sectional studies support this notion. However, there is a lack of prospective longitudinal studies to further illuminate the temporal relationship between self-efficacy and posttraumatic stress symptoms. Thus, an important unresolved research question is whether posttraumatic stress disorder (PTSD) symptoms affect the level of self-efficacy or vice versa or whether they mutually influence each other. The present prospective longitudinal study investigated the reciprocal relationship between general self-efficacy (GSE) and posttraumatic stress symptoms in 143 physical assault victims. We used an autoregressive cross-lagged model across four assessment waves: within 4 months after the assault (T1) and then 3 months (T2), 12 months (T3) and 8 years (T4) after the first assessment. Stress symptoms at T1 and T2 predicted subsequent self-efficacy, while self-efficacy at T1 and T2 was not related to subsequent stress symptoms. These relationships were reversed after T3; higher levels of self-efficacy at T3 predicted lower levels of posttraumatic stress symptoms at T4, while posttraumatic tress symptoms at T3 did not predict self-efficacy at T4. In conclusion, posttraumatic stress symptoms may have a deteriorating effect on self-efficacy in the early phase after physical assault, whereas self-efficacy may promote recovery from posttraumatic stress symptoms over the long term.

Experimental exploration of underexpanded supersonic jets

NASA Astrophysics Data System (ADS)

André, Benoît; Castelain, Thomas; Bailly, Christophe

2014-01-01

Two underexpanded free jets at fully expanded Mach numbers = 1.15 and 1.50 are studied. Schlieren visualizations as well as measurements of static pressure, Pitot pressure and velocity are performed. All these experimental techniques are associated to obtain an accurate picture of the jet flow development. In particular, expansion, compression and neutral zones have been identified in each shock cell. Particle lag is considered by integrating the equation of motion for particles in a fluid flow and it is found that the laser Doppler velocimetry is suitable for investigating shock-containing jets. Even downstream of the normal shock arising in the = 1.50 jet, the measured gradual velocity decrease is shown to be relevant.

Longitudinal Relationship between Self-efficacy and Posttraumatic Stress Symptoms 8 Years after a Violent Assault: An Autoregressive Cross-Lagged Model

PubMed Central

Nygaard, Egil; Johansen, Venke A.; Siqveland, Johan; Hussain, Ajmal; Heir, Trond

2017-01-01

Self-efficacy is assumed to promote posttraumatic adaption, and several cross-sectional studies support this notion. However, there is a lack of prospective longitudinal studies to further illuminate the temporal relationship between self-efficacy and posttraumatic stress symptoms. Thus, an important unresolved research question is whether posttraumatic stress disorder (PTSD) symptoms affect the level of self-efficacy or vice versa or whether they mutually influence each other. The present prospective longitudinal study investigated the reciprocal relationship between general self-efficacy (GSE) and posttraumatic stress symptoms in 143 physical assault victims. We used an autoregressive cross-lagged model across four assessment waves: within 4 months after the assault (T1) and then 3 months (T2), 12 months (T3) and 8 years (T4) after the first assessment. Stress symptoms at T1 and T2 predicted subsequent self-efficacy, while self-efficacy at T1 and T2 was not related to subsequent stress symptoms. These relationships were reversed after T3; higher levels of self-efficacy at T3 predicted lower levels of posttraumatic stress symptoms at T4, while posttraumatic tress symptoms at T3 did not predict self-efficacy at T4. In conclusion, posttraumatic stress symptoms may have a deteriorating effect on self-efficacy in the early phase after physical assault, whereas self-efficacy may promote recovery from posttraumatic stress symptoms over the long term. PMID:28620334

Posttraumatic cognitions and posttraumatic stress symptoms among war-affected children: a cross-lagged analysis.

PubMed

Palosaari, Esa; Punamäki, Raija-Leena; Diab, Marwan; Qouta, Samir

2013-08-01

In a longitudinal study of war-affected children, we tested, first, whether posttraumatic cognitions (PTCs) mediated the relationship between initial and later posttraumatic stress symptoms (PTSSs). Second, we analyzed the relative strength of influences that PTCs and PTSSs have on each other in cross-lagged models of levels and latent change scores. The participants were 240 Palestinian children 10-12 years of age, reporting PTSSs and PTCs measures at 3, 5, and 11 months after a major war. Results show that PTCs did not mediate between initial and later PTSSs. The levels and changes in PTCs statistically significantly predicted later levels and changes in PTSSs, but PTSSs did not statistically significantly predict later PTCs. The results are consistent with the hypothesis that PTCs have a central role in the development and maintenance of PTSSs over time, but they do not support the hypothesis that initial PTSSs develop to chronic PTSSs through negative PTCs. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Dynamic response of induced pressures, suckdown, and temperatures for two tandem jet STOVL configurations

NASA Technical Reports Server (NTRS)

Wardwell, Douglas A.; Corsiglia, Victor R.; Kuhn, Richard E.

1992-01-01

NASA Ames Research Center has been conducting a program to improve the methods for predicting the jet-induced lift loss (suckdown) and hot gas ingestion on jet Short Takeoff and Vertical Landing (STOVL) aircraft during hover near the ground. As part of that program, small-scale hover tests were conducted to expand the current data base and to improve upon the current empirical methods for predicting jet-induced lift loss and hot gas ingestion (HGI) effects. This report is one of three data reports covering data obtained from hover tests conducted at Lockheed Aeronautical Systems, Rye Canyon Facility. It will include dynamic (time dependent) test data for both lift loss and HGI parameters (height, nozzle temperature, nozzle pressure ratio, and inlet location). The flat plate models tested were tandem jet configurations with three planform variations and variable position side-by-side sucking inlets mounted above the planform. Temperature time lags from 8-15 seconds were observed before the model temperatures stabilize. This was larger than the expected 1.5-second lag calculated from literature. Several possible explanations for the flow temperatures to stabilize may include some, or all, of the following: thermocouple lag, radiation to the model surface, and heat loss to the ground board. Further investigations are required to understand the reasons for this temperature lag.

Discovery of a Time Lag between the Soft X-Ray and Radio Emission of the Tidal Disruption Flare ASASSN-14li: Evidence for Linear Disk–Jet Coupling

NASA Astrophysics Data System (ADS)

Pasham, Dheeraj R.; van Velzen, Sjoert

2018-03-01

The tidal disruption of a star by a supermassive black hole can result in transient radio emission. The electrons producing these synchrotron radio flares could either be accelerated inside a relativistic jet or externally by shocks resulting from an outflow interacting with the circumnuclear medium. Until now, evidence for the internal emission mechanism has been lacking; nearly all tidal disruption flare studies have adopted the external shock model to explain the observed properties of radio flares. Here we report a result that presents a challenge to external emission models: we discovered a cross-correlation between the soft X-ray (0.3–1 keV) and 16 GHz radio flux of the tidal disruption flare ASASSN-14li. Variability features in the X-ray light curve appear again in the radio light curve, but after a time lag of {12}-5+6 days. This demonstrates that the soft X-ray-emitting accretion disk regulates the radio emission. This coupling appears to be inconsistent with all previous external emission models for this source but is naturally explained if the radio emission originates from a freely expanding jet. We show that emission internal to an adiabatically expanding jet can also reproduce the observed evolution of the radio spectral energy distribution. Furthermore, both the correlation between X-ray and radio luminosity as well as our radio spectral modeling imply an approximately linear coupling between the accretion rate and jet power.

Dimensions of Peer Sexual Harassment Victimization and Depressive Symptoms in Adolescence: A Longitudinal Cross-Lagged Study in a Swedish Sample.

PubMed

Dahlqvist, Heléne Zetterström; Landstedt, Evelina; Young, Robert; Gådin, Katja Gillander

2016-05-01

Sexual harassment is commonly considered unwanted sexual attention and a form of gender-based violence that can take physical, verbal and visual forms and it is assumed to cause later depression in adolescents. There is a dearth of research explicitly testing this assumption and the directional pathway remains unclear. The purpose of this study was to use a feminist theoretical framework to test competing models in respect of the direction of the relationships between dimensions of peer sexual harassment victimization and dimensions of depressive symptoms from ages 14 to 16 in adolescents. The study also aimed to investigate gender differences in these pathways. Cross-lagged models were conducted using a three-wave (2010, 2011 and 2012) longitudinal study of 2330 students (51 % females) from Sweden, adjusted for social background. Girls subjected to sexual harassment in grade seven continued to experience sexual harassment the following 2 years. There was weaker evidence of repeated experience of sexual harassment among boys. Depressive symptoms were stable over time in both genders. Sexual name-calling was the dimension that had the strongest associations to all dimensions of depressive symptoms irrespective of gender. In girls, name-calling was associated with later somatic symptoms and negative affect, while anhedonia (reduced ability to experience pleasure) preceded later name-calling. Physical sexual harassment had a reciprocal relationship to somatic symptoms in girls. In boys, name-calling was preceded by all dimensions of depressive symptoms. It is an urgent matter to prevent sexual harassment victimization, as it is most likely to both cause depressive symptoms or a reciprocal cycle of victimization and depression symptoms in girls as well as boys.

Investigation of Spectral Lag and Epeak as Joint Luminosity Indicators in GRBs

NASA Technical Reports Server (NTRS)

White, Nicholas E. (Technical Monitor); Norris, Jay P.

2003-01-01

Models for gamma-ray bursts which invoke jetted, colliding shells would appear to have at least two determinants for luminosity, e.g., observer viewing angle and Lorentz factor, or possibly shell mass. The latter two internal physical parameters may vary from pulse to pulse within a burst, and such variation might be reflected in evolution of observables such as spectral lag and peak in the spectral energy distribution. We analyze bright BATSE bursts using the 16-channel medium energy resolution (MER) data, with time resolutions of 16 and 64 ms, measuring spectral lags and peak energies for significant pulse structures within a burst, identified using a Bayesian block algorithm. We then explore correlations between the measured parameters and total flux for the individual pulse structures.

Fluctuating pressures in flow fields of jets

NASA Technical Reports Server (NTRS)

Schroeder, J. C.; Haviland, J. K.

1976-01-01

The powered lift configurations under present development for STOL aircraft are the externally blown flap (EBF), involving direct jet impingement on the aircraft flaps, and the upper surface blown (USB), where the jet flow is attached on the upper surface of the wing and directed downwards. Towards the goal of developing scaling laws to predict unsteady loads imposed on the structural components of these STOL aircraft from small model tests, the near field fluctuating pressure behavior for the simplified cases of a round free cold jet and the same jet impinging on a flat plate was investigated. Examples are given of coherences, phase lags (giving convection velocities), and overall fluctuating pressure levels measured. The fluctuating pressure levels measured on the flat plate are compared to surface fluctuating pressure levels measured on full-scale powered-lift configuration models.

Vectoring of parallel synthetic jets

NASA Astrophysics Data System (ADS)

Berk, Tim; Ganapathisubramani, Bharathram; Gomit, Guillaume

2015-11-01

A pair of parallel synthetic jets can be vectored by applying a phase difference between the two driving signals. The resulting jet can be merged or bifurcated and either vectored towards the actuator leading in phase or the actuator lagging in phase. In the present study, the influence of phase difference and Strouhal number on the vectoring behaviour is examined experimentally. Phase-locked vorticity fields, measured using Particle Image Velocimetry (PIV), are used to track vortex pairs. The physical mechanisms that explain the diversity in vectoring behaviour are observed based on the vortex trajectories. For a fixed phase difference, the vectoring behaviour is shown to be primarily influenced by pinch-off time of vortex rings generated by the synthetic jets. Beyond a certain formation number, the pinch-off timescale becomes invariant. In this region, the vectoring behaviour is determined by the distance between subsequent vortex rings. We acknowledge the financial support from the European Research Council (ERC grant agreement no. 277472).

Cross-lagged associations between posttraumatic stress symptoms and coping self-efficacy in long-term recovery: A four-wave comparative study.

PubMed

Bosmans, Mark W G; van der Velden, Peter G

2017-11-01

Trauma-related coping self-efficacy (CSE) - in brief, the perceived ability to cope with the aftermath of a traumatic event - has been shown to affect psychological outcomes. A previous study showed that CSE affects subsequent PTSS levels, but not vice versa among a sample exposed 0-6 months ago. In this four-wave follow-up study we examined the cross-lagged relationships between CSE and posttraumatic stress symptoms (PTSS) among those exposed to PTEs (potentially traumatic events) 1-2 years before T1 in order to examine direction of influence. Research questions were: 1) what are the cross-lagged associations between CSE and PTSS levels among those exposed to PTE in the relatively long-term (1-2 years ago, called PTE long-term group), and 2) to what extent do these associations differ from the cross lagged associations among those exposed to PTE in the relatively short-term (0-6 months ago)? Study samples consist of adult respondents of a representative internet panel who experienced a PTE between 1 and 2 years before T1, and did not experience any new PTE between T1 and T3 (long-term group, N = 438) and those exposed in the six months before T1, and not exposed to any additional PTE (short-term group, N = 400). Levels of CSE and PTSS were measured with 4-month intervals. In addition, prospectively assessed personality traits and peritraumatic distress were entered in the analyses. Structural equation modeling showed that CSE perceptions will continue to influence subsequent PTSS levels in the long-term, just as they did in the short-term. Contrary to the more short-term post-exposure period however, CSE levels do not just influence recovery from PTSS. Over time, degree of PTSS experienced also influences subsequent CSE perceptions. Results suggest that while trauma-related CSE perceptions are relatively robust in the short-term recovery period, they can be affected by posttraumatic stress in the long-term. Copyright © 2017 Elsevier Ltd. All rights reserved.

The buzz-lag effect.

PubMed

Cellini, Cristiano; Scocchia, Lisa; Drewing, Knut

2016-10-01

In the flash-lag illusion, a brief visual flash and a moving object presented at the same location appear to be offset with the flash trailing the moving object. A considerable amount of studies investigated the visual flash-lag effect, and flash-lag-like effects have also been observed in audition, and cross-modally between vision and audition. In the present study, we investigate whether a similar effect can also be observed when using only haptic stimuli. A fast vibration (or buzz, lasting less than 20 ms) was applied to the moving finger of the observers and employed as a "haptic flash." Participants performed a two-alternative forced-choice (2AFC) task where they had to judge whether the moving finger was located to the right or to the left of the stationary finger at the time of the buzz. We used two different movement velocities (Slow and Fast conditions). We found that the moving finger was systematically misperceived to be ahead of the stationary finger when the two were physically aligned. This result can be interpreted as a purely haptic analogue of the flash-lag effect, which we refer to as "buzz-lag effect." The buzz-lag effect can be well accounted for by the temporal-sampling explanation of flash-lag-like effects.

Intramedullary nails with two lag screws.

PubMed

Brown, C J; Wang, C J; Yettram, A L; Procter, P

2004-06-01

To investigate the structural integrity of intramedullary nails with two lag screws, and to give guidance to orthopaedic surgeons in the choice of appropriate devices. Alternative designs of the construct are considered, and the use of a slotted upper lag screw insertion hole is analysed. Intramedullary fixation devices with a single lag screw have been known to fail at the lag screw insertion hole. Using two lag screws is considered. It has also been proposed to use a slot in the nail for the upper lag screw to prevent the upper lag screw from sticking. Bending and torsion load cases are analysed using finite element method. Consideration of both load conditions is essential. The results present the overall stiffness of the assembly, the load sharing between lag screws, and the possibility for cut-out to occur. While the slot for the upper lag screw might be advantageous with regard to the stresses in the lag screws, it could be detrimental for cut-out occurring adjacent to the lag screws. Comparative analyses demonstrate that two lag screws may be advantageous in patients whose cancellous bone quality is good and who impose large loads on the lag screw/nail interface. However, the use of two screws might pre-dispose to failure by cut-out of the lag screws. The addition of a slotted hole for the upper lag screw appears to do nothing significant to reduce the risk of such a failure. Copyright 2004 Elsevier Ltd.

The effect of bifocal add on accommodative lag in myopic children with high accommodative lag.

PubMed

Berntsen, David A; Mutti, Donald O; Zadnik, Karla

2010-12-01

To determine the effect of a bifocal add and manifest correction on accommodative lag in myopic children with high accommodative lag, who have been reported to have the greatest reduction in myopia progression with progressive addition lenses (PALs). Monocular accommodative lag to a 4-D Badal stimulus was measured on two occasions 6 months apart in 83 children (mean ± SD age, 9.9 ± 1.3 years) with high lag randomized to wearing single-vision lenses (SVLs) or PALs. Accommodative lag was measured with the following corrections: habitual, manifest, manifest with +2.00-D add, and habitual with +2.00-D add (6-month visit only). At baseline, accommodative lag was higher (1.72 ± 0.37 D; mean ± SD) when measured with manifest correction than with habitual correction (1.51 ± 0.50; P < 0.05). This higher lag with manifest correction correlated with a larger amount of habitual undercorrection at baseline (r = -0.29, P = 0.009). A +2.00-D add over the manifest correction reduced lag by 0.45 ± 0.34 D at baseline and 0.33 ± 0.38 D at the 6-month visit. Lag results at 6 months were not different between PAL and SVL wearers (P = 0.92). A +2.00-D bifocal add did not eliminate accommodative lag and reduced lag by less than 25% of the bifocal power, indicating that children mainly responded to a bifocal by decreasing accommodation. If myopic progression is substantial, measuring lag with full correction can overestimate the hyperopic retinal blur that a child most recently experienced. (ClinicalTrials.gov number, NCT00335049.).

The Effect of Bifocal Add on Accommodative Lag in Myopic Children with High Accommodative Lag

PubMed Central

Mutti, Donald O.; Zadnik, Karla

2010-01-01

Purpose. To determine the effect of a bifocal add and manifest correction on accommodative lag in myopic children with high accommodative lag, who have been reported to have the greatest reduction in myopia progression with progressive addition lenses (PALs). Methods. Monocular accommodative lag to a 4-D Badal stimulus was measured on two occasions 6 months apart in 83 children (mean ± SD age, 9.9 ± 1.3 years) with high lag randomized to wearing single-vision lenses (SVLs) or PALs. Accommodative lag was measured with the following corrections: habitual, manifest, manifest with +2.00-D add, and habitual with +2.00-D add (6-month visit only). Results. At baseline, accommodative lag was higher (1.72 ± 0.37 D; mean ± SD) when measured with manifest correction than with habitual correction (1.51 ± 0.50; P < 0.05). This higher lag with manifest correction correlated with a larger amount of habitual undercorrection at baseline (r = −0.29, P = 0.009). A +2.00-D add over the manifest correction reduced lag by 0.45 ± 0.34 D at baseline and 0.33 ± 0.38 D at the 6-month visit. Lag results at 6 months were not different between PAL and SVL wearers (P = 0.92). Conclusions. A +2.00-D bifocal add did not eliminate accommodative lag and reduced lag by less than 25% of the bifocal power, indicating that children mainly responded to a bifocal by decreasing accommodation. If myopic progression is substantial, measuring lag with full correction can overestimate the hyperopic retinal blur that a child most recently experienced. (ClinicalTrials.gov number, NCT00335049.) PMID:20688729

Externalizing Behaviour and Academic Performance--The Cross-Lagged Relationship during School Transition

ERIC Educational Resources Information Center

Palmu, Iines R.; Närhi, Vesa M.; Savolainen, Hannu K.

2018-01-01

The current study examined the over-time association between externalizing behaviour problems and academic performance during school transition in a cross-lagged design. The main focus was to reveal whether the externalizing behaviour composite and its components separately, including symptoms of CD and ADHD, differ in their relationship with…

Thermalization of mini-jets in a quark-gluon plasma

NASA Astrophysics Data System (ADS)

Iancu, Edmond; Wu, Bin

2015-10-01

We complete the physical picture for the evolution of a high-energy jet propagating through a weakly-coupled quark-gluon plasma by investigating the thermalization of the soft components of the jet. We argue that the following scenario should hold: the leading particle emits a significant number of mini-jets which promptly evolve via quasi-democratic branchings and thus degrade into a myriad of soft gluons, with energies of the order of the medium temperature T. Via elastic collisions with the medium constituents, these soft gluons relax to local thermal equilibrium with the plasma over a time scale which is considerably shorter than the typical lifetime of the mini-jet. The thermalized gluons form a tail which lags behind the hard components of the jet. We support this scenario, first, via parametric arguments and, next, by studying a simplified kinetic equation, which describes the jet dynamics in longitudinal phase-space. We solve the kinetic equation using both (semi-)analytical and numerical methods. In particular, we obtain the first exact, analytic, solutions to the ultrarelativistic Fokker-Planck equation in one-dimensional phase-space. Our results confirm the physical picture aforementioned and demonstrate the quenching of the jet via multiple branching followed by the thermalization of the soft gluons in the cascades.

The time lag and interval of discharge with a spring actuated fuel injection pump

NASA Technical Reports Server (NTRS)

Matthews, Robertson; Gardiner, A W

1923-01-01

Discussed here is research on a spring activated fuel pump for solid or airless injection with small, high speed internal combustion engines. The pump characteristics under investigation were the interval of fuel injection in terms of degrees of crank travel and in absolute time, the lag between the time the injection pump plunger begins its stroke and the appearance of the jet at the orifice, and the manner in which the fuel spray builds up to a maximum when the fuel valve is opened, and then diminishes.

Pinpointing the base of the AGN jets through general relativistic X-ray reverberation studies

NASA Astrophysics Data System (ADS)

Emmanoulopoulos, D.

2015-03-01

Many theoretical models of Active Galactic Nuclei (AGN) predict that the X-ray corona, lying above the black hole, constitutes the base of the X-ray jet. Thus, by studying the exact geometry of the close black hole environment, we can pinpoint the launching site of the jet. Detection of negative X-ray reverberation time delays (i.e. soft band X-ray variations lagging behind the corresponding hard band X-ray variations) can yield significant information about the geometrical properties of the AGN, such as the location of the X-ray source, as well as the physical properties of the the black hole, such as its mass and spin. In the frame-work of the lamp-post geometry, I present the first systematic X-ray time-lag modelling results of an ensemble of 12 AGN, using a fully general relativistic (GR) ray tracing approach for the estimation of the systems' response functions. By combing these state-of-the art GR response models with statistically innovative fitting routines, I derive the geometrical layout of the close BH environment for each source, unveiling the position of the AGN jet-base.

Effects of a 20-Min Nap Post Normal and Jet Lag Conditions on P300 Components in Athletes.

PubMed

Petit, Elisabeth; Bourdin, Hubert; Tio, Grégory; Yenil, Omer; Haffen, Emmanuel; Mougin, Fabienne

2018-05-14

Post-lunch sleepiness belongs to biological rhythms. Athletes take a nap to counteract afternoon circadian nadir, in prevision of disturbed sleep. This study examined the effects of brief post-lunch nap on vigilance in young and healthy athletes. The P300 components, physiological and cognitive performances were assessed either after nap or rest, following a night of normal sleep (NSC) or simulated jet lag condition (5-h advance-JLC). P300 wave is the positive deflection at about 300 ms in response to a rare stimulus, representing higher information processing. P300 amplitude reflects the amount of attention allocated whereas P300 latency reflects time spent on stimulus classification. P300 amplitude was significantly increased (Fz:11.14±3.0vs9.05±3.2 µV; p<0.05) and P300 latency was shorter (Pz:327.16±18.0vs344.90±17.0 ms; p<0.01) after nap in NSC. These changes were accompanied by lower subjective sleepiness (19.7±9.6vs27.5±16.5; p<0.05) and decrease in mean reaction times (MRT: divided attention, 645.1±74.2vs698±80.4 ms; p<0.05). In contrast, in JLC, only P300 amplitudes (Fz:10.30±3.1vs7.54±3.3 µV; p<0.01 and Cz: 11.48±3.1vs9.77±3.6 µV; p<0.05) increased but P300 latencies or MRT did not improve. These results indicated improvements in speed of stimulus evaluation time. Napping positively impacts on cognitive processing, especially when subjects are on normal sleep schedules. A nap should be planned for athletes whose performance requires speedy and accurate decisions. © Georg Thieme Verlag KG Stuttgart · New York.

A Cross-Lag Panel Analysis of Low Self-Esteem as a Predictor of Adolescent Internalizing Symptoms in a Prospective Longitudinal Study.

PubMed

In-Albon, Tina; Meyer, Andrea H; Metzke, Christa Winkler; Steinhausen, Hans-Christoph

2017-06-01

Self-esteem, generally regarded as an important indicator of adolescents' mental health, was assessed by a self-report questionnaire in a school sample of 593 subjects who had been assessed at 3 time points over 7 years between 11 and 25 years of age within the Zurich Psychology and Psychopathology Study (ZAPPS). Cross-lagged panel analyses of the longitudinal data from ZAPPS indicated that self-esteem was predictive of internalizing problems and had an impact on internalizing symptoms when the analyses were adjusted for coping behavior, efficiency of social networks, and impact of stressful life events. Self-esteem was also stable (r = .37-.60) within the observed age range, after controlling for prior levels of the predicted variables. The findings support the impact of self-esteem on mental health and indicate the importance of addressing self-esteem in prevention and intervention programs.

Optical Polarization and Spectral Variability in the M87 Jet

NASA Technical Reports Server (NTRS)

Perlman, Eric S.; Adams, Steven C.; Cara, Mihai; Bourque, Matthew; Harris, D. E.; Madrid, Juan P.; Simons, Raymond C.; Clausen-Brown, Eric; Cheung, C. C.; Stawarz, Lukasz;

Effect of lag time distribution on the lag phase of bacterial growth - a Monte Carlo analysis

USDA-ARS?s Scientific Manuscript database

The objective of this study is to use Monte Carlo simulation to evaluate the effect of lag time distribution of individual bacterial cells incubated under isothermal conditions on the development of lag phase. The growth of bacterial cells of the same initial concentration and mean lag phase durati...

A way around the Nyquist lag

NASA Astrophysics Data System (ADS)

Penland, C.

2017-12-01

One way to test for the linearity of a multivariate system is to perform Linear Inverse Modeling (LIM) to a multivariate time series. LIM yields an estimated operator by combining a lagged covariance matrix with the contemporaneous covariance matrix. If the underlying dynamics is linear, the resulting dynamical description should not depend on the particular lag at which the lagged covariance matrix is estimated. This test is known as the "tau test." The tau test will be severely compromised if the lag at which the analysis is performed is approximately half the period of an internal oscillation frequency. In this case, the tau test will fail even though the dynamics are actually linear. Thus, until now, the tau test has only been possible for lags smaller than this "Nyquist lag." In this poster, we investigate the use of Hilbert transforms as a way to avoid the problems associated with Nyquist lags. By augmenting the data with dimensions orthogonal to those spanning the original system, information that would be inaccessible to LIM in its original form may be sampled.

GRB 050717: A Long, Short-Lag Burst Observed by Swift and Konus

NASA Technical Reports Server (NTRS)

Krimm, H. A.; Hurkett, C.; Pal'shin, V.; Norris, J. P.; Zhang, B.; Barthelmy, S. D.; Burrows, D. N.; Gehrels, N.; Golenetskii, S.; Osborne, J. P.;

The Weighted-Average Lagged Ensemble.

PubMed

DelSole, T; Trenary, L; Tippett, M K

2017-11-01

A lagged ensemble is an ensemble of forecasts from the same model initialized at different times but verifying at the same time. The skill of a lagged ensemble mean can be improved by assigning weights to different forecasts in such a way as to maximize skill. If the forecasts are bias corrected, then an unbiased weighted lagged ensemble requires the weights to sum to one. Such a scheme is called a weighted-average lagged ensemble. In the limit of uncorrelated errors, the optimal weights are positive and decay monotonically with lead time, so that the least skillful forecasts have the least weight. In more realistic applications, the optimal weights do not always behave this way. This paper presents a series of analytic examples designed to illuminate conditions under which the weights of an optimal weighted-average lagged ensemble become negative or depend nonmonotonically on lead time. It is shown that negative weights are most likely to occur when the errors grow rapidly and are highly correlated across lead time. The weights are most likely to behave nonmonotonically when the mean square error is approximately constant over the range forecasts included in the lagged ensemble. An extreme example of the latter behavior is presented in which the optimal weights vanish everywhere except at the shortest and longest lead times.

47 CFR 52.103 - Lag times.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

47 CFR 52.103 - Lag times.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 3 2012-10-01 2012-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

47 CFR 52.103 - Lag times.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 3 2011-10-01 2011-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

47 CFR 52.103 - Lag times.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 3 2013-10-01 2013-10-01 false Lag times. 52.103 Section 52.103... Free Numbers § 52.103 Lag times. (a) Definitions. As used in this section, the following definitions... and an exchange carrier intercept recording is being provided. (3) Lag Time. The interval between a...

Simplifying the diagnosis of 4 common voiding conditions using uroflow/electromyography, electromyography lag time and voiding history.

PubMed

Van Batavia, Jason P; Combs, Andrew J; Hyun, Grace; Bayer, Agnes; Medina-Kreppein, Daisy; Schlussel, Richard N; Glassberg, Kenneth I

2011-10-01

Noninvasive uroflowmetry with simultaneous electromyography is useful to triage cases of lower urinary tract symptoms into 4 urodynamically defined conditions, especially when incorporating short and long electromyography lag times in the analysis. We determined the prevalence of these 4 conditions at a single referral institution and the usefulness of uroflowmetry with simultaneous electromyography and electromyography lag time to confirm the diagnosis, guide treatment and monitor response. We retrospectively reviewed the records of 100 consecutive normal children who presented with persistent lower urinary tract symptoms, underwent uroflowmetry with electromyography as part of the initial evaluation and were diagnosed with 1 of 4 conditions based on certain uroflowmetry/electromyography features. The conditions included 1) dysfunctional voiding--active pelvic floor electromyography during voiding with or without staccato flow, 2a) idiopathic detrusor overactivity disorder-A--a quiet pelvic floor during voiding and shortened lag time (less than 2 seconds), 2b) idiopathic detrusor overactivity disorder-B--a quiet pelvic floor with a normal lag time, 3) detrusor underutilization disorder--volitionally deferred voiding with expanded bladder capacity but a quiet pelvic floor, and 4) primary bladder neck dysfunction--prolonged lag time (greater than 6 seconds) and a depressed, right shifted uroflowmetry curve with a quiet pelvic floor during voiding. Treatment was tailored to the underlying condition in each patient. The group consisted of 50 males and 50 females with a mean age of 8 years (range 3 to 18). Dysfunctional voiding was more common in females (p <0.05) while idiopathic detrusor overactivity disorder-B and primary bladder neck dysfunction were more common in males (p <0.01). With treatment uroflowmetry parameters normalized for all types. Electromyography lag time increased in idiopathic detrusor overactivity disorder-A cases and decreased in primary bladder

Jet Lag Disorder

MedlinePlus

... light signal is low, the hypothalamus tells the pineal gland, a small organ situated in the brain, to ... During daylight hours, the opposite occurs, and the pineal gland produces very little melatonin. You may be able ...

Jet lag prevention

MedlinePlus

... a day to adjust to one to two time zones. So if you travel over three time zones, it will take about two days for ... decisions the first day. Once you arrive, spend time in the sun. This can help reset your internal clock.

Influence of the Tibetan Plateau snow cover on East Asian winter upper-level jet streams at daily time scale

NASA Astrophysics Data System (ADS)

Guo, W.; Li, W.; Qiu, B.; Xue, Y.

2017-12-01

The Tibetan Plateau (TP) acts as an elevated cooling source in the middle troposphere at wintertime. We here present evidence that the intraseasonal variability of the TP snow cover (TPSC) controls part of the East Asian upper-level jet stream. This study found that there is significant positive lag correlation between the East Asian (EA) upper-level westerly jet and the TPSC in winter. When the TPSC increases/decreases, the EA upper-level westerly jet enhances/weakens in the following 8 days. We performed numerical experiments to prove that the lag correlation is causal relationship by using a regional climate model. Due to the high albedo of the snow cover, the increased/decreased snow cover increases/decreases the albedo and affects the surface energy balance over the TP. The energy absorbed by the surface is reduced/increased due to increased/decreased shortwave reflects to the atmosphere. There is anomalous cooling/heating effect over the TP. Such effect leads to anomalous geopotential height (GHT) field that propagates eastward with the zonal wind to the east. The anomalous GHT reaches key region of EA upper-level westerly jet at about 6 days. The adaptive modulation of GHT gradients affects wind fields (through geostrophic balance). As a result, the EA upper-level westerly jet is enhanced (weakened). Through the above process, the TPSC eventually influences the EA upper-level westerly jet. This report reveals that the intraseasonal variability of TPSC can server as an indicator of East Asia Atmospheric circulation on short-to-medium range.

X-linked Acrogigantism (X-LAG) Syndrome: Clinical Profile and Therapeutic Responses

PubMed Central

Beckers, Albert; Lodish, Maya Beth; Trivellin, Giampaolo; Rostomyan, Liliya; Lee, Misu; Faucz, Fabio R; Yuan, Bo; Choong, Catherine S; Caberg, Jean-Hubert; Verrua, Elisa; Naves, Luciana Ansaneli; Cheetham, Tim D; Young, Jacques; Lysy, Philippe A; Petrossians, Patrick; Cotterill, Andrew; Shah, Nalini Samir; Metzger, Daniel; Castermans, Emilie; Ambrosio, Maria Rosaria; Villa, Chiara; Strebkova, Natalia; Mazerkina, Nadia; Gaillard, Stéphan; Barra, Gustavo Barcelos; Casulari, Luis Augusto; Neggers, Sebastian J.; Salvatori, Roberto; Jaffrain-Rea, Marie-Lise; Zacharin, Margaret; Santamaria, Beatriz Lecumberri; Zacharieva, Sabina; Lim, Ee Mun; Mantovani, Giovanna; Zatelli, Maria Chaira; Collins, Michael T; Bonneville, Jean-François; Quezado, Martha; Chittiboina, Prashant; Oldfield, Edward H.; Bours, Vincent; Liu, Pengfei; De Herder, Wouter; Pellegata, Natalia; Lupski, James R.; Daly, Adrian F.; Stratakis, Constantine A.

2015-01-01

X-linked acro-gigantism (X-LAG) is a new syndrome of pituitary gigantism, caused by microduplications on chromosome Xq26.3, encompassing the gene GPR101, which is highly upregulated in pituitary tumors. We conducted this study to explore the clinical, radiological and hormonal phenotype and responses to therapy in patients with X-LAG syndrome. The study included 18 patients (13 sporadic) with X-LAG and a microduplication in chromosome Xq26.3. All sporadic cases had unique duplications and the inheritance pattern in 2 families was dominant with all Xq26.3 duplication carriers being affected. Patients began to grow rapidly as early as 2–3 months of age (median 12 months). At diagnosis (median delay 27 months), patients had a median height and weight SDS score of >+3.9 SDS. Apart from the increased overall body size, the children had acromegalic symptoms including acral enlargement and facial coarsening. More than a third of cases had increased appetite. Patients had marked hypersecretion of GH/IGF-1 and prolactin, usually due to a pituitary macroadenoma or hyperplasia. Primary neurosurgical control was achieved with extensive anterior pituitary resection but postoperative hypopituitarism was frequent. Control with somatostatin analogs was not readily achieved despite moderate to high somatostatin receptor subtype-2 expression in tumor tissue. Postoperative adjuvant pegvisomant achieved control of IGF-1 all 5 cases in which it was employed. X-LAG is a new infant-onset gigantism syndrome that has a severe clinical phenotype leading to challenging disease management. PMID:25712922

Robust Short-Lag Spatial Coherence Imaging.

PubMed

Nair, Arun Asokan; Tran, Trac Duy; Bell, Muyinatu A Lediju

2018-03-01

Short-lag spatial coherence (SLSC) imaging displays the spatial coherence between backscattered ultrasound echoes instead of their signal amplitudes and is more robust to noise and clutter artifacts when compared with traditional delay-and-sum (DAS) B-mode imaging. However, SLSC imaging does not consider the content of images formed with different lags, and thus does not exploit the differences in tissue texture at each short-lag value. Our proposed method improves SLSC imaging by weighting the addition of lag values (i.e., M-weighting) and by applying robust principal component analysis (RPCA) to search for a low-dimensional subspace for projecting coherence images created with different lag values. The RPCA-based projections are considered to be denoised versions of the originals that are then weighted and added across lags to yield a final robust SLSC (R-SLSC) image. Our approach was tested on simulation, phantom, and in vivo liver data. Relative to DAS B-mode images, the mean contrast, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) improvements with R-SLSC images are 21.22 dB, 2.54, and 2.36, respectively, when averaged over simulated, phantom, and in vivo data and over all lags considered, which corresponds to mean improvements of 96.4%, 121.2%, and 120.5%, respectively. When compared with SLSC images, the corresponding mean improvements with R-SLSC images were 7.38 dB, 1.52, and 1.30, respectively (i.e., mean improvements of 14.5%, 50.5%, and 43.2%, respectively). Results show great promise for smoothing out the tissue texture of SLSC images and enhancing anechoic or hypoechoic target visibility at higher lag values, which could be useful in clinical tasks such as breast cyst visualization, liver vessel tracking, and obese patient imaging.

How are parent–child conflict and childhood externalizing symptoms related over time? Results from a genetically informative cross-lagged study

PubMed Central

BURT, S. ALEXANDRA; McGUE, MATT; KRUEGER, ROBERT F.; IACONO, WILLIAM G.

2008-01-01

The present study attempted to determine the direction and etiology of the robust relationship between childhood externalizing (EXT) symptoms and parent–child conflict using a genetically informative longitudinal model and data from the ongoing Minnesota Twin Family Study. Participants consisted of 1,506 same-sex twins assessed at ages 11 and 14, and their parents. The relationship between EXT and parent–child conflict from ages 11 to 14 was examined within a biometrical cross-lagged design. The results revealed three primary findings: first, the stability of conflict and externalizing over time is largely, although not solely, a result of genetic factors. Second, there appears to be a bidirectional relationship between conflict and EXT over time, such that both conflict and EXT at 11 independently predict the other 3 years later. Finally, the results are consistent with the notion that parent–child conflict partially results from parental responses to their child’s heritable externalizing behavior, while simultaneously contributing to child externalizing via environmental mechanisms. These results suggest a “downward spiral” of interplay between parent–child conflict and EXT, and offer confirmation of a (partially) environmentally mediated effect of parenting on child behavior. PMID:15971764

Marital satisfaction and maternal depressive symptoms among Korean mothers transitioning to parenthood.

PubMed

Choi, Eunsil

2016-06-01

Although many empirical findings support associations between marital satisfaction and depressive symptoms, gaps remain in our understanding of the magnitude and direction of the associations between marital satisfaction and depressive symptoms as well as the associations in a collectivistic culture. The present study examined autoregressive cross-lagged associations between marital satisfaction and maternal depressive symptoms across a 3-year investigation in a sample of Korean mothers transitioning to parenthood. The sample consisted of 2,078 mothers in the Panel Study of Korean Children. The mothers reported marital satisfaction and maternal depressive symptoms annually for 3 years. The results of an autoregressive cross-lagged model revealed bidirectional associations between marital satisfaction and maternal depressive symptoms. The findings provide evidence of an interactional model of depression in a sample of Korean mothers. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

A cross-lagged model of the reciprocal associations of loneliness and memory functioning.

PubMed

Ayalon, Liat; Shiovitz-Ezra, Sharon; Roziner, Ilan

2016-05-01

The study was designed to evaluate the reciprocal associations of loneliness and memory functioning using a cross-lagged model. The study was based on the psychosocial questionnaire of the Health and Retirement Study, which is a U.S. nationally representative survey of individuals over the age of 50 and their spouses of any age. A total of 1,225 respondents had complete data on the loneliness measure in 2004 and at least in 1 of the subsequent waves (e.g., 2008, 2012) and were maintained for analysis. A cross-lagged model was estimated to examine the reciprocal associations of loneliness and memory functioning, controlling for age, gender, education, depressive symptoms, number of medical conditions, and the number of close social relationships. The model had adequate fit indices: χ2(860, N = 1,225) = 1,401.54, p < .001, Tucker-Lewis index = .957, comparative fit index = .963, and root mean square error of approximation = .023 (90% confidence interval [.021, .025]). The lagged effect of loneliness on memory functioning was nonsignificant, B(SE) = -.11(.08), p = .15, whereas the lagged effect of memory functioning on loneliness was significant, B(SE) = -.06(.02), p = .01, indicating that lower levels of memory functioning precede higher levels of loneliness 4 years afterward. Further research is required to better understand the mechanisms responsible for the temporal association between reduced memory functioning and increased loneliness. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

In first-time mothers, post-partum depressive symptom prospectively predict symptoms of post-traumatic stress.

PubMed

Shahar, Golan; Herishanu-Gilutz, Shirley; Holcberg, Gershon; Kofman, Ora

2015-11-01

Symptoms of both depression and Post-Traumatic Stress Disorder (PTSD) are prevalent among first-time mothers following birth. However, the direction of the association between the two types of symptoms is unclear. Ninety six first-time mothers giving birth via vaginal delivery (N=38), emergency C-Section (N=27) and planned C-Section (N=21) were assessed for depression and PTSD twice: Six weeks post-partum and six-weeks later. Cross-lagged Structural Equation Modeling (SEM) analyses revealed a prospective effect of depressive symptoms on PTSD symptoms. No moderating factors were identified. A relatively modest sample size and only two assessment waves. An early detection and intervention with symptoms of post-partum depression might also prevent the development of PTSD symptoms. Copyright © 2015 Elsevier B.V. All rights reserved.

Acute mountain sickness: Is there a lag period before symptoms?

PubMed

Gonzales, Gustavo F; Villena, Arturo; Aparicio, Ramon

1998-01-01

The present study was designed to determine if symptoms of acute mountain sickness are presented within six hours after arrival at high altitude. Seventeen male subjects, 23-30 years, were studied. The subjects were professional soccer players, life-long residents at low altitudes except one player who was playing soccer in a team at 3400 m (512 mm Hg of Barometric Pressure) during an entire year in 1995. The players were transported by a commercial airline from Lima (150 m) to Cusco (3400 m). The trip lasted 1 hour. Heart rate and arterial oxygen saturation were measured at rest in Lima (150 m), at the time of arrival at Cusco, and at 4 and 6 hours after arrival at 3400 m. On day 6 at high altitude, the physical performance during a soccer game was assessed. The symptoms of acute mountain sickness (AMS) were assessed 6 hours after arrival at Cusco with a self-administered questionnaire, and thereafter each 24-hours up to 5 days of exposure to high altitude. The following symptoms were assessed: headache, gastrointestinal symptoms, dizziness, fatigue, and sleep abnormalities. AMS was defined by a Lake-Louise score ⩾4 (self-assessment only). Thirty five percent of the soccer players developed AMS within 6 hours after arrival by air at 3400 m altitude. Arterial oxygen saturation at arrival was higher in those player who developed AMS within 6 hours after arrival (94.3 ± 0.94% vs 90.8 ± 2.36; P < 0.001). From arrival to 6 hours of exposure to altitude, there was a significant fall in arterial oxygen saturation in those men who developed AMS than in those who did not. Results from the stepwise multiple regression (R 2 = 0.59; P < 0.04) and logistic regression (R 2 = 0.48; P < 0.0019) analyses showed that the difference between arterial oxygen saturation at sea level and at arrival at Cusco was a predictor for the development of AMS within 6 hours upon arrival at altitude. This suggests that the lower the difference between arterial oxygen saturation at sea level

Emotion regulation predicts symptoms of depression over five years.

PubMed

Berking, Matthias; Wirtz, Carolin M; Svaldi, Jennifer; Hofmann, Stefan G

2014-06-01

Deficits in emotion regulation have been identified as an important risk and maintaining factor for depression. The aim of this study was to examine the long-term effects of emotion regulation on symptoms of depression. Moreover, we investigated which specific emotion regulation skills were associated with subsequent symptoms of depression. Participants were 116 individuals (78% women, average age 35.2 years) who registered for an online-based assessment of depression and its risk-factors and reported at least some symptoms of depression. Successful application of emotion regulation skills and depressive symptom severity were assessed twice over a 5-year period. We utilized cross-lagged panel analyses to assess whether successful skills application would be negatively associated with subsequent depressive symptom severity. Cross-lagged panel analyses identified successful skills application as a significant predictor for depressive symptom severity even when controlling for the effects of initial symptoms of depression. A comparison of the effect sizes for different emotion regulation skills on subsequent depressive symptoms suggests that most of the skills included have similar predictive value. These findings provide preliminary evidence for the hypotheses that deficits in emotion regulation may contribute to the development of depression and that interventions systematically enhancing adaptive emotion regulation skills may help prevent and treat depressive symptoms. Copyright © 2014 Elsevier Ltd. All rights reserved.

Repetition and lag effects in movement recognition.

PubMed

Hall, C R; Buckolz, E

1982-03-01

Whether repetition and lag improve the recognition of movement patterns was investigated. Recognition memory was tested for one repetition, two-repetitions massed, and two-repetitions distributed with movement patterns at lags of 3, 5, 7, and 13. Recognition performance was examined both immediately afterwards and following a 48 hour delay. Both repetition and lag effects failed to be demonstrated, providing some support for the claim that memory is unaffected by repetition at a constant level of processing (Craik & Lockhart, 1972). There was, as expected, a significant decrease in recognition memory following the retention interval, but this appeared unrelated to repetition or lag.

Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study.

PubMed

Cacioppo, John T; Hawkley, Louise C; Thisted, Ronald A

2010-06-01

We present evidence from a 5-year longitudinal study for the prospective associations between loneliness and depressive symptoms in a population-based, ethnically diverse sample of 229 men and women who were 50-68 years old at study onset. Cross-lagged panel models were used in which the criterion variables were loneliness and depressive symptoms, considered simultaneously. We used variations on this model to evaluate the possible effects of gender, ethnicity, education, physical functioning, medications, social network size, neuroticism, stressful life events, perceived stress, and social support on the observed associations between loneliness and depressive symptoms. Cross-lagged analyses indicated that loneliness predicted subsequent changes in depressive symptomatology, but not vice versa, and that this temporal association was not attributable to demographic variables, objective social isolation, dispositional negativity, stress, or social support. The importance of distinguishing between loneliness and depressive symptoms and the implications for loneliness and depressive symptomatology in older adults are discussed. (c) 2010 APA, all rights reserved

Organizational justice and health: Studying mental preoccupation with work and social support as mediators for lagged and reversed relationships.

PubMed

Eib, Constanze; Bernhard-Oettel, Claudia; Magnusson Hanson, Linda L; Leineweber, Constanze

2018-03-05

Organizational justice perceptions are considered a predictor of health and well-being. To date, empirical evidence about whether organizational justice perceptions predict health or health predicts organizational justice perceptions is mixed. Furthermore, the processes underlying these relationships are largely unknown. In this article, we study whether bidirectional relationships can be explained by 2 different mediation mechanisms. First, based on the allostatic load model, we suggest that the relationships between organizational justice perceptions and different health indicators are mediated through mental preoccupation with work. Second, based on the affective perception and affective reaction assumption, we investigate if the relationships between different health indicators and organizational justice perceptions are mediated by social support at work. Using a large-scale Swedish panel study (N = 3,236), we test the bidirectional mediating relationships between procedural justice perceptions and self-rated health, depressive symptoms, and sickness absence with a cross-lagged design with 3 waves of data. Significant lagged effects from procedural justice to health were found for models predicting depressive symptoms and sickness absence. Mental preoccupation with work was not found to mediate the longitudinal relationship between procedural justice perceptions and indicators of health. Significant lagged effects from health indicators to procedural justice were found for models involving self-rated health, depressive symptoms, and sickness absence. Social support mediated the longitudinal relationships between all 3 health indicators and procedural justice. Results are discussed in light of previous studies and implications for theory and practice are outlined. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Spectral lags in different episodes of gamma-ray bursts

NASA Astrophysics Data System (ADS)

Jia, LanWei; Yi, TingFeng; Liang, EnWei

2013-08-01

A systematical analysis of the spectral lags in different episodes within a gamma-ray burst (GRB) for the BATSE GRB sample is given. The identified episodes are usually a single pulse with mixing of small fluctuations. The spectral lags were calculated for lightcurves in the 25-55 keV and 110-320 keV bands. No universal spectral lag evolution feature in different episodes within a GRB were found for most GRBs. Among 362 bright GRBs that have at least three well-identified episodes, 19 of them show long-to-short lag and 19 of them show short-to-long lag in successive episodes. The other 324 GRBs have no clear evolution trend. Defining the specified lag with the ratio of the spectral lag to the episode duration in 110-320 keV band, no prominent case of specified lag was found showing clear evolution features. The results suggest that the observed spectral lag may contribute to the dynamics and/or the radiation physics of a given emission episode.

Vicious circle of perceived stigma, enacted stigma and depressive symptoms among children affected by HIV/AIDS in China.

PubMed

Chi, Peilian; Li, Xiaoming; Zhao, Junfeng; Zhao, Guoxiang

2014-06-01

Previous research has found a deleterious impact of stigma on the mental health of children affected by HIV/AIDS. Little is known about the longitudinal relationship of stigma and children's mental health. This study explores the longitudinal reciprocal effects of depressive symptoms and stigma, specifically enacted stigma and perceived stigma, among children affected by HIV/AIDS aged 6-12. Longitudinal data were collected from 272 children orphaned by AIDS and 249 children of HIV-positive parents in rural China. Cross-lagged panel analysis was conducted in the study. Results showed that the autoregressive effects were stable for depressive symptoms, perceived stigma and enacted stigma suggesting the substantially stable individual differences over time. The cross-lagged effects indicated a vicious circle among the three variables in an order of enacted stigma → depressive symptom → perceived stigma → enacted stigma. The possibility of employing equal constraints on cross-lagged paths suggested that the cross-lagged effects were repeatable over time. The dynamic interplay of enacted stigma, perceived stigma and depressive symptoms suggests the need of a multilevel intervention in stigma reduction programming to promote mental health of children affected by HIV/AIDS.

Statistical properties of Fourier-based time-lag estimates

NASA Astrophysics Data System (ADS)

Epitropakis, A.; Papadakis, I. E.

2016-06-01

Context. The study of X-ray time-lag spectra in active galactic nuclei (AGN) is currently an active research area, since it has the potential to illuminate the physics and geometry of the innermost region (I.e. close to the putative super-massive black hole) in these objects. To obtain reliable information from these studies, the statistical properties of time-lags estimated from data must be known as accurately as possible. Aims: We investigated the statistical properties of Fourier-based time-lag estimates (I.e. based on the cross-periodogram), using evenly sampled time series with no missing points. Our aim is to provide practical "guidelines" on estimating time-lags that are minimally biased (I.e. whose mean is close to their intrinsic value) and have known errors. Methods: Our investigation is based on both analytical work and extensive numerical simulations. The latter consisted of generating artificial time series with various signal-to-noise ratios and sampling patterns/durations similar to those offered by AGN observations with present and past X-ray satellites. We also considered a range of different model time-lag spectra commonly assumed in X-ray analyses of compact accreting systems. Results: Discrete sampling, binning and finite light curve duration cause the mean of the time-lag estimates to have a smaller magnitude than their intrinsic values. Smoothing (I.e. binning over consecutive frequencies) of the cross-periodogram can add extra bias at low frequencies. The use of light curves with low signal-to-noise ratio reduces the intrinsic coherence, and can introduce a bias to the sample coherence, time-lag estimates, and their predicted error. Conclusions: Our results have direct implications for X-ray time-lag studies in AGN, but can also be applied to similar studies in other research fields. We find that: a) time-lags should be estimated at frequencies lower than ≈ 1/2 the Nyquist frequency to minimise the effects of discrete binning of the

46 CFR 36.30-1 - Lagged tanks-TB/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

46 CFR 36.30-1 - Lagged tanks-TB/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

46 CFR 36.30-1 - Lagged tanks-TB/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

46 CFR 36.30-1 - Lagged tanks-TB/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

46 CFR 36.30-1 - Lagged tanks-TB/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Lagged tanks-TB/ALL. 36.30-1 Section 36.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS ELEVATED TEMPERATURE CARGOES Periodic Inspections § 36.30-1 Lagged tanks—TB/ALL. (a) Lagged tanks shall have part of the lagging removed on the...

Change in obsessive-compulsive symptoms mediates subsequent change in depressive symptoms during exposure and response prevention.

PubMed

Zandberg, Laurie J; Zang, Yinyin; McLean, Carmen P; Yeh, Rebecca; Simpson, Helen Blair; Foa, Edna B

2015-05-01

The current study examines the temporal relationship between changes in obsessive-compulsive symptoms and changes in depressive symptoms during exposure and response prevention (EX/RP) therapy for obsessive-compulsive disorder (OCD). Participants were 40 adults (53% female) who received EX/RP in a randomized controlled trial comparing serotonin reuptake inhibitor (SRI) augmentation strategies. Participants completed clinician-administered assessments of OCD (Yale-Brown Obsessive Compulsive Scale) and depressive symptoms (Hamilton Depression Rating Scale) every four weeks from baseline to 32-week follow-up. Lagged multilevel mediational analyses indicated that change in OCD symptoms accounted for 65% of subsequent change in depressive symptoms. In contrast, change in depressive symptoms only partially mediated subsequent change in OCD symptoms, accounting for 20% of the variance in outcome. These data indicate that reductions in co-morbid depressive symptoms during EX/RP for OCD are largely driven by reductions in obsessive-compulsive symptoms. Copyright © 2015 Elsevier Ltd. All rights reserved.

Comparing lagged linear correlation, lagged regression, Granger causality, and vector autoregression for uncovering associations in EHR data.

PubMed

Levine, Matthew E; Albers, David J; Hripcsak, George

2016-01-01

Time series analysis methods have been shown to reveal clinical and biological associations in data collected in the electronic health record. We wish to develop reliable high-throughput methods for identifying adverse drug effects that are easy to implement and produce readily interpretable results. To move toward this goal, we used univariate and multivariate lagged regression models to investigate associations between twenty pairs of drug orders and laboratory measurements. Multivariate lagged regression models exhibited higher sensitivity and specificity than univariate lagged regression in the 20 examples, and incorporating autoregressive terms for labs and drugs produced more robust signals in cases of known associations among the 20 example pairings. Moreover, including inpatient admission terms in the model attenuated the signals for some cases of unlikely associations, demonstrating how multivariate lagged regression models' explicit handling of context-based variables can provide a simple way to probe for health-care processes that confound analyses of EHR data.

Self-consistent fluid modeling and simulation on a pulsed microwave atmospheric-pressure argon plasma jet

NASA Astrophysics Data System (ADS)

Chen, Zhaoquan; Yin, Zhixiang; Chen, Minggong; Hong, Lingli; Xia, Guangqing; Hu, Yelin; Huang, Yourui; Liu, Minghai; Kudryavtsev, A. A.

2014-10-01

In present study, a pulsed lower-power microwave-driven atmospheric-pressure argon plasma jet has been introduced with the type of coaxial transmission line resonator. The plasma jet plume is with room air temperature, even can be directly touched by human body without any hot harm. In order to study ionization process of the proposed plasma jet, a self-consistent hybrid fluid model is constructed in which Maxwell's equations are solved numerically by finite-difference time-domain method and a fluid model is used to study the characteristics of argon plasma evolution. With a Guass type input power function, the spatio-temporal distributions of the electron density, the electron temperature, the electric field, and the absorbed power density have been simulated, respectively. The simulation results suggest that the peak values of the electron temperature and the electric field are synchronous with the input pulsed microwave power but the maximum quantities of the electron density and the absorbed power density are lagged to the microwave power excitation. In addition, the pulsed plasma jet excited by the local enhanced electric field of surface plasmon polaritons should be the discharge mechanism of the proposed plasma jet.

Dichotomy of Solar Coronal Jets: Standard Jets and Blowout Jets

NASA Technical Reports Server (NTRS)

Moore, R. L.; Cirtain, J. W.; Sterling, A. C.; Falconer, D. A.

2010-01-01

By examining many X-ray jets in Hinode/XRT coronal X-ray movies of the polar coronal holes, we found that there is a dichotomy of polar X-ray jets. About two thirds fit the standard reconnection picture for coronal jets, and about one third are another type. We present observations indicating that the non-standard jets are counterparts of erupting-loop H alpha macrospicules, jets in which the jet-base magnetic arch undergoes a miniature version of the blowout eruptions that produce major CMEs. From the coronal X-ray movies we present in detail two typical standard X-ray jets and two typical blowout X-ray jets that were also caught in He II 304 Angstrom snapshots from STEREO/EUVI. The distinguishing features of blowout X-ray jets are (1) X-ray brightening inside the base arch in addition to the outside bright point that standard jets have, (2) blowout eruption of the base arch's core field, often carrying a filament of cool (T 10(exp 4) - 10(exp 5) K) plasma, and (3) an extra jet-spire strand rooted close to the bright point. We present cartoons showing how reconnection during blowout eruption of the base arch could produce the observed features of blowout X-ray jets. We infer that (1) the standard-jet/blowout-jet dichotomy of coronal jets results from the dichotomy of base arches that do not have and base arches that do have enough shear and twist to erupt open, and (2) there is a large class of spicules that are standard jets and a comparably large class of spicules that are blowout jets.

Bilateral Vestibular Dysfunction Associated With Chronic Exposure to Military Jet Propellant Type-Eight Jet Fuel

PubMed Central

Fife, Terry D.; Robb, Michael J. A.; Steenerson, Kristen K.; Saha, Kamala C.

2018-01-01

We describe three patients diagnosed with bilateral vestibular dysfunction associated with the jet propellant type-eight (JP-8) fuel exposure. Chronic exposure to aromatic and aliphatic hydrocarbons, which are the main constituents of JP-8 military aircraft jet fuel, occurred over 3–5 years’ duration while working on or near the flight line. Exposure to toxic hydrocarbons was substantiated by the presence of JP-8 metabolite n-hexane in the blood of one of the cases. The presenting symptoms were dizziness, headache, fatigue, and imbalance. Rotational chair testing confirmed bilateral vestibular dysfunction in all the three patients. Vestibular function improved over time once the exposure was removed. Bilateral vestibular dysfunction has been associated with hydrocarbon exposure in humans, but only recently has emphasis been placed specifically on the detrimental effects of JP-8 jet fuel and its numerous hydrocarbon constituents. Data are limited on the mechanism of JP-8-induced vestibular dysfunction or ototoxicity. Early recognition of JP-8 toxicity risk, cessation of exposure, and customized vestibular therapy offer the best chance for improved balance. Bilateral vestibular impairment is under-recognized in those chronically exposed to all forms of jet fuel. PMID:29867750

Bilateral Vestibular Dysfunction Associated With Chronic Exposure to Military Jet Propellant Type-Eight Jet Fuel.

PubMed

Fife, Terry D; Robb, Michael J A; Steenerson, Kristen K; Saha, Kamala C

2018-01-01

We describe three patients diagnosed with bilateral vestibular dysfunction associated with the jet propellant type-eight (JP-8) fuel exposure. Chronic exposure to aromatic and aliphatic hydrocarbons, which are the main constituents of JP-8 military aircraft jet fuel, occurred over 3-5 years' duration while working on or near the flight line. Exposure to toxic hydrocarbons was substantiated by the presence of JP-8 metabolite n -hexane in the blood of one of the cases. The presenting symptoms were dizziness, headache, fatigue, and imbalance. Rotational chair testing confirmed bilateral vestibular dysfunction in all the three patients. Vestibular function improved over time once the exposure was removed. Bilateral vestibular dysfunction has been associated with hydrocarbon exposure in humans, but only recently has emphasis been placed specifically on the detrimental effects of JP-8 jet fuel and its numerous hydrocarbon constituents. Data are limited on the mechanism of JP-8-induced vestibular dysfunction or ototoxicity. Early recognition of JP-8 toxicity risk, cessation of exposure, and customized vestibular therapy offer the best chance for improved balance. Bilateral vestibular impairment is under-recognized in those chronically exposed to all forms of jet fuel.

LAG3 Expression in Active Mycobacterium tuberculosis Infections

PubMed Central

Phillips, Bonnie L.; Mehra, Smriti; Ahsan, Muhammad H.; Selman, Moises; Khader, Shabaana A.; Kaushal, Deepak

2016-01-01

Mycobacterium tuberculosis (MTB) is a highly successful pathogen because of its ability to persist in human lungs for long periods of time. MTB modulates several aspects of the host immune response. Lymphocyte-activation gene 3 (LAG3) is a protein with a high affinity for the CD4 receptor and is expressed mainly by regulatory T cells with immunomodulatory functions. To understand the function of LAG3 during MTB infection, a nonhuman primate model of tuberculosis, which recapitulates key aspects of natural human infection in rhesus macaques (Macaca mulatta), was used. We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with MTB. Furthermore, we show that LAG3 expression is not induced in the lungs and lung granulomas of animals exhibiting latent tuberculosis infection. However, simian immunodeficiency virus–induced reactivation of latent tuberculosis infection results in an increased expression of LAG3 in the lungs. This response is not observed in nonhuman primates infected with non-MTB bacterial pathogens, nor with simian immunodeficiency virus alone. Our data show that LAG3 was expressed primarily on CD4+ T cells, presumably by regulatory T cells but also by natural killer cells. The expression of LAG3 coincides with high bacterial burdens and changes in the host type 1 helper T-cell response. PMID:25549835

Behavioral Processes in Long-Lag Intervention Studies.

PubMed

Miller, Dale T; Dannals, Jennifer E; Zlatev, Julian J

2017-05-01

We argue that psychologists who conduct experiments with long lags between the manipulation and the outcome measure should pay more attention to behavioral processes that intervene between the manipulation and the outcome measure. Neglect of such processes, we contend, stems from psychology's long tradition of short-lag lab experiments where there is little scope for intervening behavioral processes. Studying process in the lab invariably involves studying psychological processes, but in long-lag field experiments it is important to study causally relevant behavioral processes as well as psychological ones. To illustrate the roles that behavioral processes can play in long-lag experiments we examine field experiments motivated by three policy-relevant goals: prejudice reduction, health promotion, and educational achievement. In each of the experiments discussed we identify various behavioral pathways through which the manipulated psychological state could have produced the observed outcome. We argue that if psychologists conducting long-lag interventions posited a theory of change that linked manipulated psychological states to outcomes via behavioral pathways, the result would be richer theory and more practically useful research. Movement in this direction would also permit more opportunities for productive collaborations between psychologists and other social scientists interested in similar social problems.

DICHOTOMY OF SOLAR CORONAL JETS: STANDARD JETS AND BLOWOUT JETS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, Ronald L.; Cirtain, Jonathan W.; Sterling, Alphonse C.

2010-09-01

By examining many X-ray jets in Hinode/X-Ray Telescope coronal X-ray movies of the polar coronal holes, we found that there is a dichotomy of polar X-ray jets. About two thirds fit the standard reconnection picture for coronal jets, and about one third are another type. We present observations indicating that the non-standard jets are counterparts of erupting-loop H{alpha} macrospicules, jets in which the jet-base magnetic arch undergoes a miniature version of the blowout eruptions that produce major coronal mass ejections. From the coronal X-ray movies we present in detail two typical standard X-ray jets and two typical blowout X-ray jetsmore » that were also caught in He II 304 A snapshots from STEREO/EUVI. The distinguishing features of blowout X-ray jets are (1) X-ray brightening inside the base arch in addition to the outside bright point that standard jets have, (2) blowout eruption of the base arch's core field, often carrying a filament of cool (T {approx} 10{sup 4} - 10{sup 5} K) plasma, and (3) an extra jet-spire strand rooted close to the bright point. We present cartoons showing how reconnection during blowout eruption of the base arch could produce the observed features of blowout X-ray jets. We infer that (1) the standard-jet/blowout-jet dichotomy of coronal jets results from the dichotomy of base arches that do not have and base arches that do have enough shear and twist to erupt open, and (2) there is a large class of spicules that are standard jets and a comparably large class of spicules that are blowout jets.« less

Longitudinal Associations Among Pain, Posttraumatic Stress Disorder Symptoms, and Stress Appraisals.

PubMed

Vaughan, Christine A; Miles, Jeremy N V; Eisenman, David P; Meredith, Lisa S

2016-04-01

Comorbidity of posttraumatic stress disorder (PTSD) and pain is well documented, but the mechanisms underlying their comorbidity are not well understood. Cross-lagged regression models were estimated with 3 waves of longitudinal data to examine the reciprocal associations between PTSD symptom severity, as measured by the Clinician-Administered PTSD Scale (CAPS), and pain, as measured by a brief self-report measure of pain called the PEG (pain intensity [P], interference with enjoyment of life [E], and interference with general activity [G]). We evaluated stress appraisals as a mediator of these associations in a sample of low-income, underserved patients with PTSD (N = 355) at federally qualified health centers in a northeastern metropolitan area. Increases in PTSD symptom severity between baseline and 6-month and 6- and 12-month assessments were independently predicted by higher levels of pain (β = .14 for both lags) and appraisals of life stress as uncontrollable (β = .15 for both lags). Stress appraisals, however, did not mediate these associations, and PTSD symptom severity did not predict change in pain. Thus, the results did not support the role of stress appraisals as a mechanism underlying the associations between pain and PTSD. Copyright © 2016 International Society for Traumatic Stress Studies.

X-ray time lags in PG 1211+143

NASA Astrophysics Data System (ADS)

Lobban, A. P.; Vaughan, S.; Pounds, K.; Reeves, J. N.

2018-05-01

We investigate the X-ray time lags of a recent ˜630 ks XMM-Newton observation of PG 1211+143. We find well-correlated variations across the XMM-Newton EPIC bandpass, with the first detection of a hard lag in this source with a mean time delay of up to ˜3 ks at the lowest frequencies. We find that the energy-dependence of the low-frequency hard lag scales approximately linearly with log(E) when averaged over all orbits, consistent with the propagating fluctuations model. However, we find that the low-frequency lag behaviour becomes more complex on time-scales longer than a single orbit, suggestive of additional modes of variability. We also detect a high-frequency soft lag at ˜10-4 Hz with the magnitude of the delay peaking at ≲ 0.8 ks, consistent with previous observations, which we discuss in terms of small-scale reverberation.

Jet in jet in M87

NASA Astrophysics Data System (ADS)

Sob'yanin, Denis Nikolaevich

2017-11-01

New high-resolution Very Long Baseline Interferometer observations of the prominent jet in the M87 radio galaxy show a persistent triple-ridge structure of the transverse 15-GHz profile with a previously unobserved ultra-narrow central ridge. This radio structure can reflect the intrinsic structure of the jet, so that the jet as a whole consists of two embedded coaxial jets. A relativistic magnetohydrodynamic model is considered in which an inner jet is placed inside a hollow outer jet and the electromagnetic fields, pressures and other physical quantities are found. The entire jet is connected to the central engine that plays the role of a unipolar inductor generating voltage between the jets and providing opposite electric currents, and the charge neutrality and current closure together with the electromagnetic fields between the jets can contribute to the jet stabilization. The constant voltage is responsible for the similar widening laws observed for the inner and outer jets. This jet-in-jet structure can indicate simultaneous operation of two different jet-launching mechanisms, one relating to the central supermassive black hole and the other to the surrounding accretion disc. An inferred magnetic field of 80 G at the base is sufficient to provide the observed jet luminosity.

LAG3 expression in active Mycobacterium tuberculosis infections.

PubMed

Phillips, Bonnie L; Mehra, Smriti; Ahsan, Muhammad H; Selman, Moises; Khader, Shabaana A; Kaushal, Deepak

2015-03-01

Mycobacterium tuberculosis (MTB) is a highly successful pathogen because of its ability to persist in human lungs for long periods of time. MTB modulates several aspects of the host immune response. Lymphocyte-activation gene 3 (LAG3) is a protein with a high affinity for the CD4 receptor and is expressed mainly by regulatory T cells with immunomodulatory functions. To understand the function of LAG3 during MTB infection, a nonhuman primate model of tuberculosis, which recapitulates key aspects of natural human infection in rhesus macaques (Macaca mulatta), was used. We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with MTB. Furthermore, we show that LAG3 expression is not induced in the lungs and lung granulomas of animals exhibiting latent tuberculosis infection. However, simian immunodeficiency virus-induced reactivation of latent tuberculosis infection results in an increased expression of LAG3 in the lungs. This response is not observed in nonhuman primates infected with non-MTB bacterial pathogens, nor with simian immunodeficiency virus alone. Our data show that LAG3 was expressed primarily on CD4(+) T cells, presumably by regulatory T cells but also by natural killer cells. The expression of LAG3 coincides with high bacterial burdens and changes in the host type 1 helper T-cell response. Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

In-flight hypoxia events in tactical jet aviation: characteristics compared to normobaric training.

PubMed

Deussing, Eric C; Artino, Anthony R; Folga, Richard V

2011-08-01

Hypoxia continues to be a significant threat in military aviation. In an attempt to counter the hypoxia threat, military jet aviators receive periodic training using a reduced oxygen breathing device (ROBD). This study explored the characteristics of in-flight hypoxia events among tactical jet aviators and compared reported symptoms to those experienced during ROBD training. An anonymous survey was administered to naval aviators prior to aviation physiology training. The survey queried them about previous in-flight hypoxia encounters and the symptoms they experienced. These data were then compared to symptom data from a previous ROBD training survey using Chi-square analyses. Of the 566 aviators who completed the survey, 112 (20%) reported experiencing hypoxia symptoms in a tactical jet aircraft and 64 aviators (57%) indicated they were not wearing the required oxygen mask when the incident first occurred. The results also revealed only 21% of hypoxia events were reported in aviation hazard reports and the three most commonly recorded in-flight hypoxia symptoms were tingling (54%), difficulty concentrating (32%), and dizziness (30%). Chi-square analyses revealed statistically significant differences in frequency of reporting between 5 of 16 symptoms encountered in flight compared to ROBD training. The present investigation is the first survey-based study of hypoxia events in U.S. naval aviation. The study reveals in-flight, mask-on hypoxia has a similar overall reported symptom profile to ROBD training. Further, results suggest increased oxygen-mask compliance among these aviators may be necessary to effectively combat in-flight hypoxia.

A prospective study of the trajectories of clinical insight, affective symptoms, and cognitive ability in bipolar disorder

PubMed Central

Depp, Colin A.; Harmell, Alexandrea L.; Savla, Gauri N.; Mausbach, Brent T.; Jeste, Dilip V.; Palmer, Barton W.

2014-01-01

Background Clinical insight in bipolar disorder is associated with treatment adherence and psychosocial outcome. The short-term dynamics of clinical insight in relationship to symptoms and cognitive abilities are unknown. Methods In a prospective observational study, a total of 106 outpatients with bipolar disorder I or II were assessed at baseline, 6 weeks, 12 weeks, and 26 weeks. Participants were administered a comprehensive neuropsychological battery, clinical ratings of manic and depressive symptom severity, and self-reported clinical insight. Lagged correlations and linear mixed-effects models were used to determine the temporal associations between symptoms and insight, as well as the moderating influence of global cognitive abilities. Results At baseline, insight was modestly correlated with severity of manic symptoms, but not with depressive symptoms or cognitive abilities. Insight and depressive symptoms fluctuated to approximately the same extent over time. Both lagged correlations and mixed effects models with lagged effects indicated that the severity of manic symptoms predicted worse insight at later assessments, whereas the converse was not significant. There were no direct or moderating influences of global cognitive abilities. Limitations Our sample size was modest, and included relatively psychiatrically stable outpatients, followed for a six month period. Our results may not generalize to acutely symptomatic patients followed over a longer period. Conclusions Clinical insight varies substantially over time within patients with bipolar disorder. Impaired insight in bipolar disorder is more likely to follow than to precede manic symptoms. PMID:24200153

Spacing and lag effects in free recall of pure lists.

PubMed

Kahana, Michael J; Howard, Marc W

2005-02-01

Repeating list items leads to better recall when the repetitions are separated by several unique items than when they are presented successively; the spacing effect refers to improved recall for spaced versus successive repetition (lag > 0 vs. lag = 0); the lag effect refers to improved recall for long lags versus short lags. Previous demonstrations of the lag effect have utilized lists containing a mixture of items with varying degrees of spacing. Because differential rehearsal of items in mixed lists may exaggerate any effects of spacing, it is important to demonstrate these effects in pure lists. As in Toppino and Schneider (1999), we found an overall advantage for recall of spaced lists. We further report the first demonstration of a lag effect in pure lists, with significantly better recall for lists with widely spaced repetitions than for those with moderately spaced repetitions.

Vicious Circle of Perceived Stigma, Enacted Stigma and Depressive Symptoms among Children affected by HIV/AIDS in China

PubMed Central

Chi, Peilian; Li, Xiaoming; Zhao, Junfeng; Zhao, Guoxiang

2013-01-01

Previous research has found a deleterious impact of stigma on the mental health of children affected by HIV/AIDS. Little is known about the longitudinal relationship of stigma and children’s mental health. This study explores the longitudinal reciprocal effects of depressive symptoms and stigma, specifically enacted stigma and perceived stigma, among children affected by HIV/AIDS aged 6 to 12. Longitudinal data were collected from 272 children orphaned by AIDS and 249 children of HIV-positive parents in rural China. Cross-lagged panel analysis was conducted in the study. Results showed that the autoregressive effects were stable for depressive symptoms, perceived stigma and enacted stigma suggesting the substantially stable individual differences over time. The cross-lagged effects indicated a vicious circle among the three variables in an order of enacted stigma→depressive symptom→perceived stigma→enacted stigma. The possibility of employing equal constraints on cross-lagged paths suggested that the cross-lagged effects were repeatable over time. The dynamic interplay of enacted stigma, perceived stigma and depressive symptoms suggests the need of a multilevel intervention in stigma reduction programming to promote mental health of children affected by HIV/AIDS. PMID:24158487

Exposure-lag-response in Longitudinal Studies: Application of Distributed Lag Non-linear Models in an Occupational Cohort.

PubMed

Neophytou, Andreas M; Picciotto, Sally; Brown, Daniel M; Gallagher, Lisa E; Checkoway, Harvey; Eisen, Ellen A; Costello, Sadie

2018-02-13

Prolonged exposures can have complex relationships with health outcomes, as timing, duration, and intensity of exposure are all potentially relevant. Summary measures such as cumulative exposure or average intensity of exposure may not fully capture these relationships. We applied penalized and unpenalized distributed lag non-linear models (DLNMs) with flexible exposure-response and lag-response functions in order to examine the association between crystalline silica exposure and mortality from lung cancer and non-malignant respiratory disease in a cohort study of 2,342 California diatomaceous earth workers, followed 1942-2011. We also assessed associations using simple measures of cumulative exposure assuming linear exposure-response and constant lag-response. Measures of association from DLNMs were generally higher than from simpler models. Rate ratios from penalized DLNMs corresponding to average daily exposures of 0.4 mg/m3 during lag years 31-50 prior to the age of observed cases were 1.47 (95% confidence interval (CI) 0.92, 2.35) for lung cancer and 1.80 (95% CI: 1.14, 2.85) for non-malignant respiratory disease. Rate ratios from the simpler models for the same exposure scenario were 1.15 (95% CI: 0.89-1.48) and 1.23 (95% CI: 1.03-1.46) respectively. Longitudinal cohort studies of prolonged exposures and chronic health outcomes should explore methods allowing for flexibility and non-linearities in the exposure-lag-response. © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.

To lag or not to lag? How to compare indices of stock markets that operate on different times

NASA Astrophysics Data System (ADS)

Sandoval, Leonidas

2014-06-01

Financial markets worldwide do not have the same working hours. As a consequence, the study of correlation or causality between financial market indices becomes dependent on whether we should use all indices on the same day or lagged indices in computations of correlation matrices. The answer this article proposes is that we should consider both, by representing original and lagged indices in the same network. We then obtain a better understanding of how indices that operate on different hours relate to each other. We use a diverse range of 79 stock market indices from around the world and study their correlation structure, the eigenvalues and eigenvectors of their correlations under different time periods and volatility, as well as the differences between the working hours of the stock exchanges in order to analyze the possible time zone effects and suggest ways to remove them. We also analyze the enlarged correlation matrix obtained from original and lagged indices and examine a network structure derived from it, thus showing connections between lagged and original indices that could not be well represented before.

Why Do Rereading Lag Effects Depend on Test Delay?

ERIC Educational Resources Information Center

Rawson, Katherine A.

2012-01-01

In previous research, rereading after a long lag versus a short lag led to greater performance on delayed tests but not on immediate tests. The current study tested two accounts of why the effects of rereading lag depend on test delay. The "levels of representation" ("LOR") "hypothesis" states that the effects reflect…

A critique of the cross-lagged panel model.

PubMed

Hamaker, Ellen L; Kuiper, Rebecca M; Grasman, Raoul P P P

2015-03-01

The cross-lagged panel model (CLPM) is believed by many to overcome the problems associated with the use of cross-lagged correlations as a way to study causal influences in longitudinal panel data. The current article, however, shows that if stability of constructs is to some extent of a trait-like, time-invariant nature, the autoregressive relationships of the CLPM fail to adequately account for this. As a result, the lagged parameters that are obtained with the CLPM do not represent the actual within-person relationships over time, and this may lead to erroneous conclusions regarding the presence, predominance, and sign of causal influences. In this article we present an alternative model that separates the within-person process from stable between-person differences through the inclusion of random intercepts, and we discuss how this model is related to existing structural equation models that include cross-lagged relationships. We derive the analytical relationship between the cross-lagged parameters from the CLPM and the alternative model, and use simulations to demonstrate the spurious results that may arise when using the CLPM to analyze data that include stable, trait-like individual differences. We also present a modeling strategy to avoid this pitfall and illustrate this using an empirical data set. The implications for both existing and future cross-lagged panel research are discussed. (c) 2015 APA, all rights reserved).

An elevation of 0.1 light-seconds for the optical jet base in an accreting Galactic black hole system

NASA Astrophysics Data System (ADS)

Gandhi, P.; Bachetti, M.; Dhillon, V. S.; Fender, R. P.; Hardy, L. K.; Harrison, F. A.; Littlefair, S. P.; Malzac, J.; Markoff, S.; Marsh, T. R.; Mooley, K.; Stern, D.; Tomsick, J. A.; Walton, D. J.; Casella, P.; Vincentelli, F.; Altamirano, D.; Casares, J.; Ceccobello, C.; Charles, P. A.; Ferrigno, C.; Hynes, R. I.; Knigge, C.; Kuulkers, E.; Pahari, M.; Rahoui, F.; Russell, D. M.; Shaw, A. W.

2017-12-01

Relativistic plasma jets are observed in many systems that host accreting black holes. According to theory, coiled magnetic fields close to the black hole accelerate and collimate the plasma, leading to a jet being launched1-3. Isolating emission from this acceleration and collimation zone is key to measuring its size and understanding jet formation physics. But this is challenging because emission from the jet base cannot easily be disentangled from other accreting components. Here, we show that rapid optical flux variations from an accreting Galactic black-hole binary are delayed with respect to X-rays radiated from close to the black hole by about 0.1 seconds, and that this delayed signal appears together with a brightening radio jet. The origin of these subsecond optical variations has hitherto been controversial4-8. Not only does our work strongly support a jet origin for the optical variations but it also sets a characteristic elevation of ≲103 Schwarzschild radii for the main inner optical emission zone above the black hole9, constraining both internal shock10 and magnetohydrodynamic11 models. Similarities with blazars12,13 suggest that jet structure and launching physics could potentially be unified under mass-invariant models. Two of the best-studied jetted black-hole binaries show very similar optical lags8,14,15, so this size scale may be a defining feature of such systems.

The jet-disk symbiosis without maximal jets: 1D hydrodynamical jets revisited

NASA Astrophysics Data System (ADS)

Crumley, Patrick; Ceccobello, Chiara; Connors, Riley M. T.; Cavecchi, Yuri

2017-05-01

In this work we discuss the recent criticism by Zdziarski (2016, A&A, 586, A18) of the maximal jet model derived in Falcke & Biermann (1995, A&A, 293, 665). We agree with Zdziarski that in general a jet's internal energy is not bounded by its rest-mass energy density. We describe the effects of the mistake on conclusions that have been made using the maximal jet model and show when a maximal jet is an appropriate assumption. The maximal jet model was used to derive a 1D hydrodynamical model of jets in agnjet, a model that does multiwavelength fitting of quiescent/hard state X-ray binaries and low-luminosity active galactic nuclei. We correct algebraic mistakes made in the derivation of the 1D Euler equation and relax the maximal jet assumption. We show that the corrections cause minor differences as long as the jet has a small opening angle and a small terminal Lorentz factor. We find that the major conclusion from the maximal jet model, the jet-disk symbiosis, can be generally applied to astrophysical jets. We also show that isothermal jets are required to match the flat radio spectra seen in low-luminosity X-ray binaries and active galactic nuclei, in agreement with other works.

Recent trends for drug lag in clinical development of oncology drugs in Japan: does the oncology drug lag still exist in Japan?

PubMed

Maeda, Hideki; Kurokawa, Tatsuo

2015-12-01

This study exhaustively and historically investigated the status of drug lag for oncology drugs approved in Japan. We comprehensively investigated oncology drugs approved in Japan between April 2001 and July 2014, using publicly available information. We also examined changes in the status of drug lag between Japan and the United States, as well as factors influencing drug lag. This study included 120 applications for approval of oncology drugs in Japan. The median difference over a 13-year period in the approval date between the United States and Japan was 875 days (29.2 months). This figure peaked in 2002, and showed a tendency to decline gradually each year thereafter. In 2014, the median approval lag was 281 days (9.4 months). Multiple regression analysis identified the following potential factors that reduce drug lag: "Japan's participation in global clinical trials"; "bridging strategies"; "designation of priority review in Japan"; and "molecularly targeted drugs". From 2001 to 2014, molecularly targeted drugs emerged as the predominant oncology drug, and the method of development has changed from full development in Japan or bridging strategy to global simultaneous development by Japan's taking part in global clinical trials. In line with these changes, the drug lag between the United States and Japan has significantly reduced to less than 1 year.

Event centrality prospectively predicts PTSD symptoms.

PubMed

Boals, Adriel; Ruggero, Camilo

2016-09-01

Recent evidence suggests that event centrality has a prominent association with post-traumatic stress disorder (PTSD) symptoms. However, evidence for this notion thus far has been mostly correlational. We report two studies that prospectively examined the relationship between event centrality and PTSD symptoms. Study 1 METHODS: Participants (N = 1438) reported their most stressful event ("prior event"), along with event centrality, PTSD symptoms, and neuroticism. At Time 2 participants reported their most stressful event since Time 1 ("critical event"), along with measures of event centrality and PTSD symptoms. Study 1 RESULTS: Event centrality for the critical event predicted PTSD symptoms, after controlling for event centrality and PTSD symptoms of the prior event and neuroticism. Study In the second study (N = 161) we examined changes in event centrality and PTSD symptoms over a month. Study 2 RESULTS: Using a cross-lagged panel design, results revealed event centrality at Time 1 significantly predicted PTSD symptoms at Time 2, but the reverse was not significant. In two studies, a prospective association between event centrality and PTSD symptoms, but not the reverse, emerged. This evidence implicates event centrality in the pathogenesis and/or maintenance of PTSD symptoms.

On the phase lag of turbulent dissipation in rotating tidal flows

NASA Astrophysics Data System (ADS)

Zhang, Qianjiang; Wu, Jiaxue

2018-03-01

Field observations of rotating tidal flows in a shallow tidally swept sea reveal that a notable phase lag of both shear production and turbulent dissipation increases with height above the seafloor. These vertical delays of turbulent quantities are approximately equivalent in magnitude to that of squared mean shear. The shear production approximately equals turbulent dissipation over the phase-lag column, and thus a main mechanism of phase lag of dissipation is mean shear, rather than vertical diffusion of turbulent kinetic energy. By relating the phase lag of dissipation to that of the mean shear, a simple formulation with constant eddy viscosity is developed to describe the phase lag in rotating tidal flows. An analytical solution indicates that the phase lag increases linearly with height subjected to a combined effect of tidal frequency, Coriolis parameter and eddy viscosity. The vertical diffusion of momentum associated with eddy viscosity produces the phase lag of squared mean shear, and resultant delay of turbulent quantities. Its magnitude is inhibited by Earth's rotation. Furthermore, a theoretical formulation of the phase lag with a parabolic eddy viscosity profile can be constructed. A first-order approximation of this formulation is still a linear function of height, and its magnitude is approximately 0.8 times that with constant viscosity. Finally, the theoretical solutions of phase lag with realistic viscosity can be satisfactorily justified by realistic phase lags of dissipation.

Lag Times and Peak Coefficients for Rural Watersheds in Kansas

DOT National Transportation Integrated Search

1999-10-01

Lag time is an essential input to the most common synthetic unit-hydrograph models. The lag time for an ungaged stream must be estimated from the physical characteristics of the stream and its watershed. In this study, a lag-time formula for small ru...

Long-term exposure to jet fuel: an investigation on occupationally exposed workers with special reference to the nervous system.

PubMed

Knave, B; Persson, H E; Goldberg, J M; Westerholm, P

1976-09-01

In the present study the results of a neurological and neurophysiological health examination of 29 aircraft factory workers chronically exposed to jet fuel vapors are presented. The exposed subjects were classified into a heavily exposed and a less heavily exposed group. The examination included a standardized clinical neurological examination, measurements of the conduction velocities in the peripheral nerves, and threshold determinations of vibratory sensations in the extremities. All 13 persons examined in the heavily exposed group and 7 of the 16 in the less heavily exposed group stated that they had repeatedly experienced acute effects (dizziness, respiratory tract symptoms, heart palpitations, a feeling of pressure on the chest, nausea, headache) of the jet fuel vapors in the inhaled air. A high rate of symptoms indicative of neurasthenia and psychasthenia and symptoms and signs indicative of polyneuropathy was observed both in the heavily exposed group and in the two groups combined in comparison with reference groups. Considering the presented facts concerning (a) the acute effects on repeated occasions, (b) the high rates of symptoms indicative of neurasthenia and psychasthenia and symptoms and signs indicative of polyneuropathy, and (c) the differences in the observations made between the two groups with varying degrees of exposure to jet fuel, the authors interpreted the results as indicative of a possible effect of long-term exposure to jet fuel on the nervous system.

Mitigating shear lag in tall buildings

NASA Astrophysics Data System (ADS)

Gaur, Himanshu; Goliya, Ravindra K.

2015-09-01

As the height of building increases, effect of shear lag also becomes considerable in the design of high-rise buildings. In this paper, shear lag effect in tall buildings of heights, i.e., 120, 96, 72, 48 and 36 stories of which aspect ratio ranges from 3 to 10 is studied. Tube-in-tube structural system with façade bracing is used for designing the building of height 120 story. It is found that bracing system considerably reduces the shear lag effect and hence increases the building stiffness to withstand lateral loads. Different geometric patterns of bracing system are considered. The best effective geometric configuration of bracing system is concluded in this study. Lateral force, as wind load is applied on the buildings as it is the most dominating lateral force for such heights. Wind load is set as per Indian standard code of practice IS 875 Part-3. For analysis purpose SAP 2000 software program is used.

Twin Jet

NASA Technical Reports Server (NTRS)

Henderson, Brenda; Bozak, Rick

2010-01-01

Many subsonic and supersonic vehicles in the current fleet have multiple engines mounted near one another. Some future vehicle concepts may use innovative propulsion systems such as distributed propulsion which will result in multiple jets mounted in close proximity. Engine configurations with multiple jets have the ability to exploit jet-by-jet shielding which may significantly reduce noise. Jet-by-jet shielding is the ability of one jet to shield noise that is emitted by another jet. The sensitivity of jet-by-jet shielding to jet spacing and simulated flight stream Mach number are not well understood. The current experiment investigates the impact of jet spacing, jet operating condition, and flight stream Mach number on the noise radiated from subsonic and supersonic twin jets.

Kinetic analysis of elastomeric lag damper for helicopter rotors

NASA Astrophysics Data System (ADS)

Liu, Yafang; Wang, Jidong; Tong, Yan

2018-02-01

The elastomeric lag dampers suppress the ground resonance and air resonance that play a significant role in the stability of the helicopter. In this paper, elastomeric lag damper which is made from silicone rubber is built. And a series of experiments are conducted on this elastomeric lag damper. The stress-strain curves of elastomeric lag dampers employed shear forces at different frequency are obtained. And a finite element model is established based on Burgers model. The result of simulation and tests shows that the simple, linear model will yield good predictions of damper energy dissipation and it is adequate for predicting the stress-strain hysteresis loop within the operating frequency and a small-amplitude oscillation.

GHRH excess and blockade in X-LAG syndrome.

PubMed

Daly, Adrian F; Lysy, Philippe A; Desfilles, Céline; Rostomyan, Liliya; Mohamed, Amira; Caberg, Jean-Hubert; Raverot, Veronique; Castermans, Emilie; Marbaix, Etienne; Maiter, Dominique; Brunelle, Chloe; Trivellin, Giampaolo; Stratakis, Constantine A; Bours, Vincent; Raftopoulos, Christian; Beauloye, Veronique; Barlier, Anne; Beckers, Albert

2016-03-01

X-linked acrogigantism (X-LAG) syndrome is a newly described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated GH and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GHRH levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(d-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. © 2016 Society for Endocrinology.

Met UM Upper-tropospheric summer jet teleconnections: A model assessment

NASA Astrophysics Data System (ADS)

Joao Carvalho, Maria; Rodriguez, Jose; Milton, Sean

2017-04-01

The upper tropospheric jet stream has been documented to act as a waveguide (Hoskins and Ambrizzi, 1993) and supporting quasi-stationary Rossby waves (Schubert et al. 2011). These have been associated with remote effects in surface level weather such as rainfall anomalies in the East Asian Summer Monsoon as well as extreme temperature events. The goal of this work was to analyse the intraseasonal to interannual upper level boreal summer jet variability and its coupling with low level atmospheric dynamics within the Met Office Unified Model using climate runs. Using the Wallace and Gutzler (1981) proposed approach to find teleconnection patterns on the 200 hPa level wind, lead-lag correlation and Empirical Orthogonal Function analysis on the upper-level jet and relating the results with surface weather variables as well as dynamical variables, it was found that the model presents too strong jet variability, particularly in the tropical region and. In addition, the model presents high teleconnectivity hotspots with higher importance in areas such as the Mediterranean and Caspian Sea which are important source areas for Rossby Waves. Further to this, the model was found to produce an area of teleconnectivity between the tropical Atlantic and western Africa which is not observed in the reanalysis but coexists with long lasting precipitation biases. As comparison for the model results, ERA-Interim circulation and wind data and the TRMM precipitation dataset were used. In order to assess the relative importance of relevant model parameters in the biases and process errors, work is currently underway using perturbed model parameter ensembles.

A Unified Theory for the Great Plains Nocturnal Low-Level Jet

NASA Astrophysics Data System (ADS)

Shapiro, A.; Fedorovich, E.; Rahimi, S.

2014-12-01

The nocturnal low-level jet (LLJ) is a warm-season atmospheric boundary layer phenomenon common to the Great Plains of the United States and other places worldwide, typically in regions east of mountain ranges. Low-level jets develop around sunset in fair weather conditions conducive to strong radiational cooling, reach peak intensity in the pre-dawn hours, and then dissipate with the onset of daytime convective mixing. In this study we consider the LLJ as a diurnal oscillation of a stably stratified atmosphere overlying a planar slope on the rotating Earth. The oscillations arise from diurnal cycles in both the heating of the slope (mechanism proposed by Holton in 1967) and the turbulent mixing (mechanism proposed by Blackadar in 1957). The governing equations are the equations of motion, incompressibility condition, and thermal energy in the Boussinesq approximation, with turbulent heat and momentum exchange parameterized through spatially constant but diurnally varying turbulent diffusion coefficients (diffusivities). Analytical solutions are obtained for diffusivities with piecewise constant waveforms (step-changes at sunrise and sunset) and slope temperatures/buoyancies with piecewise linear waveforms (saw-tooth function with minimum at sunrise and maximum before sunset). The jet characteristics are governed by eleven parameters: slope angle, Coriolis parameter, environmental buoyancy frequency, geostrophic wind strength, daytime and nighttime diffusivities, maximum (daytime) and minimum (nighttime) slope buoyancies, duration of daylight, lag time between peak slope buoyancy and sunset, and a Newtonian cooling time scale. An exploration of the parameter space yields results that are broadly consistent with findings particular to the Holton and Blackadar theories, and agree with climatological observations, for example, that stronger jets tend to occur over slopes of 0.15-0.25 degrees characteristic of the Great Plains. The solutions also yield intriguing

Lags in the response of mountain plant communities to climate change.

PubMed

Alexander, Jake M; Chalmandrier, Loïc; Lenoir, Jonathan; Burgess, Treena I; Essl, Franz; Haider, Sylvia; Kueffer, Christoph; McDougall, Keith; Milbau, Ann; Nuñez, Martin A; Pauchard, Aníbal; Rabitsch, Wolfgang; Rew, Lisa J; Sanders, Nathan J; Pellissier, Loïc

2018-02-01

Rapid climatic changes and increasing human influence at high elevations around the world will have profound impacts on mountain biodiversity. However, forecasts from statistical models (e.g. species distribution models) rarely consider that plant community changes could substantially lag behind climatic changes, hindering our ability to make temporally realistic projections for the coming century. Indeed, the magnitudes of lags, and the relative importance of the different factors giving rise to them, remain poorly understood. We review evidence for three types of lag: "dispersal lags" affecting plant species' spread along elevational gradients, "establishment lags" following their arrival in recipient communities, and "extinction lags" of resident species. Variation in lags is explained by variation among species in physiological and demographic responses, by effects of altered biotic interactions, and by aspects of the physical environment. Of these, altered biotic interactions could contribute substantially to establishment and extinction lags, yet impacts of biotic interactions on range dynamics are poorly understood. We develop a mechanistic community model to illustrate how species turnover in future communities might lag behind simple expectations based on species' range shifts with unlimited dispersal. The model shows a combined contribution of altered biotic interactions and dispersal lags to plant community turnover along an elevational gradient following climate warming. Our review and simulation support the view that accounting for disequilibrium range dynamics will be essential for realistic forecasts of patterns of biodiversity under climate change, with implications for the conservation of mountain species and the ecosystem functions they provide. © 2017 John Wiley & Sons Ltd.

Spectral evolution of GRBs with negative spectral lag using Fermi GBM observations

NASA Astrophysics Data System (ADS)

Chakrabarti, Arundhati; Chaudhury, Kishor; Sarkar, Samir K.; Bhadra, Arunava

2018-06-01

The positive spectral lag of Gamma Ray Bursts (GRBs) is often explained in terms of hard-to-soft spectral evolution of GRB pulses. While positive lags of GRBs is very common, there are few GRB pulses that exhibits negative spectral lags. In the present work we examine whether negative lags of GRBs also can be interpreted in terms of spectral evolution of GRB pulses or not. Using Fermi-GBM data, we identify two GRBs, GRB 090426C and GRB 150213A, with clean pulses that exhibit negative spectral lag. An indication of soft to hard transition has been noticed for the negative spectral lag events from the spectral evolution study. The implication of the present findings on the models of GRB spectral lags are discussed.

Examining the intertwined development of prosocial skills and ASD symptoms in adolescence.

PubMed

Oerlemans, Anoek M; Rommelse, Nanda N J; Buitelaar, Jan K; Hartman, Catharina A

2018-01-30

Autism spectrum disorder (ASD) and reduced prosocial behaviour are strongly intertwined. However, social interactions with peers may be increasingly practiced over the course of development and may instigate a reduction in ASD symptoms and vice versa. We, therefore, sought to determine if, during adolescence, possible improvements in prosocial behaviours and ASD symptoms may benefit one another over time. Participants were 2773 adolescents from the Tracking Adolescents' Individual Lives Survey (TRAILS) cohorts. Measurements took place over three waves (mean ages: 11.1, 13.4, and 16.2 years). Longitudinal associations between teacher-rated classroom prosocial skills and parent-rated ASD symptoms were examined using the random intercept cross-lagged panel model (RI-CLPM). In addition to estimating the stable, between-person associations, the dynamical effects between prosocial skills and ASD symptoms over time were estimated at the within-person level. At the between-person level, prosocial skills and ASD symptoms were substantially negatively correlated. At the within-person level, a small and unexpected positive cross-lagged effect from wave 1 ASD symptoms on wave 2 prosocial skills was observed. We added to the existing literature by showing that, in addition to replicating the already firmly established between-person association between low prosocial skills and ASD, within-person gains in prosocial skills do not lead to subsequent reduction of ASD symptoms, and reductions in ASD symptoms do not lead to subsequent enhancement of prosocial skills. We, therefore, conclude from our findings that the inverse association between autistic symptoms and prosocial skills in adolescence is highly stable.

A Connection Between Corona and Jet

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-03-01

The structure immediately around a supermassive black hole at the heart of an active galaxy can tell us about how material flows in and out of these monsters but this region is hard to observe! A new study provides us with clues of what might be going on in these active and energetic cores of galaxies.In- and OutflowsIn active galactic nuclei (AGN), matter flows both in and out. As material flows toward the black hole via its surrounding accretion disk, much of this gas and dust can then be expelled from the vicinity via highly collimated jets.Top: The fraction of X-rays that is reflected decreases as jet power increases. Bottom: the distance between the corona and the reflecting part of the disk increases as jet power increases. [Adapted from King et al. 2017]To better understand this symbiosis between accretion and outflows, we examine whats known as the corona the hot, X-ray-emitting gas thats located in the closest regions around the black hole. But because the active centers of galaxies are generally obscured by surrounding gas and dust, its difficult for us to learn about the structure of these inner regions near the black hole.Where are the X-rays of the corona produced: in the inner accretion flow, or at the base of the jet? How far away is this corona from the disk? And how does the coronas behavior relate to that of the jet?Reflected ObservationsTo address some of these questions, a group of scientists led by Ashley King (Einstein Fellow at Stanford University) has analyzed X-ray observations from NuSTAR and XMM-Newton of over 40 AGN. The team examined the reflections of the X-rays off of the accretion disk and used two measurements to learn about the structure around the black hole:the fraction of the coronas X-rays that are reflected by the disk, andthe time lag between the original and reflected X-rays, which reveals the distance from the corona to the reflecting part of the disk.A visualization of the authors model for an AGN. The accretion disk is

Factors Influencing Time Lag between First Parental Concern and First Visit to Child Psychiatric Services in Children with Autism Spectrum Disorders in Japan

ERIC Educational Resources Information Center

Fujiwara, Takeo; Okuyama, Makiko; Funahashi, Keiichi

2011-01-01

The early assessment of autism spectrum disorders (ASDs) is important to improving patient outcomes, allowing family members to prepare for and cope with symptoms, and assisting in plans for appropriate educational opportunities. However, little is known about factors that influence the time lag between the parents' first concerns and the first…

Jet angularity measurements for single inclusive jet production

NASA Astrophysics Data System (ADS)

Kang, Zhong-Bo; Lee, Kyle; Ringer, Felix

2018-04-01

We study jet angularity measurements for single-inclusive jet production at the LHC. Jet angularities depend on a continuous parameter a allowing for a smooth interpolation between different traditional jet shape observables. We establish a factorization theorem within Soft Collinear Effective Theory (SCET) where we consistently take into account in- and out-of-jet radiation by making use of semi-inclusive jet functions. For comparison, we elaborate on the differences to jet angularities measured on an exclusive jet sample. All the necessary ingredients for the resummation at next-to-leading logarithmic (NLL) accuracy are presented within the effective field theory framework. We expect semiinclusive jet angularity measurements to be feasible at the LHC and we present theoretical predictions for the relevant kinematic range. In addition, we investigate the potential impact of jet angularities for quark-gluon discrimination.

Emergence and temporal structure of Lead-Lag correlations in collective stock dynamics

NASA Astrophysics Data System (ADS)

Xia, Lisi; You, Daming; Jiang, Xin; Chen, Wei

2018-07-01

Understanding the correlations among stock returns is crucial for reducing the risk of investment in stock markets. As an important stylized correlation, lead-lag effect plays a major role in analyzing market volatility and deriving trading strategies. Here, we explore historical lead-lag relationships among stocks in the Chinese stock market. Strongly positive lagged correlations can be empirically observed. We demonstrate this lead-lag phenomenon is not constant but temporally emerges during certain periods. By introducing moving time window method, we transform the lead-lag dynamics into a series of asymmetric lagged correlation matrices. Dynamic lead-lag structures are uncovered in the form of temporal network structures. We find that the size of lead-lag group experienced a rapid drop during the year 2012, which signaled a re-balance of the stock market. On the daily timescale, we find the lead-lag structure exhibits several persistent patterns, which can be characterized by the Jaccard matrix. We show significant market events can be distinguished in the Jaccard matrix diagram. Taken together, we study an integration of all the temporal networks and identify several leading stock sectors, which are in accordance with the common Chinese economic fundamentals.

Unsteady loads due to propulsive lift configurations. Part C: Development of experimental techniques for investigation of unsteady pressures behind a cold model jet

NASA Technical Reports Server (NTRS)

Haviland, J. K.; Schroeder, J. C.

1978-01-01

As part of an overall study of the scaling laws for the fluctuating pressures induced on the wings and flaps of STOL aircraft by jet engine impingement, an experimental investigation was made of the near field fluctuating pressures behind a cold circular jet, both when it was free and when it was impinging on a flat plate. Miniature static pressure probes were developed for measurements in the free jet and on the flat plate which were connected by plastic tubing to 1/8 inch microphones and acted as pressure transducers. Using a digital correlator together with an FFT program on the CDC 6400 computer, spectral densities, relative amplitudes, phase lags, and coherences were also obtained for the signals from pairs of these probes, and were used to calibrate these probes directly against microphones. This system of instrumentation was employed to obtain single point rms and third octave surveys of the static pressures in the free jet and on the surface of the plate.

Mechanisms of Zero-Lag Synchronization in Cortical Motifs

PubMed Central

Gollo, Leonardo L.; Mirasso, Claudio; Sporns, Olaf; Breakspear, Michael

2014-01-01

Zero-lag synchronization between distant cortical areas has been observed in a diversity of experimental data sets and between many different regions of the brain. Several computational mechanisms have been proposed to account for such isochronous synchronization in the presence of long conduction delays: Of these, the phenomenon of “dynamical relaying” – a mechanism that relies on a specific network motif – has proven to be the most robust with respect to parameter mismatch and system noise. Surprisingly, despite a contrary belief in the community, the common driving motif is an unreliable means of establishing zero-lag synchrony. Although dynamical relaying has been validated in empirical and computational studies, the deeper dynamical mechanisms and comparison to dynamics on other motifs is lacking. By systematically comparing synchronization on a variety of small motifs, we establish that the presence of a single reciprocally connected pair – a “resonance pair” – plays a crucial role in disambiguating those motifs that foster zero-lag synchrony in the presence of conduction delays (such as dynamical relaying) from those that do not (such as the common driving triad). Remarkably, minor structural changes to the common driving motif that incorporate a reciprocal pair recover robust zero-lag synchrony. The findings are observed in computational models of spiking neurons, populations of spiking neurons and neural mass models, and arise whether the oscillatory systems are periodic, chaotic, noise-free or driven by stochastic inputs. The influence of the resonance pair is also robust to parameter mismatch and asymmetrical time delays amongst the elements of the motif. We call this manner of facilitating zero-lag synchrony resonance-induced synchronization, outline the conditions for its occurrence, and propose that it may be a general mechanism to promote zero-lag synchrony in the brain. PMID:24763382

Monthly ENSO Forecast Skill and Lagged Ensemble Size

PubMed Central

DelSole, T.; Tippett, M.K.; Pegion, K.

2018-01-01

Abstract The mean square error (MSE) of a lagged ensemble of monthly forecasts of the Niño 3.4 index from the Climate Forecast System (CFSv2) is examined with respect to ensemble size and configuration. Although the real‐time forecast is initialized 4 times per day, it is possible to infer the MSE for arbitrary initialization frequency and for burst ensembles by fitting error covariances to a parametric model and then extrapolating to arbitrary ensemble size and initialization frequency. Applying this method to real‐time forecasts, we find that the MSE consistently reaches a minimum for a lagged ensemble size between one and eight days, when four initializations per day are included. This ensemble size is consistent with the 8–10 day lagged ensemble configuration used operationally. Interestingly, the skill of both ensemble configurations is close to the estimated skill of the infinite ensemble. The skill of the weighted, lagged, and burst ensembles are found to be comparable. Certain unphysical features of the estimated error growth were tracked down to problems with the climatology and data discontinuities. PMID:29937973

Monthly ENSO Forecast Skill and Lagged Ensemble Size

NASA Astrophysics Data System (ADS)

Trenary, L.; DelSole, T.; Tippett, M. K.; Pegion, K.

2018-04-01

The mean square error (MSE) of a lagged ensemble of monthly forecasts of the Niño 3.4 index from the Climate Forecast System (CFSv2) is examined with respect to ensemble size and configuration. Although the real-time forecast is initialized 4 times per day, it is possible to infer the MSE for arbitrary initialization frequency and for burst ensembles by fitting error covariances to a parametric model and then extrapolating to arbitrary ensemble size and initialization frequency. Applying this method to real-time forecasts, we find that the MSE consistently reaches a minimum for a lagged ensemble size between one and eight days, when four initializations per day are included. This ensemble size is consistent with the 8-10 day lagged ensemble configuration used operationally. Interestingly, the skill of both ensemble configurations is close to the estimated skill of the infinite ensemble. The skill of the weighted, lagged, and burst ensembles are found to be comparable. Certain unphysical features of the estimated error growth were tracked down to problems with the climatology and data discontinuities.

Lag and anticipating synchronization without time-delay coupling.

PubMed

Corron, Ned J; Blakely, Jonathan N; Pethel, Shawn D

2005-06-01

We describe a new method for achieving approximate lag and anticipating synchronization in unidirectionally coupled chaotic oscillators. The method uses a specific parameter mismatch between the drive and response that is a first-order approximation to true time-delay coupling. As a result, an adjustable lag or anticipation effect can be achieved without the need for a variable delay line, making the method simpler and more economical to implement in many physical systems. We present a stability analysis, demonstrate the method numerically, and report experimental observation of the effect in radio-frequency electronic oscillators. In the circuit experiments, both lag and anticipation are controlled by tuning a single capacitor in the response oscillator.

Signatures of Steady Heating in Time Lag Analysis of Coronal Emission

NASA Technical Reports Server (NTRS)

Viall, Nicholeen M.; Klimchuk, James A.

2016-01-01

Among the multitude of methods used to investigate coronal heating, the time lag method of Viall Klimchuk is becoming increasingly prevalent as an analysis technique that is complementary to those that are traditionally used.The time lag method cross correlates light curves at a given spatial location obtained in spectral bands that sample different temperature plasmas. It has been used most extensively with data from the Atmospheric Imaging Assembly on the Solar Dynamics Observatory. We have previously applied the time lag method to entire active regions and surrounding the quiet Sun and created maps of the results. We find that the majority of time lags are consistent with the cooling of coronal plasma that has been impulsively heated. Additionally, a significant fraction of the map area has a time lag of zero. This does not indicate a lack of variability. Rather, strong variability must be present, and it must occur in phase between the different channels. We have previously shown that these zero time lags are consistent with the transition region response to coronal nanoflares, although other explanations are possible. A common misconception is that the zero time lag indicates steady emission resulting from steady heating. Using simulated and observed light curves, we demonstrate here that highly correlated light curves at zero time lag are not compatible with equilibrium solutions. Such light curves can only be created by evolution

Symptoms and subjective quality of life in post-traumatic stress disorder: a longitudinal study.

PubMed

Giacco, Domenico; Matanov, Aleksandra; Priebe, Stefan

2013-01-01

Evidence suggests that post-traumatic stress disorder (PTSD) is associated with substantially reduced subjective quality of life (SQOL). This study aimed to explore whether and how changes in the levels of PTSD symptom clusters of intrusion, avoidance and hyperarousal are associated with changes in SQOL. Two samples with PTSD following the war in former Yugoslavia were studied, i.e. a representative sample of 530 people in five Balkan countries and a non-representative sample of 215 refugees in three Western European countries. They were assessed on average eight years after the war and re-interviewed one year later. PTSD symptoms were assessed on the Impact of Event Scale - Revised and SQOL on the Manchester Short Assessment of Quality of Life. Linear regression and a two-wave cross lagged panel analysis were used to explore the association between PTSD symptom clusters and SQOL. The findings in the two samples were consistent. Symptom reduction over time was associated with improved SQOL. In multivariable analyses adjusted for the influence of all three clusters, gender and time since war exposure, only changes in hyperarousal symptoms were significantly associated with changes in SQOL. The two-wave cross-lagged panel analysis suggested that the link between hyperarousal symptoms and SQOL is bidirectional. Low SQOL of patients with war-related PTSD is particularly associated with hyperarousal symptoms. The findings suggest a bidirectional influence: a reduction in hyperarousal symptoms may result in improved SQOL, and improvements in SQOL may lead to reduced hyperarousal symptoms.

Deflection of jets induced by jet-cloud and jet-galaxy interactions

NASA Astrophysics Data System (ADS)

Mendoza, S.; Longair, M. S.

2001-06-01

The model first introduced by Raga & Cantó in which astrophysical jets are deflected on passing through an isothermal high-density region is generalized by taking into account gravitational effects on the motion of the jet as it crosses the high-density cloud. The problem is also generalized for relativistic jets in which gravitational effects induced by the cloud are neglected. Two further cases, classical and relativistic, are discussed for the cases in which the jet is deflected on passing through the interstellar gas of a galaxy in which a dark matter halo dominates the gravitational potential. The criteria for the stability of jets due to the formation of internal shocks are also discussed.

LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses.

PubMed

Cook, Kevin D; Whitmire, Jason K

2016-07-01

Ongoing clinical trials are evaluating the benefits of systemic blockade of lymphocyte activation gene-3 (LAG-3) signals to improve immunity to tumors. Those studies are founded on the well-established inhibitory role of LAG-3 in regulating CD8(+) T cells during chronic virus infection and antitumor responses. However, the T cell response in LAG-3-deficient mice is similar in size and function to that in wild type animals, suggesting LAG-3 has nuanced immune-regulatory functions. We performed a series of adoptive transfer experiments in mice to better understand the T cell-intrinsic functions of LAG-3 in the regulation of CD8(+) T cell responses. Our results indicate that LAG-3 expression by CD8(+) T cells inhibits their competitive fitness and results in a slightly reduced rate of cell division in comparison with LAG-3-deficient cells. This cell-intrinsic effect of LAG-3 was consistent across both acute and chronic virus infections. These data show that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8(+) T cell responses. Copyright © 2016 by The American Association of Immunologists, Inc.

Animal Models of Jet Lag

DTIC Science & Technology

2012-01-20

surgically inserted into the pineal gland and connected to a peristaltic pump that delivers saline solution at low rate and to a outlet tubing that delivers...Journal of Pineal Research. 48(3):290- 6,2010. 2. "Orcadian Regulation of Pineal Gland Rhythmicity", Jimo Borjigin, L. Samantha Zhang, Anda-Alexandra...specializes in the longitudinal monitoring of pineal melatonin secretion for weeks at a time to decipher mechanisms of circadian pacemaker entrainment

The drug lag: an interpretive review of the literature.

PubMed

Schifrin, L G; Tayan, J R

1977-01-01

This articel reviews the literature pertinent to the "drug lag" issue, in order to evaluate the evidence underlying the thesis that the U.S. has suffered from a slow-down in the rate and timing of new drug introductions, to the detriment of patients, because of the stricter requirements since 1962 regarding proof of safety and efficacy for new drugs. Comparing the post-1962 record in the U.S. with (a) the U.S. record before 1962 and (b) the post-1962 record in other, mainly Western European, countries, the weight of evidence and argument falls on the side of those who see a lag existing in the U.S. Other evidence, more subjective, supports the view that this lag imposes net positive costs on U.S. patients. However, it is not clear that the 1962 Drug Act is the sole, or even the main, cause of the lag. Instead, the drug information system and its inefficiencies emerge as the fundamental reason for the existence of a lag; hence, changes in the administration of the law by the Food and Drug Administration and greater efficiency by companies in supporting New Drug Applications can help close the gap, but probably only in minor degree. The solution to the lag problem lies in formulating and implementing a drug information system that quickly and accurately gathers, interprets, and disseminates information on the positive and negative effects of newly introduced drugs; with such a system, protection of drug users from undue risk is compatible with a greater rate and more rapid appearance of new drug discoveries.

Improving the effectiveness of an interruption lag by inducing a memory-based strategy.

PubMed

Morgan, Phillip L; Patrick, John; Tiley, Leyanne

2013-01-01

The memory for goals model (Altmann & Trafton, 2002) posits the importance of a short delay (the 'interruption lag') before an interrupting task to encode suspended goals for retrieval post-interruption. Two experiments used the theory of soft constraints (Gray, Simms, Fu & Schoelles, 2006) to investigate whether the efficacy of an interruption lag could be improved by increasing goal-state access cost to induce a more memory-based encoding strategy. Both experiments used a copying task with three access cost conditions (Low, Medium, and High) and a 5-s interruption lag with a no lag control condition. Experiment 1 found that the participants in the High access cost condition resumed more interrupted trials and executed more actions correctly from memory when coupled with an interruption lag. Experiment 2 used a prospective memory test post-interruption and an eyetracker recorded gaze activity during the interruption lag. The participants in the High access cost condition with an interruption lag were best at encoding target information during the interruption lag, evidenced by higher scores on the prospective memory measure and more gaze activity on the goal-state during the interruption lag. Theoretical and practical issues regarding the use of goal-state access cost and an interruption lag are discussed. Copyright © 2012. Published by Elsevier B.V.

Modelling of capital asset pricing by considering the lagged effects

NASA Astrophysics Data System (ADS)

Sukono; Hidayat, Y.; Bon, A. Talib bin; Supian, S.

2017-01-01

In this paper the problem of modelling the Capital Asset Pricing Model (CAPM) with the effect of the lagged is discussed. It is assumed that asset returns are analysed influenced by the market return and the return of risk-free assets. To analyse the relationship between asset returns, the market return, and the return of risk-free assets, it is conducted by using a regression equation of CAPM, and regression equation of lagged distributed CAPM. Associated with the regression equation lagged CAPM distributed, this paper also developed a regression equation of Koyck transformation CAPM. Results of development show that the regression equation of Koyck transformation CAPM has advantages, namely simple as it only requires three parameters, compared with regression equation of lagged distributed CAPM.

Jet Fuel-Associated Occupational Contact Dermatitis.

PubMed

Contestable, James J

2017-03-01

Occupational contact dermatitis is a ubiquitous problem. Sailors onboard U.S. Navy vessels are at high risk given the multitude of potential workplace exposures. Solvents, petrochemicals, and fuels are abundant and can cause irritant or allergic contact dermatitis. Symptoms of contact dermatitis can cause inability to work and, if chronic, may require a change in rating or job. Prevention of this issue requires patient education about the risks and correct personnel protective equipment. Even with preventative strategies in place, exposures and cases of contact dermatitis will occur. Treatment consists of topical steroids and immunomodulators, as well as barrier creams and emollients. The goal of treatment is to fully restore the skin's natural barrier and prevent further exposure. A classic case of jet fuel-associated contact dermatitis is reviewed. A literature review utilizing PubMed, Google Scholar, and Google Search was conducted to elucidate our understanding of this issue, current occupational health guidelines, preventative approaches, and treatments. This case report provides guidance and recommendations for providers who encounter contact dermatitis related to petrochemicals, such as jet fuel. The literature review revealed limited knowledge surrounding in vivo human skin effects of jet fuel, specifically JP-5. Even larger gaps were found in our understanding of, and guidelines for, protective modalities against jet fuel exposure and dermatitis. A case is presented to facilitate recognition of jet fuel contact dermatitis and guidance for treatment and prevention. Given our current limited knowledge and guidelines concerning protective equipment and skin protectants, multiple proposals for future studies are suggested. Reprint & Copyright © 2017 Association of Military Surgeons of the U.S.

Hydrodynamic Stability Analysis of Multi-jet Effects in Swirling Jet Combustors

NASA Astrophysics Data System (ADS)

Emerson, Benjamin; Lieuwen, Tim

2016-11-01

Many practical combustion devices use multiple swirling jets to stabilize flames. However, much of the understanding of swirling jet dynamics has been generated from experimental and computational studies of single reacting, swirling jets. A smaller body of literature has begun to explore the effects of multi-jet systems and the role of jet-jet interactions on the macro-system dynamics. This work uses local temporal and spatio-temporal stability analyses to isolate the hydrodynamic interactions of multiple reacting, swirling jets, characterized by jet diameter, D, and spacing, L. The results first identify the familiar helical modes in the single jet. Comparison to the multi-jet configuration reveals these same familiar modes simultaneously oscillating in each of the jets. Jet-jet interaction is mostly limited to a spatial synchronization of each jet's oscillations at the jet spacing values analyzed here (L/D =3.5). The presence of multiple jets vs a single jet has little influence on the temporal and absolute growth rates. The biggest difference between the single and multi-jet configurations is the presence of nearly degenerate pairs of hydrodynamic modes in the multi-jet case, with one mode dominated by oscillations in the inner jet, and the other in the outer jets. The close similarity between the single and multi-jet hydrodynamics lends insight into experiments from our group.

Time-lag effects of global vegetation responses to climate change.

PubMed

Wu, Donghai; Zhao, Xiang; Liang, Shunlin; Zhou, Tao; Huang, Kaicheng; Tang, Bijian; Zhao, Wenqian

2015-09-01

Climate conditions significantly affect vegetation growth in terrestrial ecosystems. Due to the spatial heterogeneity of ecosystems, the vegetation responses to climate vary considerably with the diverse spatial patterns and the time-lag effects, which are the most important mechanism of climate-vegetation interactive effects. Extensive studies focused on large-scale vegetation-climate interactions use the simultaneous meteorological and vegetation indicators to develop models; however, the time-lag effects are less considered, which tends to increase uncertainty. In this study, we aim to quantitatively determine the time-lag effects of global vegetation responses to different climatic factors using the GIMMS3g NDVI time series and the CRU temperature, precipitation, and solar radiation datasets. First, this study analyzed the time-lag effects of global vegetation responses to different climatic factors. Then, a multiple linear regression model and partial correlation model were established to statistically analyze the roles of different climatic factors on vegetation responses, from which the primary climate-driving factors for different vegetation types were determined. The results showed that (i) both the time-lag effects of the vegetation responses and the major climate-driving factors that significantly affect vegetation growth varied significantly at the global scale, which was related to the diverse vegetation and climate characteristics; (ii) regarding the time-lag effects, the climatic factors explained 64% variation of the global vegetation growth, which was 11% relatively higher than the model ignoring the time-lag effects; (iii) for the area with a significant change trend (for the period 1982-2008) in the global GIMMS3g NDVI (P < 0.05), the primary driving factor was temperature; and (iv) at the regional scale, the variation in vegetation growth was also related to human activities and natural disturbances. Considering the time-lag effects is quite

Effects of long-haul transmeridian travel on player preparedness: Case study of a national team at the 2014 FIFA World Cup.

PubMed

Fowler, Peter M; McCall, Alan; Jones, Mark; Duffield, Rob

2017-04-01

Describe the effects of eastward long-haul transmeridian air travel on subjective jet-lag, sleep and wellness in professional football (soccer) players prior to the 2014 FIFA World Cup in Brazil. Single cohort involving twenty-two male professional football players representing a national football team. Data was collected from players prior to and following international travel from Sydney, Australia to Vitoria, Brazil. In total there were three flights, 19-h and 14,695km of travel east across 11 time-zones. Training load and wellness measures were obtained in the week prior to and following travel, whilst sleep and jet-lag measures were collected on the day prior to travel (Pre), the day of arrival and for five days following travel (Post 1-5). Compared to Pre, perceived jet-lag was significantly increased on Post 1 to 4, with significantly greater levels on Post 1 compared to Post 5 (p<0.05). Self-reported sleep duration during travel was 5.9 (4.8-7.0) h, which was significantly lower than all other nights (p˂0.01), except for the night of arrival, where time in bed and sleep duration were significantly reduced compared to Post 1-4 (p˂0.01). Lastly, compared to the week prior to travel, mean wellness was significantly reduced during the week following travel (p˂0.01). Self-reported sleep disruption during and following eastward long-haul transmeridian air travel, together with exacerbated jet-lag symptoms may result in reduced player wellness. Consequently, player preparedness for subsequent training and competition may be impeded, though physical performance data is lacking. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Fuzzy jets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mackey, Lester; Nachman, Benjamin; Schwartzman, Ariel

Collimated streams of particles produced in high energy physics experiments are organized using clustering algorithms to form jets . To construct jets, the experimental collaborations based at the Large Hadron Collider (LHC) primarily use agglomerative hierarchical clustering schemes known as sequential recombination. We propose a new class of algorithms for clustering jets that use infrared and collinear safe mixture models. These new algorithms, known as fuzzy jets , are clustered using maximum likelihood techniques and can dynamically determine various properties of jets like their size. We show that the fuzzy jet size adds additional information to conventional jet tagging variablesmore » in boosted topologies. Furthermore, we study the impact of pileup and show that with some slight modifications to the algorithm, fuzzy jets can be stable up to high pileup interaction multiplicities.« less

Fuzzy jets

DOE PAGES

Mackey, Lester; Nachman, Benjamin; Schwartzman, Ariel; ...

2016-06-01

Collimated streams of particles produced in high energy physics experiments are organized using clustering algorithms to form jets . To construct jets, the experimental collaborations based at the Large Hadron Collider (LHC) primarily use agglomerative hierarchical clustering schemes known as sequential recombination. We propose a new class of algorithms for clustering jets that use infrared and collinear safe mixture models. These new algorithms, known as fuzzy jets , are clustered using maximum likelihood techniques and can dynamically determine various properties of jets like their size. We show that the fuzzy jet size adds additional information to conventional jet tagging variablesmore » in boosted topologies. Furthermore, we study the impact of pileup and show that with some slight modifications to the algorithm, fuzzy jets can be stable up to high pileup interaction multiplicities.« less

TEMPORARY WORK AND DEPRESSIVE SYMPTOMS: A PROPENSITY SCORE ANALYSIS

PubMed Central

Quesnel-Vallée, Amélie; DeHaney, Suzanne; Ciampi, Antonio

2013-01-01

Recent decades have seen a tremendous increase in the complexity of work arrangements, through job sharing, flexible hours, career breaks, compressed work weeks, shift work, reduced job security, and part-time, contract and temporary work. In this study, we focus on one specific group of workers that arguably most embodies nonstandard employment, namely temporary workers, and examine the consequences of this type of employment on depressive symptoms. This study aims to estimate the effect of being a temporary worker on depressive symptom severity. Accounting for the possibility of mental health selection into temporary work through propensity score analysis, we isolate the direct effects of temporary work on depressive symptoms with varying lags of time since exposure. We use prospective data from the U.S. National Longitudinal Survey of Youth 1979 (NLSY79), which has followed, longitudinally, from 1979 to the present, a nationally representative cohort of American men and women between 14 and 22 years of age in 1979. Three propensity score models were estimated, to capture the effect of different time lags (immediately following exposure, and 2 and 4 years post exposure) between the period of exposure to the outcome. The only significant effects were found among those who had been exposed to temporary work in the two years preceding the outcome measurement. These workers report 1.803 (95% CI 0.552; 3.055) additional depressive symptoms from having experienced this work status (than if they had not been exposed). Moreover, this difference is both statistically and substantively significant, as it represents a 50% increase from the average level of depressive symptoms in this population. PMID:20371142

New Probe of Early Phases of Jet Formation and Evolution using Stellar Tidal Disruption Flares

NASA Astrophysics Data System (ADS)

Ranga Reddy Pasham, Dheeraj; van Velzen, Sjoert

2018-01-01

The tidal disruption of a star by a supermassive black hole can result in transient radio emission. The electrons producing these synchrotron radio flares could either be accelerated inside a relativistic jet or externally by shocks resulting from an outflow interacting with the circumnuclear medium. Until now, evidence for the internal emission mechanism has been lacking; nearly all tidal disruption flare studies have adopted the external shock model to explain the observed properties of radio flares. I will talk about a result that presents a challenge to external emission models: we discovered a cross-correlation between the soft X-ray (0.3-1 keV) and 16 GHz radio flux of Rosetta Stone tidal disruption flare ASASSN-14li. Variability features in the X-ray light curve appear again in the radio light curve, but after a time lag of about 13 days. This demonstrates that soft X-ray emitting accretion disk regulates the radio emission. This coupling appears to be inconsistent with all previous external emission models for this source but is naturally explained if the radio emission originates from a freely expanding jet. I will show that emission internal to an adiabatically expanding jet can also reproduce the observed evolution of the radio spectral energy distribution. Furthermore, both the correlation between X-ray and radio luminosity as well as our radio spectral modeling imply an approximately linear coupling between the accretion rate and jet power. I will also discuss how future tidal disruption events can help us understand how jets form and evolve in general.

LAG-3 confers a competitive disadvantage upon antiviral CD8+ T cell responses1

PubMed Central

Cook, Kevin D.; Whitmire, Jason K.

2016-01-01

Ongoing clinical trials are evaluating the benefits of systemic blockade of lymphocyte activation gene-3 (LAG-3) signals to improve immunity to tumors. Those studies are founded on the well-established inhibitory role of LAG-3 in regulating CD8+ T cells during chronic virus infection and anti-tumor responses. However, the T cell response in LAG-3 deficient mice is similar in size and function to that in wild type animals, suggesting LAG-3 has nuanced immune-regulatory functions. We performed a series of adoptive transfer experiments in mice to better understand the T cell-intrinsic functions of LAG-3 in the regulation of CD8+ T cell responses. Our results indicate that LAG-3 expression by CD8+ T cells inhibits their competitive fitness and results in a slightly reduced rate of cell division in comparison to LAG-3 deficient cells. This cell-intrinsic effect of LAG-3 was consistent across both acute and chronic virus infections. These data show that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8+ T cell responses. PMID:27206765

A Race Against Time: Time Lags in Terrestrial-Aquatic Linkages

NASA Astrophysics Data System (ADS)

Basu, N. B.

2017-12-01

Unprecedented decreases in atmospheric nitrogen (N) deposition together with increases in agricultural N-use efficiency have led to decreases in net anthropogenic N inputs in many eastern U.S. and Canadian watersheds as well as in Europe. Despite such decreases, N concentrations in streams and rivers continue to increase, and problems of coastal eutrophication remain acute. Such a mismatch between N inputs and outputs can arise due to legacy N accumulation and subsequent lag times between implementation of conservation measures and improvements in water quality. In the present study, we quantified such lag times by pairing long-term N input trajectories with stream N concentration data in multiple watersheds in North America. Results show significant nonlinearity between N inputs and outputs, with a strong hysteresis effect indicative of decadal-scale lag times. Lag times were found to be negatively correlated with both tile drainage and watershed slope, with tile drainage being a dominant control in fall and watershed slope being significant during the spring snowmelt period. Quantification of such lags will be crucial to policy-makers as they struggle to set appropriate goals for water quality improvement in human-impacted watersheds.

Sleep disorders - overview

MedlinePlus

... Hypersomina; Daytime sleepiness; Sleep rhythm; Sleep disruptive behaviors; Jet lag ... disrupted sleep schedule include: Irregular sleep-wake syndrome Jet lag syndrome Shift work sleep disorder Delayed sleep ...

When Long-Range Zero-Lag Synchronization is Feasible in Cortical Networks

PubMed Central

Viriyopase, Atthaphon; Bojak, Ingo; Zeitler, Magteld; Gielen, Stan

2012-01-01

Many studies have reported long-range synchronization of neuronal activity between brain areas, in particular in the beta and gamma bands with frequencies in the range of 14–30 and 40–80 Hz, respectively. Several studies have reported synchrony with zero phase lag, which is remarkable considering the synaptic and conduction delays inherent in the connections between distant brain areas. This result has led to many speculations about the possible functional role of zero-lag synchrony, such as for neuronal communication, attention, memory, and feature binding. However, recent studies using recordings of single-unit activity and local field potentials report that neuronal synchronization may occur with non-zero phase lags. This raises the questions whether zero-lag synchrony can occur in the brain and, if so, under which conditions. We used analytical methods and computer simulations to investigate which connectivity between neuronal populations allows or prohibits zero-lag synchrony. We did so for a model where two oscillators interact via a relay oscillator. Analytical results and computer simulations were obtained for both type I Mirollo–Strogatz neurons and type II Hodgkin–Huxley neurons. We have investigated the dynamics of the model for various types of synaptic coupling and importantly considered the potential impact of Spike-Timing Dependent Plasticity (STDP) and its learning window. We confirm previous results that zero-lag synchrony can be achieved in this configuration. This is much easier to achieve with Hodgkin–Huxley neurons, which have a biphasic phase response curve, than for type I neurons. STDP facilitates zero-lag synchrony as it adjusts the synaptic strengths such that zero-lag synchrony is feasible for a much larger range of parameters than without STDP. PMID:22866034

Temporary work and depressive symptoms: a propensity score analysis.

PubMed

Quesnel-Vallée, Amélie; DeHaney, Suzanne; Ciampi, Antonio

2010-06-01

Recent decades have seen a tremendous increase in the complexity of work arrangements, through job sharing, flexible hours, career breaks, compressed work weeks, shift work, reduced job security, and part-time, contract and temporary work. In this study, we focus on one specific group of workers that arguably most embodies non-standard employment, namely temporary workers, and estimate the effect of this type of employment on depressive symptom severity. Accounting for the possibility of mental health selection into temporary work through propensity score analysis, we isolate the direct effects of temporary work on depressive symptoms with varying lags of time since exposure. We use prospective data from the U.S. National Longitudinal Survey of Youth 1979 (NLSY79), which has followed, longitudinally, from 1979 to the present, a nationally representative cohort of American men and women between 14 and 22 years of age in 1979. Three propensity score models were estimated, to capture the effect of different time lags (immediately following exposure, and 2 and 4 years post exposure) between the period of exposure to the outcome. The only significant effects were found among those who had been exposed to temporary work in the two years preceding the outcome measurement. These workers report 1.803 additional depressive symptoms from having experienced this work status (than if they had not been exposed). Moreover, this difference is both statistically and substantively significant, as it represents a 50% increase from the average level of depressive symptoms in this population. Copyright 2010 Elsevier Ltd. All rights reserved.

Associations between the dimensions of perceived togetherness, loneliness, and depressive symptoms among older Finnish people.

PubMed

Pynnönen, Katja; Rantanen, Taina; Kokko, Katja; Tiikkainen, Pirjo; Kallinen, Mauri; Törmäkangas, Timo

2017-07-06

We studied the associations between perceived togetherness, depressive symptoms, and loneliness over a six-month period among 222 people aged 75-79 who reported loneliness or depressive mood at baseline. The present cross-lagged models utilized baseline and six-month follow-up data of a randomized controlled trial that examined the effects of a social intervention on loneliness and depression (ISRCTN78426775). Dimensions of perceived togetherness, i.e. attachment, social integration, guidance, alliance, nurturance, and reassurance of worth, were measured with the Social Provisions Scale, depressive symptoms with a short form of the Geriatric Depression Scale, and loneliness with a single item. After controlling for baseline loneliness and depressive symptoms, baseline higher attachment in all participants and baseline higher opportunity for nurturance in the social intervention group predicted lower depressive mood at follow-up. No cross-lagged associations between the dimensions of perceived togetherness at baseline and loneliness at follow-up were observed. In addition, depressive symptoms and loneliness at baseline tended to negatively predict the dimensions of perceived togetherness at follow-up. Depressive symptoms and loneliness appear to be precursor for perceived togetherness, rather than dimensions of perceived togetherness to be antecedents of loneliness and depressiveness among older people.

Lags in the response of mountain plant communities to climate change

PubMed Central

Alexander, Jake M.; Chalmandrier, Loïc; Lenoir, Jonathan; Burgess, Treena I.; Essl, Franz; Haider, Sylvia; Kueffer, Christoph; McDougall, Keith; Milbau, Ann; Nuñez, Martin A.; Pauchard, Aníbal; Rabitsch, Wolfgang; Rew, Lisa J.; Sanders, Nathan J.; Pellissier, Loïc

2018-01-01

Rapid climatic changes and increasing human influence at high elevations around the world will have profound impacts on mountain biodiversity. However, forecasts from statistical models (e.g. species distribution models) rarely consider that plant community changes could substantially lag behind climatic changes, hindering our ability to make temporally realistic projections for the coming century. Indeed, the magnitudes of lags, and the relative importance of the different factors giving rise to them, remain poorly understood. We review evidence for three types of lag: “dispersal lags” affecting plant species’ spread along elevational gradients, “establishment lags” following their arrival in recipient communities, and “extinction lags” of resident species. Variation in lags is explained by variation among species in physiological and demographic responses, by effects of altered biotic interactions, and by aspects of the physical environment. Of these, altered biotic interactions could contribute substantially to establishment and extinction lags, yet impacts of biotic interactions on range dynamics are poorly understood. We develop a mechanistic community model to illustrate how species turnover in future communities might lag behind simple expectations based on species’ range shifts with unlimited dispersal. The model shows a combined contribution of altered biotic interactions and dispersal lags to plant community turnover along an elevational gradient following climate warming. Our review and simulation support the view that accounting for disequilibrium range dynamics will be essential for realistic forecasts of patterns of biodiversity under climate change, with implications for the conservation of mountain species and the ecosystem functions they provide. PMID:29112781

Effective Iterated Greedy Algorithm for Flow-Shop Scheduling Problems with Time lags

NASA Astrophysics Data System (ADS)

ZHAO, Ning; YE, Song; LI, Kaidian; CHEN, Siyu

2017-05-01

Flow shop scheduling problem with time lags is a practical scheduling problem and attracts many studies. Permutation problem(PFSP with time lags) is concentrated but non-permutation problem(non-PFSP with time lags) seems to be neglected. With the aim to minimize the makespan and satisfy time lag constraints, efficient algorithms corresponding to PFSP and non-PFSP problems are proposed, which consist of iterated greedy algorithm for permutation(IGTLP) and iterated greedy algorithm for non-permutation (IGTLNP). The proposed algorithms are verified using well-known simple and complex instances of permutation and non-permutation problems with various time lag ranges. The permutation results indicate that the proposed IGTLP can reach near optimal solution within nearly 11% computational time of traditional GA approach. The non-permutation results indicate that the proposed IG can reach nearly same solution within less than 1% computational time compared with traditional GA approach. The proposed research combines PFSP and non-PFSP together with minimal and maximal time lag consideration, which provides an interesting viewpoint for industrial implementation.

Drug Lag and Key Regulatory Barriers in the Emerging Markets

PubMed Central

Wileman, Harriet; Mishra, Arun

2010-01-01

There have been numerous investigations targeted at identifying whether a drug lag exists in the mature markets of the US, EU and Japan. This work focuses on the emerging markets because of the potential they hold for the future of the pharmaceutical industry as a consequence of rapid economic and political development. The aims of this work are to ascertain whether a drug lag exists in the emerging markets and how it has changed over time from the 1960s to the 2000s. It will also highlight key regulatory barriers which may contribute to drug lag. The date of the marketing authorisation (MA) approval by the US Food and Drug Administration (FDA) was used as a reference point. A comparison against the company database regarding emerging market specific approval enabled the difference in time and thus the drug lag for that particular market to be calculated. This work concludes that the overall relative drug lag in the emerging markets has decreased over time and that there are seven key regulatory barriers which need to be targeted in order to make further improvements; ‘Western Approval’, local clinical development (LCD), Certificate of Pharmaceutical Product (CPP), Good Manufacturing Practice (GMP), pricing approval, document authentication and harmonisation. PMID:21829782

Flap-Lag-Torsion Stability in Forward Flight

NASA Technical Reports Server (NTRS)

Panda, B.; Chopra, I.

1985-01-01

An aeroelastic stability of three-degree flap-lag-torsion blade in forward flight is examined. Quasisteady aerodynamics with a dynamic inflow model is used. The nonlinear time dependent periodic blade response is calculated using an iterative procedure based on Floquet theory. The periodic perturbation equations are solved for stability using Floquet transition matrix theory as well as constant coefficient approximation in the fixed reference frame. Results are presented for both stiff-inplane and soft-inplane blade configurations. The effects of several parameters on blade stability are examined, including structural coupling, pitch-flap and pitch-lag coupling, torsion stiffness, steady inflow distribution, dynamic inflow, blade response solution and constant coefficient approximation.

Fungal mycelia show lag time before re-growth on endogenous carbon.

PubMed

Pollack, Judith K; Li, Zheng Jian; Marten, Mark R

2008-06-15

Nutrient starvation is a common occurrence for filamentous fungi. To better understand the effects of starvation, we used a parallel plate flow chamber to study individual fungal mycelia when subjected to a step change in glucose concentration. We report the presence of a finite "lag time" in starved mycelia during which they ceased to grow/extend while switching from growth on exogenous carbon to re-growth on endogenous carbon. This lag time precedes other morphological or physiological changes such as change in growth rate (50-70% reduction), vacuolation (up to 16%), and decreased hyphal diameter (almost 50% reduction). Data suggests that during lag time, vacuolar degradation produces sufficient endogenous carbon to support survival and restart hyphal extension. Lag time is inversely related to the size of the mycelium at the time of starvation, which suggests a critical flow of endogenous carbon to the apical tip. We present a mathematical model consistent with our experimental observations that relate lag time, area, and flow of endogenous carbon. (c) 2008 Wiley Periodicals, Inc.

Information-theoretic approach to lead-lag effect on financial markets

NASA Astrophysics Data System (ADS)

Fiedor, Paweł

2014-08-01

Recently the interest of researchers has shifted from the analysis of synchronous relationships of financial instruments to the analysis of more meaningful asynchronous relationships. Both types of analysis are concentrated mostly on Pearson's correlation coefficient and consequently intraday lead-lag relationships (where one of the variables in a pair is time-lagged) are also associated with them. Under the Efficient-Market Hypothesis such relationships are not possible as all information is embedded in the prices, but in real markets we find such dependencies. In this paper we analyse lead-lag relationships of financial instruments and extend known methodology by using mutual information instead of Pearson's correlation coefficient. Mutual information is not only a more general measure, sensitive to non-linear dependencies, but also can lead to a simpler procedure of statistical validation of links between financial instruments. We analyse lagged relationships using New York Stock Exchange 100 data not only on an intraday level, but also for daily stock returns, which have usually been ignored.

Clinical introduction of image lag correction for a cone beam CT system.

PubMed

Stankovic, Uros; Ploeger, Lennert S; Sonke, Jan-Jakob; van Herk, Marcel

2016-03-01

Image lag in the flat-panel detector used for Linac integrated cone beam computed tomography (CBCT) has a degrading effect on CBCT image quality. The most prominent visible artifact is the presence of bright semicircular structure in the transverse view of the scans, known also as radar artifact. Several correction strategies have been proposed, but until now the clinical introduction of such corrections remains unreported. In November 2013, the authors have clinically implemented a previously proposed image lag correction on all of their machines at their main site in Amsterdam. The purpose of this study was to retrospectively evaluate the effect of the correction on the quality of CBCT images and evaluate the required calibration frequency. Image lag was measured in five clinical CBCT systems (Elekta Synergy 4.6) using an in-house developed beam interrupting device that stops the x-ray beam midway through the data acquisition of an unattenuated beam for calibration. A triple exponential falling edge response was fitted to the measured data and used to correct image lag from projection images with an infinite response. This filter, including an extrapolation for saturated pixels, was incorporated in the authors' in-house developed clinical cbct reconstruction software. To investigate the short-term stability of the lag and associated parameters, a series of five image lag measurement over a period of three months was performed. For quantitative analysis, the authors have retrospectively selected ten patients treated in the pelvic region. The apparent contrast was quantified in polar coordinates for scans reconstructed using the parameters obtained from different dates with and without saturation handling. Visually, the radar artifact was minimal in scans reconstructed using image lag correction especially when saturation handling was used. In patient imaging, there was a significant reduction of the apparent contrast from 43 ± 16.7 to 15.5 ± 11.9 HU without the

Clinical introduction of image lag correction for a cone beam CT system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stankovic, Uros; Ploeger, Lennert S.; Sonke, Jan-Jakob, E-mail: j.sonke@nki.nl

Purpose: Image lag in the flat-panel detector used for Linac integrated cone beam computed tomography (CBCT) has a degrading effect on CBCT image quality. The most prominent visible artifact is the presence of bright semicircular structure in the transverse view of the scans, known also as radar artifact. Several correction strategies have been proposed, but until now the clinical introduction of such corrections remains unreported. In November 2013, the authors have clinically implemented a previously proposed image lag correction on all of their machines at their main site in Amsterdam. The purpose of this study was to retrospectively evaluate themore » effect of the correction on the quality of CBCT images and evaluate the required calibration frequency. Methods: Image lag was measured in five clinical CBCT systems (Elekta Synergy 4.6) using an in-house developed beam interrupting device that stops the x-ray beam midway through the data acquisition of an unattenuated beam for calibration. A triple exponential falling edge response was fitted to the measured data and used to correct image lag from projection images with an infinite response. This filter, including an extrapolation for saturated pixels, was incorporated in the authors’ in-house developed clinical CBCT reconstruction software. To investigate the short-term stability of the lag and associated parameters, a series of five image lag measurement over a period of three months was performed. For quantitative analysis, the authors have retrospectively selected ten patients treated in the pelvic region. The apparent contrast was quantified in polar coordinates for scans reconstructed using the parameters obtained from different dates with and without saturation handling. Results: Visually, the radar artifact was minimal in scans reconstructed using image lag correction especially when saturation handling was used. In patient imaging, there was a significant reduction of the apparent contrast from 43 �

Experimental investigation on the effect of plasma jet in the triggered discharge process of a gas switch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tie, W., E-mail: twh.110.666@163.com, E-mail: 84470220@qq.com; Xi'an Jiaotong University, Xi'an 710049; Liu, S.

The temporal and spatial evolution of a plasma jet generated by a spark discharge was observed. The electron temperature and density were obtained under different time and gas pressures by optical emission spectroscopy. Moreover, the discharge process of the plasma-jet triggered gas switch was recorded and analyzed at the lowest working coefficient. The results showed that the plasma jet moved forward in a bullet mode, and the advancing velocity increased with the decrease of pressure, and decreased with time growing. At initial time, the maximum velocity of a plasma jet could reach 3.68 × 10{sup 6 }cm/s. The electron temperature decreased from 2.0 eVmore » to 1.3 eV, and the electron density increased from 3.1 × 10{sup 15}/cm{sup 3} to 6.3 × 10{sup 15}/cm{sup 3} at the initial moment as the gas pressure increases from 0.1 MPa to 0.32 MPa. For a two-gap gas switch, the discharge performances were more depended on the second discharge spark gap (gap 2). Because plasma jet promoted the discharge in Gap 2, the gas switch operating in mode II had better triggered discharge characteristics. In the discharge process, the plasma-jet triggering had the effect of non-penetrating inducing, which not only provided initial electrons for reducing statistical lag but also enhanced the local electric field. The discharge was initiated and accelerated from electron avalanche to streamer. Therefore, a fast discharge was occurred in the gas switch.« less

Far Noise Field of Air Jets and Jet Engines

NASA Technical Reports Server (NTRS)

Callaghan, Edmund E; Coles, Willard D

1957-01-01

An experimental investigation was conducted to study and compare the acoustic radiation of air jets and jet engines. A number of different nozzle-exit shapes were studied with air jets to determine the effect of exit shape on noise generation. Circular, square, rectangular, and elliptical convergent nozzles and convergent-divergent and plug nozzles were investigated. The spectral distributions of the sound power for the engine and the air jet were in good agreement for the case where the engine data were not greatly affected by reflection or jet interference effects. Such power spectra for a subsonic or slightly choked engine or air jet show that the peaks of the spectra occur at a Strouhal number of 0.3.

Granular resistive force theory explains the neuromechanical phase lag during sand-swimming

NASA Astrophysics Data System (ADS)

Ding, Yang; Sharpe, Sarah; Goldman, Daniel

2012-11-01

Undulatory locomotion is a common gait used by a diversity of animals in a range of environments. This mode of locomotion is characterized by the propagation of a traveling wave of body bending, which propels the animal in the opposite direction of the wave. Previous studies of undulatory locomotion in fluids, on land, and even within sand revealed that the wave of muscle activation progresses faster than the traveling wave of curvature. This leads to an increasing phase lag between activation and curvature at more posterior segments, known as the neuromechanical phase lag. In this study, we compare biological measurements of phase lag during the sand-swimming of the sandfish lizard to predictions of a simple model of undulatory swimming that consists of prescribed kinematics and granular resistive forces. The neuromechanical phase lag measured using electromyography (EMG) quantitatively matches the predicted phase lag between the local body curvature and torque exerted by granular resistive forces. Two effects are responsible for the phase lag in this system: the yaw motion of the body and different integration length over a traveling force pattern for different positions along the body.

Stretched Inertial Jets

NASA Astrophysics Data System (ADS)

Ghabache, Elisabeth; Antkowiak, Arnaud; Seon, Thomas; Villermaux, Emmanuel

2015-11-01

Liquid jets often arise as short-lived bursting liquid flows. Cavitation or impact-driven jets, bursting champagne bubbles, shaped-charge jets, ballistospores or drop-on-demand inkjet printing are a few examples where liquid jets are suddenly released. The trademark of all these discharge jets is the property of being stretched, due to the quenching injection. the present theoretical and experimental investigation, the structure of the jet flow field will be unraveled experimentally for a few emblematic occurrences of discharge jets. Though the injection markedly depends on each flow configuration, the jet velocity field will be shown to be systematically and rapidly attracted to the universal stretching flow z/t. The emergence of this inertial attractor actually only relies on simple kinematic ingredients, and as such is fairly generic. The universality of the jet velocity structure will be discussed.

Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance.

PubMed

D'Elia, Riccardo; Allen, Patricia L; Johanson, Kelly; Nickerson, Cheryl A; Hammond, Timothy G

2005-06-01

This study identifies genes that determine length of lag phase, using the model eukaryotic organism, Saccharomyces cerevisiae. We report growth of a yeast deletion series following variations in the lag phase induced by variable storage times after drying-down yeast on filters. Using a homozygous diploid deletion pool, lag times ranging from 0 h to 90 h were associated with increased drop-out of mitochondrial genes and increased survival of nuclear genes. Simple linear regression (R2 analysis) shows that there are over 500 genes for which > 70% of the variation can be explained by lag alone. In the genes with a positive correlation, such that the gene abundance increases with lag and hence the deletion strain is suitable for survival during prolonged storage, there is a strong predominance of nucleonic genes. In the genes with a negative correlation, such that the gene abundance decreases with lag and hence the strain may be critical for getting yeast out of the lag phase, there is a strong predominance of glycoproteins and transmembrane proteins. This study identifies yeast deletion strains with survival advantage on prolonged storage and amplifies our understanding of the genes critical for getting out of the lag phase.

Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance

NASA Technical Reports Server (NTRS)

D'Elia, Riccardo; Allen, Patricia L.; Johanson, Kelly; Nickerson, Cheryl A.; Hammond, Timothy G.

2005-01-01

This study identifies genes that determine length of lag phase, using the model eukaryotic organism, Saccharomyces cerevisiae. We report growth of a yeast deletion series following variations in the lag phase induced by variable storage times after drying-down yeast on filters. Using a homozygous diploid deletion pool, lag times ranging from 0 h to 90 h were associated with increased drop-out of mitochondrial genes and increased survival of nuclear genes. Simple linear regression (R2 analysis) shows that there are over 500 genes for which > 70% of the variation can be explained by lag alone. In the genes with a positive correlation, such that the gene abundance increases with lag and hence the deletion strain is suitable for survival during prolonged storage, there is a strong predominance of nucleonic genes. In the genes with a negative correlation, such that the gene abundance decreases with lag and hence the strain may be critical for getting yeast out of the lag phase, there is a strong predominance of glycoproteins and transmembrane proteins. This study identifies yeast deletion strains with survival advantage on prolonged storage and amplifies our understanding of the genes critical for getting out of the lag phase.

SOFT LAGS IN NEUTRON STAR kHz QUASI-PERIODIC OSCILLATIONS: EVIDENCE FOR REVERBERATION?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barret, Didier, E-mail: didier.barret@irap.omp.eu; CNRS, Institut de Recherche en Astrophysique et Planetologie, 9 Av. colonel Roche, BP 44346, F-31028 Toulouse cedex 4

2013-06-10

High frequency soft reverberation lags have now been detected from stellar mass and supermassive black holes. Their interpretation involves reflection of a hard source of photons onto an accretion disk, producing a delayed reflected emission, with a time lag consistent with the light travel time between the irradiating source and the disk. Independently of the location of the clock, the kHz quasi-periodic oscillation (QPO) emission is thought to arise from the neutron star boundary layer. Here, we search for the signature of reverberation of the kHz QPO emission, by measuring the soft lags and the lag energy spectrum of themore » lower kHz QPOs from 4U1608-522. Soft lags, ranging from {approx}15 to {approx}40 {mu}s, between the 3-8 keV and 8-30 keV modulated emissions are detected between 565 and 890 Hz. The soft lags are not constant with frequency and show a smooth decrease between 680 Hz and 890 Hz. The broad band X-ray spectrum is modeled as the sum of a disk and a thermal Comptonized component, plus a broad iron line, expected from reflection. The spectral parameters follow a smooth relationship with the QPO frequency, in particular the fitted inner disk radius decreases steadily with frequency. Both the bump around the iron line in the lag energy spectrum and the consistency between the lag changes and the inferred changes of the inner disk radius, from either spectral fitting or the QPO frequency, suggest that the soft lags may indeed involve reverberation of the hard pulsating QPO source on the disk.« less

Factorization for jet radius logarithms in jet mass spectra at the LHC

DOE PAGES

Kolodrubetz, Daniel W.; Pietrulewicz, Piotr; Stewart, Iain W.; ...

2016-12-14

To predict the jet mass spectrum at a hadron collider it is crucial to account for the resummation of logarithms between the transverse momentum of the jet and its invariant mass m J . For small jet areas there are additional large logarithms of the jet radius R, which affect the convergence of the perturbative series. We present an analytic framework for exclusive jet production at the LHC which gives a complete description of the jet mass spectrum including realistic jet algorithms and jet vetoes. It factorizes the scales associated with m J , R, and the jet veto, enablingmore » in addition the systematic resummation of jet radius logarithms in the jet mass spectrum beyond leading logarithmic order. We discuss the factorization formulae for the peak and tail region of the jet mass spectrum and for small and large R, and the relations between the different regimes and how to combine them. Regions of experimental interest are classified which do not involve large nonglobal logarithms. We also present universal results for nonperturbative effects and discuss various jet vetoes.« less

Time-lagged response of the Antarctic atmosphere to tropical MJO convection

NASA Astrophysics Data System (ADS)

Henderson, G. R.; Barrett, B.

2017-12-01

Intraseasonal tropical climate variability has important implications on mid- and high- latitude climate, and in recent studies has been shown to modulate a number of weather processes in the Northern Hemisphere, such as snow depth, sea ice concentration, precipitation, atmospheric rivers, and air temperature. In such studies, the leading mode of tropical intraseasonal variability, the Madden-Julian Oscillation (MJO), has tended to lag tropical convection by approximately 7 days. However, no such consensus exists when considering the relationship and lag between the MJO and the Antarctic atmosphere. This study builds on previous work by further examining the time-lagged response of Southern Hemisphere tropospheric circulation to tropical MJO forcing, with specific focus on the latitude belt associated with the Antarctic Oscillation, during the months of June (Austral winter) and December (Austral summer) using NCEP-DOE Reanalysis 2 data for the years 1970-2016. Principal findings indicate that the time lag with strongest height anomalies depends on both the location of the MJO convection (e.g., the MJO phase) and the season, and that the lagged height anomalies in the Antarctic atmosphere are fairly consistent across different vertical levels and latitudinal bands. In addition, certain MJO phases in December displayed lagged height anomalies indicative of blocking-type atmospheric patterns, with an approximate wavenumber of 4, whereas in June most phases were associated with progressive height anomaly centers displaying a wavenumber-3 type pattern.

Staying Healthy While You Travel (For Parents)

MedlinePlus

... ear discomfort , travel (or motion) sickness, and diarrhea . Jet Lag When you fly across time zones, it ... for longer than usual. In addition to tiredness, jet lag can also cause an upset stomach and ...

LagLoc - a new surgical technique for locking plate systems.

PubMed

Triana, Miguel; Gueorguiev, Boyko; Sommer, Christoph; Stoffel, Karl; Agarwal, Yash; Zderic, Ivan; Helfen, Tobias; Krieg, James C; Krause, Fabian; Knobe, Matthias; Richards, R Geoff; Lenz, Mark

2018-06-19

Treatment of oblique and spiral fractures remains challenging. The aim of this study was to introduce and investigate the new LagLoc technique for locked plating with generation of interfragmentary compression, combining the advantages of lag-screw and locking-head-screw techniques. Oblique fracture was simulated in artificial diaphyseal bones, assigned to three groups for plating with a 7-hole locking compression plate. Group I was plated with three locking screws in holes 1, 4 and 7. The central screw crossed the fracture line. In group II the central hole was occupied with a lag screw perpendicular to fracture line. Group III was instrumented applying the LagLoc technique as follows. Hole 4 was predrilled perpendicularly to the plate, followed by overdrilling of the near cortex and insertion of a locking screw whose head was covered by a holding sleeve to prevent temporarily the locking in the plate hole and generate interfragmentary compression. Subsequently, the screw head was released and locked in the plate hole. Holes 1 and 7 were occupied with locking screws. Interfragmentary compression in the fracture gap was measured using pressure sensors. All screws in the three groups were tightened with 4Nm torque. Interfragmentary compression in group I (167 ± 25N) was significantly lower in comparison to groups II (431 ± 21N) and III (379 ± 59N), p≤0.005. The difference in compression between groups II and III remained not significant (p = 0.999). The new LagLoc technique offers an alternative tool to generate interfragmentary compression with the application of locking plates by combining the biomechanical advantages of lag screw and locking screw fixations. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Time lag and communication in changing unpopular norms.

PubMed

Gërxhani, Klarita; Bruggeman, Jeroen

2015-01-01

Humans often coordinate their social lives through norms. When a large majority of people are dissatisfied with an existing norm, it seems obvious that they will change it. Often, however, this does not occur. We investigate how a time lag between individual support of a norm change and the change itself hinders such change, related to the critical mass of supporters needed to effectuate the change, and the (im)possibility of communicating about it. To isolate these factors, we utilize a laboratory experiment. As predicted, we find unambiguous effects of time lag on precluding norm change; a higher threshold for a critical mass does so as well. Communication facilitates choosing superior norms but it does not necessarily lead to norm change when the uncertainty on whether there will be a norm change in the future is high. Communication seems to help coordination on actions at the present but not the future. Hence, the uncertainty driven by time lag makes individuals choose the status quo, here the unpopular norm.

Time Lag and Communication in Changing Unpopular Norms

PubMed Central

Gërxhani, Klarita; Bruggeman, Jeroen

2015-01-01

Humans often coordinate their social lives through norms. When a large majority of people are dissatisfied with an existing norm, it seems obvious that they will change it. Often, however, this does not occur. We investigate how a time lag between individual support of a norm change and the change itself hinders such change, related to the critical mass of supporters needed to effectuate the change, and the (im)possibility of communicating about it. To isolate these factors, we utilize a laboratory experiment. As predicted, we find unambiguous effects of time lag on precluding norm change; a higher threshold for a critical mass does so as well. Communication facilitates choosing superior norms but it does not necessarily lead to norm change when the uncertainty on whether there will be a norm change in the future is high. Communication seems to help coordination on actions at the present but not the future. Hence, the uncertainty driven by time lag makes individuals choose the status quo, here the unpopular norm. PMID:25880200

Shear-lag analysis about an internally-dropped ply

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vizzini, A.J.

1995-12-31

The region around a terminated ply is modeled as several elastic layers separated by shear regions. A shear-lag analysis is then performed allowing for the thickness of the elastic and shear layers to vary. Boundary conditions, away for the ply drop, are based on the deflections determined by a finite element model. The interlaminar stresses are compared against those generated by the finite element model for tapered laminates under pure extension, pure bending, and extension-bending coupling. The shear-lag analysis predicts the interlaminar shear at and near the ply drop for pure extension and in cases involving bending if the deflectionsmore » due to bending are removed. The interlaminar shear stress and force equilibrium are used to determine the interlaminar normal stress. The trends in the interlaminar normal stress shown by the finite element model are partially captured by the shear-lag analysis. This simple analysis indicates that the mechanism for load transfer about a ply drop is primarily due to shear transfer through the resin rich areas.« less

An evaluation of the lag of accommodation using photorefraction.

PubMed

Seidemann, Anne; Schaeffel, Frank

2003-02-01

The lag of accommodation which occurs in most human subjects during reading has been proposed to explain the association between reading and myopia. However, the measured lags are variable among different published studies and current knowledge on its magnitude rests largely on measurements with the Canon R-1 autorefractor. Therefore, we have measured it with another technique, eccentric infrared photorefraction (the PowerRefractor), and studied how it can be modified. Particular care was taken to ensure correct calibration of the instrument. Ten young adult subjects were refracted both in the fixation axis of the right eye and from the midline between both eyes, while they read text both monocularly and binocularly at 1.5, 2, 3, 4 and 5 D distance ("group 1"). A second group of 10 subjects ("group 2"), measured from the midline between both eyes, was studied to analyze the effects of binocular vs monocular vision, addition of +1 or +2 D lenses, and of letter size. Spherical equivalents (SE) were analyzed in all cases. The lag of accommodation was variable among subjects (standard deviations among groups and viewing distances ranging from 0.18 to 1.07 D) but was significant when the measurements were done in the fixation axis (0.35 D at 3 D target distance to 0.60 D at 5 D with binocular vision; p<0.01 or better all cases). Refracting from the midline between both eyes tended to underestimate the lag of accommodation although this was significant only at 5 D (ANOVA: p<0.0001, post hoc t-test: p<0.05). There was a small improvement in accommodation precision with binocular compared to monocular viewing but significance was reached only for the 5 D reading target (group 1--lags for a 3/4/5 D target: 0.35 vs 0.41 D/0.48 vs 0.47 D/0.60 vs 0.66 D, ANOVA: p<0.0001, post hoc t-test: p<0.05; group 2--0.29 vs 0.12 D, 0.33 vs 0.16 D, 0.23 vs -0.31 D, ANOVA: p<0.0001, post hoc t-test: p<0.05). Adjusting the letter height for constant angular subtense (0.2 deg) induced

Synthetic Jets in Cross-flow. Part 1; Round Jet

NASA Technical Reports Server (NTRS)

Zaman, K. B. M. Q.; Milanovic, Ivana M.

2003-01-01

Results of an experimental investigation on synthetic jets from round orifices with and without cross-flow are presented. Jet Reynolds number up to 46,000 with a fully turbulent approach boundary layer, and Stokes number up to 400. are covered. The threshold of stroke length for synthetic jet formation. in the absence of the cross-flow, is found to be Lo /D approximately 0.5. Above Lo /D is approximately 10, the profiles of normalized centerline mean velocity appear to become invariant. It is reasoned that the latter threshold may be related to the phenomenon of saturation of impulsively generated vortices. In the presence of the cross-flow, the penetration height of a synthetic jet is found to depend on the momentum- flux ratio . When this ratio is defined in terms of the maximum jet velocity and the cross-flow velocity. not only all data collapse but also the jet trajectory is predicted well by correlation equation available for steady jets-in-cross-flow. Distributions of mean velocity, streamwise vorticity as well as turbulence intensity for a synthetic jet in cross-flow are found to be similar to those of a steady jet-in-cross-flow. A pair of counter-rotating streamwise vortices, corresponding to the bound vortex pair of the steady case, is clearly observed. Mean velocity distribution exhibits a dome of low momentum fluid pulled up from the boundary layer, and the entire domain is characterized by high turbulence.

Multiple jet study data correlations. [data correlation for jet mixing flow of air jets

NASA Technical Reports Server (NTRS)

Walker, R. E.; Eberhardt, R. G.

1975-01-01

Correlations are presented which allow determination of penetration and mixing of multiple cold air jets injected normal to a ducted subsonic heated primary air stream. Correlations were obtained over jet-to-primary stream momentum flux ratios of 6 to 60 for locations from 1 to 30 jet diameters downstream of the injection plane. The range of geometric and operating variables makes the correlations relevant to gas turbine combustors. Correlations were obtained for the mixing efficiency between jets and primary stream using an energy exchange parameter. Also jet centerplane velocity and temperature trajectories were correlated and centerplane dimensionless temperature distributions defined. An assumption of a Gaussian vertical temperature distribution at all stations is shown to result in a reasonable temperature field model. Data are presented which allow comparison of predicted and measured values over the range of conditions specified above.

The shear-lag effect of thin-walled box girder under vertical earthquake excitation

NASA Astrophysics Data System (ADS)

Zhai, Zhipeng; Li, Yaozhuang; Guo, Wei

2017-03-01

The variation method based on the energy variation principle is proved to be accurate and valid for analyzing the shear lag effect of box girder under static and dynamic load. Meanwhile, dynamic problems gradually become the key factors in engineering practice. Therefore, a method for calculating the shear lag effect in thin-walled box girder under vertical seismic excitation is proposed by applying Hamilton Principle in this paper. The Timoshenko shear deformation is taken into account. And a new definition of shear lag ratio for box girder is given. What's more, some conclusions are drawn by analysis of numerical example. The results show that small amplitude of earthquake ground motion can generate high stress and obvious shear lag, especially in the region of resonance. And the influence of rotary inertia cannot be ignored for analyzing the shear lag effect. With the increase of span to width ratio, shear lag effect becomes smaller and smaller. These research conclusions will be useful for the engineering practice and enrich the theoretical studies of box girders.

A nonlinear lag correction algorithm for a-Si flat-panel x-ray detectors

PubMed Central

Starman, Jared; Star-Lack, Josh; Virshup, Gary; Shapiro, Edward; Fahrig, Rebecca

2012-01-01

Purpose: Detector lag, or residual signal, in a-Si flat-panel (FP) detectors can cause significant shading artifacts in cone-beam computed tomography reconstructions. To date, most correction models have assumed a linear, time-invariant (LTI) model and correct lag by deconvolution with an impulse response function (IRF). However, the lag correction is sensitive to both the exposure intensity and the technique used for determining the IRF. Even when the LTI correction that produces the minimum error is found, residual artifact remains. A new non-LTI method was developed to take into account the IRF measurement technique and exposure dependencies. Methods: First, a multiexponential (N = 4) LTI model was implemented for lag correction. Next, a non-LTI lag correction, known as the nonlinear consistent stored charge (NLCSC) method, was developed based on the LTI multiexponential method. It differs from other nonlinear lag correction algorithms in that it maintains a consistent estimate of the amount of charge stored in the FP and it does not require intimate knowledge of the semiconductor parameters specific to the FP. For the NLCSC method, all coefficients of the IRF are functions of exposure intensity. Another nonlinear lag correction method that only used an intensity weighting of the IRF was also compared. The correction algorithms were applied to step-response projection data and CT acquisitions of a large pelvic phantom and an acrylic head phantom. The authors collected rising and falling edge step-response data on a Varian 4030CB a-Si FP detector operating in dynamic gain mode at 15 fps at nine incident exposures (2.0%–92% of the detector saturation exposure). For projection data, 1st and 50th frame lag were measured before and after correction. For the CT reconstructions, five pairs of ROIs were defined and the maximum and mean signal differences within a pair were calculated for the different exposures and step-response edge techniques. Results: The LTI

Why does lag affect the durability of memory-based automaticity: loss of memory strength or interference?

PubMed

Wilkins, Nicolas J; Rawson, Katherine A

2013-10-01

In Rickard, Lau, and Pashler's (2008) investigation of the lag effect on memory-based automaticity, response times were faster and proportion of trials retrieved was higher at the end of practice for short lag items than for long lag items. However, during testing after a delay, response times were slower and proportion of trials retrieved was lower for short lag items than for long lag items. The current study investigated the extent to which the lag effect on the durability of memory-based automaticity is due to interference or to the loss of memory strength with time. Participants repeatedly practiced alphabet subtraction items in short lag and long lag conditions. After practice, half of the participants were immediately tested and the other half were tested after a 7-day delay. Results indicate that the lag effect on the durability of memory-based automaticity is primarily due to interference. We discuss potential modification of current memory-based processing theories to account for these effects. © 2013.

Active Region Jets II: Triggering and Evolution of Violent Jets

NASA Astrophysics Data System (ADS)

Sterling, Alphonse C.; Moore, Ronald L.; Falconer, David; Panesar, Navdeep K.; Martinez, Francisco

2017-08-01

We study a series of X-ray-bright, rapidly evolving active-region coronal jets outside the leading sunspot of AR 12259, using Hinode/XRT, SDO/AIA and HMI, and IRIS/SJ data. The detailed evolution of such rapidly evolving “violent” jets remained a mystery after our previous investigation of active region jets (Sterling et al. 2016, ApJ, 821, 100). The jets we investigate here erupt from three localized subregions, each containing a rapidly evolving (positive) minority-polarity magnetic-flux patch bathed in a (majority) negative-polarity magnetic-flux background. At least several of the jets begin with eruptions of what appear to be thin (thickness ˜<2‧‧) miniature-filament (minifilament) “strands” from a magnetic neutral line where magnetic flux cancelation is ongoing, consistent with the magnetic configuration presented for coronal-hole jets in Sterling et al. (2015, Nature, 523, 437). For some jets strands are difficult/ impossible to detect, perhaps due to their thinness, obscuration by surrounding bright or dark features, or the absence of erupting cool-material minifilaments in those jets. Tracing in detail the flux evolution in one of the subregions, we find bursts of strong jetting occurring only during times of strong flux cancelation. Averaged over seven jetting episodes, the cancelation rate was ~1.5×10^19 Mx/hr. An average flux of ~5×10^18 Mx canceled prior to each episode, arguably building up ~10^28—10^29 ergs of free magnetic energy per jet. From these and previous observations, we infer that flux cancelation is the fundamental process responsible for the pre-eruption buildup and triggering of at least many jets in active regions, quiet regions, and coronal holes.

Active control of continuous air jet with bifurcated synthetic jets

NASA Astrophysics Data System (ADS)

Dančová, Petra; Vít, Tomáš; Jašíková, Darina; Novosád, Jan

The synthetic jets (SJs) have many significant applications and the number of applications is increasing all the time. In this research the main focus is on the primary flow control which can be used effectively for the heat transfer increasing. This paper deals with the experimental research of the effect of two SJs worked in the bifurcated mode used for control of an axisymmetric air jet. First, the control synthetic jets were measured alone. After an adjustment, the primary axisymmetric jet was added in to the system. For comparison, the primary flow without synthetic jets control was also measured. All experiments were performed using PIV method whereby the synchronization between synthetic jets and PIV system was necessary to do.

Accommodative Lag by Autorefraction and Two Dynamic Retinoscopy Methods

PubMed Central

2008-01-01

Purpose To evaluate two clinical procedures, MEM and Nott retinoscopy, for detecting accommodative lags 1.00 diopter (D) or greater in children as identified by an open-field autorefractor. Methods 168 children 8 to <12 years old with low myopia, normal visual acuity, and no strabismus participated as part of an ancillary study within the screening process for a randomized trial. Accommodative response to a 3.00 D demand was first assessed by MEM and Nott retinoscopy, viewing binocularly with spherocylindrical refractive error corrected, with testing order randomized and each performed by a different masked examiner. The response was then determined viewing monocularly with spherical equivalent refractive error corrected, using an open-field autorefractor, which was the gold standard used for eligibility for the clinical trial. Sensitivity and specificity for accommodative lags of 1.00 D or more were calculated for each retinoscopy method compared to the autorefractor. Results 116 (69%) of the 168 children had accommodative lag of 1.00 D or more by autorefraction. MEM identified 66 children identified by autorefraction for a sensitivity of 57% (95% CI = 47% to 66%) and a specificity of 63% (95% CI = 49% to 76%). Nott retinoscopy identified 35 children for a sensitivity of 30% (95% CI = 22% to 39%) and a specificity of 81% (95% CI = 67% to 90%). Analysis of receiver operating characteristic (ROC) curves constructed for MEM and for Nott retinoscopy failed to reveal alternate cut points that would improve the combination of sensitivity and specificity for identifying accommodative lag ≥ 1.00 D as defined by autorefraction. Conclusions Neither MEM nor Nott retinoscopy provided adequate sensitivity and specificity to identify myopic children with accommodative lag ≥ 1.00 D as determined by autorefraction. A variety of methodological differences between the techniques may contribute to the modest to poor agreement. PMID:19214130

Intra-jet shocks in two counter-streaming, weakly collisional plasma jets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryutov, D. D.; Kugland, N. L.; Park, H.-S.

2012-07-15

Counterstreaming laser-generated plasma jets can serve as a test-bed for the studies of a variety of astrophysical phenomena, including collisionless shock waves. In the latter problem, the jet's parameters have to be chosen in such a way as to make the collisions between the particles of one jet with the particles of the other jet very rare. This can be achieved by making the jet velocities high and the Coulomb cross-sections correspondingly low. On the other hand, the intra-jet collisions for high-Mach-number jets can still be very frequent, as they are determined by the much lower thermal velocities of themore » particles of each jet. This paper describes some peculiar properties of intra-jet hydrodynamics in such a setting: the steepening of smooth perturbations and shock formation affected by the presence of the 'stiff' opposite flow; the role of a rapid electron heating in shock formation; ion heating by the intrajet shock. The latter effect can cause rapid ion heating which is consistent with recent counterstreaming jet experiments by Ross et al.[Phys. Plasmas 19, 056501 (2012)].« less

Rapid Confined Mixing Using Transverse Jets Part 2: Multiple Jets

NASA Astrophysics Data System (ADS)

Forliti, David; Salazar, David

2012-11-01

An experimental study has been conducted at the Air Force Research Laboratory at Edwards Air Force Base to investigate the properties of confined mixing devices that employ transverse jets. The experiment considers the mixing of water with a mixture of water and fluorescein, and planar laser induced fluorescence was used to measure instantaneous mixture fraction distributions in the cross section view. Part one of this study presents the scaling law development and results for a single confined transverse jet. Part two will describe the results of configurations including multiple transverse jets. The different regimes of mixing behavior, ranging from under to overpenetration of the transverse jets, are characterized in terms of a new scaling law parameter presented in part one. The level of unmixedness, a primary metric for mixing device performance, is quantified for different jet diameters, number of jets, and relative flow rates. It is apparent that the addition of a second transverse jet provides enhanced scalar uniformity in the main pipe flow cross section compared to a single jet. Three and six jet configurations also provide highly uniform scalar distributions. Turbulent scalar fluctuation intensities, spectral features, and spatial eigenfunctions using the proper orthogonal decomposition will be presented. Distribution A: Public Release, Public Affairs Clearance Number: 12656.

Turbulence measurements in axisymmetric jets of air and helium. I - Air jet. II - Helium jet

NASA Technical Reports Server (NTRS)

Panchapakesan, N. R.; Lumley, J. L.

1993-01-01

Results are presented of measurements on turbulent round jets of air and of helium of the same nozzle momentum efflux, using, for the air jets, x-wire hot-wire probes mounted on a moving shuttle and, for He jets, a composite probe consisting of an interference probe of the Way-Libby type and an x-probe. Current models for scalar triple moments were evaluated. It was found that the performance of the model termed the Full model, which includes all terms except advection, was very good for both the air and the He jets.

49 CFR 230.64 - Leaks under lagging.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Boilers and Appurtenances Steam Leaks § 230.64 Leaks under lagging. The steam locomotive owner and/or operator shall take out of...

Aeromechanical stability augmentation using semi-active friction-based lead-lag damper

NASA Astrophysics Data System (ADS)

Agarwal, Sandeep

2005-11-01

Lead-lag dampers are present in most rotors to provide the required level of damping in all flight conditions. These dampers are a critical component of the rotor system, but they also represent a major source of maintenance cost. In present rotor systems, both hydraulic and elastomeric lead-lag dampers have been used. Hydraulic dampers are complex mechanical components that require hydraulic fluids and have high associated maintenance costs. Elastomeric dampers are conceptually simpler and provide a "dry" rotor, but are rather costly. Furthermore, their damping characteristics can degrade with time without showing external signs of failure. Hence, the dampers must be replaced on a regular basis. A semi-active friction based lead-lag damper is proposed as a replacement for hydraulic and elastomeric dampers. Damping is provided by optimized energy dissipation due to frictional forces in semi-active joints. An actuator in the joint modulates the normal force that controls energy dissipation at the frictional interfaces, resulting in large hysteretic loops. Various selective damping strategies are developed and tested for a simple system containing two different frequency modes in its response, one of which needs to be damped out. The system reflects the situation encountered in rotor response where 1P excitation is present along with the potentially unstable regressive lag motion. Simulation of the system response is obtained to compare their effectiveness. Next, a control law governing the actuation in the lag damper is designed to generate the desired level of damping for performing adaptive selective damping of individual blade lag motion. Further, conceptual design of a piezoelectric friction based lag damper for a full-scale rotor is presented and various factors affecting size, design and maintenance cost, damping capacity, and power requirements of the damper are discussed. The selective semi-active damping strategy is then studied in the context of classical

Spiral jet

NASA Astrophysics Data System (ADS)

Istomin, Ya N.

2018-05-01

We show that a quasi-cylindrical configuration of a jet in the central region, where direct electric current flows, is confined in a radial equilibrium by a spiral wave at the periphery of a jet. A spiral wave means that in a coordinate system moving with the velocity of the matter along the axis of the jet, all quantities are proportional to exp {ik∥z + imϕ}, z is the longitudinal coordinate, and ϕ is the azimuthal angle. The luminosity of such a jet corresponds to observations. It is also shown that the jet slowly expands with distance z from its base by the power law, R(z) ∝ zk, where the exponent k varies from ≃0.5 to ≃1.

Lead-Lag Control for Helicopter Vibration and Noise Reduction

NASA Technical Reports Server (NTRS)

Gandhi, Farhan

1995-01-01

. Both schemes cause an increase in pitch link loads. Trailing Edge Flap (TEF) deployment can also used to generate unsteady aerodynamic forces and moments that counter the original vibratory loads, and thereby reduce rotor vibrations. While the vibrations absorbers, HHC, IBC, and TEF concepts discussed above attempt to reduce the vibratory loads, they do not specifically address the phenomena causing the vibrations at high advance ratios. One passive method that attempts to directly alleviate compressibility and stall, instead of reducing the ensuing vibrations, is the use of advanced tip designs. Taper, sweep, anhedral, and the manipulation of other geometric properties of the blade tips can reduce the severity of stall and compressibility effects , as well as reduce rotor power. A completely different approach to solve these problems is the tiltrotor configuration. As the forward velocity of the aircraft increases, the rotors, in this case, are tilted forward until they are perpendicular to the flow and act as propellers. This eliminates the edgewise flow encountered by conventional rotors and circumvents all the problems associated with flow asymmetry. However, the success involves a tremendous increase in cost and complexity of the aircraft. Another possible approach that has been proposed for the alleviation of vibratory loads at high forward flight speeds involves the use of controlled lead-lag motions to reduce the asymmetry in flow. A correctly phased 1/rev controlled lag motion could be introduced such that it produces a backward velocity on the advancing side and a forward velocity on the retreating side, to delay compressibility effects and stall to a higher advance ratio. Using a large enough lead-lag amplitude, the tip velocities could be reduced to levels encountered in hover. This concept was examined by two groups in the 1950's and early 1960's. In the United States, the Research Labs Division of United Aircraft developed a large lead-lag motion rotor

Influence of several factors on ignition lag in a compression-ignition engine

NASA Technical Reports Server (NTRS)

Gerrish, Harold C; Voss, Fred

1932-01-01

This investigation was made to determine the influence of fuel quality, injection advance angle, injection valve-opening pressure, inlet-air pressure, compression ratio, and engine speed on the time lag of auto-ignition of a Diesel fuel oil in a single-cylinder compression-ignition engine as obtained from an analysis of indicator diagrams. Three cam-operated fuel-injection pumps, two pumps cams, and an automatic injection valve with two different nozzles were used. Ignition lag was considered to be the interval between the start of injection of the fuel as determined with a Stroborama and the start of effective combustion as determined from the indicator diagram, the latter being the point where 4.0 x 10(exp-6) pound of fuel had been effectively burned. For this particular engine and fuel it was found that: (1) for a constant start and the same rate of fuel injection up the point of cut-off, a variation in fuel quantity from 1.2 x 10(exp-4) to 4.1 x 10(exp-4) pound per cycle has no appreciable effect on the ignition lag; (2) injection advance angle increases or decreases the lag according to whether density, temperature, or turbulence has the controlling influence; (3) increase in valve-opening pressure slightly increases the lag; and (4) increase of inlet-air pressure, compression ratio, and engine speed reduces the lag.

Multi-frequency properties of synthetic blazar radio light curves within the shock-in-jet scenario

NASA Astrophysics Data System (ADS)

Fromm, C. M.; Fuhrmann, L.; Perucho, M.

2015-08-01

Context. Blazars are among the most powerful extragalactic objects as a sub-class of active galactic nuclei. They launch relativistic jets and their emitted radiation shows strong variability across the entire electro-magnetic spectrum. The mechanisms producing the variability are still controversial, and different models have been proposed to explain the observed variations in multi-frequency blazar light curves. Aims: We investigate the capabilities of the classical shock-in-jet model to explain and reconstruct the observed evolution of flares in the turnover frequency - turnover flux density (νm-Sm) plane and their frequency dependent light curve parameters. With a detailed parameter space study, we provide the framework for future, detailed comparisons of observed flare signatures with the shock-in-jet scenario. Methods: Based on the shock model, we compute synthetic single-dish light curves at different radio frequencies (2.6 to 345 GHz) and for different physical conditions in a conical jet (e.g. magnetic field geometry and Doppler factor). From those we extract the slopes of the different energy loss stages within the (νm-Sm) plane and deduce the frequency dependence of different light curve parameters, such as flare amplitude, time scale, and cross-band delays. Results: The evolution of the Doppler factor along the jet has the strongest influence on the evolution of the flare and on the frequency dependent light curve parameters. The synchrotron stage can be hidden in the Compton or in the adiabatic stage, depending mainly on the evolution of the Doppler factor, which makes it difficult to detect its signature in observations. In addition, we show that the time lags between different frequencies can be used as an efficient tool to better constrain the physical properties of these objects. Appendix A is available in electronic form at http://www.aanda.org

Rapid Confined Mixing with Transverse Jets Part 1: Single Jet

NASA Astrophysics Data System (ADS)

Salazar, David; Forliti, David

2012-11-01

Transverse jets have been studied extensively due to their relevance and efficiency in fluid mixing applications. Gas turbine burners, film cooling, and chemical reactors are some examples of rapid transverse jet mixing. Motivated by a lack of universal scaling laws for confined and unconfined transverse jets, a newly developed momentum transfer parameter was found to improve correlation of literature data. Jet column drag and entrainment arguments for momentum transfer are made to derive the parameter. A liquid-phase mixing study was conducted to investigate confined mixing for a low number of jets. Planar laser induced fluorescence was implemented to measure mixture fraction for a single confined transverse jet. Time-averaged cross-sectional images were taken with a light sheet located three diameters downstream of transverse injection. A mixture of water and sodium fluorescein was used to distinguish jet fluid from main flow fluid for the test section images. Image data suggest regimes for under- and overpenetration of jet fluid into the main flow. The scaling parameter is found to correlate optimum unmixedness for multiple diameter ratios at a parameter value of 0.75. Distribution A: Public Release, Public Affairs Clearance Number: 12655.

Effects of ramelteon on insomnia symptoms induced by rapid, eastward travel.

PubMed

Zee, Phyllis C; Wang-Weigand, Sherry; Wright, Kenneth P; Peng, Xuejun; Roth, Thomas

2010-06-01

Ramelteon, an MT(1)/MT(2) melatonin receptor agonist, was evaluated for its ability to reduce sleep-onset difficulties associated with eastward jet travel. Healthy adults (n=110) with a history of jet lag sleep disturbances were flown eastward across five time zones from Hawaii to the east coast of the US. Ramelteon 1, 4, or 8 mg or placebo was administered 5 min before bedtime (local time) for four nights. Sleep parameters were measured using polysomnography (PSG) on Nights 2, 3, and 4. Next-day residual effects were assessed using psychomotor and memory function tests. Compared to placebo, there was a significant decrease in mean latency to persistent sleep (LPS) on Nights 2-4 with ramelteon 1mg (-10.64 min, P=0.030). No consistent significant differences were observed with ramelteon vs. placebo on measures of next-day residual effects except on Day 4 where participants in all ramelteon groups performed significantly worse on the immediate memory recall test compared with placebo (P < or = 0.05). The incidence of adverse events was similar for ramelteon and placebo. After a 5-h phase advance due to eastward jet travel, ramelteon 1mg taken before bedtime for four nights reduced mean LPS relative to placebo in healthy adults. Copyright 2010 Elsevier B.V. All rights reserved.

Understanding jet noise.

PubMed

Karabasov, S A

2010-08-13

Jets are one of the most fascinating topics in fluid mechanics. For aeronautics, turbulent jet-noise modelling is particularly challenging, not only because of the poor understanding of high Reynolds number turbulence, but also because of the extremely low acoustic efficiency of high-speed jets. Turbulent jet-noise models starting from the classical Lighthill acoustic analogy to state-of-the art models were considered. No attempt was made to present any complete overview of jet-noise theories. Instead, the aim was to emphasize the importance of sound generation and mean-flow propagation effects, as well as their interference, for the understanding and prediction of jet noise.

Constraining Anisotropic Lorentz Violation via the Spectral-lag Transition of GRB 160625B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wei, Jun-Jie; Wu, Xue-Feng; Shao, Lang

Violations of Lorentz invariance can lead to an energy-dependent vacuum dispersion of light, which results in arrival-time differences of photons with different energies arising from a given transient source. In this work, direction-dependent dispersion constraints are obtained on nonbirefringent Lorentz-violating effects using the observed spectral lags of the gamma-ray burst GRB 160625B. This burst has unusually large high-energy photon statistics, so we can obtain constraints from the true spectral time lags of bunches of high-energy photons rather than from the rough time lag of a single highest-energy photon. Also, GRB 160625B is the only burst to date having a well-definedmore » transition from positive lags to negative lags, providing a unique opportunity to distinguish Lorentz-violating effects from any source-intrinsic time lag in the emission of photons of different energy bands. Our results place comparatively robust two-sided constraints on a variety of isotropic and anisotropic coefficients for Lorentz violation, including the first bounds on Lorentz-violating effects from operators of mass dimension 10 in the photon sector.« less

The effect of control and display lag on unmanned air system internal pilot manual landing performance

NASA Astrophysics Data System (ADS)

Lloyd, Marshall Everett

An important characteristic of UASs is lag because it can become a considerable challenge to successful human-in-the-loop control. As such, UASs are designed and configured to minimize system lag, though this can increase acquisition and operation costs considerably. In an effort to cut costs, an organization may choose to accept greater risk and deploy a UAS with high system lag. Before this risk can be responsibly accepted, it must be quantified. While many studies have examined system lag, very few have been able to quantify the risk that various levels of lag pose to an internally piloted, manually landed UAS. This study attempted to do so by evaluating pilot landing performance in a simulator with 0 ms, 240 ms, and 1000 ms of additional lag. Various measures were used, including a novel coding technique. Results indicated that 1000 ms of lag was unsafe by all measures. They also indicate that 240 ms of lag degrades performance, but participants were able to successfully land the simulated aircraft. This study showed the utility of using several measures to evaluate the effect of lag on landing performance and it helped demonstrate that while 1000 ms poses a high risk, 240 ms of lag may be a much more manageable risk. Future research suggested by this research includes: investigating lag between 240 ms and 1000 ms, introducing different weather phenomena, developing system lag training techniques for operators, and investigating the effect of aides such as predictive displays and autopilot-assisted recovery.

Steam jet ejectors for the process industries. [Glossary included

DOE Office of Scientific and Technical Information (OSTI.GOV)

Power, R.B.

1994-01-01

Steam jet ejectors were for many years the workhorse of the chemical process industries for producing vacuum. With increasing emphasis on stricter pollution control, their use was curtailed. There are still many applications, however, such as those with large capacity requirements, where ejectors are the only equipment that can produce sufficient vacuum. Chapter 1 is a short overview on how to use the text. Chapter 2 discusses what an ejector is and how it works. How ejector stages work is reviewed in Chapter 3. Engineering calculations for ejector stages is thoroughly discussed in Chapter 4. In Chapter 5, contact andmore » surface condensers are reviewed, and calculation procedures are presented. The various types of pressure control are discussed in Chapter 6. Chapter 7 is an excellent review of installation of ejector vacuum systems. The final chapter of Part 2 (Chapters 3--8) thoroughly covers all aspects of operation, testing, troubleshooting and maintenance. Part 3, consisting of two chapters, is devoted to specifying and purchasing steam jet ejectors. Part 4 on other ejector applications and upgrading ejector usage also consists of two chapters. Chapter 11 reviews steam-jet refrigeration, steam-jet and gas-jet compressors, liquid jet eductors, desuperheaters, special design situations, and designing one's own systems. Upgrading of existing ejector procedures and hardware is reviewed in Chapter 12. The 12 appendixes cover: physical properties of common fluids; handy vacuum engineering data and rules of thumb; SI unit conversions; sizing air and steam metering orifices for testing; drill sizes; ejector operating costs and design optimization; forms for ejector calculations, tests, and inspections; instructions for preparing ejector specifications; test kit contents list; ejector manufacturers and suppliers of referenced hardware and information; and failure modes and symptoms.« less

AN INVESTIGATION OF TIME LAG MAPS USING THREE-DIMENSIONAL SIMULATIONS OF HIGHLY STRATIFIED HEATING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winebarger, Amy R.; Lionello, Roberto; Downs, Cooper

2016-11-10

The location and frequency of coronal energy release provide a significant constraint on the coronal heating mechanism. The evolution of the intensity observed in coronal structures found from time lag analysis of Atmospheric Imaging Assembly (AIA) data has been used to argue that heating must occur sporadically. Recently, we have demonstrated that quasi-steady, highly stratified (footpoint) heating can produce results qualitatively consistent with the evolution of observed coronal structures. The goals of this paper are to demonstrate that time lag analysis of 3D simulations of footpoint heating are qualitatively consistent with time lag analysis of observations and to use themore » 3D simulations to further understand whether time lag analysis is a useful tool in defining the evolution of coronal structures. We find the time lag maps generated from simulated data are consistent with the observed time lag maps. We next investigate several example points. In some cases, the calculated time lag reflects the evolution of a unique loop along the line of sight, though there may be additional evolving structures along the line of sight. We confirm that using the multi-peak AIA channels can produce time lags that are difficult to interpret. We suggest using a different high temperature channel, such as an X-ray channel. Finally, we find that multiple evolving structures along the line of sight can produce time lags that do not represent the physical properties of any structure along the line of sight, although the cross-correlation coefficient of the lightcurves is high. Considering the projected geometry of the loops may reduce some of the line-of-sight confusion.« less

Control of jet noise

NASA Technical Reports Server (NTRS)

Schreck, Stefan

1993-01-01

This reports describes experiments conducted at the High-Speed Jet Facility at the University of Southern California on supersonic jets. The goal of the study was to develop methods for controlling the noise emitted from supersonic jets by passive and/or active means. Work by Seiner et al (1991) indicates that eddy Mach wave radiation is the dominant noise source in a heated high speed jet. Eddy Mach radiation is caused by turbulent eddies traveling at supersonic speed in the shear layer of the jet. The convection velocity of the eddies decays with increasing distance from the nozzle exit due to the mixing of the jet stream with the ambient fluid. Once the convection speed reaches subsonic velocities, eddy Mach wave radiation ceases. To control noise, a rapid decay of the convection velocity is desired. This may be accomplished by enhanced mixing in the jet. In this study, small aspect ratio rectangular jet nozzles were tested. A flapping mode was noticed in the jets. By amplifying screech components of the jets and destabilizing the jet columns with a collar device, the flapping mode was excited. The result was a rapid decay of the jet velocity. A reduction in eddy Mach radiation in rectangular supersonic jets may be achieved with this device.

Exotic interactions among C-jets and Pb-jets

NASA Technical Reports Server (NTRS)

1985-01-01

The C-jets and Pb-jets were surveyed on the part of Chacaltaya emulsion chamber No.19 amounting to an exposure of 28.8 sq m yr. It is shown that the adopted events make up an unbiased sample of C-jets for sigma sub E gamma TeV. Mini-Centauro interaction gives the most natural explanation for the eight pinaught-less C-jets with three or more constituent shower core. Out of the eight double-cored pinaught-less events, three are found to have visible invariant masses 1.8 GeV/c. Three Pb-jets-lower are composed of double cores whose respective visible transverse momenta are greater than 0.5 GeV/c, suggesting that they are of Geminion origin or chiron origin. The energies of the parent particles are estimated to be 100 to 200 TeV for all three kinds of events. The implications of this energy estimate and the frequency of observed exotic events are discussed.

Intraseasonal variability in the summer South China Sea: Wind jet, cold filament, and recirculations

NASA Astrophysics Data System (ADS)

Xie, Shang-Ping; Chang, Chueh-Hsin; Xie, Qiang; Wang, Dongxiao

2007-10-01

A recent study shows that the blockage of the southwest monsoon by the mountain range on the east coast of Indochina triggers a chain of ocean-atmospheric response, including a wind jet and cold filament in the South China Sea (SCS). We extend this climatological analysis by using higher temporal resolution (weekly) to study intraseasonal variability in summer. Our analysis shows that the development of the wind jet and cold filament is not a smooth seasonal process but consists of several intraseasonal events each year at about 45-day intervals. In a typical intraseasonal event, the wind jet intensifies to above 12 m/s, followed in a week by the development of a cold filament advected by an offshore jet east of South Vietnam on the boundary of a double gyre circulation in the ocean. The double gyre circulation itself also strengthens in response to the intraseasonal wind event via Rossby wave adjustment, reaching the maximum strength in 2 to 3 weeks. The intraseasonal cold filaments appear to influence the surface wind, reducing the local wind speed because of the increased static stability in the near-surface atmosphere. To first order, the above sequence of events may be viewed as the SCS response to atmospheric intraseasonal wind pulses, which are part of the planetary-scale boreal summer intraseasonal oscillation characterized by the northeastward propagation of atmospheric deep convection. The intraseasonal anomalies of sea surface temperature and precipitation are in phase over the SCS, suggesting an oceanic feedback onto the atmosphere. As wind variations are now being routinely monitored by satellite, the lags of 1-3 weeks in oceanic response offer useful predictability that may be exploited.

Blowout Jets: Hinode X-Ray Jets that Don't Fit the Standard Model

NASA Technical Reports Server (NTRS)

Moore, Ronald L.; Cirtain, Jonathan W.; Sterling, Alphonse C.; Falconer, David A.

2010-01-01

Nearly half of all H-alpha macrospicules in polar coronal holes appear to be miniature filament eruptions. This suggests that there is a large class of X-ray jets in which the jet-base magnetic arcade undergoes a blowout eruption as in a CME, instead of remaining static as in most solar X-ray jets, the standard jets that fit the model advocated by Shibata. Along with a cartoon depicting the standard model, we present a cartoon depicting the signatures expected of blowout jets in coronal X-ray images. From Hinode/XRT movies and STEREO/EUVI snapshots in polar coronal holes, we present examples of (1) X-ray jets that fit the standard model, and (2) X-ray jets that do not fit the standard model but do have features appropriate for blowout jets. These features are (1) a flare arcade inside the jet-base arcade in addition to the small flare arcade (bright point) outside that standard jets have, (2) a filament of cool (T is approximately 80,000K) plasma that erupts from the core of the jetbase arcade, and (3) an extra jet strand that should not be made by the reconnection for standard jets but could be made by reconnection between the ambient unipolar open field and the opposite-polarity leg of the filament-carrying flux-rope core field of the erupting jet-base arcade. We therefore infer that these non-standard jets are blowout jets, jets made by miniature versions of the sheared-core-arcade eruptions that make CMEs

Velocity field near the jet orifice of a round jet in a crossflow

NASA Technical Reports Server (NTRS)

Fearn, R. L.; Benson, J. P.

1979-01-01

Experimentally determined velocities at selected locations near the jet orifice are presented and analyzed for a round jet in crossflow. Jet-to-crossflow velocity ratios of four and eight were studied experimentally for a round subsonic jet of air exhausting perpendicularly through a flat plate into a subsonic crosswind of the same temperature. Velocity measurements were made in cross sections to the jet plume located from one to four jet diameters from the orifice. Jet centerline and vortex properties are presented and utilized to extend the results of a previous study into the region close to the jet orifice.

46 CFR 98.25-30 - Lagging.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

46 CFR 98.25-30 - Lagging.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

46 CFR 98.25-30 - Lagging.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

46 CFR 98.25-30 - Lagging.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

46 CFR 98.25-30 - Lagging.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Lagging. 98.25-30 Section 98.25-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk § 98.25-30...

Modeling eye gaze patterns in clinician-patient interaction with lag sequential analysis.

PubMed

Montague, Enid; Xu, Jie; Chen, Ping-Yu; Asan, Onur; Barrett, Bruce P; Chewning, Betty

2011-10-01

The aim of this study was to examine whether lag sequential analysis could be used to describe eye gaze orientation between clinicians and patients in the medical encounter. This topic is particularly important as new technologies are implemented into multiuser health care settings in which trust is critical and nonverbal cues are integral to achieving trust. This analysis method could lead to design guidelines for technologies and more effective assessments of interventions. Nonverbal communication patterns are important aspects of clinician-patient interactions and may affect patient outcomes. The eye gaze behaviors of clinicians and patients in 110 videotaped medical encounters were analyzed using the lag sequential method to identify significant behavior sequences. Lag sequential analysis included both event-based lag and time-based lag. Results from event-based lag analysis showed that the patient's gaze followed that of the clinician, whereas the clinician's gaze did not follow the patient's. Time-based sequential analysis showed that responses from the patient usually occurred within 2 s after the initial behavior of the clinician. Our data suggest that the clinician's gaze significantly affects the medical encounter but that the converse is not true. Findings from this research have implications for the design of clinical work systems and modeling interactions. Similar research methods could be used to identify different behavior patterns in clinical settings (physical layout, technology, etc.) to facilitate and evaluate clinical work system designs.

Modeling Eye Gaze Patterns in Clinician-Patient Interaction with Lag Sequential Analysis

PubMed Central

Montague, E; Xu, J; Asan, O; Chen, P; Chewning, B; Barrett, B

2011-01-01

Objective The aim of this study was to examine whether lag-sequential analysis could be used to describe eye gaze orientation between clinicians and patients in the medical encounter. This topic is particularly important as new technologies are implemented into multi-user health care settings where trust is critical and nonverbal cues are integral to achieving trust. This analysis method could lead to design guidelines for technologies and more effective assessments of interventions. Background Nonverbal communication patterns are important aspects of clinician-patient interactions and may impact patient outcomes. Method Eye gaze behaviors of clinicians and patients in 110-videotaped medical encounters were analyzed using the lag-sequential method to identify significant behavior sequences. Lag-sequential analysis included both event-based lag and time-based lag. Results Results from event-based lag analysis showed that the patients’ gaze followed that of clinicians, while clinicians did not follow patients. Time-based sequential analysis showed that responses from the patient usually occurred within two seconds after the initial behavior of the clinician. Conclusion Our data suggest that the clinician’s gaze significantly affects the medical encounter but not the converse. Application Findings from this research have implications for the design of clinical work systems and modeling interactions. Similar research methods could be used to identify different behavior patterns in clinical settings (physical layout, technology, etc.) to facilitate and evaluate clinical work system designs. PMID:22046723

A new method for determining the optimal lagged ensemble

PubMed Central

DelSole, T.; Tippett, M. K.; Pegion, K.

2017-01-01

Abstract We propose a general methodology for determining the lagged ensemble that minimizes the mean square forecast error. The MSE of a lagged ensemble is shown to depend only on a quantity called the cross‐lead error covariance matrix, which can be estimated from a short hindcast data set and parameterized in terms of analytic functions of time. The resulting parameterization allows the skill of forecasts to be evaluated for an arbitrary ensemble size and initialization frequency. Remarkably, the parameterization also can estimate the MSE of a burst ensemble simply by taking the limit of an infinitely small interval between initialization times. This methodology is applied to forecasts of the Madden Julian Oscillation (MJO) from version 2 of the Climate Forecast System version 2 (CFSv2). For leads greater than a week, little improvement is found in the MJO forecast skill when ensembles larger than 5 days are used or initializations greater than 4 times per day. We find that if the initialization frequency is too infrequent, important structures of the lagged error covariance matrix are lost. Lastly, we demonstrate that the forecast error at leads ≥10 days can be reduced by optimally weighting the lagged ensemble members. The weights are shown to depend only on the cross‐lead error covariance matrix. While the methodology developed here is applied to CFSv2, the technique can be easily adapted to other forecast systems. PMID:28580050

LAG-3 Represents a Marker of CD4+ T Cells with Regulatory Activity in Patients with Bone Fracture.

PubMed

Wang, Jun; Ti, Yunfan; Wang, Yicun; Guo, Guodong; Jiang, Hui; Chang, Menghan; Qian, Hongbo; Zhao, Jianning; Sun, Guojing

2018-04-19

The lymphocyte activation gene 3 (LAG-3) is a CD4 homolog with binding affinity to MHC class II molecules. It is thought that LAG-3 exerts a bimodal function, such that co-ligation of LAG-3 and CD3 could deliver an inhibitory signal in conventional T cells, whereas, on regulatory T cells, LAG-3 expression could promote their inhibitory function. In this study, we investigated the role of LAG-3 expression on CD4 + T cells in patients with long bone fracture. We found that LAG-3 + cells represented approximately 13% of peripheral blood CD4 + T cells on average. Compared to LAG-3 - CD4 + T cells, LAG-3 + CD4 + T cells presented significantly higher Foxp3 and CTLA-4 expression. Directly ex vivo or with TCR stimulation, LAG-3 + CD4 + T cells expressed significantly higher levels of IL-10 and TGF-β than LAG-3 - CD4 + T cells. Interestingly, blocking the LAG-3-MHC class II interaction actually increased the IL-10 expression by LAG-3 + CD4 + T cells. The frequency of LAG-3 + CD4 + T cell was positively correlated with restoration of healthy bone function in long bone fracture patients. These results together suggested that LAG-3 is a marker of CD4 + T cells with regulatory function; at the same time, LAG-3 might have limited the full suppressive potential of Treg cells.

Reciprocal associations between depressive symptoms and disordered eating among adolescent girls and boys: a multiwave, prospective study.

PubMed

Ferreiro, Fátima; Wichstrøm, Lars; Seoane, Gloria; Senra, Carmen

2014-01-01

Symptoms of depression and eating disorders increase during adolescence, particularly among girls, and they tend to co-occur. Despite this evidence, there is meager research on whether depression increases the risk of future eating pathology, or vice versa, and we do not know whether these processes are different for adolescent girls and boys. Accordingly, this study explored the prospective reciprocal associations between depressive symptoms and disordered eating at different time points from preadolescence to mid-adolescence and tested the moderator effect of gender on these associations. A community-based sample of Spanish youth (N = 942, 49 % female) was assessed at ages of approximately 10-11 (T1), 12-13 (T2), 14-15 (T3), and 16-17 (T4) years. The bidirectional relationships between depressive symptoms and disordered eating were estimated in an autoregressive cross-lagged model with latent variables. A unidirectional, age-specific association between depressive symptoms at T1 and disordered eating at T2 was found. No other significant cross-lagged effect emerged, but the stability of the constructs was considerable. Gender did not moderate any of the links examined. Regardless of gender, the transition from childhood to adolescence appears to be a key period when depressive symptoms foster the development of disordered eating. These findings suggest that early prevention and treatment of depression targeting both girls and boys may result in lower levels of depressive symptoms and disordered eating in adolescence.

Co-rumination buffers the link between social anxiety and depressive symptoms in early adolescence.

PubMed

Van Zalk, Nejra; Tillfors, Maria

2017-01-01

We examined whether co-rumination with online friends buffered the link between social anxiety and depressive symptoms over time in a community sample. In a sample of 526 participants (358 girls; M age  = 14.05) followed at three time points, we conducted a latent cross-lagged model with social anxiety, depressive symptoms, and co-rumination, controlling for friendship stability and friendship quality, and adding a latent interaction between social anxiety and co-rumination predicting depressive symptoms. Social anxiety predicted depressive symptoms, but no direct links between social anxiety and co-rumination emerged. Instead, co-rumination buffered the link between social anxiety and depressive symptoms for adolescents with higher but not lower levels of social anxiety. These findings indicate that co-rumination exerted a positive influence on interpersonal relationships by diminishing the influence from social anxiety on depressive symptoms over time.

Increased Variability in Tacting under a Lag 3 Schedule of Reinforcement

ERIC Educational Resources Information Center

Heldt, Juliane; Schlinger, Henry D., Jr.

2012-01-01

Research has shown that variability may be an operant dimension of behavior. One method of reinforcing response variability is to use a lag schedule of reinforcement (Page & Neuringer, 1985). Several studies have shown that a Lag 1 schedule is effective in increasing variable responding with human participants (e.g., Esch, Esch, & Love, 2009; Lee,…

The Lag-Luminosity Relation in the GRB Source-Frame: An Investigation with Swift BAT Bursts

NASA Technical Reports Server (NTRS)

Ukwatta, T. N.; Dhuga, K. S.; Stamatikos, M.; Dermer, C. D.; Sakamoto, T.; Sonbas, E.; Parke, W. C.; Maximon, L. C.; Linnemann, J. T.; Bhat, P. N.;

Yeast multistress resistance and lag-phase characterisation during wine fermentation.

PubMed

Ferreira, David; Galeote, Virginie; Sanchez, Isabelle; Legras, Jean-Luc; Ortiz-Julien, Anne; Dequin, Sylvie

2017-09-01

Saccharomyces cerevisiae has been used to perform wine fermentation for several millennia due to its endurance and unmatched qualities. Nevertheless, at the moment of inoculation, wine yeasts must cope with specific stress factors that still challenge wine makers by slowing down or compromising the fermentation process. To better assess the role of genetic and environmental factors that govern multistress resistance during the wine fermentation lag phase, we used a factorial plan to characterise the individual and combined impact of relevant stress factors on eight S. cerevisiae and two non-S. cerevisiae wine yeast strains that are currently commercialised. The S. cerevisiae strains are very genetically diverse, belonging to the wine and flor groups, and frequently contain a previously described XVIVIII translocation that confers increased resistance to sulphites. We found that low temperature and osmotic stress substantially affected all strains, promoting considerably extended lag phases. SO2 addition had a partially temperature-dependent effect, whereas low phytosterol and thiamine concentrations impacted the lag phase in a strain-dependent manner. No major synergic effects of multistress were detected. The diversity of lag-phase durations and stress responses observed among wine strains offer new insights to better control this critical step of fermentation. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Lag and seasonality considerations in evaluating AVHRR NDVI response to precipitation

USGS Publications Warehouse

Ji, Lei; Peters, Albert J.

2005-01-01

Assessment of the relationship between the normalized difference vegetation index (NDVI) and precipitation is important in understanding vegetation and climate interaction at a large scale. NDVI response to precipitation, however, is difficult to quantify due to the lag and seasonality effects, which will vary due to vegetation cover type, soils and climate. A time series analysis was performed on biweekly NDVI and precipitation around weather stations in the northern and central U.S. Great Plains. Regression models that incorporate lag and seasonality effects were used to quantify the relationship between NDVI and lagged precipitation in grasslands and croplands. It was found that the time lag was shorter in the early growing season, but longer in the mid- to late-growing season for most locations. The regression models with seasonal adjustment indicate that the relationship between NDVI and precipitation over the entire growing season was strong, with R2 values of 0.69 and 0.72 for grasslands and croplands, respectively. We conclude that vegetation greenness can be predicted using current and antecedent precipitation, if seasonal effects are taken into account.

Hydrophilic excipients modulate the time lag of time-controlled disintegrating press-coated tablets.

PubMed

Lin, Shan-Yang; Li, Mei-Jane; Lin, Kung-Hsu

2004-08-16

An oral press-coated tablet was developed by means of direct compression to achieve the time-controlled disintegrating or rupturing function with a distinct predetermined lag time. This press-coated tablet containing sodium diclofenac in the inner core was formulated with an outer shell by different weight ratios of hydrophobic polymer of micronized ethylcellulose (EC) powder and hydrophilic excipients such as spray-dried lactose (SDL) or hydroxypropyl methylcellulose (HPMC). The effect of the formulation of an outer shell comprising both hydrophobic polymer and hydrophilic excipients on the time lag of drug release was investigated. The release profile of the press-coated tablet exhibited a time period without drug release (time lag) followed by a rapid and complete release phase, in which the outer shell ruptured or broke into 2 halves. The lag phase was markedly dependent on the weight ratios of EC/SDL or EC/HPMC in the outer shell. Different time lags of the press-coated tablets from 1.0 to 16.3 hours could be modulated by changing the type and amount of the excipients. A semilogarithmic plot of the time lag of the tablet against the weight ratios of EC/SDL or EC/HPMC in the outer shell demonstrated a good linear relationship, with r = 0.976 and r = 0.982, respectively. The predetermined time lag prior to the drug release from a press-coated tablet prepared by using a micronized EC as a retarding coating shell can be adequately scheduled with the addition of hydrophilic excipients according to the time or site requirements.

Assessing protein conformational sampling methods based on bivariate lag-distributions of backbone angles

PubMed Central

Maadooliat, Mehdi; Huang, Jianhua Z.

2013-01-01

Despite considerable progress in the past decades, protein structure prediction remains one of the major unsolved problems in computational biology. Angular-sampling-based methods have been extensively studied recently due to their ability to capture the continuous conformational space of protein structures. The literature has focused on using a variety of parametric models of the sequential dependencies between angle pairs along the protein chains. In this article, we present a thorough review of angular-sampling-based methods by assessing three main questions: What is the best distribution type to model the protein angles? What is a reasonable number of components in a mixture model that should be considered to accurately parameterize the joint distribution of the angles? and What is the order of the local sequence–structure dependency that should be considered by a prediction method? We assess the model fits for different methods using bivariate lag-distributions of the dihedral/planar angles. Moreover, the main information across the lags can be extracted using a technique called Lag singular value decomposition (LagSVD), which considers the joint distribution of the dihedral/planar angles over different lags using a nonparametric approach and monitors the behavior of the lag-distribution of the angles using singular value decomposition. As a result, we developed graphical tools and numerical measurements to compare and evaluate the performance of different model fits. Furthermore, we developed a web-tool (http://www.stat.tamu.edu/∼madoliat/LagSVD) that can be used to produce informative animations. PMID:22926831

The free jet as a simulator of forward velocity effects on jet noise

NASA Technical Reports Server (NTRS)

Ahuja, K. K.; Tester, B. J.; Tanna, H. K.

1978-01-01

A thorough theoretical and experimental study of the effects of the free-jet shear layer on the transmission of sound from a model jet placed within the free jet to the far-field receiver located outside the free-jet flow was conducted. The validity and accuracy of the free-jet flight simulation technique for forward velocity effects on jet noise was evaluated. Transformation charts and a systematic computational procedure for converting measurements from a free-jet simulation to the corresponding results from a wind-tunnel simulation, and, finally, to the flight case were provided. The effects of simulated forward flight on jet mixing noise, internal noise and shock-associated noise from model-scale unheated and heated jets were established experimentally in a free-jet facility. It was illustrated that the existing anomalies between full-scale flight data and model-scale flight simulation data projected to the flight case, could well be due to the contamination of flight data by engine internal noise.

Clarifying the Link between Parental Psychological Control and Adolescents' Depressive Symptoms: Reciprocal versus Unidirectional Models

ERIC Educational Resources Information Center

Soenens, Bart; Luyckx, Koen; Vansteenkiste, Maarten; Duriez, Bart; Goossens, Luc

2008-01-01

Research has demonstrated consistent positive associations between perceived parental psychological control and adolescents' depressive symptoms, but the direction of influence remains unclear. Using a cross-lagged longitudinal design in two samples of late (Study 1, N = 396) and middle (Study 2, N = 724) adolescents, this study compared three…

NASA Jet Noise Research

NASA Technical Reports Server (NTRS)

Henderson, Brenda

2016-01-01

The presentation highlights NASA's jet noise research for 2016. Jet-noise modeling efforts, jet-surface interactions results, acoustic characteristics of multi-stream jets, and N+2 Supersonic Aircraft system studies are presented.

Measuring attention using flash-lag effect.

PubMed

Shioiri, Satoshi; Yamamoto, Ken; Oshida, Hiroki; Matsubara, Kazuya; Yaguchi, Hirohisa

2010-08-13

We investigated the effect of attention on the flash-lag effect (FLE) in order to determine whether the FLE can be used to estimate the effect of visual attention. The FLE is the effect that a flash aligned with a moving object is perceived to lag the moving object, and several studies have shown that attention reduces its magnitude. We measured the FLE as a function of the number or speed of moving objects. The results showed that the effect of cueing, which we attributed the effect of attention, on the FLE increased monotonically with the number or the speed of the objects. This suggests that the amount of attention can be estimated by measuring the FLE, assuming that more amount of attention is required for a larger number or faster speed of objects to attend. On the basis of this presumption, we attempted to measure the spatial spread of visual attention by FLE measurements. The estimated spatial spreads were similar to those estimated by other experimental methods.

Cosmic jets

NASA Technical Reports Server (NTRS)

Rees, M. J.

1986-01-01

The evidence that active galactic nuclei produce collimated plasma jets is summarised. The strongest radio galaxies are probably energised by relativistic plasma jets generated by spinning black holes interacting with magnetic fields attached to infalling matter. Such objects can produce e(+)-e(-) plasma, and may be relevant to the acceleration of the highest-energy cosmic ray primaries. Small-scale counterparts of the jet phenomenon within our own galaxy are briefly reviewed.

Interaction of argon and helium plasma jets and jets arrays with account for gravity

NASA Astrophysics Data System (ADS)

Babaeva, Natalia Yu.; Naidis, George V.; Panov, Vladislav A.; Wang, Ruixue; Zhao, Yong; Shao, Tao

2018-06-01

In this paper, we discuss results from an experimental and computational study of the properties of a single jet and two-tube jet arrays operating in argon and helium. The jets are positioned horizontally. It was shown in experiments that the helium plasma plume bends upward and the plumes in the two-tubes jet array tend to divert due to the jet-jet interaction. To investigate these potential interactions, a computational study was performed of one- and two-tube argon and helium jet arrays having variable spacing. The effects of buoyancy forces on the jet-to-jet interaction of the plasma plumes are also investigated. Velocities of ionization waves inside and outside the tubes are estimated and compared for the argon and helium ionization waves. We show that in helium jet-jet interactions primarily depend on the spacing between the tubes and on the buoyancy forces. The helium plumes tend to merge into one single stream before dissipating, while the argon plasma plumes are less sensitive to the spacing of the jet tubes.

Jets in Planetary Atmospheres

NASA Astrophysics Data System (ADS)

Dowling, Tim

2018-05-01

Jet streams, "jets" for short, are remarkably coherent streams of air found in every major atmosphere. They have a profound effect on a planet's global circulation, and have been an enigma since the belts and zones of Jupiter were discovered in the 1600s. The study of jets, including what processes affect their size, strength, direction, shear stability, and predictability, are active areas of research in geophysical fluid dynamics. Jet research is multidisciplinary and global, involving collaborations between observers, experimentalists, numerical modelers, and applied mathematicians. Jets in atmospheres have strong analogies with shear instability in nonneutral plasmas, and these connections are highlighted throughout the article. The article begins with a description of four major challenges that jet researchers face: nonlinearity, non-intuitive wave physics, non-constant-coefficients, and copious nondimensional numbers. Then, two general fluid-dynamical tenets, the practice of rendering expressions dimensionally homogeneous (nondimensional), and the universal properties of shocks are applied to the open question of what controls the on-off switch of shear instability. The discussion progresses to how the physics of jets varies in equatorial, midlatitude, and polar regions, and how jets are observed to behave in each of these settings. The all-in-one conservation law of potential vorticity (PV), which combines the conservation laws of mass, momentum, and thermal energy into a single expression, is the common language of jet research. Earth and Uranus have weak retrograde equatorial jets, but most planets exhibit super-rotating equatorial jets, which require eddies to transport momentum up gradient in a non-intuitive manner. Jupiter and Saturn exhibit multiple alternating jets in their midlatitudes. The theory for why jets are invariably zonal (east-west orientated) is reviewed, and the particular challenges that Jupiter's sharp westward jets present to existing

Jet noise suppression

NASA Astrophysics Data System (ADS)

Gliebe, P. R.; Brausch, J. F.; Majjigi, R. K.; Lee, R.

1991-08-01

The objectives of this chapter are to review and summarize the jet noise suppression technology, to provide a physical and theoretical model to explain the measured jet noise suppression characteristics of different concepts, and to provide a set of guidelines for evolving jet noise suppression designs. The underlying principle for all jet noise suppression devices is to enhance rapid mixing (i.e., diffusion) of the jet plume by geometric and aerothermodynamic means. In the case of supersonic jets, the shock-cell broadband noise reduction is effectively accomplished by the elimination or mitigation of the shock-cell structure. So far, the diffusion concepts have predominantly concentrated on jet momentum and energy (kinetic and thermal) diffusion, in that order, and have yielded better noise reduction than the simple conical nozzles. A critical technology issue that needs resolution is the effect of flight on the noise suppression potential of mechanical suppressor nozzles. A more thorough investigation of this mechanism is necessary for the successful development and design of an acceptable noise suppression device for future high-speed civil transports.

Control of jet noise

NASA Technical Reports Server (NTRS)

Schreck, Stefan

1992-01-01

To investigate the possibility of active control of jet noise, knowledge of the noise generation mechanisms in natural jets is essential. Once these mechanisms are determined, active control can be used to manipulate the noise production processes. We investigated the evolution of the flow fields and the acoustic fields of rectangular and circular jets. A predominant flapping mode was found in the supersonic rectangular jets. We hope to increase the spreading of supersonic jets by active control of the flapping mode found in rectangular supersonic jets.

The Lag-Luminosity Relation in the GRB Source Frame: An Investigation with Swift BAT Bursts

NASA Technical Reports Server (NTRS)

Ukwatta, T. N.; Dhuga, K. S.; Stamatikos, M.; Dermer, C. D.; Sakamoto, T.; Sonbas, E.; Parke, W. C.; Maximon, L. C.; Linnemann, J. T.; Bhat, P. N.;

A generalized expression for lag-time in the gas-phase permeation of hollow tubes

NASA Technical Reports Server (NTRS)

Shah, K. K.; Nelson, H. G.; Johnson, D. L.; Hamaker, F. M.

1975-01-01

A generalized expression for the nonsteady-state parameter, lag-time, has been obtained from Fick's second law for gas-phase transport through hollow, cylindrical membranes. This generalized expression is simplified for three limiting cases of practical interest: (1) diffusion controlled transport, (2) phase boundary reaction control at the inlet surface, and (3) phase boundary reaction control at the outlet surface. In all three cases the lag-time expressions were found to be inversely proportional only to the diffusion coefficient and functionally dependent on the membrane radii. Finally, the lag-time expressions were applied to experimentally obtained lag-time data for alpha-phase titanium and alpha-phase iron.

Water Jetting

NASA Technical Reports Server (NTRS)

1985-01-01

Hi-Tech Inc., a company which manufactures water jetting equipment, needed a high pressure rotating swivel, but found that available hardware for the system was unsatisfactory. They were assisted by Marshall, which had developed water jetting technology to clean the Space Shuttles. The result was a completely automatic water jetting system which cuts rock and granite and removes concrete. Labor costs have been reduced; dust is suppressed and production has been increased.

Aeroacoustic Experiments with Twin Jets

NASA Technical Reports Server (NTRS)

Bozak, Richard F.; Henderson, Brenda S.

2012-01-01

While the noise produced by a single jet is azimuthally symmetric, multiple jets produce azimuthally varying far-field noise. The ability of one jet to shield another reduces the noise radiated in the plane of the jets, while often increasing the noise radiated out of the plane containing the jets. The present study investigates the shielding potential of twin jet configurations over subsonic and over-expanded supersonic jet conditions with simulated forward flight. The experiments were conducted with 2 in. throat diameter nozzles at four jet spacings from 2.6d to 5.5d in center-to-center distance, where d is the nozzle throat diameter. The current study found a maximum of 3 dB reduction in overall sound pressure level relative to two incoherent jets in the peak jet noise direction in the plane containing the jets. However, an increase of 3 dB was found perpendicular to the plane containing the jets. In the sideline direction, shielding is observed for all jet spacings in this study.

Electronic trigger for capacitive touchscreen and extension of ISO 15781 standard time lag measurements to smartphones

NASA Astrophysics Data System (ADS)

Bucher, François-Xavier; Cao, Frédéric; Viard, Clément; Guichard, Frédéric

2014-03-01

We present in this paper a novel capacitive device that stimulates the touchscreen interface of a smartphone (or of any imaging device equipped with a capacitive touchscreen) and synchronizes triggering with the DxO LED Universal Timer to measure shooting time lag and shutter lag according to ISO 15781:2013. The device and protocol extend the time lag measurement beyond the standard by including negative shutter lag, a phenomenon that is more and more commonly found in smartphones. The device is computer-controlled, and this feature, combined with measurement algorithms, makes it possible to automatize a large series of captures so as to provide more refined statistical analyses when, for example, the shutter lag of "zero shutter lag" devices is limited by the frame time as our measurements confirm.

Studies of jet mass in dijet and W/Z + jet events

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.

Invariant mass spectra for jets reconstructed using the anti-kt and Cambridge-Aachen algorithms are studied for different jet "grooming" techniques in data corresponding to an integrated luminosity of 5 inverse femtobarns, recorded with the CMS detector in proton-proton collisions at the LHC at a center-of-mass energy of 7 TeV. Leading-order QCD predictions for inclusive dijet and W/Z+jet production combined with parton-shower Monte Carlo models are found to agree overall with the data, and the agreement improves with the implementation of jet grooming methods used to distinguish merged jets of large transverse momentum from softer QCD gluon radiation.

Solar Active Region Coronal Jets. II. Triggering and Evolution of Violent Jets

NASA Astrophysics Data System (ADS)

Sterling, Alphonse C.; Moore, Ronald L.; Falconer, David A.; Panesar, Navdeep K.; Martinez, Francisco

2017-07-01

We study a series of X-ray-bright, rapidly evolving active region coronal jets outside the leading sunspot of AR 12259, using Hinode/X-ray telescope, Solar Dynamics Observatory (SDO)/Atmospheric Imaging Assembly (AIA) and Helioseismic and Magnetic Imager (HMI), and Interface Region Imaging Spectrograph (IRIS) data. The detailed evolution of such rapidly evolving “violent” jets remained a mystery after our previous investigation of active region jets. The jets we investigate here erupt from three localized subregions, each containing a rapidly evolving (positive) minority-polarity magnetic-flux patch bathed in a (majority) negative-polarity magnetic-flux background. At least several of the jets begin with eruptions of what appear to be thin (thickness ≲ 2\\prime\\prime ) miniature-filament (minifilament) “strands” from a magnetic neutral line where magnetic flux cancelation is ongoing, consistent with the magnetic configuration presented for coronal-hole jets in Sterling et al. (2016). Some jets strands are difficult/impossible to detect, perhaps due to, e.g., their thinness, obscuration by surrounding bright or dark features, or the absence of erupting cool-material minifilaments in those jets. Tracing in detail the flux evolution in one of the subregions, we find bursts of strong jetting occurring only during times of strong flux cancelation. Averaged over seven jetting episodes, the cancelation rate was ˜ 1.5× {10}19 Mx hr-1. An average flux of ˜ 5× {10}18 Mx canceled prior to each episode, arguably building up ˜1028-1029 erg of free magnetic energy per jet. From these and previous observations, we infer that flux cancelation is the fundamental process responsible for the pre-eruption build up and triggering of at least many jets in active regions, quiet regions, and coronal holes.

Early adolescent symptoms of social phobia prospectively predict alcohol use.

PubMed

Dahne, Jennifer; Banducci, Anne N; Kurdziel, Gretchen; MacPherson, Laura

2014-11-01

The current study examined whether social phobia (SP) symptoms in early adolescence prospectively predicted alcohol use through middle adolescence in a community sample of youth. Data from an ongoing longitudinal study (N = 277) of mechanisms of HIV-related risk behaviors in youth were used to assess the extent to which SP symptoms in early adolescence (mean [SD] age = 11.00 years [0.81]) would predict alcohol use across five annual assessment waves. Adolescents completed measures of SP symptoms, depressive symptoms, and alcohol use at each wave. Higher SP symptoms at baseline predicted higher average odds of alcohol consumption during subsequent waves but did not significantly predict an increase in the odds of alcohol use as a function of time. Within a lagged model, SP symptoms measured at a prior assessment point (1 year earlier) predicted greater odds of drinking alcohol at the following assessment point. Importantly, alcohol use did not significantly predict SP symptoms over time. These results suggest that early SP symptoms are an important risk factor for increased odds of subsequent alcohol use. The present findings highlight that elevated SP symptoms place adolescents at risk for early alcohol use. Early interventions targeting SP symptoms may be crucial for the prevention of problematic alcohol use in early to mid-adolescence. Implications for prevention and treatment approaches are discussed.

Twin Jet Effects on Noise of Round and Rectangular Jets: Experiment and Model

NASA Technical Reports Server (NTRS)

Bozak, Rick

2014-01-01

Many subsonic and supersonic aircraft concepts proposed by NASA's Fundamental Aeronautics Program have asymmetric, integrated propulsion systems. The asymmetries in the exhaust of these propulsion systems create an asymmetric acoustic field. The asymmetries investigated in the current study are from twin jets and rectangular nozzles. Each effect produces its own variation of the acoustic field. An empirical model was developed to predict the acoustic field variation from round twin jets with twin jet spacing from 2.6 to 5.6, where s is the center-to-center spacing over the jet diameter. The model includes parameters to account for the effects of twin jet spacing, jet static temperature ratio, flight Mach number, frequency, and observer angle (both polar and azimuthal angles). The model was then applied to twin 2:1 and 8:1 aspect ratio nozzles to determine the impact of jet aspect ratio. For the round and rectangular jets, the use of the model reduces the average magnitude of the error over all frequencies, observation angles, and jet spacings by approximately 0.5dB when compared against the assumption of adding two jets incoherently.

Multiple jet study

NASA Technical Reports Server (NTRS)

Walker, R. E.; Kors, D. L.

1973-01-01

Test data is presented which allows determination of jet penetration and mixing of multiple cold air jets into a ducted subsonic heated mainstream flow. Jet-to-mainstream momentum flux ratios ranged from 6 to 60. Temperature profile data is presented at various duct locations up to 24 orifice diameters downstream of the plane of jet injection. Except for two configurations, all geometries investigated had a single row of constant diameter orifices located transverse to the main flow direction. Orifice size and spacing between orifices were varied. Both of these were found to have a significant effect on jet penetration and mixing. The best mixing of the hot and cold streams was achieved with duct height.

Inflammatory Bowel Disease in South Limburg (the Netherlands) 1991-2002: Incidence, diagnostic delay, and seasonal variations in onset of symptoms.

PubMed

Romberg-Camps, Mariëlle J L; Hesselink-van de Kruijs, Martine A M; Schouten, Leo J; Dagnelie, Pieter C; Limonard, Charles B; Kester, Arnold D M; Bos, Laurens P; Goedhard, Jelle; Hameeteman, Wim H A; Wolters, Frank L; Russel, Maurice G V M; Stockbrügger, Reinhold W

2009-06-01

Increasing incidence in Inflammatory Bowel Disease (IBD) has been suggested. Recent data on population based incidence rates within Europe are however scarce. Primary aim was to investigate prospectively the incidence of IBD within a well-defined geographical and administrative area of the Netherlands, the South Limburg IBD registry. Secondary aims were to study the duration of symptoms before diagnosis (lag time) and seasonal influences on the incidence of IBD. The incidence was examined using standardized registration of all newly diagnosed IBD patients, between 1-1-1991 and 1-1-2003. Medical records were reviewed to verify the diagnosis. At inclusion, diagnostic lag time was registered in months. Age standardized incidence rates per 100,000 person-years (p-y) were: Crohn's Disease, male 4.84, female 7.58; Ulcerative Colitis, male 8.51, female 6.92; and Indeterminate Colitis, male 1.05, female 0.93. Incidence rates did not significantly changes over time in either Crohn's Disease, Ulcerative Colitis or Indeterminate Colitis. Lag time was 5 (0-360) months in Crohn's Disease, 3.0 (0-480) months in Ulcerative Colitis and 3.0 (0-180) months in Indeterminate Colitis. Lag time was not significantly different between the periods 1991-1993 and 2000-2002, and no statistical differences in the onset of symptoms per calendar month or season were found. Our results, from the South Limburg region (the Netherlands), show no significant change in incidence rates of IBD. The incidence found is relatively high compared to other European countries. Lag time did not change during the study period, and seasonal influence of incidence rates could not be confirmed.

Jet simulations and gamma-ray burst afterglow jet breaks

NASA Astrophysics Data System (ADS)

van Eerten, H. J.; Meliani, Z.; Wijers, R. A. M. J.; Keppens, R.

2011-01-01

The conventional derivation of the gamma-ray burst afterglow jet break time uses only the blast wave fluid Lorentz factor and therefore leads to an achromatic break. We show that in general gamma-ray burst afterglow jet breaks are chromatic across the self-absorption break. Depending on circumstances, the radio jet break may be postponed significantly. Using high-accuracy adaptive mesh fluid simulations in one dimension, coupled to a detailed synchrotron radiation code, we demonstrate that this is true even for the standard fireball model and hard-edged jets. We confirm these effects with a simulation in two dimensions. The frequency dependence of the jet break is a result of the angle dependence of the emission, the changing optical depth in the self-absorbed regime and the shape of the synchrotron spectrum in general. In the optically thin case the conventional analysis systematically overestimates the jet break time, leading to inferred opening angles that are underestimated by a factor of ˜1.3 and explosion energies that are underestimated by a factor of ˜1.7, for explosions in a homogeneous environment. The methods presented in this paper can be applied to adaptive mesh simulations of arbitrary relativistic fluid flows. All analysis presented here makes the usual assumption of an on-axis observer.

Mixing augmentation of transverse hydrogen jet by injection of micro air jets in supersonic crossflow

NASA Astrophysics Data System (ADS)

Anazadehsayed, A.; Barzegar Gerdroodbary, M.; Amini, Y.; Moradi, R.

2017-08-01

In this study, the influences of the micro air jet on the mixing of the sonic transverse hydrogen through micro-jets subjected to a supersonic crossflow are investigated. A three-dimensional numerical study has been performed to reveal the affects of micro air jet on mixing of the hydrogen jet in a Mach 4.0 crossflow with a global equivalence ratio of 0.5. Parametric studies were conducted on the various air jet conditions by using the Reynolds-averaged Navier-Stokes equations with Menter's Shear Stress Transport (SST) turbulence model. Complex jet interactions were found in the downstream region with a variety of flow features depending upon the angle of micro air jet. These flow features were found to have subtle effects on the mixing of hydrogen jets. Results indicate a different flow structure as air jet is presented in the downstream of the fuel jet. According to the results, without air, mixing occurs at a low rate. When the air jet is presented in the downstream of fuel jet, significant increase (up to 300%) occurs in the mixing performance of the hydrogen jet at downstream. In multi fuel jets, the mixing performance of the fuel jet is increased more than 200% when the micro air jet is injected. Consequently, an enhanced mixing zone occurs downstream of the injection slots which leads to flame-holding.

On the thermal runaway of combustible fluids in lagging material

NASA Astrophysics Data System (ADS)

McIntosh, A. C.; Griffiths, J. F.

1995-01-01

This paper presents the mathematical foundations for a simple theory for investigating the phenomenon of ignition of flammable fluids in lagging material that are used for insulation of hot pipework, for transport of heat transfer fluids, or other similar situations. Experiments with porous material impregnated with a flammable fluid have simulated the self-heating known to occur when combustible liquids leak from a hot pipe into lagging surrounding the pipe or are split from another source on to the lagging. A theory to explain these findings is presented which shows that there is a watershed temperature beyond which substantial self-heating will take place. Although the theory does not take account of diffusion, it simulates the main physics of the phenomenon-that is, combustible fluid, which normally in the open air would evaporate and not be a hazard, can, within a porous medium, remain dispersed within the porous structure long enough for the exothermic oxidation to develop into ignition.

Submerged jet mixing in nuclear waste tanks: a correlation for jet velocity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daas, M.; Srivastava, R.; Roelant, D.

2007-07-01

Experimental studies were carried out in jet-stirred slurry tanks to correlate the influence of nozzle diameter, initial jet flow velocity, submerged depth of jet, tank diameter and slurry properties on the jet axial velocity. The tanks used in the experimental work had diameters of 0.3 m (1-ft) and 2.13 m (7-ft). The fluids emerged from nozzles of 0.003 m and 0.01 m in diameter, 1/8-inch and 3/8-inch respectively. The examined slurries were non-Newtonian and contained 5 weight percent total insoluble solids. The axial velocities along the centerline of a submerged jet stream were measured at different jet flow rates andmore » at various distances from the nozzle orifice (16 to 200 nozzle diameters) utilizing electromagnetic velocity meter. A new simplified correlation was developed to describe the jet axial velocity in submerged jet stirred tanks utilizing more than 350 data points. The Buckingham Pi theorem and non-linear regression method of multivariate approximation, in conjunction with the Gauss-Jordan elimination method, were used to develop the new correlation. The new correlation agreed well with the experimental data obtained from the current study. Good agreement was also possible with literature data except at large distances from the nozzle as the model slightly overestimated the jet axial velocity. The proposed correlation incorporates the contributions of system geometry, fluid properties, and external forces. Furthermore, it provides reasonable estimates of jet axial velocity. (authors)« less

Anticipated and zero-lag synchronization in motifs of delay-coupled systems

NASA Astrophysics Data System (ADS)

Mirasso, Claudio R.; Carelli, Pedro V.; Pereira, Tiago; Matias, Fernanda S.; Copelli, Mauro

2017-11-01

Anticipated and zero-lag synchronization have been observed in different scientific fields. In the brain, they might play a fundamental role in information processing, temporal coding and spatial attention. Recent numerical work on anticipated and zero-lag synchronization studied the role of delays. However, an analytical understanding of the conditions for these phenomena remains elusive. In this paper, we study both phenomena in systems with small delays. By performing a phase reduction and studying phase locked solutions, we uncover the functional relation between the delay, excitation and inhibition for the onset of anticipated synchronization in a sender-receiver-interneuron motif. In the case of zero-lag synchronization in a chain motif, we determine the stability conditions. These analytical solutions provide an excellent prediction of the phase-locked regimes of Hodgkin-Huxley models and Roessler oscillators.

[Effects of orthokeratology lenses on the magnitude of accommodative lag and accommodativeconvergence/accommodation].

PubMed

Ren, Qiujin; Yue, Hui; Zhou, Qing

2016-02-01

To evaluate the change in accommodative lag and accommodation convergence/accommodation (AC/A) after patients with myopia wear orthokeratology lenses. 
 A total of 48 myopic subjects (a test group), who wore orthokeratology lenses regularly, and 48 myopic subjects (a control group), who wore spectacles regularly, were enrolled for this study from January 2011 to January 2013 in Optometric Center, the Forth Hospital of Changsha. Accommodative lag was measured by fused cross cylinder method, where the patients should gaze at the front optotypes 40 cm away. Gradient of the AC/A ratio was measured by Von Grafe method to check closer distance heterophoria. Accommodative lag and AC/A ratio were analyzed by statistics.
 After 1-year follow-up, accommodative lag and AC/A rate in patients with low or moderate myopia in the test group was decreased in 1, 3, 6 months or 1 year compared with that in the control group (P<0.05). 
 Compared with spectacles, orthokeratology lenses are able to decrease accommodative lag and high AC/A rate in patients with low or moderate myopia. The relationship between accommodation and convergence is improved by orthokeratology lenses. Orthokeratology is an effective way to control myopia.

The Reverberation Lag in the Low-mass X-ray Binary H1743-322

NASA Astrophysics Data System (ADS)

De Marco, Barbara; Ponti, Gabriele

2016-07-01

The evolution of the inner accretion flow of a black hole X-ray binary during an outburst is still a matter of active research. X-ray reverberation lags are powerful tools for constraining disk-corona geometry. We present a study of X-ray lags in the black hole transient H1743-322. We compared the results obtained from analysis of all the publicly available XMM-Newton observations. These observations were carried out during two different outbursts that occurred in 2008 and 2014. During all the observations the source was caught in the hard state and at similar luminosities ({L}3-10{keV}/{L}{Edd}˜ 0.004). We detected a soft X-ray lag of ˜60 ms, most likely due to thermal reverberation. We did not detect any significant change of the lag amplitude among the different observations, indicating a similar disk-corona geometry at the same luminosity in the hard state. On the other hand, we observe significant differences between the reverberation lag detected in H1743-322 and in GX 339-4 (at similar luminosities in the hard state), which might indicate variations of the geometry from source to source.

Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation

PubMed Central

Sega, Emanuela I.; Leveson-Gower, Dennis B.; Florek, Mareike; Schneidawind, Dominik; Luong, Richard H.; Negrin, Robert S.

2014-01-01

Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cell responses after bone marrow transplantation. We demonstrate that Lag-3 deficient Tcon (Lag-3−/− Tcon) induce significantly more severe GVHD than wild type (WT) Tcon and that the absence of Lag-3 on CD4 but not CD8 T cells is responsible for exacerbating GVHD. Lag-3−/− Tcon exhibited increased activation and proliferation as indicated by CFSE and bioluminescence imaging analyses and higher levels of activation markers such as CD69, CD107a, granzyme B, and Ki-67 as well as production of IL-10 and IFN-g early after transplantation. Lag-3−/− Tcon were less responsive to suppression by WT Treg as compared to WT Tcon. The absence of Lag-3, however, did not impair Treg function as both Lag-3−/− and WT Treg equally suppress the proliferation of Tcon in vitro and in vivo and protect against GVHD. Further, we demonstrate that allogeneic Treg acquire recipient MHC class II molecules through a process termed trogocytosis. As MHC class II is a ligand for Lag-3, we propose a novel suppression mechanism employed by Treg involving the acquisition of host MHC-II followed by the engagement of Lag-3 on T cells. These studies demonstrate for the first time the biologic function of Lag-3 expression on conventional and regulatory T cells in GVHD and identify Lag-3 as an important regulatory molecule involved in alloreactive T cell proliferation and activation after bone marrow transplantation. PMID:24475140

An investigation of the lag between the start of research and the development of new technology

NASA Technical Reports Server (NTRS)

Glass, S. E.

1982-01-01

The lag which occurs between the start of NASA-sponsored research and the development of new technology is addressed. A possible common gestation period is examined. The lags vary from one to zero years. The observed lag as it relates to patent applications is shorter than the lag as it relates to invention disclosures. The sequential hypothesis testing showed that invention disclosures correlated better to the measures of research effort used then did patent applications.

AC electrified jets in a flow-focusing device: Jet length scaling

PubMed Central

García-Sánchez, Pablo; Alzaga-Gimeno, Javier; Baret, Jean-Christophe

2016-01-01

We use a microfluidic flow-focusing device with integrated electrodes for controlling the production of water-in-oil drops. In a previous work, we reported that very long jets can be formed upon application of AC fields. We now study in detail the appearance of the long jets as a function of the electrical parameters, i.e., water conductivity, signal frequency, and voltage amplitude. For intermediate frequencies, we find a threshold voltage above which the jet length rapidly increases. Interestingly, this abrupt transition vanishes for high frequencies of the signal and the jet length grows smoothly with voltage. For frequencies below a threshold value, we previously reported a transition from a well-behaved uniform jet to highly unstable liquid structures in which axisymmetry is lost rather abruptly. These liquid filaments eventually break into droplets of different sizes. In this work, we characterize this transition with a diagram as a function of voltage and liquid conductivity. The electrical response of the long jets was studied via a distributed element circuit model. The model allows us to estimate the electric potential at the tip of the jet revealing that, for any combination of the electrical parameters, the breakup of the jet occurs at a critical value of this potential. We show that this voltage is around 550 V for our device geometry and choice of flow rates. PMID:27375826

AC electrified jets in a flow-focusing device: Jet length scaling.

PubMed

Castro-Hernández, Elena; García-Sánchez, Pablo; Alzaga-Gimeno, Javier; Tan, Say Hwa; Baret, Jean-Christophe; Ramos, Antonio

2016-07-01

We use a microfluidic flow-focusing device with integrated electrodes for controlling the production of water-in-oil drops. In a previous work, we reported that very long jets can be formed upon application of AC fields. We now study in detail the appearance of the long jets as a function of the electrical parameters, i.e., water conductivity, signal frequency, and voltage amplitude. For intermediate frequencies, we find a threshold voltage above which the jet length rapidly increases. Interestingly, this abrupt transition vanishes for high frequencies of the signal and the jet length grows smoothly with voltage. For frequencies below a threshold value, we previously reported a transition from a well-behaved uniform jet to highly unstable liquid structures in which axisymmetry is lost rather abruptly. These liquid filaments eventually break into droplets of different sizes. In this work, we characterize this transition with a diagram as a function of voltage and liquid conductivity. The electrical response of the long jets was studied via a distributed element circuit model. The model allows us to estimate the electric potential at the tip of the jet revealing that, for any combination of the electrical parameters, the breakup of the jet occurs at a critical value of this potential. We show that this voltage is around 550 V for our device geometry and choice of flow rates.

A longitudinal mediation analysis of the effect of negative-self-schemas on positive symptoms via negative affect.

PubMed

Jaya, E S; Ascone, L; Lincoln, T M

2018-06-01

Cognitive models postulate that negative-self-schemas (NSS) cause and maintain positive symptoms and that negative affect mediates this link. However, only few studies have tested the temporal mediation claim systematically using an appropriate design. A longitudinal cohort design in an online community sample (N = 962) from Germany, Indonesia, and the USA was used. NSS, negative affect and positive symptoms were measured at four time-points (T0-T3) over a 1-year period. Cross-lagged panel and longitudinal mediation analyses with structural equation modeling were used to test the temporal mediation. Independent cross-lagged panel models showed a significant unidirectional longitudinal path from NSS to positive symptoms (T2-T3, β = 0.18, p < 0.01) and bidirectional longitudinal associations from NSS to negative affect (T0-T1, γ = 0.14, p < 0.01) and vice versa (T0-T1, γ = 0.19, p < 0.01). There was also a significant indirect pathway from NSS at baseline via negative affect at T1 and T2 to positive symptoms at T3 (unstandardized indirect effect coefficient = 0.020, p < 0.05, BCa CI 0.004-0.035), indicating mediation. Our findings support the postulated affective pathway from NSS to positive symptoms via negative affect. Specifically, our data indicate that NSS and negative affect influence each other and build up over the course of several months before leading on to positive symptoms. We conclude that interrupting this process by targeting NSS and negative affect early in the process could be a promising strategy to prevent the exacerbation of positive symptoms.

Leading and lagging indicators of occupational health and safety: The moderating role of safety leadership.

PubMed

Sheehan, Cathy; Donohue, Ross; Shea, Tracey; Cooper, Brian; Cieri, Helen De

2016-07-01

In response to the call for empirical evidence of a connection between leading and lagging indicators of occupational health and safety (OHS), the first aim of the current research is to consider the association between leading and lagging indicators of OHS. Our second aim is to investigate the moderating effect of safety leadership on the association between leading and lagging indicators. Data were collected from 3578 employees nested within 66 workplaces. Multi-level modelling was used to test the two hypotheses. The results confirm an association between leading and lagging indicators of OHS as well as the moderating impact of middle management safety leadership on the direct association. The association between leading and lagging indicators provides OHS practitioners with useful information to substantiate efforts within organisations to move away from a traditional focus on lagging indicators towards a preventative focus on leading indicators. The research also highlights the important role played by middle managers and the value of OHS leadership development and investment at the middle management level. Copyright © 2016 Elsevier Ltd. All rights reserved.

Analysis and IbM simulation of the stages in bacterial lag phase: basis for an updated definition.

PubMed

Prats, Clara; Giró, Antoni; Ferrer, Jordi; López, Daniel; Vives-Rego, Josep

2008-05-07

The lag phase is the initial phase of a culture that precedes exponential growth and occurs when the conditions of the culture medium differ from the pre-inoculation conditions. It is usually defined by means of cell density because the number of individuals remains approximately constant or slowly increases, and it is quantified with the lag parameter lambda. The lag phase has been studied through mathematical modelling and by means of specific experiments. In recent years, Individual-based Modelling (IbM) has provided helpful insights into lag phase studies. In this paper, the definition of lag phase is thoroughly examined. Evolution of the total biomass and the total number of bacteria during lag phase is tackled separately. The lag phase lasts until the culture reaches a maximum growth rate both in biomass and cell density. Once in the exponential phase, both rates are constant over time and equal to each other. Both evolutions are split into an initial phase and a transition phase, according to their growth rates. A population-level mathematical model is presented to describe the transitional phase in cell density. INDividual DIScrete SIMulation (INDISIM) is used to check the outcomes of this analysis. Simulations allow the separate study of the evolution of cell density and total biomass in a batch culture, they provide a depiction of different observed cases in lag evolution at the individual-cell level, and are used to test the population-level model. The results show that the geometrical lag parameter lambda is not appropriate as a universal definition for the lag phase. Moreover, the lag phase cannot be characterized by a single parameter. For the studied cases, the lag phases of both the total biomass and the population are required to fully characterize the evolution of bacterial cultures. The results presented prove once more that the lag phase is a complex process that requires a more complete definition. This will be possible only after the phenomena

A forward bias method for lag correction of an a-Si flat panel detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Starman, Jared; Tognina, Carlo; Partain, Larry

2012-01-15

Purpose: Digital a-Si flat panel (FP) x-ray detectors can exhibit detector lag, or residual signal, of several percent that can cause ghosting in projection images or severe shading artifacts, known as the radar artifact, in cone-beam computed tomography (CBCT) reconstructions. A major contributor to detector lag is believed to be defect states, or traps, in the a-Si layer of the FP. Software methods to characterize and correct for the detector lag exist, but they may make assumptions such as system linearity and time invariance, which may not be true. The purpose of this work is to investigate a new hardwaremore » based method to reduce lag in an a-Si FP and to evaluate its effectiveness at removing shading artifacts in CBCT reconstructions. The feasibility of a novel, partially hardware based solution is also examined. Methods: The proposed hardware solution for lag reduction requires only a minor change to the FP. For pulsed irradiation, the proposed method inserts a new operation step between the readout and data collection stages. During this new stage the photodiode is operated in a forward bias mode, which fills the defect states with charge. A Varian 4030CB panel was modified to allow for operation in the forward bias mode. The contrast of residual lag ghosts was measured for lag frames 2 and 100 after irradiation ceased for standard and forward bias modes. Detector step response, lag, SNR, modulation transfer function (MTF), and detective quantum efficiency (DQE) measurements were made with standard and forward bias firmware. CBCT data of pelvic and head phantoms were also collected. Results: Overall, the 2nd and 100th detector lag frame residual signals were reduced 70%-88% using the new method. SNR, MTF, and DQE measurements show a small decrease in collected signal and a small increase in noise. The forward bias hardware successfully reduced the radar artifact in the CBCT reconstruction of the pelvic and head phantoms by 48%-81%. Conclusions: Overall

Simulation of Sweep-Jet Flow Control, Single Jet and Full Vertical Tail

NASA Technical Reports Server (NTRS)

Childs, Robert E.; Stremel, Paul M.; Garcia, Joseph A.; Heineck, James T.; Kushner, Laura K.; Storms, Bruce L.

2016-01-01

This work is a simulation technology demonstrator, of sweep jet flow control used to suppress boundary layer separation and increase the maximum achievable load coefficients. A sweep jet is a discrete Coanda jet that oscillates in the plane parallel to an aerodynamic surface. It injects mass and momentum in the approximate streamwise direction. It also generates turbulent eddies at the oscillation frequency, which are typically large relative to the scales of boundary layer turbulence, and which augment mixing across the boundary layer to attack flow separation. Simulations of a fluidic oscillator, the sweep jet emerging from a nozzle downstream of the oscillator, and an array of sweep jets which suppresses boundary layer separation are performed. Simulation results are compared to data from a dedicated validation experiment of a single oscillator and its sweep jet, and from a wind tunnel test of a full-scale Boeing 757 vertical tail augmented with an array of sweep jets. A critical step in the work is the development of realistic time-dependent sweep jet inflow boundary conditions, derived from the results of the single-oscillator simulations, which create the sweep jets in the full-tail simulations. Simulations were performed using the computational fluid dynamics (CFD) solver Overow, with high-order spatial discretization and a range of turbulence modeling. Good results were obtained for all flows simulated, when suitable turbulence modeling was used.

Sensitivity of jet substructure to jet-induced medium response

NASA Astrophysics Data System (ADS)

Milhano, Guilherme; Wiedemann, Urs Achim; Zapp, Korinna Christine

2018-04-01

Jet quenching in heavy ion collisions is expected to be accompanied by recoil effects, but unambiguous signals for the induced medium response have been difficult to identify so far. Here, we argue that modern jet substructure measurements can improve this situation qualitatively since they are sensitive to the momentum distribution inside the jet. We show that the groomed subjet shared momentum fraction zg, and the girth of leading and subleading subjets signal recoil effects with dependencies that are absent in a recoilless baseline. We find that recoil effects can explain most of the medium modifications to the zg distribution observed in data. Furthermore, for jets passing the Soft Drop Condition, recoil effects induce in the differential distribution of subjet separation ΔR12 a characteristic increase with ΔR12, and they introduce a characteristic enhancement of the girth of the subleading subjet with decreasing zg. We explain why these qualitatively novel features, that we establish in JEWEL+PYTHIA simulations, reflect generic physical properties of recoil effects that should therefore be searched for as telltale signatures of jet-induced medium response.

Early biometric lag in the prediction of small for gestational age neonates and preeclampsia.

PubMed

Schwartz, Nadav; Pessel, Cara; Coletta, Jaclyn; Krieger, Abba M; Timor-Tritsch, Ilan E

2011-01-01

An early fetal growth lag may be a marker of future complications. We sought to determine the utility of early biometric variables in predicting adverse pregnancy outcomes. In this retrospective cohort study, the crown-rump length at 11 to 14 weeks and the head circumference, biparietal diameter, abdominal circumference, femur length, humerus length, transverse cerebellar diameter, and estimated fetal weight at 18 to 24 weeks were converted to an estimated gestational age using published regression formulas. Sonographic fetal growth (difference between each biometric gestational age and the crown-rump length gestational age) minus expected fetal growth (number of days elapsed between the two scans) yielded the biometric growth lag. These lags were tested as predictors of small for gestational age (SGA) neonates (≤10th percentile) and preeclampsia. A total of 245 patients were included. Thirty-two (13.1%) delivered an SGA neonate, and 43 (17.6%) had the composite outcome. The head circumference, biparietal diameter, abdominal circumference, and estimated fetal weight lags were identified as significant predictors of SGA neonates after adjusted analyses (P < .05). The addition of either the estimated fetal weight or abdominal circumference lag to maternal characteristics alone significantly improved the performance of the predictive model, achieving areas under the curve of 0.72 and 0.74, respectively. No significant association was found between the biometric lag variables and the development of preeclampsia. Routinely available biometric data can be used to improve the prediction of adverse outcomes such as SGA. These biometric lags should be considered in efforts to develop screening algorithms for adverse outcomes.

Effects of timber harvesting on the lag time of Caspar Creek watershed

Treesearch

Karen Hardison Sendek

1985-01-01

Abstract - Hydrograph lag time was analyzed to determine changes after road construction and after selective, tractor-yarded logging in a Caspar Creek watershed, Mendocino County, California. The paired watershed technique was used. Hydrograph lag time for each storm was the time separation between the midpoint of precipitation and the time coordinate of the runoff...

Parenting stress and depressive symptoms in postpartum mothers: Bidirectional or unidirectional effects?

PubMed Central

Thomason, Elizabeth; Volling, Brenda L.; Flynn, Heather A.; McDonough, Susan C.; Marcus, Sheila M.; Lopez, Juan F.; Vazquez, Delia M.

2015-01-01

Despite the consistent link between parenting stress and postpartum depressive symptoms, few studies have explored the relationships longitudinally. The purpose of this study was to test bidirectional and unidirectional models of depressive symptoms and parenting stress. Uniquely, three specific domains of parenting stress were examined: parental distress, difficult child stress, and parent–child dysfunctional interaction (PCDI). One hundred and five women completed the Beck Depression Inventory and the Parenting Stress Index–Short Form at 3, 7, and 14 months after giving birth. Structural equation modeling revealed that total parenting stress predicted later depressive symptoms, however, there were different patterns between postpartum depressive symptoms and different types of parenting stress. A unidirectional model of parental distress predicting depressive symptoms best fit the data, with significant stability paths but non-significant cross-lagged paths. A unidirectional model of depressive symptoms predicted significant later difficult child stress. No model fit well with PCDI. Future research should continue to explore the specific nature of the associations of postpartum depression and different types of parenting stress on infant development and the infant–mother relationship. PMID:24956500

Exploring lag times between monthly atmospheric deposition and stream chemistry in Appalachian forests using cross-correlation

NASA Astrophysics Data System (ADS)

DeWalle, David R.; Boyer, Elizabeth W.; Buda, Anthony R.

2016-12-01

Forecasts of ecosystem changes due to variations in atmospheric emissions policies require a fundamental understanding of lag times between changes in chemical inputs and watershed response. Impacts of changes in atmospheric deposition in the United States have been documented using national and regional long-term environmental monitoring programs beginning several decades ago. Consequently, time series of weekly NADP atmospheric wet deposition and monthly EPA-Long Term Monitoring stream chemistry now exist for much of the Northeast which may provide insights into lag times. In this study of Appalachian forest basins, we estimated lag times for S, N and Cl by cross-correlating monthly data from four pairs of stream and deposition monitoring sites during the period from 1978 to 2012. A systems or impulse response function approach to cross-correlation was used to estimate lag times where the input deposition time series was pre-whitened using regression modeling and the stream response time series was filtered using the deposition regression model prior to cross-correlation. Cross-correlations for S were greatest at annual intervals over a relatively well-defined range of lags with the maximum correlations occurring at mean lags of 48 months. Chloride results were similar but more erratic with a mean lag of 57 months. Few high-correlation lags for N were indicated. Given the growing availability of atmospheric deposition and surface water chemistry monitoring data and our results for four Appalachian basins, further testing of cross-correlation as a method of estimating lag times on other basins appears justified.

Minimization of diauxic growth lag-phase for high-efficiency biogas production.

PubMed

Kim, Min Jee; Kim, Sang Hun

2017-02-01

The objective of this study was to develop a minimization method of a diauxic growth lag-phase for the biogas production from agricultural by-products (ABPs). Specifically, the effects of proximate composition on the biogas production and degradation rates of the ABPs were investigated, and a new method based on proximate composition combinations was developed to minimize the diauxic growth lag-phase. Experiments were performed using biogas potential tests at a substrate loading of 2.5 g VS/L and feed to microorganism ratio (F/M) of 0.5 under the mesophilic condition. The ABPs were classified based on proximate composition (carbohydrate, protein, and fat etc.). The biogas production patterns, lag phase, and times taken for 90% biogas production (T90) were used for the evaluation of the biogas production with biochemical methane potential (BMP) test. The high- or medium-carbohydrate and low-fat ABPs (cheese whey, cabbage, and skim milk) showed a single step digestion process and low-carbohydrate and high-fat ABPs (bean curd and perilla seed) showed a two-step digestion process. The mixture of high-fat ABPs and high-carbohydrate ABPs reduced the lag-phase and increased the biogas yield more than that from single ABP by 35-46%. Copyright © 2016 Elsevier Ltd. All rights reserved.

How to compare cross-lagged associations in a multilevel autoregressive model.

PubMed

Schuurman, Noémi K; Ferrer, Emilio; de Boer-Sonnenschein, Mieke; Hamaker, Ellen L

2016-06-01

By modeling variables over time it is possible to investigate the Granger-causal cross-lagged associations between variables. By comparing the standardized cross-lagged coefficients, the relative strength of these associations can be evaluated in order to determine important driving forces in the dynamic system. The aim of this study was twofold: first, to illustrate the added value of a multilevel multivariate autoregressive modeling approach for investigating these associations over more traditional techniques; and second, to discuss how the coefficients of the multilevel autoregressive model should be standardized for comparing the strength of the cross-lagged associations. The hierarchical structure of multilevel multivariate autoregressive models complicates standardization, because subject-based statistics or group-based statistics can be used to standardize the coefficients, and each method may result in different conclusions. We argue that in order to make a meaningful comparison of the strength of the cross-lagged associations, the coefficients should be standardized within persons. We further illustrate the bivariate multilevel autoregressive model and the standardization of the coefficients, and we show that disregarding individual differences in dynamics can prove misleading, by means of an empirical example on experienced competence and exhaustion in persons diagnosed with burnout. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Evaluation of the limiting antigen avidity EIA (LAg) in people who inject drugs in Greece.

PubMed

Nikolopoulos, G K; Katsoulidou, A; Kantzanou, M; Rokka, C; Tsiara, C; Sypsa, V; Paraskevis, D; Psichogiou, M; Friedman, S; Hatzakis, A

2017-01-01

This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) ⩽1·5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false recent (PFR) were estimated in 28 seroconverters and in 366 samples collected >6 months after HIV diagnosis, respectively. The association between LAg ODn and HIV RNA level was evaluated in 232 persons. The PTR was 85·7%. The PFR was 20·8% but fell to 5·9% in samples from treatment-naive individuals with long-standing infection (>1 year), and to 0 in samples with the circulating recombinant form CRF35 AD. A LAg-based algorithm with a PFR of 3·3% estimated a similar incidence trend to that calculated by analyses based on HIV-1 seroconversions. In recently infected persons indicated by LAg, the median log10 HIV RNA level was high (5·30, interquartile range 4·56-5·90). LAg can help identify highly infectious HIV(+) individuals as it accurately identifies recent infections and is correlated with the HIV RNA level. It can also produce reliable estimates of HIV-1 incidence.

Characteristics of transverse hydrogen jet in presence of multi air jets within scramjet combustor

NASA Astrophysics Data System (ADS)

Barzegar Gerdroodbary, M.; Fallah, Keivan; Pourmirzaagha, H.

2017-03-01

In this article, three-dimensional simulation is performed to investigate the effects of micro air jets on mixing performances of cascaded hydrogen jets within a scramjet combustor. In order to compare the efficiency of this technique, constant total fuel rate is injected through one, four, eight and sixteen arrays of portholes in a Mach 4.0 crossflow with a fuel global equivalence ratio of 0.5. In this method, micro air jets are released within fuel portholes to augment the penetration in upward direction. Extensive studies were performed by using the Reynolds-averaged Navier-Stokes equations with Menter's Shear Stress Transport (SST) turbulence model. Numerical studies on various air and fuel arrangements are done and the mixing rate and penetration are comprehensively investigated. Also, the flow feature of the fuel and air jets for different configuration is revealed. According to the obtained results, the influence of the micro air jets is significant and the presence of micro air jets increases the mixing rate about 116%, 77%, 56% and 41% for single, 4, 8 and 16 multi fuel jets, respectively. The maximum mixing rate of the hydrogen jet is obtained when the air jets are injected within the sixteen multi fuel jets. According to the circulation analysis of the flow for different air and fuel arrangements, it was found that the effects of air jets on flow structure are varied in various conditions and the presence of the micro jet highly intensifies the circulation in the case of 8 and 16 multi fuel jets.

The remarkable AGN jets

NASA Astrophysics Data System (ADS)

Komissarov, Serguei

The jets from active galactic nuclei exhibit stability which seems to be far superior compared to that of terrestrial and laboratory jets. They manage to propagate over distances up to a billion of initial jet radii. Yet this may not be an indication of some exotic physics but mainly a reflection of the specific environment these jets propagate through. The key property of this environment is a rapid decline of density and pressure along the jet, which promotes its rapid expansion. Such an expansion can suppress global instabilities, which require communication across the jet, and hence ensure its survival over huge distances. At kpc scales, some AGN jets do show signs of strong instabilities and even turn into plumes. This could be a result of the flattening of the external pressure distribution in their host galaxies or inside the radio lobes. In this regard, we discuss the possible connection between the stability issue and the Fanaroff-Riley classification of extragalactic radio sources. The observations of AGN jets on sub-kpc scale do not seem to support their supposed lack of causal connectivity. When interpreted using simple kinematic models, they reveal a rather perplexing picture with more questions than answers on the jets dynamics.

Peripheral Design of Progressive Addition Lenses and the Lag of Accommodation in Myopes.

PubMed

Schilling, Tim; Ohlendorf, Arne; Varnas, Saulius R; Wahl, Siegfried

2017-07-01

Insufficient accommodative response is assumed to result in myopia progression. We have investigated if the accommodative lag in myopes is different between a single vision lens (SVL) and the progressive addition lens PAL 2, clinically trialled for its ability to reduce progression of myopia, and if there exist differences in accommodative lag between PAL 2 and other PALs with the same addition power (+1.50 D). The influence of spherical SVL and four different designs of PALs that differ in the near zone width (PAL 1) or that have different signs and magnitude of horizontal gradients of mean power adjacent to their near vision zones (PAL 3 and PAL 4) on the accommodative response was investigated for different near viewing distances (40, 33, and 25 cm) in 31 subjects, aged 18 to 25 years. The SVL correction resulted in insufficient accommodative response for the near object viewing distances tested. PAL 2 did significantly reduce accommodative lag for all near object distances tested. The PAL design with a more negative horizontal mean power gradient (PAL 4) provided a lower lag of accommodation when compared with PAL 2 at the shortest object distance of 25 cm (P = 0.03) and was able to reduce the lag of accommodation to a level below the depth of focus for the higher near working distances tested. Designs of PAL with more negative horizontal mean power gradients are the most effective in lowering the lag of accommodation in myopes. This could make them good test candidates for myopia control applications.

The lag effects and vulnerabilities of temperature effects on cardiovascular disease mortality in a subtropical climate zone in China.

PubMed

Huang, Jixia; Wang, Jinfeng; Yu, Weiwei

2014-04-11

This research quantifies the lag effects and vulnerabilities of temperature effects on cardiovascular disease in Changsha--a subtropical climate zone of China. A Poisson regression model within a distributed lag nonlinear models framework was used to examine the lag effects of cold- and heat-related CVD mortality. The lag effect for heat-related CVD mortality was just 0-3 days. In contrast, we observed a statistically significant association with 10-25 lag days for cold-related CVD mortality. Low temperatures with 0-2 lag days increased the mortality risk for those ≥65 years and females. For all ages, the cumulative effects of cold-related CVD mortality was 6.6% (95% CI: 5.2%-8.2%) for 30 lag days while that of heat-related CVD mortality was 4.9% (95% CI: 2.0%-7.9%) for 3 lag days. We found that in Changsha city, the lag effect of hot temperatures is short while the lag effect of cold temperatures is long. Females and older people were more sensitive to extreme hot and cold temperatures than males and younger people.

A Comparison of Several Methods of Measuring Ignition Lag in a Compression-ignition Engine

NASA Technical Reports Server (NTRS)

Spanogle, J A

1934-01-01

The ignition lag of a fuel oil in the combustion chamber of a high speed compression-ignition engine was measured by three different methods. The start of injection of the fuel as observed with a Stoborama was taken as the start of the period of ignition lag in all cases. The end of the period of ignition lag was determined by observation of the appearance of incandescence in the combustion chamber, by inspection of a pressure-time card for evidence of pressure rise, and by analysis of the indicator card for evidence of the combustion of a small but definite quantity of fuel. A comparison of the values for ignition lags obtained by these three methods indicates that the appearance of incandescence is later than other evidences of the start of combustion, that visual inspection of a pressure-time diagram gives consistent and usable values with a minimum requirement of time and/or apparatus, and that analysis of the indicator card is not worth while for ignition lag alone.

Estimation of watershed lag times and times of concentration for the Kansas City Area : technical summary.

DOT National Transportation Integrated Search

2016-04-01

The new lag-time equation for the Kansas City area performs better than the 2001 KU-KDOT equation for urban lag time, which was developed from a study of 14 gaged watersheds in Johnson County (McEnroe & Zhao, 2001). The main advantage of the new lag-...

Magnetosheath jets: MMS observations of internal structures and jet interactions with ambient plasma

NASA Astrophysics Data System (ADS)

Plaschke, F.; Karlsson, T.; Hietala, H.; Archer, M. O.; Voros, Z.; Nakamura, R.; Magnes, W.; Baumjohann, W.; Torbert, R. B.; Russell, C. T.; Giles, B. L.

2017-12-01

The dayside magnetosheath downstream of the quasi-parallel bow shock is commonly permeated by high-speed jets. Under low IMF cone angle conditions, large scale jets alone (with cross-sectional diameters of over 2 Earth radii) have been found to impact the subsolar magnetopause once every 6 minutes - smaller scale jets occurring much more frequently. The consequences of jet impacts on the magnetopause can be significant: they may trigger local reconnection and waves, alter radiation belt electron drift paths, disturb the geomagnetic field, and potentially generate diffuse throat aurora at the dayside ionosphere. Although some basic statistical properties of jets are well-established, their internal structure and interactions with the surrounding magnetosheath plasma are rather unknown. We present Magnetospheric Multiscale (MMS) observations which reveal a rich jet-internal structure of high-amplitude plasma moment and magnetic field variations and associated currents. These variations/structures are generally found to be in thermal and magnetic pressure balance; they mostly (but not always) convect with the plasma flow. Small velocity differences between plasma and structures are revealed via four-spacecraft timing analysis. Inside a jet core region, where the plasma velocity maximizes, structures are found to propagate forward (i.e., with the jet), whereas backward propagation is found outside that core region. Although super-magnetosonic flows are detected by MMS in the spacecraft frame of reference, no fast shock is seen as the jet plasma is sub-magnetosonic with respect to the ambient magnetosheath plasma. Instead, the fast jet plasma pushes ambient magnetosheath plasma ahead of the jet out of the way, possibly generating anomalous sunward flows in the vicinity, and modifies the magnetic field aligning it with the direction of jet propagation.

Deformations of free jets

NASA Astrophysics Data System (ADS)

Paruchuri, Srinivas

This thesis studies three different problems. First we demonstrate that a flowing liquid jet can be controllably split into two separate subfilaments through the applications of a sufficiently strong tangential stress to the surface of the jet. In contrast, normal stresses can never split a liquid jet. We apply these results to observations of uncontrolled splitting of jets in electric fields. The experimental realization of controllable jet splitting would provide an entirely novel route for producing small polymeric fibers. In the second chapter we present an analytical model for the bending of liquid jets and sheets from temperature gradients, as recently observed by Chwalek et al. [Phys. Fluids, 14, L37 (2002)]. The bending arises from a local couple caused by Marangoni forces. The dependence of the bending angle on experimental parameters is presented, in qualitative agreement with reported experiments. The methodology gives a simple framework for understanding the mechanisms for jet and sheet bending. In chapter 4 we address the discrepancy between hydrodynamic theory of liquid jets, and the snap-off of narrow liquid jets observed in molecular dynamics (MD) simulations [23]. This has been previously attributed to the significant role of thermal fluctuations in nanofluidic systems. We argue that hydrodynamic description of such systems should include corrections to the Laplace pressure which result from the failure of the sharp interface assumption when the jet diameter becomes small enough. We show that this effect can in principle give rise to jet shapes similar to those observed in MD simulations, even when thermal fluctuations are completely neglected. Finally we summarize an algorithm developed to simulate droplet impact on a smooth surface.

Adolescents' Depressive Symptoms and Subsequent Technology-Based Interpersonal Behaviors: A Multi-Wave Study.

PubMed

Nesi, Jacqueline; Miller, Adam B; Prinstein, Mitchell J

2017-07-01

This study examined the longitudinal effects of adolescents' depressive symptoms on engagement in technology-based social comparison and feedback seeking (SCFS) behaviors. A total of 816 adolescents (54.7% girls; M age =14.1 at Time 1) participated at three times points, each one year apart. Adolescents reported technology-based SCFS, depressive symptoms, and frequencies of technology use (cell phones, Facebook, and Instagram). Multiple group (by gender) latent growth curve models examined concurrent and lagged effects of depressive symptoms on SCFS, controlling for adolescent's underlying trajectories of SCFS and overall frequencies of technology use. Results indicated that higher levels of depressive symptoms were concurrently associated with greater SCFS after accounting for adolescents' typical patterns of SCFS. For boys only, higher depressive symptoms were prospectively associated with later increases in SCFS. Results highlight the importance of social media as a unique context in which depressed adolescents may be at risk for maladaptive interpersonal behavior.

Summer Travel: Plan Ahead To Stay Healthy

MedlinePlus

... Twery says. “It’s especially important before and during travel to consciously schedule time to sleep.” Too little sleep leads to poor ... and their ability to meet the challenges of travel.” Jet lag is another sleep concern for travelers crossing multiple time zones. Jet lag is often more severe for ...

Effect of Repetition Lag on Priming of Unfamiliar Visual Objects in Young and Older Adults

PubMed Central

Gordon, Leamarie T.; Soldan, Anja; Thomas, Ayanna K.; Stern, Yaakov

2013-01-01

Across three experiments, we examined the effect of repetition lag on priming of unfamiliar visual objects in healthy young and older adults. Multiple levels of lag were examined, ranging from short (one to four intervening stimuli) to long (50+ intervening stimuli). In each experiment, subjects viewed a series of new and repeated line drawings of objects and decided whether they depicted structurally possible or impossible figures. Experiment 1 and 2 found similar levels of priming in young and older adults at short and medium lags. At the longer repetition lags (∼20+ intervening stimuli), older adults showed less overall priming, as measured by reaction time facilitation, than young adults. This indicates that older adults can rapidly encode unfamiliar three-dimensional objects to support priming at shorter lags; however, they cannot maintain these representations over longer intervals. In addition to repetition lag, we also explored the relationship between priming and cognitive reserve, as measured by education and verbal intelligence. In the older adults, higher levels of cognitive reserve were associated with greater reaction time priming, suggesting that cognitive reserve may mediate the relationship between aging and priming. PMID:23276220

Jets Galore

NASA Image and Video Library

2010-11-04

This enhanced image, one of the closest taken of comet Harley 2 by NASA EPOXI mission, shows jets and where they originate from the surface. There are jets outgassing from the sunward side, the night side, and along the terminator.

The Sloan Digital Sky Survey Reverberation Mapping Project: Composite Lags at z ≤ 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Jennifer; Shen, Yue; Horne, Keith

We present composite broad-line region (BLR) reverberation mapping lag measurements for H α , H β , He ii λ 4686, and Mg ii for a sample of 144, z ≲ 1 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Using only the 32-epoch spectroscopic light curves in the first six-month season of SDSS-RM observations, we compile correlation function measurements for individual objects and then coadd them to allow the measurement of the average lags for our sample at mean redshifts of 0.4 (for H α ) and ∼0.65 (for the other lines). At similar quasar luminositiesmore » and redshifts, the sample-averaged lag decreases in the order of Mg ii, H α , H β , and He ii. This decrease in lags is accompanied by an increase in the mean line width of the four lines, and is roughly consistent with the virialized motion for BLR gas in photoionization equilibrium. These are among the first RM measurements of stratified BLR structure at z > 0.3. Dividing our sample by luminosity, H α shows clear evidence of increasing lags with luminosity, consistent with the expectation from the measured BLR size–luminosity relation based on H β . The other three lines do not show a clear luminosity trend in their average lags due to the limited dynamic range of luminosity probed and the poor average correlation signals in the divided samples, a situation that will be improved with the incorporation of additional photometric and spectroscopic data from SDSS-RM. We discuss the utility and caveats of composite lag measurements for large statistical quasar samples with reverberation mapping data.« less

The Sloan Digital Sky Survey Reverberation Mapping Project: Composite Lags at z ≤ 1

NASA Astrophysics Data System (ADS)

Li, Jennifer; Shen, Yue; Horne, Keith; Brandt, W. N.; Greene, Jenny E.; Grier, C. J.; Ho, Luis C.; Kochanek, Chris; Schneider, Donald P.; Trump, Jonathan R.; Dawson, Kyle S.; Pan, Kaike; Bizyaev, Dmitry; Oravetz, Daniel; Simmons, Audrey; Malanushenko, Elena

2017-09-01

We present composite broad-line region (BLR) reverberation mapping lag measurements for Hα, Hβ, He II λ4686, and Mg II for a sample of 144, z ≲ 1 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Using only the 32-epoch spectroscopic light curves in the first six-month season of SDSS-RM observations, we compile correlation function measurements for individual objects and then coadd them to allow the measurement of the average lags for our sample at mean redshifts of 0.4 (for Hα) and ˜0.65 (for the other lines). At similar quasar luminosities and redshifts, the sample-averaged lag decreases in the order of Mg II, Hα, Hβ, and He II. This decrease in lags is accompanied by an increase in the mean line width of the four lines, and is roughly consistent with the virialized motion for BLR gas in photoionization equilibrium. These are among the first RM measurements of stratified BLR structure at z > 0.3. Dividing our sample by luminosity, Hα shows clear evidence of increasing lags with luminosity, consistent with the expectation from the measured BLR size-luminosity relation based on Hβ. The other three lines do not show a clear luminosity trend in their average lags due to the limited dynamic range of luminosity probed and the poor average correlation signals in the divided samples, a situation that will be improved with the incorporation of additional photometric and spectroscopic data from SDSS-RM. We discuss the utility and caveats of composite lag measurements for large statistical quasar samples with reverberation mapping data.

Hard-rock jetting. Part 2. Rock type decides jetting economics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pols, A.C.

1977-02-07

In Part 2, Koninklijke Shell Exploratie en Produktie Laboratorium presents the results of jet-drilling laminated formations. Shell concludes that (1) hard, laminated rock cannot be jet-drilled satisfactorily without additional mechanical cutting aids, (2) the increase in penetration rate with bit-pressure drop is much lower for impermeable rock than it is for permeable rock, (3) drilling mud can have either a positive or a negative effect on penetration rate in comparison with water, depending on the material drilled, and (4) hard, isotropic, sedimentary, impermeable rock can be drilled using jets at higher rates than with conventional means. However, jetting becomes profitablemore » only in the case of expensive rigs.« less

Lagging adaptation to warming climate in Arabidopsis thaliana.

PubMed

Wilczek, Amity M; Cooper, Martha D; Korves, Tonia M; Schmitt, Johanna

2014-06-03

If climate change outpaces the rate of adaptive evolution within a site, populations previously well adapted to local conditions may decline or disappear, and banked seeds from those populations will be unsuitable for restoring them. However, if such adaptational lag has occurred, immigrants from historically warmer climates will outperform natives and may provide genetic potential for evolutionary rescue. We tested for lagging adaptation to warming climate using banked seeds of the annual weed Arabidopsis thaliana in common garden experiments in four sites across the species' native European range: Valencia, Spain; Norwich, United Kingdom; Halle, Germany; and Oulu, Finland. Genotypes originating from geographic regions near the planting site had high relative fitness in each site, direct evidence for broad-scale geographic adaptation in this model species. However, genotypes originating in sites historically warmer than the planting site had higher average relative fitness than local genotypes in every site, especially at the northern range limit in Finland. This result suggests that local adaptive optima have shifted rapidly with recent warming across the species' native range. Climatic optima also differed among seasonal germination cohorts within the Norwich site, suggesting that populations occurring where summer germination is common may have greater evolutionary potential to persist under future warming. If adaptational lag has occurred over just a few decades in banked seeds of an annual species, it may be an important consideration for managing longer-lived species, as well as for attempts to conserve threatened populations through ex situ preservation.

Lagging adaptation to warming climate in Arabidopsis thaliana

PubMed Central

Wilczek, Amity M.; Cooper, Martha D.; Korves, Tonia M.; Schmitt, Johanna

2014-01-01

If climate change outpaces the rate of adaptive evolution within a site, populations previously well adapted to local conditions may decline or disappear, and banked seeds from those populations will be unsuitable for restoring them. However, if such adaptational lag has occurred, immigrants from historically warmer climates will outperform natives and may provide genetic potential for evolutionary rescue. We tested for lagging adaptation to warming climate using banked seeds of the annual weed Arabidopsis thaliana in common garden experiments in four sites across the species’ native European range: Valencia, Spain; Norwich, United Kingdom; Halle, Germany; and Oulu, Finland. Genotypes originating from geographic regions near the planting site had high relative fitness in each site, direct evidence for broad-scale geographic adaptation in this model species. However, genotypes originating in sites historically warmer than the planting site had higher average relative fitness than local genotypes in every site, especially at the northern range limit in Finland. This result suggests that local adaptive optima have shifted rapidly with recent warming across the species’ native range. Climatic optima also differed among seasonal germination cohorts within the Norwich site, suggesting that populations occurring where summer germination is common may have greater evolutionary potential to persist under future warming. If adaptational lag has occurred over just a few decades in banked seeds of an annual species, it may be an important consideration for managing longer-lived species, as well as for attempts to conserve threatened populations through ex situ preservation. PMID:24843140

Calibration of Watershed Lag Time Equation for Philippine Hydrology using RADARSAT Digital Elevation Models

NASA Astrophysics Data System (ADS)

Cipriano, F. R.; Lagmay, A. M. A.; Horritt, M.; Mendoza, J.; Sabio, G.; Punay, K. N.; Taniza, H. J.; Uichanco, C.

2015-12-01

Widespread flooding is a major problem in the Philippines. The country experiences heavy amount of rainfall throughout the year and several areas are prone to flood hazards because of its unique topography. Human casualties and destruction of infrastructure are just some of the damages caused by flooding and the Philippine government has undertaken various efforts to mitigate these hazards. One of the solutions was to create flood hazard maps of different floodplains and use them to predict the possible catastrophic results of different rain scenarios. To produce these maps with accurate output, different input parameters were needed and one of those is calculating hydrological components from topographical data. This paper presents how a calibrated lag time (TL) equation was obtained using measurable catchment parameters. Lag time is an essential input in flood mapping and is defined as the duration between the peak rainfall and peak discharge of the watershed. The lag time equation involves three measurable parameters, namely, watershed length (L), maximum potential retention (S) derived from the curve number, and watershed slope (Y), all of which were available from RADARSAT Digital Elevation Models (DEM). This approach was based on a similar method developed by CH2M Hill and Horritt for Taiwan, which has a similar set of meteorological and hydrological parameters with the Philippines. Rainfall data from fourteen water level sensors covering 67 storms from all the regions in the country were used to estimate the actual lag time. These sensors were chosen by using a screening process that considers the distance of the sensors from the sea, the availability of recorded data, and the catchment size. The actual lag time values were plotted against the values obtained from the Natural Resource Conservation Management handbook lag time equation. Regression analysis was used to obtain the final calibrated equation that would be used to calculate the lag time

Real jet effects on dual jets in a crossflow

NASA Technical Reports Server (NTRS)

Schetz, J. A.

1984-01-01

A 6-ft by 6-ft wind tunnel section was modification to accommodate the 7-ft wide NASA dual-jet flate model in an effort to determine the effects of nonuniform and/or noncircular jet exhaust profiles on the pressure field induced on a nearby surface. Tests completed yield surface pressure measurements for a 90 deg circular injector producing exit profiles representative of turbofan nozzles (such as the TF-34 nozzle). The measurements were obtained for both tandem and side-by-side jet configurations, jet spacing of S/D =2, and velocity ratios of R=2.2 and 4.0. Control tests at the same mass flow rate but with uniform exit velocity profiles were also conducted, for comparison purposes. Plots for 90 deg injection and R=2.2 show that the effects of exit velocity profile nonuniformity are quite significant.

Study Of Boosted W-Jets And Higgs-Jets With the SiFCC Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Shin-Shan; Chekanov, Sergei; Gray, Lindsey

We study the detector performance in the reconstruction of hadronically-decaying W bosons and Higgs bosons at very high energy proton colliders using a full GEANT4 simulation of the SiFCC detector. The W and Higgs bosons carry transverse momentum in the multi-TeV range, which results in collimated decay products that are reconstructed as a single jet. We present a measurement of the energy response and resolution of boosted W-jets and Higgs-jets and show the separation of two sub-jets within the boosted boson jet.

Temporal evolution of photon energy emitted from two-component advective flows: origin of time lag

NASA Astrophysics Data System (ADS)

Chatterjee, Arka; Chakrabarti, Sandip K.; Ghosh, Himadri

2017-12-01

X-ray time lag of black hole candidates contains important information regarding the emission geometry. Recently, study of time lags from observational data revealed very intriguing properties. To investigate the real cause of this lag behavior with energy and spectral states, we study photon paths inside a two-component advective flow (TCAF) which appears to be a satisfactory model to explain the spectral and timing properties. We employ the Monte Carlo simulation technique to carry out the Comptonization process. We use a relativistic thick disk in Schwarzschild geometry as the CENtrifugal pressure supported BOundary Layer (CENBOL) which is the Compton cloud. In TCAF, this is the post-shock region of the advective component. Keplerian disk on the equatorial plane which is truncated at the inner edge i.e. at the outer boundary of the CENBOL, acts as the soft photon source. Ray-tracing code is employed to track the photons to a distantly located observer. We compute the cumulative time taken by a photon during Comptonization, reflection and following the curved geometry on the way to the observer. Time lags between various hard and soft bands have been calculated. We study the variation of time lags with accretion rates, CENBOL size and inclination angle. Time lags for different energy channels are plotted for different inclination angles. The general trend of variation of time lag with QPO frequency and energy as observed in satellite data is reproduced.

Dripping and jetting regimes in co-flowing capillary jets: unforced measurements and response to driving

NASA Astrophysics Data System (ADS)

Baroud, Charles; Cordero, Maria-Luisa; Gallaire, Francois

2011-11-01

We study the breakup of drops in a co-flowing jet, within the confinement of a microfluidic channel. The breakup can occur right after the nozzle (dripping) or through the generation of a liquid jet that breaks up a long distance from the nozzle (jetting). Traditionally, these two regimes have been considered to reflect an absolutely unstable jet or a convectively unstable jet, respectively. We first provide measurements of the frequency of oscillation and breakup of the liquid jet; the dispersion relation thus obtained compares well with existing theories for convective instabilities in the case of the jetting regime. However, the theories in the absolutely unstable mode fail to predict the evolution of the frequency and drop size in the dripping regime. We also test the jet response to an external forcing, using a focused laser to locally heat the jet. The dripping regime is found to be insensitive to the perturbation and the frequency of drop formation remains unaltered. In contrast, the jetting regime locks to the external frequency, which translates into a modification of the drop size in agreement with the dispersion relations. This confirms the convective nature of the jetting regime. Permanent address: Universidad de Chile.

Pulmonary function and respiratory symptoms in a population of airport workers.

PubMed

Tunnicliffe, W S; O'Hickey, S P; Fletcher, T J; Miles, J F; Burge, P S; Ayres, J G

1999-02-01

To assess the prevalence of respiratory symptoms and to measure spirometry in a sample of employees of Birmingham International Airport, United Kingdom, to examine whether occupational exposure to aircraft fuel or jet stream exhaust might be associated with respiratory symptoms or abnormalities of lung function. Cross sectional survey by questionnaire and on site measurement of lung function, skin prick tests, and exhaled carbon monoxide concentrations. Occupational exposure was assigned by job title, between group comparison were made by logistic regression analysis. 222/680 full time employees were studied (mean age 38.6 y, 63% male, 28% current smokers, 6% self reported asthma, 19% self reported hay fever). Upper and lower respiratory tract symptoms were common and 51% had one or more positive skin tests. There were no significant differences in lung function tests between exposure groups. Between group comparisons of respiratory symptoms were restricted to male members of the medium and high exposure groups. The adjusted odds ratio (OR) for cough with phlegm and runny nose were found to be significantly associated with high exposure (OR 3.5, 95% confidence interval (95% CI) 1.23 to 9.74 and 2.9, 1.32 to 6.40 respectively) when the measured confounding effects of age and smoking, and in the case of runny nose, self reported hay fever had been taken into account. There was no obvious association between high exposure and the presence of shortness of breath or wheeze, or for the symptoms of watering eyes or stuffy nose. These findings support an association in male airport workers, between high occupational exposures to aviation fuel or jet stream exhaust and excess upper and lower respiratory tract symptoms, in keeping with a respiratory irritant. It is more likely that these effects reflect exposure to exhaust rather than fuel, although the effects of an unmeasured agent cannot be discounted.

Validation of a reduced-order jet model for subsonic and underexpanded hydrogen jets

DOE PAGES

Li, Xuefang; Hecht, Ethan S.; Christopher, David M.

2016-01-01

Much effort has been made to model hydrogen releases from leaks during potential failures of hydrogen storage systems. A reduced-order jet model can be used to quickly characterize these flows, with low computational cost. Notional nozzle models are often used to avoid modeling the complex shock structures produced by the underexpanded jets by determining an “effective” source to produce the observed downstream trends. In our work, the mean hydrogen concentration fields were measured in a series of subsonic and underexpanded jets using a planar laser Rayleigh scattering system. Furthermore, we compared the experimental data to a reduced order jet modelmore » for subsonic flows and a notional nozzle model coupled to the jet model for underexpanded jets. The values of some key model parameters were determined by comparisons with the experimental data. Finally, the coupled model was also validated against hydrogen concentrations measurements for 100 and 200 bar hydrogen jets with the predictions agreeing well with data in the literature.« less

Resolving boosted jets with XCone

DOE PAGES

Thaler, Jesse; Wilkason, Thomas F.

2015-12-01

We show how the recently proposed XCone jet algorithm smoothly interpolates between resolved and boosted kinematics. When using standard jet algorithms to reconstruct the decays of hadronic resonances like top quarks and Higgs bosons, one typically needs separate analysis strategies to handle the resolved regime of well-separated jets and the boosted regime of fat jets with substructure. XCone, by contrast, is an exclusive cone jet algorithm that always returns a fixed number of jets, so jet regions remain resolved even when (sub)jets are overlapping in the boosted regime. In this paper, we perform three LHC case studies $-$ dijet resonances,more » Higgs decays to bottom quarks, and all-hadronic top pairs$-$ that demonstrate the physics applications of XCone over a wide kinematic range.« less

Simulations of Solar Jets

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-02-01

Formation of a coronal jet from twisted field lines that have reconnected with the ambient field. The colors show the radial velocity of the plasma. [Adapted from Szente et al. 2017]How do jets emitted from the Suns surface contribute to its corona and to the solar wind? In a recent study, a team of scientists performed complex three-dimensional simulations of coronal jets to answer these questions.Small ExplosionsCoronal jets are relatively small eruptions from the Suns surface, with heights of roughly 100 to 10,000 km, speeds of 10 to 1,000 km/s, and lifetimes of a few minutes to around ten hours. These jets are constantly present theyre emitted even from the quiet Sun, when activity is otherwise low and weve observed them with a fleet of Sun-watching space telescopes spanning the visible, extreme ultraviolet (EUV), and X-ray wavelength bands.A comparison of simulated observations based on the authors model (left panels) to actual EUV and X-ray observations of jets (right panels). [Szente et al. 2017]Due to their ubiquity, we speculate that these jets might contribute to heating the global solar corona (which is significantly hotter than the surface below it, a curiosity known as the coronal heating problem). We can also wonder what role these jets might play in driving the overall solar wind.Launching a JetLed by Judit Szente (University of Michigan), a team of scientists has explored the impact of coronal jets on the global corona and solar wind with a series of numerical simulations. Szente and collaborators used three-dimensional, magnetohydrodynamic simulations that provide realistic treatment of the solar atmosphere, the solar wind acceleration, and the complexities of heat transfer throughout the corona.In the authors simulations, a jet is initiated as a magnetic dipole rotates at the solar surface, winding up field lines. Magnetic reconnection between the twisted lines and the background field then launches the jet from the dense and hot solar

The Prospective Association Between Internalizing Symptoms and Adolescent Alcohol Involvement and the Moderating Role of Age and Externalizing Symptoms.

PubMed

Colder, Craig R; Shyhalla, Kathleen; Frndak, Seth; Read, Jennifer P; Lengua, Liliana J; Hawk, Larry W; Wieczorek, William F

2017-12-01

As predicted by self-medication theories that drinking is motivated by a desire to ameliorate emotional distress, some studies find internalizing symptoms (e.g., anxiety, depression) increase risk of adolescent drinking; however, such a risk effect has not been supported consistently. Our prior work examined externalizing symptoms as a potential moderator of the association between internalizing symptoms and adolescent alcohol use to explain some of the inconsistencies in the literature. We found that internalizing symptoms were protective against early adolescent alcohol use particularly for youth elevated on externalizing symptoms (a 2-way interaction). Our sample has now been followed for several additional assessments that extend into young adulthood, and the current study tests whether the protective effect of internalizing symptoms may change as youth age into young adulthood, and whether this age-moderating effect varied across different clusters of internalizing symptoms (social anxiety, generalized anxiety, and depression). Internalizing symptoms were hypothesized to shift from a protective factor to a risk factor with age, particularly for youth elevated on externalizing symptoms. A community sample of 387 adolescents was followed for 9 annual assessments (mean age = 12.1 years at the first assessment and 55% female). Multilevel cross-lagged 2-part zero-inflated Poisson models were used to test hypotheses. The most robust moderating effects were for levels of alcohol use, such that the protective effect of all internalizing symptom clusters was most evident in the context of moderate to high levels of externalizing problems. A risk effect of internalizing symptoms was evident at low levels of externalizing symptoms. With age, the risk and protective effects of internalizing symptoms were evident at less extreme levels of externalizing behavior. With respect to alcohol-related problems, findings did not support age moderation for generalized anxiety or

Airframe-Jet Engine Integration Noise

NASA Technical Reports Server (NTRS)

Tam, Christopher; Antcliff, Richard R. (Technical Monitor)

2003-01-01

It has been found experimentally that the noise radiated by a jet mounted under the wing of an aircraft exceeds that of the same jet in a stand-alone environment. The increase in noise is referred to as jet engine airframe integration noise. The objectives of the present investigation are, (1) To obtain a better understanding of the physical mechanisms responsible for jet engine airframe integration noise or installation noise. (2) To develop a prediction model for jet engine airframe integration noise. It is known that jet mixing noise consists of two principal components. They are the noise from the large turbulence structures of the jet flow and the noise from the fine scale turbulence. In this investigation, only the effect of jet engine airframe interaction on the fine scale turbulence noise of a jet is studied. The fine scale turbulence noise is the dominant noise component in the sideline direction. Thus we limit out consideration primarily to the sideline.

Analysis of Quasi-periodic Oscillations and Time Lag in Ultraluminous X-Ray Sources with XMM-Newton

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Zi-Jian; Xiao, Guang-Cheng; Zhang, Shu

We investigated the power density spectrum (PDS) and time lag of ultraluminous X-ray sources (ULXs) observed by XMM-Newton . We determined the PDSs for each ULX and found that five of them show intrinsic variability due to obvious quasi-periodic oscillations (QPOs) of mHz–1 Hz, consistent with previous reports. We further investigated these five ULXs to determine their possible time lag. The ULX QPOs exhibit a soft time lag that is linearly related to the QPO frequency. We discuss the likelihood of the ULX QPOs being type-C QPO analogs, and the time lag models. The ULXs might harbor intermediate-mass black holesmore » if their QPOs are type-C QPO analogs. We suggest that the soft lag and the linearity may be due to reverberation.« less

Assessing delay and lag in sagittal trunk control using a tracking task.

PubMed

Reeves, N Peter; Luis, Abraham; Chan, Elizabeth C; Sal Y Rosas, Victor G; Tanaka, Martin L

2018-05-17

Slower trunk muscle responses are linked to back pain and injury. Unfortunately, clinical assessments of spine function do not objectively evaluate this important attribute, which reflects speed of trunk control. Speed of trunk control can be parsed into two components: (1) delay, the time it takes to initiate a movement, and (2) lag, the time it takes to execute a movement once initiated. The goal of this study is to demonstrate a new approach to assess delay and lag in trunk control using a simple tracking task. Ten healthy subjects performed four blocks of six trials of trunk tracking in the sagittal plane. Delay and lag were estimated by modeling trunk control for predictable and unpredictable (control mode) trunk movements in flexion and extension (control direction) at movement amplitudes of 2°, 4°, and 6° (control amplitude). The main effect of control mode, direction, and amplitude of movement were compared between trial blocks to assess secondary influencers (e.g., fatigue). Only control mode was consistent across trial blocks with predictable movements being faster than unpredictable for both delay and lag. Control direction and amplitude effects on delay and lag were consistent across the first two trial blocks and less consistent in later blocks. Given the heterogeneity in the presentation of back pain, clinical assessment of trunk control should include different control modes, directions, and amplitudes. To reduce testing time and the influence of fatigue, we recommend six trials to assess trunk control. Copyright © 2018 Elsevier Ltd. All rights reserved.

Consequences of varied soil hydraulic and meteorological complexity on unsaturated zone time lag estimates.

PubMed

Vero, S E; Ibrahim, T G; Creamer, R E; Grant, J; Healy, M G; Henry, T; Kramers, G; Richards, K G; Fenton, O

2014-12-01

The true efficacy of a programme of agricultural mitigation measures within a catchment to improve water quality can be determined only after a certain hydrologic time lag period (subsequent to implementation) has elapsed. As the biophysical response to policy is not synchronous, accurate estimates of total time lag (unsaturated and saturated) become critical to manage the expectations of policy makers. The estimation of the vertical unsaturated zone component of time lag is vital as it indicates early trends (initial breakthrough), bulk (centre of mass) and total (Exit) travel times. Typically, estimation of time lag through the unsaturated zone is poor, due to the lack of site specific soil physical data, or by assuming saturated conditions. Numerical models (e.g. Hydrus 1D) enable estimates of time lag with varied levels of input data. The current study examines the consequences of varied soil hydraulic and meteorological complexity on unsaturated zone time lag estimates using simulated and actual soil profiles. Results indicated that: greater temporal resolution (from daily to hourly) of meteorological data was more critical as the saturated hydraulic conductivity of the soil decreased; high clay content soils failed to converge reflecting prevalence of lateral component as a contaminant pathway; elucidation of soil hydraulic properties was influenced by the complexity of soil physical data employed (textural menu, ROSETTA, full and partial soil water characteristic curves), which consequently affected time lag ranges; as the importance of the unsaturated zone increases with respect to total travel times the requirements for high complexity/resolution input data become greater. The methodology presented herein demonstrates that decisions made regarding input data and landscape position will have consequences for the estimated range of vertical travel times. Insufficiencies or inaccuracies regarding such input data can therefore mislead policy makers regarding

TRACING THE REVERBERATION LAG IN THE HARD STATE OF BLACK HOLE X-RAY BINARIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Marco, B.; Ponti, G.; Nandra, K.

2015-11-20

We report results obtained from a systematic analysis of X-ray lags in a sample of black hole X-ray binaries, with the aim of assessing the presence of reverberation lags and studying their evolution during outburst. We used XMM-Newton and simultaneous Rossi X-ray Timing Explorer (RXTE) observations to obtain broadband energy coverage of both the disk and the hard X-ray Comptonization components. In most cases the detection of reverberation lags is hampered by low levels of variability-power signal-to-noise ratio (typically when the source is in a soft state) and/or short exposure times. The most detailed study was possible for GX 339-4more » in the hard state, which allowed us to characterize the evolution of X-ray lags as a function of luminosity in a single source. Over all the sampled frequencies (∼0.05–9 Hz), we observe the hard lags intrinsic to the power-law component, already well known from previous RXTE studies. The XMM-Newton soft X-ray response allows us to detail the disk variability. At low frequencies (long timescales) the disk component always leads the power-law component. On the other hand, a soft reverberation lag (ascribable to thermal reprocessing) is always detected at high frequencies (short timescales). The intrinsic amplitude of the reverberation lag decreases as the source luminosity and the disk fraction increase. This suggests that the distance between the X-ray source and the region of the optically thick disk where reprocessing occurs gradually decreases as GX 339-4 rises in luminosity through the hard state, possibly as a consequence of reduced disk truncation.« less

Transactional relationships among cognitive vulnerabilities, stressors, and depressive symptoms in adolescence.

PubMed

Calvete, Esther; Orue, Izaskun; Hankin, Benjamin L

2013-04-01

The transactional cognitive vulnerability to stress model Hankin & Abramson (Psychological Bulletin, 127:773-796, 2001) extends the traditional diathesis-stress model by proposing that the relationships among cognitions, depressive symptoms, and stressors are dynamic and bidirectional. In this study three different pathways among these variables were assessed simultaneously: (1) cognitive vulnerabilities and stressors as predictors of depressive symptoms (vulnerability model), (2) depressive symptoms and cognitive vulnerabilities as predictors of stressors (stress generation model), and (3) depressive symptoms and stressors as predictors of cognitive vulnerabilities (consequence model). A fully cross-lagged design panel was employed with 1,187 adolescents (545 girls and 642 boys, Mean Age = 13.42 years) who were assessed at two time points separated by 6 months. They completed measures of cognitive vulnerabilities (maladaptive schema domains and negative inferential style), stressors, and depressive symptoms. Inferential style and schemas of the disconnection and rejection domain predicted prospective increases in depressive symptoms. Initial levels of depressive symptoms and most cognitive vulnerabilities predicted greater stress generation. Initial levels of stressors and depressive symptoms predicted an increase in negative inferential style and maladaptive schema domains over time. These bidirectional relationships were mostly similar for boys and girls, although there were a few gender differences. The findings support a transactional model with reciprocal relationships among stress, depressive symptoms, and cognitive vulnerabilities. Transactional implications for depression interventions among adolescents are discussed.

Development of a Jet Noise Prediction Method for Installed Jet Configurations

NASA Technical Reports Server (NTRS)

Hunter, Craig A.; Thomas, Russell H.

2003-01-01

This paper describes development of the Jet3D noise prediction method and its application to heated jets with complex three-dimensional flow fields and installation effects. Noise predictions were made for four separate flow bypass ratio five nozzle configurations tested in the NASA Langley Jet Noise Laboratory. These configurations consist of a round core and fan nozzle with and without pylon, and an eight chevron core nozzle and round fan nozzle with and without pylon. Predicted SPL data were in good agreement with experimental noise measurements up to 121 inlet angle, beyond which Jet3D under predicted low frequency levels. This is due to inherent limitations in the formulation of Lighthill's Acoustic Analogy used in Jet3D, and will be corrected in ongoing development. Jet3D did an excellent job predicting full scale EPNL for nonchevron configurations, and captured the effect of the pylon, correctly predicting a reduction in EPNL. EPNL predictions for chevron configurations were not in good agreement with measured data, likely due to the lower mixing and longer potential cores in the CFD simulations of these cases.

Phenomenology of single-inclusive jet production with jet radius and threshold resummation

NASA Astrophysics Data System (ADS)

Liu, Xiaohui; Moch, Sven-Olaf; Ringer, Felix

2018-03-01

We perform a detailed study of inclusive jet production cross sections at the LHC and compare the QCD theory predictions based on the recently developed formalism for threshold and jet radius joint resummation at next-to-leading logarithmic accuracy to inclusive jet data collected by the CMS Collaboration at √{S }=7 and 13 TeV. We compute the cross sections at next-to-leading order in QCD with and without the joint resummation for different choices of jet radii R and observe that the joint resummation leads to crucial improvements in the description of the data. Comprehensive studies with different parton distribution functions demonstrate the necessity of considering the joint resummation in fits of those functions based on the LHC jet data.

Accretion Disk Reverberation with Hubble Space Telescope Observations of NGC 4593: Evidence for Diffuse Continuum Lags

NASA Astrophysics Data System (ADS)

Cackett, Edward M.; Chiang, Chia-Ying; McHardy, Ian; Edelson, Rick; Goad, Michael R.; Horne, Keith; Korista, Kirk T.

2018-04-01

The Seyfert 1 galaxy NGC 4593 was monitored spectroscopically with the Hubble Space Telescope as part of a reverberation mapping campaign that also included Swift, Kepler, and ground-based photometric monitoring. During 2016 July 12–August 6, we obtained 26 spectra across a nearly continuous wavelength range of ∼1150–10000 Å. These were combined with Swift data to produce a UV/optical “lag spectrum,” which shows the interband lag relative to the Swift UVW2 band as a function of wavelength. The broad shape of the lag spectrum appears to follow the τ ∝ λ 4/3 relation seen previously in photometric interband lag measurements of other active galactic nuclei (AGNs). This shape is consistent with the standard thin disk model, but the magnitude of the lags implies a disk that is a factor of ∼3 larger than predicted, again consistent with what has been previously seen in other AGNs. In all cases these large disk sizes, which are also implied by independent gravitational microlensing of higher-mass AGNs, cannot be simply reconciled with the standard model. However, the most striking feature in this higher-resolution lag spectrum is a clear excess around the 3646 Å Balmer jump. This strongly suggests that diffuse emission from gas in the much larger broad-line region (BLR) must also contribute significantly to the interband lags. While the relative contributions of the disk and BLR cannot be uniquely determined in these initial measurements, it is clear that both will need to be considered to comprehensively model and understand AGN lag spectra.

Operation in the turbulent jet field of a linear array of multiple rectangular jets using a two-dimensional jet (Variation of mean velocity field)

NASA Astrophysics Data System (ADS)

Fujita, Shigetaka; Harima, Takashi

2016-03-01

The mean flowfield of a linear array of multiple rectangular jets run through transversely with a two-dimensional jet, has been investigated, experimentally. The object of this experiment is to operate both the velocity scale and the length scale of the multiple rectangular jets using a two-dimensional jet. The reason of the adoption of this nozzle exit shape was caused by the reports of authors in which the cruciform nozzle promoted the inward secondary flows strongly on both the two jet axes. Aspect ratio of the rectangular nozzle used in this experiment was 12.5. Reynolds number based on the nozzle width d and the exit mean velocity Ue (≅ 39 m / s) was kept constant 25000. Longitudinal mean velocity was measured using an X-array Hot-Wire Probe (lh = 3.1 μm in diameter, dh = 0.6 mm effective length : dh / lh = 194) operated by the linearized constant temperature anemometers (DANTEC), and the spanwise and the lateral mean velocities were measured using a yaw meter. The signals from the anemometers were passed through the low-pass filters and sampled using A.D. converter. The processing of the signals was made by a personal computer. Acquisition time of the signals was usually 60 seconds. From this experiment, it was revealed that the magnitude of the inward secondary flows on both the y and z axes in the upstream region of the present jet was promoted by a two-dimensional jet which run through transversely perpendicular to the multiple rectangular jets, therefore the potential core length on the x axis of the present jet extended 2.3 times longer than that of the multiple rectangular jets, and the half-velocity width on the rectangular jet axis of the present jet was suppressed 41% shorter compared with that of the multiple rectangular jets.

Does the benefit of testing depend on lag, and if so, why? Evaluating the elaborative retrieval hypothesis.

PubMed

Rawson, Katherine A; Vaughn, Kalif E; Carpenter, Shana K

2015-05-01

Despite the voluminous literatures on testing effects and lag effects, surprisingly few studies have examined whether testing and lag effects interact, and no prior research has directly investigated why this might be the case. To this end, in the present research we evaluated the elaborative retrieval hypothesis (ERH) as a possible explanation for why testing effects depend on lag. Elaborative retrieval involves the activation of cue-related information during the long-term memory search for the target. If the target is successfully retrieved, this additional information is encoded with the cue-target pair to yield a more elaborated memory trace that enhances target access on a later memory test. The ERH states that the degree of elaborative retrieval during practice is greater when testing takes place after a long rather than a short lag (whereas elaborative retrieval during restudy is minimal at either lag). Across two experiments, final-test performance was greater following practice testing than following restudy only, and this memorial advantage was greater with long-lag than with short-lag practice. The final test also included novel cue conditions used to diagnose the degree of elaborative retrieval during practice. The overall pattern of performance in these conditions provided consistent evidence for the ERH, with more extensive elaborative retrieval during long- than during short-lag practice testing.

CYTOGENETIC STUDIES IN MICE TREATED WITH THE JET FUELS, JET-A AND JP-8

EPA Science Inventory

Cytogenetic studies in mice treated with the jet fuels, Jet-A and JP-8
Abstract
The genotoxic potential of the jet fuels, Jet-A and JP-8, were examined in mice treated on the skin with a single dose of 240 ug/mouse. Peripheral blood smears were prepared at the start of the ...

Investigations of needle-free jet injections.

PubMed

Schramm-Baxter, J R; Mitragotri, S

2004-01-01

Jet injection is a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers drugs. Although a number of jet injectors are commercially available, especially for insulin delivery, they have a low market share compared to needles possibly due to occasional pain associated with jet injection. Jets employed by the traditional jet injectors penetrate deep into the dermal and sub-dermal regions where the nerve endings are abundantly located. To eliminate the pain associated with jet injections, we propose to utilize microjets that penetrate only into the superficial region of the skin. However, the choice of appropriate jet parameters for this purpose is challenging owing to the multiplicity of factors that determine the penetration depth. Here, we describe the dependence of jet injections into human skin on the power of the jet. Dermal delivery of liquid jets was quantified using two measurements, penetration of a radiolabeled solute, mannitol, into skin and the shape of jet dispersion in the skin which was visualized using sulforhodamine B. The dependence of the amount of liquid delivered in the skin and the geometric measurements of jet dispersion on nozzle diameter and jet velocity was captured by a single parameter, jet power.

Function and regulation of LAG3 on CD4+CD25- T cells in non-small cell lung cancer.

PubMed

Ma, Qin-Yun; Huang, Da-Yu; Zhang, Hui-Jun; Wang, Shaohua; Chen, Xiao-Feng

2017-11-15

LAG3 is a surface molecule found on a subset of immune cells. The precise function of LAG3 appears to be context-dependent. In this study, we investigated the effect of LAG3 on CD4 + CD25 - T cells from non-small cell lung cancer (NSCLC) patients. We found that in the peripheral blood mononuclear cells of NSCLC patients, LAG3 was significantly increased in CD4 + T cells directly ex vivo and primarily in the CD4 + CD25 - fraction, which was regulated by prolonged TCR stimulation and the presence of IL-27. TCR stimulation also increased CD25 expression, but not Foxp3 expression, in LAG3-expressing CD4 + CD25 - cells Compared to LAG3-nonexpressing CD4 + CD25 - cells, LAG3-expressing CD4 + CD25 - cells presented significantly higher levels of PD1 and TIM3, two inhibitory receptors best described in exhausted CD8 + T effector cells. LAG3-expressing CD4 + CD25 - cells also presented impaired proliferation compared with LAG3-nonexpressing CD4 + CD25 - cells but could be partially rescued by inhibiting both PD1 and TIM3. Interestingly, CD8 + T cells co-incubated with LAG3-expressing CD4 + CD25 - cells at equal cell numbers demonstrated significantly lower proliferation than CD8 + T cells incubated alone. Co-culture with CD8 + T cell and LAG3-expressing CD4 + CD25 - T cell also upregulated soluble IL-10 level in the supernatant, of which the concentration was positively correlated with the number of LAG3-expressing CD4 + CD25 - T cells. In addition, we found that LAG3-expressing CD4 + CD25 - T cells infiltrated the resected tumors and were present at higher frequencies of in metastases than in primary tumors. Taken together, these data suggest that LAG3-expressing CD4 + CD25 - T cells represent another regulatory immune cell type with potential to interfere with anti-tumor immunity. Copyright © 2017 Elsevier Inc. All rights reserved.

The influence of interactions between accommodation and convergence on the lag of accommodation.

PubMed

Schor, C

1999-03-01

Several models of myopia predict that growth of axial length is stimulated by blur. Accommodative lag has been suggested as an important source of blur in the development of myopia and this study has modeled how cross-link interactions between accommodation and convergence might interact with uncorrected distance heterophoria and refractive error to influence accommodative lag. Accommodative lag was simulated with two models of interactions between accommodation and convergence (one with and one without adaptable tonic elements). Simulations of both models indicate that both uncorrected hyperopia and esophoria increase the lag of accommodative and uncorrected myopia and exophoria decrease the lag or introduce a lead of accommodation in response to the near (40 cm) stimulus. These effects were increased when gain of either cross-link, accommodative convergence (AC/A) or convergence accommodation (CA/C), was increased within a moderate range of values while the other was fixed at a normal value (clamped condition). These effects were exaggerated when both the AC/A and CA/C ratios were increased (covaried condition) and affects of cross-link gain were negated when an increase of one cross-link (e.g. AC/A) was accompanied by a reduction of the other cross-link (e.g. CA/C) (reciprocal condition). The inclusion of tonic adaptation in the model reduced steady state errors of accommodation for all conditions except when the AC/A ratio was very high (2 MA/D). Combinations of cross-link interactions between accommodation and convergence that resemble either clamped or reciprocal patterns occur naturally in clinical populations. Simulations suggest that these two patterns of abnormal cross-link interactions could affect the progression of myopia differently. Adaptable tonic accommodation and tonic vergence could potentially reduce the progression of myopia by reducing the lag of accommodation.

Increasing Vocal Variability in Children with Autism Using a Lag Schedule of Reinforcement

ERIC Educational Resources Information Center

Esch, John W.; Esch, Barbara E.; Love, Jessa R.

2009-01-01

Variability has been demonstrated to be an operant dimension of behavior (Neuringer, 2002; Page & Neuringer, 1985). Recently, lag schedules have been used to demonstrate operant variability of verbal behavior in persons with a diagnosis of autism (e.g., Lee, McComas, & Jawor, 2002). The current study evaluated the effects of a Lag 1 schedule on…

Estimation of watershed lag times and times of concentration for the Kansas City Area.

DOT National Transportation Integrated Search

2016-04-01

Lag time (TL) and time of concentration (TC) are two related measures of how quickly a stream responds to : runoff-producing rainfall over its watershed. In this report, a general relationship for lag time is derived from the : Manning equation for f...

Eating Disorder Symptomatology and Identity Formation in Adolescence: A Cross-Lagged Longitudinal Approach.

PubMed

Verschueren, Margaux; Claes, Laurence; Bogaerts, Annabel; Palmeroni, Nina; Gandhi, Amarendra; Moons, Philip; Luyckx, Koen

2018-01-01

Introduction: Eating disorder symptomatology, comprising both psychological and behavioral aspects of subclinical eating concerns, constitutes a clear precursor of developing eating disorders. It is crucial to investigate its antecedents and correlates to subsequently inform eating disorder prevention programs. The present study focused on identity formation, a core developmental task in adolescence, that has increasingly been linked to eating disorder development. Our main aim was to examine the temporal sequence between eating disorder symptomatology and identity formation. Methods: Data on eating disorder symptomatology and identity formation were collected in 530 high school students (at Time 1: mean age = 15 years; SD = 1.84; range: 12-18 years; 50.6% females) using self-report questionnaires at three annual measurement points. Cross-lagged structural equation modeling was performed to examine the directionality of effects. Results: Results indicated bidirectional effects between eating disorder symptomatology and identity formation. Identity confusion seemed to increase vulnerability to body dissatisfaction and bulimia symptoms, whereas identity synthesis seemed to protect against their development. Additionally, identity synthesis seemed to protect against the development of drive for thinness as well. At the same time, body dissatisfaction and bulimia symptoms positively predicted identity confusion and negatively predicted identity synthesis over time. Conclusion: The present study adds to the growing body of literature on identity and eating disorders by focusing on their temporal interplay in a community sample of adolescents. As bidirectional effects emerged, a greater emphasis on identity formation in eating disorder prevention programs is advocated.

Eating Disorder Symptomatology and Identity Formation in Adolescence: A Cross-Lagged Longitudinal Approach

PubMed Central

Verschueren, Margaux; Claes, Laurence; Bogaerts, Annabel; Palmeroni, Nina; Gandhi, Amarendra; Moons, Philip; Luyckx, Koen

2018-01-01

Introduction: Eating disorder symptomatology, comprising both psychological and behavioral aspects of subclinical eating concerns, constitutes a clear precursor of developing eating disorders. It is crucial to investigate its antecedents and correlates to subsequently inform eating disorder prevention programs. The present study focused on identity formation, a core developmental task in adolescence, that has increasingly been linked to eating disorder development. Our main aim was to examine the temporal sequence between eating disorder symptomatology and identity formation. Methods: Data on eating disorder symptomatology and identity formation were collected in 530 high school students (at Time 1: mean age = 15 years; SD = 1.84; range: 12–18 years; 50.6% females) using self-report questionnaires at three annual measurement points. Cross-lagged structural equation modeling was performed to examine the directionality of effects. Results: Results indicated bidirectional effects between eating disorder symptomatology and identity formation. Identity confusion seemed to increase vulnerability to body dissatisfaction and bulimia symptoms, whereas identity synthesis seemed to protect against their development. Additionally, identity synthesis seemed to protect against the development of drive for thinness as well. At the same time, body dissatisfaction and bulimia symptoms positively predicted identity confusion and negatively predicted identity synthesis over time. Conclusion: The present study adds to the growing body of literature on identity and eating disorders by focusing on their temporal interplay in a community sample of adolescents. As bidirectional effects emerged, a greater emphasis on identity formation in eating disorder prevention programs is advocated. PMID:29915548

Jetting Through the Primordial Universe

NASA Astrophysics Data System (ADS)

Kunnawalkam Elayavalli, Raghav

Collisions of heavy ion nuclei at relativistic speeds (close to the speed of light), sometimes referred to as the "little bang", can recreate conditions similar to the early universe. This high temperature and very dense form of matter, now known to consist of de-confined quarks and gluons is named the quark gluon plasma (QGP). An early signature of the QGP, both theorized and seen in experiments, was the aspect of "jet quenching" and understanding that phenomenon will be the main focus of this thesis. The concept behind quenching is that a high energetic quark or gluon jet undergoes significant energy loss due to the overall structure modifications related to its fragmentation and radiation patterns as it traverses the medium. The term jet, parameterized by a fixed lateral size or the jet radius, represents the collimated spray of particles arising from an initial parton. In this thesis, Run1 experimental data from pp and heavy ion collisions at the CERN LHC is analyzed with the CMS detector. Analysis steps involved in the measurement of the inclusive jet cross section in pp, pPb and PbPb systems are outlined in detail. The pp jet cross section is compared with next to leading order theoretical calculations supplemented with non perturbative corrections for three different jet radii highlighting better comparisons for larger radii jets. Measurement of the jet yield followed by the nuclear modification factors in proton-lead at 5.02 TeV and lead-lead collisions at 2.76 TeV are presented. Since pp data at 5.02 TeV was not available in Run1, an extrapolation method is performed to derive a reference pp spectra. A new data driven technique is introduced to estimate and correct for the fake jet contribution in PbPb for low transverse momenta jets. The nuclear modification factors studied in this thesis show jet quenching to be attributed to final state effects, have a strong correlation to the event centrality, a weak inverse correlation to the jet transverse momenta

Simultaneous measurements of ozone outside and inside cabins of two B-747 airliners and a Gates Learjet business jet

NASA Technical Reports Server (NTRS)

Perkins, P. J.; Briehl, D.

1978-01-01

Recently, passengers and crew members on long-distance commercial flights have filed complaints after suffering symptoms of ozone sickness. Studies were conducted to determine the frequency and concentration of ozone in commercial jet transports. The airliner problem with ozone prompted NASA to determine the ozone concentrations that might be encountered in the cabin of a small business jet. Simultaneous measurements of atmospheric ozone levels and ozone levels in the cabins of jet aircraft were necessary because of the wide and rapid variability of atmospheric ozone in flight. It was found that the atmospheric ozone concentrations in the case of B-747 airliners vary widely during a flight. A constant difference, or ratio, between ozone concentrations outside and inside the cabin does not exist.

A comparison of alternative variants of the lead and lag time TTO.

PubMed

Devlin, Nancy; Buckingham, Ken; Shah, Koonal; Tsuchiya, Aki; Tilling, Carl; Wilkinson, Grahame; van Hout, Ben

2013-05-01

'Lead Time' TTO improves upon conventional TTO by providing a uniform method for eliciting positive and negative values. This research investigates (i) the values generated from different combinations of time in poor health and in full health; and the order in which these appear (lead vs. lag); (ii) whether values concur with participants' views about states; (iii) methods for handling extreme preferences. n = 208 participants valued five EQ-5D states, using two of four variants. Combinations of lead time and health state duration were: 10 years and 20 years; 5 years and 1 year; 5 years and 10 years; and a health state duration of 5 years with a lag time of 10 years. Longer lead times capture more preferences, but may involve a framing effect. Lag time results in less non-trading for mild states, and less time being traded for severe states. Negative values broadly agree with participants' stated opinion that the state is worse than dead. The values are sensitive to the ratio of lead time to duration of poor health, and the order in which these appear (lead vs. lag). It is feasible to handle extreme preferences though challenges remain. Copyright © 2012 John Wiley & Sons, Ltd.

Temporal Associations Among Chronic PTSD Symptoms in U.S. Combat Veterans.

PubMed

Doron-LaMarca, Susan; Niles, Barbara L; King, Daniel W; King, Lynda A; Pless Kaiser, Anica; Lyons, Michael J

2015-10-01

The present study examined fluctuation over time in symptoms of posttraumatic stress disorder (PTSD) among 34 combat veterans (28 with diagnosed PTSD, 6 with subclinical symptoms) assessed every 2 weeks for up to 2 years (range of assessments = 13-52). Temporal relationships were examined among four PTSD symptom clusters (reexperiencing, avoidance, emotional numbing, and hyperarousal) with particular attention to the influence of hyperarousal. Multilevel cross-lagged random coefficients autoregression for intensive time series data analyses were used to model symptom fluctuation decades after combat experiences. As anticipated, hyperarousal predicted subsequent fluctuations in the 3 other PTSD symptom clusters (reexperiencing, avoidance, emotional numbing) at subsequent 2-week intervals (rs = .45, .36, and .40, respectively). Additionally, emotional numbing influenced later reexperiencing and avoidance, and reexperiencing influenced later hyperarousal (rs = .44, .40, and .34, respectively). These findings underscore the important influence of hyperarousal. Furthermore, results indicate a bidirectional relationship between hyperarousal and reexperiencing as well as a possible chaining of symptoms (hyperarousal → emotional numbing → reexperiencing → hyperarousal) and establish potential internal, intrapersonal mechanisms for the maintenance of persistent PTSD symptoms. Results suggested that clinical interventions targeting hyperarousal and emotional numbing symptoms may hold promise for PTSD of long duration. Published 2015. This article is a US Government work and is in the public domain in the USA. View this article online at wileyonlinelibrary.com.

Characteristics and generation of secondary jets and secondary gigantic jets

NASA Astrophysics Data System (ADS)

Lee, Li-Jou; Huang, Sung-Ming; Chou, Jung-Kung; Kuo, Cheng-Ling; Chen, Alfred B.; Su, Han-Tzong; Hsu, Rue-Rou; Frey, Harald U.; Takahashi, Yukihiro; Lee, Lou-Chuang

2012-06-01

Secondary transient luminous events (TLEs) recorded by the ISUAL-FORMOSAT2 mission can either be secondary jets or secondary gigantic jets (GJs), depending on their terminal altitudes. The secondary jets emerge from the cloud top beneath the preceding sprites and extend upward to the base of the sprites at ˜50 km. The secondary jets likely are negative electric discharges with vertically straight luminous columns, morphologically resembling the trailing jet of the type-I GJs. The number of luminous columns in a secondary jet seems to be affected by the size of the effective capacitor plate formed near the base of the preceding sprites and the charge distribution left behind by the sprite-inducing positive cloud-to-ground discharges. The secondary GJs originate from the cloud top under the shielding area of the preceding sprites, and develop upward to reach the lower ionosphere at ˜90 km. The observed morphology of the secondary GJs can either be the curvy shifted secondary GJs extending outside the region occupied by the preceding sprites or the straight pop-through secondary GJs developing through the center of the preceding circular sprites. A key factor in determining the terminal height of the secondary TLEs appears to be the local ionosphere boundary height that established by the preceding sprites. The abundance and the distribution of the negative charge in the thundercloud following the sprite-inducing positive cloud-to-ground discharges may play important role in the generation of the secondary TLEs.

Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability.

PubMed

Maddox, Brenna B; Cleary, Patrick; Kuschner, Emily S; Miller, Judith S; Armour, Anna Chelsea; Guy, Lisa; Kenworthy, Lauren; Schultz, Robert T; Yerys, Benjamin E

2017-08-01

Many children with autism spectrum disorder display challenging behaviors. These behaviors are not limited to those with cognitive and/or language impairments. The Collaborative and Proactive Solutions framework proposes that challenging behaviors result from an incompatibility between environmental demands and a child's "lagging skills." The primary Collaborative and Proactive Solutions lagging skills-executive function, emotion regulation, language, and social skills-are often areas of weakness for individuals with autism spectrum disorder. The purpose of this study was to evaluate whether these lagging skills are associated with challenging behaviors in youth with autism spectrum disorder without intellectual disability. Parents of 182 youth with autism spectrum disorder (6-15 years) completed measures of their children's challenging behaviors, executive function, language, emotion regulation, and social skills. We tested whether the Collaborative and Proactive Solutions lagging skills predicted challenging behaviors using multiple linear regression. The Collaborative and Proactive Solutions lagging skills explained significant variance in participants' challenging behaviors. The Depression (emotion regulation), Inhibit (executive function), and Sameness (executive function) scales emerged as significant predictors. Impairments in emotion regulation and executive function may contribute substantially to aggressive and oppositional behaviors in school-age youth with autism spectrum disorder without intellectual disability. Treatment for challenging behaviors in this group may consider targeting the incompatibility between environmental demands and a child's lagging skills.

Current Status of Biomedical Book Reviewing: Part II. Time Lag in Biomedical Book Reviewing

PubMed Central

Chen, Ching-Chih

1974-01-01

This part of the study explores the effectiveness of the review media in terms of speed of reviewing, comprehensiveness of review treatment, and authority. The time lags for the fifty-four journals varied widely, the mean ranging from 5.8 months to forty-two months. The time lags for all 3,347 reviews varied even more widely, ranging from less than a month to 108 months after a book was off the press. The 3,347 reviews had a mean time lag of 10.43 months and a standard deviation of 6.63 months. PMID:4826480

VISCOUS BOUNDARY LAYERS OF RADIATION-DOMINATED, RELATIVISTIC JETS. II. THE FREE-STREAMING JET MODEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coughlin, Eric R.; Begelman, Mitchell C., E-mail: eric.coughlin@colorado.edu, E-mail: mitch@jila.colorado.edu

2015-08-10

We analyze the interaction of a radiation-dominated jet and its surroundings using the equations of radiation hydrodynamics in the viscous limit. In a previous paper we considered the two-stream scenario, which treats the jet and its surroundings as distinct media interacting through radiation viscous forces. Here we present an alternative boundary layer model, known as the free-streaming jet model—where a narrow stream of fluid is injected into a static medium—and present solutions where the flow is ultrarelativistic and the boundary layer is dominated by radiation. It is shown that these jets entrain material from their surroundings and that their coresmore » have a lower density of scatterers and a harder spectrum of photons, leading to observational consequences for lines of sight that look “down the barrel of the jet.” These jetted outflow models may be applicable to the jets produced during long gamma-ray bursts and super-Eddington phases of tidal disruption events.« less

Racial/ethnic discrimination, posttraumatic stress symptoms, and alcohol problems in a longitudinal study of Hispanic/Latino college students.

PubMed

Cheng, Hsiu-Lan; Mallinckrodt, Brent

2015-01-01

Racial/ethnic discrimination has been identified as a risk factor in the development of posttraumatic stress disorder (PTSD) symptoms in persons of color (Carter, 2007). Many persons, regardless of race/ethnicity, with PTSD symptoms resulting from combat, violent crimes, sexual assault, or natural disasters use alcohol in an attempt to cope. This longitudinal study surveyed 203 Hispanic/Latino students twice at approximately a 1-year interval, and used a cross-lagged design to compare Time 1 links from alcohol use and experiences of discrimination with the same variables at Time 2, plus symptoms of PTSD. Each survey included the General Ethnic Discrimination scale and the Alcohol Use Disorders Identification Test. Only Time 2 packets contained the Posttraumatic Stress Disorder Checklist-Civilian. Cross-lagged analyses conducted by comparing nested structural equation models found that fixing the causal paths to zero from Time 1 experiences of discrimination to Time 2 alcohol problems and PTSD resulted in a significantly worse fit of the data. However, fixing the paths to zero from Time 1 maladaptive alcohol use to Time 2 PTSD and experiences of discrimination resulted in no significant difference in model fit. Thus, this pattern of findings is consistent with an inference that Hispanic/Latino college students who experience racial/ethnic discrimination are at risk for developing symptoms of posttraumatic stress and increased maladaptive alcohol use; conversely, maladaptive alcohol use does not appear to be a risk factor for later experiences of discrimination or PTSD symptoms. PsycINFO Database Record (c) 2015 APA, all rights reserved.

Radio Emission from Three-dimensional Relativistic Hydrodynamic Jets: Observational Evidence of Jet Stratification

NASA Astrophysics Data System (ADS)

Aloy, Miguel-Angel; Gómez, José-Luis; Ibáñez, José-María; Martí, José-María; Müller, Ewald

2000-01-01

We present the first radio emission simulations from high-resolution three-dimensional relativistic hydrodynamic jets; these simulations allow us to study the observational implications of the interaction between the jet and the external medium. This interaction gives rise to a stratification of the jet in which a fast spine is surrounded by a slow high-energy shear layer. The stratification (in particular, the large specific internal energy and slow flow in the shear layer) largely determines the emission from the jet. If the magnetic field in the shear layer becomes helical (e.g., resulting from an initial toroidal field and an aligned field component generated by shear), the emission shows a cross section asymmetry, in which either the top or the bottom of the jet dominates the emission. This, as well as limb or spine brightening, is a function of the viewing angle and flow velocity, and the top/bottom jet emission predominance can be reversed if the jet changes direction with respect to the observer or if it presents a change in velocity. The asymmetry is more prominent in the polarized flux because of field cancellation (or amplification) along the line of sight. Recent observations of jet cross section emission asymmetries in the blazar 1055+018 can be explained by assuming the existence of a shear layer with a helical magnetic field.

Lag threads organize the brain’s intrinsic activity

PubMed Central

Mitra, Anish; Snyder, Abraham Z.; Blazey, Tyler; Raichle, Marcus E.

2015-01-01

It has been widely reported that intrinsic brain activity, in a variety of animals including humans, is spatiotemporally structured. Specifically, propagated slow activity has been repeatedly demonstrated in animals. In human resting-state fMRI, spontaneous activity has been understood predominantly in terms of zero-lag temporal synchrony within widely distributed functional systems (resting-state networks). Here, we use resting-state fMRI from 1,376 normal, young adults to demonstrate that multiple, highly reproducible, temporal sequences of propagated activity, which we term “lag threads,” are present in the brain. Moreover, this propagated activity is largely unidirectional within conventionally understood resting-state networks. Modeling experiments show that resting-state networks naturally emerge as a consequence of shared patterns of propagation. An implication of these results is that common physiologic mechanisms may underlie spontaneous activity as imaged with fMRI in humans and slowly propagated activity as studied in animals. PMID:25825720

DNA-directed mutations. Leading and lagging strand specificity

NASA Technical Reports Server (NTRS)

Sinden, R. R.; Hashem, V. I.; Rosche, W. A.

1999-01-01

The fidelity of replication has evolved to reproduce B-form DNA accurately, while allowing a low frequency of mutation. The fidelity of replication can be compromised, however, by defined order sequence DNA (dosDNA) that can adopt unusual or non B-DNA conformations. These alternative DNA conformations, including hairpins, cruciforms, triplex DNAs, and slipped-strand structures, may affect enzyme-template interactions that potentially lead to mutations. To analyze the effect of dosDNA elements on spontaneous mutagenesis, various mutational inserts containing inverted repeats or direct repeats were cloned in a plasmid containing a unidirectional origin of replication and a selectable marker for the mutation. This system allows for analysis of mutational events that are specific for the leading or lagging strands during DNA replication in Escherichia coli. Deletions between direct repeats, involving misalignment stabilized by DNA secondary structure, occurred preferentially on the lagging strand. Intermolecular strand switch events, correcting quasipalindromes to perfect inverted repeats, occurred preferentially during replication of the leading strand.

Perspectives on jet noise

NASA Technical Reports Server (NTRS)

Ribner, H. S.

1981-01-01

Jet noise is a byproduct of turbulence. Until recently turbulence was assumed to be known statistically, and jet noise was computed therefrom. As a result of new findings though on the behavior of vortices and instability waves, a more integrated view of the problem has been accepted lately. After presenting a simple view of jet noise, the paper attempts to resolve the apparent differences between Lighthill's and Lilley's interpretations of mean-flow shear, and examines a number of ad hoc approaches to jet noise suppression.

Reverse Flood Routing with the Lag-and-Route Storage Model

NASA Astrophysics Data System (ADS)

Mazi, K.; Koussis, A. D.

2010-09-01

This work presents a method for reverse routing of flood waves in open channels, which is an inverse problem of the signal identification type. Inflow determination from outflow measurements is useful in hydrologic forensics and in optimal reservoir control, but has been seldom studied. Such problems are ill posed and their solution is sensitive to small perturbations present in the data, or to any related uncertainty. Therefore the major difficulty in solving this inverse problem consists in controlling the amplification of errors that inevitably befall flow measurements, from which the inflow signal is to be determined. The lag-and-route model offers a convenient framework for reverse routing, because not only is formal deconvolution not required, but also reverse routing is through a single linear reservoir. In addition, this inversion degenerates to calculating the intermediate inflow (prior to the lag step) simply as the sum of the outflow and of its time derivative multiplied by the reservoir’s time constant. The remaining time shifting (lag) of the intermediate, reversed flow presents no complications, as pure translation causes no error amplification. Note that reverse routing with the inverted Muskingum scheme (Koussis et al., submitted to the 12th Plinius Conference) fails when that scheme is specialised to the Kalinin-Miljukov model (linear reservoirs in series). The principal functioning of the reverse routing procedure was verified first with perfect field data (outflow hydrograph generated by forward routing of a known inflow hydrograph). The field data were then seeded with random error. To smooth the oscillations caused by the imperfect (measured) outflow data, we applied a multipoint Savitzky-Golay low-pass filter. The combination of reverse routing and filtering achieved an effective recovery of the inflow signal extremely efficiently. Specifically, we compared the reverse routing results of the inverted lag-and-route model and of the inverted

A strong radio brightening at the jet base of M 87 during the elevated very high energy gamma-ray state in 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hada, K.; Giroletti, M.; Giovannini, G.

2014-06-20

We report our intensive, high angular resolution radio monitoring observations of the jet in M 87 with the VLBI Exploration of Radio Astrometry (VERA) and the European VLBI Network (EVN) from 2011 February to 2012 October, together with contemporaneous high-energy (100 MeV 100 GeV) γ rays by VERITAS. We detected a remarkable (up to ∼70%) increase of the radio flux density from the unresolved jet base (radio core) with VERA at 22 and 43 GHz coincident with the VHE activity. Meanwhile, we confirmed with EVN at 5 GHz that the peculiar knot, HST-1, which is an alternative favored γ-ray productionmore » site located at ≳120 pc from the nucleus, remained quiescent in terms of its flux density and structure. These results in the radio bands strongly suggest that the VHE γ-ray activity in 2012 originates in the jet base within 0.03 pc or 56 Schwarzschild radii (the VERA spatial resolution of 0.4 mas at 43 GHz) from the central supermassive black hole. We further conducted VERA astrometry for the M 87 core at six epochs during the flaring period, and detected core shifts between 22 and 43 GHz, a mean value of which is similar to that measured in the previous astrometric measurements. We also discovered a clear frequency-dependent evolution of the radio core flare at 43, 22, and 5 GHz; the radio flux density increased more rapidly at higher frequencies with a larger amplitude, and the light curves clearly showed a time-lag between the peaks at 22 and 43 GHz, the value of which is constrained to be within ∼35-124 days. This indicates that a new radio-emitting component was created near the black hole in the period of the VHE event, and then propagated outward with progressively decreasing synchrotron opacity. By combining the obtained core shift and time-lag, we estimated an apparent speed of the newborn component propagating through the opaque region between the cores at 22 and 43 GHz. We derived a sub-luminal speed (less than ∼0.2c) for this component. This

A Daily Diary Study of Posttraumatic Stress Symptoms and Romantic Partner Accommodation

PubMed Central

Campbell, Sarah B.; Renshaw, Keith D.; Kashdan, Todd B.; Curby, Timothy W.; Carter, Sarah P.

2017-01-01

Little is known about the role of romantic partner symptom accommodation in PTSD symptom maintenance. To explore the bidirectional associations of posttraumatic stress disorder (PTSD) symptoms and romantic partner symptom accommodation over time, military servicemen (n = 64) with symptoms of PTSD and their co-habiting heterosexual civilian romantic partners (n = 64) completed a 2-week daily diary study. Cross-lagged, autoregressive models assessed the stability of men’s PTSD symptoms and partners’ accommodation, as well as the prospective associations of earlier PTSD symptoms with later accommodation and vice versa. Analyses used Bayesian estimation to provide point estimates (b) and Credible Intervals (CIs). In all models, PTSD symptoms (total and individual clusters) were highly stable (b = 0.91; CI: 0.88–0.95), and accommodation was moderately stable (b = 0.48; CI: 0.40–0.54). In all models, earlier PTSD symptoms (total and clusters) were significantly, positively associated with later accommodation (b = 0.04; CI: 0.02–0.07). In contrast, earlier accommodation was significantly associated only with later situational avoidance (b = 0.02; CI: 0.00–0.07). Thus, PTSD symptoms may lead to subsequent accommodating behaviors in romantic partners, but partner accommodation seems to contribute only to survivors’ future situational avoidance symptoms. The findings reinforce the notion that PTSD symptoms have an impact on relationship behaviors, and that accommodation from partners may sustain avoidant behaviors in particular. Clinicians should attend to romantic partners’ accommodating behaviors when working with survivors. PMID:28270332

Interaction of 5-HTTLPR and Idiographic Stressors Predicts Prospective Depressive Symptoms Specifically among Youth in a Multiwave Design

ERIC Educational Resources Information Center

Hankin, Benjamin L.; Jenness, Jessica; Abela, John R. Z.; Smolen, Andrew

2011-01-01

5-HTTLPR, episodic stressors, depressive and anxious symptoms were assessed prospectively (child and parent report) every 3 months over 1 year (5 waves of data) among community youth ages 9 to 15 (n = 220). Lagged hierarchical linear modeling analyses showed 5-HTTLPR interacted with idiographic stressors (increases relative to the child's own…

Diverse Responses of Global Vegetation to Climate Changes: Spatial Patterns and Time-lag Effects

NASA Astrophysics Data System (ADS)

Wu, D.; Zhao, X.; Zhou, T.; Huang, K.; Xu, W.

2014-12-01

Global climate changes have enormous influences on vegetation growth, meanwhile, response of vegetation to climate express space diversity and time-lag effects, which account for spatial-temporal disparities of climate change and spatial heterogeneity of ecosystem. Revelation of this phenomenon will help us further understanding the impact of climate change on vegetation. Assessment and forecast of global environmental change can be also improved under further climate change. Here we present space diversity and time-lag effects patterns of global vegetation respond to three climate factors (temperature, precipitation and solar radiation) based on quantitative analysis of satellite data (NDVI) and Climate data (Climate Research Unit). We assessed the time-lag effects of global vegetation to main climate factors based on the great correlation fitness between NDVI and the three climate factors respectively among 0-12 months' temporal lags. On this basis, integrated response model of NDVI and the three climate factors was built to analyze contribution of different climate factors to vegetation growth with multiple regression model and partial correlation model. In the result, different vegetation types have distinct temporal lags to the three climate factors. For the precipitation, temporal lags of grasslands are the shortest while the evergreen broad-leaf forests are the longest, which means that grasslands are more sensitive to precipitation than evergreen broad-leaf forests. Analysis of different climate factors' contribution to vegetation reveal that vegetation are dominated by temperature in the high northern latitudes; they are mainly restricted by precipitation in arid and semi-arid areas (Australia, Western America); in humid areas of low and intermediate latitudes (Amazon, Eastern America), vegetation are mainly influenced by solar radiation. Our results reveal the time-lag effects and major driving factors of global vegetation growth and explain the

Transport and time lag of chlorofluorocarbon gases in the unsaturated zone, Rabis Creek, Denmark

USGS Publications Warehouse

Engesgaard, Peter; Højberg, Anker L.; Hinsby, Klaus; Jensen, Karsten H.; Laier, Troels; Larsen, Flemming; Busenberg, Eurybiades; Plummer, Niel

2004-01-01

Transport of chlorofluorocarbon (CFC) gases through the unsaturated zone to the water table is affected by gas diffusion, air–water exchange (solubility), sorption to the soil matrix, advective–dispersive transport in the water phase, and, in some cases, anaerobic degradation. In deep unsaturated zones, this may lead to a time lag between entry of gases at the land surface and recharge to groundwater. Data from a Danish field site were used to investigate how time lag is affected by variations in water content and to explore the use of simple analytical solutions to calculate time lag. Numerical simulations demonstrate that either degradation or sorption of CFC-11 takes place, whereas CFC-12 and CFC-113 are nonreactive. Water flow did not appreciably affect transport. An analytical solution for the period with a linear increase in atmospheric CFC concentrations (approximately early 1970s to early 1990s) was used to calculate CFC profiles and time lags. We compared the analytical results with numerical simulations. The time lags in the 15-m-deep unsaturated zone increase from 4.2 to between 5.2 and 6.1 yr and from 3.4 to 3.9 yr for CFC-11 and CFC-12, respectively, when simulations change from use of an exponential to a linear increase in atmospheric concentrations. The CFC concentrations at the water table before the early 1990s can be estimated by displacing the atmospheric input function by these fixed time lags. A sensitivity study demonstrates conditions under which a time lag in the unsaturated zone becomes important. The most critical parameter is the tortuosity coefficient. The analytical approach is valid for the low range of tortuosity coefficients (τ = 0.1–0.4) and unsaturated zones greater than approximately 20 m in thickness. In these cases the CFC distribution may still be from either the exponential or linear phase. In other cases, the use of numerical models, as described in our work and elsewhere, is an option.

Hydraulic fluids and jet engine oil: pyrolysis and aircraft air quality.

PubMed

van Netten, C; Leung, V

2001-01-01

Incidents of smoke in aircraft cabins often result from jet engine oil and/or hydraulic fluid that leaks into ventilation air, which can be subjected to temperatures that exceed 500 degrees C. Exposed flight-crew members have reported symptoms, including dizziness, nausea, disorientation, blurred vision, and tingling in the legs and arms. In this study, the authors investigated pyrolysis products of one jet engine oil and two hydraulic fluids at 525 degrees C. Engine oil was an important source of carbon monoxide. Volatile agents and organophosphate constituents were released from all the agents tested; however, the neurotoxin trimethyl propane phosphate was not found. The authors hypothesized that localized condensation of pyrolysis products in ventilation ducts, followed by mobilization when cabin heat demand was high, accounted for mid-flight incidents. The authors recommended that carbon monoxide data be logged continuously to capture levels during future incidents.

The Dark Side of Internet Use: Two Longitudinal Studies of Excessive Internet Use, Depressive Symptoms, School Burnout and Engagement Among Finnish Early and Late Adolescents.

PubMed

Salmela-Aro, Katariina; Upadyaya, Katja; Hakkarainen, Kai; Lonka, Kirsti; Alho, Kimmo

2017-02-01

Recent research shows an increased concern with well-being at school and potential problems associated with students' use of socio-digital technologies, i.e., the mobile devices, computers, social media, and the Internet. Simultaneously with supporting creative social activities, socio-digital participation may also lead to compulsive and addictive behavioral patterns affecting both general and school-related mental health problems. Using two longitudinal data waves gathered among 1702 (53 % female) early (age 12-14) and 1636 (64 % female) late (age 16-18) Finnish adolescents, we examined cross-lagged paths between excessive internet use, school engagement and burnout, and depressive symptoms. Structural equation modeling revealed reciprocal cross-lagged paths between excessive internet use and school burnout among both adolescent groups: school burnout predicted later excessive internet use and excessive internet use predicted later school burnout. Reciprocal paths between school burnout and depressive symptoms were also found. Girls typically suffered more than boys from depressive symptoms and, in late adolescence, school burnout. Boys, in turn, more typically suffered from excessive internet use. These results show that, among adolescents, excessive internet use can be a cause of school burnout that can later spill over to depressive symptoms.

Nonlinear Dynamics in Viscoelastic Jets

NASA Astrophysics Data System (ADS)

Majmudar, Trushant; Varagnat, Matthieu; McKinley, Gareth

2008-11-01

Instabilities in free surface continuous jets of non-Newtonian fluids, although relevant for many industrial processes, remain poorly understood in terms of fundamental fluid dynamics. Inviscid, and viscous Newtonian jets have been studied in considerable detail, both theoretically and experimentally. Instability in viscous jets leads to regular periodic coiling of the jet, which exhibits a non-trivial frequency dependence with the height of the fall. Here we present a systematic study of the effect of viscoelasticity on the dynamics of continuous jets of worm-like micellar surfactant solutions of varying viscosities and elasticities. We observe complex nonlinear spatio-temporal dynamics of the jet, and uncover a transition from periodic to quasi-periodic to a multi-frequency, broad-spectrum dynamics. Beyond this regime, the jet dynamics smoothly crosses over to exhibit the ``leaping shampoo'' or the Kaye effect. We examine different dynamical regimes in terms of scaling variables, which depend on the geometry (dimensionless height), kinematics (dimensionless flow rate), and the fluid properties (elasto-gravity number) and present a regime map of the dynamics of the jet in terms of these dimensionless variables.

Nonlinear Dynamics in Viscoelastic Jets

NASA Astrophysics Data System (ADS)

Majmudar, Trushant; Varagnat, Matthieu; McKinley, Gareth

2009-03-01

Instabilities in free surface continuous jets of non-Newtonian fluids, although relevant for many industrial processes, remain poorly understood in terms of fundamental fluid dynamics. Inviscid, and viscous Newtonian jets have been studied in considerable detail, both theoretically and experimentally. Instability in viscous jets leads to regular periodic coiling of the jet, which exhibits a non-trivial frequency dependence with the height of the fall. Here we present a systematic study of the effect of viscoelasticity on the dynamics of continuous jets of worm-like micellar surfactant solutions of varying viscosities and elasticities. We observe complex nonlinear spatio-temporal dynamics of the jet, and uncover a transition from periodic to quasi-periodic to a multi-frequency, broad-spectrum dynamics. Beyond this regime, the jet dynamics smoothly crosses over to exhibit the ``leaping shampoo'' or the Kaye effect. We examine different dynamical regimes in terms of scaling variables, which depend on the geometry (dimensionless height), kinematics (dimensionless flow rate), and the fluid properties (elasto-gravity number) and present a regime map of the dynamics of the jet in terms of these dimensionless variables.

Identifying Jets Using Artifical Neural Networks

NASA Astrophysics Data System (ADS)

Rosand, Benjamin; Caines, Helen; Checa, Sofia

2017-09-01

We investigate particle jet interactions with the Quark Gluon Plasma (QGP) using artificial neural networks modeled on those used in computer image recognition. We create jet images by binning jet particles into pixels and preprocessing every image. We analyzed the jets with a Multi-layered maxout network and a convolutional network. We demonstrate each network's effectiveness in differentiating simulated quenched jets from unquenched jets, and we investigate the method that the network uses to discriminate among different quenched jet simulations. Finally, we develop a greater understanding of the physics behind quenched jets by investigating what the network learnt as well as its effectiveness in differentiating samples. Yale College Freshman Summer Research Fellowship in the Sciences and Engineering.

Depressive Symptoms in Adolescence: Longitudinal Links with Maternal Empathy and Psychological Control.

PubMed

Werner, Lente L A A; der Graaff, Jolien Van; Meeus, Wim H J; Branje, Susan J T

2016-08-01

Building on self-determination theory (Deci and Ryan in Psychological Inquiry, 11, 227-268. doi: 10.1207/S15327965PLI1104_01 , 2000), the aim of the current study was to examine the role of maternal affective and cognitive empathy in predicting adolescents' depressive symptoms, through mothers' psychological control use. Less empathic mothers may be less sensitive to adolescents' need for psychological autonomy, and thus prone to violating this need using psychological control, which may in turn predict adolescents' depressive symptoms. Moreover, according to interpersonal theory of depression (Coyne in Journal of Abnormal Psychology, 85, 186-193. doi: 10.1037/0021-843x.85.2.186 , 1976), adolescents' depressive symptoms may elicit rejecting responses, such as mothers' psychological control. For six waves, 497 adolescents (57 % boys, M age T1 = 13.03) annually completed questionnaires on depressive symptoms and maternal psychological control, while mothers reported on their empathy. Cross-lagged path analyses showed that throughout adolescence, both mothers' affective and cognitive empathy indirectly predicted boys' and girls' depressive symptoms, through psychological control. Additionally, depressive symptoms predicted psychological control for boys, and early adolescent girls. These results highlight the importance of (1) mothers' affective and cognitive empathy in predicting adolescents' depressive symptoms, and (2) taking gender into account when examining adolescent-effects.

The Aeroacoustics of Supersonic Coaxial Jets

NASA Technical Reports Server (NTRS)

Dahl, Milo D.

1994-01-01

Instability waves have been established as the dominant source of mixing noise radiating into the downstream arc of a supersonic jet when the waves have phase velocities that are supersonic relative to ambient conditions. Recent theories for supersonic jet noise have used the concepts of growing and decaying linear instability waves for predicting radiated noise. This analysis is extended to the prediction of noise radiation from supersonic coaxial jets. Since the analysis requires a known mean flow and the coaxial jet mean flow is not described easily in terms of analytic functions, a numerical prediction is made for its development. The Reynolds averaged, compressible, boundary layer equations are solved using a mixing length turbulence model. Empirical correlations are developed for the effects of velocity and temperature ratios and Mach number. Both normal and inverted velocity profile coaxial jets are considered. Comparisons with measurements for both single and coaxial jets show good agreement. The results from mean flow and stability calculations are used to predict the noise radiation from coaxial jets with different operating conditions. Comparisons are made between different coaxial jets and a single equivalent jet with the same total thrust, mass flow, and exit area. Results indicate that normal velocity profile jets can have noise reductions compared to the single equivalent jet. No noise reductions are found for inverted velocity profile jets operated at the minimum noise condition compared to the single equivalent jet. However, it is inferred that changes in area ratio may provide noise reduction benefits for inverted velocity profile jets.

Description of Jet Breakup

NASA Technical Reports Server (NTRS)

Papageorgiou, Demetrios T.

1996-01-01

In this article we review recent results on the breakup of cylindrical jets of a Newtonian fluid. Capillary forces provide the main driving mechanism and our interest is in the description of the flow as the jet pinches to form drops. The approach is to describe such topological singularities by constructing local (in time and space) similarity solutions from the governing equations. This is described for breakup according to the Euler, Stokes or Navier-Stokes equations. It is found that slender jet theories can be applied when viscosity is present, but for inviscid jets the local shape of the jet at breakup is most likely of a non-slender geometry. Systems of one-dimensional models of the governing equations are solved numerically in order to illustrate these differences.

Lagged correlation networks

NASA Astrophysics Data System (ADS)

Curme, Chester

Technological advances have provided scientists with large high-dimensional datasets that describe the behaviors of complex systems: from the statistics of energy levels in complex quantum systems, to the time-dependent transcription of genes, to price fluctuations among assets in a financial market. In this environment, where it may be difficult to infer the joint distribution of the data, network science has flourished as a way to gain insight into the structure and organization of such systems by focusing on pairwise interactions. This work focuses on a particular setting, in which a system is described by multivariate time series data. We consider time-lagged correlations among elements in this system, in such a way that the measured interactions among elements are asymmetric. Finally, we allow these interactions to be characteristically weak, so that statistical uncertainties may be important to consider when inferring the structure of the system. We introduce a methodology for constructing statistically validated networks to describe such a system, extend the methodology to accommodate interactions with a periodic component, and show how consideration of bipartite community structures in these networks can aid in the construction of robust statistical models. An example of such a system is a financial market, in which high frequency returns data may be used to describe contagion, or the spreading of shocks in price among assets. These data provide the experimental testing ground for our methodology. We study NYSE data from both the present day and one decade ago, examine the time scales over which the validated lagged correlation networks exist, and relate differences in the topological properties of the networks to an increasing economic efficiency. We uncover daily periodicities in the validated interactions, and relate our findings to explanations of the Epps Effect, an empirical phenomenon of financial time series. We also study bipartite community

[Complexity and its integrative effects of the time lags of environment factors affecting Larix gmelinii stem sap flow].

PubMed

Wang, Hui-Mei; Sun, Wei; Zu, Yuan-Gang; Wang, Wen-Jie

2011-12-01

Based on the one-year (2005) observations with a frequency of half hour on the stem sap flow of Larix gmelinii plantation trees planted in 1969 and the related environmental factors air humidity (RH), air temperature (T(air)), photosynthetic components active radiation (PAR), soil temperature (T(soil)), and soil moisture (TDR), principal analysis (PCA) and correction analysis were made on the time lag effect of the stem flow in different seasons (26 days of each season) and in a year via dislocation analysis, with the complexity and its integrative effects of the time lags of environment factors affecting the stem sap flow approached. The results showed that in different seasons and for different environmental factors, the time lag effect varied obviously. In general, the time lag of PAR was 0.5-1 hour ahead of sap flow, that of T(air) and RH was 0-2 hours ahead of or behind the sap flow, and the time lags of T(soil) and TDR were much longer or sometimes undetectable. Because of the complexity of the time lags, no evident improvements were observed in the linear correlations (R2, slope, and intercept) when the time lags based on short-term (20 days) data were used to correct the time lags based on whole year data. However, obvious improvements were found in the standardized and non-standardized correlation coefficients in stepwise multiple regressions, i.e., the time lag corrections could improve the effects of RH, but decreased the effects of PAR, T(air), and T(soil). PCA could be used to simplify the complexity. The first and the second principal components could stand for over 75% information of all the environmental factors in different seasons and in whole year. The time lags of both the first and the second principal components were 1-1.5 hours in advance of the sap flow, except in winter (no time lag effect).

30 CFR 57.7801 - Jet drills.

Code of Federal Regulations, 2014 CFR

2014-07-01

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30 CFR 56.7801 - Jet drills.

Code of Federal Regulations, 2013 CFR

2013-07-01

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30 CFR 56.7801 - Jet drills.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system to...

30 CFR 57.7801 - Jet drills.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a) A...

30 CFR 57.7801 - Jet drills.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a) A...

30 CFR 56.7801 - Jet drills.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system to...

30 CFR 57.7801 - Jet drills.

Code of Federal Regulations, 2010 CFR

2010-07-01

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30 CFR 56.7801 - Jet drills.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system to...

30 CFR 57.7801 - Jet drills.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a) A...

30 CFR 56.7801 - Jet drills.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system to...

Effect of phase lag on cyclic durability of laminated composite

NASA Astrophysics Data System (ADS)

Andersons, Janis; Limonov, V.; Tamuzs, Vitants

1992-07-01

Theoretical and experimental results on fatigue of laminated fiber reinforced composites under out-of-phase, biaxial cyclic loading are presented. Experiments were carried out on tubular filament wound samples of epoxy matrix/organic (Kevlar type) fiber composites. Fatigue strength under two different loading modes, namely cyclic torsion combined with axial tension or compression, was investigated for phase lags psi = 0, pi/2, and pi. Durability was shown to decrease with increasing phase shift both for axial tension (R = 0.1) and compression (R = 10). A matrix failure criterion was proposed for a unidirectionally reinforced ply, and the ply discount method was modified to account for phase lag. Calculated S-N curves agree reasonably well with experimental data.

Physics of liquid jets

NASA Astrophysics Data System (ADS)

Eggers, Jens; Villermaux, Emmanuel

2008-03-01

Jets, i.e. collimated streams of matter, occur from the microscale up to the large-scale structure of the universe. Our focus will be mostly on surface tension effects, which result from the cohesive properties of liquids. Paradoxically, cohesive forces promote the breakup of jets, widely encountered in nature, technology and basic science, for example in nuclear fission, DNA sampling, medical diagnostics, sprays, agricultural irrigation and jet engine technology. Liquid jets thus serve as a paradigm for free-surface motion, hydrodynamic instability and singularity formation leading to drop breakup. In addition to their practical usefulness, jets are an ideal probe for liquid properties, such as surface tension, viscosity or non-Newtonian rheology. They also arise from the last but one topology change of liquid masses bursting into sprays. Jet dynamics are sensitive to the turbulent or thermal excitation of the fluid, as well as to the surrounding gas or fluid medium. The aim of this review is to provide a unified description of the fundamental and the technological aspects of these subjects.

Radiation from Relativistic Jets

NASA Technical Reports Server (NTRS)

Nishikawa, K.-I.; Mizuno, Y.; Hardee, P.; Sol, H.; Medvedev, M.; Zhang, B.; Nordlund, A.; Frederiksen, J. T.; Fishman, G. J.; Preece, R.

2008-01-01

Nonthermal radiation observed from astrophysical systems containing relativistic jets and shocks, e.g., gamma-ray bursts (GRBs), active galactic nuclei (AGNs), and Galactic microquasar systems usually have power-law emission spectra. Recent PIC simulations of relativistic electron-ion (electron-positron) jets injected into a stationary medium show that particle acceleration occurs within the downstream jet. In the presence of relativistic jets, instabilities such as the Buneman instability, other two-streaming instability, and the Weibel (filamentation) instability create collisionless shocks, which are responsible for particle (electron, positron, and ion) acceleration. The simulation results show that the Weibel instability is responsible for generating and amplifying highly nonuniform, small-scale magnetic fields. These magnetic fields contribute to the electron's transverse deflection behind the jet head. The 'jitter' radiation from deflected electrons in small-scale magnetic fields has different properties than synchrotron radiation which is calculated in a uniform magnetic field. This jitter radiation, a case of diffusive synchrotron radiation, may be important to understand the complex time evolution and/or spectral structure in gamma-ray bursts, relativistic jets, and supernova remnants.

Relativistic Jets from Collapsars

NASA Astrophysics Data System (ADS)

Aloy, M. A.; Müller, E.; Ibáñez, J. M.; Martí, J. M.; MacFadyen, A.

2000-03-01

Using a collapsar progenitor model of MacFadyen & Woosley, we have simulated the propagation of an axisymmetric jet through a collapsing rotating massive star with the GENESIS multidimensional relativistic hydrodynamic code. The jet forms as a consequence of an assumed (constant or variable) energy deposition in the range of 1050-1051 ergs s-1 within a 30 deg cone around the rotation axis. The jet flow is strongly beamed (approximately less than a few degrees), spatially inhomogeneous, and time dependent. The jet reaches the surface of the stellar progenitor (R*=2.98x1010 cm) intact. At breakout, the maximum Lorentz factor of the jet flow is 33. After breakout, the jet accelerates into the circumstellar medium, whose density is assumed to decrease exponentially and then become constant, ρext=10-5 g cm-3. Outside the star, the flow begins to expand laterally also (v~c), but the beam remains very well collimated. At a distance of 2.54 R*, where the simulation ends, the Lorentz factor has increased to 44.

Time lags between crown and basal sap flows in tropical lianas and co-occurring trees.

PubMed

Chen, Ya-Jun; Bongers, Frans; Tomlinson, Kyle; Fan, Ze-Xin; Lin, Hua; Zhang, Shu-Bin; Zheng, Yu-Long; Li, Yang-Ping; Cao, Kun-Fang; Zhang, Jiao-Lin

2016-06-01

Water storage in the stems of woody plants contributes to their responses to short-term water shortages. To estimate the contribution of water storage to the daily water budget of trees, time lags of sap flow between different positions of trunk are used as a proxy of stem water storage. In lianas, another large group of woody species, it has rarely been studied whether stored water functions in their daily water use, despite their increasing roles in the carbon and water dynamics of tropical forests caused by their increasing abundance. We hypothesized that lianas would exhibit large time lags due to their extremely long stems, wide vessels and large volume of parenchyma in the stem. We examined time lags in sap flow, diel changes of stem volumetric water content (VWC) and biophysical properties of sapwood of 19 lianas and 26 co-occurring trees from 27 species in 4 forests (karst, tropical seasonal, flood plain and savanna) during a wet season. The plants varied in height/length from <5 to >60 m. The results showed that lianas had significantly higher saturated water content (SWC) and much lower wood density than trees. Seven of 19 liana individuals had no time lags; in contrast, only 3 of 26 tree individuals had no time lags. In general, lianas had shorter time lags than trees in our data set, but this difference was not significant for our most conservative analyses. Across trees and lianas, time lag duration increased with diurnal maximum changeable VWC but was independent of the body size, path length, wood density and SWC. The results suggest that in most lianas, internal stem water storage contributes little to daily water budget, while trees may rely more on stored water in the stem. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Free compressible jet investigation

NASA Astrophysics Data System (ADS)

De Gregorio, Fabrizio

2014-03-01

The nozzle pressure ratio (NPR) effect on a supersonic turbulent jet was investigated. A dedicated convergent/divergent nozzle together with a flow feeding system was designed and manufactured. A nozzle Mach exit of M j = 1.5 was selected in order to obtain a convective Mach number of M c = 0.6. The flow was investigated for over-expanded, correctly expanded and under-expanded jet conditions. Mach number, total temperature and flow velocity measurements were carried out in order to characterise the jet behaviour. The inlet conditions of the jet flow were monitored in order to calculate the nozzle exit speed of sound and evaluate the mean Mach number distribution starting from the flow velocity data. A detailed analysis of the Mach results obtained by a static Pitot probe and by a particle image velocimetry measurement system was carried out. The mean flow velocity was investigated, and the axial Mach decay and the spreading rate were associated with the flow structures and with the compressibility effects. Aerodynamics of the different jet conditions was evaluated, and the shock cells structures were detected and discussed correlating the jet structure to the flow fluctuation and local turbulence. The longitudinal and radial distribution of the total temperature was investigated, and the temperature profiles were analysed and discussed. The total temperature behaviour was correlated to the turbulent phenomena and to the NPR jet conditions. Self-similarity condition was encountered and discussed for the over-expanded jet. Compressibility effects on the local turbulence, on the turbulent kinetic energy and on the Reynolds tensor were discussed.

Flow cytometer jet monitor system

DOEpatents

Van den Engh, Ger

1997-01-01

A direct jet monitor illuminates the jet of a flow cytometer in a monitor wavelength band which is substantially separate from the substance wavelength band. When a laser is used to cause fluorescence of the substance, it may be appropriate to use an infrared source to illuminate the jet and thus optically monitor the conditions within the jet through a CCD camera or the like. This optical monitoring may be provided to some type of controller or feedback system which automatically changes either the horizontal location of the jet, the point at which droplet separation occurs, or some other condition within the jet in order to maintain optimum conditions. The direct jet monitor may be operated simultaneously with the substance property sensing and analysis system so that continuous monitoring may be achieved without interfering with the substance data gathering and may be configured so as to allow the front of the analysis or free fall area to be unobstructed during processing.

X-ray short-time lags in the Fe-K energy band produced by scattering clouds in active galactic nuclei

NASA Astrophysics Data System (ADS)

Mizumoto, Misaki; Done, Chris; Hagino, Kouichi; Ebisawa, Ken; Tsujimoto, Masahiro; Odaka, Hirokazu

2018-07-01

X-rays illuminating the accretion disc in active galactic nuclei give rise to an iron K line and its associated reflection spectrum that are lagged behind the continuum variability by the light-travel time from the source to the disc. The measured lag time-scales in the iron band can be as short as ˜Rg/c, where Rg is the gravitational radius, which is often interpreted as evidence for a very small continuum source close to the event horizon of a rapidly spinning black hole. However, the short lags can also be produced by reflection from more distant material, because the primary photons with no time-delay dilute the time-lags caused by the reprocessed photons. We perform a Monte Carlo simulation to calculate the dilution effect in the X-ray reverberation lags from a half-shell of neutral material placed at 100 Rg from the central source. This gives lags of ˜2 Rg/c, but the iron line is a distinctly narrow feature in the lag-energy plot, whereas the data often show a broader line. We show that both the short lag and the line broadening can be reproduced, if the scattering material is outflowing at ˜0.1c. The velocity structure in the wind can also give shifts in the line profile in the lag-energy plot calculated at different frequencies. Hence we propose that the observed broad iron reverberation lags and shifts in profile as a function of frequency of variability can arise from a disc wind at fairly large distances from the X-ray source.

X-ray short-time lags in the Fe-K energy band produced by scattering clouds in active galactic nuclei

NASA Astrophysics Data System (ADS)

Mizumoto, Misaki; Done, Chris; Hagino, Kouichi; Ebisawa, Ken; Tsujimoto, Masahiro; Odaka, Hirokazu

2018-05-01

X-rays illuminating the accretion disc in active galactic nuclei give rise to an iron K line and its associated reflection spectrum which are lagged behind the continuum variability by the light-travel time from the source to the disc. The measured lag timescales in the iron band can be as short as ˜Rg/c, where Rg is the gravitational radius, which is often interpreted as evidence for a very small continuum source close to the event horizon of a rapidly spinning black hole. However, the short lags can also be produced by reflection from more distant material, because the primary photons with no time-delay dilute the time-lags caused by the reprocessed photons. We perform a Monte-Carlo simulation to calculate the dilution effect in the X-ray reverberation lags from a half-shell of neutral material placed at 100 Rg from the central source. This gives lags of ˜2 Rg/c, but the iron line is a distinctly narrow feature in the lag-energy plot, whereas the data often show a broader line. We show that both the short lag and the line broadening can be reproduced if the scattering material is outflowing at ˜0.1c. The velocity structure in the wind can also give shifts in the line profile in the lag-energy plot calculated at different frequencies. Hence we propose that the observed broad iron reverberation lags and shifts in profile as a function of frequency of variability can arise from a disc wind at fairly large distances from the X-ray source.

Nonlinear flap-lag axial equations of a rotating beam

NASA Technical Reports Server (NTRS)

Kaza, K. R. V.; Kvaternik, R. G.

1977-01-01

It is possible to identify essentially four approaches by which analysts have established either the linear or nonlinear governing equations of motion for a particular problem related to the dynamics of rotating elastic bodies. The approaches include the effective applied load artifice in combination with a variational principle and the use of Newton's second law, written as D'Alembert's principle, applied to the deformed configuration. A third approach is a variational method in which nonlinear strain-displacement relations and a first-degree displacement field are used. The method introduced by Vigneron (1975) for deriving the linear flap-lag equations of a rotating beam constitutes the fourth approach. The reported investigation shows that all four approaches make use of the geometric nonlinear theory of elasticity. An alternative method for deriving the nonlinear coupled flap-lag-axial equations of motion is also discussed.

Tyrosinase autoactivation and the problem of the lag period.

PubMed

Naish-Byfield, S; Riley, P A

1998-06-01

Evidence is presented for the binding of the quinone oxidation product of the monohydric phenol substrate, 4-hydroxyanisole, to mushroom tyrosinase. Column chromatography and SDS-PAGE separation showed labelling of the enzyme when incubated with 14C ring-labelled 4-hydroxyanisole. It is proposed that covalent binding to the enzyme and other proteins is through reaction of accessible nucleophilic groups, including thiols and amino groups, with the anisylquinone. This reductive addition enables the indirect generation of the catecholic substrate, which acts as an electron donor for the bicupric active site of met-tyrosinase and explains the lag kinetics of tyrosinase oxidation of non-cyclizing substrates. The effects of diluting the enzyme or the addition of amino acids on the lag period was consistent with a mechanism involving indirect generation of the dihydric phenol, which acts as the met-enzyme-recruiting substrate.

Longitudinal associations between post-traumatic distress and depressive symptoms following a traumatic event: a test of three models.

PubMed

Schindel-Allon, I; Aderka, I M; Shahar, G; Stein, M; Gilboa-Schechtman, E

2010-10-01

Symptoms of post-traumatic stress disorder (PTSD) and depression are highly co-morbid following a traumatic event. Nevertheless, decisive evidence regarding the direction of the relationship between these clinical entities is missing. The aim of the present study was to examine the nature of this relationship by comparing a synchronous change model (PTSD and depression are time synchronous, possibly stemming from a third common factor) with a demoralization model (i.e. PTSD symptoms causing depression) and a depressogenic model (i.e. depressive symptoms causing PTSD symptoms). Israeli adult victims of single-event traumas (n=156) were assessed on measures of PTSD and depression at 2, 4 and 12 weeks post-event. A cross-lagged structural equation modeling (SEM) analysis provided results consistent with the synchronous change model and the depressogenic model. Depressive symptoms may play an important role in the development of post-traumatic symptoms.

The prescription pickup lag, an automatic prescription refill program, and community pharmacy operations.

PubMed

Lester, Corey A; Chui, Michelle A

2016-01-01

To determine the effect of an automatic prescription refill program on the prescription pickup lag in community pharmacy. A post-only quasi-experimental design comparing automatic and manual refill prescription cohorts for each of the 3 Centers for Medicare and Medicaid medication adherence metrics. A 29-store community pharmacy chain in the Midwest. Community-dwelling patients over the age of 65 years receiving prescription medications included in the statin, renin-angiotensin-aldosterone system antagonist, or non-insulin diabetes adherence metrics. An automatic prescription refill program that initiated prescription refills on a standardized, recurrent basis, eliminating the need for patients to phone in or drop off prescription refills. The prescription pickup lag, defined as the number of days between a prescription being adjudicated in the pharmacy and the prescription being picked up by the patient. A total of 37,207 prescription fills were examined. There were 20.5%, 22.4%, and 23.3% of patients enrolled in the automatic prescription refill program for the statin, renin-angiotensin-aldosterone system antagonist, and diabetes adherence metrics, respectively. Prescriptions in the automatic prescription refill cohorts experienced a median pickup lag of 7 days compared with 1 day for the manual refill prescriptions. 35.2% of all manual refill prescriptions had a pickup lag of 0 days compared with 13% for automatic refills. However, 15.4% of automatic prescription refills had a pickup lag of greater than 14 days, compared with 4.8% of manual refills. Prescriptions in the automatic prescription refill programs were associated with a significantly longer amount of time in the pharmacy before being picked up by the patient. This increased pickup lag may contribute positively by smoothing out workload demands of pharmacy staff, but may contribute negatively owing to an increased amount of rework and greater inventory requirements. Copyright © 2016 American

ARE THE kHz QPO LAGS IN NEUTRON STAR 4U 1608–52 DUE TO REVERBERATION?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cackett, Edward M., E-mail: ecackett@wayne.edu

2016-08-01

X-ray reverberation lags have recently been discovered in both active galactic nuclei (AGNs) and black hole X-ray binaries. A recent study of the neutron star low-mass X-ray binary (LMXB) 4U 1608 52 has also shown significant lags, whose properties hint at a reverberation origin. Here, we adapt general relativistic ray tracing impulse response functions used to model X-ray reverberation in AGNs for neutron star LMXBs. Assuming that relativistic reflection forms the broad iron line and associated reflection continuum, we use reflection fits to the energy spectrum along with the impulse response functions to calculate the expected lags as a functionmore » of energy over the range of observed kHz quasi-periodic oscillation (QPO) frequencies in 4U 1608 52. We find that the lag energy spectrum is expected to increase with increasing energy above 8 keV, while the observed lags in 4U 1608 52 show the opposite behavior. This demonstrates that the lags in the lower kHz QPO of 4U 1608 52 are not solely due to reverberation. We do note, however, that the models appear to be more consistent with the much flatter lag energy spectrum observed in the upper kHz QPO of several neutron star LMXBs, suggesting that lower and upper kHz QPOs may have different origins.« less

A Lagging Model for Describing Drawdown Induced by a Constant-Rate Pumping in a Leaky Confined Aquifer

NASA Astrophysics Data System (ADS)

Lin, Ye-Chen; Yeh, Hund-Der

2017-10-01

This study proposes a generalized Darcy's law with considering phase lags in both the water flux and drawdown gradient to develop a lagging flow model for describing drawdown induced by constant-rate pumping (CRP) in a leaky confined aquifer. The present model has a mathematical formulation similar to the dual-porosity model. The Laplace-domain solution of the model with the effect of wellbore storage is derived by the Laplace transform method. The time-domain solution for the case of neglecting the wellbore storage and well radius is developed by the use of Laplace transform and Weber transform. The results of sensitivity analysis based on the solution indicate that the drawdown is very sensitive to the change in each of the transmissivity and storativity. Also, a study for the lagging effect on the drawdown indicates that its influence is significant associated with the lag times. The present solution is also employed to analyze a data set taken from a CRP test conducted in a fractured aquifer in South Dakota, USA. The results show the prediction of this new solution with considering the phase lags has very good fit to the field data, especially at early pumping time. In addition, the phase lags seem to have a scale effect as indicated in the results. In other words, the lagging behavior is positively correlated with the observed distance in the Madison aquifer.

Azimuthal correlations for inclusive 2-jet, 3-jet, and 4-jet events in pp collisions at $$\\sqrt{s}= $$ 13 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, Albert M; et al.

Azimuthal correlations between the two jets with the largest transverse momentamore » $$ {p_{\\mathrm{T}}} $$ in inclusive 2-, 3-, and 4-jet events are presented for several regions of the leading jet $$ {p_{\\mathrm{T}}} $$ up to 4 TeV. For 3- and 4-jet scenarios, measurements of the minimum azimuthal angles between any two of the three or four leading $$ {p_{\\mathrm{T}}} $$ jets are also presented. The analysis is based on data from proton-proton collisions collected by the CMS Collaboration at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb$$^{-1}$$. Calculations based on leading-order matrix elements supplemented with parton showering and hadronization do not fully describe the data, so next-to-leading-order calculations matched with parton shower and hadronization models are needed to better describe the measured distributions. Furthermore, we show that azimuthal jet correlations are sensitive to details of the parton showering, hadronization, and multiparton interactions. A next-to-leading-order calculation matched with parton showers in the MC@NLO method, as implemented in HERWIG 7, gives a better overall description of the measurements than the POWHEG method.« less

Overactive bladder (OAB): A symptom in search of a disease - Its relationship to specific lower urinary tract symptoms and conditions.

PubMed

Van Batavia, Jason P; Combs, Andrew J; Fast, Angela M; Glassberg, Kenneth I

2017-06-01

The ICCS defines OAB by the subjective symptom of urgency; detrusor overactivity (DO) is only implied. While no other symptom is required, OAB can also be associated with urinary frequency, decreased functional bladder capacity, and incontinence. We sought to determine how often these associated findings occur in OAB and what if any uroflow/EMG-defined conditions are found to be associated with it. The charts of 548 children (231M, 318F; mean age 9.0 years, range 3-20) who presented sequentially with urgency (OAB), over a period of 2 years, were reviewed paying particular attention to whether or not there was a history of frequency and/or daytime incontinence in addition to the urgency. All patients had been previously diagnosed with one of the following four lower urinary tract (LUT) conditions based on specific uroflow/EMG findings: 1. dysfunctional voiding (DV; active pelvic floor EMG during voiding); 2. idiopathic detrusor overactivity disorder (IDOD; OAB with a short EMG lag time (<2 s), and quiet pelvic floor EMG during voiding); 3. detrusor underutilization disorder (DUD; willful infrequent voiding with %EBC >125%, quiet EMG during voiding); and 4. primary bladder neck dysfunction (PBND; prolonged EMG lag time (>6 s), quiet EMG during voiding, and depressed uroflow curve). Mean %EBC was compared between patients with urgency alone and those with urgency plus other symptoms. Any association with gender was analyzed. Urgency was accompanied by either frequency or daytime incontinence in 91% of the children (summary Table). Daytime incontinence was reported in 398 (72.6%) and frequency in 268 (48.9%). Mean %EBC was 80.9. Females were more likely to report daytime incontinence (76.7% vs. 66.7%, p = 0.02) and frequency was found more often in males (63.6% vs. 38.1%, p < 0.001). %EBC was less in males (70.0 vs. 88.8, p < 0.001). The majority of patients with urgency were diagnosed with IDOD (62%), while 15% had DV, 5% PBND, 3% DUD, and in 15%, the uroflow

Noise shielding by a hot subsonic jet

NASA Technical Reports Server (NTRS)

Vijayaraghavan, A.; Parthasarathy, S. P.

1981-01-01

An analysis is conducted of the shielding of the noise emitted by a high speed round jet by a hot, subsonic, semicircular jet. A plane wave front in the primary jet is resolved into elementary plane waves which undergo multiple reflections at the jet boundaries of the primary and the shielding jets. The jet boundaries are idealized to be vortex sheets. The far field sound is evaluated asymptotically by a superposition of the waves that penetrate the shielding jet. The angular directivities are plotted for several values of jet temperature and velocity to examine the effectiveness of shielding by the semicircular jet layer.

Longitudinal Links between Fathers' and Mothers' Harsh Verbal Discipline and Adolescents' Conduct Problems and Depressive Symptoms

ERIC Educational Resources Information Center

Wang, Ming-Te; Kenny, Sarah

2014-01-01

This study used cross-lagged modeling to examine reciprocal relations between maternal and paternal harsh verbal discipline and adolescents' conduct problems and depressive symptoms. Data were from a sample of 976 two-parent families and their children (51% males; 54% European American, 40% African American). Mothers' and fathers'…

Relations Among Intimate Partner Violence, Maternal Depressive Symptoms, and Maternal Parenting Behaviors

PubMed Central

Gustafsson, Hanna C.; Cox, Martha J.

2013-01-01

The authors examined the relations among intimate partner violence (IPV), maternal depressive symptoms, and maternal harsh intrusive parenting. Using a cross-lagged, autoregressive path model, they sought to clarify the directionality of the relations among these 3 variables over the first 2 years of the child’s life. The results indicated that, in this diverse sample of families living in predominantly low-income rural communities (N = 705), higher levels of early IPV were associated with increases in maternal depressive symptoms, which in turn were associated with increases in maternal harsh intrusive parenting behaviors. These findings suggest that interventions aimed at improving the parenting of women exposed to domestic violence may want to simultaneously target IPV and depressive symptomatology. PMID:23869110

Longitudinal Links between Fathers' and Mothers' Harsh Verbal Discipline and Adolescents' Conduct Problems and Depressive Symptoms

PubMed Central

Wang, Ming-Te; Kenny, Sarah

2013-01-01

This study used cross-lagged modeling to examine reciprocal relations between maternal and paternal harsh verbal discipline and adolescents' conduct problems and depressive symptoms. Data were from a sample of 976 two-parent families and their children (51% males; 54% European American, 40% African American). Mothers' and fathers' harsh verbal discipline at age 13 predicted an increase in adolescent conduct problems and depressive symptoms between ages 13 and 14. A child effect was also present, with adolescent misconduct at age 13 predicting increases in mothers' and fathers' harsh verbal discipline between ages 13 and 14. Furthermore, maternal and paternal warmth did not moderate the longitudinal associations between mothers' and fathers' use of harsh verbal discipline and adolescent conduct problems and depressive symptoms. PMID:24001259

Chimera and modulated drift states in a ring of nonlocally coupled oscillators with heterogeneous phase lags

NASA Astrophysics Data System (ADS)

Choe, Chol-Ung; Kim, Ryong-Son; Ri, Ji-Song

2017-09-01

We consider a ring of phase oscillators with nonlocal coupling strength and heterogeneous phase lags. We analyze the effects of heterogeneity in the phase lags on the existence and stability of a variety of steady states. A nonlocal coupling with heterogeneous phase lags that allows the system to be solved analytically is suggested and the stability of solutions along the Ott-Antonsen invariant manifold is explored. We present a complete bifurcation diagram for stationary patterns including the uniform drift and modulated drift states as well as chimera state, which reveals that the stable modulated drift state and a continuum of metastable drift states could occur due to the heterogeneity of the phase lags. We verify our theoretical results using the direct numerical simulations of the model system.

A comparison of the noise produced by a small jet on a moving vehicle with that in a free jet. [jet mixing noise

NASA Technical Reports Server (NTRS)

Norum, T. D.

1978-01-01

A 2.54 cm (1.00 in.) nozzle supplied with nitrogen was mounted above an automobile and driven over an asphalt roadway past stationary microphones in an attempt to quantify the effects of the vehicle motion on jet mixing noise. The nozzle was then tested in the Langley anechoic noise facility with a large free jet simulating the relative motion. The results are compared for these two methods of investigating forward speed effects on jet mixing noise. The vehicle results indicate a noise with forward speed throughout the Doppler-shifted static spectrum. This decrease across the entire frequency range was also apparent in the free-jet results. The similarity of the results indicates that the effects of flight on jet mixing noise can be predicted by simulation of forward speed with a free jet. Overall sound pressure levels were found to decrease with forward speed at all observation angles for both methods of testing.

W + Jet Production at Cdf

NASA Astrophysics Data System (ADS)

Messina, Andrea

2007-01-01

The cross section for the inclusive production of W bosons in association with jets in pbar {p} collisions at √ {s} = 1.96\\ TeV using the Collider Detector at Fermilab (CDF II) is presented. The measurement is based on an integrated luminosity of 320 pb-1, and includes events with up to 4 or more jets. In each jet multiplicity sample the differential and cumulative cross sections with respect to the transverse energy of the ith-jet are measured. For W + ≥ 2 jets the differential cross section with respect to the 2-leading jets invariant mass mj1j2 and angular separation ΔRj1j2 is also reported. The data are compared to predictions from Monte Carlo simulations.

Psychometric schizotypy predicts psychotic-like, paranoid, and negative symptoms in daily life.

PubMed

Barrantes-Vidal, Neus; Chun, Charlotte A; Myin-Germeys, Inez; Kwapil, Thomas R

2013-11-01

Positive and negative schizotypy exhibit differential patterns of impairment in social relations, affect, and functioning in daily life. However, studies have not examined the association of schizotypy with real-world expression of psychotic-like, paranoid, and negative symptoms. The present study employed experience-sampling methodology (ESM) to assess positive and negative schizotypy in daily life in a nonclinical sample of 206 Spanish young adults. Participants were prompted randomly 8 times daily for 1 week to complete assessments of their current symptoms and experiences. Positive schizotypy was associated with psychotic-like and paranoid symptoms in daily life. Negative schizotypy was associated with a subset of these symptoms and with negative symptoms in daily life. Momentary stress was associated with psychotic-like and paranoid symptoms, but only for those high in positive schizotypy. Social stress predicted momentary psychotic-like symptoms in both positive and negative schizotypy. Time-lagged analyses indicated that stress at the preceding signal predicted psychotic-like symptoms at the current assessment, but only for individuals high in positive schizotypy. The results are consistent with models linking stress sensitivity with the experience of psychotic symptoms. The findings provide cross-cultural support for the multidimensional model of schizotypy and schizophrenia. Furthermore, the findings demonstrate that ESM is an effective method for predicting the experience of psychotic-like symptoms, as well as their precursors, in daily life. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Air pollution is associated with primary health care visits for asthma in Sweden: A case-crossover design with a distributed lag non-linear model.

PubMed

Taj, Tahir; Jakobsson, Kristina; Stroh, Emilie; Oudin, Anna

2016-05-01

Air pollution can increase the symptoms of asthma and has an acute effect on the number of emergency room visits and hospital admissions because of asthma, but little is known about the effect of air pollution on the number of primary health care (PHC) visits for asthma. To investigate the association between air pollution and the number of PHC visits for asthma in Scania, southern Sweden. Data on daily PHC visits for asthma were obtained from a regional healthcare database in Scania, which covers approximately half a million people. Air pollution data from 2005 to 2010 were obtained from six urban background stations. We used a case-crossover study design and a distributed lag non-linear model in the analysis. The air pollution levels were generally within the EU air quality guidelines. The mean number of daily PHC visits for asthma was 34. The number of PHC visits increased by 5% (95% confidence interval (CI): 3.91-6.25%) with every 10µg m(-3) increase in daily mean NO2 lag (0-15), suggesting that daily air pollution levels are associated with PHC visits for asthma. Even though the air quality in Scania between 2005 and 2010 was within EU's guidelines, the number of PHC visits for asthma increased with increasing levels of air pollution. This suggests that as well as increasing hospital and emergency room visits, air pollution increases the burden on PHC due to milder symptoms of asthma. Copyright © 2016 Elsevier Ltd. All rights reserved.

Investigating effects of hydroxypropyl methylcellulose (HPMC) molecular weight grades on lag time of press-coated ethylcellulose tablets.

PubMed

Patadia, Riddhish; Vora, Chintan; Mittal, Karan; Mashru, Rajashree

2016-11-01

The research undertaken exemplifies the effects of hydroxypropyl methylcellulose (HPMC) molecular weight (MW) grades of on lag time of press-coated ethylcellulose (EC) tablets. The formulation comprised an immediate release core (containing prednisone as a model drug) surrounded by compression coating with variegated EC-HPMC blends. Five selected HPMC grades (E5, E15, E50, K100LV and K4M) were explored at three different concentrations (10% w/w, 20% w/w and 30% w/w in outer coat) to understand their effects on lag time and drug release. In vitro drug release testing demonstrated that, with increase in concentration of E5 and E15, up to 30% w/w, the mean lag time decreased progressively; whereas with remaining grades, the mean lag time initially decreased up to 20% w/w level and thereafter increased for 30% w/w level. Importantly, with increase in HPMC concentration in the outer coat, the variability in lag time (%RSD; n = 6) was decreased for each of E5, E15 and E50, whereas increased for K100LV and K4M. In general, the variability in lag time was increased with increase in HPMC MW at studied concentration levels. Markedly, tablets with 30% w/w K4M in outer coat exhibited slight premature release (before the rupture of outer coat) along with high variability in lag time. Overall, the study concluded that low MW HPMCs (E5, E15 and E50) were found rather efficient than higher MW HPMCs for developing robust EC-based press-coated pulsatile release formulations where precise lag time followed by sharp burst release is desired.

A lagged variable model for characterizing temporally dynamic export of legacy anthropogenic nitrogen from watersheds to rivers.

PubMed

Chen, Dingjiang; Guo, Yi; Hu, Minpeng; Dahlgren, Randy A

2015-08-01

Legacy nitrogen (N) sources originating from anthropogenic N inputs (NANI) may be a major cause of increasing riverine N exports in many regions, despite a significant decline in NANI. However, little quantitative knowledge exists concerning the lag effect of NANI on riverine N export. As a result, the N leaching lag effect is not well represented in most current watershed models. This study developed a lagged variable model (LVM) to address temporally dynamic export of watershed NANI to rivers. Employing a Koyck transformation approach used in economic analyses, the LVM expresses the indefinite number of lag terms from previous years' NANI with a lag term that incorporates the previous year's riverine N flux, enabling us to inversely calibrate model parameters from measurable variables using Bayesian statistics. Applying the LVM to the upper Jiaojiang watershed in eastern China for 1980-2010 indicated that ~97% of riverine export of annual NANI occurred in the current year and succeeding 10 years (~11 years lag time) and ~72% of annual riverine N flux was derived from previous years' NANI. Existing NANI over the 1993-2010 period would have required a 22% reduction to attain the target TN level (1.0 mg N L(-1)), guiding watershed N source controls considering the lag effect. The LVM was developed with parsimony of model structure and parameters (only four parameters in this study); thus, it is easy to develop and apply in other watersheds. The LVM provides a simple and effective tool for quantifying the lag effect of anthropogenic N input on riverine export in support of efficient development and evaluation of watershed N control strategies.

Adolescents’ Pregnancy Intentions, Wantedness, and Regret: Cross-Lagged Relations With Mental Health and Harsh Parenting

PubMed Central

East, Patricia L.; Chien, Nina C.; Barber, Jennifer S.

2011-01-01

The authors used cross-lagged analyses to examine the across-time influences on and consequences of adolescents’ pregnancy intentions, wantedness, and regret. One hundred pregnant Latina adolescents were studied during pregnancy and at 6 and 12 months postpartum. The results revealed 4 main findings: (a) similar to what has been found in adult women, adolescents’ lower prenatal pregnancy intendedness and wantedness predicted initial difficulties in parenting; (b) frequent depression symptoms predicted subsequent lower pregnancy intendedness and wantedness; (c) adolescents’ poor mental health and harsh parenting of their child predicted subsequent higher childbearing regret, and (d) high childbearing regret and parenting stress were reciprocally related across time. In addition, adolescents’ wantedness of their pregnancy declined prenatally to postbirth, and strong pregnancy intendedness and wantedness were not concurrently related to adolescents’ poor prenatal mental health. The findings reveal how adolescents’ thoughts and feelings about their pregnancies are influenced by and predictive of their mental health and parenting experiences. PMID:22544975

An experimental and analytical investigation of stall effects on flap-lag stability in forward flight

NASA Technical Reports Server (NTRS)

Nagabhushanam, J.; Gaonkar, Gopal H.; Mcnulty, Michael J.

1987-01-01

Experiments have been performed with a 1.62 m diameter hingeless rotor in a wind tunnel to investigate flap-lag stability of isolated rotors in forward flight. The three-bladed rotor model closely approaches the simple theoretical concept of a hingeless rotor as a set of rigid, articulated flap-lag blades with offset and spring restrained flap and lag hinges. Lag regressing mode stability data was obtained for advance ratios as high as 0.55 for various combinations of collective pitch and shaft angle. The prediction includes quasi-steady stall effects on rotor trim and Floquet stability analyses. Correlation between data and prediction is presented and is compared with that of an earlier study based on a linear theory without stall effects. While the results with stall effects show marked differences from the linear theory results, the stall theory still falls short of adequate agreement with the experimental data.

Expression of LAG-3 defines exhaustion of intratumoral PD-1+ T cells and correlates with poor outcome in follicular lymphoma

PubMed Central

Yang, Zhi-Zhang; Kim, Hyo Jin; Villasboas, Jose C.; Chen, Ya-Ping; Price-Troska, Tammy; Jalali, Shahrzad; Wilson, Mara; Novak, Anne J.; Ansell, Stephen M.

2017-01-01

Exhausted T-cells in follicular lymphoma (FL) typically express PD-1, but expression of PD-1 is not limited to exhausted cells. Although expected to be functionally suppressed, we found that the population of intratumoral PD-1+ T cells were predominantly responsible for production of cytokines and granules. This surprising finding prompted us to explore the involvement of LAG-3 to specifically identify functionally exhausted T cells. We found that LAG-3 was expressed on a subset of intratumoral T cells from FL and LAG-3+ T cells almost exclusively came from PD-1+ population. CyTOF analysis revealed that intratumoral LAG-3+ T cells were phenotypically heterogeneous as LAG-3 was expressed on a variety of T cell subsets. In contrast to PD-1+LAG-3- cells, intratumoral PD-1+LAG-3+ T cells exhibited reduced capacity to produce cytokines and granules. LAG-3 expression could be substantially upregulated on CD4+ or CD8+ T cells by IL-12, a cytokine that has been shown to induce T-cell exhaustion and be increased in the serum of lymphoma patients. Furthermore, we found that blockade of both PD-1 and LAG-3 signaling enhanced the function of intratumoral CD8+ T cells resulting in increased IFN-γ and IL-2 production. Clinically, LAG-3 expression on intratumoral T cells correlated with a poor outcome in FL patients. Taken together, we find that LAG-3 expression is necessary to identify the population of intratumoral PD-1+ T cells that are functionally exhausted and, in contrast, find that PD-1+LAG-3- T cells are simply activated cells that are immunologically functional. These findings may have important implications for immune checkpoint therapy in FL. PMID:28977875

Review: the environmental status and implications of the nitrate time lag in Europe and North America

NASA Astrophysics Data System (ADS)

Vero, Sara E.; Basu, Nandita B.; Van Meter, Kimberly; Richards, Karl G.; Mellander, Per-Erik; Healy, Mark G.; Fenton, Owen

2018-02-01

The efficacy of water quality policies aiming to reduce or prevent nitrate contamination of waterbodies may be constrained by the inherent delay or "time lag" of water and solute transport through unsaturated (soil) and saturated (groundwater) pathways. These delays must be quantified in order to establish realistic deadlines, thresholds and policy expectations, and to design effective best management practices. The objective of this review is to synthesise the current state of research on nitrate-related time lags in both the European and North American environmental and legislative contexts. The durations of time lags have been found to differ according to climatic, pedological, landscape and management scenarios. Elucidation of these driving factors at a watershed scale is essential where water quality is impaired or at risk. Finally, the existence of time lags is increasingly being acknowledged at a policy level and incorporated into the development of environmental legislation. However, the full impact of these time lags is not yet fully understood or appreciated, and continued outreach and education in scientific, public and policy venues is still required.

Jet fuel-induced immunotoxicity.

PubMed

Harris, D T; Sakiestewa, D; Titone, D; Robledo, R F; Young, R S; Witten, M

2000-09-01

Chronic exposure to jet fuel has been shown to cause human liver dysfunction, emotional dysfunction, abnormal electroencephalograms, shortened attention spans, and to decrease sensorimotor speed (3-5). Exposure to potential environmental toxicants such as jet fuel may have significant effects on host systems beyond those readily visible (e.g., physiology, cardiology, respiratory, etc.), e.g., the immune system. Significant changes in immune function, even if short-lived, may have serious consequences for the exposed host that may impinge affect susceptibility to infectious agents. Major alterations in immune function that are long lasting may result in an increased likelihood of development and/or progression of cancer, as well as autoimmune diseases. In the current study mice were exposed 1 h/day for 7 days to a 1000-mg/m3 concentration of aerosolized jet fuel obtained from various sources (JP-8, JP-8+100 and Jet A1) and of differing compositions to simulate occupational exposures. Twenty-four hours after the last exposure the mice were analyzed for effects on the immune system. It was observed that exposure to all jet fuel sources examined had detrimental effects on the immune system. Decreases in viable immune cell numbers and immune organ weights were found. Jet fuel exposure resulted in differential losses of immune cell populations in the thymus. Further, jet fuel exposure resulted in significantly decreased immune function, as analyzed by mitogenesis assays. Suppressed immune function could not be overcome by the addition of exogenous growth factors known to stimulate immune function. Thus, short-term, low-concentration exposure of mice to aerosolized jet fuel, regardless of source or composition, caused significant deleterious effects on the immune system.

Pulmonary function and respiratory symptoms in a population of airport workers

PubMed Central

Tunnicliffe, W. S.; O'Hickey, S. P.; Fletcher, T. J.; Miles, J. F.; Burge, P. S.; Ayres, J. G.

1999-01-01

OBJECTIVES: To assess the prevalence of respiratory symptoms and to measure spirometry in a sample of employees of Birmingham International Airport, United Kingdom, to examine whether occupational exposure to aircraft fuel or jet stream exhaust might be associated with respiratory symptoms or abnormalities of lung function. METHODS: Cross sectional survey by questionnaire and on site measurement of lung function, skin prick tests, and exhaled carbon monoxide concentrations. Occupational exposure was assigned by job title, between group comparison were made by logistic regression analysis. RESULTS: 222/680 full time employees were studied (mean age 38.6 y, 63% male, 28% current smokers, 6% self reported asthma, 19% self reported hay fever). Upper and lower respiratory tract symptoms were common and 51% had one or more positive skin tests. There were no significant differences in lung function tests between exposure groups. Between group comparisons of respiratory symptoms were restricted to male members of the medium and high exposure groups. The adjusted odds ratio (OR) for cough with phlegm and runny nose were found to be significantly associated with high exposure (OR 3.5, 95% confidence interval (95% CI) 1.23 to 9.74 and 2.9, 1.32 to 6.40 respectively) when the measured confounding effects of age and smoking, and in the case of runny nose, self reported hay fever had been taken into account. There was no obvious association between high exposure and the presence of shortness of breath or wheeze, or for the symptoms of watering eyes or stuffy nose. CONCLUSIONS: These findings support an association in male airport workers, between high occupational exposures to aviation fuel or jet stream exhaust and excess upper and lower respiratory tract symptoms, in keeping with a respiratory irritant. It is more likely that these effects reflect exposure to exhaust rather than fuel, although the effects of an unmeasured agent cannot be discounted.   PMID:10448317

Progress Toward Improving Jet Noise Predictions in Hot Jets

NASA Technical Reports Server (NTRS)

Khavaran, Abbas; Kenzakowski, Donald C.

2007-01-01

An acoustic analogy methodology for improving noise predictions in hot round jets is presented. Past approaches have often neglected the impact of temperature fluctuations on the predicted sound spectral density, which could be significant for heated jets, and this has yielded noticeable acoustic under-predictions in such cases. The governing acoustic equations adopted here are a set of linearized, inhomogeneous Euler equations. These equations are combined into a single third order linear wave operator when the base flow is considered as a locally parallel mean flow. The remaining second-order fluctuations are regarded as the equivalent sources of sound and are modeled. It is shown that the hot jet effect may be introduced primarily through a fluctuating velocity/enthalpy term. Modeling this additional source requires specialized inputs from a RANS-based flowfield simulation. The information is supplied using an extension to a baseline two equation turbulence model that predicts total enthalpy variance in addition to the standard parameters. Preliminary application of this model to a series of unheated and heated subsonic jets shows significant improvement in the acoustic predictions at the 90 degree observer angle.

Detecting PM2.5's Correlations between Neighboring Cities Using a Time-Lagged Cross-Correlation Coefficient.

PubMed

Wang, Fang; Wang, Lin; Chen, Yuming

2017-08-31

In order to investigate the time-dependent cross-correlations of fine particulate (PM2.5) series among neighboring cities in Northern China, in this paper, we propose a new cross-correlation coefficient, the time-lagged q-L dependent height crosscorrelation coefficient (denoted by p q (τ, L)), which incorporates the time-lag factor and the fluctuation amplitude information into the analogous height cross-correlation analysis coefficient. Numerical tests are performed to illustrate that the newly proposed coefficient ρ q (τ, L) can be used to detect cross-correlations between two series with time lags and to identify different range of fluctuations at which two series possess cross-correlations. Applying the new coefficient to analyze the time-dependent cross-correlations of PM2.5 series between Beijing and the three neighboring cities of Tianjin, Zhangjiakou, and Baoding, we find that time lags between the PM2.5 series with larger fluctuations are longer than those between PM2.5 series withsmaller fluctuations. Our analysis also shows that cross-correlations between the PM2.5 series of two neighboring cities are significant and the time lags between two PM2.5 series of neighboring cities are significantly non-zero. These findings providenew scientific support on the view that air pollution in neighboring cities can affect one another not simultaneously but with a time lag.

Computational Modeling And Analysis Of Synthetic Jets

NASA Technical Reports Server (NTRS)

Mittal, Rajat; Cattafesta, Lou

2005-01-01

In the last report we focused on the study of 3D synthetic jets of moderate jet aspect-ratio. Jets in quiescent and cross-flow cases were investigated. Since most of the synthetic jets in practical applications are found to be of large aspect ratio, the focus was shifted to studying synthetic jets of large aspect ratio. In the current year, further progress has been made by studying jets of aspect ratio 8 and infinity. Some other aspects of the jet, like the vorticity flux is looked into apart from analyzing the vortex dynamics, velocity profiles and the other dynamical characteristics of the jet which allows us to extract some insight into the effect of these modifications on the jet performance. Also, efforts were made to qualitatively validate the simulated results with the NASA Langley test cases at higher jet Reynolds number for the quiescent jet case.

Implications of Upwells as Hydrodynamic Jets in a Pulse Jet Mixed System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pease, Leonard F.; Bamberger, Judith A.; Minette, Michael J.

This report evaluates the physics of the upwell flow in pulse jet mixed systems in the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Although the initial downward flow and radial flow from jets characteristic of pulse jet mixers (PJMs) has been analyzed, the upwells have received considerably less attention despite having significant implications for vessel mixing. Do the upwells behave like jets? How do the upwells scale? When will the central upwell break through? What proportion of the vessel is blended by the upwells themselves? Indeed, how the physics of the central upwell is affected by multiple PJMs (e.g.,more » six in the proposed mixing vessels), non-Newtonian rheology, and significant multicomponent solids loadings remain unexplored.« less

An experimental study of multiple jet mixing

NASA Technical Reports Server (NTRS)

Krothapalli, D.; Baganoff, D.; Karamcheti, K.

1979-01-01

Measurements of an incompressible jet issuing from an array of rectangular lobes, equally spaced with their small dimensions in a line, both as a free jet, and as a confined jet, are carried out in three parts: (1) on a single rectangular free jet, (2) on the same jet in a multiple free jet configuration, and (3) on the same jet in a multiple jet configuration with confining surfaces (two parallel plates are symmetrically placed perpendicular to the long dimension of each lobe covering the entire flow field under consideration). In the case of a single rectangular free jet, the flow field of the jet is characterized by the presence of three distinct regions in the axial mean velocity decay and are referred to as: potential core region, two dimensional type region, and axisymmetric type region. In the case of a multiple free jet, the flow field for downstream distance X greater than 60D (D = width of a lobe) resembles that of a jet exiting from a two dimensional nozzle with its short dimension being the long dimension of the lobe.

Investigating critical effects of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose tablets.

PubMed

Patadia, Riddhish; Vora, Chintan; Mittal, Karan; Mashru, Rajashree

2016-01-01

The research envisaged focuses on vital impacts of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose (EC) tablets using prednisone as a model drug. Several lubricants and glidants such as magnesium stearate, colloidal SiO2, sodium stearyl fumarate, talc, stearic acid, polyethylene glycol (6000) and glyceryl behenate were investigated to understand their effects on lag time by changing their concentrations in outer coat. Further, the effects of hydrophilic additives on lag time were examined for hydroxypropylmethylcellulose (E5), hydroxypropylcellulose (EF and SSL), povidone (K30), copovidone, polyethylene glycol (4000), lactose and mannitol. In vitro drug release testing revealed that each selected lubricant/glidant, if present even at concentration of 0.25% w/w, significantly reduced the lag time of press coated tablets. Specifically, colloidal SiO2 and/or magnesium stearate were detrimental while other lubricants/glidants were relatively less injurious. Among hydrophilic additives, freely water soluble fillers had utmost influence in lag time, whereas, comparatively less impact was observed with polymeric binders. Concisely, glidant and lubricant should be chosen to have minimal impact on lag time and further judicious selection of hydrophilic additives should be exercised for modulating lag time of pulsatile release formulations.

Reducing the lag of accommodation by auditory biofeedback: A pilot study.

PubMed

Wagner, Sandra; Ohlendorf, Arne; Schaeffel, Frank; Wahl, Siegfried

2016-12-01

The purpose of this study was to investigate whether a reduction of the accommodative lag is possible by training the accuracy of accommodation using auditory biofeedback. Accommodation responses were measured in thirty-one young adults with myopia for dioptric target distances of 2.0, 2.5, and 3.0D using an eccentric infrared photorefractor. For the biofeedback training, subjects were randomly assigned to an experimental (n=15) or a control group (n=16). Subjects of the experimental group were provided with two tones while fixating a target, one tone was related to their accommodative response and the second to the target distance. Their task was to match these tones. The control group did not receive any auditory biofeedback. Two different training methods were applied, a continuous training of 200s, and ten consecutive sessions of 20s each. The training effects on the lag of accommodation (change Δ) were highly variable. Regarding the entire study group, the observed change in the accommodative lag was greater at closer distances, while no difference between the two training methods was revealed. Nevertheless, seven experimental subjects reduced their lag by ⩾0.3D (3.0D target distance: Δ long =-0.29±0.20D, Δ short =-0.24±0.21D). This reduction was also seen in two control subjects. Remeasurement revealed that the average training effect cannot be preserved over a period of 5-7days. The current investigation has shown that the accuracy of accommodation can be trained in some subjects using auditory biofeedback for target distances of 2.5D or closer. Copyright © 2016 Elsevier Ltd. All rights reserved.

Internet and free press are associated with reduced lags in global outbreak reporting.

PubMed

McAlarnen, Lindsey; Smith, Katherine; Brownstein, John S; Jerde, Christopher

2014-10-30

Global outbreak detection and reporting have generally improved for a variety of infectious diseases and geographic regions in recent decades. Nevertheless, lags in outbreak reporting remain a threat to the global human health and economy. In the time between first occurrence of a novel disease incident and public notification of an outbreak, infected individuals have a greater possibility of traveling and spreading the pathogen to other nations. Shortening outbreak reporting lags has the potential to improve global health by preventing local outbreaks from escalating into global epidemics. Reporting lags between the first record and the first public report of an event were calculated for 318 outbreaks occurring 1996-2009. The influence of freedom of the press, Internet usage, per capita health expenditure, and cell phone subscriptions, on the timeliness of outbreak reporting was evaluated. Freer presses and increasing Internet usage correlate with reduced time between the first record of an outbreak and the public report. Increasing Internet usage reduced the expected reporting lag from more than one month in nations without Internet users to one day in those where 75 of 100 people use the Internet. Advances in technology and the emergence of more open and free governments are associated with to improved global infectious disease surveillance.

A Fixed-Lag Kalman Smoother to Filter Power Line Interference in Electrocardiogram Recordings.

PubMed

Warmerdam, G J J; Vullings, R; Schmitt, L; Van Laar, J O E H; Bergmans, J W M

2017-08-01

Filtering power line interference (PLI) from electrocardiogram (ECG) recordings can lead to significant distortions of the ECG and mask clinically relevant features in ECG waveform morphology. The objective of this study is to filter PLI from ECG recordings with minimal distortion of the ECG waveform. In this paper, we propose a fixed-lag Kalman smoother with adaptive noise estimation. The performance of this Kalman smoother in filtering PLI is compared to that of a fixed-bandwidth notch filter and several adaptive PLI filters that have been proposed in the literature. To evaluate the performance, we corrupted clean neonatal ECG recordings with various simulated PLI. Furthermore, examples are shown of filtering real PLI from an adult and a fetal ECG recording. The fixed-lag Kalman smoother outperforms other PLI filters in terms of step response settling time (improvements that range from 0.1 to 1 s) and signal-to-noise ratio (improvements that range from 17 to 23 dB). Our fixed-lag Kalman smoother can be used for semi real-time applications with a limited delay of 0.4 s. The fixed-lag Kalman smoother presented in this study outperforms other methods for filtering PLI and leads to minimal distortion of the ECG waveform.

Effects over time of self-reported direct and vicarious racial discrimination on depressive symptoms and loneliness among Australian school students.

PubMed

Priest, Naomi; Perry, Ryan; Ferdinand, Angeline; Kelaher, Margaret; Paradies, Yin

2017-02-03

Racism and racial discrimination are increasingly acknowledged as a critical determinant of health and health inequalities. However, patterns and impacts of racial discrimination among children and adolescents remain under-investigated, including how different experiences of racial discrimination co-occur and influence health and development over time. This study examines associations between self-reported direct and vicarious racial discrimination experiences and loneliness and depressive symptoms over time among Australian school students. Across seven schools, 142 students (54.2% female), age at T1 from 8 to 15 years old (M = 11.14, SD = 2.2), and from diverse racial/ethnic and migration backgrounds (37.3% born in English-speaking countries as were one or both parents) self-reported racial discrimination experiences (direct and vicarious) and mental health (depressive symptoms and loneliness) at baseline and 9 months later at follow up. A full cross-lagged panel design was modelled using MPLUS v.7 with all variables included at both time points. A cross-lagged effect of perceived direct racial discrimination on later depressive symptoms and on later loneliness was found. As expected, the effect of direct discrimination on both health outcomes was unidirectional as mental health did not reciprocally influence reported racism. There was no evidence that vicarious racial discrimination influenced either depressive symptoms or loneliness beyond the effect of direct racial discrimination. Findings suggest direct racial discrimination has a persistent effect on depressive symptoms and loneliness among school students over time. Future work to explore associations between direct and vicarious discrimination is required.

Benchmark studies of thermal jet mixing in SFRs using a two-jet model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Omotowa, O. A.; Skifton, R.; Tokuhiro, A.

To guide the modeling, simulations and design of Sodium Fast Reactors (SFRs), we explore and compare the predictive capabilities of two numerical solvers COMSOL and OpenFOAM in the thermal jet mixing of two buoyant jets typical of the outlet flow from a SFR tube bundle. This process will help optimize on-going experimental efforts at obtaining high resolution data for V and V of CFD codes as anticipated in next generation nuclear systems. Using the k-{epsilon} turbulence models of both codes as reference, their ability to simulate the turbulence behavior in similar environments was first validated for single jet experimental datamore » reported in literature. This study investigates the thermal mixing of two parallel jets having a temperature difference (hot-to-cold) {Delta}T{sub hc}= 5 deg. C, 10 deg. C and velocity ratios U{sub c}/U{sub h} = 0.5, 1. Results of the computed turbulent quantities due to convective mixing and the variations in flow field along the axial position are presented. In addition, this study also evaluates the effect of spacing ratio between jets in predicting the flow field and jet behavior in near and far fields. (authors)« less

Lagged effects of family-supportive organization perceptions and supervision in relation to generalized work-related resources.

PubMed

Matthews, Russell A; Toumbeva, Tatiana H

2015-07-01

In the present study, grounded in organizational support and social exchange theory, the dynamic lagged interplay between family supportive supervision (FSS), family supportive organization perceptions (FSOP), perceived organizational support (POS), and leader-member exchange (LMX) was examined. Data were collected from 435 respondents over 3 time points with 6-week lags between assessments. Consistent with theory, FSS had a significant lagged effect on FSOP, whereas the reverse relationship was not supported. Interestingly, contrary to conservation of resources theory, we did not find significant lagged effects between POS and FSOP. Results further indicated that LMX and FSS were reciprocally related over time, suggesting the potential for a dynamic, mutually beneficial exchange relationship between subordinates and supervisors. Theoretical implications and considerations for research and practice are discussed. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

On the Nature of QPO Phase Lags in Black Hole Candidates

NASA Technical Reports Server (NTRS)

Shaposhnikov, Nikolai

2012-01-01

Observations of quasi-periodic oscillations (QPOs) in X-ray binaries hold a key to understanding many aspects of these enigmatic systems. Complex appearance of the Fourier phase lags related to QPOs is one of the most puzzling observational effects in accreting black holes. In this Letter we show that QPO properties, including phase lags, can be explained in a framework of a simple scenario, where the oscillating media provides a feedback on the emerging spectrum. We demonstrate that the QPO waveform is presented by the product of a perturbation and a time delayed response factors, where the response is energy dependent. The essential property of this effect is its non-linear and multiplicative nature. Our multiplicative reverberation model successfully describes the QPO components in energy dependent power spectra as well as the appearance of the phase lags between signal in different energy bands. We apply our model to QPOs observed by Rossi X-ray Timing Explorer in BH candidate XTE J1550-564. We briefly discuss the implications of the observed energy dependence of the QPO reverberation times and amplitudes to the nature of the power law spectral component and its variability.

Flow Channel Influence of a Collision-Based Piezoelectric Jetting Dispenser on Jet Performance

PubMed Central

Deng, Guiling; Li, Junhui; Duan, Ji’an

2018-01-01

To improve the jet performance of a bi-piezoelectric jet dispenser, mathematical and simulation models were established according to the operating principle. In order to improve the accuracy and reliability of the simulation calculation, a viscosity model of the fluid was fitted to a fifth-order function with shear rate based on rheological test data, and the needle displacement model was fitted to a nine-order function with time based on real-time displacement test data. The results show that jet performance is related to the diameter of the nozzle outlet and the cone angle of the nozzle, and the impacts of the flow channel structure were confirmed. The approach of numerical simulation is confirmed by the testing results of droplet volume. It will provide a reliable simulation platform for mechanical collision-based jet dispensing and a theoretical basis for micro jet valve design and improvement. PMID:29677140

Superfast Cosmic Jet "Hits the Wall"

NASA Astrophysics Data System (ADS)

1999-01-01

A superfast jet of subatomic particles presumably powered by the gravitational energy of a black hole has collided with nearby material, been slowed dramatically and released much of its energy in the collision, radio astronomers report. The astronomers used the National Science Foundation's Very Large Array (VLA) radio telescope to observe the jet's motion. This is the first time such a collision has been seen within our own Milky Way Galaxy, and the collision may shed new light on the physics of cosmic jets. Robert Hjellming, Michael Rupen and Frank Ghigo of the National Radio Astronomy Observatory (NRAO); Amy Mioduszewski of the Joint Institute for VLBI in Europe; Don Smith of MIT's Space Research Lab; Alan Harmon of Marshall Space Flight Center, and Elizabeth Waltman of the Naval Research Laboratory reported their findings today at the American Astronomical Society's meeting in Austin, TX. The cosmic jet comes from an object called XTE J1748-288, at least 30,000 light-years away in the constellation Sagittarius, near the center of the Milky Way. XTE J1748-288, discovered on June 4, 1998, by Don Smith, using the RXTE satellite, is a "black hole candidate," probably consisting of a black hole drawing material from a companion star and accelerating jets of material outward in the process. A series of VLA images showed a "blob" of material in the jet moving at an apparent speed at least 50 percent greater than that of light. This is only the third such "superluminal" jet seen in our own Galaxy. The apparent faster-than-light motion is an illusion created by geometric effects when jets move at nearly the speed of light and are aligned so that their motion is somewhat toward Earth. The two other Milky Way objects whose jets show such rapid motion are dubbed "microquasars," because their behavior mimics that of quasars -- much larger objects seen at the cores of very distant galaxies. A series of VLA images showed material ejected as a jet from the core of XTE J1748

Corkscrew Structures and Precessing Jets

NASA Astrophysics Data System (ADS)

Sahai, Raghvendra

2005-07-01

Collimated jets are one of the most intriguing, yet poorly understood phenomena in astrophysics. Jets have been found in a wide variety of object classes which include AGNs, YSOs, massive X-ray binaries {e.g. SS433}, black hole X-ray transients, symbiotic stars, supersoft X-ray sources, and finally, planetary and preplanetary nebulae {PNs & PPNs}. In the case of PNs and PPNs, we have propsoed that wobbling collimated jets are the universal mechanism which can shape the wide variety of bipolar and multipolar morphologies seen in these objects. Most of our knowledge of post-AGB jets is indirectly inferred from their effects on the circumstellar envelopes of the progenitor AGB stars and, for that reason, these jets remain very poorly understood. Thus the mechanism that powers and collimates these jet-like post-AGB outflows remains as one of the most important, unsolved issues in post-AGB evolution. We propose an archival study of two bipolar PPNs, motivated by two recent discoveries which indicate that precessing jets are likely to be operational in them, and that the properties of the jets and the bipolar lobes produced by them, may be directly measured. One of these is IRAS16342-3814 {IRAS1634}, previously imaged with WPFC2, in which new Adaptive Optics {AO} observations at near-IR wavelengths show a remarkable corkscrew-shaped structure, the tell-tale signature of a precessing jet. Inspection of WFPC2 images of another PPN, OH231.8+4.2 in which we have recently discovered a A-type companion to the central mass-losing star, shows a sinuous nebulosity in a broad-band continuum image, resembling a corkscrew structure. We will use the latter to constrain the phsyical properties of the jet {precession period, opening angle, jet beam diameter, temporal history} in OH231.8. Using the multi-wavelength data on both sources, we will build models of the density distribution of the lobes and their interiors. In the case of IRAS1634, these models will be used to investigate the

Development of an Empirical Methods for Predicting Jet Mixing Noise of Cold Flow Rectangular Jets

NASA Technical Reports Server (NTRS)

Russell, James W.

1999-01-01

This report presents an empirical method for predicting the jet mixing noise levels of cold flow rectangular jets. The report presents a detailed analysis of the methodology used in development of the prediction method. The empirical correlations used are based on narrow band acoustic data for cold flow rectangular model nozzle tests conducted in the NASA Langley Jet Noise Laboratory. There were 20 separate nozzle test operating conditions. For each operating condition 60 Hz bandwidth microphone measurements were made over a frequency range from 0 to 60,000 Hz. Measurements were performed at 16 polar directivity angles ranging from 45 degrees to 157.5 degrees. At each polar directivity angle, measurements were made at 9 azimuth directivity angles. The report shows the methods employed to remove screech tones and shock noise from the data in order to obtain the jet mixing noise component. The jet mixing noise was defined in terms of one third octave band spectral content, polar and azimuth directivity, and overall power level. Empirical correlations were performed over the range of test conditions to define each of these jet mixing noise parameters as a function of aspect ratio, jet velocity, and polar and azimuth directivity angles. The report presents the method for predicting the overall power level, the average polar directivity, the azimuth directivity and the location and shape of the spectra for jet mixing noise of cold flow rectangular jets.

Acoustics of Excited Jets: A Historical Perspective

NASA Technical Reports Server (NTRS)

Brown, Cliffard A.

2005-01-01

The idea that a jet may be excited by external forcing is not new. The first published demonstration of a jet responding to external pressure waves occurred in the mid-1800's. It was not, however, until the 1950's, with the advent of commercial jet aircraft, that interest in the subject greatly increased. Researchers first used excited jets to study the structure of the jet and attempt to determine the nature of the noise sources. The jet actuators of the time limited the range (Reynolds and Mach numbers) of jets that could be excited. As the actuators improved, more realistic jets could be studied. This has led to a better understanding of how jet excitation may be used not only as a research tool to understand the flow properties and noise generation process, but also as a method to control jet noise.

Spillover between Marital Quality and Parent-child Relationship Quality: Parental Depressive Symptoms as Moderators

PubMed Central

Kouros, Chrystyna D.; Papp, Lauren M.; Goeke-Morey, Marcie C.; Cummings, E. Mark

2015-01-01

Using a daily diary method, this study examined concurrent and time-lagged relations between marital and parent-child relationship qualities, providing a test of the spillover and compensatory hypotheses. Additionally, this study tested both mothers’ and fathers’ depressive symptoms as moderators of these daily linkages. Participants were 203 families, in which mothers and fathers completed daily diaries for 15 days. At the end of each reporting day, parents independently rated the emotional quality of their relationship with their spouse and with their child that day. Controlling for global levels of marital satisfaction, marital conflict, and parenting, a positive association was found between mothers’ and fathers’ daily ratings of marital quality and their ratings of parent-child relationship quality, supporting the spillover hypothesis. When considering time-lagged relations, support was found for the compensatory hypothesis for mothers: lower levels of marital quality were related to increases in mother-child relationship quality from one day to the next. Further, both maternal and paternal depressive symptoms moderated the link between marital quality and the other parent’s relationship quality with their child. Whereas maternal depressive symptoms strengthened spillover relations for fathers on the next day, paternal depression was related to less spillover for mothers on the same day. Alternative models did not find evidence for parent-child relationship quality as a predictor of changes in marital quality on the next day. The findings underscore the importance of the quality of the marital relationship for predicting the quality of other family relationships. PMID:24821519

Implications of Upwells as Hydrodynamic Jets in a Pulse Jet Mixed System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pease, Leonard F.; Bamberger, Judith A.; Minette, Michael J.

2015-08-01

This report evaluates the physics of the upwell flow in pulse jet mixed systems in the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Although the initial downward flow and radial flow from pulse jet mixers (PJMs) has been analyzed in some detail, the upwells have received considerably less attention despite having significant implications for vessel mixing. Do the upwells behave like jets? How do the upwells scale? When will the central upwell breakthrough? What proportion of the vessel is blended by the upwells themselves? Indeed, how the physics of the central upwell is affected by multiple PJMs (e.g., sixmore » in the proposed mixing vessels), non-Newtonian rheology, and significant multicomponent solids loadings remain unexplored. The central upwell must satisfy several criteria to be considered a free jet. First, it must travel for several diameters in a nearly constant direction. Second, its velocity must decay with the inverse of elevation. Third, it should have an approximately Gaussian profile. Fourth, the influence of surface or body forces must be negligible. A combination of historical data in a 12.75 ft test vessel, newly analyzed data from the 8 ft test vessel, and conservation of momentum arguments derived specifically for PJM operating conditions demonstrate that the central upwell satisfies these criteria where vigorous breakthrough is achieved. An essential feature of scaling from one vessel to the next is the requirement that the underlying physics does not change adversely. One may have confidence in scaling if (1) correlations and formulas capture the relevant physics; (2) the underlying physics does not change from the conditions under which it was developed to the conditions of interest; (3) all factors relevant to scaling have been incorporated, including flow, material, and geometric considerations; and (4) the uncertainty in the relationships is sufficiently narrow to meet required specifications. Although the central

Consequences of Fluid Lag in Three-Dimensional Hydraulic Fractures

NASA Astrophysics Data System (ADS)

Advani (Deceased), S. H.; Lee, T. S.; Dean, R. H.; Pak, C. K.; Avasthi, J. M.

1997-04-01

Research investigations on three-dimensional (3-D) rectangular hydraulic fracture configurations with varying degrees of fluid lag are reported. This paper demonstrates that a 3-D fracture model coupled with fluid lag (a small region of reduced pressure) at the fracture tip can predict very large excess pressure measurements for hydraulic fracture processes. Predictions of fracture propagation based on critical stress intensity factors are extremely sensitive to the pressure profile at the tip of a propagating fracture. This strong sensitivity to the pressure profile at the tip of a hydraulic fracture is more strongly pronounced in 3-D models versus 2-D models because 3-D fractures are clamped at the top and bottom, and pressures in the 3-D fractures that are far removed from the fracture tip have little effect on the stress intensity factor at the fracture tip. This rationale for the excess pressure mechanism is in marked contrast to the crack tip process damage zone assumptions and attendant high rock fracture toughness value hypotheses advanced in the literature. A comparison with field data is presented to illustrate the proposed fracture fluid pressure sensitivity phenomenon. This paper does not attempt to calculate the length of the fluid lag region in a propagating fracture but instead attempts to show that the pressure profile at the tip of the propagating fracture plays a major role in fracture propagation, and this role is magnified in 3-D models. Int. J. Numer. Anal. Meth. Geomech., vol. 21, 229-240 (1997).

State-dependent resource harvesting with lagged information about system states

USGS Publications Warehouse

Johnson, Fred A.; Fackler, Paul L.; Boomer, G Scott; Zimmerman, Guthrie S.; Williams, Byron K.; Nichols, James D.; Dorazio, Robert

2016-01-01

Markov decision processes (MDPs), which involve a temporal sequence of actions conditioned on the state of the managed system, are increasingly being applied in natural resource management. This study focuses on the modification of a traditional MDP to account for those cases in which an action must be chosen after a significant time lag in observing system state, but just prior to a new observation. In order to calculate an optimal decision policy under these conditions, possible actions must be conditioned on the previous observed system state and action taken. We show how to solve these problems when the state transition structure is known and when it is uncertain. Our focus is on the latter case, and we show how actions must be conditioned not only on the previous system state and action, but on the probabilities associated with alternative models of system dynamics. To demonstrate this framework, we calculated and simulated optimal, adaptive policies for MDPs with lagged states for the problem of deciding annual harvest regulations for mallards (Anas platyrhynchos) in the United States. In this particular example, changes in harvest policy induced by the use of lagged information about system state were sufficient to maintain expected management performance (e.g. population size, harvest) even in the face of an uncertain system state at the time of a decision.

Extending the Distributed Lag Model framework to handle chemical mixtures.

PubMed

Bello, Ghalib A; Arora, Manish; Austin, Christine; Horton, Megan K; Wright, Robert O; Gennings, Chris

2017-07-01

Distributed Lag Models (DLMs) are used in environmental health studies to analyze the time-delayed effect of an exposure on an outcome of interest. Given the increasing need for analytical tools for evaluation of the effects of exposure to multi-pollutant mixtures, this study attempts to extend the classical DLM framework to accommodate and evaluate multiple longitudinally observed exposures. We introduce 2 techniques for quantifying the time-varying mixture effect of multiple exposures on an outcome of interest. Lagged WQS, the first technique, is based on Weighted Quantile Sum (WQS) regression, a penalized regression method that estimates mixture effects using a weighted index. We also introduce Tree-based DLMs, a nonparametric alternative for assessment of lagged mixture effects. This technique is based on the Random Forest (RF) algorithm, a nonparametric, tree-based estimation technique that has shown excellent performance in a wide variety of domains. In a simulation study, we tested the feasibility of these techniques and evaluated their performance in comparison to standard methodology. Both methods exhibited relatively robust performance, accurately capturing pre-defined non-linear functional relationships in different simulation settings. Further, we applied these techniques to data on perinatal exposure to environmental metal toxicants, with the goal of evaluating the effects of exposure on neurodevelopment. Our methods identified critical neurodevelopmental windows showing significant sensitivity to metal mixtures. Copyright © 2017 Elsevier Inc. All rights reserved.

Experimental and Theoretical Studies of Axisymmetric Free Jets

NASA Technical Reports Server (NTRS)

Love, Eugene S.; Grigsby, Carl E.; Lee, Louise P.; Woodling, Mildred J.

1959-01-01

Some experimental and theoretical studies have been made of axisymmetric free jets exhausting from sonic and supersonic nozzles into still air and into supersonic streams with a view toward problems associated with propulsive jets and the investigation of these problems. For jets exhausting into still air, consideration is given to the effects of jet Mach number, nozzle divergence angle, and jet static pressure ratio upon jet structure, jet wavelength, and the shape and curvature of the jet boundary. Studies of the effects of the ratio of specific heats of the jets are included are observations pertaining to jet noise and jet simulation. For jets exhausting into supersonic streams, an attempt has been made to present primarily theoretical certain jet interference effects and in formulating experimental studies. The primary variables considered are jet Mach number, free stream Mach number, jet static pressure ratio, ratio of specific heats of the jet, nozzle exit angle, and boattail angle. The simulation problem and the case of a hypothetical hypersonic vehicle are examined, A few experimental observations are included.

Four-Year Cross-Lagged Associations between Physical and Mental Health in the Medical Outcomes Study.

ERIC Educational Resources Information Center

Hays, Ron D.; And Others

1994-01-01

Applied structural equation modeling to evaluation of cross-lagged panel models. Self-reports of physical and mental health at three time points spanning four-year interval were analyzed to illustrate cross-lagged analysis methodology. Data were analyzed from 856 patients with hypertension, diabetes, heart disease, or depression. Cross-lagged…

Modeling the lag period and exponential growth of Listeria monocytogenes under conditions of fluctuating temperature and water activity values.

PubMed

Muñoz-Cuevas, Marina; Fernández, Pablo S; George, Susan; Pin, Carmen

2010-05-01

The dynamic model for the growth of a bacterial population described by Baranyi and Roberts (J. Baranyi and T. A. Roberts, Int. J. Food Microbiol. 23:277-294, 1994) was applied to model the lag period and exponential growth of Listeria monocytogenes under conditions of fluctuating temperature and water activity (a(w)) values. To model the duration of the lag phase, the dependence of the parameter h(0), which quantifies the amount of work done during the lag period, on the previous and current environmental conditions was determined experimentally. This parameter depended not only on the magnitude of the change between the previous and current environmental conditions but also on the current growth conditions. In an exponentially growing population, any change in the environment requiring a certain amount of work to adapt to the new conditions initiated a lag period that lasted until that work was finished. Observations for several scenarios in which exponential growth was halted by a sudden change in the temperature and/or a(w) were in good agreement with predictions. When a population already in a lag period was subjected to environmental fluctuations, the system was reset with a new lag phase. The work to be done during the new lag phase was estimated to be the workload due to the environmental change plus the unfinished workload from the uncompleted previous lag phase.

The Bidirectional Relationship Between Depressive Symptoms and Homebound Status Among Older Adults.

PubMed

Xiang, Xiaoling; An, Ruopeng; Oh, Hyunsung